RLID Gene_ID Gene_Name Link Aliases RNA_category Organism PMID Subcellular_Localization tissue Methods Description RLID00000001 100003563 stmn2b http://www.ncbi.nlm.nih.gov/gene/?term=100003563 "scg10, scgn10, stmn2, zgc:110132 " mRNA Danio rerio 24089481 Axon Embryoneuron Whole mount in situ hybridization "Here, we provide direct evidence of the presence of mRNAs of the tubb5, nefma, and stmnb2 genes in several types of axons in the developing zebrafish (Danio rerio) embryo, with frequent accumulation at the growth cone. We further show that axonal localization of mRNA is a specific property of a subset of genes, as mRNAs of the huc and neurod genes, abundantly expressed in neurons, were not found in axons. " RLID00000002 100008586 GAGE12F http://www.ncbi.nlm.nih.gov/gene/?term=100008586 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000003 100008588 RNA18S5 http://www.ncbi.nlm.nih.gov/gene/?term=100008588 RN18S1 rRNA Homo sapiens 25753659 Cytoplasm HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00000004 100008588 RNA18S5 http://www.ncbi.nlm.nih.gov/gene/?term=100008588 RN18S1 rRNA Homo sapiens 25753659 Ribosome HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00000005 100008589 RNA28S5 http://www.ncbi.nlm.nih.gov/gene/?term=100008589 RN28S1 rRNA Homo sapiens 25753659 Ribosome HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00000006 100008589 RNA28S5 http://www.ncbi.nlm.nih.gov/gene/?term=100008589 RN28S1 rRNA Homo sapiens 16178658 Endoplasmic reticulum HDF cell Fluorescence in situ hybridization "Extensive control studies are performed, including the use of fluorescence in-situ hybridization (FISH), negative-control beacons, and the detection of colocalization of 28S ribosomal RNA with the rough endoplasmic reticulum (ER), suggesting that the mRNA localization and colocalization patterns observed in our study are true and specific. " RLID00000007 100008589 RNA28S5 http://www.ncbi.nlm.nih.gov/gene/?term=100008589 RN28S1 rRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000008 100008589 RNA28S5 http://www.ncbi.nlm.nih.gov/gene/?term=100008589 RN28S1 rRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000009 100008589 RNA28S5 http://www.ncbi.nlm.nih.gov/gene/?term=100008589 RN28S1 rRNA Homo sapiens 25753659 Cytoplasm HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00000010 100009667 POU5F1P5 http://www.ncbi.nlm.nih.gov/gene/?term=100009667 Oct4-pg5 lncRNA Homo sapiens 21151833 Nucleus Breast cancer cell qRT-PCR We next analyzed nuclear run-on samples using primers specific for Oct4 transcript variant 2 and Oct4 pseudogene 4 and we observed a significant increase in transcription of both these RNA species (Fig. 3B and C). Data are collected from Figure 3. RLID00000011 10000 AKT3 http://www.ncbi.nlm.nih.gov/gene/?term=10000 "MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000012 10000 AKT3 http://www.ncbi.nlm.nih.gov/gene/?term=10000 "MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000013 100019 Mdn1 http://www.ncbi.nlm.nih.gov/gene/?term=100019 "4833432B22Rik, A130070M06, AA958993, D4Abb1e, Gm135 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000014 10001 MED6 http://www.ncbi.nlm.nih.gov/gene/?term=10001 "ARC33, NY-REN-28 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000015 100034733 2610305J24Rik http://www.ncbi.nlm.nih.gov/gene/?term=100034733 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000016 100034739 Gm17762 http://www.ncbi.nlm.nih.gov/gene/?term=100034739 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000017 100036887 ppp1r2 http://www.ncbi.nlm.nih.gov/gene/?term=100036887 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00000018 100037236 grip2 http://www.ncbi.nlm.nih.gov/gene/?term=100037236 "grip2.1, xgrip2 " mRNA Xenopus laevis 17320814 Germ plasm Embryo In situ hybridization "Using a large-scale in situ hybridization screening, we found that the mRNA coding for Xenopus glutamate receptor interacting protein 2 (XGRIP2) was localized to the germ plasm of Xenopus laevis. " RLID00000019 100037236 grip2 http://www.ncbi.nlm.nih.gov/gene/?term=100037236 "grip2.1, xgrip2 " mRNA Xenopus laevis 17924960 Mitochondrion Oocyte In situ hybridization Grip2 mRNA is present in the mitochondrial cloud of late pre-vitellogenic oocytes and then in the germ plasm through oogenesis and early development until tailbud tadpole stages. RLID00000020 100037236 grip2 http://www.ncbi.nlm.nih.gov/gene/?term=100037236 "grip2.1, xgrip2 " mRNA Xenopus laevis 17924960 Germ plasm Oocyte In situ hybridization Grip2 mRNA is present in the mitochondrial cloud of late pre-vitellogenic oocytes and then in the germ plasm through oogenesis and early development until tailbud tadpole stages. RLID00000021 100037236 grip2 http://www.ncbi.nlm.nih.gov/gene/?term=100037236 "grip2.1, xgrip2 " mRNA Xenopus laevis 21788733 Mitochondrion Oocyte RNA localization assays "Here, we demonstrate that the 3'-UTR of XGrip2.1 contains a 211 nucleotide RNA signal sequence that promotes localization to the mitochondrial cloud via the early localization pathway upon injection into stage I oocytes. " RLID00000022 100037236 grip2 http://www.ncbi.nlm.nih.gov/gene/?term=100037236 "grip2.1, xgrip2 " mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00000023 100037417 DDTL http://www.ncbi.nlm.nih.gov/gene/?term=100037417 KB-226F1.2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000024 100038259 sulf1 http://www.ncbi.nlm.nih.gov/gene/?term=100038259 "XtSulf-1, XtSulf1, hsulf-1, sulf-1 " mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00000025 100038470 Gm10808 http://www.ncbi.nlm.nih.gov/gene/?term=100038470 ENSMUSG00000075047 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000026 100038555 Gm10578 http://www.ncbi.nlm.nih.gov/gene/?term=100038555 ENSMUSG00000073800 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000027 100038570 Gm11744 http://www.ncbi.nlm.nih.gov/gene/?term=100038570 "OTTMUSG00000003947, Prcd " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000028 100038589 Gm10744 http://www.ncbi.nlm.nih.gov/gene/?term=100038589 ENSMUSG00000074683 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000029 100038630 Gm10727 http://www.ncbi.nlm.nih.gov/gene/?term=100038630 ENSMUSG00000074599 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000030 100038644 Gm10667 http://www.ncbi.nlm.nih.gov/gene/?term=100038644 ENSMUSG00000074318 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000031 100038687 Gm10577 http://www.ncbi.nlm.nih.gov/gene/?term=100038687 ENSMUSG00000073789 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000032 100038723 Sox5it http://www.ncbi.nlm.nih.gov/gene/?term=100038723 "ENSMUSG00000072677, Gm10396 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000033 100039795 Ildr2 http://www.ncbi.nlm.nih.gov/gene/?term=100039795 "2810478N18Rik, 3110063L10Rik, AI852300, D1Ertd471e, Dbsm1, ENSMUSG00000040612, Ll " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000034 100040322 3830408C21Rik http://www.ncbi.nlm.nih.gov/gene/?term=100040322 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000035 100040529 Gm2824 http://www.ncbi.nlm.nih.gov/gene/?term=100040529 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000036 100040736 Foxd2os http://www.ncbi.nlm.nih.gov/gene/?term=100040736 9130206I24Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000037 100040972 Tceal7 http://www.ncbi.nlm.nih.gov/gene/?term=100040972 1110018P05Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000038 100041143 Gm3161 http://www.ncbi.nlm.nih.gov/gene/?term=100041143 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000039 100041286 Snhg15 http://www.ncbi.nlm.nih.gov/gene/?term=100041286 "Gm11974, OTTMUSG00000005115 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000040 100041734 4930522L14Rik http://www.ncbi.nlm.nih.gov/gene/?term=100041734 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000041 100041806 LOC100041806 http://www.ncbi.nlm.nih.gov/gene/?term=100041806 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000042 100041932 Gm3579 http://www.ncbi.nlm.nih.gov/gene/?term=100041932 H3097D08 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000043 100042056 9130019P16Rik http://www.ncbi.nlm.nih.gov/gene/?term=100042056 "6430501H15Rik, OTTMUSG00000023151 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000044 100042166 Gm3704 http://www.ncbi.nlm.nih.gov/gene/?term=100042166 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000045 100042192 Gm3715 http://www.ncbi.nlm.nih.gov/gene/?term=100042192 5033421C21Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000046 100042198 Gm3716 http://www.ncbi.nlm.nih.gov/gene/?term=100042198 Gm1683 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000047 100042480 Nhsl2 http://www.ncbi.nlm.nih.gov/gene/?term=100042480 "1110062M06Rik, 6430511F03, AI225852, AW488865, EG621083, ENSMUSG00000073037, Gm10456 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000048 100042770 Gm4022 http://www.ncbi.nlm.nih.gov/gene/?term=100042770 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000049 100043034 Rex2 http://www.ncbi.nlm.nih.gov/gene/?term=100043034 "Gm13138, OTTMUSG00000010655 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000050 100043040 1110002L01Rik http://www.ncbi.nlm.nih.gov/gene/?term=100043040 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000051 100043089 Gm4221 http://www.ncbi.nlm.nih.gov/gene/?term=100043089 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000052 100043600 Gm4544 http://www.ncbi.nlm.nih.gov/gene/?term=100043600 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000053 100043636 AI662270 http://www.ncbi.nlm.nih.gov/gene/?term=100043636 AW496474 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000054 100043902 Six3os1 http://www.ncbi.nlm.nih.gov/gene/?term=100043902 "D17Mgi26, E130112H22Rik, Rncr1, Six3os " lncRNA Mus musculus 15703187 Nucleus Embryonic tissue In situ hybridization|RT-PCR "We detected the expression in adult retina (postnatal day 30, P30) of Six3OS, Six6OS, Otx2OS, CrxOS and RaxOS (Fig. 3 and data not shown). In general, these transcripts were all expressed at higher levels in the inner nuclear layer (INL) and in the ganglion cell layer (GCL). " RLID00000055 100043911 Ppp4r1l-ps http://www.ncbi.nlm.nih.gov/gene/?term=100043911 "1700007P14Rik, 5830403E09Rik, C030010B13Rik, Ppp4r1l " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000056 100048912 CDKN2B-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100048912 "ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS " lncRNA Homo sapiens 25690653 Nucleus P493-6 cell qRT-PCR "To validate the isolation of nuclear and cytoplasmic fractions, the enrichment of 3 nuclear (ANRIL, MIAT, XIST) and 3 cytoplasmic (RPPH1, DANCR, tRNA-Lys) RNAs was analyzed by qRT-PCR. " RLID00000057 100048912 CDKN2B-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100048912 "ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS " lncRNA Homo sapiens 25630241 Nucleus Hela cell qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00000058 100049226 ddx4 http://www.ncbi.nlm.nih.gov/gene/?term=100049226 "glh-1, olvas " mRNA Oryzias latipes 24814190 Germ plasm Germ cell Light|Microscopy Germ cells of diverse animal species have a unique membrane-less organelle called germ plasm (GP). GP is usually associated with mitochondria and contains RNA binding proteins and mRNAs of germ genes such as vasa. RLID00000059 100049418 dazl http://www.ncbi.nlm.nih.gov/gene/?term=100049418 mRNA Oryzias latipes 23439406 Mitochondrion Oocyte In situ hybridization "Here we report in the fish medaka (Oryzias latipes) that RNAs encoding microphthalmia-associated transcription factor (Mitf) are prominent components of the BB. By fluorescence in situ hybridization on ovarian section, we revealed that the transcripts of both mitf1 and mitf2 genes concentrated in the BB, in which they co-localized with the dazl RNA, a definitive BB marker highly conserved in vertebrates. " RLID00000060 100049571 Ancr-1 http://www.ncbi.nlm.nih.gov/gene/?term=100049571 lncRNA Apis mellifera 15208441 Nucleus Brain neurons In situ hybridization "In the present study, we identified another novel gene, termed AncR-1, whose transcripts were localized to nuclei in the whole cortex region of the honeybee brain, as a candidate novel noncoding nuclear RNA gene. " RLID00000061 100049572 Ks-1 http://www.ncbi.nlm.nih.gov/gene/?term=100049572 lncRNA Apis mellifera 12088150 Nucleus Kenyon cell In situ hybridization "Furthermore, fluorescent in situ hybridization revealed that Ks-1 transcripts are located in the nuclei of the neural cells, accumulating in some scattered spots. These findings demonstrate that Ks-1 encodes a novel class of noncoding nuclear RNA and is possibly involved in the regulation of neural functions. " RLID00000062 100049613 TRK-TTT3-4 http://www.ncbi.nlm.nih.gov/gene/?term=100049613 "TRK-TTT3-3, TRNAK3 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000063 10005 ACOT8 http://www.ncbi.nlm.nih.gov/gene/?term=10005 "HNAACTE, NAP1, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000064 10005 ACOT8 http://www.ncbi.nlm.nih.gov/gene/?term=10005 "HNAACTE, NAP1, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000065 100061 Lrrc19 http://www.ncbi.nlm.nih.gov/gene/?term=100061 "9130022A01Rik, AI314124, AL022954, AW261791 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000066 100061 Lrrc19 http://www.ncbi.nlm.nih.gov/gene/?term=100061 "9130022A01Rik, AI314124, AL022954, AW261791 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000067 10006 ABI1 http://www.ncbi.nlm.nih.gov/gene/?term=10006 "ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000068 10006 ABI1 http://www.ncbi.nlm.nih.gov/gene/?term=10006 "ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000069 10007 GNPDA1 http://www.ncbi.nlm.nih.gov/gene/?term=10007 "GNP1, GNPDA, GNPI, GPI, HLN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000070 10007 GNPDA1 http://www.ncbi.nlm.nih.gov/gene/?term=10007 "GNP1, GNPDA, GNPI, GPI, HLN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000071 10007 GNPDA1 http://www.ncbi.nlm.nih.gov/gene/?term=10007 "GNP1, GNPDA, GNPI, GPI, HLN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000072 10007 GNPDA1 http://www.ncbi.nlm.nih.gov/gene/?term=10007 "GNP1, GNPDA, GNPI, GPI, HLN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000073 100093630 SNHG8 http://www.ncbi.nlm.nih.gov/gene/?term=100093630 "LINC00060, NCRNA00060 " lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000074 100101685 cnksr2 http://www.ncbi.nlm.nih.gov/gene/?term=100101685 "cnk2, ksr2 " mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00000075 10010 TANK http://www.ncbi.nlm.nih.gov/gene/?term=10010 "I-TRAF, ITRAF, TRAF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000076 10010 TANK http://www.ncbi.nlm.nih.gov/gene/?term=10010 "I-TRAF, ITRAF, TRAF2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000077 10010 TANK http://www.ncbi.nlm.nih.gov/gene/?term=10010 "I-TRAF, ITRAF, TRAF2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000078 100113378 SNORD119 http://www.ncbi.nlm.nih.gov/gene/?term=100113378 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00000079 100113378 SNORD119 http://www.ncbi.nlm.nih.gov/gene/?term=100113378 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000080 100113378 SNORD119 http://www.ncbi.nlm.nih.gov/gene/?term=100113378 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000081 100113379 SNORD121A http://www.ncbi.nlm.nih.gov/gene/?term=100113379 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000082 100113380 SNORD125 http://www.ncbi.nlm.nih.gov/gene/?term=100113380 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000083 100113382 SNORD105B http://www.ncbi.nlm.nih.gov/gene/?term=100113382 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000084 100113382 SNORD105B http://www.ncbi.nlm.nih.gov/gene/?term=100113382 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00000085 100113382 SNORD105B http://www.ncbi.nlm.nih.gov/gene/?term=100113382 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00000086 100113386 UCKL1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100113386 "UCKL1-AS, UCKL1AS, UCKL1OS " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000087 100113391 SNORD126 http://www.ncbi.nlm.nih.gov/gene/?term=100113391 "MIR1201, MIRN1201 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000088 100113392 SNORD11B http://www.ncbi.nlm.nih.gov/gene/?term=100113392 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000089 100113393 SNORD12B http://www.ncbi.nlm.nih.gov/gene/?term=100113393 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000090 100113402 SNORD111B http://www.ncbi.nlm.nih.gov/gene/?term=100113402 MIR3647 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000091 100113407 TMEM170B http://www.ncbi.nlm.nih.gov/gene/?term=100113407 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000092 100113407 TMEM170B http://www.ncbi.nlm.nih.gov/gene/?term=100113407 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000093 10011 SRA1 http://www.ncbi.nlm.nih.gov/gene/?term=10011 "SRA, SRAP, STRAA1, pp7684 " lncRNA Homo sapiens 17170069 Cytoplasm S91|3T3|MCF-7|LNCaP cell In situ hybridization|RT-PCR "As shown in Fig. 5B, hSRA was cytoplasmic in the majority of cells (90%), but in the remainder it was localized in the nucleus in a distinctly speckled pattern, suggesting that hSRA is organized in yet another nuclear subcompartment. " RLID00000094 10011 SRA1 http://www.ncbi.nlm.nih.gov/gene/?term=10011 "SRA, SRAP, STRAA1, pp7684 " lncRNA Homo sapiens 17170069 Nucleus S91|3T3|MCF-7|LNCaP cell In situ hybridization|RT-PCR "As shown in Fig. 5B, hSRA was cytoplasmic in the majority of cells (?90%), but in the remainder it was localized in the nucleus in a distinctly speckled pattern, suggesting that hSRA is organized in yet another nuclear subcompartment. " RLID00000095 10011 SRA1 http://www.ncbi.nlm.nih.gov/gene/?term=10011 "SRA, SRAP, STRAA1, pp7684 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000096 100121 Tdrd7 http://www.ncbi.nlm.nih.gov/gene/?term=100121 "5730495N10Rik, AI447470, PCTAIRE2BP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000097 100124412 FAM138E http://www.ncbi.nlm.nih.gov/gene/?term=100124412 F379 lncRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00000098 100124516 SNORD58C http://www.ncbi.nlm.nih.gov/gene/?term=100124516 U58 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00000099 100124516 SNORD58C http://www.ncbi.nlm.nih.gov/gene/?term=100124516 U58 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000100 100124516 SNORD58C http://www.ncbi.nlm.nih.gov/gene/?term=100124516 U58 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000101 100124534 SNORA84 http://www.ncbi.nlm.nih.gov/gene/?term=100124534 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000102 100124536 SNORA38B http://www.ncbi.nlm.nih.gov/gene/?term=100124536 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000103 100124539 SNORA11B http://www.ncbi.nlm.nih.gov/gene/?term=100124539 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000104 100124700 HOTAIR http://www.ncbi.nlm.nih.gov/gene/?term=100124700 "HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 " lncRNA Homo sapiens 21963238 Nucleus Breast cancer cell qRT-PCR|Chip-seq "HOTAIR binding sites occur on multiple chromosomes and are enriched in genic regions, notably regions annotated as enhancers and introns (Fig. 5A). " RLID00000105 100124700 HOTAIR http://www.ncbi.nlm.nih.gov/gene/?term=100124700 "HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 " lncRNA Homo sapiens 22193719 Nucleus Embryonic stem cell qRT-PCR|Microarray "Figure 7: Neuronal lncRNAs act via diverse mechanisms. (A) Quantification of relative expression of lncRNAs in nuclear and cytoplasmic cell fractions. (B) Quantification of changes in hosted miRNAs in response to lncRNA_N2 knockdown. MiRNAs were quantified using Taqman miRNA qPCR. (C-E) RIP of lncRNAs with SUZ12 and REST antibodies. The interaction of HOTAIR with SUZ12 is a known interaction that serves as a positive control (Gupta et al, 2010). * and ** indicate P-values of <0.05 and <0.01, respectively. Data are collected from Figure 7. " RLID00000106 100124700 HOTAIR http://www.ncbi.nlm.nih.gov/gene/?term=100124700 "HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 " lncRNA Homo sapiens 23133536 Nucleus Breast cancer cell In situ hybridization "Of note, single molecule RNA FISH against HOTAIR in primary lung and foot fibroblast cells showed both nuclear and cytoplasmic localization [16], and recent chromatin immunoprecipitation experiments have localized HOTAIR in conjunction with PRC2 complex on chromatin in cancer cells " RLID00000107 100124700 HOTAIR http://www.ncbi.nlm.nih.gov/gene/?term=100124700 "HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 " lncRNA Homo sapiens 23133536 Cytoplasm Breast cancer cell In situ hybridization "Of note, single molecule RNA FISH against HOTAIR in primary lung and foot fibroblast cells showed both nuclear and cytoplasmic localization [16], and recent chromatin immunoprecipitation experiments have localized HOTAIR in conjunction with PRC2 complex on chromatin in cancer cells " RLID00000108 100124700 HOTAIR http://www.ncbi.nlm.nih.gov/gene/?term=100124700 "HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 " lncRNA Homo sapiens 19571010 Nucleus HFF|HLF|HeLa cell Fluorescence in situ hybridization "Figure 3b: Subcellular localization analysis of lincRNAs by RNA FISH demonstrates localization of lincRNAs to the nucleus. Each panel represents the in situ hybridization of �0 fluorescently labeled DNA oligos with complementarity to the interrogated lincRNA. RNA FISH experiments were performed in male hFF for each represented lincRNA (XIST, HOTAIR, TUG-1, lincMKLN-1, lincFOXF1, and lincSFPQ), and also in female hLF for XIST (XX). White “speckles�indicate the subcellular localization of each lincRNA. The nuclear compartment is demarked by DAPI staining (purple). " RLID00000109 100125288 ZGLP1 http://www.ncbi.nlm.nih.gov/gene/?term=100125288 "GATAD3, GLP-1, GLP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000110 100126243 A030001D20Rik http://www.ncbi.nlm.nih.gov/gene/?term=100126243 1110025D03Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000111 100126364 Floury1 http://www.ncbi.nlm.nih.gov/gene/100126364 GRMZM2G094532 mRNA Zea mays 11910012 Endoplasmic reticulum Endosperm In situ hybridization "We analyzed the distribution of mRNAs encoding the 22-kD alpha-zein and the 27-kD gamma-zein proteins on cisternal and protein body rough endoplasmic reticulum membranes. In situ hybridization revealed similar frequencies of the mRNAs in both regions of the endoplasmic reticulum, indicating that the transcripts are distributed more or less randomly. " RLID00000112 100126476 TRNAL-CAA http://www.ncbi.nlm.nih.gov/gene/?term=100126476 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000113 100126798 SNAR-A1 http://www.ncbi.nlm.nih.gov/gene/?term=100126798 SNAR-A53113498 lncRNA Homo sapiens 20935053 Cytoplasm HeLa cell qRT-PCR "To approach their function, we examined the subcellular distribution of snaR-A. Fractionation of 293, 293T and HeLa cells revealed snaR-A to be predominantly cytoplasmic (Figure 6A, upper panel). " RLID00000114 100126798 SNAR-A1 http://www.ncbi.nlm.nih.gov/gene/?term=100126798 SNAR-A53113498 lncRNA Homo sapiens 20935053 Ribosome HeLa cell qRT-PCR "SnaR-A is up-regulated in transformed and immortalized human cells, and is stably bound to ribosomes in HeLa cells. " RLID00000115 100127243 ddx59 http://www.ncbi.nlm.nih.gov/gene/?term=100127243 centroid mRNA Xenopus laevis 17939116 Mitochondrion Oocyte In situ hybridization "We found that centroid mRNA is localized in Xenopus oocytes by a combination of early and late pathways, a pattern of localization that is very similar to the intermediate pathway localization of fatvg mRNA, another germ-plasm-localized RNA in Xenopus oocytes. Also, centroid mRNA is present in the mitochondrial cloud and in the germ plasm at the surface of germinal granules. " RLID00000116 100127243 ddx59 http://www.ncbi.nlm.nih.gov/gene/?term=100127243 centroid mRNA Xenopus laevis 17939116 Germ plasm Oocyte In situ hybridization "We found that centroid mRNA is localized in Xenopus oocytes by a combination of early and late pathways, a pattern of localization that is very similar to the intermediate pathway localization of fatvg mRNA, another germ-plasm-localized RNA in Xenopus oocytes. Also, centroid mRNA is present in the mitochondrial cloud and in the germ plasm at the surface of germinal granules. " RLID00000117 100128108 LOC100128108 http://www.ncbi.nlm.nih.gov/gene/?term=100128108 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000118 100128385 FAM225B http://www.ncbi.nlm.nih.gov/gene/?term=100128385 "C9orf110, LINC00256B, NCRNA00256B " lncRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000119 100128731 OST4 http://www.ncbi.nlm.nih.gov/gene/?term=100128731 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000120 100128731 OST4 http://www.ncbi.nlm.nih.gov/gene/?term=100128731 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000121 100128881 VPS9D1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100128881 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000122 100129196 MATN1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100129196 lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000123 100129482 ZNF37BP http://www.ncbi.nlm.nih.gov/gene/?term=100129482 "KOX21, ZNF37B " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000124 100129550 LOC100129550 http://www.ncbi.nlm.nih.gov/gene/?term=100129550 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000125 100129550 LOC100129550 http://www.ncbi.nlm.nih.gov/gene/?term=100129550 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000126 100130581 LINC00910 http://www.ncbi.nlm.nih.gov/gene/?term=100130581 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000127 100130865 LOC100130865 http://www.ncbi.nlm.nih.gov/gene/?term=100130865 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000128 100130967 C6orf99 http://www.ncbi.nlm.nih.gov/gene/?term=100130967 yR211F11.1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000129 100131017 ZNF316 http://www.ncbi.nlm.nih.gov/gene/?term=100131017 "ENST00000305834, MZF-3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000130 100131187 TSTD1 http://www.ncbi.nlm.nih.gov/gene/?term=100131187 KAT mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000131 100131801 PET100 http://www.ncbi.nlm.nih.gov/gene/?term=100131801 C19orf79 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000132 100132399 GAGE12D http://www.ncbi.nlm.nih.gov/gene/?term=100132399 GAGE-12B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000133 100132596 XGY2 http://www.ncbi.nlm.nih.gov/gene/?term=100132596 "XG, XGPY, XGPY2 " lncRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00000134 100133050 LOC100133050 http://www.ncbi.nlm.nih.gov/gene/?term=100133050 lncRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00000135 100134938 UPK3BL http://www.ncbi.nlm.nih.gov/gene/?term=100134938 UPLP mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000136 100134938 UPK3BL http://www.ncbi.nlm.nih.gov/gene/?term=100134938 UPLP mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000137 10013 HDAC6 http://www.ncbi.nlm.nih.gov/gene/?term=10013 "CPBHM, HD6, JM21, PPP1R90 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000138 10013 HDAC6 http://www.ncbi.nlm.nih.gov/gene/?term=10013 "HD6, JM21, CPBHM, PPP1R90 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00000139 100141515 C17orf99 http://www.ncbi.nlm.nih.gov/gene/?term=100141515 UNQ464 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000140 100144748 KLLN http://www.ncbi.nlm.nih.gov/gene/?term=100144748 "CWS4, KILLIN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000141 100144748 KLLN http://www.ncbi.nlm.nih.gov/gene/?term=100144748 "CWS4, KILLIN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000142 10014 HDAC5 http://www.ncbi.nlm.nih.gov/gene/?term=10014 "HD5, NY-CO-9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000143 10014 HDAC5 http://www.ncbi.nlm.nih.gov/gene/?term=10014 "HD5, NY-CO-9 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00000144 100151683 RNU4ATAC http://www.ncbi.nlm.nih.gov/gene/?term=100151683 "MOPD1, RFMN1, TALS, U4ATAC, RNU4ATAC " snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000145 100151683 RNU4ATAC http://www.ncbi.nlm.nih.gov/gene/?term=100151683 "MOPD1, RFMN1, TALS, U4ATAC, RNU4ATAC " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000146 100151684 RNU6ATAC http://www.ncbi.nlm.nih.gov/gene/?term=100151684 "RNU6ATAC1, U6ATAC " snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000147 100151688 RNU6ATAC5P http://www.ncbi.nlm.nih.gov/gene/?term=100151688 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000148 100152093 PENK http://www.ncbi.nlm.nih.gov/gene/?term=100152093 mRNA Cavia porcellus 8269474 Endoplasmic reticulum Neuron In situ hybridization "Proenkephalin mRNAs were clearly localized within circumscribed cytoplasmic compartments. The immunoprecipitates were mainly observed within the rough endoplasmic reticulum, especially at the periphery of the cell. " RLID00000149 100158262 SCARNA9L http://www.ncbi.nlm.nih.gov/gene/?term=100158262 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00000150 100158262 SCARNA9L http://www.ncbi.nlm.nih.gov/gene/?term=100158262 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00000151 100158262 SCARNA9L http://www.ncbi.nlm.nih.gov/gene/?term=100158262 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "On the other hand, sdRNAs of only three Cajal body snoRNAs (SCARNA6, SCARNA15, SCARNA9L2) were represented in the subcellular libraries. " RLID00000152 100158449 magi1 http://www.ncbi.nlm.nih.gov/gene/?term=100158449 "aip3, baiap1, bap1, magi-1, tnrc19, wwp3 " mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00000153 10015 PDCD6IP http://www.ncbi.nlm.nih.gov/gene/?term=10015 "AIP1, ALIX, DRIP4, HP95 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000154 10015 PDCD6IP http://www.ncbi.nlm.nih.gov/gene/?term=10015 "AIP1, ALIX, DRIP4, HP95 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000155 10015 PDCD6IP http://www.ncbi.nlm.nih.gov/gene/?term=10015 "AIP1, ALIX, DRIP4, HP95 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000156 100169751 RNA5S1 http://www.ncbi.nlm.nih.gov/gene/?term=100169751 RN5S1 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000157 100169751 RNA5S1 http://www.ncbi.nlm.nih.gov/gene/?term=100169751 RN5S1 rRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00000158 100169751 RNA5S1 http://www.ncbi.nlm.nih.gov/gene/?term=100169751 RN5S1 rRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000159 100169751 RNA5S1 http://www.ncbi.nlm.nih.gov/gene/?term=100169751 RN5S1 rRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000160 100169753 RNA5S2 http://www.ncbi.nlm.nih.gov/gene/?term=100169753 RN5S2 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000161 100169754 RNA5S3 http://www.ncbi.nlm.nih.gov/gene/?term=100169754 RN5S3 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000162 100169754 RNA5S3 http://www.ncbi.nlm.nih.gov/gene/?term=100169754 RN5S3 rRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00000163 100169755 RNA5S4 http://www.ncbi.nlm.nih.gov/gene/?term=100169755 RN5S4 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000164 100169756 RNA5S5 http://www.ncbi.nlm.nih.gov/gene/?term=100169756 RN5S5 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000165 100169757 RNA5S6 http://www.ncbi.nlm.nih.gov/gene/?term=100169757 RN5S6 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000166 100169758 RNA5S7 http://www.ncbi.nlm.nih.gov/gene/?term=100169758 RN5S7 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000167 100169759 RNA5S8 http://www.ncbi.nlm.nih.gov/gene/?term=100169759 RN5S8 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000168 100169761 RNA5S10 http://www.ncbi.nlm.nih.gov/gene/?term=100169761 RN5S10 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000169 100169762 RNA5S11 http://www.ncbi.nlm.nih.gov/gene/?term=100169762 RN5S11 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000170 100169763 RNA5S12 http://www.ncbi.nlm.nih.gov/gene/?term=100169763 RN5S12 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000171 100169764 RNA5S13 http://www.ncbi.nlm.nih.gov/gene/?term=100169764 RN5S13 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000172 100169765 RNA5S14 http://www.ncbi.nlm.nih.gov/gene/?term=100169765 RN5S14 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000173 100169766 RNA5S15 http://www.ncbi.nlm.nih.gov/gene/?term=100169766 RN5S15 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000174 100169767 RNA5S16 http://www.ncbi.nlm.nih.gov/gene/?term=100169767 RN5S16 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000175 100169768 RNA5S17 http://www.ncbi.nlm.nih.gov/gene/?term=100169768 RN5S17 rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000176 100169879 Gm11117 http://www.ncbi.nlm.nih.gov/gene/?term=100169879 ENSMUSG00000079441 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000177 100169 Phactr4 http://www.ncbi.nlm.nih.gov/gene/?term=100169 "3110001B12Rik, AI527228, AW495572, C330013F19Rik, N28169, mKIAA4120 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000178 10016 PDCD6 http://www.ncbi.nlm.nih.gov/gene/?term=10016 "ALG-2, ALG2, PEF1B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000179 100170550 ano1 http://www.ncbi.nlm.nih.gov/gene/?term=100170550 "dog1, oraov2, taos2, tmem16a " mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00000180 100177 Zmym6 http://www.ncbi.nlm.nih.gov/gene/?term=100177 "9330177P20Rik, AI593204, AI661340, D4Wsu24e, Zfp258 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000181 10017 BCL2L10 http://www.ncbi.nlm.nih.gov/gene/?term=10017 "BCL-B, Boo, Diva, bcl2-L-10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000182 100188986 TRH-GTG1-7 http://www.ncbi.nlm.nih.gov/gene/?term=100188986 "TRH-GTG1-5, TRNAH1 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000183 100188987 TRH-GTG1-5 http://www.ncbi.nlm.nih.gov/gene/?term=100188987 "TRH-GTG1-8, TRNAH3 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000184 100188988 TRH-GTG1-8 http://www.ncbi.nlm.nih.gov/gene/?term=100188988 "TRH-GTG1-6, TRNAH2 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000185 100188991 TRH-GTG1-1 http://www.ncbi.nlm.nih.gov/gene/?term=100188991 TRNAH4 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000186 100188993 TRV-TAC1-1 http://www.ncbi.nlm.nih.gov/gene/?term=100188993 TRNAV11 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000187 100189015 TRX-CAT1-1 http://www.ncbi.nlm.nih.gov/gene/?term=100189015 TRNAM3 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000188 100189030 TRE-TTC2-1 http://www.ncbi.nlm.nih.gov/gene/?term=100189030 TRNAE7 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000189 100189040 TRX-CAT1-4 http://www.ncbi.nlm.nih.gov/gene/?term=100189040 "TRNAM4, TRX-CAT1-5 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000190 100189063 TRE-TTC2-2 http://www.ncbi.nlm.nih.gov/gene/?term=100189063 TRNAE11 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000191 100189065 TRH-GTG1-9 http://www.ncbi.nlm.nih.gov/gene/?term=100189065 "TRH-GTG1-7, TRNAH6 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000192 100189094 TRX-CAT1-3 http://www.ncbi.nlm.nih.gov/gene/?term=100189094 "TRNAM6, TRX-CAT1-4 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000193 100189120 TRD-GTC2-5 http://www.ncbi.nlm.nih.gov/gene/?term=100189120 TRNAD5 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000194 100189122 TRK-TTT3-1 http://www.ncbi.nlm.nih.gov/gene/?term=100189122 TRNAK16 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000195 100189134 TRD-GTC2-4 http://www.ncbi.nlm.nih.gov/gene/?term=100189134 TRNAD6 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000196 100189144 TRC-GCA1-1 http://www.ncbi.nlm.nih.gov/gene/?term=100189144 TRNAC10 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000197 100189151 TRL-TAG2-1 http://www.ncbi.nlm.nih.gov/gene/?term=100189151 TRNAL15 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000198 100189158 TRD-GTC2-6 http://www.ncbi.nlm.nih.gov/gene/?term=100189158 "TRD-GTC2-10, TRNAD8 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000199 100189160 TRG-GCC1-4 http://www.ncbi.nlm.nih.gov/gene/?term=100189160 TRNAG15 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000200 100189174 TRH-GTG1-4 http://www.ncbi.nlm.nih.gov/gene/?term=100189174 TRNAH7 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000201 100189191 TRV-TAC1-2 http://www.ncbi.nlm.nih.gov/gene/?term=100189191 TRNAV19 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000202 100189207 TRD-GTC1-1 http://www.ncbi.nlm.nih.gov/gene/?term=100189207 TRNAD10 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000203 100189230 TRG-GCC1-3 http://www.ncbi.nlm.nih.gov/gene/?term=100189230 TRNAG21 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000204 100189231 TRG-CCC2-1 http://www.ncbi.nlm.nih.gov/gene/?term=100189231 "TRG-CCC2-2, TRNAG22 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000205 100189234 TRK-TTT3-3 http://www.ncbi.nlm.nih.gov/gene/?term=100189234 "TRK-TTT3-5, TRNAK22 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000206 100189235 TRD-GTC2-2 http://www.ncbi.nlm.nih.gov/gene/?term=100189235 TRNAD11 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000207 100189237 TRL-CAA1-2 http://www.ncbi.nlm.nih.gov/gene/?term=100189237 TRNAL22 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000208 100189239 TRD-GTC2-8 http://www.ncbi.nlm.nih.gov/gene/?term=100189239 "TRD-GTC2-6, TRNAD12 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000209 100189243 TRR-ACG1-3 http://www.ncbi.nlm.nih.gov/gene/?term=100189243 "TRNAR21, TRR-ACG1-1 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000210 100189252 TRG-GCC1-2 http://www.ncbi.nlm.nih.gov/gene/?term=100189252 TRNAG23 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000211 100189255 TRX-CAT1-8 http://www.ncbi.nlm.nih.gov/gene/?term=100189255 "TRNAM14, TRX-CAT1-2 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000212 100189283 TRV-TAC2-1 http://www.ncbi.nlm.nih.gov/gene/?term=100189283 TRNAV23 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000213 100189284 TRG-GCC1-5 http://www.ncbi.nlm.nih.gov/gene/?term=100189284 TRNAG27 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000214 100189286 TRP-TGG1-1 http://www.ncbi.nlm.nih.gov/gene/?term=100189286 TRNAP17 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000215 100189290 TRD-GTC2-3 http://www.ncbi.nlm.nih.gov/gene/?term=100189290 TRNAD13 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000216 100189292 TRD-GTC2-7 http://www.ncbi.nlm.nih.gov/gene/?term=100189292 "TRD-GTC2-11, TRNAD14 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000217 100189297 TRX-CAT1-6 http://www.ncbi.nlm.nih.gov/gene/?term=100189297 "TRNAM15, TRX-CAT1-7 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000218 100189307 TRH-GTG1-3 http://www.ncbi.nlm.nih.gov/gene/?term=100189307 TRNAH9 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000219 100189313 TRL-TAA1-1 http://www.ncbi.nlm.nih.gov/gene/?term=100189313 TRNAL29 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000220 100189315 TRX-CAT1-7 http://www.ncbi.nlm.nih.gov/gene/?term=100189315 "TRNAM17, TRX-CAT1-8 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000221 100189333 TRE-TTC1-2 http://www.ncbi.nlm.nih.gov/gene/?term=100189333 "TRE-TTC1-1, TRNAE20 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000222 100189334 TRH-GTG1-2 http://www.ncbi.nlm.nih.gov/gene/?term=100189334 TRNAH10 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000223 100189343 TRD-GTC2-9 http://www.ncbi.nlm.nih.gov/gene/?term=100189343 "TRD-GTC2-7, TRNAD15 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000224 100189345 TRX-CAT1-5 http://www.ncbi.nlm.nih.gov/gene/?term=100189345 "TRNAM18, TRX-CAT1-6 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000225 100189347 TRD-GTC2-10 http://www.ncbi.nlm.nih.gov/gene/?term=100189347 "TRD-GTC2-8, TRNAD16 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000226 100189366 TRG-GCC1-1 http://www.ncbi.nlm.nih.gov/gene/?term=100189366 TRNAG30 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000227 100189383 TRD-GTC2-11 http://www.ncbi.nlm.nih.gov/gene/?term=100189383 "TRD-GTC2-9, TRNAD17 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000228 100189396 TRR-ACG1-1 http://www.ncbi.nlm.nih.gov/gene/?term=100189396 "TRNAR26, TRR-ACG1-2 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000229 100189412 TRD-GTC2-1 http://www.ncbi.nlm.nih.gov/gene/?term=100189412 TRNAD18 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000230 100189416 TRV-CAC3-1 http://www.ncbi.nlm.nih.gov/gene/?term=100189416 TRNAV32 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000231 100189425 TRK-TTT3-2 http://www.ncbi.nlm.nih.gov/gene/?term=100189425 TRNAK34 tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000232 10019 SH2B3 http://www.ncbi.nlm.nih.gov/gene/?term=10019 "IDDM20, LNK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000233 10019 SH2B3 http://www.ncbi.nlm.nih.gov/gene/?term=10019 "IDDM20, LNK " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000234 10019 SH2B3 http://www.ncbi.nlm.nih.gov/gene/?term=10019 "IDDM20, LNK " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000235 1001 CDH3 http://www.ncbi.nlm.nih.gov/gene/?term=1001 "CDHP, HJMD, PCAD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000236 1001 CDH3 http://www.ncbi.nlm.nih.gov/gene/?term=1001 "CDHP, HJMD, PCAD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000237 100206 Adprhl2 http://www.ncbi.nlm.nih.gov/gene/?term=100206 "AI836109, Arh3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000238 10020 GNE http://www.ncbi.nlm.nih.gov/gene/?term=10020 "DMRV, GLCNE, IBM2, NM, Uae1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000239 10020 GNE http://www.ncbi.nlm.nih.gov/gene/?term=10020 "DMRV, GLCNE, IBM2, NM, Uae1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000240 10020 GNE http://www.ncbi.nlm.nih.gov/gene/?term=10020 "DMRV, GLCNE, IBM2, NM, Uae1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000241 10020 GNE http://www.ncbi.nlm.nih.gov/gene/?term=10020 "DMRV, GLCNE, IBM2, NM, Uae1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000242 100210 Gpn2 http://www.ncbi.nlm.nih.gov/gene/?term=100210 "AI838661, Atpbd1b, R74630 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000243 100216200 pld2 http://www.ncbi.nlm.nih.gov/gene/?term=100216200 mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00000244 100216343 Gm17501 http://www.ncbi.nlm.nih.gov/gene/?term=100216343 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000245 10023 FRAT1 http://www.ncbi.nlm.nih.gov/gene/?term=10023 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000246 10024 TROAP http://www.ncbi.nlm.nih.gov/gene/?term=10024 TASTIN mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000247 10024 TROAP http://www.ncbi.nlm.nih.gov/gene/?term=10024 TASTIN mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000248 10024 TROAP http://www.ncbi.nlm.nih.gov/gene/?term=10024 TASTIN mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000249 10025 MED16 http://www.ncbi.nlm.nih.gov/gene/?term=10025 "DRIP92, THRAP5, TRAP95 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000250 10026 PIGK http://www.ncbi.nlm.nih.gov/gene/?term=10026 GPI8 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000251 10026 PIGK http://www.ncbi.nlm.nih.gov/gene/?term=10026 GPI8 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000252 10026 PIGK http://www.ncbi.nlm.nih.gov/gene/?term=10026 GPI8 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000253 100272147 CMC4 http://www.ncbi.nlm.nih.gov/gene/?term=100272147 "C6.1B, MTCP1, MTCP1B, MTCP1NB, p8, p8MTCP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000254 100272219 AA543186 http://www.ncbi.nlm.nih.gov/gene/?term=100272219 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000255 100273 Osbpl9 http://www.ncbi.nlm.nih.gov/gene/?term=100273 "2600011I06Rik, AU015843, Orp-9 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000256 100287314 LINC00941 http://www.ncbi.nlm.nih.gov/gene/?term=100287314 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000257 100287314 LINC00941 http://www.ncbi.nlm.nih.gov/gene/?term=100287314 lncRNA Homo sapiens 25630241 Cytoplasm Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00000258 100287314 LINC00941 http://www.ncbi.nlm.nih.gov/gene/?term=100287314 lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00000259 100287569 LINC00173 http://www.ncbi.nlm.nih.gov/gene/?term=100287569 NCRNA00173 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000260 100288142 NBPF20 http://www.ncbi.nlm.nih.gov/gene/?term=100288142 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000261 100288798 LOC100288798 http://www.ncbi.nlm.nih.gov/gene/?term=100288798 lncRNA Homo sapiens 26670263 Cytoplasm HeLa cell Next-generation sequencing|qRT-PCR "The minor spliced LOC100288798 isoforms are exported to the cytoplasm, whereas the major unspliced isoform is nuclear localized. " RLID00000262 100288798 LOC100288798 http://www.ncbi.nlm.nih.gov/gene/?term=100288798 lncRNA Homo sapiens 26670263 Nucleus HeLa cell Next-generation sequencing|qRT-PCR "The minor spliced LOC100288798 isoforms are exported to the cytoplasm, whereas the major unspliced isoform is nuclear localized. " RLID00000263 100288798 LOC100288798 http://www.ncbi.nlm.nih.gov/gene/?term=100288798 lncRNA Homo sapiens 26670263 Cytoplasm KBM7 cell Next-generation sequencing|qRT-PCR "The minor spliced LOC100288798 isoforms are exported to the cytoplasm, whereas the major unspliced isoform is nuclear localized. " RLID00000264 100288798 LOC100288798 http://www.ncbi.nlm.nih.gov/gene/?term=100288798 lncRNA Homo sapiens 26670263 Nucleus KBM7 cell Next-generation sequencing|qRT-PCR "The minor spliced LOC100288798 isoforms are exported to the cytoplasm, whereas the major unspliced isoform is nuclear localized. " RLID00000265 100288801 FRG2C http://www.ncbi.nlm.nih.gov/gene/?term=100288801 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000266 100288801 FRG2C http://www.ncbi.nlm.nih.gov/gene/?term=100288801 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000267 100289635 ZNF605 http://www.ncbi.nlm.nih.gov/gene/?term=100289635 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000268 100302634 Astx6 http://www.ncbi.nlm.nih.gov/gene/?term=100302634 "Gm14949, OTTMUSG00000018579 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000269 100302738 RNU6-21P http://www.ncbi.nlm.nih.gov/gene/?term=100302738 RNU6-21 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000270 100302741 RNU6-15P http://www.ncbi.nlm.nih.gov/gene/?term=100302741 RNU6-15 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000271 100302742 RNU6-42P http://www.ncbi.nlm.nih.gov/gene/?term=100302742 RNU6-42 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000272 100302743 SNORA80B http://www.ncbi.nlm.nih.gov/gene/?term=100302743 ACA67B snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000273 100303755 PET117 http://www.ncbi.nlm.nih.gov/gene/?term=100303755 CSRP2BP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000274 100306951 PITPNA-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100306951 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000275 100329140 Mettl5os http://www.ncbi.nlm.nih.gov/gene/?term=100329140 4930550G17Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000276 100337591 SNORA70F http://www.ncbi.nlm.nih.gov/gene/?term=100337591 U70F snoRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000277 100361269 Snrpa1 http://www.ncbi.nlm.nih.gov/gene/100361269 mRNA Rattus norvegicus 11861124 Dendrite Peptidergic neuron In situ hybridization "28S rRNA, initiator tRNA(Met), and poly(A) mRNA were revealed extending into proximal and middle parts of dendrites where intensely reactive punctate structures were common. 28S rRNA could be detected in the distal parts of the dendrites. " RLID00000278 10036 CHAF1A http://www.ncbi.nlm.nih.gov/gene/?term=10036 "CAF-1, CAF1, CAF1B, CAF1P150, P150 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000279 10036 CHAF1A http://www.ncbi.nlm.nih.gov/gene/?term=10036 "CAF-1, CAF1, CAF1B, CAF1P150, P150 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000280 100379295 RNY4P8 http://www.ncbi.nlm.nih.gov/gene/?term=100379295 lncRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00000281 100379571 BACE1-AS http://www.ncbi.nlm.nih.gov/gene/?term=100379571 "BACE1-AS1, BACE1AS, NCRNA00177 " lncRNA Homo sapiens 18587408 Cytoplasm Brain Knockdown "Exposure of the SH-SY5Y cells to conditioned media from CHO-7PA2 cells, but not conditioned media from control parental CHO cells resulted in an increase in cytoplasmic concentrations of BACE1-AS transcript (Fig. 4b). " RLID00000282 100380046 atrx http://www.ncbi.nlm.nih.gov/gene/?term=100380046 rad54 mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00000283 100381270 ZBED6 http://www.ncbi.nlm.nih.gov/gene/?term=100381270 MGR mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000284 10038 PARP2 http://www.ncbi.nlm.nih.gov/gene/?term=10038 "ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000285 1003 CDH5 http://www.ncbi.nlm.nih.gov/gene/?term=1003 "7B4, CD144 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000286 10040 TOM1L1 http://www.ncbi.nlm.nih.gov/gene/?term=10040 SRCASM mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000287 100416706 Zfp729b http://www.ncbi.nlm.nih.gov/gene/?term=100416706 AA987127 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000288 10042 HMGXB4 http://www.ncbi.nlm.nih.gov/gene/?term=10042 "HMG2L1, HMGBCG, THC211630 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000289 10042 HMGXB4 http://www.ncbi.nlm.nih.gov/gene/?term=10042 "HMG2L1, HMGBCG, THC211630 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000290 100434 Slc44a1 http://www.ncbi.nlm.nih.gov/gene/?term=100434 "2210409B22Rik, 4833416H08Rik, AW547365, CHTL1, CTL1, Cdw92 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000291 10043 TOM1 http://www.ncbi.nlm.nih.gov/gene/?term=10043 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000292 10045 SH2D3A http://www.ncbi.nlm.nih.gov/gene/?term=10045 NSP1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000293 100462953 MINOS1P1 http://www.ncbi.nlm.nih.gov/gene/?term=100462953 "CG012, N4BP2L2-IT, N4BP2L2-IT1, N4BP2L2IT1 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000294 100462977 MTRNR2L1 http://www.ncbi.nlm.nih.gov/gene/?term=100462977 HN1 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000295 100462981 MTRNR2L2 http://www.ncbi.nlm.nih.gov/gene/?term=100462981 HN2 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000296 100462981 MTRNR2L2 http://www.ncbi.nlm.nih.gov/gene/?term=100462981 HN2 mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00000297 100463482 MTRNR2L6 http://www.ncbi.nlm.nih.gov/gene/?term=100463482 HN6 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000298 100463486 MTRNR2L8 http://www.ncbi.nlm.nih.gov/gene/?term=100463486 HN8 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000299 100463486 MTRNR2L8 http://www.ncbi.nlm.nih.gov/gene/?term=100463486 HN8 mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00000300 100463488 MTRNR2L10 http://www.ncbi.nlm.nih.gov/gene/?term=100463488 HN10 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000301 100465 Mob3c http://www.ncbi.nlm.nih.gov/gene/?term=100465 "AW822253, D130076I06Rik, Mobkl2c " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000302 100479 BB131254 http://www.ncbi.nlm.nih.gov/gene/?term=100479 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000303 100487162 fam109a http://www.ncbi.nlm.nih.gov/gene/?term=100487162 mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00000304 100491386 fam65a http://www.ncbi.nlm.nih.gov/gene/?term=100491386 mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00000305 100491926 mov10 http://www.ncbi.nlm.nih.gov/gene/?term=100491926 mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00000306 100495373 grip2 http://www.ncbi.nlm.nih.gov/gene/?term=100495373 "XGRIP2, Xgrip2.1 " mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00000307 100496435 armc5 http://www.ncbi.nlm.nih.gov/gene/?term=100496435 mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00000308 100498314 nat6 http://www.ncbi.nlm.nih.gov/gene/?term=100498314 "fus-2, fus2 " mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00000309 100499638 LOC100499638 http://www.ncbi.nlm.nih.gov/gene/?term=100499638 "GLYMA_13G101900, PIN2a " mRNA Solanum americanum 11785934 Cytoplasm Phloem Immunohistochemical localization|Immunoelectron microscopy "Immunohistochemical localization, using these antibodies, revealed SaPIN2a expression in external and internal phloem of stem. Immunoelectron microscopy of stem, root and leaf sections further localized SaPIN2a to the CC and predominantly to the SE, particularly the parietal cytoplasm adjacent to the cell wall, the lumen and the sieve-area pores. " RLID00000310 10049 DNAJB6 http://www.ncbi.nlm.nih.gov/gene/?term=10049 "DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, MRJ, MSJ-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000311 10049 DNAJB6 http://www.ncbi.nlm.nih.gov/gene/?term=10049 "DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, MRJ, MSJ-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000312 10049 DNAJB6 http://www.ncbi.nlm.nih.gov/gene/?term=10049 "DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, MRJ, MSJ-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000313 100500713 9530027J09Rik http://www.ncbi.nlm.nih.gov/gene/?term=100500713 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000314 100502700 AV039307 http://www.ncbi.nlm.nih.gov/gene/?term=100502700 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000315 100502841 Epg5 http://www.ncbi.nlm.nih.gov/gene/?term=100502841 "4732475F16, 5430411K18Rik, AI661957, AW456499, mKIAA1632 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000316 100502898 Gm19440 http://www.ncbi.nlm.nih.gov/gene/?term=100502898 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000317 100503120 A930006K02Rik http://www.ncbi.nlm.nih.gov/gene/?term=100503120 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000318 100503199 5430416N02Rik http://www.ncbi.nlm.nih.gov/gene/?term=100503199 "100041797, Adapt33, Gm3514 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000319 100503380 Snhg4 http://www.ncbi.nlm.nih.gov/gene/?term=100503380 Gm17457 lncRNA Mus musculus 25332394 Cytoplasm - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/snhg4/ RLID00000320 100503380 Snhg4 http://www.ncbi.nlm.nih.gov/gene/?term=100503380 Gm17457 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000321 100503463 AI256396 http://www.ncbi.nlm.nih.gov/gene/?term=100503463 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000322 100503470 Gm16619 http://www.ncbi.nlm.nih.gov/gene/?term=100503470 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000323 100503670 Rpl5 http://www.ncbi.nlm.nih.gov/gene/?term=100503670 U21RNA mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000324 100503690 Gm19835 http://www.ncbi.nlm.nih.gov/gene/?term=100503690 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000325 100503754 Gm11725 http://www.ncbi.nlm.nih.gov/gene/?term=100503754 OTTMUSG00000003731 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000326 100503859 1110015O18Rik http://www.ncbi.nlm.nih.gov/gene/?term=100503859 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000327 100503871 4833432E10Rik http://www.ncbi.nlm.nih.gov/gene/?term=100503871 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000328 100504070 Gm20043 http://www.ncbi.nlm.nih.gov/gene/?term=100504070 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000329 100504178 Dhrs13os http://www.ncbi.nlm.nih.gov/gene/?term=100504178 "A030003K02Rik, AA682085 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000330 100504262 A730020E08Rik http://www.ncbi.nlm.nih.gov/gene/?term=100504262 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000331 100504455 Gm15834 http://www.ncbi.nlm.nih.gov/gene/?term=100504455 "C130065N10Rik, OTTMUSG00000026620 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000332 100504527 Gm10374 http://www.ncbi.nlm.nih.gov/gene/?term=100504527 ENSMUSG00000072593 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000333 100504663 Atg14 http://www.ncbi.nlm.nih.gov/gene/?term=100504663 "4832427M01L, D14Ertd114e, D14Ertd436e, Atg14 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000334 100505641 FGD5-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100505641 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000335 100505761 RPARP-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100505761 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000336 100505817 LOC100505817 http://www.ncbi.nlm.nih.gov/gene/?term=100505817 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000337 100505876 CEBPZOS http://www.ncbi.nlm.nih.gov/gene/?term=100505876 CEBPZ-AS1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000338 100505894 TMEM161B-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100505894 linc-POLR3G-8 lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00000339 100505989 LINC01207 http://www.ncbi.nlm.nih.gov/gene/?term=100505989 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000340 100506054 RNASEH1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506054 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000341 100506190 LINC00963 http://www.ncbi.nlm.nih.gov/gene/?term=100506190 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000342 100506233 RAB30-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506233 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000343 100506233 RAB30-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506233 lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00000344 100506233 RAB30-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506233 lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00000345 100506365 OTUD6B-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506365 GS1-251I9.4 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000346 100506385 LINC01426 http://www.ncbi.nlm.nih.gov/gene/?term=100506385 lincRNA-uc002yug.2 lncRNA Homo sapiens 25486427 Nucleus TE-1|Eca-109 Fluorescence in situ hybridization "It revealed that most of the lincRNA-uc002yug.2 was detected in the nuclear fraction (Figure 2a). RNA fluorescence in situ hybridization (RNA FISH) using specific probes for lincRNA-uc002yug.2 transcript (red) and RUNX1 pre-mRNA (green) in Eca-109 (Supplementary Figure 2A) and TE-1 (Figure 2c) cells showed the localization of lincRNA-uc002yug.2 transcript and RUNX1 pre-mRNA, and lincRNA-uc002yug.2 was predominantly present in the nucleus. " RLID00000347 100506668 NRAV http://www.ncbi.nlm.nih.gov/gene/?term=100506668 "DYNLL1-AS1, DYNLL1AS1 " lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000348 100506714 NUP50-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506714 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000349 100507246 SNHG16 http://www.ncbi.nlm.nih.gov/gene/?term=100507246 ncRAN lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000350 100507303 SNHG19 http://www.ncbi.nlm.nih.gov/gene/?term=100507303 SNORD60HG lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000351 100507316 MINCR http://www.ncbi.nlm.nih.gov/gene/?term=100507316 LINC01604 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000352 100507428 LINC00458 http://www.ncbi.nlm.nih.gov/gene/?term=100507428 LncRNA-ES3 lncRNA Homo sapiens 22193719 Nucleus Embryonic stem cell qRT-PCR|Microarray "By means of RNA fractionation followed by quantitative PCR (qPCR), we found that lncRNA_ES1, lncRNA_ES2 and lncRNA_ES3 were preferentially retained in the nucleus (Figure 5A). " RLID00000353 100507436 MICA http://www.ncbi.nlm.nih.gov/gene/?term=100507436 "MIC-A, PERB11.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000354 100507436 MICA http://www.ncbi.nlm.nih.gov/gene/?term=100507436 "MIC-A, PERB11.1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000355 100507436 MICA http://www.ncbi.nlm.nih.gov/gene/?term=100507436 "MIC-A, PERB11.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000356 100515 Zfp518b http://www.ncbi.nlm.nih.gov/gene/?term=100515 "6820424L24Rik, AA410078, AI661722, Znf518b " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000357 10051 SMC4 http://www.ncbi.nlm.nih.gov/gene/?term=10051 "CAP-C, CAPC, SMC-4L1, hCAP-C, SMC4 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000358 10051 SMC4 http://www.ncbi.nlm.nih.gov/gene/?term=10051 "CAP-C, CAPC, SMC-4L1, hCAP-C, SMC4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000359 10051 SMC4 http://www.ncbi.nlm.nih.gov/gene/?term=10051 "CAP-C, CAPC, SMC-4, SMC4L1, hCAP-C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000360 10052 GJC1 http://www.ncbi.nlm.nih.gov/gene/?term=10052 "CX45, GJA7 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000361 10052 GJC1 http://www.ncbi.nlm.nih.gov/gene/?term=10052 "CX45, GJA7 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000362 10052 GJC1 http://www.ncbi.nlm.nih.gov/gene/?term=10052 "CX45, GJA7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000363 100532 Rell1 http://www.ncbi.nlm.nih.gov/gene/?term=100532 AA536743 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000364 100534641 Gm13856 http://www.ncbi.nlm.nih.gov/gene/?term=100534641 OTTMUSG00000014774 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000365 10053 AP1M2 http://www.ncbi.nlm.nih.gov/gene/?term=10053 "AP1-mu2, HSMU1B, MU-1B, MU1B, mu2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000366 10054 UBA2 http://www.ncbi.nlm.nih.gov/gene/?term=10054 "ARX, HRIHFB2115, SAE2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000367 10055 SAE1 http://www.ncbi.nlm.nih.gov/gene/?term=10055 "AOS1, HSPC140, SUA1, UBLE1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000368 100568459 Bc1 http://www.ncbi.nlm.nih.gov/gene/?term=100568459 Gm24367 lncRNA Mus musculus 18410515 Synapse ForeBrain qRT-PCR|Microarray "Figure 8: Within synaptoneurosomes, BC1 RNA and mature miR-124a are predominantly soluble components. Data are collected from Figure 8. " RLID00000369 10057 ABCC5 http://www.ncbi.nlm.nih.gov/gene/?term=10057 "ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000370 10057 ABCC5 http://www.ncbi.nlm.nih.gov/gene/?term=10057 "ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000371 10059 DNM1L http://www.ncbi.nlm.nih.gov/gene/?term=10059 "DLP1, DRP1, DVLP, DYMPLE, EMPF, HDYNIV " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000372 10059 DNM1L http://www.ncbi.nlm.nih.gov/gene/?term=10059 "DLP1, DRP1, DVLP, DYMPLE, EMPF, HDYNIV " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000373 10059 DNM1L http://www.ncbi.nlm.nih.gov/gene/?term=10059 "DLP1, DRP1, DVLP, DYMPLE, EMPF, HDYNIV " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000374 100609 Nsun5 http://www.ncbi.nlm.nih.gov/gene/?term=100609 "9830109N13Rik, AI326939, Nol1r, Wbscr20, Wbscr20a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000375 10061 ABCF2 http://www.ncbi.nlm.nih.gov/gene/?term=10061 "ABC28, EST133090, HUSSY-18, HUSSY18 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000376 10061 ABCF2 http://www.ncbi.nlm.nih.gov/gene/?term=10061 "ABC28, EST133090, HUSSY-18, HUSSY18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000377 10062 NR1H3 http://www.ncbi.nlm.nih.gov/gene/?term=10062 "LXR-a, LXRA, RLD-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000378 10062 NR1H3 http://www.ncbi.nlm.nih.gov/gene/?term=10062 "LXR-a, LXRA, RLD-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000379 10063 COX17 http://www.ncbi.nlm.nih.gov/gene/?term=10063 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000380 10063 COX17 http://www.ncbi.nlm.nih.gov/gene/?term=10063 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000381 10063 COX17 http://www.ncbi.nlm.nih.gov/gene/?term=10063 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000382 100642175 SPRY4-IT1 http://www.ncbi.nlm.nih.gov/gene/?term=100642175 SPRIGHTLY lncRNA Homo sapiens 21558391 Cytoplasm Melanoma cell In situ hybridization "RNA-FISH analysis showed that SPRY4-IT1 is predominantly localized in the cytoplasm of melanoma cells, and SPRY4-IT1 RNAi knockdown results in defects in cell growth, differentiation, and higher rates of apoptosis in melanoma cell lines. " RLID00000383 100652748 TIMM23B http://www.ncbi.nlm.nih.gov/gene/?term=100652748 "TIMM23, bA592B15.7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000384 100652781 SNX29P1 http://www.ncbi.nlm.nih.gov/gene/?term=100652781 "RUNDC2B, RUNDC2L " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000385 100652781 SNX29P1 http://www.ncbi.nlm.nih.gov/gene/?term=100652781 "RUNDC2B, RUNDC2L " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000386 10066 SCAMP2 http://www.ncbi.nlm.nih.gov/gene/?term=10066 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000387 10066 SCAMP2 http://www.ncbi.nlm.nih.gov/gene/?term=10066 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000388 10066 SCAMP2 http://www.ncbi.nlm.nih.gov/gene/?term=10066 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000389 10067 SCAMP3 http://www.ncbi.nlm.nih.gov/gene/?term=10067 C1orf3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000390 10067 SCAMP3 http://www.ncbi.nlm.nih.gov/gene/?term=10067 C1orf3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000391 10067 SCAMP3 http://www.ncbi.nlm.nih.gov/gene/?term=10067 C1orf3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000392 100682913 PI4K2B http://www.ncbi.nlm.nih.gov/gene/?term=100682913 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00000393 100683775 RPS15A http://www.ncbi.nlm.nih.gov/gene/?term=100683775 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00000394 100683 Trrap http://www.ncbi.nlm.nih.gov/gene/?term=100683 AI481500 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000395 100684006 DNAJC24 http://www.ncbi.nlm.nih.gov/gene/?term=100684006 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00000396 100685242 UBE2G1 http://www.ncbi.nlm.nih.gov/gene/?term=100685242 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00000397 100686016 POLR1D http://www.ncbi.nlm.nih.gov/gene/?term=100686016 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00000398 100686627 RYR3 http://www.ncbi.nlm.nih.gov/gene/?term=100686627 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00000399 100687033 NDUFB6 http://www.ncbi.nlm.nih.gov/gene/?term=100687033 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00000400 100687634 IDI1 http://www.ncbi.nlm.nih.gov/gene/?term=100687634 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00000401 100687992 HOXD8 http://www.ncbi.nlm.nih.gov/gene/?term=100687992 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00000402 100688743 TAF13 http://www.ncbi.nlm.nih.gov/gene/?term=100688743 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00000403 100689050 Adapt15 http://www.ncbi.nlm.nih.gov/gene/?term=100689050 Gadd7 lncRNA Cricetulus griseus 25332394 Cytoplasm - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/Gadd7/ RLID00000404 100689062 Xbp1 http://www.ncbi.nlm.nih.gov/gene/?term=100689062 "I79_012500, Xbp-1 " mRNA Cricetulus griseus 16644724 Cytoplasm Ovary cell RT-PCR|Northern blot "Using cell lines that continuously or transiently express these reporter constructs, we show that cytoplasmic unspliced XBP1 mRNA is efficiently spliced by activated IRE1alpha and requires ongoing cellular transcription but not active translation. Analysis of nuclear and cytoplasmic RNA fractions demonstrated that XBP1 mRNA splicing occurs in the cytoplasm. The results show that 5�capped and 3�poly(A)-tailed XBP1 mRNAs directly delivered into the cytoplasm can be efficient substrates for UPR-dependent XBP1 intron removal. " RLID00000405 100689062 Xbp1 http://www.ncbi.nlm.nih.gov/gene/?term=100689062 "I79_012500, Xbp-1 " mRNA Cricetulus griseus 16644724 Nucleus Ovary cell RT-PCR|Northern blot "FIGURE 5. XBP1 mRNA splicing occurs in the cytoplasm. CHO/mXBP1ΔC(un)-d2EGFP reporter cells were treated with Tm for 4 h and then RNAs were isolated from total (T), nuclear (N), and cytoplasmic (C) fractions and used for RT-PCR analysis (A). To demonstrate the quality of the fractionation, nucleoplasmic (N) and cytoplasmic (C) RNAs were monitored by Northern blot analysis for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (B), tRNALys (C), and U6 small nuclear RNA (D). All RNAs shown were isolated from the same experiment. GADPH is shown as a loading control (E). The image of RNA stained with ethidium bromide in a formaldehyde/agarose gel demonstrates the quality of the RNA. N.B. indicates Northern blot. " RLID00000406 100689703 9330133O14Rik http://www.ncbi.nlm.nih.gov/gene/?term=100689703 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000407 10069 RWDD2B http://www.ncbi.nlm.nih.gov/gene/?term=10069 "C21orf6, GL011 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000408 1006 CDH8 http://www.ncbi.nlm.nih.gov/gene/?term=1006 Nbla04261 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000409 100710 Pds5b http://www.ncbi.nlm.nih.gov/gene/?term=100710 "AI646570, AS3, AW212954, Aprin, mKIAA0979 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000410 10071 MUC12 http://www.ncbi.nlm.nih.gov/gene/?term=10071 "MUC-11, MUC-12, MUC11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000411 10072 DPP3 http://www.ncbi.nlm.nih.gov/gene/?term=10072 DPPIII mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000412 100736557 Gapdh http://www.ncbi.nlm.nih.gov/gene/?term=100736557 "I79_001391, GAPD " mRNA Cricetulus griseus 16644724 Nucleus Ovary cell RT-PCR|Northern blot "FIGURE 5. XBP1 mRNA splicing occurs in the cytoplasm. CHO/mXBP1ΔC(un)-d2EGFP reporter cells were treated with Tm for 4 h and then RNAs were isolated from total (T), nuclear (N), and cytoplasmic (C) fractions and used for RT-PCR analysis (A). To demonstrate the quality of the fractionation, nucleoplasmic (N) and cytoplasmic (C) RNAs were monitored by Northern blot analysis for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (B), tRNALys (C), and U6 small nuclear RNA (D). All RNAs shown were isolated from the same experiment. GADPH is shown as a loading control (E). The image of RNA stained with ethidium bromide in a formaldehyde/agarose gel demonstrates the quality of the RNA. N.B. indicates Northern blot. " RLID00000413 100736557 Gapdh http://www.ncbi.nlm.nih.gov/gene/?term=100736557 "I79_001391, GAPD " mRNA Cricetulus griseus 16644724 Cytoplasm Ovary cell RT-PCR|Northern blot "FIGURE 5. XBP1 mRNA splicing occurs in the cytoplasm. CHO/mXBP1ΔC(un)-d2EGFP reporter cells were treated with Tm for 4 h and then RNAs were isolated from total (T), nuclear (N), and cytoplasmic (C) fractions and used for RT-PCR analysis (A). To demonstrate the quality of the fractionation, nucleoplasmic (N) and cytoplasmic (C) RNAs were monitored by Northern blot analysis for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (B), tRNALys (C), and U6 small nuclear RNA (D). All RNAs shown were isolated from the same experiment. GADPH is shown as a loading control (E). The image of RNA stained with ethidium bromide in a formaldehyde/agarose gel demonstrates the quality of the RNA. N.B. indicates Northern blot. " RLID00000414 100737 Dcun1d4 http://www.ncbi.nlm.nih.gov/gene/?term=100737 AI836376 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000415 10073 SNUPN http://www.ncbi.nlm.nih.gov/gene/?term=10073 "KPNBL, RNUT1, Snurportin1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000416 10073 SNUPN http://www.ncbi.nlm.nih.gov/gene/?term=10073 "KPNBL, RNUT1, Snurportin1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000417 100750237 TG http://www.ncbi.nlm.nih.gov/gene/?term=100750237 mRNA Capra hircus 272676 Cytoplasm Thyroids Next-generation sequencing|qRT-PCR "In regard to subcellular distribution, the relative amount of the thyroglobulin mRNA sequences from the goiter in nuclear RNA was 42% of normal, in cytoplasmic RNA was 7% of normal, and in the membrane fraction was only 1-2% of normal. Our results suggest that the lack of thyroglobulin in these goiters is due to a defect in thyroglobulin mRNA which leads to aberrant processing and/or transport of it from its site of synthesis to the endoplasmic reticulum. " RLID00000418 100750237 TG http://www.ncbi.nlm.nih.gov/gene/?term=100750237 mRNA Capra hircus 272675 Nucleus Thyroids Next-generation sequencing|qRT-PCR "In regard to subcellular distribution, the relative amount of the thyroglobulin mRNA sequences from the goiter in nuclear RNA was 42% of normal, in cytoplasmic RNA was 7% of normal, and in the membrane fraction was only 1-2% of normal. Our results suggest that the lack of thyroglobulin in these goiters is due to a defect in thyroglobulin mRNA which leads to aberrant processing and/or transport of it from its site of synthesis to the endoplasmic reticulum. " RLID00000419 10075 HUWE1 http://www.ncbi.nlm.nih.gov/gene/?term=10075 "ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MULE, URE-B1, UREB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000420 10075 HUWE1 http://www.ncbi.nlm.nih.gov/gene/?term=10075 "ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MULE, URE-B1, UREB1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000421 10075 HUWE1 http://www.ncbi.nlm.nih.gov/gene/?term=10075 "ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MULE, URE-B1, UREB1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000422 100763 Ube3c http://www.ncbi.nlm.nih.gov/gene/?term=100763 "AI853514, mKIAA0010 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000423 10076 PTPRU http://www.ncbi.nlm.nih.gov/gene/?term=10076 "FMI, PCP-2, PTP, PTP-J, PTP-PI, PTP-RO, PTPPSI, PTPRO, PTPU2, R-PTP-PSI, R-PTP-U, hPTP-J " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000424 10077 TSPAN32 http://www.ncbi.nlm.nih.gov/gene/?term=10077 "ART1, PHEMX, PHMX, TSSC6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000425 10078 TSSC4 http://www.ncbi.nlm.nih.gov/gene/?term=10078 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000426 10081 PDCD7 http://www.ncbi.nlm.nih.gov/gene/?term=10081 "ES18, HES18 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000427 100825 AU022245 http://www.ncbi.nlm.nih.gov/gene/?term=100825 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000428 10082 GPC6 http://www.ncbi.nlm.nih.gov/gene/?term=10082 OMIMD1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000429 10083 USH1C http://www.ncbi.nlm.nih.gov/gene/?term=10083 "AIE-75, DFNB18, DFNB18A, NY-CO-37, NY-CO-38, PDZ-45, PDZ-73, PDZ-73/NY-CO-38, PDZ73, PDZD7C, ush1cpst " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000430 10084 PQBP1 http://www.ncbi.nlm.nih.gov/gene/?term=10084 "MRX2, MRX55, MRXS3, MRXS8, NPW38, RENS1, SHS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000431 10085 EDIL3 http://www.ncbi.nlm.nih.gov/gene/?term=10085 DEL1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000432 100861531 Rn45s http://www.ncbi.nlm.nih.gov/gene/?term=100861531 rRNA Mus musculus 16874305 Nucleus Fibroblast qRT-PCR|Northern blot "In contrast, the nuclear localized 45S rRNA shows a mean nuclear/cytoplasmic ratio of 621:1 (Figure 6A). " RLID00000433 100861532 RNA45S5 http://www.ncbi.nlm.nih.gov/gene/?term=100861532 RN45S rRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000434 100861535 Rn28s http://www.ncbi.nlm.nih.gov/gene/100861535 rRNA Rattus norvegicus 11861124 Dendrite Peptidergic neuron In situ hybridization "28S rRNA, initiator tRNA(Met), and poly(A) mRNA were revealed extending into proximal and middle parts of dendrites where intensely reactive punctate structures were common. 28S rRNA could be detected in the distal parts of the dendrites. " RLID00000435 100861766 Gm16755 http://www.ncbi.nlm.nih.gov/gene/?term=100861766 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000436 100861869 Gm21283 http://www.ncbi.nlm.nih.gov/gene/?term=100861869 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000437 100873336 RNA5-8SP6 http://www.ncbi.nlm.nih.gov/gene/?term=100873336 RN5-8S6 rRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00000438 100873740 RNU6-31P http://www.ncbi.nlm.nih.gov/gene/?term=100873740 "RNU6-31, RNU6-6 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000439 100873745 RNU6-10P http://www.ncbi.nlm.nih.gov/gene/?term=100873745 RNU6-10 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000440 100873746 RNU6-14P http://www.ncbi.nlm.nih.gov/gene/?term=100873746 RNU6-14 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000441 100873747 RNU6-30P http://www.ncbi.nlm.nih.gov/gene/?term=100873747 RNU6-30 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000442 100873748 RNU6-33P http://www.ncbi.nlm.nih.gov/gene/?term=100873748 RNU6-33 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000443 100873749 RNU6-34P http://www.ncbi.nlm.nih.gov/gene/?term=100873749 RNU6-34 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000444 100873750 RNU6-35P http://www.ncbi.nlm.nih.gov/gene/?term=100873750 RNU6-35 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000445 100873753 RNU6-16P http://www.ncbi.nlm.nih.gov/gene/?term=100873753 RNU6-16 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000446 100873754 RNU6-19P http://www.ncbi.nlm.nih.gov/gene/?term=100873754 RNU6-19 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000447 100873755 RNU6-23P http://www.ncbi.nlm.nih.gov/gene/?term=100873755 RNU6-23 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000448 100873756 RNU6-28P http://www.ncbi.nlm.nih.gov/gene/?term=100873756 RNU6-28 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000449 100873757 RNU6-36P http://www.ncbi.nlm.nih.gov/gene/?term=100873757 RNU6-36 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000450 100873758 RNU6-39P http://www.ncbi.nlm.nih.gov/gene/?term=100873758 RNU6-39 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000451 100873759 RNU6-45P http://www.ncbi.nlm.nih.gov/gene/?term=100873759 RNU6-45 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000452 100873760 RNU6-46P http://www.ncbi.nlm.nih.gov/gene/?term=100873760 RNU6-46 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000453 100873767 RNU6-59P http://www.ncbi.nlm.nih.gov/gene/?term=100873767 RNU6-59 snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000454 100873767 RNU6-59P http://www.ncbi.nlm.nih.gov/gene/?term=100873767 RNU6-59 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000455 100873814 RNU1-17P http://www.ncbi.nlm.nih.gov/gene/?term=100873814 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000456 100873815 RNU1-18P http://www.ncbi.nlm.nih.gov/gene/?term=100873815 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000457 100873824 RNU2-7P http://www.ncbi.nlm.nih.gov/gene/?term=100873824 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000458 100873825 RNU2-6P http://www.ncbi.nlm.nih.gov/gene/?term=100873825 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000459 100873829 RNU5E-4P http://www.ncbi.nlm.nih.gov/gene/?term=100873829 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000460 100873830 RNU5A-2P http://www.ncbi.nlm.nih.gov/gene/?term=100873830 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000461 100873841 RNU5D-2P http://www.ncbi.nlm.nih.gov/gene/?term=100873841 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000462 100873860 RNU1-16P http://www.ncbi.nlm.nih.gov/gene/?term=100873860 U1.64 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000463 100873861 RNU1-19P http://www.ncbi.nlm.nih.gov/gene/?term=100873861 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000464 100873862 RNU1-21P http://www.ncbi.nlm.nih.gov/gene/?term=100873862 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000465 100873863 RNU1-22P http://www.ncbi.nlm.nih.gov/gene/?term=100873863 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000466 100874051 LZTS1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874051 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000467 100874054 FALEC http://www.ncbi.nlm.nih.gov/gene/?term=100874054 "FAL1, LINC00568, ncRNA-a1 " lncRNA Homo sapiens 22955988 Nucleus Brain Microarray "We examined the subcellular location of a number of well-known lncRNAs (Fig. 8D). Unsurprisingly, the X-chromosome inactivating transcript XIST was extremely highly enriched in the nucleus for all cells we examined (with a maximum enrichment of 273-fold in the nucleus of GM12878 cells) (Fig. 8D). Other regulatory lncRNAs such as GAS5, LINC00568 (also known as ncRNA-a1), CYP4A22-AS1 (also known as ncRNA-a3), MIAT, and MEG3 were nuclear enriched in at least two different cell types, consistent with their reported roles in gene regulation. Other transcripts, including the bifunctional transcript SRA1, which acts as both a regulatory RNA and a protein-coding sequence, have more variable subcellular location depending on cell type. As reported previously, the H19 transcript is consistently enriched in the cytoplasm, especially when comparing with the chromatin fraction (cytoplasmic/chromatin enrichment 167-fold). " RLID00000468 100874323 HOXA10-AS http://www.ncbi.nlm.nih.gov/gene/?term=100874323 HOXA-AS4 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000469 10087 COL4A3BP http://www.ncbi.nlm.nih.gov/gene/?term=10087 "CERT, CERTL, GPBP, MRD34, STARD11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000470 10087 COL4A3BP http://www.ncbi.nlm.nih.gov/gene/?term=10087 "CERT, CERTL, GPBP, MRD34, STARD11 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000471 100885779 LINC-ROR http://www.ncbi.nlm.nih.gov/gene/?term=100885779 "ROR, lincRNA-RoR " lncRNA Homo sapiens 23208419 Cytoplasm Breast|Colon In situ hybridization "Furthermore, in situ hybridization (ISH) revealed that RoR is mainly present in the cytoplasm (Supplementary information, Figure S8A). " RLID00000472 100885779 LINC-ROR http://www.ncbi.nlm.nih.gov/gene/?term=100885779 "ROR, lincRNA-RoR " lncRNA Homo sapiens 23541921 Cytoplasm Embryonic stem cell In situ hybridization "Employing a fluorescence in situ hybridization (FISH) assay, we found that the linc-RoR transcripts were abundant in the cytoplasm of self-renewing hESC cells (H1, 40 passages; X-01, 30 passages) ( Figure 1A), which supports the hypothesis that linc-RoR interacted with miRNAs in the cytoplasm. " RLID00000473 100887744 RNU6-48P http://www.ncbi.nlm.nih.gov/gene/?term=100887744 RNU6-48 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000474 100887755 TRERNA1 http://www.ncbi.nlm.nih.gov/gene/?term=100887755 "LINC00651, treRNA " lncRNA Homo sapiens 23974796 Cytoplasm A549 cell qRT-PCR "Nuclear and cytoplasm fractionation was isolated from A549 cells, and the expression of endogenous treRNA was quantified by qRT-PCR. Approximately 75% of spliced treRNA was located in the cytoplasm (Supplementary Figure S10). Data are collected from Figure S10. " RLID00000475 100887755 TRERNA1 http://www.ncbi.nlm.nih.gov/gene/?term=100887755 "LINC00651, treRNA " lncRNA Homo sapiens 23974796 Nucleus A549 cell qRT-PCR "Nuclear and cytoplasm fractionation was isolated from A549 cells, and the expression of endogenous treRNA was quantified by qRT-PCR. Approximately 75% of spliced treRNA was located in the cytoplasm (Supplementary Figure S10). Data are collected from Figure S10. " RLID00000476 10092 ARPC5 http://www.ncbi.nlm.nih.gov/gene/?term=10092 "ARC16, dJ127C7.3, p16-Arc " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000477 10092 ARPC5 http://www.ncbi.nlm.nih.gov/gene/?term=10092 "ARC16, dJ127C7.3, p16-Arc " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000478 10092 ARPC5 http://www.ncbi.nlm.nih.gov/gene/?term=10092 "ARC16, dJ127C7.3, p16-Arc " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000479 10093 ARPC4 http://www.ncbi.nlm.nih.gov/gene/?term=10093 "ARC20, P20-ARC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000480 10093 ARPC4 http://www.ncbi.nlm.nih.gov/gene/?term=10093 "ARC20, P20-ARC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000481 10093 ARPC4 http://www.ncbi.nlm.nih.gov/gene/?term=10093 "ARC20, P20-ARC " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000482 10094 ARPC3 http://www.ncbi.nlm.nih.gov/gene/?term=10094 "ARC21, p21-Arc " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000483 10094 ARPC3 http://www.ncbi.nlm.nih.gov/gene/?term=10094 "ARC21, p21-Arc " mRNA Homo sapiens 23452202 Cell leading edge Lung fibroblast qRT-PCR Our data have shown that mRNA encoding WAVE-Arp2/3-associated proteins is co-localized with foci enriched with active protein synthesis at the leading edge during cell migration (Figure 4). RLID00000484 10095 ARPC1B http://www.ncbi.nlm.nih.gov/gene/?term=10095 "ARC41, p40-ARC, p41-ARC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000485 10095 ARPC1B http://www.ncbi.nlm.nih.gov/gene/?term=10095 "ARC41, p40-ARC, p41-ARC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000486 10095 ARPC1B http://www.ncbi.nlm.nih.gov/gene/?term=10095 "ARC41, p40-ARC, p41-ARC " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000487 10096 ACTR3 http://www.ncbi.nlm.nih.gov/gene/?term=10096 ARP3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000488 100978 Nfxl1 http://www.ncbi.nlm.nih.gov/gene/?term=100978 "1700012H24Rik, AW538212, D430033A06Rik, DNABF, GCF, Gm1058, TCF9 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000489 10097 ACTR2 http://www.ncbi.nlm.nih.gov/gene/?term=10097 ARP2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000490 100986 Akap9 http://www.ncbi.nlm.nih.gov/gene/?term=100986 "5730481H23Rik, AKAP-9, AKAP450, AW545847, C79026, G1-448-15, PRKA9, mKIAA0803, mei2-5, repro12 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000491 10098 TSPAN5 http://www.ncbi.nlm.nih.gov/gene/?term=10098 "NET-4, NET4, TM4SF9, TSPAN-5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000492 10098 TSPAN5 http://www.ncbi.nlm.nih.gov/gene/?term=10098 "NET-4, NET4, TM4SF9, TSPAN-5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000493 100996579 LOC100996579 http://www.ncbi.nlm.nih.gov/gene/?term=100996579 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000494 10099 TSPAN3 http://www.ncbi.nlm.nih.gov/gene/?term=10099 "TM4-A, TM4SF8, TSPAN-3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000495 10099 TSPAN3 http://www.ncbi.nlm.nih.gov/gene/?term=10099 "TM4-A, TM4SF8, TSPAN-3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000496 10101 NUBP2 http://www.ncbi.nlm.nih.gov/gene/?term=10101 "CFD1, NBP 2, NUBP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000497 10102 TSFM http://www.ncbi.nlm.nih.gov/gene/?term=10102 "EFTS, EFTSMT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000498 10102 TSFM http://www.ncbi.nlm.nih.gov/gene/?term=10102 "EFTS, EFTSMT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000499 10103 TSPAN1 http://www.ncbi.nlm.nih.gov/gene/?term=10103 "NET1, TM4C, TM4SF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000500 101056138 Gm20619 http://www.ncbi.nlm.nih.gov/gene/?term=101056138 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000501 10105 PPIF http://www.ncbi.nlm.nih.gov/gene/?term=10105 "CYP3, CyP-M, Cyp-D, CypD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000502 10105 PPIF http://www.ncbi.nlm.nih.gov/gene/?term=10105 "CYP3, CyP-M, Cyp-D, CypD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000503 10106 CTDSP2 http://www.ncbi.nlm.nih.gov/gene/?term=10106 "OS4, PSR2, SCP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000504 10109 ARPC2 http://www.ncbi.nlm.nih.gov/gene/?term=10109 "ARC34, PNAS-139, PRO2446, p34-Arc " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000505 10109 ARPC2 http://www.ncbi.nlm.nih.gov/gene/?term=10109 "ARC34, PNAS-139, PRO2446, p34-Arc " mRNA Homo sapiens 23452202 Lamellipodium Lung fibroblast Fluorescence in situ hybridization "Rac1, ArpC2 and β-actin mRNAs co-localize with actively translating ribosomes on lamellipodia. " RLID00000506 10109 ARPC2 http://www.ncbi.nlm.nih.gov/gene/?term=10109 "ARC34, PNAS-139, PRO2446, p34-Arc " mRNA Homo sapiens 23452202 Cell leading edge Lung fibroblast qRT-PCR Our data have shown that mRNA encoding WAVE-Arp2/3-associated proteins is co-localized with foci enriched with active protein synthesis at the leading edge during cell migration (Figure 4). RLID00000507 10109 ARPC2 http://www.ncbi.nlm.nih.gov/gene/?term=10109 "ARC34, PNAS-139, PRO2446, p34-Arc " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000508 101100 Ttll3 http://www.ncbi.nlm.nih.gov/gene/?term=101100 "4833441J24Rik, AI450050 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000509 10110 SGK2 http://www.ncbi.nlm.nih.gov/gene/?term=10110 "H-SGK2, dJ138B7.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000510 101118 Tmem168 http://www.ncbi.nlm.nih.gov/gene/?term=101118 "5730526F17Rik, 8430437G11Rik, AI462344, AI504145 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000511 10111 RAD50 http://www.ncbi.nlm.nih.gov/gene/?term=10111 "NBSLD, RAD502, hRad50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000512 101122 Rpusd3 http://www.ncbi.nlm.nih.gov/gene/?term=101122 AI527266 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000513 10112 KIF20A http://www.ncbi.nlm.nih.gov/gene/?term=10112 "MKLP2, RAB6KIFL " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000514 10113 PREB http://www.ncbi.nlm.nih.gov/gene/?term=10113 SEC12 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000515 10113 PREB http://www.ncbi.nlm.nih.gov/gene/?term=10113 SEC12 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000516 101148 B630005N14Rik http://www.ncbi.nlm.nih.gov/gene/?term=101148 AI666701 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000517 10114 HIPK3 http://www.ncbi.nlm.nih.gov/gene/?term=10114 "DYRK6, FIST3, PKY, YAK1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000518 10114 HIPK3 http://www.ncbi.nlm.nih.gov/gene/?term=10114 "DYRK6, FIST3, PKY, YAK1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000519 101154644 LINCMD1 http://www.ncbi.nlm.nih.gov/gene/?term=101154644 "LINC-MD1, MIR133BHG " lncRNA Homo sapiens 22000014 Cytoplasm Myoblast RT-PCR Linc-MD1 is a long noncoding cytoplasmic RNA expressed during myoblast differentiation RLID00000520 101163732 LOC101163732 http://www.ncbi.nlm.nih.gov/gene/?term=101163732 Mitf2 mRNA Oryzias latipes 23439406 Mitochondrion Oocyte In situ hybridization "Here we report in the fish medaka (Oryzias latipes) that RNAs encoding microphthalmia-associated transcription factor (Mitf) are prominent components of the BB. By fluorescence in situ hybridization on ovarian section, we revealed that the transcripts of both mitf1 and mitf2 genes concentrated in the BB, in which they co-localized with the dazl RNA, a definitive BB marker highly conserved in vertebrates. " RLID00000521 101165733 mitf http://www.ncbi.nlm.nih.gov/gene/?term=101165733 mRNA Oryzias latipes 23439406 Mitochondrion Oocyte In situ hybridization "Here we report in the fish medaka (Oryzias latipes) that RNAs encoding microphthalmia-associated transcription factor (Mitf) are prominent components of the BB. By fluorescence in situ hybridization on ovarian section, we revealed that the transcripts of both mitf1 and mitf2 genes concentrated in the BB, in which they co-localized with the dazl RNA, a definitive BB marker highly conserved in vertebrates. " RLID00000522 10116 FEM1B http://www.ncbi.nlm.nih.gov/gene/?term=10116 "F1A-ALPHA, F1AA, FEM1-beta " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000523 101179 6430519N07Rik http://www.ncbi.nlm.nih.gov/gene/?term=101179 "AI848395, AW554807 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000524 101185 Pot1a http://www.ncbi.nlm.nih.gov/gene/?term=101185 "1500031H18Rik, AI851169, Pot1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000525 101187 Parp11 http://www.ncbi.nlm.nih.gov/gene/?term=101187 "5330431N24Rik, AI851877, ARTD11, HIN1L " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000526 101206 Tada3 http://www.ncbi.nlm.nih.gov/gene/?term=101206 "1110004B19Rik, ADA3, AI987856l, Tada3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000527 10120 ACTR1B http://www.ncbi.nlm.nih.gov/gene/?term=10120 "ARP1B, CTRN2, PC3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000528 101214 Tra2a http://www.ncbi.nlm.nih.gov/gene/?term=101214 "1500010G04Rik, AL022798, G430041M01Rik, mAWMS1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000529 10121 ACTR1A http://www.ncbi.nlm.nih.gov/gene/?term=10121 "ARP1, Arp1A, CTRN1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000530 10121 ACTR1A http://www.ncbi.nlm.nih.gov/gene/?term=10121 "ARP1, Arp1A, CTRN1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000531 10121 ACTR1A http://www.ncbi.nlm.nih.gov/gene/?term=10121 "ARP1, Arp1A, CTRN1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000532 101234261 LSINCT5 http://www.ncbi.nlm.nih.gov/gene/?term=101234261 lncRNA Homo sapiens 21532345 Nucleus Breast cancer cell|Ovarian cancer cell qRT-PCR "In this report, we demonstrate that LSINCT5 is a 2.6 Kb polyadenylated, long stress-induced non-coding transcript that is on the negative strand, localized in the nucleus and potentially transcribed by RNA polymerase III. " RLID00000533 10123 ARL4C http://www.ncbi.nlm.nih.gov/gene/?term=10123 "ARL7, LAK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000534 101240 Wdr91 http://www.ncbi.nlm.nih.gov/gene/?term=101240 "9530020G05Rik, AI987683, AU018665 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000535 101243555 PTENP1-AS http://www.ncbi.nlm.nih.gov/gene/?term=101243555 "PTENP1as, PTENpg1-asRNA " lncRNA Homo sapiens 23435381 Cytoplasm Eembryonic kidney cell qRT-PCR "Cellular fractionation showed that the spliced α and β isoforms were expressed at high levels in the cytoplasm, whereas the unspliced PTENpg1 asRNA α isoform was exclusively found in the nuclear fraction (Supplementary Fig. 2d-e). " RLID00000536 101243555 PTENP1-AS http://www.ncbi.nlm.nih.gov/gene/?term=101243555 "PTENP1as, PTENpg1-asRNA " lncRNA Homo sapiens 23435381 Nucleus Eembryonic kidney cell qRT-PCR "Cellular fractionation showed that the spliced α and β isoforms were expressed at high levels in the cytoplasm, whereas the unspliced PTENpg1 asRNA α isoform was exclusively found in the nuclear fraction (Supplementary Fig. 2d-e). " RLID00000537 10124 ARL4A http://www.ncbi.nlm.nih.gov/gene/?term=10124 ARL4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000538 10126 DNAL4 http://www.ncbi.nlm.nih.gov/gene/?term=10126 "MRMV3, PIG27 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000539 10127 ZNF263 http://www.ncbi.nlm.nih.gov/gene/?term=10127 "FPM315, ZKSCAN12, ZSCAN44 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000540 10127 ZNF263 http://www.ncbi.nlm.nih.gov/gene/?term=10127 "FPM315, ZKSCAN12, ZSCAN44 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000541 10128 LRPPRC http://www.ncbi.nlm.nih.gov/gene/?term=10128 "CLONE-23970, GP130, LRP130, LSFC " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000542 10128 LRPPRC http://www.ncbi.nlm.nih.gov/gene/?term=10128 "LSFC, GP130, LRP130, CLONE-23970 " mRNA Homo sapiens 15081402 Nucleus HeLa cell In situ hybridization "To further analyze the subcellular localization of LRP130, a nuclear/ER fraction was fractionated into the nucleoplasm (NP) and nuclear envelope (NE)/ER, and the latter was further separated into outer nuclear membrane (ONM)/ER and inner nuclear membrane (INM) by treatment with Triton X-100. LRP130 was detectable in all three fractions, and the distribution pattern was in good accordance with that known for ONM/ER proteins. Interestingly, immunostaining of HeLa cells demonstrated nuclear rim staining of LRP130, specifically at the outside of the NE and also at ER, and association of LRP130 with poly(A)(+) RNA was restricted only to the ONM/ER fraction. " RLID00000543 10128 LRPPRC http://www.ncbi.nlm.nih.gov/gene/?term=10128 "LSFC, GP130, LRP130, CLONE-23970 " mRNA Homo sapiens 15081402 Endoplasmic reticulum HeLa cell In situ hybridization "To further analyze the subcellular localization of LRP130, a nuclear/ER fraction was fractionated into the nucleoplasm (NP) and nuclear envelope (NE)/ER, and the latter was further separated into outer nuclear membrane (ONM)/ER and inner nuclear membrane (INM) by treatment with Triton X-100. LRP130 was detectable in all three fractions, and the distribution pattern was in good accordance with that known for ONM/ER proteins. Interestingly, immunostaining of HeLa cells demonstrated nuclear rim staining of LRP130, specifically at the outside of the NE and also at ER, and association of LRP130 with poly(A)(+) RNA was restricted only to the ONM/ER fraction. " RLID00000544 10128 LRPPRC http://www.ncbi.nlm.nih.gov/gene/?term=10128 "CLONE-23970, GP130, LRP130, LSFC " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000545 10128 LRPPRC http://www.ncbi.nlm.nih.gov/gene/?term=10128 "CLONE-23970, GP130, LRP130, LSFC " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000546 10128 LRPPRC http://www.ncbi.nlm.nih.gov/gene/?term=10128 "CLONE-23970, GP130, LRP130, LSFC " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000547 10128 LRPPRC http://www.ncbi.nlm.nih.gov/gene/?term=10128 "CLONE-23970, GP130, LRP130, LSFC " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000548 10130 PDIA6 http://www.ncbi.nlm.nih.gov/gene/?term=10130 "ERP5, P5, TXNDC7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000549 10131 TRAP1 http://www.ncbi.nlm.nih.gov/gene/?term=10131 "HSP 75, HSP75, HSP90L, TRAP-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000550 10131 TRAP1 http://www.ncbi.nlm.nih.gov/gene/?term=10131 "HSP 75, HSP75, HSP90L, TRAP-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000551 101340252 SNORD121B http://www.ncbi.nlm.nih.gov/gene/?term=101340252 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000552 10134 BCAP31 http://www.ncbi.nlm.nih.gov/gene/?term=10134 "6C6-AG, BAP31, CDM, DDCH, DXS1357E " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000553 10134 BCAP31 http://www.ncbi.nlm.nih.gov/gene/?term=10134 "6C6-AG, BAP31, CDM, DDCH, DXS1357E " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000554 10134 BCAP31 http://www.ncbi.nlm.nih.gov/gene/?term=10134 "6C6-AG, BAP31, CDM, DDCH, DXS1357E " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000555 101351 Eogt http://www.ncbi.nlm.nih.gov/gene/?term=101351 "A130022J15Rik, AI447490, AW214473, AW259391, Aer61 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000556 10135 NAMPT http://www.ncbi.nlm.nih.gov/gene/?term=10135 "1110035O14Rik, PBEF, PBEF1, VF, VISFATIN " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000557 10136 CELA3A http://www.ncbi.nlm.nih.gov/gene/?term=10136 "ELA3, ELA3A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000558 10137 RBM12 http://www.ncbi.nlm.nih.gov/gene/?term=10137 "HRIHFB2091, SWAN " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000559 10138 YAF2 http://www.ncbi.nlm.nih.gov/gene/?term=10138 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000560 10139 ARFRP1 http://www.ncbi.nlm.nih.gov/gene/?term=10139 "ARL18, ARP, Arp1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000561 10139 ARFRP1 http://www.ncbi.nlm.nih.gov/gene/?term=10139 "ARL18, ARP, Arp1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000562 101401 Adamts9 http://www.ncbi.nlm.nih.gov/gene/?term=101401 "1810011L16Rik, 8430403M15Rik, AW743315, E030027K14Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000563 10140 TOB1 http://www.ncbi.nlm.nih.gov/gene/?term=10140 "APRO6, PIG49, TOB, TROB, TROB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000564 10140 TOB1 http://www.ncbi.nlm.nih.gov/gene/?term=10140 "APRO6, PIG49, TOB, TROB, TROB1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000565 10140 TOB1 http://www.ncbi.nlm.nih.gov/gene/?term=10140 "APRO6, PIG49, TOB, TROB, TROB1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000566 101410538 MMP24-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101410538 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000567 10142 AKAP9 http://www.ncbi.nlm.nih.gov/gene/?term=10142 "AKAP-9, AKAP350, AKAP450, CG-NAP, HYPERION, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000568 101434 Ceacam15 http://www.ncbi.nlm.nih.gov/gene/?term=101434 "AA407838, C430002N04Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000569 10146 G3BP1 http://www.ncbi.nlm.nih.gov/gene/?term=10146 "G3BP, HDH-VIII " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000570 10146 G3BP1 http://www.ncbi.nlm.nih.gov/gene/?term=10146 "G3BP, HDH-VIII " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000571 10146 G3BP1 http://www.ncbi.nlm.nih.gov/gene/?term=10146 "G3BP, HDH-VIII " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000572 101476 Plekha1 http://www.ncbi.nlm.nih.gov/gene/?term=101476 "AA960558, C920009D07Rik, TAPP1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000573 10147 SUGP2 http://www.ncbi.nlm.nih.gov/gene/?term=10147 SFRS14 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000574 10147 SUGP2 http://www.ncbi.nlm.nih.gov/gene/?term=10147 SFRS14 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000575 10148 EBI3 http://www.ncbi.nlm.nih.gov/gene/?term=10148 "IL-27B, IL27B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000576 101490 Inpp5f http://www.ncbi.nlm.nih.gov/gene/?term=101490 "5830435P03Rik, AI115354, AW561896, SAC2, cI-27, mKIAA0966 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000577 101502 Hsd3b7 http://www.ncbi.nlm.nih.gov/gene/?term=101502 "AI195443, BB098564 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000578 10150 MBNL2 http://www.ncbi.nlm.nih.gov/gene/?term=10150 "MBLL, MBLL39, PRO2032 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000579 10150 MBNL2 http://www.ncbi.nlm.nih.gov/gene/?term=10150 "MBLL, MBLL39, PRO2032 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000580 10152 ABI2 http://www.ncbi.nlm.nih.gov/gene/?term=10152 "ABI-2, ABI2B, AIP-1, AblBP3, SSH3BP2, argBP1, argBPIA, argBPIB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000581 10152 ABI2 http://www.ncbi.nlm.nih.gov/gene/?term=10152 "ABI-2B, AIP-1, AblBP3, SSH3BP2, argBP1, argBPIA, argBPIB, ABI2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000582 10153 CEBPZ http://www.ncbi.nlm.nih.gov/gene/?term=10153 "CBF, CBF2, HSP-CBF, NOC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000583 10153 CEBPZ http://www.ncbi.nlm.nih.gov/gene/?term=10153 "CBF, CBF2, HSP-CBF, NOC1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000584 101544 Zfp575 http://www.ncbi.nlm.nih.gov/gene/?term=101544 "AI326876, Znf575 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000585 10155 TRIM28 http://www.ncbi.nlm.nih.gov/gene/?term=10155 "KAP1, PPP1R157, RNF96, TF1B, TIF1B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000586 10155 TRIM28 http://www.ncbi.nlm.nih.gov/gene/?term=10155 "KAP1, PPP1R157, RNF96, TF1B, TIF1B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000587 101565 Ccp110 http://www.ncbi.nlm.nih.gov/gene/?term=101565 "6330503K22Rik, AA415922, AI427129, AW557948, CP110 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000588 10157 AASS http://www.ncbi.nlm.nih.gov/gene/?term=10157 "LKR/SDH, LKRSDH, LORSDH " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000589 10157 AASS http://www.ncbi.nlm.nih.gov/gene/?term=10157 "LKR/SDH, LKRSDH, LORSDH " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000590 101592 Efl1 http://www.ncbi.nlm.nih.gov/gene/?term=101592 "4932434J20Rik, 6030468D11Rik, AI451340, AU019507, AU022896, D7Ertd791e, Eftud1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000591 10159 ATP6AP2 http://www.ncbi.nlm.nih.gov/gene/?term=10159 "APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, HT028, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000592 1015 CDH17 http://www.ncbi.nlm.nih.gov/gene/?term=1015 "CDH16, HPT-1, HPT1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000593 101602 AI467606 http://www.ncbi.nlm.nih.gov/gene/?term=101602 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000594 10160 FARP1 http://www.ncbi.nlm.nih.gov/gene/?term=10160 "CDEP, FARP1-IT1, PLEKHC2, PPP1R75 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000595 10160 FARP1 http://www.ncbi.nlm.nih.gov/gene/?term=10160 "CDEP-IT1, PLEKHC2, PPP1R75, FARP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000596 101613 Nlrp6 http://www.ncbi.nlm.nih.gov/gene/?term=101613 "AI504961, Avr, Nalp6, Navr, Navr/Avr, Non-AVR, Pypaf5 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000597 10162 LPCAT3 http://www.ncbi.nlm.nih.gov/gene/?term=10162 "C3F, LPCAT, LPLAT 5, LPSAT, MBOAT5, OACT5, nessy " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000598 10162 LPCAT3 http://www.ncbi.nlm.nih.gov/gene/?term=10162 "C3F, LPCAT, LPLAT 5, LPSAT, MBOAT5, OACT5, nessy " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000599 10162 LPCAT3 http://www.ncbi.nlm.nih.gov/gene/?term=10162 "C3F, LPCAT, LPLAT 5, LPSAT, MBOAT5, OACT5, nessy " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000600 10162 LPCAT3 http://www.ncbi.nlm.nih.gov/gene/?term=10162 "C3F, LPCAT, LPLAT 5, LPSAT, MBOAT5, OACT5, nessy " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000601 101631 Pwwp2b http://www.ncbi.nlm.nih.gov/gene/?term=101631 "AI594893, D7Ertd517e, D930023J19Rik, Pwwp2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000602 10163 WASF2 http://www.ncbi.nlm.nih.gov/gene/?term=10163 "IMD2, SCAR2, WASF4, WAVE2, dJ393P12.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000603 10163 WASF2 http://www.ncbi.nlm.nih.gov/gene/?term=10163 "IMD2, SCAR2, WASF4, WAVE2, dJ393P12.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000604 101646 B830008H07Rik http://www.ncbi.nlm.nih.gov/gene/?term=101646 AI662092 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000605 10165 SLC25A13 http://www.ncbi.nlm.nih.gov/gene/?term=10165 "ARALAR2, CITRIN, CTLN2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000606 10166 SLC25A15 http://www.ncbi.nlm.nih.gov/gene/?term=10166 "D13S327, HHH, ORC1, ORNT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000607 101685 Spty2d1 http://www.ncbi.nlm.nih.gov/gene/?term=101685 "5830435K17Rik, AI852426, P16H6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000608 10169 SERF2 http://www.ncbi.nlm.nih.gov/gene/?term=10169 "4F5REL, FAM2C, H4F5REL, HsT17089 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000609 10169 SERF2 http://www.ncbi.nlm.nih.gov/gene/?term=10169 "4F5REL, FAM2C, H4F5REL, HsT17089 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000610 101706 Numa1 http://www.ncbi.nlm.nih.gov/gene/?term=101706 "6720401E04Rik, AA764025, AL022610, AU014979 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000611 101715 AL023008 http://www.ncbi.nlm.nih.gov/gene/?term=101715 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000612 10171 RCL1 http://www.ncbi.nlm.nih.gov/gene/?term=10171 "RNAC, RPCL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000613 10171 RCL1 http://www.ncbi.nlm.nih.gov/gene/?term=10171 "RNAC, RPCL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000614 101739 Psip1 http://www.ncbi.nlm.nih.gov/gene/?term=101739 "AA408851, AU015605, Dfs70, Ledgfa, Ledgfb, Psip2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000615 10174 SORBS3 http://www.ncbi.nlm.nih.gov/gene/?term=10174 "SCAM-1, SCAM1, SH3D4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000616 101752218 ARPC5L http://www.ncbi.nlm.nih.gov/gene/?term=101752218 null mRNA Gallus gallus 15923655 Cell leading edge Fibroblast Fluorescence in situ hybridization "The localization of the Arp2/3 complex mRNAs is dependent on both actin filaments and microtubules, because disruption of either cytoskeletal system (with cytochalasin D and colchicine, respectively) inhibited the localization of all seven subunit mRNAs. To address these questions, double detection of two types of mRNAs simultaneously in the same cells was performed by sequential FISH-TSA. As shown in Fig. 5A-C, Arp3 mRNA appears not to be precisely colocalized with β-actin mRNA, although they both concentrate together in the protrusions. In addition, the Arp2 and Arp3 mRNAs also do not colocalize, although they are both concentrated together in the protrusions (Fig. 5D-F). " RLID00000617 10175 CNIH1 http://www.ncbi.nlm.nih.gov/gene/?term=10175 "CNIH, CNIH-1, CNIL, TGAM77 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000618 10175 CNIH1 http://www.ncbi.nlm.nih.gov/gene/?term=10175 "CNIH, CNIH-1, CNIL, TGAM77 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000619 10178782 CG31808 http://www.ncbi.nlm.nih.gov/gene/?term=10178782 "Dmel_ BcDNA:RE70695, CR31808, Dmel\CG31808, Dmel_CR31808, MRE33, RE70695 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00000620 10178964 CR42862 http://www.ncbi.nlm.nih.gov/gene/?term=10178964 "Dmel_ BcDNA:GH06422, CG13878, CG16971, CG32477, CR32477, Dmel\CR42862, Dmel_CG16971, Dmel_CR32477, anon-EST:fe1H7 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00000621 10178964 CR42862 http://www.ncbi.nlm.nih.gov/gene/?term=10178964 "Dmel_ BcDNA:GH06422, CG13878, CG16971, CG32477, CR32477, Dmel\CR42862, Dmel_CG16971, Dmel_CR32477, anon-EST:fe1H7 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00000622 10179 RBM7 http://www.ncbi.nlm.nih.gov/gene/?term=10179 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000623 1017 CDK2 http://www.ncbi.nlm.nih.gov/gene/?term=1017 "CDKN2, p33(CDK2) " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000624 101805488 CCAT2 http://www.ncbi.nlm.nih.gov/gene/?term=101805488 "LINC00873, NCCP1 " lncRNA Homo sapiens 25677908 Nucleus TE1 cell|KYSE410 cell qRT-PCR "CCAT2 was mostly upregulated in KYSE410 cell (24.7-fold upregulation) when normalized to normal esophageal epithelium cell line (HEEC) and most CCAT2 transcripts were located in nucleus (>95 %). Finally, with respect to the subcellular location, in TE1 and KYSE410 cell lines, CCAT2 was mostly located in nucleus (more than 95 %, shown in Fig. 2d). " RLID00000625 10180 RBM6 http://www.ncbi.nlm.nih.gov/gene/?term=10180 "3G2, DEF-3, DEF3, HLC-11, NY-LU-12, g16 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000626 10181 RBM5 http://www.ncbi.nlm.nih.gov/gene/?term=10181 "G15, H37, LUCA15, RMB5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000627 10181 RBM5 http://www.ncbi.nlm.nih.gov/gene/?term=10181 "G15, H37, LUCA15, RMB5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000628 10184 LHFPL2 http://www.ncbi.nlm.nih.gov/gene/?term=10184 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000629 10188 TNK2 http://www.ncbi.nlm.nih.gov/gene/?term=10188 "ACK, ACK-1, ACK1, p21cdc42Hs " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000630 10189 ALYREF http://www.ncbi.nlm.nih.gov/gene/?term=10189 "ALY, ALY/REF, BEF, REF, THOC4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000631 10190 TXNDC9 http://www.ncbi.nlm.nih.gov/gene/?term=10190 "APACD, PHLP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000632 101926933 LOC101926933 http://www.ncbi.nlm.nih.gov/gene/?term=101926933 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000633 101927167 GATA2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101927167 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000634 101927746 LOC101927746 http://www.ncbi.nlm.nih.gov/gene/?term=101927746 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000635 101928464 LOC101928464 http://www.ncbi.nlm.nih.gov/gene/?term=101928464 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000636 101928483 NALT1 http://www.ncbi.nlm.nih.gov/gene/?term=101928483 "LINC01573, MIR4674HG, NALT " lncRNA Homo sapiens 26330272 Cytoplasm T-lymphoma cell RT-PCR "We found that NALT was obviously existed in both cytoplasm and nucleus, and the expression of NALT in the nucleus was higher than that in the cytoplasm (Fig. 4B). " RLID00000637 101928483 NALT1 http://www.ncbi.nlm.nih.gov/gene/?term=101928483 "LINC01573, MIR4674HG, NALT " lncRNA Homo sapiens 26330272 Nucleus T-lymphoma cell RT-PCR "We found that NALT was obviously existed in both cytoplasm and nucleus, and the expression of NALT in the nucleus was higher than that in the cytoplasm (Fig. 4B). " RLID00000638 10193 RNF41 http://www.ncbi.nlm.nih.gov/gene/?term=10193 "FLRF, NRDP1, SBBI03 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000639 10194 TSHZ1 http://www.ncbi.nlm.nih.gov/gene/?term=10194 "CAA, NY-CO-33, SDCCAG33, TSH1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000640 101954264 RNVU1-4 http://www.ncbi.nlm.nih.gov/gene/?term=101954264 "RNU1-102, RNU1-50, RNVU1-5, vU1.4, vU1.5 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000641 101954266 RNVU1-14 http://www.ncbi.nlm.nih.gov/gene/?term=101954266 "RNU1-37, vU1.14 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000642 101954267 RNVU1-15 http://www.ncbi.nlm.nih.gov/gene/?term=101954267 "RNU1-121, RNU1-66, RNVU1-16, vU1.15, vU1.16 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000643 101954269 RNVU1-17 http://www.ncbi.nlm.nih.gov/gene/?term=101954269 "RNU1-127, vU1.17 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000644 101954271 RNU6-9 http://www.ncbi.nlm.nih.gov/gene/?term=101954271 U6-9 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000645 101954272 RNVU1-3 http://www.ncbi.nlm.nih.gov/gene/?term=101954272 "RNU1-113, RNU1-151, RNVU1-12, vU1.12, vU1.3 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000646 101954273 RNVU1-1 http://www.ncbi.nlm.nih.gov/gene/?term=101954273 "RNU1-10P, RNU1-53, RNU1P100, U1.4, U1P14, vU1.1, vU1.10, RNVU1-1 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000647 101954275 RNU6-7 http://www.ncbi.nlm.nih.gov/gene/?term=101954275 U6-7 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000648 101954276 RNVU1-6 http://www.ncbi.nlm.nih.gov/gene/?term=101954276 "RNU1-99, vU1.6 " snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000649 101954277 RNVU1-19 http://www.ncbi.nlm.nih.gov/gene/?term=101954277 "RNU1-126, RNU1-147, RNVU1-13, vU1.13, vU1.19 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000650 101954278 RNU6-8 http://www.ncbi.nlm.nih.gov/gene/?term=101954278 U6-8 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000651 10195 ALG3 http://www.ncbi.nlm.nih.gov/gene/?term=10195 "CDG1D, CDGS4, CDGS6, D16Ertd36e, NOT56L, Not56, not " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000652 10196 PRMT3 http://www.ncbi.nlm.nih.gov/gene/?term=10196 HRMT1L3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000653 10197 PSME3 http://www.ncbi.nlm.nih.gov/gene/?term=10197 "HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000654 10197 PSME3 http://www.ncbi.nlm.nih.gov/gene/?term=10197 "HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000655 101985 Usb1 http://www.ncbi.nlm.nih.gov/gene/?term=101985 AA960436 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000656 10198 MPHOSPH9 http://www.ncbi.nlm.nih.gov/gene/?term=10198 "MPP-9, MPP9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000657 101994 Champ1 http://www.ncbi.nlm.nih.gov/gene/?term=101994 "AA675043, AI116001, D8Ertd457e, D8Ertd569e, Zfp828, Znf828, mKIAA1802 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000658 10199 MPHOSPH10 http://www.ncbi.nlm.nih.gov/gene/?term=10199 "CT90, MPP10, MPP10P, PPP1R106 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000659 1019 CDK4 http://www.ncbi.nlm.nih.gov/gene/?term=1019 "CMM3, PSK-J3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000660 1019 CDK4 http://www.ncbi.nlm.nih.gov/gene/?term=1019 "CMM3, PSK-J3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000661 101 ADAM8 http://www.ncbi.nlm.nih.gov/gene/?term=101 "CD156, CD156a, MS2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000662 10200 MPHOSPH6 http://www.ncbi.nlm.nih.gov/gene/?term=10200 "MPP, MPP-6, MPP6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000663 10200 MPHOSPH6 http://www.ncbi.nlm.nih.gov/gene/?term=10200 "MPP, MPP-6, MPP6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000664 10200 MPHOSPH6 http://www.ncbi.nlm.nih.gov/gene/?term=10200 "MPP, MPP-6, MPP6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000665 10201 NME6 http://www.ncbi.nlm.nih.gov/gene/?term=10201 "IPIA-ALPHA, NDK 6, NM23-H6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000666 10202 DHRS2 http://www.ncbi.nlm.nih.gov/gene/?term=10202 "HEP27, SDR25C1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000667 10204 NUTF2 http://www.ncbi.nlm.nih.gov/gene/?term=10204 "NTF2, PP15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000668 10204 NUTF2 http://www.ncbi.nlm.nih.gov/gene/?term=10204 "NTF-2, NTF2, PP15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000669 10204 NUTF2 http://www.ncbi.nlm.nih.gov/gene/?term=10204 "NTF-2, NTF2, PP15 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000670 10205 MPZL2 http://www.ncbi.nlm.nih.gov/gene/?term=10205 "EVA, EVA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000671 10205 MPZL2 http://www.ncbi.nlm.nih.gov/gene/?term=10205 "EVA, EVA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000672 102060 Gadd45gip1 http://www.ncbi.nlm.nih.gov/gene/?term=102060 "2310040G17Rik, AI425883, Crif1, MRP-L59, Plinp1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000673 10206 TRIM13 http://www.ncbi.nlm.nih.gov/gene/?term=10206 "CAR, DLEU5, LEU5, RFP2, RNF77 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000674 10206 TRIM13 http://www.ncbi.nlm.nih.gov/gene/?term=10206 "CAR, DLEU5, LEU5, RFP2, RNF77 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000675 10206 TRIM13 http://www.ncbi.nlm.nih.gov/gene/?term=10206 "CAR, DLEU5, LEU5, RFP2, RNF77 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000676 10207 PATJ http://www.ncbi.nlm.nih.gov/gene/?term=10207 "Cipp, INADL, InaD-like, hINADL " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000677 10208 USPL1 http://www.ncbi.nlm.nih.gov/gene/?term=10208 "C13orf22, D13S106E, bA121O19.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000678 10208 USPL1 http://www.ncbi.nlm.nih.gov/gene/?term=10208 "C13orf22, D13S106E, bA121O19.1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000679 102093 Phkb http://www.ncbi.nlm.nih.gov/gene/?term=102093 AI463271 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000680 10209 EIF1 http://www.ncbi.nlm.nih.gov/gene/?term=10209 "A121, EIF-1, EIF1A, ISO1, SUI1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000681 10209 EIF1 http://www.ncbi.nlm.nih.gov/gene/?term=10209 "A121, EIF-1A, ISO1, SUI1, EIF1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000682 10209 EIF1 http://www.ncbi.nlm.nih.gov/gene/?term=10209 "A121, EIF-1A, ISO1, SUI1, EIF1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000683 1020 CDK5 http://www.ncbi.nlm.nih.gov/gene/?term=1020 "LIS7, PSSALRE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000684 1020 CDK5 http://www.ncbi.nlm.nih.gov/gene/?term=1020 "LIS7, PSSALRE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000685 1020 CDK5 http://www.ncbi.nlm.nih.gov/gene/?term=1020 "LIS7, PSSALRE " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000686 102103 Mtus1 http://www.ncbi.nlm.nih.gov/gene/?term=102103 "AI481402, ATBP135, Atip1, B430010I23Rik, B430305I03Rik, C85752, Cctsg1-440, MD44, MTSG1, mKIAA1288 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000687 10210 TOPORS http://www.ncbi.nlm.nih.gov/gene/?term=10210 "LUN, P53BP3, RP31, TP53BPL " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000688 10211 FLOT1 http://www.ncbi.nlm.nih.gov/gene/?term=10211 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000689 102124 Enkd1 http://www.ncbi.nlm.nih.gov/gene/?term=102124 "AI606951, E130303B06Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000690 10212 DDX39A http://www.ncbi.nlm.nih.gov/gene/?term=10212 "BAT1, BAT1L, DDX39, DDXL, URH49 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000691 10213 PSMD14 http://www.ncbi.nlm.nih.gov/gene/?term=10213 "PAD1, POH1, RPN11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000692 10213 PSMD14 http://www.ncbi.nlm.nih.gov/gene/?term=10213 "PAD1, POH1, RPN11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000693 10213 PSMD14 http://www.ncbi.nlm.nih.gov/gene/?term=10213 "PAD1, POH1, RPN11 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000694 102141 Snx25 http://www.ncbi.nlm.nih.gov/gene/?term=102141 "AI661919, Gm1699, Gm173, Sbbi31 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000695 10214 SSX3 http://www.ncbi.nlm.nih.gov/gene/?term=10214 CT5.3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000696 102152026 HNRNPA1 http://www.ncbi.nlm.nih.gov/gene/?term=102152026 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00000697 10217 CTDSPL http://www.ncbi.nlm.nih.gov/gene/?term=10217 "C3orf8, HYA22, PSR1, RBSP3, SCP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000698 10217 CTDSPL http://www.ncbi.nlm.nih.gov/gene/?term=10217 "C3orf8, HYA22, PSR1, RBSP3, SCP3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000699 1021 CDK6 http://www.ncbi.nlm.nih.gov/gene/?term=1021 "MCPH12, PLSTIRE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000700 1021 CDK6 http://www.ncbi.nlm.nih.gov/gene/?term=1021 "MCPH12, PLSTIRE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000701 1021 CDK6 http://www.ncbi.nlm.nih.gov/gene/?term=1021 "MCPH12, PLSTIRE " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000702 10220 GDF11 http://www.ncbi.nlm.nih.gov/gene/?term=10220 "BMP-11, BMP11 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000703 102216341 LINC01109 http://www.ncbi.nlm.nih.gov/gene/?term=102216341 lncRNA-N1 lncRNA Homo sapiens 22193719 Nucleus Embryonic stem cell qRT-PCR|Microarray "Figure 7: Neuronal lncRNAs act via diverse mechanisms. (A) Quantification of relative expression of lncRNAs in nuclear and cytoplasmic cell fractions. (B) Quantification of changes in hosted miRNAs in response to lncRNA_N2 knockdown. MiRNAs were quantified using Taqman miRNA qPCR. (C-E) RIP of lncRNAs with SUZ12 and REST antibodies. The interaction of HOTAIR with SUZ12 is a known interaction that serves as a positive control (Gupta et al, 2010). * and ** indicate P-values of <0.05 and <0.01, respectively. Data are collected from Figure 7. " RLID00000704 102216342 LINC01108 http://www.ncbi.nlm.nih.gov/gene/?term=102216342 LncRNA-ES1 lncRNA Homo sapiens 22193719 Nucleus Embryonic stem cell qRT-PCR|Microarray "By means of RNA fractionation followed by quantitative PCR (qPCR), we found that lncRNA_ES1, lncRNA_ES2 and lncRNA_ES3 were preferentially retained in the nucleus (Figure 5A). " RLID00000705 10221 TRIB1 http://www.ncbi.nlm.nih.gov/gene/?term=10221 "C8FW, GIG-2, GIG2, SKIP1, TRB-1, TRB1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000706 10223 GPA33 http://www.ncbi.nlm.nih.gov/gene/?term=10223 A33 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000707 10223 GPA33 http://www.ncbi.nlm.nih.gov/gene/?term=10223 A33 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000708 10225 CD96 http://www.ncbi.nlm.nih.gov/gene/?term=10225 TACTILE mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000709 10225 CD96 http://www.ncbi.nlm.nih.gov/gene/?term=10225 TACTILE mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000710 10226 PLIN3 http://www.ncbi.nlm.nih.gov/gene/?term=10226 "M6PRBP1, PP17, TIP47 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000711 10226 PLIN3 http://www.ncbi.nlm.nih.gov/gene/?term=10226 "M6PRBP1, PP17, TIP47 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000712 10227 MFSD10 http://www.ncbi.nlm.nih.gov/gene/?term=10227 "TETRAN, TETTRAN " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000713 10227 MFSD10 http://www.ncbi.nlm.nih.gov/gene/?term=10227 "TETRAN, TETTRAN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000714 10228 STX6 http://www.ncbi.nlm.nih.gov/gene/?term=10228 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000715 10228 STX6 http://www.ncbi.nlm.nih.gov/gene/?term=10228 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000716 10229 COQ7 http://www.ncbi.nlm.nih.gov/gene/?term=10229 "CAT5, CLK-1, CLK1, COQ10D8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000717 10229 COQ7 http://www.ncbi.nlm.nih.gov/gene/?term=10229 "CAT5, CLK-1, CLK1, COQ10D8 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000718 10229 COQ7 http://www.ncbi.nlm.nih.gov/gene/?term=10229 "CAT5, CLK-1, CLK1, COQ10D8 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000719 1022 CDK7 http://www.ncbi.nlm.nih.gov/gene/?term=1022 "CAK1, CDKN7, HCAK, MO15, STK1, p39MO15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000720 10230 NBR2 http://www.ncbi.nlm.nih.gov/gene/?term=10230 NCRNA00192 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000721 102334 Ankrd10 http://www.ncbi.nlm.nih.gov/gene/?term=102334 "4833425P12Rik, AW549277 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000722 10233 LRRC23 http://www.ncbi.nlm.nih.gov/gene/?term=10233 LRPB7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000723 10234 LRRC17 http://www.ncbi.nlm.nih.gov/gene/?term=10234 P37NB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000724 10236 HNRNPR http://www.ncbi.nlm.nih.gov/gene/?term=10236 "HNRPR, hnRNP-R " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000725 10236 HNRNPR http://www.ncbi.nlm.nih.gov/gene/?term=10236 "HNRPR, hnRNP-R " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000726 10237 SLC35B1 http://www.ncbi.nlm.nih.gov/gene/?term=10237 UGTREL1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000727 10237 SLC35B1 http://www.ncbi.nlm.nih.gov/gene/?term=10237 UGTREL1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000728 10237 SLC35B1 http://www.ncbi.nlm.nih.gov/gene/?term=10237 UGTREL1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000729 10238 DCAF7 http://www.ncbi.nlm.nih.gov/gene/?term=10238 "AN11, HAN11, SWAN-1, WDR68 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000730 10238 DCAF7 http://www.ncbi.nlm.nih.gov/gene/?term=10238 "AN11, HAN11, SWAN-1, WDR68 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000731 10238 DCAF7 http://www.ncbi.nlm.nih.gov/gene/?term=10238 "AN11, HAN11, SWAN-1, WDR68 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000732 10238 DCAF7 http://www.ncbi.nlm.nih.gov/gene/?term=10238 "AN11, HAN11, SWAN-1, WDR68 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000733 102392528 IGF1 http://www.ncbi.nlm.nih.gov/gene/?term=102392528 IGF-1 mRNA Bubalus bubalis 25304995 Cytoplasm Endothelial cell RT-PCR "A relatively high mRNA expression of IGF-I and IGF-II in early, mid- and late luteal phases with immunoreactivity mostly restricted to cytoplasm of large luteal cells indicates their autocrine role, whereas very weak immunoreactivity in endothelial cells during the mid-luteal phase indicates their paracrine role. " RLID00000734 102395378 IGF2 http://www.ncbi.nlm.nih.gov/gene/?term=102395378 IGF-II mRNA Bubalus bubalis 25304995 Cytoplasm Endothelial cell RT-PCR "A relatively high mRNA expression of IGF-I and IGF-II in early, mid- and late luteal phases with immunoreactivity mostly restricted to cytoplasm of large luteal cells indicates their autocrine role, whereas very weak immunoreactivity in endothelial cells during the mid-luteal phase indicates their paracrine role. " RLID00000735 10239 AP3S2 http://www.ncbi.nlm.nih.gov/gene/?term=10239 "AP3S3, sigma3b " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000736 10239 AP3S2 http://www.ncbi.nlm.nih.gov/gene/?term=10239 "AP3S3, sigma3b " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000737 10239 AP3S2 http://www.ncbi.nlm.nih.gov/gene/?term=10239 "AP3S3, sigma3b " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000738 10239 AP3S2 http://www.ncbi.nlm.nih.gov/gene/?term=10239 "AP3S3, sigma3b " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000739 102402 AA414992 http://www.ncbi.nlm.nih.gov/gene/?term=102402 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000740 10241 CALCOCO2 http://www.ncbi.nlm.nih.gov/gene/?term=10241 NDP52 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000741 10244 RABEPK http://www.ncbi.nlm.nih.gov/gene/?term=10244 "RAB9P40, bA65N13.1, p40 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000742 10244 RABEPK http://www.ncbi.nlm.nih.gov/gene/?term=10244 "RAB9P40, bA65N13.1, p40 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000743 10244 RABEPK http://www.ncbi.nlm.nih.gov/gene/?term=10244 "RAB9P40, bA65N13.1, p40 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000744 10245 TIMM17B http://www.ncbi.nlm.nih.gov/gene/?term=10245 "DXS9822, JM3, TIM17B " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000745 10245 TIMM17B http://www.ncbi.nlm.nih.gov/gene/?term=10245 "DXS9822, JM3, TIM17B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000746 10247 RIDA http://www.ncbi.nlm.nih.gov/gene/?term=10247 "HRSP12, P14.5, PSP, UK114 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000747 10247 RIDA http://www.ncbi.nlm.nih.gov/gene/?term=10247 "HRSP12, P14.5, PSP, UK114 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000748 10247 RIDA http://www.ncbi.nlm.nih.gov/gene/?term=10247 "HRSP12, P14.5, PSP, UK114 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000749 10248 POP7 http://www.ncbi.nlm.nih.gov/gene/?term=10248 "0610037N12Rik, RPP2, RPP20 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000750 10248 POP7 http://www.ncbi.nlm.nih.gov/gene/?term=10248 "0610037N12Rik, RPP2, RPP20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000751 1024 CDK8 http://www.ncbi.nlm.nih.gov/gene/?term=1024 K35 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000752 10250 SRRM1 http://www.ncbi.nlm.nih.gov/gene/?term=10250 "160-KD, POP101, SRM160 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000753 10253 SPRY2 http://www.ncbi.nlm.nih.gov/gene/?term=10253 "IGAN3, hSPRY2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000754 10253 SPRY2 http://www.ncbi.nlm.nih.gov/gene/?term=10253 "IGAN3, hSPRY2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000755 10254 STAM2 http://www.ncbi.nlm.nih.gov/gene/?term=10254 "Hbp, STAM2A, STAM2B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000756 10254 STAM2 http://www.ncbi.nlm.nih.gov/gene/?term=10254 "HbpA, STAM2B, STAM2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000757 10254 STAM2 http://www.ncbi.nlm.nih.gov/gene/?term=10254 "HbpA, STAM2B, STAM2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000758 10256 CNKSR1 http://www.ncbi.nlm.nih.gov/gene/?term=10256 "CNK, CNK1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000759 102577426 LOC102577426 http://www.ncbi.nlm.nih.gov/gene/?term=102577426 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000760 10257 ABCC4 http://www.ncbi.nlm.nih.gov/gene/?term=10257 "MOAT-B, MOATB, MRP4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000761 102596 AI842136 http://www.ncbi.nlm.nih.gov/gene/?term=102596 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000762 1025 CDK9 http://www.ncbi.nlm.nih.gov/gene/?term=1025 "C-2k, CDC2L4, CTK1, PITALRE, TAK " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000763 1025 CDK9 http://www.ncbi.nlm.nih.gov/gene/?term=1025 "TAK, C-2k, CTK1, CDC2L4, PITALRE " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00000764 1025 CDK9 http://www.ncbi.nlm.nih.gov/gene/?term=1025 "C-2k, CDC2L4, CTK1, PITALRE, TAK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000765 1025 CDK9 http://www.ncbi.nlm.nih.gov/gene/?term=1025 "C-2k, CDC2L4, CTK1, PITALRE, TAK " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00000766 102606465 LOC102606465 http://www.ncbi.nlm.nih.gov/gene/?term=102606465 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000767 102607 Snx19 http://www.ncbi.nlm.nih.gov/gene/?term=102607 "3526401K03Rik, AI195321, AI848208, mKIAA0254 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000768 10260 DENND4A http://www.ncbi.nlm.nih.gov/gene/?term=10260 "IRLB, MYCPBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000769 102614 Rpp25 http://www.ncbi.nlm.nih.gov/gene/?term=102614 AI851155 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000770 10262 SF3B4 http://www.ncbi.nlm.nih.gov/gene/?term=10262 "AFD1, Hsh49, SAP49, SF3b49 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000771 102631772 Gm30025 http://www.ncbi.nlm.nih.gov/gene/?term=102631772 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000772 102631810 Gm30052 http://www.ncbi.nlm.nih.gov/gene/?term=102631810 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000773 102631915 Gm30127 http://www.ncbi.nlm.nih.gov/gene/?term=102631915 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000774 102632457 Gm30524 http://www.ncbi.nlm.nih.gov/gene/?term=102632457 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000775 102632462 Gm30529 http://www.ncbi.nlm.nih.gov/gene/?term=102632462 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000776 102632567 Gm30606 http://www.ncbi.nlm.nih.gov/gene/?term=102632567 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000777 102632947 Gm15731 http://www.ncbi.nlm.nih.gov/gene/?term=102632947 OTTMUSG00000025798 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000778 102632 Acad11 http://www.ncbi.nlm.nih.gov/gene/?term=102632 "5730439E10Rik, AI987948 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000779 102633271 Gm31135 http://www.ncbi.nlm.nih.gov/gene/?term=102633271 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000780 102633311 Gm31169 http://www.ncbi.nlm.nih.gov/gene/?term=102633311 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000781 102633563 Gm31359 http://www.ncbi.nlm.nih.gov/gene/?term=102633563 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000782 102633666 LOC102633666 http://www.ncbi.nlm.nih.gov/gene/?term=102633666 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000783 102633824 Gm13261 http://www.ncbi.nlm.nih.gov/gene/?term=102633824 OTTMUSG00000011193 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000784 102634034 Gm31718 http://www.ncbi.nlm.nih.gov/gene/?term=102634034 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000785 102634543 Gm29128 http://www.ncbi.nlm.nih.gov/gene/?term=102634543 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000786 102634550 Gm27166 http://www.ncbi.nlm.nih.gov/gene/?term=102634550 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000787 102634913 Gm16070 http://www.ncbi.nlm.nih.gov/gene/?term=102634913 OTTMUSG00000029756 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000788 102635567 Gm32865 http://www.ncbi.nlm.nih.gov/gene/?term=102635567 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000789 102635787 Gm33035 http://www.ncbi.nlm.nih.gov/gene/?term=102635787 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000790 102635935 Gm12320 http://www.ncbi.nlm.nih.gov/gene/?term=102635935 OTTMUSG00000006074 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000791 102636202 Gm33337 http://www.ncbi.nlm.nih.gov/gene/?term=102636202 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000792 102636638 Gm13799 http://www.ncbi.nlm.nih.gov/gene/?term=102636638 OTTMUSG00000014516 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000793 102636700 LOC102636700 http://www.ncbi.nlm.nih.gov/gene/?term=102636700 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000794 102638129 Gm11587 http://www.ncbi.nlm.nih.gov/gene/?term=102638129 OTTMUSG00000002370 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000795 102638153 Gm34785 http://www.ncbi.nlm.nih.gov/gene/?term=102638153 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000796 102638523 Gm35066 http://www.ncbi.nlm.nih.gov/gene/?term=102638523 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000797 102638742 Gm35234 http://www.ncbi.nlm.nih.gov/gene/?term=102638742 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000798 102639053 Gm16222 http://www.ncbi.nlm.nih.gov/gene/?term=102639053 OTTMUSG00000031874 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000799 102639404 Gm26839 http://www.ncbi.nlm.nih.gov/gene/?term=102639404 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000800 102639566 Ptgs2os2 http://www.ncbi.nlm.nih.gov/gene/?term=102639566 "Gm26687, Linc-cox2, Lincrna-cox2 " lncRNA Mus musculus 23907535 Cytosol Dendritic cell qRT-PCR hnRNP-A/B and hnRNP-A2/B1 were identified as specific binding partners for lincRNA-Cox2 in both the nuclear and cytosolic fractions. RLID00000801 102639566 Ptgs2os2 http://www.ncbi.nlm.nih.gov/gene/?term=102639566 "Gm26687, Linc-cox2, Lincrna-cox2 " lncRNA Mus musculus 23907535 Nucleus Dendritic cell qRT-PCR hnRNP-A/B and hnRNP-A2/B1 were identified as specific binding partners for lincRNA-Cox2 in both the nuclear and cytosolic fractions. RLID00000802 102639608 Gm16725 http://www.ncbi.nlm.nih.gov/gene/?term=102639608 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000803 10263 CDK2AP2 http://www.ncbi.nlm.nih.gov/gene/?term=10263 "DOC-1R, p14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000804 10263 CDK2AP2 http://www.ncbi.nlm.nih.gov/gene/?term=10263 "DOC-1R, p14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000805 102640287 Gm36394 http://www.ncbi.nlm.nih.gov/gene/?term=102640287 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000806 102640338 Gm26782 http://www.ncbi.nlm.nih.gov/gene/?term=102640338 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000807 102640479 Gm36529 http://www.ncbi.nlm.nih.gov/gene/?term=102640479 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000808 102640577 Gm28515 http://www.ncbi.nlm.nih.gov/gene/?term=102640577 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000809 102640765 Gm36757 http://www.ncbi.nlm.nih.gov/gene/?term=102640765 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000810 102640816 Gm36794 http://www.ncbi.nlm.nih.gov/gene/?term=102640816 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000811 102640900 Gm28231 http://www.ncbi.nlm.nih.gov/gene/?term=102640900 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000812 102641805 LOC102641805 http://www.ncbi.nlm.nih.gov/gene/?term=102641805 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000813 102642321 Gm38604 http://www.ncbi.nlm.nih.gov/gene/?term=102642321 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000814 102642641 LOC102642641 http://www.ncbi.nlm.nih.gov/gene/?term=102642641 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000815 102657 Cd276 http://www.ncbi.nlm.nih.gov/gene/?term=102657 "6030411F23Rik, AU016588, B7RP-2, B7h3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000816 10267 RAMP1 http://www.ncbi.nlm.nih.gov/gene/?term=10267 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000817 10267 RAMP1 http://www.ncbi.nlm.nih.gov/gene/?term=10267 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000818 10269 ZMPSTE24 http://www.ncbi.nlm.nih.gov/gene/?term=10269 "FACE-1, FACE1, HGPS, PRO1, STE24, Ste24p " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000819 10269 ZMPSTE24 http://www.ncbi.nlm.nih.gov/gene/?term=10269 "FACE-1, FACE1, HGPS, PRO1, STE24, Ste24p " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000820 10269 ZMPSTE24 http://www.ncbi.nlm.nih.gov/gene/?term=10269 "FACE-1, FACE1, HGPS, PRO1, STE24, Ste24p " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000821 1026 CDKN1A http://www.ncbi.nlm.nih.gov/gene/?term=1026 "CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000822 1026 CDKN1A http://www.ncbi.nlm.nih.gov/gene/?term=1026 "CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000823 1026 CDKN1A http://www.ncbi.nlm.nih.gov/gene/?term=1026 "CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000824 10270 AKAP8 http://www.ncbi.nlm.nih.gov/gene/?term=10270 "AKAP 95, AKAP-8, AKAP-95, AKAP95 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000825 102724473 GAGE10 http://www.ncbi.nlm.nih.gov/gene/?term=102724473 GAGE-10 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000826 102725100 LOC102725100 http://www.ncbi.nlm.nih.gov/gene/?term=102725100 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000827 10272 FSTL3 http://www.ncbi.nlm.nih.gov/gene/?term=10272 "FLRG, FSRP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000828 10273 STUB1 http://www.ncbi.nlm.nih.gov/gene/?term=10273 "CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000829 10273 STUB1 http://www.ncbi.nlm.nih.gov/gene/?term=10273 "CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000830 10273 STUB1 http://www.ncbi.nlm.nih.gov/gene/?term=10273 "CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000831 10274 STAG1 http://www.ncbi.nlm.nih.gov/gene/?term=10274 "SA1, SCC3A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000832 10274 STAG1 http://www.ncbi.nlm.nih.gov/gene/?term=10274 "SA1, SCC3A " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000833 10276 NET1 http://www.ncbi.nlm.nih.gov/gene/?term=10276 "ARHGEF8, NET1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000834 10276 NET1 http://www.ncbi.nlm.nih.gov/gene/?term=10276 "ARHGEF8A, NET1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000835 10276 NET1 http://www.ncbi.nlm.nih.gov/gene/?term=10276 "ARHGEF8A, NET1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000836 102774 Bbs4 http://www.ncbi.nlm.nih.gov/gene/?term=102774 "AW537059, AW742241, D9Ertd464e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000837 10277 UBE4B http://www.ncbi.nlm.nih.gov/gene/?term=10277 "E4, HDNB1, UBOX3, UFD2, UFD2A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000838 10277 UBE4B http://www.ncbi.nlm.nih.gov/gene/?term=10277 "E4, HDNB1, UBOX3, UFD2, UFD2A " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000839 10277 UBE4B http://www.ncbi.nlm.nih.gov/gene/?term=10277 "E4, HDNB1, UBOX3, UFD2, UFD2A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000840 10279 PRSS16 http://www.ncbi.nlm.nih.gov/gene/?term=10279 TSSP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000841 10279 PRSS16 http://www.ncbi.nlm.nih.gov/gene/?term=10279 TSSP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000842 1027 CDKN1B http://www.ncbi.nlm.nih.gov/gene/?term=1027 "CDKN4, KIP1, MEN1B, MEN4, P27KIP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000843 1027 CDKN1B http://www.ncbi.nlm.nih.gov/gene/?term=1027 "CDKN4, KIP1, MEN1B, MEN4, P27KIP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000844 1027 CDKN1B http://www.ncbi.nlm.nih.gov/gene/?term=1027 "CDKN4, KIP1, MEN1B, MEN4, P27KIP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000845 102800311 TP53COR1 http://www.ncbi.nlm.nih.gov/gene/?term=102800311 "TRP53COR1, linc-p21, lincRNA-p21 " lncRNA Homo sapiens 20673990 Nucleus Lung tumor cell qRT-PCR "To test this, we first performed nuclear fractionation experiments and confirmed that lincRNA-p21 is enriched in the nucleus (Figure S5A). " RLID00000846 102800311 TP53COR1 http://www.ncbi.nlm.nih.gov/gene/?term=102800311 "TRP53COR1, linc-p21, lincRNA-p21 " lncRNA Homo sapiens 22841487 Cytoplasm HeLa cell qRT-PCR LincRNA-p21 was moderately more abundant in the cytoplasm than in the nucleus of fractionated HeLa cells and its levels increased proportionately after silencing HuR (Fig. 2A). RLID00000847 102800311 TP53COR1 http://www.ncbi.nlm.nih.gov/gene/?term=102800311 "TRP53COR1, linc-p21, lincRNA-p21 " lncRNA Homo sapiens 22841487 Nucleus HeLa cell qRT-PCR LincRNA-p21 was moderately more abundant in the cytoplasm than in the nucleus of fractionated HeLa cells and its levels increased proportionately after silencing HuR (Fig. 2A). RLID00000848 10280 SIGMAR1 http://www.ncbi.nlm.nih.gov/gene/?term=10280 "ALS16, DSMA2, OPRS1, SIG-1R, SR-BP, SR-BP1, SRBP, hSigmaR1, sigma1R " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000849 10280 SIGMAR1 http://www.ncbi.nlm.nih.gov/gene/?term=10280 "ALS16, DSMA2, OPRS1, SIG-1R, SR-BP, SR-BP1, SRBP, hSigmaR1, sigma1R " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000850 10281 DSCR4 http://www.ncbi.nlm.nih.gov/gene/?term=10281 "DCRB, DSCRB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000851 10282 BET1 http://www.ncbi.nlm.nih.gov/gene/?term=10282 HBET1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000852 10282 BET1 http://www.ncbi.nlm.nih.gov/gene/?term=10282 HBET1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000853 10282 BET1 http://www.ncbi.nlm.nih.gov/gene/?term=10282 HBET1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000854 10284 SAP18 http://www.ncbi.nlm.nih.gov/gene/?term=10284 "2HOR0202, SAP18P " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000855 10284 SAP18 http://www.ncbi.nlm.nih.gov/gene/?term=10284 "2HOR0202P, SAP18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000856 10285 SMNDC1 http://www.ncbi.nlm.nih.gov/gene/?term=10285 "SMNR, SPF30, TDRD16C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000857 10285 SMNDC1 http://www.ncbi.nlm.nih.gov/gene/?term=10285 "SMNR, SPF30, TDRD16C " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000858 10286 BCAS2 http://www.ncbi.nlm.nih.gov/gene/?term=10286 "DAM1, SPF27, Snt309 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000859 10289 EIF1B http://www.ncbi.nlm.nih.gov/gene/?term=10289 GC20 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000860 10289 EIF1B http://www.ncbi.nlm.nih.gov/gene/?term=10289 GC20 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000861 1028 CDKN1C http://www.ncbi.nlm.nih.gov/gene/?term=1028 "BWCR, BWS, KIP2, WBS, p57, p57Kip2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000862 10291 SF3A1 http://www.ncbi.nlm.nih.gov/gene/?term=10291 "PRP21, PRPF21, SAP114, SF3A120 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000863 10291 SF3A1 http://www.ncbi.nlm.nih.gov/gene/?term=10291 "PRP21, PRPF21, SAP11420, SF3A1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000864 10293 TRAIP http://www.ncbi.nlm.nih.gov/gene/?term=10293 "RNF206, SCKL9, TRIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000865 10293 TRAIP http://www.ncbi.nlm.nih.gov/gene/?term=10293 "RNF206, SCKL9, TRIP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000866 10294 DNAJA2 http://www.ncbi.nlm.nih.gov/gene/?term=10294 "CPR3, DJ3, DJA2, DNAJ, DNJ3, HIRIP4, PRO3015, RDJ2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000867 10294 DNAJA2 http://www.ncbi.nlm.nih.gov/gene/?term=10294 "CPR3, DJ3, DJA2, DNAJ, DNJ3, HIRIP4, PRO3015, RDJ2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000868 10295 BCKDK http://www.ncbi.nlm.nih.gov/gene/?term=10295 "BCKDKD, BDK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000869 10296 MAEA http://www.ncbi.nlm.nih.gov/gene/?term=10296 "EMLP, EMP, GID9, HLC-10, PIG5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000870 10296 MAEA http://www.ncbi.nlm.nih.gov/gene/?term=10296 "EMLP, EMP, GID9, HLC-10, PIG5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000871 10296 MAEA http://www.ncbi.nlm.nih.gov/gene/?term=10296 "EMLP, EMP, GID9, HLC-10, PIG5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000872 10298 PAK4 http://www.ncbi.nlm.nih.gov/gene/?term=10298 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000873 10299 MARCH6 http://www.ncbi.nlm.nih.gov/gene/?term=10299 "DOA10, MARCH-VI, RNF176, TEB4 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000874 1029 CDKN2A http://www.ncbi.nlm.nih.gov/gene/?term=1029 "ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000875 1029 CDKN2A http://www.ncbi.nlm.nih.gov/gene/?term=1029 "ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000876 102 ADAM10 http://www.ncbi.nlm.nih.gov/gene/?term=102 "AD10, AD18, CD156c, HsT18717, MADM, RAK, kuz " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000877 102 ADAM10 http://www.ncbi.nlm.nih.gov/gene/?term=102 "AD10, AD18, CD156c, CDw156, HsT18717, MADM, RAK, kuz " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000878 10300 KATNB1 http://www.ncbi.nlm.nih.gov/gene/?term=10300 "KAT, LIS6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000879 10300 KATNB1 http://www.ncbi.nlm.nih.gov/gene/?term=10300 "KAT, LIS6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000880 10300 KATNB1 http://www.ncbi.nlm.nih.gov/gene/?term=10300 "KAT, LIS6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000881 103012 Firre http://www.ncbi.nlm.nih.gov/gene/?term=103012 "5830467J12Rik, 6720401G13Rik, AW048145 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000882 103012 Firre http://www.ncbi.nlm.nih.gov/gene/?term=103012 "5830467J12Rik, 6720401G13Rik, AW048145 " lncRNA Mus musculus 25887447 Nucleolus Embryo Fluorescence in situ hybridization The X-linked lncRNA Firre helps to position the inactive X chromosome near the nucleolus and to preserve one of its main epigenetic features. The Firre locus on the Xi but not the Xa (active X) was found to be located adjacent to the nucleolus. RLID00000883 10301 DLEU1 http://www.ncbi.nlm.nih.gov/gene/?term=10301 "BCMS, BCMS1, DLB1, DLEU2, LEU1, LEU2, LINC00021, NCRNA00021, XTP6 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000884 10302 SNAPC5 http://www.ncbi.nlm.nih.gov/gene/?term=10302 SNAP19 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000885 10302 SNAPC5 http://www.ncbi.nlm.nih.gov/gene/?term=10302 SNAP19 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000886 10307 APBB3 http://www.ncbi.nlm.nih.gov/gene/?term=10307 "FE65L2, SRA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000887 103080 Sept10 http://www.ncbi.nlm.nih.gov/gene/?term=103080 "4921515A04Rik, 9430099J10Rik, AA408298, AI874685 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000888 103098 Slc6a15 http://www.ncbi.nlm.nih.gov/gene/?term=103098 "AA536730, AI326450, AI326451, v7-3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000889 10309 CCNO http://www.ncbi.nlm.nih.gov/gene/?term=10309 "CCNU, CILD29, UDG2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000890 10311 DSCR3 http://www.ncbi.nlm.nih.gov/gene/?term=10311 "DCRA, DSCRA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000891 10311 DSCR3 http://www.ncbi.nlm.nih.gov/gene/?term=10311 "DCRA, DSCRA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000892 10311 DSCR3 http://www.ncbi.nlm.nih.gov/gene/?term=10311 "DCRA, DSCRA " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000893 10312 TCIRG1 http://www.ncbi.nlm.nih.gov/gene/?term=10312 "ATP6N1C, ATP6V0A3, Atp6i, OC-116kDa, OC116, OPTB1, Stv1, TIRC7, Vph1, a3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000894 103135 Pan2 http://www.ncbi.nlm.nih.gov/gene/?term=103135 "1200014O24Rik, AI047843, AW742773, Usp52, mKIAA0710 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000895 10313 RTN3 http://www.ncbi.nlm.nih.gov/gene/?term=10313 "ASYIP, HAP, NSPL2, NSPLII, RTN3-A1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000896 10313 RTN3 http://www.ncbi.nlm.nih.gov/gene/?term=10313 "ASYIP, HAP, NSPL2, NSPLII-A1, RTN3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000897 10313 RTN3 http://www.ncbi.nlm.nih.gov/gene/?term=10313 "ASYIP, HAP, NSPL2, NSPLII-A1, RTN3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000898 10314 LANCL1 http://www.ncbi.nlm.nih.gov/gene/?term=10314 "GPR69A, p40 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000899 10314 LANCL1 http://www.ncbi.nlm.nih.gov/gene/?term=10314 "GPR69A, p40 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000900 10314 LANCL1 http://www.ncbi.nlm.nih.gov/gene/?term=10314 "GPR69A, p40 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000901 10318 TNIP1 http://www.ncbi.nlm.nih.gov/gene/?term=10318 "ABIN-1, NAF1, VAN, nip40-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000902 1031 CDKN2C http://www.ncbi.nlm.nih.gov/gene/?term=1031 "INK4C, p18, p18-INK4C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000903 1031 CDKN2C http://www.ncbi.nlm.nih.gov/gene/?term=1031 "INK4C, p18, p18-INK4C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000904 1031 CDKN2C http://www.ncbi.nlm.nih.gov/gene/?term=1031 "INK4C, p18, p18-INK4C " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000905 10320 IKZF1 http://www.ncbi.nlm.nih.gov/gene/?term=10320 "Hs.54452, IK1, IKAROS, LYF1, LyF-1, PPP1R92, PRO0758, ZNFN1A1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000906 10321 CRISP3 http://www.ncbi.nlm.nih.gov/gene/?term=10321 "Aeg2, CRISP-3, CRS3, SGP28, dJ442L6.3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000907 10322 SMYD5 http://www.ncbi.nlm.nih.gov/gene/?term=10322 "NN8-4AG, RAI15, RRG1, ZMYND23 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000908 103236 Csnk1g2 http://www.ncbi.nlm.nih.gov/gene/?term=103236 "2810429I12Rik, AI463719 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000909 10325 RRAGB http://www.ncbi.nlm.nih.gov/gene/?term=10325 "RAGB, bA465E19.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000910 10327 AKR1A1 http://www.ncbi.nlm.nih.gov/gene/?term=10327 "ALDR1, ALR, ARM, DD3, HEL-S-6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000911 10328 EMC8 http://www.ncbi.nlm.nih.gov/gene/?term=10328 "C16orf2, C16orf4, COX4NB, FAM158B, NOC4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000912 10328 EMC8 http://www.ncbi.nlm.nih.gov/gene/?term=10328 "C16orf2, C16orf4, COX4NB, FAM158B, NOC4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000913 10328 EMC8 http://www.ncbi.nlm.nih.gov/gene/?term=10328 "C16orf2, C16orf4, COX4NB, FAM158B, NOC4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000914 10329 TMEM5 http://www.ncbi.nlm.nih.gov/gene/?term=10329 "HP10481, MDDGA10 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000915 10329 TMEM5 http://www.ncbi.nlm.nih.gov/gene/?term=10329 "HP10481, MDDGA10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000916 10329 TMEM5 http://www.ncbi.nlm.nih.gov/gene/?term=10329 "HP10481, MDDGA10 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000917 1032 CDKN2D http://www.ncbi.nlm.nih.gov/gene/?term=1032 "INK4D, p19, p19-INK4D " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000918 10330 CNPY2 http://www.ncbi.nlm.nih.gov/gene/?term=10330 "HP10390, MSAP, TMEM4, ZSIG9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000919 10330 CNPY2 http://www.ncbi.nlm.nih.gov/gene/?term=10330 "HP10390, MSAP, TMEM4, ZSIG9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000920 10331 B3GNT3 http://www.ncbi.nlm.nih.gov/gene/?term=10331 "B3GAL-T8, B3GN-T3, B3GNT-3, HP10328, TMEM3, beta3Gn-T3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000921 10335 MRVI1 http://www.ncbi.nlm.nih.gov/gene/?term=10335 "IRAG, JAW1L " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000922 10335 MRVI1 http://www.ncbi.nlm.nih.gov/gene/?term=10335 "IRAG, JAW1L " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000923 10336 PCGF3 http://www.ncbi.nlm.nih.gov/gene/?term=10336 "DONG1, RNF3, RNF3A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000924 1033 CDKN3 http://www.ncbi.nlm.nih.gov/gene/?term=1033 "CDI1, CIP2, KAP, KAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000925 1033 CDKN3 http://www.ncbi.nlm.nih.gov/gene/?term=1033 "CDI1, CIP2, KAP, KAP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000926 1033 CDKN3 http://www.ncbi.nlm.nih.gov/gene/?term=1033 "CDI1, CIP2, KAP, KAP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000927 10342 TFG http://www.ncbi.nlm.nih.gov/gene/?term=10342 "HMSNP, SPG57, TF6, TRKT3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000928 10342 TFG http://www.ncbi.nlm.nih.gov/gene/?term=10342 "HMSNP, SPG57, TF6, TRKT3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000929 10342 TFG http://www.ncbi.nlm.nih.gov/gene/?term=10342 "HMSNP, SPG57, TF6, TRKT3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000930 10345 TRDN http://www.ncbi.nlm.nih.gov/gene/?term=10345 "CPVT5, TDN, TRISK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000931 103468 Nup107 http://www.ncbi.nlm.nih.gov/gene/?term=103468 "AW541137, C76801 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000932 10346 TRIM22 http://www.ncbi.nlm.nih.gov/gene/?term=10346 "GPSTAF50, RNF94, STAF50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000933 10347 ABCA7 http://www.ncbi.nlm.nih.gov/gene/?term=10347 "ABCA-SSN, ABCX " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000934 10347 ABCA7 http://www.ncbi.nlm.nih.gov/gene/?term=10347 "ABCA-SSN, ABCX " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00000935 10347 ABCA7 http://www.ncbi.nlm.nih.gov/gene/?term=10347 "ABCA-SSN, ABCX " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000936 103504742 MT-LIPCAR http://www.ncbi.nlm.nih.gov/gene/?term=103504742 "LIPCAR, uc022bqs.1 " lncRNA Homo sapiens 24663402 Mitochondrion Heart Microarray The mitochondrial long noncoding RNA uc022bqs.1 (LIPCAR) was downregulated early after myocardial infarction but upregulated during later stages. RLID00000937 103514 BB165335 http://www.ncbi.nlm.nih.gov/gene/?term=103514 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000938 10351 ABCA8 http://www.ncbi.nlm.nih.gov/gene/?term=10351 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000939 10352 WARS2 http://www.ncbi.nlm.nih.gov/gene/?term=10352 TrpRS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000940 103551 E130012A19Rik http://www.ncbi.nlm.nih.gov/gene/?term=103551 "AA409164, AI413509, AW539173, E13, esPRC2p48 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000941 103554 Psme4 http://www.ncbi.nlm.nih.gov/gene/?term=103554 "AA409398, AU041366, TEMO, mKIAA0077 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000942 103573 Xpo1 http://www.ncbi.nlm.nih.gov/gene/?term=103573 "AA420417, Crm1, Exp1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000943 103583 Fbxw11 http://www.ncbi.nlm.nih.gov/gene/?term=103583 "2310065A07Rik, AA536858, BTRC2, BTRCP2, Fbxw1b, HOS " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000944 10360 NPM3 http://www.ncbi.nlm.nih.gov/gene/?term=10360 "PORMIN, TMEM123 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000945 103625684 RNU6-2 http://www.ncbi.nlm.nih.gov/gene/?term=103625684 U6-2 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000946 10362 HMG20B http://www.ncbi.nlm.nih.gov/gene/?term=10362 "BRAF25, BRAF35, HMGX2, HMGXB2, PP7706, SMARCE1r, SOXL, pp8857 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000947 10362 HMG20B http://www.ncbi.nlm.nih.gov/gene/?term=10362 "BRAF25, BRAF35, HMGX2, HMGXB2, PP7706, SMARCE1r, SOXL, pp8857 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000948 10363 HMG20A http://www.ncbi.nlm.nih.gov/gene/?term=10363 "HMGX1, HMGXB1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000949 10365 KLF2 http://www.ncbi.nlm.nih.gov/gene/?term=10365 LKLF mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000950 10367 MICU1 http://www.ncbi.nlm.nih.gov/gene/?term=10367 "CALC, CBARA1, EFHA3, MPXPS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000951 10367 MICU1 http://www.ncbi.nlm.nih.gov/gene/?term=10367 "CALC, CBARA1, EFHA3, MPXPS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000952 10370 CITED2 http://www.ncbi.nlm.nih.gov/gene/?term=10370 "ASD8, MRG-1, MRG1, P35SRJ, VSD2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000953 10370 CITED2 http://www.ncbi.nlm.nih.gov/gene/?term=10370 "ASD8, MRG-1, MRG1, P35SRJ, VSD2 " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00000954 103711 Pnpo http://www.ncbi.nlm.nih.gov/gene/?term=103711 AI415282 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000955 10371 SEMA3A http://www.ncbi.nlm.nih.gov/gene/?term=10371 "COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD, coll-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000956 10371 SEMA3A http://www.ncbi.nlm.nih.gov/gene/?term=10371 "COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD, coll-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000957 103724 Tbc1d10a http://www.ncbi.nlm.nih.gov/gene/?term=103724 "AI447804, EPI64, Tbc1d10, mFLJ00288 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000958 103742 Mien1 http://www.ncbi.nlm.nih.gov/gene/?term=103742 "1810046J19Rik, AI463380, Rdx12 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000959 10376 TUBA1B http://www.ncbi.nlm.nih.gov/gene/?term=10376 K-ALPHA-1 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000960 10376 TUBA1B http://www.ncbi.nlm.nih.gov/gene/?term=10376 K-ALPHA-1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000961 103784 Wdr92 http://www.ncbi.nlm.nih.gov/gene/?term=103784 "AI553587, HZGJ " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000962 10379 IRF9 http://www.ncbi.nlm.nih.gov/gene/?term=10379 "IRF-9, ISGF3, ISGF3G, p48 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000963 10380 BPNT1 http://www.ncbi.nlm.nih.gov/gene/?term=10380 "HEL20, PIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000964 10380 BPNT1 http://www.ncbi.nlm.nih.gov/gene/?term=10380 "HEL20, PIP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000965 10380 BPNT1 http://www.ncbi.nlm.nih.gov/gene/?term=10380 "HEL20, PIP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000966 103836 Zfp692 http://www.ncbi.nlm.nih.gov/gene/?term=103836 "AI746306, AI839920-ps, Znf692, Zfp692 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000967 10383 TUBB4B http://www.ncbi.nlm.nih.gov/gene/?term=10383 "Beta2, TUBB2, TUBB2C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000968 10383 TUBB4B http://www.ncbi.nlm.nih.gov/gene/?term=10383 "Beta2, TUBB2, TUBB2C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000969 10384 BTN3A3 http://www.ncbi.nlm.nih.gov/gene/?term=10384 "BTF3, BTN3.3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000970 103850 Nt5m http://www.ncbi.nlm.nih.gov/gene/?term=103850 "2010013E09Rik, AI846937, dNT-2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000971 10385 BTN2A2 http://www.ncbi.nlm.nih.gov/gene/?term=10385 "BT2.2, BTF2, BTN2.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000972 10389 SCML2 http://www.ncbi.nlm.nih.gov/gene/?term=10389 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000973 10389 SCML2 http://www.ncbi.nlm.nih.gov/gene/?term=10389 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00000974 10390 CEPT1 http://www.ncbi.nlm.nih.gov/gene/?term=10390 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000975 10390 CEPT1 http://www.ncbi.nlm.nih.gov/gene/?term=10390 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000976 103910 MYL12B http://www.ncbi.nlm.nih.gov/gene/?term=103910 "MLC-B, MRLC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000977 103910 MYL12B http://www.ncbi.nlm.nih.gov/gene/?term=103910 "MLC-B, MRLC2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000978 10393 ANAPC10 http://www.ncbi.nlm.nih.gov/gene/?term=10393 "APC10, DOC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000979 10395 DLC1 http://www.ncbi.nlm.nih.gov/gene/?term=10395 "ARHGAP7, HP, STARD12, p122-RhoGAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000980 10395 DLC1 http://www.ncbi.nlm.nih.gov/gene/?term=10395 "ARHGAP7, HP, STARD12, p122-RhoGAP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000981 103963 Rpn1 http://www.ncbi.nlm.nih.gov/gene/?term=103963 "AU018702, D6Wsu137e, Rpn-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000982 10396 ATP8A1 http://www.ncbi.nlm.nih.gov/gene/?term=10396 "ATPASEII, ATPIA, ATPP2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000983 10397 NDRG1 http://www.ncbi.nlm.nih.gov/gene/?term=10397 "CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000984 10397 NDRG1 http://www.ncbi.nlm.nih.gov/gene/?term=10397 "CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5 " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00000985 10398 MYL9 http://www.ncbi.nlm.nih.gov/gene/?term=10398 "LC20, MLC-2C, MLC2, MRLC1, MYRL2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000986 10399 RACK1 http://www.ncbi.nlm.nih.gov/gene/?term=10399 "GNB2L1, Gnb2-rs1, H12.3, HLC-7, PIG21 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000987 10399 RACK1 http://www.ncbi.nlm.nih.gov/gene/?term=10399 "GNB2L1, Gnb2-rs1, H12.3, HLC-7, PIG21 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000988 10399 RACK1 http://www.ncbi.nlm.nih.gov/gene/?term=10399 "GNB2L1, Gnb2-rs1, H12.3, HLC-7, PIG21 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000989 1039 CDR2 http://www.ncbi.nlm.nih.gov/gene/?term=1039 "CDR62, Yo " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000990 1039 CDR2 http://www.ncbi.nlm.nih.gov/gene/?term=1039 "CDR62, Yo " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000991 1039 CDR2 http://www.ncbi.nlm.nih.gov/gene/?term=1039 "CDR62, Yo " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000992 103 ADAR http://www.ncbi.nlm.nih.gov/gene/?term=103 "ADAR1, AGS6, DRADA, DSH, DSRAD, G1P1, IFI-4, IFI4, K88DSRBP, P136 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000993 103 ADAR http://www.ncbi.nlm.nih.gov/gene/?term=103 "ADAR1, AGS6, DRADA, DSH, DSRAD, G1P1, IFI-4, IFI4, K88DSRBP, P136 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000994 103 ADAR http://www.ncbi.nlm.nih.gov/gene/?term=103 "ADAR1, AGS6, DRADA, DSH, DSRAD, G1P1, IFI-4, IFI4, K88DSRBP, P136 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00000995 10400 PEMT http://www.ncbi.nlm.nih.gov/gene/?term=10400 "PEAMT, PEMPT, PEMT2, PNMT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00000996 10400 PEMT http://www.ncbi.nlm.nih.gov/gene/?term=10400 "PEAMT, PEMPT2, PNMT, PEMT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00000997 104010 Cdh22 http://www.ncbi.nlm.nih.gov/gene/?term=104010 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00000998 104015 Synj1 http://www.ncbi.nlm.nih.gov/gene/?term=104015 "A930006D20Rik, AA675315, mKIAA0910 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00000999 10402 ST3GAL6 http://www.ncbi.nlm.nih.gov/gene/?term=10402 "SIAT10, ST3GALVI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001000 10403 NDC80 http://www.ncbi.nlm.nih.gov/gene/?term=10403 "HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001001 10404 CPQ http://www.ncbi.nlm.nih.gov/gene/?term=10404 "LDP, PGCP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001002 10406 WFDC2 http://www.ncbi.nlm.nih.gov/gene/?term=10406 "EDDM4, HE4, WAP5, dJ461P17.6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001003 1040 CDS1 http://www.ncbi.nlm.nih.gov/gene/?term=1040 CDS mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001004 1040 CDS1 http://www.ncbi.nlm.nih.gov/gene/?term=1040 CDS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001005 1040 CDS1 http://www.ncbi.nlm.nih.gov/gene/?term=1040 CDS mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001006 104103 Airn http://www.ncbi.nlm.nih.gov/gene/?term=104103 "2810051F02Rik, 2810434M15Rik, AI256653, AI597500, AW049873, Air, B930018I07Rik, D17Ertd663e, IGF2RAS " lncRNA Mus musculus 16874305 Cytoplasm Fibroblast qRT-PCR|Northern blot All Air splice variants are also exported with a similar efficiency as Igf2r (Figure 6D). This indicates that spliced Air in contrast to the majority of unspliced Air can be exported to the cytoplasm. RLID00001007 104103 Airn http://www.ncbi.nlm.nih.gov/gene/?term=104103 "2810051F02Rik, 2810434M15Rik, AI256653, AI597500, AW049873, Air, B930018I07Rik, D17Ertd663e, IGF2RAS " lncRNA Mus musculus 16874305 Nucleus Fibroblast qRT-PCR|Northern blot "We show that Air is transcribed from a DNA methylation-sensitive promoter by RNA polymerase II (RNAPII). However, although it is capped and polyadenylated similar to other RNAPII transcripts, the majority of Air transcripts evade cotranscriptional splicing resulting in a mature 108 kb ncRNA. As a consequence, the mature unspliced Air is nuclear localized and highly unstable. " RLID00001008 104103 Airn http://www.ncbi.nlm.nih.gov/gene/?term=104103 "2810051F02Rik, 2810434M15Rik, AI256653, AI597500, AW049873, Air, B930018I07Rik, D17Ertd663e, IGF2RAS " lncRNA Mus musculus 18988810 Nucleus Placenta In situ hybridization Air is largely unspliced and is retained in the nucleus. Air RNA FISH signals are considerably larger than primary transcript signals for protein-coding genes (Fig. 1A and fig. S2). RLID00001009 104103 Airn http://www.ncbi.nlm.nih.gov/gene/?term=104103 "2810051F02Rik, 2810434M15Rik, AI256653, AI597500, AW049873, Air, B930018I07Rik, D17Ertd663e, IGF2RAS " lncRNA Mus musculus 23239737 Nucleus Placenta In situ hybridization "The nuclear size of the Airn lncRNA product correlates with silencing Slc22a3 in the placenta(9). We used RNA FISH to test whether Airn nuclear size or its subnuclear localization correlates with Igf2r silencing in embryonic cells. Both parameters showed no difference between T51, which silences Igf2r, and T16, which does not (Fig. 3A and fig. S7). " RLID00001010 104103 Airn http://www.ncbi.nlm.nih.gov/gene/?term=104103 "2810051F02Rik, 2810434M15Rik, AI256653, AI597500, AW049873, Air, B930018I07Rik, D17Ertd663e, IGF2RAS " lncRNA Mus musculus 23209567 Nucleus Spleen Next-generation sequencing|qRT-PCR "Furthermore, we found the Air long non-coding RNA almost exclusively in the nuclear fraction in agreement with the finding that Air RNA is retained in the nucleus. " RLID00001011 104103 Airn http://www.ncbi.nlm.nih.gov/gene/?term=104103 "2810051F02Rik, 2810434M15Rik, AI256653, AI597500, AW049873, Air, B930018I07Rik, D17Ertd663e, IGF2RAS " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001012 10410 IFITM3 http://www.ncbi.nlm.nih.gov/gene/?term=10410 "1-8U, DSPA2b, IP15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001013 10412 NSA2 http://www.ncbi.nlm.nih.gov/gene/?term=10412 "CDK105, HCL-G1, HCLG1, HUSSY-29, HUSSY29, TINP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001014 10412 NSA2 http://www.ncbi.nlm.nih.gov/gene/?term=10412 "CDK105, HCL-G1, HCLG1, HUSSY-29, HUSSY29, TINP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001015 10413 YAP1 http://www.ncbi.nlm.nih.gov/gene/?term=10413 "COB1, YAP, YAP2, YAP65, YKI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001016 104175 Sbk1 http://www.ncbi.nlm.nih.gov/gene/?term=104175 Sbk mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001017 104184 Blmh http://www.ncbi.nlm.nih.gov/gene/?term=104184 "AI035728, Bh, Bmh " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001018 10419 PRMT5 http://www.ncbi.nlm.nih.gov/gene/?term=10419 "HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001019 10419 PRMT5 http://www.ncbi.nlm.nih.gov/gene/?term=10419 "HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001020 10421 CD2BP2 http://www.ncbi.nlm.nih.gov/gene/?term=10421 "FWP010, LIN1, PPP1R59, Snu40, U5-52K " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001021 10423 CDIPT http://www.ncbi.nlm.nih.gov/gene/?term=10423 "PIS, PIS1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001022 10423 CDIPT http://www.ncbi.nlm.nih.gov/gene/?term=10423 "PIS, PIS1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001023 10423 CDIPT http://www.ncbi.nlm.nih.gov/gene/?term=10423 "PIS, PIS1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001024 10424 PGRMC2 http://www.ncbi.nlm.nih.gov/gene/?term=10424 "DG6, PMBP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001025 104252 Cdc42ep2 http://www.ncbi.nlm.nih.gov/gene/?term=104252 "1110008C05Rik, Borg1, Cep2, D19Bwg1013e " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001026 10425 ARIH2 http://www.ncbi.nlm.nih.gov/gene/?term=10425 "ARI2, TRIAD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001027 10425 ARIH2 http://www.ncbi.nlm.nih.gov/gene/?term=10425 "ARI2, TRIAD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001028 104263 Kdm3a http://www.ncbi.nlm.nih.gov/gene/?term=104263 "1700105C21Rik, C230043E16Rik, JHDM2a, Jmjd1, Jmjd1a, KDM2A, TGSA, Tsga " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001029 10426 TUBGCP3 http://www.ncbi.nlm.nih.gov/gene/?term=10426 "104p, GCP3, Grip104, SPBC98, Spc98, Spc98p " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001030 10426 TUBGCP3 http://www.ncbi.nlm.nih.gov/gene/?term=10426 "104p, GCP3, Grip104, SPBC98, Spc98, Spc98p " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001031 10426 TUBGCP3 http://www.ncbi.nlm.nih.gov/gene/?term=10426 "104p, GCP3, Grip104, SPBC98, Spc98, Spc98p " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001032 10426 TUBGCP3 http://www.ncbi.nlm.nih.gov/gene/?term=10426 "104p, GCP3, Grip104, SPBC98, Spc98, Spc98p " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001033 10426 TUBGCP3 http://www.ncbi.nlm.nih.gov/gene/?term=10426 "104p, GCP3, Grip104, SPBC98, Spc98, Spc98p " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001034 10427 SEC24B http://www.ncbi.nlm.nih.gov/gene/?term=10427 SEC24 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001035 10428 CFDP1 http://www.ncbi.nlm.nih.gov/gene/?term=10428 "BCNT, BUCENTAUR, CENP-29, CP27, SWC5, Yeti, p97 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001036 10428 CFDP1 http://www.ncbi.nlm.nih.gov/gene/?term=10428 "BCNT, BUCENTAUR, CENP-29, CP27, SWC5, Yeti, p97 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001037 10430 TMEM147 http://www.ncbi.nlm.nih.gov/gene/?term=10430 NIFIE14 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001038 10430 TMEM147 http://www.ncbi.nlm.nih.gov/gene/?term=10430 NIFIE14 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001039 10432 RBM14 http://www.ncbi.nlm.nih.gov/gene/?term=10432 "COAA, PSP2, SIP, SYTIP1, TMEM137 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001040 10432 RBM14 http://www.ncbi.nlm.nih.gov/gene/?term=10432 "COAA, PSP2, SIP, SYTIP1, TMEM137 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001041 10432 RBM14 http://www.ncbi.nlm.nih.gov/gene/?term=10432 "COAA, PSP2, SIP, SYTIP1, TMEM137 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001042 104355148 CYP4A22-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=104355148 ncRNA-a3 lncRNA Homo sapiens 25332394 Nucleus - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/cyp4a22-as1/ RLID00001043 104355148 CYP4A22-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=104355148 ncRNA-a3 lncRNA Homo sapiens 22955988 Nucleus Brain Microarray "We examined the subcellular location of a number of well-known lncRNAs (Fig. 8D). Unsurprisingly, the X-chromosome inactivating transcript XIST was extremely highly enriched in the nucleus for all cells we examined (with a maximum enrichment of 273-fold in the nucleus of GM12878 cells) (Fig. 8D). Other regulatory lncRNAs such as GAS5, LINC00568 (also known as ncRNA-a1), CYP4A22-AS1 (also known as ncRNA-a3), MIAT, and MEG3 were nuclear enriched in at least two different cell types, consistent with their reported roles in gene regulation. Other transcripts, including the bifunctional transcript SRA1, which acts as both a regulatory RNA and a protein-coding sequence, have more variable subcellular location depending on cell type. As reported previously, the H19 transcript is consistently enriched in the cytoplasm, especially when comparing with the chromatin fraction (cytoplasmic/chromatin enrichment 167-fold). " RLID00001044 10435 CDC42EP2 http://www.ncbi.nlm.nih.gov/gene/?term=10435 "BORG1, CEP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001045 104362 Meig1 http://www.ncbi.nlm.nih.gov/gene/?term=104362 "MLZ-278, Meg1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001046 10436 EMG1 http://www.ncbi.nlm.nih.gov/gene/?term=10436 "C2F, Grcc2f, NEP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001047 10437 IFI30 http://www.ncbi.nlm.nih.gov/gene/?term=10437 "GILT, IFI-30, IP-30, IP30 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001048 104382 Barhl2 http://www.ncbi.nlm.nih.gov/gene/?term=104382 "E130309B19Rik, MBH1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001049 10438 C1D http://www.ncbi.nlm.nih.gov/gene/?term=10438 "LRP1, Rrp47, SUN-CoR, SUNCOR, hC1D " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001050 10439 OLFM1 http://www.ncbi.nlm.nih.gov/gene/?term=10439 "AMY, NOE1, NOELIN1, OlfA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001051 10440 TIMM17A http://www.ncbi.nlm.nih.gov/gene/?term=10440 "TIM17, TIM17A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001052 10440 TIMM17A http://www.ncbi.nlm.nih.gov/gene/?term=10440 "TIM17, TIM17A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001053 10443 N4BP2L2 http://www.ncbi.nlm.nih.gov/gene/?term=10443 "92M18.3, CG005, PFAAP5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001054 10443 N4BP2L2 http://www.ncbi.nlm.nih.gov/gene/?term=10443 "92M18.3, CG005, CG016, PFAAP5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001055 104445 Cdc42ep1 http://www.ncbi.nlm.nih.gov/gene/?term=104445 "1810058K22Rik, AA980734, Borg5, CEP1, MSE55 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001056 10444 ZER1 http://www.ncbi.nlm.nih.gov/gene/?term=10444 "C9orf60, ZYG, ZYG11BL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001057 10444 ZER1 http://www.ncbi.nlm.nih.gov/gene/?term=10444 "C9orf60, ZYG, ZYG11BL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001058 104457 0610010K14Rik http://www.ncbi.nlm.nih.gov/gene/?term=104457 "1110020A23Rik, AL033328, AU045833, Bap18 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001059 104458 Rars http://www.ncbi.nlm.nih.gov/gene/?term=104458 "2610011N19Rik, 2610037E21Rik, AL033339, AW985894 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001060 10445 MCRS1 http://www.ncbi.nlm.nih.gov/gene/?term=10445 "ICP22BP, INO80Q, MCRS2, MSP58, P78 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001061 10445 MCRS1 http://www.ncbi.nlm.nih.gov/gene/?term=10445 "ICP22BP, INO80Q, MCRS2, MSP58, P78 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001062 10445 MCRS1 http://www.ncbi.nlm.nih.gov/gene/?term=10445 "ICP22BP, INO80Q, MCRS2, MSP58, P78 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001063 104472717 LINC01224 http://www.ncbi.nlm.nih.gov/gene/?term=104472717 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001064 104479 Ccdc117 http://www.ncbi.nlm.nih.gov/gene/?term=104479 "1110004K02Rik, 1700026O03Rik, AU018638, AU042822, AV173073, BC018601 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001065 10447 FAM3C http://www.ncbi.nlm.nih.gov/gene/?term=10447 "GS3786, ILEI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001066 10447 FAM3C http://www.ncbi.nlm.nih.gov/gene/?term=10447 "GS3786, ILEI " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001067 10449 ACAA2 http://www.ncbi.nlm.nih.gov/gene/?term=10449 DSAEC mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001068 1044 CDX1 http://www.ncbi.nlm.nih.gov/gene/?term=1044 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001069 10450 PPIE http://www.ncbi.nlm.nih.gov/gene/?term=10450 "CYP-33, CYP33 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001070 10451 VAV3 http://www.ncbi.nlm.nih.gov/gene/?term=10451 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001071 10452 TOMM40 http://www.ncbi.nlm.nih.gov/gene/?term=10452 "C19orf1, D19S1177E, PER-EC1, PEREC1, TOM40 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001072 10452 TOMM40 http://www.ncbi.nlm.nih.gov/gene/?term=10452 "C19orf1, D19S1177E, PER-EC1, PEREC1, TOM40 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001073 10454 TAB1 http://www.ncbi.nlm.nih.gov/gene/?term=10454 "3'-Tab1, MAP3K7IP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001074 10454 TAB1 http://www.ncbi.nlm.nih.gov/gene/?term=10454 "3'-Tab1, MAP3K7IP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001075 10455 ECI2 http://www.ncbi.nlm.nih.gov/gene/?term=10455 "ACBD2, DRS-1, DRS1, HCA88, PECI, dJ1013A10.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001076 10456 HAX1 http://www.ncbi.nlm.nih.gov/gene/?term=10456 "HCLSBP1, HS1BP1, SCN3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001077 10456 HAX1 http://www.ncbi.nlm.nih.gov/gene/?term=10456 "HCLSBP1, HS1BP1, SCN3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001078 104570 Smek2 http://www.ncbi.nlm.nih.gov/gene/?term=104570 "AW011752, AW557776, Ppp4r3b, mKIAA1387 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001079 10457 GPNMB http://www.ncbi.nlm.nih.gov/gene/?term=10457 "HGFIN, NMB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001080 10458 BAIAP2 http://www.ncbi.nlm.nih.gov/gene/?term=10458 "BAP2, FLAF3, IRSP53 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001081 10459 MAD2L2 http://www.ncbi.nlm.nih.gov/gene/?term=10459 "MAD2B, POLZ2, REV7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001082 1045 CDX2 http://www.ncbi.nlm.nih.gov/gene/?term=1045 "CDX-3, CDX2/AS, CDX3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001083 1045 CDX2 http://www.ncbi.nlm.nih.gov/gene/?term=1045 "CDX-3/AS, CDX3, CDX2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001084 10460 TACC3 http://www.ncbi.nlm.nih.gov/gene/?term=10460 "ERIC-1, ERIC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001085 10460 TACC3 http://www.ncbi.nlm.nih.gov/gene/?term=10460 "ERIC-1, ERIC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001086 10460 TACC3 http://www.ncbi.nlm.nih.gov/gene/?term=10460 "ERIC-1, ERIC1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001087 10461 MERTK http://www.ncbi.nlm.nih.gov/gene/?term=10461 "MER, RP38, Tyro12, c-Eyk, c-mer " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001088 10461 MERTK http://www.ncbi.nlm.nih.gov/gene/?term=10461 "MER, RP38, Tyro12, c-Eyk, c-mer " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001089 104625 Cnot6 http://www.ncbi.nlm.nih.gov/gene/?term=104625 CCR4 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001090 10463 SLC30A9 http://www.ncbi.nlm.nih.gov/gene/?term=10463 "C4orf1, GAC63, HUEL, ZNT9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001091 10463 SLC30A9 http://www.ncbi.nlm.nih.gov/gene/?term=10463 "C4orf1, GAC63, HUEL, ZNT9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001092 10465 PPIH http://www.ncbi.nlm.nih.gov/gene/?term=10465 "CYP-20, CYPH, SnuCyp-20, USA-CYP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001093 10465 PPIH http://www.ncbi.nlm.nih.gov/gene/?term=10465 "CYP-20, CYPH, SnuCyp-20, USA-CYP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001094 10465 PPIH http://www.ncbi.nlm.nih.gov/gene/?term=10465 "CYP-20, CYPH, SnuCyp-20, USA-CYP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001095 104662 Tsr1 http://www.ncbi.nlm.nih.gov/gene/?term=104662 "AU040765, AW550801, mKIAA1401 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001096 10467 ZNHIT1 http://www.ncbi.nlm.nih.gov/gene/?term=10467 "CG1I, ZNFN4A1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001097 10467 ZNHIT1 http://www.ncbi.nlm.nih.gov/gene/?term=10467 "CG1I, ZNFN4A1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001098 104681 Slc16a6 http://www.ncbi.nlm.nih.gov/gene/?term=104681 "AW743111, ESTM12, MCT 6, MCT 7, MCT6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001099 10469 TIMM44 http://www.ncbi.nlm.nih.gov/gene/?term=10469 TIM44 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001100 10471 PFDN6 http://www.ncbi.nlm.nih.gov/gene/?term=10471 "H2-KE2, HKE2, KE-2, PFD6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001101 10471 PFDN6 http://www.ncbi.nlm.nih.gov/gene/?term=10471 "H2-KE2, HKE2, KE-2, PFD6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001102 104721 Ddx1 http://www.ncbi.nlm.nih.gov/gene/?term=104721 "AA409185, DBP-RB " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001103 10472 ZBTB18 http://www.ncbi.nlm.nih.gov/gene/?term=10472 "C2H2-171, MRD22, RP58, TAZ-1, ZNF238 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001104 10473 HMGN4 http://www.ncbi.nlm.nih.gov/gene/?term=10473 "HMG17L3, NHC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001105 10473 HMGN4 http://www.ncbi.nlm.nih.gov/gene/?term=10473 "HMG17L3, NHC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001106 10474 TADA3 http://www.ncbi.nlm.nih.gov/gene/?term=10474 "ADA3, NGG1, STAF54, TADA3L, hADA3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001107 10474 TADA3 http://www.ncbi.nlm.nih.gov/gene/?term=10474 "ADA3, NGG1, STAF54L, hADA3, TADA3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001108 10474 TADA3 http://www.ncbi.nlm.nih.gov/gene/?term=10474 "ADA3, NGG1, STAF54L, hADA3, TADA3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001109 10475 TRIM38 http://www.ncbi.nlm.nih.gov/gene/?term=10475 "RNF15, RORET " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001110 10476 ATP5H http://www.ncbi.nlm.nih.gov/gene/?term=10476 ATPQ mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001111 104771 Jkamp http://www.ncbi.nlm.nih.gov/gene/?term=104771 "1200003C05Rik, 2310047L11Rik, Jamp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001112 104771 Jkamp http://www.ncbi.nlm.nih.gov/gene/?term=104771 "1200003C05Rik, 2310047L11Rik, Jamp " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001113 104776 Aldh6a1 http://www.ncbi.nlm.nih.gov/gene/?term=104776 "1110038I05Rik, Mmsdh " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001114 10477 UBE2E3 http://www.ncbi.nlm.nih.gov/gene/?term=10477 "UBCH9, UbcM2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001115 10477 UBE2E3 http://www.ncbi.nlm.nih.gov/gene/?term=10477 "UBCH9, UbcM2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001116 10477 UBE2E3 http://www.ncbi.nlm.nih.gov/gene/?term=10477 "UBCH9, UbcM2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001117 10478 SLC25A17 http://www.ncbi.nlm.nih.gov/gene/?term=10478 PMP34 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001118 10478 SLC25A17 http://www.ncbi.nlm.nih.gov/gene/?term=10478 PMP34 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001119 104799 Vipas39 http://www.ncbi.nlm.nih.gov/gene/?term=104799 "6720456H09Rik, 9330175H22Rik, AI413782, SPE-39, Spe39, Vipar, hSPE-39 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001120 10479 SLC9A6 http://www.ncbi.nlm.nih.gov/gene/?term=10479 "MRSA, NHE6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001121 10479 SLC9A6 http://www.ncbi.nlm.nih.gov/gene/?term=10479 "MRSA, NHE6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001122 10479 SLC9A6 http://www.ncbi.nlm.nih.gov/gene/?term=10479 "MRSA, NHE6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001123 1047 CLGN http://www.ncbi.nlm.nih.gov/gene/?term=1047 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001124 1047 CLGN http://www.ncbi.nlm.nih.gov/gene/?term=1047 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001125 104806 Fancm http://www.ncbi.nlm.nih.gov/gene/?term=104806 "AI427100, C730036B14Rik, D12Ertd364e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001126 10480 EIF3M http://www.ncbi.nlm.nih.gov/gene/?term=10480 "B5, GA17, PCID1, TANGO7, hfl-B5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001127 10480 EIF3M http://www.ncbi.nlm.nih.gov/gene/?term=10480 "B5, GA17, PCID1, TANGO7, hfl-B5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001128 10480 EIF3M http://www.ncbi.nlm.nih.gov/gene/?term=10480 "B5, GA17, PCID1, TANGO7, hfl-B5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001129 10481 HOXB13 http://www.ncbi.nlm.nih.gov/gene/?term=10481 PSGD mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001130 10482 NXF1 http://www.ncbi.nlm.nih.gov/gene/?term=10482 "MEX67, TAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001131 10482 NXF1 http://www.ncbi.nlm.nih.gov/gene/?term=10482 "MEX67, TAP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001132 104836 Cbll1 http://www.ncbi.nlm.nih.gov/gene/?term=104836 "AI467391, Hakai, c-Cbl-like " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001133 10483 SEC23B http://www.ncbi.nlm.nih.gov/gene/?term=10483 "CDA-II, CDAII, CDAN2, HEMPAS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001134 10483 SEC23B http://www.ncbi.nlm.nih.gov/gene/?term=10483 "CDA-II, CDAII, CDAN2, CWS7, HEMPAS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001135 10484 SEC23A http://www.ncbi.nlm.nih.gov/gene/?term=10484 CLSD mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001136 10484 SEC23A http://www.ncbi.nlm.nih.gov/gene/?term=10484 CLSD mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001137 10485 C1orf61 http://www.ncbi.nlm.nih.gov/gene/?term=10485 CROC4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001138 10487 CAP1 http://www.ncbi.nlm.nih.gov/gene/?term=10487 "CAP-PEN, CAP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001139 104885 Tmem179 http://www.ncbi.nlm.nih.gov/gene/?term=104885 AI839735 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001140 104886 Rab15 http://www.ncbi.nlm.nih.gov/gene/?term=104886 "2310012G06Rik, AI840042 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001141 10488 CREB3 http://www.ncbi.nlm.nih.gov/gene/?term=10488 "LUMAN, LZIP, sLZIP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001142 10488 CREB3 http://www.ncbi.nlm.nih.gov/gene/?term=10488 "LUMAN, LZIP, sLZIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001143 10488 CREB3 http://www.ncbi.nlm.nih.gov/gene/?term=10488 "LUMAN, LZIP, sLZIP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001144 10489 LRRC41 http://www.ncbi.nlm.nih.gov/gene/?term=10489 "MUF1, PP7759 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001145 10489 LRRC41 http://www.ncbi.nlm.nih.gov/gene/?term=10489 "MUF1, PP7759 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001146 1048 CEACAM5 http://www.ncbi.nlm.nih.gov/gene/?term=1048 "CD66e, CEA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001147 10490 VTI1B http://www.ncbi.nlm.nih.gov/gene/?term=10490 "VTI1, VTI1-LIKE, VTI1L, VTI2, v-SNARE, vti1-rp1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001148 10491 CRTAP http://www.ncbi.nlm.nih.gov/gene/?term=10491 "CASP, LEPREL3, OI7, P3H5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001149 10491 CRTAP http://www.ncbi.nlm.nih.gov/gene/?term=10491 "CASP, LEPREL3, OI7, P3H5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001150 10491 CRTAP http://www.ncbi.nlm.nih.gov/gene/?term=10491 "CASP, LEPREL3, OI7, P3H5 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001151 10492 SYNCRIP http://www.ncbi.nlm.nih.gov/gene/?term=10492 "GRY-RBP, GRYRBP, HNRNPQ, HNRPQ1, NSAP1, PP68, hnRNP-Q " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001152 10492 SYNCRIP http://www.ncbi.nlm.nih.gov/gene/?term=10492 "GRY-RBP, GRYRBP, HNRNPQ, HNRPQ1, NSAP1, PP68, hnRNP-Q " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001153 10492 SYNCRIP http://www.ncbi.nlm.nih.gov/gene/?term=10492 "GRY-RBP, GRYRBP, HNRNPQ, HNRPQ1, NSAP1, PP68, hnRNP-Q " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001154 10493 VAT1 http://www.ncbi.nlm.nih.gov/gene/?term=10493 VATI mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001155 10493 VAT1 http://www.ncbi.nlm.nih.gov/gene/?term=10493 VATI mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001156 10495 ENOX2 http://www.ncbi.nlm.nih.gov/gene/?term=10495 "APK1, COVA1, tNOX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001157 10495 ENOX2 http://www.ncbi.nlm.nih.gov/gene/?term=10495 "APK1, COVA1, tNOX " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001158 10497 UNC13B http://www.ncbi.nlm.nih.gov/gene/?term=10497 "MUNC13, UNC13, Unc13h2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001159 10497 UNC13B http://www.ncbi.nlm.nih.gov/gene/?term=10497 "MUNC13, UNC13, Unc13h2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001160 10497 UNC13B http://www.ncbi.nlm.nih.gov/gene/?term=10497 "MUNC13, UNC13, Unc13h2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001161 10498 CARM1 http://www.ncbi.nlm.nih.gov/gene/?term=10498 PRMT4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001162 10499 NCOA2 http://www.ncbi.nlm.nih.gov/gene/?term=10499 "GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001163 104 ADARB1 http://www.ncbi.nlm.nih.gov/gene/?term=104 "ADAR2, DRABA2, DRADA2, RED1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001164 104 ADARB1 http://www.ncbi.nlm.nih.gov/gene/?term=104 "ADAR2, DRABA2, DRADA2, RED1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001165 105000 Dnal1 http://www.ncbi.nlm.nih.gov/gene/?term=105000 "1700010H15Rik, AW121714, Dnalc1, E330027P08Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001166 10500 SEMA6C http://www.ncbi.nlm.nih.gov/gene/?term=10500 "SEMAY, m-SemaY, m-SemaY2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001167 10507 SEMA4D http://www.ncbi.nlm.nih.gov/gene/?term=10507 "C9orf164, CD100, M-sema-G, SEMAJ, coll-4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001168 10512 SEMA3C http://www.ncbi.nlm.nih.gov/gene/?term=10512 "SEMAE, SemE " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001169 10513 APPBP2 http://www.ncbi.nlm.nih.gov/gene/?term=10513 "APP-BP2, HS.84084, PAT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001170 10513 APPBP2 http://www.ncbi.nlm.nih.gov/gene/?term=10513 "APP-BP2, HS.84084, PAT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001171 10513 APPBP2 http://www.ncbi.nlm.nih.gov/gene/?term=10513 "APP-BP2, HS.84084, PAT1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001172 10514 MYBBP1A http://www.ncbi.nlm.nih.gov/gene/?term=10514 "P160, PAP2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001173 10517 FBXW10 http://www.ncbi.nlm.nih.gov/gene/?term=10517 "Fbw10, HREP, SM25H2, SM2SH2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001174 10517 FBXW10 http://www.ncbi.nlm.nih.gov/gene/?term=10517 "Fbw10, HREP, SM25H2, SM2SH2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001175 10518 CIB2 http://www.ncbi.nlm.nih.gov/gene/?term=10518 "DFNB48, KIP2, USH1J " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001176 105193 Nhlrc1 http://www.ncbi.nlm.nih.gov/gene/?term=105193 "AI505271, B230309E09Rik, EPM2B " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001177 10519 CIB1 http://www.ncbi.nlm.nih.gov/gene/?term=10519 "CIB, CIBP, KIP1, PRKDCIP, SIP2-28 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001178 10519 CIB1 http://www.ncbi.nlm.nih.gov/gene/?term=10519 "CIB, CIBP, KIP1, PRKDCIP, SIP2-28 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001179 10519 CIB1 http://www.ncbi.nlm.nih.gov/gene/?term=10519 "CIB, CIBP, KIP1, PRKDCIP, SIP2-28 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001180 1051 CEBPB http://www.ncbi.nlm.nih.gov/gene/?term=1051 "C/EBP-beta, IL6DBP, NF-IL6, TCF5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001181 105203 Fam208b http://www.ncbi.nlm.nih.gov/gene/?term=105203 "AI645998, Pap20, mKIAA2006 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001182 10521 DDX17 http://www.ncbi.nlm.nih.gov/gene/?term=10521 "P72, RH70 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001183 10521 DDX17 http://www.ncbi.nlm.nih.gov/gene/?term=10521 "P72, RH70 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001184 10522 DEAF1 http://www.ncbi.nlm.nih.gov/gene/?term=10522 "MRD24, NUDR, SPN, ZMYND5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001185 10522 DEAF1 http://www.ncbi.nlm.nih.gov/gene/?term=10522 "MRD24, NUDR, SPN, ZMYND5 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001186 10523 CHERP http://www.ncbi.nlm.nih.gov/gene/?term=10523 "DAN16, SCAF6, SRA1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001187 105243045 Gm15774 http://www.ncbi.nlm.nih.gov/gene/?term=105243045 OTTMUSG00000026125 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001188 105243395 Gm39329 http://www.ncbi.nlm.nih.gov/gene/?term=105243395 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001189 105243704 Gm39526 http://www.ncbi.nlm.nih.gov/gene/?term=105243704 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001190 105243929 Gm39644 http://www.ncbi.nlm.nih.gov/gene/?term=105243929 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001191 105245179 Gm20513 http://www.ncbi.nlm.nih.gov/gene/?term=105245179 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001192 105245 Txndc5 http://www.ncbi.nlm.nih.gov/gene/?term=105245 "AL022641, ERp46, PC-TRP " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001193 105246095 Gm26562 http://www.ncbi.nlm.nih.gov/gene/?term=105246095 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001194 105246278 B230354K17Rik http://www.ncbi.nlm.nih.gov/gene/?term=105246278 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001195 10524 KAT5 http://www.ncbi.nlm.nih.gov/gene/?term=10524 "ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, ZC2HC5, cPLA2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001196 10524 KAT5 http://www.ncbi.nlm.nih.gov/gene/?term=10524 "ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, ZC2HC5, cPLA2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001197 10525 HYOU1 http://www.ncbi.nlm.nih.gov/gene/?term=10525 "GRP-170, Grp170, HSP12A, ORP-150, ORP150 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001198 10526 IPO8 http://www.ncbi.nlm.nih.gov/gene/?term=10526 RANBP8 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001199 10526 IPO8 http://www.ncbi.nlm.nih.gov/gene/?term=10526 RANBP8 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001200 10526 IPO8 http://www.ncbi.nlm.nih.gov/gene/?term=10526 RANBP8 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001201 105278 Cdk20 http://www.ncbi.nlm.nih.gov/gene/?term=105278 "4932702G04Rik, AU019450, AW558027, CDCH, Ccrk, PNQLARE, p42 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001202 10527 IPO7 http://www.ncbi.nlm.nih.gov/gene/?term=10527 "Imp7, RANBP7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001203 10527 IPO7 http://www.ncbi.nlm.nih.gov/gene/?term=10527 "Imp7, RANBP7 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001204 10527 IPO7 http://www.ncbi.nlm.nih.gov/gene/?term=10527 "Imp7, RANBP7 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001205 10528 NOP56 http://www.ncbi.nlm.nih.gov/gene/?term=10528 "NOL5A, SCA36 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001206 10528 NOP56 http://www.ncbi.nlm.nih.gov/gene/?term=10528 "NOL5A, SCA36 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001207 10529 NEBL http://www.ncbi.nlm.nih.gov/gene/?term=10529 "LASP2, LNEBL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001208 1052 CEBPD http://www.ncbi.nlm.nih.gov/gene/?term=1052 "C/EBP-delta, CELF, CRP3, NF-IL6-beta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001209 10531 PITRM1 http://www.ncbi.nlm.nih.gov/gene/?term=10531 "MP1, PreP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001210 10531 PITRM1 http://www.ncbi.nlm.nih.gov/gene/?term=10531 "MP1, PreP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001211 10533 ATG7 http://www.ncbi.nlm.nih.gov/gene/?term=10533 "APG7-LIKE, APG7L, GSA7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001212 105348 Golm1 http://www.ncbi.nlm.nih.gov/gene/?term=105348 "2310001L02Rik, AW125446, D030064E01Rik, GP73, Golph2, PSEC0257 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001213 10534 SSSCA1 http://www.ncbi.nlm.nih.gov/gene/?term=10534 p27 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001214 10534 SSSCA1 http://www.ncbi.nlm.nih.gov/gene/?term=10534 p27 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001215 105351 AW209491 http://www.ncbi.nlm.nih.gov/gene/?term=105351 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001216 10535 RNASEH2A http://www.ncbi.nlm.nih.gov/gene/?term=10535 "AGS4, JUNB, RNASEHI, RNHIA, RNHL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001217 105370541 LOC105370541 http://www.ncbi.nlm.nih.gov/gene/?term=105370541 lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00001218 105377 Slf1 http://www.ncbi.nlm.nih.gov/gene/?term=105377 "2700017A04Rik, AW545819, Ankrd32, Brctd1, Brctx, C730024G01Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001219 10539 GLRX3 http://www.ncbi.nlm.nih.gov/gene/?term=10539 "GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001220 10539 GLRX3 http://www.ncbi.nlm.nih.gov/gene/?term=10539 "GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001221 10539 GLRX3 http://www.ncbi.nlm.nih.gov/gene/?term=10539 "GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001222 10540 DCTN2 http://www.ncbi.nlm.nih.gov/gene/?term=10540 "DCTN50, DYNAMITIN, HEL-S-77, RBP50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001223 10540 DCTN2 http://www.ncbi.nlm.nih.gov/gene/?term=10540 "DCTN50, DYNAMITIN, HEL-S-77, RBP50 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001224 10540 DCTN2 http://www.ncbi.nlm.nih.gov/gene/?term=10540 "DCTN50, DYNAMITIN, HEL-S-77, RBP50 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001225 10541 ANP32B http://www.ncbi.nlm.nih.gov/gene/?term=10541 "APRIL, PHAPI2, SSP29 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001226 10541 ANP32B http://www.ncbi.nlm.nih.gov/gene/?term=10541 "APRIL, PHAPI2, SSP29 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001227 10542 LAMTOR5 http://www.ncbi.nlm.nih.gov/gene/?term=10542 "HBXIP, XIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001228 105440 Kctd9 http://www.ncbi.nlm.nih.gov/gene/?term=105440 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001229 105445 Dock9 http://www.ncbi.nlm.nih.gov/gene/?term=105445 "AA959601, AW538057, B230309H04Rik, D14Wsu89e, Zizimin1, mKIAA1058 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001230 10544 PROCR http://www.ncbi.nlm.nih.gov/gene/?term=10544 "CCCA, CCD41, EPCR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001231 10544 PROCR http://www.ncbi.nlm.nih.gov/gene/?term=10544 "CCCA, CCD41, EPCR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001232 105463124 Borg http://www.ncbi.nlm.nih.gov/gene/?term=105463124 lncRNA Mus musculus 24732794 Nucleus Breast cancer cell RT-PCR|In situ hybridization "As many lncRNAs regulate nuclear events and thus must localize to nuclei, we analyzed the sequence requirements for nuclear localization in an intergenic lncRNA named BORG (BMP2-OP1-responsive gene), which is both spliced and polyadenylated but is strictly localized in nuclei. " RLID00001233 10548 TM9SF1 http://www.ncbi.nlm.nih.gov/gene/?term=10548 "HMP70, MP70 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001234 10549 PRDX4 http://www.ncbi.nlm.nih.gov/gene/?term=10549 "AOE37-2, AOE372, HEL-S-97n, PRX-4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001235 10549 PRDX4 http://www.ncbi.nlm.nih.gov/gene/?term=10549 "AOE37-2, AOE372, HEL-S-97n, PRX-4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001236 10549 PRDX4 http://www.ncbi.nlm.nih.gov/gene/?term=10549 "AOE37-2, AOE372, HEL-S-97n, PRX-4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001237 1054 CEBPG http://www.ncbi.nlm.nih.gov/gene/?term=1054 "GPE1BP, IG/EBP-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001238 105501 Abhd4 http://www.ncbi.nlm.nih.gov/gene/?term=105501 "1110035H23Rik, AI429574, Abh4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001239 105504 Exoc5 http://www.ncbi.nlm.nih.gov/gene/?term=105504 "AI447711, AI448003, Gm76, PRO1912, SEC10, Sec10l1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001240 10550 ARL6IP5 http://www.ncbi.nlm.nih.gov/gene/?term=10550 "DERP11, GTRAP3-18, HSPC127, JWA, PRAF3, Yip6b, addicsin, hp22, jmx " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001241 10550 ARL6IP5 http://www.ncbi.nlm.nih.gov/gene/?term=10550 "DERP11, GTRAP3-18, HSPC127, JWA, PRAF3, Yip6b, addicsin, hp22, jmx " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001242 10551 AGR2 http://www.ncbi.nlm.nih.gov/gene/?term=10551 "AG2, GOB-4, HAG-2, HEL-S-116, PDIA17, XAG-2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001243 10551 AGR2 http://www.ncbi.nlm.nih.gov/gene/?term=10551 "AG2, GOB-4, HAG-2, HEL-S-116, PDIA17, XAG-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001244 105522 Ankrd28 http://www.ncbi.nlm.nih.gov/gene/?term=105522 "AI465466, AI604979, E430019N21Rik, mKIAA0379 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001245 10552 ARPC1A http://www.ncbi.nlm.nih.gov/gene/?term=10552 "Arc40, HEL-68, HEL-S-307, SOP2Hs, SOP2L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001246 10552 ARPC1A http://www.ncbi.nlm.nih.gov/gene/?term=10552 "Arc40, HEL-68, HEL-S-307, SOP2Hs, SOP2L " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001247 10552 ARPC1A http://www.ncbi.nlm.nih.gov/gene/?term=10552 "Arc40, HEL-68, HEL-S-307, SOP2Hs, SOP2L " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001248 10553 HTATIP2 http://www.ncbi.nlm.nih.gov/gene/?term=10553 "CC3, SDR44U1, TIP30 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001249 10554 AGPAT1 http://www.ncbi.nlm.nih.gov/gene/?term=10554 "1-AGPAT1, G15, LPAAT-alpha, LPAATA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001250 10554 AGPAT1 http://www.ncbi.nlm.nih.gov/gene/?term=10554 "1-AGPAT1, G15, LPAAT-alpha, LPAATA " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001251 105559 Mbnl2 http://www.ncbi.nlm.nih.gov/gene/?term=105559 "1110002M11Rik, AI047808, AI837313, AI849185, AL118326, MBLL, R75232, mKIAA4072 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001252 10555 AGPAT2 http://www.ncbi.nlm.nih.gov/gene/?term=10555 "1-AGPAT2, BSCL, BSCL1, LPAAB, LPAAT-beta " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001253 10556 RPP30 http://www.ncbi.nlm.nih.gov/gene/?term=10556 TSG15 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001254 10556 RPP30 http://www.ncbi.nlm.nih.gov/gene/?term=10556 TSG15 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001255 10556 RPP30 http://www.ncbi.nlm.nih.gov/gene/?term=10556 TSG15 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001256 10556 RPP30 http://www.ncbi.nlm.nih.gov/gene/?term=10556 TSG15 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001257 10558 SPTLC1 http://www.ncbi.nlm.nih.gov/gene/?term=10558 "HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001258 10558 SPTLC1 http://www.ncbi.nlm.nih.gov/gene/?term=10558 "HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001259 10558 SPTLC1 http://www.ncbi.nlm.nih.gov/gene/?term=10558 "HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001260 10559 SLC35A1 http://www.ncbi.nlm.nih.gov/gene/?term=10559 "CDG2F, CMPST, CST, hCST " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001261 10559 SLC35A1 http://www.ncbi.nlm.nih.gov/gene/?term=10559 "CDG2F, CMPST, CST, hCST " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001262 10560 SLC19A2 http://www.ncbi.nlm.nih.gov/gene/?term=10560 "TC1, THMD1, THT1, THTR1, TRMA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001263 10564 ARFGEF2 http://www.ncbi.nlm.nih.gov/gene/?term=10564 "BIG2, PVNH2, dJ1164I10.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001264 10564 ARFGEF2 http://www.ncbi.nlm.nih.gov/gene/?term=10564 "BIG2, PVNH2, dJ1164I10.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001265 105653 Phyhip http://www.ncbi.nlm.nih.gov/gene/?term=105653 "AW049870, C630010D02Rik, Lnap1ip, PAHX-AP#1, PAHX-AP1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001266 10565 ARFGEF1 http://www.ncbi.nlm.nih.gov/gene/?term=10565 "ARFGEP1, BIG1, P200 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001267 10565 ARFGEF1 http://www.ncbi.nlm.nih.gov/gene/?term=10565 "ARFGEP1, BIG1, P200 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001268 10566 AKAP3 http://www.ncbi.nlm.nih.gov/gene/?term=10566 "AKAP 110, AKAP110, CT82, FSP95, HEL159, PRKA3, SOB1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001269 10566 AKAP3 http://www.ncbi.nlm.nih.gov/gene/?term=10566 "AKAP 110, AKAP110, CT82, FSP95, HEL159, PRKA3, SOB1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001270 10567 RABAC1 http://www.ncbi.nlm.nih.gov/gene/?term=10567 "PRA1, PRAF1, YIP3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001271 105689 Mycbp2 http://www.ncbi.nlm.nih.gov/gene/?term=105689 "AU023734, AW107953, AW546647, C130061D10Rik, Pam, Phr1, R75243 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001272 105689 Mycbp2 http://www.ncbi.nlm.nih.gov/gene/?term=105689 "AU023734, AW107953, AW546647, C130061D10Rik, Pam, Phr1, R75243 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001273 10569 SLU7 http://www.ncbi.nlm.nih.gov/gene/?term=10569 "9G8, hSlu7 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001274 10569 SLU7 http://www.ncbi.nlm.nih.gov/gene/?term=10569 "9G8, hSlu7 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001275 10570 DPYSL4 http://www.ncbi.nlm.nih.gov/gene/?term=10570 "CRMP3, DRP-4, ULIP4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001276 105722 Ano6 http://www.ncbi.nlm.nih.gov/gene/?term=105722 "2900059G15Rik, AA407480, AW554778, F730003B03Rik, Tmem16f " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001277 105727 Slc38a1 http://www.ncbi.nlm.nih.gov/gene/?term=105727 "AA408026, AA409865, AL022800, AU015942, NAT2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001278 105727 Slc38a1 http://www.ncbi.nlm.nih.gov/gene/?term=105727 "AA408026, AA409865, AL022800, AU015942, NAT2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001279 10572 SIVA1 http://www.ncbi.nlm.nih.gov/gene/?term=10572 "CD27BP, SIVA, Siva-1, Siva-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001280 10572 SIVA1 http://www.ncbi.nlm.nih.gov/gene/?term=10572 "CD27BP, SIVA, Siva-1, Siva-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001281 10572 SIVA1 http://www.ncbi.nlm.nih.gov/gene/?term=10572 "CD27BP, SIVA, Siva-1, Siva-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001282 10573 MRPL28 http://www.ncbi.nlm.nih.gov/gene/?term=10573 "MAAT1, p15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001283 10574 CCT7 http://www.ncbi.nlm.nih.gov/gene/?term=10574 "CCTETA, CCTH, NIP7-1, TCP1ETA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001284 10574 CCT7 http://www.ncbi.nlm.nih.gov/gene/?term=10574 "CCTETA, CCTH, NIP7-1, TCP1ETA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001285 10574 CCT7 http://www.ncbi.nlm.nih.gov/gene/?term=10574 "CCTETA, CCTH, NIP7-1, TCP1ETA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001286 10575 CCT4 http://www.ncbi.nlm.nih.gov/gene/?term=10575 "CCT-DELTA, Cctd, SRB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001287 10575 CCT4 http://www.ncbi.nlm.nih.gov/gene/?term=10575 "CCT-DELTA, Cctd, SRB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001288 10575 CCT4 http://www.ncbi.nlm.nih.gov/gene/?term=10575 "CCT-DELTA, Cctd, SRB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001289 10576 CCT2 http://www.ncbi.nlm.nih.gov/gene/?term=10576 "99D8.1, CCT-beta, CCTB, HEL-S-100n, PRO1633, TCP-1-beta " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001290 10576 CCT2 http://www.ncbi.nlm.nih.gov/gene/?term=10576 "99D8.1, CCT-beta, CCTB, HEL-S-100n, PRO1633, TCP-1-beta " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001291 10577 NPC2 http://www.ncbi.nlm.nih.gov/gene/?term=10577 "EDDM1, HE1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001292 10577 NPC2 http://www.ncbi.nlm.nih.gov/gene/?term=10577 "EDDM1, HE1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001293 10577 NPC2 http://www.ncbi.nlm.nih.gov/gene/?term=10577 "EDDM1, HE1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001294 10580 SORBS1 http://www.ncbi.nlm.nih.gov/gene/?term=10580 "CAP, FLAF2, R85FL, SH3D5, SH3P12, SORB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001295 10580 SORBS1 http://www.ncbi.nlm.nih.gov/gene/?term=10580 "CAP, FLAF2, R85FL, SH3D5, SH3P12, SORB1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001296 10580 SORBS1 http://www.ncbi.nlm.nih.gov/gene/?term=10580 "CAP, FLAF2, R85FL, SH3D5, SH3P12, SORB1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001297 10581 IFITM2 http://www.ncbi.nlm.nih.gov/gene/?term=10581 "1-8D, DSPA2c " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001298 10581 IFITM2 http://www.ncbi.nlm.nih.gov/gene/?term=10581 "1-8D, DSPA2c " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001299 105837 Mtbp http://www.ncbi.nlm.nih.gov/gene/?term=105837 "AI429604, MDM2BP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001300 10585 POMT1 http://www.ncbi.nlm.nih.gov/gene/?term=10585 "LGMD2K, MDDGA1, MDDGB1, MDDGC1, RT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001301 10585 POMT1 http://www.ncbi.nlm.nih.gov/gene/?term=10585 "LGMD2K, MDDGA1, MDDGB1, MDDGC1, RT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001302 10587 TXNRD2 http://www.ncbi.nlm.nih.gov/gene/?term=10587 "SELZ, TR, TR-BETA, TR3, TRXR2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001303 10589 DRAP1 http://www.ncbi.nlm.nih.gov/gene/?term=10589 NC2-alpha mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001304 10589 DRAP1 http://www.ncbi.nlm.nih.gov/gene/?term=10589 NC2-alpha mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001305 1058 CENPA http://www.ncbi.nlm.nih.gov/gene/?term=1058 "CENP-A, CenH3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001306 10591 DNPH1 http://www.ncbi.nlm.nih.gov/gene/?term=10591 "C6orf108, RCL, dJ330M21.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001307 10591 DNPH1 http://www.ncbi.nlm.nih.gov/gene/?term=10591 "C6orf108, RCL, dJ330M21.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001308 10592 SMC2 http://www.ncbi.nlm.nih.gov/gene/?term=10592 "CAP-E, CAPE, SMC-2, SMC2L1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001309 10592 SMC2 http://www.ncbi.nlm.nih.gov/gene/?term=10592 "CAP-E, CAPE, SMC-2L1, SMC2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001310 10592 SMC2 http://www.ncbi.nlm.nih.gov/gene/?term=10592 "CAP-E, CAPE, SMC-2L1, SMC2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001311 10594 PRPF8 http://www.ncbi.nlm.nih.gov/gene/?term=10594 "HPRP8, PRP8, PRPC8, RP13, SNRNP220 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001312 10594 PRPF8 http://www.ncbi.nlm.nih.gov/gene/?term=10594 "HPRP8, PRP8, PRPC8, RP13, SNRNP220 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001313 10595 ERN2 http://www.ncbi.nlm.nih.gov/gene/?term=10595 "IRE1-BETA, IRE1b, IRE2p, hIRE2p " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001314 10595 ERN2 http://www.ncbi.nlm.nih.gov/gene/?term=10595 "IRE1-BETA, IRE1b, IRE2p, hIRE2p " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001315 105968 AU021063 http://www.ncbi.nlm.nih.gov/gene/?term=105968 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001316 10598 AHSA1 http://www.ncbi.nlm.nih.gov/gene/?term=10598 "AHA1, C14orf3, hAha1, p38 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001317 1059 CENPB http://www.ncbi.nlm.nih.gov/gene/?term=1059 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001318 1059 CENPB http://www.ncbi.nlm.nih.gov/gene/?term=1059 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001319 10600 USP16 http://www.ncbi.nlm.nih.gov/gene/?term=10600 "UBP-M, UBPM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001320 10600 USP16 http://www.ncbi.nlm.nih.gov/gene/?term=10600 "UBP-M, UBPM " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001321 10600 USP16 http://www.ncbi.nlm.nih.gov/gene/?term=10600 "UBP-M, UBPM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001322 106039 Gga1 http://www.ncbi.nlm.nih.gov/gene/?term=106039 "4930406E12Rik, AU016030, AW209092 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001323 10605 PAIP1 http://www.ncbi.nlm.nih.gov/gene/?term=10605 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001324 10605 PAIP1 http://www.ncbi.nlm.nih.gov/gene/?term=10605 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001325 106064 AW549877 http://www.ncbi.nlm.nih.gov/gene/?term=106064 AI195826 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001326 10606 PAICS http://www.ncbi.nlm.nih.gov/gene/?term=10606 "ADE2, ADE2H1, AIRC, PAIS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001327 10606 PAICS http://www.ncbi.nlm.nih.gov/gene/?term=10606 "ADE2, ADE2H1, AIRC, PAIS " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001328 10606 PAICS http://www.ncbi.nlm.nih.gov/gene/?term=10606 "ADE2, ADE2H1, AIRC, PAIS " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001329 10606 PAICS http://www.ncbi.nlm.nih.gov/gene/?term=10606 "ADE2, ADE2H1, AIRC, PAIS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001330 10607 TBL3 http://www.ncbi.nlm.nih.gov/gene/?term=10607 "SAZD, UTP13 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001331 10608 MXD4 http://www.ncbi.nlm.nih.gov/gene/?term=10608 "MAD4, MST149, MSTP149, bHLHc12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001332 10608 MXD4 http://www.ncbi.nlm.nih.gov/gene/?term=10608 "MAD4, MST149, MSTP149, bHLHc12 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001333 10609 P3H4 http://www.ncbi.nlm.nih.gov/gene/?term=10609 "LEPREL4, NO55, NOL55, SC65 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001334 10609 P3H4 http://www.ncbi.nlm.nih.gov/gene/?term=10609 "LEPREL4, NO55, NOL55, SC65 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001335 1060 CENPC http://www.ncbi.nlm.nih.gov/gene/?term=1060 "CENP-C, CENPC1, MIF2, hcp-4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001336 10611 PDLIM5 http://www.ncbi.nlm.nih.gov/gene/?term=10611 "ENH, ENH1, L9, LIM " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001337 10611 PDLIM5 http://www.ncbi.nlm.nih.gov/gene/?term=10611 "ENH, ENH1, L9, LIM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001338 10613 ERLIN1 http://www.ncbi.nlm.nih.gov/gene/?term=10613 "C10orf69, Erlin-1, KE04, KEO4, SPFH1, SPG62 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001339 106143 Cggbp1 http://www.ncbi.nlm.nih.gov/gene/?term=106143 "AA960172, AL023996, AW045841 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001340 106143 Cggbp1 http://www.ncbi.nlm.nih.gov/gene/?term=106143 "AA960172, AL023996, AW045841 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001341 10614 HEXIM1 http://www.ncbi.nlm.nih.gov/gene/?term=10614 "CLP1, EDG1, HIS1, MAQ1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001342 10614 HEXIM1 http://www.ncbi.nlm.nih.gov/gene/?term=10614 "CLP1, EDG1, HIS1, MAQ1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001343 10615 SPAG5 http://www.ncbi.nlm.nih.gov/gene/?term=10615 "DEEPEST, MAP126, hMAP126 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001344 10616 RBCK1 http://www.ncbi.nlm.nih.gov/gene/?term=10616 "C20orf18, HOIL-1, HOIL1, PBMEI, PGBM1, RBCK2, RNF54, UBCE7IP3, XAP3, XAP4, ZRANB4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001345 10616 RBCK1 http://www.ncbi.nlm.nih.gov/gene/?term=10616 "C20orf18, HOIL-1, HOIL1, PBMEI, PGBM1, RBCK2, RNF54, UBCE7IP3, XAP3, XAP4, ZRANB4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001346 10617 STAMBP http://www.ncbi.nlm.nih.gov/gene/?term=10617 "AMSH, MICCAP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001347 10617 STAMBP http://www.ncbi.nlm.nih.gov/gene/?term=10617 "AMSH, MICCAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001348 10618 TGOLN2 http://www.ncbi.nlm.nih.gov/gene/?term=10618 "TGN38, TGN46, TGN48, TGN51, TTGN2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001349 10618 TGOLN2 http://www.ncbi.nlm.nih.gov/gene/?term=10618 "TGN38, TGN46, TGN48, TGN51, TTGN2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001350 10618 TGOLN2 http://www.ncbi.nlm.nih.gov/gene/?term=10618 "TGN38, TGN46, TGN48, TGN51, TTGN2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001351 106205 Zc3h7a http://www.ncbi.nlm.nih.gov/gene/?term=106205 "A430104C18Rik, AI447294, AW556219, HSPC055, Zc3h7, Zc3hdc7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001352 10621 POLR3F http://www.ncbi.nlm.nih.gov/gene/?term=10621 "RPC39, RPC6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001353 10622 POLR3G http://www.ncbi.nlm.nih.gov/gene/?term=10622 "RPC32, RPC7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001354 10622 POLR3G http://www.ncbi.nlm.nih.gov/gene/?term=10622 "RPC32, RPC7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001355 10623 POLR3C http://www.ncbi.nlm.nih.gov/gene/?term=10623 "RPC3, RPC62 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001356 10625 IVNS1ABP http://www.ncbi.nlm.nih.gov/gene/?term=10625 "FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1-BP, NS1BP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001357 10625 IVNS1ABP http://www.ncbi.nlm.nih.gov/gene/?term=10625 "FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1-BP, NS1BP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001358 10627 MYL12A http://www.ncbi.nlm.nih.gov/gene/?term=10627 "HEL-S-24, MLC-2B, MLCB, MRCL3, MRLC3, MYL2B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001359 10628 TXNIP http://www.ncbi.nlm.nih.gov/gene/?term=10628 "EST01027, HHCPA78, THIF, VDUP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001360 10628 TXNIP http://www.ncbi.nlm.nih.gov/gene/?term=10628 "EST01027, HHCPA78, THIF, VDUP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001361 10629 TAF6L http://www.ncbi.nlm.nih.gov/gene/?term=10629 PAF65A mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001362 1062 CENPE http://www.ncbi.nlm.nih.gov/gene/?term=1062 "CENP-E, KIF10, MCPH13, PPP1R61 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001363 1062 CENPE http://www.ncbi.nlm.nih.gov/gene/?term=1062 "CENP-E, KIF10, MCPH13, PPP1R61 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001364 1062 CENPE http://www.ncbi.nlm.nih.gov/gene/?term=1062 "CENP-E, KIF10, MCPH13, PPP1R61 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001365 10630 PDPN http://www.ncbi.nlm.nih.gov/gene/?term=10630 "AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001366 10630 PDPN http://www.ncbi.nlm.nih.gov/gene/?term=10630 "AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001367 10630 PDPN http://www.ncbi.nlm.nih.gov/gene/?term=10630 "AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001368 10632 ATP5L http://www.ncbi.nlm.nih.gov/gene/?term=10632 ATP5JG mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001369 10634 GAS2L1 http://www.ncbi.nlm.nih.gov/gene/?term=10634 GAR22 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001370 10635 RAD51AP1 http://www.ncbi.nlm.nih.gov/gene/?term=10635 PIR51 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001371 1063 CENPF http://www.ncbi.nlm.nih.gov/gene/?term=1063 "CENF, CILD31, PRO1779, STROMS, hcp-1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001372 1063 CENPF http://www.ncbi.nlm.nih.gov/gene/?term=1063 "CENF, CILD31, PRO1779, hcp-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001373 10640 EXOC5 http://www.ncbi.nlm.nih.gov/gene/?term=10640 "HSEC10, PRO1912, SEC10, SEC10L1, SEC10P " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001374 10640 EXOC5 http://www.ncbi.nlm.nih.gov/gene/?term=10640 "HSEC10, PRO1912, SEC10, SEC10L1, SEC10P " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001375 10640 EXOC5 http://www.ncbi.nlm.nih.gov/gene/?term=10640 "HSEC10, PRO1912, SEC10, SEC10L1, SEC10P " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001376 10642 IGF2BP1 http://www.ncbi.nlm.nih.gov/gene/?term=10642 "CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001377 10642 IGF2BP1 http://www.ncbi.nlm.nih.gov/gene/?term=10642 "CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001378 10645 CAMKK2 http://www.ncbi.nlm.nih.gov/gene/?term=10645 "CAMKK, CAMKKB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001379 10645 CAMKK2 http://www.ncbi.nlm.nih.gov/gene/?term=10645 "CAMKK, CAMKKB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001380 106504 Stk38 http://www.ncbi.nlm.nih.gov/gene/?term=106504 "5830476G13Rik, 9530097A09Rik, AA617404, Ndr1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001381 10651 MTX2 http://www.ncbi.nlm.nih.gov/gene/?term=10651 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001382 10651 MTX2 http://www.ncbi.nlm.nih.gov/gene/?term=10651 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001383 10651 MTX2 http://www.ncbi.nlm.nih.gov/gene/?term=10651 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001384 10652 YKT6 http://www.ncbi.nlm.nih.gov/gene/?term=10652 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001385 10652 YKT6 http://www.ncbi.nlm.nih.gov/gene/?term=10652 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001386 10653 SPINT2 http://www.ncbi.nlm.nih.gov/gene/?term=10653 "DIAR3, HAI-2, HAI2, Kop, PB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001387 10653 SPINT2 http://www.ncbi.nlm.nih.gov/gene/?term=10653 "DIAR3, HAI-2, HAI2, Kop, PB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001388 10654 PMVK http://www.ncbi.nlm.nih.gov/gene/?term=10654 "HUMPMKI, PMK, PMKA, PMKASE, POROK1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001389 10654 PMVK http://www.ncbi.nlm.nih.gov/gene/?term=10654 "HUMPMKI, PMK, PMKA, PMKASE, POROK1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001390 10655 DMRT2 http://www.ncbi.nlm.nih.gov/gene/?term=10655 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001391 10657 KHDRBS1 http://www.ncbi.nlm.nih.gov/gene/?term=10657 "Sam68, p62, p68 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001392 106585 Ankrd12 http://www.ncbi.nlm.nih.gov/gene/?term=106585 "2900001A12Rik, AI447928, ANCO-2, AV347965, GAC-1, mKIAA0874 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001393 10658 CELF1 http://www.ncbi.nlm.nih.gov/gene/?term=10658 "BRUNOL2, CUG-BP, CUGBP, CUGBP1, EDEN-BP, NAB50, NAPOR, hNab50 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001394 10658 CELF1 http://www.ncbi.nlm.nih.gov/gene/?term=10658 "BRUNOL2, CUG-BP, CUGBP, CUGBP1, EDEN-BP, NAB50, NAPOR, hNab50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001395 10659 CELF2 http://www.ncbi.nlm.nih.gov/gene/?term=10659 "BRUNOL3, CUGBP2, ETR-3, ETR3, NAPOR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001396 10661 KLF1 http://www.ncbi.nlm.nih.gov/gene/?term=10661 "CDAN4, EKLF, HBFQTL6, INLU " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001397 106631781 RNA18S4 http://www.ncbi.nlm.nih.gov/gene/?term=106631781 rRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001398 106631781 RNA18S4 http://www.ncbi.nlm.nih.gov/gene/?term=106631781 rRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001399 106631781 RNA18S4 http://www.ncbi.nlm.nih.gov/gene/?term=106631781 rRNA Homo sapiens 25753659 Cytoplasm HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001400 106631781 RNA18S4 http://www.ncbi.nlm.nih.gov/gene/?term=106631781 rRNA Homo sapiens 25753659 Ribosome HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001401 106631782 RNA18S3 http://www.ncbi.nlm.nih.gov/gene/?term=106631782 rRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001402 106631782 RNA18S3 http://www.ncbi.nlm.nih.gov/gene/?term=106631782 rRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001403 106631782 RNA18S3 http://www.ncbi.nlm.nih.gov/gene/?term=106631782 rRNA Homo sapiens 25753659 Cytoplasm HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001404 106631782 RNA18S3 http://www.ncbi.nlm.nih.gov/gene/?term=106631782 rRNA Homo sapiens 25753659 Ribosome HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001405 106632258 RNA18S2 http://www.ncbi.nlm.nih.gov/gene/?term=106632258 rRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001406 106632258 RNA18S2 http://www.ncbi.nlm.nih.gov/gene/?term=106632258 rRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001407 106632258 RNA18S2 http://www.ncbi.nlm.nih.gov/gene/?term=106632258 rRNA Homo sapiens 25753659 Cytoplasm HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001408 106632258 RNA18S2 http://www.ncbi.nlm.nih.gov/gene/?term=106632258 rRNA Homo sapiens 25753659 Ribosome HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001409 106632259 RNA18S1 http://www.ncbi.nlm.nih.gov/gene/?term=106632259 rRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001410 106632259 RNA18S1 http://www.ncbi.nlm.nih.gov/gene/?term=106632259 rRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001411 106632259 RNA18S1 http://www.ncbi.nlm.nih.gov/gene/?term=106632259 rRNA Homo sapiens 25753659 Cytoplasm HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001412 106632259 RNA18S1 http://www.ncbi.nlm.nih.gov/gene/?term=106632259 rRNA Homo sapiens 25753659 Ribosome HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001413 106632260 RNA5-8S4 http://www.ncbi.nlm.nih.gov/gene/?term=106632260 rRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001414 106632260 RNA5-8S4 http://www.ncbi.nlm.nih.gov/gene/?term=106632260 rRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001415 106632261 RNA5-8S3 http://www.ncbi.nlm.nih.gov/gene/?term=106632261 rRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001416 106632261 RNA5-8S3 http://www.ncbi.nlm.nih.gov/gene/?term=106632261 rRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001417 106632262 RNA5-8S2 http://www.ncbi.nlm.nih.gov/gene/?term=106632262 rRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001418 106632262 RNA5-8S2 http://www.ncbi.nlm.nih.gov/gene/?term=106632262 rRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001419 106632263 RNA5-8S1 http://www.ncbi.nlm.nih.gov/gene/?term=106632263 rRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001420 106632263 RNA5-8S1 http://www.ncbi.nlm.nih.gov/gene/?term=106632263 rRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001421 106632264 RNA28S4 http://www.ncbi.nlm.nih.gov/gene/?term=106632264 rRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001422 106632264 RNA28S4 http://www.ncbi.nlm.nih.gov/gene/?term=106632264 rRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001423 106632264 RNA28S4 http://www.ncbi.nlm.nih.gov/gene/?term=106632264 rRNA Homo sapiens 25753659 Cytoplasm HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001424 106632264 RNA28S4 http://www.ncbi.nlm.nih.gov/gene/?term=106632264 rRNA Homo sapiens 25753659 Ribosome HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001425 106632265 RNA28S3 http://www.ncbi.nlm.nih.gov/gene/?term=106632265 rRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001426 106632265 RNA28S3 http://www.ncbi.nlm.nih.gov/gene/?term=106632265 rRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001427 106632265 RNA28S3 http://www.ncbi.nlm.nih.gov/gene/?term=106632265 rRNA Homo sapiens 25753659 Cytoplasm HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001428 106632265 RNA28S3 http://www.ncbi.nlm.nih.gov/gene/?term=106632265 rRNA Homo sapiens 25753659 Ribosome HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001429 106632266 RNA28S2 http://www.ncbi.nlm.nih.gov/gene/?term=106632266 rRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001430 106632266 RNA28S2 http://www.ncbi.nlm.nih.gov/gene/?term=106632266 rRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001431 106632266 RNA28S2 http://www.ncbi.nlm.nih.gov/gene/?term=106632266 rRNA Homo sapiens 25753659 Cytoplasm HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001432 106632266 RNA28S2 http://www.ncbi.nlm.nih.gov/gene/?term=106632266 rRNA Homo sapiens 25753659 Ribosome HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001433 106632267 RNA28S1 http://www.ncbi.nlm.nih.gov/gene/?term=106632267 rRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001434 106632267 RNA28S1 http://www.ncbi.nlm.nih.gov/gene/?term=106632267 rRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001435 106632267 RNA28S1 http://www.ncbi.nlm.nih.gov/gene/?term=106632267 rRNA Homo sapiens 25753659 Cytoplasm HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001436 106632267 RNA28S1 http://www.ncbi.nlm.nih.gov/gene/?term=106632267 rRNA Homo sapiens 25753659 Ribosome HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00001437 106633806 SNORD142 http://www.ncbi.nlm.nih.gov/gene/?term=106633806 "SNORA85, SNORD174, ZL68 " snoRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00001438 106633806 SNORD142 http://www.ncbi.nlm.nih.gov/gene/?term=106633806 "SNORA85, SNORD174, ZL68 " snoRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00001439 10664 CTCF http://www.ncbi.nlm.nih.gov/gene/?term=10664 MRD21 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001440 10664 CTCF http://www.ncbi.nlm.nih.gov/gene/?term=10664 MRD21 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001441 10667 FARS2 http://www.ncbi.nlm.nih.gov/gene/?term=10667 "COXPD14, FARS1, HSPC320, PheRS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001442 10667 FARS2 http://www.ncbi.nlm.nih.gov/gene/?term=10667 "COXPD14, FARS1, HSPC320, PheRS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001443 10667 FARS2 http://www.ncbi.nlm.nih.gov/gene/?term=10667 "COXPD14, FARS1, HSPC320, PheRS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001444 10668 CGRRF1 http://www.ncbi.nlm.nih.gov/gene/?term=10668 "CGR19, RNF197 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001445 10669 CGREF1 http://www.ncbi.nlm.nih.gov/gene/?term=10669 CGR11 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001446 1066 CES1 http://www.ncbi.nlm.nih.gov/gene/?term=1066 "ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001447 106707 Rpusd1 http://www.ncbi.nlm.nih.gov/gene/?term=106707 "2310051D06Rik, AU019540, Rlucl " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001448 10670 RRAGA http://www.ncbi.nlm.nih.gov/gene/?term=10670 "FIP-1, FIP1, RAGA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001449 10671 DCTN6 http://www.ncbi.nlm.nih.gov/gene/?term=10671 "WS-3, WS3, p27 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001450 10672 GNA13 http://www.ncbi.nlm.nih.gov/gene/?term=10672 G13 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001451 10673 TNFSF13B http://www.ncbi.nlm.nih.gov/gene/?term=10673 "BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, TNLG7A, ZTNF4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001452 10675 CSPG5 http://www.ncbi.nlm.nih.gov/gene/?term=10675 NGC mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001453 10678 B3GNT2 http://www.ncbi.nlm.nih.gov/gene/?term=10678 "3-Gn-T1, 3-Gn-T2, B3GN-T2, B3GNT, B3GNT-2, B3GNT1, BETA3GNT, BGNT2, BGnT-2, beta-1, beta3Gn-T1, beta3Gn-T2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001454 10678 B3GNT2 http://www.ncbi.nlm.nih.gov/gene/?term=10678 "3-Gn-T1, 3-Gn-T2, B3GN-T2, B3GNT, B3GNT-2, B3GNT1, BETA3GNT, BGNT2, BGnT-2, beta-1, beta3Gn-T1, beta3Gn-T2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001455 10678 B3GNT2 http://www.ncbi.nlm.nih.gov/gene/?term=10678 "3-Gn-T1, 3-Gn-T2, B3GN-T2, B3GNT, B3GNT-2, B3GNT1, BETA3GNT, BGNT2, BGnT-2, beta-1, beta3Gn-T1, beta3Gn-T2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001456 106794 Dhx57 http://www.ncbi.nlm.nih.gov/gene/?term=106794 AW494914 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001457 10682 EBP http://www.ncbi.nlm.nih.gov/gene/?term=10682 "CDPX2, CHO2, CPX, CPXD, MEND " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001458 10682 EBP http://www.ncbi.nlm.nih.gov/gene/?term=10682 "CDPX2, CHO2, CPX, CPXD, MEND " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001459 10682 EBP http://www.ncbi.nlm.nih.gov/gene/?term=10682 "CDPX2, CHO2, CPX, CPXD, MEND " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001460 10687 PNMA2 http://www.ncbi.nlm.nih.gov/gene/?term=10687 "MA2, MM2, RGAG2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001461 10687 PNMA2 http://www.ncbi.nlm.nih.gov/gene/?term=10687 "MA2, MM2, RGAG2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001462 106885 AI314760 http://www.ncbi.nlm.nih.gov/gene/?term=106885 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001463 106885 AI314760 http://www.ncbi.nlm.nih.gov/gene/?term=106885 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001464 106885 AI314760 http://www.ncbi.nlm.nih.gov/gene/?term=106885 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001465 10691 GMEB1 http://www.ncbi.nlm.nih.gov/gene/?term=10691 "P96PIF, PIF96 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001466 10694 CCT8 http://www.ncbi.nlm.nih.gov/gene/?term=10694 "C21orf112, Cctq, D21S246, PRED71 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001467 10694 CCT8 http://www.ncbi.nlm.nih.gov/gene/?term=10694 "C21orf112, Cctq, D21S246, PRED71 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001468 10694 CCT8 http://www.ncbi.nlm.nih.gov/gene/?term=10694 "C21orf112, Cctq, D21S246, PRED71 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001469 106957 Slc39a6 http://www.ncbi.nlm.nih.gov/gene/?term=106957 Ermelin mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001470 10695 CNPY3 http://www.ncbi.nlm.nih.gov/gene/?term=10695 "CAG4A, ERDA5, PRAT4A, TNRC5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001471 10695 CNPY3 http://www.ncbi.nlm.nih.gov/gene/?term=10695 "CAG4A, ERDA5, PRAT4A, TNRC5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001472 10695 CNPY3 http://www.ncbi.nlm.nih.gov/gene/?term=10695 "CAG4A, ERDA5, PRAT4A, TNRC5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001473 10699 CORIN http://www.ncbi.nlm.nih.gov/gene/?term=10699 "ATC2, CRN, Lrp4, PEE5, TMPRSS10 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001474 1069 CETN2 http://www.ncbi.nlm.nih.gov/gene/?term=1069 "CALT, CEN2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001475 1069 CETN2 http://www.ncbi.nlm.nih.gov/gene/?term=1069 "CALT, CEN2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001476 107029 Me2 http://www.ncbi.nlm.nih.gov/gene/?term=107029 "AW120568, D030040L20Rik, NAD-ME " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001477 107045 Lars http://www.ncbi.nlm.nih.gov/gene/?term=107045 "2310045K21Rik, 3110009L02Rik, AW536573, mKIAA1352 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001478 1070 CETN3 http://www.ncbi.nlm.nih.gov/gene/?term=1070 "CDC31, CEN3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001479 107105261 RNU1-5P http://www.ncbi.nlm.nih.gov/gene/?term=107105261 RNU1-5 lncRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00001480 10712 FAM189B http://www.ncbi.nlm.nih.gov/gene/?term=10712 "C1orf2, COTE1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001481 10712 FAM189B http://www.ncbi.nlm.nih.gov/gene/?term=10712 "C1orf2, COTE1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001482 10713 USP39 http://www.ncbi.nlm.nih.gov/gene/?term=10713 "65K, CGI-21, HSPC332, SAD1, SNRNP65 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001483 10714 POLD3 http://www.ncbi.nlm.nih.gov/gene/?term=10714 "P66, P68, PPP1R128 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001484 10714 POLD3 http://www.ncbi.nlm.nih.gov/gene/?term=10714 "P66, P68, PPP1R128 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001485 10715 CERS1 http://www.ncbi.nlm.nih.gov/gene/?term=10715 "EPM8, LAG1, LASS1, UOG1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001486 107173 Gpr137 http://www.ncbi.nlm.nih.gov/gene/?term=107173 AI428855 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001487 107182 Btaf1 http://www.ncbi.nlm.nih.gov/gene/?term=107182 "AI414500, AI447930, E430027O22Rik, TAF170 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001488 107227 Macrod1 http://www.ncbi.nlm.nih.gov/gene/?term=107227 "AI604841, AW743046, D930010J01Rik, Lrp16 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001489 10723 SLC12A7 http://www.ncbi.nlm.nih.gov/gene/?term=10723 KCC4 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001490 10723 SLC12A7 http://www.ncbi.nlm.nih.gov/gene/?term=10723 KCC4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001491 107242 AI837181 http://www.ncbi.nlm.nih.gov/gene/?term=107242 "Bles03, N28173 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001492 10724 MGEA5 http://www.ncbi.nlm.nih.gov/gene/?term=10724 "MEA5, NCOAT, OGA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001493 10724 MGEA5 http://www.ncbi.nlm.nih.gov/gene/?term=10724 "MEA5, NCOAT, OGA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001494 10724 MGEA5 http://www.ncbi.nlm.nih.gov/gene/?term=10724 "MEA5, NCOAT, OGA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001495 10725 NFAT5 http://www.ncbi.nlm.nih.gov/gene/?term=10725 "NF-AT5, NFATL1, NFATZ, OREBP, TONEBP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001496 10725 NFAT5 http://www.ncbi.nlm.nih.gov/gene/?term=10725 "NF-AT5, NFATL1, NFATZ, OREBP, TONEBP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001497 10725 NFAT5 http://www.ncbi.nlm.nih.gov/gene/?term=10725 "NF-AT5, NFATL1, NFATZ, OREBP, TONEBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001498 107260 Otub1 http://www.ncbi.nlm.nih.gov/gene/?term=107260 AI850305 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001499 10726 NUDC http://www.ncbi.nlm.nih.gov/gene/?term=10726 "HNUDC, MNUDC, NPD011 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001500 10726 NUDC http://www.ncbi.nlm.nih.gov/gene/?term=10726 "HNUDC, MNUDC, NPD011 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001501 10726 NUDC http://www.ncbi.nlm.nih.gov/gene/?term=10726 "HNUDC, MNUDC, NPD011 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001502 10728 PTGES3 http://www.ncbi.nlm.nih.gov/gene/?term=10728 "P23, TEBP, cPGES " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001503 10728 PTGES3 http://www.ncbi.nlm.nih.gov/gene/?term=10728 "P23, TEBP, cPGES " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001504 10728 PTGES3 http://www.ncbi.nlm.nih.gov/gene/?term=10728 "P23, TEBP, cPGES " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001505 1072 CFL1 http://www.ncbi.nlm.nih.gov/gene/?term=1072 "CFL, HEL-S-15, cofilin " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001506 1072 CFL1 http://www.ncbi.nlm.nih.gov/gene/?term=1072 "CFL, HEL-S-15, cofilin " mRNA Homo sapiens 25908858 Cell leading edge Lung cancer cell In situ hybridization Localization of cofilin mRNA to the leading edge of migrating cells promotes directed cell migration. RLID00001507 1072 CFL1 http://www.ncbi.nlm.nih.gov/gene/?term=1072 "CFL, HEL-S-15, cofilin " mRNA Homo sapiens 25908858 Cell leading edge Lung carcinoma cell In situ hybridization We have found that cofilin-1 mRNA is rapidly localized to the leading edge of human lung carcinoma cells and that VICKZ family RNA-binding proteins help mediate this localization through specific interactions with the 3'UTR of cofilin mRNA. RLID00001508 1072 CFL1 http://www.ncbi.nlm.nih.gov/gene/?term=1072 "CFL, HEL-S-15, cofilin " mRNA Homo sapiens 25908858 Lamellipodium Lung cancer cell In situ hybridization Cofilin mRNA is rapidly localized to lamellipodia in motile cells RLID00001509 10730 YME1L1 http://www.ncbi.nlm.nih.gov/gene/?term=10730 "FTSH, MEG4, PAMP, YME1L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001510 10730 YME1L1 http://www.ncbi.nlm.nih.gov/gene/?term=10730 "FTSH, MEG4, PAMP, YME1L " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001511 107328 Trpt1 http://www.ncbi.nlm.nih.gov/gene/?term=107328 "AU079016, AW045591, Tpt1, Tpt1h " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001512 10733 PLK4 http://www.ncbi.nlm.nih.gov/gene/?term=10733 "MCCRP2, SAK, STK18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001513 107358 Tm9sf3 http://www.ncbi.nlm.nih.gov/gene/?term=107358 "1810073M23Rik, 2810031D16Rik, AI115521, AI413748, AW146116, AW549777, Smbp, mKIAA4036 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001514 10735 STAG2 http://www.ncbi.nlm.nih.gov/gene/?term=10735 "SA-2, SA2, SCC3B, bA517O1.1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001515 10735 STAG2 http://www.ncbi.nlm.nih.gov/gene/?term=10735 "SA-2, SA2, SCC3B, bA517O1.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001516 107373 Fam111a http://www.ncbi.nlm.nih.gov/gene/?term=107373 "4632417K18Rik, AW413625 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001517 107392 Brms1 http://www.ncbi.nlm.nih.gov/gene/?term=107392 "AV003220, AW554636 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001518 107392 Brms1 http://www.ncbi.nlm.nih.gov/gene/?term=107392 "AV003220, AW554636 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001519 1073 CFL2 http://www.ncbi.nlm.nih.gov/gene/?term=1073 NEM7 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001520 1073 CFL2 http://www.ncbi.nlm.nih.gov/gene/?term=1073 NEM7 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001521 10741 RBBP9 http://www.ncbi.nlm.nih.gov/gene/?term=10741 "BOG, RBBP10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001522 10741 RBBP9 http://www.ncbi.nlm.nih.gov/gene/?term=10741 "BOG, RBBP10 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001523 10741 RBBP9 http://www.ncbi.nlm.nih.gov/gene/?term=10741 "BOG, RBBP10 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001524 107435 Hat1 http://www.ncbi.nlm.nih.gov/gene/?term=107435 "2410071B14Rik, AA536933, Hat-1, KAT1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001525 107449 Unc5b http://www.ncbi.nlm.nih.gov/gene/?term=107449 "6330415E02Rik, A630020F16, D10Bwg0792e, Unc5h2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001526 10746 MAP3K2 http://www.ncbi.nlm.nih.gov/gene/?term=10746 "MEKK2, MEKK2B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001527 10746 MAP3K2 http://www.ncbi.nlm.nih.gov/gene/?term=10746 "MEKK2, MEKK2B " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001528 10746 MAP3K2 http://www.ncbi.nlm.nih.gov/gene/?term=10746 "MEKK2, MEKK2B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001529 10749 KIF1C http://www.ncbi.nlm.nih.gov/gene/?term=10749 "LTXS1, SATX2, SAX2, SPAX2, SPG58 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001530 10749 KIF1C http://www.ncbi.nlm.nih.gov/gene/?term=10749 "LTXS1, SATX2, SAX2, SPAX2, SPG58 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001531 107503 Atf5 http://www.ncbi.nlm.nih.gov/gene/?term=107503 "AFTA, Atf7, Atfx, ODA-10 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001532 107503 Atf5 http://www.ncbi.nlm.nih.gov/gene/?term=107503 "AFTA, Atf7, Atfx, ODA-10 " mRNA Mus musculus 18195013 Ribosome S/S MEF cell RT-PCR "In the non-stressed condition, when protein synthesis is plentiful, the ATF5 mRNA was associated with fewer ribosomes, as compared with the large polysomes associated with actin mRNA. In response to ER stress, ATF5 mRNA was readily detected in the larger polysome fractions, consistent with the idea that ATF5 mRNA was bound to multiple ribosomes and was more efficiently translated. " RLID00001533 107508 Eprs http://www.ncbi.nlm.nih.gov/gene/?term=107508 "2410081F06Rik, 3010002K18Rik, C79379, Qprs " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001534 107513 Ssr1 http://www.ncbi.nlm.nih.gov/gene/?term=107513 "2510001K09Rik, 6330400D04, AI159733, AI452176, SSR, TRAPA " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001535 107513 Ssr1 http://www.ncbi.nlm.nih.gov/gene/?term=107513 "2510001K09Rik, 6330400D04, AI159733, AI452176, SSR, TRAPA " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001536 107522 Ece2 http://www.ncbi.nlm.nih.gov/gene/?term=107522 "1810009K13Rik, 6330509A19Rik, 9630025D12Rik, BB127715, Ece-2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001537 107528 Magee1 http://www.ncbi.nlm.nih.gov/gene/?term=107528 "AI847422, DAMAGE, mMage-e1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001538 10752 CHL1 http://www.ncbi.nlm.nih.gov/gene/?term=10752 "CALL, L1CAM2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001539 10755 GIPC1 http://www.ncbi.nlm.nih.gov/gene/?term=10755 "C19orf3, GIPC, GLUT1CBP, Hs.6454, IIP-1, NIP, RGS19IP1, SEMCAP, SYNECTIIN, SYNECTIN, TIP-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001540 10755 GIPC1 http://www.ncbi.nlm.nih.gov/gene/?term=10755 "C19orf3, GIPC, GLUT1CBP, Hs.6454, IIP-1, NIP, RGS19IP1, SEMCAP, SYNECTIIN, SYNECTIN, TIP-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001541 10758 TRAF3IP2 http://www.ncbi.nlm.nih.gov/gene/?term=10758 "ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001542 10758 TRAF3IP2 http://www.ncbi.nlm.nih.gov/gene/?term=10758 "ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13 " mRNA Homo sapiens 26222413 Nucleus Neuron In situ hybridization|qRT-PCR "Interestingly, the subcellular distribution of TRAF3IP2 protein-coding transcript (from the strand opposite TRAF3IP2-AS1) was quite distinct from that of TRAF3IP2-AS1 transcript, being found throughout the nucleus, cytoplasm, and processes of DA neurons (Fig. 2i and j). " RLID00001543 10758 TRAF3IP2 http://www.ncbi.nlm.nih.gov/gene/?term=10758 "ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13 " mRNA Homo sapiens 26222413 Cytoplasm Neuron In situ hybridization|qRT-PCR "Interestingly, the subcellular distribution of TRAF3IP2 protein-coding transcript (from the strand opposite TRAF3IP2-AS1) was quite distinct from that of TRAF3IP2-AS1 transcript, being found throughout the nucleus, cytoplasm, and processes of DA neurons (Fig. 2i and j). " RLID00001544 1075 CTSC http://www.ncbi.nlm.nih.gov/gene/?term=1075 "CPPI, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001545 1075 CTSC http://www.ncbi.nlm.nih.gov/gene/?term=1075 "CPPI, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001546 1075 CTSC http://www.ncbi.nlm.nih.gov/gene/?term=1075 "CPPI, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001547 10761 PLAC1 http://www.ncbi.nlm.nih.gov/gene/?term=10761 "CT92, OOSP2L " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001548 10762 NUP50 http://www.ncbi.nlm.nih.gov/gene/?term=10762 "NPAP60, NPAP60L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001549 10762 NUP50 http://www.ncbi.nlm.nih.gov/gene/?term=10762 "NPAP60, NPAP60L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001550 107650 Pi4kb http://www.ncbi.nlm.nih.gov/gene/?term=107650 "ESTM41, PI4K-beta, PI4Kbeta, Pik4cb " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001551 10765 KDM5B http://www.ncbi.nlm.nih.gov/gene/?term=10765 "CT31, JARID1B, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A, RBP2-H1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001552 10766 TOB2 http://www.ncbi.nlm.nih.gov/gene/?term=10766 "TOB4, TOBL, TROB2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001553 10766 TOB2 http://www.ncbi.nlm.nih.gov/gene/?term=10766 "TOB4, TOBL, TROB2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001554 10767 HBS1L http://www.ncbi.nlm.nih.gov/gene/?term=10767 "EF-1a, ERFS, HBS1, HSPC276, eRF3c " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001555 10767 HBS1L http://www.ncbi.nlm.nih.gov/gene/?term=10767 "EF-1a, ERFS, HBS1, HSPC276, eRF3c " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001556 10767 HBS1L http://www.ncbi.nlm.nih.gov/gene/?term=10767 "EF-1a, ERFS, HBS1, HSPC276, eRF3c " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001557 10768 AHCYL1 http://www.ncbi.nlm.nih.gov/gene/?term=10768 "DCAL, IRBIT, PPP1R78, PRO0233, XPVKONA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001558 10768 AHCYL1 http://www.ncbi.nlm.nih.gov/gene/?term=10768 "DCAL, IRBIT, PPP1R78, PRO0233, XPVKONA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001559 10769 PLK2 http://www.ncbi.nlm.nih.gov/gene/?term=10769 "SNK, hPlk2, hSNK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001560 107701 Sf3b4 http://www.ncbi.nlm.nih.gov/gene/?term=107701 "SF3b49, SF3b50, Sap49 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001561 107701 Sf3b4 http://www.ncbi.nlm.nih.gov/gene/?term=107701 "SF3b49, SF3b50, Sap49 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001562 107702 Rnh1 http://www.ncbi.nlm.nih.gov/gene/?term=107702 "AW546468, C80305, RNH " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001563 10771 ZMYND11 http://www.ncbi.nlm.nih.gov/gene/?term=10771 "BRAM1, BS69, MRD30 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001564 10772 SRSF10 http://www.ncbi.nlm.nih.gov/gene/?term=10772 "FUSIP1, FUSIP2, NSSR, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR, TASR1, TASR2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001565 10772 SRSF10 http://www.ncbi.nlm.nih.gov/gene/?term=10772 "FUSIP1, FUSIP2, NSSR, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR, TASR1, TASR2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001566 10775 POP4 http://www.ncbi.nlm.nih.gov/gene/?term=10775 RPP29 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001567 10775 POP4 http://www.ncbi.nlm.nih.gov/gene/?term=10775 RPP29 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001568 107767 Scamp1 http://www.ncbi.nlm.nih.gov/gene/?term=107767 "4930505M11Rik, AI415563, AW122395 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001569 10776 ARPP19 http://www.ncbi.nlm.nih.gov/gene/?term=10776 "ARPP-16, ARPP-19, ARPP16, ENSAL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001570 10776 ARPP19 http://www.ncbi.nlm.nih.gov/gene/?term=10776 "ARPP-16, ARPP-19, ARPP16, ENSAL " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001571 10776 ARPP19 http://www.ncbi.nlm.nih.gov/gene/?term=10776 "ARPP-16, ARPP-19, ARPP16, ENSAL " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001572 10776 ARPP19 http://www.ncbi.nlm.nih.gov/gene/?term=10776 "ARPP-16, ARPP-19, ARPP16, ENSAL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001573 107770 Tm6sf2 http://www.ncbi.nlm.nih.gov/gene/?term=107770 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001574 107771 Bmyc http://www.ncbi.nlm.nih.gov/gene/?term=107771 "2900002K07Rik, AW060705, Mycb " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001575 107815 Scml2 http://www.ncbi.nlm.nih.gov/gene/?term=107815 4932420G07Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001576 10781 ZNF266 http://www.ncbi.nlm.nih.gov/gene/?term=10781 HZF1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001577 107823 Whsc1 http://www.ncbi.nlm.nih.gov/gene/?term=107823 "5830445G22Rik, 9430010A17Rik, AW555663, C130020C13Rik, D030027O06Rik, D930023B08Rik, MMSET, NSD2l, mKIAA1090, Whsc1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001578 10783 NEK6 http://www.ncbi.nlm.nih.gov/gene/?term=10783 SID6-1512 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001579 10787 NCKAP1 http://www.ncbi.nlm.nih.gov/gene/?term=10787 "HEM2, NAP1, NAP125, p125Nap1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001580 10788 IQGAP2 http://www.ncbi.nlm.nih.gov/gene/?term=10788 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001581 107932 Chd4 http://www.ncbi.nlm.nih.gov/gene/?term=107932 "9530019N15Rik, AA617397, BC005710, D6Ertd380e, Mi-2beta, mKIAA4075 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001582 10793 ZNF273 http://www.ncbi.nlm.nih.gov/gene/?term=10793 HZF9 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001583 10794 ZNF460 http://www.ncbi.nlm.nih.gov/gene/?term=10794 "HZF8, ZNF272 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001584 107971 Frs3 http://www.ncbi.nlm.nih.gov/gene/?term=107971 "4930417B13Rik, AI449674, Frs2beta, Snt2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001585 107975 Pacs1 http://www.ncbi.nlm.nih.gov/gene/?term=107975 AI325977 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001586 107976 Bre http://www.ncbi.nlm.nih.gov/gene/?term=107976 "6030405P19Rik, AI429776, B830038C02Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001587 10797 MTHFD2 http://www.ncbi.nlm.nih.gov/gene/?term=10797 NMDMC mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001588 10797 MTHFD2 http://www.ncbi.nlm.nih.gov/gene/?term=10797 NMDMC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001589 107986 Ddb2 http://www.ncbi.nlm.nih.gov/gene/?term=107986 2610043A19Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001590 107993 Bfsp2 http://www.ncbi.nlm.nih.gov/gene/?term=107993 "AI448593, CP49 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001591 10799 RPP40 http://www.ncbi.nlm.nih.gov/gene/?term=10799 "RNASEP1, bA428J1.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001592 108013 Celf4 http://www.ncbi.nlm.nih.gov/gene/?term=108013 "A230070D14Rik, BRUNOL-4, Brul4, Brunol4, C130060B05Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001593 10801 SEPT9 http://www.ncbi.nlm.nih.gov/gene/?term=10801 "AF17q25, MSF, MSF1, NAPB, PNUTL4, SINT1, SeptD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001594 10802 SEC24A http://www.ncbi.nlm.nih.gov/gene/?term=10802 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001595 10802 SEC24A http://www.ncbi.nlm.nih.gov/gene/?term=10802 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001596 108030 Lin7a http://www.ncbi.nlm.nih.gov/gene/?term=108030 "AI848705, LIN-7A, MALS-1, TIP-33, Veli, Veli1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001597 10807 SDCCAG3 http://www.ncbi.nlm.nih.gov/gene/?term=10807 NY-CO-3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001598 10807 SDCCAG3 http://www.ncbi.nlm.nih.gov/gene/?term=10807 NY-CO-3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001599 10807 SDCCAG3 http://www.ncbi.nlm.nih.gov/gene/?term=10807 NY-CO-3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001600 108086 Rnf216 http://www.ncbi.nlm.nih.gov/gene/?term=108086 "2810055G22Rik, AI647468, AU019462, C86502, F830018F18Rik, TRIAD3, UIP83, Ubce7ip1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001601 108089 Rnf144a http://www.ncbi.nlm.nih.gov/gene/?term=108089 "Rnf144, UIP4, Ubce7ip4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001602 10808 HSPH1 http://www.ncbi.nlm.nih.gov/gene/?term=10808 "HSP105, HSP105A, HSP105B, NY-CO-25 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001603 10808 HSPH1 http://www.ncbi.nlm.nih.gov/gene/?term=10808 "HSP105, HSP105A, HSP105B, NY-CO-25 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001604 10809 STARD10 http://www.ncbi.nlm.nih.gov/gene/?term=10809 "CGI-52, NY-CO-28, PCTP2, SDCCAG28 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001605 10809 STARD10 http://www.ncbi.nlm.nih.gov/gene/?term=10809 "CGI-52, NY-CO-28, PCTP2, SDCCAG28 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001606 108112 Eif4ebp3 http://www.ncbi.nlm.nih.gov/gene/?term=108112 4e-bp3 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001607 108116 Slco3a1 http://www.ncbi.nlm.nih.gov/gene/?term=108116 "5830414C08Rik, Anr1, MJAM, OATP-D, R75096, Slc21a11 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001608 108121 U2af1 http://www.ncbi.nlm.nih.gov/gene/?term=108121 "2010107D16Rik, 35kDa " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001609 108123 Napg http://www.ncbi.nlm.nih.gov/gene/?term=108123 "2400003O04Rik, SNARE " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001610 108138 Xrcc4 http://www.ncbi.nlm.nih.gov/gene/?term=108138 "2310057B22Rik, AW413319, AW545101 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001611 10813 UTP14A http://www.ncbi.nlm.nih.gov/gene/?term=10813 "NYCO16, SDCCAG16, dJ537K23.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001612 108150 Galnt7 http://www.ncbi.nlm.nih.gov/gene/?term=108150 AI225872 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001613 108154 Adamts6 http://www.ncbi.nlm.nih.gov/gene/?term=108154 "5031426K13, A930019D11Rik, ADAM-TS6, b2b1879.1Clo, b2b2029Clo, b2b2182Clo, b2b2187.1Clo, b2b2228Clo " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001614 10815 CPLX1 http://www.ncbi.nlm.nih.gov/gene/?term=10815 "CPX-I, CPX1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001615 10826 FAXDC2 http://www.ncbi.nlm.nih.gov/gene/?term=10826 C5orf4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001616 10827 FAM114A2 http://www.ncbi.nlm.nih.gov/gene/?term=10827 "133K02, C5orf3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001617 10838 ZNF275 http://www.ncbi.nlm.nih.gov/gene/?term=10838 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001618 10838 ZNF275 http://www.ncbi.nlm.nih.gov/gene/?term=10838 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001619 10844 TUBGCP2 http://www.ncbi.nlm.nih.gov/gene/?term=10844 "GCP-2, GCP2, Grip103, SPBC97, Spc97p, h103p, hGCP2, hSpc97 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001620 10845 CLPX http://www.ncbi.nlm.nih.gov/gene/?term=10845 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001621 10847 SRCAP http://www.ncbi.nlm.nih.gov/gene/?term=10847 "DOMO1, EAF1, FLHS, SWR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001622 10847 SRCAP http://www.ncbi.nlm.nih.gov/gene/?term=10847 "DOMO1, EAF1, FLHS, SWR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001623 10849 CD3EAP http://www.ncbi.nlm.nih.gov/gene/?term=10849 "ASE-1, ASE1, CAST, PAF49 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001624 10849 CD3EAP http://www.ncbi.nlm.nih.gov/gene/?term=10849 "ASE-1, ASE1, CAST, PAF49 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001625 10849 CD3EAP http://www.ncbi.nlm.nih.gov/gene/?term=10849 "ASE-1, ASE1, CAST, PAF49 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001626 10857 PGRMC1 http://www.ncbi.nlm.nih.gov/gene/?term=10857 "HPR6.6, MPR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001627 10857 PGRMC1 http://www.ncbi.nlm.nih.gov/gene/?term=10857 "HPR6.6, MPR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001628 10857 PGRMC1 http://www.ncbi.nlm.nih.gov/gene/?term=10857 "HPR6.6, MPR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001629 108645 Mat2b http://www.ncbi.nlm.nih.gov/gene/?term=108645 "1110064C04Rik, 2410018D16Rik, AI182287, AU022853, MAT-II, MATIIbeta, TGR " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001630 108652 Slc35b3 http://www.ncbi.nlm.nih.gov/gene/?term=108652 "4921526O06Rik, AI428480, CGI-19, PABST2, PAPST2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001631 108655 Foxp1 http://www.ncbi.nlm.nih.gov/gene/?term=108655 "3110052D19Rik, 4932443N09Rik, AI461938, AW494214 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001632 10865 ARID5A http://www.ncbi.nlm.nih.gov/gene/?term=10865 "MRF-1, MRF1, RP11-363D14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001633 108664 Atp6v1h http://www.ncbi.nlm.nih.gov/gene/?term=108664 "0710001F19Rik, AU022349, CGI-11, SFD, SFDalpha, SFDbeta, VMA13 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001634 108672 Zdhhc15 http://www.ncbi.nlm.nih.gov/gene/?term=108672 6030457O13Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001635 108686 Ccdc88a http://www.ncbi.nlm.nih.gov/gene/?term=108686 "A430106J12Rik, AI848406, Ape, C130096N06Rik, C330012F17Rik, D130005J21Rik, Girdin, Giv, Grdn, Hkrp1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001636 108699 Chn1 http://www.ncbi.nlm.nih.gov/gene/?term=108699 "0610007I19Rik, 0710001E19Rik, 1700112L09Rik, 2900046J01Rik, AI413815, ARHGAP2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001637 10869 USP19 http://www.ncbi.nlm.nih.gov/gene/?term=10869 ZMYND9 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001638 108707 Fam207a http://www.ncbi.nlm.nih.gov/gene/?term=108707 "1810008A18Rik, AI303072 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001639 10871 CD300C http://www.ncbi.nlm.nih.gov/gene/?term=10871 "CLM-6, CMRF-35, CMRF-35A, CMRF35, CMRF35-A1, CMRF35A, CMRF35A1, IGSF16, LIR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001640 10873 ME3 http://www.ncbi.nlm.nih.gov/gene/?term=10873 NADP-ME mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001641 10874 NMU http://www.ncbi.nlm.nih.gov/gene/?term=10874 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001642 10874 NMU http://www.ncbi.nlm.nih.gov/gene/?term=10874 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001643 108755 Lyrm2 http://www.ncbi.nlm.nih.gov/gene/?term=108755 2610208E05Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001644 10878 CFHR3 http://www.ncbi.nlm.nih.gov/gene/?term=10878 "CFHL3, DOWN16, FHR-3, FHR3, HLF4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001645 1087 CEACAM7 http://www.ncbi.nlm.nih.gov/gene/?term=1087 CGM2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001646 108803 4933402P03Rik http://www.ncbi.nlm.nih.gov/gene/?term=108803 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001647 108829 Jmjd1c http://www.ncbi.nlm.nih.gov/gene/?term=108829 "5430433L24Rik, D630035I23Rik, Jmjdic, TRIP8 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001648 10884 MRPS30 http://www.ncbi.nlm.nih.gov/gene/?term=10884 "MRP-S30, PAP, PDCD9, S30mt " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001649 108853 Mtrf1l http://www.ncbi.nlm.nih.gov/gene/?term=108853 9130004K12Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001650 108857 Ankhd1 http://www.ncbi.nlm.nih.gov/gene/?term=108857 "1110004O12Rik, 4933432B13Rik, 9130019P20Rik, A530027J04Rik, A630021B20Rik, AA571404, Mask, mFLJ00246, mKIAA1085 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001651 10885 WDR3 http://www.ncbi.nlm.nih.gov/gene/?term=10885 "DIP2, UTP12 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001652 10888 GPR83 http://www.ncbi.nlm.nih.gov/gene/?term=10888 "GIR, GPR72 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001653 10888 GPR83 http://www.ncbi.nlm.nih.gov/gene/?term=10888 "GIR, GPR72 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001654 10888 GPR83 http://www.ncbi.nlm.nih.gov/gene/?term=10888 "GIR, GPR72 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001655 108897 Aif1l http://www.ncbi.nlm.nih.gov/gene/?term=108897 "2810003C17Rik, AI043124, C87647, Iba2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001656 1088 CEACAM8 http://www.ncbi.nlm.nih.gov/gene/?term=1088 "CD66b, CD67, CGM6, NCA-95 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001657 1088 CEACAM8 http://www.ncbi.nlm.nih.gov/gene/?term=1088 "CD66b, CD67, CGM6, NCA-95 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001658 10890 RAB10 http://www.ncbi.nlm.nih.gov/gene/?term=10890 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001659 108927 Lhfp http://www.ncbi.nlm.nih.gov/gene/?term=108927 "2810489O06Rik, AI194968 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001660 108934 Smim13 http://www.ncbi.nlm.nih.gov/gene/?term=108934 2900036K02Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001661 10893 MMP24 http://www.ncbi.nlm.nih.gov/gene/?term=10893 "MMP-24, MMP25, MT-MMP 5, MT-MMP5, MT5-MMP, MT5MMP, MTMMP5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001662 108943 Trmt10a http://www.ncbi.nlm.nih.gov/gene/?term=108943 "3110023L08Rik, AA794508, Rg9mtd2, Rnmtd2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001663 108954 Ppp1r15b http://www.ncbi.nlm.nih.gov/gene/?term=108954 "1810033K10Rik, AI606441, C530022L24Rik, CReP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001664 10897 YIF1A http://www.ncbi.nlm.nih.gov/gene/?term=10897 "54TM, FinGER7, YIF1, YIF1P " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001665 10897 YIF1A http://www.ncbi.nlm.nih.gov/gene/?term=10897 "54TM, FinGER7, YIF1, YIF1P " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001666 10897 YIF1A http://www.ncbi.nlm.nih.gov/gene/?term=10897 "54TM, FinGER7, YIF1, YIF1P " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001667 108989 Tpr http://www.ncbi.nlm.nih.gov/gene/?term=108989 "2610029M07Rik, C77892 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001668 10899 JTB http://www.ncbi.nlm.nih.gov/gene/?term=10899 "HJTB, HSPC222, PAR, hJT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001669 10899 JTB http://www.ncbi.nlm.nih.gov/gene/?term=10899 "HJTB, HSPC222, PAR, hJT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001670 109006 Ciapin1 http://www.ncbi.nlm.nih.gov/gene/?term=109006 "2810413N20Rik, AA617265, AU021794, anamorsin " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001671 10900 RUNDC3A http://www.ncbi.nlm.nih.gov/gene/?term=10900 "RAP2IP, RPIP-8, RPIP8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001672 109011 1700020M10Rik http://www.ncbi.nlm.nih.gov/gene/?term=109011 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001673 109019 Nabp1 http://www.ncbi.nlm.nih.gov/gene/?term=109019 "4930434H03Rik, 4930442A21Rik, 4930488J04Rik, 4933440J18Rik, 5830411E10Rik, AI852561, Nbp1, Obfc2a, Ssb2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001674 10901 DHRS4 http://www.ncbi.nlm.nih.gov/gene/?term=10901 "CR, NRDR, PHCR, PSCD, SCAD-SRL, SDR-SRL, SDR25C1, SDR25C2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001675 10901 DHRS4 http://www.ncbi.nlm.nih.gov/gene/?term=10901 "CR, NRDR, PHCR, PSCD, SCAD-SRL, SDR-SRL, SDR25C1, SDR25C2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001676 10902 BRD8 http://www.ncbi.nlm.nih.gov/gene/?term=10902 "SMAP, SMAP2, p120 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001677 10902 BRD8 http://www.ncbi.nlm.nih.gov/gene/?term=10902 "SMAP, SMAP2, p120 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001678 10904 BLCAP http://www.ncbi.nlm.nih.gov/gene/?term=10904 BC10 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001679 10905 MAN1A2 http://www.ncbi.nlm.nih.gov/gene/?term=10905 MAN1B mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001680 10905 MAN1A2 http://www.ncbi.nlm.nih.gov/gene/?term=10905 MAN1B mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001681 10906 TRAFD1 http://www.ncbi.nlm.nih.gov/gene/?term=10906 FLN29 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001682 109075 Exosc4 http://www.ncbi.nlm.nih.gov/gene/?term=109075 "1110039I09Rik, 1500001N04Rik, Rrp41 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001683 109077 Ints5 http://www.ncbi.nlm.nih.gov/gene/?term=109077 "1110055N21Rik, mKIAA1698 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001684 109077 Ints5 http://www.ncbi.nlm.nih.gov/gene/?term=109077 "1110055N21Rik, mKIAA1698 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001685 10907 TXNL4A http://www.ncbi.nlm.nih.gov/gene/?term=10907 "BMKS, DIB1, DIM1, SNRNP15, TXNL4, U5-15kD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001686 10908 PNPLA6 http://www.ncbi.nlm.nih.gov/gene/?term=10908 "BNHS, LNMS, NTE, NTEMND, OMCS, SPG39, iPLA2delta, sws " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001687 10908 PNPLA6 http://www.ncbi.nlm.nih.gov/gene/?term=10908 "BNHS, LNMS, NTE, NTEMND, OMCS, SPG39, iPLA2delta, sws " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001688 109095 Rbm15b http://www.ncbi.nlm.nih.gov/gene/?term=109095 1810017N16Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001689 109108 Slc30a9 http://www.ncbi.nlm.nih.gov/gene/?term=109108 "2310024J23Rik, AL024256, GAC63, HUEL, znT-9 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001690 10910 SUGT1 http://www.ncbi.nlm.nih.gov/gene/?term=10910 SGT1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001691 10910 SUGT1 http://www.ncbi.nlm.nih.gov/gene/?term=10910 SGT1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001692 10910 SUGT1 http://www.ncbi.nlm.nih.gov/gene/?term=10910 SGT1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001693 109113 Uhrf2 http://www.ncbi.nlm.nih.gov/gene/?term=109113 "2310065A22Rik, AI426270, AW214556, D130071B19Rik, Nirf " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001694 109115 Supt3 http://www.ncbi.nlm.nih.gov/gene/?term=109115 "2310066G22Rik, AI315192, SPT3, SPT3Lh, Supt3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001695 10911 UTS2 http://www.ncbi.nlm.nih.gov/gene/?term=10911 "PRO1068, U-II, UCN2, UII " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001696 109135 Plekha5 http://www.ncbi.nlm.nih.gov/gene/?term=109135 "2810431N21Rik, AI428202, AK129423, AMH-Cre, Ayu21-9, Gt(pU21)9Imeg, Pepp2, Tg(AMH-cre)1Flor " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001697 10914 PAPOLA http://www.ncbi.nlm.nih.gov/gene/?term=10914 PAP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001698 10914 PAPOLA http://www.ncbi.nlm.nih.gov/gene/?term=10914 PAP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001699 10915 TCERG1 http://www.ncbi.nlm.nih.gov/gene/?term=10915 "CA150, TAF2S, Urn1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001700 10915 TCERG1 http://www.ncbi.nlm.nih.gov/gene/?term=10915 "CA150, TAF2S, Urn1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001701 109163 3010003L21Rik http://www.ncbi.nlm.nih.gov/gene/?term=109163 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001702 109181 Trip11 http://www.ncbi.nlm.nih.gov/gene/?term=109181 "2610511G22Rik, 3110031G15Rik, 6030460N08Rik, AI450776, GMAP-210, TRIP230 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001703 10919 EHMT2 http://www.ncbi.nlm.nih.gov/gene/?term=10919 "BAT8, C6orf30, G9A, GAT8, KMT1C, NG36 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001704 109202 A930024E05Rik http://www.ncbi.nlm.nih.gov/gene/?term=109202 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001705 10920 COPS8 http://www.ncbi.nlm.nih.gov/gene/?term=10920 "COP9, CSN8, SGN8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001706 10920 COPS8 http://www.ncbi.nlm.nih.gov/gene/?term=10920 "COP9, CSN8, SGN8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001707 10920 COPS8 http://www.ncbi.nlm.nih.gov/gene/?term=10920 "COP9, CSN8, SGN8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001708 10921 RNPS1 http://www.ncbi.nlm.nih.gov/gene/?term=10921 E5.1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001709 10921 RNPS1 http://www.ncbi.nlm.nih.gov/gene/?term=10921 E5.1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001710 10921 RNPS1 http://www.ncbi.nlm.nih.gov/gene/?term=10921 E5.1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001711 10922 FASTK http://www.ncbi.nlm.nih.gov/gene/?term=10922 FAST mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001712 10922 FASTK http://www.ncbi.nlm.nih.gov/gene/?term=10922 FAST mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001713 109232 Sccpdh http://www.ncbi.nlm.nih.gov/gene/?term=109232 "AW214504, C330023F11Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001714 109232 Sccpdh http://www.ncbi.nlm.nih.gov/gene/?term=109232 "AW214504, C330023F11Rik " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00001715 10923 SUB1 http://www.ncbi.nlm.nih.gov/gene/?term=10923 "P15, PC4, p14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001716 10923 SUB1 http://www.ncbi.nlm.nih.gov/gene/?term=10923 "P15, PC4, p14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001717 109242 Kif24 http://www.ncbi.nlm.nih.gov/gene/?term=109242 "4933425J19Rik, 9430029L23Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001718 10924 SMPDL3A http://www.ncbi.nlm.nih.gov/gene/?term=10924 "ASM3A, ASML3a, yR36GH4.1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001719 10924 SMPDL3A http://www.ncbi.nlm.nih.gov/gene/?term=10924 "ASM3A, ASML3a, yR36GH4.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001720 109270 Prr5 http://www.ncbi.nlm.nih.gov/gene/?term=109270 "AU043908, Arhgap8, C030017C09Rik, C78947, Protor-1, Protor1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001721 10927 SPIN1 http://www.ncbi.nlm.nih.gov/gene/?term=10927 "SPIN, TDRD24 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001722 109284 R3hdm4 http://www.ncbi.nlm.nih.gov/gene/?term=109284 "AI503502, C030046I01Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001723 10928 RALBP1 http://www.ncbi.nlm.nih.gov/gene/?term=10928 "RIP1, RLIP1, RLIP76 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001724 10928 RALBP1 http://www.ncbi.nlm.nih.gov/gene/?term=10928 "RIP1, RLIP1, RLIP76 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001725 10929 SRSF8 http://www.ncbi.nlm.nih.gov/gene/?term=10929 "DSM-1, SFRS2B, SRP46 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001726 109332 Cdcp1 http://www.ncbi.nlm.nih.gov/gene/?term=109332 "9030022E12Rik, AA409659, E030027H19Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001727 109333 Pkn2 http://www.ncbi.nlm.nih.gov/gene/?term=109333 "6030436C20Rik, AI507382, PRK2, Prkcl2, Stk7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001728 109346 Ankrd39 http://www.ncbi.nlm.nih.gov/gene/?term=109346 "9130416N05Rik, C030004B10Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001729 109359 Fam175b http://www.ncbi.nlm.nih.gov/gene/?term=109359 "AA589499, AI853413, Abro1, C430003P19Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001730 10935 PRDX3 http://www.ncbi.nlm.nih.gov/gene/?term=10935 "AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001731 10935 PRDX3 http://www.ncbi.nlm.nih.gov/gene/?term=10935 "AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001732 10935 PRDX3 http://www.ncbi.nlm.nih.gov/gene/?term=10935 "AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001733 10938 EHD1 http://www.ncbi.nlm.nih.gov/gene/?term=10938 "H-PAST, HPAST1, PAST, PAST1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001734 10939 AFG3L2 http://www.ncbi.nlm.nih.gov/gene/?term=10939 "SCA28, SPAX5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001735 10940 POP1 http://www.ncbi.nlm.nih.gov/gene/?term=10940 mRNA Homo sapiens 21854988 Mitochondrion - Next-generation sequencing "Firstly, to validate the two-phase sequencing approach, we considered three noncoding RNAs (ncRNAs), 5S rRNA, MRP and RNase P, that have been previously shown to be present in the mitochondrial matrix (Wang et al., 2010), finding all transcripts, though lowly expressed, enriched in mitoplasts (Figure S2D). " RLID00001736 10943 MSL3 http://www.ncbi.nlm.nih.gov/gene/?term=10943 MSL3L1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001737 10944 C11orf58 http://www.ncbi.nlm.nih.gov/gene/?term=10944 "IMAGE145052, SMAP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001738 10944 C11orf58 http://www.ncbi.nlm.nih.gov/gene/?term=10944 "IMAGE145052, SMAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001739 10945 KDELR1 http://www.ncbi.nlm.nih.gov/gene/?term=10945 "ERD2, ERD2.1, HDEL, PM23 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001740 10945 KDELR1 http://www.ncbi.nlm.nih.gov/gene/?term=10945 "ERD2, ERD2.1, HDEL, PM23 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001741 10945 KDELR1 http://www.ncbi.nlm.nih.gov/gene/?term=10945 "ERD2, ERD2.1, HDEL, PM23 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001742 10946 SF3A3 http://www.ncbi.nlm.nih.gov/gene/?term=10946 "PRP9, PRPF9, SAP61, SF3a60 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001743 10946 SF3A3 http://www.ncbi.nlm.nih.gov/gene/?term=10946 "PRP9, PRPF9, SAP61, SF3a60 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001744 10947 AP3M2 http://www.ncbi.nlm.nih.gov/gene/?term=10947 "AP47B, CLA20, P47B " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001745 10947 AP3M2 http://www.ncbi.nlm.nih.gov/gene/?term=10947 "AP47B, CLA20, P47B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001746 10948 STARD3 http://www.ncbi.nlm.nih.gov/gene/?term=10948 "CAB1, MLN64, es64 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001747 10949 HNRNPA0 http://www.ncbi.nlm.nih.gov/gene/?term=10949 HNRPA0 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001748 10950 BTG3 http://www.ncbi.nlm.nih.gov/gene/?term=10950 "ANA, TOB5, TOB55, TOFA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001749 10950 BTG3 http://www.ncbi.nlm.nih.gov/gene/?term=10950 "ANA, TOB5, TOB55, TOFA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001750 10950 BTG3 http://www.ncbi.nlm.nih.gov/gene/?term=10950 "ANA, TOB5, TOB55, TOFA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001751 10951 CBX1 http://www.ncbi.nlm.nih.gov/gene/?term=10951 "CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001752 10951 CBX1 http://www.ncbi.nlm.nih.gov/gene/?term=10951 "CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001753 10952 SEC61B http://www.ncbi.nlm.nih.gov/gene/?term=10952 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001754 10952 SEC61B http://www.ncbi.nlm.nih.gov/gene/?term=10952 mRNA Homo sapiens 26272916 Endoplasmic reticulum U2OS cell Fluorescence in situ hybridization "Next, we monitored the localization of nesprin-2 (SYNE2) mRNA, which encodes a giant tail-anchored protein (796 kDa) that is present on the outer nuclear envelope and is involved in nuclear positioning (Luxton et al., 2010). After extraction, about two thirds of the foci remained, indicating that some of this mRNA was anchored to the ER (Fig. 1A,B). To ensure that the FISH signal was specific, we also probed cells that were depleted of the endogenous nesprin-2 mRNA using RNA interference (RNAi). Indeed, small hairpin RNA (shRNA)-treated cells lost 90% of their signal (supplementary material Fig. S1), indicating that our nesprin-2 probes detected the intended target. Like Sec61b, nesprin-2 mRNA largely remained associated with the ER in cells treated with HHT, or puromycin and EDTA. Thus nesprin-2, like Sec61b, can associate with the ER membrane, and this activity is mostly independent of translation. " RLID00001755 10952 SEC61B http://www.ncbi.nlm.nih.gov/gene/?term=10952 mRNA Homo sapiens 26272916 Nucleus U2OS cell Fluorescence in situ hybridization "Fig. 5.The initial targeting of Sec61b mRNA to the ER is partially dependent on ribosomes and translation. (B) Quantification of the fluorescence intensities of mRNAs in the ER and nucleus of extracted cell. Sec61b mRNA can occur to a certain extent in the absence of translation, it is clearly enhanced in the presence of translating ribosomes. " RLID00001756 10952 SEC61B http://www.ncbi.nlm.nih.gov/gene/?term=10952 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001757 10952 SEC61B http://www.ncbi.nlm.nih.gov/gene/?term=10952 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001758 10953 TOMM34 http://www.ncbi.nlm.nih.gov/gene/?term=10953 "HTOM34P, TOM34, URCC3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001759 10953 TOMM34 http://www.ncbi.nlm.nih.gov/gene/?term=10953 "HTOM34P, TOM34, URCC3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001760 10953 TOMM34 http://www.ncbi.nlm.nih.gov/gene/?term=10953 "HTOM34P, TOM34, URCC3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001761 10954 PDIA5 http://www.ncbi.nlm.nih.gov/gene/?term=10954 PDIR mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001762 10955 SERINC3 http://www.ncbi.nlm.nih.gov/gene/?term=10955 "AIGP1, DIFF33, SBBI99, TDE, TDE1, TMS-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001763 10955 SERINC3 http://www.ncbi.nlm.nih.gov/gene/?term=10955 "AIGP1, DIFF33, SBBI99, TDE, TDE1, TMS-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001764 10956 OS9 http://www.ncbi.nlm.nih.gov/gene/?term=10956 "ERLEC2, OS-9 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001765 10956 OS9 http://www.ncbi.nlm.nih.gov/gene/?term=10956 "ERLEC2, OS-9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001766 10957 PNRC1 http://www.ncbi.nlm.nih.gov/gene/?term=10957 "B4-2, PNAS-145, PROL2, PRR2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001767 10957 PNRC1 http://www.ncbi.nlm.nih.gov/gene/?term=10957 "B4-2, PNAS-145, PROL2, PRR2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001768 109594 Lmo1 http://www.ncbi.nlm.nih.gov/gene/?term=109594 "Rbtn-1, Rbtn1, Ttg1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001769 10959 TMED2 http://www.ncbi.nlm.nih.gov/gene/?term=10959 "P24A, RNP24, p24, p24b1, p24beta1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001770 10959 TMED2 http://www.ncbi.nlm.nih.gov/gene/?term=10959 "P24A, RNP24, p24, p24b1, p24beta1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001771 10959 TMED2 http://www.ncbi.nlm.nih.gov/gene/?term=10959 "P24A, RNP24, p24, p24b1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001772 10960 LMAN2 http://www.ncbi.nlm.nih.gov/gene/?term=10960 "C5orf8, GP36B, VIP36 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001773 10961 ERP29 http://www.ncbi.nlm.nih.gov/gene/?term=10961 "C12orf8, ERp28, ERp31, HEL-S-107, PDI-DB, PDIA9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001774 10961 ERP29 http://www.ncbi.nlm.nih.gov/gene/?term=10961 "C12orf8, ERp28, ERp31, HEL-S-107, PDI-DB, PDIA9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001775 109624 Cald1 http://www.ncbi.nlm.nih.gov/gene/?term=109624 "4833423D12Rik, AI195384, AV071549, AW536160, C920027I18Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001776 10962 MLLT11 http://www.ncbi.nlm.nih.gov/gene/?term=10962 AF1Q mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001777 10963 STIP1 http://www.ncbi.nlm.nih.gov/gene/?term=10963 "HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001778 10963 STIP1 http://www.ncbi.nlm.nih.gov/gene/?term=10963 "HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001779 10963 STIP1 http://www.ncbi.nlm.nih.gov/gene/?term=10963 "HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001780 109652 Acy1 http://www.ncbi.nlm.nih.gov/gene/?term=109652 "1110014J22Rik, Acy-1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001781 10966 RAB40B http://www.ncbi.nlm.nih.gov/gene/?term=10966 "RAR, SEC4L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001782 10966 RAB40B http://www.ncbi.nlm.nih.gov/gene/?term=10966 "RAR, SEC4L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001783 109676 Ank2 http://www.ncbi.nlm.nih.gov/gene/?term=109676 "AI835472, AW491075, Ank-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001784 10969 EBNA1BP2 http://www.ncbi.nlm.nih.gov/gene/?term=10969 "EBP2, NOBP, P40 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001785 10969 EBNA1BP2 http://www.ncbi.nlm.nih.gov/gene/?term=10969 "EBP2, NOBP, P40 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001786 109700 Itga1 http://www.ncbi.nlm.nih.gov/gene/?term=109700 "CD49A, E130012M19Rik, Vla1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001787 10970 CKAP4 http://www.ncbi.nlm.nih.gov/gene/?term=10970 "CLIMP-63, ERGIC-63, p63 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001788 10970 CKAP4 http://www.ncbi.nlm.nih.gov/gene/?term=10970 "CLIMP-63, ERGIC-63, p63 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001789 109711 Actn1 http://www.ncbi.nlm.nih.gov/gene/?term=109711 "3110023F10Rika, Actn1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001790 10971 YWHAQ http://www.ncbi.nlm.nih.gov/gene/?term=10971 "14-3-3, 1C5, HS1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001791 10971 YWHAQ http://www.ncbi.nlm.nih.gov/gene/?term=10971 "14-3-3, 1C5, HS1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001792 10971 YWHAQ http://www.ncbi.nlm.nih.gov/gene/?term=10971 "14-3-3, 1C5, HS1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001793 10972 TMED10 http://www.ncbi.nlm.nih.gov/gene/?term=10972 "P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, p24d1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001794 10972 TMED10 http://www.ncbi.nlm.nih.gov/gene/?term=10972 "P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, p24d1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001795 10972 TMED10 http://www.ncbi.nlm.nih.gov/gene/?term=10972 "P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, p24d1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001796 10973 ASCC3 http://www.ncbi.nlm.nih.gov/gene/?term=10973 "ASC1p200, HELIC1, RNAH " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001797 10974 ADIRF http://www.ncbi.nlm.nih.gov/gene/?term=10974 "AFRO, APM2, C10orf116, apM-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001798 10974 ADIRF http://www.ncbi.nlm.nih.gov/gene/?term=10974 "AFRO, APM2, C10orf116, apM-2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001799 109754 Cyb5r3 http://www.ncbi.nlm.nih.gov/gene/?term=109754 "0610016L08Rik, 2500002N19Rik, C85115, Dia-1, Dia1, WU:AL591952.1-001, WU:AL591952.1-002, WU:AL591952.1-003, WU:Cyb5r3 " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00001800 10975 UQCR11 http://www.ncbi.nlm.nih.gov/gene/?term=10975 "0710008D09Rik, QCR10, UQCR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001801 109785 Pgm3 http://www.ncbi.nlm.nih.gov/gene/?term=109785 "2810473H05Rik, Agm1, BB187688, C77933, PAGM, Pgm-3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001802 10978 CLP1 http://www.ncbi.nlm.nih.gov/gene/?term=10978 "HEAB, hClp1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001803 10979 FERMT2 http://www.ncbi.nlm.nih.gov/gene/?term=10979 "KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001804 10979 FERMT2 http://www.ncbi.nlm.nih.gov/gene/?term=10979 "KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001805 10980 COPS6 http://www.ncbi.nlm.nih.gov/gene/?term=10980 "CSN6, MOV34-34KD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001806 10981 RAB32 http://www.ncbi.nlm.nih.gov/gene/?term=10981 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001807 10981 RAB32 http://www.ncbi.nlm.nih.gov/gene/?term=10981 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001808 10982 MAPRE2 http://www.ncbi.nlm.nih.gov/gene/?term=10982 "CSCSC2, EB1, EB2, RP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001809 10982 MAPRE2 http://www.ncbi.nlm.nih.gov/gene/?term=10982 "CSCSC2, EB1, EB2, RP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001810 10984 KCNQ1OT1 http://www.ncbi.nlm.nih.gov/gene/?term=10984 "KCNQ1-AS2, KCNQ10T1, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012 " lncRNA Homo sapiens 22193719 Nucleus Embryonic stem cell qRT-PCR|Microarray "Figure 7: Neuronal lncRNAs act via diverse mechanisms. (A) Quantification of relative expression of lncRNAs in nuclear and cytoplasmic cell fractions. (B) Quantification of changes in hosted miRNAs in response to lncRNA_N2 knockdown. MiRNAs were quantified using Taqman miRNA qPCR. (C-E) RIP of lncRNAs with SUZ12 and REST antibodies. The interaction of HOTAIR with SUZ12 is a known interaction that serves as a positive control (Gupta et al, 2010). * and ** indicate P-values of <0.05 and <0.01, respectively. Data are collected from Figure 7. " RLID00001811 10984 KCNQ1OT1 http://www.ncbi.nlm.nih.gov/gene/?term=10984 "KCNQ1-AS2, KCNQ10T1, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012 " lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00001812 109857 Cbr3 http://www.ncbi.nlm.nih.gov/gene/?term=109857 "1110001J05Rik, C81353 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001813 10985 GCN1 http://www.ncbi.nlm.nih.gov/gene/?term=10985 "GCN1LL1, PRIC295, GCN1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001814 10985 GCN1 http://www.ncbi.nlm.nih.gov/gene/?term=10985 "GCN1LL1, PRIC295, GCN1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001815 10985 GCN1 http://www.ncbi.nlm.nih.gov/gene/?term=10985 "GCN1L, GCN1L1, PRIC295 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001816 10987 COPS5 http://www.ncbi.nlm.nih.gov/gene/?term=10987 "CSN5, JAB1, MOV-34, SGN5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001817 10987 COPS5 http://www.ncbi.nlm.nih.gov/gene/?term=10987 "CSN5, JAB1, MOV-34, SGN5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001818 10987 COPS5 http://www.ncbi.nlm.nih.gov/gene/?term=10987 "CSN5, JAB1, MOV-34, SGN5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001819 109880 Braf http://www.ncbi.nlm.nih.gov/gene/?term=109880 "9930012E13Rik, AA120551, AA387315, AA473386, B-raf-2, Braf2, C230098H17, C87398, D6Ertd631e, Braf " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001820 10988 METAP2 http://www.ncbi.nlm.nih.gov/gene/?term=10988 "MAP2, MNPEP, p67eIF2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001821 10988 METAP2 http://www.ncbi.nlm.nih.gov/gene/?term=10988 "MAP2, MNPEP, p67eIF2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001822 10988 METAP2 http://www.ncbi.nlm.nih.gov/gene/?term=10988 "MAP2, MNPEP, p67eIF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001823 10989 IMMT http://www.ncbi.nlm.nih.gov/gene/?term=10989 "HMP, MINOS2, Mic60, P87, P87/89, P89, PIG4, PIG52 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001824 10989 IMMT http://www.ncbi.nlm.nih.gov/gene/?term=10989 "HMP, MINOS2, Mic60, P87, P87/89, P89, PIG4, PIG52 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001825 109900 Asl http://www.ncbi.nlm.nih.gov/gene/?term=109900 2510006M18Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001826 109910 Zfp91 http://www.ncbi.nlm.nih.gov/gene/?term=109910 "9130014I08Rik, A530054C17Rik, AL024263, AW545902, Pzf, Zfp-91 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001827 10992 SF3B2 http://www.ncbi.nlm.nih.gov/gene/?term=10992 "Cus1, SAP145, SF3B145, SF3b1, SF3b150 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001828 10992 SF3B2 http://www.ncbi.nlm.nih.gov/gene/?term=10992 "Cus1, SAP145, SF3B145, SF3b1, SF3b150 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001829 10994 ILVBL http://www.ncbi.nlm.nih.gov/gene/?term=10994 "209L8, AHAS, ILV2H " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001830 10994 ILVBL http://www.ncbi.nlm.nih.gov/gene/?term=10994 "209L8, AHAS, ILV2H " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001831 10998 SLC27A5 http://www.ncbi.nlm.nih.gov/gene/?term=10998 "ACSB, ACSVL6, BACS, BAL, FACVL3, FATP-5, FATP5, VLACSR, VLCS-H2, VLCSH2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001832 10998 SLC27A5 http://www.ncbi.nlm.nih.gov/gene/?term=10998 "ACSB, ACSVL6, BACS, BAL, FACVL3, FATP-5, FATP5, VLACSR, VLCS-H2, VLCSH2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001833 10999 SLC27A4 http://www.ncbi.nlm.nih.gov/gene/?term=10999 "ACSVL4, FATP4, IPS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001834 109 ADCY3 http://www.ncbi.nlm.nih.gov/gene/?term=109 "AC-III, AC3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001835 109 ADCY3 http://www.ncbi.nlm.nih.gov/gene/?term=109 "AC-III, AC3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001836 11001 SLC27A2 http://www.ncbi.nlm.nih.gov/gene/?term=11001 "ACSVL1, FACVL1, FATP2, HsT17226, VLACS, VLCS, hFACVL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001837 11004 KIF2C http://www.ncbi.nlm.nih.gov/gene/?term=11004 "CT139, KNSL6, MCAK " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001838 11004 KIF2C http://www.ncbi.nlm.nih.gov/gene/?term=11004 "CT139, KNSL6, MCAK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001839 11004 KIF2C http://www.ncbi.nlm.nih.gov/gene/?term=11004 "CT139, KNSL6, MCAK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001840 11005 SPINK5 http://www.ncbi.nlm.nih.gov/gene/?term=11005 "LEKTI, LETKI, NETS, NS, VAKTI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001841 11007 CCDC85B http://www.ncbi.nlm.nih.gov/gene/?term=11007 DIPA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001842 11007 CCDC85B http://www.ncbi.nlm.nih.gov/gene/?term=11007 DIPA mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001843 11009 IL24 http://www.ncbi.nlm.nih.gov/gene/?term=11009 "C49A, FISP, IL10B, MDA7, MOB5, ST16 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001844 11010 GLIPR1 http://www.ncbi.nlm.nih.gov/gene/?term=11010 "CRISP7, GLIPR, RTVP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001845 11011 TLK2 http://www.ncbi.nlm.nih.gov/gene/?term=11011 "HsHPK, PKU-ALPHA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001846 110135 Fgb http://www.ncbi.nlm.nih.gov/gene/?term=110135 2510049G14Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001847 11014 KDELR2 http://www.ncbi.nlm.nih.gov/gene/?term=11014 "ELP-1, ERD2.2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001848 11014 KDELR2 http://www.ncbi.nlm.nih.gov/gene/?term=11014 "ELP-1, ERD2.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001849 110157 Raf1 http://www.ncbi.nlm.nih.gov/gene/?term=110157 "6430402F14Rik, AA990557, BB129353, Craf1, D830050J10Rik, Raf-1, c-Raf, v-Raf " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001850 11015 KDELR3 http://www.ncbi.nlm.nih.gov/gene/?term=11015 ERD2L3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001851 11015 KDELR3 http://www.ncbi.nlm.nih.gov/gene/?term=11015 ERD2L3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001852 11016 ATF7 http://www.ncbi.nlm.nih.gov/gene/?term=11016 ATFA mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001853 110175 Ggct http://www.ncbi.nlm.nih.gov/gene/?term=110175 "A030007L17Rik, AA673177, Gctg, Ggc " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001854 11017 SNRNP27 http://www.ncbi.nlm.nih.gov/gene/?term=11017 "27K, RY1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001855 11017 SNRNP27 http://www.ncbi.nlm.nih.gov/gene/?term=11017 "27K, RY1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001856 11018 TMED1 http://www.ncbi.nlm.nih.gov/gene/?term=11018 "IL1RL1LG, Il1rl1l, Tp24, p24g1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001857 110198 Akr7a5 http://www.ncbi.nlm.nih.gov/gene/?term=110198 "0610025K21Rik, Afar, Afar1, Akr7a2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001858 11019 LIAS http://www.ncbi.nlm.nih.gov/gene/?term=11019 "HGCLAS, HUSSY-01, LAS, LIP1, LS, PDHLD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001859 11019 LIAS http://www.ncbi.nlm.nih.gov/gene/?term=11019 "HUSSY-01, LAS, LIP1, LS, PDHLD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001860 11020 IFT27 http://www.ncbi.nlm.nih.gov/gene/?term=11020 "BBS19, RABL4, RAYL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001861 11021 RAB35 http://www.ncbi.nlm.nih.gov/gene/?term=11021 "H-ray, RAB1C, RAY " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001862 11021 RAB35 http://www.ncbi.nlm.nih.gov/gene/?term=11021 "H-ray, RAB1C, RAY " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001863 11025 LILRB3 http://www.ncbi.nlm.nih.gov/gene/?term=11025 "CD85A, HL9, ILT-5, ILT5, LILRA6, LIR-3, LIR3, PIR-B, PIRB " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001864 11025 LILRB3 http://www.ncbi.nlm.nih.gov/gene/?term=11025 "CD85A, HL9, ILT-5, ILT5, LILRA6, LIR-3, LIR3, PIR-B, PIRB " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001865 11025 LILRB3 http://www.ncbi.nlm.nih.gov/gene/?term=11025 "CD85A, HL9, ILT-5, ILT5, LILRA6, LIR-3, LIR3, PIRB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001866 11027 LILRA2 http://www.ncbi.nlm.nih.gov/gene/?term=11027 "CD85H, ILT1, LIR-7, LIR7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001867 1102 RCBTB2 http://www.ncbi.nlm.nih.gov/gene/?term=1102 "CHC1L, RLG " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001868 11031 RAB31 http://www.ncbi.nlm.nih.gov/gene/?term=11031 Rab22B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001869 110326 Tas1r1 http://www.ncbi.nlm.nih.gov/gene/?term=110326 "Gpr70, T1r1, TR1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001870 110333 Rmst http://www.ncbi.nlm.nih.gov/gene/?term=110333 "AI853140, C230053E11Rik, D930049J19Rik, Dmt2, M2, Ncrms " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001871 110333 Rmst http://www.ncbi.nlm.nih.gov/gene/?term=110333 "AI853140, C230053E11Rik, D930049J19Rik, Dmt2, M2, Ncrms " lncRNA Mus musculus 26464439 Axon Motoneuron In situ hybridization|qRT-PCR "We then analyzed the abundance of several lncRNAs, namely Malat1, Meg3, Rmst, Xist and Miat. All of these lncRNAs were present in the axonal compartment. " RLID00001872 11033 ADAP1 http://www.ncbi.nlm.nih.gov/gene/?term=11033 "CENTA1, GCS1L, p42IP4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001873 11034 DSTN http://www.ncbi.nlm.nih.gov/gene/?term=11034 "ACTDP, ADF, HEL32, bA462D18.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001874 110350 Dync2h1 http://www.ncbi.nlm.nih.gov/gene/?term=110350 "4432416O06Rik, AI448217, D030010H02Rik, D330044F14Rik, DHC1b, DHC2, Dnchc2, b2b414Clo, mKIAA1997 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001875 11037 STON1 http://www.ncbi.nlm.nih.gov/gene/?term=11037 "SALF, SBLF, STN1, STNB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001876 11039 SMA4 http://www.ncbi.nlm.nih.gov/gene/?term=11039 "SMA3, b55C20.2 " lncRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001877 11040 PIM2 http://www.ncbi.nlm.nih.gov/gene/?term=11040 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001878 11040 PIM2 http://www.ncbi.nlm.nih.gov/gene/?term=11040 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001879 11040 PIM2 http://www.ncbi.nlm.nih.gov/gene/?term=11040 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001880 11044 PAPD7 http://www.ncbi.nlm.nih.gov/gene/?term=11044 "LAK-1, LAK1, POLK, POLS, TRF4, TRF4-1, TRF41, TUTASE5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001881 11046 SLC35D2 http://www.ncbi.nlm.nih.gov/gene/?term=11046 "HFRC1, SQV7L, UGTrel8, hfrc " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001882 11046 SLC35D2 http://www.ncbi.nlm.nih.gov/gene/?term=11046 "HFRC1, SQV7L, UGTrel8, hfrc " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001883 11047 ADRM1 http://www.ncbi.nlm.nih.gov/gene/?term=11047 "ARM-1, ARM1, GP110 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001884 11047 ADRM1 http://www.ncbi.nlm.nih.gov/gene/?term=11047 "ARM-1, ARM1, GP110 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001885 11047 ADRM1 http://www.ncbi.nlm.nih.gov/gene/?term=11047 "ARM-1, ARM1, GP110 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001886 11049 NUS1P3 http://www.ncbi.nlm.nih.gov/gene/?term=11049 YDD19 lncRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001887 1104 RCC1 http://www.ncbi.nlm.nih.gov/gene/?term=1104 "CHC1-I, SNHG3-RCC1, RCC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001888 1104 RCC1 http://www.ncbi.nlm.nih.gov/gene/?term=1104 "CHC1-I, SNHG3-RCC1, RCC1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001889 1104 RCC1 http://www.ncbi.nlm.nih.gov/gene/?term=1104 "CHC1, RCC1-I, SNHG3-RCC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001890 11051 NUDT21 http://www.ncbi.nlm.nih.gov/gene/?term=11051 "CFIM25, CPSF5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001891 11051 NUDT21 http://www.ncbi.nlm.nih.gov/gene/?term=11051 "CFIM25, CPSF5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001892 110524 Dgkq http://www.ncbi.nlm.nih.gov/gene/?term=110524 "110kDa, DAGK, DAGK7, Dagk4, Dgkd " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001893 11052 CPSF6 http://www.ncbi.nlm.nih.gov/gene/?term=11052 "CFIM, CFIM68, HPBRII-4, HPBRII-7 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001894 11052 CPSF6 http://www.ncbi.nlm.nih.gov/gene/?term=11052 "CFIM, CFIM68, HPBRII-4, HPBRII-7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001895 110532 Adarb1 http://www.ncbi.nlm.nih.gov/gene/?term=110532 "1700057H01Rik, AW124433, AW558573, Adar2, BB220382, D10Bwg0447e, Red1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001896 110542 Amhr2 http://www.ncbi.nlm.nih.gov/gene/?term=110542 "Misiir, Misrii, Mrii " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001897 11054 OGFR http://www.ncbi.nlm.nih.gov/gene/?term=11054 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001898 11056 DDX52 http://www.ncbi.nlm.nih.gov/gene/?term=11056 "HUSSY19, ROK1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001899 11057 ABHD2 http://www.ncbi.nlm.nih.gov/gene/?term=11057 "HS1-2, LABH2, PHPS1-2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001900 11057 ABHD2 http://www.ncbi.nlm.nih.gov/gene/?term=11057 "HS1-2, LABH2, PHPS1-2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001901 11059 WWP1 http://www.ncbi.nlm.nih.gov/gene/?term=11059 "AIP5, Tiul1, hSDRP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001902 1105 CHD1 http://www.ncbi.nlm.nih.gov/gene/?term=1105 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001903 1105 CHD1 http://www.ncbi.nlm.nih.gov/gene/?term=1105 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001904 11060 WWP2 http://www.ncbi.nlm.nih.gov/gene/?term=11060 "AIP2, WWp2-like " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001905 11060 WWP2 http://www.ncbi.nlm.nih.gov/gene/?term=11060 "AIP2, WWp2-like " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001906 110611 Hdlbp http://www.ncbi.nlm.nih.gov/gene/?term=110611 "1110005P14Rik, AA960365, AI118566, D1Ertd101e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001907 110616 Atxn3 http://www.ncbi.nlm.nih.gov/gene/?term=110616 "2210008M02Rik, AI463012, AI647473, ATX3, MJD1, Mjd, Sca3, ataxin-3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001908 11062 DUS4L http://www.ncbi.nlm.nih.gov/gene/?term=11062 "DUS4, PP35 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001909 11063 SOX30 http://www.ncbi.nlm.nih.gov/gene/?term=11063 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001910 110651 Rps6ka3 http://www.ncbi.nlm.nih.gov/gene/?term=110651 "MAPKAPK-1b, MPK-9, Rsk2, S6K-alpha3, p90RSK3, pp90RSK2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001911 11066 SNRNP35 http://www.ncbi.nlm.nih.gov/gene/?term=11066 "HM-1, U1SNRNPBP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001912 11066 SNRNP35 http://www.ncbi.nlm.nih.gov/gene/?term=11066 "HM-1, U1SNRNPBP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001913 11067 C10orf10 http://www.ncbi.nlm.nih.gov/gene/?term=11067 "DEPP, FIG, Fseg " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001914 11067 C10orf10 http://www.ncbi.nlm.nih.gov/gene/?term=11067 "DEPP, FIG, Fseg " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001915 11068 CYB561D2 http://www.ncbi.nlm.nih.gov/gene/?term=11068 "101F6, TSP10, XXcos-LUCA11.4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001916 11068 CYB561D2 http://www.ncbi.nlm.nih.gov/gene/?term=11068 "101F6, TSP10, XXcos-LUCA11.4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001917 1106 CHD2 http://www.ncbi.nlm.nih.gov/gene/?term=1106 EEOC mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001918 1106 CHD2 http://www.ncbi.nlm.nih.gov/gene/?term=1106 EEOC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001919 11070 TMEM115 http://www.ncbi.nlm.nih.gov/gene/?term=11070 PL6 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001920 11070 TMEM115 http://www.ncbi.nlm.nih.gov/gene/?term=11070 PL6 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001921 11072 DUSP14 http://www.ncbi.nlm.nih.gov/gene/?term=11072 "MKP-L, MKP6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001922 11073 TOPBP1 http://www.ncbi.nlm.nih.gov/gene/?term=11073 TOP2BP1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001923 11074 TRIM31 http://www.ncbi.nlm.nih.gov/gene/?term=11074 "C6orf13, HCG1, HCGI, RNF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001924 110750 Cse1l http://www.ncbi.nlm.nih.gov/gene/?term=110750 "2610100P18Rik, AA407533, Capts, Cas, Xpo2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001925 11076 TPPP http://www.ncbi.nlm.nih.gov/gene/?term=11076 "TPPP/p25, TPPP1, p24, p25, p25alpha " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001926 11078 TRIOBP http://www.ncbi.nlm.nih.gov/gene/?term=11078 "DFNB28, HRIHFB2122, TAP68, TARA, dJ37E16.4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001927 11078 TRIOBP http://www.ncbi.nlm.nih.gov/gene/?term=11078 "DFNB28, HRIHFB2122, TAP68, TARA, dJ37E16.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001928 11079 RER1 http://www.ncbi.nlm.nih.gov/gene/?term=11079 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001929 11079 RER1 http://www.ncbi.nlm.nih.gov/gene/?term=11079 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001930 11079 RER1 http://www.ncbi.nlm.nih.gov/gene/?term=11079 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001931 1107 CHD3 http://www.ncbi.nlm.nih.gov/gene/?term=1107 "Mi-2a, Mi2-ALPHA, ZFH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001932 110809 Srsf1 http://www.ncbi.nlm.nih.gov/gene/?term=110809 "1110054N12Rik, 5730507C05Rik, 6330415C05Rik, AI482334, AW491331, Asf, Sf2, Sfrs1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001933 110834 Chrna3 http://www.ncbi.nlm.nih.gov/gene/?term=110834 "(a)3, A730007P14Rik, Acra-3, Acra3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001934 11083 DIDO1 http://www.ncbi.nlm.nih.gov/gene/?term=11083 "BYE1, C20orf158, DATF-1, DATF1, DIDO2, DIDO3, DIO-1, DIO1, dJ885L7.8 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001935 11083 DIDO1 http://www.ncbi.nlm.nih.gov/gene/?term=11083 "BYE1, C20orf158, DATF-1, DATF1, DIDO2, DIDO3, DIO-1, DIO1, dJ885L7.8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001936 110842 Etfa http://www.ncbi.nlm.nih.gov/gene/?term=110842 "2010200I21Rik, D9Ertd394e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001937 110876 Scn2a1 http://www.ncbi.nlm.nih.gov/gene/?term=110876 "6430408L10, A230052E19Rik, Nav1.2, Scn2a " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001938 110877 Slc18a1 http://www.ncbi.nlm.nih.gov/gene/?term=110877 "4832416I10Rik, Vat1, Vmat1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001939 110886 Gabra5 http://www.ncbi.nlm.nih.gov/gene/?term=110886 A230018I05Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001940 110893 Slc8a3 http://www.ncbi.nlm.nih.gov/gene/?term=110893 "AW742262, Ncx3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001941 1108 CHD4 http://www.ncbi.nlm.nih.gov/gene/?term=1108 "CHD-4, Mi-2b, Mi2-BETA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001942 1108 CHD4 http://www.ncbi.nlm.nih.gov/gene/?term=1108 "CHD-4, Mi-2b, Mi2-BETA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001943 11091 WDR5 http://www.ncbi.nlm.nih.gov/gene/?term=11091 "BIG-3, CFAP89, SWD3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001944 110920 Hspa13 http://www.ncbi.nlm.nih.gov/gene/?term=110920 "1600002I10Rik, AV006182, B230217N24Rik, Stch " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001945 110924 Tmevp3 http://www.ncbi.nlm.nih.gov/gene/?term=110924 NeST lncRNA Mus musculus 23415224 Nucleus T cell RT-PCR "We hypothesized that, like several lncRNAs, NeST RNA affects IFN-γ accumulation at the transcriptional level by interacting with chromatin modification complexes. Consistent with this idea, most of the NeST RNA in either congenic or transgenic mice was found in the nuclear fraction of CD8+ T cells, co-fractionating with unspliced, but not spliced, actin mRNA (Fig. 6A). " RLID00001946 11094 CACFD1 http://www.ncbi.nlm.nih.gov/gene/?term=11094 "C9orf7, D9S2135, FLOWER " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001947 110954 Rpl10 http://www.ncbi.nlm.nih.gov/gene/?term=110954 "D0HXS648, DXHXS648, DXHXS648E, QM, QM16 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00001948 110956 D17H6S56E-5 http://www.ncbi.nlm.nih.gov/gene/?term=110956 G7e mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001949 110960 Tars http://www.ncbi.nlm.nih.gov/gene/?term=110960 "D15Wsu59e, ThrRS " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001950 11096 ADAMTS5 http://www.ncbi.nlm.nih.gov/gene/?term=11096 "ADAM-TS 11, ADAM-TS 5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001951 11097 NUPL2 http://www.ncbi.nlm.nih.gov/gene/?term=11097 "CG1, NLP-1, NLP_1, hCG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001952 110989 Rnu1-ps1 http://www.ncbi.nlm.nih.gov/gene/110989 Rnu1-1 snRNA Mus musculus 26195734 Nucleus Fibroblast Sticky-Flare Synthesis "Furthermore, we investigate the application of Sticky-flares for tracking transcripts that undergo more extensive compartmentalization by fluorophore-labeling U1 small nuclear RNA and observing its distribution in the nucleus of live cells. " RLID00001953 11098 PRSS23 http://www.ncbi.nlm.nih.gov/gene/?term=11098 "SIG13, SPUVE, ZSIG13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001954 11098 PRSS23 http://www.ncbi.nlm.nih.gov/gene/?term=11098 "SIG13, SPUVE, ZSIG13 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001955 11098 PRSS23 http://www.ncbi.nlm.nih.gov/gene/?term=11098 "SIG13, SPUVE, ZSIG13 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001956 11100 HNRNPUL1 http://www.ncbi.nlm.nih.gov/gene/?term=11100 "E1B-AP5, E1BAP5, HNRPUL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001957 11101 ATE1 http://www.ncbi.nlm.nih.gov/gene/?term=11101 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001958 11102 RPP14 http://www.ncbi.nlm.nih.gov/gene/?term=11102 P14 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001959 11103 KRR1 http://www.ncbi.nlm.nih.gov/gene/?term=11103 "HRB2, RIP-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001960 11103 KRR1 http://www.ncbi.nlm.nih.gov/gene/?term=11103 "HRB2, RIP-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001961 11104 KATNA1 http://www.ncbi.nlm.nih.gov/gene/?term=11104 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001962 11104 KATNA1 http://www.ncbi.nlm.nih.gov/gene/?term=11104 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001963 11112 HIBADH http://www.ncbi.nlm.nih.gov/gene/?term=11112 NS5ATP1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001964 11112 HIBADH http://www.ncbi.nlm.nih.gov/gene/?term=11112 NS5ATP1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001965 11113 CIT http://www.ncbi.nlm.nih.gov/gene/?term=11113 "CRIK, STK21 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001966 11113 CIT http://www.ncbi.nlm.nih.gov/gene/?term=11113 "CRIK, STK21 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001967 11116 FGFR1OP http://www.ncbi.nlm.nih.gov/gene/?term=11116 FOP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001968 111173 Erc1 http://www.ncbi.nlm.nih.gov/gene/?term=111173 "4930404L01Rik, 5033405M01Rik, 9630025C19Rik, B430107L16Rik, CAST2, ELKS, Elks1, RAB6IP2A, RAB6IP2B, Rab6ip2, mKIAA1081 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00001969 11117 EMILIN1 http://www.ncbi.nlm.nih.gov/gene/?term=11117 "EMI, EMILIN, gp115 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001970 11118 BTN3A2 http://www.ncbi.nlm.nih.gov/gene/?term=11118 "BT3.2, BTF4, BTN3.2, CD277 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001971 11119 BTN3A1 http://www.ncbi.nlm.nih.gov/gene/?term=11119 "BT3.1, BTF5, BTN3.1, CD277 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001972 11119 BTN3A1 http://www.ncbi.nlm.nih.gov/gene/?term=11119 "BT3.1, BTF5, BTN3.1, CD277 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001973 11119 BTN3A1 http://www.ncbi.nlm.nih.gov/gene/?term=11119 "BT3.1, BTF5, BTN3.1, CD277 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001974 1111 CHEK1 http://www.ncbi.nlm.nih.gov/gene/?term=1111 CHK1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001975 1111 CHEK1 http://www.ncbi.nlm.nih.gov/gene/?term=1111 CHK1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001976 11120 BTN2A1 http://www.ncbi.nlm.nih.gov/gene/?term=11120 "BK14H9.1, BT2.1, BTF1, BTN2.1, DJ3E1.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001977 11124 FAF1 http://www.ncbi.nlm.nih.gov/gene/?term=11124 "CGI-03, HFAF1s, UBXD12, UBXN3A, hFAF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001978 11124 FAF1 http://www.ncbi.nlm.nih.gov/gene/?term=11124 "CGI-03, HFAF1s, UBXD12, UBXN3A, hFAF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001979 11127 KIF3A http://www.ncbi.nlm.nih.gov/gene/?term=11127 "FLA10, KLP-20 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001980 11127 KIF3A http://www.ncbi.nlm.nih.gov/gene/?term=11127 "FLA10, KLP-20 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001981 11127 KIF3A http://www.ncbi.nlm.nih.gov/gene/?term=11127 "FLA10, KLP-20 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001982 11128 POLR3A http://www.ncbi.nlm.nih.gov/gene/?term=11128 "ADDH, HLD7, RPC1, RPC155, hRPC155 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001983 1112 FOXN3 http://www.ncbi.nlm.nih.gov/gene/?term=1112 "C14orf116, CHES1, PRO1635 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001984 11130 ZWINT http://www.ncbi.nlm.nih.gov/gene/?term=11130 "HZwint-1, KNTC2AP, SIP301, ZWINT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001985 11130 ZWINT http://www.ncbi.nlm.nih.gov/gene/?term=11130 "HZwint-1, KNTC2AP, SIP30, ZWINT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001986 111357 Rsp6 http://www.ncbi.nlm.nih.gov/gene/?term=111357 Rsp-6 mRNA Mus musculus 25301173 Dendrite Hippocampus In situ hybridization "Figure 2: In situ hybridization reveals species-specific patterns of localization in neuronal dendrites. Fluorescent Microscopy evaluation of biotin-conjugated oligoprobes on paraformaldehyde fixed 14-day cultured rat and mouse cortical neurons hybridized with nine biotin-conjugated oligoprobes detected with streptadivin-Alexa Fluor 568 (Invitrogen). For each probe images set, the small bottom left corner panels represent MAP2 immuno-staining. Scale bar = 20um. (A), Probes against SFRS16, ARHGDIA and HNRPK transcripts show higher dendritic localization in mouse neurons than in rat neurons (Red box). (B), Probes against ZFP410, COMMD3 and RSP6 transcripts show higher dendritic localization in rat neurons than in mouse neurons (Blue box). (C), Probes against UBA52, OLFM1 and H2AFZ transcripts show high dendritic localization in both rat and mouse neurons (Black box). Data are collected from Figure 2. " RLID00001987 11135 CDC42EP1 http://www.ncbi.nlm.nih.gov/gene/?term=11135 "BORG5, CEP1, MSE55 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001988 11135 CDC42EP1 http://www.ncbi.nlm.nih.gov/gene/?term=11135 "BORG5, CEP1, MSE55 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001989 11137 PWP1 http://www.ncbi.nlm.nih.gov/gene/?term=11137 IEF-SSP-9502 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001990 11137 PWP1 http://www.ncbi.nlm.nih.gov/gene/?term=11137 IEF-SSP-9502 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001991 11138 TBC1D8 http://www.ncbi.nlm.nih.gov/gene/?term=11138 "AD3, GRAMD8, HBLP1A, VRP, TBC1D8 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001992 11140 CDC37 http://www.ncbi.nlm.nih.gov/gene/?term=11140 P50CDC37 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001993 11140 CDC37 http://www.ncbi.nlm.nih.gov/gene/?term=11140 P50CDC37 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00001994 11140 CDC37 http://www.ncbi.nlm.nih.gov/gene/?term=11140 P50CDC37 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001995 11142 PKIG http://www.ncbi.nlm.nih.gov/gene/?term=11142 PKI-gamma mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00001996 11143 KAT7 http://www.ncbi.nlm.nih.gov/gene/?term=11143 "HBO1, HBOA, MYST2, ZC2HC7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001997 11145 PLA2G16 http://www.ncbi.nlm.nih.gov/gene/?term=11145 "AdPLA, H-REV107-1, HRASLS3, HREV107, HREV107-1, HREV107-3, HRSL3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00001998 11149 BVES http://www.ncbi.nlm.nih.gov/gene/?term=11149 "HBVES, LGMD2X, POP1, POPDC1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00001999 11149 BVES http://www.ncbi.nlm.nih.gov/gene/?term=11149 "HBVES, LGMD2X, POP1, POPDC1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002000 11151 CORO1A http://www.ncbi.nlm.nih.gov/gene/?term=11151 "CLABP, CLIPINA, HCORO1, IMD8, TACO, p57 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002001 11152 WDR45 http://www.ncbi.nlm.nih.gov/gene/?term=11152 "JM5, NBIA4, NBIA5, WDRX1, WIPI-4, WIPI4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002002 11152 WDR45 http://www.ncbi.nlm.nih.gov/gene/?term=11152 "JM5, NBIA4, NBIA5, WDRX1, WIPI-4, WIPI4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002003 11154 AP4S1 http://www.ncbi.nlm.nih.gov/gene/?term=11154 "AP47B, CLA20, CLAPS4, CPSQ6, SPG52 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002004 11156 PTP4A3 http://www.ncbi.nlm.nih.gov/gene/?term=11156 "PRL-3, PRL-R, PRL3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002005 11157 LSM6 http://www.ncbi.nlm.nih.gov/gene/?term=11157 YDR378C mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002006 11158 RABL2B http://www.ncbi.nlm.nih.gov/gene/?term=11158 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002007 11158 RABL2B http://www.ncbi.nlm.nih.gov/gene/?term=11158 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002008 11158 RABL2B http://www.ncbi.nlm.nih.gov/gene/?term=11158 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002009 11159 RABL2A http://www.ncbi.nlm.nih.gov/gene/?term=11159 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002010 11159 RABL2A http://www.ncbi.nlm.nih.gov/gene/?term=11159 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002011 11160 ERLIN2 http://www.ncbi.nlm.nih.gov/gene/?term=11160 "C8orf2, Erlin-2, NET32, SPFH2, SPG18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002012 11160 ERLIN2 http://www.ncbi.nlm.nih.gov/gene/?term=11160 "C8orf2, Erlin-2, NET32, SPFH2, SPG18 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002013 11161 C14orf1 http://www.ncbi.nlm.nih.gov/gene/?term=11161 "ERG28, NET51 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002014 11162 NUDT6 http://www.ncbi.nlm.nih.gov/gene/?term=11162 "ASFGF2, FGF-AS, FGF2AS, GFG-1, GFG1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002015 11162 NUDT6 http://www.ncbi.nlm.nih.gov/gene/?term=11162 "ASFGF2, FGF-AS, FGF2AS, GFG-1, GFG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002016 11163 NUDT4 http://www.ncbi.nlm.nih.gov/gene/?term=11163 "DIPP2, DIPP2alpha, DIPP2beta, HDCMB47P " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002017 11164 NUDT5 http://www.ncbi.nlm.nih.gov/gene/?term=11164 "YSA1, YSA1H, YSAH1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002018 11165 NUDT3 http://www.ncbi.nlm.nih.gov/gene/?term=11165 "DIPP, DIPP-1, DIPP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002019 11165 NUDT3 http://www.ncbi.nlm.nih.gov/gene/?term=11165 "DIPP, DIPP-1, DIPP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002020 11167 FSTL1 http://www.ncbi.nlm.nih.gov/gene/?term=11167 "FRP, FSL1, MIR198 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002021 11168 PSIP1 http://www.ncbi.nlm.nih.gov/gene/?term=11168 "DFS70, LEDGF, PAIP, PSIP2, p52, p75 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002022 1116 CHI3L1 http://www.ncbi.nlm.nih.gov/gene/?term=1116 "ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YKL-40, YKL40, YYL-40, hCGP-39 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002023 11171 STRAP http://www.ncbi.nlm.nih.gov/gene/?term=11171 "MAWD, PT-WD, UNRIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002024 11174 ADAMTS6 http://www.ncbi.nlm.nih.gov/gene/?term=11174 "ADAM-TS 6, ADAM-TS6, ADAMTS-6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002025 11177 BAZ1A http://www.ncbi.nlm.nih.gov/gene/?term=11177 "ACF1, WALp1, WCRF180, hACF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002026 11178 LZTS1 http://www.ncbi.nlm.nih.gov/gene/?term=11178 "F37, FEZ1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002027 11178 LZTS1 http://www.ncbi.nlm.nih.gov/gene/?term=11178 "F37, FEZ1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002028 11178 LZTS1 http://www.ncbi.nlm.nih.gov/gene/?term=11178 "F37, FEZ1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002029 11180 WDR6 http://www.ncbi.nlm.nih.gov/gene/?term=11180 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002030 11180 WDR6 http://www.ncbi.nlm.nih.gov/gene/?term=11180 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002031 11180 WDR6 http://www.ncbi.nlm.nih.gov/gene/?term=11180 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002032 11181 TREH http://www.ncbi.nlm.nih.gov/gene/?term=11181 "TRE, TREA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002033 11182 SLC2A6 http://www.ncbi.nlm.nih.gov/gene/?term=11182 "GLUT6, GLUT9, HSA011372 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002034 11184 MAP4K1 http://www.ncbi.nlm.nih.gov/gene/?term=11184 HPK1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002035 11184 MAP4K1 http://www.ncbi.nlm.nih.gov/gene/?term=11184 HPK1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002036 11185 INMT http://www.ncbi.nlm.nih.gov/gene/?term=11185 TEMT mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002037 11185 INMT http://www.ncbi.nlm.nih.gov/gene/?term=11185 TEMT mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002038 11186 RASSF1 http://www.ncbi.nlm.nih.gov/gene/?term=11186 "123F2, NORE2AA, RDA32, REH3P21, RASSF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002039 11187 PKP3 http://www.ncbi.nlm.nih.gov/gene/?term=11187 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002040 11188 NISCH http://www.ncbi.nlm.nih.gov/gene/?term=11188 "I-1, IR1, IRAS, hIRAS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002041 11190 CEP250 http://www.ncbi.nlm.nih.gov/gene/?term=11190 "C-NAP1, CEP2, CNAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002042 11191 PTENP1 http://www.ncbi.nlm.nih.gov/gene/?term=11191 "PTEN-rs, PTEN2, PTENpg1, PTH2, psiPTEN " lncRNA Homo sapiens 25332394 Cytoplasm - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/PTENP1/ RLID00002043 11193 WBP4 http://www.ncbi.nlm.nih.gov/gene/?term=11193 FBP21 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002044 11194 ABCB8 http://www.ncbi.nlm.nih.gov/gene/?term=11194 "EST328128, M-ABC1, MABC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002045 11194 ABCB8 http://www.ncbi.nlm.nih.gov/gene/?term=11194 "EST328128, M-ABC1, MABC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002046 11196 SEC23IP http://www.ncbi.nlm.nih.gov/gene/?term=11196 "MSTP053, P125, P125A " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002047 11196 SEC23IP http://www.ncbi.nlm.nih.gov/gene/?term=11196 "MSTP053, P125, P125A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002048 111975 Igf2os http://www.ncbi.nlm.nih.gov/gene/?term=111975 "Igf2as, Peg8 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002049 11198 SUPT16H http://www.ncbi.nlm.nih.gov/gene/?term=11198 "CDC68, FACTP140, SPT16, SPT16/CDC68 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002050 11198 SUPT16H http://www.ncbi.nlm.nih.gov/gene/?term=11198 "CDC68, FACTP140, SPT16, SPT16/CDC68 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002051 1119 CHKA http://www.ncbi.nlm.nih.gov/gene/?term=1119 "CHK, CK, CKI, EK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002052 1119 CHKA http://www.ncbi.nlm.nih.gov/gene/?term=1119 "CHK, CK, CKI, EK " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002053 1119 CHKA http://www.ncbi.nlm.nih.gov/gene/?term=1119 "CHK, CK, CKI, EK " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002054 1119 CHKA http://www.ncbi.nlm.nih.gov/gene/?term=1119 "CHK, CK, CKI, EK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002055 11200 CHEK2 http://www.ncbi.nlm.nih.gov/gene/?term=11200 "CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002056 11201 POLI http://www.ncbi.nlm.nih.gov/gene/?term=11201 "RAD30B, RAD3OB " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002057 11201 POLI http://www.ncbi.nlm.nih.gov/gene/?term=11201 "RAD30B, RAD3OB " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002058 1120 CHKB http://www.ncbi.nlm.nih.gov/gene/?term=1120 "CHETK, CHKL, CK, CKB, CKEKB, EK, EKB, MDCMC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002059 11212 PROSC http://www.ncbi.nlm.nih.gov/gene/?term=11212 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002060 11212 PROSC http://www.ncbi.nlm.nih.gov/gene/?term=11212 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002061 11214 AKAP13 http://www.ncbi.nlm.nih.gov/gene/?term=11214 "AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002062 11214 AKAP13 http://www.ncbi.nlm.nih.gov/gene/?term=11214 "AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002063 11214 AKAP13 http://www.ncbi.nlm.nih.gov/gene/?term=11214 "AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002064 11214 AKAP13 http://www.ncbi.nlm.nih.gov/gene/?term=11214 "AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002065 11215 AKAP11 http://www.ncbi.nlm.nih.gov/gene/?term=11215 "AKAP-11, AKAP220, PPP1R44, PRKA11 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002066 11215 AKAP11 http://www.ncbi.nlm.nih.gov/gene/?term=11215 "AKAP-11, AKAP220, PPP1R44, PRKA11 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002067 11215 AKAP11 http://www.ncbi.nlm.nih.gov/gene/?term=11215 "AKAP-11, AKAP220, PPP1R44, PRKA11 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002068 11217 AKAP2 http://www.ncbi.nlm.nih.gov/gene/?term=11217 "AKAP-2, AKAPKL, PRKA2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002069 11218 DDX20 http://www.ncbi.nlm.nih.gov/gene/?term=11218 "DP103, GEMIN3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002070 11218 DDX20 http://www.ncbi.nlm.nih.gov/gene/?term=11218 "DP103, GEMIN3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002071 1121 CHM http://www.ncbi.nlm.nih.gov/gene/?term=1121 "DXS540, GGTA, HSD-32, REP-1, TCD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002072 11221 DUSP10 http://www.ncbi.nlm.nih.gov/gene/?term=11221 "MKP-5, MKP5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002073 11222 MRPL3 http://www.ncbi.nlm.nih.gov/gene/?term=11222 "COXPD9, MRL3, RPML3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002074 11224 RPL35 http://www.ncbi.nlm.nih.gov/gene/?term=11224 L35 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002075 11224 RPL35 http://www.ncbi.nlm.nih.gov/gene/?term=11224 L35 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002076 11224 RPL35 http://www.ncbi.nlm.nih.gov/gene/?term=11224 L35 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002077 11226 GALNT6 http://www.ncbi.nlm.nih.gov/gene/?term=11226 "GALNAC-T6, GalNAcT6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002078 11227 GALNT5 http://www.ncbi.nlm.nih.gov/gene/?term=11227 "GALNAC-T5, GALNACT5 " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00002079 11227 GALNT5 http://www.ncbi.nlm.nih.gov/gene/?term=11227 "GALNAC-T5, GALNACT5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002080 11227 GALNT5 http://www.ncbi.nlm.nih.gov/gene/?term=11227 "GALNAC-T5, GALNACT5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002081 1122 CHML http://www.ncbi.nlm.nih.gov/gene/?term=1122 REP2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002082 1122 CHML http://www.ncbi.nlm.nih.gov/gene/?term=1122 REP2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002083 11231 SEC63 http://www.ncbi.nlm.nih.gov/gene/?term=11231 "DNAJC23, ERdj2, PRO2507L, SEC63 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002084 11231 SEC63 http://www.ncbi.nlm.nih.gov/gene/?term=11231 "DNAJC23, ERdj2, PRO2507, SEC63L " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002085 11234 HPS5 http://www.ncbi.nlm.nih.gov/gene/?term=11234 "AIBP63, BLOC2S2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002086 11234 HPS5 http://www.ncbi.nlm.nih.gov/gene/?term=11234 "AIBP63, BLOC2S2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002087 11235 PDCD10 http://www.ncbi.nlm.nih.gov/gene/?term=11235 "CCM3, TFAR15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002088 11235 PDCD10 http://www.ncbi.nlm.nih.gov/gene/?term=11235 "CCM3, TFAR15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002089 11236 RNF139 http://www.ncbi.nlm.nih.gov/gene/?term=11236 "HRCA1, RCA1, TRC8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002090 11236 RNF139 http://www.ncbi.nlm.nih.gov/gene/?term=11236 "HRCA1, RCA1, TRC8 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002091 11237 RNF24 http://www.ncbi.nlm.nih.gov/gene/?term=11237 G1L mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002092 11238 CA5B http://www.ncbi.nlm.nih.gov/gene/?term=11238 CA-VB mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002093 11238 CA5B http://www.ncbi.nlm.nih.gov/gene/?term=11238 CA-VB mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002094 112399 EGLN3 http://www.ncbi.nlm.nih.gov/gene/?term=112399 "HIFP4H3, HIFPH3, PHD3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002095 112399 EGLN3 http://www.ncbi.nlm.nih.gov/gene/?term=112399 "HIFP4H3, HIFPH3, PHD3 " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00002096 1123 CHN1 http://www.ncbi.nlm.nih.gov/gene/?term=1123 "ARHGAP2, CHN, DURS2, NC, RHOGAP2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002097 112405 Egln1 http://www.ncbi.nlm.nih.gov/gene/?term=112405 "AI503754, C1orf12, HIF-PH2, HPH-2, Hif-p4h-2, ORF13, Phd2, SM-20 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002098 112406 Egln2 http://www.ncbi.nlm.nih.gov/gene/?term=112406 "0610011A13Rik, C85656, Hif-p4h-1, Ier4, Phd1, SM-20 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002099 11243 PMF1 http://www.ncbi.nlm.nih.gov/gene/?term=11243 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002100 11243 PMF1 http://www.ncbi.nlm.nih.gov/gene/?term=11243 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002101 11244 ZHX1 http://www.ncbi.nlm.nih.gov/gene/?term=11244 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002102 11245 GPR176 http://www.ncbi.nlm.nih.gov/gene/?term=11245 HB-954 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002103 112483 SAT2 http://www.ncbi.nlm.nih.gov/gene/?term=112483 SSAT2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002104 112487 DTD2 http://www.ncbi.nlm.nih.gov/gene/?term=112487 C14orf126 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002105 112487 DTD2 http://www.ncbi.nlm.nih.gov/gene/?term=112487 C14orf126 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002106 112487 DTD2 http://www.ncbi.nlm.nih.gov/gene/?term=112487 C14orf126 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002107 112487 DTD2 http://www.ncbi.nlm.nih.gov/gene/?term=112487 C14orf126 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002108 11248 NXPH3 http://www.ncbi.nlm.nih.gov/gene/?term=11248 NPH3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002109 112495 GTF3C6 http://www.ncbi.nlm.nih.gov/gene/?term=112495 "C6orf51, TFIIIC35, bA397G5.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002110 112495 GTF3C6 http://www.ncbi.nlm.nih.gov/gene/?term=112495 "C6orf51, TFIIIC35, bA397G5.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002111 11252 PACSIN2 http://www.ncbi.nlm.nih.gov/gene/?term=11252 SDPII mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002112 11252 PACSIN2 http://www.ncbi.nlm.nih.gov/gene/?term=11252 SDPII mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002113 11252 PACSIN2 http://www.ncbi.nlm.nih.gov/gene/?term=11252 SDPII mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002114 11253 MAN1B1 http://www.ncbi.nlm.nih.gov/gene/?term=11253 "ERMAN1, ERManI, MANA-ER, MRT15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002115 11253 MAN1B1 http://www.ncbi.nlm.nih.gov/gene/?term=11253 "ERMAN1, ERManI, MANA-ER, MRT15 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002116 11257 TP53TG1 http://www.ncbi.nlm.nih.gov/gene/?term=11257 "LINC00096, NCRNA00096, P53TG1, P53TG1-D, TP53AP1 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002117 11258 DCTN3 http://www.ncbi.nlm.nih.gov/gene/?term=11258 "DCTN-22, DCTN22 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002118 112597 LINC00152 http://www.ncbi.nlm.nih.gov/gene/?term=112597 "C2orf59, NCRNA00152 " lncRNA Homo sapiens 25391424 Exosome Plasma qRT-PCR "All these results suggested that LINC00152 can be detected in plasma, and one of the possible mechanisms of its stable existence in blood was protected by exosomes. " RLID00002119 112597 LINC00152 http://www.ncbi.nlm.nih.gov/gene/?term=112597 "C2orf59, NCRNA00152 " lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002120 112609 MRAP2 http://www.ncbi.nlm.nih.gov/gene/?term=112609 "BMIQ18, C6orf117, bA51G5.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002121 11260 XPOT http://www.ncbi.nlm.nih.gov/gene/?term=11260 XPO3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002122 11260 XPOT http://www.ncbi.nlm.nih.gov/gene/?term=11260 XPO3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002123 112611 RWDD2A http://www.ncbi.nlm.nih.gov/gene/?term=112611 "RWDD2, dJ747H23.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002124 112616 CMTM7 http://www.ncbi.nlm.nih.gov/gene/?term=112616 CKLFSF7 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002125 112616 CMTM7 http://www.ncbi.nlm.nih.gov/gene/?term=112616 CKLFSF7 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002126 11261 CHP1 http://www.ncbi.nlm.nih.gov/gene/?term=11261 "CHP, SLC9A1BP, Sid470p, p22, p24 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002127 11261 CHP1 http://www.ncbi.nlm.nih.gov/gene/?term=11261 "CHP, SLC9A1BP, Sid470p, p22, p24 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002128 11261 CHP1 http://www.ncbi.nlm.nih.gov/gene/?term=11261 "CHP, SLC9A1BP, Sid470p, p22, p24 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002129 11264 PXMP4 http://www.ncbi.nlm.nih.gov/gene/?term=11264 PMP24 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002130 11264 PXMP4 http://www.ncbi.nlm.nih.gov/gene/?term=11264 PMP24 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002131 11264 PXMP4 http://www.ncbi.nlm.nih.gov/gene/?term=11264 PMP24 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002132 11264 PXMP4 http://www.ncbi.nlm.nih.gov/gene/?term=11264 PMP24 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002133 11266 DUSP12 http://www.ncbi.nlm.nih.gov/gene/?term=11266 "DUSP1, YVH1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002134 11266 DUSP12 http://www.ncbi.nlm.nih.gov/gene/?term=11266 "DUSP1, YVH1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002135 11267 SNF8 http://www.ncbi.nlm.nih.gov/gene/?term=11267 "Dot3, EAP30, VPS22 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002136 11270 NRM http://www.ncbi.nlm.nih.gov/gene/?term=11270 NRM29 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002137 112724 RDH13 http://www.ncbi.nlm.nih.gov/gene/?term=112724 SDR7C3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002138 112724 RDH13 http://www.ncbi.nlm.nih.gov/gene/?term=112724 SDR7C3 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002139 112724 RDH13 http://www.ncbi.nlm.nih.gov/gene/?term=112724 SDR7C3 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002140 11272 PRR4 http://www.ncbi.nlm.nih.gov/gene/?term=11272 "LPRP, PROL4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002141 11273 ATXN2L http://www.ncbi.nlm.nih.gov/gene/?term=11273 "A2D, A2LG, A2LP, A2RP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002142 11274 USP18 http://www.ncbi.nlm.nih.gov/gene/?term=11274 "ISG43, UBP43 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002143 112752 IFT43 http://www.ncbi.nlm.nih.gov/gene/?term=112752 "C14orf179, CED3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002144 112755 STX1B http://www.ncbi.nlm.nih.gov/gene/?term=112755 "GEFSP9, STX1B1, STX1B2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002145 11276 SYNRG http://www.ncbi.nlm.nih.gov/gene/?term=11276 "AP1GBP1, SYNG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002146 11277 TREX1 http://www.ncbi.nlm.nih.gov/gene/?term=11277 "AGS1, CRV, DRN3, HERNS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002147 11279 KLF8 http://www.ncbi.nlm.nih.gov/gene/?term=11279 "BKLF3, ZNF741 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002148 11282 MGAT4B http://www.ncbi.nlm.nih.gov/gene/?term=11282 "GNT-IV, GNT-IVB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002149 112840 WDR89 http://www.ncbi.nlm.nih.gov/gene/?term=112840 "C14orf150, MSTP050 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002150 112840 WDR89 http://www.ncbi.nlm.nih.gov/gene/?term=112840 "C14orf150, MSTP050 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002151 11284 PNKP http://www.ncbi.nlm.nih.gov/gene/?term=11284 "AOA4, EIEE10, MCSZ, PNK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002152 112858 TP53RK http://www.ncbi.nlm.nih.gov/gene/?term=112858 "BUD32, C20orf64, Nori-2, Nori-2p, PRPK, dJ101A2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002153 112858 TP53RK http://www.ncbi.nlm.nih.gov/gene/?term=112858 "BUD32, C20orf64, Nori-2, Nori-2p, PRPK, dJ101A2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002154 11285 B4GALT7 http://www.ncbi.nlm.nih.gov/gene/?term=11285 "EDSP1, XGALT1, XGPT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002155 112936 VPS26B http://www.ncbi.nlm.nih.gov/gene/?term=112936 Pep8b mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002156 112936 VPS26B http://www.ncbi.nlm.nih.gov/gene/?term=112936 Pep8b mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002157 112936 VPS26B http://www.ncbi.nlm.nih.gov/gene/?term=112936 Pep8b mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002158 112937 GLB1L3 http://www.ncbi.nlm.nih.gov/gene/?term=112937 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002159 112937 GLB1L3 http://www.ncbi.nlm.nih.gov/gene/?term=112937 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002160 112939 NACC1 http://www.ncbi.nlm.nih.gov/gene/?term=112939 "BEND8, BTBD14B, BTBD30, NAC-1, NAC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002161 112942 CFAP36 http://www.ncbi.nlm.nih.gov/gene/?term=112942 CCDC104 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002162 112942 CFAP36 http://www.ncbi.nlm.nih.gov/gene/?term=112942 CCDC104 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002163 112950 MED8 http://www.ncbi.nlm.nih.gov/gene/?term=112950 ARC32 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002164 112970 KTI12 http://www.ncbi.nlm.nih.gov/gene/?term=112970 "SBBI81, TOT4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002165 112 ADCY6 http://www.ncbi.nlm.nih.gov/gene/?term=112 "AC6, LCCS8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002166 112 ADCY6 http://www.ncbi.nlm.nih.gov/gene/?term=112 "AC6, LCCS8 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002167 112 ADCY6 http://www.ncbi.nlm.nih.gov/gene/?term=112 "AC6, LCCS8 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002168 112 ADCY6 http://www.ncbi.nlm.nih.gov/gene/?term=112 "AC6, LCCS8 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002169 113000 RPUSD1 http://www.ncbi.nlm.nih.gov/gene/?term=113000 "C16orf40, RLUCL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002170 113000 RPUSD1 http://www.ncbi.nlm.nih.gov/gene/?term=113000 "C16orf40, RLUCL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002171 113026 PLCD3 http://www.ncbi.nlm.nih.gov/gene/?term=113026 PLC-delta-3 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002172 113026 PLCD3 http://www.ncbi.nlm.nih.gov/gene/?term=113026 PLC-delta-3 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002173 113026 PLCD3 http://www.ncbi.nlm.nih.gov/gene/?term=113026 PLC-delta-3 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002174 11304 Abca4 http://www.ncbi.nlm.nih.gov/gene/?term=11304 "AW050280, Abc10, Abcr, D430003I15Rik, RmP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002175 1130 LYST http://www.ncbi.nlm.nih.gov/gene/?term=1130 "CHS, CHS1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002176 113130 CDCA5 http://www.ncbi.nlm.nih.gov/gene/?term=113130 SORORIN mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002177 113130 CDCA5 http://www.ncbi.nlm.nih.gov/gene/?term=113130 SORORIN mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002178 113130 CDCA5 http://www.ncbi.nlm.nih.gov/gene/?term=113130 SORORIN mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002179 11313 LYPLA2 http://www.ncbi.nlm.nih.gov/gene/?term=11313 "APT-2, APT2, DJ886K2.4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002180 11314 CD300A http://www.ncbi.nlm.nih.gov/gene/?term=11314 "CLM-8, CMRF-35-H9, CMRF-35H, CMRF35-H, CMRF35-H9, CMRF35H, CMRF35H9, IGSF12, IRC1, IRC1/IRC2, IRC2, IRp60 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002181 11315 PARK7 http://www.ncbi.nlm.nih.gov/gene/?term=11315 "DJ-1, DJ1, HEL-S-67p " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002182 11316 COPE http://www.ncbi.nlm.nih.gov/gene/?term=11316 epsilon-COP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002183 11316 COPE http://www.ncbi.nlm.nih.gov/gene/?term=11316 epsilon-COP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002184 113174 SAAL1 http://www.ncbi.nlm.nih.gov/gene/?term=113174 SPACIA1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002185 113174 SAAL1 http://www.ncbi.nlm.nih.gov/gene/?term=113174 SPACIA1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002186 113177 IZUMO4 http://www.ncbi.nlm.nih.gov/gene/?term=113177 "C19orf36, IMAGE:4215339 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002187 113178 SCAMP4 http://www.ncbi.nlm.nih.gov/gene/?term=113178 SCAMP-4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002188 113178 SCAMP4 http://www.ncbi.nlm.nih.gov/gene/?term=113178 SCAMP-4 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002189 113178 SCAMP4 http://www.ncbi.nlm.nih.gov/gene/?term=113178 SCAMP-4 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002190 113178 SCAMP4 http://www.ncbi.nlm.nih.gov/gene/?term=113178 SCAMP-4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002191 113201 CASC4 http://www.ncbi.nlm.nih.gov/gene/?term=113201 H63 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002192 113201 CASC4 http://www.ncbi.nlm.nih.gov/gene/?term=113201 H63 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002193 11320 MGAT4A http://www.ncbi.nlm.nih.gov/gene/?term=11320 "GNT-IV, GNT-IVA, GnT-4a " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002194 11320 MGAT4A http://www.ncbi.nlm.nih.gov/gene/?term=11320 "GNT-IV, GNT-IVA, GnT-4a " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002195 11320 MGAT4A http://www.ncbi.nlm.nih.gov/gene/?term=11320 "GNT-IV, GNT-IVA, GnT-4a " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002196 11320 MGAT4A http://www.ncbi.nlm.nih.gov/gene/?term=11320 "GNT-IV, GNT-IVA, GnT-4a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002197 11321 GPN1 http://www.ncbi.nlm.nih.gov/gene/?term=11321 "ATPBD1A, MBDIN, NTPBP, RPAP4, XAB1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002198 11322 TMC6 http://www.ncbi.nlm.nih.gov/gene/?term=11322 "EV1, EVER1, EVIN1, LAK-4P " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002199 113235 SLC46A1 http://www.ncbi.nlm.nih.gov/gene/?term=113235 "G21, HCP1, PCFT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002200 113235 SLC46A1 http://www.ncbi.nlm.nih.gov/gene/?term=113235 "G21, HCP1, PCFT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002201 113246 C12orf57 http://www.ncbi.nlm.nih.gov/gene/?term=113246 "C10, GRCC10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002202 113251 LARP4 http://www.ncbi.nlm.nih.gov/gene/?term=113251 PP13296 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002203 113251 LARP4 http://www.ncbi.nlm.nih.gov/gene/?term=113251 PP13296 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002204 113263 GLCCI1 http://www.ncbi.nlm.nih.gov/gene/?term=113263 "FAM117C, GCTR, GIG18, TSSN1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002205 113263 GLCCI1 http://www.ncbi.nlm.nih.gov/gene/?term=113263 "FAM117C, GCTR, GIG18, TSSN1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002206 11326 VSIG4 http://www.ncbi.nlm.nih.gov/gene/?term=11326 "CRIg, Z39IG " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002207 11328 FKBP9 http://www.ncbi.nlm.nih.gov/gene/?term=11328 "FKBP60, FKBP63, PPIase " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002208 11328 FKBP9 http://www.ncbi.nlm.nih.gov/gene/?term=11328 "FKBP60, FKBP63, PPIase " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002209 11328 FKBP9 http://www.ncbi.nlm.nih.gov/gene/?term=11328 "FKBP60, FKBP63, PPIase " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002210 11331 PHB2 http://www.ncbi.nlm.nih.gov/gene/?term=11331 "BAP, BCAP37, Bap37, PNAS-141, REA, hBAP, p22 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002211 11332 ACOT7 http://www.ncbi.nlm.nih.gov/gene/?term=11332 "ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002212 11332 ACOT7 http://www.ncbi.nlm.nih.gov/gene/?term=11332 "ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002213 11332 ACOT7 http://www.ncbi.nlm.nih.gov/gene/?term=11332 "ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002214 11333 PDAP1 http://www.ncbi.nlm.nih.gov/gene/?term=11333 "HASPP28, PAP, PAP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002215 11333 PDAP1 http://www.ncbi.nlm.nih.gov/gene/?term=11333 "HASPP28, PAP, PAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002216 11334 TUSC2 http://www.ncbi.nlm.nih.gov/gene/?term=11334 "C3orf11, FUS1, PAP, PDAP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002217 11334 TUSC2 http://www.ncbi.nlm.nih.gov/gene/?term=11334 "C3orf11, FUS1, PAP, PDAP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002218 11335 CBX3 http://www.ncbi.nlm.nih.gov/gene/?term=11335 "HECH, HP1-GAMMA, HP1Hs-gamma " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002219 11335 CBX3 http://www.ncbi.nlm.nih.gov/gene/?term=11335 "HECH, HP1-GAMMA, HP1Hs-gamma " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002220 11336 EXOC3 http://www.ncbi.nlm.nih.gov/gene/?term=11336 "SEC6, SEC6L1, Sec6p " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002221 11337 GABARAP http://www.ncbi.nlm.nih.gov/gene/?term=11337 "ATG8A-a, MM46, GABARAP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002222 11337 GABARAP http://www.ncbi.nlm.nih.gov/gene/?term=11337 "ATG8A-a, MM46, GABARAP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002223 11337 GABARAP http://www.ncbi.nlm.nih.gov/gene/?term=11337 "ATG8A, GABARAP-a, MM46 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002224 11338 U2AF2 http://www.ncbi.nlm.nih.gov/gene/?term=11338 U2AF65 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002225 11338 U2AF2 http://www.ncbi.nlm.nih.gov/gene/?term=11338 U2AF65 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002226 11339 OIP5 http://www.ncbi.nlm.nih.gov/gene/?term=11339 "5730547N13Rik, CT86, LINT-25, MIS18B, MIS18beta, hMIS18beta " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002227 113402 SFT2D1 http://www.ncbi.nlm.nih.gov/gene/?term=113402 "C6orf83, pRGR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002228 113402 SFT2D1 http://www.ncbi.nlm.nih.gov/gene/?term=113402 "C6orf83, pRGR1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002229 11340 EXOSC8 http://www.ncbi.nlm.nih.gov/gene/?term=11340 "CIP3, EAP2, OIP2, PCH1C, RRP43, Rrp43p, bA421P11.3, p9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002230 11340 EXOSC8 http://www.ncbi.nlm.nih.gov/gene/?term=11340 "CIP3, EAP2, OIP2, PCH1C, RRP43, Rrp43p, bA421P11.3, p9 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002231 11340 EXOSC8 http://www.ncbi.nlm.nih.gov/gene/?term=11340 "CIP3, EAP2, OIP2, PCH1C, RRP43, Rrp43p, bA421P11.3, p9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002232 113419 TEX261 http://www.ncbi.nlm.nih.gov/gene/?term=113419 TEG-261 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002233 11342 RNF13 http://www.ncbi.nlm.nih.gov/gene/?term=11342 RZF mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002234 113444 SMIM12 http://www.ncbi.nlm.nih.gov/gene/?term=113444 C1orf212 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002235 113444 SMIM12 http://www.ncbi.nlm.nih.gov/gene/?term=113444 C1orf212 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002236 113444 SMIM12 http://www.ncbi.nlm.nih.gov/gene/?term=113444 C1orf212 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002237 113444 SMIM12 http://www.ncbi.nlm.nih.gov/gene/?term=113444 C1orf212 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002238 11344 TWF2 http://www.ncbi.nlm.nih.gov/gene/?term=11344 "A6RP, A6r, MSTP011, PTK9L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002239 113452 TMEM54 http://www.ncbi.nlm.nih.gov/gene/?term=113452 "BCLP, CAC-1, CAC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002240 113452 TMEM54 http://www.ncbi.nlm.nih.gov/gene/?term=113452 "BCLP, CAC-1, CAC1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002241 113457 TUBA3D http://www.ncbi.nlm.nih.gov/gene/?term=113457 H2-ALPHA mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002242 11345 GABARAPL2 http://www.ncbi.nlm.nih.gov/gene/?term=11345 "ATG8, ATG8C, GATE-16, GATE16, GEF-2, GEF2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002243 11345 GABARAPL2 http://www.ncbi.nlm.nih.gov/gene/?term=11345 "ATG8, ATG8C, GATE-16, GATE16, GEF-2, GEF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002244 11346 SYNPO http://www.ncbi.nlm.nih.gov/gene/?term=11346 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002245 11350 Abl1 http://www.ncbi.nlm.nih.gov/gene/?term=11350 "AI325092, Abl, E430008G22Rik, c-Abl " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002246 11354 Scgb1b27 http://www.ncbi.nlm.nih.gov/gene/?term=11354 "Abp, Abpa, Abpa27, Sal-1, Tcp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002247 113612 CYP2U1 http://www.ncbi.nlm.nih.gov/gene/?term=113612 "P450TEC, SPG49, SPG56 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002248 113612 CYP2U1 http://www.ncbi.nlm.nih.gov/gene/?term=113612 "P450TEC, SPG49, SPG56 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002249 113622 ADPRHL1 http://www.ncbi.nlm.nih.gov/gene/?term=113622 ARH2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002250 113655 MFSD3 http://www.ncbi.nlm.nih.gov/gene/?term=113655 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002251 113675 SDSL http://www.ncbi.nlm.nih.gov/gene/?term=113675 "SDH 2, SDS-RS1, TDH, cSDH " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002252 113675 SDSL http://www.ncbi.nlm.nih.gov/gene/?term=113675 "SDH 2, SDS-RS1, TDH, cSDH " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002253 113791 PIK3IP1 http://www.ncbi.nlm.nih.gov/gene/?term=113791 "HGFL, hHGFL(S) " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002254 113828 FAM83F http://www.ncbi.nlm.nih.gov/gene/?term=113828 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002255 113829 SLC35A4 http://www.ncbi.nlm.nih.gov/gene/?term=113829 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002256 113878 DTX2 http://www.ncbi.nlm.nih.gov/gene/?term=113878 RNF58 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002257 113892 Nat8f3 http://www.ncbi.nlm.nih.gov/gene/?term=113892 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002258 1139 CHRNA7 http://www.ncbi.nlm.nih.gov/gene/?term=1139 "CHRNA7-2, NACHRA7 " mRNA Homo sapiens 26206074 Nucleus Neocortex In situ hybridization "CHRNA7 and CHRFAM7A mRNAs were expressed in the same neuronal nuclei of the human neocortex. We demonstrated that CHRNA7 and CHRFAM7A mRNAs are colocalized in a subset of putative neuronal nuclei (large DAPI-stained nuclei), both in the dorsolateral prefrontal cortex and anterior cingulate cortex (Figure 3). " RLID00002259 113 ADCY7 http://www.ncbi.nlm.nih.gov/gene/?term=113 AC7 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002260 114034 TOE1 http://www.ncbi.nlm.nih.gov/gene/?term=114034 hCaf1z mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002261 114043 TSPEAR-AS2 http://www.ncbi.nlm.nih.gov/gene/?term=114043 C21orf90 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002262 114049 WBSCR22 http://www.ncbi.nlm.nih.gov/gene/?term=114049 "HASJ4442, HUSSY-3, MERM1, PP3381, WBMT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002263 114049 WBSCR22 http://www.ncbi.nlm.nih.gov/gene/?term=114049 "HASJ4442, HUSSY-3, MERM1, PP3381, WBMT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002264 11409 Acads http://www.ncbi.nlm.nih.gov/gene/?term=11409 "AI196007, Bcd-1, Bcd1, Hdlq8, SCAD " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002265 11416 Slc33a1 http://www.ncbi.nlm.nih.gov/gene/?term=11416 "AI315656, AI788741, Acatn, D630022N01Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002266 114255 Dok4 http://www.ncbi.nlm.nih.gov/gene/?term=114255 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002267 11426 Macf1 http://www.ncbi.nlm.nih.gov/gene/?term=11426 "ABP620, Acf7, Aclp7, MACF, R74989, mKIAA0465 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002268 114294 LACTB http://www.ncbi.nlm.nih.gov/gene/?term=114294 "G24, MRPL56 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002269 11431 Acp1 http://www.ncbi.nlm.nih.gov/gene/?term=11431 "4632432E04Rik, AI427468, Acp-1, LMW-PTP " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002270 114327 EFHC1 http://www.ncbi.nlm.nih.gov/gene/?term=114327 "EJM1, dJ304B14.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002271 11434 Acr http://www.ncbi.nlm.nih.gov/gene/?term=11434 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002272 11440 Chrna6 http://www.ncbi.nlm.nih.gov/gene/?term=11440 "Acra6, Nica6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002273 114548 NLRP3 http://www.ncbi.nlm.nih.gov/gene/?term=114548 "AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCAS1, FCU, MWS, NALP3, PYPAF1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002274 114548 NLRP3 http://www.ncbi.nlm.nih.gov/gene/?term=114548 "AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCAS1, FCU, MWS, NALP3, PYPAF1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002275 114564 Csprs http://www.ncbi.nlm.nih.gov/gene/?term=114564 "D1Lub1, HSR " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002276 114569 MAL2 http://www.ncbi.nlm.nih.gov/gene/?term=114569 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002277 114599 SNORD15B http://www.ncbi.nlm.nih.gov/gene/?term=114599 "RNU15B, U15B " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002278 114599 SNORD15B http://www.ncbi.nlm.nih.gov/gene/?term=114599 "RNU15B, U15B " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002279 114599 SNORD15B http://www.ncbi.nlm.nih.gov/gene/?term=114599 "RNU15B, U15B " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002280 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 22817891 Cytoplasm Bone marrow Macrophage Next-generation sequencing "Cluster 11, by contrast, contains abundant cytoplasmic transcripts, with fewer transcripts in the chromatin and nucleoplasm. This cluster includes genes that are likely to encode highly stable mRNAs, such as Actb (beta-actin) and Tuba (alpha-tubulin). " RLID00002281 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002282 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 14623865 Growth cone Motoneuron In situ hybridization "Overexpression of Smn or its binding partner, heterogeneous nuclear ribonucleoprotein (hnRNP) R, promotes neurite growth in differentiating PC12 cells. Reduced axon growth in Smn-deficient motoneurons correlates with reduced β-actin protein and mRNA staining in distal axons and growth cones.Overexpression of Smn or its binding partner, heterogeneous nuclear ribonucleoprotein (hnRNP) R, promotes neurite growth in differentiating PC12 cells. Reduced axon growth in Smn-deficient motoneurons correlates with reduced β-actin protein and mRNA staining in distal axons and growth cones. " RLID00002283 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 15972000 Endoplasmic reticulum MIN6 cell Northern blot "As expected, the actin mRNA was mainly found in the cytosolic fraction (Figure 2a). However, glucose stimulated the recruitment of a small fraction of the actin mRNA to the ER (Figure 2a). " RLID00002284 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 15972000 Cytosol MIN6 cell Northern blot "As expected, the actin mRNA was mainly found in the cytosolic fraction (Figure 2a). However, glucose stimulated the recruitment of a small fraction of the actin mRNA to the ER (Figure 2a). " RLID00002285 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 16317045 Dendrite Hippocampus In situ hybridization "Nd1-L transcripts were increased in the dendrites upon mGluR activation and significantly reduced in TLS-null dendrites. Cell in situ hybridization revealed that both Nd1-L and beta-actin mRNAs were increased in dendrites in DHPG-treated neurons by about 4.1-fold and 7.8-fold, respectively compared with those in non-treated WT neurons (Fig. 3A, left, and B). " RLID00002286 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 18195013 Ribosome S/S MEF cell RT-PCR "In the non-stressed S/S cells, actin mRNA was bound to large polyribosomes (Fig. 8,fractions 12-14). " RLID00002287 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 18539120 Dendrite Neuron Fluorescence in situ hybridization "Fig. 1 Fluorescence in situ hybridization (FISH) of hippocampal neurons. (a-d) Neurons from wild-type (WT, right panels) or FMRP-knockout (KO, left panels) were cultured for 10 days and either not stimulated ('unstim', upper panels') or stimulated with 50uM DHPG for 15 minutes ('DHPG' lower panels). Corresponding histograms showing dendritic quantification of FISH experiments are shown to the right. Results for WT (black bars) and KO (white bars) are labeled on the x-axis. Close-up images of dendritic signals are shown to the right (in same order). (a) MAP1b mRNA (n=15-16; *p<0.001 for unstimulated vs. DHPG in WT, P>0.25 for KO). (b)CaMKIIa mRNA (n=15-17; *p<0.01 for WT, p>0.2 for KO). There was no significant difference in CaMKIIa abundance of unstimulated neurons between WT and KO (n=15, p>0.1). (c) Beta-actin mRNA (n=11-13; p>0.2). Scale bars=12um. (d-e) FISH for other mRNA targets of FMRP in both WT (right image panels) and KO (left image panels). Representative images shown for unstimulated (upper panels; 'unstim' and stimulated (lower panels; DHPG, 50uM), and close-up images of dendrites are displayed above the histograms (in same order). Histograms (right) showing dendritic fluorescence quantification are shown for WT (green) and KO (red) using probes to (d) SAPAP4 (n=16-17; p<0.01 for WT, p>25 for KO) and (e) GABA-A receptor delta (n=13-15; *, ***p<0.01 for unstimulated vs. DHPG in WT and for DHPG in WT and KO, **p<0.05 for unstimulated vs. DHPG in KO). (c) Dendritic CaMKIIa mRNA localization in response to DHPG (11DIV). (d) Dendritic SAPAP4 mRNA localization in response to DHPG (11DIV). " RLID00002288 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 22832165 Cell leading edge Fibroblast Fluorescence in situ hybridization "Figure 2A shows a representative image of primary CEF cells in which β-actin mRNA is localized to the leading edge (indicated with arrowheads), whereas GAPDH mRNA is more uniformly distributed. " RLID00002289 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 24381269 Axon Soma qRT-PCR "As a control, the purity of the axonal RNA samples was tested by qRT-PCR, confirming that axonal samples were enriched in beta-actin mRNA and essentially devoid of beta-actin mRNA, which is present exclusively in the soma. " RLID00002290 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 26140598 Cell leading edge MEF cell Florescence micrograph "Next,we focused on the interaction in the cytoplasm, more specifically, the leading edge (Figure 2F, circle) and perinuclear regions (Figure 2F, square). In immortalized MEFs (Figures 2H and 2I), we found that ZBP1 bound b-actin mRNAs almost equally in both compartments (p > 0.1) (Figure 2J). It has been shown that b-actin mRNA localizes to the leading edge of primary fibroblasts. " RLID00002291 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 26140598 Perinuclear MEF cell Florescence micrograph "Next,we focused on the interaction in the cytoplasm, more specifically, the leading edge (Figure 2F, circle) and perinuclear regions (Figure 2F, square). In immortalized MEFs (Figures 2H and 2I), we found that ZBP1 bound b-actin mRNAs almost equally in both compartments (p > 0.1) (Figure 2J). These results provide a quantitative corroboration that ZBP1 binds b-actin mRNAs in the nuclear periphery and that phosphorylation of Y396F on ZBP1 leads to the release of the mRNA at the leading edge. " RLID00002292 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 26464439 Axon Motoneuron In situ hybridization|qRT-PCR "As a positive control, Actb, which has previously been detected in motor axons (8), was also abundant in the somatodendritic and axonal compartments. " RLID00002293 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 26464439 Somatodendritic compartment Motoneuron In situ hybridization|qRT-PCR "As a positive control, Actb, which has previously been detected in motor axons (8), was also abundant in the somatodendritic and axonal compartments. " RLID00002294 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 18451862 Lamellipodium Migrating cell qRT-PCR "These RNAs do not include beta-actin mRNA and the mRNAs for subunits of the arp2/3 complex, which have been previously observed at lamellipodial regions, possibly because in some cell types beta-actin mRNA accumulates at the leading edge in only a small percentage of cells. " RLID00002295 11461 Actb http://www.ncbi.nlm.nih.gov/gene/?term=11461 "Actx, E430023M04Rik, beta-actin " mRNA Mus musculus 18451862 Cell leading edge Migrating cell qRT-PCR "These RNAs do not include beta-actin mRNA and the mRNAs for subunits of the arp2/3 complex, which have been previously observed at lamellipodial regions, possibly because in some cell types beta-actin mRNA accumulates at the leading edge in only a small percentage of cells. " RLID00002296 114641 Rpl31 http://www.ncbi.nlm.nih.gov/gene/?term=114641 Dts mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002297 114641 Rpl31 http://www.ncbi.nlm.nih.gov/gene/?term=114641 Dts mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002298 114670 4930573O21Rik http://www.ncbi.nlm.nih.gov/gene/?term=114670 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002299 114671 4930444G20Rik http://www.ncbi.nlm.nih.gov/gene/?term=114671 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002300 114675 4932431P20Rik http://www.ncbi.nlm.nih.gov/gene/?term=114675 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002301 114713 Rasa2 http://www.ncbi.nlm.nih.gov/gene/?term=114713 "5430433H21Rik, AA517451, AU023900, GAP1m " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002302 114715 Spred1 http://www.ncbi.nlm.nih.gov/gene/?term=114715 "5730461F13Rik, AL024345, AW047647 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002303 114716 Spred2 http://www.ncbi.nlm.nih.gov/gene/?term=114716 C79158 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002304 11472 Actn2 http://www.ncbi.nlm.nih.gov/gene/?term=11472 1110008F24Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002305 114741 Supt16 http://www.ncbi.nlm.nih.gov/gene/?term=114741 "Cdc68, Fact140, Spt16h, Supt16 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002306 114757 CYGB http://www.ncbi.nlm.nih.gov/gene/?term=114757 "HGB, STAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002307 11477 Acvr1 http://www.ncbi.nlm.nih.gov/gene/?term=11477 "ALK2, ActR-I, ActRIA, Acvr, Acvrlk2, Alk-2, Alk8, D330013D15Rik, SKR1, Tsk7L " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002308 11477 Acvr1 http://www.ncbi.nlm.nih.gov/gene/?term=11477 "ALK2, ActR-I, ActRIA, Acvr, Acvrlk2, Alk-2, Alk8, D330013D15Rik, SKR1, Tsk7L " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002309 114781 BTBD9 http://www.ncbi.nlm.nih.gov/gene/?term=114781 dJ322I12.1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002310 114789 SLC25A25 http://www.ncbi.nlm.nih.gov/gene/?term=114789 "MCSC, PCSCL, SCAMC-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002311 114789 SLC25A25 http://www.ncbi.nlm.nih.gov/gene/?term=114789 "MCSC, PCSCL, SCAMC-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002312 114793 FMNL2 http://www.ncbi.nlm.nih.gov/gene/?term=114793 FHOD2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002313 114793 FMNL2 http://www.ncbi.nlm.nih.gov/gene/?term=114793 FHOD2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002314 1147 CHUK http://www.ncbi.nlm.nih.gov/gene/?term=1147 "IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002315 114804 RNF157 http://www.ncbi.nlm.nih.gov/gene/?term=114804 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002316 114804 RNF157 http://www.ncbi.nlm.nih.gov/gene/?term=114804 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002317 114804 RNF157 http://www.ncbi.nlm.nih.gov/gene/?term=114804 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002318 11481 Acvr2b http://www.ncbi.nlm.nih.gov/gene/?term=11481 "4930516B21Rik, ActRIIB " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002319 114822 RHPN1 http://www.ncbi.nlm.nih.gov/gene/?term=114822 "ODF5, RHOPHILIN, RHPN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002320 114822 RHPN1 http://www.ncbi.nlm.nih.gov/gene/?term=114822 "ODF5, RHOPHILIN, RHPN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002321 114825 PWWP2A http://www.ncbi.nlm.nih.gov/gene/?term=114825 MST101 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002322 114825 PWWP2A http://www.ncbi.nlm.nih.gov/gene/?term=114825 MST101 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002323 11486 Ada http://www.ncbi.nlm.nih.gov/gene/?term=11486 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002324 114871 Psg28 http://www.ncbi.nlm.nih.gov/gene/?term=114871 cea16 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002325 114874 Ddhd1 http://www.ncbi.nlm.nih.gov/gene/?term=114874 "Mir5131, PA-PLA1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002326 114879 OSBPL5 http://www.ncbi.nlm.nih.gov/gene/?term=114879 "OBPH1, ORP5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002327 114879 OSBPL5 http://www.ncbi.nlm.nih.gov/gene/?term=114879 "OBPH1, ORP5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002328 11487 Adam10 http://www.ncbi.nlm.nih.gov/gene/?term=11487 "1700031C13Rik, MADM, kuz, kuzbanian " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002329 114880 OSBPL6 http://www.ncbi.nlm.nih.gov/gene/?term=114880 ORP6 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002330 114882 OSBPL8 http://www.ncbi.nlm.nih.gov/gene/?term=114882 "MST120, MSTP120, ORP8, OSBP10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002331 114882 OSBPL8 http://www.ncbi.nlm.nih.gov/gene/?term=114882 "MST120, MSTP120, ORP8, OSBP10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002332 114884 OSBPL10 http://www.ncbi.nlm.nih.gov/gene/?term=114884 "ORP10, OSBP9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002333 114884 OSBPL10 http://www.ncbi.nlm.nih.gov/gene/?term=114884 "ORP10, OSBP9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002334 114885 OSBPL11 http://www.ncbi.nlm.nih.gov/gene/?term=114885 "ORP-11, ORP11, OSBP12, TCCCIA00292 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002335 114893 Dcun1d1 http://www.ncbi.nlm.nih.gov/gene/?term=114893 "Rp42, SCCRO, Tes3, pTes3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002336 114899 C1QTNF3 http://www.ncbi.nlm.nih.gov/gene/?term=114899 "C1ATNF3, CORCS, CORS, CORS-26, CORS26, CTRP3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002337 114899 C1QTNF3 http://www.ncbi.nlm.nih.gov/gene/?term=114899 "C1ATNF3, CORCS, CORS, CORS-26, CORS26, CTRP3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002338 114904 C1QTNF6 http://www.ncbi.nlm.nih.gov/gene/?term=114904 "CTFP6, CTRP6, ZACRP6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002339 114915 EPB41L4A-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=114915 "C5orf26, NCRNA00219, TIGA1 " lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002340 114915 EPB41L4A-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=114915 "C5orf26, NCRNA00219, TIGA1 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002341 11491 Adam17 http://www.ncbi.nlm.nih.gov/gene/?term=11491 "CD156b, Tace " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002342 114926 SMIM19 http://www.ncbi.nlm.nih.gov/gene/?term=114926 C8orf40 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002343 114926 SMIM19 http://www.ncbi.nlm.nih.gov/gene/?term=114926 C8orf40 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002344 114932 MRFAP1L1 http://www.ncbi.nlm.nih.gov/gene/?term=114932 PP784 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002345 114971 PTPMT1 http://www.ncbi.nlm.nih.gov/gene/?term=114971 "DUSP23, MOSP, PLIP, PNAS-129 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002346 114971 PTPMT1 http://www.ncbi.nlm.nih.gov/gene/?term=114971 "DUSP23, MOSP, PLIP, PNAS-129 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002347 114984 FLYWCH2 http://www.ncbi.nlm.nih.gov/gene/?term=114984 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002348 114984 FLYWCH2 http://www.ncbi.nlm.nih.gov/gene/?term=114984 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002349 114987 WDR31 http://www.ncbi.nlm.nih.gov/gene/?term=114987 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002350 114991 ZNF618 http://www.ncbi.nlm.nih.gov/gene/?term=114991 "FP13169, NEDD10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002351 11500 Adam7 http://www.ncbi.nlm.nih.gov/gene/?term=11500 "ADAM 7, EAP1, EAPI " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002352 115024 NT5C3B http://www.ncbi.nlm.nih.gov/gene/?term=115024 "NT5C3L, cN-IIIB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002353 115024 NT5C3B http://www.ncbi.nlm.nih.gov/gene/?term=115024 NT5C3L mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002354 11502 Adam9 http://www.ncbi.nlm.nih.gov/gene/?term=11502 "AU020942, MDC9, Mltng, mKIAA0021 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002355 115098 CCDC124 http://www.ncbi.nlm.nih.gov/gene/?term=115098 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002356 115098 CCDC124 http://www.ncbi.nlm.nih.gov/gene/?term=115098 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002357 115106 HAUS1 http://www.ncbi.nlm.nih.gov/gene/?term=115106 "CCDC5, HEI-C, HEIC, HsT1461 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002358 115123 MARCH3 http://www.ncbi.nlm.nih.gov/gene/?term=115123 "MARCH-III, RNF173 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002359 11515 Adcy9 http://www.ncbi.nlm.nih.gov/gene/?term=11515 "AC9, ACtp10, AW125421, D16Wsu65e, mKIAA0520 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002360 11517 Adcyap1r1 http://www.ncbi.nlm.nih.gov/gene/?term=11517 "2900024I10Rik, AI846590, PAC1, PAC1R, PACAP1-R " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002361 115196 ZNF554 http://www.ncbi.nlm.nih.gov/gene/?term=115196 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002362 115196 ZNF554 http://www.ncbi.nlm.nih.gov/gene/?term=115196 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002363 115201 ATG4A http://www.ncbi.nlm.nih.gov/gene/?term=115201 "APG4A, AUTL2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002364 115201 ATG4A http://www.ncbi.nlm.nih.gov/gene/?term=115201 "APG4A, AUTL2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002365 115209 OMA1 http://www.ncbi.nlm.nih.gov/gene/?term=115209 "2010001O09Rik, DAB1, MPRP-1, YKR087C, ZMPOMA1, peptidase " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002366 115209 OMA1 http://www.ncbi.nlm.nih.gov/gene/?term=115209 "2010001O09Rik, DAB1, MPRP-1, YKR087C, ZMPOMA1, peptidase " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002367 11520 Plin2 http://www.ncbi.nlm.nih.gov/gene/?term=11520 "AA407157, ADPH, Adfp, Adrp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002368 115286 SLC25A26 http://www.ncbi.nlm.nih.gov/gene/?term=115286 "COXPD28, SAMC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002369 1152 CKB http://www.ncbi.nlm.nih.gov/gene/?term=1152 "B-CK, BCKB, HEL-211, HEL-S-29, CKB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002370 1152 CKB http://www.ncbi.nlm.nih.gov/gene/?term=1152 "B-CK, BCKB, HEL-211, HEL-S-29, CKB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002371 1152 CKB http://www.ncbi.nlm.nih.gov/gene/?term=1152 "B-CK, BCK, CKBB, HEL-211, HEL-S-29 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002372 115330 GPR146 http://www.ncbi.nlm.nih.gov/gene/?term=115330 PGR8 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002373 115350 FCRL1 http://www.ncbi.nlm.nih.gov/gene/?term=115350 "CD307a, FCRH1, IFGP1, IRTA5 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002374 115350 FCRL1 http://www.ncbi.nlm.nih.gov/gene/?term=115350 "CD307a, FCRH1, IFGP1, IRTA5 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002375 115353 LRRC42 http://www.ncbi.nlm.nih.gov/gene/?term=115353 dJ167A19.4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002376 115353 LRRC42 http://www.ncbi.nlm.nih.gov/gene/?term=115353 dJ167A19.4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002377 115361 GBP4 http://www.ncbi.nlm.nih.gov/gene/?term=115361 Mpa2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002378 115361 GBP4 http://www.ncbi.nlm.nih.gov/gene/?term=115361 Mpa2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002379 115399 LRRC56 http://www.ncbi.nlm.nih.gov/gene/?term=115399 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002380 115399 LRRC56 http://www.ncbi.nlm.nih.gov/gene/?term=115399 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002381 115399 LRRC56 http://www.ncbi.nlm.nih.gov/gene/?term=115399 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002382 11539 Adora1 http://www.ncbi.nlm.nih.gov/gene/?term=11539 "A1-AR, A1AR, A1R, AA1R, AI848715, BB176431, Ri " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002383 1153 CIRBP http://www.ncbi.nlm.nih.gov/gene/?term=1153 CIRP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002384 1153 CIRBP http://www.ncbi.nlm.nih.gov/gene/?term=1153 CIRP mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002385 1153 CIRBP http://www.ncbi.nlm.nih.gov/gene/?term=1153 CIRP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002386 11540 Adora2a http://www.ncbi.nlm.nih.gov/gene/?term=11540 "A2AAR, A2aR, AA2AR " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002387 115416 MALSU1 http://www.ncbi.nlm.nih.gov/gene/?term=115416 "C7orf30, mtRsfA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002388 115416 MALSU1 http://www.ncbi.nlm.nih.gov/gene/?term=115416 "C7orf30, mtRsfA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002389 115426 UHRF2 http://www.ncbi.nlm.nih.gov/gene/?term=115426 "NIRF, RNF107, TDRD23, URF2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002390 11545 Parp1 http://www.ncbi.nlm.nih.gov/gene/?term=11545 "5830444G22Rik, AI893648, ARTD1, Adprp, Adprt1, C80510, PARP, PPOL, parp-1, sPARP-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002391 11546 Parp2 http://www.ncbi.nlm.nih.gov/gene/?term=11546 "ARTD2, Adprt2, Adprtl2, Aspartl2, C78626, PARP-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002392 1154 CISH http://www.ncbi.nlm.nih.gov/gene/?term=1154 "BACTS2, CIS, CIS-1, G18, SOCS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002393 11554 Adrb1 http://www.ncbi.nlm.nih.gov/gene/?term=11554 "Adrb-1, beta-AR " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002394 115560 ZNF501 http://www.ncbi.nlm.nih.gov/gene/?term=115560 "ZNF, ZNF52 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002395 115560 ZNF501 http://www.ncbi.nlm.nih.gov/gene/?term=115560 "ZNF, ZNF52 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002396 115560 ZNF501 http://www.ncbi.nlm.nih.gov/gene/?term=115560 "ZNF, ZNF52 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002397 1155 TBCB http://www.ncbi.nlm.nih.gov/gene/?term=1155 "CG22, CKAP1, CKAPI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002398 1155 TBCB http://www.ncbi.nlm.nih.gov/gene/?term=1155 "CG22, CKAP1, CKAPI " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002399 1155 TBCB http://www.ncbi.nlm.nih.gov/gene/?term=1155 "CG22, CKAP1, CKAPI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002400 11566 Adss http://www.ncbi.nlm.nih.gov/gene/?term=11566 "AI314886, AS2, Adss " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002401 11568 Aebp1 http://www.ncbi.nlm.nih.gov/gene/?term=11568 ACLP mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002402 11569 Aebp2 http://www.ncbi.nlm.nih.gov/gene/?term=11569 "AU023766, B230313N05Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002403 11569 Aebp2 http://www.ncbi.nlm.nih.gov/gene/?term=11569 "AU023766, B230313N05Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002404 115704 EVI5L http://www.ncbi.nlm.nih.gov/gene/?term=115704 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002405 115708 TRMT61A http://www.ncbi.nlm.nih.gov/gene/?term=115708 "C14orf172, GCD14, Gcd14p, TRM61, hTRM61 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002406 115727 RASGRP4 http://www.ncbi.nlm.nih.gov/gene/?term=115727 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002407 115749 C12orf56 http://www.ncbi.nlm.nih.gov/gene/?term=115749 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002408 115761 ARL11 http://www.ncbi.nlm.nih.gov/gene/?term=115761 ARLTS1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002409 115761 ARL11 http://www.ncbi.nlm.nih.gov/gene/?term=115761 ARLTS1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002410 115817 DHRS1 http://www.ncbi.nlm.nih.gov/gene/?term=115817 SDR19C1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002411 115825 WDFY2 http://www.ncbi.nlm.nih.gov/gene/?term=115825 "PROF, WDF2, ZFYVE22 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002412 115827 RAB3C http://www.ncbi.nlm.nih.gov/gene/?term=115827 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002413 115939 TSR3 http://www.ncbi.nlm.nih.gov/gene/?term=115939 C16orf42 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002414 115948 CCDC151 http://www.ncbi.nlm.nih.gov/gene/?term=115948 CILD30 mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00002415 11595 Acan http://www.ncbi.nlm.nih.gov/gene/?term=11595 "Agc, Agc1, Cspg1, b2b183Clo, cmd " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002416 115992 RNF166 http://www.ncbi.nlm.nih.gov/gene/?term=115992 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002417 1159 CKMT1B http://www.ncbi.nlm.nih.gov/gene/?term=1159 "CKMT, CKMT1, UMTCK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002418 116028 RMI2 http://www.ncbi.nlm.nih.gov/gene/?term=116028 "BLAP18, C16orf75 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002419 11603 Agrn http://www.ncbi.nlm.nih.gov/gene/?term=11603 "Agrin, nmf380 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002420 116064 LRRC58 http://www.ncbi.nlm.nih.gov/gene/?term=116064 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002421 116064 LRRC58 http://www.ncbi.nlm.nih.gov/gene/?term=116064 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002422 116064 LRRC58 http://www.ncbi.nlm.nih.gov/gene/?term=116064 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002423 116064 LRRC58 http://www.ncbi.nlm.nih.gov/gene/?term=116064 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002424 1160 CKMT2 http://www.ncbi.nlm.nih.gov/gene/?term=1160 SMTCK mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002425 116113 FOXP4 http://www.ncbi.nlm.nih.gov/gene/?term=116113 hFKHLA mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002426 116113 FOXP4 http://www.ncbi.nlm.nih.gov/gene/?term=116113 hFKHLA mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002427 116115 ZNF526 http://www.ncbi.nlm.nih.gov/gene/?term=116115 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002428 116115 ZNF526 http://www.ncbi.nlm.nih.gov/gene/?term=116115 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002429 116115 ZNF526 http://www.ncbi.nlm.nih.gov/gene/?term=116115 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002430 116115 ZNF526 http://www.ncbi.nlm.nih.gov/gene/?term=116115 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002431 116138 KLHDC3 http://www.ncbi.nlm.nih.gov/gene/?term=116138 "PEAS, dJ20C7.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002432 116143 WDR92 http://www.ncbi.nlm.nih.gov/gene/?term=116143 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002433 116143 WDR92 http://www.ncbi.nlm.nih.gov/gene/?term=116143 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002434 116150 NUS1 http://www.ncbi.nlm.nih.gov/gene/?term=116150 "C6orf68, MGC:7199, NgBR, TANGO14 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002435 116151 FAM210B http://www.ncbi.nlm.nih.gov/gene/?term=116151 "5A3, C20orf108, dJ1167H4.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002436 116159 CYYR1 http://www.ncbi.nlm.nih.gov/gene/?term=116159 C21orf95 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002437 1161 ERCC8 http://www.ncbi.nlm.nih.gov/gene/?term=1161 "CKN1, CSA, UVSS2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002438 1161 ERCC8 http://www.ncbi.nlm.nih.gov/gene/?term=1161 "CKN1, CSA, UVSS2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002439 116225 ZMYND19 http://www.ncbi.nlm.nih.gov/gene/?term=116225 MIZIP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002440 116228 COX20 http://www.ncbi.nlm.nih.gov/gene/?term=116228 FAM36A mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002441 116228 COX20 http://www.ncbi.nlm.nih.gov/gene/?term=116228 FAM36A mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002442 11622 Ahr http://www.ncbi.nlm.nih.gov/gene/?term=11622 "Ah, Ahhe, In, bHLHe76, Ahr " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002443 116236 ABHD15 http://www.ncbi.nlm.nih.gov/gene/?term=116236 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002444 116236 ABHD15 http://www.ncbi.nlm.nih.gov/gene/?term=116236 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002445 116238 TLCD1 http://www.ncbi.nlm.nih.gov/gene/?term=116238 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002446 11632 Aip http://www.ncbi.nlm.nih.gov/gene/?term=11632 "AA408703, AW476050, Ara9, D19Bwg1412e, Fkbp16, Xap2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002447 116349 EXOC3-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=116349 C5orf55 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002448 116349 EXOC3-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=116349 C5orf55 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002449 11634 Aire http://www.ncbi.nlm.nih.gov/gene/?term=11634 mRNA Mus musculus 18322189 Dendrite Embryotem cell qRT-PCR "Although in agreement with previous studies, low levels of Aire mRNA was detected in all dendritic cell subtypes however lacZ staining, immunohistochemistry and flow cytometry failed to detect Aire protein. " RLID00002450 116362 RBP7 http://www.ncbi.nlm.nih.gov/gene/?term=116362 "CRBP4, CRBPIV " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002451 116369 SLC26A8 http://www.ncbi.nlm.nih.gov/gene/?term=116369 "SPGF3, TAT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002452 11636 Ak1 http://www.ncbi.nlm.nih.gov/gene/?term=11636 "Ak-1, B430205N08Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002453 1163 CKS1B http://www.ncbi.nlm.nih.gov/gene/?term=1163 "CKS1, PNAS-16, PNAS-18, ckshs1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002454 1163 CKS1B http://www.ncbi.nlm.nih.gov/gene/?term=1163 "CKS1, PNAS-16, PNAS-18, ckshs1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002455 116461 TSEN15 http://www.ncbi.nlm.nih.gov/gene/?term=116461 "C1orf19, sen15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002456 116461 TSEN15 http://www.ncbi.nlm.nih.gov/gene/?term=116461 "C1orf19, sen15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002457 116496 FAM129A http://www.ncbi.nlm.nih.gov/gene/?term=116496 "C1orf24, GIG39, NIBAN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002458 116496 FAM129A http://www.ncbi.nlm.nih.gov/gene/?term=116496 "C1orf24, GIG39, NIBAN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002459 116496 FAM129A http://www.ncbi.nlm.nih.gov/gene/?term=116496 "C1orf24, GIG39, NIBAN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002460 116496 FAM129A http://www.ncbi.nlm.nih.gov/gene/?term=116496 "C1orf24, GIG39, NIBAN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002461 1164 CKS2 http://www.ncbi.nlm.nih.gov/gene/?term=1164 CKSHS2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002462 1164 CKS2 http://www.ncbi.nlm.nih.gov/gene/?term=1164 CKSHS2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002463 1164 CKS2 http://www.ncbi.nlm.nih.gov/gene/?term=1164 CKSHS2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002464 116541 MRPL54 http://www.ncbi.nlm.nih.gov/gene/?term=116541 "L54mt, MRP-L54 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002465 11657 Alb http://www.ncbi.nlm.nih.gov/gene/?term=11657 "Alb-11, BCL002, Alb " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002466 116636 Eif4ebp1 http://www.ncbi.nlm.nih.gov/gene/?term=116636 PHAS-I mRNA Rattus norvegicus 23091324 Dendrite Hippocampus Fluorescence in situ hybridization "In situ hybridization (ISH) and Fluorescence ISH (FISH) revealed that 4EBP1 mRNA was present in dendrites. In the present report we provide evidence that eIF4E-binding protein 1 (4EBP1) and its mRNA are also localized to dendrites in unstimulated rat hippocampal neurons, and that KCl treatment upregulates the mRNA in dendrites. The FISH signals for 4EBP1 mRNA are distributed in clusters along dendrites (Fig. 2B, AS-4EBP1). " RLID00002467 11666 Abcd1 http://www.ncbi.nlm.nih.gov/gene/?term=11666 "ALDP, Ald, Aldgh " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002468 11670 Aldh3a1 http://www.ncbi.nlm.nih.gov/gene/?term=11670 "Ahd-4, Ahd4, Aldh, Aldh3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002469 11674 Aldoa http://www.ncbi.nlm.nih.gov/gene/?term=11674 "Aldo-1, Aldo1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002470 11674 Aldoa http://www.ncbi.nlm.nih.gov/gene/?term=11674 "Aldo-1, Aldo1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002471 11677 Akr1b3 http://www.ncbi.nlm.nih.gov/gene/?term=11677 "ALR2, AR, Ahr-1, Ahr1, Akr1b1, Aldor1, Aldr1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002472 116832 RPL39L http://www.ncbi.nlm.nih.gov/gene/?term=116832 RPL39L1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002473 116838 Rims2 http://www.ncbi.nlm.nih.gov/gene/?term=116838 "2810036I15Rik, AW048769, RIM2, Rab3ip2, Rim2(+40A), Rim2(+44A), Rim2(+4A), Serg2, Syt3-rs, mKIAA0751 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002474 116840 CNTROB http://www.ncbi.nlm.nih.gov/gene/?term=116840 "LIP8, PP1221 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002475 116840 CNTROB http://www.ncbi.nlm.nih.gov/gene/?term=116840 "LIP8, PP1221 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002476 116841 SNAP47 http://www.ncbi.nlm.nih.gov/gene/?term=116841 "C1orf142, ESFI5812, HEL-S-290, HEL170, SNAP-47, SVAP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002477 116843 SLC18B1 http://www.ncbi.nlm.nih.gov/gene/?term=116843 "C6orf192, dJ55C23.6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002478 116843 SLC18B1 http://www.ncbi.nlm.nih.gov/gene/?term=116843 "C6orf192, dJ55C23.6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002479 116850 A430106F20Rik http://www.ncbi.nlm.nih.gov/gene/?term=116850 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002480 116871 Mta3 http://www.ncbi.nlm.nih.gov/gene/?term=116871 "1110002J22Rik, mKIAA1266 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002481 116905 Dph1 http://www.ncbi.nlm.nih.gov/gene/?term=116905 "2310011M22Rik, 4930488F09Rik, AW551873, Dph2l1, Ovca1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002482 116914 Slc19a2 http://www.ncbi.nlm.nih.gov/gene/?term=116914 "AV276020, AW322295, DDA1, THTR1, TRMA " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002483 116937 SNORD83A http://www.ncbi.nlm.nih.gov/gene/?term=116937 "RNU83A, U83A " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00002484 116937 SNORD83A http://www.ncbi.nlm.nih.gov/gene/?term=116937 "RNU83A, U83A " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002485 116937 SNORD83A http://www.ncbi.nlm.nih.gov/gene/?term=116937 "RNU83A, U83A " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00002486 116937 SNORD83A http://www.ncbi.nlm.nih.gov/gene/?term=116937 "RNU83A, U83A " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002487 116938 SNORD83B http://www.ncbi.nlm.nih.gov/gene/?term=116938 "RNU83B, U83B " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00002488 116938 SNORD83B http://www.ncbi.nlm.nih.gov/gene/?term=116938 "RNU83B, U83B " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002489 116938 SNORD83B http://www.ncbi.nlm.nih.gov/gene/?term=116938 "RNU83B, U83B " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002490 116983 ACAP3 http://www.ncbi.nlm.nih.gov/gene/?term=116983 CENTB5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002491 116984 ARAP2 http://www.ncbi.nlm.nih.gov/gene/?term=116984 "CENTD1, PARX " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002492 116988 AGAP3 http://www.ncbi.nlm.nih.gov/gene/?term=116988 "AGAP-3, CENTG3, CRAG, MRIP-1, cnt-g3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002493 11702 Amd1 http://www.ncbi.nlm.nih.gov/gene/?term=11702 "AdoMetDC, Amd-1, SAMDC, SAMDC 1, adoMetDC1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002494 117030 Erp29 http://www.ncbi.nlm.nih.gov/gene/?term=117030 mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00002495 117030 Erp29 http://www.ncbi.nlm.nih.gov/gene/?term=117030 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00002496 117143 TADA1 http://www.ncbi.nlm.nih.gov/gene/?term=117143 "ADA1, HFI1, STAF42L, hADA1, TADA1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002497 117143 TADA1 http://www.ncbi.nlm.nih.gov/gene/?term=117143 "ADA1, HFI1, STAF42, TADA1L, hADA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002498 117145 THEM4 http://www.ncbi.nlm.nih.gov/gene/?term=117145 CTMP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002499 117177 RAB3IP http://www.ncbi.nlm.nih.gov/gene/?term=117177 "RABIN3, RABIN8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002500 117178 SSX2IP http://www.ncbi.nlm.nih.gov/gene/?term=117178 ADIP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002501 117178 SSX2IP http://www.ncbi.nlm.nih.gov/gene/?term=117178 ADIP mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002502 117178 SSX2IP http://www.ncbi.nlm.nih.gov/gene/?term=117178 ADIP mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002503 117178 SSX2IP http://www.ncbi.nlm.nih.gov/gene/?term=117178 ADIP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002504 117198 Ivns1abp http://www.ncbi.nlm.nih.gov/gene/?term=117198 "1190004M08Rik, 1700126I16Rik, AA960440, HSPC068, ND1, NS-1, NS1-BP, Nd1-L, Nd1-S, mKIAA0850 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002505 117198 Ivns1abp http://www.ncbi.nlm.nih.gov/gene/?term=117198 "1190004M08Rik, 1700126I16Rik, AA960440, HSPC068, ND1, NS-1, NS1-BP, Nd1-L, Nd1-S, mKIAA0850 " mRNA Mus musculus 16317045 Dendrite Hippocampus In situ hybridization "Nd1-L transcripts were increased in the dendrites upon mGluR activation and significantly reduced in TLS-null dendrites. Cell in situ hybridization revealed that both Nd1-L and beta-actin mRNAs were increased in dendrites in DHPG-treated neurons by about 4.1-fold and 7.8-fold, respectively compared with those in non-treated WT neurons (Fig. 3A, left, and B). " RLID00002506 11720 Mat1a http://www.ncbi.nlm.nih.gov/gene/?term=11720 "AI046368, AdoMet, Ams, MAT, MATA1, SAMS, SAMS1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002507 117246 FTSJ3 http://www.ncbi.nlm.nih.gov/gene/?term=117246 "EPCS3, SPB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002508 117254 Prdx1 http://www.ncbi.nlm.nih.gov/gene/?term=117254 Hbp23 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00002509 117273 Rhoa http://www.ncbi.nlm.nih.gov/gene/?term=117273 "Arha, Arha2 " mRNA Rattus norvegicus 16723529 Growth cone Embryo In situ hybridization "RhoA mRNA is localized to axons and growth cones, and intra-axonal translation of RhoA is required for growth cone collapse elicited by Semaphorin 3A (Sema3A), an axonal guidance cue. Selective knock-down of axonal RhoA mRNA abolishes Sema3A-dependent growth cone collapse " RLID00002510 117273 Rhoa http://www.ncbi.nlm.nih.gov/gene/?term=117273 "Arha, Arha2 " mRNA Rattus norvegicus 16723529 Axon Embryo In situ hybridization "RhoA mRNA is localized to axons and growth cones, and intra-axonal translation of RhoA is required for growth cone collapse elicited by Semaphorin 3A (Sema3A), an axonal guidance cue. Selective knock-down of axonal RhoA mRNA abolishes Sema3A-dependent growth cone collapse " RLID00002511 11727 Ang http://www.ncbi.nlm.nih.gov/gene/?term=11727 "AI3855861, Rnase5, Rnase5a, Ang " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002512 117287 Park7 http://www.ncbi.nlm.nih.gov/gene/?term=117287 "CAP1, DJ-1, Dj1, SP22 " mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00002513 117287 Park7 http://www.ncbi.nlm.nih.gov/gene/?term=117287 "CAP1, DJ-1, Dj1, SP22 " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00002514 117294 Dsp1 http://www.ncbi.nlm.nih.gov/gene/?term=117294 "Dmel_CG12223, CG12223, DSP1, Dmel\CG12223, Hmg14B, Hmg14D, Ssrp2, dsp1, hmg, ssrp2 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00002515 117294 Dsp1 http://www.ncbi.nlm.nih.gov/gene/?term=117294 "Dmel_CG12223, CG12223, DSP1, Dmel\CG12223, Hmg14B, Hmg14D, Ssrp2, dsp1, hmg, ssrp2 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00002516 11735 Ank3 http://www.ncbi.nlm.nih.gov/gene/?term=11735 "2900054D09Rik, AI314020, Ank-3, AnkG, Ankyrin-3, Ankyrin-G " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002517 11735 Ank3 http://www.ncbi.nlm.nih.gov/gene/?term=11735 "2900054D09Rik, AI314020, Ank-3, AnkG, Ankyrin-3, Ankyrin-G " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002518 117369 Desat1 http://www.ncbi.nlm.nih.gov/gene/?term=117369 "Dmel_CG5887, BEST:SD05462, CG5887, Dmel\CG5887, Fad, anon-WO0118547.726, anon-WO0118547.730, desat, desat1, ds1, fad, l(3)S028813 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00002519 117369 Desat1 http://www.ncbi.nlm.nih.gov/gene/?term=117369 "Dmel_CG5887, BEST:SD05462, CG5887, Dmel\CG5887, Fad, anon-WO0118547.726, anon-WO0118547.730, desat, desat1, ds1, fad, l(3)S028813 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00002520 117369 Desat1 http://www.ncbi.nlm.nih.gov/gene/?term=117369 "Dmel_CG5887, BEST:SD05462, CG5887, Dmel\CG5887, Fad, anon-WO0118547.726, anon-WO0118547.730, desat, desat1, ds1, fad, l(3)S028813 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00002521 117369 Desat1 http://www.ncbi.nlm.nih.gov/gene/?term=117369 "Dmel_CG5887, BEST:SD05462, CG5887, Dmel\CG5887, Fad, anon-WO0118547.726, anon-WO0118547.730, desat, desat1, ds1, fad, l(3)S028813 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00002522 11736 Ankfy1 http://www.ncbi.nlm.nih.gov/gene/?term=11736 "Ankhzn, ZFYVE14, mKIAA1255 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002523 11737 Anp32a http://www.ncbi.nlm.nih.gov/gene/?term=11737 "Anp32, I1PP2A, LANP, PHAP1, W91701, pp32 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002524 1173 AP2M1 http://www.ncbi.nlm.nih.gov/gene/?term=1173 "AP50, CLAPM1, mu2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002525 11740 Slc25a5 http://www.ncbi.nlm.nih.gov/gene/?term=11740 Ant2 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002526 11745 Anxa3 http://www.ncbi.nlm.nih.gov/gene/?term=11745 Anx3 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00002527 1174 AP1S1 http://www.ncbi.nlm.nih.gov/gene/?term=1174 "AP19, CLAPS1, EKV3, MEDNIK, SIGMA1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002528 1174 AP1S1 http://www.ncbi.nlm.nih.gov/gene/?term=1174 "AP19, CLAPS1, EKV3, MEDNIK, SIGMA1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002529 117531 TMC1 http://www.ncbi.nlm.nih.gov/gene/?term=117531 "DFNA36, DFNB11, DFNB7 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002530 117531 TMC1 http://www.ncbi.nlm.nih.gov/gene/?term=117531 "DFNA36, DFNB11, DFNB7 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002531 117557 Tpm3 http://www.ncbi.nlm.nih.gov/gene/?term=117557 "TM30nm, Tpm5 " mRNA Rattus norvegicus 15673657 Cell body Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00002532 117557 Tpm3 http://www.ncbi.nlm.nih.gov/gene/?term=117557 "TM30nm, Tpm5 " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00002533 117584 RFFL http://www.ncbi.nlm.nih.gov/gene/?term=117584 "CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002534 117584 RFFL http://www.ncbi.nlm.nih.gov/gene/?term=117584 "CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002535 117584 RFFL http://www.ncbi.nlm.nih.gov/gene/?term=117584 "CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002536 117584 RFFL http://www.ncbi.nlm.nih.gov/gene/?term=117584 "CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002537 117584 RFFL http://www.ncbi.nlm.nih.gov/gene/?term=117584 "CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002538 117599 Helb http://www.ncbi.nlm.nih.gov/gene/?term=117599 "AI447783, D10Ertd664e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002539 1175 AP2S1 http://www.ncbi.nlm.nih.gov/gene/?term=1175 "AP17, CLAPS2, FBH3, FBHOk, HHC3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002540 1175 AP2S1 http://www.ncbi.nlm.nih.gov/gene/?term=1175 "AP17, CLAPS2, FBH3, FBHOk, HHC3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002541 11761 Aox1 http://www.ncbi.nlm.nih.gov/gene/?term=11761 "AI196512, AI255253, Ao, Aox-1, Aox-2, Aox2, Moro, Ro " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002542 11765 Ap1g1 http://www.ncbi.nlm.nih.gov/gene/?term=11765 "AA409002, AU041323, AW551707, Adtg, D8Ertd374e " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002543 1176 AP3S1 http://www.ncbi.nlm.nih.gov/gene/?term=1176 "CLAPS3, Sigma3A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002544 1176 AP3S1 http://www.ncbi.nlm.nih.gov/gene/?term=1176 "CLAPS3, Sigma3A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002545 11774 Ap3b1 http://www.ncbi.nlm.nih.gov/gene/?term=11774 "AP-3, AU015684, C78395, Hps2, beta3A, pe, pearl, rim2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002546 117852 TRIM78P http://www.ncbi.nlm.nih.gov/gene/?term=117852 TRIMP1 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002547 117854 TRIM6 http://www.ncbi.nlm.nih.gov/gene/?term=117854 RNF89 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002548 117854 TRIM6 http://www.ncbi.nlm.nih.gov/gene/?term=117854 RNF89 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002549 11787 Apbb2 http://www.ncbi.nlm.nih.gov/gene/?term=11787 "2310007D03Rik, FE65L1, Rirl1, TR2L, Zfra " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002550 11789 Apc http://www.ncbi.nlm.nih.gov/gene/?term=11789 "AI047805, AU020952, AW124434, CC1, Min, mAPC " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00002551 11797 Birc2 http://www.ncbi.nlm.nih.gov/gene/?term=11797 "AW146227, Api1, Api2, Birc3, C330006D17Rik, HIAP1, HIAP2, IAP1, IAP2, MIAP1, MIAP2, MIHB, MIHC, RNF48, cIAP1, cIAP2, mcIAP1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002552 11800 Api5 http://www.ncbi.nlm.nih.gov/gene/?term=11800 "AAC-11, AI196452, API-5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002553 11801 Cd5l http://www.ncbi.nlm.nih.gov/gene/?term=11801 "1/6, AAC-11, AI047839, Api6, CT2, Pdp, Sp-alpha, mAIM " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002554 11804 Aplp2 http://www.ncbi.nlm.nih.gov/gene/?term=11804 "AI790698, APLP-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002555 11804 Aplp2 http://www.ncbi.nlm.nih.gov/gene/?term=11804 "AI790698, APLP-2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002556 11816 Apoe http://www.ncbi.nlm.nih.gov/gene/?term=11816 "AI255918, Apo-E " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002557 11819 Nr2f2 http://www.ncbi.nlm.nih.gov/gene/?term=11819 "2700033K02Rik, 9430015G03Rik, ARP-1, Aporp1, COUP-TF2, COUP-TFII, COUPTFB, EAR3, SVP40, Tcfcoup2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002558 11820 App http://www.ncbi.nlm.nih.gov/gene/?term=11820 "Abeta, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002559 11820 App http://www.ncbi.nlm.nih.gov/gene/?term=11820 "Abeta, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002560 1182 CLCN3 http://www.ncbi.nlm.nih.gov/gene/?term=1182 "CLC3, ClC-3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002561 1182 CLCN3 http://www.ncbi.nlm.nih.gov/gene/?term=1182 "CLC3, ClC-3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002562 1182 CLCN3 http://www.ncbi.nlm.nih.gov/gene/?term=1182 "CLC3, ClC-3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002563 11837 Rplp0 http://www.ncbi.nlm.nih.gov/gene/?term=11837 "36B4, Arbp, L10E " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002564 11838 Arc http://www.ncbi.nlm.nih.gov/gene/?term=11838 "Arc3.1, C86064, arg3.1, mArc " mRNA Mus musculus 22945799 Synapse Brain RT-PCR|Immunoprecipitation "Fig. 5 a Detection of KIF1Bb in purified mouse synaptoneurosomes. KIF1Bb is detected in total lysates from the cortex (T; 5 lg total protein) and is enriched in a sample of synaptoneurosomes purified from the cortex (S; 5 lg). The analysis, by RT-PCR, revealed the presence of Arc (activity regulated cytoskeleton-associated protein) mRNA (Fig. 8c), a well-known, dendritically localized mRNA [43-45]. Interestingly, Calmodulin mRNA was also part of this complex. Both were specifically found in the KIF1Bb-immunoprecipitated complex, but not in the negative control reaction (Fig. 8c, compare lanes 2 and 3). The specific association of Arc and Calmodulin mRNAs with the KIF1Bb-containing complex is further supported by the absence of non-synaptically or other synaptically localized mRNAs such as eEIF1a and aCaMKII (Fig. 8c). These observations would suggest the participation of KIF1Bb in RNP particles in association with at least two dendritically targeted mRNAs, Arc and CaM. " RLID00002565 1183 CLCN4 http://www.ncbi.nlm.nih.gov/gene/?term=1183 "CLC4, ClC-4, ClC-4A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002566 11840 Arf1 http://www.ncbi.nlm.nih.gov/gene/?term=11840 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002567 118424 UBE2J2 http://www.ncbi.nlm.nih.gov/gene/?term=118424 "NCUBE-2, NCUBE2, PRO2121 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002568 118424 UBE2J2 http://www.ncbi.nlm.nih.gov/gene/?term=118424 "NCUBE-2, NCUBE2, PRO2121 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002569 118429 ANTXR2 http://www.ncbi.nlm.nih.gov/gene/?term=118429 "CMG-2, CMG2, HFS, ISH, JHF " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002570 118429 ANTXR2 http://www.ncbi.nlm.nih.gov/gene/?term=118429 "CMG-2, CMG2, HFS, ISH, JHF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002571 118433 RPL23AP7 http://www.ncbi.nlm.nih.gov/gene/?term=118433 "RPL23AL1, RPL23A_6_267, bA395L14.9 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002572 118445 Klf16 http://www.ncbi.nlm.nih.gov/gene/?term=118445 "AI843742, BTEB4, DRRF " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002573 11844 Arf5 http://www.ncbi.nlm.nih.gov/gene/?term=11844 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002574 11845 Arf6 http://www.ncbi.nlm.nih.gov/gene/?term=11845 "AI788669, AW496366 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002575 11845 Arf6 http://www.ncbi.nlm.nih.gov/gene/?term=11845 "AI788669, AW496366 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002576 118460 EXOSC6 http://www.ncbi.nlm.nih.gov/gene/?term=118460 "EAP4, MTR3, Mtr3p, hMtr3p, p11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002577 11846 Arg1 http://www.ncbi.nlm.nih.gov/gene/?term=11846 "AI, AI256583, Arg-1, PGIF " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002578 118472 ZNF511 http://www.ncbi.nlm.nih.gov/gene/?term=118472 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002579 11847 Arg2 http://www.ncbi.nlm.nih.gov/gene/?term=11847 "AII, AU022422 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002580 118487 CHCHD1 http://www.ncbi.nlm.nih.gov/gene/?term=118487 "C10orf34, C2360, MRP-S37 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002581 11848 Rhoa http://www.ncbi.nlm.nih.gov/gene/?term=11848 "Arha, Arha1, Arha2 " mRNA Mus musculus 20035871 Dendrite Brain RT-PCR "Using this preparation, we have found that RhoA mRNA is dendritically localized and its local translation is enhanced by BDNF stimulation. " RLID00002582 1184 CLCN5 http://www.ncbi.nlm.nih.gov/gene/?term=1184 "CLC5, CLCK2, ClC-5, DENTS, NPHL1, NPHL2, XLRH, XRN, hCIC-K2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002583 1184 CLCN5 http://www.ncbi.nlm.nih.gov/gene/?term=1184 "CLC5, CLCK2, ClC-5, DENTS, NPHL1, NPHL2, XLRH, XRN, hCIC-K2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002584 1184 CLCN5 http://www.ncbi.nlm.nih.gov/gene/?term=1184 "CLC5, CLCK2, ClC-5, DENTS, NPHL1, NPHL2, XLRH, XRN, hCIC-K2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002585 11852 Rhob http://www.ncbi.nlm.nih.gov/gene/?term=11852 "AA017882, Arh6, Arhb " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002586 11857 Arhgdib http://www.ncbi.nlm.nih.gov/gene/?term=11857 "D4, Gdid4, Ly-GDI " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002587 11859 Phox2a http://www.ncbi.nlm.nih.gov/gene/?term=11859 "Arix, Phox2, Pmx2, Pmx2a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002588 1185 CLCN6 http://www.ncbi.nlm.nih.gov/gene/?term=1185 CLC-6 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002589 11864 Arnt2 http://www.ncbi.nlm.nih.gov/gene/?term=11864 "Hif-2b, bHLHe1, mKIAA0307 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002590 1186 CLCN7 http://www.ncbi.nlm.nih.gov/gene/?term=1186 "CLC-7, CLC7, OPTA2, OPTB4, PPP1R63 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002591 11877 Arvcf http://www.ncbi.nlm.nih.gov/gene/?term=11877 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002592 118788 PIK3AP1 http://www.ncbi.nlm.nih.gov/gene/?term=118788 BCAP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002593 1187 CLCNKA http://www.ncbi.nlm.nih.gov/gene/?term=1187 "CLCK1, ClC-K1, hClC-Ka " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002594 118812 MORN4 http://www.ncbi.nlm.nih.gov/gene/?term=118812 "C10orf83, bA548K23.4, rtp " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002595 118812 MORN4 http://www.ncbi.nlm.nih.gov/gene/?term=118812 "C10orf83, bA548K23.4, rtp " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002596 118812 MORN4 http://www.ncbi.nlm.nih.gov/gene/?term=118812 "C10orf83, bA548K23.4, rtp " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002597 118813 ZFYVE27 http://www.ncbi.nlm.nih.gov/gene/?term=118813 "PROTRUDIN, SPG33 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002598 11886 Asah1 http://www.ncbi.nlm.nih.gov/gene/?term=11886 "2310081N20Rik, AC, Asah " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002599 118881 COMTD1 http://www.ncbi.nlm.nih.gov/gene/?term=118881 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002600 118924 FRA10AC1 http://www.ncbi.nlm.nih.gov/gene/?term=118924 "C10orf4, F26C11.1-like, FRA10A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002601 118980 SFXN2 http://www.ncbi.nlm.nih.gov/gene/?term=118980 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002602 118980 SFXN2 http://www.ncbi.nlm.nih.gov/gene/?term=118980 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002603 118980 SFXN2 http://www.ncbi.nlm.nih.gov/gene/?term=118980 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002604 118980 SFXN2 http://www.ncbi.nlm.nih.gov/gene/?term=118980 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002605 118987 PDZD8 http://www.ncbi.nlm.nih.gov/gene/?term=118987 PDZK8 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002606 11898 Ass1 http://www.ncbi.nlm.nih.gov/gene/?term=11898 "AA408052, ASS, Ass-1, fold " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002607 118 ADD1 http://www.ncbi.nlm.nih.gov/gene/?term=118 ADDA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002608 118 ADD1 http://www.ncbi.nlm.nih.gov/gene/?term=118 ADDA mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002609 119032 BORCS7 http://www.ncbi.nlm.nih.gov/gene/?term=119032 C10orf32 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002610 119032 BORCS7 http://www.ncbi.nlm.nih.gov/gene/?term=119032 C10orf32 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002611 11906 Zfhx3 http://www.ncbi.nlm.nih.gov/gene/?term=11906 "A230102L03Rik, Atbf1, Sci, WBP9, mKIAA4228 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002612 11906 Zfhx3 http://www.ncbi.nlm.nih.gov/gene/?term=11906 "A230102L03Rik, Atbf1, Sci, WBP9, mKIAA4228 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002613 11907 Ate1 http://www.ncbi.nlm.nih.gov/gene/?term=11907 "AI225793, AW547406 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002614 11909 Atf2 http://www.ncbi.nlm.nih.gov/gene/?term=11909 "Atf-2, CRE-BP, Creb2, D130078H02Rik, D18875, Tg(Gzma-Klra1)7Wum, mXBP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002615 11911 Atf4 http://www.ncbi.nlm.nih.gov/gene/?term=11911 "Atf-4, C/ATF, CREB2, TAXREB67 " mRNA Mus musculus 18195013 Ribosome S/S MEF cell RT-PCR "The resulting lowered eIF2-GTP levels leads to reduced polysomes and accumulation of free ribosomal subunits in the polysome profile (Fig. 8,top panels). This stress arrangement led to a shift in the ATF4 mRNA to the larger polysome fractions (Fig. 8,fractions 7-11). " RLID00002616 11911 Atf4 http://www.ncbi.nlm.nih.gov/gene/?term=11911 "Atf-4, C/ATF, CREB2, TAXREB67 " mRNA Mus musculus 26131922 Axon Brain In situ hybridization "Finally, Atf4 mRNA is found in adult axons of mice and human brains in the context of Abeta-induced neurodegeneration. " RLID00002617 1191 CLU http://www.ncbi.nlm.nih.gov/gene/?term=1191 "AAG4, APO-J, APOJ, CLI1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, CLU " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002618 1191 CLU http://www.ncbi.nlm.nih.gov/gene/?term=1191 "AAG4, APO-J, APOJ, CLI1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, CLU " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002619 1191 CLU http://www.ncbi.nlm.nih.gov/gene/?term=1191 "AAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002620 11920 Atm http://www.ncbi.nlm.nih.gov/gene/?term=11920 "AI256621, C030026E19Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002621 11921 Atoh1 http://www.ncbi.nlm.nih.gov/gene/?term=11921 "Hath1, MATH-1, Math1, bHLHa14 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002622 11922 Neurod6 http://www.ncbi.nlm.nih.gov/gene/?term=11922 "Atoh2, Math-2, Math2, Nex, Nex1m, bHLHa2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002623 11927 Atox1 http://www.ncbi.nlm.nih.gov/gene/?term=11927 "AI256639, Atx1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002624 1192 CLIC1 http://www.ncbi.nlm.nih.gov/gene/?term=1192 "G6, NCC27 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002625 1192 CLIC1 http://www.ncbi.nlm.nih.gov/gene/?term=1192 "G6, NCC27 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002626 1192 CLIC1 http://www.ncbi.nlm.nih.gov/gene/?term=1192 "G6, NCC27 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002627 11933 Atp1b3 http://www.ncbi.nlm.nih.gov/gene/?term=11933 "AA409958, AI664000, AW212096 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002628 119391 GSTO2 http://www.ncbi.nlm.nih.gov/gene/?term=119391 "GSTO 2-2, bA127L20.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002629 1193 CLIC2 http://www.ncbi.nlm.nih.gov/gene/?term=1193 "CLIC2b, MRXS32, XAP121 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002630 119467 CLRN3 http://www.ncbi.nlm.nih.gov/gene/?term=119467 "TMEM12, USH3AL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002631 119504 ANAPC16 http://www.ncbi.nlm.nih.gov/gene/?term=119504 "APC16, C10orf104, CENP-27, MSAG, bA570G20.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002632 119504 ANAPC16 http://www.ncbi.nlm.nih.gov/gene/?term=119504 "APC16, C10orf104, CENP-27, MSAG, bA570G20.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002633 11950 Atp5f1 http://www.ncbi.nlm.nih.gov/gene/?term=11950 C76477 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002634 119587 CPXM2 http://www.ncbi.nlm.nih.gov/gene/?term=119587 "CPX2, UNQ676 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002635 119587 CPXM2 http://www.ncbi.nlm.nih.gov/gene/?term=119587 "CPX2, UNQ676 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002636 1195 CLK1 http://www.ncbi.nlm.nih.gov/gene/?term=1195 "CLK, CLK/STY, STY " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002637 11964 Atp6v1a http://www.ncbi.nlm.nih.gov/gene/?term=11964 "AI647066, Atp6a1, Atp6a21, VA68, VPP2, Atp6v1a " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002638 11966 Atp6v1b2 http://www.ncbi.nlm.nih.gov/gene/?term=11966 "AI194269, AI790362, Atp6b2, HO57, R74844 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002639 1196 CLK2 http://www.ncbi.nlm.nih.gov/gene/?term=1196 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002640 11977 Atp7a http://www.ncbi.nlm.nih.gov/gene/?term=11977 MNK mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002641 11980 Atp8a1 http://www.ncbi.nlm.nih.gov/gene/?term=11980 "AI481521, AI853962, APLT, AW743152, AW822227, Atp3a2, B230107D19Rik, ClassI " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002642 11983 Atpif1 http://www.ncbi.nlm.nih.gov/gene/?term=11983 "Atpi, IF(1), If1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002643 11984 Atp6v0c http://www.ncbi.nlm.nih.gov/gene/?term=11984 "Atp6c, Atp6c2, Atp6l, Atpl, Atpl-rs1, PL16, VATL, Vma3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002644 11987 Slc7a1 http://www.ncbi.nlm.nih.gov/gene/?term=11987 "4831426K01Rik, AI447493, Atrc-1, Atrc1, Cat1, Rec-1, Rev-1, mCAT-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002645 11988 Slc7a2 http://www.ncbi.nlm.nih.gov/gene/?term=11988 "20.5, AI158848, Atrc2, CAT-2, Cat2, Tea " mRNA Mus musculus 16239143 Nucleus NIH 3T3 cell Fluorescence in situ hybridization "We have identified CTN-RNA, a mouse tissue-specific approximately 8 kb nuclear-retained poly(A)+ RNA that regulates the level of its protein-coding partner. CTN-RNA is transcribed from the protein-coding mouse cationic amino acid transporter 2 (mCAT2) gene through alternative promoter and poly(A) site usage. CTN-RNA is diffusely distributed in nuclei and is also localized to paraspeckles. " RLID00002646 1198 CLK3 http://www.ncbi.nlm.nih.gov/gene/?term=1198 "PHCLK3, PHCLK3/152 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002647 1198 CLK3 http://www.ncbi.nlm.nih.gov/gene/?term=1198 "PHCLK3, PHCLK3/152 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002648 11990 Atrn http://www.ncbi.nlm.nih.gov/gene/?term=11990 "AW558010, Mgca, mKIAA0548, mahogany, mg " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002649 11997 Akr1b7 http://www.ncbi.nlm.nih.gov/gene/?term=11997 "AR, Avdp, MVDP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002650 119 ADD2 http://www.ncbi.nlm.nih.gov/gene/?term=119 ADDB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002651 120071 GYLTL1B http://www.ncbi.nlm.nih.gov/gene/?term=120071 "LARGE2, PP5656 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002652 1200 TPP1 http://www.ncbi.nlm.nih.gov/gene/?term=1200 "CLN2, GIG1, LPIC, SCAR7, TPP-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002653 1200 TPP1 http://www.ncbi.nlm.nih.gov/gene/?term=1200 "CLN2, GIG1, LPIC, SCAR7, TPP-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002654 120103 SLC36A4 http://www.ncbi.nlm.nih.gov/gene/?term=120103 PAT4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002655 12010 B2m http://www.ncbi.nlm.nih.gov/gene/?term=12010 "Ly-m11, beta2-m, beta2m " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002656 12013 Bach1 http://www.ncbi.nlm.nih.gov/gene/?term=12013 "6230421P05Rik, AI323795 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002657 12014 Bach2 http://www.ncbi.nlm.nih.gov/gene/?term=12014 E030004N02Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002658 12015 Bad http://www.ncbi.nlm.nih.gov/gene/?term=12015 "AI325008, Bbc2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002659 12018 Bak1 http://www.ncbi.nlm.nih.gov/gene/?term=12018 "Bak, N-BAK1, N-Bak " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002660 1201 CLN3 http://www.ncbi.nlm.nih.gov/gene/?term=1201 "BTS, JNCL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002661 120224 TMEM45B http://www.ncbi.nlm.nih.gov/gene/?term=120224 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002662 120227 CYP2R1 http://www.ncbi.nlm.nih.gov/gene/?term=120227 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002663 120227 CYP2R1 http://www.ncbi.nlm.nih.gov/gene/?term=120227 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002664 12033 Bcap29 http://www.ncbi.nlm.nih.gov/gene/?term=12033 "AW208404, Bap29 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002665 12036 Bcat2 http://www.ncbi.nlm.nih.gov/gene/?term=12036 "Bcat-2, Eca40 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002666 12039 Bckdha http://www.ncbi.nlm.nih.gov/gene/?term=12039 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002667 1203 CLN5 http://www.ncbi.nlm.nih.gov/gene/?term=1203 NCL mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002668 12041 Bckdk http://www.ncbi.nlm.nih.gov/gene/?term=12041 AI327402 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002669 120425 JAML http://www.ncbi.nlm.nih.gov/gene/?term=120425 "AMICA, AMICA1, CREA7-1, CREA7-4, Gm638 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002670 12043 Bcl2 http://www.ncbi.nlm.nih.gov/gene/?term=12043 "AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002671 120526 DNAJC24 http://www.ncbi.nlm.nih.gov/gene/?term=120526 "DPH4, JJJ3, ZCSL3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002672 12064 Bdnf http://www.ncbi.nlm.nih.gov/gene/?term=12064 mRNA Mus musculus 18614020 Dendrite Neuron In situ hybridization "In a mouse mutant where the long 3' UTR is truncated, dendritic targeting of BDNF mRNAs is impaired. " RLID00002673 12064 Bdnf http://www.ncbi.nlm.nih.gov/gene/?term=12064 mRNA Mus musculus 25692578 Dendrite Hippocampus Fluorescence in situ hybridization "We demonstrate that the neuronal ELAV family of RNA binding proteins associates in vivo with several Bdnf mRNA isoforms present in the adult brain in an activity-dependent manner, and that one member, HuD, interacts directly with sequences in the long Bdnf 3' untranslated region (3'UTR) and co-localizes with Bdnf mRNA in dendrites of hippocampal neurons. " RLID00002674 1207 CLNS1A http://www.ncbi.nlm.nih.gov/gene/?term=1207 "CLCI, CLNS1B, ICln " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002675 1207 CLNS1A http://www.ncbi.nlm.nih.gov/gene/?term=1207 "CLCI, CLNS1B, ICln " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002676 1207 CLNS1A http://www.ncbi.nlm.nih.gov/gene/?term=1207 "CLCI, CLNS1B, ICln " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002677 1209 CLPTM1 http://www.ncbi.nlm.nih.gov/gene/?term=1209 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002678 1209 CLPTM1 http://www.ncbi.nlm.nih.gov/gene/?term=1209 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002679 1209 CLPTM1 http://www.ncbi.nlm.nih.gov/gene/?term=1209 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002680 120 ADD3 http://www.ncbi.nlm.nih.gov/gene/?term=120 ADDL mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002681 120 ADD3 http://www.ncbi.nlm.nih.gov/gene/?term=120 ADDL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002682 121053 C12orf45 http://www.ncbi.nlm.nih.gov/gene/?term=121053 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002683 121053 C12orf45 http://www.ncbi.nlm.nih.gov/gene/?term=121053 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002684 12116 Bhmt http://www.ncbi.nlm.nih.gov/gene/?term=12116 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002685 1211 CLTA http://www.ncbi.nlm.nih.gov/gene/?term=1211 LCA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002686 1211 CLTA http://www.ncbi.nlm.nih.gov/gene/?term=1211 LCA mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002687 12121 Bicd1 http://www.ncbi.nlm.nih.gov/gene/?term=12121 B830009D06Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002688 12123 Hrk http://www.ncbi.nlm.nih.gov/gene/?term=12123 "AI838259, Bid3, DP5, harakiri " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002689 12124 Bik http://www.ncbi.nlm.nih.gov/gene/?term=12124 "Biklk, Blk, Nbk " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002690 121260 SLC15A4 http://www.ncbi.nlm.nih.gov/gene/?term=121260 "FP12591, PHT1, PTR4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002691 121274 ZNF641 http://www.ncbi.nlm.nih.gov/gene/?term=121274 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002692 1212 CLTB http://www.ncbi.nlm.nih.gov/gene/?term=1212 LCB mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002693 1212 CLTB http://www.ncbi.nlm.nih.gov/gene/?term=1212 LCB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002694 1213 CLTC http://www.ncbi.nlm.nih.gov/gene/?term=1213 "CHC, CHC17, CLH-17L2, Hc, CLTC " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002695 1213 CLTC http://www.ncbi.nlm.nih.gov/gene/?term=1213 "CHC, CHC17, CLH-17, CLTCL2, Hc " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002696 12142 Prdm1 http://www.ncbi.nlm.nih.gov/gene/?term=12142 "Blimp-1, Blimp1, PRDI-BF1, ZNFPR1A1, b2b1765Clo " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002697 121441 NEDD1 http://www.ncbi.nlm.nih.gov/gene/?term=121441 "GCP-WD, TUBGCP7 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002698 12144 Blm http://www.ncbi.nlm.nih.gov/gene/?term=12144 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002699 121457 IKBIP http://www.ncbi.nlm.nih.gov/gene/?term=121457 IKIP mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002700 121457 IKBIP http://www.ncbi.nlm.nih.gov/gene/?term=121457 IKIP mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002701 121504 HIST4H4 http://www.ncbi.nlm.nih.gov/gene/?term=121504 H4/p mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002702 121506 ERP27 http://www.ncbi.nlm.nih.gov/gene/?term=121506 "C12orf46, PDIA8 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002703 121506 ERP27 http://www.ncbi.nlm.nih.gov/gene/?term=121506 "C12orf46, PDIA8 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002704 12151 Bmi1 http://www.ncbi.nlm.nih.gov/gene/?term=12151 "AW546694, Bmi-1, Pcgf4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002705 12153 Bmp1 http://www.ncbi.nlm.nih.gov/gene/?term=12153 "Pcp, Tld " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002706 12161 Bmp6 http://www.ncbi.nlm.nih.gov/gene/?term=12161 "D13Wsu115e, Vgr1 " mRNA Mus musculus 9856831 Cell leading edge Skin - "Protein was confined to outermost suprabasal epidermal layers, whereas BMP-6-specific RNA was distributed throughout all epidermal layers including basal keratinocytes and the leading edge of the migrating keratinocytes. " RLID00002707 121642 ALKBH2 http://www.ncbi.nlm.nih.gov/gene/?term=121642 ABH2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002708 121665 SPPL3 http://www.ncbi.nlm.nih.gov/gene/?term=121665 "IMP2, MDHV1887, PRO4332, PSH1, PSL4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002709 12166 Bmpr1a http://www.ncbi.nlm.nih.gov/gene/?term=12166 "1110037I22Rik, ALK3, AU045487, BMPR-IA, Bmpr " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002710 12168 Bmpr2 http://www.ncbi.nlm.nih.gov/gene/?term=12168 "2610024H22Rik, AL117858, AW546137, BB189135, BMP-2, BMPR-2, BMPR-II, BMPRII, BRK-3, Gm20272 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002711 12168 Bmpr2 http://www.ncbi.nlm.nih.gov/gene/?term=12168 "2610024H22Rik, AL117858, AW546137, BB189135, BMP-2, BMPR-2, BMPR-II, BMPRII, BRK-3, Gm20272 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002712 12176 Bnip3 http://www.ncbi.nlm.nih.gov/gene/?term=12176 Nip3 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00002713 12177 Bnip3l http://www.ncbi.nlm.nih.gov/gene/?term=12177 "C86132, D14Ertd719e, Nip3L, Nix " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002714 12180 Smyd1 http://www.ncbi.nlm.nih.gov/gene/?term=12180 "4632404M21Rik, Bop, C78565, Zmynd18 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002715 12189 Brca1 http://www.ncbi.nlm.nih.gov/gene/?term=12189 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002716 12193 Zfp36l2 http://www.ncbi.nlm.nih.gov/gene/?term=12193 "Brf2, ERF2, Tis11d " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002717 12211 Birc6 http://www.ncbi.nlm.nih.gov/gene/?term=12211 "A430032G04Rik, A430040A19Rik, AA501170, Bruce, D630005A10Rik, mKIAA1289 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002718 12211 Birc6 http://www.ncbi.nlm.nih.gov/gene/?term=12211 "A430032G04Rik, A430040A19Rik, AA501170, Bruce, D630005A10Rik, mKIAA1289 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002719 12223 Btc http://www.ncbi.nlm.nih.gov/gene/?term=12223 Bcn mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002720 12238 Commd3 http://www.ncbi.nlm.nih.gov/gene/?term=12238 "AW550818, Bup, D2Ertd542e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002721 122416 ANKRD9 http://www.ncbi.nlm.nih.gov/gene/?term=122416 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002722 122509 IFI27L1 http://www.ncbi.nlm.nih.gov/gene/?term=122509 "FAM14B, ISG12C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002723 122509 IFI27L1 http://www.ncbi.nlm.nih.gov/gene/?term=122509 "FAM14B, ISG12C " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002724 122553 TRAPPC6B http://www.ncbi.nlm.nih.gov/gene/?term=122553 TPC6 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002725 12257 Tspo http://www.ncbi.nlm.nih.gov/gene/?term=12257 "Bzrp, IBP, PBR1, Tspo " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002726 122622 ADSSL1 http://www.ncbi.nlm.nih.gov/gene/?term=122622 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002727 12265 Ciita http://www.ncbi.nlm.nih.gov/gene/?term=12265 "C2ta, EG669998, Gm9475, Mhc2ta " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002728 122704 MRPL52 http://www.ncbi.nlm.nih.gov/gene/?term=122704 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002729 122769 LRR1 http://www.ncbi.nlm.nih.gov/gene/?term=122769 "4-1BBLRR, LRR-1, PPIL5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002730 122809 SOCS4 http://www.ncbi.nlm.nih.gov/gene/?term=122809 SOCS7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002731 122830 NAA30 http://www.ncbi.nlm.nih.gov/gene/?term=122830 "C14orf35, MAK3, Mak3p, NAT12, NAT12P " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002732 122830 NAA30 http://www.ncbi.nlm.nih.gov/gene/?term=122830 "C14orf35, MAK3, Mak3p, NAT12, NAT12P " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002733 12283 Cab39 http://www.ncbi.nlm.nih.gov/gene/?term=12283 "AA408805, AA960512, C78372, MO25, MO25alpha " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002734 12290 Cacna1e http://www.ncbi.nlm.nih.gov/gene/?term=12290 "A430040I15, BII, Cach6, Cacnl1a6, Cav2.3, Cchra1, alpha1E " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002735 12293 Cacna2d1 http://www.ncbi.nlm.nih.gov/gene/?term=12293 "Ca(v)alpha2delta1, Cacna2, Cchl2a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002736 122953 JDP2 http://www.ncbi.nlm.nih.gov/gene/?term=122953 JUNDM2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002737 122953 JDP2 http://www.ncbi.nlm.nih.gov/gene/?term=122953 JUNDM2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002738 12295 Cacnb1 http://www.ncbi.nlm.nih.gov/gene/?term=12295 "CAB1, Cchb1, Cchlb1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002739 122961 ISCA2 http://www.ncbi.nlm.nih.gov/gene/?term=122961 "HBLD1, ISA2, MMDS4, c14_5557 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002740 122961 ISCA2 http://www.ncbi.nlm.nih.gov/gene/?term=122961 "HBLD1, ISA2, MMDS4, c14_5557 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002741 12300 Cacng2 http://www.ncbi.nlm.nih.gov/gene/?term=12300 "AW060990, B230105C07Rik, B930041E13Rik, stargazer, stargazin, stg, wag, waggler " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002742 123036 TC2N http://www.ncbi.nlm.nih.gov/gene/?term=123036 "C14orf47, C2CD1, MTAC2D1, Tac2-N " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002743 12304 Pdia4 http://www.ncbi.nlm.nih.gov/gene/?term=12304 "AI987846, Cai, ERp-72, Erp72 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002744 12306 Anxa2 http://www.ncbi.nlm.nih.gov/gene/?term=12306 "AW215814, Cal1h " mRNA Mus musculus 24152552 Axon Motorneuron RT-PCR Two mRNAs (Anxa2 and Cox4i2) colocalize with the SMN protein in axons from differentiated NSC-34 cells and that their axonal localization is dramatically reduced in SMN-deficient cells RLID00002745 12306 Anxa2 http://www.ncbi.nlm.nih.gov/gene/?term=12306 "AW215814, Cal1h " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00002746 12307 Calb1 http://www.ncbi.nlm.nih.gov/gene/?term=12307 "Brain-2, CB, Calb, Calb-1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002747 12307 Calb1 http://www.ncbi.nlm.nih.gov/gene/?term=12307 "Brain-2, CB, Calb, Calb-1 " mRNA Mus musculus 9387927 Cell body Purkinje cell In situ hybridizationq|Immunocytochemistry "Whereas calbindin mRNA was found to be in the cell body only, L7 transcripts could be detected within the molecular layer, corresponding to Purkinje cell dendrites. " RLID00002748 12308 Calb2 http://www.ncbi.nlm.nih.gov/gene/?term=12308 CR mRNA Mus musculus 9387927 Cell body Purkinje cell In situ hybridizationq|Immunocytochemistry "Whereas calbindin mRNA was found to be in the cell body only, L7 transcripts could be detected within the molecular layer, corresponding to Purkinje cell dendrites. " RLID00002749 123096 SLC25A29 http://www.ncbi.nlm.nih.gov/gene/?term=123096 "C14orf69, CACL, ORNT3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002750 123096 SLC25A29 http://www.ncbi.nlm.nih.gov/gene/?term=123096 "C14orf69, CACL, ORNT3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002751 123099 DEGS2 http://www.ncbi.nlm.nih.gov/gene/?term=123099 "C14orf66, DES2, FADS8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002752 12313 Calm1 http://www.ncbi.nlm.nih.gov/gene/?term=12313 "AI256814, AI327027, AI461935, AL024000, CaM, Calm " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002753 12313 Calm1 http://www.ncbi.nlm.nih.gov/gene/?term=12313 "AI256814, AI327027, AI461935, AL024000, CaM, Calm " mRNA Mus musculus 22945799 Synapse Brain RT-PCR|Immunoprecipitation "Fig. 5 a Detection of KIF1Bb in purified mouse synaptoneurosomes. KIF1Bb is detected in total lysates from the cortex (T; 5 lg total protein) and is enriched in a sample of synaptoneurosomes purified from the cortex (S; 5 lg). The analysis, by RT-PCR, revealed the presence of Arc (activity regulated cytoskeleton-associated protein) mRNA (Fig. 8c), a well-known, dendritically localized mRNA [43-45]. Interestingly, Calmodulin mRNA was also part of this complex. Both were specifically found in the KIF1Bb-immunoprecipitated complex, but not in the negative control reaction (Fig. 8c, compare lanes 2 and 3). The specific association of Arc and Calmodulin mRNAs with the KIF1Bb-containing complex is further supported by the absence of non-synaptically or other synaptically localized mRNAs such as eEIF1a and aCaMKII (Fig. 8c). These observations would suggest the participation of KIF1Bb in RNP particles in association with at least two dendritically targeted mRNAs, Arc and CaM. " RLID00002754 12315 Calm3 http://www.ncbi.nlm.nih.gov/gene/?term=12315 "CaMA, R75142 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002755 123169 LEO1 http://www.ncbi.nlm.nih.gov/gene/?term=123169 RDL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002756 12316 Aspm http://www.ncbi.nlm.nih.gov/gene/?term=12316 "Calmbp1, D330028K02Rik, MCPH5, Sha1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002757 12317 Calr http://www.ncbi.nlm.nih.gov/gene/?term=12317 "CRTegulin, Calr " mRNA Mus musculus 12923260 Endoplasmic reticulum B cell S1 nuclease protection assays "Oligonucleotide probes were designed to hybridize with mRNAs encoding representative members of three classes of protein: soluble (GAPDH, Hsp90, and LDH), ER resident membrane (Sec61a and calnexin), and ER resident lumenal (BiP, calreticulin, and GRP94). " RLID00002758 12317 Calr http://www.ncbi.nlm.nih.gov/gene/?term=12317 "CRTegulin, Calr " mRNA Mus musculus 12923260 Ribosome B cell S1 nuclease protection assays "Using the procedures described above, the subcellular distribution of individual mRNAs in the cytosol and rough ER polysome fractions of Jurkat and J558 cells was determined. mRNAs for resident proteins of the ER lumen, including BiP, calreticulin, and GRP94, were also highly enriched on membrane-bound polysomes. " RLID00002759 12317 Calr http://www.ncbi.nlm.nih.gov/gene/?term=12317 "CRT, Calregulin " mRNA Mus musculus 12923260 Ribosome J558 cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00002760 123207 C15orf40 http://www.ncbi.nlm.nih.gov/gene/?term=123207 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002761 12321 Calu http://www.ncbi.nlm.nih.gov/gene/?term=12321 9530075H20Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002762 123228 SENP8 http://www.ncbi.nlm.nih.gov/gene/?term=123228 "DEN1, NEDP1, PRSC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002763 12322 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=12322 "CaMKII, R74975, mKIAA0968 " mRNA Mus musculus 18539120 Dendrite Neuron Fluorescence in situ hybridization Figure 5c: Dendritic CaMKIIa mRNA localization in response to DHPG (11DIV). RLID00002764 12322 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=12322 "CaMKII, R74975, mKIAA0968 " mRNA Mus musculus 18539120 Synapse Brain qRT-PCR "The mRNA targets reduced in Kif5 association included genes involved in actin remodeling at synapses (cofilin phosphatase (PP2Ac); p116-RIP), synapse-associated signaling (DAG1;RGS5) and synapse structure (SAPAP4; CaMKIIa; MAP1b). Not all mRNAs were significantly reduced in Kif5 IPs, as OCRL1 mRNA was similar in KO brain (P>0.05, n=8). " RLID00002765 12322 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=12322 "CaMKII, R74975, mKIAA0968 " mRNA Mus musculus 20713728 Dendrite Hippocampus Fluorescence in situ hybridization "Moreover, in WT neurons, CaMKIIα mRNA can be delivered and translated in dendritic spines within 10 min in response to group I mGluR stimulation, whereas KO neurons fail to show this response. CaMKIIα mRNAs and protein synthesis were more enriched at dendritic spines in WT but not fmr1 KO neurons. " RLID00002766 12322 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=12322 "CaMKII, R74975, mKIAA0968 " mRNA Mus musculus 22768241 Dendrite Granule cell qRT-PCR|Fluorescence in situ hybridization "Through in situ hybridization and synaptosome preparation, we show that CaMKIIα mRNA is transported in GC dendrites, synaptically localized and might be locally translated at GC synapses. " RLID00002767 12322 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=12322 "CaMKII, R74975, mKIAA0968 " mRNA Mus musculus 22768241 Synapse Granule cell qRT-PCR|Fluorescence in situ hybridization "Taken together, these results strongly suggest that CaMKIIα mRNA is dendritically and synaptically localized in GCs. Through in situ hybridization and synaptosome preparation, we show that CaMKIIα mRNA is transported in GC dendrites, synaptically localized and might be locally translated at GC synapses. " RLID00002768 12322 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=12322 "CaMKII, R74975, mKIAA0968 " mRNA Mus musculus 22945799 Synapse Brain RT-PCR|Immunoprecipitation "Fig. 5 a Detection of KIF1Bb in purified mouse synaptoneurosomes. KIF1Bb is detected in total lysates from the cortex (T; 5 lg total protein) and is enriched in a sample of synaptoneurosomes purified from the cortex (S; 5 lg). The analysis, by RT-PCR, revealed the presence of Arc (activity regulated cytoskeleton-associated protein) mRNA (Fig. 8c), a well-known, dendritically localized mRNA [43-45]. Interestingly, Calmodulin mRNA was also part of this complex. Both were specifically found in the KIF1Bb-immunoprecipitated complex, but not in the negative control reaction (Fig. 8c, compare lanes 2 and 3). The specific association of Arc and Calmodulin mRNAs with the KIF1Bb-containing complex is further supported by the absence of non-synaptically or other synaptically localized mRNAs such as eEIF1a and aCaMKII (Fig. 8c). These observations would suggest the participation of KIF1Bb in RNP particles in association with at least two dendritically targeted mRNAs, Arc and CaM. " RLID00002769 12322 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=12322 "CaMKII, R74975, mKIAA0968 " mRNA Mus musculus 24671994 Synapse - Fluorescence in situ hybridization "However, aCaMKII mRNA does localize to activated synapses, indicating that there is mRNA transport to activated synapses but that the mRNA degradation mechanism is selective for Arc. " RLID00002770 12322 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=12322 "CaMKII, R74975, mKIAA0968 " mRNA Mus musculus 26512708 Axon ForeBrain Immunoprecipitation|RIP-Chip "HuD has also been implicated in axonal localization of other neuronal mRNAs including Tau, Neuritin/CPG15, Kv.1.1 and CaMKIIα mRNAs " RLID00002771 12322 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=12322 "CaMKII, R74975, mKIAA0968 " mRNA Mus musculus 18410515 Synapse ForeBrain qRT-PCR "We noted that levels of all RNAs measured, including ribosomal 18S RNA, U6, CAMK2a and BC1, as well as mature microRNAs and their precursors, were lower in synaptosomes relative to that observed in synaptoneurosomes. " RLID00002772 123263 MTFMT http://www.ncbi.nlm.nih.gov/gene/?term=123263 "COXPD15, FMT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002773 123263 MTFMT http://www.ncbi.nlm.nih.gov/gene/?term=123263 "COXPD15, FMT1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002774 123263 MTFMT http://www.ncbi.nlm.nih.gov/gene/?term=123263 "COXPD15, FMT1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002775 123264 SLC51B http://www.ncbi.nlm.nih.gov/gene/?term=123264 "OSTB, OSTBETA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002776 12330 Canx http://www.ncbi.nlm.nih.gov/gene/?term=12330 "1110069N15Rik, AI988026, Cnx, D11Ertd153e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002777 12330 Canx http://www.ncbi.nlm.nih.gov/gene/?term=12330 "1110069N15Rik, AI988026, Cnx, D11Ertd153e " mRNA Mus musculus 12923260 Endoplasmic reticulum B cell S1 nuclease protection assays "Oligonucleotide probes were designed to hybridize with mRNAs encoding representative members of three classes of protein: soluble (GAPDH, Hsp90, and LDH), ER resident membrane (Sec61a and calnexin), and ER resident lumenal (BiP, calreticulin, and GRP94). " RLID00002778 12330 Canx http://www.ncbi.nlm.nih.gov/gene/?term=12330 "1110069N15Rik, AI988026, Cnx, D11Ertd153e " mRNA Mus musculus 12923260 Ribosome B cell S1 nuclease protection assays "Using the procedures described above, the subcellular distribution of individual mRNAs in the cytosol and rough ER polysome fractions of Jurkat and J558 cells was determined. As depicted in Figure 4, Sec61a and calnexin were highly enriched in the membrane-bound fraction, as may be predicted for those mRNAs encoding signal sequences. " RLID00002779 12330 Canx http://www.ncbi.nlm.nih.gov/gene/?term=12330 "Cnx, AI988026, D11Ertd153e, 1110069N15Rik " mRNA Mus musculus 12923260 Ribosome J558 cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00002780 123355 LRRC28 http://www.ncbi.nlm.nih.gov/gene/?term=123355 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002781 123355 LRRC28 http://www.ncbi.nlm.nih.gov/gene/?term=123355 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002782 12338 Capn6 http://www.ncbi.nlm.nih.gov/gene/?term=12338 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002783 12339 Capn7 http://www.ncbi.nlm.nih.gov/gene/?term=12339 "AU022319, PalBH " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002784 12343 Capza2 http://www.ncbi.nlm.nih.gov/gene/?term=12343 "1110053K06Rik, AW208808, Cappa2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002785 12349 Car2 http://www.ncbi.nlm.nih.gov/gene/?term=12349 "AI131712, CAII, Ca2, Car-2, Ltw-5, Lvtw-5 " mRNA Mus musculus 20820888 Cytosol Gland tissue qRT-PCR "In the present study, we examined the mRNA expression of all 13 enzymatically active CA isozymes by qRT-PCR in the mouse harderian gland. As shown in Fig. 1, nine of the 13 isozymes were detected in the harderian gland tissue at the mRNA level. Four isoforms were cytosolic (Car2, Car3, Car7, and Car13), three were membrane-associated (Car4, Car12, and Car15), one was mitochondrial (Car5b), and one was secreted (Car6). " RLID00002786 12350 Car3 http://www.ncbi.nlm.nih.gov/gene/?term=12350 "BB219044, Ca3, Car-3 " mRNA Mus musculus 20820888 Cytosol Gland tissue qRT-PCR "In the present study, we examined the mRNA expression of all 13 enzymatically active CA isozymes by qRT-PCR in the mouse harderian gland. As shown in Fig. 1, nine of the 13 isozymes were detected in the harderian gland tissue at the mRNA level. Four isoforms were cytosolic (Car2, Car3, Car7, and Car13), three were membrane-associated (Car4, Car12, and Car15), one was mitochondrial (Car5b), and one was secreted (Car6). " RLID00002787 12354 Car7 http://www.ncbi.nlm.nih.gov/gene/?term=12354 "AV343731, Ca7 " mRNA Mus musculus 20820888 Cytosol Gland tissue qRT-PCR "In the present study, we examined the mRNA expression of all 13 enzymatically active CA isozymes by qRT-PCR in the mouse harderian gland. As shown in Fig. 1, nine of the 13 isozymes were detected in the harderian gland tissue at the mRNA level. Four isoforms were cytosolic (Car2, Car3, Car7, and Car13), three were membrane-associated (Car4, Car12, and Car15), one was mitochondrial (Car5b), and one was secreted (Car6). " RLID00002788 12361 Cask http://www.ncbi.nlm.nih.gov/gene/?term=12361 "DXPri1, DXRib1, LIN-2, Pals3, mLin-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002789 12364 Casp12 http://www.ncbi.nlm.nih.gov/gene/?term=12364 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002790 12367 Casp3 http://www.ncbi.nlm.nih.gov/gene/?term=12367 "A830040C14Rik, AC-3, CASP-3, CC3, CPP-32, CPP32, Lice, SCA-1, Yama, mldy " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002791 12370 Casp8 http://www.ncbi.nlm.nih.gov/gene/?term=12370 "CASP-8, FLICE, MACH, Mch5 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002792 123720 WHAMM http://www.ncbi.nlm.nih.gov/gene/?term=123720 "WHAMM1, WHDC1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002793 123720 WHAMM http://www.ncbi.nlm.nih.gov/gene/?term=123720 "WHAMM1, WHDC1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002794 123803 NTAN1 http://www.ncbi.nlm.nih.gov/gene/?term=123803 "PNAA, PNAD " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002795 123811 FOPNL http://www.ncbi.nlm.nih.gov/gene/?term=123811 "C16orf63, FOR20, PHSECRG2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002796 123811 FOPNL http://www.ncbi.nlm.nih.gov/gene/?term=123811 "C16orf63, FOR20, PHSECRG2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002797 123811 FOPNL http://www.ncbi.nlm.nih.gov/gene/?term=123811 "C16orf63, FOR20, PHSECRG2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002798 12385 Ctnna1 http://www.ncbi.nlm.nih.gov/gene/?term=12385 "2010010M04Rik, AA517462, AI988031, Catna1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002799 123872 DNAAF1 http://www.ncbi.nlm.nih.gov/gene/?term=123872 "CILD13, LRRC50, ODA7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002800 12387 Ctnnb1 http://www.ncbi.nlm.nih.gov/gene/?term=12387 "Bfc, Catnb, Mesc " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002801 1238 ACKR2 http://www.ncbi.nlm.nih.gov/gene/?term=1238 "CCBP2, CCR10, CCR9, CMKBR9, D6, hD6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002802 1238 ACKR2 http://www.ncbi.nlm.nih.gov/gene/?term=1238 "CCBP2, CCR10, CCR9, CMKBR9, D6, hD6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002803 12391 Cav3 http://www.ncbi.nlm.nih.gov/gene/?term=12391 "AI385751, Cav-3, M-cav " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002804 123920 CMTM3 http://www.ncbi.nlm.nih.gov/gene/?term=123920 "BNAS2, CKLFSF3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002805 12394 Runx1 http://www.ncbi.nlm.nih.gov/gene/?term=12394 "AML1, CBF-alpha-2, Cbfa2, Pebp2a2, Pebpa2b " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002806 12395 Runx1t1 http://www.ncbi.nlm.nih.gov/gene/?term=12395 "Cbfa2t1h, ETO, MTG8 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002807 12398 Cbfa2t3 http://www.ncbi.nlm.nih.gov/gene/?term=12398 "A630044F12Rik, AI465270, AW229127h, ETO-2, Eto2, MTGR2, Cbfa2t3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002808 123 PLIN2 http://www.ncbi.nlm.nih.gov/gene/?term=123 "ADFP, ADRP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002809 124044 SPATA2L http://www.ncbi.nlm.nih.gov/gene/?term=124044 "C16orf76, tamo " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002810 124044 SPATA2L http://www.ncbi.nlm.nih.gov/gene/?term=124044 "C16orf76, tamo " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002811 124045 SPATA33 http://www.ncbi.nlm.nih.gov/gene/?term=124045 C16orf55 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002812 124056 NOXO1 http://www.ncbi.nlm.nih.gov/gene/?term=124056 "P41NOX, P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002813 12405 Cbln2 http://www.ncbi.nlm.nih.gov/gene/?term=12405 "6330593N19Rik, A730004O05 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002814 12411 Cbs http://www.ncbi.nlm.nih.gov/gene/?term=12411 "AI047524, AI303044, HIP4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002815 12412 Cbx1 http://www.ncbi.nlm.nih.gov/gene/?term=12412 "Cbx, Cbx-rs2, E430007M08Rik, HP1B, Hp1beta, M31, MOD1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002816 12417 Cbx3 http://www.ncbi.nlm.nih.gov/gene/?term=12417 "HP1g, M32 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002817 12419 Cbx5 http://www.ncbi.nlm.nih.gov/gene/?term=12419 "2610029O15Rik, C75991, HP1, Hp1a, Hp1alpha " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002818 1241 LTB4R http://www.ncbi.nlm.nih.gov/gene/?term=1241 "BLT1, BLTR, CMKRL1, GPR161, LTBR1, P2RY7, P2Y7, LTB4R " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002819 1241 LTB4R http://www.ncbi.nlm.nih.gov/gene/?term=1241 "BLT1, BLTR, CMKRL1, GPR161, LTBR1, P2RY7, P2Y7, LTB4R " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002820 124222 PAQR4 http://www.ncbi.nlm.nih.gov/gene/?term=124222 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002821 124323 Rps23 http://www.ncbi.nlm.nih.gov/gene/?term=124323 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00002822 124402 UBALD1 http://www.ncbi.nlm.nih.gov/gene/?term=124402 "FAM100A, PP11303 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002823 124411 ZNF720 http://www.ncbi.nlm.nih.gov/gene/?term=124411 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002824 124446 TMEM219 http://www.ncbi.nlm.nih.gov/gene/?term=124446 IGFBP-3R mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002825 124446 TMEM219 http://www.ncbi.nlm.nih.gov/gene/?term=124446 IGFBP-3R mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002826 12444 Ccnd2 http://www.ncbi.nlm.nih.gov/gene/?term=12444 "2600016F06Rik, AI256817, BF642806, C86853, Vin-1, Vin1, cD2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002827 12444 Ccnd2 http://www.ncbi.nlm.nih.gov/gene/?term=12444 "2600016F06Rik, AI256817, BF642806, C86853, Vin-1, Vin1, cD2 " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00002828 124454 EARS2 http://www.ncbi.nlm.nih.gov/gene/?term=124454 "COXPD12, MSE1, gluRS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002829 124454 EARS2 http://www.ncbi.nlm.nih.gov/gene/?term=124454 "COXPD12, MSE1, gluRS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002830 124454 EARS2 http://www.ncbi.nlm.nih.gov/gene/?term=124454 "COXPD12, MSE1, gluRS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002831 12445 Ccnd3 http://www.ncbi.nlm.nih.gov/gene/?term=12445 "9230106B05Rik, AA682053, AL024085, AW146355, C78795 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002832 12445 Ccnd3 http://www.ncbi.nlm.nih.gov/gene/?term=12445 "9230106B05Rik, AA682053, AL024085, AW146355, C78795 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002833 124460 SNX20 http://www.ncbi.nlm.nih.gov/gene/?term=124460 SLIC1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002834 124491 TMEM170A http://www.ncbi.nlm.nih.gov/gene/?term=124491 TMEM170 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002835 1244 ABCC2 http://www.ncbi.nlm.nih.gov/gene/?term=1244 "ABC30, CMOAT, DJS, MRP2, cMRP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002836 12450 Ccng1 http://www.ncbi.nlm.nih.gov/gene/?term=12450 AI314029 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002837 12450 Ccng1 http://www.ncbi.nlm.nih.gov/gene/?term=12450 AI314029 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002838 124512 METTL23 http://www.ncbi.nlm.nih.gov/gene/?term=124512 "C17orf95, MRT44 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002839 12452 Ccng2 http://www.ncbi.nlm.nih.gov/gene/?term=12452 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002840 12453 Ccni http://www.ncbi.nlm.nih.gov/gene/?term=12453 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002841 12455 Ccnt1 http://www.ncbi.nlm.nih.gov/gene/?term=12455 "2810478G24Rik, AI115585, CycT1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002842 124565 SLC38A10 http://www.ncbi.nlm.nih.gov/gene/?term=124565 PP1744 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002843 124565 SLC38A10 http://www.ncbi.nlm.nih.gov/gene/?term=124565 PP1744 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002844 12457 Noct http://www.ncbi.nlm.nih.gov/gene/?term=12457 "AU043840, Ccr4, Ccrn4l " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002845 12457 Noct http://www.ncbi.nlm.nih.gov/gene/?term=12457 "AU043840, Ccr4, Ccrn4l " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002846 124583 CANT1 http://www.ncbi.nlm.nih.gov/gene/?term=124583 "DBQD, DBQD1, SCAN-1, SCAN1, SHAPY " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002847 124583 CANT1 http://www.ncbi.nlm.nih.gov/gene/?term=124583 "DBQD, DBQD1, SCAN-1, SCAN1, SHAPY " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002848 124583 CANT1 http://www.ncbi.nlm.nih.gov/gene/?term=124583 "DBQD, DBQD1, SCAN-1, SCAN1, SHAPY " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002849 12460 Ccs http://www.ncbi.nlm.nih.gov/gene/?term=12460 Ccsd mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002850 12462 Cct3 http://www.ncbi.nlm.nih.gov/gene/?term=12462 "AL024092, Cctg, Tcp1-rs3, TriC-P5 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002851 124637 CYB5D1 http://www.ncbi.nlm.nih.gov/gene/?term=124637 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002852 124637 CYB5D1 http://www.ncbi.nlm.nih.gov/gene/?term=124637 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002853 12464 Cct4 http://www.ncbi.nlm.nih.gov/gene/?term=12464 "2610204B21Rik, A45, C78323, Cctd " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002854 12469 Cct8 http://www.ncbi.nlm.nih.gov/gene/?term=12469 "AI132397, Cctq, Tcpq " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002855 124801 LSM12 http://www.ncbi.nlm.nih.gov/gene/?term=124801 PNAS-135 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002856 124808 CCDC43 http://www.ncbi.nlm.nih.gov/gene/?term=124808 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002857 124808 CCDC43 http://www.ncbi.nlm.nih.gov/gene/?term=124808 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002858 124817 CNTD1 http://www.ncbi.nlm.nih.gov/gene/?term=124817 CNTD mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002859 12484 Cd24a http://www.ncbi.nlm.nih.gov/gene/?term=12484 "Cd24, HSA, Ly-52, nectadrin " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002860 12491 Cd36 http://www.ncbi.nlm.nih.gov/gene/?term=12491 "FAT, GPIV, Scarb3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002861 124925 SEZ6 http://www.ncbi.nlm.nih.gov/gene/?term=124925 BSRPC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002862 12492 Scarb2 http://www.ncbi.nlm.nih.gov/gene/?term=12492 "9330185J12Rik, Cd36l2, LGP85, LIMP II, LIMP-2, MLGP85 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002863 124935 SLC43A2 http://www.ncbi.nlm.nih.gov/gene/?term=124935 LAT4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002864 124936 CYB5D2 http://www.ncbi.nlm.nih.gov/gene/?term=124936 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002865 124975 GGT6 http://www.ncbi.nlm.nih.gov/gene/?term=124975 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002866 124976 SPNS2 http://www.ncbi.nlm.nih.gov/gene/?term=124976 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002867 124976 SPNS2 http://www.ncbi.nlm.nih.gov/gene/?term=124976 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002868 124995 MRPL10 http://www.ncbi.nlm.nih.gov/gene/?term=124995 "L10MT, MRP-L10, MRP-L8, MRPL8, RPML8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002869 124997 WDR81 http://www.ncbi.nlm.nih.gov/gene/?term=124997 "CAMRQ2, PPP1R166 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002870 125050 RN7SK http://www.ncbi.nlm.nih.gov/gene/?term=125050 7SK lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002871 125050 RN7SK http://www.ncbi.nlm.nih.gov/gene/?term=125050 7SK lncRNA Homo sapiens 25332394 Nucleus - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/7SK/ RLID00002872 125050 RN7SK http://www.ncbi.nlm.nih.gov/gene/?term=125050 7SK lncRNA Homo sapiens 22855529 Nucleus Hela cell In situ hybridization "Nuclear speckle-associated RNAs include uridine-rich small nuclear RNAs (UsnRNAs), 7SK RNA, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) long ncRNA (lncRNA), and a population of uncharacterized poly(A)+ RNAs (Spector and Lamond, 2011 blue right-pointing triangle). " RLID00002873 125050 RN7SK http://www.ncbi.nlm.nih.gov/gene/?term=125050 7SK snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00002874 125050 RN7SK http://www.ncbi.nlm.nih.gov/gene/?term=125050 7SK snRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00002875 125058 TBC1D16 http://www.ncbi.nlm.nih.gov/gene/?term=125058 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002876 125061 AFMID http://www.ncbi.nlm.nih.gov/gene/?term=125061 "FKF, KF, KFA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002877 125061 AFMID http://www.ncbi.nlm.nih.gov/gene/?term=125061 "FKF, KF, KFA " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002878 12509 Cd59a http://www.ncbi.nlm.nih.gov/gene/?term=12509 "AA987121, Cd59, protectin " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002879 125144 LRRC75A-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=125144 "C17orf45, C17orf76-AS1, FAM211A-AS1, NCRNA00188, TSAP19 " lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002880 125144 LRRC75A-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=125144 "C17orf45, C17orf76-AS1, FAM211A-AS1, NCRNA00188, TSAP19 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002881 125144 LRRC75A-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=125144 "C17orf45, C17orf76-AS1, FAM211A-AS1, NCRNA00188, TSAP19 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002882 125144 LRRC75A-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=125144 "C17orf45, C17orf76-AS1, FAM211A-AS1, NCRNA00188, TSAP19 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002883 125170 MIEF2 http://www.ncbi.nlm.nih.gov/gene/?term=125170 "MID49, SMCR7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002884 12519 Cd80 http://www.ncbi.nlm.nih.gov/gene/?term=12519 "B71, Cd28l, Ly-53, Ly53, MIC17, TSA1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002885 125228 FAM210A http://www.ncbi.nlm.nih.gov/gene/?term=125228 "C18orf19, HsT2329 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002886 125228 FAM210A http://www.ncbi.nlm.nih.gov/gene/?term=125228 "C18orf19, HsT2329 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002887 125228 FAM210A http://www.ncbi.nlm.nih.gov/gene/?term=125228 "C18orf19, HsT2329 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002888 12527 Cd9 http://www.ncbi.nlm.nih.gov/gene/?term=12527 Tspan29 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002889 12537 Cdk11b http://www.ncbi.nlm.nih.gov/gene/?term=12537 "AA989746, CDK11-p110, CDK11-p46, CDK11-p58, Cdc11b, Cdc2l1, Cdc2l2, Cdk11, p58 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002890 12545 Cdc7 http://www.ncbi.nlm.nih.gov/gene/?term=12545 "AI597260l1, muCdc7, Cdc7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002891 12554 Cdh13 http://www.ncbi.nlm.nih.gov/gene/?term=12554 "4932416G01Rik, Cdht, Tcad " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002892 12558 Cdh2 http://www.ncbi.nlm.nih.gov/gene/?term=12558 "CDHN, N-CAD, Ncad " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002893 12569 Cdk5r1 http://www.ncbi.nlm.nih.gov/gene/?term=12569 "Cdk5r, D11Bwg0379e, p25, p35 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002894 12572 Cdk7 http://www.ncbi.nlm.nih.gov/gene/?term=12572 "AI323415, AI528512, C230069N13, Cdkn7, Crk4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002895 12578 Cdkn2a http://www.ncbi.nlm.nih.gov/gene/?term=12578 "ARF-INK4a, Arf, INK4a-ARF, Ink4a/Arf, MTS1, Pctr1, p16, p16(INK4a), p16INK4a, p19, p19ARF " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002896 12589 Ift81 http://www.ncbi.nlm.nih.gov/gene/?term=12589 "AW060663, Cdv-1, Cdv-1r, Cdv1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002897 125919 ZNF543 http://www.ncbi.nlm.nih.gov/gene/?term=125919 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002898 125919 ZNF543 http://www.ncbi.nlm.nih.gov/gene/?term=125919 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002899 125950 RAVER1 http://www.ncbi.nlm.nih.gov/gene/?term=125950 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002900 125950 RAVER1 http://www.ncbi.nlm.nih.gov/gene/?term=125950 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002901 125962 OR7G1 http://www.ncbi.nlm.nih.gov/gene/?term=125962 "OR19-15, OR19-8P, OR7G1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002902 125962 OR7G1 http://www.ncbi.nlm.nih.gov/gene/?term=125962 "OR19-15, OR19-8P, OR7G1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002903 125965 COX6B2 http://www.ncbi.nlm.nih.gov/gene/?term=125965 "COXVIB2, CT59 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002904 125965 COX6B2 http://www.ncbi.nlm.nih.gov/gene/?term=125965 "COXVIB2, CT59 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002905 125988 C19orf70 http://www.ncbi.nlm.nih.gov/gene/?term=125988 "MIC13, P117, QIL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002906 125988 C19orf70 http://www.ncbi.nlm.nih.gov/gene/?term=125988 "MIC13, P117, QIL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002907 1259 CNGA1 http://www.ncbi.nlm.nih.gov/gene/?term=1259 "CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002908 125 ADH1B http://www.ncbi.nlm.nih.gov/gene/?term=125 "ADH2, HEL-S-117 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002909 126070 ZNF440 http://www.ncbi.nlm.nih.gov/gene/?term=126070 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002910 126070 ZNF440 http://www.ncbi.nlm.nih.gov/gene/?term=126070 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002911 126070 ZNF440 http://www.ncbi.nlm.nih.gov/gene/?term=126070 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002912 12608 Cebpb http://www.ncbi.nlm.nih.gov/gene/?term=12608 "C/EBPbeta, CRP2, IL-6DBP, LAP, LIP, NF-IL6, NF-M, Nfil6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002913 12608 Cebpb http://www.ncbi.nlm.nih.gov/gene/?term=12608 "C/EBPbeta, CRP2, IL-6DBP, LAP, LIP, NF-IL6, NF-M, Nfil6 " mRNA Mus musculus 18678862 Nucleus betawt|betad/s cell RT-PCR "To investigate the influence of HuR on nuclear processing of the C/EBPb mRNA, we examined nuclear polyadenylation of the C/EBPb transcripts from the betawt and betad/s cell lines. To accumulate the data presented in Fig. 7, RNA was isolated from the nuclear fraction and subjected to reverse transcription using an oligo(dT) primer/adapter followed by PCR using a forward primer located 298 nucleotides upstream of the site of poly(A) addition of the C/EBPb mRNA in conjunction with the n32P-labeled oligo(dT) primer/adapter. The data suggest that in the absence of HuR binding, the C/EBPb mRNA is more extensively polyadenylated, leading to translocation to the cytosol. However, in betawt, which binds HuR, polyadenylation appears to occur to a lesser extent, with approximately one-third of the RNA (relative to betad/s) reaching the cytosol. " RLID00002914 12608 Cebpb http://www.ncbi.nlm.nih.gov/gene/?term=12608 "C/EBPbeta, CRP2, IL-6DBP, LAP, LIP, NF-IL6, NF-M, Nfil6 " mRNA Mus musculus 18678862 Cytosol MEF-3T3 cell RT-PCR "The real-time PCR data shown in Fig. 5B indicate that at all time points betad/s mRNA accumulated in the cytosol to a greater degree than the betawt message. Thus, the loss of the ability to bind HuR at the canonical ARE (present in βwt, but absent in betad/s) did not hinder the movement of the C/EBPb mRNA into the cytosol. " RLID00002915 126119 JOSD2 http://www.ncbi.nlm.nih.gov/gene/?term=126119 SBBI54 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002916 12611 Cebpg http://www.ncbi.nlm.nih.gov/gene/?term=12611 "C/EBP[g], C/EBPgamma, GPE1-BP, Gpe1bp, Ig/EBP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002917 126133 ALDH16A1 http://www.ncbi.nlm.nih.gov/gene/?term=126133 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002918 12616 Cenpb http://www.ncbi.nlm.nih.gov/gene/?term=12616 CENP-B mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002919 12616 Cenpb http://www.ncbi.nlm.nih.gov/gene/?term=12616 CENP-B mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00002920 126208 ZNF787 http://www.ncbi.nlm.nih.gov/gene/?term=126208 TIP20 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002921 126231 ZNF573 http://www.ncbi.nlm.nih.gov/gene/?term=126231 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002922 126231 ZNF573 http://www.ncbi.nlm.nih.gov/gene/?term=126231 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002923 126282 TNFAIP8L1 http://www.ncbi.nlm.nih.gov/gene/?term=126282 TIPE1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002924 126298 IRGQ http://www.ncbi.nlm.nih.gov/gene/?term=126298 "FKSG271, IRGQ " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002925 126298 IRGQ http://www.ncbi.nlm.nih.gov/gene/?term=126298 "FKSG271, IRGQ " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002926 126299 ZNF428 http://www.ncbi.nlm.nih.gov/gene/?term=126299 "C19orf37, Zfp428 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002927 126308 MOB3A http://www.ncbi.nlm.nih.gov/gene/?term=126308 "MOB1C, MOBKL2A, moblak " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002928 126308 MOB3A http://www.ncbi.nlm.nih.gov/gene/?term=126308 "MOB1C, MOBKL2A, moblak " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002929 126321 MFSD12 http://www.ncbi.nlm.nih.gov/gene/?term=126321 "C19orf28, PP3501 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002930 126321 MFSD12 http://www.ncbi.nlm.nih.gov/gene/?term=126321 "C19orf28, PP3501 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002931 126328 NDUFA11 http://www.ncbi.nlm.nih.gov/gene/?term=126328 "B14.7, CI-B14.7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002932 126328 NDUFA11 http://www.ncbi.nlm.nih.gov/gene/?term=126328 "B14.7, CI-B14.7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002933 126364 LRRC25 http://www.ncbi.nlm.nih.gov/gene/?term=126364 MAPA mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002934 126364 LRRC25 http://www.ncbi.nlm.nih.gov/gene/?term=126364 MAPA mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002935 126382 NR2C2AP http://www.ncbi.nlm.nih.gov/gene/?term=126382 TRA16 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002936 1263 PLK3 http://www.ncbi.nlm.nih.gov/gene/?term=1263 "CNK, FNK, PLK-3, PRK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002937 126432 RINL http://www.ncbi.nlm.nih.gov/gene/?term=126432 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002938 126432 RINL http://www.ncbi.nlm.nih.gov/gene/?term=126432 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002939 12648 Chd1 http://www.ncbi.nlm.nih.gov/gene/?term=12648 "4930525N21Rik, AI851787, AW555109 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002940 1264 CNN1 http://www.ncbi.nlm.nih.gov/gene/?term=1264 "HEL-S-14, SMCC, Sm-Calp " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002941 12651 Chkb http://www.ncbi.nlm.nih.gov/gene/?term=12651 "Chetk, Chkl, Ck, Ck/Ek, Ck/Ek-beta, Ckb, Ckekb, Ek " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002942 126526 C19orf47 http://www.ncbi.nlm.nih.gov/gene/?term=126526 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002943 12653 Chgb http://www.ncbi.nlm.nih.gov/gene/?term=12653 Scg-1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002944 12659 Ovgp1 http://www.ncbi.nlm.nih.gov/gene/?term=12659 "120kDa, AU016433, AU019448, Chit5, MOGP, OGP, muc9 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002945 12659 Ovgp1 http://www.ncbi.nlm.nih.gov/gene/?term=12659 "120kDa, AU016433, AU019448, Chit5, MOGP, OGP, muc9 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002946 1265 CNN2 http://www.ncbi.nlm.nih.gov/gene/?term=1265 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002947 1265 CNN2 http://www.ncbi.nlm.nih.gov/gene/?term=1265 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002948 1265 CNN2 http://www.ncbi.nlm.nih.gov/gene/?term=1265 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002949 1265 CNN2 http://www.ncbi.nlm.nih.gov/gene/?term=1265 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002950 12660 Chka http://www.ncbi.nlm.nih.gov/gene/?term=12660 "CK, CK/EK-alpha, Chetk-alpha, Chk, ChoK, EK, EtnK-alpha " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002951 12662 Chm http://www.ncbi.nlm.nih.gov/gene/?term=12662 Rep-1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002952 126661 CCDC163P http://www.ncbi.nlm.nih.gov/gene/?term=126661 C1orf231 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002953 1266 CNN3 http://www.ncbi.nlm.nih.gov/gene/?term=1266 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002954 126731 CCSAP http://www.ncbi.nlm.nih.gov/gene/?term=126731 "C1orf96, CSAP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002955 12675 Chuk http://www.ncbi.nlm.nih.gov/gene/?term=12675 "AI2566581, Fbx24, Fbxo24, IKBKA, IKK1, Ikka, NFKBIKA, Chuk " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002956 126789 PUSL1 http://www.ncbi.nlm.nih.gov/gene/?term=126789 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002957 126792 B3GALT6 http://www.ncbi.nlm.nih.gov/gene/?term=126792 "EDSP2, SEMDJL1, beta3GalT6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002958 126792 B3GALT6 http://www.ncbi.nlm.nih.gov/gene/?term=126792 "EDSP2, SEMDJL1, beta3GalT6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002959 1267 CNP http://www.ncbi.nlm.nih.gov/gene/?term=1267 CNP1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002960 1267 CNP http://www.ncbi.nlm.nih.gov/gene/?term=1267 CNP1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00002961 1267 CNP http://www.ncbi.nlm.nih.gov/gene/?term=1267 CNP1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002962 1267 CNP http://www.ncbi.nlm.nih.gov/gene/?term=1267 CNP1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002963 1267 CNP http://www.ncbi.nlm.nih.gov/gene/?term=1267 CNP1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002964 1268 CNR1 http://www.ncbi.nlm.nih.gov/gene/?term=1268 "CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002965 12695 Inadl http://www.ncbi.nlm.nih.gov/gene/?term=12695 "Cipp, Patj " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002966 126961 HIST2H3C http://www.ncbi.nlm.nih.gov/gene/?term=126961 "H3, H3.2, H3/M, H3F2, H3FM, H3FN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002967 126961 HIST2H3C http://www.ncbi.nlm.nih.gov/gene/?term=126961 "H3, H3.2, H3/M, H3F2, H3FM, H3FN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00002968 127018 LYPLAL1 http://www.ncbi.nlm.nih.gov/gene/?term=127018 Q96AV0 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002969 12704 Cit http://www.ncbi.nlm.nih.gov/gene/?term=12704 "C030025P15Rik, CRIK, CRIK-SK-k, Cit " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002970 12704 Cit http://www.ncbi.nlm.nih.gov/gene/?term=12704 "C030025P15Rik, CRIK, CRIK-SK-k, Cit " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002971 1270 CNTF http://www.ncbi.nlm.nih.gov/gene/?term=1270 HCNTF mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002972 12715 Ckm http://www.ncbi.nlm.nih.gov/gene/?term=12715 "Ckmm, M-CK, MCK " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002973 12721 Coro1a http://www.ncbi.nlm.nih.gov/gene/?term=12721 "Clabp, Lmb3, TACO, p57 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002974 12722 Clca3a1 http://www.ncbi.nlm.nih.gov/gene/?term=12722 "Cacc, Clca1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002975 12724 Clcn2 http://www.ncbi.nlm.nih.gov/gene/?term=12724 "AL118368, ClC-2, Clc2, nmf240 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002976 12725 Clcn3 http://www.ncbi.nlm.nih.gov/gene/?term=12725 Clc3 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002977 127262 TPRG1L http://www.ncbi.nlm.nih.gov/gene/?term=127262 "FAM79A, h-mover, mover " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002978 127262 TPRG1L http://www.ncbi.nlm.nih.gov/gene/?term=127262 "FAM79A, h-mover, mover " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002979 12727 Clcn4 http://www.ncbi.nlm.nih.gov/gene/?term=12727 "Clc4-2-2, Clcn4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002980 127281 FAM213B http://www.ncbi.nlm.nih.gov/gene/?term=127281 C1orf93 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002981 12728 Clcn5 http://www.ncbi.nlm.nih.gov/gene/?term=12728 "5430408K11Rik, ClC-5, Clc5, D930009B12Rik, DXImx42e, Sfc13, T25545 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002982 127435 PODN http://www.ncbi.nlm.nih.gov/gene/?term=127435 "PCAN, SLRR5A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002983 12747 Clk1 http://www.ncbi.nlm.nih.gov/gene/?term=12747 STY mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002984 127495 LRRC39 http://www.ncbi.nlm.nih.gov/gene/?term=127495 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002985 12750 Clk4 http://www.ncbi.nlm.nih.gov/gene/?term=12750 "AI987988, C85119 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002986 12751 Tpp1 http://www.ncbi.nlm.nih.gov/gene/?term=12751 "Cln2, LPIC, TPP-1, TPP-I " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002987 12752 Cln3 http://www.ncbi.nlm.nih.gov/gene/?term=12752 AI323623 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002988 12753 Clock http://www.ncbi.nlm.nih.gov/gene/?term=12753 "5330400M04Rik, KAT13D " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002989 127544 RNF19B http://www.ncbi.nlm.nih.gov/gene/?term=127544 "IBRDC3, NKLAM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002990 127602 DNAH14 http://www.ncbi.nlm.nih.gov/gene/?term=127602 "C1orf67, Dnahc14, HL-18, HL18 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002991 12764 Cmas http://www.ncbi.nlm.nih.gov/gene/?term=12764 "AW208911, CMPNeu5Ac, D6Bwg0250e " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00002992 127687 C1orf122 http://www.ncbi.nlm.nih.gov/gene/?term=127687 ALAESM mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002993 12769 Ccr9 http://www.ncbi.nlm.nih.gov/gene/?term=12769 "A130091K22Rik, Cmkbr10, GPR-9-6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002994 127703 C1orf216 http://www.ncbi.nlm.nih.gov/gene/?term=127703 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002995 127707 KLHDC7A http://www.ncbi.nlm.nih.gov/gene/?term=127707 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002996 127733 UBXN10 http://www.ncbi.nlm.nih.gov/gene/?term=127733 UBXD3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00002997 12776 Ccr8 http://www.ncbi.nlm.nih.gov/gene/?term=12776 "C-C, C-C CKR-8, CC-CKR-8, CCR-8, CKR-8, Cmkbr8, mCCR8 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00002998 127829 ARL8A http://www.ncbi.nlm.nih.gov/gene/?term=127829 "ARL10B, GIE2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00002999 127829 ARL8A http://www.ncbi.nlm.nih.gov/gene/?term=127829 "ARL10B, GIE2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003000 127829 ARL8A http://www.ncbi.nlm.nih.gov/gene/?term=127829 "ARL10B, GIE2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003001 127845 GOLT1A http://www.ncbi.nlm.nih.gov/gene/?term=127845 "CGI-141, GOT1, HMFN1187, YMR292W " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003002 12785 Cnbp http://www.ncbi.nlm.nih.gov/gene/?term=12785 "AA4087101, Znf9, Cnbp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003003 1278 COL1A2 http://www.ncbi.nlm.nih.gov/gene/?term=1278 OI4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003004 12793 Cnih1 http://www.ncbi.nlm.nih.gov/gene/?term=12793 "0610007J15, CNIH-1, Cnih " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003005 127943 FCRLB http://www.ncbi.nlm.nih.gov/gene/?term=127943 "FCRL2, FCRLM2, FCRLY, FREB-2, FcRY " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003006 12795 Plk3 http://www.ncbi.nlm.nih.gov/gene/?term=12795 "Cnk, Fnk, PLK-3, PRK " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003007 12797935 CR32027 http://www.ncbi.nlm.nih.gov/gene/?term=12797935 "Dmel_ BcDNA:RE02231, CG32027, Dmel\CR32027, Dmel_CG32027 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00003008 12799 Cnp http://www.ncbi.nlm.nih.gov/gene/?term=12799 "CNPase-1, Cnp1, Cnp " mRNA Mus musculus 7877439 Cytoplasm Brain In situ hybridization A similar staining pattern was evident in sections hybridized with CNP riboprobe (Fig. 4C) suggesting that the distribution of both CNP and PLP mRNA was primarily perinuclear. RLID00003009 12801 Cnr1 http://www.ncbi.nlm.nih.gov/gene/?term=12801 "CB-R, CB1, CB1R " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003010 12805 Cntn1 http://www.ncbi.nlm.nih.gov/gene/?term=12805 "AW495098, CNTN, F3cam, usl " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003011 128061 C1orf131 http://www.ncbi.nlm.nih.gov/gene/?term=128061 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003012 12807 Hps3 http://www.ncbi.nlm.nih.gov/gene/?term=12807 coa mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003013 128153 SPATA17 http://www.ncbi.nlm.nih.gov/gene/?term=128153 "IQCH, MSRG-11, MSRG11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003014 12815 Col11a2 http://www.ncbi.nlm.nih.gov/gene/?term=12815 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003015 128178 EDARADD http://www.ncbi.nlm.nih.gov/gene/?term=128178 "ECTD11A, ECTD11B, ED3, EDA3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003016 128178 EDARADD http://www.ncbi.nlm.nih.gov/gene/?term=128178 "ECTD11A, ECTD11B, ED3, EDA3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003017 1281 COL3A1 http://www.ncbi.nlm.nih.gov/gene/?term=1281 EDS4A mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003018 128218 TMEM125 http://www.ncbi.nlm.nih.gov/gene/?term=128218 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003019 128239 IQGAP3 http://www.ncbi.nlm.nih.gov/gene/?term=128239 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003020 128240 NAXE http://www.ncbi.nlm.nih.gov/gene/?term=128240 "AIBP, APOA1BP, YJEFN1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003021 128240 NAXE http://www.ncbi.nlm.nih.gov/gene/?term=128240 "AIBP, APOA1BP, YJEFN1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003022 128240 NAXE http://www.ncbi.nlm.nih.gov/gene/?term=128240 "AIBP, YJEFN1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003023 1282 COL4A1 http://www.ncbi.nlm.nih.gov/gene/?term=1282 "BSVD, RATOR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003024 1282 COL4A1 http://www.ncbi.nlm.nih.gov/gene/?term=1282 "BSVD, RATOR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003025 128308 MRPL55 http://www.ncbi.nlm.nih.gov/gene/?term=128308 "AAVG5835, L55nt, MRP-L55, PRO19675 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003026 128308 MRPL55 http://www.ncbi.nlm.nih.gov/gene/?term=128308 "AAVG5835, L55nt, MRP-L55, PRO19675 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003027 128312 HIST3H2BB http://www.ncbi.nlm.nih.gov/gene/?term=128312 H2Bb mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003028 12831 Col5a1 http://www.ncbi.nlm.nih.gov/gene/?term=12831 AI413331 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003029 12832 Col5a2 http://www.ncbi.nlm.nih.gov/gene/?term=12832 1110014L14Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003030 128338 DRAM2 http://www.ncbi.nlm.nih.gov/gene/?term=128338 "CORD21, PRO180, TMEM77, WWFQ154 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003031 128338 DRAM2 http://www.ncbi.nlm.nih.gov/gene/?term=128338 "CORD21, PRO180, TMEM77, WWFQ154 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003032 128387 TATDN3 http://www.ncbi.nlm.nih.gov/gene/?term=128387 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003033 128387 TATDN3 http://www.ncbi.nlm.nih.gov/gene/?term=128387 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003034 128387 TATDN3 http://www.ncbi.nlm.nih.gov/gene/?term=128387 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003035 128387 TATDN3 http://www.ncbi.nlm.nih.gov/gene/?term=128387 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003036 128439 SNHG11 http://www.ncbi.nlm.nih.gov/gene/?term=128439 "C20orf198, LINC00101, NCRNA00101 " lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003037 12847 Copa http://www.ncbi.nlm.nih.gov/gene/?term=12847 "AU040324, xenin " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003038 128486 FITM2 http://www.ncbi.nlm.nih.gov/gene/?term=128486 "C20orf142, Fit2, dJ881L22.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003039 12848 Cops2 http://www.ncbi.nlm.nih.gov/gene/?term=12848 "AI315723, C85265, Csn2, Sgn2, TRIP-15, Trip15 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003040 1284 COL4A2 http://www.ncbi.nlm.nih.gov/gene/?term=1284 "ICH, POREN2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003041 12856 Cox17 http://www.ncbi.nlm.nih.gov/gene/?term=12856 AI037035 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00003042 12859 Cox5b http://www.ncbi.nlm.nih.gov/gene/?term=12859 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003043 128637 TBC1D20 http://www.ncbi.nlm.nih.gov/gene/?term=128637 "C20orf140, WARBM4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003044 128637 TBC1D20 http://www.ncbi.nlm.nih.gov/gene/?term=128637 "C20orf140, WARBM4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003045 128637 TBC1D20 http://www.ncbi.nlm.nih.gov/gene/?term=128637 "C20orf140, WARBM4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003046 12865 Cox7a1 http://www.ncbi.nlm.nih.gov/gene/?term=12865 "COX7A, COX7AH, COX7AM " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003047 12866 Cox7a2 http://www.ncbi.nlm.nih.gov/gene/?term=12866 "COX7AL, Cox7a3, CoxVIIa-L " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003048 12873 Cpa3 http://www.ncbi.nlm.nih.gov/gene/?term=12873 MC-CPA mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003049 12874 Cpd http://www.ncbi.nlm.nih.gov/gene/?term=12874 "AA960140, AW322530, D830034L15Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003050 12876 Cpe http://www.ncbi.nlm.nih.gov/gene/?term=12876 "CPH, Cph-1, Cph1, R74677, fat " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003051 12876 Cpe http://www.ncbi.nlm.nih.gov/gene/?term=12876 "CPH, Cph-1, Cph1, R74677, fat " mRNA Mus musculus 15972000 Endoplasmic reticulum MIN6 cell Northern blot "Figure 2: Glucose stimulates the recruitment of mRNAs encoding secretory membrane proteins to the ER: subcellular fractionation using the digitonin method. MIN6 cells were preincubated in KRB containing 2 mM glucose for 1 h followed by incubation in KRB containing 2 or 20 mM glucose for a further period of 1 h. (a) Cells were permeabilized with digitonin and pelleted resulting in a membrane fraction (Mem) and a cytosolic fraction (Cyt). The 10% refers to 10% of total RNA/protein. RNA was isolated from each fraction and run on a 1% agarose formaldehyde gel, transferred on to a nylon membrane and probed for proinsulin (PI), PC2, CPH and actin mRNAs. The intensities of the bands were quantified using ImageJ and the mRNA levels were expressed as a percentage of total mRNA. (b) Protein samples from each fraction were run on SDS/PAGE (20% of membrane fraction and 20% of cytosolic fraction) and subjected to immunoblotting with anti-ERK2, calreticulin and SRP54 antibodies. Detection was by enhanced chemiluminescence. The results presented are representative of three separate experiments. Data are collected from Figure 2. " RLID00003052 1287 COL4A5 http://www.ncbi.nlm.nih.gov/gene/?term=1287 "ASLN, ATS, CA54 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003053 1287 COL4A5 http://www.ncbi.nlm.nih.gov/gene/?term=1287 "ASLN, ATS, CA54 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003054 128866 CHMP4B http://www.ncbi.nlm.nih.gov/gene/?term=128866 "C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003055 128866 CHMP4B http://www.ncbi.nlm.nih.gov/gene/?term=128866 "C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003056 128866 CHMP4B http://www.ncbi.nlm.nih.gov/gene/?term=128866 "C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003057 128869 PIGU http://www.ncbi.nlm.nih.gov/gene/?term=128869 "CDC91L1, GAB1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003058 12896 Cpt2 http://www.ncbi.nlm.nih.gov/gene/?term=12896 "AI323697, CPTII " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003059 128977 C22orf39 http://www.ncbi.nlm.nih.gov/gene/?term=128977 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003060 128977 C22orf39 http://www.ncbi.nlm.nih.gov/gene/?term=128977 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003061 128989 TANGO2 http://www.ncbi.nlm.nih.gov/gene/?term=128989 "C22orf25, MECRCN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003062 128989 TANGO2 http://www.ncbi.nlm.nih.gov/gene/?term=128989 "C22orf25, MECRCN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003063 128 ADH5 http://www.ncbi.nlm.nih.gov/gene/?term=128 "ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR, HEL-S-60p " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003064 128 ADH5 http://www.ncbi.nlm.nih.gov/gene/?term=128 "ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR, HEL-S-60p " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003065 128 ADH5 http://www.ncbi.nlm.nih.gov/gene/?term=128 "ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR, HEL-S-60p " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003066 12903 Crabp1 http://www.ncbi.nlm.nih.gov/gene/?term=12903 "AI326249, CRABP-I, Crabp-1, CrabpI, Rbp-5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003067 12904 Crabp2 http://www.ncbi.nlm.nih.gov/gene/?term=12904 "AI893628, Crabp-2, CrabpII " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003068 12912 Creb1 http://www.ncbi.nlm.nih.gov/gene/?term=12912 "2310001E10Rik, 3526402H21Rik, AV083133, Creb, Creb-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003069 129138 ANKRD54 http://www.ncbi.nlm.nih.gov/gene/?term=129138 LIAR mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003070 129285 PPP1R21 http://www.ncbi.nlm.nih.gov/gene/?term=129285 "CCDC128, KLRAQ1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003071 1292 COL6A2 http://www.ncbi.nlm.nih.gov/gene/?term=1292 "BTHLM1, PP3610, UCMD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003072 129303 TMEM150A http://www.ncbi.nlm.nih.gov/gene/?term=129303 "TM6P1, TMEM150 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003073 1293 COL6A3 http://www.ncbi.nlm.nih.gov/gene/?term=1293 "BTHLM1, DYT27, UCMD1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003074 12941 Pcdha5 http://www.ncbi.nlm.nih.gov/gene/?term=12941 "Cnr6, Crnr6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003075 1294 COL7A1 http://www.ncbi.nlm.nih.gov/gene/?term=1294 "EBD1, EBDCT, EBR1, NDNC8 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003076 12950 Hapln1 http://www.ncbi.nlm.nih.gov/gene/?term=12950 "BB099155, CLP, Crtl1, Crtl1l, LP, LP-1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003077 12950 Hapln1 http://www.ncbi.nlm.nih.gov/gene/?term=12950 "BB099155, CLP, Crtl1, Crtl1l, LP, LP-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003078 12955 Cryab http://www.ncbi.nlm.nih.gov/gene/?term=12955 "Crya-2, Crya2, HspB5, P23 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003079 1295 COL8A1 http://www.ncbi.nlm.nih.gov/gene/?term=1295 C3orf7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003080 129607 CMPK2 http://www.ncbi.nlm.nih.gov/gene/?term=129607 "NDK, TMPK2, TYKi, UMP-CMPK2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003081 129607 CMPK2 http://www.ncbi.nlm.nih.gov/gene/?term=129607 "NDK, TMPK2, TYKi, UMP-CMPK2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003082 129642 MBOAT2 http://www.ncbi.nlm.nih.gov/gene/?term=129642 "LPCAT4, OACT2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003083 129685 TAF8 http://www.ncbi.nlm.nih.gov/gene/?term=129685 "II, TAF, TAFII-43, TAFII43, TBN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003084 129685 TAF8 http://www.ncbi.nlm.nih.gov/gene/?term=129685 "II, TAF, TAFII-43, TAFII43, TBN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003085 12974 Cs http://www.ncbi.nlm.nih.gov/gene/?term=12974 "2610511A05Rik, 9030605P22Rik, Ahl4, BB234005, Cis " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003086 129787 TMEM18 http://www.ncbi.nlm.nih.gov/gene/?term=129787 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003087 129831 RBM45 http://www.ncbi.nlm.nih.gov/gene/?term=129831 "DRB1, RB-1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003088 129831 RBM45 http://www.ncbi.nlm.nih.gov/gene/?term=129831 "DRB1, RB-1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003089 12983 Csf2rb http://www.ncbi.nlm.nih.gov/gene/?term=12983 "AI848964, AIC2B, Bc, CDw1311, Csfgmrb, Il3r, Il3rb, Il3rb1, Il5rb, Csf2rb " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003090 129880 BBS5 http://www.ncbi.nlm.nih.gov/gene/?term=129880 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003091 129880 BBS5 http://www.ncbi.nlm.nih.gov/gene/?term=129880 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003092 1298 COL9A2 http://www.ncbi.nlm.nih.gov/gene/?term=1298 "DJ39G22.4, EDM2, MED, STL5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003093 1299 COL9A3 http://www.ncbi.nlm.nih.gov/gene/?term=1299 "DJ885L7.4.1, EDM3, IDD, MED " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003094 13002 Dnajc5 http://www.ncbi.nlm.nih.gov/gene/?term=13002 "2610314I24Rik, AU018536, Csp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003095 13003 Vcan http://www.ncbi.nlm.nih.gov/gene/?term=13003 "5430420N07Rik, 9430051N09, Cspg2, DPEAAE, NG2, PG-M, PG-M(V0), PG-M(V1), hdf " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003096 13004 Ncan http://www.ncbi.nlm.nih.gov/gene/?term=13004 "C230035B04, Cspg3, Cspg3-rs, Tgfbit " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003097 130074 FAM168B http://www.ncbi.nlm.nih.gov/gene/?term=130074 MANI mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003098 130074 FAM168B http://www.ncbi.nlm.nih.gov/gene/?term=130074 MANI mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003099 13007 Csrp1 http://www.ncbi.nlm.nih.gov/gene/?term=13007 "AA408841, AA959891, AW545626, CRP1, Csrp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003100 13014 Cstb http://www.ncbi.nlm.nih.gov/gene/?term=13014 "AA960480, Stfb " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003101 13018 Ctcf http://www.ncbi.nlm.nih.gov/gene/?term=13018 AW108038 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003102 13024 Ctla2a http://www.ncbi.nlm.nih.gov/gene/?term=13024 Ctla-2a mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003103 130271 PLEKHH2 http://www.ncbi.nlm.nih.gov/gene/?term=130271 PLEKHH1L mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003104 130271 PLEKHH2 http://www.ncbi.nlm.nih.gov/gene/?term=130271 PLEKHH1L mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003105 1302 COL11A2 http://www.ncbi.nlm.nih.gov/gene/?term=1302 "DFNA13, DFNB53, FBCG2, HKE5, PARP, STL3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003106 13030 Ctsb http://www.ncbi.nlm.nih.gov/gene/?term=13030 CB mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003107 130340 AP1S3 http://www.ncbi.nlm.nih.gov/gene/?term=130340 PSORS15 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003108 13034 Ctse http://www.ncbi.nlm.nih.gov/gene/?term=13034 "A430072O03Rik, C920004C08Rik, CE, CatE " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003109 130367 SGPP2 http://www.ncbi.nlm.nih.gov/gene/?term=130367 "SPP2, SPPase2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003110 13039 Ctsl http://www.ncbi.nlm.nih.gov/gene/?term=13039 "1190035F06Rik, CatL1, MEP, fs, nkt, Ctsl " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003111 1303 COL12A1 http://www.ncbi.nlm.nih.gov/gene/?term=1303 "BA209D8.1, BTHLM2L, DJ234P15.1, UCMD2, COL12A1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003112 13043 Cttn http://www.ncbi.nlm.nih.gov/gene/?term=13043 "1110020L01Rik, Ems1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003113 13047 Cux1 http://www.ncbi.nlm.nih.gov/gene/?term=13047 "CDP, Cutl1, Cux, Cux-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003114 130507 UBR3 http://www.ncbi.nlm.nih.gov/gene/?term=130507 ZNF650 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003115 13052 Cxadr http://www.ncbi.nlm.nih.gov/gene/?term=13052 "2610206D03Rik, AU016810, AW553441, CAR, MCAR, MCVADR " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003116 130540 ALS2CR12 http://www.ncbi.nlm.nih.gov/gene/?term=130540 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003117 130557 ZNF513 http://www.ncbi.nlm.nih.gov/gene/?term=130557 "HMFT0656, RP58 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003118 130574 LYPD6 http://www.ncbi.nlm.nih.gov/gene/?term=130574 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003119 130589 GALM http://www.ncbi.nlm.nih.gov/gene/?term=130589 "BLOCK25, GLAT, HEL-S-63p, IBD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003120 130589 GALM http://www.ncbi.nlm.nih.gov/gene/?term=130589 "BLOCK25, GLAT, HEL-S-63p, IBD1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003121 130589 GALM http://www.ncbi.nlm.nih.gov/gene/?term=130589 "BLOCK25, GLAT, HEL-S-63p, IBD1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003122 130617 ZFAND2B http://www.ncbi.nlm.nih.gov/gene/?term=130617 AIRAPL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003123 13063 Cycs http://www.ncbi.nlm.nih.gov/gene/?term=13063 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003124 1306 COL15A1 http://www.ncbi.nlm.nih.gov/gene/?term=1306 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003125 130813 C2orf50 http://www.ncbi.nlm.nih.gov/gene/?term=130813 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003126 130813 C2orf50 http://www.ncbi.nlm.nih.gov/gene/?term=130813 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003127 130814 PQLC3 http://www.ncbi.nlm.nih.gov/gene/?term=130814 C2orf22 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003128 130872 AHSA2 http://www.ncbi.nlm.nih.gov/gene/?term=130872 Hch1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003129 130872 AHSA2 http://www.ncbi.nlm.nih.gov/gene/?term=130872 Hch1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003130 130872 AHSA2 http://www.ncbi.nlm.nih.gov/gene/?term=130872 Hch1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003131 1308 COL17A1 http://www.ncbi.nlm.nih.gov/gene/?term=1308 "BA16H23.2, BP180, BPA-2, BPAG2, ERED, LAD-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003132 13090 Cyp2b19 http://www.ncbi.nlm.nih.gov/gene/?term=13090 CYPIIB19 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003133 130916 MTERF4 http://www.ncbi.nlm.nih.gov/gene/?term=130916 MTERFD2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003134 13097 Cyp2c38 http://www.ncbi.nlm.nih.gov/gene/?term=13097 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003135 13097 Cyp2c38 http://www.ncbi.nlm.nih.gov/gene/?term=13097 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003136 131034 CPNE4 http://www.ncbi.nlm.nih.gov/gene/?term=131034 "COPN4, CPN4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003137 131076 CCDC58 http://www.ncbi.nlm.nih.gov/gene/?term=131076 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003138 131118 DNAJC19 http://www.ncbi.nlm.nih.gov/gene/?term=131118 "PAM18, TIM14, TIMM14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003139 131118 DNAJC19 http://www.ncbi.nlm.nih.gov/gene/?term=131118 "PAM18, TIM14, TIMM14 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003140 13115 Cyp27b1 http://www.ncbi.nlm.nih.gov/gene/?term=13115 "Cp2b, Cyp1, Cyp27b, Cyp40, P450c1, Pddr, Vdd1, Vddr, VddrI, Vdr " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003141 131177 FAM3D http://www.ncbi.nlm.nih.gov/gene/?term=131177 "EF7, OIT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003142 13121 Cyp51 http://www.ncbi.nlm.nih.gov/gene/?term=13121 "AI426508, CYPLIa1, Ldm, P450-14DM, P450LI, Cyp51 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003143 1312 COMT http://www.ncbi.nlm.nih.gov/gene/?term=1312 HEL-S-98n mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003144 1312 COMT http://www.ncbi.nlm.nih.gov/gene/?term=1312 HEL-S-98n mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003145 13132 Dab2 http://www.ncbi.nlm.nih.gov/gene/?term=13132 "5730435J12Rik, AA960054, AI957090, D15Wsu122e, D630005B22Rik, Doc-2, Doc2, p96 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003146 13139 Dgka http://www.ncbi.nlm.nih.gov/gene/?term=13139 "80kDa, AW146112, Dagk1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003147 13144 Dapk3 http://www.ncbi.nlm.nih.gov/gene/?term=13144 "ZIPK, dlk " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003148 131474 CHCHD4 http://www.ncbi.nlm.nih.gov/gene/?term=131474 "MIA40, TIMM40 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003149 1314 COPA http://www.ncbi.nlm.nih.gov/gene/?term=1314 "AILJK, HEP-COP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003150 1314 COPA http://www.ncbi.nlm.nih.gov/gene/?term=1314 "AILJK, HEP-COP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003151 1314 COPA http://www.ncbi.nlm.nih.gov/gene/?term=1314 "AILJK, HEP-COP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003152 131540 ZDHHC19 http://www.ncbi.nlm.nih.gov/gene/?term=131540 DHHC19 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003153 131544 CRYBG3 http://www.ncbi.nlm.nih.gov/gene/?term=131544 "DKFZp667G2110, vlAKAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003154 131566 DCBLD2 http://www.ncbi.nlm.nih.gov/gene/?term=131566 "CLCP1, ESDN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003155 131566 DCBLD2 http://www.ncbi.nlm.nih.gov/gene/?term=131566 "CLCP1, ESDN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003156 131566 DCBLD2 http://www.ncbi.nlm.nih.gov/gene/?term=131566 "CLCP1, ESDN " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003157 1315 COPB1 http://www.ncbi.nlm.nih.gov/gene/?term=1315 COPB mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003158 1315 COPB1 http://www.ncbi.nlm.nih.gov/gene/?term=1315 COPB mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003159 1315 COPB1 http://www.ncbi.nlm.nih.gov/gene/?term=1315 COPB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003160 131601 TPRA1 http://www.ncbi.nlm.nih.gov/gene/?term=131601 "GPR175, TMEM227, TPRA40 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003161 13163 Daxx http://www.ncbi.nlm.nih.gov/gene/?term=13163 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003162 13168 Dbil5 http://www.ncbi.nlm.nih.gov/gene/?term=13168 ELP mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003163 1316 KLF6 http://www.ncbi.nlm.nih.gov/gene/?term=1316 "BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003164 1316 KLF6 http://www.ncbi.nlm.nih.gov/gene/?term=1316 "BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003165 13170 Dbp http://www.ncbi.nlm.nih.gov/gene/?term=13170 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003166 13171 Dbt http://www.ncbi.nlm.nih.gov/gene/?term=13171 D3Wsu60e mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003167 13175 Dclk1 http://www.ncbi.nlm.nih.gov/gene/?term=13175 "1700113D08Rik, 2810480F11Rik, AI836758, Click-I, Cpg16, Dcamkl1, Dcl, Dclk, mKIAA0369 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003168 1317 SLC31A1 http://www.ncbi.nlm.nih.gov/gene/?term=1317 "COPT1, CTR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003169 1317 SLC31A1 http://www.ncbi.nlm.nih.gov/gene/?term=1317 "COPT1, CTR1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003170 1317 SLC31A1 http://www.ncbi.nlm.nih.gov/gene/?term=1317 "COPT1, CTR1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003171 131870 NUDT16 http://www.ncbi.nlm.nih.gov/gene/?term=131870 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003172 131870 NUDT16 http://www.ncbi.nlm.nih.gov/gene/?term=131870 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003173 1318 SLC31A2 http://www.ncbi.nlm.nih.gov/gene/?term=1318 "COPT2, CTR2, hCTR2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003174 1318 SLC31A2 http://www.ncbi.nlm.nih.gov/gene/?term=1318 "COPT2, CTR2, hCTR2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003175 1318 SLC31A2 http://www.ncbi.nlm.nih.gov/gene/?term=1318 "COPT2, CTR2, hCTR2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003176 131965 METTL6 http://www.ncbi.nlm.nih.gov/gene/?term=131965 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003177 131965 METTL6 http://www.ncbi.nlm.nih.gov/gene/?term=131965 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003178 131965 METTL6 http://www.ncbi.nlm.nih.gov/gene/?term=131965 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003179 132001 TAMM41 http://www.ncbi.nlm.nih.gov/gene/?term=132001 "C3orf31, RAM41, TAM41 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003180 13200 Ddost http://www.ncbi.nlm.nih.gov/gene/?term=13200 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003181 132014 IL17RE http://www.ncbi.nlm.nih.gov/gene/?term=132014 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003182 13202 Ddt http://www.ncbi.nlm.nih.gov/gene/?term=13202 C78655 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003183 13207 Ddx5 http://www.ncbi.nlm.nih.gov/gene/?term=13207 "2600009A06Rik, G17P1, HUMP68, Hlr1, p68 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003184 13209 Ddx6 http://www.ncbi.nlm.nih.gov/gene/?term=13209 "1110001P04Rik, E230023J21Rik, HLR2, mRCK/P54, p54, rck " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003185 13209 Ddx6 http://www.ncbi.nlm.nih.gov/gene/?term=13209 "1110001P04Rik, E230023J21Rik, HLR2, mRCK/P54, p54, rck " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003186 13211 Dhx9 http://www.ncbi.nlm.nih.gov/gene/?term=13211 "AI326842, Ddx9, HEL-5, NDHII, RHA, mHEL-5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003187 132299 OCIAD2 http://www.ncbi.nlm.nih.gov/gene/?term=132299 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003188 132320 SCLT1 http://www.ncbi.nlm.nih.gov/gene/?term=132320 "CAP-1A, CAP1A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003189 132320 SCLT1 http://www.ncbi.nlm.nih.gov/gene/?term=132320 "CAP-1A, CAP1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003190 1325 CORT http://www.ncbi.nlm.nih.gov/gene/?term=1325 "CST-14, CST-17, CST-29 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003191 132625 ZFP42 http://www.ncbi.nlm.nih.gov/gene/?term=132625 "REX-1, REX1, ZNF754, zfp-42 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003192 132625 ZFP42 http://www.ncbi.nlm.nih.gov/gene/?term=132625 "REX-1, REX1, ZNF754, zfp-42 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003193 1326 MAP3K8 http://www.ncbi.nlm.nih.gov/gene/?term=1326 "AURA2, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003194 132789 GNPDA2 http://www.ncbi.nlm.nih.gov/gene/?term=132789 "GNP2, SB52 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003195 132789 GNPDA2 http://www.ncbi.nlm.nih.gov/gene/?term=132789 "GNP2, SB52 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003196 1327 COX4I1 http://www.ncbi.nlm.nih.gov/gene/?term=1327 "COX IV-1, COX4, COX4-1, COXIV, COXIV-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003197 132864 CPEB2 http://www.ncbi.nlm.nih.gov/gene/?term=132864 "CPE-BP2, CPEB-2, hCPEB-2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003198 1329 COX5B http://www.ncbi.nlm.nih.gov/gene/?term=1329 COXVB mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003199 1329 COX5B http://www.ncbi.nlm.nih.gov/gene/?term=1329 COXVB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003200 132 ADK http://www.ncbi.nlm.nih.gov/gene/?term=132 AK mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003201 132 ADK http://www.ncbi.nlm.nih.gov/gene/?term=132 AK mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003202 133015 PACRGL http://www.ncbi.nlm.nih.gov/gene/?term=133015 C4orf28 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003203 133015 PACRGL http://www.ncbi.nlm.nih.gov/gene/?term=133015 C4orf28 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003204 133015 PACRGL http://www.ncbi.nlm.nih.gov/gene/?term=133015 C4orf28 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003205 133015 PACRGL http://www.ncbi.nlm.nih.gov/gene/?term=133015 C4orf28 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003206 133308 SLC9B2 http://www.ncbi.nlm.nih.gov/gene/?term=133308 "NHA2, NHE10, NHEDC2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003207 133383 SETD9 http://www.ncbi.nlm.nih.gov/gene/?term=133383 C5orf35 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003208 13346 Des http://www.ncbi.nlm.nih.gov/gene/?term=13346 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003209 13353 Dgcr6 http://www.ncbi.nlm.nih.gov/gene/?term=13353 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003210 133558 MROH2B http://www.ncbi.nlm.nih.gov/gene/?term=133558 HEATR7B2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003211 133584 EGFLAM http://www.ncbi.nlm.nih.gov/gene/?term=133584 "AGRINL, AGRNL, PIKA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003212 133619 PRRC1 http://www.ncbi.nlm.nih.gov/gene/?term=133619 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003213 133619 PRRC1 http://www.ncbi.nlm.nih.gov/gene/?term=133619 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003214 13363 Dhh http://www.ncbi.nlm.nih.gov/gene/?term=13363 C78960 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003215 13367 Diaph1 http://www.ncbi.nlm.nih.gov/gene/?term=13367 "D18Wsu154e, Dia1, Diap1, Drf1, p140mDia " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003216 133686 NADK2 http://www.ncbi.nlm.nih.gov/gene/?term=133686 "C5orf33, DECRD, MNADK, NADKD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003217 133686 NADK2 http://www.ncbi.nlm.nih.gov/gene/?term=133686 "C5orf33, DECRD, MNADK, NADKD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003218 133746 JMY http://www.ncbi.nlm.nih.gov/gene/?term=133746 "WHAMM2, WHDC1L3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003219 1337 COX6A1 http://www.ncbi.nlm.nih.gov/gene/?term=1337 "CMTRID, COX6A, COX6AL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003220 1337 COX6A1 http://www.ncbi.nlm.nih.gov/gene/?term=1337 "CMTRID, COX6A, COX6AL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003221 13382 Dld http://www.ncbi.nlm.nih.gov/gene/?term=13382 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003222 13385 Dlg4 http://www.ncbi.nlm.nih.gov/gene/?term=13385 "Dlgh4, PSD-95, PSD95, SAP90, SAP90A " mRNA Mus musculus 25948262 Dendrite Hippocampus Fluorescence in situ hybridization "However, the local translation of PSD-95 mRNA within dendrites and spines, as well as the roles of FMRP or miR-125a, have not been directly studied. " RLID00003223 13386 Dlk1 http://www.ncbi.nlm.nih.gov/gene/?term=13386 "AW742678, DLK-1, DlkI, FA1, Ly107, Peg9, SCP1, ZOG, pG2, pref-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003224 13388 Dll1 http://www.ncbi.nlm.nih.gov/gene/?term=13388 Delta1 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003225 13392 Dlx2 http://www.ncbi.nlm.nih.gov/gene/?term=13392 "AW121999, Dlx-2, Tes-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003226 13392 Dlx2 http://www.ncbi.nlm.nih.gov/gene/?term=13392 "AW121999, Dlx-2, Tes-1 " mRNA Rattus norvegicus 16705037 Nucleus Embryonic brain In situ hybridization|RT-PCR "The fluorescent pattern of two bright intranuclear Evf-2 spots is consistent with that found in tissue sections vivo (see Fig. ?Fig.1f,1f, panel ii). " RLID00003227 133957 CCDC127 http://www.ncbi.nlm.nih.gov/gene/?term=133957 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003228 133957 CCDC127 http://www.ncbi.nlm.nih.gov/gene/?term=133957 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003229 133 ADM http://www.ncbi.nlm.nih.gov/gene/?term=133 "AM, PAMP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003230 133 ADM http://www.ncbi.nlm.nih.gov/gene/?term=133 "AM, PAMP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003231 13401 Dmwd http://www.ncbi.nlm.nih.gov/gene/?term=13401 "DMR-N9, Dm9 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003232 13404 Dmc1 http://www.ncbi.nlm.nih.gov/gene/?term=13404 "Dmc1h, Lim15, Mei11, sgdp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003233 1340 COX6B1 http://www.ncbi.nlm.nih.gov/gene/?term=1340 "COX6B, COXG, COXVIb1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003234 1340 COX6B1 http://www.ncbi.nlm.nih.gov/gene/?term=1340 "COX6B, COXG, COXVIb1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003235 134145 FAM173B http://www.ncbi.nlm.nih.gov/gene/?term=134145 JS-2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003236 134145 FAM173B http://www.ncbi.nlm.nih.gov/gene/?term=134145 JS-2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003237 134147 CMBL http://www.ncbi.nlm.nih.gov/gene/?term=134147 JS-1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003238 13418 Dnajc1 http://www.ncbi.nlm.nih.gov/gene/?term=13418 "4733401K02Rik, AA960110, D230036H06Rik, Dnajl1, ERdj1, ERj1p, MTJ1 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003239 13418 Dnajc1 http://www.ncbi.nlm.nih.gov/gene/?term=13418 "4733401K02Rik, AA960110, D230036H06Rik, Dnajl1, ERdj1, ERj1p, MTJ1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003240 134218 DNAJC21 http://www.ncbi.nlm.nih.gov/gene/?term=134218 "DNAJA5, GS3, JJJ1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003241 13424 Dync1h1 http://www.ncbi.nlm.nih.gov/gene/?term=13424 "9930018I23Rik, AI894280, DHC1, DHC1a, DNCL, Dnchc1, Dnec1, Dnecl, Loa, MAP1C, P22, Swl, mKIAA0325 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003242 134266 GRPEL2 http://www.ncbi.nlm.nih.gov/gene/?term=134266 Mt-GrpE#2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003243 13427 Dync1i2 http://www.ncbi.nlm.nih.gov/gene/?term=13427 "3110079H08Rik, AW554389, Dncic2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003244 134285 TMEM171 http://www.ncbi.nlm.nih.gov/gene/?term=134285 PRP2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003245 13434 Trdmt1 http://www.ncbi.nlm.nih.gov/gene/?term=13434 "Dnmt2, Rnmt2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003246 134353 LSM11 http://www.ncbi.nlm.nih.gov/gene/?term=134353 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003247 13435 Dnmt3a http://www.ncbi.nlm.nih.gov/gene/?term=13435 MmuIIIA mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003248 13437 Dnpep http://www.ncbi.nlm.nih.gov/gene/?term=13437 AA407814 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003249 134429 STARD4 http://www.ncbi.nlm.nih.gov/gene/?term=134429 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003250 134430 WDR36 http://www.ncbi.nlm.nih.gov/gene/?term=134430 "GLC1G, TA-WDRP, TAWDRP, UTP21 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003251 134430 WDR36 http://www.ncbi.nlm.nih.gov/gene/?term=134430 "GLC1G, TA-WDRP, TAWDRP, UTP21 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003252 13446 Doc2a http://www.ncbi.nlm.nih.gov/gene/?term=13446 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003253 13446 Doc2a http://www.ncbi.nlm.nih.gov/gene/?term=13446 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003254 13448 Dok1 http://www.ncbi.nlm.nih.gov/gene/?term=13448 "AW557123, p62DOK " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003255 134492 NUDCD2 http://www.ncbi.nlm.nih.gov/gene/?term=134492 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003256 134492 NUDCD2 http://www.ncbi.nlm.nih.gov/gene/?term=134492 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003257 134510 UBLCP1 http://www.ncbi.nlm.nih.gov/gene/?term=134510 CPUB1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003258 134549 SHROOM1 http://www.ncbi.nlm.nih.gov/gene/?term=134549 APXL2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003259 134549 SHROOM1 http://www.ncbi.nlm.nih.gov/gene/?term=134549 APXL2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003260 1345 COX6C http://www.ncbi.nlm.nih.gov/gene/?term=1345 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003261 1345 COX6C http://www.ncbi.nlm.nih.gov/gene/?term=1345 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003262 1347 COX7A2 http://www.ncbi.nlm.nih.gov/gene/?term=1347 "COX7AL, COX7AL1, COXVIIAL, COXVIIa-L, VIIAL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003263 1349 COX7B http://www.ncbi.nlm.nih.gov/gene/?term=1349 "APLCC, LSDMCA2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003264 1349 COX7B http://www.ncbi.nlm.nih.gov/gene/?term=1349 "APLCC, LSDMCA2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003265 13508 Dscam http://www.ncbi.nlm.nih.gov/gene/?term=13508 4932410A21Rik mRNA Mus musculus 20926679 Dendrite Hippocampus qRT-PCR "Here, we provide evidence that DSCAM mRNA is localized to dendrites and associated with CPEB1 in the adult mouse hippocampus, and describe the expression of at least five DSCAM isoforms, bearing different combinations of CPEs at their 3'-UTR. " RLID00003266 1350 COX7C http://www.ncbi.nlm.nih.gov/gene/?term=1350 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003267 1350 COX7C http://www.ncbi.nlm.nih.gov/gene/?term=1350 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003268 135112 NCOA7 http://www.ncbi.nlm.nih.gov/gene/?term=135112 "ERAP140, ESNA1-AS, Nbla00052, Nbla10993, TLDC4, dJ187J11.3, NCOA7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003269 135112 NCOA7 http://www.ncbi.nlm.nih.gov/gene/?term=135112 "ERAP140, ESNA1-AS, Nbla00052, Nbla10993, TLDC4, dJ187J11.3, NCOA7 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003270 135114 HINT3 http://www.ncbi.nlm.nih.gov/gene/?term=135114 HINT4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003271 135114 HINT3 http://www.ncbi.nlm.nih.gov/gene/?term=135114 HINT4 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003272 135114 HINT3 http://www.ncbi.nlm.nih.gov/gene/?term=135114 HINT4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003273 135138 PACRG http://www.ncbi.nlm.nih.gov/gene/?term=135138 "GLUP, HAK005771, PARK2CRG " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003274 135138 PACRG http://www.ncbi.nlm.nih.gov/gene/?term=135138 "GLUP, HAK005771, PARK2CRG " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003275 135152 B3GAT2 http://www.ncbi.nlm.nih.gov/gene/?term=135152 GLCATS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003276 13518 Dst http://www.ncbi.nlm.nih.gov/gene/?term=13518 "2310001O04Rik, A830042E19Rik, AW554249, BP230, BPAG1-n, Bpag, Bpag1, Macf2, ah, athetoid, dt, mKIAA0728, nmf203, nmf339 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003277 1351 COX8A http://www.ncbi.nlm.nih.gov/gene/?term=1351 "COX, COX8, COX8-2, COX8L, VIII, VIII-L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003278 1351 COX8A http://www.ncbi.nlm.nih.gov/gene/?term=1351 "COX, COX8, COX8-2, COX8L, VIII, VIII-L " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003279 13521 Slc26a2 http://www.ncbi.nlm.nih.gov/gene/?term=13521 "Dtd, ST-OB " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003280 135228 CD109 http://www.ncbi.nlm.nih.gov/gene/?term=135228 "CPAMD7, p180, r150 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003281 13527 Dtna http://www.ncbi.nlm.nih.gov/gene/?term=13527 "2210407P21Rik, DTN-A, Dtn, Gm19389, a-DB-1, adbn " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003282 13528 Dtnb http://www.ncbi.nlm.nih.gov/gene/?term=13528 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003283 135293 PM20D2 http://www.ncbi.nlm.nih.gov/gene/?term=135293 "ACY1L2, bA63L7.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003284 135293 PM20D2 http://www.ncbi.nlm.nih.gov/gene/?term=135293 "ACY1L2, bA63L7.3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003285 135293 PM20D2 http://www.ncbi.nlm.nih.gov/gene/?term=135293 "ACY1L2, bA63L7.3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003286 1352 COX10 http://www.ncbi.nlm.nih.gov/gene/?term=1352 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003287 1352 COX10 http://www.ncbi.nlm.nih.gov/gene/?term=1352 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003288 13537 Dusp2 http://www.ncbi.nlm.nih.gov/gene/?term=13537 PAC1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003289 1353 COX11 http://www.ncbi.nlm.nih.gov/gene/?term=1353 COX11P mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003290 1353 COX11 http://www.ncbi.nlm.nih.gov/gene/?term=1353 COX11P mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003291 13544 Dvl3 http://www.ncbi.nlm.nih.gov/gene/?term=13544 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003292 135458 HUS1B http://www.ncbi.nlm.nih.gov/gene/?term=135458 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003293 135458 HUS1B http://www.ncbi.nlm.nih.gov/gene/?term=135458 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003294 13555 E2f1 http://www.ncbi.nlm.nih.gov/gene/?term=13555 "E2F-1, mKIAA4009 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003295 1355 COX15 http://www.ncbi.nlm.nih.gov/gene/?term=1355 CEMCOX2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003296 1355 COX15 http://www.ncbi.nlm.nih.gov/gene/?term=1355 CEMCOX2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003297 1355 COX15 http://www.ncbi.nlm.nih.gov/gene/?term=1355 CEMCOX2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003298 1355 COX15 http://www.ncbi.nlm.nih.gov/gene/?term=1355 CEMCOX2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003299 1357 CPA1 http://www.ncbi.nlm.nih.gov/gene/?term=1357 CPA mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003300 135886 WBSCR28 http://www.ncbi.nlm.nih.gov/gene/?term=135886 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003301 13589 Mapre1 http://www.ncbi.nlm.nih.gov/gene/?term=13589 "5530600P05Rik, AI462499, AI504412, AW260097, BIM1p, D2Ertd459e, Eb1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003302 13592 Ebf2 http://www.ncbi.nlm.nih.gov/gene/?term=13592 "D14Ggc1e, EBF-2, Mmot1, O/E-3, OE-3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003303 135932 TMEM139 http://www.ncbi.nlm.nih.gov/gene/?term=135932 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003304 13593 Ebf3 http://www.ncbi.nlm.nih.gov/gene/?term=13593 "3110018A08Rik, O/E-2, mKIAA4201 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003305 13599 Ecel1 http://www.ncbi.nlm.nih.gov/gene/?term=13599 "DINE, xce " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003306 1359 CPA3 http://www.ncbi.nlm.nih.gov/gene/?term=1359 MC-CPA mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003307 135 ADORA2A http://www.ncbi.nlm.nih.gov/gene/?term=135 "A2aR, ADORA2, RDC8 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003308 136051 ZNF786 http://www.ncbi.nlm.nih.gov/gene/?term=136051 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003309 136051 ZNF786 http://www.ncbi.nlm.nih.gov/gene/?term=136051 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003310 13614 Edn1 http://www.ncbi.nlm.nih.gov/gene/?term=13614 "ET-1, PPET1, preproET " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003311 13618 Ednrb http://www.ncbi.nlm.nih.gov/gene/?term=13618 "ET-B, ET-BR, ETR-b, ETb, Sox10m1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003312 13626 Eed http://www.ncbi.nlm.nih.gov/gene/?term=13626 "ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003313 13627 Eef1a1 http://www.ncbi.nlm.nih.gov/gene/?term=13627 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003314 13628 Eef1a2 http://www.ncbi.nlm.nih.gov/gene/?term=13628 "Eef1a, S1, wasted, wst " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003315 13629 Eef2 http://www.ncbi.nlm.nih.gov/gene/?term=13629 Ef-2 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003316 1362 CPD http://www.ncbi.nlm.nih.gov/gene/?term=1362 GP180 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003317 1362 CPD http://www.ncbi.nlm.nih.gov/gene/?term=1362 GP180 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003318 136319 MTPN http://www.ncbi.nlm.nih.gov/gene/?term=136319 "GCDP, V-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003319 136319 MTPN http://www.ncbi.nlm.nih.gov/gene/?term=136319 "GCDP, V-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003320 136319 MTPN http://www.ncbi.nlm.nih.gov/gene/?term=136319 "GCDP, V-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003321 13631 Eef2k http://www.ncbi.nlm.nih.gov/gene/?term=13631 "C86191, eEF-2K " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00003322 1363 CPE http://www.ncbi.nlm.nih.gov/gene/?term=1363 CPH mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003323 1363 CPE http://www.ncbi.nlm.nih.gov/gene/?term=1363 CPH mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003324 13640 Efna5 http://www.ncbi.nlm.nih.gov/gene/?term=13640 "AL-1, AV158822, EFL-5, Ephrin-A5, Epl7, LERK-7, RAGS " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003325 13649 Egfr http://www.ncbi.nlm.nih.gov/gene/?term=13649 "9030024J15Rik, AI552599, Erbb, Errb1, Errp, Wa5, wa-2, wa2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003326 1364 CLDN4 http://www.ncbi.nlm.nih.gov/gene/?term=1364 "CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003327 1364 CLDN4 http://www.ncbi.nlm.nih.gov/gene/?term=1364 "CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003328 136541 PRSS58 http://www.ncbi.nlm.nih.gov/gene/?term=136541 "PRSS1, TRY1, TRYX3, UNQ2540 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003329 13654 Egr2 http://www.ncbi.nlm.nih.gov/gene/?term=13654 "Egr-2, Krox-20, Krox20, NGF1-B, Zfp-25, Zfp-6 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003330 13655 Egr3 http://www.ncbi.nlm.nih.gov/gene/?term=13655 Pilot mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003331 1365 CLDN3 http://www.ncbi.nlm.nih.gov/gene/?term=1365 "C7orf1, CPE-R2, CPETR2, HRVP1, RVP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003332 1365 CLDN3 http://www.ncbi.nlm.nih.gov/gene/?term=1365 "C7orf1, CPE-R2, CPETR2, HRVP1, RVP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003333 136647 MPLKIP http://www.ncbi.nlm.nih.gov/gene/?term=136647 "ABHS, C7orf11, ORF20, TTD4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003334 136647 MPLKIP http://www.ncbi.nlm.nih.gov/gene/?term=136647 "ABHS, C7orf11, ORF20, TTD4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003335 13664 Eif1a http://www.ncbi.nlm.nih.gov/gene/?term=13664 "C76390, Ef1a, Eftu, Eif4c, eIF-1A, eIF-4C " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003336 13664 Eif1a http://www.ncbi.nlm.nih.gov/gene/?term=13664 "C76390, Ef1a, Eftu, Eif4c, eIF-1A, eIF-4C " mRNA Mus musculus 22945799 Synapse Brain RT-PCR|Immunoprecipitation "Fig. 5 a Detection of KIF1Bb in purified mouse synaptoneurosomes. KIF1Bb is detected in total lysates from the cortex (T; 5 lg total protein) and is enriched in a sample of synaptoneurosomes purified from the cortex (S; 5 lg). The analysis, by RT-PCR, revealed the presence of Arc (activity regulated cytoskeleton-associated protein) mRNA (Fig. 8c), a well-known, dendritically localized mRNA [43-45]. Interestingly, Calmodulin mRNA was also part of this complex. Both were specifically found in the KIF1Bb-immunoprecipitated complex, but not in the negative control reaction (Fig. 8c, compare lanes 2 and 3). The specific association of Arc and Calmodulin mRNAs with the KIF1Bb-containing complex is further supported by the absence of non-synaptically or other synaptically localized mRNAs such as eEIF1a and aCaMKII (Fig. 8c). These observations would suggest the participation of KIF1Bb in RNP particles in association with at least two dendritically targeted mRNAs, Arc and CaM. " RLID00003337 13666 Eif2ak3 http://www.ncbi.nlm.nih.gov/gene/?term=13666 "Pek, Perk " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003338 13669 Eif3a http://www.ncbi.nlm.nih.gov/gene/?term=13669 "A830012B05Rik, Csma, Eif3, Eif3s10, mKIAA0139 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003339 13669 Eif3a http://www.ncbi.nlm.nih.gov/gene/?term=13669 "A830012B05Rik, Csma, Eif3, Eif3s10, mKIAA0139 " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00003340 1366 CLDN7 http://www.ncbi.nlm.nih.gov/gene/?term=1366 "CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003341 1366 CLDN7 http://www.ncbi.nlm.nih.gov/gene/?term=1366 "CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003342 1368 CPM http://www.ncbi.nlm.nih.gov/gene/?term=1368 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003343 1368 CPM http://www.ncbi.nlm.nih.gov/gene/?term=1368 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003344 13690 Eif4g2 http://www.ncbi.nlm.nih.gov/gene/?term=13690 "DAP-5, E130105L11Rik, Nat1, Natm1, p97 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003345 136 ADORA2B http://www.ncbi.nlm.nih.gov/gene/?term=136 ADORA2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003346 136 ADORA2B http://www.ncbi.nlm.nih.gov/gene/?term=136 ADORA2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003347 136 ADORA2B http://www.ncbi.nlm.nih.gov/gene/?term=136 ADORA2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003348 137075 CLDN23 http://www.ncbi.nlm.nih.gov/gene/?term=137075 "CLDNL, hCG1646163 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003349 1370 CPN2 http://www.ncbi.nlm.nih.gov/gene/?term=1370 ACBP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003350 13711 Elf5 http://www.ncbi.nlm.nih.gov/gene/?term=13711 "ESE-2, ESE-5, ESE-5. " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003351 13722 Aimp1 http://www.ncbi.nlm.nih.gov/gene/?term=13722 "9830137A06Rik, AIMP1/p43, EMAPII, Emap2, Scye1, p43 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003352 13730 Emp1 http://www.ncbi.nlm.nih.gov/gene/?term=13730 "I-8-09, TMP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003353 137392 FAM92A1 http://www.ncbi.nlm.nih.gov/gene/?term=137392 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003354 1373 CPS1 http://www.ncbi.nlm.nih.gov/gene/?term=1373 "CPSASE1, PHN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003355 1373 CPS1 http://www.ncbi.nlm.nih.gov/gene/?term=1373 "CPSASE1, PHN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003356 1373 CPS1 http://www.ncbi.nlm.nih.gov/gene/?term=1373 "CPSASE1, PHN " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003357 1374 CPT1A http://www.ncbi.nlm.nih.gov/gene/?term=1374 "CPT1, CPT1-L, L-CPT1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003358 1374 CPT1A http://www.ncbi.nlm.nih.gov/gene/?term=1374 "CPT1, CPT1-L, L-CPT1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003359 1374 CPT1A http://www.ncbi.nlm.nih.gov/gene/?term=1374 "CPT1, CPT1-L, L-CPT1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003360 137695 TMEM68 http://www.ncbi.nlm.nih.gov/gene/?term=137695 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003361 137695 TMEM68 http://www.ncbi.nlm.nih.gov/gene/?term=137695 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003362 1376 CPT2 http://www.ncbi.nlm.nih.gov/gene/?term=1376 "CPT1, CPTASE, IIAE4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003363 1376 CPT2 http://www.ncbi.nlm.nih.gov/gene/?term=1376 "CPT1, CPTASE, IIAE4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003364 137886 UBXN2B http://www.ncbi.nlm.nih.gov/gene/?term=137886 p37 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003365 137886 UBXN2B http://www.ncbi.nlm.nih.gov/gene/?term=137886 p37 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003366 137886 UBXN2B http://www.ncbi.nlm.nih.gov/gene/?term=137886 p37 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003367 1378 CR1 http://www.ncbi.nlm.nih.gov/gene/?term=1378 "C3BR, C4BR, CD35, KN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003368 1378 CR1 http://www.ncbi.nlm.nih.gov/gene/?term=1378 "C3BR, C4BR, CD35, KN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003369 137964 GPAT4 http://www.ncbi.nlm.nih.gov/gene/?term=137964 "1-AGPAT 6, AGPAT6, LPAAT-zeta, LPAATZ, TSARG7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003370 137964 GPAT4 http://www.ncbi.nlm.nih.gov/gene/?term=137964 "1-AGPAT 6, AGPAT6, LPAAT-zeta, LPAATZ, TSARG7 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003371 13798 En1 http://www.ncbi.nlm.nih.gov/gene/?term=13798 "En-1, Mo-en.1 " mRNA Mus musculus 17399993 Dendrite Ventral midBrain In situ hybridization "Here we report the presence of Engrailed protein and En1 mRNA in proximal dendrites of these neurons and of En1 mRNA in ventral midbrain synaptoneurosomes. In contrast, the mRNA of En2 and HPRT (hypoxanthine phosphoribosyltransferase; a well-expressed soma-restricted mRNA) in the SN and VTA (Figs. 1G-J) are confined to the cell body, which confirms the specificity of En1 mRNA dendritic staining. This finding, along with the absence of En2 mRNA in SNSs, confirms the in situ hybridization data and establishes that En1 mRNA is transported into the dendrites of ventral midbrain neurons. " RLID00003372 1379 CR1L http://www.ncbi.nlm.nih.gov/gene/?term=1379 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003373 13800 Enah http://www.ncbi.nlm.nih.gov/gene/?term=13800 "Mena, NDPP-1, Ndpp1, WBP8 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003374 13801 Enam http://www.ncbi.nlm.nih.gov/gene/?term=13801 abte mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003375 13803 Enc1 http://www.ncbi.nlm.nih.gov/gene/?term=13803 "Nrpb, PIG10 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003376 13804 Endog http://www.ncbi.nlm.nih.gov/gene/?term=13804 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003377 13804 Endog http://www.ncbi.nlm.nih.gov/gene/?term=13804 mRNA Mus musculus 15280156 Cytosol kidney In situ hybridization In situ hybridization and immunohistochemical studies localized the increased expression of Endo G mRNA to the cytosolic compartment and Endo G protein to the nuclear compartment of proximal tubules in cisplatin-treated mice. RLID00003378 138050 HGSNAT http://www.ncbi.nlm.nih.gov/gene/?term=138050 "HGNAT, MPS3C, RP73, TMEM76 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003379 13806 Eno1 http://www.ncbi.nlm.nih.gov/gene/?term=13806 "0610008I15, AL022784, Eno-1, MBP-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003380 13807 Eno2 http://www.ncbi.nlm.nih.gov/gene/?term=13807 "AI837106, D6Ertd375e, Eno-2, NSE " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003381 1380 CR2 http://www.ncbi.nlm.nih.gov/gene/?term=1380 "C3DR, CD21, CR, CVID7, SLEB9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003382 138151 NACC2 http://www.ncbi.nlm.nih.gov/gene/?term=138151 "BEND9, BTBD14, BTBD14A, BTBD31, NAC-2, RBB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003383 138199 CARNMT1 http://www.ncbi.nlm.nih.gov/gene/?term=138199 "C9orf41, UPF0586 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003384 138199 CARNMT1 http://www.ncbi.nlm.nih.gov/gene/?term=138199 "C9orf41, UPF0586 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003385 13822 Epb41l2 http://www.ncbi.nlm.nih.gov/gene/?term=13822 "4.1G, AW555191, D10Ertd398e, Epb4.1l2, NBL2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003386 13823 Epb41l3 http://www.ncbi.nlm.nih.gov/gene/?term=13823 "4.1B, DAL1P, Dal1, Epb4.1l3, NBL3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003387 138241 C9orf85 http://www.ncbi.nlm.nih.gov/gene/?term=138241 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003388 13829 Dmtn http://www.ncbi.nlm.nih.gov/gene/?term=13829 "AI325486, Epb4.9, Epb49, dematin " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003389 1382 CRABP2 http://www.ncbi.nlm.nih.gov/gene/?term=1382 "CRABP-II, RBP6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003390 13839 Epha5 http://www.ncbi.nlm.nih.gov/gene/?term=13839 "AI854630, AW125296, Cek7, Ehk1, Els1, Hek7, Rek7, bsk " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003391 13841 Epha7 http://www.ncbi.nlm.nih.gov/gene/?term=13841 "Cek11, Ebk, Ehk3, Hek11, Mdk1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003392 13841 Epha7 http://www.ncbi.nlm.nih.gov/gene/?term=13841 "Cek11, Ebk, Ehk3, Hek11, Mdk1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003393 138428 PTRH1 http://www.ncbi.nlm.nih.gov/gene/?term=138428 "C9orf115, PTH1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003394 1384 CRAT http://www.ncbi.nlm.nih.gov/gene/?term=1384 CAT1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003395 138639 PTPDC1 http://www.ncbi.nlm.nih.gov/gene/?term=138639 PTP9Q22 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003396 138639 PTPDC1 http://www.ncbi.nlm.nih.gov/gene/?term=138639 PTP9Q22 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003397 13865 Nr2f1 http://www.ncbi.nlm.nih.gov/gene/?term=13865 "COUP-TF1, COUP-TFI, COUPTFA, EAR3, Erbal3, SVP44, Tcfcoup1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003398 13869 Erbb4 http://www.ncbi.nlm.nih.gov/gene/?term=13869 "Her4, c-erbB-4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003399 13870 Ercc1 http://www.ncbi.nlm.nih.gov/gene/?term=13870 Ercc-1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003400 138716 RPP25L http://www.ncbi.nlm.nih.gov/gene/?term=138716 "C9orf23, bA296L22.5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003401 13875 Erf http://www.ncbi.nlm.nih.gov/gene/?term=13875 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003402 1387 CREBBP http://www.ncbi.nlm.nih.gov/gene/?term=1387 "CBP, KAT3A, RSTS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003403 1387 CREBBP http://www.ncbi.nlm.nih.gov/gene/?term=1387 "CBP, KAT3A, RSTS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003404 1387 CREBBP http://www.ncbi.nlm.nih.gov/gene/?term=1387 "CBP, KAT3A, RSTS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003405 1389 CREBL2 http://www.ncbi.nlm.nih.gov/gene/?term=1389 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003406 1389 CREBL2 http://www.ncbi.nlm.nih.gov/gene/?term=1389 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003407 1390 CREM http://www.ncbi.nlm.nih.gov/gene/?term=1390 "CREM-2, ICER, hCREM-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003408 1390 CREM http://www.ncbi.nlm.nih.gov/gene/?term=1390 "CREM-2, ICER, hCREM-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003409 139105 BEND2 http://www.ncbi.nlm.nih.gov/gene/?term=139105 CXorf20 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003410 139105 BEND2 http://www.ncbi.nlm.nih.gov/gene/?term=139105 CXorf20 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003411 139231 FAM199X http://www.ncbi.nlm.nih.gov/gene/?term=139231 CXorf39 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003412 13929 Amz2 http://www.ncbi.nlm.nih.gov/gene/?term=13929 "AA408420, ESTM12, X83328 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003413 1392 CRH http://www.ncbi.nlm.nih.gov/gene/?term=1392 "CRF, CRH1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003414 139322 APOOL http://www.ncbi.nlm.nih.gov/gene/?term=139322 "CXorf33, FAM121A, Mic27, UNQ8193 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003415 139322 APOOL http://www.ncbi.nlm.nih.gov/gene/?term=139322 "CXorf33, FAM121A, Mic27, UNQ8193 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003416 139322 APOOL http://www.ncbi.nlm.nih.gov/gene/?term=139322 "CXorf33, FAM121A, Mic27, UNQ8193 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003417 139341 FUNDC1 http://www.ncbi.nlm.nih.gov/gene/?term=139341 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003418 1393 CRHBP http://www.ncbi.nlm.nih.gov/gene/?term=1393 "CRF-BP, CRFBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003419 139422 MAGEB10 http://www.ncbi.nlm.nih.gov/gene/?term=139422 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003420 139422 MAGEB10 http://www.ncbi.nlm.nih.gov/gene/?term=139422 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003421 13957 X83313 http://www.ncbi.nlm.nih.gov/gene/?term=13957 ESTM4 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003422 139596 UPRT http://www.ncbi.nlm.nih.gov/gene/?term=139596 "FUR1, UPP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003423 139596 UPRT http://www.ncbi.nlm.nih.gov/gene/?term=139596 "FUR1, UPP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003424 1396 CRIP1 http://www.ncbi.nlm.nih.gov/gene/?term=1396 "CRHP, CRIP, CRP-1, CRP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003425 1396 CRIP1 http://www.ncbi.nlm.nih.gov/gene/?term=1396 "CRHP, CRIP, CRP-1, CRP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003426 139716 GAB3 http://www.ncbi.nlm.nih.gov/gene/?term=139716 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003427 1397 CRIP2 http://www.ncbi.nlm.nih.gov/gene/?term=1397 "CRIP, CRP2, ESP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003428 139818 DOCK11 http://www.ncbi.nlm.nih.gov/gene/?term=139818 "ACG, ZIZ2, bB128O4.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003429 139886 SPIN4 http://www.ncbi.nlm.nih.gov/gene/?term=139886 TDRD28 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003430 1398 CRK http://www.ncbi.nlm.nih.gov/gene/?term=1398 "CRKII, p38 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003431 13990 Smarcad1 http://www.ncbi.nlm.nih.gov/gene/?term=13990 "AV081750, AW226546, D6Pas1, Etl1, mKIAA1122 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003432 1399 CRKL http://www.ncbi.nlm.nih.gov/gene/?term=1399 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003433 1399 CRKL http://www.ncbi.nlm.nih.gov/gene/?term=1399 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003434 14000 Drosha http://www.ncbi.nlm.nih.gov/gene/?term=14000 "1110013A17Rik, AI874853, Etohi2, Rn3, Rnasen " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003435 14004 Chchd2 http://www.ncbi.nlm.nih.gov/gene/?term=14004 "AL033347, Etohi6 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003436 14008 Etv2 http://www.ncbi.nlm.nih.gov/gene/?term=14008 Etsrp71 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003437 14017 Evi2a http://www.ncbi.nlm.nih.gov/gene/?term=14017 "AW491894, Evi-2, Evi2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003438 14020 Evi5 http://www.ncbi.nlm.nih.gov/gene/?term=14020 NB4S mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003439 14030 Ewsr1 http://www.ncbi.nlm.nih.gov/gene/?term=14030 "Ews, Ewsh " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003440 14042 Ext1 http://www.ncbi.nlm.nih.gov/gene/?term=14042 AA409028 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003441 140459 ASB6 http://www.ncbi.nlm.nih.gov/gene/?term=140459 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003442 140459 ASB6 http://www.ncbi.nlm.nih.gov/gene/?term=140459 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003443 140459 ASB6 http://www.ncbi.nlm.nih.gov/gene/?term=140459 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003444 140460 ASB7 http://www.ncbi.nlm.nih.gov/gene/?term=140460 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003445 140461 ASB8 http://www.ncbi.nlm.nih.gov/gene/?term=140461 PP14212 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003446 140465 MYL6B http://www.ncbi.nlm.nih.gov/gene/?term=140465 MLC1SA mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003447 140467 ZNF358 http://www.ncbi.nlm.nih.gov/gene/?term=140467 ZFEND mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003448 140486 Igf2bp1 http://www.ncbi.nlm.nih.gov/gene/?term=140486 "AL024068, AW549074, CRD-BP, Crdbp, D030026A21Rik, D11Moh40e, D11Moh45, IMP-1, Neilsen, ZBP-1, Zbp1, mir-3063 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003449 140486 Igf2bp1 http://www.ncbi.nlm.nih.gov/gene/?term=140486 "AL024068, AW549074, CRD-BP, Crdbp, D030026A21Rik, D11Moh40e, D11Moh45, IMP-1, Neilsen, ZBP-1, Zbp1, mir-3063 " mRNA Mus musculus 10875929 Cell leading edge NIH 3T3 cell In situ hybridization "The results show that the distribution of full-length H19 RNA is similar to that of IMP-1 (21) by being either evenly distributed in areas with confluent growth-arrested cells (88% of transfected cells) or, as illustrated in Fig.8 B, localized to the leading edge of lamellipodia and perinuclear regions in dispersed proliferating cells (42% of transfected cells). " RLID00003450 140486 Igf2bp1 http://www.ncbi.nlm.nih.gov/gene/?term=140486 "AL024068, AW549074, CRD-BP, Crdbp, D030026A21Rik, D11Moh40e, D11Moh45, IMP-1, Neilsen, ZBP-1, Zbp1, mir-3063 " mRNA Mus musculus 10875929 Lamellipodium NIH 3T3 cell In situ hybridization "The results show that the distribution of full-length H19 RNA is similar to that of IMP-1 (21) by being either evenly distributed in areas with confluent growth-arrested cells (88% of transfected cells) or, as illustrated in Fig.8 B, localized to the leading edge of lamellipodia and perinuclear regions in dispersed proliferating cells (42% of transfected cells). " RLID00003451 140486 Igf2bp1 http://www.ncbi.nlm.nih.gov/gene/?term=140486 "AL024068, AW549074, CRD-BP, Crdbp, D030026A21Rik, D11Moh40e, D11Moh45, IMP-1, Neilsen, ZBP-1, Zbp1, mir-3063 " mRNA Mus musculus 10875929 Perinuclear NIH 3T3 cell In situ hybridization "The results show that the distribution of full-length H19 RNA is similar to that of IMP-1 (21) by being either evenly distributed in areas with confluent growth-arrested cells (88% of transfected cells) or, as illustrated in Fig.8 B, localized to the leading edge of lamellipodia and perinuclear regions in dispersed proliferating cells (42% of transfected cells). " RLID00003452 14048 Eya1 http://www.ncbi.nlm.nih.gov/gene/?term=14048 bor mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003453 140492 Kcnn2 http://www.ncbi.nlm.nih.gov/gene/?term=140492 "KCa2.2, SK2, SKCA2, bc, fri " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003454 1404 HAPLN1 http://www.ncbi.nlm.nih.gov/gene/?term=1404 "CRT1, CRTL1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003455 140545 RNF32 http://www.ncbi.nlm.nih.gov/gene/?term=140545 "FKSG33, HSD15, LMBR2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003456 140564 APOBEC3D http://www.ncbi.nlm.nih.gov/gene/?term=140564 "A3DE, APOBEC3E, ARP6, APOBEC3D " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003457 140564 APOBEC3D http://www.ncbi.nlm.nih.gov/gene/?term=140564 "A3DE, APOBEC3E, ARP6, APOBEC3D " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003458 14056 Ezh2 http://www.ncbi.nlm.nih.gov/gene/?term=14056 "Enx-1, Enx1h, KMT6, mKIAA4065 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003459 140576 S100A16 http://www.ncbi.nlm.nih.gov/gene/?term=140576 "AAG13, DT1P1A7, S100F " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003460 14057 Sfxn1 http://www.ncbi.nlm.nih.gov/gene/?term=14057 "2810002O05Rik, A930015P12Rik, f " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003461 14057 Sfxn1 http://www.ncbi.nlm.nih.gov/gene/?term=14057 "2810002O05Rik, A930015P12Rik, f " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003462 14061 F2 http://www.ncbi.nlm.nih.gov/gene/?term=14061 "Cf-2, Cf2, FII " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003463 14062 F2r http://www.ncbi.nlm.nih.gov/gene/?term=14062 "AI482343, Cf2r, Par1, ThrR " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003464 140630 Ube4a http://www.ncbi.nlm.nih.gov/gene/?term=140630 "4732444G18Rik, 9930123J21Rik, UFD2b " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003465 140680 C20orf96 http://www.ncbi.nlm.nih.gov/gene/?term=140680 dJ1103G7.2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003466 140688 NOL4L http://www.ncbi.nlm.nih.gov/gene/?term=140688 "C20orf112, C20orf113, dJ1184F4.2, dJ1184F4.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003467 140691 TRIM69 http://www.ncbi.nlm.nih.gov/gene/?term=140691 "HSD-34, HSD34, RNF36, Trif " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003468 140691 TRIM69 http://www.ncbi.nlm.nih.gov/gene/?term=140691 "HSD-34, HSD34, RNF36, Trif " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003469 1406 CRX http://www.ncbi.nlm.nih.gov/gene/?term=1406 "CORD2, CRD, LCA7, OTX3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003470 1406 CRX http://www.ncbi.nlm.nih.gov/gene/?term=1406 "CORD2, CRD, LCA7, OTX3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003471 140707 BRI3BP http://www.ncbi.nlm.nih.gov/gene/?term=140707 "BNAS1, HCCR-1, HCCR-2, HCCRBP-1, KG19 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003472 14070 F8a http://www.ncbi.nlm.nih.gov/gene/?term=14070 "AI852759, DXUcsf11, F8a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003473 140710 SOGA1 http://www.ncbi.nlm.nih.gov/gene/?term=140710 "C20orf117, KIAA0889, SOGA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003474 140735 DYNLL2 http://www.ncbi.nlm.nih.gov/gene/?term=140735 "DNCL1B, Dlc2, RSPH22 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003475 140735 DYNLL2 http://www.ncbi.nlm.nih.gov/gene/?term=140735 "DNCL1B, Dlc2, RSPH22 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003476 140738 TMEM37 http://www.ncbi.nlm.nih.gov/gene/?term=140738 "PR, PR1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003477 140739 UBE2F http://www.ncbi.nlm.nih.gov/gene/?term=140739 NCE2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003478 140742 Sesn1 http://www.ncbi.nlm.nih.gov/gene/?term=140742 "1110002G11Rik, AU044290, Pa26, Sest1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003479 140767 NRSN1 http://www.ncbi.nlm.nih.gov/gene/?term=140767 "VMP, p24 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003480 140767 NRSN1 http://www.ncbi.nlm.nih.gov/gene/?term=140767 "VMP, p24 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003481 140780 Bmp2k http://www.ncbi.nlm.nih.gov/gene/?term=140780 "4933417M22Rik, AA673486, AV128808, BIKE " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003482 1407 CRY1 http://www.ncbi.nlm.nih.gov/gene/?term=1407 PHLL1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003483 140803 TRPM6 http://www.ncbi.nlm.nih.gov/gene/?term=140803 "CHAK2, HMGX, HOMG, HOMG1, HSH " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003484 140803 TRPM6 http://www.ncbi.nlm.nih.gov/gene/?term=140803 "CHAK2, HMGX, HOMG, HOMG1, HSH " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003485 140809 SRXN1 http://www.ncbi.nlm.nih.gov/gene/?term=140809 "C20orf139, Npn3, SRX, SRX1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003486 140809 SRXN1 http://www.ncbi.nlm.nih.gov/gene/?term=140809 "C20orf139, Npn3, SRX, SRX1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003487 140810 Ttbk2 http://www.ncbi.nlm.nih.gov/gene/?term=140810 "2610507N02Rik, AI326283, B930008N24Rik, TTK, Ttbk, Ttbk1, mKIAA0847 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003488 140823 ROMO1 http://www.ncbi.nlm.nih.gov/gene/?term=140823 "C20orf52, MTGM, MTGMP, bA353C18.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003489 140831 ZSWIM3 http://www.ncbi.nlm.nih.gov/gene/?term=140831 "C20orf164, PPP1R174 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003490 14083 Ptk2 http://www.ncbi.nlm.nih.gov/gene/?term=14083 "FAK, FRNK, Fadk, mKIAA4203, p125FAK " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003491 14085 Fah http://www.ncbi.nlm.nih.gov/gene/?term=14085 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003492 140883 ZNF280B http://www.ncbi.nlm.nih.gov/gene/?term=140883 "5'OY11.1, D87009.C22.3, SUHW2, ZNF279, ZNF632 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003493 140883 ZNF280B http://www.ncbi.nlm.nih.gov/gene/?term=140883 "5'OY11.1, D87009.C22.3, SUHW2, ZNF279, ZNF632 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003494 140883 ZNF280B http://www.ncbi.nlm.nih.gov/gene/?term=140883 "5'OY11.1, D87009.C22.3, SUHW2, ZNF279, ZNF632 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003495 14088 Fancc http://www.ncbi.nlm.nih.gov/gene/?term=14088 "Facc, mir-3074-1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003496 140890 SREK1 http://www.ncbi.nlm.nih.gov/gene/?term=140890 "SFRS12, SRrp508, SRrp86 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003497 140901 STK35 http://www.ncbi.nlm.nih.gov/gene/?term=140901 "CLIK1L1, STK35 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003498 140901 STK35 http://www.ncbi.nlm.nih.gov/gene/?term=140901 "CLIK1, STK35L1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003499 140917 Dclre1b http://www.ncbi.nlm.nih.gov/gene/?term=140917 "AI452214, Apollo, SNMIB, mSNM1B " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003500 140931 Hnrnph1 http://www.ncbi.nlm.nih.gov/gene/?term=140931 "Hnrph, Hnrph1 " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00003501 14105 Srsf10 http://www.ncbi.nlm.nih.gov/gene/?term=14105 "FUSIP2, Fusip1, NSSR1, NSSR2, Nssr, SRrp40, Sfrs13a, Srsf13a, TASR, TASR1, TASR2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003502 14105 Srsf10 http://www.ncbi.nlm.nih.gov/gene/?term=14105 "FUSIP2, Fusip1, NSSR1, NSSR2, Nssr, SRrp40, Sfrs13a, Srsf13a, TASR, TASR1, TASR2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003503 1410 CRYAB http://www.ncbi.nlm.nih.gov/gene/?term=1410 "CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003504 14115 Fbln2 http://www.ncbi.nlm.nih.gov/gene/?term=14115 "5730577E14Rik, FIBL-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003505 1411 CRYBA1 http://www.ncbi.nlm.nih.gov/gene/?term=1411 "CRYB1, CTRCT10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003506 1413 CRYBA4 http://www.ncbi.nlm.nih.gov/gene/?term=1413 "CTRCT23, MCOPCT4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003507 14155 Fem1b http://www.ncbi.nlm.nih.gov/gene/?term=14155 mKIAA0396 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003508 14158 Fer http://www.ncbi.nlm.nih.gov/gene/?term=14158 "AV082135, C330004K01Rikt, Fert2, Fer " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003509 14160 Lgr5 http://www.ncbi.nlm.nih.gov/gene/?term=14160 "FEX, Gpr49 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003510 14161 Fga http://www.ncbi.nlm.nih.gov/gene/?term=14161 "ENSMUSG00000059807, Fib " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003511 14163 Fgd1 http://www.ncbi.nlm.nih.gov/gene/?term=14163 ZFYVE3 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003512 14167 Fgf12 http://www.ncbi.nlm.nih.gov/gene/?term=14167 "AV114868, B230343J05Rik, FGF-12, FHF-1, Fhf1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003513 1416 CRYBB2P1 http://www.ncbi.nlm.nih.gov/gene/?term=1416 CRYB2B lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003514 14176 Fgf5 http://www.ncbi.nlm.nih.gov/gene/?term=14176 "Fgf-5, HBGF-5, angora, go " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003515 14186 Fgfr4 http://www.ncbi.nlm.nih.gov/gene/?term=14186 Fgfr-4 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003516 14201 Fhl3 http://www.ncbi.nlm.nih.gov/gene/?term=14201 SLIM2 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003517 14211 Smc2 http://www.ncbi.nlm.nih.gov/gene/?term=14211 "5730502P04Rik, AI255214, AW545314, CAP-E, CAPE, Fin16, SMC-2l1, Smc2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003518 14217174 SPRRNA.42 http://www.ncbi.nlm.nih.gov/gene/?term=14217174 SPRRNA.42 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.42 RLID00003519 14217228 SPRRNA.46 http://www.ncbi.nlm.nih.gov/gene/?term=14217228 SPRRNA.46 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.46 RLID00003520 14217287 SPRRNA.45 http://www.ncbi.nlm.nih.gov/gene/?term=14217287 SPRRNA.45 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.45 RLID00003521 14217299 SPRRNA.47 http://www.ncbi.nlm.nih.gov/gene/?term=14217299 SPRRNA.47 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.47 RLID00003522 14217300 SPRRNA.48 http://www.ncbi.nlm.nih.gov/gene/?term=14217300 SPRRNA.48 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.48 RLID00003523 14217302 SPRRNA.52 http://www.ncbi.nlm.nih.gov/gene/?term=14217302 SPRRNA.52 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.52 RLID00003524 14217303 SPRRNA.50 http://www.ncbi.nlm.nih.gov/gene/?term=14217303 SPRRNA.50 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.50 RLID00003525 14217304 SPRRNA.51 http://www.ncbi.nlm.nih.gov/gene/?term=14217304 SPRRNA.51 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.51 RLID00003526 14217306 SPRRNA.43 http://www.ncbi.nlm.nih.gov/gene/?term=14217306 SPRRNA.43 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.43 RLID00003527 14217307 SPRRNA.44 http://www.ncbi.nlm.nih.gov/gene/?term=14217307 SPRRNA.44 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.44 RLID00003528 14217308 SPRRNA.49 http://www.ncbi.nlm.nih.gov/gene/?term=14217308 SPRRNA.49 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.49 RLID00003529 14217409 SPBTRNASER.05 http://www.ncbi.nlm.nih.gov/gene/?term=14217409 SPBTRNASER.05 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNASER.05 RLID00003530 14217707 SPBTRNASER.06 http://www.ncbi.nlm.nih.gov/gene/?term=14217707 SPBTRNASER.06 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNASER.06 RLID00003531 14218195 SPATRNAPRO.02 http://www.ncbi.nlm.nih.gov/gene/?term=14218195 SPATRNAPRO.02 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPATRNAPRO.02 RLID00003532 14219 Ctgf http://www.ncbi.nlm.nih.gov/gene/?term=14219 "Ccn2, Fisp12, Hcs24, fisp-12 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003533 14225 Fkbp1a http://www.ncbi.nlm.nih.gov/gene/?term=14225 "FKBP12, Fkbp, Fkbp1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003534 14228 Fkbp4 http://www.ncbi.nlm.nih.gov/gene/?term=14228 "59kDa, AL022792, AW208983, FKBP-4, FKBP-52, FKBP52, FKPB52, p59 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003535 14231 Fkbp7 http://www.ncbi.nlm.nih.gov/gene/?term=14231 "23kDa, FKBP-7, FKBP23 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003536 14254 Flt1 http://www.ncbi.nlm.nih.gov/gene/?term=14254 "AI323757, Flt-1, VEGFR-1, VEGFR1, sFlt1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003537 14262 Fmo3 http://www.ncbi.nlm.nih.gov/gene/?term=14262 AW111792 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003538 14265 Fmr1 http://www.ncbi.nlm.nih.gov/gene/?term=14265 "FMRP, Fmr-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003539 14265 Fmr1 http://www.ncbi.nlm.nih.gov/gene/?term=14265 "FMRP, Fmr-1 " mRNA Mus musculus 18539120 Dendrite Neuron Fluorescence in situ hybridization Histogram showing dendritic Fmr1 mRNA abundance in KLC dominant negative-transfected neurons (n=13-15; *p<0.005; mean±SEM). Images above bars represent dendritic regions from images outlined at left. RLID00003540 142678 MIB2 http://www.ncbi.nlm.nih.gov/gene/?term=142678 "ZZANK1, ZZZ5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003541 142678 MIB2 http://www.ncbi.nlm.nih.gov/gene/?term=142678 "ZZANK1, ZZZ5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003542 142679 DUSP19 http://www.ncbi.nlm.nih.gov/gene/?term=142679 "DUSP17, LMWDSP3, SKRP1, TS-DSP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003543 142679 DUSP19 http://www.ncbi.nlm.nih.gov/gene/?term=142679 "DUSP17, LMWDSP3, SKRP1, TS-DSP1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003544 14268 Fn1 http://www.ncbi.nlm.nih.gov/gene/?term=14268 "E330027I09, Fn, Fn-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003545 14269 Fnbp1 http://www.ncbi.nlm.nih.gov/gene/?term=14269 "1110057E06Rik, 2210010H06Rik, FBP1, Fbp17 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003546 14270 Srgap2 http://www.ncbi.nlm.nih.gov/gene/?term=14270 "9930124L22Rik, AI448945, FBP2, Fnbp2, srGAP3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003547 14281 Fos http://www.ncbi.nlm.nih.gov/gene/?term=14281 "D12Rfj1, c-fos, cFos " mRNA Mus musculus 1748285 Nucleus NIH-3T3 cell In situ hybridization|Electron microscopy We have also compared the localization of c-fos transcripts with the speckled nuclear regions that are enriched in snRNPs and the non-snRNP splicing factor SC-35. Direct observations of three-dimensional rotations have revealed a close association between the c-fos transcripts and the nuclear speckles. This study demonstrates a direct link between specific nascent RNA transcripts and nuclear speckles that are enriched in pre-mRNA splicing factors. RLID00003548 14281 Fos http://www.ncbi.nlm.nih.gov/gene/?term=14281 "D12Rfj1, c-fos, cFos " mRNA Mus musculus 1748285 Nucleus NIH-3T3 cell In situ hybridization|Electron microscopy "By using high-voltage electron microscopy, we have found that the c-fos path extends out and comes into direct contact with the nuclear envelope. " RLID00003549 142940 TRUB1 http://www.ncbi.nlm.nih.gov/gene/?term=142940 PUS4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003550 142940 TRUB1 http://www.ncbi.nlm.nih.gov/gene/?term=142940 PUS4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003551 14297 Fxn http://www.ncbi.nlm.nih.gov/gene/?term=14297 "FA, FARR, Frda, X25 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003552 1429 CRYZ http://www.ncbi.nlm.nih.gov/gene/?term=1429 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003553 1429 CRYZ http://www.ncbi.nlm.nih.gov/gene/?term=1429 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003554 1429 CRYZ http://www.ncbi.nlm.nih.gov/gene/?term=1429 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003555 142 PARP1 http://www.ncbi.nlm.nih.gov/gene/?term=142 "ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003556 14302 Frk http://www.ncbi.nlm.nih.gov/gene/?term=14302 "BSK, BSK/IYK, C85044, GTK, RAK " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003557 14313 Fst http://www.ncbi.nlm.nih.gov/gene/?term=14313 "AL033346, FS " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003558 14314 Fstl1 http://www.ncbi.nlm.nih.gov/gene/?term=14314 "AI316791, AW107808, Fstl, TSC-36 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003559 14314 Fstl1 http://www.ncbi.nlm.nih.gov/gene/?term=14314 "AI316791, AW107808, Fstl, TSC-36 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00003560 143187 VTI1A http://www.ncbi.nlm.nih.gov/gene/?term=143187 "MMDS3, MVti1, VTI1RP2, Vti1-rp2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003561 1431 CS http://www.ncbi.nlm.nih.gov/gene/?term=1431 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003562 143244 EIF5AL1 http://www.ncbi.nlm.nih.gov/gene/?term=143244 "EIF5AP1, bA342M3.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003563 143244 EIF5AL1 http://www.ncbi.nlm.nih.gov/gene/?term=143244 "EIF5AP1, bA342M3.3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003564 143244 EIF5AL1 http://www.ncbi.nlm.nih.gov/gene/?term=143244 "EIF5AP1, bA342M3.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003565 14325 Ftl1 http://www.ncbi.nlm.nih.gov/gene/?term=14325 "Ftl, Ftl-1, L-ferritin " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003566 143279 HECTD2 http://www.ncbi.nlm.nih.gov/gene/?term=143279 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003567 143279 HECTD2 http://www.ncbi.nlm.nih.gov/gene/?term=143279 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003568 143279 HECTD2 http://www.ncbi.nlm.nih.gov/gene/?term=143279 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003569 1432 MAPK14 http://www.ncbi.nlm.nih.gov/gene/?term=1432 "CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003570 1432 MAPK14 http://www.ncbi.nlm.nih.gov/gene/?term=1432 "CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003571 1432 MAPK14 http://www.ncbi.nlm.nih.gov/gene/?term=1432 "CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003572 1432 MAPK14 http://www.ncbi.nlm.nih.gov/gene/?term=1432 "CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003573 143379 C10orf82 http://www.ncbi.nlm.nih.gov/gene/?term=143379 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003574 143384 CACUL1 http://www.ncbi.nlm.nih.gov/gene/?term=143384 "C10orf46, CAC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003575 143384 CACUL1 http://www.ncbi.nlm.nih.gov/gene/?term=143384 "C10orf46, CAC1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003576 143384 CACUL1 http://www.ncbi.nlm.nih.gov/gene/?term=143384 "C10orf46, CAC1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003577 143384 CACUL1 http://www.ncbi.nlm.nih.gov/gene/?term=143384 "C10orf46, CAC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003578 14345 Fut4 http://www.ncbi.nlm.nih.gov/gene/?term=14345 "AI451562, CD15, FAL, FucT-IV, LeX, SSEA-1, Ssea1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003579 14349 Fv1 http://www.ncbi.nlm.nih.gov/gene/?term=14349 "Fv-1, Rv-1, Rv1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003580 1434 CSE1L http://www.ncbi.nlm.nih.gov/gene/?term=1434 "CAS, CSE1, XPO2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003581 1434 CSE1L http://www.ncbi.nlm.nih.gov/gene/?term=1434 "CAS, CSE1, XPO2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003582 1434 CSE1L http://www.ncbi.nlm.nih.gov/gene/?term=1434 "CAS, CSE1, XPO2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003583 143570 XRRA1 http://www.ncbi.nlm.nih.gov/gene/?term=143570 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003584 14359 Fxr1 http://www.ncbi.nlm.nih.gov/gene/?term=14359 "1110050J02Rik, 9530073J07Rik, AI851072h, Fxr1p, Fxr1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003585 14365 Fzd3 http://www.ncbi.nlm.nih.gov/gene/?term=14365 "AU020229, D930050A07Rik, Fz3 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003586 14365 Fzd3 http://www.ncbi.nlm.nih.gov/gene/?term=14365 "AU020229, D930050A07Rik, Fz3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003587 143662 MUC15 http://www.ncbi.nlm.nih.gov/gene/?term=143662 "MUC-15, PAS3, PASIII " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003588 143684 FAM76B http://www.ncbi.nlm.nih.gov/gene/?term=143684 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003589 1436 CSF1R http://www.ncbi.nlm.nih.gov/gene/?term=1436 "C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003590 14375 Xrcc6 http://www.ncbi.nlm.nih.gov/gene/?term=14375 "70kDa, G22p1, Ku70 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003591 14376 Ganab http://www.ncbi.nlm.nih.gov/gene/?term=14376 "AU042638, G2an, GluII, mKIAA0088 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003592 143872 ARHGAP42 http://www.ncbi.nlm.nih.gov/gene/?term=143872 GRAF3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003593 143884 CWF19L2 http://www.ncbi.nlm.nih.gov/gene/?term=143884 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003594 143888 KDELC2 http://www.ncbi.nlm.nih.gov/gene/?term=143888 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003595 14389 Gab2 http://www.ncbi.nlm.nih.gov/gene/?term=14389 "AI463667, D130058I17Rik, p97 " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00003596 14390 Gabpa http://www.ncbi.nlm.nih.gov/gene/?term=14390 GABPalpha mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003597 1439 CSF2RB http://www.ncbi.nlm.nih.gov/gene/?term=1439 "CD131, CDw131, IL3RB, IL5RB, SMDP5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003598 143 PARP4 http://www.ncbi.nlm.nih.gov/gene/?term=143 "ADPRTL1, ARTD4, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C, p193 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003599 143 PARP4 http://www.ncbi.nlm.nih.gov/gene/?term=143 "ADPRTL1, ARTD4, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C, p193 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003600 143 PARP4 http://www.ncbi.nlm.nih.gov/gene/?term=143 "ADPRTL1, ARTD4, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C, p193 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003601 14402 Gabrb3 http://www.ncbi.nlm.nih.gov/gene/?term=14402 "A230092K12Rik, AW049585, Cp1, Gabrb-3, beta3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003602 144097 C11orf84 http://www.ncbi.nlm.nih.gov/gene/?term=144097 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003603 144108 SPTY2D1 http://www.ncbi.nlm.nih.gov/gene/?term=144108 Spt2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003604 144110 TMEM86A http://www.ncbi.nlm.nih.gov/gene/?term=144110 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003605 144165 PRICKLE1 http://www.ncbi.nlm.nih.gov/gene/?term=144165 "EPM1B, RILP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003606 144193 AMDHD1 http://www.ncbi.nlm.nih.gov/gene/?term=144193 HMFT1272 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003607 1441 CSF3R http://www.ncbi.nlm.nih.gov/gene/?term=1441 "CD114, GCSFR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003608 14420 Galc http://www.ncbi.nlm.nih.gov/gene/?term=14420 "2310068B06Rik, A930008M05Rik, AW212969, AW413532, Gacy, twi, twitcher " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003609 144233 BCDIN3D http://www.ncbi.nlm.nih.gov/gene/?term=144233 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003610 144233 BCDIN3D http://www.ncbi.nlm.nih.gov/gene/?term=144233 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003611 144245 ALG10B http://www.ncbi.nlm.nih.gov/gene/?term=144245 "ALG10, KCR1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003612 144245 ALG10B http://www.ncbi.nlm.nih.gov/gene/?term=144245 "ALG10, KCR1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003613 14431 Gamt http://www.ncbi.nlm.nih.gov/gene/?term=14431 "AA571402, Spintz1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003614 14432 Gap43 http://www.ncbi.nlm.nih.gov/gene/?term=14432 "B-50, Basp2, GAP-43 " mRNA Mus musculus 26512708 Axon ForeBrain Immunoprecipitation|RIP-Chip The cis-element required for GAP-43 mRNA localization into PNS axons was mapped to the ARE/HuD binding site in its 3' UTR RLID00003615 14433 Gapdh http://www.ncbi.nlm.nih.gov/gene/?term=14433 Gapd mRNA Mus musculus 16874305 Cytoplasm Fibroblast qRT-PCR|Northern blot "Thus, an mRNA localized to the cytoplasm such as Gapdh shows no enrichment relative to CypA, and cytoplasmic and nuclear levels approximately equal 1 (Figure 6A). " RLID00003616 14433 Gapdh http://www.ncbi.nlm.nih.gov/gene/?term=14433 Gapd mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003617 14433 Gapdh http://www.ncbi.nlm.nih.gov/gene/?term=14433 Gapd mRNA Mus musculus 12923260 Ribosome B cell Northern blot "In this report, we use multiple cell fractionation protocols, in combination with cDNA microarray, nuclease protection, and Northern blot analyses, to assess the distribution of mRNAs between free and ER-bound ribosomes. We find a broad representation of mRNAs encoding soluble proteins in the ER fraction, with a subset of such mRNAs displaying substantial ER partitioning. In addition, we present evidence that membrane-bound ribosomes engage in the translation of mRNAs encoding soluble proteins. Single-cell in situ hybridization analysis of the subcellular distribution of mRNAs encoding ER-localized and soluble proteins identify two overall patterns of mRNA distribution in the cell-endoplasmic reticular and cytosolic. FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells. " RLID00003618 14433 Gapdh http://www.ncbi.nlm.nih.gov/gene/?term=14433 Gapd mRNA Mus musculus 12923260 Ribosome B cell S1 nuclease protection assays "However, and as depicted in Figure 4 (Cytosol), mRNAs encoding GAPDH and LDH were present in both free and membrane-bound polysomes, and mRNAs encoding Hsp90 displayed a high enrichment in the membrane-bound fraction (75%-97%). Such partitioning of mRNAs to the ER was observed in 15 independent experiments using ER derived from Jurkat and J558 cells alike, thus confirming that mRNAs encoding signal-sequence-bearing proteins and mRNAs encoding cytosolic proteins are present on the ER. " RLID00003619 14433 Gapdh http://www.ncbi.nlm.nih.gov/gene/?term=14433 Gapd mRNA Mus musculus 26179904 Cytosol Macrophage qRT-PCR "As expected, the mature IL-1a and Gapdh transcripts were localized to the cytosol, whereas 7SK RNA was confined to the nucleus. " RLID00003620 14433 Gapdh http://www.ncbi.nlm.nih.gov/gene/?term=14433 Gapd mRNA Mus musculus 26464439 Axon Motoneuron In situ hybridization|qRT-PCR For whole transcriptome profiling we used Gapdh for setting the number of PCR cycles for the amplification of somatodendritic and axonal RNA. In line with these qPCRs we detected Gapdh in both compartments of cultured motoneurons by FISH (Figure 7B). RLID00003621 14433 Gapdh http://www.ncbi.nlm.nih.gov/gene/?term=14433 Gapd mRNA Mus musculus 26464439 Somatodendritic compartment Motoneuron In situ hybridization|qRT-PCR For whole transcriptome profiling we used Gapdh for setting the number of PCR cycles for the amplification of somatodendritic and axonal RNA. In line with these qPCRs we detected Gapdh in both compartments of cultured motoneurons by FISH (Figure 7B). RLID00003622 14433 Gapdh http://www.ncbi.nlm.nih.gov/gene/?term=14433 Gapd mRNA Mus musculus 23898399 Nucleus 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00003623 14433 Gapdh http://www.ncbi.nlm.nih.gov/gene/?term=14433 Gapd mRNA Mus musculus 23898399 Cytoplasm 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00003624 14433 Gapdh http://www.ncbi.nlm.nih.gov/gene/?term=14433 Gapd mRNA Mus musculus 12923260 Ribosome J558 cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00003625 144347 FAM101A http://www.ncbi.nlm.nih.gov/gene/?term=144347 CFM2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003626 144348 ZNF664 http://www.ncbi.nlm.nih.gov/gene/?term=144348 "ZFOC1, ZNF176 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003627 144348 ZNF664 http://www.ncbi.nlm.nih.gov/gene/?term=144348 "ZFOC1, ZNF176 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003628 144348 ZNF664 http://www.ncbi.nlm.nih.gov/gene/?term=144348 "ZFOC1, ZNF176 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003629 144363 LYRM5 http://www.ncbi.nlm.nih.gov/gene/?term=144363 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003630 144402 CPNE8 http://www.ncbi.nlm.nih.gov/gene/?term=144402 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003631 144404 TMEM120B http://www.ncbi.nlm.nih.gov/gene/?term=144404 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003632 144423 GLT1D1 http://www.ncbi.nlm.nih.gov/gene/?term=144423 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003633 14450 Gart http://www.ncbi.nlm.nih.gov/gene/?term=14450 "Gaps, Prgs " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003634 1445 CSK http://www.ncbi.nlm.nih.gov/gene/?term=1445 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003635 14460 Gata1 http://www.ncbi.nlm.nih.gov/gene/?term=14460 "Gata-1, Gf-1, eryf1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003636 14467 Gbas http://www.ncbi.nlm.nih.gov/gene/?term=14467 "AV006093, Nipsnap2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003637 144699 FBXL14 http://www.ncbi.nlm.nih.gov/gene/?term=144699 Fbl14 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003638 144699 FBXL14 http://www.ncbi.nlm.nih.gov/gene/?term=144699 Fbl14 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003639 144717 FAM109A http://www.ncbi.nlm.nih.gov/gene/?term=144717 "IPIP27A, SES1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003640 14479 Usp15 http://www.ncbi.nlm.nih.gov/gene/?term=14479 "4921514G19Rik, AI327321, E430033I05Rik, Gcap18 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003641 144809 FAM216B http://www.ncbi.nlm.nih.gov/gene/?term=144809 C13orf30 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003642 144983 HNRNPA1L2 http://www.ncbi.nlm.nih.gov/gene/?term=144983 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003643 145173 B3GLCT http://www.ncbi.nlm.nih.gov/gene/?term=145173 "B3GALTL, B3GTL, B3Glc-T, Gal-T, beta3Glc-T " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003644 145173 B3GLCT http://www.ncbi.nlm.nih.gov/gene/?term=145173 "B3GALTL, B3GTL, B3Glc-T, Gal-T, beta3Glc-T " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003645 145200 LINC00239 http://www.ncbi.nlm.nih.gov/gene/?term=145200 "C14orf72, NCRNA00239 " lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003646 1452 CSNK1A1 http://www.ncbi.nlm.nih.gov/gene/?term=1452 "CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003647 1452 CSNK1A1 http://www.ncbi.nlm.nih.gov/gene/?term=1452 "CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003648 1452 CSNK1A1 http://www.ncbi.nlm.nih.gov/gene/?term=1452 "CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003649 145389 SLC38A6 http://www.ncbi.nlm.nih.gov/gene/?term=145389 "NAT-1, SNAT6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003650 1453 CSNK1D http://www.ncbi.nlm.nih.gov/gene/?term=1453 "ASPS, CKIdelta, FASPS2, HCKID " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003651 145407 C14orf37 http://www.ncbi.nlm.nih.gov/gene/?term=145407 c14_5376 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003652 145447 ABHD12B http://www.ncbi.nlm.nih.gov/gene/?term=145447 "BEM46L3, C14orf29, c14_5314 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003653 14545 Gdap1 http://www.ncbi.nlm.nih.gov/gene/?term=14545 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003654 1454 CSNK1E http://www.ncbi.nlm.nih.gov/gene/?term=1454 "CKIepsilon, HCKIE " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003655 1454 CSNK1E http://www.ncbi.nlm.nih.gov/gene/?term=1454 "CKIepsilon, HCKIE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003656 14554 Gdap9 http://www.ncbi.nlm.nih.gov/gene/?term=14554 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003657 145567 TTC7B http://www.ncbi.nlm.nih.gov/gene/?term=145567 "TTC7L1, c14_5685 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003658 1455 CSNK1G2 http://www.ncbi.nlm.nih.gov/gene/?term=1455 CK1g2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003659 1455 CSNK1G2 http://www.ncbi.nlm.nih.gov/gene/?term=1455 CK1g2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003660 1455 CSNK1G2 http://www.ncbi.nlm.nih.gov/gene/?term=1455 CK1g2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003661 1456 CSNK1G3 http://www.ncbi.nlm.nih.gov/gene/?term=1456 "CKI-gamma 3L, CSNK1G3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003662 1456 CSNK1G3 http://www.ncbi.nlm.nih.gov/gene/?term=1456 "CKI-gamma 3, CSNK1G3L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003663 14570 Arhgdig http://www.ncbi.nlm.nih.gov/gene/?term=14570 "Gdi5, RIP2, Rho-GDI-3, Rho-GDI2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003664 14573 Gdnf http://www.ncbi.nlm.nih.gov/gene/?term=14573 AI385739 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003665 145741 C2CD4A http://www.ncbi.nlm.nih.gov/gene/?term=145741 "FAM148A, NLF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003666 145741 C2CD4A http://www.ncbi.nlm.nih.gov/gene/?term=145741 "FAM148A, NLF1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003667 145741 C2CD4A http://www.ncbi.nlm.nih.gov/gene/?term=145741 "FAM148A, NLF1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003668 145773 FAM81A http://www.ncbi.nlm.nih.gov/gene/?term=145773 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003669 145781 GCOM1 http://www.ncbi.nlm.nih.gov/gene/?term=145781 "GRINL1A, Gcom2, MYZAP, MYZAP-POLR2M, gcom " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003670 145781 GCOM1 http://www.ncbi.nlm.nih.gov/gene/?term=145781 "GRINL1A, Gcom2, MYZAP, MYZAP-POLR2M, gcom " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003671 145781 GCOM1 http://www.ncbi.nlm.nih.gov/gene/?term=145781 "GRINL1A, Gcom2, MYZAP, MYZAP-POLR2M, gcom " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003672 1457 CSNK2A1 http://www.ncbi.nlm.nih.gov/gene/?term=1457 "CK2A1, CKII, CSNK2A3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003673 145853 C15orf61 http://www.ncbi.nlm.nih.gov/gene/?term=145853 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003674 145853 C15orf61 http://www.ncbi.nlm.nih.gov/gene/?term=145853 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003675 14593 Ggps1 http://www.ncbi.nlm.nih.gov/gene/?term=14593 "1810026C22Rik, 9530089B04Rik, AI843169, C79210 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003676 14593 Ggps1 http://www.ncbi.nlm.nih.gov/gene/?term=14593 "1810026C22Rik, 9530089B04Rik, AI843169, C79210 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003677 14593 Ggps1 http://www.ncbi.nlm.nih.gov/gene/?term=14593 "1810026C22Rik, 9530089B04Rik, AI843169, C79210 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003678 14599 Gh http://www.ncbi.nlm.nih.gov/gene/?term=14599 "Gh1b1, Gh " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003679 1459 CSNK2A2 http://www.ncbi.nlm.nih.gov/gene/?term=1459 "CK2A2, CK2alpha', CSNK2A1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003680 1459 CSNK2A2 http://www.ncbi.nlm.nih.gov/gene/?term=1459 "CK2A2, CK2alpha', CSNK2A1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003681 14600 Ghr http://www.ncbi.nlm.nih.gov/gene/?term=14600 "GHBP, GHR/BP " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003682 14603 Gif http://www.ncbi.nlm.nih.gov/gene/?term=14603 AV073125 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003683 146050 ZSCAN29 http://www.ncbi.nlm.nih.gov/gene/?term=146050 "ZNF690, Zfp690 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003684 146050 ZSCAN29 http://www.ncbi.nlm.nih.gov/gene/?term=146050 "ZNF690, Zfp690 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003685 146050 ZSCAN29 http://www.ncbi.nlm.nih.gov/gene/?term=146050 "ZNF690, Zfp690 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003686 1460 CSNK2B http://www.ncbi.nlm.nih.gov/gene/?term=1460 "CK2B, CK2N, CSK2B, G5A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003687 1460 CSNK2B http://www.ncbi.nlm.nih.gov/gene/?term=1460 "CK2B, CK2N, CSK2B, G5A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003688 1460 CSNK2B http://www.ncbi.nlm.nih.gov/gene/?term=1460 "CK2B, CK2N, CSK2B, G5A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003689 14615 Gjc1 http://www.ncbi.nlm.nih.gov/gene/?term=14615 "C130009G16Rik, Cnx45, Cx45, Gja-7, Gja7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003690 146177 VWA3A http://www.ncbi.nlm.nih.gov/gene/?term=146177 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003691 146198 ZFP90 http://www.ncbi.nlm.nih.gov/gene/?term=146198 "FIK, NK10, ZNF756, zfp-90 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003692 146223 CMTM4 http://www.ncbi.nlm.nih.gov/gene/?term=146223 CKLFSF4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003693 14625 Gykl1 http://www.ncbi.nlm.nih.gov/gene/?term=14625 "AI449806, Gk-rs1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003694 14629 Gclc http://www.ncbi.nlm.nih.gov/gene/?term=14629 "D9Wsu168e, GLCL-H, Ggcs-hs, Glclc " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003695 1462 VCAN http://www.ncbi.nlm.nih.gov/gene/?term=1462 "CSPG2, ERVR, GHAP, PG-M, WGN, WGN1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003696 1462 VCAN http://www.ncbi.nlm.nih.gov/gene/?term=1462 "CSPG2, ERVR, GHAP, PG-M, WGN, WGN1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003697 146330 FBXL16 http://www.ncbi.nlm.nih.gov/gene/?term=146330 "C16orf22, Fbl16, c380A1.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003698 14634 Gli3 http://www.ncbi.nlm.nih.gov/gene/?term=14634 "AI854843, AU023367, Bph, GLI3-190, GLI3FL, Pdn, Xt, add " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003699 146439 BICDL2 http://www.ncbi.nlm.nih.gov/gene/?term=146439 BICDR-2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003700 14645 Glul http://www.ncbi.nlm.nih.gov/gene/?term=14645 "GS, Glns " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003701 1464 CSPG4 http://www.ncbi.nlm.nih.gov/gene/?term=1464 "HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003702 14651 Hagh http://www.ncbi.nlm.nih.gov/gene/?term=14651 "BC019817, Glo-2, Glo2, Rsp29 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003703 146540 ZNF785 http://www.ncbi.nlm.nih.gov/gene/?term=146540 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003704 146540 ZNF785 http://www.ncbi.nlm.nih.gov/gene/?term=146540 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003705 146542 ZNF688 http://www.ncbi.nlm.nih.gov/gene/?term=146542 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003706 146556 C16orf89 http://www.ncbi.nlm.nih.gov/gene/?term=146556 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003707 146556 C16orf89 http://www.ncbi.nlm.nih.gov/gene/?term=146556 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003708 14658 Glrb http://www.ncbi.nlm.nih.gov/gene/?term=14658 "AI853901, Glyrb, spa, spastic " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003709 1465 CSRP1 http://www.ncbi.nlm.nih.gov/gene/?term=1465 "CRP, CRP1, CSRP, CYRP, D1S181E, HEL-141, HEL-S-286 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003710 14661 Glud1 http://www.ncbi.nlm.nih.gov/gene/?term=14661 "AI118167, Gdh-X, Glud, Gludl " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003711 1466 CSRP2 http://www.ncbi.nlm.nih.gov/gene/?term=1466 "CRP2, LMO5, SmLIM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003712 14674 Gna13 http://www.ncbi.nlm.nih.gov/gene/?term=14674 "AU024132, AU043124, Galpha13 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003713 14674 Gna13 http://www.ncbi.nlm.nih.gov/gene/?term=14674 "AU024132, AU043124, Galpha13 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003714 14678 Gnai2 http://www.ncbi.nlm.nih.gov/gene/?term=14678 "C76432, Galphai2, Gia, Gnai-2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003715 14679 Gnai3 http://www.ncbi.nlm.nih.gov/gene/?term=14679 "AI158965, AW537698, Galphai3, Gnai-3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003716 14681 Gnao1 http://www.ncbi.nlm.nih.gov/gene/?term=14681 "AW050213, Galphao, Gnao, alphaO " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003717 146862 UNC45B http://www.ncbi.nlm.nih.gov/gene/?term=146862 "CMYA4, CTRCT43, SMUNC45, UNC-45B, UNC45 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003718 146862 UNC45B http://www.ncbi.nlm.nih.gov/gene/?term=146862 "CMYA4, CTRCT43, SMUNC45, UNC-45B, UNC45 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003719 14688 Gnb1 http://www.ncbi.nlm.nih.gov/gene/?term=14688 "AA409223, C77571, Gnb-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003720 146894 CD300LG http://www.ncbi.nlm.nih.gov/gene/?term=146894 "CLM-9, CLM9, NEPMUCIN, TREM-4, TREM4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003721 146894 CD300LG http://www.ncbi.nlm.nih.gov/gene/?term=146894 "CLM-9, CLM9, NEPMUCIN, TREM-4, TREM4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003722 1468 SLC25A10 http://www.ncbi.nlm.nih.gov/gene/?term=1468 DIC mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003723 147007 TMEM199 http://www.ncbi.nlm.nih.gov/gene/?term=147007 "C17orf32, CDG2P, VMA12, VPH2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003724 147007 TMEM199 http://www.ncbi.nlm.nih.gov/gene/?term=147007 "C17orf32, VMA12, VPH2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003725 147015 DHRS13 http://www.ncbi.nlm.nih.gov/gene/?term=147015 SDR7C5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003726 147015 DHRS13 http://www.ncbi.nlm.nih.gov/gene/?term=147015 SDR7C5 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003727 14704 Gng3 http://www.ncbi.nlm.nih.gov/gene/?term=14704 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003728 14705 Bscl2 http://www.ncbi.nlm.nih.gov/gene/?term=14705 "2900097C17Rik, AI046355, Gng3lg " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003729 14707 Gng5 http://www.ncbi.nlm.nih.gov/gene/?term=14707 G(y)5 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003730 14710 Gngt2 http://www.ncbi.nlm.nih.gov/gene/?term=14710 AV096488 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003731 147111 NOTUM http://www.ncbi.nlm.nih.gov/gene/?term=147111 hNOTUM mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003732 147166 TRIM16L http://www.ncbi.nlm.nih.gov/gene/?term=147166 TRIM70 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003733 147166 TRIM16L http://www.ncbi.nlm.nih.gov/gene/?term=147166 TRIM70 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003734 147179 WIPF2 http://www.ncbi.nlm.nih.gov/gene/?term=147179 "WICH, WIRE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003735 147179 WIPF2 http://www.ncbi.nlm.nih.gov/gene/?term=147179 "WICH, WIRE " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003736 147179 WIPF2 http://www.ncbi.nlm.nih.gov/gene/?term=147179 "WICH, WIRE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003737 147184 TMEM99 http://www.ncbi.nlm.nih.gov/gene/?term=147184 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003738 147184 TMEM99 http://www.ncbi.nlm.nih.gov/gene/?term=147184 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003739 1471 CST3 http://www.ncbi.nlm.nih.gov/gene/?term=1471 "ARMD11, HEL-S-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003740 1471 CST3 http://www.ncbi.nlm.nih.gov/gene/?term=1471 "ARMD11, HEL-S-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003741 147339 C18orf25 http://www.ncbi.nlm.nih.gov/gene/?term=147339 "ARKL1, RNF111L1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003742 147339 C18orf25 http://www.ncbi.nlm.nih.gov/gene/?term=147339 "ARKL1, RNF111L1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003743 14735 Gpc4 http://www.ncbi.nlm.nih.gov/gene/?term=14735 "9530073D23Rik, AF311610, AI385680, AI661372, K-glypican " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003744 147381 CBLN2 http://www.ncbi.nlm.nih.gov/gene/?term=147381 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003745 14745 Lpar1 http://www.ncbi.nlm.nih.gov/gene/?term=14745 "AI326300, Edg2, Gpcr26, Kdt2, lpA1, vzg-1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003746 147495 APCDD1 http://www.ncbi.nlm.nih.gov/gene/?term=147495 "B7323, DRAPC1, FP7019, HHS, HTS, HYPT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003747 1474 CST6 http://www.ncbi.nlm.nih.gov/gene/?term=1474 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003748 14751 Gpi1 http://www.ncbi.nlm.nih.gov/gene/?term=14751 "Amf, Gpi, Gpi-1, Gpi-1r, Gpi-1s, Gpi-1t-r, Gpi1-s, Gpi1-t, Gpi1s, MF, NK, NK/GPI, Nlk, Org, Pgi, Phi, Gpi1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003749 14756 Gpld1 http://www.ncbi.nlm.nih.gov/gene/?term=14756 "6330541J12Rik, AW546131 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003750 14758 Gpm6b http://www.ncbi.nlm.nih.gov/gene/?term=14758 "AI593561, Gpm6, M6B " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003751 147657 ZNF480 http://www.ncbi.nlm.nih.gov/gene/?term=147657 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003752 147660 ZNF578 http://www.ncbi.nlm.nih.gov/gene/?term=147660 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003753 147687 ZNF417 http://www.ncbi.nlm.nih.gov/gene/?term=147687 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003754 147687 ZNF417 http://www.ncbi.nlm.nih.gov/gene/?term=147687 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003755 147694 ZNF548 http://www.ncbi.nlm.nih.gov/gene/?term=147694 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003756 147694 ZNF548 http://www.ncbi.nlm.nih.gov/gene/?term=147694 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003757 1476 CSTB http://www.ncbi.nlm.nih.gov/gene/?term=1476 "CST6, EPM1, EPM1A, PME, STFB, ULD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003758 1476 CSTB http://www.ncbi.nlm.nih.gov/gene/?term=1476 "CST6, EPM1, EPM1A, PME, STFB, ULD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003759 1476 CSTB http://www.ncbi.nlm.nih.gov/gene/?term=1476 "CST6, EPM1, EPM1A, PME, STFB, ULD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003760 147727 ILF3-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=147727 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003761 14773 Grk5 http://www.ncbi.nlm.nih.gov/gene/?term=14773 Gprk5 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003762 1477 CSTF1 http://www.ncbi.nlm.nih.gov/gene/?term=1477 "CstF-50, CstFp50 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003763 1477 CSTF1 http://www.ncbi.nlm.nih.gov/gene/?term=1477 "CstF-50, CstFp50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003764 147841 SPC24 http://www.ncbi.nlm.nih.gov/gene/?term=147841 SPBC24 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003765 14789 P3h3 http://www.ncbi.nlm.nih.gov/gene/?term=14789 "BC016431, Grcb, Leprel2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003766 1478 CSTF2 http://www.ncbi.nlm.nih.gov/gene/?term=1478 CstF-64 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003767 1478 CSTF2 http://www.ncbi.nlm.nih.gov/gene/?term=1478 CstF-64 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003768 147920 IGFL2 http://www.ncbi.nlm.nih.gov/gene/?term=147920 "UNQ645, VPRI645 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003769 147920 IGFL2 http://www.ncbi.nlm.nih.gov/gene/?term=147920 "UNQ645, VPRI645 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003770 14794 Spsb2 http://www.ncbi.nlm.nih.gov/gene/?term=14794 "AI461677, C9, Grcc9, SSB2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003771 147965 FAM98C http://www.ncbi.nlm.nih.gov/gene/?term=147965 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003772 147968 CAPN12 http://www.ncbi.nlm.nih.gov/gene/?term=147968 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003773 14797 Aes http://www.ncbi.nlm.nih.gov/gene/?term=14797 "AL024115, Esp1, Grg, Grg-5, Grg5, Tle5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003774 1479 CSTF3 http://www.ncbi.nlm.nih.gov/gene/?term=1479 CSTF-77 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003775 14805 Grik1 http://www.ncbi.nlm.nih.gov/gene/?term=14805 "A830007B11Rik, D16Ium24, D16Ium24e, GluK1, GluK5, Glur-5, Glur5, Glurbeta1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003776 148103 ZNF599 http://www.ncbi.nlm.nih.gov/gene/?term=148103 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003777 14810 Grin1 http://www.ncbi.nlm.nih.gov/gene/?term=14810 "GluN1, GluRdelta1, GluRzeta1, M100174, NMD-R1, NMDAR1, NR1, Nmdar, Rgsc174 " mRNA Mus musculus 12853299 Endoplasmic reticulum Cortical neuron - "Subcellular fractionation studies show that all detectable NR1 mRNA is associated with rough endoplasmic reticulum, indicating that subcellular distribution of NR1 mRNA in fetal cortical neurons does not play a role in ethanol-mediated NR1 mRNA stabilization. " RLID00003778 148156 ZNF558 http://www.ncbi.nlm.nih.gov/gene/?term=148156 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003779 14815 Nr3c1 http://www.ncbi.nlm.nih.gov/gene/?term=14815 "GR, Grl-1, Grl1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003780 148170 CDC42EP5 http://www.ncbi.nlm.nih.gov/gene/?term=148170 "Borg3, CEP5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003781 148206 ZNF714 http://www.ncbi.nlm.nih.gov/gene/?term=148206 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003782 148206 ZNF714 http://www.ncbi.nlm.nih.gov/gene/?term=148206 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003783 148206 ZNF714 http://www.ncbi.nlm.nih.gov/gene/?term=148206 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003784 148213 ZNF681 http://www.ncbi.nlm.nih.gov/gene/?term=148213 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003785 148213 ZNF681 http://www.ncbi.nlm.nih.gov/gene/?term=148213 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003786 148223 C19orf25 http://www.ncbi.nlm.nih.gov/gene/?term=148223 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003787 148254 ZNF555 http://www.ncbi.nlm.nih.gov/gene/?term=148254 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003788 14825 Cxcl1 http://www.ncbi.nlm.nih.gov/gene/?term=14825 "Fsp, Gro1, KC, Mgsa, N51, Scyb1, gro " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003789 14825 Cxcl1 http://www.ncbi.nlm.nih.gov/gene/?term=14825 "Fsp, Gro1, KC, Mgsa, N51, Scyb1, gro " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003790 14827 Pdia3 http://www.ncbi.nlm.nih.gov/gene/?term=14827 "58kDa, ERp57, ERp60, ERp61, Erp, Grp58, PDI, PDI-Q2, PI-PLC, PLC[a], Plca " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003791 148281 SYT6 http://www.ncbi.nlm.nih.gov/gene/?term=148281 sytVI mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00003792 148281 SYT6 http://www.ncbi.nlm.nih.gov/gene/?term=148281 sytVI mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003793 14828 Hspa5 http://www.ncbi.nlm.nih.gov/gene/?term=14828 "AL022860, AU019543, Bip, D2Wsu141e, D2Wsu17e, Grp78, Hsce70, SEZ-7, Sez7, baffled, mBiP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003794 14828 Hspa5 http://www.ncbi.nlm.nih.gov/gene/?term=14828 "AL022860, AU019543, Bip, D2Wsu141e, D2Wsu17e, Grp78, Hsce70, SEZ-7, Sez7, baffled, mBiP " mRNA Mus musculus 12923260 Endoplasmic reticulum B cell S1 nuclease protection assays "Oligonucleotide probes were designed to hybridize with mRNAs encoding representative members of three classes of protein: soluble (GAPDH, Hsp90, and LDH), ER resident membrane (Sec61a and calnexin), and ER resident lumenal (BiP, calreticulin, and GRP94). " RLID00003795 14828 Hspa5 http://www.ncbi.nlm.nih.gov/gene/?term=14828 "AL022860, AU019543, Bip, D2Wsu141e, D2Wsu17e, Grp78, Hsce70, SEZ-7, Sez7, baffled, mBiP " mRNA Mus musculus 12923260 Ribosome B cell S1 nuclease protection assays "Using the procedures described above, the subcellular distribution of individual mRNAs in the cytosol and rough ER polysome fractions of Jurkat and J558 cells was determined. mRNAs for resident proteins of the ER lumen, including BiP, calreticulin, and GRP94, were also highly enriched on membrane-bound polysomes. " RLID00003796 14828 Hspa5 http://www.ncbi.nlm.nih.gov/gene/?term=14828 "Bip, Sez7, mBiP, Grp78, SEZ-7, Hsce70, baffled, AL022860, AU019543, D2Wsu17e, D2Wsu141e " mRNA Mus musculus 12923260 Ribosome J558 cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00003797 148413 LOC148413 http://www.ncbi.nlm.nih.gov/gene/?term=148413 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003798 14852 Gspt1 http://www.ncbi.nlm.nih.gov/gene/?term=14852 "AI314175, AI326449, AV307676, C79774, G1st, Gst-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003799 148534 TMEM56 http://www.ncbi.nlm.nih.gov/gene/?term=148534 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003800 14854 Gss http://www.ncbi.nlm.nih.gov/gene/?term=14854 "AI314904, GS-A/GS-B, GSH-S " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003801 14862 Gstm1 http://www.ncbi.nlm.nih.gov/gene/?term=14862 "Gstb-1, Gstb1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003802 1486 CTBS http://www.ncbi.nlm.nih.gov/gene/?term=1486 CTB mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003803 1486 CTBS http://www.ncbi.nlm.nih.gov/gene/?term=1486 CTB mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003804 1486 CTBS http://www.ncbi.nlm.nih.gov/gene/?term=1486 CTB mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003805 1487364 BICP0 http://www.ncbi.nlm.nih.gov/gene/?term=1487364 BoHV1_gp35 mRNA Bovine herpesvirus 1 25529439 Cytoplasm COS-7 cell qRT-PCR "We demonstrated interactions of VP8 with bICP0, gB, gC and gD mRNAs by RNA-immunoprecipitation and qPCR, both in the nucleus and cytoplasm of COS-7 cells. " RLID00003806 1487364 BICP0 http://www.ncbi.nlm.nih.gov/gene/?term=1487364 BoHV1_gp35 mRNA Bovine herpesvirus 1 25529439 Nucleus COS-7 cell qRT-PCR "We demonstrated interactions of VP8 with bICP0, gB, gC and gD mRNAs by RNA-immunoprecipitation and qPCR, both in the nucleus and cytoplasm of COS-7 cells. " RLID00003807 148738 HFE2 http://www.ncbi.nlm.nih.gov/gene/?term=148738 "HFE2A, HJV, JH, RGMC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003808 14873 Gsto1 http://www.ncbi.nlm.nih.gov/gene/?term=14873 "AA407097, AI194287, AU018802, Gsto-1, Gstx, Spg-r, p28 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003809 148789 B3GALNT2 http://www.ncbi.nlm.nih.gov/gene/?term=148789 "B3GalNAc-T2, MDDGA11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003810 1487 CTBP1 http://www.ncbi.nlm.nih.gov/gene/?term=1487 BARS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003811 1487 CTBP1 http://www.ncbi.nlm.nih.gov/gene/?term=1487 BARS mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003812 1487 CTBP1 http://www.ncbi.nlm.nih.gov/gene/?term=1487 BARS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003813 148808 MFSD4A http://www.ncbi.nlm.nih.gov/gene/?term=148808 "MFSD4, UNQ3064 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003814 148808 MFSD4A http://www.ncbi.nlm.nih.gov/gene/?term=148808 "MFSD4, UNQ3064 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003815 14884 Gtf2h1 http://www.ncbi.nlm.nih.gov/gene/?term=14884 "62kDa, AW743425, AW822074, BTF2 p62, C77871, p62 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003816 14885 Gtf2h4 http://www.ncbi.nlm.nih.gov/gene/?term=14885 "AW545633, BTF2 p52, p52 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003817 148867 SLC30A7 http://www.ncbi.nlm.nih.gov/gene/?term=148867 "ZNT7, ZnT-7, ZnTL2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003818 148867 SLC30A7 http://www.ncbi.nlm.nih.gov/gene/?term=148867 "ZNT7, ZnT-7, ZnTL2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003819 148867 SLC30A7 http://www.ncbi.nlm.nih.gov/gene/?term=148867 "ZNT7, ZnT-7, ZnTL2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003820 148867 SLC30A7 http://www.ncbi.nlm.nih.gov/gene/?term=148867 "ZNT7, ZnT-7, ZnTL2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003821 148898 ZNF436-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=148898 C1orf213 lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00003822 1488 CTBP2 http://www.ncbi.nlm.nih.gov/gene/?term=1488 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003823 148932 MOB3C http://www.ncbi.nlm.nih.gov/gene/?term=148932 "MOB1E, MOBKL2C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003824 148979 GLIS1 http://www.ncbi.nlm.nih.gov/gene/?term=148979 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003825 1489 CTF1 http://www.ncbi.nlm.nih.gov/gene/?term=1489 "CT-1, CT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003826 148 ADRA1A http://www.ncbi.nlm.nih.gov/gene/?term=148 "ADRA1C, ADRA1L1, ALPHA1AAR " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003827 148 ADRA1A http://www.ncbi.nlm.nih.gov/gene/?term=148 "ADRA1C, ADRA1L1, ALPHA1AAR " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003828 149041 RC3H1 http://www.ncbi.nlm.nih.gov/gene/?term=149041 "RNF198, ROQUIN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003829 149041 RC3H1 http://www.ncbi.nlm.nih.gov/gene/?term=149041 "RNF198, ROQUIN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003830 1490 CTGF http://www.ncbi.nlm.nih.gov/gene/?term=1490 "CCN2, HCS24, IGFBP8, NOV2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003831 14910 Gt(ROSA)26Sor http://www.ncbi.nlm.nih.gov/gene/?term=14910 "AV258896, Gtrgeo26, Gtrosa26, R26, ROSA26, Thumpd3as1 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003832 14913 Guca1a http://www.ncbi.nlm.nih.gov/gene/?term=14913 "GC-A, Gcap1, Guca1, mGCAP1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003833 149175 MANEAL http://www.ncbi.nlm.nih.gov/gene/?term=149175 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003834 149175 MANEAL http://www.ncbi.nlm.nih.gov/gene/?term=149175 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003835 149175 MANEAL http://www.ncbi.nlm.nih.gov/gene/?term=149175 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003836 149175 MANEAL http://www.ncbi.nlm.nih.gov/gene/?term=149175 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003837 1491 CTH http://www.ncbi.nlm.nih.gov/gene/?term=1491 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003838 14924 Magi1 http://www.ncbi.nlm.nih.gov/gene/?term=14924 "AIP3, BAP1, Baiap1, Gukmi1, MAGI1c, Magi-1, TNRC19, WWP3, mKIAA4129 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003839 149345 SHISA4 http://www.ncbi.nlm.nih.gov/gene/?term=149345 "C1orf40, TMEM58 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003840 14936 Gys1 http://www.ncbi.nlm.nih.gov/gene/?term=14936 "Gys3, MGS " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003841 149371 EXOC8 http://www.ncbi.nlm.nih.gov/gene/?term=149371 "EXO84, Exo84p, SEC84 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003842 149371 EXOC8 http://www.ncbi.nlm.nih.gov/gene/?term=149371 "EXO84, Exo84p, SEC84 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003843 149428 BNIPL http://www.ncbi.nlm.nih.gov/gene/?term=149428 "BNIP-S-1, BNIPL-2, BNIPL1, BNIPL2, BNIPS, PP753, BNIPL " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003844 149428 BNIPL http://www.ncbi.nlm.nih.gov/gene/?term=149428 "BNIP-S-1, BNIPL-2, BNIPL1, BNIPL2, BNIPS, PP753, BNIPL " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003845 149466 C1orf210 http://www.ncbi.nlm.nih.gov/gene/?term=149466 TEMP mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003846 149466 C1orf210 http://www.ncbi.nlm.nih.gov/gene/?term=149466 TEMP mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003847 14955 H19 http://www.ncbi.nlm.nih.gov/gene/?term=14955 AI747191 lncRNA Mus musculus 16874305 Cytoplasm Fibroblast qRT-PCR|Northern blot "The imprinted H19 ncRNA shows a mean nuclear/cytoplasmic ratio of 1.0:1, confirming a previous report that it is exported to the cytoplasm (Brannan et al, 1990) (Figure 6A). " RLID00003848 14955 H19 http://www.ncbi.nlm.nih.gov/gene/?term=14955 AI747191 lncRNA Mus musculus 25332394 Cytoplasm - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/H19/ RLID00003849 14955 H19 http://www.ncbi.nlm.nih.gov/gene/?term=14955 AI747191 lncRNA Mus musculus 17948025 Cytoplasm Fibroblast In situ hybridization|qRT-PCR "We sought to determine the subcellular localization of the non-coding H19 ICR transcripts. We separated nuclear and cytoplasmic RNA fractions from mouse embryonic fibroblasts. Igf2 and H19 gene transcripts were found both in the nucleus and in the cytoplasm, whereas the ncICR transcripts were almost exclusively detected in the nuclear fraction (Fig 1D), which is consistent with a function in gene expression. " RLID00003850 14955 H19 http://www.ncbi.nlm.nih.gov/gene/?term=14955 AI747191 lncRNA Mus musculus 22684254 Cytoplasm Embryonic Fibroblast qRT-PCR|Northern blot "The H19 locus expresses high levels of a 2.5 kb RNA Polymerase II dependent transcript, which is spliced, capped, polyadenylated, and exported into the cytoplasm. " RLID00003851 14955 H19 http://www.ncbi.nlm.nih.gov/gene/?term=14955 AI747191 lncRNA Mus musculus 17948025 Nucleus Fibroblast In situ hybridization|qRT-PCR "We sought to determine the subcellular localization of the non-coding H19 ICR transcripts. We separated nuclear and cytoplasmic RNA fractions from mouse embryonic fibroblasts. Igf2 and H19 gene transcripts were found both in the nucleus and in the cytoplasm, whereas the ncICR transcripts were almost exclusively detected in the nuclear fraction (Fig 1D), which is consistent with a function in gene expression. " RLID00003852 14955 H19 http://www.ncbi.nlm.nih.gov/gene/?term=14955 AI747191 lncRNA Mus musculus 10875929 Lamellipodium NIH 3T3 cell In situ hybridization "The results show that the distribution of full-length H19 RNA is similar to that of IMP-1 (21) by being either evenly distributed in areas with confluent growth-arrested cells (88% of transfected cells) or, as illustrated in Fig.8 B, localized to the leading edge of lamellipodia and perinuclear regions in dispersed proliferating cells (42% of transfected cells). " RLID00003853 14955 H19 http://www.ncbi.nlm.nih.gov/gene/?term=14955 AI747191 lncRNA Mus musculus 10875929 Cell leading edge NIH 3T3 cell In situ hybridization "The results show that the distribution of full-length H19 RNA is similar to that of IMP-1 (21) by being either evenly distributed in areas with confluent growth-arrested cells (88% of transfected cells) or, as illustrated in Fig.8 B, localized to the leading edge of lamellipodia and perinuclear regions in dispersed proliferating cells (42% of transfected cells). " RLID00003854 14955 H19 http://www.ncbi.nlm.nih.gov/gene/?term=14955 AI747191 lncRNA Mus musculus 10875929 Perinuclear NIH 3T3 cell In situ hybridization "The results show that the distribution of full-length H19 RNA is similar to that of IMP-1 (21) by being either evenly distributed in areas with confluent growth-arrested cells (88% of transfected cells) or, as illustrated in Fig.8 B, localized to the leading edge of lamellipodia and perinuclear regions in dispersed proliferating cells (42% of transfected cells). " RLID00003855 14955 H19 http://www.ncbi.nlm.nih.gov/gene/?term=14955 AI747191 lncRNA Mus musculus 15094229 Cytoplasm Hepatocyte In situ hybridization "Similar to albumin mRNA, H19 mRNA appeared to be localized mainly in the cytoplasm. " RLID00003856 149563 C1orf64 http://www.ncbi.nlm.nih.gov/gene/?term=149563 ERRF mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003857 1495 CTNNA1 http://www.ncbi.nlm.nih.gov/gene/?term=1495 "CAP102, MDPT2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003858 1495 CTNNA1 http://www.ncbi.nlm.nih.gov/gene/?term=1495 "CAP102, MDPT2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003859 1495 CTNNA1 http://www.ncbi.nlm.nih.gov/gene/?term=1495 CAP102 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003860 149603 RNF187 http://www.ncbi.nlm.nih.gov/gene/?term=149603 "RACO-1, RACO1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003861 149603 RNF187 http://www.ncbi.nlm.nih.gov/gene/?term=149603 "RACO-1, RACO1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003862 1497 CTNS http://www.ncbi.nlm.nih.gov/gene/?term=1497 "CTNS-LSB, PQLC4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003863 149840 C20orf196 http://www.ncbi.nlm.nih.gov/gene/?term=149840 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003864 149951 COMMD7 http://www.ncbi.nlm.nih.gov/gene/?term=149951 "C20orf92, dJ1085F17.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003865 149986 LSM14B http://www.ncbi.nlm.nih.gov/gene/?term=149986 "C20orf40, FAM61B, FT005, LSM13, RAP55B, bA11M20.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003866 1499 CTNNB1 http://www.ncbi.nlm.nih.gov/gene/?term=1499 "CTNNB, MRD19, armadillo " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003867 1499 CTNNB1 http://www.ncbi.nlm.nih.gov/gene/?term=1499 "CTNNB, MRD19, armadillo " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00003868 1499 CTNNB1 http://www.ncbi.nlm.nih.gov/gene/?term=1499 "CTNNB, MRD19, armadillo " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003869 1499 CTNNB1 http://www.ncbi.nlm.nih.gov/gene/?term=1499 "CTNNB, MRD19, armadillo " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003870 1499 CTNNB1 http://www.ncbi.nlm.nih.gov/gene/?term=1499 "CTNNB, MRD19, armadillo " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00003871 14 AAMP http://www.ncbi.nlm.nih.gov/gene/?term=14 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003872 14 AAMP http://www.ncbi.nlm.nih.gov/gene/?term=14 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003873 14 AAMP http://www.ncbi.nlm.nih.gov/gene/?term=14 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003874 150094 SIK1 http://www.ncbi.nlm.nih.gov/gene/?term=150094 "EIEE30, MSK, SIK, SNF1LK " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003875 1500 CTNND1 http://www.ncbi.nlm.nih.gov/gene/?term=1500 "CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN) " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003876 1500 CTNND1 http://www.ncbi.nlm.nih.gov/gene/?term=1500 "CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN) " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003877 1501 CTNND2 http://www.ncbi.nlm.nih.gov/gene/?term=1501 "GT24, NPRAP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003878 150223 YDJC http://www.ncbi.nlm.nih.gov/gene/?term=150223 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003879 150223 YDJC http://www.ncbi.nlm.nih.gov/gene/?term=150223 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003880 150274 HSCB http://www.ncbi.nlm.nih.gov/gene/?term=150274 "DNAJC20, HSC20, JAC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003881 150275 CCDC117 http://www.ncbi.nlm.nih.gov/gene/?term=150275 dJ366L4.1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003882 150275 CCDC117 http://www.ncbi.nlm.nih.gov/gene/?term=150275 dJ366L4.1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003883 150275 CCDC117 http://www.ncbi.nlm.nih.gov/gene/?term=150275 dJ366L4.1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003884 150356 CHADL http://www.ncbi.nlm.nih.gov/gene/?term=150356 SLRR4B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003885 150383 CDPF1 http://www.ncbi.nlm.nih.gov/gene/?term=150383 C22orf40 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003886 150383 CDPF1 http://www.ncbi.nlm.nih.gov/gene/?term=150383 C22orf40 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003887 1503 CTPS1 http://www.ncbi.nlm.nih.gov/gene/?term=1503 "CTPS, IMD24 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003888 150465 TTL http://www.ncbi.nlm.nih.gov/gene/?term=150465 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003889 15064 Mr1 http://www.ncbi.nlm.nih.gov/gene/?term=15064 H2ls mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003890 150678 MYEOV2 http://www.ncbi.nlm.nih.gov/gene/?term=150678 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003891 150684 COMMD1 http://www.ncbi.nlm.nih.gov/gene/?term=150684 "C2orf5, MURR1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003892 150684 COMMD1 http://www.ncbi.nlm.nih.gov/gene/?term=150684 "C2orf5, MURR1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003893 150684 COMMD1 http://www.ncbi.nlm.nih.gov/gene/?term=150684 "C2orf5, MURR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003894 150696 PROM2 http://www.ncbi.nlm.nih.gov/gene/?term=150696 PROML2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003895 150696 PROM2 http://www.ncbi.nlm.nih.gov/gene/?term=150696 PROML2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003896 150696 PROM2 http://www.ncbi.nlm.nih.gov/gene/?term=150696 PROML2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003897 150763 GPAT2 http://www.ncbi.nlm.nih.gov/gene/?term=150763 CT123 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003898 150771 ITPRIPL1 http://www.ncbi.nlm.nih.gov/gene/?term=150771 KIAA1754L mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003899 15078 H3f3a http://www.ncbi.nlm.nih.gov/gene/?term=15078 H3.3A mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003900 15081 H3f3b http://www.ncbi.nlm.nih.gov/gene/?term=15081 "9430068D06Rik, H3.3B " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003901 150864 FAM117B http://www.ncbi.nlm.nih.gov/gene/?term=150864 ALS2CR13 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003902 150864 FAM117B http://www.ncbi.nlm.nih.gov/gene/?term=150864 ALS2CR13 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003903 1508 CTSB http://www.ncbi.nlm.nih.gov/gene/?term=1508 "APPS, CPSB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003904 1508 CTSB http://www.ncbi.nlm.nih.gov/gene/?term=1508 "APPS, CPSB " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003905 1508 CTSB http://www.ncbi.nlm.nih.gov/gene/?term=1508 "APPS, CPSB " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003906 1508 CTSB http://www.ncbi.nlm.nih.gov/gene/?term=1508 "APPS, CPSB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003907 150946 GAREM2 http://www.ncbi.nlm.nih.gov/gene/?term=150946 "FAM59B, GAREML " mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00003908 150946 GAREM2 http://www.ncbi.nlm.nih.gov/gene/?term=150946 "FAM59B, GAREML " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003909 1509 CTSD http://www.ncbi.nlm.nih.gov/gene/?term=1509 "CLN10, CPSD, HEL-S-130P " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003910 1509 CTSD http://www.ncbi.nlm.nih.gov/gene/?term=1509 "CLN10, CPSD, HEL-S-130P " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003911 1509 CTSD http://www.ncbi.nlm.nih.gov/gene/?term=1509 "CLN10, CPSD, HEL-S-130P " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003912 151011 SEPT10 http://www.ncbi.nlm.nih.gov/gene/?term=151011 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003913 151050 KANSL1L http://www.ncbi.nlm.nih.gov/gene/?term=151050 "C2orf67, MSL1v2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003914 15108 Hsd17b10 http://www.ncbi.nlm.nih.gov/gene/?term=15108 "17bHSD10, Ads9, ERAB, Hadh2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003915 1510 CTSE http://www.ncbi.nlm.nih.gov/gene/?term=1510 CATE mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003916 15115 Hars http://www.ncbi.nlm.nih.gov/gene/?term=15115 MMHRS mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003917 151176 FAM132B http://www.ncbi.nlm.nih.gov/gene/?term=151176 "C1QTNF15, CTRP15 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003918 15117 Has2 http://www.ncbi.nlm.nih.gov/gene/?term=15117 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003919 151188 ARL6IP6 http://www.ncbi.nlm.nih.gov/gene/?term=151188 "AIP-6, AIP6, PFAAP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003920 151188 ARL6IP6 http://www.ncbi.nlm.nih.gov/gene/?term=151188 "AIP-6, AIP6, PFAAP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003921 151194 METTL21A http://www.ncbi.nlm.nih.gov/gene/?term=151194 "FAM119A, HCA557b, HSPA-KMT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003922 151195 CCNYL1 http://www.ncbi.nlm.nih.gov/gene/?term=151195 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003923 151230 KLHL23 http://www.ncbi.nlm.nih.gov/gene/?term=151230 DITHP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003924 151230 KLHL23 http://www.ncbi.nlm.nih.gov/gene/?term=151230 DITHP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003925 1512 CTSH http://www.ncbi.nlm.nih.gov/gene/?term=1512 "ACC-4, ACC-5, ACC4, ACC5, CPSB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003926 1512 CTSH http://www.ncbi.nlm.nih.gov/gene/?term=1512 "ACC-4, ACC-5, ACC4, ACC5, CPSB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003927 151354 FAM84A http://www.ncbi.nlm.nih.gov/gene/?term=151354 "NSE1, PP11517 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003928 151393 RMDN2 http://www.ncbi.nlm.nih.gov/gene/?term=151393 "BLOCK18, FAM82A, FAM82A1, PRO34163, PYST9371, RMD-2, RMD2, RMD4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003929 1514 CTSL http://www.ncbi.nlm.nih.gov/gene/?term=1514 "CATL1, MEP, CTSL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003930 1514 CTSL http://www.ncbi.nlm.nih.gov/gene/?term=1514 "CATL, CTSL1, MEP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003931 151516 ASPRV1 http://www.ncbi.nlm.nih.gov/gene/?term=151516 "MUNO, SASP, SASPase, Taps " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003932 151531 UPP2 http://www.ncbi.nlm.nih.gov/gene/?term=151531 "UDRPASE2, UP2, UPASE2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003933 15159 Hccs http://www.ncbi.nlm.nih.gov/gene/?term=15159 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003934 151613 TTC14 http://www.ncbi.nlm.nih.gov/gene/?term=151613 "DRDL5813, PRO19630 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003935 151636 DTX3L http://www.ncbi.nlm.nih.gov/gene/?term=151636 BBAP mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003936 151636 DTX3L http://www.ncbi.nlm.nih.gov/gene/?term=151636 BBAP mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003937 151636 DTX3L http://www.ncbi.nlm.nih.gov/gene/?term=151636 BBAP mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003938 151636 DTX3L http://www.ncbi.nlm.nih.gov/gene/?term=151636 BBAP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003939 15182 Hdac2 http://www.ncbi.nlm.nih.gov/gene/?term=15182 "D10Wsu179e, YAF1, Yy1bp, mRPD3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003940 15183 Hdac3 http://www.ncbi.nlm.nih.gov/gene/?term=15183 AW537363 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003941 151887 CCDC80 http://www.ncbi.nlm.nih.gov/gene/?term=151887 "DRO1, SSG1, URB, okuribin " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003942 151903 CCDC12 http://www.ncbi.nlm.nih.gov/gene/?term=151903 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003943 151903 CCDC12 http://www.ncbi.nlm.nih.gov/gene/?term=151903 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003944 151987 PPP4R2 http://www.ncbi.nlm.nih.gov/gene/?term=151987 PP4R2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003945 15199 Hebp1 http://www.ncbi.nlm.nih.gov/gene/?term=15199 "Hebp, p22HBP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003946 1519 CTSO http://www.ncbi.nlm.nih.gov/gene/?term=1519 CTSO1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003947 151 ADRA2B http://www.ncbi.nlm.nih.gov/gene/?term=151 "ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, FAME2, alpha-2BAR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003948 152002 XXYLT1 http://www.ncbi.nlm.nih.gov/gene/?term=152002 C3orf21 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003949 152006 RNF38 http://www.ncbi.nlm.nih.gov/gene/?term=152006 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003950 152007 GLIPR2 http://www.ncbi.nlm.nih.gov/gene/?term=152007 "C9orf19, GAPR-1, GAPR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003951 152007 GLIPR2 http://www.ncbi.nlm.nih.gov/gene/?term=152007 "C9orf19, GAPR-1, GAPR1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003952 15201 Hells http://www.ncbi.nlm.nih.gov/gene/?term=15201 "AI323785, E130115I21Rik, LSH, Lysh, PASG, YFK8 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003953 15201 Hells http://www.ncbi.nlm.nih.gov/gene/?term=15201 "AI323785, E130115I21Rik, LSH, Lysh, PASG, YFK8 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003954 1520 CTSS http://www.ncbi.nlm.nih.gov/gene/?term=1520 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003955 1520 CTSS http://www.ncbi.nlm.nih.gov/gene/?term=1520 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003956 1520 CTSS http://www.ncbi.nlm.nih.gov/gene/?term=1520 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003957 152100 CMC1 http://www.ncbi.nlm.nih.gov/gene/?term=152100 C3orf68 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003958 15212 Hexb http://www.ncbi.nlm.nih.gov/gene/?term=15212 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00003959 152137 CCDC50 http://www.ncbi.nlm.nih.gov/gene/?term=152137 "C3orf6, DFNA44, YMER " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003960 152137 CCDC50 http://www.ncbi.nlm.nih.gov/gene/?term=152137 "C3orf6, DFNA44, YMER " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003961 152137 CCDC50 http://www.ncbi.nlm.nih.gov/gene/?term=152137 "C3orf6, DFNA44, YMER " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003962 152137 CCDC50 http://www.ncbi.nlm.nih.gov/gene/?term=152137 "C3orf6, DFNA44, YMER " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00003963 152137 CCDC50 http://www.ncbi.nlm.nih.gov/gene/?term=152137 "C3orf6, DFNA44, YMER " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003964 152195 NUDT16P1 http://www.ncbi.nlm.nih.gov/gene/?term=152195 NUDT16P lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003965 15220 Foxq1 http://www.ncbi.nlm.nih.gov/gene/?term=15220 "HFH-1, Hfh1, Hfh1l, sa " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003966 152217 NCBP2-AS2 http://www.ncbi.nlm.nih.gov/gene/?term=152217 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003967 152273 FGD5 http://www.ncbi.nlm.nih.gov/gene/?term=152273 ZFYVE23 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003968 1522 CTSZ http://www.ncbi.nlm.nih.gov/gene/?term=1522 CTSX mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003969 1522 CTSZ http://www.ncbi.nlm.nih.gov/gene/?term=1522 CTSX mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003970 1522 CTSZ http://www.ncbi.nlm.nih.gov/gene/?term=1522 CTSX mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003971 15235 Mst1 http://www.ncbi.nlm.nih.gov/gene/?term=15235 "D3F15S2h, D9H3F15S2, DNF15S2h, Hgfl " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003972 1523 CUX1 http://www.ncbi.nlm.nih.gov/gene/?term=1523 "CASP, CDP, CDP/Cut, CDP1, COY1, CUTL1, CUX, Clox, Cux/CDP, GOLIM6, Nbla10317, p100, p110, p200, p75 " mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00003973 1523 CUX1 http://www.ncbi.nlm.nih.gov/gene/?term=1523 "CASP, CDP, CDP/Cut, CDP1, COY1, CUTL1, CUX, Clox, Cux/CDP, GOLIM6, Nbla10317, p100, p110, p200, p75 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003974 15247 Mfsd14a http://www.ncbi.nlm.nih.gov/gene/?term=15247 Hiat1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003975 152519 NIPAL1 http://www.ncbi.nlm.nih.gov/gene/?term=152519 NPAL1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003976 15251 Hif1a http://www.ncbi.nlm.nih.gov/gene/?term=15251 "AA959795, HIF-1-alpha, HIF1-alpha, HIF1alpha, MOP1, bHLHe78 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003977 15251 Hif1a http://www.ncbi.nlm.nih.gov/gene/?term=15251 "AA959795, HIF-1-alpha, HIF1-alpha, HIF1alpha, MOP1, bHLHe78 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003978 152559 PAQR3 http://www.ncbi.nlm.nih.gov/gene/?term=152559 RKTG mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003979 152579 SCFD2 http://www.ncbi.nlm.nih.gov/gene/?term=152579 STXBP1L1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003980 15257 Hipk1 http://www.ncbi.nlm.nih.gov/gene/?term=15257 "1110062K04Rik, Myak " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003981 15257 Hipk1 http://www.ncbi.nlm.nih.gov/gene/?term=15257 "1110062K04Rik, Myak " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003982 15259 Hipk3 http://www.ncbi.nlm.nih.gov/gene/?term=15259 "DYRK6, FIST3, PKY, mir-1902 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003983 15259 Hipk3 http://www.ncbi.nlm.nih.gov/gene/?term=15259 "DYRK6, FIST3, PKY, mir-1902 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003984 1525 CXADR http://www.ncbi.nlm.nih.gov/gene/?term=1525 "CAR, CAR4/6, HCAR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003985 1525 CXADR http://www.ncbi.nlm.nih.gov/gene/?term=1525 "CAR, CAR4/6, HCAR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003986 15277 Hk2 http://www.ncbi.nlm.nih.gov/gene/?term=15277 "AI642394, HKII " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003987 152815 THAP6 http://www.ncbi.nlm.nih.gov/gene/?term=152815 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003988 152831 KLB http://www.ncbi.nlm.nih.gov/gene/?term=152831 BKL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003989 15284 Hlx http://www.ncbi.nlm.nih.gov/gene/?term=15284 Hlx1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00003990 15289 Hmgb1 http://www.ncbi.nlm.nih.gov/gene/?term=15289 "HMG-1, Hmg1, SBP-1, p30 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00003991 15289 Hmgb1 http://www.ncbi.nlm.nih.gov/gene/?term=15289 "HMG-1, Hmg1, SBP-1, p30 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00003992 1528 CYB5A http://www.ncbi.nlm.nih.gov/gene/?term=1528 "CYB5, MCB5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003993 1528 CYB5A http://www.ncbi.nlm.nih.gov/gene/?term=1528 "CYB5, MCB5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00003994 1528 CYB5A http://www.ncbi.nlm.nih.gov/gene/?term=1528 "CYB5, MCB5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003995 152926 PPM1K http://www.ncbi.nlm.nih.gov/gene/?term=152926 "BDP, MSUDMV, PP2Ckappa, PP2Cm, PTMP, UG0882E07 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003996 152992 TRMT44 http://www.ncbi.nlm.nih.gov/gene/?term=152992 "C4orf23, METTL19, TRM44 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00003997 152 ADRA2C http://www.ncbi.nlm.nih.gov/gene/?term=152 "ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003998 153090 DAB2IP http://www.ncbi.nlm.nih.gov/gene/?term=153090 "AF9Q34, AIP-1, AIP1, DIP1/2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00003999 153090 DAB2IP http://www.ncbi.nlm.nih.gov/gene/?term=153090 "AF9Q34, AIP-1, AIP1, DIP1/2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004000 153129 SLC38A9 http://www.ncbi.nlm.nih.gov/gene/?term=153129 URLC11 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004001 15312 Hmgn1 http://www.ncbi.nlm.nih.gov/gene/?term=15312 "HMG-14, Hmg14 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004002 153201 SLC36A2 http://www.ncbi.nlm.nih.gov/gene/?term=153201 "PAT2, TRAMD1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004003 153201 SLC36A2 http://www.ncbi.nlm.nih.gov/gene/?term=153201 "PAT2, TRAMD1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004004 153222 CREBRF http://www.ncbi.nlm.nih.gov/gene/?term=153222 "C5orf41, LRF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004005 153241 CEP120 http://www.ncbi.nlm.nih.gov/gene/?term=153241 "CCDC100, SRTD13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004006 15331 Hmgn2 http://www.ncbi.nlm.nih.gov/gene/?term=15331 "HMG-17, Hmg17 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004007 153328 SLC25A48 http://www.ncbi.nlm.nih.gov/gene/?term=153328 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004008 153339 TMEM167A http://www.ncbi.nlm.nih.gov/gene/?term=153339 TMEM167 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004009 153443 SRFBP1 http://www.ncbi.nlm.nih.gov/gene/?term=153443 "BUD22, P49, Rlb1, STRAP, p49/STRAP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004010 153443 SRFBP1 http://www.ncbi.nlm.nih.gov/gene/?term=153443 "BUD22, P49, Rlb1, STRAP, p49/STRAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004011 1534 CYB561 http://www.ncbi.nlm.nih.gov/gene/?term=1534 "CYB561A1, FRRS2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004012 1534 CYB561 http://www.ncbi.nlm.nih.gov/gene/?term=1534 "CYB561A1, FRRS2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004013 153527 ZMAT2 http://www.ncbi.nlm.nih.gov/gene/?term=153527 "Ptg-12, Snu23 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004014 153562 MARVELD2 http://www.ncbi.nlm.nih.gov/gene/?term=153562 "DFNB49, MARVD2, MRVLDC2, Tric " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004015 153562 MARVELD2 http://www.ncbi.nlm.nih.gov/gene/?term=153562 "DFNB49, MARVD2, MRVLDC2, Tric " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004016 153562 MARVELD2 http://www.ncbi.nlm.nih.gov/gene/?term=153562 "DFNB49, MARVD2, MRVLDC2, Tric " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004017 153579 BTNL9 http://www.ncbi.nlm.nih.gov/gene/?term=153579 "BTN3, BTN8, VDLS1900 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004018 15357 Hmgcr http://www.ncbi.nlm.nih.gov/gene/?term=15357 "HMG-CoAR, Red " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004019 1535 CYBA http://www.ncbi.nlm.nih.gov/gene/?term=1535 p22-PHOX mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004020 1535 CYBA http://www.ncbi.nlm.nih.gov/gene/?term=1535 p22-PHOX mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004021 153642 ARSK http://www.ncbi.nlm.nih.gov/gene/?term=153642 TSULF mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004022 15369 Hmox2 http://www.ncbi.nlm.nih.gov/gene/?term=15369 "HO-2, HO2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004023 1536 CYBB http://www.ncbi.nlm.nih.gov/gene/?term=1536 "AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, IMD34, NOX2, p91-PHOX " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004024 15372 Hmx2 http://www.ncbi.nlm.nih.gov/gene/?term=15372 "Nkx-5.2, Nkx5-2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004025 153768 PRELID2 http://www.ncbi.nlm.nih.gov/gene/?term=153768 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004026 1537 CYC1 http://www.ncbi.nlm.nih.gov/gene/?term=1537 "MC3DN6, UQCR4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004027 1537 CYC1 http://www.ncbi.nlm.nih.gov/gene/?term=1537 "MC3DN6, UQCR4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004028 15382 Hnrnpa1 http://www.ncbi.nlm.nih.gov/gene/?term=15382 "HDP-1, Hdp, Hnrpa1, hnRNP A1, hnrnp-A1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004029 153830 RNF145 http://www.ncbi.nlm.nih.gov/gene/?term=153830 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004030 15384 Hnrnpab http://www.ncbi.nlm.nih.gov/gene/?term=15384 "3010025C11Rik, CBF-A, Cgbfa, Hnrpab " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004031 15384 Hnrnpab http://www.ncbi.nlm.nih.gov/gene/?term=15384 "3010025C11Rik, CBF-A, Cgbfa, Hnrpab " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004032 15387 Hnrnpk http://www.ncbi.nlm.nih.gov/gene/?term=15387 "Hnrpk, KBBP, NOVA " mRNA Mus musculus 25301173 Dendrite Hippocampus In situ hybridization "Figure 2: In situ hybridization reveals species-specific patterns of localization in neuronal dendrites. Fluorescent Microscopy evaluation of biotin-conjugated oligoprobes on paraformaldehyde fixed 14-day cultured rat and mouse cortical neurons hybridized with nine biotin-conjugated oligoprobes detected with streptadivin-Alexa Fluor 568 (Invitrogen). For each probe images set, the small bottom left corner panels represent MAP2 immuno-staining. Scale bar = 20um. (A), Probes against SFRS16, ARHGDIA and HNRPK transcripts show higher dendritic localization in mouse neurons than in rat neurons (Red box). (B), Probes against ZFP410, COMMD3 and RSP6 transcripts show higher dendritic localization in rat neurons than in mouse neurons (Blue box). (C), Probes against UBA52, OLFM1 and H2AFZ transcripts show high dendritic localization in both rat and mouse neurons (Black box). Data are collected from Figure 2. " RLID00004033 15397 Hoxa11os http://www.ncbi.nlm.nih.gov/gene/?term=15397 "Hoxa11as, Hoxa11s " lncRNA Mus musculus 23898399 Nucleus 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00004034 15397 Hoxa11os http://www.ncbi.nlm.nih.gov/gene/15397 "Hoxa11s, Hoxa11as " lncRNA Mus musculus 23898399 Nucleus 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00004035 15397 Hoxa11os http://www.ncbi.nlm.nih.gov/gene/15397 "Hoxa11s, Hoxa11as " lncRNA Mus musculus 23898399 Cytoplasm 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00004036 153 ADRB1 http://www.ncbi.nlm.nih.gov/gene/?term=153 "ADRB1R, B1AR, BETA1AR, RHR " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004037 153 ADRB1 http://www.ncbi.nlm.nih.gov/gene/?term=153 "ADRB1R, B1AR, BETA1AR, RHR " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004038 154007 SNRNP48 http://www.ncbi.nlm.nih.gov/gene/?term=154007 "C6orf151, dJ336K20B.1, dJ512B11.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004039 154007 SNRNP48 http://www.ncbi.nlm.nih.gov/gene/?term=154007 "C6orf151, dJ336K20B.1, dJ512B11.2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004040 154007 SNRNP48 http://www.ncbi.nlm.nih.gov/gene/?term=154007 "C6orf151, dJ336K20B.1, dJ512B11.2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004041 15401 Hoxa4 http://www.ncbi.nlm.nih.gov/gene/?term=15401 "AV206827, Hox-1.4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004042 154091 SLC2A12 http://www.ncbi.nlm.nih.gov/gene/?term=154091 "GLUT12, GLUT8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004043 1540 CYLD http://www.ncbi.nlm.nih.gov/gene/?term=1540 "BRSS, CDMT1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2, CYLD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004044 1540 CYLD http://www.ncbi.nlm.nih.gov/gene/?term=1540 "BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004045 154141 MBOAT1 http://www.ncbi.nlm.nih.gov/gene/?term=154141 "LPEAT1, LPLAT, LPLAT 1, LPSAT, OACT1, dJ434O11.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004046 154141 MBOAT1 http://www.ncbi.nlm.nih.gov/gene/?term=154141 "LPEAT1, LPLAT, LPLAT 1, LPSAT, OACT1, dJ434O11.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004047 154141 MBOAT1 http://www.ncbi.nlm.nih.gov/gene/?term=154141 "LPEAT1, LPLAT, LPLAT 1, LPSAT, OACT1, dJ434O11.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004048 154214 RNF217 http://www.ncbi.nlm.nih.gov/gene/?term=154214 "C6orf172, IBRDC1, dJ84N20.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004049 15423 Hoxc4 http://www.ncbi.nlm.nih.gov/gene/?term=15423 Hox-3.5 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004050 154313 CFAP206 http://www.ncbi.nlm.nih.gov/gene/?term=154313 "C6orf165, dJ382I10.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004051 154313 CFAP206 http://www.ncbi.nlm.nih.gov/gene/?term=154313 "C6orf165, dJ382I10.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004052 15444 Hpca http://www.ncbi.nlm.nih.gov/gene/?term=15444 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004053 154467 CCDC167 http://www.ncbi.nlm.nih.gov/gene/?term=154467 "C6orf129, HSPC265 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004054 1544 CYP1A2 http://www.ncbi.nlm.nih.gov/gene/?term=1544 "CP12, P3-450, P450(PA) " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004055 1544 CYP1A2 http://www.ncbi.nlm.nih.gov/gene/?term=1544 "CP12, P3-450, P450(PA) " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004056 15461 Hras http://www.ncbi.nlm.nih.gov/gene/?term=15461 "H-ras, Ha-ras, Harvey-ras-1, Hras1, Kras2, c-H-ras, c-Ha-ras, c-rasHa, ras, Hras " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004057 15463 Agfg1 http://www.ncbi.nlm.nih.gov/gene/?term=15463 "AU045498, C130049H11Rik, C85612, D730048C23Rik, Hrb, RAB, Rip " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004058 154664 ABCA13 http://www.ncbi.nlm.nih.gov/gene/?term=154664 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004059 154664 ABCA13 http://www.ncbi.nlm.nih.gov/gene/?term=154664 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004060 154664 ABCA13 http://www.ncbi.nlm.nih.gov/gene/?term=154664 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004061 154743 BMT2 http://www.ncbi.nlm.nih.gov/gene/?term=154743 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004062 154791 C7orf55 http://www.ncbi.nlm.nih.gov/gene/?term=154791 "FMC1, HSPC268 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004063 154807 VKORC1L1 http://www.ncbi.nlm.nih.gov/gene/?term=154807 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004064 15481 Hspa8 http://www.ncbi.nlm.nih.gov/gene/?term=15481 "2410008N15Rik, Hsc70, Hsc71, Hsc73, Hsp73, Hspa10 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004065 15483 Hsd11b1 http://www.ncbi.nlm.nih.gov/gene/?term=15483 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004066 15486 Hsd17b2 http://www.ncbi.nlm.nih.gov/gene/?term=15486 "AI194836, AI194967, AI255511 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004067 1548 CYP2A6 http://www.ncbi.nlm.nih.gov/gene/?term=1548 "CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004068 15490 Hsd17b7 http://www.ncbi.nlm.nih.gov/gene/?term=15490 "AI266814, ERG27 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004069 154 ADRB2 http://www.ncbi.nlm.nih.gov/gene/?term=154 "ADRB2R, ADRBR, B2AR, BAR, BETA2AR " mRNA Homo sapiens 23351737 Cytoplasm Smooth muscle cell Fluorescence in situ hybridization Fluorescent in situ hybridization (FISH) analysis to localize endogenous mRNA in DDT1-MF2 cells showed that β2-AR mRNA is localized to the peripheral cytoplasmic regions of DDT1-MF2 cells. The results of immunofluorescence staining and FISH analysis in control and HuR knockdown cells emphasize the spatiotemporal relationship between β2-AR mRNA localization and translation and its importance in receptor localization to the plasma membrane. RLID00004070 154 ADRB2 http://www.ncbi.nlm.nih.gov/gene/?term=154 "ADRB2R, ADRBR, B2AR, BAR, BETA2AR " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004071 15500 Hsf2 http://www.ncbi.nlm.nih.gov/gene/?term=15500 AI661205 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004072 15505 Hsph1 http://www.ncbi.nlm.nih.gov/gene/?term=15505 "105kDa, AI790491, Hsp105, Hsp110, hsp-E7I, hsp110/105 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004073 155060 LOC155060 http://www.ncbi.nlm.nih.gov/gene/?term=155060 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004074 155066 ATP6V0E2 http://www.ncbi.nlm.nih.gov/gene/?term=155066 "ATP6V0E2L, C7orf32 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004075 15516 Hsp90ab1 http://www.ncbi.nlm.nih.gov/gene/?term=15516 "90kDa, AL022974, C81438, Hsp84, Hsp84-1, Hsp90, Hspcb " mRNA Mus musculus 12923260 Ribosome J558 cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00004076 15519 Hsp90aa1 http://www.ncbi.nlm.nih.gov/gene/?term=15519 "86kDa, 89kDa, AL024080, AL024147, Hsp86-1, Hsp89, Hsp90, Hspca, hsp4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004077 15519 Hsp90aa1 http://www.ncbi.nlm.nih.gov/gene/?term=15519 "86kDa, 89kDa, AL024080, AL024147, Hsp86-1, Hsp89, Hsp90, Hspca, hsp4 " mRNA Mus musculus 12923260 Ribosome J558 cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00004078 15525 Hspa4 http://www.ncbi.nlm.nih.gov/gene/?term=15525 "70kDa, AI317151, APG-2, Hsp110, Hsp70RY, mKIAA4025 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004079 15526 Hspa9 http://www.ncbi.nlm.nih.gov/gene/?term=15526 "74kDa, Csa, Grp75, Hsc74, Hsp74, Hsp74aa, Mortalin, Mot-2, Mot2, Mthsp70, Pbp74, Hspa9 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004080 15530 Hspg2 http://www.ncbi.nlm.nih.gov/gene/?term=15530 "AI852380, Pcn, Plc, per " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004081 15530 Hspg2 http://www.ncbi.nlm.nih.gov/gene/?term=15530 "AI852380, Pcn, Plc, per " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004082 155370 SBDSP1 http://www.ncbi.nlm.nih.gov/gene/?term=155370 SBDSP lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004083 155400 NSUN5P1 http://www.ncbi.nlm.nih.gov/gene/?term=155400 "NSUN5B, WBSCR20B " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004084 155435 RBM33 http://www.ncbi.nlm.nih.gov/gene/?term=155435 PRR8 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004085 155435 RBM33 http://www.ncbi.nlm.nih.gov/gene/?term=155435 PRR8 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004086 15551 Htr1b http://www.ncbi.nlm.nih.gov/gene/?term=15551 mRNA Mus musculus 8159291 Cell body Pyramidal cell In situ hybridization "In the hippocampus, 5-hydroxytryptamine1B messenger RNA is localized in the cell bodies of pyramidal cells of the CA1 field. " RLID00004087 1555 CYP2B6 http://www.ncbi.nlm.nih.gov/gene/?term=1555 "CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004088 1555 CYP2B6 http://www.ncbi.nlm.nih.gov/gene/?term=1555 "CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004089 1555 CYP2B6 http://www.ncbi.nlm.nih.gov/gene/?term=1555 "CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004090 1555 CYP2B6 http://www.ncbi.nlm.nih.gov/gene/1555 "CPB6, EFVM, IIB1, P450, CYP2B, CYP2B7, CYP2B7P, CYPIIB6 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00004091 15566 Htr7 http://www.ncbi.nlm.nih.gov/gene/?term=15566 5-HT7 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004092 15568 Elavl1 http://www.ncbi.nlm.nih.gov/gene/?term=15568 "2410055N02Rik, HUR, Hua, W91709 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004093 15571 Elavl3 http://www.ncbi.nlm.nih.gov/gene/?term=15571 "2600009P04Rik, Huc, PLE21, mHuC " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004094 15572 Elavl4 http://www.ncbi.nlm.nih.gov/gene/?term=15572 "Elav, Hud, PNEM " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004095 15574 Hus1 http://www.ncbi.nlm.nih.gov/gene/?term=15574 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004096 155971 env http://www.ncbi.nlm.nih.gov/gene/?term=155971 HIV1gp8 mRNA Human immunodeficiency virus 1 9811683 Nucleus HeLa cell Confocal microscopy Subsequent optical Z sectioning by confocal microscopy confirmed that the signal for unspliced env mRNA was detectable throughout the nucleus in the presence of Rev (data not shown). RLID00004097 155971 env http://www.ncbi.nlm.nih.gov/gene/?term=155971 HIV1gp8 mRNA Human immunodeficiency virus 1 9811683 Cytoplasm HeLa cell S1 protection experiments "The HeLa CMV*Rev/pgEnv Hygro cells were grown in the presence or absence of tetracycline and subsequently fractionated into matrix, nucleoplasmic, and cytoplasmic fractions. S1 protection of the env unspliced RNA from each of these fractions revealed that the RNA was indeed associated with the nuclear matrix in both the absence (Fig.3A) and presence (Fig.3B) of Rev. " RLID00004098 155971 env http://www.ncbi.nlm.nih.gov/gene/?term=155971 HIV1gp8 mRNA Human immunodeficiency virus 1 9811683 Nucleoplasm HeLa cell S1 protection experiments "The HeLa CMV*Rev/pgEnv Hygro cells were grown in the presence or absence of tetracycline and subsequently fractionated into matrix, nucleoplasmic, and cytoplasmic fractions. S1 protection of the env unspliced RNA from each of these fractions revealed that the RNA was indeed associated with the nuclear matrix in both the absence (Fig.3A) and presence (Fig.3B) of Rev. " RLID00004099 155971 env http://www.ncbi.nlm.nih.gov/gene/?term=155971 HIV1gp8 mRNA Human immunodeficiency virus 1 9811683 Nucleus HeLa cell S1 protection experiments "The HeLa CMV*Rev/pgEnv Hygro cells were grown in the presence or absence of tetracycline and subsequently fractionated into matrix, nucleoplasmic, and cytoplasmic fractions. S1 protection of the env unspliced RNA from each of these fractions revealed that the RNA was indeed associated with the nuclear matrix in both the absence (Fig.3A) and presence (Fig.3B) of Rev. " RLID00004100 155971 env http://www.ncbi.nlm.nih.gov/gene/?term=155971 HIV1gp8 mRNA Human immunodeficiency virus 1 9811683 Nucleoplasm HeLa cell In situ hybridization "Using in situ hybridization, we demonstrated that in the absence of Rev, unspliced RNA generated with an HIV-1 env expression construct displayed discrete localization in the nucleus, coincident with the location of the gene and not associated with SC35-containing nuclear speckles. Expression of Rev resulted in a disperse signal for the unspliced RNA throughout both the nucleus and the cytoplasm. Subsequent fractionation of the nucleus revealed that the majority of unspliced viral RNA within the nucleus is associated with the nuclear matrix and that upon expression of Rev, a small proportion of the unspliced RNA is found within the nucleoplasm. " RLID00004101 155971 env http://www.ncbi.nlm.nih.gov/gene/?term=155971 HIV1gp8 mRNA Human immunodeficiency virus 1 9811683 Cytoplasm HeLa cell In situ hybridization "In contrast, upon induction of Rev expression, we detected unspliced and spliced RNA in the nucleoplasm and in the cytoplasm, consistent with the export of unspliced RNA (Fig. (Fig.3B).3B). " RLID00004102 155971 env http://www.ncbi.nlm.nih.gov/gene/?term=155971 HIV1gp8 mRNA Human immunodeficiency virus 1 9811683 Nucleus HeLa cell In situ hybridization Hybridization to unspliced HIV-1 env mRNA (pseudocolored in green) in the absence of Rev expression revealed that the unspliced RNA was located in the nucleus as a discrete signal (Fig. (Fig.1A).1A). RLID00004103 155971 env http://www.ncbi.nlm.nih.gov/gene/?term=155971 HIV1gp8 mRNA Human immunodeficiency virus 1 9811683 Nucleus HeLa cell In situ hybridization "Using in situ hybridization, we demonstrated that in the absence of Rev, unspliced RNA generated with an HIV-1 env expression construct displayed discrete localization in the nucleus, coincident with the location of the gene and not associated with SC35-containing nuclear speckles. Expression of Rev resulted in a disperse signal for the unspliced RNA throughout both the nucleus and the cytoplasm. Subsequent fractionation of the nucleus revealed that the majority of unspliced viral RNA within the nucleus is associated with the nuclear matrix and that upon expression of Rev, a small proportion of the unspliced RNA is found within the nucleoplasm. " RLID00004104 156 ADRBK1 http://www.ncbi.nlm.nih.gov/gene/?term=156 "BARK1, BETA-ARK1, GRK2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004105 156 ADRBK1 http://www.ncbi.nlm.nih.gov/gene/?term=156 "BARK1, BETA-ARK1, GRK2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004106 156 ADRBK1 http://www.ncbi.nlm.nih.gov/gene/?term=156 "BARK1, BETA-ARK1, GRK2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004107 157285 SGK223 http://www.ncbi.nlm.nih.gov/gene/?term=157285 PRAGMIN mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004108 157313 CDCA2 http://www.ncbi.nlm.nih.gov/gene/?term=157313 "PPP1R81, Repo-Man " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004109 157378 TMEM65 http://www.ncbi.nlm.nih.gov/gene/?term=157378 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004110 157506 RDH10 http://www.ncbi.nlm.nih.gov/gene/?term=157506 SDR16C4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004111 157506 RDH10 http://www.ncbi.nlm.nih.gov/gene/?term=157506 SDR16C4 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004112 157506 RDH10 http://www.ncbi.nlm.nih.gov/gene/?term=157506 SDR16C4 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004113 157506 RDH10 http://www.ncbi.nlm.nih.gov/gene/?term=157506 SDR16C4 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004114 157506 RDH10 http://www.ncbi.nlm.nih.gov/gene/?term=157506 SDR16C4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004115 157567 ANKRD46 http://www.ncbi.nlm.nih.gov/gene/?term=157567 "ANK-S, GENX-115279 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004116 157567 ANKRD46 http://www.ncbi.nlm.nih.gov/gene/?term=157567 "ANK-S, GENX-115279 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004117 157570 ESCO2 http://www.ncbi.nlm.nih.gov/gene/?term=157570 "2410004I17Rik, EFO2, RBS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004118 157638 FAM84B http://www.ncbi.nlm.nih.gov/gene/?term=157638 "BCMP101, NSE2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004119 157697 ERICH1 http://www.ncbi.nlm.nih.gov/gene/?term=157697 HSPC319 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004120 157697 ERICH1 http://www.ncbi.nlm.nih.gov/gene/?term=157697 HSPC319 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004121 157769 FAM91A1 http://www.ncbi.nlm.nih.gov/gene/?term=157769 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004122 1577 CYP3A5 http://www.ncbi.nlm.nih.gov/gene/?term=1577 "CP35, CYPIIIA5, P450PCN3, PCN3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004123 157807 CLVS1 http://www.ncbi.nlm.nih.gov/gene/?term=157807 "CRALBPL, RLBP1L1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004124 157922 CAMSAP1 http://www.ncbi.nlm.nih.gov/gene/?term=157922 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004125 157 ADRBK2 http://www.ncbi.nlm.nih.gov/gene/?term=157 "BARK2, GRK3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004126 157 ADRBK2 http://www.ncbi.nlm.nih.gov/gene/?term=157 "BARK2, GRK3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004127 158046 NXNL2 http://www.ncbi.nlm.nih.gov/gene/?term=158046 "C9orf121, RDCVF2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004128 158046 NXNL2 http://www.ncbi.nlm.nih.gov/gene/?term=158046 "C9orf121, RDCVF2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004129 158135 TTLL11 http://www.ncbi.nlm.nih.gov/gene/?term=158135 "C9orf20, bA244O19.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004130 158158 RASEF http://www.ncbi.nlm.nih.gov/gene/?term=158158 RAB45 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004131 158293 FAM120AOS http://www.ncbi.nlm.nih.gov/gene/?term=158293 C9orf10OS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004132 158293 FAM120AOS http://www.ncbi.nlm.nih.gov/gene/?term=158293 C9orf10OS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004133 158297 SAXO1 http://www.ncbi.nlm.nih.gov/gene/?term=158297 "C9orf138, FAM154A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004134 158381 ATP8B5P http://www.ncbi.nlm.nih.gov/gene/?term=158381 FetA lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004135 1584 CYP11B1 http://www.ncbi.nlm.nih.gov/gene/?term=1584 "CPN1, CYP11B, FHI, P450C11 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004136 158511 CSAG1 http://www.ncbi.nlm.nih.gov/gene/?term=158511 "CSAGE, CT24.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004137 158586 ZXDB http://www.ncbi.nlm.nih.gov/gene/?term=158586 "ZNF905, dJ83L6.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004138 158747 MOSPD2 http://www.ncbi.nlm.nih.gov/gene/?term=158747 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004139 158830 CXorf65 http://www.ncbi.nlm.nih.gov/gene/?term=158830 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004140 15893 Ica1 http://www.ncbi.nlm.nih.gov/gene/?term=15893 "69kDa, ICA69 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004141 1589 CYP21A2 http://www.ncbi.nlm.nih.gov/gene/?term=1589 "CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004142 158 ADSL http://www.ncbi.nlm.nih.gov/gene/?term=158 "AMPS, ASASE, ASL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004143 158 ADSL http://www.ncbi.nlm.nih.gov/gene/?term=158 "AMPS, ASASE, ASL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004144 158 ADSL http://www.ncbi.nlm.nih.gov/gene/?term=158 "AMPS, ASASE, ASL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004145 159090 FAM122B http://www.ncbi.nlm.nih.gov/gene/?term=159090 SPACIA2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004146 159091 FAM122C http://www.ncbi.nlm.nih.gov/gene/?term=159091 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004147 159195 USP54 http://www.ncbi.nlm.nih.gov/gene/?term=159195 "C10orf29, bA137L10.3, bA137L10.4 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004148 15925 Ide http://www.ncbi.nlm.nih.gov/gene/?term=15925 "1300012G03Rik, 4833415K22Rik, AA675336, AI507533 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004149 15926 Idh1 http://www.ncbi.nlm.nih.gov/gene/?term=15926 "AI314845, AI788952, E030024J03Rik, Id-1, Idh-1, Idpc " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004150 1592 CYP26A1 http://www.ncbi.nlm.nih.gov/gene/?term=1592 "CP26, CYP26, P450RAI, P450RAI1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004151 15944 Irgm1 http://www.ncbi.nlm.nih.gov/gene/?term=15944 "Ifggd3, Ifi1, Iigp3, Iipg3, Irgm, LRG-47 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004152 1595 CYP51A1 http://www.ncbi.nlm.nih.gov/gene/?term=1595 "CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004153 1595 CYP51A1 http://www.ncbi.nlm.nih.gov/gene/?term=1595 "CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004154 1595 CYP51A1 http://www.ncbi.nlm.nih.gov/gene/?term=1595 "CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004155 1595 CYP51A1 http://www.ncbi.nlm.nih.gov/gene/?term=1595 "CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004156 1595 CYP51A1 http://www.ncbi.nlm.nih.gov/gene/?term=1595 "CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004157 15979 Ifngr1 http://www.ncbi.nlm.nih.gov/gene/?term=15979 "CD119, IFN-gammaR, Ifgr, Ifngr, Nktar " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004158 159 ADSS http://www.ncbi.nlm.nih.gov/gene/?term=159 "ADEH 2, ADSS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004159 159 ADSS http://www.ncbi.nlm.nih.gov/gene/?term=159 "ADEH 2, ADSS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004160 159 ADSS http://www.ncbi.nlm.nih.gov/gene/?term=159 "ADEH, ADSS 2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004161 16000 Igf1 http://www.ncbi.nlm.nih.gov/gene/?term=16000 "C730016P09Rik, Igf-1, Igf-I " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004162 16002 Igf2 http://www.ncbi.nlm.nih.gov/gene/?term=16002 "AL033362, Igf-2, Igf-II, M6pr, Mpr, Peg2 " mRNA Mus musculus 17948025 Cytoplasm Fibroblast In situ hybridization|qRT-PCR "We sought to determine the subcellular localization of the non-coding H19 ICR transcripts. We separated nuclear and cytoplasmic RNA fractions from mouse embryonic fibroblasts. Igf2 and H19 gene transcripts were found both in the nucleus and in the cytoplasm, whereas the ncICR transcripts were almost exclusively detected in the nuclear fraction (Fig 1D), which is consistent with a function in gene expression. " RLID00004163 16002 Igf2 http://www.ncbi.nlm.nih.gov/gene/?term=16002 "AL033362, Igf-2, Igf-II, M6pr, Mpr, Peg2 " mRNA Mus musculus 17948025 Nucleus Fibroblast In situ hybridization|qRT-PCR "We sought to determine the subcellular localization of the non-coding H19 ICR transcripts. We separated nuclear and cytoplasmic RNA fractions from mouse embryonic fibroblasts. Igf2 and H19 gene transcripts were found both in the nucleus and in the cytoplasm, whereas the ncICR transcripts were almost exclusively detected in the nuclear fraction (Fig 1D), which is consistent with a function in gene expression. " RLID00004164 16004 Igf2r http://www.ncbi.nlm.nih.gov/gene/?term=16004 "AI661837, CD222, CI-MPR, M6P/IGF2R, Mpr300 " mRNA Mus musculus 16874305 Cytoplasm Fibroblast qRT-PCR|Northern blot "In contrast to Air, however, Igf2r mRNA is clearly exported to the cytoplasm (Figure 6B and C). " RLID00004165 16011 Igfbp5 http://www.ncbi.nlm.nih.gov/gene/?term=16011 "AI256729, AW208790, IGFBP-5, IGFBP-5P " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004166 16012 Igfbp6 http://www.ncbi.nlm.nih.gov/gene/?term=16012 IGFBP-6 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004167 1601 DAB2 http://www.ncbi.nlm.nih.gov/gene/?term=1601 "DOC-2, DOC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004168 160287 LDHAL6A http://www.ncbi.nlm.nih.gov/gene/?term=160287 LDH6A mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004169 160287 LDHAL6A http://www.ncbi.nlm.nih.gov/gene/?term=160287 LDH6A mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004170 1603 DAD1 http://www.ncbi.nlm.nih.gov/gene/?term=1603 OST2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004171 1603 DAD1 http://www.ncbi.nlm.nih.gov/gene/?term=1603 OST2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004172 160418 TMTC3 http://www.ncbi.nlm.nih.gov/gene/?term=160418 SMILE mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004173 160428 ALDH1L2 http://www.ncbi.nlm.nih.gov/gene/?term=160428 mtFDH mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004174 1604 CD55 http://www.ncbi.nlm.nih.gov/gene/?term=1604 "CR, CROM, DAF, TC " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004175 160518 DENND5B http://www.ncbi.nlm.nih.gov/gene/?term=160518 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004176 1605 DAG1 http://www.ncbi.nlm.nih.gov/gene/?term=1605 "156DAG, A3a, AGRNR, DAG, MDDGA9, MDDGC7, MDDGC9 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004177 1605 DAG1 http://www.ncbi.nlm.nih.gov/gene/?term=1605 "156DAG, A3a, AGRNR, DAG, MDDGA9, MDDGC7, MDDGC9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004178 16065 Igh-VS107 http://www.ncbi.nlm.nih.gov/gene/?term=16065 "IgG, IgH, VhNZA6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004179 16068 Il18bp http://www.ncbi.nlm.nih.gov/gene/?term=16068 "IL-18BP, Igifbp, MC54L " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004180 1606 DGKA http://www.ncbi.nlm.nih.gov/gene/?term=1606 "DAGK, DAGK1, DGK-alpha " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004181 160857 CCDC122 http://www.ncbi.nlm.nih.gov/gene/?term=160857 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004182 160857 CCDC122 http://www.ncbi.nlm.nih.gov/gene/?term=160857 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004183 1609 DGKQ http://www.ncbi.nlm.nih.gov/gene/?term=1609 "DAGK, DAGK4, DAGK7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004184 160 AP2A1 http://www.ncbi.nlm.nih.gov/gene/?term=160 "ADTAA, AP2-ALPHA, CLAPA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004185 1610 DAO http://www.ncbi.nlm.nih.gov/gene/?term=1610 "DAAO, DAMOX, OXDA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004186 1611 DAP http://www.ncbi.nlm.nih.gov/gene/?term=1611 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004187 1611 DAP http://www.ncbi.nlm.nih.gov/gene/?term=1611 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004188 161291 TMEM30B http://www.ncbi.nlm.nih.gov/gene/?term=161291 CDC50B mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004189 1612 DAPK1 http://www.ncbi.nlm.nih.gov/gene/?term=1612 DAPK mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004190 1612 DAPK1 http://www.ncbi.nlm.nih.gov/gene/?term=1612 DAPK mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004191 161357 MDGA2 http://www.ncbi.nlm.nih.gov/gene/?term=161357 "MAMDC1, c14_5286 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004192 1613 DAPK3 http://www.ncbi.nlm.nih.gov/gene/?term=1613 "DLK, ZIP, ZIPK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004193 161424 NOP9 http://www.ncbi.nlm.nih.gov/gene/?term=161424 C14orf21 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004194 161436 EML5 http://www.ncbi.nlm.nih.gov/gene/?term=161436 EMAP-2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004195 161436 EML5 http://www.ncbi.nlm.nih.gov/gene/?term=161436 EMAP-2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004196 161497 STRC http://www.ncbi.nlm.nih.gov/gene/?term=161497 DFNB16 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004197 16150 Ikbkb http://www.ncbi.nlm.nih.gov/gene/?term=16150 "AI132552, IKK-2, IKK-beta, IKK2, IKK[b], IKKbeta " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004198 16150 Ikbkb http://www.ncbi.nlm.nih.gov/gene/?term=16150 "AI132552, IKK-2, IKK-beta, IKK2, IKK[b], IKKbeta " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004199 1615 DARS http://www.ncbi.nlm.nih.gov/gene/?term=1615 "HBSL, aspRS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004200 1615 DARS http://www.ncbi.nlm.nih.gov/gene/?term=1615 "HBSL, aspRS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004201 1615 DARS http://www.ncbi.nlm.nih.gov/gene/?term=1615 "HBSL, aspRS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004202 16164 Il13ra1 http://www.ncbi.nlm.nih.gov/gene/?term=16164 "AI882074, CD213a1, IL-13R-alpha-1, IL-13r[a], Il13ra, NR4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004203 1616 DAXX http://www.ncbi.nlm.nih.gov/gene/?term=1616 "BING2, DAP6, EAP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004204 1616 DAXX http://www.ncbi.nlm.nih.gov/gene/?term=1616 "BING2, DAP6, EAP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004205 1616 DAXX http://www.ncbi.nlm.nih.gov/gene/?term=1616 "BING2, DAP6, EAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004206 161742 SPRED1 http://www.ncbi.nlm.nih.gov/gene/?term=161742 "NFLS, PPP1R147, hSpred1, spred-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004207 161742 SPRED1 http://www.ncbi.nlm.nih.gov/gene/?term=161742 "NFLS, PPP1R147, hSpred1, spred-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004208 16175 Il1a http://www.ncbi.nlm.nih.gov/gene/?term=16175 Il-1a mRNA Mus musculus 26179904 Cytosol Macrophage qRT-PCR "As expected, the mature IL-1a and Gapdh transcripts were localized to the cytosol, whereas 7SK RNA was confined to the nucleus. " RLID00004209 161829 EXD1 http://www.ncbi.nlm.nih.gov/gene/?term=161829 EXDL1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004210 161829 EXD1 http://www.ncbi.nlm.nih.gov/gene/?term=161829 EXDL1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004211 16182 Il18r1 http://www.ncbi.nlm.nih.gov/gene/?term=16182 "Il18ralpha, Il1rrp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004212 1618 DAZL http://www.ncbi.nlm.nih.gov/gene/?term=1618 "DAZH, DAZL1, DAZLA, SPGYLA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004213 16192 Il5ra http://www.ncbi.nlm.nih.gov/gene/?term=16192 "CD125, CDw125, Il5r " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004214 16195 Il6st http://www.ncbi.nlm.nih.gov/gene/?term=16195 "5133400A03Rik, AA389424, BB405851, CD130, D13Ertd699e, gp130 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004215 161 AP2A2 http://www.ncbi.nlm.nih.gov/gene/?term=161 "ADTAB, CLAPA2, HIP-9, HIP9, HYPJ " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004216 16201 Ilf3 http://www.ncbi.nlm.nih.gov/gene/?term=16201 "MBII-26, MPHOSPH4, NF90, NFAR " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004217 162073 ITPRIPL2 http://www.ncbi.nlm.nih.gov/gene/?term=162073 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004218 162073 ITPRIPL2 http://www.ncbi.nlm.nih.gov/gene/?term=162073 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004219 162073 ITPRIPL2 http://www.ncbi.nlm.nih.gov/gene/?term=162073 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004220 162073 ITPRIPL2 http://www.ncbi.nlm.nih.gov/gene/?term=162073 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004221 16210 Impact http://www.ncbi.nlm.nih.gov/gene/?term=16210 E430016J11Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004222 16211 Kpnb1 http://www.ncbi.nlm.nih.gov/gene/?term=16211 "AA409963, IPOB, Impnb " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004223 16211 Kpnb1 http://www.ncbi.nlm.nih.gov/gene/?term=16211 "AA409963, IPOB, Impnb " mRNA Mus musculus 22841314 Axon Sciatic nerves In situ hybridization Here we show that a long 3' untranslated region (3' UTR) directs axonal localization of Importin β1. RLID00004224 1622 DBI http://www.ncbi.nlm.nih.gov/gene/?term=1622 "ACBD1, ACBP, CCK-RP, EP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004225 162417 NAGS http://www.ncbi.nlm.nih.gov/gene/?term=162417 "AGAS, ARGA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004226 162427 FAM134C http://www.ncbi.nlm.nih.gov/gene/?term=162427 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004227 162427 FAM134C http://www.ncbi.nlm.nih.gov/gene/?term=162427 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004228 162427 FAM134C http://www.ncbi.nlm.nih.gov/gene/?term=162427 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004229 162427 FAM134C http://www.ncbi.nlm.nih.gov/gene/?term=162427 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004230 162605 KRT28 http://www.ncbi.nlm.nih.gov/gene/?term=162605 "K25IRS4, KRT25D " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004231 1627 DBN1 http://www.ncbi.nlm.nih.gov/gene/?term=1627 D0S117E mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004232 1628 DBP http://www.ncbi.nlm.nih.gov/gene/?term=1628 DABP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004233 1628 DBP http://www.ncbi.nlm.nih.gov/gene/?term=1628 DABP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004234 162966 ZNF600 http://www.ncbi.nlm.nih.gov/gene/?term=162966 KR-ZNF1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004235 162967 ZNF320 http://www.ncbi.nlm.nih.gov/gene/?term=162967 ZFPL mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004236 162967 ZNF320 http://www.ncbi.nlm.nih.gov/gene/?term=162967 ZFPL mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004237 162968 ZNF497 http://www.ncbi.nlm.nih.gov/gene/?term=162968 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004238 162968 ZNF497 http://www.ncbi.nlm.nih.gov/gene/?term=162968 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004239 162989 DEDD2 http://www.ncbi.nlm.nih.gov/gene/?term=162989 FLAME-3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004240 162998 OR7D2 http://www.ncbi.nlm.nih.gov/gene/?term=162998 "HTPCRH03, OR19-10, OR19-4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004241 162998 OR7D2 http://www.ncbi.nlm.nih.gov/gene/?term=162998 "HTPCRH03, OR19-10, OR19-4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004242 1629 DBT http://www.ncbi.nlm.nih.gov/gene/?term=1629 "BCATE2, BCKAD-E2, BCKADE2, BCOADC-E2, E2, E2B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004243 162 AP1B1 http://www.ncbi.nlm.nih.gov/gene/?term=162 "ADTB1, AP105A, BAM22, CLAPB2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004244 162 AP1B1 http://www.ncbi.nlm.nih.gov/gene/?term=162 "ADTB1, AP105A, BAM22, CLAPB2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004245 163033 ZNF579 http://www.ncbi.nlm.nih.gov/gene/?term=163033 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004246 163049 ZNF791 http://www.ncbi.nlm.nih.gov/gene/?term=163049 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004247 163051 ZNF709 http://www.ncbi.nlm.nih.gov/gene/?term=163051 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004248 163051 ZNF709 http://www.ncbi.nlm.nih.gov/gene/?term=163051 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004249 163126 EID2 http://www.ncbi.nlm.nih.gov/gene/?term=163126 "CRI2, EID-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004250 16319 Incenp http://www.ncbi.nlm.nih.gov/gene/?term=16319 "2700067E22Rik, AU019509, C130081E20, C77457 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004251 163227 ZNF100 http://www.ncbi.nlm.nih.gov/gene/?term=163227 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004252 163227 ZNF100 http://www.ncbi.nlm.nih.gov/gene/?term=163227 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004253 16329 Inpp1 http://www.ncbi.nlm.nih.gov/gene/?term=16329 "2300002C06Rik, AV137389 " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00004254 1632 ECI1 http://www.ncbi.nlm.nih.gov/gene/?term=1632 DCI mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004255 1632 ECI1 http://www.ncbi.nlm.nih.gov/gene/?term=1632 DCI mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004256 16333 Ins1 http://www.ncbi.nlm.nih.gov/gene/?term=16333 "Ins-1, Ins2-rs1 " mRNA Mus musculus 25018104 Endoplasmic reticulum INS-1 cell qRT-PCR "Preceding apoptosis, increasing ER stress agent levels progressively increases IRE1α phosphorylation, XBP1 mRNA splicing, endonucleolytic decay of the ER-localized mRNA, Ins1 mRNA (which encodes proinsulin), induction of thioredoxin-interacting protein (TXNIP) mRNA (whose product activates the NLRP3 inflammasome), and downstream c-Jun terminal kinase phosphorylation (JNKs) (Figure S1E,F). " RLID00004257 16333 Ins1 http://www.ncbi.nlm.nih.gov/gene/?term=16333 "Ins-1, Ins2-rs1 " mRNA Mus musculus 15972000 Endoplasmic reticulum MIN6 cell Northern blot "In conclusion, our results provide evidence that the selective recruitment of proinsulin mRNA to the ER, together with increases in the rate of initiation are important mediators of glucose-stimulated proinsulin synthesis in pancreatic beta-cells. " RLID00004258 16334 Ins2 http://www.ncbi.nlm.nih.gov/gene/?term=16334 "AA986540, Ins-2, InsII, Mody, Mody4 " mRNA Mus musculus 15972000 Endoplasmic reticulum MIN6 cell Northern blot "In conclusion, our results provide evidence that the selective recruitment of proinsulin mRNA to the ER, together with increases in the rate of initiation are important mediators of glucose-stimulated proinsulin synthesis in pancreatic beta-cells. " RLID00004259 16337 Insr http://www.ncbi.nlm.nih.gov/gene/?term=16337 "4932439J01Rik, CD220, D630014A15Rik, IR, IR-A, IR-B " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004260 1633 DCK http://www.ncbi.nlm.nih.gov/gene/?term=1633 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004261 16341 Eif3e http://www.ncbi.nlm.nih.gov/gene/?term=16341 "48kDa, Eif3s6, Int6, eIF3-p46, eIF3-p48 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004262 16341 Eif3e http://www.ncbi.nlm.nih.gov/gene/?term=16341 "48kDa, Eif3s6, Int6, eIF3-p46, eIF3-p48 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004263 163486 DENND1B http://www.ncbi.nlm.nih.gov/gene/?term=163486 "C1ORF18, C1orf218, FAM31B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004264 16351 Ipp http://www.ncbi.nlm.nih.gov/gene/?term=16351 "D4Jhu8, Mipp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004265 16353 Ipw http://www.ncbi.nlm.nih.gov/gene/?term=16353 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004266 163590 TOR1AIP2 http://www.ncbi.nlm.nih.gov/gene/?term=163590 "IFRG15, LULL1, NET9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004267 163590 TOR1AIP2 http://www.ncbi.nlm.nih.gov/gene/?term=163590 "IFRG15, LULL1, NET9 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004268 163590 TOR1AIP2 http://www.ncbi.nlm.nih.gov/gene/?term=163590 "IFRG15, LULL1, NET9 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004269 1635 DCTD http://www.ncbi.nlm.nih.gov/gene/?term=1635 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004270 1635 DCTD http://www.ncbi.nlm.nih.gov/gene/?term=1635 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004271 163702 IFNLR1 http://www.ncbi.nlm.nih.gov/gene/?term=163702 "CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004272 163702 IFNLR1 http://www.ncbi.nlm.nih.gov/gene/?term=163702 "CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004273 16372 Irx2 http://www.ncbi.nlm.nih.gov/gene/?term=16372 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004274 163732 CITED4 http://www.ncbi.nlm.nih.gov/gene/?term=163732 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004275 16373 Irx3 http://www.ncbi.nlm.nih.gov/gene/?term=16373 AI894186 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004276 163859 SDE2 http://www.ncbi.nlm.nih.gov/gene/?term=163859 "C1orf55, dJ671D7.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004277 163859 SDE2 http://www.ncbi.nlm.nih.gov/gene/?term=163859 "C1orf55, dJ671D7.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004278 163859 SDE2 http://www.ncbi.nlm.nih.gov/gene/?term=163859 "C1orf55, dJ671D7.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004279 163859 SDE2 http://www.ncbi.nlm.nih.gov/gene/?term=163859 "C1orf55, dJ671D7.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004280 163882 CNST http://www.ncbi.nlm.nih.gov/gene/?term=163882 "C1orf71, PPP1R64 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004281 16392 Isl1 http://www.ncbi.nlm.nih.gov/gene/?term=16392 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004282 1639 DCTN1 http://www.ncbi.nlm.nih.gov/gene/?term=1639 "DAP-150, DP-150, P135 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004283 163 AP2B1 http://www.ncbi.nlm.nih.gov/gene/?term=163 "ADTB2, AP105B, AP2-BETA, CLAPB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004284 163 AP2B1 http://www.ncbi.nlm.nih.gov/gene/?term=163 "ADTB2, AP105B, AP2-BETA, CLAPB1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004285 16401 Itga4 http://www.ncbi.nlm.nih.gov/gene/?term=16401 "CD49DB, Itga4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004286 16403 Itga6 http://www.ncbi.nlm.nih.gov/gene/?term=16403 "5033401O05Rik, AI115430, Cd49f, VLA-6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004287 16407 Itgae http://www.ncbi.nlm.nih.gov/gene/?term=16407 "A530055J10, CD103, aM290, alpha-E1, alpha-M290 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004288 164091 PAQR7 http://www.ncbi.nlm.nih.gov/gene/?term=164091 "MPRA, PGLP, mSR " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004289 164091 PAQR7 http://www.ncbi.nlm.nih.gov/gene/?term=164091 "MPRA, PGLP, mSR " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004290 16410 Itgav http://www.ncbi.nlm.nih.gov/gene/?term=16410 "1110004F14Rik, 2610028E01Rik, CD51, D430040G12Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004291 16410 Itgav http://www.ncbi.nlm.nih.gov/gene/?term=16410 "1110004F14Rik, 2610028E01Rik, CD51, D430040G12Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004292 16412 Itgb1 http://www.ncbi.nlm.nih.gov/gene/?term=16412 "4633401G24Rik, AA409975, AA960159, CD29, ENSMUSG00000051907, Fnrb, Gm9863, gpIIa " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004293 16412 Itgb1 http://www.ncbi.nlm.nih.gov/gene/?term=16412 "4633401G24Rik, AA409975, AA960159, CD29, ENSMUSG00000051907, Fnrb, Gm9863, gpIIa " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004294 16415 Itgb2l http://www.ncbi.nlm.nih.gov/gene/?term=16415 "5033406G21Rik, pactolus " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004295 1641 DCX http://www.ncbi.nlm.nih.gov/gene/?term=1641 "DBCN, DC, LISX, SCLH, XLIS " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004296 1641 DCX http://www.ncbi.nlm.nih.gov/gene/?term=1641 "DBCN, DC, LISX, SCLH, XLIS " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004297 16423 Cd47 http://www.ncbi.nlm.nih.gov/gene/?term=16423 "9130415E20Rik, AA407862, AI848868, AW108519, B430305P08Rik, IAP, Itgp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004298 16428 Itk http://www.ncbi.nlm.nih.gov/gene/?term=16428 "Emt, Tcsk, Tsk " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004299 1642 DDB1 http://www.ncbi.nlm.nih.gov/gene/?term=1642 "DDBA, UV-DDB1, XAP1, XPCE, XPE, XPE-BF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004300 1642 DDB1 http://www.ncbi.nlm.nih.gov/gene/?term=1642 "DDBA, UV-DDB1, XAP1, XPCE, XPE, XPE-BF " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004301 1642 DDB1 http://www.ncbi.nlm.nih.gov/gene/?term=1642 "DDBA, UV-DDB1, XAP1, XPCE, XPE, XPE-BF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004302 16430 Stt3a http://www.ncbi.nlm.nih.gov/gene/?term=16430 "AA408947, BB081708, Itm1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004303 16432 Itm2b http://www.ncbi.nlm.nih.gov/gene/?term=16432 "AI256040, Bri, Bri2, Bricd2b, D14Sel6, E25BMM, imBRI2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004304 16438 Itpr1 http://www.ncbi.nlm.nih.gov/gene/?term=16438 "D6Pas2, ENSMUSG00000072853, Gm10429, IP3R1, InsP3R, Ip3r, Itpr-1, P400, Pcp-1, Pcp1, opt, wblo " mRNA Mus musculus 25821909 Dendrite Neuron Fluorescence in situ hybridization "DISC1 colocalizes with HZF and ITPR1 mRNA in hippocampal dendrites and directly associates with neuronal mRNAs, including ITPR1 mRNA. DISC1 colocalized with HZF and Itpr1 mRNA in hippocampal dendrites. " RLID00004305 1643 DDB2 http://www.ncbi.nlm.nih.gov/gene/?term=1643 "DDBB, UV-DDB2, XPE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004306 1643 DDB2 http://www.ncbi.nlm.nih.gov/gene/?term=1643 "DDBB, UV-DDB2, XPE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004307 16443 Itsn1 http://www.ncbi.nlm.nih.gov/gene/?term=16443 "AA517634, AA545208, AI316805, AI839402, AI848451, Ehsh1, Ese1, Itsn, Sh3p17 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004308 16443 Itsn1 http://www.ncbi.nlm.nih.gov/gene/?term=16443 "AA517634, AA545208, AI316805, AI839402, AI848451, Ehsh1, Ese1, Itsn, Sh3p17 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004309 16447 Ivl http://www.ncbi.nlm.nih.gov/gene/?term=16447 1110019C06Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004310 16452 Jak2 http://www.ncbi.nlm.nih.gov/gene/?term=16452 Fd17 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004311 1645 AKR1C1 http://www.ncbi.nlm.nih.gov/gene/?term=1645 "2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004312 16467 Atcay http://www.ncbi.nlm.nih.gov/gene/?term=16467 "3322401A10Rik, BB077577, BNIP-H, CLAC, hes, ji " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004313 16476 Jun http://www.ncbi.nlm.nih.gov/gene/?term=16476 "AP-1c, c-jun, Jun " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004314 16478 Jund http://www.ncbi.nlm.nih.gov/gene/?term=16478 Jund1 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004315 1647 GADD45A http://www.ncbi.nlm.nih.gov/gene/?term=1647 "DDIT1, GADD45 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004316 16480 Jup http://www.ncbi.nlm.nih.gov/gene/?term=16480 "Ctnng, D930025P04Rik, PG " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004317 164832 LONRF2 http://www.ncbi.nlm.nih.gov/gene/?term=164832 RNF192 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004318 16485 Kcna1 http://www.ncbi.nlm.nih.gov/gene/?term=16485 "AI840627, Kca1-1, Kv1.1, MBK1, Mk-1, Shak, mceph " mRNA Mus musculus 21233214 Axon Neuron RT-PCR "Figure 3: Presynaptic localization of Kv1.1, -1.2, -.3, and -1.6 on dopamine axons of the dorsal striatum. Data are collected from Figure 3. " RLID00004319 16485 Kcna1 http://www.ncbi.nlm.nih.gov/gene/?term=16485 "AI840627, Kca1-1, Kv1.1, MBK1, Mk-1, Shak, mceph " mRNA Mus musculus 26512708 Axon ForeBrain Immunoprecipitation|RIP-Chip "HuD has also been implicated in axonal localization of other neuronal mRNAs including Tau, Neuritin/CPG15, Kv.1.1 and CaMKIIα mRNAs " RLID00004320 16490 Kcna2 http://www.ncbi.nlm.nih.gov/gene/?term=16490 "Akr6a4, ENSMUSG00000074335, Gm10672, Kca1-2, Kv1.2, Mk-2 " mRNA Mus musculus 21233214 Axon Neuron RT-PCR "Figure 3: Presynaptic localization of Kv1.1, -1.2, -.3, and -1.6 on dopamine axons of the dorsal striatum. Data are collected from Figure 3. " RLID00004321 16491 Kcna3 http://www.ncbi.nlm.nih.gov/gene/?term=16491 "Kca1-3, Kv1.3, Mk-3 " mRNA Mus musculus 21233214 Axon Neuron RT-PCR "Figure 3: Presynaptic localization of Kv1.1, -1.2, -.3, and -1.6 on dopamine axons of the dorsal striatum. Data are collected from Figure 3. " RLID00004322 16494 Kcna6 http://www.ncbi.nlm.nih.gov/gene/?term=16494 "Kv1.6, MK1.6 " mRNA Mus musculus 21233214 Axon Neuron RT-PCR "Figure 3: Presynaptic localization of Kv1.1, -1.2, -.3, and -1.6 on dopamine axons of the dorsal striatum. Data are collected from Figure 3. " RLID00004323 16497 Kcnab1 http://www.ncbi.nlm.nih.gov/gene/?term=16497 "Akr8a8, Kvbeta1.1, mKv(beta)1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004324 16498 Kcnab2 http://www.ncbi.nlm.nih.gov/gene/?term=16498 "F5, I2rf5, Kcnb3, kv-beta-2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004325 1649 DDIT3 http://www.ncbi.nlm.nih.gov/gene/?term=1649 "CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004326 1649 DDIT3 http://www.ncbi.nlm.nih.gov/gene/?term=1649 "CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004327 1649 DDIT3 http://www.ncbi.nlm.nih.gov/gene/?term=1649 "CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004328 1649 DDIT3 http://www.ncbi.nlm.nih.gov/gene/?term=1649 "CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004329 164 AP1G1 http://www.ncbi.nlm.nih.gov/gene/?term=164 "ADTG, CLAPG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004330 164 AP1G1 http://www.ncbi.nlm.nih.gov/gene/?term=164 "ADTG, CLAPG1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004331 164 AP1G1 http://www.ncbi.nlm.nih.gov/gene/?term=164 "ADTG, CLAPG1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004332 16500 Kcnb1 http://www.ncbi.nlm.nih.gov/gene/?term=16500 "Kcr1-1, Kv2.1, Shab " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004333 16508 Kcnd2 http://www.ncbi.nlm.nih.gov/gene/?term=16508 "AI839615, AW555701, Kv4.2, R75121, mKIAA1044 " mRNA Mus musculus 22099464 Dendrite Hippocampus Fluorescence in situ hybridization "Moreover, we found dendritic localization of Kv4.2 mRNA in the CA1 dendritic field of the hippocampus (Figure 1A). " RLID00004334 1650 DDOST http://www.ncbi.nlm.nih.gov/gene/?term=1650 "AGER1, CDG1R, OKSWcl45, OST, OST48, WBP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004335 1650 DDOST http://www.ncbi.nlm.nih.gov/gene/?term=1650 "AGER1, CDG1R, OKSWcl45, OST, OST48, WBP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004336 1650 DDOST http://www.ncbi.nlm.nih.gov/gene/?term=1650 "AGER1, CDG1R, OKSWcl45, OST, OST48, WBP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004337 16514 Kcnj11 http://www.ncbi.nlm.nih.gov/gene/?term=16514 "Kir6.2, mBIR " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004338 16516 Kcnj15 http://www.ncbi.nlm.nih.gov/gene/?term=16516 "4930414N08Rik, AI182284, AI267127, IRKK, Kir4.2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004339 1652 DDT http://www.ncbi.nlm.nih.gov/gene/?term=1652 DDCT mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004340 1652 DDT http://www.ncbi.nlm.nih.gov/gene/?term=1652 DDCT mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004341 1652 DDT http://www.ncbi.nlm.nih.gov/gene/?term=1652 DDCT mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004342 165324 UBXN2A http://www.ncbi.nlm.nih.gov/gene/?term=165324 UBXD4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004343 165324 UBXN2A http://www.ncbi.nlm.nih.gov/gene/?term=165324 UBXD4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004344 16536 Kcnq2 http://www.ncbi.nlm.nih.gov/gene/?term=16536 "HNSPC, KQT2, Nmf134 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004345 1653 DDX1 http://www.ncbi.nlm.nih.gov/gene/?term=1653 "DBP-RB, UKVH5d " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004346 1653 DDX1 http://www.ncbi.nlm.nih.gov/gene/?term=1653 "DBP-RB, UKVH5d " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004347 16543 Mdfic http://www.ncbi.nlm.nih.gov/gene/?term=16543 "Kdt1, Mdfid " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004348 16548 Khk http://www.ncbi.nlm.nih.gov/gene/?term=16548 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004349 1654 DDX3X http://www.ncbi.nlm.nih.gov/gene/?term=1654 "CAP-Rf, DBX, DDX14, DDX3, HLP2, MRX102 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004350 1654 DDX3X http://www.ncbi.nlm.nih.gov/gene/?term=1654 "CAP-Rf, DBX, DDX14, DDX3, HLP2, MRX102 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004351 1654 DDX3X http://www.ncbi.nlm.nih.gov/gene/?term=1654 "CAP-Rf, DBX, DDX14, DDX3, HLP2, MRX102 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004352 1655 DDX5 http://www.ncbi.nlm.nih.gov/gene/?term=1655 "G17P1, HLR1, HUMP68, p68 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004353 1655 DDX5 http://www.ncbi.nlm.nih.gov/gene/?term=1655 "G17P1, HLR1, HUMP68, p68 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004354 16561 Kif1b http://www.ncbi.nlm.nih.gov/gene/?term=16561 "A530096N05Rik, AI448212, AI506502, D4Mil1e, KIF1Bp130, KIF1Bp204 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004355 16563 Kif2a http://www.ncbi.nlm.nih.gov/gene/?term=16563 "C530030B14Rik, Kif2, Kns2, M-kinesin " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004356 16568 Kif3a http://www.ncbi.nlm.nih.gov/gene/?term=16568 "Kif3, Kifl, Kns3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004357 1656 DDX6 http://www.ncbi.nlm.nih.gov/gene/?term=1656 "HLR2, P54, RCK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004358 1656 DDX6 http://www.ncbi.nlm.nih.gov/gene/?term=1656 "HLR2, P54, RCK " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004359 1656 DDX6 http://www.ncbi.nlm.nih.gov/gene/?term=1656 "HLR2, P54, RCK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004360 16570 Kif3c http://www.ncbi.nlm.nih.gov/gene/?term=16570 mKIAA4058 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004361 16573 Kif5b http://www.ncbi.nlm.nih.gov/gene/?term=16573 "AL022807, Khc, Khcs, Kns1, Ukhc " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00004362 16574 Kif5c http://www.ncbi.nlm.nih.gov/gene/?term=16574 "KINN, Khc, NKHC, NKHC2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004363 16579 Kifap3 http://www.ncbi.nlm.nih.gov/gene/?term=16579 "KAP-3, KAP3, SMAP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004364 1657 DMXL1 http://www.ncbi.nlm.nih.gov/gene/?term=1657 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004365 1657 DMXL1 http://www.ncbi.nlm.nih.gov/gene/?term=1657 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004366 16588 Kin http://www.ncbi.nlm.nih.gov/gene/?term=16588 Kin17 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004367 16589 Uhmk1 http://www.ncbi.nlm.nih.gov/gene/?term=16589 "4732477C12Rik, 4930500M09Rik, AA673513, AI449218, AU021979, KIS, Kist, P-CIP2 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004368 165918 RNF168 http://www.ncbi.nlm.nih.gov/gene/?term=165918 hRNF168 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004369 16592 Fabp5 http://www.ncbi.nlm.nih.gov/gene/?term=16592 "E-FABP, Fabpe, Klbp, PA-FABP, mal1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004370 16594 Klc2 http://www.ncbi.nlm.nih.gov/gene/?term=16594 "8030455F02Rik, AW212649, KLC 2, KLC-2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004371 16598 Klf2 http://www.ncbi.nlm.nih.gov/gene/?term=16598 Lklf mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004372 16599 Klf3 http://www.ncbi.nlm.nih.gov/gene/?term=16599 "9930027G08Rik, AL024007, Bklf, Tef-2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004373 1659 DHX8 http://www.ncbi.nlm.nih.gov/gene/?term=1659 "DDX8, HRH1, PRP22, PRPF22 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004374 1659 DHX8 http://www.ncbi.nlm.nih.gov/gene/?term=1659 "DDX8, HRH1, PRP22, PRPF22 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004375 165 AEBP1 http://www.ncbi.nlm.nih.gov/gene/?term=165 ACLP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004376 16600 Klf4 http://www.ncbi.nlm.nih.gov/gene/?term=16600 "EZF, Gklf, Zie " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004377 166012 CHST13 http://www.ncbi.nlm.nih.gov/gene/?term=166012 C4ST3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004378 1660 DHX9 http://www.ncbi.nlm.nih.gov/gene/?term=1660 "DDX9, LKP, NDH2, NDHII, RHA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004379 1660 DHX9 http://www.ncbi.nlm.nih.gov/gene/?term=1660 "DDX9, LKP, NDH2, NDHII, RHA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004380 1660 DHX9 http://www.ncbi.nlm.nih.gov/gene/?term=1660 "DDX9, LKP, NDH2, NDHII, RHA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004381 16612 Klk1 http://www.ncbi.nlm.nih.gov/gene/?term=16612 "0610007D04Rik, KAL-B, Kalb6, Klk6, mGk-6, Klk1 " mRNA Mus musculus 2033241 Nucleus Submandibular gland Autoradiography Resolution obtained with this 3H-labeled probe showed mGK-6 mRNA in striated duct cells to be located on RER and in the nucleus and perinuclear area of the cell. RLID00004382 16612 Klk1 http://www.ncbi.nlm.nih.gov/gene/?term=16612 "0610007D04Rik, KAL-B, Kalb6, Klk6, mGk-6, Klk1 " mRNA Mus musculus 2033241 Perinuclear Submandibular gland Autoradiography Resolution obtained with this 3H-labeled probe showed mGK-6 mRNA in striated duct cells to be located on RER and in the nucleus and perinuclear area of the cell. RLID00004383 16612 Klk1 http://www.ncbi.nlm.nih.gov/gene/?term=16612 "0610007D04Rik, KAL-B, Kalb6, Klk6, mGk-6, Klk1 " mRNA Mus musculus 2033241 Endoplasmic reticulum Submandibular gland Autoradiography Resolution obtained with this 3H-labeled probe showed mGK-6 mRNA in striated duct cells to be located on RER and in the nucleus and perinuclear area of the cell. RLID00004384 16619 Klk1b27 http://www.ncbi.nlm.nih.gov/gene/?term=16619 "Gk27, Klk21l, Klk27, mGK-27 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004385 1662 DDX10 http://www.ncbi.nlm.nih.gov/gene/?term=1662 HRH-J8 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004386 1662 DDX10 http://www.ncbi.nlm.nih.gov/gene/?term=1662 HRH-J8 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004387 166336 PRICKLE2 http://www.ncbi.nlm.nih.gov/gene/?term=166336 EPM5 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004388 166378 SPATA5 http://www.ncbi.nlm.nih.gov/gene/?term=166378 "AFG2, EHLMRS, SPAF " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004389 166378 SPATA5 http://www.ncbi.nlm.nih.gov/gene/?term=166378 "AFG2, EHLMRS, SPAF " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004390 166379 BBS12 http://www.ncbi.nlm.nih.gov/gene/?term=166379 C4orf24 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004391 1663 DDX11 http://www.ncbi.nlm.nih.gov/gene/?term=1663 "CHL1, CHLR1, KRG2, WABS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004392 1663 DDX11 http://www.ncbi.nlm.nih.gov/gene/?term=1663 "CHL1, CHLR1, KRG2, WABS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004393 16643 Klrd1 http://www.ncbi.nlm.nih.gov/gene/?term=16643 CD94 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004394 16656 Hivep3 http://www.ncbi.nlm.nih.gov/gene/?term=16656 "2900056N03Rik, A130075N07, AI848000, E030045D18Rik, KBP-1, KBP1, Krc, Rc, Schnurri-3, Shn3, Zas3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004395 1665 DHX15 http://www.ncbi.nlm.nih.gov/gene/?term=1665 "DBP1, DDX15, HRH2, PRP43, PRPF43, PrPp43p " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004396 16661 Krt10 http://www.ncbi.nlm.nih.gov/gene/?term=16661 "D130054E02Rik, K10, K1C1, Krt-1.10, Krt1-10 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004397 16666 Krt16 http://www.ncbi.nlm.nih.gov/gene/?term=16666 "AI324768, CK-16, K16, Krt1-16 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004398 1666 DECR1 http://www.ncbi.nlm.nih.gov/gene/?term=1666 "DECR, NADPH, SDR18C1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004399 1666 DECR1 http://www.ncbi.nlm.nih.gov/gene/?term=1666 "DECR, NADPH, SDR18C1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004400 16670 Krt32 http://www.ncbi.nlm.nih.gov/gene/?term=16670 "Ha3, Hka2, K32, Krt1-2, Krtha2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004401 16675 Krt27 http://www.ncbi.nlm.nih.gov/gene/?term=16675 "CK-27, Krt1-c29, mIRSa3.1, stpm " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004402 166815 TIGD2 http://www.ncbi.nlm.nih.gov/gene/?term=166815 HEL106 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004403 166929 SGMS2 http://www.ncbi.nlm.nih.gov/gene/?term=166929 SMS2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004404 166968 MIER3 http://www.ncbi.nlm.nih.gov/gene/?term=166968 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004405 166 AES http://www.ncbi.nlm.nih.gov/gene/?term=166 "AES-1, AES-2, ESP1, GRG, GRG5, Grg-5, TLE5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004406 166 AES http://www.ncbi.nlm.nih.gov/gene/?term=166 "AES-1-2, ESP1, GRG, GRG5, Grg-5, TLE5, AES " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004407 16709 Ktn1 http://www.ncbi.nlm.nih.gov/gene/?term=16709 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004408 167153 PAPD4 http://www.ncbi.nlm.nih.gov/gene/?term=167153 "GLD2, TUT2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004409 167153 PAPD4 http://www.ncbi.nlm.nih.gov/gene/?term=167153 "GLD2, TUT2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004410 167153 PAPD4 http://www.ncbi.nlm.nih.gov/gene/?term=167153 "GLD2, TUT2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004411 167227 DCP2 http://www.ncbi.nlm.nih.gov/gene/?term=167227 NUDT20 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004412 167227 DCP2 http://www.ncbi.nlm.nih.gov/gene/?term=167227 NUDT20 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004413 167227 DCP2 http://www.ncbi.nlm.nih.gov/gene/?term=167227 NUDT20 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004414 16728 L1cam http://www.ncbi.nlm.nih.gov/gene/?term=16728 "CD171, L1, N-CAM-L1, NCAM-L1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004415 1672 DEFB1 http://www.ncbi.nlm.nih.gov/gene/?term=1672 "BD1, DEFB-1, DEFB101, HBD1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004416 1675 CFD http://www.ncbi.nlm.nih.gov/gene/?term=1675 "ADIPSIN, ADN, DF, PFD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004417 1675 CFD http://www.ncbi.nlm.nih.gov/gene/?term=1675 "ADIPSIN, ADN, DF, PFD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004418 16765 Stmn1 http://www.ncbi.nlm.nih.gov/gene/?term=16765 "19k, Lag, Lap18, Op18, P18, P19, Pig, Pp17, Pp18, Pp19, Pr22, Smn " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004419 167691 LCA5 http://www.ncbi.nlm.nih.gov/gene/?term=167691 C6orf152 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004420 1676 DFFA http://www.ncbi.nlm.nih.gov/gene/?term=1676 "DFF-45, DFF1, ICAD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004421 1676 DFFA http://www.ncbi.nlm.nih.gov/gene/?term=1676 "DFF-45, DFF1, ICAD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004422 1676 DFFA http://www.ncbi.nlm.nih.gov/gene/?term=1676 "DFF-45, DFF1, ICAD " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004423 1676 DFFA http://www.ncbi.nlm.nih.gov/gene/?term=1676 "DFF-45, DFF1, ICAD " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004424 16775 Lama4 http://www.ncbi.nlm.nih.gov/gene/?term=16775 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004425 1677 DFFB http://www.ncbi.nlm.nih.gov/gene/?term=1677 "CAD, CPAN, DFF-40, DFF2, DFF40 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004426 16780 Lamb3 http://www.ncbi.nlm.nih.gov/gene/?term=16780 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004427 16782 Lamc2 http://www.ncbi.nlm.nih.gov/gene/?term=16782 AA589349 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004428 16785 Rpsa http://www.ncbi.nlm.nih.gov/gene/?term=16785 "67kDa, 67lr, AL022858, Lamr, Lamr1, Lamrl1, MLR, P40, P40-3, P40-8 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004429 16785 Rpsa http://www.ncbi.nlm.nih.gov/gene/?term=16785 "67kDa, 67lr, AL022858, Lamr, Lamr1, Lamrl1, MLR, P40, P40-3, P40-8 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00004430 16792 Laptm5 http://www.ncbi.nlm.nih.gov/gene/?term=16792 E3 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004431 16795 Large http://www.ncbi.nlm.nih.gov/gene/?term=16795 "BPFD#36, Gyltl1a, Mbp-1, Mbp1, enr, fg, froggy, myd " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004432 16815 Lbx2 http://www.ncbi.nlm.nih.gov/gene/?term=16815 Lbx2h mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004433 16818 Lck http://www.ncbi.nlm.nih.gov/gene/?term=16818 "Hck-3, Lsk, Lskt, p56, p56Lck " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004434 16828 Ldha http://www.ncbi.nlm.nih.gov/gene/?term=16828 "Ldh1, Ldhm, l7R2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004435 16828 Ldha http://www.ncbi.nlm.nih.gov/gene/?term=16828 "Ldh1, Ldhm, l7R2 " mRNA Mus musculus 12923260 Ribosome B cell S1 nuclease protection assays "However, and as depicted in Figure 4 (Cytosol), mRNAs encoding GAPDH and LDH were present in both free and membrane-bound polysomes, and mRNAs encoding Hsp90 displayed a high enrichment in the membrane-bound fraction (75%-97%). Such partitioning of mRNAs to the ER was observed in 15 independent experiments using ER derived from Jurkat and J558 cells alike, thus confirming that mRNAs encoding signal-sequence-bearing proteins and mRNAs encoding cytosolic proteins are present on the ER. " RLID00004436 16828 Ldha http://www.ncbi.nlm.nih.gov/gene/?term=16828 "Ldh1, Ldhm, l7R2 " mRNA Mus musculus 12923260 Ribosome J558 cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00004437 16832 Ldhb http://www.ncbi.nlm.nih.gov/gene/?term=16832 "AI790582, H-Ldh, LDH-B, LDH-H, Ldh-2, Ldh2 " mRNA Mus musculus 12923260 Ribosome B cell S1 nuclease protection assays "However, and as depicted in Figure 4 (Cytosol), mRNAs encoding GAPDH and LDH were present in both free and membrane-bound polysomes, and mRNAs encoding Hsp90 displayed a high enrichment in the membrane-bound fraction (75%-97%). Such partitioning of mRNAs to the ER was observed in 15 independent experiments using ER derived from Jurkat and J558 cells alike, thus confirming that mRNAs encoding signal-sequence-bearing proteins and mRNAs encoding cytosolic proteins are present on the ER. " RLID00004438 16832 Ldhb http://www.ncbi.nlm.nih.gov/gene/?term=16832 "AI790582, H-Ldh, LDH-B, LDH-H, Ldh-2, Ldh2 " mRNA Mus musculus 12923260 Ribosome J558 cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00004439 16833 Ldhc http://www.ncbi.nlm.nih.gov/gene/?term=16833 "LDH-C4, Ldh-3, Ldh-x, Ldh34, Ldhc " mRNA Mus musculus 12923260 Ribosome B cell S1 nuclease protection assays "However, and as depicted in Figure 4 (Cytosol), mRNAs encoding GAPDH and LDH were present in both free and membrane-bound polysomes, and mRNAs encoding Hsp90 displayed a high enrichment in the membrane-bound fraction (75%-97%). Such partitioning of mRNAs to the ER was observed in 15 independent experiments using ER derived from Jurkat and J558 cells alike, thus confirming that mRNAs encoding signal-sequence-bearing proteins and mRNAs encoding cytosolic proteins are present on the ER. " RLID00004440 16833 Ldhc http://www.ncbi.nlm.nih.gov/gene/?term=16833 "LDH-C4, Ldh-3, Ldh-x, Ldh34, Ldhc " mRNA Mus musculus 12923260 Ribosome J558 cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00004441 16834 Cog1 http://www.ncbi.nlm.nih.gov/gene/?term=16834 "6030445I15, Ldlb, mKIAA1381 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004442 16835 Ldlr http://www.ncbi.nlm.nih.gov/gene/?term=16835 Hlb301 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004443 168374 ZNF92 http://www.ncbi.nlm.nih.gov/gene/?term=168374 "HEL-203, HPF12, HTF12, TF12 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004444 168374 ZNF92 http://www.ncbi.nlm.nih.gov/gene/?term=168374 "HEL-203, HPF12, HTF12, TF12 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004445 16842 Lef1 http://www.ncbi.nlm.nih.gov/gene/?term=16842 "3000002B05, AI451430, Lef-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004446 168451 THAP5 http://www.ncbi.nlm.nih.gov/gene/?term=168451 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004447 168451 THAP5 http://www.ncbi.nlm.nih.gov/gene/?term=168451 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004448 16846 Lep http://www.ncbi.nlm.nih.gov/gene/?term=16846 "ob, obese " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004449 168544 ZNF467 http://www.ncbi.nlm.nih.gov/gene/?term=168544 "EZI, Zfp467 " mRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00004450 16855 Lgals4 http://www.ncbi.nlm.nih.gov/gene/?term=16855 gal-4 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004451 16865 Eif2d http://www.ncbi.nlm.nih.gov/gene/?term=16865 "D1Ertd5e, Lgtn " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004452 16870 Lhx2 http://www.ncbi.nlm.nih.gov/gene/?term=16870 "LH2A, Lh-2, Lim2, ap, apterous " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004453 16874 Lhx6 http://www.ncbi.nlm.nih.gov/gene/?term=16874 Lhx6.1 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004454 168850 ZNF800 http://www.ncbi.nlm.nih.gov/gene/?term=168850 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004455 168850 ZNF800 http://www.ncbi.nlm.nih.gov/gene/?term=168850 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004456 16898 Rps2 http://www.ncbi.nlm.nih.gov/gene/?term=16898 "Llrep3, S4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004457 16898 Rps2 http://www.ncbi.nlm.nih.gov/gene/?term=16898 "Llrep3, S4 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00004458 16905 Lmna http://www.ncbi.nlm.nih.gov/gene/?term=16905 Dhe mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004459 16905 Lmna http://www.ncbi.nlm.nih.gov/gene/?term=16905 Dhe mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004460 1690 COCH http://www.ncbi.nlm.nih.gov/gene/?term=1690 "COCH-5B2, COCH5B2, DFNA9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004461 1690 COCH http://www.ncbi.nlm.nih.gov/gene/?term=1690 "COCH-5B25B2, DFNA9, COCH " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004462 169166 SNX31 http://www.ncbi.nlm.nih.gov/gene/?term=169166 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004463 169200 TMEM64 http://www.ncbi.nlm.nih.gov/gene/?term=169200 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004464 16939 Lor http://www.ncbi.nlm.nih.gov/gene/?term=16939 "AI036317, S77319 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004465 16952 Anxa1 http://www.ncbi.nlm.nih.gov/gene/?term=16952 "Anx-1, Anx-A1, C430014K04Rik, Lpc-1, Lpc1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004466 169611 OLFML2A http://www.ncbi.nlm.nih.gov/gene/?term=169611 PRO34319 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004467 169611 OLFML2A http://www.ncbi.nlm.nih.gov/gene/?term=169611 PRO34319 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004468 169714 QSOX2 http://www.ncbi.nlm.nih.gov/gene/?term=169714 "QSCN6L1, SOXN " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004469 169714 QSOX2 http://www.ncbi.nlm.nih.gov/gene/?term=169714 "QSCN6L1, SOXN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004470 169714 QSOX2 http://www.ncbi.nlm.nih.gov/gene/?term=169714 "QSCN6L1, SOXN " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004471 16974 Lrp6 http://www.ncbi.nlm.nih.gov/gene/?term=16974 "C030016K15Rik, Cd, Gw, ska26, ska, skax26 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004472 16975 Lrp8 http://www.ncbi.nlm.nih.gov/gene/?term=16975 "4932703M08Rik, AA921429, AI848122, ApoER2, Lr8b " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004473 16979 Lrrn1 http://www.ncbi.nlm.nih.gov/gene/?term=16979 "2810047E21Rik, NLRR-1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004474 16981 Lrrn3 http://www.ncbi.nlm.nih.gov/gene/?term=16981 NLRR-3 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004475 169841 ZNF169 http://www.ncbi.nlm.nih.gov/gene/?term=169841 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004476 16985 Lsp1 http://www.ncbi.nlm.nih.gov/gene/?term=16985 "Lsp-1, WP34, p50, pp52 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004477 16994 Ltb http://www.ncbi.nlm.nih.gov/gene/?term=16994 "AI662801, LTbeta, Tnfc, Tnfsf3, Tnlg1c, p33 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004478 16 AARS http://www.ncbi.nlm.nih.gov/gene/?term=16 "CMT2N, EIEE29 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004479 16 AARS http://www.ncbi.nlm.nih.gov/gene/?term=16 "CMT2N, EIEE29 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004480 16 AARS http://www.ncbi.nlm.nih.gov/gene/?term=16 "CMT2N, EIEE29 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004481 17005 Ltk http://www.ncbi.nlm.nih.gov/gene/?term=17005 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004482 170082 TCEANC http://www.ncbi.nlm.nih.gov/gene/?term=170082 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004483 170384 FUT11 http://www.ncbi.nlm.nih.gov/gene/?term=170384 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004484 170392 OIT3 http://www.ncbi.nlm.nih.gov/gene/?term=170392 LZP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004485 170439 Elovl6 http://www.ncbi.nlm.nih.gov/gene/?term=170439 "C77826, FAE, LCE " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004486 170463 SSBP4 http://www.ncbi.nlm.nih.gov/gene/?term=170463 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004487 170463 SSBP4 http://www.ncbi.nlm.nih.gov/gene/?term=170463 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004488 170506 DHX36 http://www.ncbi.nlm.nih.gov/gene/?term=170506 "DDX36, G4R1, MLEL1, RHAU " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004489 170506 DHX36 http://www.ncbi.nlm.nih.gov/gene/?term=170506 "DDX36, G4R1, MLEL1, RHAU " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004490 17057 Klrb1a http://www.ncbi.nlm.nih.gov/gene/?term=17057 "Ly55a, NKR-P1.7, NKR-P1A, NKRP12, Nkrp1-a, Nkrp1a, ly-55A " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004491 170622 COMMD6 http://www.ncbi.nlm.nih.gov/gene/?term=170622 Acrg mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004492 170622 COMMD6 http://www.ncbi.nlm.nih.gov/gene/?term=170622 Acrg mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004493 170622 COMMD6 http://www.ncbi.nlm.nih.gov/gene/?term=170622 Acrg mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004494 170626 XAGE3 http://www.ncbi.nlm.nih.gov/gene/?term=170626 "CT12.3a, CT12.3b, GAGED4, PLAC6, XAGE-3, pp9012 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004495 170639 Olfr78 http://www.ncbi.nlm.nih.gov/gene/?term=170639 "4633402A21Rik, MOL2.3, MOR18-2, Or51e2, PSGR, RA1c " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004496 170679 PSORS1C1 http://www.ncbi.nlm.nih.gov/gene/?term=170679 "C6orf16, SEEK1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004497 170691 ADAMTS17 http://www.ncbi.nlm.nih.gov/gene/?term=170691 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004498 170691 ADAMTS17 http://www.ncbi.nlm.nih.gov/gene/?term=170691 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004499 170691 ADAMTS17 http://www.ncbi.nlm.nih.gov/gene/?term=170691 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004500 170707 Usp48 http://www.ncbi.nlm.nih.gov/gene/?term=170707 "2810449C13Rik, AI115503, BC021769, D330022K21Rik, Usp31 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004501 170740 Zfp287 http://www.ncbi.nlm.nih.gov/gene/?term=170740 "B230333C16Rik, SKAT-2, Skat2, Znf287, mszf16, mszf74 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004502 170742 Sertad3 http://www.ncbi.nlm.nih.gov/gene/?term=170742 "AW124805, D1Mgi51, Rbt1, Sei3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004503 170758 Rac3 http://www.ncbi.nlm.nih.gov/gene/?term=170758 Rac1B mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004504 170760 Acbd3 http://www.ncbi.nlm.nih.gov/gene/?term=170760 "60kDa, 8430407O11Rik, D1Ertd10e, GCP60, GOLPH1, Gocap1, Pap7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004505 170762 Nup155 http://www.ncbi.nlm.nih.gov/gene/?term=170762 "D930027M19Rik, mKIAA0791 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004506 17076 Ly75 http://www.ncbi.nlm.nih.gov/gene/?term=17076 "CD205, DEC-205, DEC205 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004507 170770 Bbc3 http://www.ncbi.nlm.nih.gov/gene/?term=170770 "PUMA, PUMA/JFY1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004508 170789 Acot8 http://www.ncbi.nlm.nih.gov/gene/?term=170789 "PTE-2, Pte1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004509 170791 Rbm39 http://www.ncbi.nlm.nih.gov/gene/?term=170791 "1500012C14Rik, 2310040E03Rik, B330012G18Rik, C79248, R75070, Rnpc2, caper " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004510 170822 Usp33 http://www.ncbi.nlm.nih.gov/gene/?term=170822 "9830169D19Rik, AA409780, Vdu1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004511 170823 Glmn http://www.ncbi.nlm.nih.gov/gene/?term=170823 "9330160J16Rik, AW227515, Fap48, Fap68 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004512 17082 Il1rl1 http://www.ncbi.nlm.nih.gov/gene/?term=17082 "DER4, Fit-1, Ly84, ST2L, St2, St2-rs1, T1, T1/ST2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004513 17085 Ly9 http://www.ncbi.nlm.nih.gov/gene/?term=17085 "AI893573, CD229, Lgp100, Ly-9, SLAMF3, T100 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004514 17087 Ly96 http://www.ncbi.nlm.nih.gov/gene/?term=17087 "ESOP-1, MD-2, MD2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004515 170930 Sumo2 http://www.ncbi.nlm.nih.gov/gene/?term=170930 "SUMO-2, Smt3A, Smt3b, Smt3h2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004516 170930 Sumo2 http://www.ncbi.nlm.nih.gov/gene/?term=170930 "Smt3A, Smt3b, SUMO-2, Smt3h2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004517 170938 Zfp617 http://www.ncbi.nlm.nih.gov/gene/?term=170938 Zfps11-6 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004518 170942 Erdr1 http://www.ncbi.nlm.nih.gov/gene/?term=170942 edr mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004519 170954 PPP1R18 http://www.ncbi.nlm.nih.gov/gene/?term=170954 "HKMT1098, KIAA1949 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004520 170958 ZNF525 http://www.ncbi.nlm.nih.gov/gene/?term=170958 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004521 171017 ZNF384 http://www.ncbi.nlm.nih.gov/gene/?term=171017 "CAGH1, CAGH1A, CIZ, ERDA2, NMP4, NP, TNRC1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004522 171017 ZNF384 http://www.ncbi.nlm.nih.gov/gene/?term=171017 "CAGH1, CAGH1A, CIZ, ERDA2, NMP4, NP, TNRC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004523 17101 Lyst http://www.ncbi.nlm.nih.gov/gene/?term=17101 "D13Sfk13, beige, bg " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004524 171023 ASXL1 http://www.ncbi.nlm.nih.gov/gene/?term=171023 "BOPS, MDS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004525 171023 ASXL1 http://www.ncbi.nlm.nih.gov/gene/?term=171023 "BOPS, MDS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004526 171024 SYNPO2 http://www.ncbi.nlm.nih.gov/gene/?term=171024 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004527 171024 SYNPO2 http://www.ncbi.nlm.nih.gov/gene/?term=171024 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004528 171024 SYNPO2 http://www.ncbi.nlm.nih.gov/gene/?term=171024 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004529 171162 Reg3a http://www.ncbi.nlm.nih.gov/gene/?term=171162 "Pap2, PapII " mRNA Rattus norvegicus 26180210 Axon Spinal cord In situ hybridization "By quantitative fluorescent in situ hybridization combined with immunofluorescence to unambiguously distinguish intra-axonal mRNAs, we show that regenerating spinal cord axons contain β-actin, GAP-43, Neuritin, Reg3a, Hamp, and Importin β1 mRNAs. " RLID00004530 171166 Mcoln3 http://www.ncbi.nlm.nih.gov/gene/?term=171166 "6720490O21Rik, TRPML3, Va " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004531 17118 Marcks http://www.ncbi.nlm.nih.gov/gene/?term=17118 "Macs, PKCSL " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004532 171199 Vmn1r18 http://www.ncbi.nlm.nih.gov/gene/?term=171199 V1rc26 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004533 171212 Galnt10 http://www.ncbi.nlm.nih.gov/gene/?term=171212 "AU018154, C330012K04Rik, GalNAc-T10, GalNAc-T9, Galnt9, ppGaNTase " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004534 171228 Vmn1r225 http://www.ncbi.nlm.nih.gov/gene/?term=171228 V1re5 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004535 17122 Mxd4 http://www.ncbi.nlm.nih.gov/gene/?term=17122 "2810410A03Rik, Mad4, bHLHc12 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004536 17122 Mxd4 http://www.ncbi.nlm.nih.gov/gene/?term=17122 "2810410A03Rik, Mad4, bHLHc12 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004537 171230 Vmn1r231 http://www.ncbi.nlm.nih.gov/gene/?term=171230 "V1re5, V1re7 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004538 171236 Vmn1r233 http://www.ncbi.nlm.nih.gov/gene/?term=171236 V1rf5 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004539 171244 Vmn1r81 http://www.ncbi.nlm.nih.gov/gene/?term=171244 V1rg9 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004540 171250 Vmn1r206 http://www.ncbi.nlm.nih.gov/gene/?term=171250 V1rh7 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004541 171269 Vmn1r210 http://www.ncbi.nlm.nih.gov/gene/?term=171269 V1rh10 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004542 171271 Vmn1r220 http://www.ncbi.nlm.nih.gov/gene/?term=171271 V1rh12 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004543 171274 Vmn1r222 http://www.ncbi.nlm.nih.gov/gene/?term=171274 V1rh16 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004544 171285 Havcr2 http://www.ncbi.nlm.nih.gov/gene/?term=171285 "TIM-3, Tim3, Timd3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004545 17128 Smad4 http://www.ncbi.nlm.nih.gov/gene/?term=17128 "AW743858, D18Wsu70e, DPC4, Madh4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004546 17132 Maf http://www.ncbi.nlm.nih.gov/gene/?term=17132 "2810401A20Rik, A230108G15Rik, AW047063, c-maf " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004547 17133 Maff http://www.ncbi.nlm.nih.gov/gene/?term=17133 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004548 17134 Mafg http://www.ncbi.nlm.nih.gov/gene/?term=17134 "AA545192, C630022N07Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004549 171361 Eef1a1 http://www.ncbi.nlm.nih.gov/gene/?term=171361 "EEF-1, EEF1A, EF1A, Eef1a2, Eef1a2l1, SI " mRNA Rattus norvegicus 16079402 Dendrite Hippocampus In situ hybridization|Immunofluorescence assay "We demonstrate here that the mRNA for the elongation factor 1 alpha (EF1alpha) is present in vivo in the dendrites of neurons that exhibit LTP and LTD, and that its translation is locally regulated. " RLID00004550 171381 Psd http://www.ncbi.nlm.nih.gov/gene/?term=171381 EFA6 mRNA Rattus norvegicus 15009133 Cell body Hippocampus In situ hybridization "Our results provided definitive evidence for somatodendritic localization of EFA6A mRNA in both cultured and in vivo hyppocampal neurons by nonradioactive in situ hybridization. In both in vivo and cultured hyppocampal neurons, the signal for EFA6A mRNA was detected in the dendrites as well as cell bodies.(Fig.2B and D) " RLID00004551 171381 Psd http://www.ncbi.nlm.nih.gov/gene/?term=171381 EFA6 mRNA Rattus norvegicus 15009133 Dendrite Hippocampus In situ hybridization "Our results provided definitive evidence for somatodendritic localization of EFA6A mRNA in both cultured and in vivo hyppocampal neurons by nonradioactive in situ hybridization. In both in vivo and cultured hyppocampal neurons, the signal for EFA6A mRNA was detected in the dendrites as well as cell bodies.(Fig.2B and D) " RLID00004552 171392 ZNF675 http://www.ncbi.nlm.nih.gov/gene/?term=171392 "TBZF, TIZ " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004553 171425 CLYBL http://www.ncbi.nlm.nih.gov/gene/?term=171425 CLB mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004554 171463 Il17rd http://www.ncbi.nlm.nih.gov/gene/?term=171463 "2810004A10Rik, AI428510, Sef, Sef-S " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004555 171504 Apobr http://www.ncbi.nlm.nih.gov/gene/?term=171504 "Apob-48r, Apob48r " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004556 171546 SPTSSA http://www.ncbi.nlm.nih.gov/gene/?term=171546 "C14orf147, SSSPTA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004557 171546 SPTSSA http://www.ncbi.nlm.nih.gov/gene/?term=171546 "C14orf147, SSSPTA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004558 171568 POLR3H http://www.ncbi.nlm.nih.gov/gene/?term=171568 "RPC22.9, RPC8 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004559 17156 Man1a2 http://www.ncbi.nlm.nih.gov/gene/?term=17156 "AI428775, AI528764, AI854422, Man1b, PCR2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004560 17156 Man1a2 http://www.ncbi.nlm.nih.gov/gene/?term=17156 "AI428775, AI528764, AI854422, Man1b, PCR2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004561 171586 ABHD3 http://www.ncbi.nlm.nih.gov/gene/?term=171586 LABH3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004562 17158 Man2a1 http://www.ncbi.nlm.nih.gov/gene/?term=17158 "Mana-2, Mana2, Map-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004563 17164 Mapkapk2 http://www.ncbi.nlm.nih.gov/gene/?term=17164 "AA960234, MAPKAP-K2, MK-2, MK2, Rps6kc1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004564 17164 Mapkapk2 http://www.ncbi.nlm.nih.gov/gene/?term=17164 "AA960234, MAPKAP-K2, MK-2, MK2, Rps6kc1 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00004565 17165 Mapkapk5 http://www.ncbi.nlm.nih.gov/gene/?term=17165 "MK5, PRAK " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004566 17168 Nprl3 http://www.ncbi.nlm.nih.gov/gene/?term=17168 "Aag, CGTHBA, HS-26, HS-40, Mare, Phg, Prox1, m(alpha)RE " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004567 1716 DGUOK http://www.ncbi.nlm.nih.gov/gene/?term=1716 "MTDPS3, dGK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004568 1716 DGUOK http://www.ncbi.nlm.nih.gov/gene/?term=1716 "MTDPS3, dGK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004569 1716 DGUOK http://www.ncbi.nlm.nih.gov/gene/?term=1716 "MTDPS3, dGK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004570 17175 Masp2 http://www.ncbi.nlm.nih.gov/gene/?term=17175 "MASP-2, MAp19 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004571 1717 DHCR7 http://www.ncbi.nlm.nih.gov/gene/?term=1717 SLOS mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004572 1717 DHCR7 http://www.ncbi.nlm.nih.gov/gene/?term=1717 SLOS mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004573 17180 Matn1 http://www.ncbi.nlm.nih.gov/gene/?term=17180 "CMP, Crtm, Mat1, matrilin-1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004574 17181 Matn2 http://www.ncbi.nlm.nih.gov/gene/?term=17181 "Crtm2, matrilin-2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004575 17183 Matn4 http://www.ncbi.nlm.nih.gov/gene/?term=17183 matrilin-4 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004576 17184 Matr3 http://www.ncbi.nlm.nih.gov/gene/?term=17184 "1110061A14Rik, 2810017I02Rik, AI841759, AW555618, D030046F20Rik, mKIAA0723 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004577 1718 DHCR24 http://www.ncbi.nlm.nih.gov/gene/?term=1718 "DCE, Nbla03646, SELADIN1, seladin-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004578 1718 DHCR24 http://www.ncbi.nlm.nih.gov/gene/?term=1718 "DCE, Nbla03646, SELADIN1, seladin-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004579 1718 DHCR24 http://www.ncbi.nlm.nih.gov/gene/?term=1718 "DCE, Nbla03646, SELADIN1, seladin-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004580 17192 Mbd3 http://www.ncbi.nlm.nih.gov/gene/?term=17192 "AI181826, AU019209 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004581 17196 Mbp http://www.ncbi.nlm.nih.gov/gene/?term=17196 "C76307, Hmbpr, R75289, golli-mbp, jve, mld, shi " mRNA Mus musculus 7877439 Cytoplasm Brain In situ hybridization This mRNA distribution pattern was maintained into adulthood and was consistent with the presence of MBP mRNA in distal cytoplasmic regions. RLID00004582 1719 DHFR http://www.ncbi.nlm.nih.gov/gene/?term=1719 "DHFRP1, DYR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004583 1719 DHFR http://www.ncbi.nlm.nih.gov/gene/?term=1719 "DHFRP1, DYR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004584 17217 Mcm4 http://www.ncbi.nlm.nih.gov/gene/?term=17217 "19G, AI325074, AU045576, Cdc21, Mcmd4, mKIAA4003, mcdc21 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004585 17220 Mcm7 http://www.ncbi.nlm.nih.gov/gene/?term=17220 "AI747533, Mcmd7, mCDC47 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004586 17222 Anapc1 http://www.ncbi.nlm.nih.gov/gene/?term=17222 "2610021O03Rik, AI047775, AI853536, AW547281, Apc1, Mcpr, tsg24 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004587 1723 DHODH http://www.ncbi.nlm.nih.gov/gene/?term=1723 "DHOdehase, POADS, URA1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004588 17240 Mdfi http://www.ncbi.nlm.nih.gov/gene/?term=17240 "I-mf, I-mfa " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004589 17240 Mdfi http://www.ncbi.nlm.nih.gov/gene/?term=17240 "I-mf, I-mfa " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004590 17246 Mdm2 http://www.ncbi.nlm.nih.gov/gene/?term=17246 "1700007J15Rik, AA415488, Mdm-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004591 17248 Mdm4 http://www.ncbi.nlm.nih.gov/gene/?term=17248 "4933417N07Rik, AA414968, AL023055, AU018793, AU021806, C85810, Mdmx " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004592 17250 Abcc1 http://www.ncbi.nlm.nih.gov/gene/?term=17250 "Abcc1ab, MRP, Mdrap, Mrp1, Abcc1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004593 17256 Mea1 http://www.ncbi.nlm.nih.gov/gene/?term=17256 Mea-1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004594 17258 Mef2a http://www.ncbi.nlm.nih.gov/gene/?term=17258 A430079H05Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004595 17259 Mef2b http://www.ncbi.nlm.nih.gov/gene/?term=17259 AI451606 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004596 1725 DHPS http://www.ncbi.nlm.nih.gov/gene/?term=1725 "DHS, DS, MIG13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004597 1725 DHPS http://www.ncbi.nlm.nih.gov/gene/?term=1725 "DHS, DS, MIG13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004598 17260 Mef2c http://www.ncbi.nlm.nih.gov/gene/?term=17260 "5430401D19Rik, 9930028G15Rik, AV011172, Mef2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004599 17261 Mef2d http://www.ncbi.nlm.nih.gov/gene/?term=17261 C80750 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004600 17263 Meg3 http://www.ncbi.nlm.nih.gov/gene/?term=17263 "2900016C05Rik, 3110050O07Rik, 6330408G06Rik, AI425946, AW108224, D12Bwg1266e, Gtl2, R74756, R75394 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004601 17263 Meg3 http://www.ncbi.nlm.nih.gov/gene/?term=17263 "2900016C05Rik, 3110050O07Rik, 6330408G06Rik, AI425946, AW108224, D12Bwg1266e, Gtl2, R74756, R75394 " lncRNA Mus musculus 26464439 Axon Motoneuron In situ hybridization|qRT-PCR "We then analyzed the abundance of several lncRNAs, namely Malat1, Meg3, Rmst, Xist and Miat. All of these lncRNAs were present in the axonal compartment. " RLID00004602 17268 Meis1 http://www.ncbi.nlm.nih.gov/gene/?term=17268 "C530044H18Rik, Evi8 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004603 17268 Meis1 http://www.ncbi.nlm.nih.gov/gene/?term=17268 "C530044H18Rik, Evi8 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004604 17276 Mela http://www.ncbi.nlm.nih.gov/gene/?term=17276 "80kDa, Ag, env, gag, gag-pol, pol " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004605 1727 CYB5R3 http://www.ncbi.nlm.nih.gov/gene/?term=1727 "B5R, DIA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004606 1727 CYB5R3 http://www.ncbi.nlm.nih.gov/gene/?term=1727 "B5R, DIA1 " mRNA Homo sapiens 21266463 Endoplasmic reticulum Foreskin fibroblast RT-PCR The combined results from our multiple approaches consistently demonstrate that Dia1 mRNA is localized on the ER membrane. Fig. 3. Dia1 mRNA is localized on the ER. RLID00004607 17283 Men1 http://www.ncbi.nlm.nih.gov/gene/?term=17283 AW045611 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004608 17285 Meox1 http://www.ncbi.nlm.nih.gov/gene/?term=17285 "AI385561, D330041M02Rik, Mox-1, Mox1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004609 17289 Mertk http://www.ncbi.nlm.nih.gov/gene/?term=17289 "Eyk, Mer, Nyk, nmf12 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004610 1728 NQO1 http://www.ncbi.nlm.nih.gov/gene/?term=1728 "DHQU, DIA4, DTD, NMOR1, NMORI, QR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004611 1728 NQO1 http://www.ncbi.nlm.nih.gov/gene/?term=1728 "DHQU, DIA4, DTD, NMOR1, NMORI, QR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004612 1728 NQO1 http://www.ncbi.nlm.nih.gov/gene/?term=1728 "DHQU, DIA4, DTD, NMOR1, NMORI, QR1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004613 1728 NQO1 http://www.ncbi.nlm.nih.gov/gene/?term=1728 "DHQU, DIA4, DTD, NMOR1, NMORI, QR1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004614 17295 Met http://www.ncbi.nlm.nih.gov/gene/?term=17295 "AI838057, HGF, HGFR, Par4, c-Met " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004615 1729 DIAPH1 http://www.ncbi.nlm.nih.gov/gene/?term=1729 "DFNA1, DIA1, DRF1, LFHL1, SCBMS, hDIA1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004616 17305 Mfng http://www.ncbi.nlm.nih.gov/gene/?term=17305 AW546563 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004617 17318 Mid1 http://www.ncbi.nlm.nih.gov/gene/?term=17318 "61B3-R, DXHXS1141, Fxy, Trim18 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004618 17330 Minpp1 http://www.ncbi.nlm.nih.gov/gene/?term=17330 AA408516 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004619 17347 Mknk2 http://www.ncbi.nlm.nih.gov/gene/?term=17347 "2010016G11Rik, Gprk7, Mnk2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004620 17356 Mllt4 http://www.ncbi.nlm.nih.gov/gene/?term=17356 "5033403D15Rik, AF6, Af-6, Afadin, Gm314, I-afadin, S-afadin " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004621 1735 DIO3 http://www.ncbi.nlm.nih.gov/gene/?term=1735 "5DIII, D3, DIOIII, TXDI3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004622 1736 DKC1 http://www.ncbi.nlm.nih.gov/gene/?term=1736 "CBF5, DKC, DKCX, NAP57, NOLA4, XAP101 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004623 1736 DKC1 http://www.ncbi.nlm.nih.gov/gene/?term=1736 "CBF5, DKC, DKCX, NAP57, NOLA4, XAP101 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004624 1737 DLAT http://www.ncbi.nlm.nih.gov/gene/?term=1737 "DLTA, PDC-E2, PDCE2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004625 1737 DLAT http://www.ncbi.nlm.nih.gov/gene/?term=1737 "DLTA, PDC-E2, PDCE2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004626 1738 DLD http://www.ncbi.nlm.nih.gov/gene/?term=1738 "DLDD, DLDH, E3, GCSL, LAD, PHE3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004627 1738 DLD http://www.ncbi.nlm.nih.gov/gene/?term=1738 "DLDDH, E3, GCSL, LAD, PHE3, DLD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004628 17390 Mmp2 http://www.ncbi.nlm.nih.gov/gene/?term=17390 "Clg4a, GelA, MMP-2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004629 17395 Mmp9 http://www.ncbi.nlm.nih.gov/gene/?term=17395 "AW743869, B/MMP9, Clg4b, Gel B, MMP-9, pro-MMP-9 " mRNA Mus musculus 24227732 Dendrite Oocyte In situ hybridization Here we show that MMP-9 mRNA is part of the FMRP complex and colocalizes in dendrites. Endogenous MMP-9 mRNA was revealed by in situ hybridization combined with immunodetection of FMRP. MMP-9 mRNA was localized in granules along the dendrites and exhibited abundant colocalization with FMRP (Fig. 3C). RLID00004630 1739 DLG1 http://www.ncbi.nlm.nih.gov/gene/?term=1739 "DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004631 1739 DLG1 http://www.ncbi.nlm.nih.gov/gene/?term=1739 "DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004632 1741 DLG3 http://www.ncbi.nlm.nih.gov/gene/?term=1741 "MRX, MRX90, NEDLG, PPP1R82, SAP102, XLMR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004633 17420 Mnat1 http://www.ncbi.nlm.nih.gov/gene/?term=17420 "E130115E11Rik, MAT1, P36 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004634 1742 DLG4 http://www.ncbi.nlm.nih.gov/gene/?term=1742 "PSD95, SAP-90, SAP90 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004635 1743 DLST http://www.ncbi.nlm.nih.gov/gene/?term=1743 DLTS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004636 17450 Morc1 http://www.ncbi.nlm.nih.gov/gene/?term=17450 Morc mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004637 17472 Gbp4 http://www.ncbi.nlm.nih.gov/gene/?term=17472 "AW228052, Mag-2, Mpa-2, Mpa2, mKIAA4245 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004638 17475 Mpdz http://www.ncbi.nlm.nih.gov/gene/?term=17475 "AI225843, B930003D11Rik, MUPP1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004639 1748 DLX4 http://www.ncbi.nlm.nih.gov/gene/?term=1748 "BP1, DLX7, DLX8, DLX9, OFC15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004640 1749 DLX5 http://www.ncbi.nlm.nih.gov/gene/?term=1749 SHFM1D mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004641 174 AFP http://www.ncbi.nlm.nih.gov/gene/?term=174 "AFPD, FETA, HPAFP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004642 17532 Mras http://www.ncbi.nlm.nih.gov/gene/?term=17532 "2900078C09Rik, AI326250 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004643 17535 Mre11a http://www.ncbi.nlm.nih.gov/gene/?term=17535 "Mre11, Mre11b " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004644 17537 Meis3 http://www.ncbi.nlm.nih.gov/gene/?term=17537 "AI573393, Mrg2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004645 1759 DNM1 http://www.ncbi.nlm.nih.gov/gene/?term=1759 "DNM, EIEE31 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004646 175 AGA http://www.ncbi.nlm.nih.gov/gene/?term=175 "AGU, ASRG, GA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004647 1760 DMPK http://www.ncbi.nlm.nih.gov/gene/?term=1760 "DM, DM1, DM1PK, DMK, MDPK, MT-PK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004648 1762 DMWD http://www.ncbi.nlm.nih.gov/gene/?term=1762 "D19S593E, DMR-N9, DMRN9, gene59 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004649 1763 DNA2 http://www.ncbi.nlm.nih.gov/gene/?term=1763 "DNA2L, hDNA2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004650 1763 DNA2 http://www.ncbi.nlm.nih.gov/gene/?term=1763 "DNA2L, hDNA2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004651 17686 Msh3 http://www.ncbi.nlm.nih.gov/gene/?term=17686 "D13Em1, Rep-3, Rep3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004652 17688 Msh6 http://www.ncbi.nlm.nih.gov/gene/?term=17688 "AU044881, AW550279, GTBP, Gtmbp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004653 1768 DNAH6 http://www.ncbi.nlm.nih.gov/gene/?term=1768 "DNHL1, Dnahc6, HL-2, HL2 " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00004654 17692 Msl3 http://www.ncbi.nlm.nih.gov/gene/?term=17692 "AU0189311, Msl3l1, Msl3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004655 1773 DNASE1 http://www.ncbi.nlm.nih.gov/gene/?term=1773 "DNL1, DRNI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004656 1774 DNASE1L1 http://www.ncbi.nlm.nih.gov/gene/?term=1774 "DNAS1L1, DNASEX, DNL1L, G4.8, XIB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004657 17751 Mt3 http://www.ncbi.nlm.nih.gov/gene/?term=17751 Mt-3 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004658 17754 Map1a http://www.ncbi.nlm.nih.gov/gene/?term=17754 "6330416M19Rik, AI853608, Mtap-1, Mtap1, Mtap1a, moth1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004659 17755 Map1b http://www.ncbi.nlm.nih.gov/gene/?term=17755 "A230055D22, AI843217, LC1, MAP5, Mtap-5, Mtap1b, Mtap5 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004660 17755 Map1b http://www.ncbi.nlm.nih.gov/gene/?term=17755 "A230055D22, AI843217, LC1, MAP5, Mtap-5, Mtap1b, Mtap5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004661 17755 Map1b http://www.ncbi.nlm.nih.gov/gene/?term=17755 "A230055D22, AI843217, LC1, MAP5, Mtap-5, Mtap1b, Mtap5 " mRNA Mus musculus 16631377 Growth cone Hippocampus Fluorescence in situ hybridization "MAP1b mRNA, a known FMRP target, was also localized to axon growth cones. " RLID00004662 17755 Map1b http://www.ncbi.nlm.nih.gov/gene/?term=17755 "A230055D22, AI843217, LC1, MAP5, Mtap-5, Mtap1b, Mtap5 " mRNA Mus musculus 18539120 Dendrite Neuron Fluorescence in situ hybridization "Fig. 1 Fluorescence in situ hybridization (FISH) of hippocampal neurons. (a-d) Neurons from wild-type (WT, right panels) or FMRP-knockout (KO, left panels) were cultured for 10 days and either not stimulated ('unstim', upper panels') or stimulated with 50uM DHPG for 15 minutes ('DHPG' lower panels). Corresponding histograms showing dendritic quantification of FISH experiments are shown to the right. Results for WT (black bars) and KO (white bars) are labeled on the x-axis. Close-up images of dendritic signals are shown to the right (in same order). (a) MAP1b mRNA (n=15-16; *p<0.001 for unstimulated vs. DHPG in WT, P>0.25 for KO). (b)CaMKIIa mRNA (n=15-17; *p<0.01 for WT, p>0.2 for KO). There was no significant difference in CaMKIIa abundance of unstimulated neurons between WT and KO (n=15, p>0.1). (c) Beta-actin mRNA (n=11-13; p>0.2). Scale bars=12um. (d-e) FISH for other mRNA targets of FMRP in both WT (right image panels) and KO (left image panels). Representative images shown for unstimulated (upper panels; 'unstim' and stimulated (lower panels; DHPG, 50uM), and close-up images of dendrites are displayed above the histograms (in same order). Histograms (right) showing dendritic fluorescence quantification are shown for WT (green) and KO (red) using probes to (d) SAPAP4 (n=16-17; p<0.01 for WT, p>25 for KO) and (e) GABA-A receptor delta (n=13-15; *, ***p<0.01 for unstimulated vs. DHPG in WT and for DHPG in WT and KO, **p<0.05 for unstimulated vs. DHPG in KO). (c) Dendritic CaMKIIa mRNA localization in response to DHPG (11DIV). (d) Dendritic SAPAP4 mRNA localization in response to DHPG (11DIV). " RLID00004663 17755 Map1b http://www.ncbi.nlm.nih.gov/gene/?term=17755 "A230055D22, AI843217, LC1, MAP5, Mtap-5, Mtap1b, Mtap5 " mRNA Mus musculus 18539120 Synapse Brain qRT-PCR "The mRNA targets reduced in Kif5 association included genes involved in actin remodeling at synapses (cofilin phosphatase (PP2Ac); p116-RIP), synapse-associated signaling (DAG1;RGS5) and synapse structure (SAPAP4; CaMKIIa; MAP1b). Not all mRNAs were significantly reduced in Kif5 IPs, as OCRL1 mRNA was similar in KO brain (P>0.05, n=8). " RLID00004664 17755 Map1b http://www.ncbi.nlm.nih.gov/gene/?term=17755 "A230055D22, AI843217, LC1, MAP5, Mtap-5, Mtap1b, Mtap5 " mRNA Mus musculus 16098134 Synapse Hippocampus In situ hybridization|Immunofluorescence assay "MAP1B mRNA [Fig. 3(a), green] was dendritically localized in granules and exhibited abundant colocalization with FMRP (red, inset). A Z-series followed by deconvolution and volume rendering of the boxed dendrite in Fig. 3(a) depicts FMRP and MAP1B mRNA that colocalized in granules (yellow) at synapses (synapsin staining, blue) [Fig. 3(b), insets a, b]. " RLID00004665 17755 Map1b http://www.ncbi.nlm.nih.gov/gene/?term=17755 "A230055D22, AI843217, LC1, MAP5, Mtap-5, Mtap1b, Mtap5 " mRNA Mus musculus 16098134 Dendrite Hippocampus In situ hybridization|Immunofluorescence assay "MAP1B mRNA [Fig. 3(a), green] was dendritically localized in granules and exhibited abundant colocalization with FMRP (red, inset). A Z-series followed by deconvolution and volume rendering of the boxed dendrite in Fig. 3(a) depicts FMRP and MAP1B mRNA that colocalized in granules (yellow) at synapses (synapsin staining, blue) [Fig. 3(b), insets a, b]. " RLID00004666 17756 Map2 http://www.ncbi.nlm.nih.gov/gene/?term=17756 "G1-397-34, MAP-2, Mtap-2, Mtap2, repro4 " mRNA Mus musculus 15328607 Dendrite Retina In situ hybridization "We found that in contrast to rodent MAP2 mRNAs, which are highly enriched in dendritic regions of the retina, chicken MAP2 transcripts are virtually absent from such areas and are rather connected to neuronal somata. The combined data suggest that in the mouse retina, MAP2 mRNA is located predominantly in layers rich in dendrites whereas in the chicken retina, MAP2 mRNA is largely con?ned to neuronal somata. " RLID00004667 17756 Map2 http://www.ncbi.nlm.nih.gov/gene/?term=17756 "G1-397-34, MAP-2, Mtap-2, Mtap2, repro4 " mRNA Mus musculus 8647897 Dendrite Mature neuron In situ hybridization "Initially, each was detected in axons and dendrites, although tau persisted only in axons, whereas MAP2C and MAP2 were restricted to cell bodies and dendrites. " RLID00004668 17756 Map2 http://www.ncbi.nlm.nih.gov/gene/?term=17756 "G1-397-34, MAP-2, Mtap-2, Mtap2, repro4 " mRNA Mus musculus 8647897 Cell body Mature neuron In situ hybridization "Initially, each was detected in axons and dendrites, although tau persisted only in axons, whereas MAP2C and MAP2 were restricted to cell bodies and dendrites. " RLID00004669 17762 Mapt http://www.ncbi.nlm.nih.gov/gene/?term=17762 "AI413597, AW045860, Mtapt, Tau " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004670 17762 Mapt http://www.ncbi.nlm.nih.gov/gene/?term=17762 "AI413597, AW045860, Mtapt, Tau " mRNA Mus musculus 11517247 Axon Embryo In situ hybridization We demonstrated colocalization of the targeted tau mRNA and its translated protein in the axon and growth cone. RLID00004671 17762 Mapt http://www.ncbi.nlm.nih.gov/gene/?term=17762 "AI413597, AW045860, Mtapt, Tau " mRNA Mus musculus 11517247 Cell body Embryo In situ hybridization Both tau mRNA and tau protein remained in the cell body. RLID00004672 17762 Mapt http://www.ncbi.nlm.nih.gov/gene/?term=17762 "AI413597, AW045860, Mtapt, Tau " mRNA Mus musculus 26512708 Axon ForeBrain Immunoprecipitation|RIP-Chip "HuD has also been implicated in axonal localization of other neuronal mRNAs including Tau, Neuritin/CPG15, Kv.1.1 and CaMKIIα mRNAs " RLID00004673 17762 Mapt http://www.ncbi.nlm.nih.gov/gene/?term=17762 "AI413597, AW045860, Mtapt, Tau " mRNA Mus musculus 8647897 Axon Mature neuron In situ hybridization "Initially, each was detected in axons and dendrites, although tau persisted only in axons, whereas MAP2C and MAP2 were restricted to cell bodies and dendrites. " RLID00004674 17763 Mtcp1 http://www.ncbi.nlm.nih.gov/gene/?term=17763 P13MTCP1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004675 17764 Mtf1 http://www.ncbi.nlm.nih.gov/gene/?term=17764 "MTF-1, Thyls " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004676 17764 Mtf1 http://www.ncbi.nlm.nih.gov/gene/?term=17764 "MTF-1, Thyls " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004677 17765 Mtf2 http://www.ncbi.nlm.nih.gov/gene/?term=17765 "9230112N11Rik, AA537621, C76717, M96, Pcl2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004678 17766 Nudt1 http://www.ncbi.nlm.nih.gov/gene/?term=17766 Mth1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004679 17772 Mtm1 http://www.ncbi.nlm.nih.gov/gene/?term=17772 "AF073996, Mtm, mKIAA4176 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004680 17772 Mtm1 http://www.ncbi.nlm.nih.gov/gene/?term=17772 "AF073996, Mtm, mKIAA4176 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004681 1777 DNASE2 http://www.ncbi.nlm.nih.gov/gene/?term=1777 "DNASE2A, DNL, DNL2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004682 1778 DYNC1H1 http://www.ncbi.nlm.nih.gov/gene/?term=1778 "CMT2O, DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004683 1778 DYNC1H1 http://www.ncbi.nlm.nih.gov/gene/?term=1778 "CMT2O, DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004684 1778 DYNC1H1 http://www.ncbi.nlm.nih.gov/gene/?term=1778 "CMT2O, DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004685 177 AGER http://www.ncbi.nlm.nih.gov/gene/?term=177 RAGE mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004686 1780 DYNC1I1 http://www.ncbi.nlm.nih.gov/gene/?term=1780 "DNCI1, DNCIC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004687 1780 DYNC1I1 http://www.ncbi.nlm.nih.gov/gene/?term=1780 "DNCI1, DNCIC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004688 1781 DYNC1I2 http://www.ncbi.nlm.nih.gov/gene/?term=1781 "DIC74, DNCI2, IC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004689 1781 DYNC1I2 http://www.ncbi.nlm.nih.gov/gene/?term=1781 "DIC74, DNCI2, IC2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004690 17827 Mtx1 http://www.ncbi.nlm.nih.gov/gene/?term=17827 "Gcap6, Mtx " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004691 1783 DYNC1LI2 http://www.ncbi.nlm.nih.gov/gene/?term=1783 "DNCLI2, LIC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004692 1783 DYNC1LI2 http://www.ncbi.nlm.nih.gov/gene/?term=1783 "DNCLI2, LIC2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004693 17840 Mup1 http://www.ncbi.nlm.nih.gov/gene/?term=17840 "Ltn-1, Lvtn-1, Mup-1, Mup-a0, Mup7, Up-1, Mup1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004694 17841 Mup2 http://www.ncbi.nlm.nih.gov/gene/?term=17841 "AA589603, Mup-2, Mup18, Mup4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004695 17847 Usp34 http://www.ncbi.nlm.nih.gov/gene/?term=17847 "A530081C03Rik, Murr2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004696 17847 Usp34 http://www.ncbi.nlm.nih.gov/gene/?term=17847 "A530081C03Rik, Murr2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004697 17850 Mut http://www.ncbi.nlm.nih.gov/gene/?term=17850 "D230010K02Rik, Mcm " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004698 17855 Mvk http://www.ncbi.nlm.nih.gov/gene/?term=17855 "2310010A05Rik, AI256848, AI414037, MK " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004699 17858 Mx2 http://www.ncbi.nlm.nih.gov/gene/?term=17858 "AI528743, Mx-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004700 1785 DNM2 http://www.ncbi.nlm.nih.gov/gene/?term=1785 "CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, LCCS5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004701 17869 Myc http://www.ncbi.nlm.nih.gov/gene/?term=17869 "AU0167572, Niard, Nird, bHLHe39, Myc " mRNA Mus musculus 19003354 Ribosome Fibroblast Hybridisation|Northern blot Globin transcripts with the native globin 3'untranslated region or with the 3'untranslated region of c-myc are present in free/cytoskeletal-bound polysomes. RLID00004702 1786 DNMT1 http://www.ncbi.nlm.nih.gov/gene/?term=1786 "ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004703 1786 DNMT1 http://www.ncbi.nlm.nih.gov/gene/?term=1786 "ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004704 17874 Myd88 http://www.ncbi.nlm.nih.gov/gene/?term=17874 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004705 1787 TRDMT1 http://www.ncbi.nlm.nih.gov/gene/?term=1787 "DMNT2, DNMT2, MHSAIIP, PUMET, RNMT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004706 1787 TRDMT1 http://www.ncbi.nlm.nih.gov/gene/?term=1787 "DMNT2, DNMT2, MHSAIIP, PUMET, RNMT1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004707 1787 TRDMT1 http://www.ncbi.nlm.nih.gov/gene/?term=1787 "DMNT2, DNMT2, MHSAIIP, PUMET, RNMT1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004708 17883 Myh3 http://www.ncbi.nlm.nih.gov/gene/?term=17883 "MyHC-emb, Myhs-e, Myhse " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004709 1788 DNMT3A http://www.ncbi.nlm.nih.gov/gene/?term=1788 "DNMT3A2, M.HsaIIIA, TBRS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004710 178 AGL http://www.ncbi.nlm.nih.gov/gene/?term=178 GDE mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004711 178 AGL http://www.ncbi.nlm.nih.gov/gene/?term=178 GDE mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004712 17906 Myl2 http://www.ncbi.nlm.nih.gov/gene/?term=17906 "MLC-2, MLC-2s/v, MLC-2v, Mlc2v, Mylpc " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004713 17910 Myo15 http://www.ncbi.nlm.nih.gov/gene/?term=17910 "Myo15a, sh-2, sh2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004714 17930 Myom2 http://www.ncbi.nlm.nih.gov/gene/?term=17930 AW146149 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004715 17931 Ppp1r12a http://www.ncbi.nlm.nih.gov/gene/?term=17931 "1200015F06Rik, 5730577I22Rik, AA792106, AV099298, D10Ertd625e, Mypt1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004716 17931 Ppp1r12a http://www.ncbi.nlm.nih.gov/gene/?term=17931 "1200015F06Rik, 5730577I22Rik, AA792106, AV099298, D10Ertd625e, Mypt1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004717 17936 Nab1 http://www.ncbi.nlm.nih.gov/gene/?term=17936 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004718 17937 Nab2 http://www.ncbi.nlm.nih.gov/gene/?term=17937 AI451907 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004719 17938 Naca http://www.ncbi.nlm.nih.gov/gene/?term=17938 "AL022831, AL024382, Gm1878, mKIAA0363, skNAC " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004720 1793 DOCK1 http://www.ncbi.nlm.nih.gov/gene/?term=1793 "DOCK180, ced5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004721 17940 Naip1 http://www.ncbi.nlm.nih.gov/gene/?term=17940 "AV364616, Birc1a, D13Lsd1, Naip, Naip-rs1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004722 1794 DOCK2 http://www.ncbi.nlm.nih.gov/gene/?term=1794 IMD40 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004723 1795 DOCK3 http://www.ncbi.nlm.nih.gov/gene/?term=1795 "MOCA, PBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004724 17965 Nbl1 http://www.ncbi.nlm.nih.gov/gene/?term=17965 "D4H1S1733E, DAN, Dana, NO3 " mRNA Mus musculus 11134349 Axon Fetus In situ hybridization "In order to understand better the in vivo roles of DAN, we designed bioassays for BMP blockade within the Xenopus embryo, examined Dan expression in the mouse, and generated mice that lacked DAN function. In this way, we have shown that DAN may bind GDF-5 in vivo, that Dan mRNA is localized in many developing axon tracts, and that Dan mutant mice have only subtle defects. " RLID00004725 1796 DOK1 http://www.ncbi.nlm.nih.gov/gene/?term=1796 "P62DOK, pp62 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004726 17973 Nck1 http://www.ncbi.nlm.nih.gov/gene/?term=17973 "6330586M15Rik, D230010O13Rik, Nck, Nck-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004727 17975 Ncl http://www.ncbi.nlm.nih.gov/gene/?term=17975 "B530004O11Rik, C23, D0Nds28, D1Nds28, Nucl " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004728 17979 Ncoa3 http://www.ncbi.nlm.nih.gov/gene/?term=17979 "2010305B15Rik, AW321064, Actr, Aib1, KAT13B, Rac3, Src3, Tram-1, Tram1, bHLHe42, p/Cip, pCip " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004729 1797 DXO http://www.ncbi.nlm.nih.gov/gene/?term=1797 "DOM3L, DOM3Z, NG6, RAI1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004730 1798 DPAGT1 http://www.ncbi.nlm.nih.gov/gene/?term=1798 "ALG7, CDG-Ij, CDG1J, CMS13, CMSTA2, D11S366, DGPT, DPAGT, DPAGT2, G1PT, GPT, UAGT, UGAT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004731 1798 DPAGT1 http://www.ncbi.nlm.nih.gov/gene/?term=1798 "ALG7, CDG-Ij, CDG1J, CMS13, CMSTA2, D11S366, DGPT, DPAGT, DPAGT2, G1PT, GPT, UAGT, UGAT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004732 17996 Neb http://www.ncbi.nlm.nih.gov/gene/?term=17996 AI595938 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004733 17997 Nedd1 http://www.ncbi.nlm.nih.gov/gene/?term=17997 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004734 18004 Nek1 http://www.ncbi.nlm.nih.gov/gene/?term=18004 "D8Ertd790e, kat " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004735 18007 Neo1 http://www.ncbi.nlm.nih.gov/gene/?term=18007 "2610028H22Rik, AI327052, D930014N22Rik, Igdcc2 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004736 18007 Neo1 http://www.ncbi.nlm.nih.gov/gene/?term=18007 "2610028H22Rik, AI327052, D930014N22Rik, Igdcc2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004737 1800 DPEP1 http://www.ncbi.nlm.nih.gov/gene/?term=1800 "MBD1, MDP, RDP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004738 18012 Neurod1 http://www.ncbi.nlm.nih.gov/gene/?term=18012 "BETA2, BHF-1, Neurod, bHLHa3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004739 18012 Neurod1 http://www.ncbi.nlm.nih.gov/gene/?term=18012 "BETA2, BHF-1, Neurod, bHLHa3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004740 18013 Neurod2 http://www.ncbi.nlm.nih.gov/gene/?term=18013 "Ndrf, bHLHa1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004741 18015 Nf1 http://www.ncbi.nlm.nih.gov/gene/?term=18015 "AW494271, Dsk9, E030030H24Rik, Mhdadsk9, Nf-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004742 18018 Nfatc1 http://www.ncbi.nlm.nih.gov/gene/?term=18018 "2210017P03Rik, AI449492, AV076380, NF-ATc, NFAT2, NFATc, Nfatcb " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004743 1801 DPH1 http://www.ncbi.nlm.nih.gov/gene/?term=1801 "DPH2L, DPH2L1, OVCA1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004744 1801 DPH1 http://www.ncbi.nlm.nih.gov/gene/?term=1801 "DPH2L, DPH2L1, OVCA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004745 1801 DPH1 http://www.ncbi.nlm.nih.gov/gene/?term=1801 "DPH2L, DPH2L1, OVCA1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004746 18020 Nfatc2ip http://www.ncbi.nlm.nih.gov/gene/?term=18020 "D7Ertd304e, NIP45 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004747 18021 Nfatc3 http://www.ncbi.nlm.nih.gov/gene/?term=18021 "C80703, D8Ertd281e, NFAT4, NFATx " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004748 18028 Nfib http://www.ncbi.nlm.nih.gov/gene/?term=18028 "6720429L07Rik, CTF, E030026I10Rik, NF-I/B, NF1-B, NFI-B " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004749 18030 Nfil3 http://www.ncbi.nlm.nih.gov/gene/?term=18030 "AV225605, E4BP4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004750 18035 Nfkbia http://www.ncbi.nlm.nih.gov/gene/?term=18035 "AI462015, Nfkbi " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004751 18036 Nfkbib http://www.ncbi.nlm.nih.gov/gene/?term=18036 "I(Kappa)B(beta), I-kappa-B-beta, IKB-beta, IKappaBbeta, IkB, IkBb, NF-kappa-BIB, ikB-B " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004752 18038 Nfkbil1 http://www.ncbi.nlm.nih.gov/gene/?term=18038 "Def-7, IKBL " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004753 18045 Nfyb http://www.ncbi.nlm.nih.gov/gene/?term=18045 "AA985999, Cbf-A " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004754 18046 Nfyc http://www.ncbi.nlm.nih.gov/gene/?term=18046 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004755 1804 DPP6 http://www.ncbi.nlm.nih.gov/gene/?term=1804 "DPL1, DPPX, MRD33, VF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004756 18072 Nhlh2 http://www.ncbi.nlm.nih.gov/gene/?term=18072 "6230401I09Rik, Hen2, NSCL2, Nscl-2, bHLHa34 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004757 18080 Nin http://www.ncbi.nlm.nih.gov/gene/?term=18080 "3110068G20Rik, AI385615, AU024711, mKIAA1565 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004758 18081 Ninj1 http://www.ncbi.nlm.nih.gov/gene/?term=18081 AU024536 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004759 18087 Nktr http://www.ncbi.nlm.nih.gov/gene/?term=18087 "5330401F18Rik, D9Wsu172e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004760 1808 DPYSL2 http://www.ncbi.nlm.nih.gov/gene/?term=1808 "CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004761 18091 Nkx2-5 http://www.ncbi.nlm.nih.gov/gene/?term=18091 "Csx, Nkx-2.5, Nkx2.5, tinman " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004762 18099 Nlk http://www.ncbi.nlm.nih.gov/gene/?term=18099 AI194375 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004763 18101 Nmbr http://www.ncbi.nlm.nih.gov/gene/?term=18101 BB182387 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004764 18103 Nme2 http://www.ncbi.nlm.nih.gov/gene/?term=18103 "NM23-H2, NM23B, nm23-M2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004765 18103 Nme2 http://www.ncbi.nlm.nih.gov/gene/?term=18103 "NM23-H2, NM23B, nm23-M2 " mRNA Mus musculus 11891645 Nucleus Dorsal root ganglia In situ hybridization "Moreover, in situ hybridization also displayed a specific nuclear localization for nm23-M2 mRNA. " RLID00004766 18108 Nmt2 http://www.ncbi.nlm.nih.gov/gene/?term=18108 "A930001K02Rik, AI605445, AU044698, hNMT-2 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004767 18109 Mycn http://www.ncbi.nlm.nih.gov/gene/?term=18109 "N-myc, Nmyc, Nmyc-1, Nmyc1, bHLHe37, c-nmyc " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004768 1810 DR1 http://www.ncbi.nlm.nih.gov/gene/?term=1810 "NC2, NC2-BETA, NC2B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004769 1810 DR1 http://www.ncbi.nlm.nih.gov/gene/?term=1810 "NC2, NC2-BETA, NC2B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004770 18113 Nnmt http://www.ncbi.nlm.nih.gov/gene/?term=18113 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004771 18115 Nnt http://www.ncbi.nlm.nih.gov/gene/?term=18115 "4930423F13Rik, AI323702, BB168308 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004772 18117 Emc8 http://www.ncbi.nlm.nih.gov/gene/?term=18117 "Cox4nb, Fam158b, Noc4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004773 18128 Notch1 http://www.ncbi.nlm.nih.gov/gene/?term=18128 "9930111A19Rik, Mis6, N1, Tan1, lin-12 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00004774 18130 Ints6 http://www.ncbi.nlm.nih.gov/gene/?term=18130 "2900075H24Rik, AI480962, DICE1, Ddx26, HDB, Notch2l " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004775 18139 Zfp638 http://www.ncbi.nlm.nih.gov/gene/?term=18139 "AI323587, Np220, Zfml, Znf638, mNP220 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004776 1813 DRD2 http://www.ncbi.nlm.nih.gov/gene/?term=1813 "D2DR, D2R " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004777 18140 Uhrf1 http://www.ncbi.nlm.nih.gov/gene/?term=18140 "AL022808, ICBP90, Np95, RNF106 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004778 18141 Nup50 http://www.ncbi.nlm.nih.gov/gene/?term=18141 "1700030K07Rik, AI413123, Npap60 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004779 18142 Npas1 http://www.ncbi.nlm.nih.gov/gene/?term=18142 "MOP5, bHLHe11 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004780 18145 Npc1 http://www.ncbi.nlm.nih.gov/gene/?term=18145 "A430089E03Rik, C85354, D18Ertd139e, D18Ertd723e, lcsd, nmf164, spm " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004781 18148 Npm1 http://www.ncbi.nlm.nih.gov/gene/?term=18148 "B23, NO38, Npm " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004782 18148 Npm1 http://www.ncbi.nlm.nih.gov/gene/?term=18148 "B23, NO38, Npm " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00004783 18162 Npr3 http://www.ncbi.nlm.nih.gov/gene/?term=18162 "ANP-C, ANPR-C, EF-2, NPR-C, lgj, stri " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004784 18173 Slc11a1 http://www.ncbi.nlm.nih.gov/gene/?term=18173 "Bcg, Ity, Ity1, Lsh, Nramp, Nramp1, ity " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004785 18175 Nrap http://www.ncbi.nlm.nih.gov/gene/?term=18175 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004786 18181 Nrf1 http://www.ncbi.nlm.nih.gov/gene/?term=18181 "C87038, D6Ertd415e " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004787 18186 Nrp1 http://www.ncbi.nlm.nih.gov/gene/?term=18186 "C530029I03, NP-1, NPN-1, Npn1, Nrp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004788 18187 Nrp2 http://www.ncbi.nlm.nih.gov/gene/?term=18187 "1110048P06Rik, Np-2, Np2, Npn-2, Npn2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004789 18190 Nrxn2 http://www.ncbi.nlm.nih.gov/gene/?term=18190 "6430591O13Rik, mKIAA0921 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004790 18191 Nrxn3 http://www.ncbi.nlm.nih.gov/gene/?term=18191 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004791 18197 Nsg2 http://www.ncbi.nlm.nih.gov/gene/?term=18197 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004792 1819 DRG2 http://www.ncbi.nlm.nih.gov/gene/?term=1819 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004793 1819 DRG2 http://www.ncbi.nlm.nih.gov/gene/?term=1819 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004794 1819 DRG2 http://www.ncbi.nlm.nih.gov/gene/?term=1819 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004795 18201 Nsmaf http://www.ncbi.nlm.nih.gov/gene/?term=18201 "AA959567, C630007J05, Fan " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004796 18207 Nthl1 http://www.ncbi.nlm.nih.gov/gene/?term=18207 "Nth1, Octs3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004797 1820 ARID3A http://www.ncbi.nlm.nih.gov/gene/?term=1820 "BRIGHT, DRIL1, DRIL3, E2FBP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004798 18213 Ntrk3 http://www.ncbi.nlm.nih.gov/gene/?term=18213 "AW125844_tv3, TrkC, Ntrk3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004799 18214 Ddr2 http://www.ncbi.nlm.nih.gov/gene/?term=18214 "AW495251, Ntrkr3, tyro10 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004800 18214 Ddr2 http://www.ncbi.nlm.nih.gov/gene/?term=18214 "AW495251, Ntrkr3, tyro10 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004801 18214 Ddr2 http://www.ncbi.nlm.nih.gov/gene/?term=18214 "AW495251, Ntrkr3, tyro10 " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00004802 18217 Ntsr2 http://www.ncbi.nlm.nih.gov/gene/?term=18217 "NT2R, NTRL " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004803 1822 ATN1 http://www.ncbi.nlm.nih.gov/gene/?term=1822 "B37, D12S755E, DRPLA, HRS, NOD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004804 18230 Nxn http://www.ncbi.nlm.nih.gov/gene/?term=18230 l11Jus13 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004805 18247 Oaz2 http://www.ncbi.nlm.nih.gov/gene/?term=18247 "AZ-2, AZ2-ps, Sez15, Oaz2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004806 1824 DSC2 http://www.ncbi.nlm.nih.gov/gene/?term=1824 "ARVD11, CDHF2, DG2, DGII/III, DSC3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004807 1824 DSC2 http://www.ncbi.nlm.nih.gov/gene/?term=1824 "ARVD11, CDHF2, DG2, DGII/III, DSC3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004808 1825 DSC3 http://www.ncbi.nlm.nih.gov/gene/?term=1825 "CDHF3, DSC, DSC1, DSC2, DSC4, HT-CP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004809 1825 DSC3 http://www.ncbi.nlm.nih.gov/gene/?term=1825 "CDHF3, DSC, DSC1, DSC2, DSC4, HT-CP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004810 18263 Odc1 http://www.ncbi.nlm.nih.gov/gene/?term=18263 ODC mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004811 1826 DSCAM http://www.ncbi.nlm.nih.gov/gene/?term=1826 "CHD2, CHD2-42, CHD2-52 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004812 1827 RCAN1 http://www.ncbi.nlm.nih.gov/gene/?term=1827 "ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004813 1827 RCAN1 http://www.ncbi.nlm.nih.gov/gene/?term=1827 "ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004814 1827 RCAN1 http://www.ncbi.nlm.nih.gov/gene/?term=1827 "ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004815 18292 Sebox http://www.ncbi.nlm.nih.gov/gene/?term=18292 "OG9, Og9x " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004816 1829 DSG2 http://www.ncbi.nlm.nih.gov/gene/?term=1829 "CDHF5, HDGC " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004817 1829 DSG2 http://www.ncbi.nlm.nih.gov/gene/?term=1829 "CDHF5, HDGC " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004818 182 JAG1 http://www.ncbi.nlm.nih.gov/gene/?term=182 "AGS, AHD, AWS, CD339, HJ1, JAGL1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004819 182 JAG1 http://www.ncbi.nlm.nih.gov/gene/?term=182 "AGS, AHD, AWS, CD339, HJ1, JAGL1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004820 1830 DSG3 http://www.ncbi.nlm.nih.gov/gene/?term=1830 "CDHF6, PVA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004821 1830 DSG3 http://www.ncbi.nlm.nih.gov/gene/?term=1830 "CDHF6, PVA " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004822 18312 Olfr15 http://www.ncbi.nlm.nih.gov/gene/?term=18312 "MOR256-17, OR3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004823 1831 TSC22D3 http://www.ncbi.nlm.nih.gov/gene/?term=1831 "DIP, DSIPI, GILZ, TSC-22R " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004824 1832 DSP http://www.ncbi.nlm.nih.gov/gene/?term=1832 "DCWHKTA, DP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004825 18356 Olfr56 http://www.ncbi.nlm.nih.gov/gene/?term=18356 "IF7, MOR276-1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004826 18363 Olfr62 http://www.ncbi.nlm.nih.gov/gene/?term=18363 "H12, IH12, MOR258-5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004827 1836 SLC26A2 http://www.ncbi.nlm.nih.gov/gene/?term=1836 "D5S1708, DTD, DTDST, EDM4, MST153, MSTP157 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004828 1836 SLC26A2 http://www.ncbi.nlm.nih.gov/gene/?term=1836 "D5S1708, DTD, DTDST, EDM4, MST153, MSTP157 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004829 18377 Omg http://www.ncbi.nlm.nih.gov/gene/?term=18377 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004830 1838 DTNB http://www.ncbi.nlm.nih.gov/gene/?term=1838 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004831 18392 Orc1 http://www.ncbi.nlm.nih.gov/gene/?term=18392 "AA545195, MmORC1l, Orc1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004832 1839 HBEGF http://www.ncbi.nlm.nih.gov/gene/?term=1839 "DTR, DTS, DTSF, HEGFL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004833 1840 DTX1 http://www.ncbi.nlm.nih.gov/gene/?term=1840 hDx-1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004834 18412 Sqstm1 http://www.ncbi.nlm.nih.gov/gene/?term=18412 "A170, OSF-6, Osi, STAP, STONE14, p62 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004835 18415 Hspa4l http://www.ncbi.nlm.nih.gov/gene/?term=18415 "94kDa, AI461691, APG-1, Osp94 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004836 1841 DTYMK http://www.ncbi.nlm.nih.gov/gene/?term=1841 "CDC8, PP3731, TMPK, TYMK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004837 1841 DTYMK http://www.ncbi.nlm.nih.gov/gene/?term=1841 "CDC8, PP3731, TMPK, TYMK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004838 1842 ECM2 http://www.ncbi.nlm.nih.gov/gene/?term=1842 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004839 18439 P2rx7 http://www.ncbi.nlm.nih.gov/gene/?term=18439 "AI467586, P2X(7), P2X7R " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004840 1843 DUSP1 http://www.ncbi.nlm.nih.gov/gene/?term=1843 "CL100, HVH1, MKP-1, MKP1, PTPN10 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004841 18451 P4ha1 http://www.ncbi.nlm.nih.gov/gene/?term=18451 "AL022634, P4ha " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004842 18458 Pabpc1 http://www.ncbi.nlm.nih.gov/gene/?term=18458 "PABP, Pabp1, PabpI, Pabpl1, ePAB " mRNA Mus musculus 25370180 Cytoplasm Oocyte In situ hybridization "However, Pabpc1 transcript was highly generated in the prepubertal and pubertal mouse ovaries except for 1-week old ovary than those of other developmental terms. In the prepubertal mouse ovaries, RNA in situ hybridization localized both Epab and Pabpc1 transcripts in the cytoplasm of oocytes and granulosa cells of all follicular stages. " RLID00004843 1845 DUSP3 http://www.ncbi.nlm.nih.gov/gene/?term=1845 VHR mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004844 1845 DUSP3 http://www.ncbi.nlm.nih.gov/gene/?term=1845 VHR mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004845 18472 Pafah1b1 http://www.ncbi.nlm.nih.gov/gene/?term=18472 "LIS-1, Lis1, MMS10-U, Mdsh, Ms10u, Pafaha " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004846 18475 Pafah1b2 http://www.ncbi.nlm.nih.gov/gene/?term=18475 "AI747451, AU021353, Pafahb, mus[b] " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004847 18477 Prdx1 http://www.ncbi.nlm.nih.gov/gene/?term=18477 "MSP23, NkefA, OSF-3, OSF3, PAG, Paga, PrdxI, PrxI, TDX2, TPxA, Tdpx2, prx1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004848 1847 DUSP5 http://www.ncbi.nlm.nih.gov/gene/?term=1847 "DUSP, HVH3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004849 1847 DUSP5 http://www.ncbi.nlm.nih.gov/gene/?term=1847 "DUSP, HVH3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004850 1847 DUSP5 http://www.ncbi.nlm.nih.gov/gene/?term=1847 "DUSP, HVH3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004851 18491 Pappa http://www.ncbi.nlm.nih.gov/gene/?term=18491 "8430414N03Rik, IGFBP-4ase, PAG1, PAPP-A " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004852 1849 DUSP7 http://www.ncbi.nlm.nih.gov/gene/?term=1849 "MKPX, PYST2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004853 1849 DUSP7 http://www.ncbi.nlm.nih.gov/gene/?term=1849 "MKPX, PYST2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004854 1849 DUSP7 http://www.ncbi.nlm.nih.gov/gene/?term=1849 "MKPX, PYST2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004855 18510 Pax8 http://www.ncbi.nlm.nih.gov/gene/?term=18510 Pax-8 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004856 18514 Pbx1 http://www.ncbi.nlm.nih.gov/gene/?term=18514 "2310056B04Rik, D230003C07Rik, Pbx-1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004857 18516 Pbx3 http://www.ncbi.nlm.nih.gov/gene/?term=18516 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004858 18519 Kat2b http://www.ncbi.nlm.nih.gov/gene/?term=18519 "A930006P13Rik, AI461839, AW536563, Pcaf, p/CAF " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004859 18536 Pcm1 http://www.ncbi.nlm.nih.gov/gene/?term=18536 "2600002H09Rik, 9430077F19Rik, C030044G17Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004860 18541 Pcnt http://www.ncbi.nlm.nih.gov/gene/?term=18541 "AW476095, C86676, KEN2, kendrin, m239Asp, m275Asp, Pcnt " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004861 18545 Pcp2 http://www.ncbi.nlm.nih.gov/gene/?term=18545 "L7, Pcp-2 " mRNA Mus musculus 9387927 Dendrite Purkinje cell In situ hybridizationq|Immunocytochemistry "L7 mRNA is localized in clusters within the proximal and distal branches of dendrites, but also in the proximal part of Purkinje cell axons. " RLID00004862 18545 Pcp2 http://www.ncbi.nlm.nih.gov/gene/?term=18545 "L7, Pcp-2 " mRNA Mus musculus 9387927 Axon Purkinje cell In situ hybridizationq|Immunocytochemistry "L7 mRNA is localized in clusters within the proximal and distal branches of dendrites, but also in the proximal part of Purkinje cell axons. " RLID00004863 18545 Pcp2 http://www.ncbi.nlm.nih.gov/gene/?term=18545 "L7, Pcp-2 " mRNA Mus musculus 12399102 Cell body Purkinje cell In situ hybridization In mouse both mRNA forms are detectable in dendrites but their relative proportions change during development. In order to determine the subcellular distribution of the two forms of L7 mRNA we performed in situ hybridization using exon 1A- and 1B-specific probes. Both mRNA forms were found to be abundantly localized in both the cell body and dendrites of Purkinje cells (Fig. 2). RLID00004864 18545 Pcp2 http://www.ncbi.nlm.nih.gov/gene/?term=18545 "L7, Pcp-2 " mRNA Mus musculus 12399102 Dendrite Purkinje cell In situ hybridization In mouse both mRNA forms are detectable in dendrites but their relative proportions change during development. In order to determine the subcellular distribution of the two forms of L7 mRNA we performed in situ hybridization using exon 1A- and 1B-specific probes. Both mRNA forms were found to be abundantly localized in both the cell body and dendrites of Purkinje cells (Fig. 2). RLID00004865 18549 Pcsk2 http://www.ncbi.nlm.nih.gov/gene/?term=18549 "6330411F23Rik, AI839700, Nec-2, Nec2, PC2, Phpp-2, SPC2 " mRNA Mus musculus 15972000 Endoplasmic reticulum MIN6 cell Northern blot "Figure 2: Glucose stimulates the recruitment of mRNAs encoding secretory membrane proteins to the ER: subcellular fractionation using the digitonin method. MIN6 cells were preincubated in KRB containing 2 mM glucose for 1 h followed by incubation in KRB containing 2 or 20 mM glucose for a further period of 1 h. (a) Cells were permeabilized with digitonin and pelleted resulting in a membrane fraction (Mem) and a cytosolic fraction (Cyt). The 10% refers to 10% of total RNA/protein. RNA was isolated from each fraction and run on a 1% agarose formaldehyde gel, transferred on to a nylon membrane and probed for proinsulin (PI), PC2, CPH and actin mRNAs. The intensities of the bands were quantified using ImageJ and the mRNA levels were expressed as a percentage of total mRNA. (b) Protein samples from each fraction were run on SDS/PAGE (20% of membrane fraction and 20% of cytosolic fraction) and subjected to immunoblotting with anti-ERK2, calreticulin and SRP54 antibodies. Detection was by enhanced chemiluminescence. The results presented are representative of three separate experiments. Data are collected from Figure 2. " RLID00004866 1854 DUT http://www.ncbi.nlm.nih.gov/gene/?term=1854 dUTPase mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004867 1854 DUT http://www.ncbi.nlm.nih.gov/gene/?term=1854 dUTPase mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004868 1855 DVL1 http://www.ncbi.nlm.nih.gov/gene/?term=1855 "DRS2, DVLL1, DVL1P1, DVL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004869 18563 Pcx http://www.ncbi.nlm.nih.gov/gene/?term=18563 "Pc, Pcb " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004870 18569 Pdcd4 http://www.ncbi.nlm.nih.gov/gene/?term=18569 "D19Ucla1, Ma3, Tis " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004871 1856 DVL2 http://www.ncbi.nlm.nih.gov/gene/?term=1856 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004872 1856 DVL2 http://www.ncbi.nlm.nih.gov/gene/?term=1856 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004873 18572 Pdcd11 http://www.ncbi.nlm.nih.gov/gene/?term=18572 "1110021I22Rik, ALG-4, Pdcd7, mKIAA0185 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004874 18576 Pde3b http://www.ncbi.nlm.nih.gov/gene/?term=18576 "9830102A01Rik, AI847709 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004875 18577 Pde4a http://www.ncbi.nlm.nih.gov/gene/?term=18577 "D9Ertd60e, Dpde2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004876 18578 Pde4b http://www.ncbi.nlm.nih.gov/gene/?term=18578 "Dpde4, R74983, dunce " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004877 1857 DVL3 http://www.ncbi.nlm.nih.gov/gene/?term=1857 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004878 1857 DVL3 http://www.ncbi.nlm.nih.gov/gene/?term=1857 DRS3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004879 18583 Pde7a http://www.ncbi.nlm.nih.gov/gene/?term=18583 "AU015378, AW047537 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004880 18595 Pdgfra http://www.ncbi.nlm.nih.gov/gene/?term=18595 "AI115593, CD140a, Pdgfr-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004881 18597 Pdha1 http://www.ncbi.nlm.nih.gov/gene/?term=18597 Pdha-1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004882 1859 DYRK1A http://www.ncbi.nlm.nih.gov/gene/?term=1859 "DYRK, DYRK1, HP86, MNB, MNBH, MRD7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004883 1859 DYRK1A http://www.ncbi.nlm.nih.gov/gene/?term=1859 "DYRK, DYRK1, HP86, MNB, MNBH, MRD7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004884 185 AGTR1 http://www.ncbi.nlm.nih.gov/gene/?term=185 "AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004885 18605 Enpp1 http://www.ncbi.nlm.nih.gov/gene/?term=18605 "4833416E15Rik, AI428932, C76301, CD203c, E-NPP 1, E-NPP1, Ly-41, M6S1, NPP1, Npps, PC-1, Pca, Pca-1, Pdnp1, ttw, twy " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004886 18607 Pdpk1 http://www.ncbi.nlm.nih.gov/gene/?term=18607 Pdk1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004887 18610 Pdyn http://www.ncbi.nlm.nih.gov/gene/?term=18610 Dyn mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004888 18613 Pecam1 http://www.ncbi.nlm.nih.gov/gene/?term=18613 "C85791, Cd31, PECAM-1, Pecam " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004889 18616 Peg3 http://www.ncbi.nlm.nih.gov/gene/?term=18616 "AL022617, ASF-1, End4, Gcap4, Pw1, Zfp102, mKIAA0287 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004890 18618 Pemt http://www.ncbi.nlm.nih.gov/gene/?term=18618 "PEAMT, PEMT2, Pempt, Pempt2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004891 1861 TOR1A http://www.ncbi.nlm.nih.gov/gene/?term=1861 "DQ2, DYT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004892 1861 TOR1A http://www.ncbi.nlm.nih.gov/gene/?term=1861 "DQ2, DYT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004893 1861 TOR1A http://www.ncbi.nlm.nih.gov/gene/?term=1861 "DQ2, DYT1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004894 18628 Per3 http://www.ncbi.nlm.nih.gov/gene/?term=18628 "2810049O06Rik, mPer3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004895 18628 Per3 http://www.ncbi.nlm.nih.gov/gene/?term=18628 "2810049O06Rik, mPer3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004896 18633 Pex16 http://www.ncbi.nlm.nih.gov/gene/?term=18633 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004897 18636 Cfp http://www.ncbi.nlm.nih.gov/gene/?term=18636 "BCFG, Pfc " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004898 18639 Pfkfb1 http://www.ncbi.nlm.nih.gov/gene/?term=18639 PFK/FBPase 1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004899 18640 Pfkfb2 http://www.ncbi.nlm.nih.gov/gene/?term=18640 4930568D07Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004900 18641 Pfkl http://www.ncbi.nlm.nih.gov/gene/?term=18641 "AA407869, ATP-PFK, PFK-L " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004901 18645 Pfn2 http://www.ncbi.nlm.nih.gov/gene/?term=18645 Pfn mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004902 18655 Pgk1 http://www.ncbi.nlm.nih.gov/gene/?term=18655 Pgk-1 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00004903 18669 Abcb1b http://www.ncbi.nlm.nih.gov/gene/?term=18669 "Abcb1, Mdr1, Mdr1b, Pgy-1, Pgy1, mdr " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004904 18674 Slc25a3 http://www.ncbi.nlm.nih.gov/gene/?term=18674 "5730556H19Rik, PTP, Phc " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004905 18685 Phtf1 http://www.ncbi.nlm.nih.gov/gene/?term=18685 "AU041898, AW049785, Phft, Phtf " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004906 1869 E2F1 http://www.ncbi.nlm.nih.gov/gene/?term=1869 "E2F-1, RBAP1, RBBP3, RBP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004907 1869 E2F1 http://www.ncbi.nlm.nih.gov/gene/?term=1869 "E2F-1, RBAP1, RBBP3, RBP3 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004908 1869 E2F1 http://www.ncbi.nlm.nih.gov/gene/?term=1869 "E2F-1, RBAP1, RBBP3, RBP3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004909 18700 Piga http://www.ncbi.nlm.nih.gov/gene/?term=18700 "AI194334, Pig-a " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004910 18701 Pigf http://www.ncbi.nlm.nih.gov/gene/?term=18701 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004911 18704 Pik3c2a http://www.ncbi.nlm.nih.gov/gene/?term=18704 "Cpk-m, PI3KC2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004912 18706 Pik3ca http://www.ncbi.nlm.nih.gov/gene/?term=18706 "6330412C24Rik, caPI3K, p110, p110alpha " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004913 18708 Pik3r1 http://www.ncbi.nlm.nih.gov/gene/?term=18708 "PI3K, p50alpha, p55alpha, p85alpha " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004914 18709 Pik3r2 http://www.ncbi.nlm.nih.gov/gene/?term=18709 p85beta mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004915 1870 E2F2 http://www.ncbi.nlm.nih.gov/gene/?term=1870 E2F-2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004916 1870 E2F2 http://www.ncbi.nlm.nih.gov/gene/?term=1870 E2F-2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004917 1870 E2F2 http://www.ncbi.nlm.nih.gov/gene/?term=1870 E2F-2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004918 1870 E2F2 http://www.ncbi.nlm.nih.gov/gene/?term=1870 E2F-2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004919 18712 Pim1 http://www.ncbi.nlm.nih.gov/gene/?term=18712 Pim-1 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00004920 18718 Pip4k2a http://www.ncbi.nlm.nih.gov/gene/?term=18718 "AW742916, Pip5k2a " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004921 1871 E2F3 http://www.ncbi.nlm.nih.gov/gene/?term=1871 E2F-3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004922 18741 Pitx2 http://www.ncbi.nlm.nih.gov/gene/?term=18741 "9430085M16Rik, Brx1, Brx1b, Munc30, Otlx2, Ptx2, Rieg " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004923 18747 Prkaca http://www.ncbi.nlm.nih.gov/gene/?term=18747 "PKCD, Pkaca " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004924 1874 E2F4 http://www.ncbi.nlm.nih.gov/gene/?term=1874 E2F-4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004925 1874 E2F4 http://www.ncbi.nlm.nih.gov/gene/?term=1874 E2F-4 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004926 18750 Prkca http://www.ncbi.nlm.nih.gov/gene/?term=18750 "AI875142, Pkca " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004927 18754 Prkce http://www.ncbi.nlm.nih.gov/gene/?term=18754 "5830406C15Rik, PKC[e], PKCepsilon, Pkce, R75156 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004928 1875 E2F5 http://www.ncbi.nlm.nih.gov/gene/?term=1875 E2F-5 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004929 1875 E2F5 http://www.ncbi.nlm.nih.gov/gene/?term=1875 E2F-5 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00004930 18762 Prkcz http://www.ncbi.nlm.nih.gov/gene/?term=18762 "AI098070, C80388, Pkcz, R74924, aPKCzeta, nPKC-zeta, zetaPKC " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004931 18763 Pkd1 http://www.ncbi.nlm.nih.gov/gene/?term=18763 "PC1, mFLJ00285 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004932 18764 Pkd2 http://www.ncbi.nlm.nih.gov/gene/?term=18764 "C030034P18Rik, PC2, TRPP2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004933 18786 Plaa http://www.ncbi.nlm.nih.gov/gene/?term=18786 "2410007N06, AI536418, AU018445, AW208417, D4Ertd618e, PLA2P, PLAP, Ufd3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004934 18789 Papola http://www.ncbi.nlm.nih.gov/gene/?term=18789 "Pap, PapIII, Plap " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004935 18791 Plat http://www.ncbi.nlm.nih.gov/gene/?term=18791 "AU020998, AW212668, D8Ertd2e, tPA " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004936 18798 Plcb4 http://www.ncbi.nlm.nih.gov/gene/?term=18798 "A930039J07Rik, AI854601, C230058B11Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004937 18805 Pld1 http://www.ncbi.nlm.nih.gov/gene/?term=18805 "AA536939, C85393a, Pld1b, Pld1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004938 18810 Plec http://www.ncbi.nlm.nih.gov/gene/?term=18810 "AA591047, AU042537, EBS1, PCN, PLTN1, Plec " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004939 18817 Plk1 http://www.ncbi.nlm.nih.gov/gene/?term=18817 "Plk, STPK13 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004940 18823 Plp1 http://www.ncbi.nlm.nih.gov/gene/?term=18823 "DM20, Plp, jimpy, jp, msd, rsh " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004941 18823 Plp1 http://www.ncbi.nlm.nih.gov/gene/?term=18823 "DM20, Plp, jimpy, jp, msd, rsh " mRNA Mus musculus 7877439 Cytoplasm Brain In situ hybridization A similar staining pattern was evident in sections hybridized with CNP riboprobe (Fig. 4C) suggesting that the distribution of both CNP and PLP mRNA was primarily perinuclear. RLID00004942 18845 Plxna2 http://www.ncbi.nlm.nih.gov/gene/?term=18845 "2810428A13Rik, AA589422, AW457381, OCT, PlexA2, Plxn2, mKIAA0463 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004943 18854 Pml http://www.ncbi.nlm.nih.gov/gene/?term=18854 "1200009E24Rik, AI661194, Trim19 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004944 18857 Pmp2 http://www.ncbi.nlm.nih.gov/gene/?term=18857 P2 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004945 18861 Pms2 http://www.ncbi.nlm.nih.gov/gene/?term=18861 "AW555130, Pmsl2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004946 1889 ECE1 http://www.ncbi.nlm.nih.gov/gene/?term=1889 ECE mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004947 1891 ECH1 http://www.ncbi.nlm.nih.gov/gene/?term=1891 HPXEL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004948 1891 ECH1 http://www.ncbi.nlm.nih.gov/gene/?term=1891 HPXEL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004949 1892 ECHS1 http://www.ncbi.nlm.nih.gov/gene/?term=1892 "ECHS1D, SCEH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004950 1892 ECHS1 http://www.ncbi.nlm.nih.gov/gene/?term=1892 "ECHS1D, SCEH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004951 1893 ECM1 http://www.ncbi.nlm.nih.gov/gene/?term=1893 URBWD mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004952 18949 Pnn http://www.ncbi.nlm.nih.gov/gene/?term=18949 "AU045199, D12Ertd512e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004953 1894 ECT2 http://www.ncbi.nlm.nih.gov/gene/?term=1894 ARHGEF31 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004954 18968 Pola1 http://www.ncbi.nlm.nih.gov/gene/?term=18968 "AW321876, Pola " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004955 18972 Pold2 http://www.ncbi.nlm.nih.gov/gene/?term=18972 "50kDa, p50, po1D2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004956 18973 Pole http://www.ncbi.nlm.nih.gov/gene/?term=18973 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004957 18974 Pole2 http://www.ncbi.nlm.nih.gov/gene/?term=18974 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004958 18983 Cnot7 http://www.ncbi.nlm.nih.gov/gene/?term=18983 "AU022737, CAF-1, Caf1, Pop2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004959 18986 Pou2f1 http://www.ncbi.nlm.nih.gov/gene/?term=18986 "2810482H01Rik, NF-A1, Oct-1, Oct1, Otf-1, Otf1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004960 18988 Pou2f3 http://www.ncbi.nlm.nih.gov/gene/?term=18988 "Epoc-1, Oct-11a, Oct11, Otf-11, Otf11, Skin, Skin-1a, Skn-1a, Skn-li " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004961 18996 Pou4f1 http://www.ncbi.nlm.nih.gov/gene/?term=18996 "Brn-3, Brn-3.0, Brn3, Brn3.0, Brn3a, E130119J07Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004962 18998 Pou4f3 http://www.ncbi.nlm.nih.gov/gene/?term=18998 "Brn3.1, Brn3c, ddl, dreidel " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004963 189 AGXT http://www.ncbi.nlm.nih.gov/gene/?term=189 "AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004964 19014 Med1 http://www.ncbi.nlm.nih.gov/gene/?term=19014 "AI480703, CRSP210, DRIP205, PBP, Pparbp, TRAP220, l11Jus15 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004965 19015 Ppard http://www.ncbi.nlm.nih.gov/gene/?term=19015 "NUC-1, NUC1, Nr1c2, PPAR-beta, PPAR-delta, PPAR[b], PPARdelta, Pparb, Pparb/d " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004966 19017 Ppargc1a http://www.ncbi.nlm.nih.gov/gene/?term=19017 "A830037N07Rik, ENSMUSG00000079510, Gm11133, PGC-1, PPARGC-1-alpha, Pgc-1alpha, Pgc1, Pgco1, Ppargc1 " mRNA Mus musculus 12234291 Nucleus LLCPK1 cell In situ hybridization|qRT-PCR "PGC-1 was localized to the nuclei. At low levels of expression, nuclear staining was diffuse. At higher levels of expression, GFP-PGC-1 localized to nuclear speckles. " RLID00004967 1901 S1PR1 http://www.ncbi.nlm.nih.gov/gene/?term=1901 "CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004968 19024 Ppfibp2 http://www.ncbi.nlm.nih.gov/gene/?term=19024 Cclp1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004969 19027 Sypl http://www.ncbi.nlm.nih.gov/gene/?term=19027 "AI314763, AI604763, D12Ertd446e, PanI, Pphn1, Sypl " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004970 19027 Sypl http://www.ncbi.nlm.nih.gov/gene/?term=19027 "AI314763, AI604763, D12Ertd446e, PanI, Pphn1, Sypl " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004971 19045 Ppp1ca http://www.ncbi.nlm.nih.gov/gene/?term=19045 "Ppp1c, dism2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004972 19047 Ppp1cc http://www.ncbi.nlm.nih.gov/gene/?term=19047 "PP-1G, PP1, dis2m1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004973 19053 Ppp2cb http://www.ncbi.nlm.nih.gov/gene/?term=19053 "AI115466, D8Ertd766e, PP2Ac " mRNA Mus musculus 18539120 Synapse Brain qRT-PCR "The mRNA targets reduced in Kif5 association included genes involved in actin remodeling at synapses (cofilin phosphatase (PP2Ac); p116-RIP), synapse-associated signaling (DAG1;RGS5) and synapse structure (SAPAP4; CaMKIIa; MAP1b). Not all mRNAs were significantly reduced in Kif5 IPs, as OCRL1 mRNA was similar in KO brain (P>0.05, n=8). " RLID00004974 19056 Ppp3cb http://www.ncbi.nlm.nih.gov/gene/?term=19056 "1110063J16Rik, Calnb, CnAbeta, Cnab " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004975 19058 Ppp3r1 http://www.ncbi.nlm.nih.gov/gene/?term=19058 "CaNB1, Cnb1, MCIP1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004976 19063 Ppt1 http://www.ncbi.nlm.nih.gov/gene/?term=19063 "9530043G02Rik, AA960502, C77813, CLN1, D4Ertd184e, INCL, PPT " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004977 19069 Nup88 http://www.ncbi.nlm.nih.gov/gene/?term=19069 "Nup84, Prei2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004978 19070 Mob4 http://www.ncbi.nlm.nih.gov/gene/?term=19070 "2610109B12Rik, Mobkl3, Phocn, Prei3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004979 19075 Prim1 http://www.ncbi.nlm.nih.gov/gene/?term=19075 AI324982 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004980 19084 Prkar1a http://www.ncbi.nlm.nih.gov/gene/?term=19084 "1300018C22Rik, RIalpha, Tse-1, Tse1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004981 19085 Prkar1b http://www.ncbi.nlm.nih.gov/gene/?term=19085 "AI385716, RIbeta " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004982 19090 Prkdc http://www.ncbi.nlm.nih.gov/gene/?term=19090 "AI326420, AU019811, DNA-PKcs, DNAPDcs, DNAPK, DNPK1, DOXNPH, HYRC1, XRCC7, dxnph, p460, scid, slip " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004983 19091 Prkg1 http://www.ncbi.nlm.nih.gov/gene/?term=19091 "AW125416, CGKI, Gm19690b, Prkgr1b, Prkg1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004984 19094 Mapk11 http://www.ncbi.nlm.nih.gov/gene/?term=19094 "P38b, Prkm11, Sapk2, Sapk2b, p38-2, p38beta, p38beta2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004985 19099 Mapk8ip1 http://www.ncbi.nlm.nih.gov/gene/?term=19099 "IB1, JIP-1, Jip1, Prkm8ip, Skip, mjip-2a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004986 19106 Eif2ak2 http://www.ncbi.nlm.nih.gov/gene/?term=19106 "2310047A08Rik, 4732414G15Rik, AI467567, AI747578, Pkr, Prkr, Tik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00004987 1910 EDNRB http://www.ncbi.nlm.nih.gov/gene/?term=1910 "ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004988 19110 Prl4a1 http://www.ncbi.nlm.nih.gov/gene/?term=19110 "AA409771, Ghd23, PLP-A, Prlpa " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004989 19118 Prm1 http://www.ncbi.nlm.nih.gov/gene/?term=19118 Prm-1 mRNA Mus musculus 26071953 Nucleus Sperm RT-PCR "Within this set of RNAs, the Prm1 transcript, as well as Erich2 and Fam71e2 (formerly 4933404M02Rik and 4930401F20Rik, respectively), were previously identified within the mouse sperm nucleus by RT-PCR though their preferential localization within the gamete could not be inferred from that study (15). " RLID00004990 1911 PHC1 http://www.ncbi.nlm.nih.gov/gene/?term=1911 "EDR1, HPH1, MCPH11, RAE28 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004991 1912 PHC2 http://www.ncbi.nlm.nih.gov/gene/?term=1912 "EDR2, HPH2, PH2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00004992 1912 PHC2 http://www.ncbi.nlm.nih.gov/gene/?term=1912 "EDR2, HPH2, PH2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00004993 19134 Prpf4b http://www.ncbi.nlm.nih.gov/gene/?term=19134 "2610037H07, Prp4, Prp4k, Prpk, cbp143 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004994 19139 Prps1 http://www.ncbi.nlm.nih.gov/gene/?term=19139 "2310010D17Rik, C76571, C76678, PRS-I, Prps-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004995 19143 St14 http://www.ncbi.nlm.nih.gov/gene/?term=19143 "Epithin, MT-SP1, Prss14, Tmprss14, mCAP3, matriptase " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004996 19155 Npepps http://www.ncbi.nlm.nih.gov/gene/?term=19155 "AAP-S, MP100, Psa, R74825, goku " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004997 191578 Helq http://www.ncbi.nlm.nih.gov/gene/?term=191578 "AU021725, D430018E21Rik, Hel308 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00004998 191585 PLAC4 http://www.ncbi.nlm.nih.gov/gene/?term=191585 "C21orf115, PRED78 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00004999 191585 PLAC4 http://www.ncbi.nlm.nih.gov/gene/?term=191585 "C21orf115, PRED78 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005000 1915 EEF1A1 http://www.ncbi.nlm.nih.gov/gene/?term=1915 "CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005001 1915 EEF1A1 http://www.ncbi.nlm.nih.gov/gene/?term=1915 "CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005002 1915 EEF1A1 http://www.ncbi.nlm.nih.gov/gene/?term=1915 "CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005003 1915 EEF1A1 http://www.ncbi.nlm.nih.gov/gene/?term=1915 "CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005004 1915 EEF1A1 http://www.ncbi.nlm.nih.gov/gene/?term=1915 "CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005005 19164 Psen1 http://www.ncbi.nlm.nih.gov/gene/?term=19164 "Ad3h, PS-1, PS1, S182 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005006 19167 Psma3 http://www.ncbi.nlm.nih.gov/gene/?term=19167 Lmpc8 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005007 19167 Psma3 http://www.ncbi.nlm.nih.gov/gene/?term=19167 Lmpc8 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005008 19171 Psmb10 http://www.ncbi.nlm.nih.gov/gene/?term=19171 "Mecl-1, Mecl1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005009 191 AHCY http://www.ncbi.nlm.nih.gov/gene/?term=191 "SAHH, adoHcyase " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005010 191 AHCY http://www.ncbi.nlm.nih.gov/gene/?term=191 "SAHH, adoHcyase " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005011 191 AHCY http://www.ncbi.nlm.nih.gov/gene/?term=191 "SAHH, adoHcyase " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005012 19204 Ptafr http://www.ncbi.nlm.nih.gov/gene/?term=19204 PAFR mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005013 19210 Ptdss1 http://www.ncbi.nlm.nih.gov/gene/?term=19210 "AU044268, AW539008, PSS-1, mKIAA0024 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005014 192111 PGAM5 http://www.ncbi.nlm.nih.gov/gene/?term=192111 BXLBV68 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005015 192111 PGAM5 http://www.ncbi.nlm.nih.gov/gene/?term=192111 BXLBV68 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005016 192119 Dicer1 http://www.ncbi.nlm.nih.gov/gene/?term=192119 "1110006F08Rik, D12Ertd7e, mKIAA0928 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005017 19211 Pten http://www.ncbi.nlm.nih.gov/gene/?term=19211 "2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, MMAC1, TEP1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005018 192156 Mvd http://www.ncbi.nlm.nih.gov/gene/?term=192156 "C78718, Mpd " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005019 192161 Pcdha9 http://www.ncbi.nlm.nih.gov/gene/?term=192161 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005020 192166 Sardh http://www.ncbi.nlm.nih.gov/gene/?term=192166 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005021 192169 Ufsp2 http://www.ncbi.nlm.nih.gov/gene/?term=192169 1810047C23Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005022 192173 Fam195b http://www.ncbi.nlm.nih.gov/gene/?term=192173 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005023 192174 Rwdd4a http://www.ncbi.nlm.nih.gov/gene/?term=192174 "BC016198, Gm1942, Rwdd4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005024 192187 Stab1 http://www.ncbi.nlm.nih.gov/gene/?term=192187 "FEEL-1, FELE-1, MFEEL-1, MS-1, STAB-1, mKIAA0246 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005025 192191 Med9 http://www.ncbi.nlm.nih.gov/gene/?term=192191 "BC019367, Med25 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005026 192192 Shkbp1 http://www.ncbi.nlm.nih.gov/gene/?term=192192 "B930062H15Rik, Sb1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005027 192193 Edem1 http://www.ncbi.nlm.nih.gov/gene/?term=192193 "A130059K23Rik, EDEM, mKIAA0212 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005028 192195 Ash1l http://www.ncbi.nlm.nih.gov/gene/?term=192195 "8030453L17Rik, Ash1, E430018P19Rik, Kmt2h " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005029 192197 Bcas3 http://www.ncbi.nlm.nih.gov/gene/?term=192197 "1500019F07Rik, 2610028P08Rik, AU021018, BC028339, K20D4, rudhira " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005030 19219 Ptger4 http://www.ncbi.nlm.nih.gov/gene/?term=19219 "EP4, Ptgerep4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005031 19221 Ptgfrn http://www.ncbi.nlm.nih.gov/gene/?term=19221 "4833445A08Rik, AU042434, CD9P-1, FPRP, Trim45 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005032 19222 Ptgir http://www.ncbi.nlm.nih.gov/gene/?term=19222 "IP, PGI2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005033 19223 Ptgis http://www.ncbi.nlm.nih.gov/gene/?term=19223 "Cyp8, Cyp8a1, Pgis " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005034 19224 Ptgs1 http://www.ncbi.nlm.nih.gov/gene/?term=19224 "COX1, Cox-1, Cox-3, PGHS-1, PHS 1, Pghs1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005035 192285 Phf21a http://www.ncbi.nlm.nih.gov/gene/?term=192285 "80kDa, Bhc, Bhc80, D030065N23Rik, PFTF1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005036 192286 HIGD2A http://www.ncbi.nlm.nih.gov/gene/?term=192286 RCF1b mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005037 192286 HIGD2A http://www.ncbi.nlm.nih.gov/gene/?term=192286 RCF1b mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005038 19230 Twf1 http://www.ncbi.nlm.nih.gov/gene/?term=19230 "A6, Ptk9, twinfilin " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005039 19231 Ptma http://www.ncbi.nlm.nih.gov/gene/?term=19231 Thym mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005040 19231 Ptma http://www.ncbi.nlm.nih.gov/gene/?term=19231 Thym mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005041 19240 Tmsb10 http://www.ncbi.nlm.nih.gov/gene/?term=19240 "Ptmb10, Tb10 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005042 19240 Tmsb10 http://www.ncbi.nlm.nih.gov/gene/?term=19240 "Ptmb10, Tb10 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005043 19242 Ptn http://www.ncbi.nlm.nih.gov/gene/?term=19242 "HARP, HB-GAM, HBBN, HBGF-8, HBNF, OSF, Osf-1, Osf1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005044 19243 Ptp4a1 http://www.ncbi.nlm.nih.gov/gene/?term=19243 "AA415290, AU019864, C130021B01, Prl-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005045 19244 Ptp4a2 http://www.ncbi.nlm.nih.gov/gene/?term=19244 Prl-2 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005046 19245 Ptp4a3 http://www.ncbi.nlm.nih.gov/gene/?term=19245 "AV088979, Prl-3, pPtp4a3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005047 19246 Ptpn1 http://www.ncbi.nlm.nih.gov/gene/?term=19246 "PTP-1B, PTP-HA2, PTP1B " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005048 19248 Ptpn12 http://www.ncbi.nlm.nih.gov/gene/?term=19248 "P19-PTP, PTP-P19, PTP-PEST, PTPG1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005049 19255 Ptpn2 http://www.ncbi.nlm.nih.gov/gene/?term=19255 "AI325124, Ptpt, TC-PTP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005050 19261 Sirpa http://www.ncbi.nlm.nih.gov/gene/?term=19261 "AI835480, Bit, CD172a, P84, Ptpns1, SHP-1, SHPS-1, SIRP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005051 19262 Ptpra http://www.ncbi.nlm.nih.gov/gene/?term=19262 "Ptpa, Ptpalpha, Rptpalpha, Rptra, Rptralpha " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005052 192662 Arhgdia http://www.ncbi.nlm.nih.gov/gene/?term=192662 "5330430M07Rik, Gdi-1, Rho-GDI, RhoDGI, RhoGDI-1 " mRNA Mus musculus 25301173 Dendrite Hippocampus In situ hybridization "Figure 2: In situ hybridization reveals species-specific patterns of localization in neuronal dendrites. Fluorescent Microscopy evaluation of biotin-conjugated oligoprobes on paraformaldehyde fixed 14-day cultured rat and mouse cortical neurons hybridized with nine biotin-conjugated oligoprobes detected with streptadivin-Alexa Fluor 568 (Invitrogen). For each probe images set, the small bottom left corner panels represent MAP2 immuno-staining. Scale bar = 20um. (A), Probes against SFRS16, ARHGDIA and HNRPK transcripts show higher dendritic localization in mouse neurons than in rat neurons (Red box). (B), Probes against ZFP410, COMMD3 and RSP6 transcripts show higher dendritic localization in rat neurons than in mouse neurons (Blue box). (C), Probes against UBA52, OLFM1 and H2AFZ transcripts show high dendritic localization in both rat and mouse neurons (Black box). Data are collected from Figure 2. " RLID00005053 192669 AGO3 http://www.ncbi.nlm.nih.gov/gene/?term=192669 EIF2C3 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005054 19267 Ptpre http://www.ncbi.nlm.nih.gov/gene/?term=19267 "PTPe, PTPepsilon, RPTPepsilon " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005055 19268 Ptprf http://www.ncbi.nlm.nih.gov/gene/?term=19268 "AA591035, LAR, LARS, RPTP-LAR " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005056 19272 Ptprk http://www.ncbi.nlm.nih.gov/gene/?term=19272 "AI853699, PTPk, RPTPkappa " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005057 19275 Ptprn http://www.ncbi.nlm.nih.gov/gene/?term=19275 "IA-2, mIA-A, mKIAA4064 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005058 192786 Rapgef6 http://www.ncbi.nlm.nih.gov/gene/?term=192786 "A530068K01, AI844632, BB085664, C030018K18Rik, PDZ-GEF2, Pdzgef2, RA-GEF-2, Ragef2, mKIAA4052 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005059 19288 Ptx3 http://www.ncbi.nlm.nih.gov/gene/?term=19288 "AI607804, TSG-14 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005060 19291 Purb http://www.ncbi.nlm.nih.gov/gene/?term=19291 "2310015K15Rik, AA114818, Cager-2, D11Bwg0414e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005061 19296 Pvt1 http://www.ncbi.nlm.nih.gov/gene/?term=19296 "Ayu21-84Imeg, Gt(pU21)84Imeg, Mis-1, Mlvi-1, Pvt-1 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005062 192976 Lrrc75a http://www.ncbi.nlm.nih.gov/gene/?term=192976 Fam211a mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005063 19298 Pex19 http://www.ncbi.nlm.nih.gov/gene/?term=19298 Pxf mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005064 19299 Abcd3 http://www.ncbi.nlm.nih.gov/gene/?term=19299 "AI313901, AU018866, AW146054, PMP68, PMP70, Pxmp1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005065 19300 Abcd4 http://www.ncbi.nlm.nih.gov/gene/?term=19300 "P69r, P70R, Pxmp1l " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005066 193116 Slu7 http://www.ncbi.nlm.nih.gov/gene/?term=193116 "AU018913, D11Ertd730e, D3Bwg0878e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005067 19317 Qk http://www.ncbi.nlm.nih.gov/gene/?term=19317 "1110003F05Rik, 1500005P18I, l(17)-1Wis, l17Wis1, Qk " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005068 19317 Qk http://www.ncbi.nlm.nih.gov/gene/?term=19317 "1110003F05Rik, 1500005P18I, l(17)-1Wis, l17Wis1, Qk " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005069 19325 Rab10 http://www.ncbi.nlm.nih.gov/gene/?term=19325 AW107754 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005070 19330 Rab18 http://www.ncbi.nlm.nih.gov/gene/?term=19330 AA959686 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005071 19334 Rab22a http://www.ncbi.nlm.nih.gov/gene/?term=19334 "3732413A17Rik, AI662177, AW319644, AW550514, E130120E14Rik, Rab22 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005072 19339 Rab3a http://www.ncbi.nlm.nih.gov/gene/?term=19339 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005073 19341 Rab4a http://www.ncbi.nlm.nih.gov/gene/?term=19341 "AI848268, Rab4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005074 19342 Rab4b http://www.ncbi.nlm.nih.gov/gene/?term=19342 1500031G17Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005075 19352 Rabggtb http://www.ncbi.nlm.nih.gov/gene/?term=19352 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005076 19357 Rad21 http://www.ncbi.nlm.nih.gov/gene/?term=19357 "SCC1, mKIAA0078 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005077 19360 Rad50 http://www.ncbi.nlm.nih.gov/gene/?term=19360 "Mrelll, Rad50 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005078 19364 Rad51d http://www.ncbi.nlm.nih.gov/gene/?term=19364 "R51H3, Rad51l3, TRAD, Trad-d5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005079 19364 Rad51d http://www.ncbi.nlm.nih.gov/gene/?term=19364 "R51H3, Rad51l3, TRAD, Trad-d5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005080 19366 Rad54l http://www.ncbi.nlm.nih.gov/gene/?term=19366 RAD54 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005081 1936 EEF1D http://www.ncbi.nlm.nih.gov/gene/?term=1936 "EF-1D, EF1D, FP1047 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005082 1936 EEF1D http://www.ncbi.nlm.nih.gov/gene/?term=1936 "EF-1D, EF1D, FP1047 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005083 1936 EEF1D http://www.ncbi.nlm.nih.gov/gene/?term=1936 "EF-1D, EF1D, FP1047 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005084 1936 EEF1D http://www.ncbi.nlm.nih.gov/gene/?term=1936 "EF-1D, EF1D, FP1047 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005085 193740 Hspa1a http://www.ncbi.nlm.nih.gov/gene/?term=193740 "Hsp70-3, Hsp70.3, Hsp72, hsp68, hsp70A1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005086 193742 Abhd16a http://www.ncbi.nlm.nih.gov/gene/?term=193742 "AI326074, Bat-5, Bat5, D17H6S82E, NG26 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005087 19374 Rag2 http://www.ncbi.nlm.nih.gov/gene/?term=19374 Rag-2 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005088 19377 Rai1 http://www.ncbi.nlm.nih.gov/gene/?term=19377 Gt1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005089 1937 EEF1G http://www.ncbi.nlm.nih.gov/gene/?term=1937 "EF1G, GIG35 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005090 1937 EEF1G http://www.ncbi.nlm.nih.gov/gene/?term=1937 "EF1G, GIG35 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005091 1937 EEF1G http://www.ncbi.nlm.nih.gov/gene/?term=1937 "EF1G, GIG35 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005092 193813 Mcfd2 http://www.ncbi.nlm.nih.gov/gene/?term=193813 "1810021C21Rik, F5f8d, Lman1ip, Sdnsf " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005093 19384 Ran http://www.ncbi.nlm.nih.gov/gene/?term=19384 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005094 19386 Ranbp2 http://www.ncbi.nlm.nih.gov/gene/?term=19386 "A430087B05Rik, AI256741, NUP358 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005095 1938 EEF2 http://www.ncbi.nlm.nih.gov/gene/?term=1938 "EEF-2, EF-2, EF2, SCA26 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005096 1938 EEF2 http://www.ncbi.nlm.nih.gov/gene/?term=1938 "EEF-2, EF-2, EF2, SCA26 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005097 1938 EEF2 http://www.ncbi.nlm.nih.gov/gene/?term=1938 "EEF-2, EF-2, EF2, SCA26 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005098 19400 Rapsn http://www.ncbi.nlm.nih.gov/gene/?term=19400 "43kDa, Nraps, Raps, rapsyn " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005099 19411 Rarg http://www.ncbi.nlm.nih.gov/gene/?term=19411 "Nr1b3, RAR-gamma, RARD, RARgamma2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005100 19416 Rasd1 http://www.ncbi.nlm.nih.gov/gene/?term=19416 Dexras1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005101 1942 EFNA1 http://www.ncbi.nlm.nih.gov/gene/?term=1942 "B61, ECKLG, EFL1, EPLG1, LERK-1, LERK1, TNFAIP4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005102 194433 Olfr707 http://www.ncbi.nlm.nih.gov/gene/?term=194433 MOR260-8P mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005103 1945 EFNA4 http://www.ncbi.nlm.nih.gov/gene/?term=1945 "EFL4, EPLG4, LERK4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005104 194738 Rhox11 http://www.ncbi.nlm.nih.gov/gene/?term=194738 "BC049711, Gm39 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005105 1947 EFNB1 http://www.ncbi.nlm.nih.gov/gene/?term=1947 "CFND, CFNS, EFB1, EFL3, EPLG2, Elk-L, LERK2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005106 1947 EFNB1 http://www.ncbi.nlm.nih.gov/gene/?term=1947 "CFND, CFNS, EFB1, EFL3, EPLG2, Elk-L, LERK2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005107 1948 EFNB2 http://www.ncbi.nlm.nih.gov/gene/?term=1948 "EPLG5, HTKL, Htk-L, LERK5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005108 1948 EFNB2 http://www.ncbi.nlm.nih.gov/gene/?term=1948 "EPLG5, HTKL, Htk-L, LERK5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005109 1948 EFNB2 http://www.ncbi.nlm.nih.gov/gene/?term=1948 "EPLG5, HTKL, Htk-L, LERK5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005110 195018 Zzef1 http://www.ncbi.nlm.nih.gov/gene/?term=195018 "8430405D05Rik, BC051585, C130099L13Rik, C85424, NSPA, mKIAA0399 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005111 195018 Zzef1 http://www.ncbi.nlm.nih.gov/gene/?term=195018 "8430405D05Rik, BC051585, C130099L13Rik, C85424, NSPA, mKIAA0399 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005112 1951 CELSR3 http://www.ncbi.nlm.nih.gov/gene/?term=1951 "ADGRC3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005113 1952 CELSR2 http://www.ncbi.nlm.nih.gov/gene/?term=1952 "ADGRC2, CDHF10, EGFL2, Flamingo1, MEGF3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005114 1953 MEGF6 http://www.ncbi.nlm.nih.gov/gene/?term=1953 EGFL3 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005115 1954 MEGF8 http://www.ncbi.nlm.nih.gov/gene/?term=1954 "C19orf49, CRPT2, EGFL4, SBP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005116 1955 MEGF9 http://www.ncbi.nlm.nih.gov/gene/?term=1955 EGFL5 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005117 1956 EGFR http://www.ncbi.nlm.nih.gov/gene/?term=1956 "ERBB, ERBB1, HER1, NISBD2, PIG61, mENA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005118 1956 EGFR http://www.ncbi.nlm.nih.gov/gene/?term=1956 "ERBB, ERBB1, HER1, NISBD2, PIG61, mENA " mRNA Homo sapiens 1983869 Cytoplasm Breast cell cancer In situ hybridization "EGF-R mRNA was observed principally at the cytoplasmic level, on organelles involved in the protein synthesis process. Labeling was also located on the microvilli which extend into the intercellular space, suggesting that some mRNA would be located in sites where EGF-R is utilized. Some mRNA was observed in the nucleus. " RLID00005119 1956 EGFR http://www.ncbi.nlm.nih.gov/gene/?term=1956 "ERBB, ERBB1, HER1, NISBD2, PIG61, mENA " mRNA Homo sapiens 20453113 Endoplasmic reticulum NCI/ADR-RES cell qRT-PCR "The relative partitioning of both cytosolic (ACTB, H3.3) and ER-bound (MDR1, CANX) transcripts between both fractions was marked, despite the small carryover of cytosol in the ER fraction (Fig. 2B). Polysome profile analyses from the isolated fractions indicated that these transcripts migrated in polyribosome-containing fractions (Fig. 2C). Notably, the distribution of ER-bound transcripts between the ER and cytosol did not change on arsenite treatment of NCI/ADR-RES cells (Fig. 2D). Data are collected from Figure 2. " RLID00005120 1956 EGFR http://www.ncbi.nlm.nih.gov/gene/?term=1956 "ERBB, ERBB1, HER1, NISBD2, PIG61, mENA " mRNA Homo sapiens 1983869 Nucleus Breast cell cancer In situ hybridization "EGF-R mRNA was observed principally at the cytoplasmic level, on organelles involved in the protein synthesis process. Labeling was also located on the microvilli which extend into the intercellular space, suggesting that some mRNA would be located in sites where EGF-R is utilized. Some mRNA was observed in the nucleus. " RLID00005121 195827 AAED1 http://www.ncbi.nlm.nih.gov/gene/?term=195827 C9orf21 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005122 195828 ZNF367 http://www.ncbi.nlm.nih.gov/gene/?term=195828 "AFF29, CDC14B, ZFF29 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005123 195828 ZNF367 http://www.ncbi.nlm.nih.gov/gene/?term=195828 "AFF29, CDC14B, ZFF29 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005124 1958 EGR1 http://www.ncbi.nlm.nih.gov/gene/?term=1958 "AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005125 1958 EGR1 http://www.ncbi.nlm.nih.gov/gene/?term=1958 "AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005126 1958 EGR1 http://www.ncbi.nlm.nih.gov/gene/?term=1958 "AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005127 196047 EMX2OS http://www.ncbi.nlm.nih.gov/gene/?term=196047 "EMX2-AS1, NCRNA00045 " lncRNA Homo sapiens 21128942 Nucleus Brain tissue qRT-PCR|Microarray Table 2: Long noncoding RNAs represented on Affymetrix U133 arrays that were reliably detected in human nucleus accumbens. An lncRNA was considered reliably detected in human NAcc if at least one probe corresponding to the transcript gave a specific signal in all control subjects. No transcripts undetected in the controls were consistently detected in drug abusers. Data are collected from Talbe 2. RLID00005128 196051 PLPP4 http://www.ncbi.nlm.nih.gov/gene/?term=196051 "DPPL2, PPAPDC1, PPAPDC1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005129 1960 EGR3 http://www.ncbi.nlm.nih.gov/gene/?term=1960 "EGR-3, PILOT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005130 1961 EGR4 http://www.ncbi.nlm.nih.gov/gene/?term=1961 "NGFI-C, NGFIC, PAT133 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005131 196264 MPZL3 http://www.ncbi.nlm.nih.gov/gene/?term=196264 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005132 196383 RILPL2 http://www.ncbi.nlm.nih.gov/gene/?term=196383 RLP2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005133 196383 RILPL2 http://www.ncbi.nlm.nih.gov/gene/?term=196383 RLP2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005134 196383 RILPL2 http://www.ncbi.nlm.nih.gov/gene/?term=196383 RLP2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005135 196410 METTL7B http://www.ncbi.nlm.nih.gov/gene/?term=196410 ALDI mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005136 196441 ZFC3H1 http://www.ncbi.nlm.nih.gov/gene/?term=196441 "CCDC131, PSRC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005137 196441 ZFC3H1 http://www.ncbi.nlm.nih.gov/gene/?term=196441 "CCDC131, CSRC2, PSRC2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005138 196441 ZFC3H1 http://www.ncbi.nlm.nih.gov/gene/?term=196441 "CCDC131, CSRC2, PSRC2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005139 19646 Rbbp4 http://www.ncbi.nlm.nih.gov/gene/?term=19646 "RBAP48, mRbAp48 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005140 196475 RMST http://www.ncbi.nlm.nih.gov/gene/?term=196475 "LINC00054, NCRMS, NCRNA00054 " lncRNA Homo sapiens 22193719 Nucleus Embryonic stem cell qRT-PCR|Microarray "Figure 7: Neuronal lncRNAs act via diverse mechanisms. (A) Quantification of relative expression of lncRNAs in nuclear and cytoplasmic cell fractions. (B) Quantification of changes in hosted miRNAs in response to lncRNA_N2 knockdown. MiRNAs were quantified using Taqman miRNA qPCR. (C-E) RIP of lncRNAs with SUZ12 and REST antibodies. The interaction of HOTAIR with SUZ12 is a known interaction that serves as a positive control (Gupta et al, 2010). * and ** indicate P-values of <0.05 and <0.01, respectively. Data are collected from Figure 7. " RLID00005141 196483 EEF2KMT http://www.ncbi.nlm.nih.gov/gene/?term=196483 "FAM86A, SB153, eEF2-KMT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005142 1964 EIF1AX http://www.ncbi.nlm.nih.gov/gene/?term=1964 "EIF1A, EIF1AP1, EIF4C, eIF-1A, eIF-4C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005143 1964 EIF1AX http://www.ncbi.nlm.nih.gov/gene/?term=1964 "EIF1A, EIF1AP1, EIF4C, eIF-1A, eIF-4C " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005144 1964 EIF1AX http://www.ncbi.nlm.nih.gov/gene/?term=1964 "EIF1A, EIF1AP1, EIF4C, eIF-1A, eIF-4C " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005145 19650 Rbl1 http://www.ncbi.nlm.nih.gov/gene/?term=19650 "AW547426, PRB1, p107 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005146 196513 DCP1B http://www.ncbi.nlm.nih.gov/gene/?term=196513 DCP1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005147 196513 DCP1B http://www.ncbi.nlm.nih.gov/gene/?term=196513 DCP1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005148 19651 Rbl2 http://www.ncbi.nlm.nih.gov/gene/?term=19651 "PRB2, RBR-2, Rb2, p130 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005149 196527 ANO6 http://www.ncbi.nlm.nih.gov/gene/?term=196527 "BDPLT7, SCTS, TMEM16F " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005150 196528 ARID2 http://www.ncbi.nlm.nih.gov/gene/?term=196528 "BAF200, p200 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005151 19652 Rbm3 http://www.ncbi.nlm.nih.gov/gene/?term=19652 2600016C11Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005152 19653 Rbm4 http://www.ncbi.nlm.nih.gov/gene/?term=19653 "4921506I22Rik, Lark1, Mlarka, lark, Rbm4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005153 19656 Rbmxl1 http://www.ncbi.nlm.nih.gov/gene/?term=19656 "Hnrpg, Rbmx, Rbmxrt " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005154 1965 EIF2S1 http://www.ncbi.nlm.nih.gov/gene/?term=1965 "EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005155 1965 EIF2S1 http://www.ncbi.nlm.nih.gov/gene/?term=1965 "EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005156 1965 EIF2S1 http://www.ncbi.nlm.nih.gov/gene/?term=1965 "EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005157 19663 Rbpms http://www.ncbi.nlm.nih.gov/gene/?term=19663 "2010300K22Rik, 2700019M19Rik, AU017537, RBP-MS, hermes " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005158 19663 Rbpms http://www.ncbi.nlm.nih.gov/gene/?term=19663 "2010300K22Rik, 2700019M19Rik, AU017537, RBP-MS, hermes " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005159 19664 Rbpj http://www.ncbi.nlm.nih.gov/gene/?term=19664 "AI843960, CBF1, Igkjrb, Igkrsbp, RBP-J, RBP-J kappa, RBP-Jkappa, RBPjk, Rbpsuh " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005160 196740 VSTM4 http://www.ncbi.nlm.nih.gov/gene/?term=196740 C10orf72 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005161 196740 VSTM4 http://www.ncbi.nlm.nih.gov/gene/?term=196740 C10orf72 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005162 1967 EIF2B1 http://www.ncbi.nlm.nih.gov/gene/?term=1967 "EIF2B, EIF2BA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005163 1967 EIF2B1 http://www.ncbi.nlm.nih.gov/gene/?term=1967 "EIF2B, EIF2BA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005164 1967 EIF2B1 http://www.ncbi.nlm.nih.gov/gene/?term=1967 "EIF2B, EIF2BA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005165 19684 Rdx http://www.ncbi.nlm.nih.gov/gene/?term=19684 AA516625 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005166 1968 EIF2S3 http://www.ncbi.nlm.nih.gov/gene/?term=1968 "EIF2, EIF2G, EIF2gamma, eIF-2gA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005167 1968 EIF2S3 http://www.ncbi.nlm.nih.gov/gene/?term=1968 "EIF2, EIF2G, EIF2gamma, eIF-2gA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005168 1968 EIF2S3 http://www.ncbi.nlm.nih.gov/gene/?term=1968 "EIF2, EIF2G, EIF2gamma, eIF-2gA " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005169 19691 Recql http://www.ncbi.nlm.nih.gov/gene/?term=19691 RecQ1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005170 19691 Recql http://www.ncbi.nlm.nih.gov/gene/?term=19691 RecQ1 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005171 19698 Relb http://www.ncbi.nlm.nih.gov/gene/?term=19698 shep mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005172 196 AHR http://www.ncbi.nlm.nih.gov/gene/?term=196 bHLHe76 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005173 196 AHR http://www.ncbi.nlm.nih.gov/gene/?term=196 bHLHe76 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005174 196 AHR http://www.ncbi.nlm.nih.gov/gene/?term=196 bHLHe76 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005175 196 AHR http://www.ncbi.nlm.nih.gov/gene/?term=196 bHLHe76 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005176 196 AHR http://www.ncbi.nlm.nih.gov/gene/?term=196 bHLHe76 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005177 19712 Rest http://www.ncbi.nlm.nih.gov/gene/?term=19712 "2610008J04Rik, AA407358, NRSF, REST4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005178 197131 UBR1 http://www.ncbi.nlm.nih.gov/gene/?term=197131 JBS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005179 197131 UBR1 http://www.ncbi.nlm.nih.gov/gene/?term=197131 JBS mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005180 19713 Ret http://www.ncbi.nlm.nih.gov/gene/?term=19713 "PTC, RET51, RET9, c-Ret " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005181 19714 Rev3l http://www.ncbi.nlm.nih.gov/gene/?term=19714 "Rev, Rev3, Sez4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005182 19726 Rfx3 http://www.ncbi.nlm.nih.gov/gene/?term=19726 "C230093O12Rik, MRFX3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005183 197335 WDR90 http://www.ncbi.nlm.nih.gov/gene/?term=197335 "C16orf15, C16orf16, C16orf17, C16orf18, C16orf19 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005184 197335 WDR90 http://www.ncbi.nlm.nih.gov/gene/?term=197335 "C16orf15, C16orf16, C16orf17, C16orf18, C16orf19 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005185 19734 Rgs16 http://www.ncbi.nlm.nih.gov/gene/?term=19734 "Rgs14, Rgsr " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005186 197358 NLRC3 http://www.ncbi.nlm.nih.gov/gene/?term=197358 "CLR16.2, NOD3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005187 197358 NLRC3 http://www.ncbi.nlm.nih.gov/gene/?term=197358 "CLR16.2, NOD3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005188 19735 Rgs2 http://www.ncbi.nlm.nih.gov/gene/?term=19735 GOS8 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005189 197370 NSMCE1 http://www.ncbi.nlm.nih.gov/gene/?term=197370 NSE1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005190 197370 NSMCE1 http://www.ncbi.nlm.nih.gov/gene/?term=197370 NSE1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005191 197370 NSMCE1 http://www.ncbi.nlm.nih.gov/gene/?term=197370 NSE1 mRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00005192 1973 EIF4A1 http://www.ncbi.nlm.nih.gov/gene/?term=1973 "DDX2A, EIF-4A, EIF4A, eIF-4A-I, eIF4A-I " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005193 197407 ZNF48 http://www.ncbi.nlm.nih.gov/gene/?term=197407 ZNF553 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005194 1974 EIF4A2 http://www.ncbi.nlm.nih.gov/gene/?term=1974 "BM-010, DDX2B, EIF4A, EIF4F, eIF-4A-II, eIF4A-II " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005195 1975 EIF4B http://www.ncbi.nlm.nih.gov/gene/?term=1975 "EIF-4B, PRO1843 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005196 19775 Xpr1 http://www.ncbi.nlm.nih.gov/gene/?term=19775 "Rmc-1, Rmc1, Sxv, Syg1, XR " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005197 1977 EIF4E http://www.ncbi.nlm.nih.gov/gene/?term=1977 "AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F, eIF-4E " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005198 1977 EIF4E http://www.ncbi.nlm.nih.gov/gene/?term=1977 "AUTS19, CBP1, EIF4EL1, EIF4F, eIF-4E, EIF4E " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005199 1977 EIF4E http://www.ncbi.nlm.nih.gov/gene/?term=1977 "AUTS19, CBP1, EIF4EL1, EIF4F, eIF-4E, EIF4E " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005200 1977 EIF4E http://www.ncbi.nlm.nih.gov/gene/?term=1977 "AUTS19, CBP1, EIF4EL1, EIF4F, eIF-4E, EIF4E " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005201 1977 EIF4E http://www.ncbi.nlm.nih.gov/gene/?term=1977 "AUTS19, CBP1, EIF4EL1, EIF4F, eIF-4E, EIF4E " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005202 1978 EIF4EBP1 http://www.ncbi.nlm.nih.gov/gene/?term=1978 "4E-BP1, 4EBP1, BP-1, PHAS-I " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005203 19791 Rn18s http://www.ncbi.nlm.nih.gov/gene/?term=19791 rRNA Mus musculus 26178919 Nucleolus Embryo In situ hybridization "Furthermore, at the morula stage, whereas 18S rRNA and ribosomal protein S6 (rpS7), which are components of the ribosome, were distributed to the cytoplasm in WT embryos, they were mainly localized in the nucleoli in Nepro KO embryos. At the 4-cell stage, the expression of 18S rRNA and rpS6 were detected in the nucleolus and cytoplasm at low level in both Nepro +/ and Nepro -/- (Fig. 4A). The majority of 18S rRNA and rpS6 was detected in nucleoli but not the cytoplasm in Nepro embryos at the morula stage. " RLID00005204 19791 Rn18s http://www.ncbi.nlm.nih.gov/gene/?term=19791 rRNA Mus musculus 26178919 Cytoplasm Embryo In situ hybridization "Furthermore, at the morula stage, whereas 18S rRNA and ribosomal protein S6 (rpS6), which are components of the ribosome, were distributed to the cytoplasm in WT embryos, they were mainly localized in the nucleoli in Nepro KO embryos. At the morula stage, whereas 18S rRNA and rpS6 were distributed in the cytoplasm in Nepro +/ embryos, they were mainly restricted in nucleoli in Nepro -/- embryos (Fig. 4B). " RLID00005205 19791 Rn18s http://www.ncbi.nlm.nih.gov/gene/?term=19791 rRNA Mus musculus 26464439 Cytoplasm Motoneuron In situ hybridization|qRT-PCR "18S rRNA, a component of ribosomes, was similarly present in the cytoplasm and in motor axons. " RLID00005206 19791 Rn18s http://www.ncbi.nlm.nih.gov/gene/?term=19791 rRNA Mus musculus 26464439 Axon Motoneuron In situ hybridization|qRT-PCR "18S rRNA, a component of ribosomes, was similarly present in the cytoplasm and in motor axons. " RLID00005207 19791 Rn18s http://www.ncbi.nlm.nih.gov/gene/?term=19791 rRNA Mus musculus 18410515 Synapse ForeBrain qRT-PCR "We noted that levels of all RNAs measured, including ribosomal 18S RNA, U6, CAMK2a and BC1, as well as mature microRNAs and their precursors, were lower in synaptosomes relative to that observed in synaptoneurosomes. " RLID00005208 1979 EIF4EBP2 http://www.ncbi.nlm.nih.gov/gene/?term=1979 "4EBP2, PHASII " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005209 1979 EIF4EBP2 http://www.ncbi.nlm.nih.gov/gene/?term=1979 "4EBP2, PHASII " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005210 1979 EIF4EBP2 http://www.ncbi.nlm.nih.gov/gene/?term=1979 "4EBP2, PHASII " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005211 1979 EIF4EBP2 http://www.ncbi.nlm.nih.gov/gene/?term=1979 "4EBP2, PHASII " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005212 197 AHSG http://www.ncbi.nlm.nih.gov/gene/?term=197 "A2HS, AHS, FETUA, HSGA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005213 19817 Rn7sk http://www.ncbi.nlm.nih.gov/gene/?term=19817 snRNA Mus musculus 26179904 Nucleus Macrophage qRT-PCR "As expected, the mature IL-1a and Gapdh transcripts were localized to the cytosol, whereas 7SK RNA was confined to the nucleus. " RLID00005214 19817 Rn7sk http://www.ncbi.nlm.nih.gov/gene/?term=19817 snRNA Mus musculus 26464439 Somatodendritic compartment Motoneuron In situ hybridization|qRT-PCR "The somatodendritic compartment was enriched for transcripts with post-synaptic functions as well as for certain nuclear non-coding RNAs such as 7SK. We found 7SK relatively more abundant in the somatodendritic compartment, but also detectable in motor axons, which we validated by qPCR (see Figure 8A). In our motoneuron dataset we found 7SK more abundant in the somatodendritic compared to the axonal cytoplasm in line with its nuclear function in transcriptional regulation (33). " RLID00005215 19817 Rn7sk http://www.ncbi.nlm.nih.gov/gene/?term=19817 snRNA Mus musculus 26464439 Axon Motoneuron In situ hybridization|qRT-PCR "We found 7SK relatively more abundant in the somatodendritic compartment, but also detectable in motor axons, which we validated by qPCR (see Figure 8A). In our motoneuron dataset we found 7SK more abundant in the somatodendritic compared to the axonal cytoplasm in line with its nuclear function in transcriptional regulation (33). " RLID00005216 1981 EIF4G1 http://www.ncbi.nlm.nih.gov/gene/?term=1981 "EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005217 19821 Rnf2 http://www.ncbi.nlm.nih.gov/gene/?term=19821 "AI326319, AI450156, AU019207, Ring1B, dinG " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005218 19822 Rnf4 http://www.ncbi.nlm.nih.gov/gene/?term=19822 "AU018689, Gtrgeo8, SNURF " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005219 19826 Rnps1 http://www.ncbi.nlm.nih.gov/gene/?term=19826 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005220 1982 EIF4G2 http://www.ncbi.nlm.nih.gov/gene/?term=1982 "AAG1, DAP5, NAT1, P97 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005221 19835230 tRNA:CR45107 http://www.ncbi.nlm.nih.gov/gene/?term=19835230 "Dmel_CR45107, AE002787.trna24-ThrTGT, CR30261, CR30505, CR45107, Dmel\CR45107, chr2R.trna83-ThrTGT, tRNA:CR30505, tRNA:T3:47F, tRNA:T:TGT:AE002787-a, tRNA:thr3:47F, tRNA[Thr][[3]], tRNA[[Thr]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0266574.html RLID00005222 19836221 tRNA:CR45106 http://www.ncbi.nlm.nih.gov/gene/?term=19836221 "Dmel_CR45106, AE002787.trna33-ThrTGT, CR30260, CR45106, Dmel\CR45106, chr2R.trna15-ThrTGT, tRNA:CR30260, tRNA:T3:47F, tRNA:T:TGT:AE002787-d, tRNA:thr3:47F, tRNA[Thr][[3]], tRNA[[Thr]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0266573.html RLID00005223 1983 EIF5 http://www.ncbi.nlm.nih.gov/gene/?term=1983 "EIF-5, EIF-5A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005224 1983 EIF5 http://www.ncbi.nlm.nih.gov/gene/?term=1983 "EIF-5, EIF-5A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005225 1983 EIF5 http://www.ncbi.nlm.nih.gov/gene/?term=1983 "EIF-5, EIF-5A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005226 1984 EIF5A http://www.ncbi.nlm.nih.gov/gene/?term=1984 "EIF-5A1, eIF5AI, EIF5A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005227 19876 Robo1 http://www.ncbi.nlm.nih.gov/gene/?term=19876 "AW494633, AW742721, DUTT1, Gm310 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005228 19877 Rock1 http://www.ncbi.nlm.nih.gov/gene/?term=19877 "1110055K06Rik, Rock-I " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005229 19878 Rock2 http://www.ncbi.nlm.nih.gov/gene/?term=19878 "B230113H15Rik, ROKalpha, Rho-kinase, Rock-IIm, mKIAA0619, Rock2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005230 19883 Rora http://www.ncbi.nlm.nih.gov/gene/?term=19883 "9530021D13Rik, Nr1f1, ROR1, ROR2, ROR3, nmf267, sg, staggerer, tmgc26 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005231 19889 Rp2 http://www.ncbi.nlm.nih.gov/gene/?term=19889 "AI662636h, Rp2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005232 19896 Rpl10a http://www.ncbi.nlm.nih.gov/gene/?term=19896 "CsA-19, Nedd6 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005233 19896 Rpl10a http://www.ncbi.nlm.nih.gov/gene/?term=19896 "CsA-19, Nedd6 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005234 19899 Rpl18 http://www.ncbi.nlm.nih.gov/gene/?term=19899 "L18a, Rpl18 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005235 19921 Rpl19 http://www.ncbi.nlm.nih.gov/gene/?term=19921 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005236 1992 SERPINB1 http://www.ncbi.nlm.nih.gov/gene/?term=1992 "EI, ELANH2, HEL-S-27, HEL57, LEI, M/NEI, MNEI, PI-2, PI2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005237 1992 SERPINB1 http://www.ncbi.nlm.nih.gov/gene/?term=1992 "EI, ELANH2, HEL-S-27, HEL57, LEI, M/NEI, MNEI, PI-2, PI2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005238 1992 SERPINB1 http://www.ncbi.nlm.nih.gov/gene/?term=1992 "EI, ELANH2, HEL-S-27, HEL57, LEI, M/NEI, MNEI, PI-2, PI2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005239 19933 Rpl21 http://www.ncbi.nlm.nih.gov/gene/?term=19933 "8430440E03Rik, L21 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005240 19933 Rpl21 http://www.ncbi.nlm.nih.gov/gene/?term=19933 "8430440E03Rik, L21 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005241 19934 Rpl22 http://www.ncbi.nlm.nih.gov/gene/?term=19934 2700038K18Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005242 19934 Rpl22 http://www.ncbi.nlm.nih.gov/gene/?term=19934 2700038K18Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005243 19941 Rpl26 http://www.ncbi.nlm.nih.gov/gene/?term=19941 SIG-20 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005244 19942 Rpl27 http://www.ncbi.nlm.nih.gov/gene/?term=19942 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005245 19942 Rpl27 http://www.ncbi.nlm.nih.gov/gene/?term=19942 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005246 19943 Rpl28 http://www.ncbi.nlm.nih.gov/gene/?term=19943 D7Wsu21e mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005247 19943 Rpl28 http://www.ncbi.nlm.nih.gov/gene/?term=19943 D7Wsu21e mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005248 19944 Rpl29 http://www.ncbi.nlm.nih.gov/gene/?term=19944 Rpl43 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005249 19946 Rpl30 http://www.ncbi.nlm.nih.gov/gene/?term=19946 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005250 1994 ELAVL1 http://www.ncbi.nlm.nih.gov/gene/?term=1994 "ELAV1, HUR, Hua, MelG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005251 1994 ELAVL1 http://www.ncbi.nlm.nih.gov/gene/?term=1994 "ELAV1, HUR, Hua, MelG " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005252 19951 Rpl32 http://www.ncbi.nlm.nih.gov/gene/?term=19951 "AU020185, rpL32-3A " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005253 199675 MCEMP1 http://www.ncbi.nlm.nih.gov/gene/?term=199675 C19orf59 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005254 199692 ZNF627 http://www.ncbi.nlm.nih.gov/gene/?term=199692 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005255 199699 DAND5 http://www.ncbi.nlm.nih.gov/gene/?term=199699 "CER2, CERL2, CKTSF1B3, COCO, CRL2, DANTE, GREM3, SP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005256 199699 DAND5 http://www.ncbi.nlm.nih.gov/gene/?term=199699 "CER2, CERL2, CKTSF1B3, COCO, CRL2, DANTE, GREM3, SP1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005257 199720 GGN http://www.ncbi.nlm.nih.gov/gene/?term=199720 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005258 199731 CADM4 http://www.ncbi.nlm.nih.gov/gene/?term=199731 "IGSF4C, NECL4, Necl-4, TSLL2, synCAM4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005259 199746 U2AF1L4 http://www.ncbi.nlm.nih.gov/gene/?term=199746 "U2AF1-RS3, U2AF1L3, U2AF1L3V1, U2AF1RS3, U2af26 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005260 1997 ELF1 http://www.ncbi.nlm.nih.gov/gene/?term=1997 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005261 19981 Rpl37a http://www.ncbi.nlm.nih.gov/gene/?term=19981 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005262 19982 Rpl36a http://www.ncbi.nlm.nih.gov/gene/?term=19982 "L44L, Rpl44 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005263 199857 ALG14 http://www.ncbi.nlm.nih.gov/gene/?term=199857 CMS15 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005264 19989 Rpl7 http://www.ncbi.nlm.nih.gov/gene/?term=19989 "Rpl7a, Surf-3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005265 19989 Rpl7 http://www.ncbi.nlm.nih.gov/gene/?term=19989 "Rpl7a, Surf-3 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005266 1998 ELF2 http://www.ncbi.nlm.nih.gov/gene/?term=1998 "EU32, NERF, NERF-1A, NERF-1B, NERF-1a, b, NERF-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005267 1998 ELF2 http://www.ncbi.nlm.nih.gov/gene/?term=1998 "EU32, NERF, NERF-1A, NERF-1B, NERF-1a, b, NERF-2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005268 1998 ELF2 http://www.ncbi.nlm.nih.gov/gene/?term=1998 "EU32, NERF, NERF-1A, NERF-1B, NERF-1a, b, NERF-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005269 199953 TMEM201 http://www.ncbi.nlm.nih.gov/gene/?term=199953 NET5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005270 199964 TMEM61 http://www.ncbi.nlm.nih.gov/gene/?term=199964 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005271 199990 FAAP20 http://www.ncbi.nlm.nih.gov/gene/?term=199990 "C1orf86, FP7162 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005272 199990 FAAP20 http://www.ncbi.nlm.nih.gov/gene/?term=199990 "C1orf86, FP7162 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005273 1999 ELF3 http://www.ncbi.nlm.nih.gov/gene/?term=1999 "EPR-1, ERT, ESE-1, ESX " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005274 199 AIF1 http://www.ncbi.nlm.nih.gov/gene/?term=199 "AIF-1, IBA1, IRT-1, IRT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005275 200014 CC2D1B http://www.ncbi.nlm.nih.gov/gene/?term=200014 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005276 200014 CC2D1B http://www.ncbi.nlm.nih.gov/gene/?term=200014 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005277 200014 CC2D1B http://www.ncbi.nlm.nih.gov/gene/?term=200014 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005278 20005 Rpl9 http://www.ncbi.nlm.nih.gov/gene/?term=20005 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005279 200081 TXLNA http://www.ncbi.nlm.nih.gov/gene/?term=200081 "IL14, TXLN " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005280 200081 TXLNA http://www.ncbi.nlm.nih.gov/gene/?term=200081 "IL14, TXLN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005281 2000 ELF4 http://www.ncbi.nlm.nih.gov/gene/?term=2000 "ELFR, MEF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005282 200162 SPAG17 http://www.ncbi.nlm.nih.gov/gene/?term=200162 "CT143, PF6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005283 200172 SLFNL1 http://www.ncbi.nlm.nih.gov/gene/?term=200172 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005284 200185 KRTCAP2 http://www.ncbi.nlm.nih.gov/gene/?term=200185 KCP2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005285 20019 Polr1a http://www.ncbi.nlm.nih.gov/gene/?term=20019 "194kDa, 3010014K16Rik, RPA194, Rpo1-4, mRPA1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005286 20019 Polr1a http://www.ncbi.nlm.nih.gov/gene/?term=20019 "194kDa, 3010014K16Rik, RPA194, Rpo1-4, mRPA1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005287 200205 IBA57 http://www.ncbi.nlm.nih.gov/gene/?term=200205 "C1orf69, MMDS3, SPG74 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005288 200205 IBA57 http://www.ncbi.nlm.nih.gov/gene/?term=200205 "C1orf69, MMDS3, SPG74 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005289 200205 IBA57 http://www.ncbi.nlm.nih.gov/gene/?term=200205 "C1orf69, MMDS3, SPG74 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005290 20020 Polr2a http://www.ncbi.nlm.nih.gov/gene/?term=20020 "220kDa, Rpb1, Rpo2-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005291 2002 ELK1 http://www.ncbi.nlm.nih.gov/gene/?term=2002 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005292 200312 RNF215 http://www.ncbi.nlm.nih.gov/gene/?term=200312 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005293 200315 APOBEC3A http://www.ncbi.nlm.nih.gov/gene/?term=200315 "A3A, ARP3, PHRBN, bK150C2.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005294 200315 APOBEC3A http://www.ncbi.nlm.nih.gov/gene/?term=200315 "A3A, ARP3, PHRBN, bK150C2.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005295 200316 APOBEC3F http://www.ncbi.nlm.nih.gov/gene/?term=200316 "A3F, ARP8, BK150C2.4.MRNA, KA6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005296 200316 APOBEC3F http://www.ncbi.nlm.nih.gov/gene/?term=200316 "A3F, ARP8, BK150C2.4.MRNA, KA6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005297 200424 TET3 http://www.ncbi.nlm.nih.gov/gene/?term=200424 hCG_40738 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005298 20042 Rps12 http://www.ncbi.nlm.nih.gov/gene/?term=20042 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005299 20042 Rps12 http://www.ncbi.nlm.nih.gov/gene/?term=20042 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005300 20044 Rps14 http://www.ncbi.nlm.nih.gov/gene/?term=20044 "2600014J02Rik, AL023078 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005301 20044 Rps14 http://www.ncbi.nlm.nih.gov/gene/?term=20044 "2600014J02Rik, AL023078 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005302 200504 GKN2 http://www.ncbi.nlm.nih.gov/gene/?term=200504 "BRICD1B, GDDR, PRO813, TFIZ1, VLTI465 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005303 20054 Rps15 http://www.ncbi.nlm.nih.gov/gene/?term=20054 rig mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005304 20055 Rps16 http://www.ncbi.nlm.nih.gov/gene/?term=20055 "AA420385, AI317031 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005305 200576 PIKFYVE http://www.ncbi.nlm.nih.gov/gene/?term=200576 "CFD, FAB1, HEL37, PIP5K, PIP5K3, ZFYVE29 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005306 2005 ELK4 http://www.ncbi.nlm.nih.gov/gene/?term=2005 SAP1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005307 200634 KRTCAP3 http://www.ncbi.nlm.nih.gov/gene/?term=200634 "KCP3, MRV222, PRO9898 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005308 200634 KRTCAP3 http://www.ncbi.nlm.nih.gov/gene/?term=200634 KCP3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005309 20068 Rps17 http://www.ncbi.nlm.nih.gov/gene/?term=20068 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005310 200728 TMEM17 http://www.ncbi.nlm.nih.gov/gene/?term=200728 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005311 200728 TMEM17 http://www.ncbi.nlm.nih.gov/gene/?term=200728 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005312 200728 TMEM17 http://www.ncbi.nlm.nih.gov/gene/?term=200728 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005313 20084 Rps18 http://www.ncbi.nlm.nih.gov/gene/?term=20084 "H-2Ke3, H2-Ke3, Ke-3, ke3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005314 20084 Rps18 http://www.ncbi.nlm.nih.gov/gene/?term=20084 "H-2Ke3, H2-Ke3, Ke-3, ke3 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005315 200879 LIPH http://www.ncbi.nlm.nih.gov/gene/?term=200879 "AH, ARWH2, HYPT7, LAH2, LPDLR, PLA1B, mPA-PLA1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005316 20088 Rps24 http://www.ncbi.nlm.nih.gov/gene/?term=20088 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005317 200894 ARL13B http://www.ncbi.nlm.nih.gov/gene/?term=200894 "ARL2L1, JBTS8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005318 200895 DHFRL1 http://www.ncbi.nlm.nih.gov/gene/?term=200895 DHFRP4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005319 20090 Rps29 http://www.ncbi.nlm.nih.gov/gene/?term=20090 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005320 200916 RPL22L1 http://www.ncbi.nlm.nih.gov/gene/?term=200916 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005321 200916 RPL22L1 http://www.ncbi.nlm.nih.gov/gene/?term=200916 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005322 200916 RPL22L1 http://www.ncbi.nlm.nih.gov/gene/?term=200916 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005323 200916 RPL22L1 http://www.ncbi.nlm.nih.gov/gene/?term=200916 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005324 20091 Rps3a1 http://www.ncbi.nlm.nih.gov/gene/?term=20091 Rps3a mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005325 200933 FBXO45 http://www.ncbi.nlm.nih.gov/gene/?term=200933 Fbx45 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005326 200933 FBXO45 http://www.ncbi.nlm.nih.gov/gene/?term=200933 Fbx45 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005327 200942 KLHDC8B http://www.ncbi.nlm.nih.gov/gene/?term=200942 CHL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005328 200942 KLHDC8B http://www.ncbi.nlm.nih.gov/gene/?term=200942 CHL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005329 200958 MUC20 http://www.ncbi.nlm.nih.gov/gene/?term=200958 MUC-20 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005330 200958 MUC20 http://www.ncbi.nlm.nih.gov/gene/?term=200958 MUC-20 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005331 20102 Rps4x http://www.ncbi.nlm.nih.gov/gene/?term=20102 "Rps4, Rps4-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005332 20102 Rps4x http://www.ncbi.nlm.nih.gov/gene/?term=20102 "Rps4, Rps4-1 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005333 20104 Rps6 http://www.ncbi.nlm.nih.gov/gene/?term=20104 S6R mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005334 2010 EMD http://www.ncbi.nlm.nih.gov/gene/?term=2010 "EDMD, LEMD5, STA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005335 20112 Rps6ka2 http://www.ncbi.nlm.nih.gov/gene/?term=20112 "90kDa, D17Wsu134e, Rps6ka-rs1, Rsk3, p90rsk, pp90rsk " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005336 201158 TVP23C http://www.ncbi.nlm.nih.gov/gene/?term=201158 FAM18B2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005337 201158 TVP23C http://www.ncbi.nlm.nih.gov/gene/?term=201158 FAM18B2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005338 20115 Rps7 http://www.ncbi.nlm.nih.gov/gene/?term=20115 "MtuA, S7, Rps7 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005339 201161 CENPV http://www.ncbi.nlm.nih.gov/gene/?term=201161 "3110013H01Rik, CENP-V, PRR6, p30 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005340 201163 FLCN http://www.ncbi.nlm.nih.gov/gene/?term=201163 "BHD, FLCL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005341 201163 FLCN http://www.ncbi.nlm.nih.gov/gene/?term=201163 "BHD, FLCL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005342 201163 FLCN http://www.ncbi.nlm.nih.gov/gene/?term=201163 "BHD, FLCL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005343 201163 FLCN http://www.ncbi.nlm.nih.gov/gene/?term=201163 "BHD, FLCL " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005344 201163 FLCN http://www.ncbi.nlm.nih.gov/gene/?term=201163 "BHD, FLCL " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005345 201164 PLD6 http://www.ncbi.nlm.nih.gov/gene/?term=201164 ZUC mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005346 201164 PLD6 http://www.ncbi.nlm.nih.gov/gene/?term=201164 ZUC mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005347 20116 Rps8 http://www.ncbi.nlm.nih.gov/gene/?term=20116 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005348 20116 Rps8 http://www.ncbi.nlm.nih.gov/gene/?term=20116 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005349 201176 ARHGAP27 http://www.ncbi.nlm.nih.gov/gene/?term=201176 "CAMGAP1, PP905, SH3D20, SH3P20 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005350 201229 LYRM9 http://www.ncbi.nlm.nih.gov/gene/?term=201229 "C17orf108, HSD24 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005351 201254 STRA13 http://www.ncbi.nlm.nih.gov/gene/?term=201254 "CENP-X, CENPX, D9, FAAP10, MHF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005352 201254 STRA13 http://www.ncbi.nlm.nih.gov/gene/?term=201254 "CENP-X, CENPX, D9, FAAP10, MHF2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005353 201255 LRRC45 http://www.ncbi.nlm.nih.gov/gene/?term=201255 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005354 201266 SLC39A11 http://www.ncbi.nlm.nih.gov/gene/?term=201266 "C17orf26, ZIP11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005355 201292 TRIM65 http://www.ncbi.nlm.nih.gov/gene/?term=201292 4732463G12Rik mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005356 201292 TRIM65 http://www.ncbi.nlm.nih.gov/gene/?term=201292 4732463G12Rik mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005357 201294 UNC13D http://www.ncbi.nlm.nih.gov/gene/?term=201294 "FHL3, HLH3, HPLH3, Munc13-4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005358 20130 Rras http://www.ncbi.nlm.nih.gov/gene/?term=20130 AI573426 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005359 20133 Rrm1 http://www.ncbi.nlm.nih.gov/gene/?term=20133 RnrM1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005360 2013 EMP2 http://www.ncbi.nlm.nih.gov/gene/?term=2013 XMP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005361 2013 EMP2 http://www.ncbi.nlm.nih.gov/gene/?term=2013 XMP mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005362 2013 EMP2 http://www.ncbi.nlm.nih.gov/gene/?term=2013 XMP mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005363 201475 RAB12 http://www.ncbi.nlm.nih.gov/gene/?term=201475 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005364 2014 EMP3 http://www.ncbi.nlm.nih.gov/gene/?term=2014 YMP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005365 201562 HACD2 http://www.ncbi.nlm.nih.gov/gene/?term=201562 PTPLB mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005366 201562 HACD2 http://www.ncbi.nlm.nih.gov/gene/?term=201562 PTPLB mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005367 201595 STT3B http://www.ncbi.nlm.nih.gov/gene/?term=201595 "CDG1X, SIMP, STT3-B " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005368 201595 STT3B http://www.ncbi.nlm.nih.gov/gene/?term=201595 "CDG1X, SIMP, STT3-B " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005369 201626 PDE12 http://www.ncbi.nlm.nih.gov/gene/?term=201626 2'-PDE mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005370 201626 PDE12 http://www.ncbi.nlm.nih.gov/gene/?term=201626 "2'-PDE, 2-PDE " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005371 201626 PDE12 http://www.ncbi.nlm.nih.gov/gene/?term=201626 "2'-PDE, 2-PDE " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005372 201626 PDE12 http://www.ncbi.nlm.nih.gov/gene/?term=201626 "2'-PDE, 2-PDE " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005373 201627 DENND6A http://www.ncbi.nlm.nih.gov/gene/?term=201627 "AFI1A, FAM116A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005374 201627 DENND6A http://www.ncbi.nlm.nih.gov/gene/?term=201627 "AFI1A, FAM116A " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005375 201627 DENND6A http://www.ncbi.nlm.nih.gov/gene/?term=201627 "AFI1A, FAM116A " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005376 20166 Rtkn http://www.ncbi.nlm.nih.gov/gene/?term=20166 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005377 20168 Rtn3 http://www.ncbi.nlm.nih.gov/gene/?term=20168 RTN3-A1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005378 201725 C4orf46 http://www.ncbi.nlm.nih.gov/gene/?term=201725 RCDG1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005379 2017 CTTN http://www.ncbi.nlm.nih.gov/gene/?term=2017 EMS1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005380 20184 Uimc1 http://www.ncbi.nlm.nih.gov/gene/?term=20184 "9430016E08Rik, D330018D10Rik, D630032M02Rik, RIP110, Rxrip110 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005381 201895 SMIM14 http://www.ncbi.nlm.nih.gov/gene/?term=201895 C4orf34 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005382 201931 TMEM192 http://www.ncbi.nlm.nih.gov/gene/?term=201931 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005383 201931 TMEM192 http://www.ncbi.nlm.nih.gov/gene/?term=201931 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005384 201931 TMEM192 http://www.ncbi.nlm.nih.gov/gene/?term=201931 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005385 20193 S100a1 http://www.ncbi.nlm.nih.gov/gene/?term=20193 "AI266795, S100, S100a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005386 20195 S100a11 http://www.ncbi.nlm.nih.gov/gene/?term=20195 "EMAPI, Emap1, S100a14, S100c, cal " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005387 201965 RWDD4 http://www.ncbi.nlm.nih.gov/gene/?term=201965 "FAM28A, RWDD4A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005388 20196 S100a13 http://www.ncbi.nlm.nih.gov/gene/?term=20196 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005389 20197 S100a3 http://www.ncbi.nlm.nih.gov/gene/?term=20197 S100E lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005390 20197 S100a3 http://www.ncbi.nlm.nih.gov/gene/?term=20197 S100E mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005391 2019 EN1 http://www.ncbi.nlm.nih.gov/gene/?term=2019 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005392 202018 TAPT1 http://www.ncbi.nlm.nih.gov/gene/?term=202018 CMVFR mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005393 202018 TAPT1 http://www.ncbi.nlm.nih.gov/gene/?term=202018 "CMVFR, OCLSBG " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005394 2020 EN2 http://www.ncbi.nlm.nih.gov/gene/?term=2020 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005395 20218 Khdrbs1 http://www.ncbi.nlm.nih.gov/gene/?term=20218 "Sam68, p62, p68 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005396 2021 ENDOG http://www.ncbi.nlm.nih.gov/gene/?term=2021 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005397 2021 ENDOG http://www.ncbi.nlm.nih.gov/gene/?term=2021 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005398 202243 CCDC125 http://www.ncbi.nlm.nih.gov/gene/?term=202243 KENAE mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005399 202243 CCDC125 http://www.ncbi.nlm.nih.gov/gene/?term=202243 KENAE mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005400 20224 Sar1a http://www.ncbi.nlm.nih.gov/gene/?term=20224 "1600019H17Rik, Sara, Sara1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005401 20229 Sat1 http://www.ncbi.nlm.nih.gov/gene/?term=20229 "AA617398, SSAT, Sat " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005402 20230 Satb1 http://www.ncbi.nlm.nih.gov/gene/?term=20230 "2610306G12Rik, AW413156 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005403 20239 Atxn2 http://www.ncbi.nlm.nih.gov/gene/?term=20239 "9630045M23Rik, ATX2, AW544490, Sca2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005404 2023 ENO1 http://www.ncbi.nlm.nih.gov/gene/?term=2023 "ENO1L1, HEL-S-17, MPB1, NNE, PPH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005405 2023 ENO1 http://www.ncbi.nlm.nih.gov/gene/?term=2023 "ENO1L1, HEL-S-17, MPB1, NNE, PPH " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005406 2023 ENO1 http://www.ncbi.nlm.nih.gov/gene/?term=2023 "ENO1L1, HEL-S-17, MPB1, NNE, PPH " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005407 20249 Scd1 http://www.ncbi.nlm.nih.gov/gene/?term=20249 "AA589638, AI265570, Scd, Scd-1, ab " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005408 20250 Scd2 http://www.ncbi.nlm.nih.gov/gene/?term=20250 "Mir5114, Scd-2, mir-5114, swty " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005409 20254 Scg2 http://www.ncbi.nlm.nih.gov/gene/?term=20254 "Chgc, SgII " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005410 20255 Scg3 http://www.ncbi.nlm.nih.gov/gene/?term=20255 "1B1075, AI385542, Chgd, SgIII " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005411 20257 Stmn2 http://www.ncbi.nlm.nih.gov/gene/?term=20257 "AI159727, SCG10, Scgn10, Stmb2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005412 20266 Scn1b http://www.ncbi.nlm.nih.gov/gene/?term=20266 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005413 20269 Scn3a http://www.ncbi.nlm.nih.gov/gene/?term=20269 "Gm1000, Nav1.3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005414 20269 Scn3a http://www.ncbi.nlm.nih.gov/gene/?term=20269 "Gm1000, Nav1.3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005415 2026 ENO2 http://www.ncbi.nlm.nih.gov/gene/?term=2026 "HEL-S-279, NSE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005416 2026 ENO2 http://www.ncbi.nlm.nih.gov/gene/?term=2026 "HEL-S-279, NSE " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005417 2026 ENO2 http://www.ncbi.nlm.nih.gov/gene/?term=2026 "HEL-S-279, NSE " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005418 2026 ENO2 http://www.ncbi.nlm.nih.gov/gene/?term=2026 "HEL-S-279, NSE " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00005419 20273 Scn8a http://www.ncbi.nlm.nih.gov/gene/?term=20273 "AI853486, C630029C19Rik, NaCh6, Nav1.6, dmu, med, mnd-2, mnd2, nmf2, nmf335, nmf58, nur14, seal " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005420 20273 Scn8a http://www.ncbi.nlm.nih.gov/gene/?term=20273 "AI853486, C630029C19Rik, NaCh6, Nav1.6, dmu, med, mnd-2, mnd2, nmf2, nmf335, nmf58, nur14, seal " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005421 20274 Scn9a http://www.ncbi.nlm.nih.gov/gene/?term=20274 "Nav1.7, PN1, mKIAA4197 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005422 20296 Ccl2 http://www.ncbi.nlm.nih.gov/gene/?term=20296 "AI323594, HC11, JE, MCAF, MCP-1, MCP1, SMC-CF, Scya2, Sigje " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005423 2029 ENSA http://www.ncbi.nlm.nih.gov/gene/?term=2029 ARPP-19e mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005424 2029 ENSA http://www.ncbi.nlm.nih.gov/gene/?term=2029 ARPP-19e mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005425 2029 ENSA http://www.ncbi.nlm.nih.gov/gene/?term=2029 ARPP-19e mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005426 202 AIM1 http://www.ncbi.nlm.nih.gov/gene/?term=202 "CRYBG1, ST4 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005427 202 AIM1 http://www.ncbi.nlm.nih.gov/gene/?term=202 "CRYBG1, ST4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005428 202 AIM1 http://www.ncbi.nlm.nih.gov/gene/?term=202 "CRYBG1, ST4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005429 20300 Ccl25 http://www.ncbi.nlm.nih.gov/gene/?term=20300 "A130072A22Rik, AI852536, CKb15, Scya25, TECK " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005430 203062 TSNARE1 http://www.ncbi.nlm.nih.gov/gene/?term=203062 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005431 203068 TUBB http://www.ncbi.nlm.nih.gov/gene/?term=203068 "CDCBM6, CSCSC1, M40, OK/SW-cl.56, TUBB1, TUBB5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005432 203068 TUBB http://www.ncbi.nlm.nih.gov/gene/?term=203068 "CDCBM6, CSCSC1, M40, OK/SW-cl.561, TUBB5, TUBB " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005433 203069 R3HCC1 http://www.ncbi.nlm.nih.gov/gene/?term=203069 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005434 203069 R3HCC1 http://www.ncbi.nlm.nih.gov/gene/?term=203069 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005435 20306 Ccl7 http://www.ncbi.nlm.nih.gov/gene/?term=20306 "MCP-3, Scya7, fic, marc, mcp3 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005436 2030 SLC29A1 http://www.ncbi.nlm.nih.gov/gene/?term=2030 ENT1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005437 2030 SLC29A1 http://www.ncbi.nlm.nih.gov/gene/?term=2030 ENT1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005438 20311 Cxcl5 http://www.ncbi.nlm.nih.gov/gene/?term=20311 "AMCF-II, Cxcl6, ENA-78, GCP-2, LIX, Scyb5, Scyb6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005439 20318 Sdf4 http://www.ncbi.nlm.nih.gov/gene/?term=20318 Cab45 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005440 203197 C9orf91 http://www.ncbi.nlm.nih.gov/gene/?term=203197 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005441 203197 C9orf91 http://www.ncbi.nlm.nih.gov/gene/?term=203197 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005442 203197 C9orf91 http://www.ncbi.nlm.nih.gov/gene/?term=203197 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005443 20320 Nptn http://www.ncbi.nlm.nih.gov/gene/?term=20320 "AW554172, SDR-1, Sdfr1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005444 203245 NAIF1 http://www.ncbi.nlm.nih.gov/gene/?term=203245 "C9orf90, bA379C10.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005445 20324 Sdpr http://www.ncbi.nlm.nih.gov/gene/?term=20324 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005446 20324 Sdpr http://www.ncbi.nlm.nih.gov/gene/?term=20324 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005447 203260 CCDC107 http://www.ncbi.nlm.nih.gov/gene/?term=203260 PSEC0222 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005448 203286 ANKS6 http://www.ncbi.nlm.nih.gov/gene/?term=203286 "ANKRD14, NPHP16, PKDR1, SAMD6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005449 203286 ANKS6 http://www.ncbi.nlm.nih.gov/gene/?term=203286 "ANKRD14, NPHP16, PKDR1, SAMD6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005450 203328 SUSD3 http://www.ncbi.nlm.nih.gov/gene/?term=203328 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005451 20334 Sec23a http://www.ncbi.nlm.nih.gov/gene/?term=20334 "Msec23, Sec23r " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005452 20336 Exoc4 http://www.ncbi.nlm.nih.gov/gene/?term=20336 "C78892, Sec8, Sec8l1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005453 2033 EP300 http://www.ncbi.nlm.nih.gov/gene/?term=2033 "KAT3B, RSTS2, p300 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005454 2033 EP300 http://www.ncbi.nlm.nih.gov/gene/?term=2033 "KAT3B, RSTS2, p300 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005455 2033 EP300 http://www.ncbi.nlm.nih.gov/gene/?term=2033 "KAT3B, RSTS2, p300 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005456 2033 EP300 http://www.ncbi.nlm.nih.gov/gene/?term=2033 "KAT3B, RSTS2, p300 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005457 20340 Glg1 http://www.ncbi.nlm.nih.gov/gene/?term=20340 "AI593353, AW537898, CFR, CFR-1, ESL-1, MG-160, MG160, Selel " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005458 203427 SLC25A43 http://www.ncbi.nlm.nih.gov/gene/?term=203427 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005459 20346 Sema3a http://www.ncbi.nlm.nih.gov/gene/?term=20346 "Hsema-I, SEMA1, SemD, Semad, coll-1 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005460 2034 EPAS1 http://www.ncbi.nlm.nih.gov/gene/?term=2034 "ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005461 2034 EPAS1 http://www.ncbi.nlm.nih.gov/gene/?term=2034 "ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005462 203522 INTS6L http://www.ncbi.nlm.nih.gov/gene/?term=203522 DDX26B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005463 20352 Sema4b http://www.ncbi.nlm.nih.gov/gene/?term=20352 "SemC, Semac, mKIAA1745 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005464 203547 VMA21 http://www.ncbi.nlm.nih.gov/gene/?term=203547 "MEAX, XMEA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005465 203547 VMA21 http://www.ncbi.nlm.nih.gov/gene/?term=203547 "MEAX, XMEA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005466 203547 VMA21 http://www.ncbi.nlm.nih.gov/gene/?term=203547 "MEAX, XMEA " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005467 203569 PAGE2 http://www.ncbi.nlm.nih.gov/gene/?term=203569 "CT16.4, GAGEC2, GAGEE2, PAGE-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005468 2035 EPB41 http://www.ncbi.nlm.nih.gov/gene/?term=2035 "4.1R, EL1, HE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005469 2035 EPB41 http://www.ncbi.nlm.nih.gov/gene/?term=2035 "4.1R, EL1, HE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005470 2035 EPB41 http://www.ncbi.nlm.nih.gov/gene/?term=2035 "4.1R, EL1, HE " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005471 2035 EPB41 http://www.ncbi.nlm.nih.gov/gene/?term=2035 "4.1R, EL1, HE " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005472 2035 EPB41 http://www.ncbi.nlm.nih.gov/gene/?term=2035 "4.1R, EL1, HE " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005473 20360 Sema6c http://www.ncbi.nlm.nih.gov/gene/?term=20360 "Semay, mKIAA1869 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005474 20361 Sema7a http://www.ncbi.nlm.nih.gov/gene/?term=20361 "2900057C09Rik, CDw108, H-Sema-L, M-Sema-L, Semal " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005475 20364 Sepw1 http://www.ncbi.nlm.nih.gov/gene/?term=20364 selW mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005476 20365 Serf1 http://www.ncbi.nlm.nih.gov/gene/?term=20365 "4F5, Msmac1, m4F5 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005477 20371 Foxp3 http://www.ncbi.nlm.nih.gov/gene/?term=20371 "JM2, scurfin, sf " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005478 20379 Sfrp4 http://www.ncbi.nlm.nih.gov/gene/?term=20379 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005479 2037 EPB41L2 http://www.ncbi.nlm.nih.gov/gene/?term=2037 "4.1-G, 4.1G " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005480 2037 EPB41L2 http://www.ncbi.nlm.nih.gov/gene/?term=2037 "4.1-G, 4.1G " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005481 2037 EPB41L2 http://www.ncbi.nlm.nih.gov/gene/?term=2037 "4.1-G, 4.1G " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005482 20384 Srsf5 http://www.ncbi.nlm.nih.gov/gene/?term=20384 Sfrs5 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005483 20384 Srsf5 http://www.ncbi.nlm.nih.gov/gene/?term=20384 Sfrs5 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005484 20387 Sftpa1 http://www.ncbi.nlm.nih.gov/gene/?term=20387 "SP-A, Sftp-1, Sftp1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005485 20390 Sftpd http://www.ncbi.nlm.nih.gov/gene/?term=20390 "AI573415, SP-D, Sftp4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005486 20394 Scg5 http://www.ncbi.nlm.nih.gov/gene/?term=20394 "7B2, AI325031, Sgne-1, Sgne1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005487 20397 Sgpl1 http://www.ncbi.nlm.nih.gov/gene/?term=20397 "AI428538, D10Xrf456, S1PL, Spl " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005488 20399 Sh2b1 http://www.ncbi.nlm.nih.gov/gene/?term=20399 "AI425885, C530001K22Rik, Irip, Psm, SH2-B, SH2-Bb, Sh2bpsm1, mKIAA1299 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005489 2039 DMTN http://www.ncbi.nlm.nih.gov/gene/?term=2039 "DMT, EPB49 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005490 2039 DMTN http://www.ncbi.nlm.nih.gov/gene/?term=2039 "DMT, EPB49 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005491 203 AK1 http://www.ncbi.nlm.nih.gov/gene/?term=203 HTL-S-58j mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005492 203 AK1 http://www.ncbi.nlm.nih.gov/gene/?term=203 HTL-S-58j mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005493 20401 Sh3bp1 http://www.ncbi.nlm.nih.gov/gene/?term=20401 3BP-1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005494 20402 Zfp106 http://www.ncbi.nlm.nih.gov/gene/?term=20402 "Cd-1, D2Dcr28, H3a, Sh3bp3, Znf106, sirm " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005495 20403 Itsn2 http://www.ncbi.nlm.nih.gov/gene/?term=20403 "AI327390, Ese2, Sh3d1B, Sh3p18, mKIAA1256 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005496 20409 Ostf1 http://www.ncbi.nlm.nih.gov/gene/?term=20409 "C78236, SH3P2, Sh3d3 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005497 2040 STOM http://www.ncbi.nlm.nih.gov/gene/?term=2040 "BND7, EPB7, EPB72 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005498 2040 STOM http://www.ncbi.nlm.nih.gov/gene/?term=2040 "BND7, EPB7, EPB72 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005499 2040 STOM http://www.ncbi.nlm.nih.gov/gene/?term=2040 "BND7, EPB7, EPB72 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005500 2040 STOM http://www.ncbi.nlm.nih.gov/gene/?term=2040 "BND7, EPB7, EPB72 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005501 20419 Shcbp1 http://www.ncbi.nlm.nih.gov/gene/?term=20419 mPAL mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005502 20425 Shmt1 http://www.ncbi.nlm.nih.gov/gene/?term=20425 "AI324848, AI385541, C81125, Shmt, mshmt, mshmt1, mshmt2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005503 20429 Shox2 http://www.ncbi.nlm.nih.gov/gene/?term=20429 "6330543G17Rik, OG12, Og12x, Prx3, SHOT " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005504 2042 EPHA3 http://www.ncbi.nlm.nih.gov/gene/?term=2042 "EK4, ETK, ETK1, HEK, HEK4, TYRO4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005505 2042 EPHA3 http://www.ncbi.nlm.nih.gov/gene/?term=2042 "EK4, ETK, ETK1, HEK, HEK4, TYRO4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005506 2042 EPHA3 http://www.ncbi.nlm.nih.gov/gene/?term=2042 "EK4, ETK, ETK1, HEK, HEK4, TYRO4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005507 20437 Siah1a http://www.ncbi.nlm.nih.gov/gene/?term=20437 "AA982064, AI853500, Sinh1a " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005508 20438 Siah1b http://www.ncbi.nlm.nih.gov/gene/?term=20438 "AA960570, Sinh1b, siah-1b " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005509 2043 EPHA4 http://www.ncbi.nlm.nih.gov/gene/?term=2043 "HEK8, SEK, TYRO1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005510 20441 St3gal3 http://www.ncbi.nlm.nih.gov/gene/?term=20441 "ST3GalIII, ST3N, Siat3, Siat6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005511 2044 EPHA5 http://www.ncbi.nlm.nih.gov/gene/?term=2044 "CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005512 20462 Tra2b http://www.ncbi.nlm.nih.gov/gene/?term=20462 "5730405G21Rik, D16Ertd266e, SIG-41, Sfrs10, Silg41, TRA2beta " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005513 20467 Sin3b http://www.ncbi.nlm.nih.gov/gene/?term=20467 2810430C10Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005514 20473 Six3 http://www.ncbi.nlm.nih.gov/gene/?term=20473 "E130112M24Rika, Six3alpha, Six3b, Six3beta, Six3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005515 20476 Six6 http://www.ncbi.nlm.nih.gov/gene/?term=20476 "Optx2, Six9 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005516 20479 Vps4b http://www.ncbi.nlm.nih.gov/gene/?term=20479 "8030489C12Rik, Skd1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005517 20482 Skil http://www.ncbi.nlm.nih.gov/gene/?term=20482 "Skir, SnoN, sno " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005518 204851 HIPK1 http://www.ncbi.nlm.nih.gov/gene/?term=204851 "Myak, Nbak2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005519 204851 HIPK1 http://www.ncbi.nlm.nih.gov/gene/?term=204851 "Myak, Nbak2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005520 204851 HIPK1 http://www.ncbi.nlm.nih.gov/gene/?term=204851 "Myak, Nbak2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005521 2048 EPHB2 http://www.ncbi.nlm.nih.gov/gene/?term=2048 "CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005522 2048 EPHB2 http://www.ncbi.nlm.nih.gov/gene/?term=2048 "CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005523 20492 Slbp http://www.ncbi.nlm.nih.gov/gene/?term=20492 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005524 20492 Slbp http://www.ncbi.nlm.nih.gov/gene/?term=20492 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005525 20494 Slc10a2 http://www.ncbi.nlm.nih.gov/gene/?term=20494 "ASBT, ISBT " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005526 2049 EPHB3 http://www.ncbi.nlm.nih.gov/gene/?term=2049 "ETK2, HEK2, TYRO6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005527 204 AK2 http://www.ncbi.nlm.nih.gov/gene/?term=204 ADK2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005528 204 AK2 http://www.ncbi.nlm.nih.gov/gene/?term=204 ADK2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005529 20501 Slc16a1 http://www.ncbi.nlm.nih.gov/gene/?term=20501 "AL022710, Mct1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005530 2050 EPHB4 http://www.ncbi.nlm.nih.gov/gene/?term=2050 "HTK, MYK1, TYRO11 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005531 2050 EPHB4 http://www.ncbi.nlm.nih.gov/gene/?term=2050 "HTK, MYK1, TYRO11 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005532 20511 Slc1a2 http://www.ncbi.nlm.nih.gov/gene/?term=20511 "1700091C19Rik, 2900019G14Rik, AI159670, Eaat2, GLT-1, GLT1, MGLT1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005533 205147 AMER3 http://www.ncbi.nlm.nih.gov/gene/?term=205147 FAM123C mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005534 20515 Slc20a1 http://www.ncbi.nlm.nih.gov/gene/?term=20515 "AI607883, Glvr-1, Glvr1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005535 2051 EPHB6 http://www.ncbi.nlm.nih.gov/gene/?term=2051 HEP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005536 2051 EPHB6 http://www.ncbi.nlm.nih.gov/gene/?term=2051 HEP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005537 205251 LINC00116 http://www.ncbi.nlm.nih.gov/gene/?term=205251 NCRNA00116 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005538 20527 Slc2a3 http://www.ncbi.nlm.nih.gov/gene/?term=20527 "AA408729, AL023014, AL024341, AU040424, C78366, Glut-3, Glut3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005539 20529 Slc31a1 http://www.ncbi.nlm.nih.gov/gene/?term=20529 "4930445G01Rik, AI787263, AU016967, Ctr1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005540 2052 EPHX1 http://www.ncbi.nlm.nih.gov/gene/?term=2052 "EPHX, EPOX, HYL1, MEH " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005541 20534 Slc4a1ap http://www.ncbi.nlm.nih.gov/gene/?term=20534 kanadaptin mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005542 20538 Slc6a2 http://www.ncbi.nlm.nih.gov/gene/?term=20538 "NE-T, NET, Slc6a5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005543 2053 EPHX2 http://www.ncbi.nlm.nih.gov/gene/?term=2053 "CEH, SEH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005544 205428 C3orf58 http://www.ncbi.nlm.nih.gov/gene/?term=205428 "DIA1, GoPro49, HASF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005545 2054 STX2 http://www.ncbi.nlm.nih.gov/gene/?term=2054 "EPIM, EPM, STX2A, STX2B, STX2C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005546 2054 STX2 http://www.ncbi.nlm.nih.gov/gene/?term=2054 "EPIM, EPMA, STX2B, STX2C, STX2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005547 2054 STX2 http://www.ncbi.nlm.nih.gov/gene/?term=2054 "EPIM, EPMA, STX2B, STX2C, STX2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005548 2054 STX2 http://www.ncbi.nlm.nih.gov/gene/?term=2054 "EPIM, EPMA, STX2B, STX2C, STX2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005549 205564 SENP5 http://www.ncbi.nlm.nih.gov/gene/?term=205564 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005550 205564 SENP5 http://www.ncbi.nlm.nih.gov/gene/?term=205564 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005551 20557 Slfn3 http://www.ncbi.nlm.nih.gov/gene/?term=20557 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005552 2055 CLN8 http://www.ncbi.nlm.nih.gov/gene/?term=2055 "C8orf61, EPMR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005553 205717 USF3 http://www.ncbi.nlm.nih.gov/gene/?term=205717 KIAA2018 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005554 205717 USF3 http://www.ncbi.nlm.nih.gov/gene/?term=205717 KIAA2018 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005555 2057 EPOR http://www.ncbi.nlm.nih.gov/gene/?term=2057 EPO-R mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005556 20585 Hltf http://www.ncbi.nlm.nih.gov/gene/?term=20585 "AF010600, BC057116, P113, Smarca3, Snf2l3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005557 20585 Hltf http://www.ncbi.nlm.nih.gov/gene/?term=20585 "AF010600, BC057116, P113, Smarca3, Snf2l3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005558 20589 Ighmbp2 http://www.ncbi.nlm.nih.gov/gene/?term=20589 "AEP, nmd, sma, Catf1, Smbp2, Smbp-2, Smubp2, RIPE3b1 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00005559 20589 Ighmbp2 http://www.ncbi.nlm.nih.gov/gene/?term=20589 "AEP, Catf1, RIPE3b1, Smbp-2, Smbp2, Smubp2, nmd, sma " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005560 20589 Ighmbp2 http://www.ncbi.nlm.nih.gov/gene/?term=20589 "AEP, Catf1, RIPE3b1, Smbp-2, Smbp2, Smubp2, nmd, sma " mRNA Mus musculus 12923260 Ribosome B cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00005561 2058 EPRS http://www.ncbi.nlm.nih.gov/gene/?term=2058 "EARS, GLUPRORS, PARS, PIG32, QARS, QPRS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005562 2058 EPRS http://www.ncbi.nlm.nih.gov/gene/?term=2058 "EARS, GLUPRORS, PARS, PIG32, QARS, QPRS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005563 2058 EPRS http://www.ncbi.nlm.nih.gov/gene/?term=2058 "EARS, GLUPRORS, PARS, PIG32, QARS, QPRS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005564 20592 Kdm5d http://www.ncbi.nlm.nih.gov/gene/?term=20592 "HY, Jarid1d, Smcy " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005565 2059 EPS8 http://www.ncbi.nlm.nih.gov/gene/?term=2059 DFNB102 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005566 20603 Sms http://www.ncbi.nlm.nih.gov/gene/?term=20603 "AI427066, Gy, SPMSY, SpmST, gyro " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005567 20605 Sstr1 http://www.ncbi.nlm.nih.gov/gene/?term=20605 "SRIF-2, SS-1-R, SS1-R, SS1R, Smstr-1, Smstr1, sst1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005568 2060 EPS15 http://www.ncbi.nlm.nih.gov/gene/?term=2060 "AF-1P, AF1P, MLLT5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005569 2060 EPS15 http://www.ncbi.nlm.nih.gov/gene/?term=2060 "AF-1P, AF1P, MLLT5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005570 2060 EPS15 http://www.ncbi.nlm.nih.gov/gene/?term=2060 "AF-1P, AF1P, MLLT5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005571 20610 Sumo3 http://www.ncbi.nlm.nih.gov/gene/?term=20610 "2810014B19Rik, D10Ertd345e, SMT3A, SUMO-3, Smt3h1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005572 20611 Ssty1 http://www.ncbi.nlm.nih.gov/gene/?term=20611 "Smy, Ssty " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005573 20614 Snap25 http://www.ncbi.nlm.nih.gov/gene/?term=20614 "Bdr, GENA70, SNAP-25, SUP, sp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005574 20614 Snap25 http://www.ncbi.nlm.nih.gov/gene/?term=20614 "Bdr, GENA70, SNAP-25, SUP, sp " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005575 20616 Snap91 http://www.ncbi.nlm.nih.gov/gene/?term=20616 "91kDa, AP180, F1-20, mKIAA0656 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005576 20618 Sncg http://www.ncbi.nlm.nih.gov/gene/?term=20618 "C79089, persyn " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005577 20619 Snap23 http://www.ncbi.nlm.nih.gov/gene/?term=20619 "23kDa, AA408749, SNAP-23, Sndt, Syndet " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005578 20620 Plk2 http://www.ncbi.nlm.nih.gov/gene/?term=20620 Snk mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005579 20623 Snrk http://www.ncbi.nlm.nih.gov/gene/?term=20623 "2010012F07Rik, AI448042, AW547029, E030034B15, R74830, mKIAA0096 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005580 20630 Snrpc http://www.ncbi.nlm.nih.gov/gene/?term=20630 "Snrp1c, U1-C, U1C " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005581 206338 LVRN http://www.ncbi.nlm.nih.gov/gene/?term=206338 "APQ, AQPEP, TAQPEP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005582 206358 SLC36A1 http://www.ncbi.nlm.nih.gov/gene/?term=206358 "Dct1, LYAAT1, PAT1, TRAMD3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005583 20639 Snrpb2 http://www.ncbi.nlm.nih.gov/gene/?term=20639 2810052G09Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005584 2063 NR2F6 http://www.ncbi.nlm.nih.gov/gene/?term=2063 "EAR-2, EAR2, ERBAL2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005585 2063 NR2F6 http://www.ncbi.nlm.nih.gov/gene/?term=2063 "EAR-2, EAR2, ERBAL2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005586 20643 Snrpe http://www.ncbi.nlm.nih.gov/gene/?term=20643 "AL022645, C76690, SME " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005587 20648 Snta1 http://www.ncbi.nlm.nih.gov/gene/?term=20648 "AW228934, Snt1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005588 2064 ERBB2 http://www.ncbi.nlm.nih.gov/gene/?term=2064 "CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005589 2064 ERBB2 http://www.ncbi.nlm.nih.gov/gene/?term=2064 "CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005590 20650 Sntb2 http://www.ncbi.nlm.nih.gov/gene/?term=20650 Snt2 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005591 20655 Sod1 http://www.ncbi.nlm.nih.gov/gene/?term=20655 "B430204E11Rik, Cu/Zn-SOD, CuZnSOD, Ipo-1, Ipo1, SODC, Sod-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005592 20658 Son http://www.ncbi.nlm.nih.gov/gene/?term=20658 "2900011L12Rik, AA409051, AU067731, C81487, mKIAA1019, nrebp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005593 2065 ERBB3 http://www.ncbi.nlm.nih.gov/gene/?term=2065 "ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005594 2065 ERBB3 http://www.ncbi.nlm.nih.gov/gene/?term=2065 "ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005595 20661 Sort1 http://www.ncbi.nlm.nih.gov/gene/?term=20661 "2900053A11Rik, AI852375, Ntr3, Ntsr3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005596 20666 Sox11 http://www.ncbi.nlm.nih.gov/gene/?term=20666 "1110038H03Rik, 6230403H02Rik, AI836553, end1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005597 20679 Sox6 http://www.ncbi.nlm.nih.gov/gene/?term=20679 "AI987981, SOX-LZ " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005598 2067 ERCC1 http://www.ncbi.nlm.nih.gov/gene/?term=2067 "COFS4, RAD10, UV20 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005599 2067 ERCC1 http://www.ncbi.nlm.nih.gov/gene/?term=2067 "COFS4, RAD10, UV20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005600 20683 Sp1 http://www.ncbi.nlm.nih.gov/gene/?term=20683 "1110003E12Rik, AA450830, AI845540-1, Sp1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005601 20683 Sp1 http://www.ncbi.nlm.nih.gov/gene/?term=20683 "1110003E12Rik, AA450830, AI845540-1, Sp1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005602 20687 Sp3 http://www.ncbi.nlm.nih.gov/gene/?term=20687 D130027J01Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005603 2068 ERCC2 http://www.ncbi.nlm.nih.gov/gene/?term=2068 "COFS2, EM9, TFIIH, TTD, TTD1, XPD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005604 20692 Sparc http://www.ncbi.nlm.nih.gov/gene/?term=20692 "BM-40, ON " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005605 2069 EREG http://www.ncbi.nlm.nih.gov/gene/?term=2069 "EPR, ER, Ep " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005606 2069 EREG http://www.ncbi.nlm.nih.gov/gene/?term=2069 "EPR, ER, Ep " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005607 2069 EREG http://www.ncbi.nlm.nih.gov/gene/?term=2069 "EPR, ER, Ep " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005608 2069 EREG http://www.ncbi.nlm.nih.gov/gene/?term=2069 "EPR, ER, Ep " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005609 207063 DHRSX http://www.ncbi.nlm.nih.gov/gene/?term=207063 "CXorf11, DHRS5X, DHRS5Y, DHRSXY, DHRSY, SDR46C1, SDR7C6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005610 207063 DHRSX http://www.ncbi.nlm.nih.gov/gene/?term=207063 "CXorf11, DHRS5X, DHRS5YY, DHRSY, SDR46C1, SDR7C6, DHRSX " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005611 2070 EYA4 http://www.ncbi.nlm.nih.gov/gene/?term=2070 "CMD1J, DFNA10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005612 2070 EYA4 http://www.ncbi.nlm.nih.gov/gene/?term=2070 "CMD1J, DFNA10 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005613 207165 Bptf http://www.ncbi.nlm.nih.gov/gene/?term=207165 "9430093H17Rik, Falz " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005614 207165 Bptf http://www.ncbi.nlm.nih.gov/gene/?term=207165 "9430093H17Rik, Falz " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005615 20717 Serpina3m http://www.ncbi.nlm.nih.gov/gene/?term=20717 "3e46, AI195004, MMCM7, MMSPi2.4, Spi-2l, Spi-2rs1, Spi2-rs1, Spi2.4, spi2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005616 207181 Rbms3 http://www.ncbi.nlm.nih.gov/gene/?term=207181 "6720477E09Rik, 8430436O14Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005617 2071 ERCC3 http://www.ncbi.nlm.nih.gov/gene/?term=2071 "BTF2, GTF2H, RAD25, TFIIH, TTD2, XPB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005618 2071 ERCC3 http://www.ncbi.nlm.nih.gov/gene/?term=2071 "BTF2, GTF2H, RAD25, TFIIH, TTD2, XPB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005619 207212 Arhgef17 http://www.ncbi.nlm.nih.gov/gene/?term=207212 "8030463K16, AI428794, AW558066, BC035332, mKIAA0337 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005620 20724 Serpinb5 http://www.ncbi.nlm.nih.gov/gene/?term=20724 "1110036M19Rik, AI462524, AI646751, Maspin, PI-5, Spi7, ovalbumin " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005621 20729 Spin1 http://www.ncbi.nlm.nih.gov/gene/?term=20729 Spin mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005622 2072 ERCC4 http://www.ncbi.nlm.nih.gov/gene/?term=2072 "ERCC11, FANCQ, RAD1, XFEPS, XPF " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005623 2072 ERCC4 http://www.ncbi.nlm.nih.gov/gene/?term=2072 "ERCC11, FANCQ, RAD1, XFEPS, XPF " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005624 207304 Hectd1 http://www.ncbi.nlm.nih.gov/gene/?term=207304 "A630086P08Rik, AI844876, b2b327Clo, opm " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005625 207393 Elfn2 http://www.ncbi.nlm.nih.gov/gene/?term=207393 "6330514E13, AW048948, BC094219, Lrrc62, Ppp1r29 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005626 2073 ERCC5 http://www.ncbi.nlm.nih.gov/gene/?term=2073 "COFS3, ERCC5-201, ERCM2, UVDR, XPG, XPGC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005627 20740 Sptan1 http://www.ncbi.nlm.nih.gov/gene/?term=20740 "2610027H02Rik, Spna-2, Spna2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005628 207425 Wdr11 http://www.ncbi.nlm.nih.gov/gene/?term=207425 "2900055P10Rik, AW489876, Brwd2, mKIAA1351 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005629 20742 Sptbn1 http://www.ncbi.nlm.nih.gov/gene/?term=20742 "9930031C03Rik, AL033301, SPTB2, Spnb-2, Spnb2, elf1, elf3, mKIAA4049 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005630 20753 Sprr1a http://www.ncbi.nlm.nih.gov/gene/?term=20753 "AI528815, SPR1a, mSPRR1A " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005631 20755 Sprr2a1 http://www.ncbi.nlm.nih.gov/gene/?term=20755 "Sprr2a, Sprr2a3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005632 207565 Camkk2 http://www.ncbi.nlm.nih.gov/gene/?term=207565 "6330570N16Rik, AW061083, mKIAA0787 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005633 207565 Camkk2 http://www.ncbi.nlm.nih.gov/gene/?term=207565 "6330570N16Rik, AW061083, mKIAA0787 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005634 207615 Wdr37 http://www.ncbi.nlm.nih.gov/gene/?term=207615 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005635 207667 Skor1 http://www.ncbi.nlm.nih.gov/gene/?term=207667 "AV273001, C230094B15Rik, Corl1, Lbxcor1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005636 20768 Sephs2 http://www.ncbi.nlm.nih.gov/gene/?term=20768 "Sps2, Ysg3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005637 20768 Sephs2 http://www.ncbi.nlm.nih.gov/gene/?term=20768 "Sps2, Ysg3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005638 20773 Sptlc2 http://www.ncbi.nlm.nih.gov/gene/?term=20773 "LCB2, LCB2a " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005639 207740 Ubald1 http://www.ncbi.nlm.nih.gov/gene/?term=207740 "1500031H01Rik, BC013706, Fam100a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005640 20775 Sqle http://www.ncbi.nlm.nih.gov/gene/?term=20775 AI323792 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005641 2077 ERF http://www.ncbi.nlm.nih.gov/gene/?term=2077 "CRS4, PE-2, PE2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005642 2077 ERF http://www.ncbi.nlm.nih.gov/gene/?term=2077 "CRS4, PE-2, PE2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005643 207818 Smagp http://www.ncbi.nlm.nih.gov/gene/?term=207818 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005644 207958 Alg11 http://www.ncbi.nlm.nih.gov/gene/?term=207958 "AI849156, AW492253, B230397C21, Mmat-4(5) " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005645 207965 Vcpkmt http://www.ncbi.nlm.nih.gov/gene/?term=207965 "Gm71, Mettl21d, Mettl221d, VCP-KMT " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005646 2079 ERH http://www.ncbi.nlm.nih.gov/gene/?term=2079 DROER mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005647 207 AKT1 http://www.ncbi.nlm.nih.gov/gene/?term=207 "AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005648 208043 Setd1b http://www.ncbi.nlm.nih.gov/gene/?term=208043 "AA516740, BC035291, KMT2G, mKIAA1076 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005649 20807 Srf http://www.ncbi.nlm.nih.gov/gene/?term=20807 "AW049942, AW240594 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005650 208092 Chmp6 http://www.ncbi.nlm.nih.gov/gene/?term=208092 2400004G01Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005651 208144 Dhx37 http://www.ncbi.nlm.nih.gov/gene/?term=208144 "Gm1050, Gm451, mKIAA1517 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005652 208146 Yeats2 http://www.ncbi.nlm.nih.gov/gene/?term=208146 "BC042768, mKIAA1197 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005653 208154 Btla http://www.ncbi.nlm.nih.gov/gene/?term=208154 A630002H24 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005654 20815 Srpk1 http://www.ncbi.nlm.nih.gov/gene/?term=20815 AU017960 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005655 20817 Srpk2 http://www.ncbi.nlm.nih.gov/gene/?term=20817 "AW226533, AW492537, AW547358, Wbp6, mSRPK2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005656 208198 Btbd2 http://www.ncbi.nlm.nih.gov/gene/?term=208198 "2610037C03Rik, 4930512K17Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005657 208228 Mob3a http://www.ncbi.nlm.nih.gov/gene/?term=208228 "5330417K06Rik, A630029F06, AV218468, Mobkl2a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005658 20822 Trove2 http://www.ncbi.nlm.nih.gov/gene/?term=20822 "1810007I17Rik, A530054J02Rik, AI646302, SS-A/Ro, Ssa, Ssa2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005659 20823 Ssb http://www.ncbi.nlm.nih.gov/gene/?term=20823 SS-B mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005660 20826 Nhp2l1 http://www.ncbi.nlm.nih.gov/gene/?term=20826 "FA-1, Fta1, Snu13, Ssfa1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005661 208292 Zfp871 http://www.ncbi.nlm.nih.gov/gene/?term=208292 "4732483N19, 9030612M13Rik, AI118577, AI265322, mKIAA3006 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005662 208292 Zfp871 http://www.ncbi.nlm.nih.gov/gene/?term=208292 "4732483N19, 9030612M13Rik, AI118577, AI265322, mKIAA3006 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005663 20840 Stac http://www.ncbi.nlm.nih.gov/gene/?term=20840 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005664 20841 Zfp143 http://www.ncbi.nlm.nih.gov/gene/?term=20841 "AA959806, AU015869, D7Ertd805e, KRAB14, SBF, Staf, Zfp79, Zfp80-rs1, Znf143, pHZ-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005665 20842 Stag1 http://www.ncbi.nlm.nih.gov/gene/?term=20842 "AU045003, SA-1, Scc3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005666 20842 Stag1 http://www.ncbi.nlm.nih.gov/gene/?term=20842 "AU045003, SA-1, Scc3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005667 20842 Stag1 http://www.ncbi.nlm.nih.gov/gene/?term=20842 "AU045003, SA-1, Scc3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005668 208439 Klhl29 http://www.ncbi.nlm.nih.gov/gene/?term=208439 "A230106N14Rik, Gm68, Kbtbd9, mKIAA1921 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005669 208440 Dip2c http://www.ncbi.nlm.nih.gov/gene/?term=208440 "2900024P20Rik, 9630044M06, mKIAA0934 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005670 208518 Cep78 http://www.ncbi.nlm.nih.gov/gene/?term=208518 "5730599I05Rik, D030027P05 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005671 208606 Rsrc2 http://www.ncbi.nlm.nih.gov/gene/?term=208606 1500011J06Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005672 208638 Slc25a38 http://www.ncbi.nlm.nih.gov/gene/?term=208638 "AV019094, BC010801 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005673 208647 Creb3l2 http://www.ncbi.nlm.nih.gov/gene/?term=208647 "BBF2H7, C530025K05Rik, SCIRR69 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005674 208650 Cblb http://www.ncbi.nlm.nih.gov/gene/?term=208650 "AI429560, AI851073, Cbl-b " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005675 208659 Fam20a http://www.ncbi.nlm.nih.gov/gene/?term=208659 AI606893 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005676 20868 Stk10 http://www.ncbi.nlm.nih.gov/gene/?term=20868 "Gek1, Lok, mKIAA4026 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005677 208718 Dis3l2 http://www.ncbi.nlm.nih.gov/gene/?term=208718 "4930429A22Rik, 8030493P09Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005678 20873 Plk4 http://www.ncbi.nlm.nih.gov/gene/?term=20873 "1700028H20, AI385771, Sak, Stk18 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005679 208748 Prrg3 http://www.ncbi.nlm.nih.gov/gene/?term=208748 Gm368 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005680 208846 Daam1 http://www.ncbi.nlm.nih.gov/gene/?term=208846 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005681 208884 Zdhhc9 http://www.ncbi.nlm.nih.gov/gene/?term=208884 "6430508G22, 9530098M12Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005682 20892 Stra13 http://www.ncbi.nlm.nih.gov/gene/?term=20892 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005683 208968 Zfp280c http://www.ncbi.nlm.nih.gov/gene/?term=208968 "BC028839, Suhw3, Zfp633, Znf280c, mKIAA1584 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005684 20897 Stra6 http://www.ncbi.nlm.nih.gov/gene/?term=20897 AI891933 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005685 208 AKT2 http://www.ncbi.nlm.nih.gov/gene/?term=208 "HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005686 20901 Strap http://www.ncbi.nlm.nih.gov/gene/?term=20901 "AW557906, C78091, C79202, Unrip " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005687 209027 Pycr1 http://www.ncbi.nlm.nih.gov/gene/?term=209027 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005688 20907 Stx1a http://www.ncbi.nlm.nih.gov/gene/?term=20907 HPC-1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005689 209091 Ccnb3 http://www.ncbi.nlm.nih.gov/gene/?term=209091 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005690 20909 Stx4a http://www.ncbi.nlm.nih.gov/gene/?term=20909 "Stx4, Syn-4, Syn4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005691 20911 Stxbp2 http://www.ncbi.nlm.nih.gov/gene/?term=20911 "C79054, Munc-18-2, Munc-18b, Munc18b, Sxtbp2, Sxtp2, Unc18-2, Unc18b, muSec1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005692 20912 Stxbp3 http://www.ncbi.nlm.nih.gov/gene/?term=20912 "Munc-18ca, Sxtbp3, Unc18-3, Stxbp3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005693 20916 Sucla2 http://www.ncbi.nlm.nih.gov/gene/?term=20916 4930547K18Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005694 20918 Eif1 http://www.ncbi.nlm.nih.gov/gene/?term=20918 Sui1-rs1 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005695 2091 FBL http://www.ncbi.nlm.nih.gov/gene/?term=2091 "FIB, FLRN, RNU3IP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005696 2091 FBL http://www.ncbi.nlm.nih.gov/gene/?term=2091 "FIB, FLRN, RNU3IP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005697 209268 Igsf1 http://www.ncbi.nlm.nih.gov/gene/?term=209268 "5330413N23, 5530402E03, AI747649, InhBP/p120, mKIAA0364 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005698 20926 Supt6 http://www.ncbi.nlm.nih.gov/gene/?term=20926 "5131400N11Rik, AI132449, SPT6h, mKIAA0162, Supt6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005699 209318 Gps1 http://www.ncbi.nlm.nih.gov/gene/?term=209318 "Cops1, Csn1, R75577, Sgn1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005700 20933 Med22 http://www.ncbi.nlm.nih.gov/gene/?term=20933 "AW212655, AW558812, Surf-5, Surf5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005701 209416 Gpkow http://www.ncbi.nlm.nih.gov/gene/?term=209416 "4432411B18, DXErtd697e, DXImx41e, T54 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005702 209446 Tfe3 http://www.ncbi.nlm.nih.gov/gene/?term=209446 "F830016E06Rik, Tcfe3, Tfe-3, bHLHe33 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005703 209462 Hace1 http://www.ncbi.nlm.nih.gov/gene/?term=209462 "1700042J16Rik, A730034A22Rik, BC025474 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005704 209478 Tbc1d12 http://www.ncbi.nlm.nih.gov/gene/?term=209478 BC033574 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005705 209558 Enpp3 http://www.ncbi.nlm.nih.gov/gene/?term=209558 "AI876438, CD203c " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005706 20964 Syn1 http://www.ncbi.nlm.nih.gov/gene/?term=20964 "Syn-1-S, Syn1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005707 209683 Ttc28 http://www.ncbi.nlm.nih.gov/gene/?term=209683 "2310015L07Rik, 6030435N04, AI428795, AI851761, BC002262, TPRBK " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005708 209737 Kif15 http://www.ncbi.nlm.nih.gov/gene/?term=209737 "3110023M17Rik, 3930402I10Rik, D330038N01, HKLP2, Knsl7, b2b1117.1Clo, b2b1117.1aClo " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005709 20979 Syt1 http://www.ncbi.nlm.nih.gov/gene/?term=20979 "AW124717, G630098F17Rik, SytI " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005710 20983 Syt4 http://www.ncbi.nlm.nih.gov/gene/?term=20983 SytIV mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005711 2098 ESD http://www.ncbi.nlm.nih.gov/gene/?term=2098 FGH mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005712 20 ABCA2 http://www.ncbi.nlm.nih.gov/gene/?term=20 ABC2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005713 210106 Papd7 http://www.ncbi.nlm.nih.gov/gene/?term=210106 "LAK-1, POLK, Pols, TRF4, TRF4-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005714 210126 Lpp http://www.ncbi.nlm.nih.gov/gene/?term=210126 "9430020K16Rik, AA959454, AU024130, B130055L10Rik, C79715, D630048H16 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005715 210126 Lpp http://www.ncbi.nlm.nih.gov/gene/?term=210126 "9430020K16Rik, AA959454, AU024130, B130055L10Rik, C79715, D630048H16 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005716 210126 Lpp http://www.ncbi.nlm.nih.gov/gene/?term=210126 "9430020K16Rik, AA959454, AU024130, B130055L10Rik, C79715, D630048H16 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005717 210135 Zfp180 http://www.ncbi.nlm.nih.gov/gene/?term=210135 "2310040I01Rik, AI852378, D130011P11, HHZ168 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005718 210148 Slc30a6 http://www.ncbi.nlm.nih.gov/gene/?term=210148 "9530029F08Rik, ZnT6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005719 210172 Zfp526 http://www.ncbi.nlm.nih.gov/gene/?term=210172 "D030024H03Rik, Znf526 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005720 210172 Zfp526 http://www.ncbi.nlm.nih.gov/gene/?term=210172 "D030024H03Rik, Znf526 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005721 2101 ESRRA http://www.ncbi.nlm.nih.gov/gene/?term=2101 "ERR1, ERRa, ERRalpha, ESRL1, NR3B1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005722 2101 ESRRA http://www.ncbi.nlm.nih.gov/gene/?term=2101 "ERR1, ERRa, ERRalpha, ESRL1, NR3B1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005723 210293 Dock10 http://www.ncbi.nlm.nih.gov/gene/?term=210293 "9330153B10Rik, A630054M16Rik, Jr4, Jr5, R75174, ZIZ3, Zizimin3, mKIAA0694 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005724 210297 Lrch2 http://www.ncbi.nlm.nih.gov/gene/?term=210297 "AI316885, mKIAA1495 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005725 210417 Thsd7b http://www.ncbi.nlm.nih.gov/gene/?term=210417 "1700074E13Rik, B930082A18, D130067I03Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005726 2104 ESRRG http://www.ncbi.nlm.nih.gov/gene/?term=2104 "ERR3, ERRgamma, NR3B3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005727 2104 ESRRG http://www.ncbi.nlm.nih.gov/gene/?term=2104 "ERR3, ERRgamma, NR3B3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005728 210529 Mettl14 http://www.ncbi.nlm.nih.gov/gene/?term=210529 "G430022H21Rik, mKIAA1627 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005729 210766 Brcc3 http://www.ncbi.nlm.nih.gov/gene/?term=210766 C6.1A mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005730 2107 ETF1 http://www.ncbi.nlm.nih.gov/gene/?term=2107 "D5S1995, ERF, ERF1, RF1, SUP45L1, TB3-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005731 2107 ETF1 http://www.ncbi.nlm.nih.gov/gene/?term=2107 "D5S1995, ERF, ERF1, RF1, SUP45L1, TB3-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005732 2107 ETF1 http://www.ncbi.nlm.nih.gov/gene/?term=2107 "D5S1995, ERF, ERF1, RF1, SUP45L1, TB3-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005733 210853 Zfp947 http://www.ncbi.nlm.nih.gov/gene/?term=210853 "6720451E15, EG210853, Gm4769 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005734 2108 ETFA http://www.ncbi.nlm.nih.gov/gene/?term=2108 "EMA, GA2, MADD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005735 2108 ETFA http://www.ncbi.nlm.nih.gov/gene/?term=2108 "EMA, GA2, MADD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005736 210973 Kbtbd2 http://www.ncbi.nlm.nih.gov/gene/?term=210973 "BC022962, Bklhd1, mKIAA1489 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005737 210982 Gltscr1l http://www.ncbi.nlm.nih.gov/gene/?term=210982 mKIAA0240 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005738 210992 Lpcat1 http://www.ncbi.nlm.nih.gov/gene/?term=210992 "2900035H07Rik, Aytl2, BB137372, BC005662, C87117, LPCAT, rd11 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005739 210998 Fam91a1 http://www.ncbi.nlm.nih.gov/gene/?term=210998 "AV220772, BC033609, D15Ertd621e, SKIN, mKIAA0493 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005740 2109 ETFB http://www.ncbi.nlm.nih.gov/gene/?term=2109 "FP585, MADD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005741 2109 ETFB http://www.ncbi.nlm.nih.gov/gene/?term=2109 "FP585, MADD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005742 210 ALAD http://www.ncbi.nlm.nih.gov/gene/?term=210 "ALADH, PBGS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005743 211006 Sepsecs http://www.ncbi.nlm.nih.gov/gene/?term=211006 "9130208G10, AA986712, D5Ertd135e, SLA, SecS " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005744 211064 Alkbh1 http://www.ncbi.nlm.nih.gov/gene/?term=211064 "2700073G19Rik, Abh, Alkbh, alkB, hABH " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005745 2110 ETFDH http://www.ncbi.nlm.nih.gov/gene/?term=2110 "ETFQO, MADD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005746 211208 Gm382 http://www.ncbi.nlm.nih.gov/gene/?term=211208 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005747 211253 Mtrf1 http://www.ncbi.nlm.nih.gov/gene/?term=211253 "A830062K05Rik, MtRF-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005748 211286 Cln5 http://www.ncbi.nlm.nih.gov/gene/?term=211286 A730075N08Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005749 211323 Nrg1 http://www.ncbi.nlm.nih.gov/gene/?term=211323 "6030402G23Rik, ARIA, D230005F13Rik, GGF, GGFII, HRG, HRGalpha, Hgl, NDF, SMDF " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005750 211389 Suox http://www.ncbi.nlm.nih.gov/gene/?term=211389 SO mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005751 211484 Tsga10 http://www.ncbi.nlm.nih.gov/gene/?term=211484 "4933432N21Rik, AI843383, Gm217, Mtsga10 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005752 211488 Ado http://www.ncbi.nlm.nih.gov/gene/?term=211488 Gm237 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005753 211496 4932415M13Rik http://www.ncbi.nlm.nih.gov/gene/?term=211496 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005754 2114 ETS2 http://www.ncbi.nlm.nih.gov/gene/?term=2114 ETS2IT1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005755 2114 ETS2 http://www.ncbi.nlm.nih.gov/gene/?term=2114 ETS2IT1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005756 211586 Tfdp2 http://www.ncbi.nlm.nih.gov/gene/?term=211586 "1110029I05Rik, A330080J22Rik, DP-3, DP3 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005757 2115 ETV1 http://www.ncbi.nlm.nih.gov/gene/?term=2115 ER81 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005758 211651 Fancd2 http://www.ncbi.nlm.nih.gov/gene/?term=211651 "2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005759 2116 ETV2 http://www.ncbi.nlm.nih.gov/gene/?term=2116 "ER71, ETSRP71 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005760 211712 Pcdh9 http://www.ncbi.nlm.nih.gov/gene/?term=211712 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005761 2117 ETV3 http://www.ncbi.nlm.nih.gov/gene/?term=2117 "METS, PE-1, PE1, bA110J1.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005762 2118 ETV4 http://www.ncbi.nlm.nih.gov/gene/?term=2118 "E1A-F, E1AF, PEA3, PEAS3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005763 211948 Pde12 http://www.ncbi.nlm.nih.gov/gene/?term=211948 "2'-PDE, E430028B21Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005764 211949 Spsb4 http://www.ncbi.nlm.nih.gov/gene/?term=211949 "D030068E18Rik, SSB-4, Ssb4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005765 2119 ETV5 http://www.ncbi.nlm.nih.gov/gene/?term=2119 ERM mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005766 2119 ETV5 http://www.ncbi.nlm.nih.gov/gene/?term=2119 ERM mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005767 211 ALAS1 http://www.ncbi.nlm.nih.gov/gene/?term=211 "ALAS, ALAS-H, ALAS3, ALASH, MIG4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005768 2120 ETV6 http://www.ncbi.nlm.nih.gov/gene/?term=2120 "TEL, TEL/ABL, THC5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005769 2120 ETV6 http://www.ncbi.nlm.nih.gov/gene/?term=2120 "TEL, TEL/ABL, THC5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005770 212114 Nhlrc3 http://www.ncbi.nlm.nih.gov/gene/?term=212114 "4833441N19, 8030451K01Rik, mKIAA4083 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005771 212127 Proser1 http://www.ncbi.nlm.nih.gov/gene/?term=212127 "2810046L04Rik, 9330161F11 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005772 212153 Ccdc191 http://www.ncbi.nlm.nih.gov/gene/?term=212153 "2610015P09Rik, 8430422M09Rik, AU040712 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005773 212198 Wdr25 http://www.ncbi.nlm.nih.gov/gene/?term=212198 B930090D16Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005774 2121 EVC http://www.ncbi.nlm.nih.gov/gene/?term=2121 "DWF-11, EVCL, EVC " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005775 2121 EVC http://www.ncbi.nlm.nih.gov/gene/?term=2121 "DWF-11, EVCL, EVC " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005776 212281 Zfp729a http://www.ncbi.nlm.nih.gov/gene/?term=212281 "A530054K11Rik, Rslcan3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005777 2122 MECOM http://www.ncbi.nlm.nih.gov/gene/?term=2122 "AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3, RUSAT2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005778 212392 Ccdc110 http://www.ncbi.nlm.nih.gov/gene/?term=212392 Gm172 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005779 212448 9330159F19Rik http://www.ncbi.nlm.nih.gov/gene/?term=212448 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005780 212483 Fam193b http://www.ncbi.nlm.nih.gov/gene/?term=212483 "IRIZIO, Kiaa1931 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005781 2124 EVI2B http://www.ncbi.nlm.nih.gov/gene/?term=2124 "CD361, D17S376, EVDB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005782 212547 Nepro http://www.ncbi.nlm.nih.gov/gene/?term=212547 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005783 212706 N4bp3 http://www.ncbi.nlm.nih.gov/gene/?term=212706 C330016O10Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005784 212728 Gm17296 http://www.ncbi.nlm.nih.gov/gene/?term=212728 "Gm179, Tarbp1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005785 212772 Arl14ep http://www.ncbi.nlm.nih.gov/gene/?term=212772 "2700007P21Rik, 4930448O08Rik, ARF7EP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005786 212862 Chpt1 http://www.ncbi.nlm.nih.gov/gene/?term=212862 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005787 212880 Ddx46 http://www.ncbi.nlm.nih.gov/gene/?term=212880 "2200005K02Rik, 8430438J23Rik, AI325430, AI957095, mKIAA0801 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005788 212892 Rsph4a http://www.ncbi.nlm.nih.gov/gene/?term=212892 "A230081C05, Rshl3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005789 212898 Dse http://www.ncbi.nlm.nih.gov/gene/?term=212898 "6030499O08, AI480506, B130024B19Rik, DS-epi1, Sart2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005790 212919 Kctd7 http://www.ncbi.nlm.nih.gov/gene/?term=212919 "4932409E18, 9430010P06Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005791 212943 Fam46a http://www.ncbi.nlm.nih.gov/gene/?term=212943 D930050G01Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005792 212 ALAS2 http://www.ncbi.nlm.nih.gov/gene/?term=212 "ALAS-E, ALASE, ANH1, ASB, XLDPP, XLEPP, XLSA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005793 213019 Pdlim2 http://www.ncbi.nlm.nih.gov/gene/?term=213019 "4732462F18Rik, Slim " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005794 213054 Gabpb2 http://www.ncbi.nlm.nih.gov/gene/?term=213054 "1810015F01Rik, 5830427M07, 9430006E19Rik, A430024B14Rik, AV050852-1, Gabpb2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005795 213081 Wdr19 http://www.ncbi.nlm.nih.gov/gene/?term=213081 "C330027H04Rik, D330023L08Rik, DYF2, Ift144, PWDMP, mKIAA1638 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005796 2130 EWSR1 http://www.ncbi.nlm.nih.gov/gene/?term=2130 "EWS, EWS-FLI1, bK984G1.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005797 2130 EWSR1 http://www.ncbi.nlm.nih.gov/gene/?term=2130 "EWS, EWS-FLI1, bK984G1.4 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005798 2130 EWSR1 http://www.ncbi.nlm.nih.gov/gene/?term=2130 "EWS, EWS-FLI1, bK984G1.4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005799 213109 Phf3 http://www.ncbi.nlm.nih.gov/gene/?term=213109 "2310061N19Rik, mKIAA0244 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005800 213119 Itga10 http://www.ncbi.nlm.nih.gov/gene/?term=213119 A630048L14 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005801 2131 EXT1 http://www.ncbi.nlm.nih.gov/gene/?term=2131 "EXT, LGCR, LGS, TRPS2, TTV " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005802 2131 EXT1 http://www.ncbi.nlm.nih.gov/gene/?term=2131 "EXT, LGCR, LGS, TRPS2, TTV " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005803 2132 EXT2 http://www.ncbi.nlm.nih.gov/gene/?term=2132 "SOTV, SSMS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005804 2132 EXT2 http://www.ncbi.nlm.nih.gov/gene/?term=2132 "SOTV, SSMS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005805 2132 EXT2 http://www.ncbi.nlm.nih.gov/gene/?term=2132 "SOTV, SSMS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005806 213311 Fbxl21 http://www.ncbi.nlm.nih.gov/gene/?term=213311 "D630045D17Rik, FBL3B, FBXL3B, Psttm " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005807 213350 Pddc1 http://www.ncbi.nlm.nih.gov/gene/?term=213350 "BC023835, D230016J19Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005808 21335 Tacc3 http://www.ncbi.nlm.nih.gov/gene/?term=21335 "Aint, C86661, Eric1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005809 21335 Tacc3 http://www.ncbi.nlm.nih.gov/gene/?term=21335 "Aint, C86661, Eric1 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00005810 213402 Armc2 http://www.ncbi.nlm.nih.gov/gene/?term=213402 2610018I05Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005811 213409 Lemd1 http://www.ncbi.nlm.nih.gov/gene/?term=213409 "4930540I23Rik, 6430514M23Rik, AI428128, LEMP-1 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005812 21340 Taf1b http://www.ncbi.nlm.nih.gov/gene/?term=21340 "4930408G01Rik, A230108M10Rik, TAFI68, Tafi86, p63 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005813 21343 Taf6 http://www.ncbi.nlm.nih.gov/gene/?term=21343 "80kDa, AW549759, TAF(II)80, TAFII70, Taf2e, p80 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005814 213452 Dstyk http://www.ncbi.nlm.nih.gov/gene/?term=213452 "A930019K20Rik, C430014H23Rik, C820013G01, Ripk5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005815 213484 Nudt18 http://www.ncbi.nlm.nih.gov/gene/?term=213484 BC036718 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005816 21353 Tank http://www.ncbi.nlm.nih.gov/gene/?term=21353 "C86182, E430026L09Rik, I-TRAF " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005817 213556 Plekhh2 http://www.ncbi.nlm.nih.gov/gene/?term=213556 "AI256725, E030001K05, mKIAA2028 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005818 21357 Tarbp2 http://www.ncbi.nlm.nih.gov/gene/?term=21357 "Prbp, TRBP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005819 2135 EXTL2 http://www.ncbi.nlm.nih.gov/gene/?term=2135 EXTR2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005820 2135 EXTL2 http://www.ncbi.nlm.nih.gov/gene/?term=2135 EXTR2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005821 21366 Slc6a6 http://www.ncbi.nlm.nih.gov/gene/?term=21366 "AA589629, C80501, Taut " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005822 213742 Xist http://www.ncbi.nlm.nih.gov/gene/?term=213742 "A430022B11, AI314753 " lncRNA Mus musculus 20833368 Nucleoplasm Fibroblast In situ hybridization "Xist RNA and hnRNP U interact and upon depletion of hnRNP U, Xist RNA is detached from the Xi and diffusely localized into the nucleoplasm. " RLID00005823 213742 Xist http://www.ncbi.nlm.nih.gov/gene/?term=213742 "A430022B11, AI314753 " lncRNA Mus musculus 11891913 Nucleus Embryo cell qRT-PCR "If this is the case, the extra Xist molecules may not be bound to the inactive X chromo-some and may, in fact, be located elsewhere in the nucleus or even in the cytoplasm. " RLID00005824 213742 Xist http://www.ncbi.nlm.nih.gov/gene/?term=213742 "A430022B11, AI314753 " lncRNA Mus musculus 12900552 Nucleus Embryonic stem cell In situ hybridization|RT-PCR "On the active male X chromosome, the XIST and TSIX genes are transcribed in undifferentiated cells of pre-implantation embryos (undifferentiated state) and then down-regulated upon cell differentiation (differentiated state). " RLID00005825 213742 Xist http://www.ncbi.nlm.nih.gov/gene/?term=213742 "A430022B11, AI314753 " lncRNA Mus musculus 16007070 Nucleus Oocyte In situ hybridization "The active and inactive X chromosomes have distinct epigenetic marks in somatic nuclei, which undergo reprogramming after transplantation into oocytes. " RLID00005826 213742 Xist http://www.ncbi.nlm.nih.gov/gene/?term=213742 "A430022B11, AI314753 " lncRNA Mus musculus 25332394 Nucleus - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/xist/ RLID00005827 213742 Xist http://www.ncbi.nlm.nih.gov/gene/?term=213742 "A430022B11, AI314753 " lncRNA Mus musculus 18625719 Nucleus Stem cell qRT-PCR Xist RNA is confined to the nuclear territory of the silenced X chromosome throughout the cell cycle. RLID00005828 213742 Xist http://www.ncbi.nlm.nih.gov/gene/?term=213742 "A430022B11, AI314753 " lncRNA Mus musculus 24462204 Nucleus Embryonic stem cell Fluorescence in situ hybridization "Using anti-GFP immunofluorescence (IF) combined with RNA fluorescence in situ hybridization (FISH), we observed an enrich- ment of Jarid2-EGFP on the Xist RNA-coated X chromosome by day 2-3 (D2/D3) of retinoic acid (RA) differentiation. " RLID00005829 213742 Xist http://www.ncbi.nlm.nih.gov/gene/?term=213742 "A430022B11, AI314753 " lncRNA Mus musculus 9069284 Nucleus Embryonic stem cell In situ hybridization The Xist gene also maps to this region and is expressed exclusively from the inactive X chromosome. Xist is unusual in that it appears not to code for a protein but produces a nuclear RNA which colocalizes with the inactive X chromosome. RLID00005830 213742 Xist http://www.ncbi.nlm.nih.gov/gene/?term=213742 "A430022B11, AI314753 " lncRNA Mus musculus 9660859 Nucleus Embryonic stem cell qRT-PCR "Mouse Xist RNA tightly localized to an active X chromosome, demonstrating for the first time that the active X chromosome in somatic cells is competent to associate with Xist RNA. " RLID00005831 213742 Xist http://www.ncbi.nlm.nih.gov/gene/?term=213742 "A430022B11, AI314753 " lncRNA Mus musculus 22817891 Nucleus Bone marrow Macrophage Next-generation sequencing "Cluster 7, for example, contains abundant transcripts in the chromatin, with much lower transcript levels in the nucleoplasm and cytoplasm relative to the other clusters. This cluster is dominated by annotated and unannotated non-coding transcripts and miRNA precursors. (The analysis excluded transcripts shorter than 400 nucleotides and therefore excluded mature miRNAs and many miRNA precursors.) Some non-coding RNAs, such as Xist, are highly enriched in the chromatin because they function at this location (Figure S2). Examples of other non-coding RNAs in Cluster 7 are Neat1 and Malat1/Neat2 (Figure S2). Further mining of the data sets may provide insights into the subcellular locations at which many non-coding RNAs function. Cluster 7 also includes transcripts from constitutive protein-coding genes that may be highly unstable and therefore present at low levels in the cytoplasm (e.g. Leng8 in Figure S2). " RLID00005832 213742 Xist http://www.ncbi.nlm.nih.gov/gene/?term=213742 "A430022B11, AI314753 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005833 213742 Xist http://www.ncbi.nlm.nih.gov/gene/?term=213742 "A430022B11, AI314753 " lncRNA Mus musculus 26190105 Nucleus Embryotem cell Microscopy "Figure 6: 3DSIM Showing that Xist RNA, Rbm15, Wtap, and Spen Co-localize within Perichromatin Spaces. Data are collected from Figure 6. " RLID00005834 213742 Xist http://www.ncbi.nlm.nih.gov/gene/?term=213742 "A430022B11, AI314753 " lncRNA Mus musculus 26464439 Axon Motoneuron In situ hybridization|qRT-PCR "We then analyzed the abundance of several lncRNAs, namely Malat1, Meg3, Rmst, Xist and Miat. All of these lncRNAs were present in the axonal compartment. " RLID00005835 21374 Tbp http://www.ncbi.nlm.nih.gov/gene/?term=21374 "GTF2D1, Gtf2d, SCA17, TFIID " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005836 213760 Prepl http://www.ncbi.nlm.nih.gov/gene/?term=213760 "2810457N15Rik, 9530014L06Rik, D030028O16Rik, mKIAA0436 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005837 213773 Tbl3 http://www.ncbi.nlm.nih.gov/gene/?term=213773 9430070M15Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005838 2137 EXTL3 http://www.ncbi.nlm.nih.gov/gene/?term=2137 "BOTV, EXTL1L, EXTR1, REGR, RPR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005839 21380 Tbx1 http://www.ncbi.nlm.nih.gov/gene/?term=21380 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005840 213819 Casd1 http://www.ncbi.nlm.nih.gov/gene/?term=213819 "Cas1, Cast1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005841 21385 Tbx2 http://www.ncbi.nlm.nih.gov/gene/?term=21385 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005842 21386 Tbx3 http://www.ncbi.nlm.nih.gov/gene/?term=21386 D5Ertd189e mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005843 213895 Bms1 http://www.ncbi.nlm.nih.gov/gene/?term=213895 "AA408648, AU020092, AU043373, BB007109, BC030906l, mKIAA0187, Bms1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005844 213948 Atg9b http://www.ncbi.nlm.nih.gov/gene/?term=213948 "Apg912, Apg9l2, Apgdc2, Gm574, Nos3as, eONE, sONE " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005845 2139 EYA2 http://www.ncbi.nlm.nih.gov/gene/?term=2139 EAB1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005846 213 ALB http://www.ncbi.nlm.nih.gov/gene/?term=213 "ANALBA, FDAH, PRO0883, PRO0903, PRO1341 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005847 21400 Tcea2 http://www.ncbi.nlm.nih.gov/gene/?term=21400 "AI326274, S-II-T1, SII-T1, Tceat " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005848 21402 Skp1a http://www.ncbi.nlm.nih.gov/gene/?term=21402 "15kDa, 2610043E24Rik, 2610206H23Rik, EMC19, OCP-II, OCP2, SKP1, Tceb1l, p19A, p19Skp1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005849 214048 Larp1b http://www.ncbi.nlm.nih.gov/gene/?term=214048 "1700108L22Rik, 4933421B21Rik, AA690246, Larp2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005850 21406 Tcf12 http://www.ncbi.nlm.nih.gov/gene/?term=21406 "A130037E08Rik, ALF1, HEB, HEBAlt, HTF-4, HTF4, ME1, REB, bHLHb20 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005851 21406 Tcf12 http://www.ncbi.nlm.nih.gov/gene/?term=21406 "A130037E08Rik, ALF1, HEB, HEBAlt, HTF-4, HTF4, ME1, REB, bHLHb20 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005852 214084 Slc18a2 http://www.ncbi.nlm.nih.gov/gene/?term=214084 "1110037L13Rik, 9330105E13, Vmat2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005853 21408 Zfp354a http://www.ncbi.nlm.nih.gov/gene/?term=21408 "AW488485, Tcf17, Znf354a, kid1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005854 2140 EYA3 http://www.ncbi.nlm.nih.gov/gene/?term=2140 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005855 2140 EYA3 http://www.ncbi.nlm.nih.gov/gene/?term=2140 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005856 2140 EYA3 http://www.ncbi.nlm.nih.gov/gene/?term=2140 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005857 21413 Tcf4 http://www.ncbi.nlm.nih.gov/gene/?term=21413 "5730422P05Rik, ASP-I2, E2-2, E2.2, ITF-2, ITF-2b, ITF2, ME2, MITF-2A, MITF-2B, SEF-2, SEF2, SEF2-1, TFE, Tcf-4, bHLHb19 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005858 21413 Tcf4 http://www.ncbi.nlm.nih.gov/gene/?term=21413 "5730422P05Rik, ASP-I2, E2-2, E2.2, ITF-2, ITF-2b, ITF2, ME2, MITF-2A, MITF-2B, SEF-2, SEF2, SEF2-1, TFE, Tcf-4, bHLHb19 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005859 214150 Ago3 http://www.ncbi.nlm.nih.gov/gene/?term=214150 "AW048688, C130014L07Rik, Eif2c3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005860 21417 Zeb1 http://www.ncbi.nlm.nih.gov/gene/?term=21417 "3110032K11Rik, AREB6, BZP, MEB1, Nil2, TCF-8, Tcf18, Tcf8, Tw, ZEB, Zfhep, Zfhx1a, Zfx1a, Zfx1ha, [delta]EF1 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005861 21417 Zeb1 http://www.ncbi.nlm.nih.gov/gene/?term=21417 "3110032K11Rik, AREB6, BZP, MEB1, Nil2, TCF-8, Tcf18, Tcf8, Tw, ZEB, Zfhep, Zfhx1a, Zfx1a, Zfx1ha, [delta]EF1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005862 21417 Zeb1 http://www.ncbi.nlm.nih.gov/gene/?term=21417 "3110032K11Rik, AREB6, BZP, MEB1, Nil2, TCF-8, Tcf18, Tcf8, Tw, ZEB, Zfhep, Zfhx1a, Zfx1a, Zfx1ha, [delta]EF1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005863 21419 Tfap2b http://www.ncbi.nlm.nih.gov/gene/?term=21419 "AI606113, AP-2(beta), E130018K07Rik, Tcfap2b " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005864 214254 Nudt15 http://www.ncbi.nlm.nih.gov/gene/?term=214254 "6530403O17, A730068G11Rik, MTH2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005865 21425 Tfeb http://www.ncbi.nlm.nih.gov/gene/?term=21425 "Tcfeb, bHLHe35 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005866 214290 Zcchc6 http://www.ncbi.nlm.nih.gov/gene/?term=214290 "6030448M23Rik, AA420405 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005867 21429 Ubtf http://www.ncbi.nlm.nih.gov/gene/?term=21429 "A930005G04Rik, NOR-90, Tcfubf, UBF, UBF-1, UBF1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005868 214308 Gm381 http://www.ncbi.nlm.nih.gov/gene/?term=214308 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005869 214444 Cdk5rap2 http://www.ncbi.nlm.nih.gov/gene/?term=214444 "2900018K03Rik, an, mKIAA1633 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005870 214459 Fnbp1l http://www.ncbi.nlm.nih.gov/gene/?term=214459 "2610318I01Rik, AW548221, TOCA1, toca-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005871 214469 Fam168b http://www.ncbi.nlm.nih.gov/gene/?term=214469 mKIAA4042 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005872 214469 Fam168b http://www.ncbi.nlm.nih.gov/gene/?term=214469 mKIAA4042 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005873 214489 BC003965 http://www.ncbi.nlm.nih.gov/gene/?term=214489 Ccsmst1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005874 21452 Tcn2 http://www.ncbi.nlm.nih.gov/gene/?term=21452 "AW208754, Tcn-2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005875 214531 Tmprss13 http://www.ncbi.nlm.nih.gov/gene/?term=214531 "BC010843, Tpmrss13 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005876 21453 Tcof1 http://www.ncbi.nlm.nih.gov/gene/?term=21453 "AA408847, AW209012, treacle " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005877 21454 Tcp1 http://www.ncbi.nlm.nih.gov/gene/?term=21454 "AI528772, CCT, Cct1, Ccta, TRic, Tcp-1, Tp63, c-cpn, p63 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005878 214580 Pstk http://www.ncbi.nlm.nih.gov/gene/?term=214580 "5430423O14Rik, 5730458D16Rik, Gm1099, R75284 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005879 214597 Sidt2 http://www.ncbi.nlm.nih.gov/gene/?term=214597 "B930096O19, BC023957, CGI-40 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005880 214663 Slc25a29 http://www.ncbi.nlm.nih.gov/gene/?term=214663 "C030003J19Rik, CACL, mCACL " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005881 2146 EZH2 http://www.ncbi.nlm.nih.gov/gene/?term=2146 "ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005882 2146 EZH2 http://www.ncbi.nlm.nih.gov/gene/?term=2146 "ENX-1, ENX1, EZH1b, KMT6, KMT6A, WVS, WVS2, EZH2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005883 214742 Rcor3 http://www.ncbi.nlm.nih.gov/gene/?term=214742 "4921514E24Rik, C730034D20Rik, E130101E15Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005884 214764 Edrf1 http://www.ncbi.nlm.nih.gov/gene/?term=214764 "2700050L05Rik, AU022667, AW558805 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005885 214804 Syde2 http://www.ncbi.nlm.nih.gov/gene/?term=214804 C430017H16Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005886 214854 Neurl3 http://www.ncbi.nlm.nih.gov/gene/?term=214854 "2010300P06Rik, Lincr " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005887 214899 Kdm5a http://www.ncbi.nlm.nih.gov/gene/?term=214899 "AA409370, C76986, Jarid1a, RBP2, Rbbp2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005888 214901 Chtf18 http://www.ncbi.nlm.nih.gov/gene/?term=214901 "6030457M03Rik, CTF18, Chl12 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005889 214951 Rhbdl1 http://www.ncbi.nlm.nih.gov/gene/?term=214951 Rhbdl mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005890 2149 F2R http://www.ncbi.nlm.nih.gov/gene/?term=2149 "CF2R, HTR, PAR-1, PAR1, TR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005891 2149 F2R http://www.ncbi.nlm.nih.gov/gene/?term=2149 "CF2R, HTR, PAR-1, PAR1, TR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005892 2149 F2R http://www.ncbi.nlm.nih.gov/gene/?term=2149 "CF2R, HTR, PAR-1, PAR1, TR " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005893 2149 F2R http://www.ncbi.nlm.nih.gov/gene/?term=2149 "CF2R, HTR, PAR-1, PAR1, TR " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005894 214 ALCAM http://www.ncbi.nlm.nih.gov/gene/?term=214 "CD166, MEMD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005895 214 ALCAM http://www.ncbi.nlm.nih.gov/gene/?term=214 "CD166, MEMD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005896 215008 Vezt http://www.ncbi.nlm.nih.gov/gene/?term=215008 "A630071D13Rik, AI848282 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005897 215031 Vgll2 http://www.ncbi.nlm.nih.gov/gene/?term=215031 "C130057C21Rik, VITO-1, Vito1, vgl-2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005898 215051 Bud13 http://www.ncbi.nlm.nih.gov/gene/?term=215051 "AV305342, D030060M11Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005899 2150 F2RL1 http://www.ncbi.nlm.nih.gov/gene/?term=2150 "GPR11, PAR2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005900 2150 F2RL1 http://www.ncbi.nlm.nih.gov/gene/?term=2150 "GPR11, PAR2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005901 215194 Kri1 http://www.ncbi.nlm.nih.gov/gene/?term=215194 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005902 2151 F2RL2 http://www.ncbi.nlm.nih.gov/gene/?term=2151 "PAR-3, PAR3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005903 2152 F3 http://www.ncbi.nlm.nih.gov/gene/?term=2152 "CD142, TF, TFA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005904 2152 F3 http://www.ncbi.nlm.nih.gov/gene/?term=2152 "CD142, TF, TFA " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00005905 215351 Senp6 http://www.ncbi.nlm.nih.gov/gene/?term=215351 "2810017C20Rik, E130319N12Rik, Susp1, mKIAA0797 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005906 215418 Csrnp1 http://www.ncbi.nlm.nih.gov/gene/?term=215418 "4931429D10Rik, Axud1, CSRNP-1, URAX1, taip-3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005907 215446 Entpd3 http://www.ncbi.nlm.nih.gov/gene/?term=215446 "Cd39l3, HB6, NTPDase-3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005908 215476 Prr14l http://www.ncbi.nlm.nih.gov/gene/?term=215476 "6030436E02Rik, C330019G07Rik, Prl14l " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005909 215476 Prr14l http://www.ncbi.nlm.nih.gov/gene/?term=215476 "6030436E02Rik, C330019G07Rik, Prl14l " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005910 215641 Mageb18 http://www.ncbi.nlm.nih.gov/gene/?term=215641 B430216B18Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005911 215690 Nav1 http://www.ncbi.nlm.nih.gov/gene/?term=215690 "9530089B19, 9930003A20Rik, C230080M11Rik, Pomfil3, Unc53h1, mKIAA1151, steerin-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005912 215693 Zmat1 http://www.ncbi.nlm.nih.gov/gene/?term=215693 "A230096A06, AW990744, B930008K04Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005913 215728 9230019H11Rik http://www.ncbi.nlm.nih.gov/gene/?term=215728 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005914 215751 Ginm1 http://www.ncbi.nlm.nih.gov/gene/?term=215751 AA589616 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005915 215789 Phactr2 http://www.ncbi.nlm.nih.gov/gene/?term=215789 "AV158170, BC012871 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005916 215798 Adgrg6 http://www.ncbi.nlm.nih.gov/gene/?term=215798 "1190004A11Rik, AI449247, AW045736, DREG, Gm222, Gpr126 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005917 2157 F8 http://www.ncbi.nlm.nih.gov/gene/?term=2157 "AHF, DXS1253E, F8B, F8C, FVIII, HEMA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005918 215866 Gm29673 http://www.ncbi.nlm.nih.gov/gene/?term=215866 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005919 216028 Lrrtm3 http://www.ncbi.nlm.nih.gov/gene/?term=216028 9630044H04Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005920 216119 Ybey http://www.ncbi.nlm.nih.gov/gene/?term=216119 "1110068N23Rik, A130042E20Rik, C21orf57, ORF57, ORF66 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005921 216154 Med16 http://www.ncbi.nlm.nih.gov/gene/?term=216154 "95kDa, A630083L04, Thrap5, Trap95 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005922 216156 Wdr18 http://www.ncbi.nlm.nih.gov/gene/?term=216156 "2310012I10Rik, AU044733, AW122032 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005923 216188 Aldh1l2 http://www.ncbi.nlm.nih.gov/gene/?term=216188 "D330038I09Rik, mtFDH " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005924 216190 Appl2 http://www.ncbi.nlm.nih.gov/gene/?term=216190 Dip3b mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005925 216197 Ckap4 http://www.ncbi.nlm.nih.gov/gene/?term=216197 "5630400A09Rik, CLIMP-63, P63 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005926 2161 F12 http://www.ncbi.nlm.nih.gov/gene/?term=2161 "HAE3, HAEX, HAF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005927 216274 Cep290 http://www.ncbi.nlm.nih.gov/gene/?term=216274 "BC004690, Nphp6, b2b1454Clo, b2b1752Clo " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005928 216292 Mettl25 http://www.ncbi.nlm.nih.gov/gene/?term=216292 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005929 2162 F13A1 http://www.ncbi.nlm.nih.gov/gene/?term=2162 F13A mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005930 216345 Zfc3h1 http://www.ncbi.nlm.nih.gov/gene/?term=216345 "BC033596, Ccdc131, Psrc2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005931 216395 Tmem5 http://www.ncbi.nlm.nih.gov/gene/?term=216395 6330415D21Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005932 216438 March9 http://www.ncbi.nlm.nih.gov/gene/?term=216438 "AI608492, BC019560 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005933 216459 Myl6b http://www.ncbi.nlm.nih.gov/gene/?term=216459 "5730437E04Rik, BC037527, MLC1SA " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005934 216527 Ccm2 http://www.ncbi.nlm.nih.gov/gene/?term=216527 BC029157 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005935 216543 Cep68 http://www.ncbi.nlm.nih.gov/gene/?term=216543 "6030463E10Rik, AI481761, BC027174, Kiaa0582 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005936 216549 Aftph http://www.ncbi.nlm.nih.gov/gene/?term=216549 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005937 216558 Ugp2 http://www.ncbi.nlm.nih.gov/gene/?term=216558 "UDPGP, UGPase " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005938 21665 Tdg http://www.ncbi.nlm.nih.gov/gene/?term=21665 "E130317C12Rik, JZA-3, Jza1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005939 2166 FAAH http://www.ncbi.nlm.nih.gov/gene/?term=2166 "FAAH-1, PSAB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005940 216739 Acsl6 http://www.ncbi.nlm.nih.gov/gene/?term=216739 "A330035H04Rik, AW050338, Facl6, LACS, Lacsl, mKIAA0837 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005941 216742 Fnip1 http://www.ncbi.nlm.nih.gov/gene/?term=216742 "A730024A03Rik, AI838773, AW557298 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005942 216760 Mfap3 http://www.ncbi.nlm.nih.gov/gene/?term=216760 "2610509F16Rik, 2700079M14Rik, AW536327 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005943 21676 Tead1 http://www.ncbi.nlm.nih.gov/gene/?term=21676 "2610024B07Rik, B230114H05Rik, Gtrgeo5, TEAD-1, TEF-1, Tcf13, mTEF-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005944 2167 FABP4 http://www.ncbi.nlm.nih.gov/gene/?term=2167 "A-FABP, AFABP, ALBP, HEL-S-104, aP2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005945 216835 Usp43 http://www.ncbi.nlm.nih.gov/gene/?term=216835 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005946 21683 Tecta http://www.ncbi.nlm.nih.gov/gene/?term=21683 Tctna mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005947 216848 Chd3 http://www.ncbi.nlm.nih.gov/gene/?term=216848 "2600010P09Rik, AF020312, Chd7, Prp7, Prp9-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005948 216853 Wrap53 http://www.ncbi.nlm.nih.gov/gene/?term=216853 "BC021790, Wdr79 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005949 216856 Nlgn2 http://www.ncbi.nlm.nih.gov/gene/?term=216856 NL2 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005950 21685 Tef http://www.ncbi.nlm.nih.gov/gene/?term=21685 2310028D20Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005951 21685 Tef http://www.ncbi.nlm.nih.gov/gene/?term=21685 2310028D20Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005952 216965 Taok1 http://www.ncbi.nlm.nih.gov/gene/?term=216965 "2810468K05Rik, AU020252, D130018F14Rik, Map3k16, Markk, Psk2, mKIAA1361 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005953 216976 BC030499 http://www.ncbi.nlm.nih.gov/gene/?term=216976 "BC037104, Sgk494 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005954 216 ALDH1A1 http://www.ncbi.nlm.nih.gov/gene/?term=216 "ALDC, ALDH-E1, ALDH1, ALDH11, HEL-9, HEL-S-53e, HEL12, PUMB1, RALDH1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005955 217011 Nle1 http://www.ncbi.nlm.nih.gov/gene/?term=217011 "AL022765, BC018399, Nle, l11Jus1, l11Jus4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005956 217031 Tada2a http://www.ncbi.nlm.nih.gov/gene/?term=217031 "AV319371, D030022J10Rik, Tada2l " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005957 217109 Utp18 http://www.ncbi.nlm.nih.gov/gene/?term=217109 "6230425C22Rik, 6430513M13, Wdr50 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005958 217124 Ppp1r9b http://www.ncbi.nlm.nih.gov/gene/?term=217124 "SPL, Spn " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005959 217124 Ppp1r9b http://www.ncbi.nlm.nih.gov/gene/?term=217124 "SPL, Spn " mRNA Mus musculus 22215810 Dendrite Hippocampus Fluorescence in situ hybridization "In order to confirm the functional consequence of the interaction between ZBP1 and its predicted target mRNAs that was observed in vivo, we investigated the dendritic localization of spinophilin (PPP1R9B) mRNA in developing hippocampal neurons using fluorescence in situ hybridization (FISH). " RLID00005960 217125 Samd14 http://www.ncbi.nlm.nih.gov/gene/?term=217125 "AI839049, AI854782, BC034054 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005961 217125 Samd14 http://www.ncbi.nlm.nih.gov/gene/?term=217125 "AI839049, AI854782, BC034054 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005962 217140 Scrn2 http://www.ncbi.nlm.nih.gov/gene/?term=217140 "AV001119, D11Moh48, SES2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005963 217166 Nr1d1 http://www.ncbi.nlm.nih.gov/gene/?term=217166 "A530070C09Rik, R75201 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005964 2171 FABP5 http://www.ncbi.nlm.nih.gov/gene/?term=2171 "E-FABP, EFABP, KFABP, PA-FABP, PAFABP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005965 2171 FABP5 http://www.ncbi.nlm.nih.gov/gene/?term=2171 "E-FABP, EFABP, KFABP, PA-FABP, PAFABP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005966 2171 FABP5 http://www.ncbi.nlm.nih.gov/gene/?term=2171 "E-FABP, EFABP, KFABP, PA-FABP, PAFABP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005967 217216 BC030867 http://www.ncbi.nlm.nih.gov/gene/?term=217216 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005968 217217 Asb16 http://www.ncbi.nlm.nih.gov/gene/?term=217217 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005969 217218 Atxn7l3 http://www.ncbi.nlm.nih.gov/gene/?term=217218 E030022H21Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005970 217232 Cdc27 http://www.ncbi.nlm.nih.gov/gene/?term=217232 "AI452358, APC3, BC023187 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005971 2172 FABP6 http://www.ncbi.nlm.nih.gov/gene/?term=2172 "I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005972 217333 Trim47 http://www.ncbi.nlm.nih.gov/gene/?term=217333 2210023F24Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005973 217366 Lrrc45 http://www.ncbi.nlm.nih.gov/gene/?term=217366 BC023296 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005974 217410 Trib2 http://www.ncbi.nlm.nih.gov/gene/?term=217410 "AW319517, TRB-2, TRB2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005975 217430 Pqlc3 http://www.ncbi.nlm.nih.gov/gene/?term=217430 "C78076, E030024M05Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005976 217480 Dgkb http://www.ncbi.nlm.nih.gov/gene/?term=217480 "6430574F24, 90kda, C630029D13Rik, DAGK2, DGK, DGK-beta, mKIAA0718 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005977 217578 Baz1a http://www.ncbi.nlm.nih.gov/gene/?term=217578 "Acf1, B930060C03, BC065123, Gtl5, Wcrf180, cbp146 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005978 217588 Mbip http://www.ncbi.nlm.nih.gov/gene/?term=217588 4933408E06Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005979 2175 FANCA http://www.ncbi.nlm.nih.gov/gene/?term=2175 "FA, FA-H, FA1, FAA, FACA, FAH, FANCH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005980 2175 FANCA http://www.ncbi.nlm.nih.gov/gene/?term=2175 "FA, FA-H, FA1, FAA, FACA, FAH, FANCH " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00005981 217601 BC042761 http://www.ncbi.nlm.nih.gov/gene/?term=217601 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005982 21761 Morf4l1 http://www.ncbi.nlm.nih.gov/gene/?term=21761 "MORFRG15, MRG15, TEG-189, Tex189, mKIAA4002 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005983 21761 Morf4l1 http://www.ncbi.nlm.nih.gov/gene/21761 mRNA Mus musculus 11985882 Dendrite pyramidal cell In situ hybridization "The findings indicate that CPER9 was actually localized at the apical dendrites of a portion of cerebral cortex layer V pyramidal cells, as well as at the proximal dendrites of some of the cerebellar Purkinje cells. CPER9 was found to encode a mouse homolog of MRG15, a nuclear protein which contains a chromodomain identified in several proteins that act as regulators of transcription. " RLID00005984 217664 Mgat2 http://www.ncbi.nlm.nih.gov/gene/?term=217664 "AA407964, CDGS2, GLCNACTII, GNT-II, GNT2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005985 21766 Tex261 http://www.ncbi.nlm.nih.gov/gene/?term=21766 "3110001O07Rik, AA409339, AI480706, AL033351, TEG-261 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005986 217692 Sipa1l1 http://www.ncbi.nlm.nih.gov/gene/?term=217692 "4931426N11Rik, AW213287, Spar, mKIAA0440 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005987 21769 Zfand3 http://www.ncbi.nlm.nih.gov/gene/?term=21769 "AW539211, TEG-27, Tex27 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005988 217718 Nek9 http://www.ncbi.nlm.nih.gov/gene/?term=217718 C130021H08Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005989 217732 Cipc http://www.ncbi.nlm.nih.gov/gene/?term=217732 "2310044G17Rik, AI842544, AI853744, Kiaa1737, mKIAA1737 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005990 217734 Pomt2 http://www.ncbi.nlm.nih.gov/gene/?term=217734 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005991 2177 FANCD2 http://www.ncbi.nlm.nih.gov/gene/?term=2177 "FA-D2, FA4, FACD, FAD, FAD2, FANCD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00005992 2177 FANCD2 http://www.ncbi.nlm.nih.gov/gene/?term=2177 "FA-D2, FA4, FACD, FAD, FAD2, FANCD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00005993 21780 Tfam http://www.ncbi.nlm.nih.gov/gene/?term=21780 "AI661103, Hmgts, mtTFA, tsHMG " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005994 217843 Unc79 http://www.ncbi.nlm.nih.gov/gene/?term=217843 "9030205A07Rik, Mlca3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005995 217864 Rcor1 http://www.ncbi.nlm.nih.gov/gene/?term=217864 "5730409O11, 6720480E22Rik, AU042633, D12Wsu95e, Rocr1, mKIAA0071 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005996 217869 Eif5 http://www.ncbi.nlm.nih.gov/gene/?term=217869 "2810011H21Rik, D12Ertd549e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005997 217869 Eif5 http://www.ncbi.nlm.nih.gov/gene/?term=217869 "2810011H21Rik, D12Ertd549e " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00005998 21788 Tfpi http://www.ncbi.nlm.nih.gov/gene/?term=21788 "A630013F22Rik, AW552122, EPI, LACI " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00005999 2178 FANCE http://www.ncbi.nlm.nih.gov/gene/?term=2178 "FACE, FAE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006000 217944 Rapgef5 http://www.ncbi.nlm.nih.gov/gene/?term=217944 "4932413M22, C86120, D030051B22Rik, GFR, Mrgef, mKIAA0277, mmr-gef " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006001 217946 Cdca7l http://www.ncbi.nlm.nih.gov/gene/?term=217946 "BC006933, JPO2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006002 217980 Larp4b http://www.ncbi.nlm.nih.gov/gene/?term=217980 "A630096F19, AI256361, D13Wsu64e, Larp5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006003 217980 Larp4b http://www.ncbi.nlm.nih.gov/gene/?term=217980 "A630096F19, AI256361, D13Wsu64e, Larp5 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006004 217995 Heatr1 http://www.ncbi.nlm.nih.gov/gene/?term=217995 "AA517551, B130016L12Rik, BC019693 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006005 218035 Vps41 http://www.ncbi.nlm.nih.gov/gene/?term=218035 "AI317346, Vam2, mVam2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006006 21803 Tgfb1 http://www.ncbi.nlm.nih.gov/gene/?term=21803 "TGF-beta1, TGFbeta1, Tgfb, Tgfb-1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006007 21804 Tgfb1i1 http://www.ncbi.nlm.nih.gov/gene/?term=21804 "ARA55, Hic5, TSC-5, hic-5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006008 21808 Tgfb2 http://www.ncbi.nlm.nih.gov/gene/?term=21808 "BB105277, Tgf-beta2, Tgfb-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006009 2180 ACSL1 http://www.ncbi.nlm.nih.gov/gene/?term=2180 "ACS1, FACL1, FACL2, LACS, LACS1, LACS2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006010 2180 ACSL1 http://www.ncbi.nlm.nih.gov/gene/?term=2180 "ACS1, FACL1, FACL2, LACS, LACS1, LACS2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006011 2180 ACSL1 http://www.ncbi.nlm.nih.gov/gene/?term=2180 "ACS1, FACL1, FACL2, LACS, LACS1, LACS2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006012 218100 Zfp322a http://www.ncbi.nlm.nih.gov/gene/?term=218100 "Znf322, Znf322a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006013 21812 Tgfbr1 http://www.ncbi.nlm.nih.gov/gene/?term=21812 "ALK5, AU017191, Alk-5, ESK2, TGFR-1, TbetaR-I, TbetaRI " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006014 2181 ACSL3 http://www.ncbi.nlm.nih.gov/gene/?term=2181 "ACS3, FACL3, PRO2194 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006015 2181 ACSL3 http://www.ncbi.nlm.nih.gov/gene/?term=2181 "ACS3, FACL3, PRO2194 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006016 2181 ACSL3 http://www.ncbi.nlm.nih.gov/gene/?term=2181 "ACS3, FACL3, PRO2194 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006017 218210 Nup153 http://www.ncbi.nlm.nih.gov/gene/?term=218210 "B130015D15Rik, C88147 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006018 218214 Kdm1b http://www.ncbi.nlm.nih.gov/gene/?term=218214 "4632428N09Rik, AI482520, Aof1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006019 21821 Ift88 http://www.ncbi.nlm.nih.gov/gene/?term=21821 "AW552028, Tg737, Tg737Rpw, TgN737Rpw, Ttc10, flexo, fxo, orpk, polaris " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006020 21822 Tgtp1 http://www.ncbi.nlm.nih.gov/gene/?term=21822 "Gtp2, Irgb6, Mg21, Tgtp " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006021 218236 Fam120a http://www.ncbi.nlm.nih.gov/gene/?term=218236 "C9orf10, Ossa " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006022 21823 Th http://www.ncbi.nlm.nih.gov/gene/?term=21823 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006023 21827 Thbs3 http://www.ncbi.nlm.nih.gov/gene/?term=21827 "TSP3, Thbs-3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006024 218294 Cdc14b http://www.ncbi.nlm.nih.gov/gene/?term=218294 "2810432N10Rik, A530086E13Rik, AA472821, CDC14B3, Cdc14B1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006025 218294 Cdc14b http://www.ncbi.nlm.nih.gov/gene/?term=218294 "2810432N10Rik, A530086E13Rik, AA472821, CDC14B3, Cdc14B1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006026 2182 ACSL4 http://www.ncbi.nlm.nih.gov/gene/?term=2182 "ACS4, FACL4, LACS4, MRX63, MRX68 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006027 218311 Zfp455 http://www.ncbi.nlm.nih.gov/gene/?term=218311 "3732412P20Rik, Rslcan-10 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006028 218314 Zfp595 http://www.ncbi.nlm.nih.gov/gene/?term=218314 "A230042K10Rik, Rslcan23 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006029 218333 Ice1 http://www.ncbi.nlm.nih.gov/gene/?term=218333 "C77245, mKIAA0947 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006030 21833 Thra http://www.ncbi.nlm.nih.gov/gene/?term=21833 "6430529J03Rik, AW259572, Erba, Nr1a1, Rvr, T3R[a], T3Ralpha1, Thra2, c-erbA-1, c-erbA-alpha, c-erbAalpha, Thra " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006031 218341 Rfesd http://www.ncbi.nlm.nih.gov/gene/?term=218341 "AI256775, D030068K09 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006032 218397 Rasa1 http://www.ncbi.nlm.nih.gov/gene/?term=218397 "Gap, RasGAP, Rasa " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006033 218397 Rasa1 http://www.ncbi.nlm.nih.gov/gene/?term=218397 "Gap, RasGAP, Rasa " mRNA Mus musculus 24381269 Axon Dorsal root ganglia qRT-PCR "Using qRT-PCR, we confirmed the presence of Rasa1 mRNA in isolated DRG axons. " RLID00006034 21841 Tia1 http://www.ncbi.nlm.nih.gov/gene/?term=21841 "2310050N03Rik, AI256674, TIA-1, mTIA-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006035 21843 Tial1 http://www.ncbi.nlm.nih.gov/gene/?term=21843 "5330433G13Rik, AL033329, TIAR, mTIAR " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006036 21844 Tiam1 http://www.ncbi.nlm.nih.gov/gene/?term=21844 "AI847750, D16Ium10, D16Ium10e " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006037 21848 Trim24 http://www.ncbi.nlm.nih.gov/gene/?term=21848 "A130082H20Rik, AI447469, D430004I05Rik, TIF1, TIF1-alpha, TIF1alpha, Tif1a " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006038 21849 Trim28 http://www.ncbi.nlm.nih.gov/gene/?term=21849 "AA408787, KAP-1, KRIP-1, MommeD9, Tif1b, Tif1beta " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006039 2184 FAH http://www.ncbi.nlm.nih.gov/gene/?term=2184 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006040 218518 Marveld2 http://www.ncbi.nlm.nih.gov/gene/?term=218518 "BC003296, MARVD2, Mrvldc2, Tric, Trica, Tricb, Tricc " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006041 218543 Srek1 http://www.ncbi.nlm.nih.gov/gene/?term=218543 "8430401B01, AI450757, AI462342, SRrp508, SRrp86, Sfrs12, Srsf12 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006042 218544 Sgtb http://www.ncbi.nlm.nih.gov/gene/?term=218544 C630001O05Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006043 21855 Timm17b http://www.ncbi.nlm.nih.gov/gene/?term=21855 "17kDa, Sfc3, mTim17b " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006044 218581 Depdc1b http://www.ncbi.nlm.nih.gov/gene/?term=218581 "9830132O03, AW260467, XTP1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006045 218629 Dhx29 http://www.ncbi.nlm.nih.gov/gene/?term=218629 "3732415M03, AU043276, Ddxx, E130202M19Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006046 218693 Paip1 http://www.ncbi.nlm.nih.gov/gene/?term=218693 PAIP-1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006047 2186 BPTF http://www.ncbi.nlm.nih.gov/gene/?term=2186 "FAC1, FALZ, NURF301 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006048 2186 BPTF http://www.ncbi.nlm.nih.gov/gene/?term=2186 "FAC1, FALZ, NURF301 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006049 2186 BPTF http://www.ncbi.nlm.nih.gov/gene/?term=2186 "FAC1, FALZ, NURF301 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006050 218756 Slc4a7 http://www.ncbi.nlm.nih.gov/gene/?term=218756 "E430014N10Rik, NBC3, NBCn1, NBCn1-G " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006051 21885 Tle1 http://www.ncbi.nlm.nih.gov/gene/?term=21885 "C230057C06Rik, Estm14, Grg-1, Grg1, Tle4l " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006052 21888 Tle4 http://www.ncbi.nlm.nih.gov/gene/?term=21888 "5730411M05Rik, AA792082, Bce-1, Bce1, ESTM13, ESTM14, Grg4, X83332, X83333, grg-4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006053 2188 FANCF http://www.ncbi.nlm.nih.gov/gene/?term=2188 FAF mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006054 2188 FANCF http://www.ncbi.nlm.nih.gov/gene/?term=2188 FAF mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006055 218914 Wapl http://www.ncbi.nlm.nih.gov/gene/?term=218914 "A530089A20Rik, BC037674, DIF-2, FOE, Wapal " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006056 2189 FANCG http://www.ncbi.nlm.nih.gov/gene/?term=2189 "FAG, XRCC9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006057 2189 FANCG http://www.ncbi.nlm.nih.gov/gene/?term=2189 "FAG, XRCC9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006058 2189 FANCG http://www.ncbi.nlm.nih.gov/gene/?term=2189 "FAG, XRCC9 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006059 218 ALDH3A1 http://www.ncbi.nlm.nih.gov/gene/?term=218 "ALDH3, ALDHIII " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006060 219103 Cenpj http://www.ncbi.nlm.nih.gov/gene/?term=219103 "4932437H03Rik, CPAP, Gm81, LAP, LIP1, Sas4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006061 219131 Phf11a http://www.ncbi.nlm.nih.gov/gene/?term=219131 "4933417L10Rik, Phf11, Phf11l " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006062 219144 Arl11 http://www.ncbi.nlm.nih.gov/gene/?term=219144 "ARLTS1, C730007L20Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006063 2191 FAP http://www.ncbi.nlm.nih.gov/gene/?term=2191 "DPPIV, FAPA, SIMP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006064 219228 Pcdh17 http://www.ncbi.nlm.nih.gov/gene/?term=219228 "C030033F14Rik, Gm78 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006065 219249 Tdrd3 http://www.ncbi.nlm.nih.gov/gene/?term=219249 "4732418C03Rik, 6720468N18 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006066 219257 Pcdh20 http://www.ncbi.nlm.nih.gov/gene/?term=219257 "C630015B17Rik, Pcdh13 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006067 219293 ATAD3C http://www.ncbi.nlm.nih.gov/gene/?term=219293 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006068 219293 ATAD3C http://www.ncbi.nlm.nih.gov/gene/?term=219293 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006069 219333 USP12 http://www.ncbi.nlm.nih.gov/gene/?term=219333 "UBH1, USP12L1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006070 21934 Tnfrsf11a http://www.ncbi.nlm.nih.gov/gene/?term=21934 "Ly109, ODFR, OFE, Rank, TRANCE-R, mRANK " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006071 21938 Tnfrsf1b http://www.ncbi.nlm.nih.gov/gene/?term=21938 "CD120b, TNF-R-II, TNF-R2, TNF-R75, TNF-alphaR2, TNFBR, TNFR80, TNFRII, TNFalpha-R2, Tnfr-1, Tnfr2, p75 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006072 2193 FARSA http://www.ncbi.nlm.nih.gov/gene/?term=2193 "CML33, FARSL, FARSLA, FRSA, PheHA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006073 2193 FARSA http://www.ncbi.nlm.nih.gov/gene/?term=2193 "CML33, FARSL, FARSLA, FRSA, PheHA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006074 2193 FARSA http://www.ncbi.nlm.nih.gov/gene/?term=2193 "CML33, FARSL, FARSLA, FRSA, PheHA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006075 219402 MTIF3 http://www.ncbi.nlm.nih.gov/gene/?term=219402 IF3mt mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006076 219402 MTIF3 http://www.ncbi.nlm.nih.gov/gene/?term=219402 IF3mt mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006077 21940 Cd27 http://www.ncbi.nlm.nih.gov/gene/?term=21940 "S152, Tnfrsf7, Tp55 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006078 2194 FASN http://www.ncbi.nlm.nih.gov/gene/?term=2194 "FAS, OA-519, SDR27X1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006079 2194 FASN http://www.ncbi.nlm.nih.gov/gene/?term=2194 "FAS, OA-519, SDR27X1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006080 219539 YPEL4 http://www.ncbi.nlm.nih.gov/gene/?term=219539 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006081 219557 C7orf62 http://www.ncbi.nlm.nih.gov/gene/?term=219557 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006082 2195 FAT1 http://www.ncbi.nlm.nih.gov/gene/?term=2195 "CDHF7, CDHR8, FAT, ME5, hFat1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006083 2195 FAT1 http://www.ncbi.nlm.nih.gov/gene/?term=2195 "CDHF7, CDHR8, FAT, ME5, hFat1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006084 21969 Top1 http://www.ncbi.nlm.nih.gov/gene/?term=21969 "AI467334, D130064I21Rik, Top-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006085 2196 FAT2 http://www.ncbi.nlm.nih.gov/gene/?term=2196 "CDHF8, CDHR9, HFAT2, MEGF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006086 219736 STOX1 http://www.ncbi.nlm.nih.gov/gene/?term=219736 "C10orf24, PEE4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006087 21973 Top2a http://www.ncbi.nlm.nih.gov/gene/?term=21973 Top-2 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006088 219743 TYSND1 http://www.ncbi.nlm.nih.gov/gene/?term=219743 NET41 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006089 219743 TYSND1 http://www.ncbi.nlm.nih.gov/gene/?term=219743 NET41 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006090 219743 TYSND1 http://www.ncbi.nlm.nih.gov/gene/?term=219743 NET41 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006091 21974 Top2b http://www.ncbi.nlm.nih.gov/gene/?term=21974 "D230016L12Rik, Top-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006092 219771 CCNY http://www.ncbi.nlm.nih.gov/gene/?term=219771 "C10orf9, CBCP1, CCNX, CFP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006093 219771 CCNY http://www.ncbi.nlm.nih.gov/gene/?term=219771 "C10orf9, CBCP1, CCNX, CFP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006094 219790 RTKN2 http://www.ncbi.nlm.nih.gov/gene/?term=219790 "PLEKHK1, bA531F24.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006095 2197 FAU http://www.ncbi.nlm.nih.gov/gene/?term=2197 "FAU1, Fub1, Fubi, MNSFbeta, RPS30, S30, asr1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006096 2197 FAU http://www.ncbi.nlm.nih.gov/gene/?term=2197 "FAU1, Fub1, Fubi, MNSFbeta, RPS30, S30, asr1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006097 2197 FAU http://www.ncbi.nlm.nih.gov/gene/?term=2197 "FAU1, Fub1, Fubi, MNSFbeta, RPS30, S30, asr1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006098 21982 Tmem165 http://www.ncbi.nlm.nih.gov/gene/?term=21982 "AV026557, Tpardl, Tparl, pFT27 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006099 219854 TMEM218 http://www.ncbi.nlm.nih.gov/gene/?term=219854 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006100 219899 TBCEL http://www.ncbi.nlm.nih.gov/gene/?term=219899 "El, LRRC35 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006101 219902 TMEM136 http://www.ncbi.nlm.nih.gov/gene/?term=219902 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006102 21990 Tph1 http://www.ncbi.nlm.nih.gov/gene/?term=21990 Tph mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006103 219927 MRPL21 http://www.ncbi.nlm.nih.gov/gene/?term=219927 "L21mt, MRP-L21 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006104 219927 MRPL21 http://www.ncbi.nlm.nih.gov/gene/?term=219927 "L21mt, MRP-L21 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006105 219988 PATL1 http://www.ncbi.nlm.nih.gov/gene/?term=219988 "Pat1b, hPat1b " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006106 219988 PATL1 http://www.ncbi.nlm.nih.gov/gene/?term=219988 "Pat1b, hPat1b " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006107 219988 PATL1 http://www.ncbi.nlm.nih.gov/gene/?term=219988 "Pat1b, hPat1b " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006108 2199 FBLN2 http://www.ncbi.nlm.nih.gov/gene/?term=2199 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006109 219 ALDH1B1 http://www.ncbi.nlm.nih.gov/gene/?term=219 "ALDH5, ALDHX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006110 219 ALDH1B1 http://www.ncbi.nlm.nih.gov/gene/?term=219 "ALDH5, ALDHX " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006111 219 ALDH1B1 http://www.ncbi.nlm.nih.gov/gene/?term=219 "ALDH5, ALDHX " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006112 219 ALDH1B1 http://www.ncbi.nlm.nih.gov/gene/?term=219 "ALDH5, ALDHX " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006113 21 ABCA3 http://www.ncbi.nlm.nih.gov/gene/?term=21 "ABC-C, ABC3, EST111653, LBM180, SMDP3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006114 220002 CYB561A3 http://www.ncbi.nlm.nih.gov/gene/?term=220002 "CYBASC3, LCYTB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006115 22003 Tpm1 http://www.ncbi.nlm.nih.gov/gene/?term=22003 "AA986836, AI854628, TM2, Tm3, Tmpa, Tpm-1, alpha-TM " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00006116 220064 ORAOV1 http://www.ncbi.nlm.nih.gov/gene/?term=220064 TAOS1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006117 220064 ORAOV1 http://www.ncbi.nlm.nih.gov/gene/?term=220064 TAOS1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006118 220074 LRTOMT http://www.ncbi.nlm.nih.gov/gene/?term=220074 "CFAP111, DFNB63, LRRC51 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006119 220074 LRTOMT http://www.ncbi.nlm.nih.gov/gene/?term=220074 "CFAP111, DFNB63, LRRC51 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006120 220074 LRTOMT http://www.ncbi.nlm.nih.gov/gene/?term=220074 "CFAP111, DFNB63, LRRC51 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006121 220074 LRTOMT http://www.ncbi.nlm.nih.gov/gene/?term=220074 "CFAP111, DFNB63, LRRC51 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006122 2200 FBN1 http://www.ncbi.nlm.nih.gov/gene/?term=2200 "ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006123 220134 SKA1 http://www.ncbi.nlm.nih.gov/gene/?term=220134 C18orf24 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006124 220134 SKA1 http://www.ncbi.nlm.nih.gov/gene/?term=220134 C18orf24 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006125 220134 SKA1 http://www.ncbi.nlm.nih.gov/gene/?term=220134 C18orf24 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006126 220134 SKA1 http://www.ncbi.nlm.nih.gov/gene/?term=220134 C18orf24 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006127 220164 DOK6 http://www.ncbi.nlm.nih.gov/gene/?term=220164 "DOK5L, HsT3226 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006128 22019 Tpp2 http://www.ncbi.nlm.nih.gov/gene/?term=22019 "TPP-2, TppII " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006129 2201 FBN2 http://www.ncbi.nlm.nih.gov/gene/?term=2201 "CCA, DA9, EOMD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006130 220213 OTUD1 http://www.ncbi.nlm.nih.gov/gene/?term=220213 "DUBA7, OTDC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006131 22021 Tpst1 http://www.ncbi.nlm.nih.gov/gene/?term=22021 "R75054, Tango13a " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006132 22026 Nr2c2 http://www.ncbi.nlm.nih.gov/gene/?term=22026 "TAK1, Tr4, mKIAA4145 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006133 22026 Nr2c2 http://www.ncbi.nlm.nih.gov/gene/?term=22026 "TAK1, Tr4, mKIAA4145 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006134 22027 Hsp90b1 http://www.ncbi.nlm.nih.gov/gene/?term=22027 "TA-3, Tra1, gp96, ERp99, GRP94, Targ2, Tra-1, endoplasmin " mRNA Mus musculus 12923260 Ribosome J558 cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00006135 22027 Hsp90b1 http://www.ncbi.nlm.nih.gov/gene/?term=22027 "ERp99, GRP94, TA-3, Targ2, Tra-1, Tra1, endoplasmin, gp96 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006136 22027 Hsp90b1 http://www.ncbi.nlm.nih.gov/gene/?term=22027 "ERp99, GRP94, TA-3, Targ2, Tra-1, Tra1, endoplasmin, gp96 " mRNA Mus musculus 12923260 Endoplasmic reticulum B cell Northern blot "Oligonucleotide probes were designed to hybridize with mRNAs encoding representative members of three classes of protein: soluble (GAPDH, Hsp90, and LDH), ER resident membrane (Sec61α and calnexin), and ER resident lumenal (BiP, calreticulin, and GRP94). " RLID00006137 22027 Hsp90b1 http://www.ncbi.nlm.nih.gov/gene/?term=22027 "ERp99, GRP94, TA-3, Targ2, Tra-1, Tra1, endoplasmin, gp96 " mRNA Mus musculus 12923260 Endoplasmic reticulum NIH-3T3 Fibroblast In situ hybridization "For these experiments, three mRNAs were examined: that encoding GRP94, which is highly enriched in the ER membrane fraction of fractionated cells; GAPDH, which displays a predominately (but not uniquely) soluble enrichment; and Hsp90, which displays noncanonical partitioning on the ER. Experiments were performed using NIH-3T3 fibroblasts and digoxygenin-labeled antisense RNA probes, with optical sections obtained by widefield microscopy.As expected, mRNAs encoding GRP94 display a typical, perinuclear and reticular ER pattern (Fig. 6A), with the ImageJ rendering providing a graphical display of the perinuclear, ER partitioning of this mRNA species (Fig. 6A, far right panel). " RLID00006138 22027 Hsp90b1 http://www.ncbi.nlm.nih.gov/gene/?term=22027 "ERp99, GRP94, TA-3, Targ2, Tra-1, Tra1, endoplasmin, gp96 " mRNA Mus musculus 12923260 Ribosome B cell S1 nuclease protection assays "Using the procedures described above, the subcellular distribution of individual mRNAs in the cytosol and rough ER polysome fractions of Jurkat and J558 cells was determined. mRNAs for resident proteins of the ER lumen, including BiP, calreticulin, and GRP94, were also highly enriched on membrane-bound polysomes. " RLID00006139 2202 EFEMP1 http://www.ncbi.nlm.nih.gov/gene/?term=2202 "DHRD, DRAD, FBLN3, FBNL, FIBL-3, MLVT, MTLV, S1-5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006140 22031 Traf3 http://www.ncbi.nlm.nih.gov/gene/?term=22031 "AI528849, CAP-1, CD40bp, CRAF1, LAP1, T-BAM, amn " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006141 220323 OAF http://www.ncbi.nlm.nih.gov/gene/?term=220323 NS5ATP13TP2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006142 220323 OAF http://www.ncbi.nlm.nih.gov/gene/?term=220323 NS5ATP13TP2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006143 22032 Traf4 http://www.ncbi.nlm.nih.gov/gene/?term=22032 "A530032M13Rik, CART1, msp2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006144 22034 Traf6 http://www.ncbi.nlm.nih.gov/gene/?term=22034 "2310003F17Rik, AI851288, C630032O20Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006145 220359 TIGD3 http://www.ncbi.nlm.nih.gov/gene/?term=220359 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006146 22042 Tfrc http://www.ncbi.nlm.nih.gov/gene/?term=22042 "2610028K12Rik, CD71, E430033M20Rik, Mtvr1, TFR, TFR1, TR, Trfr, p90 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006147 22042 Tfrc http://www.ncbi.nlm.nih.gov/gene/?term=22042 "2610028K12Rik, CD71, E430033M20Rik, Mtvr1, TFR, TFR1, TR, Trfr, p90 " mRNA Mus musculus 7493976 Endoplasmic reticulum Fibroblast Northern blot Here we demonstrate that part of the active IRP co-localizes with TfR mRNA to the rough endoplasmic reticulum. RLID00006148 22042 Tfrc http://www.ncbi.nlm.nih.gov/gene/?term=22042 "2610028K12Rik, CD71, E430033M20Rik, Mtvr1, TFR, TFR1, TR, Trfr, p90 " mRNA Mus musculus 9367630 Nucleus Muscle cell In situ hybridization In situ hybridization of myotubes of the mouse muscle cell line C2 shows that TfR mRNA is concentrated in the core of the myotubes. Its distribution around the nuclei is often asymmetric and its concentration changes abruptly. RLID00006149 2204 FCAR http://www.ncbi.nlm.nih.gov/gene/?term=2204 "CD89, CTB-61M7.2, FcalphaRI " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006150 2204 FCAR http://www.ncbi.nlm.nih.gov/gene/?term=2204 "CD89, CTB-61M7.2, FcalphaRI " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006151 22051 Trip6 http://www.ncbi.nlm.nih.gov/gene/?term=22051 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006152 22067 Trpc5 http://www.ncbi.nlm.nih.gov/gene/?term=22067 "CCE2, TRP-5, TRP5, Trrp5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006153 2207 FCER1G http://www.ncbi.nlm.nih.gov/gene/?term=2207 FCRG mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006154 22083 Ctr9 http://www.ncbi.nlm.nih.gov/gene/?term=22083 "AA409336, Sh2bp1, Tsbp, Tsp, mKIAA0155 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006155 220869 CBWD5 http://www.ncbi.nlm.nih.gov/gene/?term=220869 DC36 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006156 220869 CBWD5 http://www.ncbi.nlm.nih.gov/gene/?term=220869 DC36 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006157 220963 SLC16A9 http://www.ncbi.nlm.nih.gov/gene/?term=220963 "C10orf36, MCT9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006158 220965 FAM13C http://www.ncbi.nlm.nih.gov/gene/?term=220965 FAM13C1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006159 220972 MARCH8 http://www.ncbi.nlm.nih.gov/gene/?term=220972 "CMIR, MARCH-VIII, MIR, RNF178, c-MIR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006160 22097 Tsix http://www.ncbi.nlm.nih.gov/gene/?term=22097 lncRNA Mus musculus 12900552 Nucleus Embryonic stem cell In situ hybridization|RT-PCR "On the active male X chromosome, the XIST and TSIX genes are transcribed in undifferentiated cells of pre-implantation embryos (undifferentiated state) and then down-regulated upon cell differentiation (differentiated state). " RLID00006161 220988 HNRNPA3 http://www.ncbi.nlm.nih.gov/gene/?term=220988 "2610510D13Rik, D10S102, FBRNP, HNRPA3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006162 220988 HNRNPA3 http://www.ncbi.nlm.nih.gov/gene/?term=220988 "2610510D13Rik, D10S102, FBRNP, HNRPA3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006163 22099 Tsn http://www.ncbi.nlm.nih.gov/gene/?term=22099 "2610034C24Rik, AU040286, C3PO, TB-RBP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006164 221002 RASGEF1A http://www.ncbi.nlm.nih.gov/gene/?term=221002 CG4853 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006165 221035 REEP3 http://www.ncbi.nlm.nih.gov/gene/?term=221035 "C10orf74, Yip2b " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006166 221035 REEP3 http://www.ncbi.nlm.nih.gov/gene/?term=221035 "C10orf74, Yip2b " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006167 221037 JMJD1C http://www.ncbi.nlm.nih.gov/gene/?term=221037 "TRIP-8, TRIP8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006168 221037 JMJD1C http://www.ncbi.nlm.nih.gov/gene/?term=221037 "TRIP-8, TRIP8 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006169 221079 ARL5B http://www.ncbi.nlm.nih.gov/gene/?term=221079 ARL8 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006170 221120 ALKBH3 http://www.ncbi.nlm.nih.gov/gene/?term=221120 "ABH3, DEPC-1, DEPC1, PCA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006171 221150 SKA3 http://www.ncbi.nlm.nih.gov/gene/?term=221150 "C13orf3, RAMA1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006172 22115 Tssk2 http://www.ncbi.nlm.nih.gov/gene/?term=22115 "DGS-G, SPOGA2, Stk22b, Tsk2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006173 22116 Tsks http://www.ncbi.nlm.nih.gov/gene/?term=22116 "Stk22s1, Tssks1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006174 221178 SPATA13 http://www.ncbi.nlm.nih.gov/gene/?term=221178 "ARHGEF29, ASEF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006175 22117 Tst http://www.ncbi.nlm.nih.gov/gene/?term=22117 Rhodanese mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006176 221188 ADGRG5 http://www.ncbi.nlm.nih.gov/gene/?term=221188 "GPR114, PGR27 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006177 22121 Rpl13a http://www.ncbi.nlm.nih.gov/gene/?term=22121 "1810026N22Rik, Tstap198-7, tum-antigen " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006178 221294 NT5DC1 http://www.ncbi.nlm.nih.gov/gene/?term=221294 "C6orf200, LP2642, NT5C2L1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006179 221294 NT5DC1 http://www.ncbi.nlm.nih.gov/gene/?term=221294 "C6orf200, LP2642, NT5C2L1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006180 2212 FCGR2A http://www.ncbi.nlm.nih.gov/gene/?term=2212 "CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006181 2212 FCGR2A http://www.ncbi.nlm.nih.gov/gene/?term=2212 "CD32, CD32A, CDw32, FCG2, FCGR21, FcGR, IGFR2, FCGR2A " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006182 2212 FCGR2A http://www.ncbi.nlm.nih.gov/gene/?term=2212 "CD32, CD32A, CDw32, FCG2, FCGR21, FcGR, IGFR2, FCGR2A " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006183 221302 ZUFSP http://www.ncbi.nlm.nih.gov/gene/?term=221302 "C6orf113, dJ412I7.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006184 22130 Ttf1 http://www.ncbi.nlm.nih.gov/gene/?term=22130 "AV245725, TTF-1, TTF-I " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006185 22135 Tgoln2 http://www.ncbi.nlm.nih.gov/gene/?term=22135 "TGN38B, TGN41, TGN46, Ttgn2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006186 22137 Ttk http://www.ncbi.nlm.nih.gov/gene/?term=22137 "AL022661, Esk1, Mps1, PYT, esk " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006187 221395 ADGRF5 http://www.ncbi.nlm.nih.gov/gene/?term=221395 "GPR116, KPG_001 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006188 2213 FCGR2B http://www.ncbi.nlm.nih.gov/gene/?term=2213 "CD32, CD32B, FCG2, FCGR2, IGFR2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006189 221400 TDRD6 http://www.ncbi.nlm.nih.gov/gene/?term=221400 "CT41.2, NY-CO-45, SPATA36, TDR2, bA446F17.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006190 22143 Tuba1b http://www.ncbi.nlm.nih.gov/gene/?term=22143 Tuba2 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006191 221443 OARD1 http://www.ncbi.nlm.nih.gov/gene/?term=221443 "C6orf130, TARG1, dJ34B21.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006192 22145 Tuba4a http://www.ncbi.nlm.nih.gov/gene/?term=22145 "M[a]4, Tuba4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006193 22145 Tuba4a http://www.ncbi.nlm.nih.gov/gene/?term=22145 "M[a]4, Tuba4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006194 221472 FGD2 http://www.ncbi.nlm.nih.gov/gene/?term=221472 ZFYVE4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006195 221472 FGD2 http://www.ncbi.nlm.nih.gov/gene/?term=221472 ZFYVE4 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006196 221472 FGD2 http://www.ncbi.nlm.nih.gov/gene/?term=221472 ZFYVE4 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006197 221477 C6orf89 http://www.ncbi.nlm.nih.gov/gene/?term=221477 BRAP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006198 221477 C6orf89 http://www.ncbi.nlm.nih.gov/gene/?term=221477 BRAP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006199 221491 C6orf1 http://www.ncbi.nlm.nih.gov/gene/?term=221491 LBH mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006200 221496 LEMD2 http://www.ncbi.nlm.nih.gov/gene/?term=221496 "NET25, dJ482C21.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006201 2214 FCGR3A http://www.ncbi.nlm.nih.gov/gene/?term=2214 "CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006202 221545 C6orf136 http://www.ncbi.nlm.nih.gov/gene/?term=221545 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006203 22160 Twist1 http://www.ncbi.nlm.nih.gov/gene/?term=22160 "M-Twist, Pde, Ska10, Ska, Twist, bHLHa38, pdt " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006204 221656 KDM1B http://www.ncbi.nlm.nih.gov/gene/?term=221656 "AOF1, C6orf193, LSD2, bA204B7.3, dJ298J15.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006205 221656 KDM1B http://www.ncbi.nlm.nih.gov/gene/?term=221656 "AOF1, C6orf193, LSD2, bA204B7.3, dJ298J15.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006206 221785 ZSCAN25 http://www.ncbi.nlm.nih.gov/gene/?term=221785 ZNF498 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006207 2217 FCGRT http://www.ncbi.nlm.nih.gov/gene/?term=2217 "FCRN, alpha-chain " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006208 2217 FCGRT http://www.ncbi.nlm.nih.gov/gene/?term=2217 "FCRN, alpha-chain " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006209 221830 TWISTNB http://www.ncbi.nlm.nih.gov/gene/?term=221830 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006210 221830 TWISTNB http://www.ncbi.nlm.nih.gov/gene/?term=221830 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006211 22183 Zrsr1 http://www.ncbi.nlm.nih.gov/gene/?term=22183 "D11Ncvs75, Irlgs2, SP2, U2af1-rs1, U2afbp-rs " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006212 22186 Uba52 http://www.ncbi.nlm.nih.gov/gene/?term=22186 "D8Ertd21e, Gm1863, Rps27a, Ubb, Ubc " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006213 22186 Uba52 http://www.ncbi.nlm.nih.gov/gene/?term=22186 "D8Ertd21e, Gm1863, Rps27a, Ubb, Ubc " mRNA Mus musculus 25301173 Dendrite Hippocampus In situ hybridization "Figure 2: In situ hybridization reveals species-specific patterns of localization in neuronal dendrites. Fluorescent Microscopy evaluation of biotin-conjugated oligoprobes on paraformaldehyde fixed 14-day cultured rat and mouse cortical neurons hybridized with nine biotin-conjugated oligoprobes detected with streptadivin-Alexa Fluor 568 (Invitrogen). For each probe images set, the small bottom left corner panels represent MAP2 immuno-staining. Scale bar = 20um. (A), Probes against SFRS16, ARHGDIA and HNRPK transcripts show higher dendritic localization in mouse neurons than in rat neurons (Red box). (B), Probes against ZFP410, COMMD3 and RSP6 transcripts show higher dendritic localization in rat neurons than in mouse neurons (Blue box). (C), Probes against UBA52, OLFM1 and H2AFZ transcripts show high dendritic localization in both rat and mouse neurons (Black box). Data are collected from Figure 2. " RLID00006214 22187 Ubb http://www.ncbi.nlm.nih.gov/gene/?term=22187 "AL033289, Rps27a, Uba522, Ubc, Ubb " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006215 22187 Ubb http://www.ncbi.nlm.nih.gov/gene/?term=22187 "AL033289, Rps27a, Uba522, Ubc, Ubb " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00006216 2218 FKTN http://www.ncbi.nlm.nih.gov/gene/?term=2218 "CMD1X, FCMD, LGMD2M, MDDGA4, MDDGB4, MDDGC4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006217 2218 FKTN http://www.ncbi.nlm.nih.gov/gene/?term=2218 "CMD1X, FCMD, LGMD2M, MDDGA4, MDDGB4, MDDGC4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006218 2218 FKTN http://www.ncbi.nlm.nih.gov/gene/?term=2218 "CMD1X, FCMD, LGMD2M, MDDGA4, MDDGB4, MDDGC4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006219 221908 PPP1R35 http://www.ncbi.nlm.nih.gov/gene/?term=221908 C7orf47 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006220 221908 PPP1R35 http://www.ncbi.nlm.nih.gov/gene/?term=221908 C7orf47 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006221 221927 BRAT1 http://www.ncbi.nlm.nih.gov/gene/?term=221927 "BAAT1, C7orf27, RMFSL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006222 221937 FOXK1 http://www.ncbi.nlm.nih.gov/gene/?term=221937 FOXK1L mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006223 221937 FOXK1 http://www.ncbi.nlm.nih.gov/gene/?term=221937 FOXK1L mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006224 221937 FOXK1 http://www.ncbi.nlm.nih.gov/gene/?term=221937 FOXK1L mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006225 221937 FOXK1 http://www.ncbi.nlm.nih.gov/gene/?term=221937 FOXK1L mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006226 221955 DAGLB http://www.ncbi.nlm.nih.gov/gene/?term=221955 "DAGLBETA, KCCR13L " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006227 22195 Ube2l3 http://www.ncbi.nlm.nih.gov/gene/?term=22195 "C79827, UbcM4, Ubce7 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006228 221960 CCZ1B http://www.ncbi.nlm.nih.gov/gene/?term=221960 "C7orf28B, H_NH0577018.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006229 22196 Ube2i http://www.ncbi.nlm.nih.gov/gene/?term=22196 "5830467E05Rik, F830028O17Rik, UBC9, Ubce2i, Ubce9 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006230 221981 THSD7A http://www.ncbi.nlm.nih.gov/gene/?term=221981 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006231 221 ALDH3B1 http://www.ncbi.nlm.nih.gov/gene/?term=221 "ALDH4, ALDH7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006232 22200 Uba3 http://www.ncbi.nlm.nih.gov/gene/?term=22200 "A830034N06Rik, AI256736, AI848246, AW546539, Ube1c " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006233 222068 TMED4 http://www.ncbi.nlm.nih.gov/gene/?term=222068 "ERS25, GMP25iso, HNLF, p24a3, p24alpha3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006234 222068 TMED4 http://www.ncbi.nlm.nih.gov/gene/?term=222068 "ERS25, GMP25iso, HNLF, p24a3, p24alpha3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006235 22210 Ube2b http://www.ncbi.nlm.nih.gov/gene/?term=22210 "2610301N02Rik, E2-14k, HR6B, Rad6b, mHR6B " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006236 22213 Ube2g2 http://www.ncbi.nlm.nih.gov/gene/?term=22213 "1110003O05Rik, D10Xrf369, UBC7, Ubc7p " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006237 22215 Ube3a http://www.ncbi.nlm.nih.gov/gene/?term=22215 "4732496B02, 5830462N02Rik, A130086L21Rik, Hpve6a, mKIAA4216 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006238 222166 MTURN http://www.ncbi.nlm.nih.gov/gene/?term=222166 "C7orf41, Ells1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006239 222171 PRR15 http://www.ncbi.nlm.nih.gov/gene/?term=222171 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006240 222194 RSBN1L http://www.ncbi.nlm.nih.gov/gene/?term=222194 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006241 222194 RSBN1L http://www.ncbi.nlm.nih.gov/gene/?term=222194 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006242 222194 RSBN1L http://www.ncbi.nlm.nih.gov/gene/?term=222194 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006243 222229 LRWD1 http://www.ncbi.nlm.nih.gov/gene/?term=222229 "CENP-33, ORCA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006244 22222 Ubr1 http://www.ncbi.nlm.nih.gov/gene/?term=22222 AI504731 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006245 222236 NAPEPLD http://www.ncbi.nlm.nih.gov/gene/?term=222236 "FMP30, NAPE-PLD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006246 22223 Uchl1 http://www.ncbi.nlm.nih.gov/gene/?term=22223 "AW822034, C88048, PGP 9.5, PGP9.5, R75593, UCH-L1, UCHL-1, gad " lncRNA Mus musculus 23064229 Cytoplasm MN9D cell qRT-PCR|In situ hybridizationq|Northern blot "Antisense Uchl1 function is under the control of stress signalling pathways, as mTORC1 inhibition by rapamycin causes an increase in UCHL1 protein that is associated to the shuttling of antisense Uchl1 RNA from the nucleus to the cytoplasm. " RLID00006247 22223 Uchl1 http://www.ncbi.nlm.nih.gov/gene/?term=22223 "AW822034, C88048, PGP 9.5, PGP9.5, R75593, UCH-L1, UCHL-1, gad " lncRNA Mus musculus 23064229 Nucleus MN9D cell qRT-PCR|In situ hybridizationq|Northern blot "Antisense Uchl1 function is under the control of stress signalling pathways, as mTORC1 inhibition by rapamycin causes an increase in UCHL1 protein that is associated to the shuttling of antisense Uchl1 RNA from the nucleus to the cytoplasm. " RLID00006248 222255 ATXN7L1 http://www.ncbi.nlm.nih.gov/gene/?term=222255 ATXN7L4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006249 22225 Usp5 http://www.ncbi.nlm.nih.gov/gene/?term=22225 "AA407472, ISOT, ISOT-1, Ucht " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006250 2222 FDFT1 http://www.ncbi.nlm.nih.gov/gene/?term=2222 "DGPT, ERG9, SQS, SS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006251 2222 FDFT1 http://www.ncbi.nlm.nih.gov/gene/?term=2222 "DGPT, ERG9, SQS, SS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006252 22230 Ufd1l http://www.ncbi.nlm.nih.gov/gene/?term=22230 Ufd1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006253 22234 Ugcg http://www.ncbi.nlm.nih.gov/gene/?term=22234 "AU043821, C80537, Epcs21, GlcT-1l, Ugcg " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006254 22235 Ugdh http://www.ncbi.nlm.nih.gov/gene/?term=22235 Udpgdh mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006255 22240 Dpysl3 http://www.ncbi.nlm.nih.gov/gene/?term=22240 "CRMP-4, DRP-3, TUC4, ULIP-1, Ulip, Ulip1 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006256 22240 Dpysl3 http://www.ncbi.nlm.nih.gov/gene/?term=22240 "CRMP-4, DRP-3, TUC4, ULIP-1, Ulip, Ulip1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006257 222484 LNX2 http://www.ncbi.nlm.nih.gov/gene/?term=222484 PDZRN1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006258 222484 LNX2 http://www.ncbi.nlm.nih.gov/gene/?term=222484 PDZRN1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006259 22248 Unc119 http://www.ncbi.nlm.nih.gov/gene/?term=22248 "D11Bhm52, HRG4, MRG4, Rg4, Rtg4h, Unc119 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006260 2224 FDPS http://www.ncbi.nlm.nih.gov/gene/?term=2224 "FPPS, FPS, POROK9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006261 2224 FDPS http://www.ncbi.nlm.nih.gov/gene/?term=2224 "FPPS, FPS, POROK9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006262 2224 FDPS http://www.ncbi.nlm.nih.gov/gene/?term=2224 "FPPS, FPS, POROK9 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006263 22253 Unc5c http://www.ncbi.nlm.nih.gov/gene/?term=22253 "B130051O18Rik, Unc5h3, rcm " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006264 222553 SLC35F1 http://www.ncbi.nlm.nih.gov/gene/?term=222553 "C6orf169, dJ230I3.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006265 222553 SLC35F1 http://www.ncbi.nlm.nih.gov/gene/?term=222553 "C6orf169, dJ230I3.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006266 22259 Nr1h3 http://www.ncbi.nlm.nih.gov/gene/?term=22259 "AU018371, LXR, RLD1, Unr1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006267 222643 UNC5CL http://www.ncbi.nlm.nih.gov/gene/?term=222643 "MUXA, ZUD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006268 222658 KCTD20 http://www.ncbi.nlm.nih.gov/gene/?term=222658 "C6orf69, dJ108K11.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006269 222658 KCTD20 http://www.ncbi.nlm.nih.gov/gene/?term=222658 "C6orf69, dJ108K11.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006270 22271 Upp1 http://www.ncbi.nlm.nih.gov/gene/?term=22271 "AI325217, UPase, UdRPase, Up, Upp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006271 22275 Urod http://www.ncbi.nlm.nih.gov/gene/?term=22275 "AI323803, UPD, Uro-d " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006272 22284 Usp9x http://www.ncbi.nlm.nih.gov/gene/?term=22284 "5730589N07Rik, AA407302, AA407699, AL022658, AL022749, Dffrx, FAF-X, Fafl " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006273 222865 TMEM130 http://www.ncbi.nlm.nih.gov/gene/?term=222865 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006274 22288 Utrn http://www.ncbi.nlm.nih.gov/gene/?term=22288 "AA589569, DRP, Dmdl " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006275 222962 SLC29A4 http://www.ncbi.nlm.nih.gov/gene/?term=222962 "ENT4, PMAT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006276 22297 Vmn1r45 http://www.ncbi.nlm.nih.gov/gene/?term=22297 "V1RA9, V1r2, V1ra11, V1ra2, mV1R2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006277 223082 ZNRF2 http://www.ncbi.nlm.nih.gov/gene/?term=223082 RNF202 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006278 2230 FDX1 http://www.ncbi.nlm.nih.gov/gene/?term=2230 "ADX, FDX, LOH11CR1D " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006279 2230 FDX1 http://www.ncbi.nlm.nih.gov/gene/?term=2230 "ADX, FDX, LOH11CR1D " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006280 22310 Vmn2r42 http://www.ncbi.nlm.nih.gov/gene/?term=22310 V2r4 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006281 223117 SEMA3D http://www.ncbi.nlm.nih.gov/gene/?term=223117 "Sema-Z2, coll-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006282 223117 SEMA3D http://www.ncbi.nlm.nih.gov/gene/?term=223117 "Sema-Z2, coll-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006283 22311 Vmn2r32 http://www.ncbi.nlm.nih.gov/gene/?term=22311 V2r5 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006284 22317 Vamp1 http://www.ncbi.nlm.nih.gov/gene/?term=22317 "Syb-1, Syb1, VAMP-1, lew " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006285 22318 Vamp2 http://www.ncbi.nlm.nih.gov/gene/?term=22318 "Syb-2, Syb2, sybII " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006286 22320 Vamp8 http://www.ncbi.nlm.nih.gov/gene/?term=22320 "AU041171, Edb, endobrevin " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006287 2232 FDXR http://www.ncbi.nlm.nih.gov/gene/?term=2232 ADXR mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006288 22330 Vcl http://www.ncbi.nlm.nih.gov/gene/?term=22330 "9430097D22, AA571387, AI462105, AW545629 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006289 223337 Ugt3a2 http://www.ncbi.nlm.nih.gov/gene/?term=223337 AI313915 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006290 22339 Vegfa http://www.ncbi.nlm.nih.gov/gene/?term=22339 "Vegf, Vpf " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006291 22341 Vegfc http://www.ncbi.nlm.nih.gov/gene/?term=22341 "AW228853, VEGF-C " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006292 22344 Vezf1 http://www.ncbi.nlm.nih.gov/gene/?term=22344 "AI848691, AW046909, db1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006293 223455 March6 http://www.ncbi.nlm.nih.gov/gene/?term=223455 "3830408G03, F830029L24Rik, mKIAA0597 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006294 223499 Dcaf13 http://www.ncbi.nlm.nih.gov/gene/?term=223499 "Gm83, Wdsof1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006295 223499 Dcaf13 http://www.ncbi.nlm.nih.gov/gene/?term=223499 "Gm83, Wdsof1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006296 22349 Vil1 http://www.ncbi.nlm.nih.gov/gene/?term=22349 Vil mRNA Mus musculus 8026647 Apical Enterocytes In situ hybridization "In adult tissues, however, each mRNA species was associated with a specific compartment (Fig. 6B). In the apical cytoplasm, mRNAs coding for brush-border NEP were concentrated closer to the nucleus than those encoding for villin, which were localized in a more apical region of the cytoplasm. " RLID00006297 223593 E430025E21Rik http://www.ncbi.nlm.nih.gov/gene/?term=223593 "AL022848, C76463, Kiaa0196, mKIAA0196, strumpellin " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006298 2235 FECH http://www.ncbi.nlm.nih.gov/gene/?term=2235 "EPP, FCE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006299 2235 FECH http://www.ncbi.nlm.nih.gov/gene/?term=2235 "EPP, FCE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006300 2235 FECH http://www.ncbi.nlm.nih.gov/gene/?term=2235 "EPP, FCE " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006301 2235 FECH http://www.ncbi.nlm.nih.gov/gene/?term=2235 "EPP, FCE " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006302 223601 Fam49b http://www.ncbi.nlm.nih.gov/gene/?term=223601 "0910001A06Rik, AW122079 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006303 22360 Nrsn1 http://www.ncbi.nlm.nih.gov/gene/?term=22360 "Neurensin-1, Neuro-p24, Vmp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006304 223626 Them6 http://www.ncbi.nlm.nih.gov/gene/?term=223626 4930572J05Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006305 223646 Naprt http://www.ncbi.nlm.nih.gov/gene/?term=223646 "9130210N20Rik1, Naprt " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006306 223664 Lrrc14 http://www.ncbi.nlm.nih.gov/gene/?term=223664 "E130306I01Rik, mKIAA0014 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006307 223690 Ankrd54 http://www.ncbi.nlm.nih.gov/gene/?term=223690 "C730048E16Rik, EST1068184, EST475269, Liar " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006308 223723 Ttll12 http://www.ncbi.nlm.nih.gov/gene/?term=223723 "BC055368, D430005B17 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006309 223739 5031439G07Rik http://www.ncbi.nlm.nih.gov/gene/?term=223739 "AW554572, mKIAA0930 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006310 223752 Gramd4 http://www.ncbi.nlm.nih.gov/gene/?term=223752 9930016O13 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006311 22375 Wars http://www.ncbi.nlm.nih.gov/gene/?term=22375 "TrpRS, WRS " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006312 223775 Pim3 http://www.ncbi.nlm.nih.gov/gene/?term=223775 "BC026639, Kid1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006313 22378 Wbp2 http://www.ncbi.nlm.nih.gov/gene/?term=22378 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006314 2237 FEN1 http://www.ncbi.nlm.nih.gov/gene/?term=2237 "FEN-1, MF1, RAD2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006315 2237 FEN1 http://www.ncbi.nlm.nih.gov/gene/?term=2237 "FEN-1, MF1, RAD2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006316 22380 Wbp4 http://www.ncbi.nlm.nih.gov/gene/?term=22380 "AW545037, BB101031, FBP21 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006317 22385 Baz1b http://www.ncbi.nlm.nih.gov/gene/?term=22385 "C87820, WSTF, Wbscr9 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006318 223864 Rapgef3 http://www.ncbi.nlm.nih.gov/gene/?term=223864 "2310016P22Rik, 9330170P05Rik, Epac, Epac1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006319 223869 A130012F09 http://www.ncbi.nlm.nih.gov/gene/?term=223869 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006320 223870 Senp1 http://www.ncbi.nlm.nih.gov/gene/?term=223870 "2310046A20Rik, D15Ertd528e, E330036L07Rik, suPr-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006321 223922 Atf7 http://www.ncbi.nlm.nih.gov/gene/?term=223922 "1110012F10Rik, 9430065F09Rik, AI549878, C130020M04Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006322 2239 GPC4 http://www.ncbi.nlm.nih.gov/gene/?term=2239 K-glypican mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006323 223 ALDH9A1 http://www.ncbi.nlm.nih.gov/gene/?term=223 "ALDH4, ALDH7, ALDH9, E3, TMABADH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006324 223 ALDH9A1 http://www.ncbi.nlm.nih.gov/gene/?term=223 "ALDH4, ALDH7, ALDH9, E3, TMABADH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006325 223 ALDH9A1 http://www.ncbi.nlm.nih.gov/gene/?term=223 "ALDH4, ALDH7, ALDH9, E3, TMABADH " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006326 224014 Fgd4 http://www.ncbi.nlm.nih.gov/gene/?term=224014 "9030023J02Rik, 9330209B17Rik, Frabp, ZFYVE6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006327 224019 Tmem191c http://www.ncbi.nlm.nih.gov/gene/?term=224019 "4933405M22Rik, D16Bwg1494e, MNCb-4137 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006328 22401 Zmat3 http://www.ncbi.nlm.nih.gov/gene/?term=22401 Wig1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006329 22402 Wisp1 http://www.ncbi.nlm.nih.gov/gene/?term=22402 "AW146261, CCN4, Elm1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006330 224044 Cyp2ab1 http://www.ncbi.nlm.nih.gov/gene/?term=224044 "EG224044, F730023N20 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006331 22404 Wiz http://www.ncbi.nlm.nih.gov/gene/?term=22404 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006332 224088 Atp13a3 http://www.ncbi.nlm.nih.gov/gene/?term=224088 "AU022875, Gm1745, Gm541, Gm542 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006333 224092 Lsg1 http://www.ncbi.nlm.nih.gov/gene/?term=224092 "5830465I20, AA409273, D16Bwg1547e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006334 224111 Ubxn7 http://www.ncbi.nlm.nih.gov/gene/?term=224111 "A630090P18, AI196514, Ubxd7, mKIAA0794 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006335 224116 Muc20 http://www.ncbi.nlm.nih.gov/gene/?term=224116 BC026367 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006336 22411 Wnt11 http://www.ncbi.nlm.nih.gov/gene/?term=22411 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006337 224139 Golgb1 http://www.ncbi.nlm.nih.gov/gene/?term=224139 "4930428L02Rik, 628101, 6330407A06Rik, AU042952, C130074L01Rik, F730017E11Rik, Gm6840, mKIAA4151 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006338 224143 Poglut1 http://www.ncbi.nlm.nih.gov/gene/?term=224143 "9630046K23Rik, Clp46, Ktelc1, Rumi " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006339 22415 Wnt3 http://www.ncbi.nlm.nih.gov/gene/?term=22415 "Int-4, Wnt-3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006340 224170 Dzip3 http://www.ncbi.nlm.nih.gov/gene/?term=224170 "2310047C04Rik, 2A-HUB, 6430549P11Rik, A230104G20 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006341 224250 Cldnd1 http://www.ncbi.nlm.nih.gov/gene/?term=224250 "1110019C08Rik, AA407103, AI849195, AW489850, Cldn25 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006342 22427 Wrn http://www.ncbi.nlm.nih.gov/gene/?term=22427 AI846146 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006343 22428 Dctn6 http://www.ncbi.nlm.nih.gov/gene/?term=22428 "AU044699, WS-3, p27 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006344 22431 Wt1 http://www.ncbi.nlm.nih.gov/gene/?term=22431 "D630046I19Rik, Wt-1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006345 22431 Wt1 http://www.ncbi.nlm.nih.gov/gene/?term=22431 "D630046I19Rik, Wt-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006346 22433 Xbp1 http://www.ncbi.nlm.nih.gov/gene/?term=22433 "D11Ertd39e, TREB-5, TREB5, XBP-1 " mRNA Mus musculus 26068456 Nucleus MCF-7|293T|T47D |3T3 cell RT-PCR "Our results reveal the presence of basal unconventional splicing of XBP1 mRNA in the nucleus that also requires inositol-requiring transmembrane kinase and endonuclease 1a (IRE1a) and can occur independently of acute ER stress. Furthermore, we confirm that acute ER stress induces the splicing of XBP1 mRNA predominantly occurring in the cytoplasm, but it also promotes the splicing in the nucleus. " RLID00006347 22433 Xbp1 http://www.ncbi.nlm.nih.gov/gene/?term=22433 "D11Ertd39e, TREB-5, TREB5, XBP-1 " mRNA Mus musculus 26068456 Cytoplasm MCF-7|293T|T47D |3T3 cell RT-PCR "Our results reveal the presence of basal unconventional splicing of XBP1 mRNA in the nucleus that also requires inositol-requiring transmembrane kinase and endonuclease 1a (IRE1a) and can occur independently of acute ER stress. Furthermore, we confirm that acute ER stress induces the splicing of XBP1 mRNA predominantly occurring in the cytoplasm, but it also promotes the splicing in the nucleus. " RLID00006348 22437 Xirp1 http://www.ncbi.nlm.nih.gov/gene/?term=22437 "AI415219, Cmya1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006349 2243 FGA http://www.ncbi.nlm.nih.gov/gene/?term=2243 Fib2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006350 2244 FGB http://www.ncbi.nlm.nih.gov/gene/?term=2244 HEL-S-78p mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006351 224613 Flywch1 http://www.ncbi.nlm.nih.gov/gene/?term=224613 "E030034P13Rik, mKIAA1552 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006352 224647 D17Wsu92e http://www.ncbi.nlm.nih.gov/gene/?term=224647 "AU020189, C030010A15, C80239 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006353 224694 Zfp81 http://www.ncbi.nlm.nih.gov/gene/?term=224694 "AA409460, AA409461, C330034P10Rik, D330034E10Rik, Hszfp36, KRAB13, Zfp78 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006354 2246 FGF1 http://www.ncbi.nlm.nih.gov/gene/?term=2246 "AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006355 224703 March2 http://www.ncbi.nlm.nih.gov/gene/?term=224703 "9530046H09Rik, MARCH-II " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006356 224742 Abcf1 http://www.ncbi.nlm.nih.gov/gene/?term=224742 "AU041969, Abc50, D17Wsu166e, GCN20 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006357 224794 Enpp4 http://www.ncbi.nlm.nih.gov/gene/?term=224794 "4933413N07Rik, AA986363, AI195364, E-NPP 4, Gm90, mKIAA0879 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006358 2247 FGF2 http://www.ncbi.nlm.nih.gov/gene/?term=2247 "BFGF, FGF-2, FGFB, HBGF-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006359 2247 FGF2 http://www.ncbi.nlm.nih.gov/gene/?term=2247 "BFGF, FGF-2, FGFB, HBGF-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006360 224813 Lrrc73 http://www.ncbi.nlm.nih.gov/gene/?term=224813 Gm88 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006361 224824 Pex6 http://www.ncbi.nlm.nih.gov/gene/?term=224824 "AI132582, D130055I09Rik, mKIAA4177 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006362 224826 Ubr2 http://www.ncbi.nlm.nih.gov/gene/?term=224826 "9930021A08Rik, AI462103, AW540746, E130209G04Rik, mKIAA0349 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006363 224826 Ubr2 http://www.ncbi.nlm.nih.gov/gene/?term=224826 "9930021A08Rik, AI462103, AW540746, E130209G04Rik, mKIAA0349 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006364 224860 Plcl2 http://www.ncbi.nlm.nih.gov/gene/?term=224860 "PLC-L2, PRIP-2, Plce2, mKIAA1092 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006365 224902 Safb2 http://www.ncbi.nlm.nih.gov/gene/?term=224902 "AA389433, AI255170, mKIAA0138 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006366 224903 Safb http://www.ncbi.nlm.nih.gov/gene/?term=224903 "3110021E02Rik, 5330423C17Rik, AU018122, D18386, E130307D12, HAP, HET, SAF-B1, SAFB1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006367 224938 Pja2 http://www.ncbi.nlm.nih.gov/gene/?term=224938 "AI447901, AL022700, Neurodap1, mKIAA0438 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006368 224 ALDH3A2 http://www.ncbi.nlm.nih.gov/gene/?term=224 "ALDH10, FALDH, SLS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006369 224 ALDH3A2 http://www.ncbi.nlm.nih.gov/gene/?term=224 "ALDH10, FALDH, SLS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006370 225028 Map4k3 http://www.ncbi.nlm.nih.gov/gene/?term=225028 "4833416M01Rik, 4833416M07Rik, 9530052P13Rik, Glk, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006371 2250 FGF5 http://www.ncbi.nlm.nih.gov/gene/?term=2250 "HBGF-5, Smag-82, TCMGLY " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006372 2250 FGF5 http://www.ncbi.nlm.nih.gov/gene/?term=2250 "HBGF-5, Smag-82, TCMGLY " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006373 225131 Wac http://www.ncbi.nlm.nih.gov/gene/?term=225131 "1110067P07Rik, A230035H12Rik, AI256735, AI256776, Wwp4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006374 225164 Mib1 http://www.ncbi.nlm.nih.gov/gene/?term=225164 "DIP-1, E430019M12Rik, Mib, mKIAA1323 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006375 225182 Rbbp8 http://www.ncbi.nlm.nih.gov/gene/?term=225182 "9930104E21Rik, CtIP, RBBP-8, RIM, SAE2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006376 225207 Zfp521 http://www.ncbi.nlm.nih.gov/gene/?term=225207 "B930086A16Rik, Evi3, Znf521 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006377 225228 Gm4835 http://www.ncbi.nlm.nih.gov/gene/?term=225228 EG225228 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006378 225283 Rprd1a http://www.ncbi.nlm.nih.gov/gene/?term=225283 "C77387, mKIAA4077 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006379 225339 Ammecr1l http://www.ncbi.nlm.nih.gov/gene/?term=225339 "5430429D03Rik, AU022236, AU040755, AW111353, E230022H04Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006380 225339 Ammecr1l http://www.ncbi.nlm.nih.gov/gene/?term=225339 "5430429D03Rik, AU022236, AU040755, AW111353, E230022H04Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006381 225341 Lims2 http://www.ncbi.nlm.nih.gov/gene/?term=225341 PINCH2 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006382 225348 Wdr36 http://www.ncbi.nlm.nih.gov/gene/?term=225348 "5730444A13Rik, Ta-wdrp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006383 225363 Etf1 http://www.ncbi.nlm.nih.gov/gene/?term=225363 "AI463371, D6Ertd109e, ERF, ERF1, SUP45L1, TB3-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006384 225432 Rbm27 http://www.ncbi.nlm.nih.gov/gene/?term=225432 "A730010I06, AI043120, Psc1, mKIAA1311 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006385 225467 Pggt1b http://www.ncbi.nlm.nih.gov/gene/?term=225467 "2010207C17Rik, 2610100E13, AI451237, AI551093, BGG1, GGT1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006386 225471 Ticam2 http://www.ncbi.nlm.nih.gov/gene/?term=225471 "B430113A10, TICAM-2, TRAM, Tirp, Trif " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006387 225497 Fam170a http://www.ncbi.nlm.nih.gov/gene/?term=225497 "Gm93, Znfd " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006388 225523 Cep120 http://www.ncbi.nlm.nih.gov/gene/?term=225523 "A230075C01, AU016693, Ccdc100 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006389 225608 Sh3tc2 http://www.ncbi.nlm.nih.gov/gene/?term=225608 D430044G18Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006390 225631 Onecut2 http://www.ncbi.nlm.nih.gov/gene/?term=225631 "C730009D12, OC-2, Oc2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006391 225638 Alpk2 http://www.ncbi.nlm.nih.gov/gene/?term=225638 "Gm549, Hak " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006392 225745 Haus1 http://www.ncbi.nlm.nih.gov/gene/?term=225745 "BC024400, Ccdc5, HEI-C " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006393 225791 Zadh2 http://www.ncbi.nlm.nih.gov/gene/?term=225791 "C530046K17Rik, Pthr3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006394 2257 FGF12 http://www.ncbi.nlm.nih.gov/gene/?term=2257 "FGF12B, FHF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006395 225849 Ppp2r5b http://www.ncbi.nlm.nih.gov/gene/?term=225849 "B'beta, BC026670 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006396 225870 Rin1 http://www.ncbi.nlm.nih.gov/gene/?term=225870 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006397 225876 Kdm2a http://www.ncbi.nlm.nih.gov/gene/?term=225876 "100043628, 5530401A10Rik, AA589516, AW536790, Cxxc8, Fbl11, Fbl7, Fbxl11, Gm4560, Jhdm1, Jhdm1a, lalina " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006398 225887 Ndufs8 http://www.ncbi.nlm.nih.gov/gene/?term=225887 "BC021616, CI-23kD, TYKY " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006399 225895 Taf6l http://www.ncbi.nlm.nih.gov/gene/?term=225895 "2810417N14Rik, BB223262, C530024J06Rik, Paf65a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006400 22589 Atrx http://www.ncbi.nlm.nih.gov/gene/?term=22589 "4833408C14Rik, AI447451, ATR2, DXHXS6677E, HP1-BP38, Hp1bp2, Hp1bp38, MRXS3, RAD54L, Rad54, XH2, Xnp, ZNF-HX " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006401 22590 Xpa http://www.ncbi.nlm.nih.gov/gene/?term=22590 "AI573865c, Xpa " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006402 22592 Ercc5 http://www.ncbi.nlm.nih.gov/gene/?term=22592 Xpg mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006403 22594 Xrcc1 http://www.ncbi.nlm.nih.gov/gene/?term=22594 Xrcc-1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006404 2259 FGF14 http://www.ncbi.nlm.nih.gov/gene/?term=2259 "FGF-14, FHF-4, FHF4, SCA27 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006405 226049 Dmrt2 http://www.ncbi.nlm.nih.gov/gene/?term=226049 Terra mRNA Mus musculus 17916692 Nucleus Renal cancer cell In situ hybridization|Northern blot "TERRA molecules are heterogeneous in length, are transcribed from several subtelomeric loci toward chromosome ends, and localize to telomeres. " RLID00006406 226049 Dmrt2 http://www.ncbi.nlm.nih.gov/gene/?term=226049 Terra lncRNA Mus musculus 25332394 Nucleus - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/terra/ RLID00006407 226089 Ric1 http://www.ncbi.nlm.nih.gov/gene/?term=226089 "C030046E11Rik, C130057E09Rik, Kiaa1432 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006408 2260 FGFR1 http://www.ncbi.nlm.nih.gov/gene/?term=2260 "BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006409 226122 Ubtd1 http://www.ncbi.nlm.nih.gov/gene/?term=226122 BC016129 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006410 22612 Yes1 http://www.ncbi.nlm.nih.gov/gene/?term=22612 "Yes, p61-Yes " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006411 226144 Erlin1 http://www.ncbi.nlm.nih.gov/gene/?term=226144 "2810439N09Rik, C80197, Keo4, Spfh1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006412 226151 Fam178a http://www.ncbi.nlm.nih.gov/gene/?term=226151 "3632432H19, 6030443O07Rik, AU014917, Slf2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006413 226162 Dpcd http://www.ncbi.nlm.nih.gov/gene/?term=226162 "5330431N19Rik, Ndac " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006414 2261 FGFR3 http://www.ncbi.nlm.nih.gov/gene/?term=2261 "ACH, CD333, CEK2, HSFGFR3EX, JTK4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006415 226252 Fam160b1 http://www.ncbi.nlm.nih.gov/gene/?term=226252 "AI450540, mKIAA1600 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006416 226255 Atrnl1 http://www.ncbi.nlm.nih.gov/gene/?term=226255 "AI504415, AW555641, Alp, Atrnl, Atrnlp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006417 22630 Ywhaq http://www.ncbi.nlm.nih.gov/gene/?term=22630 "2700028P07Rik, AA409740, AU021156, R74690 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006418 22631 Ywhaz http://www.ncbi.nlm.nih.gov/gene/?term=22631 "1110013I11Rik, 14-3-3zeta, AI596267, AL022924, AU020854 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006419 22632 Yy1 http://www.ncbi.nlm.nih.gov/gene/?term=22632 "AW488674, NF-E1 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006420 22632 Yy1 http://www.ncbi.nlm.nih.gov/gene/?term=22632 "AW488674, NF-E1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006421 22632 Yy1 http://www.ncbi.nlm.nih.gov/gene/?term=22632 "AW488674, NF-E1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006422 226351 Tmem185b http://www.ncbi.nlm.nih.gov/gene/?term=226351 2500001K11Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006423 226352 Epb41l5 http://www.ncbi.nlm.nih.gov/gene/?term=226352 "1700030C16Rik, AL022914, BE37, E230025E14Rik, Epb4.1l5, Lulu1, NBL5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006424 2263 FGFR2 http://www.ncbi.nlm.nih.gov/gene/?term=2263 "BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006425 2263 FGFR2 http://www.ncbi.nlm.nih.gov/gene/?term=2263 "BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006426 226412 R3hdm1 http://www.ncbi.nlm.nih.gov/gene/?term=226412 R3hdm mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006427 226414 Dars http://www.ncbi.nlm.nih.gov/gene/?term=226414 5730439G15Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006428 226422 Rab29 http://www.ncbi.nlm.nih.gov/gene/?term=226422 Rab7l1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006429 226442 Zfp281 http://www.ncbi.nlm.nih.gov/gene/?term=226442 Znf281 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006430 226442 Zfp281 http://www.ncbi.nlm.nih.gov/gene/?term=226442 Znf281 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006431 22644 Rnf103 http://www.ncbi.nlm.nih.gov/gene/?term=22644 "AW146237, AW212918, Zfp103, kf-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006432 22646 Zfp105 http://www.ncbi.nlm.nih.gov/gene/?term=22646 AW557864 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006433 2264 FGFR4 http://www.ncbi.nlm.nih.gov/gene/?term=2264 "CD334, JTK2, TKF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006434 226517 Smg7 http://www.ncbi.nlm.nih.gov/gene/?term=226517 "9430023P16Rik, mKIAA0250 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006435 226519 Lamc1 http://www.ncbi.nlm.nih.gov/gene/?term=226519 Lamb2 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006436 22651 Zfp125 http://www.ncbi.nlm.nih.gov/gene/?term=22651 ZT2 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006437 226548 Aph1a http://www.ncbi.nlm.nih.gov/gene/?term=226548 "6530402N02Rik, APH-1a " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006438 22654 Zfp13 http://www.ncbi.nlm.nih.gov/gene/?term=22654 "4933429B21, AI835008, Krox-8, Rhit, Zfp-13 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006439 226562 Prrc2c http://www.ncbi.nlm.nih.gov/gene/?term=226562 "1810043M20Rik, 9630039I18Rik, A630006J20, Bat2d, Bat2d1, Bat2l2, E130112L15Rik, Prrc3, mKIAA1096 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006440 226562 Prrc2c http://www.ncbi.nlm.nih.gov/gene/?term=226562 "1810043M20Rik, 9630039I18Rik, A630006J20, Bat2d, Bat2d1, Bat2l2, E130112L15Rik, Prrc3, mKIAA1096 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006441 22658 Pcgf2 http://www.ncbi.nlm.nih.gov/gene/?term=22658 "Mel18, Rnf110, Zfp144, mel-18 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006442 226591 Tiprl http://www.ncbi.nlm.nih.gov/gene/?term=226591 1810011K17Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006443 226610 Fam78b http://www.ncbi.nlm.nih.gov/gene/?term=226610 "C030014K22Rik, C030020L09Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006444 22661 Zfp148 http://www.ncbi.nlm.nih.gov/gene/?term=22661 "2210405J08Rik, AI480666, AW045217, BERF-1, BFCOL1, ZBP-89, Znf148 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006445 226641 Atf6 http://www.ncbi.nlm.nih.gov/gene/?term=226641 "9130025P16Rik, 9630036G24, AA789574alpha, ESTM49, Atf6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006446 226641 Atf6 http://www.ncbi.nlm.nih.gov/gene/?term=226641 "9130025P16Rik, 9630036G24, AA789574alpha, ESTM49, Atf6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006447 226654 Tstd1 http://www.ncbi.nlm.nih.gov/gene/?term=226654 "AV065366, EG226654, Gm4848, KAT " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006448 22668 Sf1 http://www.ncbi.nlm.nih.gov/gene/?term=22668 "BBP, MZFM, WBP4, Zfp162 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006449 22668 Sf1 http://www.ncbi.nlm.nih.gov/gene/?term=22668 "BBP, MZFM, WBP4, Zfp162 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006450 226691 AI607873 http://www.ncbi.nlm.nih.gov/gene/?term=226691 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006451 226744 Cnst http://www.ncbi.nlm.nih.gov/gene/?term=226744 9630058J23Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006452 226747 Ahctf1 http://www.ncbi.nlm.nih.gov/gene/?term=226747 "6230412P20Rik, AV011447, Elys " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006453 226751 Cdc42bpa http://www.ncbi.nlm.nih.gov/gene/?term=226751 "A930014J19Rik, DMPK-like " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006454 226757 Wdr26 http://www.ncbi.nlm.nih.gov/gene/?term=226757 "1600024A01Rik, AA693241, AI447817, AU044014, C77982, Gid7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006455 22680 Zfp207 http://www.ncbi.nlm.nih.gov/gene/?term=22680 "8430401D15Rik, BuGZ, Zep, Znf207 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006456 22682 Zfand5 http://www.ncbi.nlm.nih.gov/gene/?term=22682 "2310057A04Rik, 5830475F03Rik, AA415485, Za20d2, Zfp216 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006457 226844 Mfsd7b http://www.ncbi.nlm.nih.gov/gene/?term=226844 "9630055N22Rik, FLVCR, Flvcr1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006458 226849 Ppp2r5a http://www.ncbi.nlm.nih.gov/gene/?term=226849 PR61alpha mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006459 226849 Ppp2r5a http://www.ncbi.nlm.nih.gov/gene/?term=226849 PR61alpha mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006460 226856 Lpgat1 http://www.ncbi.nlm.nih.gov/gene/?term=226856 "AI649174, AW112037, BC013667 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006461 22688 Zfp26 http://www.ncbi.nlm.nih.gov/gene/?term=22688 "5033428C05Rik, KRAB15, Zfp-26, Zfp70, Zfp81-rs1, mKIAA4196, mkr-3, mszf14, mszf52 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006462 22690 Zfp28 http://www.ncbi.nlm.nih.gov/gene/?term=22690 "2810438M17Rik, Zfp-28, mkr-5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006463 22695 Zfp36 http://www.ncbi.nlm.nih.gov/gene/?term=22695 "Gos24, Nup475, TIS11D, TISII, Tis11, Ttp, Zfp-36 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006464 226976 Kansl3 http://www.ncbi.nlm.nih.gov/gene/?term=226976 "4632411B12Rik, 4932435K23, AI431067, AI647574, C85723, Kiaa1310, mKIAA1310 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006465 226 ALDOA http://www.ncbi.nlm.nih.gov/gene/?term=226 "ALDA, GSD12, HEL-S-87p " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006466 226 ALDOA http://www.ncbi.nlm.nih.gov/gene/?term=226 "ALDA, GSD12, HEL-S-87p " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006467 226 ALDOA http://www.ncbi.nlm.nih.gov/gene/?term=226 "ALDA, GSD12, HEL-S-87p " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006468 227095 Hibch http://www.ncbi.nlm.nih.gov/gene/?term=227095 "2610509I15Rik, HIBYL-COA-H " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006469 22709 Zfp51 http://www.ncbi.nlm.nih.gov/gene/?term=22709 "Zfp-51, zfec12 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006470 22712 Zfp54 http://www.ncbi.nlm.nih.gov/gene/?term=22712 "2810034D10Rik, KRAB10, Zfp-54, Zfp76, mszf83 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006471 22717 Zfp59 http://www.ncbi.nlm.nih.gov/gene/?term=22717 "Mfg-2, Mfg2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006472 22718 Zfp60 http://www.ncbi.nlm.nih.gov/gene/?term=22718 "6330516O17Rik, AI426106, AI449354, Mfg-3, Mfg3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006473 227197 Ndufs1 http://www.ncbi.nlm.nih.gov/gene/?term=227197 "5830412M15Rik, 9930026A05Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006474 22719 Zfp61 http://www.ncbi.nlm.nih.gov/gene/?term=22719 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006475 2271 FH http://www.ncbi.nlm.nih.gov/gene/?term=2271 "FMRD, HLRCC, LRCC, MCL, MCUL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006476 2271 FH http://www.ncbi.nlm.nih.gov/gene/?term=2271 "FMRD, HLRCC, LRCC, MCL, MCUL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006477 2271 FH http://www.ncbi.nlm.nih.gov/gene/?term=2271 "FMRD, HLRCC, LRCC, MCL, MCUL1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006478 227210 Ccnyl1 http://www.ncbi.nlm.nih.gov/gene/?term=227210 "9630037P07Rik, AW554339 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006479 22722 Zfp64 http://www.ncbi.nlm.nih.gov/gene/?term=22722 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006480 22724 Zbtb7b http://www.ncbi.nlm.nih.gov/gene/?term=22724 "Thpok, Zfp67, c-Krox " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006481 227292 Ctdsp1 http://www.ncbi.nlm.nih.gov/gene/?term=227292 "GIP, NLIIF, Nif3, SCP1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006482 2272 FHIT http://www.ncbi.nlm.nih.gov/gene/?term=2272 "AP3Aase, FRA3B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006483 227331 Gigyf2 http://www.ncbi.nlm.nih.gov/gene/?term=227331 "2610016F01Rik, A830080H02Rik, AI852361, AW259676, BC006835, Tnrc15, mKIAA0642 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006484 227334 Usp40 http://www.ncbi.nlm.nih.gov/gene/?term=227334 "B230215L03Rik, C730029K03 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006485 227399 Ppip5k2 http://www.ncbi.nlm.nih.gov/gene/?term=227399 "AW555814, Cfap160, D330021B20, Hisppd1, Vip2, mKIAA0433 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006486 227446 2310035C23Rik http://www.ncbi.nlm.nih.gov/gene/?term=227446 "6430401N10, Kiaa1468, mKIAA1468 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006487 227449 Zcchc2 http://www.ncbi.nlm.nih.gov/gene/?term=227449 "9930114B20Rik, AW212015 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006488 2274 FHL2 http://www.ncbi.nlm.nih.gov/gene/?term=2274 "AAG11, DRAL, FHL-2, SLIM-3, SLIM3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006489 2274 FHL2 http://www.ncbi.nlm.nih.gov/gene/?term=2274 "AAG11, DRAL, FHL-2, SLIM-3, SLIM3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006490 2274 FHL2 http://www.ncbi.nlm.nih.gov/gene/?term=2274 "AAG11, DRAL, FHL-2, SLIM-3, SLIM3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006491 22758 Zscan12 http://www.ncbi.nlm.nih.gov/gene/?term=22758 "2510038J07Rik, FPM315, Zfp96, mKIAA0426, zfp-96 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006492 22759 Zfp97 http://www.ncbi.nlm.nih.gov/gene/?term=22759 NGD16-4 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006493 2275 FHL3 http://www.ncbi.nlm.nih.gov/gene/?term=2275 SLIM2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006494 227619 Man1b1 http://www.ncbi.nlm.nih.gov/gene/?term=227619 "E430019H13Rik, ERMan1, Gm108, MANA-ER " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006495 227622 BC029214 http://www.ncbi.nlm.nih.gov/gene/?term=227622 "D930050G13Rik, Paxx " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006496 22763 Zfr http://www.ncbi.nlm.nih.gov/gene/?term=22763 C920030H05Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006497 227644 Snapc4 http://www.ncbi.nlm.nih.gov/gene/?term=227644 5730436L13Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006498 22764 Zfx http://www.ncbi.nlm.nih.gov/gene/?term=22764 "Zfx55, 6, Zfx6, Zfx " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006499 227700 Sh3glb2 http://www.ncbi.nlm.nih.gov/gene/?term=227700 SPAS-1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006500 22771 Zic1 http://www.ncbi.nlm.nih.gov/gene/?term=22771 "ZIC, ZNF201 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006501 227721 Plpp7 http://www.ncbi.nlm.nih.gov/gene/?term=227721 "D830019K17Rik, NET39, Ppapdc3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006502 227723 Prrc2b http://www.ncbi.nlm.nih.gov/gene/?term=227723 "5830434P21Rik, AI173903, Bat2l, Bat2l1, D430039P21, mKIAA0515 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006503 22772 Zic2 http://www.ncbi.nlm.nih.gov/gene/?term=22772 "HPE5, Ku " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006504 227731 Slc25a25 http://www.ncbi.nlm.nih.gov/gene/?term=227731 "1110030N17Rik, MCSC, mKIAA1896 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006505 227737 Fam129b http://www.ncbi.nlm.nih.gov/gene/?term=227737 9130404D14Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006506 227746 Rabepk http://www.ncbi.nlm.nih.gov/gene/?term=227746 "8430412M01Rik, 9530020D24Rik, AV073337, C87311, Rab9p40 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006507 227746 Rabepk http://www.ncbi.nlm.nih.gov/gene/?term=227746 "8430412M01Rik, 9530020D24Rik, AV073337, C87311, Rab9p40 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006508 227753 Gsn http://www.ncbi.nlm.nih.gov/gene/?term=227753 ADF mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006509 227800 Rabgap1 http://www.ncbi.nlm.nih.gov/gene/?term=227800 "Gapcena, mKIAA4104 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006510 22782 Slc30a1 http://www.ncbi.nlm.nih.gov/gene/?term=22782 "AI839647, C130040I11Rik, Znt1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006511 227835 Gtdc1 http://www.ncbi.nlm.nih.gov/gene/?term=227835 E330008O22Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006512 22785 Slc30a4 http://www.ncbi.nlm.nih.gov/gene/?term=22785 "Znt4, lm, znT-4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006513 22785 Slc30a4 http://www.ncbi.nlm.nih.gov/gene/?term=22785 "Znt4, lm, znT-4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006514 227929 Cytip http://www.ncbi.nlm.nih.gov/gene/?term=227929 "A130053M09Rik, AI462064, C80816, Cbp, Cybr, Pscdbp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006515 227937 Pkp4 http://www.ncbi.nlm.nih.gov/gene/?term=227937 "5031422I09Rik, 9430019K17Rik, Armrp, p0071 " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00006516 22793 Zyx http://www.ncbi.nlm.nih.gov/gene/?term=22793 "9530098H06Rik, R75157 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006517 22794 CASC3 http://www.ncbi.nlm.nih.gov/gene/?term=22794 "BTZ, MLN51 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006518 22796 COG2 http://www.ncbi.nlm.nih.gov/gene/?term=22796 LDLC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006519 22796 COG2 http://www.ncbi.nlm.nih.gov/gene/?term=22796 LDLC mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006520 228003 Klhl41 http://www.ncbi.nlm.nih.gov/gene/?term=228003 "Gm112, Kbtbd10, SARCOSIN " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006521 228005 Ppig http://www.ncbi.nlm.nih.gov/gene/?term=228005 "AU019516, AU022200, B230312B02Rik, CYP, SRCyp " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006522 22800 RRAS2 http://www.ncbi.nlm.nih.gov/gene/?term=22800 TC21 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006523 22800 RRAS2 http://www.ncbi.nlm.nih.gov/gene/?term=22800 TC21 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006524 228012 Tlk1 http://www.ncbi.nlm.nih.gov/gene/?term=228012 4930545J15Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006525 228026 Pdk1 http://www.ncbi.nlm.nih.gov/gene/?term=228026 "B830012B01, D530020C15Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006526 22803 XRN2 http://www.ncbi.nlm.nih.gov/gene/?term=22803 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006527 22803 XRN2 http://www.ncbi.nlm.nih.gov/gene/?term=22803 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006528 22808 MRAS http://www.ncbi.nlm.nih.gov/gene/?term=22808 "M-RAs, R-RAS3, RRAS3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006529 22808 MRAS http://www.ncbi.nlm.nih.gov/gene/?term=22808 "M-RAs, R-RAS3, RRAS3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006530 22809 ATF5 http://www.ncbi.nlm.nih.gov/gene/?term=22809 "ATFX, HMFN0395 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006531 22809 ATF5 http://www.ncbi.nlm.nih.gov/gene/?term=22809 "ATFX, HMFN0395 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006532 22809 ATF5 http://www.ncbi.nlm.nih.gov/gene/?term=22809 "ATFX, HMFN0395 " mRNA Homo sapiens 26131922 Axon Brain In situ hybridization "Finally, Atf4 mRNA is found in adult axons of mice and human brains in the context of Abeta-induced neurodegeneration. " RLID00006533 2280 FKBP1A http://www.ncbi.nlm.nih.gov/gene/?term=2280 "FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006534 2280 FKBP1A http://www.ncbi.nlm.nih.gov/gene/?term=2280 "FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006535 2280 FKBP1A http://www.ncbi.nlm.nih.gov/gene/?term=2280 "FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006536 22818 COPZ1 http://www.ncbi.nlm.nih.gov/gene/?term=22818 "CGI-120, COPZ, HSPC181, zeta-COP, zeta1-COP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006537 22818 COPZ1 http://www.ncbi.nlm.nih.gov/gene/?term=22818 "CGI-120, COPZ, HSPC181, zeta-COP, zeta1-COP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006538 22818 COPZ1 http://www.ncbi.nlm.nih.gov/gene/?term=22818 "CGI-120, COPZ, HSPC181, zeta-COP, zeta1-COP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006539 22820 COPG1 http://www.ncbi.nlm.nih.gov/gene/?term=22820 COPG mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006540 22822 PHLDA1 http://www.ncbi.nlm.nih.gov/gene/?term=22822 "DT1P1B11, PHRIP, TDAG51 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006541 22822 PHLDA1 http://www.ncbi.nlm.nih.gov/gene/?term=22822 "DT1P1B11, PHRIP, TDAG51 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006542 22822 PHLDA1 http://www.ncbi.nlm.nih.gov/gene/?term=22822 "DT1P1B11, PHRIP, TDAG51 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006543 22823 MTF2 http://www.ncbi.nlm.nih.gov/gene/?term=22823 "M96, PCL2, TDRD19A, dJ976O13.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006544 22823 MTF2 http://www.ncbi.nlm.nih.gov/gene/?term=22823 "M96, PCL2, TDRD19A, dJ976O13.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006545 22824 HSPA4L http://www.ncbi.nlm.nih.gov/gene/?term=22824 "APG-1, HSPH3, Osp94 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006546 22824 HSPA4L http://www.ncbi.nlm.nih.gov/gene/?term=22824 "APG-1, HSPH3, Osp94 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006547 22824 HSPA4L http://www.ncbi.nlm.nih.gov/gene/?term=22824 "APG-1, HSPH3, Osp94 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006548 22826 DNAJC8 http://www.ncbi.nlm.nih.gov/gene/?term=22826 "HSPC331, SPF31 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006549 22826 DNAJC8 http://www.ncbi.nlm.nih.gov/gene/?term=22826 "HSPC331, SPF31 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006550 22827 PUF60 http://www.ncbi.nlm.nih.gov/gene/?term=22827 "FIR, RoBPI, SIAHBP1, VRJS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006551 22827 PUF60 http://www.ncbi.nlm.nih.gov/gene/?term=22827 "FIR, RoBPI, SIAHBP1, VRJS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006552 22828 SCAF8 http://www.ncbi.nlm.nih.gov/gene/?term=22828 RBM16 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006553 22834 ZNF652 http://www.ncbi.nlm.nih.gov/gene/?term=22834 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006554 22834 ZNF652 http://www.ncbi.nlm.nih.gov/gene/?term=22834 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006555 22834 ZNF652 http://www.ncbi.nlm.nih.gov/gene/?term=22834 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006556 228356 1110051M20Rik http://www.ncbi.nlm.nih.gov/gene/?term=228356 AI586322 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006557 228361 Ambra1 http://www.ncbi.nlm.nih.gov/gene/?term=228361 "2310079H06Rik, A130023A14, AA474864, AV021921, D030051N19Rik, mKIAA1736 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006558 22836 RHOBTB3 http://www.ncbi.nlm.nih.gov/gene/?term=22836 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006559 22836 RHOBTB3 http://www.ncbi.nlm.nih.gov/gene/?term=22836 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006560 22837 COBLL1 http://www.ncbi.nlm.nih.gov/gene/?term=22837 COBLR1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006561 22839 DLGAP4 http://www.ncbi.nlm.nih.gov/gene/?term=22839 "DAP-4, DAP4, DLP4, SAPAP-4, SAPAP4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006562 228410 Cstf3 http://www.ncbi.nlm.nih.gov/gene/?term=228410 "4732468G05Rik, C79532, CstF-77 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006563 228421 Kif18a http://www.ncbi.nlm.nih.gov/gene/?term=228421 "AU024633, B130001M12Rik, gcd2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006564 22843 PPM1E http://www.ncbi.nlm.nih.gov/gene/?term=22843 "CaMKP-N, POPX1, PP2CH, caMKN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006565 22843 PPM1E http://www.ncbi.nlm.nih.gov/gene/?term=22843 "CaMKP-N, POPX1, PP2CH, caMKN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006566 22845 DOLK http://www.ncbi.nlm.nih.gov/gene/?term=22845 "CDG1M, DK, DK1, SEC59, TMEM15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006567 22846 VASH1 http://www.ncbi.nlm.nih.gov/gene/?term=22846 KIAA1036 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006568 22847 ZNF507 http://www.ncbi.nlm.nih.gov/gene/?term=22847 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006569 22847 ZNF507 http://www.ncbi.nlm.nih.gov/gene/?term=22847 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006570 22848 AAK1 http://www.ncbi.nlm.nih.gov/gene/?term=22848 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006571 22848 AAK1 http://www.ncbi.nlm.nih.gov/gene/?term=22848 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006572 22848 AAK1 http://www.ncbi.nlm.nih.gov/gene/?term=22848 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006573 22850 ADNP2 http://www.ncbi.nlm.nih.gov/gene/?term=22850 ZNF508 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006574 22850 ADNP2 http://www.ncbi.nlm.nih.gov/gene/?term=22850 ZNF508 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006575 22850 ADNP2 http://www.ncbi.nlm.nih.gov/gene/?term=22850 ZNF508 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006576 22853 LMTK2 http://www.ncbi.nlm.nih.gov/gene/?term=22853 "AATYK2, BREK, KPI-2, KPI2, LMR2, PPP1R100, cprk, hBREK " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006577 228545 Vps18 http://www.ncbi.nlm.nih.gov/gene/?term=228545 9930024E13Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006578 22858 ICK http://www.ncbi.nlm.nih.gov/gene/?term=22858 "ECO, LCK2, MRK " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006579 22858 ICK http://www.ncbi.nlm.nih.gov/gene/?term=22858 "ECO, LCK2, MRK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006580 22858 ICK http://www.ncbi.nlm.nih.gov/gene/?term=22858 "ECO, LCK2, MRK " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006581 22858 ICK http://www.ncbi.nlm.nih.gov/gene/?term=22858 "ECO, LCK2, MRK " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006582 22859 ADGRL1 http://www.ncbi.nlm.nih.gov/gene/?term=22859 "CIRL1, CL1, LEC2, LPHN1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006583 228608 Smox http://www.ncbi.nlm.nih.gov/gene/?term=228608 "B130066H01Rik, PAO, PAOh1, SMO " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006584 22861 NLRP1 http://www.ncbi.nlm.nih.gov/gene/?term=22861 "CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, NAC, NALP1, PP1044, SLEV1, VAMAS1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006585 22862 FNDC3A http://www.ncbi.nlm.nih.gov/gene/?term=22862 "FNDC3, HUGO, bA203I16.1, bA203I16.5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006586 22862 FNDC3A http://www.ncbi.nlm.nih.gov/gene/?term=22862 "FNDC3, HUGO, bA203I16.1, bA203I16.5 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006587 22864 R3HDM2 http://www.ncbi.nlm.nih.gov/gene/?term=22864 "CAG6, PR01365 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006588 228684 Sel1l2 http://www.ncbi.nlm.nih.gov/gene/?term=228684 Gm118 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006589 22868 FASTKD2 http://www.ncbi.nlm.nih.gov/gene/?term=22868 KIAA0971 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006590 22869 ZNF510 http://www.ncbi.nlm.nih.gov/gene/?term=22869 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006591 2286 FKBP2 http://www.ncbi.nlm.nih.gov/gene/?term=2286 "FKBP-13, PPIase " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006592 2286 FKBP2 http://www.ncbi.nlm.nih.gov/gene/?term=2286 "FKBP-13, PPIase " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006593 22870 PPP6R1 http://www.ncbi.nlm.nih.gov/gene/?term=22870 "KIAA1115, PP6R1, SAP190, SAPS1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006594 22872 SEC31A http://www.ncbi.nlm.nih.gov/gene/?term=22872 "ABP125, ABP130, HSPC275, HSPC334, SEC31L1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006595 22872 SEC31A http://www.ncbi.nlm.nih.gov/gene/?term=22872 "ABP125, ABP130, HSPC275, HSPC334, SEC31L1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006596 22872 SEC31A http://www.ncbi.nlm.nih.gov/gene/?term=22872 "ABP125, ABP130, HSPC275, HSPC334, SEC31L1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006597 22873 DZIP1 http://www.ncbi.nlm.nih.gov/gene/?term=22873 "DZIP, DZIPt1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006598 22873 DZIP1 http://www.ncbi.nlm.nih.gov/gene/?term=22873 "DZIP, DZIPt1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006599 22874 PLEKHA6 http://www.ncbi.nlm.nih.gov/gene/?term=22874 "PEPP-3, PEPP3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006600 228756 Cstl1 http://www.ncbi.nlm.nih.gov/gene/?term=228756 "RCET1, RCET2, RCET3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006601 228765 Sdcbp2 http://www.ncbi.nlm.nih.gov/gene/?term=228765 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006602 228769 Psmf1 http://www.ncbi.nlm.nih.gov/gene/?term=228769 "AW048666, BC012260, PI31 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006603 22876 INPP5F http://www.ncbi.nlm.nih.gov/gene/?term=22876 "MSTP007, MSTPO47, SAC2, hSAC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006604 228775 Trib3 http://www.ncbi.nlm.nih.gov/gene/?term=228775 "Ifld2, Nipk, SINK, SKIP3, TRB-3, Trb3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006605 228785 Mylk2 http://www.ncbi.nlm.nih.gov/gene/?term=228785 "9830004H17Rik, BB138278 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006606 22878 TRAPPC8 http://www.ncbi.nlm.nih.gov/gene/?term=22878 "GSG1, HsT2706, KIAA1012, TRS85 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006607 22878 TRAPPC8 http://www.ncbi.nlm.nih.gov/gene/?term=22878 "GSG1, HsT2706, KIAA1012, TRS85 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006608 228790 Asxl1 http://www.ncbi.nlm.nih.gov/gene/?term=228790 mKIAA0978 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006609 22879 MON1B http://www.ncbi.nlm.nih.gov/gene/?term=22879 "HSRG1, SAND2, SRG1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006610 2287 FKBP3 http://www.ncbi.nlm.nih.gov/gene/?term=2287 "FKBP-25, FKBP-3, FKBP25, PPIase " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006611 22880 MORC2 http://www.ncbi.nlm.nih.gov/gene/?term=22880 "CMT2Z, ZCW3, ZCWCC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006612 22880 MORC2 http://www.ncbi.nlm.nih.gov/gene/?term=22880 "CMT2Z, ZCW3, ZCWCC1 " mRNA Homo sapiens 25630241 Cytoplasm Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00006613 22880 MORC2 http://www.ncbi.nlm.nih.gov/gene/?term=22880 "CMT2Z, ZCW3, ZCWCC1 " mRNA Homo sapiens 25630241 Nucleus Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00006614 228836 Dlgap4 http://www.ncbi.nlm.nih.gov/gene/?term=228836 "AI225853, BC024558, DAP-4, DAP4, SAPAP-4, Sapap4, WBP16 " mRNA Mus musculus 18539120 Dendrite Neuron Fluorescence in situ hybridization Figure 5d: Dendritic SAPAP4 mRNA localization in response to DHPG (11DIV). RLID00006615 228836 Dlgap4 http://www.ncbi.nlm.nih.gov/gene/?term=228836 "AI225853, BC024558, DAP-4, DAP4, SAPAP-4, Sapap4, WBP16 " mRNA Mus musculus 18539120 Synapse Brain qRT-PCR "The mRNA targets reduced in Kif5 association included genes involved in actin remodeling at synapses (cofilin phosphatase (PP2Ac); p116-RIP), synapse-associated signaling (DAG1;RGS5) and synapse structure (SAPAP4; CaMKIIa; MAP1b). Not all mRNAs were significantly reduced in Kif5 IPs, as OCRL1 mRNA was similar in KO brain (P>0.05, n=8). " RLID00006616 228839 Tgif2 http://www.ncbi.nlm.nih.gov/gene/?term=228839 "4921501K24, 5730599O09Rik, C80753, C81206 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006617 22883 CLSTN1 http://www.ncbi.nlm.nih.gov/gene/?term=22883 "ALC-ALPHA, CDHR12, CST-1, CSTN1, PIK3CD, XB31alpha, alcalpha1, alcalpha2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006618 22883 CLSTN1 http://www.ncbi.nlm.nih.gov/gene/?term=22883 "ALC-ALPHA, CDHR12, CST-1, CSTN1, PIK3CD, XB31alpha, alcalpha1, alcalpha2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006619 22883 CLSTN1 http://www.ncbi.nlm.nih.gov/gene/?term=22883 "ALC-ALPHA, CDHR12, CST-1, CSTN1, PIK3CD, XB31alpha, alcalpha1, alcalpha2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006620 22884 WDR37 http://www.ncbi.nlm.nih.gov/gene/?term=22884 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006621 228858 Gdap1l1 http://www.ncbi.nlm.nih.gov/gene/?term=228858 Gdap1l mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006622 228866 Pcif1 http://www.ncbi.nlm.nih.gov/gene/?term=228866 "2310022K11Rik, C20orf67, F730014I05Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006623 22887 FOXJ3 http://www.ncbi.nlm.nih.gov/gene/?term=22887 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006624 22887 FOXJ3 http://www.ncbi.nlm.nih.gov/gene/?term=22887 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006625 228880 Zmynd8 http://www.ncbi.nlm.nih.gov/gene/?term=228880 "1110013E22Rik, 2010005I16Rik, 3632413B07Rik, AI316811, AL024039, Prkcbp1, RACK7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006626 22888 UBOX5 http://www.ncbi.nlm.nih.gov/gene/?term=22888 "RNF37, UBCE7IP5, UIP5, hUIP5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006627 22889 KIAA0907 http://www.ncbi.nlm.nih.gov/gene/?term=22889 BLOM7 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006628 2288 FKBP4 http://www.ncbi.nlm.nih.gov/gene/?term=2288 "FKBP51, FKBP52, FKBP59, HBI, Hsp56, PPIase, p52 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006629 22890 ZBTB1 http://www.ncbi.nlm.nih.gov/gene/?term=22890 ZNF909 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006630 228911 Tshz2 http://www.ncbi.nlm.nih.gov/gene/?term=228911 "2900073F20Rik, B830045G17, Mtsh2, Sdccag33l, Tsh2, Zfp218, mKIAA4248, teashirt2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006631 22894 DIS3 http://www.ncbi.nlm.nih.gov/gene/?term=22894 "2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006632 228960 Stx16 http://www.ncbi.nlm.nih.gov/gene/?term=228960 "4930401D03, 5430410K23Rik, 6330500A18Rik, AI648908, AW553605, Syn16 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006633 22897 CEP164 http://www.ncbi.nlm.nih.gov/gene/?term=22897 NPHP15 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006634 228983 Osbpl2 http://www.ncbi.nlm.nih.gov/gene/?term=228983 "C130070J12Rik, ORP-2, Orp2, mKIAA0772 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006635 2289 FKBP5 http://www.ncbi.nlm.nih.gov/gene/?term=2289 "AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006636 2289 FKBP5 http://www.ncbi.nlm.nih.gov/gene/?term=2289 "AIG61, FKBP54, P54, PPIase, Ptg-10, FKBP5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006637 22900 CARD8 http://www.ncbi.nlm.nih.gov/gene/?term=22900 "CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006638 22900 CARD8 http://www.ncbi.nlm.nih.gov/gene/?term=22900 "CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006639 22902 RUFY3 http://www.ncbi.nlm.nih.gov/gene/?term=22902 "RIPX, SINGAR1, ZFYVE30 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006640 22903 BTBD3 http://www.ncbi.nlm.nih.gov/gene/?term=22903 dJ742J24.1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006641 22904 SBNO2 http://www.ncbi.nlm.nih.gov/gene/?term=22904 "KIAA0963, SNO, STNO " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006642 22906 TRAK1 http://www.ncbi.nlm.nih.gov/gene/?term=22906 "MILT1, OIP106 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006643 22907 DHX30 http://www.ncbi.nlm.nih.gov/gene/?term=22907 "DDX30, RETCOR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006644 22907 DHX30 http://www.ncbi.nlm.nih.gov/gene/?term=22907 "DDX30, RETCOR " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006645 22907 DHX30 http://www.ncbi.nlm.nih.gov/gene/?term=22907 "DDX30, RETCOR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006646 22908 SACM1L http://www.ncbi.nlm.nih.gov/gene/?term=22908 SAC1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006647 22908 SACM1L http://www.ncbi.nlm.nih.gov/gene/?term=22908 SAC1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006648 22908 SACM1L http://www.ncbi.nlm.nih.gov/gene/?term=22908 SAC1 mRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00006649 22908 SACM1L http://www.ncbi.nlm.nih.gov/gene/?term=22908 SAC1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006650 22909 FAN1 http://www.ncbi.nlm.nih.gov/gene/?term=22909 "KIAA1018, KMIN, MTMR15, hFAN1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006651 22909 FAN1 http://www.ncbi.nlm.nih.gov/gene/?term=22909 "KIAA1018, KMIN, MTMR15, hFAN1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006652 2290 FOXG1 http://www.ncbi.nlm.nih.gov/gene/?term=2290 "BF1, BF2, FHKL3, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF-2, HBF-3, HBF-G2, HBF2, HFK1, HFK2, HFK3, KHL2, QIN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006653 22913 RALY http://www.ncbi.nlm.nih.gov/gene/?term=22913 "HNRPCL2, P542 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006654 22913 RALY http://www.ncbi.nlm.nih.gov/gene/?term=22913 "HNRPCL2, P542 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006655 22914 KLRK1 http://www.ncbi.nlm.nih.gov/gene/?term=22914 "CD314, D12S2489E, KLR, NKG2-D, NKG2D " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006656 22916 NCBP2 http://www.ncbi.nlm.nih.gov/gene/?term=22916 "CBC2, CBP20, NIP1, PIG55 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006657 22916 NCBP2 http://www.ncbi.nlm.nih.gov/gene/?term=22916 "CBC2, CBP20, NIP1, PIG55 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006658 22919 MAPRE1 http://www.ncbi.nlm.nih.gov/gene/?term=22919 EB1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006659 22919 MAPRE1 http://www.ncbi.nlm.nih.gov/gene/?term=22919 EB1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006660 22919 MAPRE1 http://www.ncbi.nlm.nih.gov/gene/?term=22919 EB1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006661 22920 KIFAP3 http://www.ncbi.nlm.nih.gov/gene/?term=22920 "FLA3, KAP-1, KAP-3, KAP3, SMAP, Smg-GDS, dJ190I16.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006662 22921 MSRB2 http://www.ncbi.nlm.nih.gov/gene/?term=22921 "CBS-1, CBS1, CGI-131, MSRB, PILB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006663 22921 MSRB2 http://www.ncbi.nlm.nih.gov/gene/?term=22921 "CBS-1, CBS1, CGI-131, MSRB, PILB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006664 229227 4932438A13Rik http://www.ncbi.nlm.nih.gov/gene/?term=229227 "4732443H21, B830039D19Rik, D630029K19Rik, FSA, Kiaa1109, Tweek " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006665 22924 MAPRE3 http://www.ncbi.nlm.nih.gov/gene/?term=22924 "EB3, EBF3, EBF3-S, RP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006666 22924 MAPRE3 http://www.ncbi.nlm.nih.gov/gene/?term=22924 "EB3, EBF3, EBF3-S, RP3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006667 22925 PLA2R1 http://www.ncbi.nlm.nih.gov/gene/?term=22925 "CLEC13C, PLA2-R, PLA2G1R, PLA2IR, PLA2R " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006668 22926 ATF6 http://www.ncbi.nlm.nih.gov/gene/?term=22926 "ACHM7, ATF6A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006669 22926 ATF6 http://www.ncbi.nlm.nih.gov/gene/?term=22926 "ACHM7A, ATF6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006670 229279 Hnrnpa3 http://www.ncbi.nlm.nih.gov/gene/?term=229279 "2410013L13Rik, 2610209F03Rik, 2610510D13Rik, Hnrpa3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006671 229279 Hnrnpa3 http://www.ncbi.nlm.nih.gov/gene/?term=229279 "2410013L13Rik, 2610209F03Rik, 2610510D13Rik, Hnrpa3 " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00006672 22929 SEPHS1 http://www.ncbi.nlm.nih.gov/gene/?term=22929 "SELD, SPS, SPS1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006673 22930 RAB3GAP1 http://www.ncbi.nlm.nih.gov/gene/?term=22930 "P130, RAB3GAP, RAB3GAP130, WARBM1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006674 22930 RAB3GAP1 http://www.ncbi.nlm.nih.gov/gene/?term=22930 "P130, RAB3GAP30, WARBM1, RAB3GAP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006675 229317 Eif2a http://www.ncbi.nlm.nih.gov/gene/?term=229317 "D030048D22, D3Ertd194e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006676 22931 RAB18 http://www.ncbi.nlm.nih.gov/gene/?term=22931 "RAB18LI1, WARBM3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006677 22931 RAB18 http://www.ncbi.nlm.nih.gov/gene/?term=22931 "RAB18LI1, WARBM3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006678 22932 POMZP3 http://www.ncbi.nlm.nih.gov/gene/?term=22932 "POM-ZP3, POM121 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006679 22933 SIRT2 http://www.ncbi.nlm.nih.gov/gene/?term=22933 "SIR2, SIR2L, SIR2L2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006680 22934 RPIA http://www.ncbi.nlm.nih.gov/gene/?term=22934 "RPI, RPIAD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006681 22934 RPIA http://www.ncbi.nlm.nih.gov/gene/?term=22934 "RPID, RPIA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006682 229357 Gpr149 http://www.ncbi.nlm.nih.gov/gene/?term=229357 "9630018L10Rik, Ieda, PGR10, R35 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006683 229363 Gmps http://www.ncbi.nlm.nih.gov/gene/?term=229363 "AA591640, AI047208 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006684 22936 ELL2 http://www.ncbi.nlm.nih.gov/gene/?term=22936 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006685 22937 SCAP http://www.ncbi.nlm.nih.gov/gene/?term=22937 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006686 22937 SCAP http://www.ncbi.nlm.nih.gov/gene/?term=22937 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006687 22938 SNW1 http://www.ncbi.nlm.nih.gov/gene/?term=22938 "Bx42, NCOA-62, PRPF45, Prp45, SKIIP, SKIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006688 22938 SNW1 http://www.ncbi.nlm.nih.gov/gene/?term=22938 "Bx42, NCOA-62, PRPF45, Prp45, SKIIP, SKIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006689 229473 D930015E06Rik http://www.ncbi.nlm.nih.gov/gene/?term=229473 "Kiaa0922, mKIAA0922 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006690 229474 Fhdc1 http://www.ncbi.nlm.nih.gov/gene/?term=229474 "6330505N24Rik, Gm126 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006691 229488 Fam160a1 http://www.ncbi.nlm.nih.gov/gene/?term=229488 9930021J17Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006692 22948 CCT5 http://www.ncbi.nlm.nih.gov/gene/?term=22948 "CCT-epsilon, CCTE, HEL-S-69, PNAS-102, TCP-1-epsilon " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006693 22948 CCT5 http://www.ncbi.nlm.nih.gov/gene/?term=22948 "CCT-epsilon, CCTE, HEL-S-69, PNAS-102, TCP-1-epsilon " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006694 22948 CCT5 http://www.ncbi.nlm.nih.gov/gene/?term=22948 "CCT-epsilon, CCTE, HEL-S-69, PNAS-102, TCP-1-epsilon " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006695 2294 FOXF1 http://www.ncbi.nlm.nih.gov/gene/?term=2294 "ACDMPV, FKHL5, FREAC1 " mRNA Homo sapiens 25630241 Cytoplasm Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00006696 2294 FOXF1 http://www.ncbi.nlm.nih.gov/gene/?term=2294 "ACDMPV, FKHL5, FREAC1 " mRNA Homo sapiens 25630241 Nucleus Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00006697 229517 Slc25a44 http://www.ncbi.nlm.nih.gov/gene/?term=229517 "6720482A19, B430110G05Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006698 229521 Syt11 http://www.ncbi.nlm.nih.gov/gene/?term=229521 "1500004A13Rik, 3632445O20Rik, 5430404N14Rik, 6530420C11Rik, AI851970 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006699 229521 Syt11 http://www.ncbi.nlm.nih.gov/gene/?term=229521 "1500004A13Rik, 3632445O20Rik, 5430404N14Rik, 6530420C11Rik, AI851970 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006700 229524 Msto1 http://www.ncbi.nlm.nih.gov/gene/?term=229524 "BC008103, mst " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006701 22955 SCMH1 http://www.ncbi.nlm.nih.gov/gene/?term=22955 Scml3 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006702 229562 Sprr4 http://www.ncbi.nlm.nih.gov/gene/?term=229562 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006703 229574 Flg2 http://www.ncbi.nlm.nih.gov/gene/?term=229574 EG229574 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006704 229663 Csde1 http://www.ncbi.nlm.nih.gov/gene/?term=229663 "AA960392, BC016898, D3Jfr1, mKIAA0885, unr " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006705 229663 Csde1 http://www.ncbi.nlm.nih.gov/gene/?term=229663 "AA960392, BC016898, D3Jfr1, mKIAA0885, unr " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006706 2296 FOXC1 http://www.ncbi.nlm.nih.gov/gene/?term=2296 "ARA, FKHL7, FREAC-3, FREAC3, IGDA, IHG1, IRID1, RIEG3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006707 229700 Rbm15 http://www.ncbi.nlm.nih.gov/gene/?term=229700 "C230088J01Rik, mKIAA1438 " mRNA Mus musculus 26190105 Nucleus Embryotem cell Microscopy "Figure 6: 3DSIM Showing that Xist RNA, Rbm15, Wtap, and Spen Co-localize within Perichromatin Spaces. Data are collected from Figure 6. " RLID00006708 229709 Ahcyl1 http://www.ncbi.nlm.nih.gov/gene/?term=229709 "1110034F20Rik, AA409031, AA414901, Ahcy-rs3, DCAL, Irbit " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006709 229722 5330417C22Rik http://www.ncbi.nlm.nih.gov/gene/?term=229722 "BB183350, mKIAA1324 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006710 229731 Slc25a24 http://www.ncbi.nlm.nih.gov/gene/?term=229731 2610016M12Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006711 22974 TPX2 http://www.ncbi.nlm.nih.gov/gene/?term=22974 "C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006712 22974 TPX2 http://www.ncbi.nlm.nih.gov/gene/?term=22974 "C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006713 22976 PAXIP1 http://www.ncbi.nlm.nih.gov/gene/?term=22976 "CAGF28, CAGF29, PACIP1, PAXIP1L, PTIP, TNRC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006714 22976 PAXIP1 http://www.ncbi.nlm.nih.gov/gene/?term=22976 "CAGF28, CAGF29, PACIP1L, PTIP, TNRC2, PAXIP1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006715 22977 AKR7A3 http://www.ncbi.nlm.nih.gov/gene/?term=22977 AFAR2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006716 229780 Trmt13 http://www.ncbi.nlm.nih.gov/gene/?term=229780 "4631408H19Rik, A330067P21, A930028L21Rik, Ccdc76 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006717 229782 Slc35a3 http://www.ncbi.nlm.nih.gov/gene/?term=229782 2310050P13Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006718 22978 NT5C2 http://www.ncbi.nlm.nih.gov/gene/?term=22978 "GMP, NT5B, PNT5, SPG45, SPG65, cN-II " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006719 22978 NT5C2 http://www.ncbi.nlm.nih.gov/gene/?term=22978 "GMP, NT5B, PNT5, SPG45, SPG65, cN-II " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006720 229791 Plppr4 http://www.ncbi.nlm.nih.gov/gene/?term=229791 "A330086D10, D3Bwg0562e, Lppr4, PRG-1, mKIAA0455 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006721 22979 EFR3B http://www.ncbi.nlm.nih.gov/gene/?term=22979 KIAA0953 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006722 22979 EFR3B http://www.ncbi.nlm.nih.gov/gene/?term=22979 KIAA0953 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006723 2297 FOXD1 http://www.ncbi.nlm.nih.gov/gene/?term=2297 "FKHL8, FREAC-4, FREAC4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006724 2297 FOXD1 http://www.ncbi.nlm.nih.gov/gene/?term=2297 "FKHL8, FREAC-4, FREAC4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006725 2297 FOXD1 http://www.ncbi.nlm.nih.gov/gene/?term=2297 "FKHL8, FREAC-4, FREAC4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006726 22980 TCF25 http://www.ncbi.nlm.nih.gov/gene/?term=22980 "FKSG26, Hulp1, NULP1, PRO2620, hKIAA1049 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006727 22980 TCF25 http://www.ncbi.nlm.nih.gov/gene/?term=22980 "FKSG26, Hulp1, NULP1, PRO2620, hKIAA1049 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006728 22983 MAST1 http://www.ncbi.nlm.nih.gov/gene/?term=22983 "SAST, SAST170 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006729 22984 PDCD11 http://www.ncbi.nlm.nih.gov/gene/?term=22984 "ALG-4, ALG4, NFBP, RRP5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006730 22985 ACIN1 http://www.ncbi.nlm.nih.gov/gene/?term=22985 "ACINUS, ACN, fSAP152 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006731 22985 ACIN1 http://www.ncbi.nlm.nih.gov/gene/?term=22985 "ACINUS, ACN, fSAP152 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006732 22985 ACIN1 http://www.ncbi.nlm.nih.gov/gene/?term=22985 "ACINUS, ACN, fSAP152 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006733 229905 Ccbl2 http://www.ncbi.nlm.nih.gov/gene/?term=229905 "KATIII, Kat3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006734 22990 PCNX1 http://www.ncbi.nlm.nih.gov/gene/?term=22990 "PCNX, PCNXL1, pecanex " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006735 22990 PCNX1 http://www.ncbi.nlm.nih.gov/gene/?term=22990 "PCNX, PCNXL1, pecanex " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006736 22992 KDM2A http://www.ncbi.nlm.nih.gov/gene/?term=22992 "CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006737 22992 KDM2A http://www.ncbi.nlm.nih.gov/gene/?term=22992 "CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006738 22993 HMGXB3 http://www.ncbi.nlm.nih.gov/gene/?term=22993 "HMGX3, SMF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006739 22995 CEP152 http://www.ncbi.nlm.nih.gov/gene/?term=22995 "MCPH4, MCPH9, SCKL5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006740 22999 RIMS1 http://www.ncbi.nlm.nih.gov/gene/?term=22999 "CORD7, RAB3IP2, RIM, RIM1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006741 229 ALDOB http://www.ncbi.nlm.nih.gov/gene/?term=229 "ALDB, ALDO2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006742 23001 WDFY3 http://www.ncbi.nlm.nih.gov/gene/?term=23001 "ALFY, ZFYVE25 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006743 23002 DAAM1 http://www.ncbi.nlm.nih.gov/gene/?term=23002 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006744 23002 DAAM1 http://www.ncbi.nlm.nih.gov/gene/?term=23002 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006745 23005 MAPKBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23005 "JNKBP-1, JNKBP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006746 23008 KLHDC10 http://www.ncbi.nlm.nih.gov/gene/?term=23008 slim mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006747 23008 KLHDC10 http://www.ncbi.nlm.nih.gov/gene/?term=23008 slim mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006748 23011 RAB21 http://www.ncbi.nlm.nih.gov/gene/?term=23011 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006749 23011 RAB21 http://www.ncbi.nlm.nih.gov/gene/?term=23011 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006750 23011 RAB21 http://www.ncbi.nlm.nih.gov/gene/?term=23011 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006751 230125 Slc25a51 http://www.ncbi.nlm.nih.gov/gene/?term=230125 "9130208E07Rik, D130005A03Rik, Gm138, Mcart1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006752 230126 Shb http://www.ncbi.nlm.nih.gov/gene/?term=230126 BC028832 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006753 23012 STK38L http://www.ncbi.nlm.nih.gov/gene/?term=23012 NDR2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006754 23012 STK38L http://www.ncbi.nlm.nih.gov/gene/?term=23012 NDR2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006755 23013 SPEN http://www.ncbi.nlm.nih.gov/gene/?term=23013 "HIAA0929, MINT, RBM15C, SHARP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006756 23013 SPEN http://www.ncbi.nlm.nih.gov/gene/?term=23013 "HIAA0929, MINT, RBM15C, SHARP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006757 23014 FBXO21 http://www.ncbi.nlm.nih.gov/gene/?term=23014 FBX21 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006758 23014 FBXO21 http://www.ncbi.nlm.nih.gov/gene/?term=23014 FBX21 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006759 230157 Tmeff1 http://www.ncbi.nlm.nih.gov/gene/?term=230157 "A830033E11, M7365, Tr1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006760 23015 GOLGA8A http://www.ncbi.nlm.nih.gov/gene/?term=23015 GM88 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006761 230161 Acnat1 http://www.ncbi.nlm.nih.gov/gene/?term=230161 AI132189 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006762 23016 EXOSC7 http://www.ncbi.nlm.nih.gov/gene/?term=23016 "EAP1, RRP42, Rrp42p, hRrp42p, p8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006763 23019 CNOT1 http://www.ncbi.nlm.nih.gov/gene/?term=23019 "AD-005, CDC39, NOT1, NOT1H " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006764 23019 CNOT1 http://www.ncbi.nlm.nih.gov/gene/?term=23019 "AD-005, CDC39, NOT1, NOT1H " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006765 23020 SNRNP200 http://www.ncbi.nlm.nih.gov/gene/?term=23020 "ASCC3L1, BRR2, HELIC2, RP33, U5-200KD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006766 23022 PALLD http://www.ncbi.nlm.nih.gov/gene/?term=23022 "CGI-151, CGI151, MYN, PNCA1, SIH002 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006767 230233 Ikbkap http://www.ncbi.nlm.nih.gov/gene/?term=230233 "3110040G09Rik, 6030413P05, C78473, Elp1, IKAP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006768 23023 TMCC1 http://www.ncbi.nlm.nih.gov/gene/?term=23023 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006769 230257 Ptbp3 http://www.ncbi.nlm.nih.gov/gene/?term=230257 "5830471K22Rik, AA407443, AI462022, AW107884, C86549, Rod1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006770 230259 E130308A19Rik http://www.ncbi.nlm.nih.gov/gene/?term=230259 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006771 230259 E130308A19Rik http://www.ncbi.nlm.nih.gov/gene/?term=230259 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006772 23028 KDM1A http://www.ncbi.nlm.nih.gov/gene/?term=23028 "AOF2, BHC110, CPRF, KDM1, LSD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006773 23028 KDM1A http://www.ncbi.nlm.nih.gov/gene/?term=23028 "AOF2, BHC110, CPRF, KDM1, LSD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006774 23029 RBM34 http://www.ncbi.nlm.nih.gov/gene/?term=23029 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006775 23030 KDM4B http://www.ncbi.nlm.nih.gov/gene/?term=23030 "JMJD2B, TDRD14B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006776 23031 MAST3 http://www.ncbi.nlm.nih.gov/gene/?term=23031 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006777 23031 MAST3 http://www.ncbi.nlm.nih.gov/gene/?term=23031 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006778 23031 MAST3 http://www.ncbi.nlm.nih.gov/gene/?term=23031 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006779 23032 USP33 http://www.ncbi.nlm.nih.gov/gene/?term=23032 VDU1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006780 23032 USP33 http://www.ncbi.nlm.nih.gov/gene/?term=23032 VDU1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006781 23032 USP33 http://www.ncbi.nlm.nih.gov/gene/?term=23032 VDU1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006782 23033 DOPEY1 http://www.ncbi.nlm.nih.gov/gene/?term=23033 "DOP1, KIAA1117, dJ202D23.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006783 23036 ZNF292 http://www.ncbi.nlm.nih.gov/gene/?term=23036 "Nbla00365, ZFP292, ZN-16, Zn-15, bA393I2.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006784 23036 ZNF292 http://www.ncbi.nlm.nih.gov/gene/?term=23036 "Nbla00365, ZFP292, ZN-16, Zn-15, bA393I2.3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006785 230376 Haus6 http://www.ncbi.nlm.nih.gov/gene/?term=230376 "6230416J20Rik, 9830144E06, D4Ertd27e, mKIAA1574 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006786 23038 WDTC1 http://www.ncbi.nlm.nih.gov/gene/?term=23038 "ADP, DCAF9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006787 23039 XPO7 http://www.ncbi.nlm.nih.gov/gene/?term=23039 "EXP7, RANBP16 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006788 23039 XPO7 http://www.ncbi.nlm.nih.gov/gene/?term=23039 "EXP7, RANBP16 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006789 23039 XPO7 http://www.ncbi.nlm.nih.gov/gene/?term=23039 "EXP7, RANBP16 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006790 23041 MON2 http://www.ncbi.nlm.nih.gov/gene/?term=23041 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006791 23041 MON2 http://www.ncbi.nlm.nih.gov/gene/?term=23041 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006792 23042 PDXDC1 http://www.ncbi.nlm.nih.gov/gene/?term=23042 LP8165 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006793 23042 PDXDC1 http://www.ncbi.nlm.nih.gov/gene/?term=23042 LP8165 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006794 23043 TNIK http://www.ncbi.nlm.nih.gov/gene/?term=23043 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006795 23043 TNIK http://www.ncbi.nlm.nih.gov/gene/?term=23043 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006796 23046 KIF21B http://www.ncbi.nlm.nih.gov/gene/?term=23046 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006797 23048 FNBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23048 FBP17 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006798 23048 FNBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23048 FBP17 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006799 23048 FNBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23048 FBP17 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006800 23048 FNBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23048 FBP17 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006801 23049 SMG1 http://www.ncbi.nlm.nih.gov/gene/?term=23049 "61E3.4, ATX, LIP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006802 23049 SMG1 http://www.ncbi.nlm.nih.gov/gene/?term=23049 "61E3.4, ATX, LIP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006803 23049 SMG1 http://www.ncbi.nlm.nih.gov/gene/?term=23049 "61E3.4, ATX, LIP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006804 23051 ZHX3 http://www.ncbi.nlm.nih.gov/gene/?term=23051 TIX1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006805 23052 ENDOD1 http://www.ncbi.nlm.nih.gov/gene/?term=23052 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006806 23052 ENDOD1 http://www.ncbi.nlm.nih.gov/gene/?term=23052 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006807 23053 ZSWIM8 http://www.ncbi.nlm.nih.gov/gene/?term=23053 KIAA0913 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006808 23054 NCOA6 http://www.ncbi.nlm.nih.gov/gene/?term=23054 "AIB3, ASC2, NRC, PRIP, RAP250, TRBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006809 230558 C8a http://www.ncbi.nlm.nih.gov/gene/?term=230558 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006810 230594 Zcchc11 http://www.ncbi.nlm.nih.gov/gene/?term=230594 "6030404K05Rik, 9230115F04Rik, PPAPD3, mKIAA0191 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006811 230598 Nrd1 http://www.ncbi.nlm.nih.gov/gene/?term=230598 "2600011I06Rik, AI875733, NRD-C, Nrdc " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006812 2305 FOXM1 http://www.ncbi.nlm.nih.gov/gene/?term=2305 "FKHL16, FOXM1B, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TRIDENT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006813 2305 FOXM1 http://www.ncbi.nlm.nih.gov/gene/?term=2305 "FKHL16B, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TRIDENT, FOXM1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006814 230603 Ttc39a http://www.ncbi.nlm.nih.gov/gene/?term=230603 4922503N01Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006815 23060 ZNF609 http://www.ncbi.nlm.nih.gov/gene/?term=23060 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006816 23061 TBC1D9B http://www.ncbi.nlm.nih.gov/gene/?term=23061 GRAMD9B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006817 23061 TBC1D9B http://www.ncbi.nlm.nih.gov/gene/?term=23061 GRAMD9B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006818 23062 GGA2 http://www.ncbi.nlm.nih.gov/gene/?term=23062 VEAR mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006819 23062 GGA2 http://www.ncbi.nlm.nih.gov/gene/?term=23062 VEAR mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006820 23062 GGA2 http://www.ncbi.nlm.nih.gov/gene/?term=23062 VEAR mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006821 23063 WAPL http://www.ncbi.nlm.nih.gov/gene/?term=23063 "FOE, KIAA0261, WAPAL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006822 23064 SETX http://www.ncbi.nlm.nih.gov/gene/?term=23064 "ALS4, AOA2, SCAR1, bA479K20.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006823 23064 SETX http://www.ncbi.nlm.nih.gov/gene/?term=23064 "ALS4, AOA2, SCAR1, bA479K20.2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006824 23064 SETX http://www.ncbi.nlm.nih.gov/gene/?term=23064 "ALS4, AOA2, SCAR1, bA479K20.2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006825 230654 Lrrc41 http://www.ncbi.nlm.nih.gov/gene/?term=230654 "AA409966, AW555107, D630045E04Rik, D730026A16Rik, MUF1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006826 230657 Tmem69 http://www.ncbi.nlm.nih.gov/gene/?term=230657 A630048M13Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006827 23065 EMC1 http://www.ncbi.nlm.nih.gov/gene/?term=23065 KIAA0090 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006828 23065 EMC1 http://www.ncbi.nlm.nih.gov/gene/?term=23065 "CAVIPMR, KIAA0090 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006829 23070 CMTR1 http://www.ncbi.nlm.nih.gov/gene/?term=23070 "FTSJD2, KIAA0082, MTr1, hMTr1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006830 23070 CMTR1 http://www.ncbi.nlm.nih.gov/gene/?term=23070 "FTSJD2, KIAA0082, MTr1, hMTr1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006831 23071 ERP44 http://www.ncbi.nlm.nih.gov/gene/?term=23071 "PDIA10, TXNDC4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006832 230721 Pabpc4 http://www.ncbi.nlm.nih.gov/gene/?term=230721 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006833 23072 HECW1 http://www.ncbi.nlm.nih.gov/gene/?term=23072 NEDL1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006834 230734 Yrdc http://www.ncbi.nlm.nih.gov/gene/?term=230734 "AV303379, BC023823, IRIP, ITIP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006835 230737 Gnl2 http://www.ncbi.nlm.nih.gov/gene/?term=230737 "BC003262, HUMAUANTIG, Ngp-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006836 23074 UHRF1BP1L http://www.ncbi.nlm.nih.gov/gene/?term=23074 SHIP164 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006837 23074 UHRF1BP1L http://www.ncbi.nlm.nih.gov/gene/?term=23074 SHIP164 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006838 230752 Eva1b http://www.ncbi.nlm.nih.gov/gene/?term=230752 "2610027C15Rik, Fam176b " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006839 230753 Thrap3 http://www.ncbi.nlm.nih.gov/gene/?term=230753 "9330151F09Rik, B230333E16Rik, Trap150 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006840 230757 5730409E04Rik http://www.ncbi.nlm.nih.gov/gene/?term=230757 "7530403E16Rik, AI849033 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006841 23076 RRP1B http://www.ncbi.nlm.nih.gov/gene/?term=23076 "KIAA0179, NNP1L, Nnp1, PPP1R136, RRP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006842 23076 RRP1B http://www.ncbi.nlm.nih.gov/gene/?term=23076 "KIAA0179, NNP1L, Nnp1, PPP1R136, RRP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006843 23077 MYCBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23077 "Myc-bp2, PAM, Phr " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006844 23077 MYCBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23077 "Myc-bp2, PAM, Phr " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006845 230784 Sesn2 http://www.ncbi.nlm.nih.gov/gene/?term=230784 "HI95, SEST2, Ses2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006846 23078 VWA8 http://www.ncbi.nlm.nih.gov/gene/?term=23078 KIAA0564 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006847 23078 VWA8 http://www.ncbi.nlm.nih.gov/gene/?term=23078 KIAA0564 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006848 230796 Wdtc1 http://www.ncbi.nlm.nih.gov/gene/?term=230796 "Gm695, adipose, adp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006849 23080 AVL9 http://www.ncbi.nlm.nih.gov/gene/?term=23080 KIAA0241 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006850 23081 KDM4C http://www.ncbi.nlm.nih.gov/gene/?term=23081 "GASC1, JHDM3C, JMJD2C, TDRD14C " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006851 23082 PPRC1 http://www.ncbi.nlm.nih.gov/gene/?term=23082 PRC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006852 23082 PPRC1 http://www.ncbi.nlm.nih.gov/gene/?term=23082 PRC mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006853 230868 Igsf21 http://www.ncbi.nlm.nih.gov/gene/?term=230868 "BC055811, Gm141 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006854 23086 EXPH5 http://www.ncbi.nlm.nih.gov/gene/?term=23086 "SLAC2-B, SLAC2B " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006855 23086 EXPH5 http://www.ncbi.nlm.nih.gov/gene/?term=23086 "SLAC2-B, SLAC2B " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006856 23087 TRIM35 http://www.ncbi.nlm.nih.gov/gene/?term=23087 "HLS5, MAIR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006857 23087 TRIM35 http://www.ncbi.nlm.nih.gov/gene/?term=23087 "HLS5, MAIR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006858 23087 TRIM35 http://www.ncbi.nlm.nih.gov/gene/?term=23087 "HLS5, MAIR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006859 230895 Vps13d http://www.ncbi.nlm.nih.gov/gene/?term=230895 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006860 23089 PEG10 http://www.ncbi.nlm.nih.gov/gene/?term=23089 "EDR, HB-1, MEF3L, Mar2, Mart2, RGAG3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006861 23089 PEG10 http://www.ncbi.nlm.nih.gov/gene/?term=23089 "EDR, HB-1, MEF3L, Mar2, Mart2, RGAG3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006862 2308 FOXO1 http://www.ncbi.nlm.nih.gov/gene/?term=2308 "FKH1, FKHR, FOXO1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006863 2308 FOXO1 http://www.ncbi.nlm.nih.gov/gene/?term=2308 "FKH1, FKHRA, FOXO1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006864 230903 Fbxo44 http://www.ncbi.nlm.nih.gov/gene/?term=230903 "5730411K09, AV001623, FBG3, FBX30, Fbx6a, Fbxo6a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006865 230903 Fbxo44 http://www.ncbi.nlm.nih.gov/gene/?term=230903 "5730411K09, AV001623, FBG3, FBX30, Fbx6a, Fbxo6a " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006866 23091 ZC3H13 http://www.ncbi.nlm.nih.gov/gene/?term=23091 KIAA0853 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006867 23092 ARHGAP26 http://www.ncbi.nlm.nih.gov/gene/?term=23092 "GRAF, GRAF1, OPHN1L, OPHN1L1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006868 23092 ARHGAP26 http://www.ncbi.nlm.nih.gov/gene/?term=23092 "GRAF, GRAF1, OPHN1L, OPHN1L1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006869 23093 TTLL5 http://www.ncbi.nlm.nih.gov/gene/?term=23093 "CORD19, KIAA0998, STAMP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006870 23093 TTLL5 http://www.ncbi.nlm.nih.gov/gene/?term=23093 "CORD19, KIAA0998, STAMP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006871 23094 SIPA1L3 http://www.ncbi.nlm.nih.gov/gene/?term=23094 "CTRCT45, SPAL3, SPAR3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006872 230959 Ajap1 http://www.ncbi.nlm.nih.gov/gene/?term=230959 Gm573 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006873 23095 KIF1B http://www.ncbi.nlm.nih.gov/gene/?term=23095 "CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006874 23095 KIF1B http://www.ncbi.nlm.nih.gov/gene/?term=23095 "CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006875 23097 CDK19 http://www.ncbi.nlm.nih.gov/gene/?term=23097 "CDC2L6, CDK11, bA346C16.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006876 23099 ZBTB43 http://www.ncbi.nlm.nih.gov/gene/?term=23099 "ZBTB22B, ZNF-X, ZNF297B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006877 2309 FOXO3 http://www.ncbi.nlm.nih.gov/gene/?term=2309 "AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006878 2309 FOXO3 http://www.ncbi.nlm.nih.gov/gene/?term=2309 "AF6q21, FKHRL1, FKHRL1P2, FOXO2A, FOXO3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006879 230 ALDOC http://www.ncbi.nlm.nih.gov/gene/?term=230 ALDC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006880 230 ALDOC http://www.ncbi.nlm.nih.gov/gene/?term=230 ALDC mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006881 230 ALDOC http://www.ncbi.nlm.nih.gov/gene/?term=230 ALDC mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00006882 23101 MCF2L2 http://www.ncbi.nlm.nih.gov/gene/?term=23101 ARHGEF22 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006883 23101 MCF2L2 http://www.ncbi.nlm.nih.gov/gene/?term=23101 ARHGEF22 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006884 231050 Galnt11 http://www.ncbi.nlm.nih.gov/gene/?term=231050 "A430075I06Rik, AI648252, E430002F06Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006885 231051 Kmt2c http://www.ncbi.nlm.nih.gov/gene/?term=231051 "E330008K23Rik, HALR, Mll3, mKIAA1506 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006886 231051 Kmt2c http://www.ncbi.nlm.nih.gov/gene/?term=231051 "E330008K23Rik, HALR, Mll3, mKIAA1506 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006887 23107 MRPS27 http://www.ncbi.nlm.nih.gov/gene/?term=23107 "MRP-S27, S27mt " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006888 23107 MRPS27 http://www.ncbi.nlm.nih.gov/gene/?term=23107 "MRP-S27, S27mt " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006889 23107 MRPS27 http://www.ncbi.nlm.nih.gov/gene/?term=23107 "MRP-S27, S27mt " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006890 23107 MRPS27 http://www.ncbi.nlm.nih.gov/gene/?term=23107 "MRP-S27, S27mt " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006891 231086 Hadhb http://www.ncbi.nlm.nih.gov/gene/?term=231086 "4930479F15Rik, Mtpb, TP-beta " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006892 23108 RAP1GAP2 http://www.ncbi.nlm.nih.gov/gene/?term=23108 "GARNL4, RAP1GA3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006893 23111 SPG20 http://www.ncbi.nlm.nih.gov/gene/?term=23111 "SPARTIN, TAHCCP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006894 23112 TNRC6B http://www.ncbi.nlm.nih.gov/gene/?term=23112 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006895 23112 TNRC6B http://www.ncbi.nlm.nih.gov/gene/?term=23112 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006896 23112 TNRC6B http://www.ncbi.nlm.nih.gov/gene/?term=23112 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006897 23116 FAM179B http://www.ncbi.nlm.nih.gov/gene/?term=23116 KIAA0423 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006898 23117 NPIPB3 http://www.ncbi.nlm.nih.gov/gene/?term=23117 "KIAA0220L, NPIP, NPIPB, NPIPB5, NPIPL3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006899 23118 TAB2 http://www.ncbi.nlm.nih.gov/gene/?term=23118 "CHTD2, MAP3K7IP2, TAB-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006900 23118 TAB2 http://www.ncbi.nlm.nih.gov/gene/?term=23118 "CHTD2, MAP3K7IP2, TAB-2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006901 23120 ATP10B http://www.ncbi.nlm.nih.gov/gene/?term=23120 ATPVB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006902 23122 CLASP2 http://www.ncbi.nlm.nih.gov/gene/?term=23122 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006903 23122 CLASP2 http://www.ncbi.nlm.nih.gov/gene/?term=23122 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006904 23122 CLASP2 http://www.ncbi.nlm.nih.gov/gene/?term=23122 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006905 231238 Sel1l3 http://www.ncbi.nlm.nih.gov/gene/?term=231238 "2310045A20Rik, AI429585, mKIAA0746 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006906 231252 Chrna9 http://www.ncbi.nlm.nih.gov/gene/?term=231252 "2410015I05Rik, Acra9, EG666827, Gm8311 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006907 23125 CAMTA2 http://www.ncbi.nlm.nih.gov/gene/?term=23125 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006908 23127 COLGALT2 http://www.ncbi.nlm.nih.gov/gene/?term=23127 "C1orf17, GLT25D2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006909 23129 PLXND1 http://www.ncbi.nlm.nih.gov/gene/?term=23129 PLEXD1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006910 23130 ATG2A http://www.ncbi.nlm.nih.gov/gene/?term=23130 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006911 23131 GPATCH8 http://www.ncbi.nlm.nih.gov/gene/?term=23131 "GPATC8, KIAA0553 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006912 23131 GPATCH8 http://www.ncbi.nlm.nih.gov/gene/?term=23131 "GPATC8, KIAA0553 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006913 23131 GPATCH8 http://www.ncbi.nlm.nih.gov/gene/?term=23131 "GPATC8, KIAA0553 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006914 231326 Aasdh http://www.ncbi.nlm.nih.gov/gene/?term=231326 "A230062G08Rik, A830035E16, Acsf4, U26 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006915 231329 Polr2b http://www.ncbi.nlm.nih.gov/gene/?term=231329 "Pol2rb, Rpb140, Rpb2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006916 23133 PHF8 http://www.ncbi.nlm.nih.gov/gene/?term=23133 "JHDM1F, MRXSSD, ZNF422 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006917 23135 KDM6B http://www.ncbi.nlm.nih.gov/gene/?term=23135 JMJD3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006918 23137 SMC5 http://www.ncbi.nlm.nih.gov/gene/?term=23137 SMC5L1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006919 23137 SMC5 http://www.ncbi.nlm.nih.gov/gene/?term=23137 SMC5L1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006920 23137 SMC5 http://www.ncbi.nlm.nih.gov/gene/?term=23137 SMC5L1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006921 231380 Uba6 http://www.ncbi.nlm.nih.gov/gene/?term=231380 "4930542H01, 5730469D23Rik, AU021846, AW124799, E1-L2, Ube1l2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006922 231386 Ythdc1 http://www.ncbi.nlm.nih.gov/gene/?term=231386 "A730098D12Rik, C80342, mKIAA1966 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006923 231386 Ythdc1 http://www.ncbi.nlm.nih.gov/gene/?term=231386 "A730098D12Rik, C80342, mKIAA1966 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006924 23139 MAST2 http://www.ncbi.nlm.nih.gov/gene/?term=23139 "MAST205, MTSSK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006925 2313 FLI1 http://www.ncbi.nlm.nih.gov/gene/?term=2313 "EWSR2, SIC-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006926 23140 ZZEF1 http://www.ncbi.nlm.nih.gov/gene/?term=23140 ZZZ4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006927 23140 ZZEF1 http://www.ncbi.nlm.nih.gov/gene/?term=23140 ZZZ4 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006928 23140 ZZEF1 http://www.ncbi.nlm.nih.gov/gene/?term=23140 ZZZ4 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006929 231413 Grsf1 http://www.ncbi.nlm.nih.gov/gene/?term=231413 "BB232551, C80280, D5Wsu31e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006930 23141 ANKLE2 http://www.ncbi.nlm.nih.gov/gene/?term=23141 "KIAA0692, LEMD7, Lem4, MCPH16 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006931 23142 DCUN1D4 http://www.ncbi.nlm.nih.gov/gene/?term=23142 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006932 23143 LRCH1 http://www.ncbi.nlm.nih.gov/gene/?term=23143 "CHDC1, NP81 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006933 231452 Sdad1 http://www.ncbi.nlm.nih.gov/gene/?term=231452 "4931421J16, AA591032, AW538460 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006934 231474 Paqr3 http://www.ncbi.nlm.nih.gov/gene/?term=231474 "6330415A20Rik, AY424292, RKTG " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006935 23149 FCHO1 http://www.ncbi.nlm.nih.gov/gene/?term=23149 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006936 2314 FLII http://www.ncbi.nlm.nih.gov/gene/?term=2314 "FLI, FLIL, Fli1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006937 2314 FLII http://www.ncbi.nlm.nih.gov/gene/?term=2314 "FLI, FLIL, Fli1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006938 2314 FLII http://www.ncbi.nlm.nih.gov/gene/?term=2314 "FLI, FLIL, Fli1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006939 231503 Tmem150c http://www.ncbi.nlm.nih.gov/gene/?term=231503 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006940 23151 GRAMD4 http://www.ncbi.nlm.nih.gov/gene/?term=23151 "DIP, dA59H18.1, dJ439F8.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006941 23152 CIC http://www.ncbi.nlm.nih.gov/gene/?term=23152 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006942 23154 NCDN http://www.ncbi.nlm.nih.gov/gene/?term=23154 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006943 23155 CLCC1 http://www.ncbi.nlm.nih.gov/gene/?term=23155 MCLC mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006944 23155 CLCC1 http://www.ncbi.nlm.nih.gov/gene/?term=23155 MCLC mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006945 23155 CLCC1 http://www.ncbi.nlm.nih.gov/gene/?term=23155 MCLC mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006946 2315 MLANA http://www.ncbi.nlm.nih.gov/gene/?term=2315 "MART-1, MART1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006947 231600 Chfr http://www.ncbi.nlm.nih.gov/gene/?term=231600 "5730484M20Rik, C230082M18, RNF116 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006948 23160 WDR43 http://www.ncbi.nlm.nih.gov/gene/?term=23160 "NET12, UTP5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006949 23161 SNX13 http://www.ncbi.nlm.nih.gov/gene/?term=23161 RGS-PX1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006950 231637 Ssh1 http://www.ncbi.nlm.nih.gov/gene/?term=231637 "AW551225, Gm1394, Gm1395, SSH-1, mSSH-1L " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006951 231637 Ssh1 http://www.ncbi.nlm.nih.gov/gene/?term=231637 "AW551225, Gm1394, Gm1395, SSH-1, mSSH-1L " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006952 23163 GGA3 http://www.ncbi.nlm.nih.gov/gene/?term=23163 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006953 231646 Myo1h http://www.ncbi.nlm.nih.gov/gene/?term=231646 4631401O15Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006954 23164 MPRIP http://www.ncbi.nlm.nih.gov/gene/?term=23164 "M-RIP, MRIP, RHOIP3, RIP3, p116Rip " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006955 23164 MPRIP http://www.ncbi.nlm.nih.gov/gene/?term=23164 "M-RIP, MRIP, RHOIP3, RIP3, p116Rip " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006956 23164 MPRIP http://www.ncbi.nlm.nih.gov/gene/?term=23164 "M-RIP, MRIP, RHOIP3, RIP3, p116Rip " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006957 231659 Gcn1l1 http://www.ncbi.nlm.nih.gov/gene/?term=231659 "4932409G22, AL022764, G431004K08Rik, GCN1L, Gcn1, mKIAA0219 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006958 23165 NUP205 http://www.ncbi.nlm.nih.gov/gene/?term=23165 C7orf14 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006959 23165 NUP205 http://www.ncbi.nlm.nih.gov/gene/?term=23165 "C7orf14, NPHS13 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006960 231670 Fbxo21 http://www.ncbi.nlm.nih.gov/gene/?term=231670 "2810425J22Rik, AU016673, mKIAA0875 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006961 231672 Fbxw8 http://www.ncbi.nlm.nih.gov/gene/?term=231672 "4930438M06Rik, FBW6, FBW8, FBXO29, Fbx29 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006962 23167 EFR3A http://www.ncbi.nlm.nih.gov/gene/?term=23167 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006963 23167 EFR3A http://www.ncbi.nlm.nih.gov/gene/?term=23167 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006964 23168 RTF1 http://www.ncbi.nlm.nih.gov/gene/?term=23168 "GTL7, KIAA0252 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006965 23168 RTF1 http://www.ncbi.nlm.nih.gov/gene/?term=23168 "GTL7, KIAA0252 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006966 23169 SLC35D1 http://www.ncbi.nlm.nih.gov/gene/?term=23169 UGTREL7 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006967 23169 SLC35D1 http://www.ncbi.nlm.nih.gov/gene/?term=23169 UGTREL7 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006968 23169 SLC35D1 http://www.ncbi.nlm.nih.gov/gene/?term=23169 UGTREL7 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006969 2316 FLNA http://www.ncbi.nlm.nih.gov/gene/?term=2316 "ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006970 2316 FLNA http://www.ncbi.nlm.nih.gov/gene/?term=2316 "ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006971 2316 FLNA http://www.ncbi.nlm.nih.gov/gene/?term=2316 "ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006972 23170 TTLL12 http://www.ncbi.nlm.nih.gov/gene/?term=23170 dJ526I14.2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006973 23170 TTLL12 http://www.ncbi.nlm.nih.gov/gene/?term=23170 dJ526I14.2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006974 231713 Naa25 http://www.ncbi.nlm.nih.gov/gene/?term=231713 "4833422K13Rik, A630046C11, AI450868, C330023M02Rik, Mdm20 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006975 231717 Fam109a http://www.ncbi.nlm.nih.gov/gene/?term=231717 "A230106M15Rik, AU017694, IPIP27A, Ses1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006976 23171 GPD1L http://www.ncbi.nlm.nih.gov/gene/?term=23171 GPD1-L mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006977 23171 GPD1L http://www.ncbi.nlm.nih.gov/gene/?term=23171 GPD1-L mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006978 23171 GPD1L http://www.ncbi.nlm.nih.gov/gene/?term=23171 GPD1-L mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006979 23172 FAM175B http://www.ncbi.nlm.nih.gov/gene/?term=23172 "ABRO1, KIAA0157 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006980 23173 METAP1 http://www.ncbi.nlm.nih.gov/gene/?term=23173 "MAP1A, MetAP1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006981 23173 METAP1 http://www.ncbi.nlm.nih.gov/gene/?term=23173 "MAP1A, MetAP1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006982 23173 METAP1 http://www.ncbi.nlm.nih.gov/gene/?term=23173 "MAP1A, MetAP1A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00006983 23174 ZCCHC14 http://www.ncbi.nlm.nih.gov/gene/?term=23174 "BDG-29, BDG29 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006984 23175 LPIN1 http://www.ncbi.nlm.nih.gov/gene/?term=23175 PAP1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006985 23175 LPIN1 http://www.ncbi.nlm.nih.gov/gene/?term=23175 PAP1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006986 231769 Sfswap http://www.ncbi.nlm.nih.gov/gene/?term=231769 "1190005N23Rik, 6330437E22Rik, AI197402, AW212079, SWAP, Sfrs8, Srsf8 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006987 23176 SEPT8 http://www.ncbi.nlm.nih.gov/gene/?term=23176 42615 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006988 23177 CEP68 http://www.ncbi.nlm.nih.gov/gene/?term=23177 KIAA0582 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006989 23177 CEP68 http://www.ncbi.nlm.nih.gov/gene/?term=23177 KIAA0582 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006990 23177 CEP68 http://www.ncbi.nlm.nih.gov/gene/?term=23177 KIAA0582 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006991 2317 FLNB http://www.ncbi.nlm.nih.gov/gene/?term=2317 "ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006992 2317 FLNB http://www.ncbi.nlm.nih.gov/gene/?term=2317 "ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00006993 231801 Agfg2 http://www.ncbi.nlm.nih.gov/gene/?term=231801 "A630095P14Rik, Hrbl, RAB-R, RABR " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00006994 231805 Pilra http://www.ncbi.nlm.nih.gov/gene/?term=231805 "AV021745, FDF03 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006995 23181 DIP2A http://www.ncbi.nlm.nih.gov/gene/?term=23181 "C21orf106, DIP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00006996 23181 DIP2A http://www.ncbi.nlm.nih.gov/gene/?term=23181 "C21orf106, DIP2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006997 23181 DIP2A http://www.ncbi.nlm.nih.gov/gene/?term=23181 "C21orf106, DIP2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00006998 231821 Adap1 http://www.ncbi.nlm.nih.gov/gene/?term=231821 "4930431P11Rik, Centa1, GC1L, p42IP4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00006999 231830 Micall2 http://www.ncbi.nlm.nih.gov/gene/?term=231830 "A930021H16Rik, JRAB, MICAL-L2, mFLJ00139 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007000 231842 Amz1 http://www.ncbi.nlm.nih.gov/gene/?term=231842 "5330426I05, 6530401C20Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007001 23184 MESDC2 http://www.ncbi.nlm.nih.gov/gene/?term=23184 "BOCA, MESD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007002 23184 MESDC2 http://www.ncbi.nlm.nih.gov/gene/?term=23184 "BOCA, MESD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007003 23185 LARP4B http://www.ncbi.nlm.nih.gov/gene/?term=23185 "KIAA0217, LARP5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007004 23185 LARP4B http://www.ncbi.nlm.nih.gov/gene/?term=23185 "KIAA0217, LARP5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007005 231866 Zfp12 http://www.ncbi.nlm.nih.gov/gene/?term=231866 "C530015C18, Krox-7, Zfp-12, Znf12 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007006 231868 E130309D02Rik http://www.ncbi.nlm.nih.gov/gene/?term=231868 A630028N22 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007007 23186 RCOR1 http://www.ncbi.nlm.nih.gov/gene/?term=23186 "COREST, RCOR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007008 231874 Ccz1 http://www.ncbi.nlm.nih.gov/gene/?term=231874 AU022870 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007009 23187 PHLDB1 http://www.ncbi.nlm.nih.gov/gene/?term=23187 LL5A mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007010 231887 Pdap1 http://www.ncbi.nlm.nih.gov/gene/?term=231887 "HASPP28, PAP, PAP1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007011 231889 Bud31 http://www.ncbi.nlm.nih.gov/gene/?term=231889 "C77604, EDG-2, EDG2, G10 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007012 23189 KANK1 http://www.ncbi.nlm.nih.gov/gene/?term=23189 "ANKRD15, CPSQ2, KANK " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007013 23190 UBXN4 http://www.ncbi.nlm.nih.gov/gene/?term=23190 "UBXD2, UBXDC1, erasin " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007014 23190 UBXN4 http://www.ncbi.nlm.nih.gov/gene/?term=23190 "UBXD2, UBXDC1, erasin " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007015 23190 UBXN4 http://www.ncbi.nlm.nih.gov/gene/?term=23190 "UBXD2, UBXDC1, erasin " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007016 23190 UBXN4 http://www.ncbi.nlm.nih.gov/gene/?term=23190 "UBXD2, UBXDC1, erasin " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007017 23191 CYFIP1 http://www.ncbi.nlm.nih.gov/gene/?term=23191 "P140SRA-1, SHYC, SRA-1, SRA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007018 23191 CYFIP1 http://www.ncbi.nlm.nih.gov/gene/?term=23191 "P140SRA-1, SHYC, SRA-1, SRA1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007019 23192 ATG4B http://www.ncbi.nlm.nih.gov/gene/?term=23192 "APG4B, AUTL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007020 231931 Gimap6 http://www.ncbi.nlm.nih.gov/gene/?term=231931 "4833419H03Rik, Ian6, mFLJ00102 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007021 23193 GANAB http://www.ncbi.nlm.nih.gov/gene/?term=23193 "G2AN, GIIA, GLUII " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007022 23195 MDN1 http://www.ncbi.nlm.nih.gov/gene/?term=23195 Rea1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007023 23195 MDN1 http://www.ncbi.nlm.nih.gov/gene/?term=23195 Rea1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007024 23196 FAM120A http://www.ncbi.nlm.nih.gov/gene/?term=23196 "C9orf10, DNAPTP1, DNAPTP5, OSSA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007025 23196 FAM120A http://www.ncbi.nlm.nih.gov/gene/?term=23196 "C9orf10, DNAPTP1, DNAPTP5, OSSA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007026 23196 FAM120A http://www.ncbi.nlm.nih.gov/gene/?term=23196 "C9orf10, DNAPTP1, DNAPTP5, OSSA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007027 23197 FAF2 http://www.ncbi.nlm.nih.gov/gene/?term=23197 "ETEA, UBXD8, UBXN3B " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007028 23197 FAF2 http://www.ncbi.nlm.nih.gov/gene/?term=23197 "ETEA, UBXD8, UBXN3B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007029 231986 Jazf1 http://www.ncbi.nlm.nih.gov/gene/?term=231986 "AI591476, C820002C15, Jaz1, Tip27 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007030 23198 PSME4 http://www.ncbi.nlm.nih.gov/gene/?term=23198 PA200 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007031 23198 PSME4 http://www.ncbi.nlm.nih.gov/gene/?term=23198 PA200 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007032 23199 GSE1 http://www.ncbi.nlm.nih.gov/gene/?term=23199 KIAA0182 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007033 2319 FLOT2 http://www.ncbi.nlm.nih.gov/gene/?term=2319 "ECS-1, ECS1, ESA, ESA1, M17S1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007034 2319 FLOT2 http://www.ncbi.nlm.nih.gov/gene/?term=2319 "ECS-1, ECS1, ESA, ESA1, M17S1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007035 231 AKR1B1 http://www.ncbi.nlm.nih.gov/gene/?term=231 "ADR, ALDR1, ALR2, AR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007036 23200 ATP11B http://www.ncbi.nlm.nih.gov/gene/?term=23200 "ATPIF, ATPIR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007037 23200 ATP11B http://www.ncbi.nlm.nih.gov/gene/?term=23200 "ATPIF, ATPIR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007038 23203 PMPCA http://www.ncbi.nlm.nih.gov/gene/?term=23203 "Alpha-MPP, INPP5E, P-55, SCAR2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007039 23203 PMPCA http://www.ncbi.nlm.nih.gov/gene/?term=23203 "Alpha-MPP, INPP5E, P-55, SCAR2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007040 23204 ARL6IP1 http://www.ncbi.nlm.nih.gov/gene/?term=23204 "AIP1, ARL6IP, ARMER, SPG61 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007041 23204 ARL6IP1 http://www.ncbi.nlm.nih.gov/gene/?term=23204 "AIP1, ARL6IP, ARMER, SPG61 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007042 232087 Mat2a http://www.ncbi.nlm.nih.gov/gene/?term=232087 D630045P18Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007043 23208 SYT11 http://www.ncbi.nlm.nih.gov/gene/?term=23208 "SYT12, sytXI " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007044 23208 SYT11 http://www.ncbi.nlm.nih.gov/gene/?term=23208 "SYT12, sytXI " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007045 23210 JMJD6 http://www.ncbi.nlm.nih.gov/gene/?term=23210 "PSR, PTDSR, PTDSR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007046 23211 ZC3H4 http://www.ncbi.nlm.nih.gov/gene/?term=23211 C19orf7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007047 23214 XPO6 http://www.ncbi.nlm.nih.gov/gene/?term=23214 "EXP6, RANBP20 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007048 23214 XPO6 http://www.ncbi.nlm.nih.gov/gene/?term=23214 "EXP6, RANBP20 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007049 232157 Mob1a http://www.ncbi.nlm.nih.gov/gene/?term=232157 "4022402H07Rik, MOB1, MOB4B, Mobk1b, Mobkl1b " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007050 23215 PRRC2C http://www.ncbi.nlm.nih.gov/gene/?term=23215 "BAT2-iso, BAT2D1, BAT2L2, XTP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007051 23215 PRRC2C http://www.ncbi.nlm.nih.gov/gene/?term=23215 "BAT2-iso, BAT2D1, BAT2L2, XTP2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007052 232187 Smyd5 http://www.ncbi.nlm.nih.gov/gene/?term=232187 "AW536703, NN8-4AG, Rai15, Rrg1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007053 23218 NBEAL2 http://www.ncbi.nlm.nih.gov/gene/?term=23218 "BDPLT4, GPS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007054 232196 C87436 http://www.ncbi.nlm.nih.gov/gene/?term=232196 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007055 23219 FBXO28 http://www.ncbi.nlm.nih.gov/gene/?term=23219 "CENP-30, Fbx28 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007056 23219 FBXO28 http://www.ncbi.nlm.nih.gov/gene/?term=23219 "CENP-30, Fbx28 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007057 2321 FLT1 http://www.ncbi.nlm.nih.gov/gene/?term=2321 "FLT, FLT-1, VEGFR-1, VEGFR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007058 23220 DTX4 http://www.ncbi.nlm.nih.gov/gene/?term=23220 RNF155 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007059 23220 DTX4 http://www.ncbi.nlm.nih.gov/gene/?term=23220 RNF155 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007060 232236 Ccdc174 http://www.ncbi.nlm.nih.gov/gene/?term=232236 C130022K22Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007061 23224 SYNE2 http://www.ncbi.nlm.nih.gov/gene/?term=23224 "EDMD5, NUA, NUANCE, Nesp2, Nesprin-2, SYNE-2, TROPH " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007062 23224 SYNE2 http://www.ncbi.nlm.nih.gov/gene/?term=23224 "EDMD5, NUA, NUANCE, Nesp2, Nesprin-2, SYNE-2, TROPH " mRNA Homo sapiens 26272916 Endoplasmic reticulum U2OS cell Fluorescence in situ hybridization "Next, we monitored the localization of nesprin-2 (SYNE2) mRNA, which encodes a giant tail-anchored protein (796 kDa) that is present on the outer nuclear envelope and is involved in nuclear positioning (Luxton et al., 2010). After extraction, about two thirds of the foci remained, indicating that some of this mRNA was anchored to the ER (Fig. 1A,B). To ensure that the FISH signal was specific, we also probed cells that were depleted of the endogenous nesprin-2 mRNA using RNA interference (RNAi). Indeed, small hairpin RNA (shRNA)-treated cells lost 90% of their signal (supplementary material Fig. S1), indicating that our nesprin-2 probes detected the intended target. Like Sec61b, nesprin-2 mRNA largely remained associated with the ER in cells treated with HHT, or puromycin and EDTA. Thus nesprin-2, like Sec61b, can associate with the ER membrane, and this activity is mostly independent of translation. " RLID00007063 23225 NUP210 http://www.ncbi.nlm.nih.gov/gene/?term=23225 "GP210, POM210 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007064 23225 NUP210 http://www.ncbi.nlm.nih.gov/gene/?term=23225 "GP210, POM210 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007065 23225 NUP210 http://www.ncbi.nlm.nih.gov/gene/?term=23225 "GP210, POM210 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007066 232286 Tmf1 http://www.ncbi.nlm.nih.gov/gene/?term=232286 "7030402D04Rik, Gm153`, Tmf1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007067 23230 VPS13A http://www.ncbi.nlm.nih.gov/gene/?term=23230 "CHAC, CHOREIN " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007068 23231 SEL1L3 http://www.ncbi.nlm.nih.gov/gene/?term=23231 Sel-1L3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007069 232339 Ankrd26 http://www.ncbi.nlm.nih.gov/gene/?term=232339 "5730521P14Rik, BC008111, mKIAA1074 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007070 232341 Wnk1 http://www.ncbi.nlm.nih.gov/gene/?term=232341 "6430573H23Rik, EG406236, Hsn2, Prkwnk1, mKIAA0344 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007071 232341 Wnk1 http://www.ncbi.nlm.nih.gov/gene/?term=232341 "6430573H23Rik, EG406236, Hsn2, Prkwnk1, mKIAA0344 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007072 23234 DNAJC9 http://www.ncbi.nlm.nih.gov/gene/?term=23234 "HDJC9, JDD1, SB73 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007073 23235 SIK2 http://www.ncbi.nlm.nih.gov/gene/?term=23235 "LOH11CR1I, QIK, SIK-2, SNF1LK2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007074 23237 ARC http://www.ncbi.nlm.nih.gov/gene/?term=23237 Arg3.1 mRNA Homo sapiens 11466419 Dendrite NIH3T3 cell|Neuro2a cell In situ hybridization|Northern blot "More recently, arg3.1/arc became of interest, because after synaptic stimulation, arg3.1/arc mRNA is rapidly induced and distributed to dendritic processes and may be locally translated there to facilitate synapse-specific modifications. " RLID00007075 23239 PHLPP1 http://www.ncbi.nlm.nih.gov/gene/?term=23239 "PHLPP, PLEKHE1, PPM3A, SCOP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007076 23239 PHLPP1 http://www.ncbi.nlm.nih.gov/gene/?term=23239 "PHLPP, PLEKHE1, PPM3A, SCOP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007077 2323 FLT3LG http://www.ncbi.nlm.nih.gov/gene/?term=2323 "FL, FLT3L " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007078 232409 Clec2e http://www.ncbi.nlm.nih.gov/gene/?term=232409 "Clra, clr-a " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007079 23241 PACS2 http://www.ncbi.nlm.nih.gov/gene/?term=23241 "PACS-2, PACS1L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007080 23241 PACS2 http://www.ncbi.nlm.nih.gov/gene/?term=23241 "PACS-2, PACS1L " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007081 23241 PACS2 http://www.ncbi.nlm.nih.gov/gene/?term=23241 "PACS-2, PACS1L " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007082 23243 ANKRD28 http://www.ncbi.nlm.nih.gov/gene/?term=23243 "PITK, PPP1R65 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007083 23243 ANKRD28 http://www.ncbi.nlm.nih.gov/gene/?term=23243 "PITK, PPP1R65 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007084 23244 PDS5A http://www.ncbi.nlm.nih.gov/gene/?term=23244 "PIG54, SCC-112, SCC112 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007085 23244 PDS5A http://www.ncbi.nlm.nih.gov/gene/?term=23244 "PIG54, SCC-112, SCC112 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007086 23248 RPRD2 http://www.ncbi.nlm.nih.gov/gene/?term=23248 "HSPC099, KIAA0460 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007087 23250 ATP11A http://www.ncbi.nlm.nih.gov/gene/?term=23250 "ATPIH, ATPIS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007088 23250 ATP11A http://www.ncbi.nlm.nih.gov/gene/?term=23250 "ATPIH, ATPIS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007089 23252 OTUD3 http://www.ncbi.nlm.nih.gov/gene/?term=23252 DUBA4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007090 23252 OTUD3 http://www.ncbi.nlm.nih.gov/gene/?term=23252 DUBA4 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007091 23252 OTUD3 http://www.ncbi.nlm.nih.gov/gene/?term=23252 DUBA4 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007092 23253 ANKRD12 http://www.ncbi.nlm.nih.gov/gene/?term=23253 "ANCO-2, ANCO1, GAC-1, Nbla00144 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007093 23253 ANKRD12 http://www.ncbi.nlm.nih.gov/gene/?term=23253 "ANCO-2, ANCO1, GAC-1, Nbla00144 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007094 23253 ANKRD12 http://www.ncbi.nlm.nih.gov/gene/?term=23253 "ANCO-2, ANCO1, GAC-1, Nbla00144 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007095 232560 Caprin2 http://www.ncbi.nlm.nih.gov/gene/?term=232560 "C1qdc1, Eeg1, rng140 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007096 232566 Amn1 http://www.ncbi.nlm.nih.gov/gene/?term=232566 "5830467E07Rik, A230083D09, C730024G19Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007097 232566 Amn1 http://www.ncbi.nlm.nih.gov/gene/?term=232566 "5830467E07Rik, A230083D09, C730024G19Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007098 23256 SCFD1 http://www.ncbi.nlm.nih.gov/gene/?term=23256 "C14orf163, RA410, SLY1, SLY1P, STXBP1L2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007099 23256 SCFD1 http://www.ncbi.nlm.nih.gov/gene/?term=23256 "C14orf163, RA410, SLY1, SLY1P, STXBP1L2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007100 23258 DENND5A http://www.ncbi.nlm.nih.gov/gene/?term=23258 RAB6IP1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007101 232599 Gm4876 http://www.ncbi.nlm.nih.gov/gene/?term=232599 "B930018B01, EG232599 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007102 23261 CAMTA1 http://www.ncbi.nlm.nih.gov/gene/?term=23261 CANPMR mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007103 23261 CAMTA1 http://www.ncbi.nlm.nih.gov/gene/?term=23261 CANPMR mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007104 23261 CAMTA1 http://www.ncbi.nlm.nih.gov/gene/?term=23261 CANPMR mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007105 23262 PPIP5K2 http://www.ncbi.nlm.nih.gov/gene/?term=23262 "CFAP160, HISPPD1, IP7K2, VIP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007106 23262 PPIP5K2 http://www.ncbi.nlm.nih.gov/gene/?term=23262 "CFAP160, HISPPD1, IP7K2, VIP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007107 23263 MCF2L http://www.ncbi.nlm.nih.gov/gene/?term=23263 "ARHGEF14, DBS, OST " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007108 23263 MCF2L http://www.ncbi.nlm.nih.gov/gene/?term=23263 "ARHGEF14, DBS, OST " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007109 23264 ZC3H7B http://www.ncbi.nlm.nih.gov/gene/?term=23264 RoXaN mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007110 23265 EXOC7 http://www.ncbi.nlm.nih.gov/gene/?term=23265 "2-5-3p, EX070, EXO70, EXOC1, Exo70p, YJL085W " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007111 23265 EXOC7 http://www.ncbi.nlm.nih.gov/gene/?term=23265 "2-5-3p, EX070, EXO70, EXOC1, Exo70p, YJL085W " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007112 232680 Cpa2 http://www.ncbi.nlm.nih.gov/gene/?term=232680 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007113 232685 Lncpint http://www.ncbi.nlm.nih.gov/gene/?term=232685 "Lincpint, MNCb-1768, Pint, linc-Pint " lncRNA Mus musculus 24070194 Nucleus Lung tumor cell qRT-PCR "Pint is a nuclear lincRNA that directly interacts with the Polycomb repressive complex 2 (PRC2), and is required for PRC2 targeting of specific genes for H3K27 tri-methylation and repression. " RLID00007114 23268 DNMBP http://www.ncbi.nlm.nih.gov/gene/?term=23268 "ARHGEF36, TUBA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007115 23269 MGA http://www.ncbi.nlm.nih.gov/gene/?term=23269 "MAD5, MXD5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007116 23269 MGA http://www.ncbi.nlm.nih.gov/gene/?term=23269 "MAD5, MXD5 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007117 2326 FMO1 http://www.ncbi.nlm.nih.gov/gene/?term=2326 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007118 23270 TSPYL4 http://www.ncbi.nlm.nih.gov/gene/?term=23270 dJ486I3.2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007119 23272 FAM208A http://www.ncbi.nlm.nih.gov/gene/?term=23272 "C3orf63, RAP140, se89-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007120 23274 CLEC16A http://www.ncbi.nlm.nih.gov/gene/?term=23274 "Gop-1, KIAA0350 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007121 23275 POFUT2 http://www.ncbi.nlm.nih.gov/gene/?term=23275 "C21orf80, FUT13 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007122 23276 KLHL18 http://www.ncbi.nlm.nih.gov/gene/?term=23276 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007123 23276 KLHL18 http://www.ncbi.nlm.nih.gov/gene/?term=23276 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007124 23277 CLUH http://www.ncbi.nlm.nih.gov/gene/?term=23277 "CLU1, KIAA0664 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007125 232798 Leng8 http://www.ncbi.nlm.nih.gov/gene/?term=232798 AW049671 mRNA Mus musculus 22817891 Nucleus Bone marrow Macrophage Next-generation sequencing "Cluster 7, for example, contains abundant transcripts in the chromatin, with much lower transcript levels in the nucleoplasm and cytoplasm relative to the other clusters. This cluster is dominated by annotated and unannotated non-coding transcripts and miRNA precursors. (The analysis excluded transcripts shorter than 400 nucleotides and therefore excluded mature miRNAs and many miRNA precursors.) Some non-coding RNAs, such as Xist, are highly enriched in the chromatin because they function at this location (Figure S2). Examples of other non-coding RNAs in Cluster 7 are Neat1 and Malat1/Neat2 (Figure S2). Further mining of the data sets may provide insights into the subcellular locations at which many non-coding RNAs function. Cluster 7 also includes transcripts from constitutive protein-coding genes that may be highly unstable and therefore present at low levels in the cytoplasm (e.g. Leng8 in Figure S2). " RLID00007126 23279 NUP160 http://www.ncbi.nlm.nih.gov/gene/?term=23279 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007127 23279 NUP160 http://www.ncbi.nlm.nih.gov/gene/?term=23279 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007128 232801 Lilra5 http://www.ncbi.nlm.nih.gov/gene/?term=232801 "E030017K20, EG232801, Gm4878, Lilrc1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007129 232807 Ppp1r12c http://www.ncbi.nlm.nih.gov/gene/?term=232807 "2410197A17Rik, AI839747, B430101M08, Mbs85 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007130 232821 Ccdc106 http://www.ncbi.nlm.nih.gov/gene/?term=232821 BC018462 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007131 23283 CSTF2T http://www.ncbi.nlm.nih.gov/gene/?term=23283 CstF-64T mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007132 23286 WWC1 http://www.ncbi.nlm.nih.gov/gene/?term=23286 "HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007133 232875 Zscan18 http://www.ncbi.nlm.nih.gov/gene/?term=232875 EG232875 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007134 23287 AGTPBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23287 "CCP1, NNA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007135 23287 AGTPBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23287 "CCP1, NNA1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007136 23291 FBXW11 http://www.ncbi.nlm.nih.gov/gene/?term=23291 "BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007137 23291 FBXW11 http://www.ncbi.nlm.nih.gov/gene/?term=23291 "BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007138 232934 Mypop http://www.ncbi.nlm.nih.gov/gene/?term=232934 "Myodysa, P42pop " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007139 23293 SMG6 http://www.ncbi.nlm.nih.gov/gene/?term=23293 "C17orf31, EST1A, SMG-6, hSMG5/7a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007140 232943 Klc3 http://www.ncbi.nlm.nih.gov/gene/?term=232943 "BC017147, Klct " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007141 232947 Ppp1r37 http://www.ncbi.nlm.nih.gov/gene/?term=232947 "Gm158, Lrrc68 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007142 23294 ANKS1A http://www.ncbi.nlm.nih.gov/gene/?term=23294 ANKS1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007143 23294 ANKS1A http://www.ncbi.nlm.nih.gov/gene/?term=23294 ANKS1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007144 23295 MGRN1 http://www.ncbi.nlm.nih.gov/gene/?term=23295 RNF156 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007145 23295 MGRN1 http://www.ncbi.nlm.nih.gov/gene/?term=23295 RNF156 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007146 23295 MGRN1 http://www.ncbi.nlm.nih.gov/gene/?term=23295 RNF156 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007147 23295 MGRN1 http://www.ncbi.nlm.nih.gov/gene/?term=23295 RNF156 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007148 232969 Zfp428 http://www.ncbi.nlm.nih.gov/gene/?term=232969 "2410005H09Rik, AV271806, AW047854, Znf428 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007149 232987 B9d2 http://www.ncbi.nlm.nih.gov/gene/?term=232987 stumpy mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007150 232989 Hnrnpul1 http://www.ncbi.nlm.nih.gov/gene/?term=232989 "E130317O14Rik, E1B-AP5, E1BAP5, Hnrnpul, Hnrpul1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007151 23299 BICD2 http://www.ncbi.nlm.nih.gov/gene/?term=23299 "SMALED2, bA526D8.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007152 23300 ATMIN http://www.ncbi.nlm.nih.gov/gene/?term=23300 "ASCIZ, ZNF822 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007153 23300 ATMIN http://www.ncbi.nlm.nih.gov/gene/?term=23300 "ASCIZ, ZNF822 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007154 233016 Blvrb http://www.ncbi.nlm.nih.gov/gene/?term=233016 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007155 23303 KIF13B http://www.ncbi.nlm.nih.gov/gene/?term=23303 GAKIN mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007156 23304 UBR2 http://www.ncbi.nlm.nih.gov/gene/?term=23304 "C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007157 23304 UBR2 http://www.ncbi.nlm.nih.gov/gene/?term=23304 "C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007158 233056 Zfp790 http://www.ncbi.nlm.nih.gov/gene/?term=233056 6330581L23Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007159 233058 Zfp420 http://www.ncbi.nlm.nih.gov/gene/?term=233058 "B230119D13, B230312I18Rik, mszf59-1, mszf70 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007160 233065 Alkbh6 http://www.ncbi.nlm.nih.gov/gene/?term=233065 "AI839550, Abh6, C130099A02 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007161 23306 NEMP1 http://www.ncbi.nlm.nih.gov/gene/?term=23306 "TMEM194, TMEM194A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007162 23306 NEMP1 http://www.ncbi.nlm.nih.gov/gene/?term=23306 "TMEM194, TMEM194A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007163 233079 Ffar2 http://www.ncbi.nlm.nih.gov/gene/?term=233079 "GPCR43, Gpr43 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007164 23308 ICOSLG http://www.ncbi.nlm.nih.gov/gene/?term=23308 "B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007165 23309 SIN3B http://www.ncbi.nlm.nih.gov/gene/?term=23309 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007166 23309 SIN3B http://www.ncbi.nlm.nih.gov/gene/?term=23309 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007167 2330 FMO5 http://www.ncbi.nlm.nih.gov/gene/?term=2330 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007168 23310 NCAPD3 http://www.ncbi.nlm.nih.gov/gene/?term=23310 "CAP-D3, CAPD3, hCAP-D3, hHCP-6, hcp-6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007169 23313 KIAA0930 http://www.ncbi.nlm.nih.gov/gene/?term=23313 "C22orf9, LSC3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007170 23314 SATB2 http://www.ncbi.nlm.nih.gov/gene/?term=23314 GLSS mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007171 23317 DNAJC13 http://www.ncbi.nlm.nih.gov/gene/?term=23317 "PARK21, RME8 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007172 233189 Ctu1 http://www.ncbi.nlm.nih.gov/gene/?term=233189 "Atpbd3, BC005752 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007173 23318 ZCCHC11 http://www.ncbi.nlm.nih.gov/gene/?term=23318 "PAPD3, TUT4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007174 23318 ZCCHC11 http://www.ncbi.nlm.nih.gov/gene/?term=23318 "PAPD3, TUT4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007175 2331 FMOD http://www.ncbi.nlm.nih.gov/gene/?term=2331 "FM, SLRR2E " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007176 23321 TRIM2 http://www.ncbi.nlm.nih.gov/gene/?term=23321 "CMT2R, RNF86 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007177 23322 RPGRIP1L http://www.ncbi.nlm.nih.gov/gene/?term=23322 "CORS3, FTM, JBTS7, MKS5, NPHP8, PPP1R134 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007178 23322 RPGRIP1L http://www.ncbi.nlm.nih.gov/gene/?term=23322 "CORS3, FTM, JBTS7, MKS5, NPHP8, PPP1R134 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007179 23324 MAN2B2 http://www.ncbi.nlm.nih.gov/gene/?term=23324 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007180 23324 MAN2B2 http://www.ncbi.nlm.nih.gov/gene/?term=23324 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007181 23326 USP22 http://www.ncbi.nlm.nih.gov/gene/?term=23326 USP3L mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007182 23326 USP22 http://www.ncbi.nlm.nih.gov/gene/?term=23326 USP3L mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007183 23326 USP22 http://www.ncbi.nlm.nih.gov/gene/?term=23326 USP3L mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007184 233276 Tubgcp5 http://www.ncbi.nlm.nih.gov/gene/?term=233276 "B130010C12Rik, GCP5, mKIAA1899 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007185 23327 NEDD4L http://www.ncbi.nlm.nih.gov/gene/?term=23327 "NEDD4-2, NEDD4.2, RSP5, hNEDD4-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007186 23327 NEDD4L http://www.ncbi.nlm.nih.gov/gene/?term=23327 "NEDD4-2, NEDD4.2, RSP5, hNEDD4-2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007187 233280 Nipa1 http://www.ncbi.nlm.nih.gov/gene/?term=233280 "1110027G09Rik, A830014A18Rik, FSP3, Spg6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007188 23328 SASH1 http://www.ncbi.nlm.nih.gov/gene/?term=23328 "SH3D6A, dJ323M4, dJ323M4.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007189 23328 SASH1 http://www.ncbi.nlm.nih.gov/gene/?term=23328 "SH3D6A, dJ323M4, dJ323M4.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007190 23328 SASH1 http://www.ncbi.nlm.nih.gov/gene/?term=23328 "SH3D6A, dJ323M4, dJ323M4.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007191 2332 FMR1 http://www.ncbi.nlm.nih.gov/gene/?term=2332 "FMRP, FRAXA, POF, POF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007192 2332 FMR1 http://www.ncbi.nlm.nih.gov/gene/?term=2332 "FMRP, FRAXA, POF, POF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007193 2332 FMR1 http://www.ncbi.nlm.nih.gov/gene/?term=2332 "FMRP, FRAXA, POF, POF1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007194 23331 TTC28 http://www.ncbi.nlm.nih.gov/gene/?term=23331 TPRBK mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007195 23332 CLASP1 http://www.ncbi.nlm.nih.gov/gene/?term=23332 MAST1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007196 23333 DPY19L1 http://www.ncbi.nlm.nih.gov/gene/?term=23333 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007197 23333 DPY19L1 http://www.ncbi.nlm.nih.gov/gene/?term=23333 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007198 23334 SZT2 http://www.ncbi.nlm.nih.gov/gene/?term=23334 "C1orf84, EIEE18, KIAA0467, SZT2A, SZT2B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007199 23338 JADE2 http://www.ncbi.nlm.nih.gov/gene/?term=23338 "JADE-2, PHF15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007200 23338 JADE2 http://www.ncbi.nlm.nih.gov/gene/?term=23338 "JADE-2, PHF15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007201 23339 VPS39 http://www.ncbi.nlm.nih.gov/gene/?term=23339 "TLP, VAM6, hVam6p " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007202 23339 VPS39 http://www.ncbi.nlm.nih.gov/gene/?term=23339 "TLP, VAM6, hVam6p " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007203 23339 VPS39 http://www.ncbi.nlm.nih.gov/gene/?term=23339 "TLP, VAM6, hVam6p " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007204 23339 VPS39 http://www.ncbi.nlm.nih.gov/gene/?term=23339 "TLP, VAM6, hVam6p " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007205 23339 VPS39 http://www.ncbi.nlm.nih.gov/gene/?term=23339 "TLP, VAM6, hVam6p " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007206 233405 Vps33b http://www.ncbi.nlm.nih.gov/gene/?term=233405 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007207 233406 Prc1 http://www.ncbi.nlm.nih.gov/gene/?term=233406 D7Ertd348e mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007208 23341 DNAJC16 http://www.ncbi.nlm.nih.gov/gene/?term=23341 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007209 23344 ESYT1 http://www.ncbi.nlm.nih.gov/gene/?term=23344 "FAM62A, MBC2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007210 23344 ESYT1 http://www.ncbi.nlm.nih.gov/gene/?term=23344 "FAM62A, MBC2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007211 23347 SMCHD1 http://www.ncbi.nlm.nih.gov/gene/?term=23347 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007212 233489 Picalm http://www.ncbi.nlm.nih.gov/gene/?term=233489 "CALM, CLTH, PAP180, fit-1, fit1, mKIAA4114 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007213 23348 DOCK9 http://www.ncbi.nlm.nih.gov/gene/?term=23348 "ZIZ1, ZIZIMIN1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007214 23350 U2SURP http://www.ncbi.nlm.nih.gov/gene/?term=23350 "SR140, fSAPa " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007215 23350 U2SURP http://www.ncbi.nlm.nih.gov/gene/?term=23350 "SR140, fSAPa " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007216 23350 U2SURP http://www.ncbi.nlm.nih.gov/gene/?term=23350 "SR140, fSAPa " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007217 23351 KHNYN http://www.ncbi.nlm.nih.gov/gene/?term=23351 KIAA0323 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007218 23351 KHNYN http://www.ncbi.nlm.nih.gov/gene/?term=23351 KIAA0323 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007219 23352 UBR4 http://www.ncbi.nlm.nih.gov/gene/?term=23352 "RBAF600, ZUBR1, p600 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007220 23352 UBR4 http://www.ncbi.nlm.nih.gov/gene/?term=23352 "RBAF600, ZUBR1, p600 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007221 23352 UBR4 http://www.ncbi.nlm.nih.gov/gene/?term=23352 "RBAF600, ZUBR1, p600 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007222 23353 SUN1 http://www.ncbi.nlm.nih.gov/gene/?term=23353 UNC84A mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007223 23353 SUN1 http://www.ncbi.nlm.nih.gov/gene/?term=23353 UNC84A mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007224 23357 ANGEL1 http://www.ncbi.nlm.nih.gov/gene/?term=23357 "Ccr4e, KIAA0759 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007225 23357 ANGEL1 http://www.ncbi.nlm.nih.gov/gene/?term=23357 "Ccr4e, KIAA0759 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007226 23358 USP24 http://www.ncbi.nlm.nih.gov/gene/?term=23358 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007227 23358 USP24 http://www.ncbi.nlm.nih.gov/gene/?term=23358 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007228 23359 FAM189A1 http://www.ncbi.nlm.nih.gov/gene/?term=23359 TMEM228 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007229 2335 FN1 http://www.ncbi.nlm.nih.gov/gene/?term=2335 "CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007230 2335 FN1 http://www.ncbi.nlm.nih.gov/gene/?term=2335 "CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007231 23360 FNBP4 http://www.ncbi.nlm.nih.gov/gene/?term=23360 FBP30 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007232 23361 ZNF629 http://www.ncbi.nlm.nih.gov/gene/?term=23361 "ZNF, ZNF65 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007233 23362 PSD3 http://www.ncbi.nlm.nih.gov/gene/?term=23362 "EFA6D, EFA6R, HCA67 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007234 23362 PSD3 http://www.ncbi.nlm.nih.gov/gene/?term=23362 "EFA6D, EFA6R, HCA67 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007235 23363 OBSL1 http://www.ncbi.nlm.nih.gov/gene/?term=23363 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007236 23365 ARHGEF12 http://www.ncbi.nlm.nih.gov/gene/?term=23365 "LARG, PRO2792 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007237 23365 ARHGEF12 http://www.ncbi.nlm.nih.gov/gene/?term=23365 "LARG, PRO2792 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007238 23365 ARHGEF12 http://www.ncbi.nlm.nih.gov/gene/?term=23365 "LARG, PRO2792 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007239 23367 LARP1 http://www.ncbi.nlm.nih.gov/gene/?term=23367 LARP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007240 23367 LARP1 http://www.ncbi.nlm.nih.gov/gene/?term=23367 LARP mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007241 23369 PUM2 http://www.ncbi.nlm.nih.gov/gene/?term=23369 "PUMH2, PUML2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007242 23369 PUM2 http://www.ncbi.nlm.nih.gov/gene/?term=23369 "PUMH2, PUML2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007243 23369 PUM2 http://www.ncbi.nlm.nih.gov/gene/?term=23369 "PUMH2, PUML2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007244 23370 ARHGEF18 http://www.ncbi.nlm.nih.gov/gene/?term=23370 P114-RhoGEF mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007245 233726 Ipo7 http://www.ncbi.nlm.nih.gov/gene/?term=233726 "A330055O14Rik, C330016G14, Imp7, Ranbp7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007246 233733 Galnt18 http://www.ncbi.nlm.nih.gov/gene/?term=233733 "2900011G21Rik, BC024988, Galntl4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007247 23373 CRTC1 http://www.ncbi.nlm.nih.gov/gene/?term=23373 "MECT1, TORC-1, TORC1, WAMTP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007248 233744 Spon1 http://www.ncbi.nlm.nih.gov/gene/?term=233744 "AI666765, AW455831, BC020531, D330035F22Rik, FSP " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007249 23376 UFL1 http://www.ncbi.nlm.nih.gov/gene/?term=23376 "KIAA0776, Maxer, NLBP, RCAD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007250 23376 UFL1 http://www.ncbi.nlm.nih.gov/gene/?term=23376 "KIAA0776, Maxer, NLBP, RCAD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007251 23378 RRP8 http://www.ncbi.nlm.nih.gov/gene/?term=23378 "KIAA0409, NML " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007252 23378 RRP8 http://www.ncbi.nlm.nih.gov/gene/?term=23378 "KIAA0409, NML " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007253 23379 ICE1 http://www.ncbi.nlm.nih.gov/gene/?term=23379 KIAA0947 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007254 233802 Thumpd1 http://www.ncbi.nlm.nih.gov/gene/?term=233802 6330575P11Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007255 23381 SMG5 http://www.ncbi.nlm.nih.gov/gene/?term=23381 "EST1B, LPTS-RP1, LPTSRP1, SMG-5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007256 233833 Tnrc6a http://www.ncbi.nlm.nih.gov/gene/?term=233833 "2010321I05Rik, 3110054G10Rik, AW557223, CAGH26, D130023A07Rik, GW182, Tnrc6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007257 233833 Tnrc6a http://www.ncbi.nlm.nih.gov/gene/?term=233833 "2010321I05Rik, 3110054G10Rik, AW557223, CAGH26, D130023A07Rik, GW182, Tnrc6 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007258 23383 MAU2 http://www.ncbi.nlm.nih.gov/gene/?term=23383 "KIAA0892L, SCC4, mau-2, MAU2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007259 23384 SPECC1L http://www.ncbi.nlm.nih.gov/gene/?term=23384 "CYTSA, GBBB2, OBLFC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007260 23385 NCSTN http://www.ncbi.nlm.nih.gov/gene/?term=23385 ATAG1874 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007261 23385 NCSTN http://www.ncbi.nlm.nih.gov/gene/?term=23385 ATAG1874 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007262 23386 NUDCD3 http://www.ncbi.nlm.nih.gov/gene/?term=23386 NudCL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007263 233877 Kctd13 http://www.ncbi.nlm.nih.gov/gene/?term=233877 "1500003N18Rik, AV259508, PDIP1alpha, Pdip1, Poldip1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007264 23387 SIK3 http://www.ncbi.nlm.nih.gov/gene/?term=23387 "L19, QSK, SIK-3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007265 23387 SIK3 http://www.ncbi.nlm.nih.gov/gene/?term=23387 "L19, QSK, SIK-3 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007266 23389 MED13L http://www.ncbi.nlm.nih.gov/gene/?term=23389 "MRFACD, PROSIT240, THRAP2, TRAP240L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007267 23389 MED13L http://www.ncbi.nlm.nih.gov/gene/?term=23389 "MRFACD, PROSIT240, THRAP2, TRAP240L " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007268 233905 Zfp646 http://www.ncbi.nlm.nih.gov/gene/?term=233905 6820429M01 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007269 233908 Fus http://www.ncbi.nlm.nih.gov/gene/?term=233908 "D430004D17Rik, D930039C12Rik1, Tls, Fus " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007270 23390 ZDHHC17 http://www.ncbi.nlm.nih.gov/gene/?term=23390 "HIP14, HIP3, HSPC294, HYPH " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007271 23390 ZDHHC17 http://www.ncbi.nlm.nih.gov/gene/?term=23390 "HIP14, HIP3, HSPC294, HYPH " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007272 233918 4933402N03Rik http://www.ncbi.nlm.nih.gov/gene/?term=233918 4930412O05 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007273 23392 KIAA0368 http://www.ncbi.nlm.nih.gov/gene/?term=23392 ECM29 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007274 23394 ADNP http://www.ncbi.nlm.nih.gov/gene/?term=23394 "ADNP1, HVDAS, MRD28 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007275 23394 ADNP http://www.ncbi.nlm.nih.gov/gene/?term=23394 "ADNP1, HVDAS, MRD28 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007276 23395 LARS2 http://www.ncbi.nlm.nih.gov/gene/?term=23395 "LEURS, PRLTS4, mtLeuRS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007277 23395 LARS2 http://www.ncbi.nlm.nih.gov/gene/?term=23395 "LEURS, PRLTS4, mtLeuRS " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00007278 23395 LARS2 http://www.ncbi.nlm.nih.gov/gene/?term=23395 "LEURS, PRLTS4, mtLeuRS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007279 23396 PIP5K1C http://www.ncbi.nlm.nih.gov/gene/?term=23396 "LCCS3, PIP5K-GAMMA, PIP5K1-gamma, PIP5Kgamma " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007280 23397 NCAPH http://www.ncbi.nlm.nih.gov/gene/?term=23397 "BRRN1, CAP-H " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007281 23397 NCAPH http://www.ncbi.nlm.nih.gov/gene/?term=23397 "BRRN1, CAP-H " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007282 23397 NCAPH http://www.ncbi.nlm.nih.gov/gene/?term=23397 "BRRN1, CAP-H " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007283 233987 Zfp958 http://www.ncbi.nlm.nih.gov/gene/?term=233987 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007284 23399 CTDNEP1 http://www.ncbi.nlm.nih.gov/gene/?term=23399 "DULLARD, HSA011916, NET56 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007285 2339 FNTA http://www.ncbi.nlm.nih.gov/gene/?term=2339 "FPTA, PGGT1A, PTAR2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007286 2339 FNTA http://www.ncbi.nlm.nih.gov/gene/?term=2339 "FPTA, PGGT1A, PTAR2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007287 23400 ATP13A2 http://www.ncbi.nlm.nih.gov/gene/?term=23400 "CLN12, HSA9947, KRPPD, PARK9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007288 23401 FRAT2 http://www.ncbi.nlm.nih.gov/gene/?term=23401 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007289 234023 Arglu1 http://www.ncbi.nlm.nih.gov/gene/?term=234023 "9430010O03Rik, C130008N12 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007290 23403 FBXO46 http://www.ncbi.nlm.nih.gov/gene/?term=23403 "20D7-FC4, FBXO34L, Fbx46 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007291 23404 EXOSC2 http://www.ncbi.nlm.nih.gov/gene/?term=23404 "RRP4, Rrp4p, hRrp4p, p7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007292 23405 DICER1 http://www.ncbi.nlm.nih.gov/gene/?term=23405 "DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007293 23405 DICER1 http://www.ncbi.nlm.nih.gov/gene/?term=23405 "DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007294 23405 DICER1 http://www.ncbi.nlm.nih.gov/gene/?term=23405 "DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007295 23406 COTL1 http://www.ncbi.nlm.nih.gov/gene/?term=23406 CLP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007296 23406 COTL1 http://www.ncbi.nlm.nih.gov/gene/?term=23406 CLP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007297 23406 COTL1 http://www.ncbi.nlm.nih.gov/gene/?term=23406 CLP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007298 234076 Tmco3 http://www.ncbi.nlm.nih.gov/gene/?term=234076 "B230339H12Rik, C87304 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007299 23408 SIRT5 http://www.ncbi.nlm.nih.gov/gene/?term=23408 SIR2L5 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007300 23408 SIRT5 http://www.ncbi.nlm.nih.gov/gene/?term=23408 SIR2L5 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007301 23409 SIRT4 http://www.ncbi.nlm.nih.gov/gene/?term=23409 SIR2L4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007302 23410 SIRT3 http://www.ncbi.nlm.nih.gov/gene/?term=23410 SIR2L3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007303 23410 SIRT3 http://www.ncbi.nlm.nih.gov/gene/?term=23410 SIR2L3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007304 23411 SIRT1 http://www.ncbi.nlm.nih.gov/gene/?term=23411 "SIR2, SIR2L1, SIR2alpha " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007305 23411 SIRT1 http://www.ncbi.nlm.nih.gov/gene/?term=23411 "SIR2, SIR2L1, SIR2alpha " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007306 23412 COMMD3 http://www.ncbi.nlm.nih.gov/gene/?term=23412 "BUP, C10orf8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007307 23413 NCS1 http://www.ncbi.nlm.nih.gov/gene/?term=23413 "FLUP, FREQ " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007308 23413 NCS1 http://www.ncbi.nlm.nih.gov/gene/?term=23413 "FLUP, FREQ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007309 234199 Fgl1 http://www.ncbi.nlm.nih.gov/gene/?term=234199 Mfire1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007310 234203 Zfp353-ps http://www.ncbi.nlm.nih.gov/gene/?term=234203 Zfp353 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007311 23420 NOMO1 http://www.ncbi.nlm.nih.gov/gene/?term=23420 "Nomo, PM5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007312 23421 ITGB3BP http://www.ncbi.nlm.nih.gov/gene/?term=23421 "CENP-R, CENPR, HSU37139, NRIF3, TAP20 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007313 23421 ITGB3BP http://www.ncbi.nlm.nih.gov/gene/?term=23421 "CENP-R, CENPR, HSU37139, NRIF3, TAP20 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007314 23423 TMED3 http://www.ncbi.nlm.nih.gov/gene/?term=23423 "C15orf22, P24B, p24g4, p26 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007315 23424 TDRD7 http://www.ncbi.nlm.nih.gov/gene/?term=23424 "CATC4, PCTAIRE2BP, TRAP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007316 23428 SLC7A8 http://www.ncbi.nlm.nih.gov/gene/?term=23428 "LAT2, LPI-PC1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007317 23429 RYBP http://www.ncbi.nlm.nih.gov/gene/?term=23429 "AAP1, APAP-1, DEDAF, YEAF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007318 23429 RYBP http://www.ncbi.nlm.nih.gov/gene/?term=23429 "AAP1, APAP-1, DEDAF, YEAF1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007319 2342 FNTB http://www.ncbi.nlm.nih.gov/gene/?term=2342 FPTB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007320 234309 Cbr4 http://www.ncbi.nlm.nih.gov/gene/?term=234309 "A730083J17Rik, BC009118 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007321 23431 AP4E1 http://www.ncbi.nlm.nih.gov/gene/?term=23431 "CPSQ4, SPG51, STUT1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007322 23431 AP4E1 http://www.ncbi.nlm.nih.gov/gene/?term=23431 "CPSQ4, SPG51, STUT1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007323 23434 LINC01565 http://www.ncbi.nlm.nih.gov/gene/?term=23434 "C3orf27, GR6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007324 23434 LINC01565 http://www.ncbi.nlm.nih.gov/gene/?term=23434 "C3orf27, GR6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007325 23435 TARDBP http://www.ncbi.nlm.nih.gov/gene/?term=23435 "ALS10, TDP-43 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007326 23435 TARDBP http://www.ncbi.nlm.nih.gov/gene/?term=23435 "ALS10, TDP-43 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007327 234366 Gatad2a http://www.ncbi.nlm.nih.gov/gene/?term=234366 "1110066C11Rik, BC031407, C80248 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007328 234374 Ddx49 http://www.ncbi.nlm.nih.gov/gene/?term=234374 R27090_2 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007329 234384 Mpv17l2 http://www.ncbi.nlm.nih.gov/gene/?term=234384 Fksg24 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007330 23438 HARS2 http://www.ncbi.nlm.nih.gov/gene/?term=23438 "HARSL, HARSR, HO3, PRLTS2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007331 23438 HARS2 http://www.ncbi.nlm.nih.gov/gene/?term=23438 "HARSL, HARSR, HO3, PRLTS2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007332 23438 HARS2 http://www.ncbi.nlm.nih.gov/gene/?term=23438 "HARSL, HARSR, HO3, PRLTS2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007333 23439 ATP1B4 http://www.ncbi.nlm.nih.gov/gene/?term=23439 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007334 23439 ATP1B4 http://www.ncbi.nlm.nih.gov/gene/?term=23439 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007335 234404 Nxnl1 http://www.ncbi.nlm.nih.gov/gene/?term=234404 "A930031O08Rik, RdCVF, Txnl6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007336 234413 Zfp961 http://www.ncbi.nlm.nih.gov/gene/?term=234413 "A230105L22Rik, BC065788, mszf37, mszf55-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007337 23443 SLC35A3 http://www.ncbi.nlm.nih.gov/gene/?term=23443 AMRS mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007338 23443 SLC35A3 http://www.ncbi.nlm.nih.gov/gene/?term=23443 AMRS mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007339 234463 Tmem184c http://www.ncbi.nlm.nih.gov/gene/?term=234463 "8430433H16Rik, AI645453, AL033298, BC004056, Tmem34 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007340 23446 SLC44A1 http://www.ncbi.nlm.nih.gov/gene/?term=23446 "CD92, CDW92, CHTL1, CTL1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007341 23446 SLC44A1 http://www.ncbi.nlm.nih.gov/gene/?term=23446 "CD92, CDW92, CHTL1, CTL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007342 23450 SF3B3 http://www.ncbi.nlm.nih.gov/gene/?term=23450 "RSE1, SAP130, SF3b130, STAF130 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007343 23450 SF3B3 http://www.ncbi.nlm.nih.gov/gene/?term=23450 "RSE1, SAP130, SF3b130, STAF130 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007344 23451 SF3B1 http://www.ncbi.nlm.nih.gov/gene/?term=23451 "Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007345 23456 ABCB10 http://www.ncbi.nlm.nih.gov/gene/?term=23456 "EST20237, M-ABC2, MTABC2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007346 23456 ABCB10 http://www.ncbi.nlm.nih.gov/gene/?term=23456 "EST20237, M-ABC2, MTABC2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007347 234594 Cnot1 http://www.ncbi.nlm.nih.gov/gene/?term=234594 "6030411K04Rik, AA815922, D830048B13 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007348 23461 ABCA5 http://www.ncbi.nlm.nih.gov/gene/?term=23461 "ABC13, EST90625 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007349 23461 ABCA5 http://www.ncbi.nlm.nih.gov/gene/?term=23461 "ABC13, EST90625 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007350 23461 ABCA5 http://www.ncbi.nlm.nih.gov/gene/?term=23461 "ABC13, EST90625 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007351 23461 ABCA5 http://www.ncbi.nlm.nih.gov/gene/?term=23461 "ABC13, EST90625 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007352 234624 A330008L17Rik http://www.ncbi.nlm.nih.gov/gene/?term=234624 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007353 23462 HEY1 http://www.ncbi.nlm.nih.gov/gene/?term=23462 "BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007354 23463 ICMT http://www.ncbi.nlm.nih.gov/gene/?term=23463 "HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007355 23463 ICMT http://www.ncbi.nlm.nih.gov/gene/?term=23463 "HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007356 23463 ICMT http://www.ncbi.nlm.nih.gov/gene/?term=23463 "HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007357 23463 ICMT http://www.ncbi.nlm.nih.gov/gene/?term=23463 "HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007358 23463 ICMT http://www.ncbi.nlm.nih.gov/gene/?term=23463 "HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007359 23464 GCAT http://www.ncbi.nlm.nih.gov/gene/?term=23464 KBL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007360 23464 GCAT http://www.ncbi.nlm.nih.gov/gene/?term=23464 KBL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007361 234663 Dync1li2 http://www.ncbi.nlm.nih.gov/gene/?term=234663 "AA409702, C920003I06, Dncli2, Dnclic2, LIC2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007362 23466 CBX6 http://www.ncbi.nlm.nih.gov/gene/?term=23466 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007363 23466 CBX6 http://www.ncbi.nlm.nih.gov/gene/?term=23466 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007364 23468 CBX5 http://www.ncbi.nlm.nih.gov/gene/?term=23468 "HEL25, HP1, HP1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007365 23468 CBX5 http://www.ncbi.nlm.nih.gov/gene/?term=23468 "HEL25, HP1, HP1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007366 23468 CBX5 http://www.ncbi.nlm.nih.gov/gene/?term=23468 "HEL25, HP1, HP1A " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007367 23468 CBX5 http://www.ncbi.nlm.nih.gov/gene/?term=23468 "HEL25, HP1, HP1A " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007368 234695 Rltpr http://www.ncbi.nlm.nih.gov/gene/?term=234695 "CARMIL2, CG1399-PB, D130029J02Rik, Gm585 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007369 23469 PHF3 http://www.ncbi.nlm.nih.gov/gene/?term=23469 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007370 23469 PHF3 http://www.ncbi.nlm.nih.gov/gene/?term=23469 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007371 234703 Rpl10-ps2 http://www.ncbi.nlm.nih.gov/gene/?term=234703 "EG234703, Gm4892 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007372 23471 TRAM1 http://www.ncbi.nlm.nih.gov/gene/?term=23471 "PNAS8, TRAM, TRAMP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007373 23471 TRAM1 http://www.ncbi.nlm.nih.gov/gene/?term=23471 "PNAS8, TRAM, TRAMP " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007374 23471 TRAM1 http://www.ncbi.nlm.nih.gov/gene/?term=23471 "PNAS8, TRAM, TRAMP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007375 234723 Txnl4b http://www.ncbi.nlm.nih.gov/gene/?term=234723 "AI595343, D530025J19Rik, DLP, Dim2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007376 234725 Zfp612 http://www.ncbi.nlm.nih.gov/gene/?term=234725 B230354B21Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007377 23473 CAPN7 http://www.ncbi.nlm.nih.gov/gene/?term=23473 "CALPAIN7, PALBH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007378 23473 CAPN7 http://www.ncbi.nlm.nih.gov/gene/?term=23473 "CALPAIN7, PALBH " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007379 23474 ETHE1 http://www.ncbi.nlm.nih.gov/gene/?term=23474 "HSCO, YF13H12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007380 23475 QPRT http://www.ncbi.nlm.nih.gov/gene/?term=23475 "HEL-S-90n, QPRTase " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007381 23475 QPRT http://www.ncbi.nlm.nih.gov/gene/?term=23475 "HEL-S-90nase, QPRT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007382 23476 BRD4 http://www.ncbi.nlm.nih.gov/gene/?term=23476 "CAP, HUNK1, HUNKI, MCAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007383 234797 6430548M08Rik http://www.ncbi.nlm.nih.gov/gene/?term=234797 "AW049007, Kiaa0513, mKIAA0513 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007384 23479 ISCU http://www.ncbi.nlm.nih.gov/gene/?term=23479 "2310020H20Rik, HML, ISU2, NIFU, NIFUN, hnifU " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007385 23479 ISCU http://www.ncbi.nlm.nih.gov/gene/?term=23479 "2310020H20Rik, HML, ISU2, NIFU, NIFUN, hnifU " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007386 23479 ISCU http://www.ncbi.nlm.nih.gov/gene/?term=23479 "2310020H20Rik, HML, ISU2, NIFU, NIFUN, hnifU " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007387 23480 SEC61G http://www.ncbi.nlm.nih.gov/gene/?term=23480 SSS1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007388 23480 SEC61G http://www.ncbi.nlm.nih.gov/gene/?term=23480 SSS1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007389 23480 SEC61G http://www.ncbi.nlm.nih.gov/gene/?term=23480 SSS1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007390 23481 PES1 http://www.ncbi.nlm.nih.gov/gene/?term=23481 PES mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007391 23481 PES1 http://www.ncbi.nlm.nih.gov/gene/?term=23481 PES mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007392 234847 Spg7 http://www.ncbi.nlm.nih.gov/gene/?term=234847 "AI452278, AU015315, Cmar, PGN " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007393 234847 Spg7 http://www.ncbi.nlm.nih.gov/gene/?term=234847 "AI452278, AU015315, Cmar, PGN " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007394 23484 LEPROTL1 http://www.ncbi.nlm.nih.gov/gene/?term=23484 "HSPC112, Vps55, my047 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007395 23484 LEPROTL1 http://www.ncbi.nlm.nih.gov/gene/?term=23484 "HSPC112, Vps55, my047 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007396 234852 Chmp1a http://www.ncbi.nlm.nih.gov/gene/?term=234852 "2900018H07Rik, Pcoln3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007397 234857 Spire2 http://www.ncbi.nlm.nih.gov/gene/?term=234857 "BC026502, Spir-2, Spir2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007398 234875 Ttc13 http://www.ncbi.nlm.nih.gov/gene/?term=234875 BC017545 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007399 2348 FOLR1 http://www.ncbi.nlm.nih.gov/gene/?term=2348 "FBP, FOLR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007400 234967 Slc36a4 http://www.ncbi.nlm.nih.gov/gene/?term=234967 "6330573I15Rik, PAT4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007401 23498 HAAO http://www.ncbi.nlm.nih.gov/gene/?term=23498 "3-HAO, HAO " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007402 23499 MACF1 http://www.ncbi.nlm.nih.gov/gene/?term=23499 "ABP620, ACF7, MACF, OFC4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007403 23499 MACF1 http://www.ncbi.nlm.nih.gov/gene/?term=23499 "ABP620, ACF7, MACF, OFC4 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007404 23499 MACF1 http://www.ncbi.nlm.nih.gov/gene/?term=23499 "ABP620, ACF7, MACF, OFC4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007405 235040 Atg4d http://www.ncbi.nlm.nih.gov/gene/?term=235040 "9830134P12Rik, APG4-D, Apg4dl, Autl4, Atg4d " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007406 235047 Zfp809 http://www.ncbi.nlm.nih.gov/gene/?term=235047 "BB114266, C330026E23 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007407 23505 TMEM131 http://www.ncbi.nlm.nih.gov/gene/?term=23505 "CC28, PRO1048, RW1, YR-23 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007408 23506 GLTSCR1L http://www.ncbi.nlm.nih.gov/gene/?term=23506 KIAA0240 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007409 235072 Sept7 http://www.ncbi.nlm.nih.gov/gene/?term=235072 "Cdc10, E430034N22 " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00007410 23507 LRRC8B http://www.ncbi.nlm.nih.gov/gene/?term=23507 "TA-LRRP, TALRRP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007411 23509 POFUT1 http://www.ncbi.nlm.nih.gov/gene/?term=23509 "DDD2, FUT12, O-FUT, O-Fuc-T, O-FucT-1, OFUCT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007412 23509 POFUT1 http://www.ncbi.nlm.nih.gov/gene/?term=23509 "DDD2, FUT12, O-FUT, O-Fuc-T, O-FucT-1, OFUCT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007413 23509 POFUT1 http://www.ncbi.nlm.nih.gov/gene/?term=23509 "DDD2, FUT12, O-FUT, O-Fuc-T, O-FucT-1, OFUCT1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007414 23509 POFUT1 http://www.ncbi.nlm.nih.gov/gene/?term=23509 "DDD2, FUT12, O-FUT, O-Fuc-T, O-FucT-1, OFUCT1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007415 2350 FOLR2 http://www.ncbi.nlm.nih.gov/gene/?term=2350 "BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007416 235106 Ntm http://www.ncbi.nlm.nih.gov/gene/?term=235106 "6230410L23Rik, B230210G24Rik, Hnt, Igdcc2, R75390 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007417 23510 KCTD2 http://www.ncbi.nlm.nih.gov/gene/?term=23510 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007418 23510 KCTD2 http://www.ncbi.nlm.nih.gov/gene/?term=23510 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007419 23511 NUP188 http://www.ncbi.nlm.nih.gov/gene/?term=23511 "KIAA0169, hNup188 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007420 23512 SUZ12 http://www.ncbi.nlm.nih.gov/gene/?term=23512 "CHET9, JJAZ1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007421 235132 Zbtb44 http://www.ncbi.nlm.nih.gov/gene/?term=235132 "6030404E16Rik, Btbd15, E230011F09 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007422 23513 SCRIB http://www.ncbi.nlm.nih.gov/gene/?term=23513 "CRIB1, SCRB11, Vartul, SCRIB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007423 23514 SPIDR http://www.ncbi.nlm.nih.gov/gene/?term=23514 KIAA0146 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007424 23515 MORC3 http://www.ncbi.nlm.nih.gov/gene/?term=23515 "NXP2, ZCW5, ZCWCC3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007425 23515 MORC3 http://www.ncbi.nlm.nih.gov/gene/?term=23515 "NXP2, ZCW5, ZCWCC3 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007426 23516 SLC39A14 http://www.ncbi.nlm.nih.gov/gene/?term=23516 "LZT-Hs4, NET34, ZIP14, cig19 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007427 23516 SLC39A14 http://www.ncbi.nlm.nih.gov/gene/?term=23516 "LZT-Hs4, NET34, ZIP14, cig19 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007428 235184 Msantd2 http://www.ncbi.nlm.nih.gov/gene/?term=235184 "2810450G17Rik, 9530092B10Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007429 23518 R3HDM1 http://www.ncbi.nlm.nih.gov/gene/?term=23518 R3HDM mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007430 23518 R3HDM1 http://www.ncbi.nlm.nih.gov/gene/?term=23518 R3HDM mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007431 23521 RPL13A http://www.ncbi.nlm.nih.gov/gene/?term=23521 "L13A, TSTA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007432 23521 RPL13A http://www.ncbi.nlm.nih.gov/gene/?term=23521 "L13A, TSTA1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007433 23521 RPL13A http://www.ncbi.nlm.nih.gov/gene/?term=23521 "L13A, TSTA1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007434 23521 RPL13A http://www.ncbi.nlm.nih.gov/gene/?term=23521 "L13A, TSTA1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007435 23523 CABIN1 http://www.ncbi.nlm.nih.gov/gene/?term=23523 "CAIN, KB-318B8.7, PPP3IN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007436 23524 SRRM2 http://www.ncbi.nlm.nih.gov/gene/?term=23524 "300-KD, CWF21, Cwc21, HSPC075, SRL300, SRm300 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007437 23526 HMHA1 http://www.ncbi.nlm.nih.gov/gene/?term=23526 "ARHGAP45, HA-1, HLA-HA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007438 23527 ACAP2 http://www.ncbi.nlm.nih.gov/gene/?term=23527 "CENTB2, CNT-B2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007439 23527 ACAP2 http://www.ncbi.nlm.nih.gov/gene/?term=23527 "CENTB2, CNT-B2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007440 23527 ACAP2 http://www.ncbi.nlm.nih.gov/gene/?term=23527 "CENTB2, CNT-B2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007441 235283 Gramd1b http://www.ncbi.nlm.nih.gov/gene/?term=235283 "3222402H23, A930008A22Rik, AI593249, mKIAA1201 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007442 23528 ZNF281 http://www.ncbi.nlm.nih.gov/gene/?term=23528 "ZBP-99, ZNP-99 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007443 2352 FOLR3 http://www.ncbi.nlm.nih.gov/gene/?term=2352 "FR-G, FR-gamma, gamma-hFR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007444 23530 NNT http://www.ncbi.nlm.nih.gov/gene/?term=23530 GCCD4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007445 23530 NNT http://www.ncbi.nlm.nih.gov/gene/?term=23530 GCCD4 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007446 23531 MMD http://www.ncbi.nlm.nih.gov/gene/?term=23531 "MMA, MMD1, PAQR11 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007447 23531 MMD http://www.ncbi.nlm.nih.gov/gene/?term=23531 "MMA1, PAQR11, MMD " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007448 23531 MMD http://www.ncbi.nlm.nih.gov/gene/?term=23531 "MMA1, PAQR11, MMD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007449 23532 PRAME http://www.ncbi.nlm.nih.gov/gene/?term=23532 "CT130, MAPE, OIP-4, OIP4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007450 23534 TNPO3 http://www.ncbi.nlm.nih.gov/gene/?term=23534 "IPO12, LGMD1F, MTR10A, TRN-SR, TRN-SR2, TRNSR " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007451 23536 ADAT1 http://www.ncbi.nlm.nih.gov/gene/?term=23536 HADAT1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007452 235379 Gldn http://www.ncbi.nlm.nih.gov/gene/?term=235379 "CRG-L2, Clom, Colm, Crgl2, Crlg2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007453 235380 Dmxl2 http://www.ncbi.nlm.nih.gov/gene/?term=235380 "6330586A12, 6430411K14Rik, E130119P06Rik, mKIAA0856 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007454 2353 FOS http://www.ncbi.nlm.nih.gov/gene/?term=2353 "AP-1, C-FOS, p55 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007455 2353 FOS http://www.ncbi.nlm.nih.gov/gene/?term=2353 "AP-1, C-FOS, p55 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007456 235431 Coro2b http://www.ncbi.nlm.nih.gov/gene/?term=235431 "CLIPINC, E130012P22Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007457 235435 Lctl http://www.ncbi.nlm.nih.gov/gene/?term=235435 "E130104I05Rik, KLPH " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007458 235439 Herc1 http://www.ncbi.nlm.nih.gov/gene/?term=235439 "2810449H11Rik, B230218H07, D130015N03Rik, tbl " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007459 23543 RBFOX2 http://www.ncbi.nlm.nih.gov/gene/?term=23543 "FOX2, Fox-2, HNRBP2, HRNBP2, RBM9, RTA, dJ106I20.3, fxh " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007460 23543 RBFOX2 http://www.ncbi.nlm.nih.gov/gene/?term=23543 "FOX2, Fox-2, HNRBP2, HRNBP2, RBM9, RTA, dJ106I20.3, fxh " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007461 235459 Gtf2a2 http://www.ncbi.nlm.nih.gov/gene/?term=235459 "TFIIA-gamma, TfIIg, Tfiia2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007462 23545 ATP6V0A2 http://www.ncbi.nlm.nih.gov/gene/?term=23545 "A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007463 23545 ATP6V0A2 http://www.ncbi.nlm.nih.gov/gene/?term=23545 "A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007464 23545 ATP6V0A2 http://www.ncbi.nlm.nih.gov/gene/?term=23545 "A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007465 235469 Zfp280d http://www.ncbi.nlm.nih.gov/gene/?term=235469 "A930005F02Rik, BC027163, Suhw4, ZNF634, Znf280d " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007466 23547 LILRA4 http://www.ncbi.nlm.nih.gov/gene/?term=23547 "CD85g, ILT7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007467 23548 TTC33 http://www.ncbi.nlm.nih.gov/gene/?term=23548 OSRF mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007468 235497 Leo1 http://www.ncbi.nlm.nih.gov/gene/?term=235497 Gm185 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007469 23549 DNPEP http://www.ncbi.nlm.nih.gov/gene/?term=23549 "ASPEP, DAP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007470 2354 FOSB http://www.ncbi.nlm.nih.gov/gene/?term=2354 "AP-1, G0S3, GOS3, GOSB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007471 235504 Slc17a5 http://www.ncbi.nlm.nih.gov/gene/?term=235504 "4631416G20Rik, 4732491M05, AST, ISSD, NSD, SD, SIALIN, SIASD, SLD " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007472 23553 HYAL4 http://www.ncbi.nlm.nih.gov/gene/?term=23553 CSHY mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007473 235542 Ppp2r3a http://www.ncbi.nlm.nih.gov/gene/?term=235542 "3222402P14Rik, A730042E07 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007474 23554 TSPAN12 http://www.ncbi.nlm.nih.gov/gene/?term=23554 "EVR5, NET-2, NET2, TM4SF12 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007475 23554 TSPAN12 http://www.ncbi.nlm.nih.gov/gene/?term=23554 "EVR5, NET-2, NET2, TM4SF12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007476 235559 Topbp1 http://www.ncbi.nlm.nih.gov/gene/?term=235559 "1110031N14Rik, 2810429C13Rik, AI256758, D430026L04Rik, mKIAA0259 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007477 23555 TSPAN15 http://www.ncbi.nlm.nih.gov/gene/?term=23555 "2700063A19Rik, NET-7, NET7, TM4SF15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007478 23555 TSPAN15 http://www.ncbi.nlm.nih.gov/gene/?term=23555 "2700063A19Rik, NET-7, NET7, TM4SF15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007479 23555 TSPAN15 http://www.ncbi.nlm.nih.gov/gene/?term=23555 "2700063A19Rik, NET-7, NET7, TM4SF15 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007480 235567 Dnajc13 http://www.ncbi.nlm.nih.gov/gene/?term=235567 "D030002L11Rik, Gm1124, RME-8, Rme8, mKIAA0678 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007481 23556 PIGN http://www.ncbi.nlm.nih.gov/gene/?term=23556 "MCAHS, MCAHS1, MCD4, MDC4, PIG-N " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007482 23556 PIGN http://www.ncbi.nlm.nih.gov/gene/?term=23556 "MCAHS, MCAHS1, MCD4, MDC4, PIG-N " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007483 23556 PIGN http://www.ncbi.nlm.nih.gov/gene/?term=23556 "MCAHS, MCAHS1, MCD4, MDC4, PIG-N " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007484 235574 Atp2c1 http://www.ncbi.nlm.nih.gov/gene/?term=235574 "1700121J11Rik, ATP2C1A, AW061228, BCPM, D930003G21Rik, HHD, SPCA, pmr1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007485 23557 SNAPIN http://www.ncbi.nlm.nih.gov/gene/?term=23557 "BLOC1S7, BLOS7, BORCS3, SNAPAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007486 23557 SNAPIN http://www.ncbi.nlm.nih.gov/gene/?term=23557 "BLOC1S7, BLOS7, BORCS3, SNAPAP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007487 23557 SNAPIN http://www.ncbi.nlm.nih.gov/gene/?term=23557 "BLOC1S7, BLOS7, BORCS3, SNAPAP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007488 23558 WBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23558 "GRAMD6, WBP-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007489 23558 WBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23558 "GRAMD6, WBP-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007490 2355 FOSL2 http://www.ncbi.nlm.nih.gov/gene/?term=2355 FRA2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007491 2355 FOSL2 http://www.ncbi.nlm.nih.gov/gene/?term=2355 FRA2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007492 23560 GTPBP4 http://www.ncbi.nlm.nih.gov/gene/?term=23560 "CRFG, NGB, NOG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007493 23560 GTPBP4 http://www.ncbi.nlm.nih.gov/gene/?term=23560 "CRFG, NGB, NOG1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007494 23560 GTPBP4 http://www.ncbi.nlm.nih.gov/gene/?term=23560 "CRFG, NGB, NOG1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007495 235626 Setd2 http://www.ncbi.nlm.nih.gov/gene/?term=235626 "4921524K10Rik, BC031601, KMT3A " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007496 23563 CHST5 http://www.ncbi.nlm.nih.gov/gene/?term=23563 "I-GlcNAc-6-ST, I-GlcNAc6ST, glcNAc6ST-3, gn6st-3, hIGn6ST " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007497 23563 CHST5 http://www.ncbi.nlm.nih.gov/gene/?term=23563 "I-GlcNAc-6-ST, I-GlcNAc6ST, glcNAc6ST-3, gn6st-3, hIGn6ST " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007498 235661 Dync1li1 http://www.ncbi.nlm.nih.gov/gene/?term=235661 "1110053F02Rik, Dnclic1, LIC-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007499 235682 Zfp445 http://www.ncbi.nlm.nih.gov/gene/?term=235682 "AW610627, ZNF168, Znf445, mszf29, mszf50 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007500 23568 ARL2BP http://www.ncbi.nlm.nih.gov/gene/?term=23568 "BART, BART1, RP66 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007501 23568 ARL2BP http://www.ncbi.nlm.nih.gov/gene/?term=23568 "BART, BART1, RP66 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007502 23568 ARL2BP http://www.ncbi.nlm.nih.gov/gene/?term=23568 "BART, BART1, RP66 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007503 2356 FPGS http://www.ncbi.nlm.nih.gov/gene/?term=2356 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007504 2356 FPGS http://www.ncbi.nlm.nih.gov/gene/?term=2356 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007505 23576 DDAH1 http://www.ncbi.nlm.nih.gov/gene/?term=23576 "DDAH, HEL-S-16 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007506 23580 CDC42EP4 http://www.ncbi.nlm.nih.gov/gene/?term=23580 "BORG4, CEP4, KAIA1777 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007507 23580 CDC42EP4 http://www.ncbi.nlm.nih.gov/gene/?term=23580 "BORG4, CEP4, KAIA1777 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007508 23580 CDC42EP4 http://www.ncbi.nlm.nih.gov/gene/?term=23580 "BORG4, CEP4, KAIA1777 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007509 23582 CCNDBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23582 "DIP1, GCIP, HHM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007510 23582 CCNDBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23582 "DIP1, GCIP, HHM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007511 23582 CCNDBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23582 "DIP1, GCIP, HHM " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007512 23583 SMUG1 http://www.ncbi.nlm.nih.gov/gene/?term=23583 "FDG, HMUDG, UNG3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007513 23585 TMEM50A http://www.ncbi.nlm.nih.gov/gene/?term=23585 "IFNRC, SMP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007514 23586 DDX58 http://www.ncbi.nlm.nih.gov/gene/?term=23586 "RIG-I, RIGI, RLR-1, SGMRT2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007515 23586 DDX58 http://www.ncbi.nlm.nih.gov/gene/?term=23586 "RIG-I, RIGI, RLR-1, SGMRT2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007516 23587 ELP5 http://www.ncbi.nlm.nih.gov/gene/?term=23587 "C17orf81, DERP6, HSPC002, MST071, MSTP071 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007517 23588 KLHDC2 http://www.ncbi.nlm.nih.gov/gene/?term=23588 "HCLP-1, HCLP1, LCP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007518 23588 KLHDC2 http://www.ncbi.nlm.nih.gov/gene/?term=23588 "HCLP-1, HCLP1, LCP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007519 23589 CARHSP1 http://www.ncbi.nlm.nih.gov/gene/?term=23589 "CRHSP-24, CSDC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007520 23589 CARHSP1 http://www.ncbi.nlm.nih.gov/gene/?term=23589 "CRHSP-24, CRHSP24, CSDC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007521 23589 CARHSP1 http://www.ncbi.nlm.nih.gov/gene/?term=23589 "CRHSP-24, CRHSP24, CSDC1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007522 23589 CARHSP1 http://www.ncbi.nlm.nih.gov/gene/?term=23589 "CRHSP-24, CRHSP24, CSDC1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007523 23589 CARHSP1 http://www.ncbi.nlm.nih.gov/gene/?term=23589 "CRHSP-24, CRHSP24, CSDC1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007524 23590 PDSS1 http://www.ncbi.nlm.nih.gov/gene/?term=23590 "COQ1, COQ10D2, DPS, SPS, TPRT, TPT, TPT 1, hDPS1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007525 23592 LEMD3 http://www.ncbi.nlm.nih.gov/gene/?term=23592 MAN1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007526 23592 LEMD3 http://www.ncbi.nlm.nih.gov/gene/?term=23592 MAN1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007527 23593 HEBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23593 "C6ORF34B, C6orf34, PP23, SOUL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007528 23593 HEBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23593 "C6ORF34B, C6orf34, PP23, SOUL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007529 23593 HEBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23593 "C6ORF34B, C6orf34, PP23, SOUL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007530 23594 ORC6 http://www.ncbi.nlm.nih.gov/gene/?term=23594 ORC6L mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007531 23594 ORC6 http://www.ncbi.nlm.nih.gov/gene/?term=23594 ORC6L mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007532 23595 ORC3 http://www.ncbi.nlm.nih.gov/gene/?term=23595 "LAT, LATHEO, ORC3L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007533 23595 ORC3 http://www.ncbi.nlm.nih.gov/gene/?term=23595 "LAT, LATHEOL, ORC3 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007534 23596 OPN3 http://www.ncbi.nlm.nih.gov/gene/?term=23596 "ECPN, PPP1R116 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007535 23597 ACOT9 http://www.ncbi.nlm.nih.gov/gene/?term=23597 "ACATE2, CGI-16, MT-ACT48, MTACT48 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007536 23598 PATZ1 http://www.ncbi.nlm.nih.gov/gene/?term=23598 "MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG, dJ400N23 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007537 23600 AMACR http://www.ncbi.nlm.nih.gov/gene/?term=23600 "AMACRD, CBAS4, RACE, RM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007538 23603 CORO1C http://www.ncbi.nlm.nih.gov/gene/?term=23603 HCRNN4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007539 23603 CORO1C http://www.ncbi.nlm.nih.gov/gene/?term=23603 HCRNN4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007540 23607 CD2AP http://www.ncbi.nlm.nih.gov/gene/?term=23607 CMS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007541 23607 CD2AP http://www.ncbi.nlm.nih.gov/gene/?term=23607 CMS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007542 23607 CD2AP http://www.ncbi.nlm.nih.gov/gene/?term=23607 CMS mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007543 23608 MKRN1 http://www.ncbi.nlm.nih.gov/gene/?term=23608 RNF61 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007544 23609 MKRN2 http://www.ncbi.nlm.nih.gov/gene/?term=23609 "HSPC070, RNF62 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007545 23612 PHLDA3 http://www.ncbi.nlm.nih.gov/gene/?term=23612 TIH1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007546 23613 ZMYND8 http://www.ncbi.nlm.nih.gov/gene/?term=23613 "PRKCBP1, PRO2893, RACK7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007547 23614 PPY2P http://www.ncbi.nlm.nih.gov/gene/?term=23614 PPY2 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007548 23614 PPY2P http://www.ncbi.nlm.nih.gov/gene/?term=23614 PPY2 lncRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00007549 23623 RUSC1 http://www.ncbi.nlm.nih.gov/gene/?term=23623 NESCA mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007550 23624 CBLC http://www.ncbi.nlm.nih.gov/gene/?term=23624 "CBL-3, CBL-SL, RNF57 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007551 23625 FAM89B http://www.ncbi.nlm.nih.gov/gene/?term=23625 "LRAP25, MTVR, MTVR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007552 236266 Alms1 http://www.ncbi.nlm.nih.gov/gene/?term=236266 bbb mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007553 23627 PRND http://www.ncbi.nlm.nih.gov/gene/?term=23627 "DOPPEL, DPL, PrPLP, dJ1068H6.4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007554 23627 PRND http://www.ncbi.nlm.nih.gov/gene/?term=23627 "DOPPEL, DPL, PrPLP, dJ1068H6.4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007555 23633 KPNA6 http://www.ncbi.nlm.nih.gov/gene/?term=23633 "IPOA7, KPNA7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007556 23633 KPNA6 http://www.ncbi.nlm.nih.gov/gene/?term=23633 "IPOA7, KPNA7 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007557 23633 KPNA6 http://www.ncbi.nlm.nih.gov/gene/?term=23633 "IPOA7, KPNA7 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007558 23635 SSBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23635 "HSPC116, SOSS-B2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007559 23635 SSBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23635 "HSPC116, SOSS-B2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007560 236366 5730507C01Rik http://www.ncbi.nlm.nih.gov/gene/?term=236366 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007561 23636 NUP62 http://www.ncbi.nlm.nih.gov/gene/?term=23636 "IBSN, SNDI, p62 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007562 23637 RABGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=23637 "GAPCENA, TBC1D11 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007563 23640 HSPBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23640 FES1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007564 23640 HSPBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23640 FES1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007565 23642 SNHG1 http://www.ncbi.nlm.nih.gov/gene/?term=23642 "LINC00057, NCRNA00057, U22HG, UHG " lncRNA Homo sapiens 9671460 Cytoplasm HeLa cell Northern blot "We investigated the cellular localization of the U17HG RNA. Cell fractionation experiments indicated that U17HG RNA is enriched in the cytoplasm (Fig.5A), similar to UHG RNA, another noncoding snoRNA host having no protein-coding potential (Fig.5B). As expected, U17 snoRNA, used as a control, was found mainly in the nuclear fraction (Fig.5C). " RLID00007566 23642 SNHG1 http://www.ncbi.nlm.nih.gov/gene/?term=23642 "LINC00057, NCRNA00057, U22HG, UHG " lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007567 23644 EDC4 http://www.ncbi.nlm.nih.gov/gene/?term=23644 "GE1, Ge-1, HEDL5, HEDLS, RCD-8, RCD8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007568 23644 EDC4 http://www.ncbi.nlm.nih.gov/gene/?term=23644 "GE1, Ge-1, HEDL5, HEDLS, RCD-8, RCD8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007569 23645 PPP1R15A http://www.ncbi.nlm.nih.gov/gene/?term=23645 GADD34 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007570 23646 PLD3 http://www.ncbi.nlm.nih.gov/gene/?term=23646 "AD19, HU-K4, HUK4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007571 23647 ARFIP2 http://www.ncbi.nlm.nih.gov/gene/?term=23647 POR1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007572 23647 ARFIP2 http://www.ncbi.nlm.nih.gov/gene/?term=23647 POR1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007573 23647 ARFIP2 http://www.ncbi.nlm.nih.gov/gene/?term=23647 POR1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007574 23648 SSBP3 http://www.ncbi.nlm.nih.gov/gene/?term=23648 "CSDP, SSDP, SSDP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007575 23649 POLA2 http://www.ncbi.nlm.nih.gov/gene/?term=23649 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007576 23650 TRIM29 http://www.ncbi.nlm.nih.gov/gene/?term=23650 ATDC mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007577 23650 TRIM29 http://www.ncbi.nlm.nih.gov/gene/?term=23650 ATDC mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007578 236537 Zfp352 http://www.ncbi.nlm.nih.gov/gene/?term=236537 2czf48 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007579 236537 Zfp352 http://www.ncbi.nlm.nih.gov/gene/?term=236537 2czf48 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007580 236539 Phgdh http://www.ncbi.nlm.nih.gov/gene/?term=236539 "3-PGDH, 3PGDH, 4930479N23, A10, PGAD, PGD, PGDH, SERA " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007581 23654 PLXNB2 http://www.ncbi.nlm.nih.gov/gene/?term=23654 "MM1, Nbla00445, PLEXB2, dJ402G11.3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007582 23657 SLC7A11 http://www.ncbi.nlm.nih.gov/gene/?term=23657 "CCBR1, xCT " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007583 23657 SLC7A11 http://www.ncbi.nlm.nih.gov/gene/?term=23657 "CCBR1, xCT " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007584 23658 LSM5 http://www.ncbi.nlm.nih.gov/gene/?term=23658 YER146W mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007585 23658 LSM5 http://www.ncbi.nlm.nih.gov/gene/?term=23658 YER146W mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007586 236598 Rn28s1 http://www.ncbi.nlm.nih.gov/gene/?term=236598 28s rRNA Mus musculus 25847616 Mitochondrion Liver Next-generation sequencing|qRT-PCR "Both the 28S rRNA and RNase P RNAs were found in the mitochondrial pellet, even at the highest digitonin concentration, where the pellet likely consisted primarily of ruptured inner mitochondrial membranes, suggesting a potential association with the inner mitochondrial membrane. " RLID00007587 23659 PLA2G15 http://www.ncbi.nlm.nih.gov/gene/?term=23659 "ACS, GXVPLA2, LLPL, LPLA2, LYPLA3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007588 23660 ZKSCAN5 http://www.ncbi.nlm.nih.gov/gene/?term=23660 "ZFP-95, ZFP95, ZNF914, ZSCAN37 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007589 236643 Sytl5 http://www.ncbi.nlm.nih.gov/gene/?term=236643 "ENSMUSG00000054453, slp5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007590 23666 UBBP4 http://www.ncbi.nlm.nih.gov/gene/?term=23666 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007591 23670 TMEM2 http://www.ncbi.nlm.nih.gov/gene/?term=23670 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007592 23670 TMEM2 http://www.ncbi.nlm.nih.gov/gene/?term=23670 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007593 236732 Rbm10 http://www.ncbi.nlm.nih.gov/gene/?term=236732 E430039K10Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007594 23673 STX12 http://www.ncbi.nlm.nih.gov/gene/?term=23673 "STX13, STX14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007595 236790 Ddx26b http://www.ncbi.nlm.nih.gov/gene/?term=236790 "4930535D10Rik, 6330505F04Rik, D130066O12 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007596 23682 RAB38 http://www.ncbi.nlm.nih.gov/gene/?term=23682 "NY-MEL-1, rrGTPbp " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007597 23682 RAB38 http://www.ncbi.nlm.nih.gov/gene/?term=23682 "NY-MEL-1, rrGTPbp " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007598 23682 RAB38 http://www.ncbi.nlm.nih.gov/gene/?term=23682 "NY-MEL-1, rrGTPbp " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007599 23683 PRKD3 http://www.ncbi.nlm.nih.gov/gene/?term=23683 "EPK2, PKC-NU, PKD3, PRKCN, nPKC-NU " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007600 236930 Ercc6l http://www.ncbi.nlm.nih.gov/gene/?term=236930 "BC004701, D330021P09Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007601 23704 KCNE4 http://www.ncbi.nlm.nih.gov/gene/?term=23704 MIRP3 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007602 23704 KCNE4 http://www.ncbi.nlm.nih.gov/gene/?term=23704 MIRP3 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007603 23708 GSPT2 http://www.ncbi.nlm.nih.gov/gene/?term=23708 "ERF3B, GST2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007604 23708 GSPT2 http://www.ncbi.nlm.nih.gov/gene/?term=23708 "ERF3B, GST2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007605 23710 GABARAPL1 http://www.ncbi.nlm.nih.gov/gene/?term=23710 "APG8-LIKE, APG8L, ATG8, ATG8B, ATG8L, GEC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007606 23710 GABARAPL1 http://www.ncbi.nlm.nih.gov/gene/?term=23710 "APG8-LIKE, APG8L, ATG8, ATG8B, ATG8L, GEC1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007607 237253 Lrp11 http://www.ncbi.nlm.nih.gov/gene/?term=237253 "1700034J19Rik, 6330533B21, 9830160H19Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007608 237300 Gm4922 http://www.ncbi.nlm.nih.gov/gene/?term=237300 "4933423E17, EG237300 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007609 237310 Il22ra2 http://www.ncbi.nlm.nih.gov/gene/?term=237310 "CRF2-10, CRF2-s1, CRF2X, Il-22bp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007610 23731 TMEM245 http://www.ncbi.nlm.nih.gov/gene/?term=23731 "C9orf5, CG-2, CG2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007611 23731 TMEM245 http://www.ncbi.nlm.nih.gov/gene/?term=23731 "C9orf5, CG-2, CG2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007612 237336 Tbpl1 http://www.ncbi.nlm.nih.gov/gene/?term=237336 "4732475G08, AW011832, AW491032, D18347, STD, TLF, TRF2, TRP, Tlp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007613 23741 EID1 http://www.ncbi.nlm.nih.gov/gene/?term=23741 "C15orf3, CRI1, EID-1, IRO45620, PNAS-22, PTD014, RBP21 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007614 237422 Ric8b http://www.ncbi.nlm.nih.gov/gene/?term=237422 "BC051080, Ric-8, Ric-8b " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007615 23742 NPAP1 http://www.ncbi.nlm.nih.gov/gene/?term=23742 C15orf2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007616 23742 NPAP1 http://www.ncbi.nlm.nih.gov/gene/?term=23742 C15orf2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007617 237436 Gas2l3 http://www.ncbi.nlm.nih.gov/gene/?term=237436 "8430435B07Rik, Gm240 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007618 237459 Cdk17 http://www.ncbi.nlm.nih.gov/gene/?term=237459 "6430598J10Rik, Pctk2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007619 237465 Ccdc38 http://www.ncbi.nlm.nih.gov/gene/?term=237465 4933417K05Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007620 237500 Tmtc3 http://www.ncbi.nlm.nih.gov/gene/?term=237500 "9130014E20Rik, B130008E12Rik, mSmile " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007621 23753 SDF2L1 http://www.ncbi.nlm.nih.gov/gene/?term=23753 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007622 23753 SDF2L1 http://www.ncbi.nlm.nih.gov/gene/?term=23753 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007623 237542 Osbpl8 http://www.ncbi.nlm.nih.gov/gene/?term=237542 "AA536976, AA536995, C730029P18Rik, D330025H14Rik, ORP-8 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007624 237553 Trhde http://www.ncbi.nlm.nih.gov/gene/?term=237553 9330155P21Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007625 237560 Lrrc10 http://www.ncbi.nlm.nih.gov/gene/?term=237560 "D330003I11Rik, Hrlrrp, Serdin1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007626 23759 PPIL2 http://www.ncbi.nlm.nih.gov/gene/?term=23759 "CYC4, CYP60, Cyp-60, UBOX7, hCyP-60 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007627 23759 PPIL2 http://www.ncbi.nlm.nih.gov/gene/?term=23759 "CYC4, CYP60, Cyp-60, UBOX7, hCyP-60 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007628 23760 PITPNB http://www.ncbi.nlm.nih.gov/gene/?term=23760 "PI-TP-beta, PtdInsTP, VIB1B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007629 237611 Stac3 http://www.ncbi.nlm.nih.gov/gene/?term=237611 9.83E+24 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007630 23761 PISD http://www.ncbi.nlm.nih.gov/gene/?term=23761 "DJ858B16, PSD, PSDC, PSSC, dJ858B16.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007631 23762 OSBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23762 "HLM, ORP-4, ORP4, OSBPL1, OSBPL4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007632 23764 MAFF http://www.ncbi.nlm.nih.gov/gene/?term=23764 "U-MAF, hMafF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007633 23764 MAFF http://www.ncbi.nlm.nih.gov/gene/?term=23764 "U-MAF, hMafF " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007634 23764 MAFF http://www.ncbi.nlm.nih.gov/gene/?term=23764 "U-MAF, hMafF " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007635 23765 IL17RA http://www.ncbi.nlm.nih.gov/gene/?term=23765 "CANDF5, CD217, CDw217, IL-17RA, IL17R, hIL-17R " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007636 23768 FLRT2 http://www.ncbi.nlm.nih.gov/gene/?term=23768 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007637 23770 FKBP8 http://www.ncbi.nlm.nih.gov/gene/?term=23770 "FKBP38, FKBPr38 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007638 23770 FKBP8 http://www.ncbi.nlm.nih.gov/gene/?term=23770 "FKBP38, FKBPr38 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007639 237711 Eml6 http://www.ncbi.nlm.nih.gov/gene/?term=237711 "2900083P10Rik, C230094A16Rik, EMAP-6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007640 237730 Fbll1 http://www.ncbi.nlm.nih.gov/gene/?term=237730 AI595406 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007641 237782 Smcr8 http://www.ncbi.nlm.nih.gov/gene/?term=237782 "2310076G09Rik, AI642055, D030073L15Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007642 23780 APOL2 http://www.ncbi.nlm.nih.gov/gene/?term=23780 "APOL-II, APOL3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007643 23780 APOL2 http://www.ncbi.nlm.nih.gov/gene/?term=23780 "APOL-II, APOL3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007644 237823 Pfas http://www.ncbi.nlm.nih.gov/gene/?term=237823 "4432409B16Rik, FGAMS, FGAR-AT, FGARAT, Gm18, PURL, Sofa " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007645 23784 POTEH http://www.ncbi.nlm.nih.gov/gene/?term=23784 "A26C3, ACTBL1, CT104.7, POTE22 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007646 23784 POTEH http://www.ncbi.nlm.nih.gov/gene/?term=23784 "A26C3, ACTBL1, CT104.7, POTE22 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007647 237860 Ssh2 http://www.ncbi.nlm.nih.gov/gene/?term=237860 "SSH-2, SSH-2L, mSSH-2L " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007648 23786 BCL2L13 http://www.ncbi.nlm.nih.gov/gene/?term=23786 "BCL-RAMBO, Bcl2-L-13, MIL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007649 23787 MTCH1 http://www.ncbi.nlm.nih.gov/gene/?term=23787 "CGI-64, PIG60, PSAP, SLC25A49 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007650 23788 MTCH2 http://www.ncbi.nlm.nih.gov/gene/?term=23788 "HSPC032, MIMP, SLC25A50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007651 23788 MTCH2 http://www.ncbi.nlm.nih.gov/gene/?term=23788 "HSPC032, MIMP, SLC25A50 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007652 23790 Coro1c http://www.ncbi.nlm.nih.gov/gene/?term=23790 "AL022675, AW455561, AW548837 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007653 23792 Adam23 http://www.ncbi.nlm.nih.gov/gene/?term=23792 "AW046396, MDC3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007654 237940 Aoc2 http://www.ncbi.nlm.nih.gov/gene/?term=237940 RAO mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007655 237943 Gpatch8 http://www.ncbi.nlm.nih.gov/gene/?term=237943 "5430405G24Rik, AU018890, ENSMUSG00000075516, Fbm1, Gpatc8, mKIAA0553 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007656 23794 Adamts5 http://www.ncbi.nlm.nih.gov/gene/?term=23794 "9530092O11Rik, ADAM-TS5, ADAMTS1, ADAMTS11, AI481094, ASMP-2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007657 23796 Aplnr http://www.ncbi.nlm.nih.gov/gene/?term=23796 "APJ, Agtrl1, msr/apj " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007658 238023 Hexdc http://www.ncbi.nlm.nih.gov/gene/?term=238023 BC069960 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007659 238037 BC068281 http://www.ncbi.nlm.nih.gov/gene/?term=238037 A430092C04 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007660 23806 Arih1 http://www.ncbi.nlm.nih.gov/gene/?term=23806 "AU021774, Ari, Ari1, Hari, Hhari, Ubch7bp, Uip77 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007661 23808 Ash2l http://www.ncbi.nlm.nih.gov/gene/?term=23808 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007662 238130 Dock4 http://www.ncbi.nlm.nih.gov/gene/?term=238130 "5330406C03, 6330411N01Rik, AF263288, C030023J22, mKIAA0716 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007663 238130 Dock4 http://www.ncbi.nlm.nih.gov/gene/?term=238130 "5330406C03, 6330411N01Rik, AF263288, C030023J22, mKIAA0716 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007664 238252 Gpr135 http://www.ncbi.nlm.nih.gov/gene/?term=238252 PAFR mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007665 23825 Banf1 http://www.ncbi.nlm.nih.gov/gene/?term=23825 "Baf, Bcrp1, L2bp1/Baf " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007666 23830 Capn10 http://www.ncbi.nlm.nih.gov/gene/?term=23830 "AW049679, Capn8, mKIAA1845 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007667 23834 Cdc6 http://www.ncbi.nlm.nih.gov/gene/?term=23834 CDC18L mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007668 23837 Cfdp1 http://www.ncbi.nlm.nih.gov/gene/?term=23837 "AA408409, Bcnt, Bucentaur, Cfdp, cp27 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007669 238386 Btbd7 http://www.ncbi.nlm.nih.gov/gene/?term=238386 "5730507E09Rik, 8030448M07, E130118E17Rik, FUP1, mKIAA1525 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007670 23849 Klf6 http://www.ncbi.nlm.nih.gov/gene/?term=23849 "AI448727, BCD1, C86813, CPBP, Copeb, FM2, FM6, Ierepo1, Ierepo3, R75280, Zf9 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007671 23853 Def6 http://www.ncbi.nlm.nih.gov/gene/?term=23853 "2410003F05Rik, 6430538D02Rik, AV094905, Ibp, Slat, Slat2, Slat6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007672 23854 Def8 http://www.ncbi.nlm.nih.gov/gene/?term=23854 "AI449518, D8Ertd713e, DEF-8 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007673 23856 Dido1 http://www.ncbi.nlm.nih.gov/gene/?term=23856 "6720461J16Rik, D130048F08Rik, DATF-1, DIO-1, Datf1, dido " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007674 23857 Dmtf1 http://www.ncbi.nlm.nih.gov/gene/?term=23857 "Dimp, Dmp1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007675 23859 Dlg2 http://www.ncbi.nlm.nih.gov/gene/?term=23859 "A330103J02Rik, B230218P12Rik, B330007M19Rik, Dlgh2, Gm1197, PSD93 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007676 23859 Dlg2 http://www.ncbi.nlm.nih.gov/gene/?term=23859 "A330103J02Rik, B230218P12Rik, B330007M19Rik, Dlgh2, Gm1197, PSD93 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007677 238662 Spata31d1b http://www.ncbi.nlm.nih.gov/gene/?term=238662 "EG238662, Fam75d1b, Gm4934 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007678 238692 Zfp874a http://www.ncbi.nlm.nih.gov/gene/?term=238692 "C330011K17Rik, Rslcan15, Zfp874 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007679 238693 Zfp58 http://www.ncbi.nlm.nih.gov/gene/?term=238693 "A530094I17Rik, Mfg-1, Mfg1, Rslcan5, Zfp817 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007680 23877 Fiz1 http://www.ncbi.nlm.nih.gov/gene/?term=23877 "AI790204, mFLJ00416 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007681 23881 G3bp2 http://www.ncbi.nlm.nih.gov/gene/?term=23881 "AA409541, E430034L04Rik, G3BP, mKIAA0660 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007682 23885 Gmcl1 http://www.ncbi.nlm.nih.gov/gene/?term=23885 "2810049L19Rik, Gcl, mglc-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007683 238880 Actbl2 http://www.ncbi.nlm.nih.gov/gene/?term=238880 4732495G21Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007684 23894 Gtf2h2 http://www.ncbi.nlm.nih.gov/gene/?term=23894 "44kDa, BTF2 p44, BTF2-p44, Btf2p44, p44 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007685 238988 Erc2 http://www.ncbi.nlm.nih.gov/gene/?term=238988 "6430531D06, CAST, CAST1/ERC2, D14Ertd171e, ELKS2alpha " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007686 239037 Lrit1 http://www.ncbi.nlm.nih.gov/gene/?term=239037 "BC032270, Lrrc21 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007687 23918 Impdh2 http://www.ncbi.nlm.nih.gov/gene/?term=23918 IMPD mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00007688 23921 Sh2b2 http://www.ncbi.nlm.nih.gov/gene/?term=23921 Aps mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007689 23922 Jtb http://www.ncbi.nlm.nih.gov/gene/?term=23922 Gm622 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007690 23927 Krtap14 http://www.ncbi.nlm.nih.gov/gene/?term=23927 "AA589630, Pmg1, mKAP13 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007691 239318 Plcxd3 http://www.ncbi.nlm.nih.gov/gene/?term=239318 B130016O10Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007692 239393 Lrp12 http://www.ncbi.nlm.nih.gov/gene/?term=239393 "AI848829, C820005L12Rik, LRP-12 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007693 239408 Tmem74 http://www.ncbi.nlm.nih.gov/gene/?term=239408 "AA549547, B230382K22Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007694 23945 Mgll http://www.ncbi.nlm.nih.gov/gene/?term=23945 "AA589436, Magl, Mgl " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007695 23950 Dnajb6 http://www.ncbi.nlm.nih.gov/gene/?term=23950 "Mrj, mDj4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007696 239510 Phf20l1 http://www.ncbi.nlm.nih.gov/gene/?term=239510 "CGI-72, E130113K22Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007697 239528 Ago2 http://www.ncbi.nlm.nih.gov/gene/?term=239528 "1110029L17Rik, 2310051F07Rik, AI225898, AL022874, AW546247, ENSMUSG00000072493, Eif2c2, Gerp95, Gm10365, mKIAA4215 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007698 239528 Ago2 http://www.ncbi.nlm.nih.gov/gene/?term=239528 "1110029L17Rik, 2310051F07Rik, AI225898, AL022874, AW546247, ENSMUSG00000072493, Eif2c2, Gerp95, Gm10365, mKIAA4215 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007699 23955 Nek4 http://www.ncbi.nlm.nih.gov/gene/?term=23955 Stk2 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007700 2395 FXN http://www.ncbi.nlm.nih.gov/gene/?term=2395 "CyaY, FA, FARR, FRDA, X25 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007701 2395 FXN http://www.ncbi.nlm.nih.gov/gene/?term=2395 "CyaY, FA, FARR, FRDA, X25 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007702 23964 Tenm2 http://www.ncbi.nlm.nih.gov/gene/?term=23964 "Odz2, Odz3, Ten-2, Ten-m2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007703 23965 Tenm3 http://www.ncbi.nlm.nih.gov/gene/?term=23965 "2610100B16Rik, Odz1, Odz3, Ten-m3, mKIAA1455 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007704 23966 Tenm4 http://www.ncbi.nlm.nih.gov/gene/?term=23966 "Doc4, ELM2, Odz4, R75022, Ten-m4, l(7)-3Rn, l7Rn3, mKIAA1302 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007705 23966 Tenm4 http://www.ncbi.nlm.nih.gov/gene/?term=23966 "Doc4, ELM2, Odz4, R75022, Ten-m4, l(7)-3Rn, l7Rn3, mKIAA1302 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007706 23967 Osr1 http://www.ncbi.nlm.nih.gov/gene/?term=23967 "Odd1, Osr " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007707 239706 Mettl22 http://www.ncbi.nlm.nih.gov/gene/?term=239706 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007708 23970 Pacsin2 http://www.ncbi.nlm.nih.gov/gene/?term=23970 AI197433 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007709 239766 Rtp1 http://www.ncbi.nlm.nih.gov/gene/?term=239766 "Gm1766, Gm604 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007710 239833 Lmln http://www.ncbi.nlm.nih.gov/gene/?term=239833 "5330415H22Rik, AI465495 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007711 239857 Cadm2 http://www.ncbi.nlm.nih.gov/gene/?term=239857 "2900078E11Rik, 9330131D06, A830029E02Rik, Igdf4d, Igsf4d, NECL3, SynCAM 2, SynCAM2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007712 23985 Slc26a4 http://www.ncbi.nlm.nih.gov/gene/?term=23985 "Pds, pendrin " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007713 23999 Twf2 http://www.ncbi.nlm.nih.gov/gene/?term=23999 "A6-related, AU014993, Ptk9l, Ptk9r " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007714 239 ALOX12 http://www.ncbi.nlm.nih.gov/gene/?term=239 "12-LOX, 12S-LOX, LOG12 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007715 23 ABCF1 http://www.ncbi.nlm.nih.gov/gene/?term=23 "ABC27, ABC50 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007716 23 ABCF1 http://www.ncbi.nlm.nih.gov/gene/?term=23 "ABC27, ABC50 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007717 24001 Tiam2 http://www.ncbi.nlm.nih.gov/gene/?term=24001 "3000002F19Rik, STEF, mKIAA2016 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007718 240028 Lnpep http://www.ncbi.nlm.nih.gov/gene/?term=240028 "2010309L07Rik, 4732490P18Rik, CAP, IRAP, PLAP, gp160, vp165 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007719 240058 Cpne5 http://www.ncbi.nlm.nih.gov/gene/?term=240058 A830083G22Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007720 240064 Zfp799 http://www.ncbi.nlm.nih.gov/gene/?term=240064 6030490I01Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007721 240068 Zfp563 http://www.ncbi.nlm.nih.gov/gene/?term=240068 "D10628, D130054H01, NTfin7, Zfp413 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007722 24014 Rnasel http://www.ncbi.nlm.nih.gov/gene/?term=24014 E230029I04Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007723 24015 Abce1 http://www.ncbi.nlm.nih.gov/gene/?term=24015 "C79080, Oabp, RLI, RNS41, Rnaseli " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007724 24017 Rnf13 http://www.ncbi.nlm.nih.gov/gene/?term=24017 "2010001H16Rik, Rzf " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007725 24018 Rngtt http://www.ncbi.nlm.nih.gov/gene/?term=24018 "AU020997, HCE, MCE1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007726 240289 Gm4950 http://www.ncbi.nlm.nih.gov/gene/?term=240289 EG240289 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007727 24030 Mrps12 http://www.ncbi.nlm.nih.gov/gene/?term=24030 "AI327385, Rpms12, rps12 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007728 240427 Setbp1 http://www.ncbi.nlm.nih.gov/gene/?term=240427 "C130092E12, Seb, mKIAA0437 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007729 24050 Sept3 http://www.ncbi.nlm.nih.gov/gene/?term=24050 "3110018K01Rik, AV154067, B530002E20Rik, Sep3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007730 240514 Ccdc85b http://www.ncbi.nlm.nih.gov/gene/?term=240514 "AI842788, BB115872 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007731 24051 Sgcb http://www.ncbi.nlm.nih.gov/gene/?term=24051 "43kDa, AI747103, AI844814, beta-SG " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007732 24058 Sigirr http://www.ncbi.nlm.nih.gov/gene/?term=24058 "AI256711, TIR8 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007733 240590 Dmrt3 http://www.ncbi.nlm.nih.gov/gene/?term=240590 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007734 24060 Slc35a1 http://www.ncbi.nlm.nih.gov/gene/?term=24060 "AA408150, AI314851 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007735 24061 Smc1a http://www.ncbi.nlm.nih.gov/gene/?term=24061 "5830426I24Rik, SMC-1A, Sb1.8, Smc1lpha, Smc1l1, Smcb, mKIAA0178, Smc1a " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007736 24068 Sra1 http://www.ncbi.nlm.nih.gov/gene/?term=24068 "AA959952, Sra, Srap, Straa1, Strra1 " lncRNA Mus musculus 14517287 Nucleus HeLa cell In situ hybridization|qRT-PCR "In addition, in situ analysis traced SRA transcripts to the nuclei of the luminal epithelial cells of the mammary ducts (Fig. 2E, micrographs a to c) and the nuclei of the epithelial cells of the male accessory sex glands (micrographs d to f), showing an almost uniform expression pattern in the mammary glands and seminal vesicles. " RLID00007737 24068 Sra1 http://www.ncbi.nlm.nih.gov/gene/?term=24068 "AA959952, Sra, Srap, Straa1, Strra1 " lncRNA Mus musculus 25332394 Nucleus - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/sra/ RLID00007738 24068 Sra1 http://www.ncbi.nlm.nih.gov/gene/?term=24068 "AA959952, Sra, Srap, Straa1, Strra1 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00007739 24074 Taf7 http://www.ncbi.nlm.nih.gov/gene/?term=24074 "55kDa, AI607308, BB007175, TAFII55, Taf2f " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007740 240752 Pik3c2b http://www.ncbi.nlm.nih.gov/gene/?term=240752 "C330011J12Rik, Gm199, PI3K-C2beta, PI3KC2beta " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007741 240776 Kcnt2 http://www.ncbi.nlm.nih.gov/gene/?term=240776 "E330038N15Rik, Slick " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007742 240869 Zbtb37 http://www.ncbi.nlm.nih.gov/gene/?term=240869 D430004I08Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007743 24086 Tlk2 http://www.ncbi.nlm.nih.gov/gene/?term=24086 "4933403M19Rik, PKU-alpha, PKUalpha, Tlk " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007744 240899 Lrrc52 http://www.ncbi.nlm.nih.gov/gene/?term=240899 4930413P14Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007745 240899 Lrrc52 http://www.ncbi.nlm.nih.gov/gene/?term=240899 4930413P14Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007746 24099 Tnfsf13b http://www.ncbi.nlm.nih.gov/gene/?term=24099 "BAFF, BLyS, D8Ertd387e, TALL-1, TALL1, THANK, TNFSF20, Tnlg7a, zTNF4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007747 240 ALOX5 http://www.ncbi.nlm.nih.gov/gene/?term=240 "5-LO, 5-LOX, 5LPG, LOG5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007748 24105 Rbck1 http://www.ncbi.nlm.nih.gov/gene/?term=24105 "AL033326, HOIL-1, HOIL-1L, UIP28, Ubce7ip3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007749 241128 Fam124b http://www.ncbi.nlm.nih.gov/gene/?term=241128 A830043J08Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007750 24113 Vax2 http://www.ncbi.nlm.nih.gov/gene/?term=24113 Dres93 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007751 241263 Gpr158 http://www.ncbi.nlm.nih.gov/gene/?term=241263 "5330427M13Rik, mKIAA1136 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007752 24127 Xrn1 http://www.ncbi.nlm.nih.gov/gene/?term=24127 "Dhm2, exo, mXrn1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007753 24128 Xrn2 http://www.ncbi.nlm.nih.gov/gene/?term=24128 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007754 24135 Zfp68 http://www.ncbi.nlm.nih.gov/gene/?term=24135 "KRAB3, KRAZ2, Zfp70, mszf22, mszf49 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007755 24136 Zeb2 http://www.ncbi.nlm.nih.gov/gene/?term=24136 "9130203F04Rik, D130016B08Rik, SIP1, Zfhx1b, Zfx1b, Zfxh1b " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007756 241391 Galnt5 http://www.ncbi.nlm.nih.gov/gene/?term=241391 4832424J23 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007757 24139 EML2 http://www.ncbi.nlm.nih.gov/gene/?term=24139 "ELP70, EMAP-2, EMAP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007758 24140 FTSJ1 http://www.ncbi.nlm.nih.gov/gene/?term=24140 "CDLIV, JM23, MRX44, MRX9, SPB1, TRMT7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007759 241431 Xirp2 http://www.ncbi.nlm.nih.gov/gene/?term=241431 "2310003D02Rik, 2310008C07Rik, A530024P18Rik, AI452089, Cmya3, Gm352, Xin2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007760 24144 TFIP11 http://www.ncbi.nlm.nih.gov/gene/?term=24144 "NTR1, Spp382, TIP39, bK445C9.6, hNtr1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007761 24144 TFIP11 http://www.ncbi.nlm.nih.gov/gene/?term=24144 "NTR1, Spp382, TIP39, bK445C9.6, hNtr1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007762 24145 PANX1 http://www.ncbi.nlm.nih.gov/gene/?term=24145 "MRS1, PX1, UNQ2529 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007763 24145 PANX1 http://www.ncbi.nlm.nih.gov/gene/?term=24145 "MRS1, PX1, UNQ2529 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007764 24147 FJX1 http://www.ncbi.nlm.nih.gov/gene/?term=24147 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007765 24148 PRPF6 http://www.ncbi.nlm.nih.gov/gene/?term=24148 "ANT-1, ANT1, C20orf14, Prp6, RP60, SNRNP102, TOM, U5-102K, hPrp6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007766 24148 PRPF6 http://www.ncbi.nlm.nih.gov/gene/?term=24148 "ANT-1, ANT1, C20orf14, Prp6, RP60, SNRNP102, TOM, U5-102K, hPrp6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007767 241490 Rbm45 http://www.ncbi.nlm.nih.gov/gene/?term=241490 "Drb1, Drbp1, G430095G15Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007768 24149 ZNF318 http://www.ncbi.nlm.nih.gov/gene/?term=24149 "HRIHFB2436, TZF, ZFP318 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007769 241514 Zfp804a http://www.ncbi.nlm.nih.gov/gene/?term=241514 "C630007C17Rik, Znf804a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007770 241547 Harbi1 http://www.ncbi.nlm.nih.gov/gene/?term=241547 D230010M03Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007771 241556 Tspan18 http://www.ncbi.nlm.nih.gov/gene/?term=241556 "2610042G18Rik, 6720430O15, BB226562 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007772 241627 Wdr76 http://www.ncbi.nlm.nih.gov/gene/?term=241627 "5830411K18Rik, 6030457D09, AA517836 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007773 24186 Alb http://www.ncbi.nlm.nih.gov/gene/?term=24186 "Alb1za, Alb " mRNA Rattus norvegicus 3301049 Endoplasmic reticulum Liver In situ hybridization "When examined at the ultrastructural level, albumin was localized in the rough endoplasmic reticulum as well as in Golgi complexes located near the nucleus in nearly all these hepatocytes. " RLID00007774 24186 Alb http://www.ncbi.nlm.nih.gov/gene/?term=24186 "Alb1za, Alb " mRNA Rattus norvegicus 3301049 Golgi apparatus Liver In situ hybridization "When examined at the ultrastructural level, albumin was localized in the rough endoplasmic reticulum as well as in Golgi complexes located near the nucleus in nearly all these hepatocytes. " RLID00007775 24186 Alb http://www.ncbi.nlm.nih.gov/gene/?term=24186 "Alb1za, Alb " mRNA Rattus norvegicus 2405055 Cytoplasm Liver In situ hybridization "In normal rat liver, alb mRNA was expressed in all hepatocytes and was localized to discrete subcellular structures distributed as aggregates in the cytoplasm and in specific structures encircling the nucleus; these subcellular structures most likely represent the endoplasmic reticulum and nuclear envelope. " RLID00007776 24186 Alb http://www.ncbi.nlm.nih.gov/gene/?term=24186 "Alb1za, Alb " mRNA Rattus norvegicus 2405055 Endoplasmic reticulum Liver In situ hybridization "In normal rat liver, alb mRNA was expressed in all hepatocytes and was localized to discrete subcellular structures distributed as aggregates in the cytoplasm and in specific structures encircling the nucleus; these subcellular structures most likely represent the endoplasmic reticulum and nuclear envelope. " RLID00007777 24186 Alb http://www.ncbi.nlm.nih.gov/gene/?term=24186 "Alb1za, Alb " mRNA Rattus norvegicus 2405055 Nucleus Liver In situ hybridization "In normal rat liver, alb mRNA was expressed in all hepatocytes and was localized to discrete subcellular structures distributed as aggregates in the cytoplasm and in specific structures encircling the nucleus; these subcellular structures most likely represent the endoplasmic reticulum and nuclear envelope. Figure 3. In situ hybridization for albumin mRNA using aldehyde-fixed non-frozen sactions of rat liver, biotin-1 1-UTP anti-sense albumin RNA (riboprobe), and streptavidin-alkaline phosphatase detection system. (a, b) Biotinylated anti-sense alb RNA (riboprobe);(c)sense alb ANYcontrol probe. PT, portal triad; CV, central vein; N, nucleus. Albumin mANA is seen only in hepatocytes (a, b) and is shown as a diffuse cytoplasmic stain (arrows). " RLID00007778 24191 Aldoc http://www.ncbi.nlm.nih.gov/gene/?term=24191 "ALDCAA, F16dip7, RATALDCAA " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00007779 241944 D3Ertd254e http://www.ncbi.nlm.nih.gov/gene/?term=241944 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007780 242083 Ppm1l http://www.ncbi.nlm.nih.gov/gene/?term=242083 "3222401G13, 5930404J21Rik, AI481720, AW045850, PP2C, PP2Cepsilon, Pp2ce, Ppp2ce, mKIAA4175 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007781 24221 Avp http://www.ncbi.nlm.nih.gov/gene/?term=24221 "DI, VP, Vas " mRNA Rattus norvegicus 7753814 Axon Hypothalamus In situ hybridization "In contrast, wild-type and mutant AVP mRNAs are present in dendrites. It will be demonstrated that in heterozygous BB rats, which express both alleles of the AVP gene, only the wild-type mRNA is subject to axonal compartmentation, whereas wild-type and mutant mRNAs are directed to dendrites of Hypothalamic magnocellular Neurons. " RLID00007782 24221 Avp http://www.ncbi.nlm.nih.gov/gene/?term=24221 "DI, VP, Vas " mRNA Rattus norvegicus 7753814 Dendrite Hypothalamus In situ hybridization "In contrast, wild-type and mutant AVP mRNAs are present in dendrites. It will be demonstrated that in heterozygous BB rats, which express both alleles of the AVP gene, only the wild-type mRNA is subject to axonal compartmentation, whereas wild-type and mutant mRNAs are directed to dendrites of Hypothalamic magnocellular Neurons. " RLID00007783 24221 Avp http://www.ncbi.nlm.nih.gov/gene/?term=24221 "DI, VP, Vas " mRNA Rattus norvegicus 8283246 Dendrite Neuron In situ hybridization "When vasopressin mRNA was detected in medium-size dendrites, it was always associated with the rough endoplasmic reticulum (RER). " RLID00007784 24221 Avp http://www.ncbi.nlm.nih.gov/gene/?term=24221 "DI, VP, Vas " mRNA Rattus norvegicus 8283246 Endoplasmic reticulum Neuron In situ hybridization "Within the labeled magnocellular perikarya, the abundant vasopressin mRNA was mainly associated with discrete areas of the RER. These data suggest that vasopressin mRNA translation is restricted to certain segments within the RER, and that axonal transport of vasopressin mRNA does not involve the classical neurosecretory pathway, via the Golgi apparatus and the neurosecretory granules, as has been proposed. " RLID00007785 24221 Avp http://www.ncbi.nlm.nih.gov/gene/?term=24221 "DI, VP, Vas " mRNA Rattus norvegicus 8812056 Endoplasmic reticulum Hypothalamus In situ hybridization "Altogether, these ultrastructural studies strongly suggested that the Gas and AVP mRNAs might be associated with distinct domains of the RER. " RLID00007786 24221 Avp http://www.ncbi.nlm.nih.gov/gene/?term=24221 "DI, VP, Vas " mRNA Rattus norvegicus 9104594 Dendrite Hypothalamus In situ hybridization "As revealed by in situ hybridization at the electron microscopic level, the mRNA is located in proximal and distal dendritic segments and is exclusively confined to regions containing rough endoplasmic reticulum. The data reported here confirm the presence of VP mRNA in proximal and distal segments of dendrites. Sections taken from the ventral glial lamina revealed the dendritic compartmentalization of VP mRNA. " RLID00007787 24221 Avp http://www.ncbi.nlm.nih.gov/gene/?term=24221 "DI, VP, Vas " mRNA Rattus norvegicus 12106310 Cytoplasm Neuron Northern blot "Most likely, vasopressin transcripts are absent from the nerve terminals as a consequence of the impaired precursor biosynthesis in the cytoplasm of the mutant rat. " RLID00007788 24221 Avp http://www.ncbi.nlm.nih.gov/gene/?term=24221 "DI, VP, Vas " mRNA Rattus norvegicus 12814355 Cytoplasm Neuron In situ hybridization "Furthermore, galanin and vasopressin messenger RNAs were detected at different domains of the endoplasmic reticulum, suggesting that translation might also occur at different locations, thus leading to partial segregation of galanin and vasopressin cargoes between two populations of secretory granules. In contrast, galanin mRNA was detected in a perinuclear area and in patches scattered in peripheral cytoplasm. In processes, vasopressin mRNA signal was clearly detected(Fig.1B) but labelling remained weak for galanin mRNA. " RLID00007789 24221 Avp http://www.ncbi.nlm.nih.gov/gene/?term=24221 "DI, VP, Vas " mRNA Rattus norvegicus 12814355 Endoplasmic reticulum Neuron In situ hybridization "Furthermore, galanin and vasopressin messenger RNAs were detected at different domains of the endoplasmic reticulum, suggesting that translation might also occur at different locations, thus leading to partial segregation of galanin and vasopressin cargoes between two populations of secretory granules. In contrast, galanin mRNA was detected in a perinuclear area and in patches scattered in peripheral cytoplasm. In processes, vasopressin mRNA signal was clearly detected(Fig.1B) but labelling remained weak for galanin mRNA. " RLID00007790 24221 Avp http://www.ncbi.nlm.nih.gov/gene/?term=24221 "DI, VP, Vas " mRNA Rattus norvegicus 8283246 Axon Neuron In situ hybridization "Within the magnocellular neuron axons, vasopressin mRNA could be detected only in a subset of axonal swellings, all of which were confined to the internal layer of the ME and the PP. vasopressin mRNA could be detected only in a subset of axonal swellings, " RLID00007791 24225 Bdnf http://www.ncbi.nlm.nih.gov/gene/?term=24225 mRNA Rattus norvegicus 12121312 Dendrite Hippocampus In situ hybridization "Nonstimulated rats: BDNF, TrkB, and CaMKII-β mRNAs localized in the soma and in the proximal dendrites of hippocampal pyramidal cells, and in the soma only of dentate gyrus (DG) granule cells; CaMKII-α mRNA localized throughout the dendritic length in neurons of all hippocampal subfields. In contrast, CaMKII-α (Figs. 1C and 2D), BDNF (Figs. 1E and 2G), and TrkB mRNAs (Figs.1G and 2J) were localized in the soma and in the proximal dendrites of hippocampal pyramidal cells, and in the soma only of DG granule cells. " RLID00007792 24225 Bdnf http://www.ncbi.nlm.nih.gov/gene/?term=24225 mRNA Rattus norvegicus 12121312 Dendrite Hippocampus In situ hybridization "Pilocarpine seizures: increased staining levels of CaMKII-β mRNA throughout the whole dendritic length in all hippocampal subfields; induction of CaMKII-α, BDNF, and TrkB mRNAs dendritic targeting in CA1, CA3, and DG neurons. Data provide evidence that BDNF, TrkB, and CaMKII-α and -β mRNAs are accumulated in the dendrites of specific hippocampal neurons during pilocarpine seizures and kindling development. " RLID00007793 24225 Bdnf http://www.ncbi.nlm.nih.gov/gene/?term=24225 mRNA Rattus norvegicus 15282290 Dendrite Hippocampus In situ hybridization "In untreated rats (n = 10) (Fig. 1, control), BDNF mRNA was present in the soma and the proximal dendritic compartment of CA1 and CA3 pyramidal neurons (up to ?50-70 ?m from the cell body) (Fig. 2A, arrowheads), whereas in dentate gyrus granule cells, labeling was present in the soma only. " RLID00007794 24225 Bdnf http://www.ncbi.nlm.nih.gov/gene/?term=24225 mRNA Rattus norvegicus 16388108 Dendrite Neuron In situ hybridization "Strong depolarizing stimuli, both in vitro and in vivo, elicit accumulation of BDNF mRNA and protein in the distal dendrites through a signaling pathway involving the activation of the N-methyl-D-aspartate and tyrosine kinase B receptors and an intracellular increase in Ca2+ concentration " RLID00007795 24225 Bdnf http://www.ncbi.nlm.nih.gov/gene/?term=24225 mRNA Rattus norvegicus 18497100 Dendrite Hippocampus In situ hybridization "The first clear evidence that BDNF and TrkB mRNAs are located in dendrites was found in primary cultures of rat hippocampal neurons where, under basal conditions, these two mRNAs are localized in the initial dendritic compartment (an average of 31.5m from the cell soma considering all types of dendrites and within a range of 30-100m from the cell soma, when considering apical dendrites only). " RLID00007796 24225 Bdnf http://www.ncbi.nlm.nih.gov/gene/?term=24225 mRNA Rattus norvegicus 26578876 Dendrite Hippocampus RNAi Interference|Clip "We found that dendritic localization of BDNF mRNAs with short 3' UTR was induced by depolarization and NT3 in vitro or by seizures in vivo and required CPEB-1, -2 and ELAV-2, -4. " RLID00007797 24225 Bdnf http://www.ncbi.nlm.nih.gov/gene/?term=24225 mRNA Rattus norvegicus 26700412 Dendrite Hippocampus RT-PCR "BDNF mRNA is transported to dendritic and axons,where it is expressed locally. BDNF mRNA is not only translated in the cell body but is also transported to dendrites. " RLID00007798 24225 Bdnf http://www.ncbi.nlm.nih.gov/gene/?term=24225 mRNA Rattus norvegicus 26700412 Axon Hippocampus RT-PCR "BDNF mRNA is transported to dendritic and axons,where it is expressed locally. BDNF mRNA is not only translated in the cell body but is also transported to dendrites. " RLID00007799 24225 Bdnf http://www.ncbi.nlm.nih.gov/gene/?term=24225 mRNA Rattus norvegicus 26700412 Cell body Hippocampus RT-PCR "BDNF mRNA is transported to dendritic and axons,where it is expressed locally. BDNF mRNA is not only translated in the cell body but is also transported to dendrites. " RLID00007800 242291 Impad1 http://www.ncbi.nlm.nih.gov/gene/?term=242291 "1110001C20Rik, AA408880, AI451589, AL022796, B230207P20, Jaws, gPAPP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007801 242291 Impad1 http://www.ncbi.nlm.nih.gov/gene/?term=242291 "1110001C20Rik, AA408880, AI451589, AL022796, B230207P20, Jaws, gPAPP " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007802 24241 Calca http://www.ncbi.nlm.nih.gov/gene/?term=24241 "CAL6, CGRP, Cal1, Calc, RATCAL6, calcitonin " mRNA Rattus norvegicus 19225405 Axon Peripheral nerve RT-PCR|Fluorescence in situ hybridization "Intense peptide expression accompanied local rises in alphaCGRP mRNA in the nerve trunk, and there was evidence of transport of alphaCGRP mRNA into regenerating axons, indicating intra-axonal peptide synthesis. " RLID00007803 242466 Zfp462 http://www.ncbi.nlm.nih.gov/gene/?term=242466 "6030417H05, 9430078C22Rik, Gt4-2, Zfpip " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007804 242474 Tmem245 http://www.ncbi.nlm.nih.gov/gene/?term=242474 "A630051L19Rik, AI957324, D730040F13Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007805 242509 Bnc2 http://www.ncbi.nlm.nih.gov/gene/?term=242509 "5031434M05Rik, 8430420F16Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007806 242585 Slc35d1 http://www.ncbi.nlm.nih.gov/gene/?term=242585 "AI834976, C330011J09, UGTREL7, mKIAA0260 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007807 242608 Podn http://www.ncbi.nlm.nih.gov/gene/?term=242608 "9430070G18, Pcan, SLRR5A " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007808 242662 Rims3 http://www.ncbi.nlm.nih.gov/gene/?term=242662 "A730060M23Rik, Nim3, Rim3, mKIAA0237 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007809 242669 Azin2 http://www.ncbi.nlm.nih.gov/gene/?term=242669 "4933429I20Rik, Adc, Azi2, B930082O19, ODC-p, Odcp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007810 242726 Padi6 http://www.ncbi.nlm.nih.gov/gene/?term=242726 "Pad6, Padi5, ePAD " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007811 242860 Rsbn1l http://www.ncbi.nlm.nih.gov/gene/?term=242860 "8430412F05Rik, AI447441, C330002G24Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007812 242915 Gareml http://www.ncbi.nlm.nih.gov/gene/?term=242915 "Fam59b, Garem2, Gm444 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007813 24316 Drd1 http://www.ncbi.nlm.nih.gov/gene/?term=24316 "D1a, Drd-1a, Drd1 " mRNA Rattus norvegicus 9541476 Perinuclear Brain In situ hybridization D1 mRNA was localized to perikarya but not to dendrites or axons. RLID00007814 243219 2900026A02Rik http://www.ncbi.nlm.nih.gov/gene/?term=243219 "8430408O14Rik, A530094D01, AW539426, Gm449, Kiaa1671, mKIAA1671 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007815 243308 A430033K04Rik http://www.ncbi.nlm.nih.gov/gene/?term=243308 C86988 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007816 24333 Eno1 http://www.ncbi.nlm.nih.gov/gene/?term=24333 Nne mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00007817 24334 Eno2 http://www.ncbi.nlm.nih.gov/gene/?term=24334 "NSE, RNEN3 " mRNA Rattus norvegicus 12106310 Axon Neuron Northern blot "To determine whether NSE mRNA, detected in the stalk region, is present in axons, RNAs were subsequently analysed for primary gene transcripts by amplifying an intronic sequence. This could clearly be detected in the neural stalk (Fig. lc), indicating NSE gene expression in cells of the hypophyseal stalk. The presence of NSE primary transcripts in the neural lobe (Fig. lc) is most likely due to the expression of this gene in intermediate lobe cells. " RLID00007818 24334 Eno2 http://www.ncbi.nlm.nih.gov/gene/?term=24334 "NSE, RNEN3 " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00007819 243499 Lrrtm4 http://www.ncbi.nlm.nih.gov/gene/?term=243499 "7530419J18Rik, A230052N11 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007820 243548 Prickle2 http://www.ncbi.nlm.nih.gov/gene/?term=243548 "6230400G14Rik, 6720451F06Rik, mpk2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007821 243653 Clec1a http://www.ncbi.nlm.nih.gov/gene/?term=243653 5930406N14Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007822 243822 Fam71e2 http://www.ncbi.nlm.nih.gov/gene/?term=243822 4930401F20Rik mRNA Mus musculus 26071953 Nucleus Sperm RT-PCR "Within this set of RNAs, the Prm1 transcript, as well as Erich2 and Fam71e2 (formerly 4933404M02Rik and 4930401F20Rik, respectively), were previously identified within the mouse sperm nucleus by RT-PCR though their preferential localization within the gamete could not be inferred from that study (15). " RLID00007823 24383 Gapdh http://www.ncbi.nlm.nih.gov/gene/?term=24383 "BARS-38, Gapd " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00007824 243846 Ccdc9 http://www.ncbi.nlm.nih.gov/gene/?term=243846 2600011L02Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007825 243874 Nlrp9b http://www.ncbi.nlm.nih.gov/gene/?term=243874 "Nalp-delta, Nalp9b, Nlrp9 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007826 243905 Zfp568 http://www.ncbi.nlm.nih.gov/gene/?term=243905 "C80731, Gm1691, chato " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007827 243912 Hspb6 http://www.ncbi.nlm.nih.gov/gene/?term=243912 "AA387366, Gm479, Hsp20 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007828 24391 Gh1 http://www.ncbi.nlm.nih.gov/gene/?term=24391 "Gh, Ghb1, RNGHGP " mRNA Rattus norvegicus 16691013 Axon Retina In situ hybridization "Fig. 5. In situ hybridization of GH mRNA in the neural retina of newborn rats. (A) Specific hybridization with a 693- bp DIG-labeled BamH1 antisense probe for GH mRNA is shown throughout the neural retina, particularly in large, rounded cells in the RGC layer of the inner retina. Magnification,x40. (B) Magnification, x100. (C) Magnification, x400. (D) Magnification, x1000. Labeling to a large ganglion cell and its axon (green arrow) is shown. (E) The neural retina is not labeled in the presence of a Not1 DIG-labeled sense probe. Magnification, x40. Representative of similar data from at least three rats. " RLID00007829 24391 Gh1 http://www.ncbi.nlm.nih.gov/gene/?term=24391 "Gh, Ghb1, RNGHGP " mRNA Rattus norvegicus 1607645 Endoplasmic reticulum Pituitary gland In situ hybridization "With the purpose of comparing the sensitivity, resolution, and ultrastructural preservation of these three methods, we examined the expression of the growth hormone (GH) gene in anterior pituitary cells by in situ hybridization at the ultrastructural level, using a synthetic oligonucleotide complementary to the codons of the mRNA from Gln 45 to Ser 54 labeled at the 3' end of biotin-21dUTP. All these methods gave similar results: mRNA was located on the lamellar endoplasmic reticulum of somatotrophs. " RLID00007830 24391 Gh1 http://www.ncbi.nlm.nih.gov/gene/?term=24391 "Gh, Ghb1, RNGHGP " mRNA Rattus norvegicus 7843989 Ribosome Pituitary cell In situ hybridization "Preembedding electron microscopic ISH localized rat growth hormone and prolactin mRNAs on the polysomes of the rough endoplasmic reticulum (RER). Rat growth hormone mRNA was distributed diffusely on the RER, whereas rat prolactin mRNA was scattered and distributed focally. Thus there might be a specific translational site for prolactin mRNA on the RER. Rat growth hormone mRNA signals were also recognized on the polysomes of the RER, using the postembedding method with streptavidin gold conjugate. " RLID00007831 24391 Gh1 http://www.ncbi.nlm.nih.gov/gene/?term=24391 "Gh, Ghb1, RNGHGP " mRNA Rattus norvegicus 7843989 Endoplasmic reticulum Pituitary cell In situ hybridization "Preembedding electron microscopic ISH localized rat growth hormone and prolactin mRNAs on the polysomes of the rough endoplasmic reticulum (RER). Rat growth hormone mRNA was distributed diffusely on the RER, whereas rat prolactin mRNA was scattered and distributed focally. Thus there might be a specific translational site for prolactin mRNA on the RER. Rat growth hormone mRNA signals were also recognized on the polysomes of the RER, using the postembedding method with streptavidin gold conjugate. " RLID00007832 243937 Zfp536 http://www.ncbi.nlm.nih.gov/gene/?term=243937 "9630010P11Rik, Znf536, mKIAA0390 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007833 243983 Zdhhc13 http://www.ncbi.nlm.nih.gov/gene/?term=243983 "2410004E01Rik, C530010M18, HIP3RP, Hip14l, kojak, skc4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007834 244049 Mctp2 http://www.ncbi.nlm.nih.gov/gene/?term=244049 Gm489 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007835 244059 Chd2 http://www.ncbi.nlm.nih.gov/gene/?term=244059 "2810013C04Rik, 2810040A01Rik, 5630401D06Rik, AI851092, BC029703, CHD-2 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007836 244059 Chd2 http://www.ncbi.nlm.nih.gov/gene/?term=244059 "2810013C04Rik, 2810040A01Rik, 5630401D06Rik, AI851092, BC029703, CHD-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007837 24409 Grin2a http://www.ncbi.nlm.nih.gov/gene/?term=24409 "GluN2A, NMDAR2A, NR2A " mRNA Rattus norvegicus 23678131 Dendrite Hippocampus Fluorescence in situ hybridization Dendra2 fluorescence levels were significantly increased at 25 min after glycine application and reached a plateau by 40 min. These data suggest that glycine treatment induces the local translation of GluN2A mRNA in dendrites.Dendra2 fluorescence levels were significantly increased at 25 min after glycine application and reached a plateau by 40 min. These data suggest that glycine treatment induces the local translation of GluN2A mRNA in dendrites. RLID00007838 244141 Nars2 http://www.ncbi.nlm.nih.gov/gene/?term=244141 AI875199 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007839 244141 Nars2 http://www.ncbi.nlm.nih.gov/gene/?term=244141 AI875199 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007840 244216 Zfp771 http://www.ncbi.nlm.nih.gov/gene/?term=244216 "G630024C07Rik, Znf771 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007841 244219 Zfp668 http://www.ncbi.nlm.nih.gov/gene/?term=244219 "BC030314, E130018B19Rik, Znf668 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007842 244329 Mcph1 http://www.ncbi.nlm.nih.gov/gene/?term=244329 "5430437K10Rik, BRIT1, D030046N04Rik, MCT " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007843 244334 Defb8 http://www.ncbi.nlm.nih.gov/gene/?term=244334 "BD-8, Defr1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007844 244373 Erlin2 http://www.ncbi.nlm.nih.gov/gene/?term=244373 "BC036333, C87251, Spfh2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007845 244418 D8Ertd82e http://www.ncbi.nlm.nih.gov/gene/?term=244418 "9830148H23, NACK, Sgk223, mFLJ00269 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007846 244421 Lonrf1 http://www.ncbi.nlm.nih.gov/gene/?term=244421 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007847 244448 Triml1 http://www.ncbi.nlm.nih.gov/gene/?term=244448 "4933403D14, BC050188 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007848 244654 Mtss1l http://www.ncbi.nlm.nih.gov/gene/?term=244654 ABBA mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007849 244667 Disc1 http://www.ncbi.nlm.nih.gov/gene/?term=244667 mRNA Mus musculus 25821909 Dendrite Neuron Fluorescence in situ hybridization "DISC1 colocalizes with HZF and ITPR1 mRNA in hippocampal dendrites and directly associates with neuronal mRNAs, including ITPR1 mRNA. DISC1 colocalized with HZF and Itpr1 mRNA in hippocampal dendrites. " RLID00007850 244713 Zfp317 http://www.ncbi.nlm.nih.gov/gene/?term=244713 "4932416G03, D230022C05Rik, KRAB9, Zfp67, Zfp75, mszf40 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007851 24471 Hspb1 http://www.ncbi.nlm.nih.gov/gene/?term=24471 "Hsp25, Hsp27 " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00007852 24471 Hspb1 http://www.ncbi.nlm.nih.gov/gene/?term=24471 "Hsp25, Hsp27 " mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00007853 244864 Layn http://www.ncbi.nlm.nih.gov/gene/?term=244864 "E030012M19Rik, Gm511 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007854 244879 Npat http://www.ncbi.nlm.nih.gov/gene/?term=244879 "6820401K01, AI427561, BB112559 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007855 244891 Scaper http://www.ncbi.nlm.nih.gov/gene/?term=244891 "C430017I08, D530014O03Rik, Zfp291 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007856 244962 Snx14 http://www.ncbi.nlm.nih.gov/gene/?term=244962 "B830022K16, C330035N22Rik, YR-14 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007857 245000 Atr http://www.ncbi.nlm.nih.gov/gene/?term=245000 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007858 245109 Zscan4c http://www.ncbi.nlm.nih.gov/gene/?term=245109 "Gm397, XM_142517, Zscan4d " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007859 245381 Sowahd http://www.ncbi.nlm.nih.gov/gene/?term=245381 "A630014H24Rik, Ankrd58 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007860 245474 Dkc1 http://www.ncbi.nlm.nih.gov/gene/?term=245474 BC068171 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007861 24547 Mbp http://www.ncbi.nlm.nih.gov/gene/?term=24547 Mbps mRNA Rattus norvegicus 7877439 Cytoplasm Oligodendrocytes In situ hybridization MBP mRNA was confined to the perinuclear cytoplasm of immature oligodendrocytes and was then transported into the myelin sheath at a developmental stage corresponding to myelination. RLID00007862 245509 4932429P05Rik http://www.ncbi.nlm.nih.gov/gene/?term=245509 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007863 245555 C77370 http://www.ncbi.nlm.nih.gov/gene/?term=245555 "A230051P11, C77386, Kiaa2022, Xpn, mKIAA2022 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007864 245598 4921511C20Rik http://www.ncbi.nlm.nih.gov/gene/?term=245598 Gm383 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007865 245610 Nxf3 http://www.ncbi.nlm.nih.gov/gene/?term=245610 Gm384 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007866 24564 Mpz http://www.ncbi.nlm.nih.gov/gene/?term=24564 "MPP, P0 " mRNA Rattus norvegicus 1706417 Endoplasmic reticulum Schwann cell In situ hybridization "In sections of ganglia from 2-day-old rats, studied by light and electron microscopy, peroxidase reaction product localizing hybridized P0 mRNA was found on profiles of granular (rough) endoplasmic reticulum (RER) in perinuclear regions of Schwann cells which had formed two to three compact myelin lamellae. " RLID00007867 245666 Iqsec2 http://www.ncbi.nlm.nih.gov/gene/?term=245666 Brag1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007868 245812 CNPY4 http://www.ncbi.nlm.nih.gov/gene/?term=245812 PRAT4B mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007869 245828 Trappc1 http://www.ncbi.nlm.nih.gov/gene/?term=245828 "BET5, D11Ertd172e, MUM2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007870 245847 Amdhd2 http://www.ncbi.nlm.nih.gov/gene/?term=245847 5730457F11Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007871 24586 Ncam1 http://www.ncbi.nlm.nih.gov/gene/?term=24586 "Cd56, N-CAM, N-CAM-1, NCAM-1, NCAM-C, NCAMC, Ncam " mRNA Rattus norvegicus 7599960 Synapse Muscle fibers In situ hybridization "N-CAM, 43K-rapsyn, and S-laminin mRNAs are concentrated at synaptic sites in muscle fibers " RLID00007872 24591 Neu1 http://www.ncbi.nlm.nih.gov/gene/?term=24591 mRNA Rattus norvegicus 12213446 Dendrite Brain In situ hybridization The most interesting observation regarding neu1 mRNA localization in the adult brain was the clear dendritic localization of the transcripts in the hippocampus. RLID00007873 24596 Ngfr http://www.ncbi.nlm.nih.gov/gene/?term=24596 "LNGFR, RNNGFRR, Tnfrsf16, p75, p75NTR " mRNA Rattus norvegicus 11043561 Dendrite ForeBrain In situ hybridization "We find that TrkA, TrkC and p75 mRNAs are restricted to the cell soma but in addition, p75 mRNA labelling extends in average for 8 um within the proximal dendrites of 34% of the labelled neurons. The in situ staining for p75 mRNA, was generally restricted to the cell soma but in some neurons the staining was present in the proximal portion of the dendrites of the septum (Fig. 1h, arrows) and diagonal band (not shown) but not of the caudateputamen (Fig. 1i). " RLID00007874 245972 ATP6V0D2 http://www.ncbi.nlm.nih.gov/gene/?term=245972 "ATP6D2, VMA6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007875 245972 ATP6V0D2 http://www.ncbi.nlm.nih.gov/gene/?term=245972 "ATP6D2, VMA6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007876 245972 ATP6V0D2 http://www.ncbi.nlm.nih.gov/gene/?term=245972 "ATP6D2, VMA6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007877 245973 ATP6V1C2 http://www.ncbi.nlm.nih.gov/gene/?term=245973 "ATP6C2, VMA5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007878 24598 Nos1 http://www.ncbi.nlm.nih.gov/gene/?term=24598 bNOS mRNA Rattus norvegicus 9351678 Cell body Neuron In situ hybridization Here we show mRNA expression of NOS type-1 (neuronal or brain NOS) transcripts in cell bodies of sympathetic preganglionic neurons (SPNs) of the intermediolateral (IML) cell column by non-radioactive in situ hybridization using NOS-I riboprobes. RLID00007879 24599 Nos2 http://www.ncbi.nlm.nih.gov/gene/?term=24599 "Nos2a, iNos " mRNA Rattus norvegicus 9290578 Cytoplasm Vascular endothelial cell In situ hybridization "After endotoxin administration, iNOS mRNA was localized in the cytoplasm of vascular endothelial cells, vascular smooth muscle cells and cardiomyocytes (Figure 4). " RLID00007880 246048 Chodl http://www.ncbi.nlm.nih.gov/gene/?term=246048 "3110074E07Rik, MT75, PRED12 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007881 246118 Tubb3 http://www.ncbi.nlm.nih.gov/gene/?term=246118 mRNA Rattus norvegicus 21098654 Axon Embryo RT-PCR "Tubulin-beta3 (Tubb3) mRNA is present only in embryonic axons, with Tubb3 locally synthesized in axons of embryonic, but not adult neurons where it is transported " RLID00007882 246175 CNOT6L http://www.ncbi.nlm.nih.gov/gene/?term=246175 CCR4b mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007883 246184 CDC26 http://www.ncbi.nlm.nih.gov/gene/?term=246184 "ANAPC12, APC12, C9orf17 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007884 246184 CDC26 http://www.ncbi.nlm.nih.gov/gene/?term=246184 "ANAPC12, APC12, C9orf17 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007885 246221 Mpst http://www.ncbi.nlm.nih.gov/gene/?term=246221 Mst mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007886 246243 RNASEH1 http://www.ncbi.nlm.nih.gov/gene/?term=246243 "H1RNA, PEOB2, RNH1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007887 246243 RNASEH1 http://www.ncbi.nlm.nih.gov/gene/?term=246243 "H1RNA, PEOB2, RNH1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007888 246243 RNASEH1 http://www.ncbi.nlm.nih.gov/gene/?term=246243 "H1RNA, PEOB2, RNH1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007889 246274 Faim2 http://www.ncbi.nlm.nih.gov/gene/?term=246274 "Lfg, NMP35 " mRNA Rattus norvegicus 23966695 Axon Sensory neuron RT-PCR We recently reported that neural membrane protein 35 (NMP35) mRNA is transported into axons through its 3'UTR RLID00007890 246274 Faim2 http://www.ncbi.nlm.nih.gov/gene/?term=246274 "Lfg, NMP35 " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00007891 246313 Prokr2 http://www.ncbi.nlm.nih.gov/gene/?term=246313 "B830005M06Rik, EG-VEGRF2, Gpcr73l1, Gpr73l1, PKR2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007892 246330 PELI3 http://www.ncbi.nlm.nih.gov/gene/?term=246330 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007893 24644 Pgk1 http://www.ncbi.nlm.nih.gov/gene/?term=24644 Pgk mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00007894 246534 CG30291 http://www.ncbi.nlm.nih.gov/gene/?term=246534 "Dmel_ CG3282, Dmel\CG30291 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00007895 246596 Tango11 http://www.ncbi.nlm.nih.gov/gene/?term=246596 "Dmel_CG30404, BEST:LD33633, BcDNA:LD22567, CG30404, Dmel\CG30404, TANGO11, anon-EST:fe1F11, tango11 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00007896 246627 CG30463 http://www.ncbi.nlm.nih.gov/gene/?term=246627 "Dmel_ CG15713, CG8456, CG8463, Dmel\CG30463, dppGalNAcT9 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00007897 246715 CKS1BP3 http://www.ncbi.nlm.nih.gov/gene/?term=246715 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007898 246721 POLR2J2 http://www.ncbi.nlm.nih.gov/gene/?term=246721 "HRPB11B, RPB11b1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007899 246721 POLR2J2 http://www.ncbi.nlm.nih.gov/gene/?term=246721 "HRPB11B, RPB11b1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007900 246721 POLR2J2 http://www.ncbi.nlm.nih.gov/gene/?term=246721 "HRPB11B, RPB11b1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007901 246728 Oas2 http://www.ncbi.nlm.nih.gov/gene/?term=246728 Oasl11 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007902 24683 Prl http://www.ncbi.nlm.nih.gov/gene/?term=24683 "Gha1, PRLB, PRLSD11a1, Prol, RATPRLSD1, RNPROL, Prl " mRNA Rattus norvegicus 2703695 Nucleus Pituitary In situ hybridization "Figure 4. Electron microscopic autoradiography showing labeling of typical PRL cell. Silver grains are found over the rough endoplasmic reticulum (RER) and nucleus (N). SG, secretory granules; GO, golgi apparatus. Exposure time 14 days. " RLID00007903 24683 Prl http://www.ncbi.nlm.nih.gov/gene/?term=24683 "Gha1, PRLB, PRLSD11a1, Prol, RATPRLSD1, RNPROL, Prl " mRNA Rattus norvegicus 7843989 Ribosome Pituitary cell In situ hybridization "Preembedding electron microscopic ISH localized rat growth hormone and prolactin mRNAs on the polysomes of the rough endoplasmic reticulum (RER). Rat growth hormone mRNA was distributed diffusely on the RER, whereas rat prolactin mRNA was scattered and distributed focally. Thus there might be a specific translational site for prolactin mRNA on the RER. Rat growth hormone mRNA signals were also recognized on the polysomes of the RER, using the postembedding method with streptavidin gold conjugate. " RLID00007904 24683 Prl http://www.ncbi.nlm.nih.gov/gene/?term=24683 "Gha1, PRLB, PRLSD11a1, Prol, RATPRLSD1, RNPROL, Prl " mRNA Rattus norvegicus 7843989 Endoplasmic reticulum Pituitary cell In situ hybridization "Preembedding electron microscopic ISH localized rat growth hormone and prolactin mRNAs on the polysomes of the rough endoplasmic reticulum (RER). Rat growth hormone mRNA was distributed diffusely on the RER, whereas rat prolactin mRNA was scattered and distributed focally. Thus there might be a specific translational site for prolactin mRNA on the RER. Rat growth hormone mRNA signals were also recognized on the polysomes of the RER, using the postembedding method with streptavidin gold conjugate. " RLID00007905 24683 Prl http://www.ncbi.nlm.nih.gov/gene/?term=24683 "Gha1, PRLB, PRLSD11a1, Prol, RATPRLSD1, RNPROL, Prl " mRNA Rattus norvegicus 9361267 Endoplasmic reticulum Pituitary glands In situ hybridization "With ISH, the expression and distribution of PRL messenger ribonucleic acid (mRNA) was observed in a fashion suggesting polysome-like structures on RER. These observations were confirmed by immunoelectron microscopy and electron microscopic ISH. " RLID00007906 24683 Prl http://www.ncbi.nlm.nih.gov/gene/?term=24683 "Gha1, PRLB, PRLSD11a1, Prol, RATPRLSD1, RNPROL, Prl " mRNA Rattus norvegicus 2703695 Endoplasmic reticulum Pituitary In situ hybridization Figure 5. Ultra-thin section which was immunolabeled for PAL localization before the autoradiographic procedure. The small secretory granules are decorated with gold particles (arrows) and silver grains are seen over the rough endoplasmic reticulum (AER). An adjacent GH cell is unlabeled. Exposure time 14 days. RLID00007907 24684 Prlr http://www.ncbi.nlm.nih.gov/gene/?term=24684 RATPRLR mRNA Rattus norvegicus 7606212 Endoplasmic reticulum Hepatocyte In situ hybridization "The expression of both the long and short forms of PRL-receptor mRNA was readily identified in the cytoplasmic matrix, and in association with the endoplasmic reticulum, but a low expression of these forms was detected in the nucleus of hepatocyte. " RLID00007908 24684 Prlr http://www.ncbi.nlm.nih.gov/gene/?term=24684 RATPRLR mRNA Rattus norvegicus 7606212 Nucleus Hepatocyte In situ hybridization "The expression of both the long and short forms of PRL-receptor mRNA was readily identified in the cytoplasmic matrix, and in association with the endoplasmic reticulum, but a low expression of these forms was detected in the nucleus of hepatocyte. " RLID00007909 24684 Prlr http://www.ncbi.nlm.nih.gov/gene/?term=24684 RATPRLR mRNA Rattus norvegicus 7606212 Cytoplasm Hepatocyte In situ hybridization "The expression of both the long and short forms of PRL-receptor mRNA was readily identified in the cytoplasmic matrix, and in association with the endoplasmic reticulum, but a low expression of these forms was detected in the nucleus of hepatocyte. " RLID00007910 24685 Prm1 http://www.ncbi.nlm.nih.gov/gene/?term=24685 mRNA Rattus norvegicus 1795020 Nucleus Spermatids In situ hybridization During early spermiogenesis (before step 7) nuclear transcripts of both TP 1 and Prm 1 were seen. After step 7 the TP 1 and Prm 1 mRNAs were only detected in the cytoplasm. During early spermiogenesis (before step 7) nuclear transcripts of both TP 1 and Prm 1 were seen. After step 7 the TP 1 and Prm 1 mRNAs were only detected in the cytoplasm. RLID00007911 24685 Prm1 http://www.ncbi.nlm.nih.gov/gene/?term=24685 mRNA Rattus norvegicus 1795020 Cytoplasm Spermatids In situ hybridization During early spermiogenesis (before step 7) nuclear transcripts of both TP 1 and Prm 1 were seen. After step 7 the TP 1 and Prm 1 mRNAs were only detected in the cytoplasm. During early spermiogenesis (before step 7) nuclear transcripts of both TP 1 and Prm 1 were seen. After step 7 the TP 1 and Prm 1 mRNAs were only detected in the cytoplasm. RLID00007912 24688 Prph http://www.ncbi.nlm.nih.gov/gene/?term=24688 "Perf1, Prph " mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00007913 24688 Prph http://www.ncbi.nlm.nih.gov/gene/?term=24688 "Perf1, Prph " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00007914 246 ALOX15 http://www.ncbi.nlm.nih.gov/gene/?term=246 "12-LOX, 15-LOX-1, 15LOX-1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007915 246 ALOX15 http://www.ncbi.nlm.nih.gov/gene/?term=246 "12-LOX, 15-LOX-1, 15LOX-1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007916 24720 Rn5s http://www.ncbi.nlm.nih.gov/gene/?term=24720 Rn5s2 rRNA Rattus norvegicus 26180210 Axon Spinal cord In situ hybridization "These axons also contain 5S rRNA, phosphorylated S6 ribosomal protein, eIF2α translation factor, and 4EBP1 translation factor inhibitory protein. " RLID00007917 2475 MTOR http://www.ncbi.nlm.nih.gov/gene/?term=2475 "FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007918 24773 Sftpa1 http://www.ncbi.nlm.nih.gov/gene/?term=24773 "PSAP, PSP-A, SP-A, Sftp1, Sftpa, Sftpl " mRNA Rattus norvegicus 1540394 Endoplasmic reticulum Lung cell In situ hybridization|Northern blot "The present study demonstrates an overexpression of SP-A mRNA despite the ultrastructural changes in the endoplasmic reticulum of alveolar type II cells in the diabetic lungs, which will provide new information on the regulatory mechanism of SP-A gene expression. " RLID00007919 24786 Sod1 http://www.ncbi.nlm.nih.gov/gene/?term=24786 CuZnSOD mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00007920 24786 Sod1 http://www.ncbi.nlm.nih.gov/gene/?term=24786 CuZnSOD mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00007921 24837 Tnnt2 http://www.ncbi.nlm.nih.gov/gene/?term=24837 "CTTG, Ctt, RATCTTG, Tnnt3 " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00007922 24839 Tnp1 http://www.ncbi.nlm.nih.gov/gene/?term=24839 mRNA Rattus norvegicus 1795020 Nucleus Spermatids In situ hybridization During early spermiogenesis (before step 7) nuclear transcripts of both TP 1 and Prm 1 were seen. After step 7 the TP 1 and Prm 1 mRNAs were only detected in the cytoplasm. During early spermiogenesis (before step 7) nuclear transcripts of both TP 1 and Prm 1 were seen. After step 7 the TP 1 and Prm 1 mRNAs were only detected in the cytoplasm. RLID00007923 24839 Tnp1 http://www.ncbi.nlm.nih.gov/gene/?term=24839 mRNA Rattus norvegicus 1795020 Cytoplasm Spermatids In situ hybridization During early spermiogenesis (before step 7) nuclear transcripts of both TP 1 and Prm 1 were seen. After step 7 the TP 1 and Prm 1 mRNAs were only detected in the cytoplasm. During early spermiogenesis (before step 7) nuclear transcripts of both TP 1 and Prm 1 were seen. After step 7 the TP 1 and Prm 1 mRNAs were only detected in the cytoplasm. RLID00007924 2483 FRG1 http://www.ncbi.nlm.nih.gov/gene/?term=2483 "FRG1A, FSG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007925 24851 Tpm1 http://www.ncbi.nlm.nih.gov/gene/?term=24851 "Alpha-tm, Tma2, Tmsa " mRNA Rattus norvegicus 8581312 Cell body Embryoneuron In situ hybridization TmBr-2 mRNA was distributed throughout the cell body (Figure 1C). RLID00007926 248 ALPI http://www.ncbi.nlm.nih.gov/gene/?term=248 IAP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007927 24917 Kpnb1 http://www.ncbi.nlm.nih.gov/gene/?term=24917 Impnb mRNA Rattus norvegicus 14687545 Axon Sciatic nerve In situ hybridization|RT-PCR We then conducted RT-PCR for importin β in the axons and observed a clear signal indicating the presence of importin β transcripts in the axonal mRNA (Figure 2E). RLID00007928 2491 CENPI http://www.ncbi.nlm.nih.gov/gene/?term=2491 "CENP-I, FSHPRH1, LRPR1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007929 2491 CENPI http://www.ncbi.nlm.nih.gov/gene/?term=2491 "CENP-I, FSHPRH1, LRPR1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007930 2495 FTH1 http://www.ncbi.nlm.nih.gov/gene/?term=2495 "FHC, FTH, FTHL6, HFE5, PIG15, PLIF " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007931 2495 FTH1 http://www.ncbi.nlm.nih.gov/gene/?term=2495 "FHC, FTH, FTHL6, HFE5, PIG15, PLIF " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007932 2495 FTH1 http://www.ncbi.nlm.nih.gov/gene/?term=2495 "FHC, FTH, FTHL6, HFE5, PIG15, PLIF " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007933 249 ALPL http://www.ncbi.nlm.nih.gov/gene/?term=249 "AP-TNAP, APTNAP, HOPS, TNAP, TNSALP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007934 24 ABCA4 http://www.ncbi.nlm.nih.gov/gene/?term=24 "ABC10, ABCR, ARMD2, CORD3, FFM, RMP, RP19, STGD, STGD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007935 25054 Ntrk2 http://www.ncbi.nlm.nih.gov/gene/?term=25054 "RATTRKB1, TRKB1, Tkrb, trk-B, trkB " mRNA Rattus norvegicus 11043561 Dendrite ForeBrain In situ hybridization "In striking contrast with TrkA, the TrkB mRNA showed a clear somatodendritic localization in the majority of the labelled neurons. " RLID00007936 25054 Ntrk2 http://www.ncbi.nlm.nih.gov/gene/?term=25054 "RATTRKB1, TRKB1, Tkrb, trk-B, trkB " mRNA Rattus norvegicus 12121312 Dendrite Hippocampus In situ hybridization "Nonstimulated rats: BDNF, TrkB, and CaMKII-β mRNAs localized in the soma and in the proximal dendrites of hippocampal pyramidal cells, and in the soma only of dentate gyrus (DG) granule cells; CaMKII-α mRNA localized throughout the dendritic length in neurons of all hippocampal subfields. In contrast, CaMKII-? (Figs. 1C and 2D), BDNF (Figs. 1E and 2G), and TrkB mRNAs (Figs.1G and 2J) were localized in the soma and in the proximal dendrites of hippocampal pyramidal cells, and in the soma only of DG granule cells. " RLID00007937 25054 Ntrk2 http://www.ncbi.nlm.nih.gov/gene/?term=25054 "RATTRKB1, TRKB1, Tkrb, trk-B, trkB " mRNA Rattus norvegicus 12121312 Dendrite Hippocampus In situ hybridization "Pilocarpine seizures: increased staining levels of CaMKII-β mRNA throughout the whole dendritic length in all hippocampal subfields; induction of CaMKII-α, BDNF, and TrkB mRNAs dendritic targeting in CA1, CA3, and DG neurons. Data provide evidence that BDNF, TrkB, and CaMKII-α and -β mRNAs are accumulated in the dendrites of specific hippocampal neurons during pilocarpine seizures and kindling development. " RLID00007938 25054 Ntrk2 http://www.ncbi.nlm.nih.gov/gene/?term=25054 "RATTRKB1, TRKB1, Tkrb, trk-B, trkB " mRNA Rattus norvegicus 18497100 Dendrite Hippocampus In situ hybridization "The first clear evidence that BDNF and TrkB mRNAs are located in dendrites was found in primary cultures of rat hippocampal neurons where, under basal conditions, these two mRNAs are localized in the initial dendritic compartment (an average of 31.5m from the cell soma considering all types of dendrites and within a range of 30-100m from the cell soma, when considering apical dendrites only). " RLID00007939 25085 Th http://www.ncbi.nlm.nih.gov/gene/?term=25085 The mRNA Rattus norvegicus 9691425 Cytoplasm Brain In situ hybridization "Using exon-specific probes and electron microscopic in situ hybridization in reserpine-treated animals, we have demonstrated that the TH mRNA is localized both in the perikaryal cytoplasm (in association with domains of the endoplasmic reticulum) and in the nucleus (in large and smaller aggregates). " RLID00007940 25085 Th http://www.ncbi.nlm.nih.gov/gene/?term=25085 The mRNA Rattus norvegicus 9691425 Nucleus Brain In situ hybridization "Using exon-specific probes and electron microscopic in situ hybridization in reserpine-treated animals, we have demonstrated that the TH mRNA is localized both in the perikaryal cytoplasm (in association with domains of the endoplasmic reticulum) and in the nucleus (in large and smaller aggregates). " RLID00007941 250 ALPP http://www.ncbi.nlm.nih.gov/gene/?term=250 "ALP, PALP, PLAP, PLAP-1 " mRNA Homo sapiens 24019514 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmid containing either full-length ALPP, t-ftz, AP1, AP2, AP3, AP4, or AP5 and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (C or Ctrl) or HHT (H) for 30 min and then extracted with digitonin. Cells were then fixed, stained for mRNAs using specific FISH probes (ftz probe was used to detect AP1-5), and imaged. Figure 3A, quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 3. " RLID00007942 250 ALPP http://www.ncbi.nlm.nih.gov/gene/?term=250 "ALP, PALP, PLAP, PLAP-1 " mRNA Homo sapiens 24019514 Nucleus COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmid containing either full-length ALPP, t-ftz, AP1, AP2, AP3, AP4, or AP5 and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (C or Ctrl) or HHT (H) for 30 min and then extracted with digitonin. Cells were then fixed, stained for mRNAs using specific FISH probes (ftz probe was used to detect AP1-5), and imaged. Figure 3A, quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 3. " RLID00007943 250 ALPP http://www.ncbi.nlm.nih.gov/gene/?term=250 "ALP, PALP, PLAP, PLAP-1 " mRNA Homo sapiens 26272916 Endoplasmic reticulum U2OS cell Fluorescence in situ hybridization "As mentioned above, we have previously demonstrated that >50% of ALPP mRNA is associated with the ER in a translation-dependent manner and that the remaining fraction is largely dependent on p180 (Cui et al., 2012). " RLID00007944 250 ALPP http://www.ncbi.nlm.nih.gov/gene/?term=250 "ALP, PALP, PLAP, PLAP-1 " mRNA Homo sapiens 22679391 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "Figure 2: ALPP and CALR, but not t-ftz or INSL3, mRNA remain associated with the ER independently of ribosomes and translation. (A–E) COS-7 cells were transfected with plasmids containing either the t-ftz (A), INSL3 (A–B), ALPP (A, C), cyto-ALPP (a version of ALPP lacking signal sequence and transmembrane domain coding regions; A, D–E), or CALR (A) genes and allowed to express mRNA for 18�4 h. The cells were then treated with DMSO (Cont), puromycin, or HHT for 30 min, and then extracted with digitonin alone or with 20 mM EDTA. Cells were then fixed, stained for mRNA using specific FISH probes, and imaged (see panels B–D for examples). The fluorescence intensities of mRNA in the ER and nucleus in the micrographs were quantified (A). Each bar represents the average and standard error of three independent experiments, each consisting of the average integrated intensity of 30 cells over background. Note that although ribosome disruption caused INSL3 mRNA to dissociate from the ER, the nuclear mRNA was unaffected (B, nuclei are denoted by arrows). (E) A single field of view containing a single HHT-treated, digitonin-extracted, COS-7 cell expressing cyto-ALPP mRNA. cyto-ALPP mRNA was visualized by FISH and for Trapα protein by immunofluorescence. Note the extensive co-localization of cyto-ALPP mRNA (red) and Trapα (green) in the overlay. All scale bars?=?20 um. Data are collected from Figure 2. " RLID00007945 250 ALPP http://www.ncbi.nlm.nih.gov/gene/?term=250 "ALP, PALP, PLAP, PLAP-1 " mRNA Homo sapiens 22679391 Nucleus COS-7 cell Fluorescence in situ hybridization "Figure 2: ALPP and CALR, but not t-ftz or INSL3, mRNA remain associated with the ER independently of ribosomes and translation. (A–E) COS-7 cells were transfected with plasmids containing either the t-ftz (A), INSL3 (A–B), ALPP (A, C), cyto-ALPP (a version of ALPP lacking signal sequence and transmembrane domain coding regions; A, D–E), or CALR (A) genes and allowed to express mRNA for 18�4 h. The cells were then treated with DMSO (Cont), puromycin, or HHT for 30 min, and then extracted with digitonin alone or with 20 mM EDTA. Cells were then fixed, stained for mRNA using specific FISH probes, and imaged (see panels B–D for examples). The fluorescence intensities of mRNA in the ER and nucleus in the micrographs were quantified (A). Each bar represents the average and standard error of three independent experiments, each consisting of the average integrated intensity of 30 cells over background. Note that although ribosome disruption caused INSL3 mRNA to dissociate from the ER, the nuclear mRNA was unaffected (B, nuclei are denoted by arrows). (E) A single field of view containing a single HHT-treated, digitonin-extracted, COS-7 cell expressing cyto-ALPP mRNA. cyto-ALPP mRNA was visualized by FISH and for Trapα protein by immunofluorescence. Note the extensive co-localization of cyto-ALPP mRNA (red) and Trapα (green) in the overlay. All scale bars?=?20 um. Data are collected from Figure 2. " RLID00007946 25113 Ddn http://www.ncbi.nlm.nih.gov/gene/?term=25113 Den mRNA Rattus norvegicus 9073398 Dendrite Hippocamus In situ hybridization "In the hippocamus, DEN mRNA is highly expressed in the cell laminae and dendritic layers of the dentate gyrus and CA1 field, but expression is markedly reduced in the CA3 and CA4 areas. The most compelling observation regarding DEN mRNA localization in the adult rat brain is the clear dendritic distribution of the transcripts in the hippocampus (Figs. 1A and 1C). " RLID00007947 25116 Hsd11b1 http://www.ncbi.nlm.nih.gov/gene/?term=25116 LRRGT00065 mRNA Oryctolagus cuniculus 9699885 Endoplasmic reticulum Kidney RT-PCR|Northern analysis "Co-staining with markers for ER proteins, the Golgi membrane, mitochondria and nucleus confirmed that 11beta-HSD2 is localized exclusively to the ER. " RLID00007948 2512 FTL http://www.ncbi.nlm.nih.gov/gene/?term=2512 "LFTD, NBIA3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007949 2512 FTL http://www.ncbi.nlm.nih.gov/gene/?term=2512 "LFTD, NBIA3 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007950 2512 FTL http://www.ncbi.nlm.nih.gov/gene/?term=2512 "LFTD, NBIA3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007951 2512 FTL http://www.ncbi.nlm.nih.gov/gene/?term=2512 "LFTD, NBIA3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007952 251414 zpg http://www.ncbi.nlm.nih.gov/gene/?term=251414 "Dmel_CG10125, CG10125, Dm-inx4, Dmel\CG10125, FBpp0076692, Inx4, Zpg, inx-4, inx4 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00007953 251645 CG32276 http://www.ncbi.nlm.nih.gov/gene/?term=251645 "Dmel_ BcDNA:RE27904, Dmel\CG32276 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00007954 2516 NR5A1 http://www.ncbi.nlm.nih.gov/gene/?term=2516 "AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3 " mRNA Homo sapiens 24019514 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmids containing either ALPP, t-ftz, or the AF1, AF2 fusion constructs and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (Ctrl), puromycin (Puro), or HHT for 30 min and then extracted with either digitonin alone, or for puromycin-treated cells, with 20 mM EDTA. The cells were then fixed, stained for mRNA using specific FISH probes (ALPP probe for AF1, ftz probe for AF2), and imaged. FIGURE 2B: quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 2. " RLID00007955 2516 NR5A1 http://www.ncbi.nlm.nih.gov/gene/?term=2516 "AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3 " mRNA Homo sapiens 24019514 Nucleus COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmids containing either ALPP, t-ftz, or the AF1, AF2 fusion constructs and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (Ctrl), puromycin (Puro), or HHT for 30 min and then extracted with either digitonin alone, or for puromycin-treated cells, with 20 mM EDTA. The cells were then fixed, stained for mRNA using specific FISH probes (ALPP probe for AF1, ftz probe for AF2), and imaged. FIGURE 2B: quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 2. " RLID00007956 2516 NR5A1 http://www.ncbi.nlm.nih.gov/gene/?term=2516 "AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3 " mRNA Homo sapiens 22679391 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "In order to ensure that this technique effectively separates these two classes of mRNA while simultaneously preserving the ultrastructure of the ER, the distribution of various versions of the fushi tarazu (ftz) mRNA fragment were examined in COS-7 cells by fluorescent in situ hybridization (FISH). First we monitored t-ftz mRNA, which encodes a secreted version of the ftz protein [30]. This mRNA, which localizes to the ER ([30] and Figure S1A), remained associated with the cells after digitonin extraction (Figure S1B-C). " RLID00007957 2516 NR5A1 http://www.ncbi.nlm.nih.gov/gene/?term=2516 "AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3 " mRNA Homo sapiens 22679391 Nucleus COS-7 cell Fluorescence in situ hybridization "Figure 2: ALPP and CALR, but not t-ftz or INSL3, mRNA remain associated with the ER independently of ribosomes and translation. (A–E) COS-7 cells were transfected with plasmids containing either the t-ftz (A), INSL3 (A–B), ALPP (A, C), cyto-ALPP (a version of ALPP lacking signal sequence and transmembrane domain coding regions; A, D–E), or CALR (A) genes and allowed to express mRNA for 18�4 h. The cells were then treated with DMSO (Cont), puromycin, or HHT for 30 min, and then extracted with digitonin alone or with 20 mM EDTA. Cells were then fixed, stained for mRNA using specific FISH probes, and imaged (see panels B–D for examples). The fluorescence intensities of mRNA in the ER and nucleus in the micrographs were quantified (A). Each bar represents the average and standard error of three independent experiments, each consisting of the average integrated intensity of 30 cells over background. Note that although ribosome disruption caused INSL3 mRNA to dissociate from the ER, the nuclear mRNA was unaffected (B, nuclei are denoted by arrows). (E) A single field of view containing a single HHT-treated, digitonin-extracted, COS-7 cell expressing cyto-ALPP mRNA. cyto-ALPP mRNA was visualized by FISH and for Trapα protein by immunofluorescence. Note the extensive co-localization of cyto-ALPP mRNA (red) and Trapα (green) in the overlay. All scale bars?=?20 um. Data are collected from Figure 2. " RLID00007958 2517 FUCA1 http://www.ncbi.nlm.nih.gov/gene/?term=2517 FUCA mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007959 2517 FUCA1 http://www.ncbi.nlm.nih.gov/gene/?term=2517 FUCA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007960 2517 FUCA1 http://www.ncbi.nlm.nih.gov/gene/?term=2517 FUCA mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007961 2519 FUCA2 http://www.ncbi.nlm.nih.gov/gene/?term=2519 dJ20N2.5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007962 2519 FUCA2 http://www.ncbi.nlm.nih.gov/gene/?term=2519 dJ20N2.5 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00007963 25203 Ccnb1 http://www.ncbi.nlm.nih.gov/gene/?term=25203 mRNA Rattus norvegicus 8809408 Ribosome Liver RNase protection analysis "In addition, cytoplasmic protein levels of cyclin B1 exhibited a constant distribution in subfractions of microsome- and polysome-associated and free proteins. Cyclin B1 RNA also localized to these three cytoplasmic subfractions. " RLID00007964 2521 FUS http://www.ncbi.nlm.nih.gov/gene/?term=2521 "ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007965 2521 FUS http://www.ncbi.nlm.nih.gov/gene/?term=2521 "ALS6, ETM41, HNRNPP2, POMP75, TLS, FUS " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007966 2521 FUS http://www.ncbi.nlm.nih.gov/gene/?term=2521 "ALS6, ETM41, HNRNPP2, POMP75, TLS, FUS " mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00007967 2523 FUT1 http://www.ncbi.nlm.nih.gov/gene/?term=2523 "H, HH, HSC " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007968 2523 FUT1 http://www.ncbi.nlm.nih.gov/gene/?term=2523 "H, HH, HSC " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007969 2524 FUT2 http://www.ncbi.nlm.nih.gov/gene/?term=2524 "B12QTL1, SE, SEC2, Se2, sej " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007970 2524 FUT2 http://www.ncbi.nlm.nih.gov/gene/?term=2524 "B12QTL1, SE, SEC2, Se2, sej " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007971 2525 FUT3 http://www.ncbi.nlm.nih.gov/gene/?term=2525 "CD174, FT3B, FucT-III, LE, Les " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007972 25262 Itpr1 http://www.ncbi.nlm.nih.gov/gene/?term=25262 "I145TR, IP3R1, InsP3R, InsP3R1, P400 " mRNA Mus musculus 8081710 Dendrite Purkinje cell In situ hybridization "In the most abundantly expressing Purkinje cells, InsP3R1 mRNA appeared to be translocated to the distal dendrites, since a strong hybridization density was observed in the molecular layer of the cerebellum. " RLID00007973 25267 Pdgfra http://www.ncbi.nlm.nih.gov/gene/?term=25267 "APDGFR, PDGFACE " mRNA Rattus norvegicus 9073394 Cell body Medullary velum In situ hybridization "The high level of expression of PDGF-alphaR mRNA in the AMV of juvenile rats, localized to cell bodies within the myelinated axon tracts, strongly suggesting that oligodendrocyte precursors persisted in the mature velum " RLID00007974 2526 FUT4 http://www.ncbi.nlm.nih.gov/gene/?term=2526 "CD15, ELFT, FCT3A, FUC-TIV, FUTIV, LeX, SSEA-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007975 252829 Obox5 http://www.ncbi.nlm.nih.gov/gene/?term=252829 C87544 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007976 252839 TMEM9 http://www.ncbi.nlm.nih.gov/gene/?term=252839 TMEM9A mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007977 252839 TMEM9 http://www.ncbi.nlm.nih.gov/gene/?term=252839 "DERM4A, TMEM9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007978 252866 Adam34 http://www.ncbi.nlm.nih.gov/gene/?term=252866 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00007979 252870 Usp7 http://www.ncbi.nlm.nih.gov/gene/?term=252870 "2210010O09Rik, AA409944, AA617399, AU019296, AW548146, C80752, Hausp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007980 252875 Mios http://www.ncbi.nlm.nih.gov/gene/?term=252875 C81488 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007981 2528 FUT6 http://www.ncbi.nlm.nih.gov/gene/?term=2528 "FCT3A, FT1A, Fuc-TVI, FucT-VI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007982 252948 TTTY16 http://www.ncbi.nlm.nih.gov/gene/?term=252948 NCRNA00139 lncRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00007983 252952 TTTY19 http://www.ncbi.nlm.nih.gov/gene/?term=252952 NCRNA00144 lncRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00007984 252969 NEIL2 http://www.ncbi.nlm.nih.gov/gene/?term=252969 "NEH2, NEI2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007985 252969 NEIL2 http://www.ncbi.nlm.nih.gov/gene/?term=252969 "NEH2, NEI2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007986 252969 NEIL2 http://www.ncbi.nlm.nih.gov/gene/?term=252969 "NEH2, NEI2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00007987 252974 Tspear http://www.ncbi.nlm.nih.gov/gene/?term=252974 "C330046G03Rik, ORF65, TSP-EAR, Tnep1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00007988 252995 FNDC5 http://www.ncbi.nlm.nih.gov/gene/?term=252995 "FRCP2, irisin " mRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00007989 253012 HEPACAM2 http://www.ncbi.nlm.nih.gov/gene/?term=253012 MIKI mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007990 25307 Cst3 http://www.ncbi.nlm.nih.gov/gene/?term=25307 CYSC mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00007991 2530 FUT8 http://www.ncbi.nlm.nih.gov/gene/?term=2530 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007992 253143 PRR14L http://www.ncbi.nlm.nih.gov/gene/?term=253143 C22orf30 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007993 253143 PRR14L http://www.ncbi.nlm.nih.gov/gene/?term=253143 C22orf30 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00007994 2531 KDSR http://www.ncbi.nlm.nih.gov/gene/?term=2531 "DHSR, FVT1, SDR35C1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007995 25320 Gast http://www.ncbi.nlm.nih.gov/gene/25320 "Gas, PPG34 " mRNA Rattus norvegicus 8812056 Endoplasmic reticulum Hypothalamus In situ hybridization "Altogether, these ultrastructural studies strongly suggested that the Gas and AVP mRNAs might be associated with distinct domains of the RER. " RLID00007996 25327 Kcnc1 http://www.ncbi.nlm.nih.gov/gene/?term=25327 "KShIIIB, Kv3.1, Kv4, NGK2-KV4 " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00007997 2532 ACKR1 http://www.ncbi.nlm.nih.gov/gene/?term=2532 "CCBP1, CD234, DARC, Dfy, FY, GPD, GpFy, WBCQ1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007998 2533 FYB http://www.ncbi.nlm.nih.gov/gene/?term=2533 "ADAP, PRO0823, SLAP-130, SLAP130 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00007999 253430 IPMK http://www.ncbi.nlm.nih.gov/gene/?term=253430 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008000 2534 FYN http://www.ncbi.nlm.nih.gov/gene/?term=2534 "SLK, SYN, p59-FYN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008001 253558 LCLAT1 http://www.ncbi.nlm.nih.gov/gene/?term=253558 "1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LYCAT, UNQ1849 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008002 253558 LCLAT1 http://www.ncbi.nlm.nih.gov/gene/?term=253558 "1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LYCAT, UNQ1849 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008003 253650 ANKRD18A http://www.ncbi.nlm.nih.gov/gene/?term=253650 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008004 253714 MMS22L http://www.ncbi.nlm.nih.gov/gene/?term=253714 "C6orf167, dJ39B17.2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008005 253714 MMS22L http://www.ncbi.nlm.nih.gov/gene/?term=253714 "C6orf167, dJ39B17.2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008006 253714 MMS22L http://www.ncbi.nlm.nih.gov/gene/?term=253714 "C6orf167, dJ39B17.2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008007 253738 EBF3 http://www.ncbi.nlm.nih.gov/gene/?term=253738 "COE3, EBF-3, O/E-2, OE-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008008 253769 WDR27 http://www.ncbi.nlm.nih.gov/gene/?term=253769 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008009 253769 WDR27 http://www.ncbi.nlm.nih.gov/gene/?term=253769 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008010 253782 CERS6 http://www.ncbi.nlm.nih.gov/gene/?term=253782 "CERS5, LASS6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008011 253782 CERS6 http://www.ncbi.nlm.nih.gov/gene/?term=253782 "CERS5, LASS6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008012 253782 CERS6 http://www.ncbi.nlm.nih.gov/gene/?term=253782 "CERS5, LASS6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008013 2537 IFI6 http://www.ncbi.nlm.nih.gov/gene/?term=2537 "6-16, FAM14C, G1P3, IFI-6-16, IFI616 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008014 2537 IFI6 http://www.ncbi.nlm.nih.gov/gene/?term=2537 "6-16, FAM14C, G1P3, IFI-6-1616, IFI6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008015 253832 ZDHHC20 http://www.ncbi.nlm.nih.gov/gene/?term=253832 "4933421L13Rik, DHHC-20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008016 2538 G6PC http://www.ncbi.nlm.nih.gov/gene/?term=2538 "G6PC1, G6PT, GSD1, GSD1a " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008017 2538 G6PC http://www.ncbi.nlm.nih.gov/gene/?term=2538 "G6PC1, G6PT, GSD1, GSD1a " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008018 2539667 ash2 http://www.ncbi.nlm.nih.gov/gene/?term=2539667 SPBC13G1.08c mRNA Saccharomyces cerevisiae 18805955 Cellular bud Yeast qRT-PCR "Khd1p associates with a subset of bud-tip-localized mRNAs. ASH1, MID2, and MTL1 mRNAs, but not BRO1 mRNA, were detected by RT-PCR in RNAs isolated from total extracts (Input) and from Khd1p-TAP affinity isolations (Khd1p).overexpression inhibits ASH1 expression (Irie et al. 2002). Therefore, we systematically examined whether Khd1p modifies protein expression of other bud-tip-localized mRNAs that are bound by Khd1p (MID2, MTL1, WSC2, SRL1, EGT2, and CLB2). " RLID00008019 253980 KCTD13 http://www.ncbi.nlm.nih.gov/gene/?term=253980 "BACURD1, FKSG86, PDIP1, POLDIP1, hBACURD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008020 25398 Cacna1a http://www.ncbi.nlm.nih.gov/gene/?term=25398 "BccA1, Cav2.1, rbA-1 " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00008021 2539 G6PD http://www.ncbi.nlm.nih.gov/gene/?term=2539 G6PD1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008022 25400 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=25400 "PK2CDD, PKCCD " mRNA Rattus norvegicus 1311815 Dendrite Hippocampus In situ hybridization "These data suggest that CaM II kinase a mRNA is expressed in the dendrites of hippocampal pyramidal cells and, therefore, is likely to be expressed in dendrites in other regions of the central nervous system exhibiting CaM II kinase a: cRNA labeling in the neuropil. " RLID00008023 25400 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=25400 "PK2CDD, PKCCD " mRNA Rattus norvegicus 7500833 Dendrite Neuron In situ hybridization In each of these region hybridization was decreased in the molecular layers which is consistent with the reported dendritic localization of alpha CamKII mRNA. RLID00008024 25400 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=25400 "PK2CDD, PKCCD " mRNA Rattus norvegicus 7773006 Dendrite Neuron In situ hybridization "Table 1. As of 1994, mRNAs that have been localized within dendrites by in situ hybridization. Data are collected from Table 1. " RLID00008025 25400 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=25400 "PK2CDD, PKCCD " mRNA Rattus norvegicus 9322162 Cell body Hippocampus In situ hybridization "In most neurons that express a CaMII kinase, the highest levels of the mRNA were in the cell body, but labeling was also present throughout dendrites. " RLID00008026 25400 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=25400 "PK2CDD, PKCCD " mRNA Rattus norvegicus 12121312 Dendrite Hippocampus In situ hybridization "Nonstimulated rats: BDNF, TrkB, and CaMKII-β mRNAs localized in the soma and in the proximal dendrites of hippocampal pyramidal cells, and in the soma only of dentate gyrus (DG) granule cells; CaMKII-α mRNA localized throughout the dendritic length in neurons of all hippocampal subfields. In contrast, CaMKII-? (Figs. 1C and 2D), BDNF (Figs. 1E and 2G), and TrkB mRNAs (Figs.1G and 2J) were localized in the soma and in the proximal dendrites of hippocampal pyramidal cells, and in the soma only of DG granule cells. " RLID00008027 25400 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=25400 "PK2CDD, PKCCD " mRNA Rattus norvegicus 12121312 Dendrite Hippocampus In situ hybridization "Pilocarpine seizures: increased staining levels of CaMKII-β mRNA throughout the whole dendritic length in all hippocampal subfields; induction of CaMKII-α, BDNF, and TrkB mRNAs dendritic targeting in CA1, CA3, and DG neurons. Data provide evidence that BDNF, TrkB, and CaMKII-α and -β mRNAs are accumulated in the dendrites of specific hippocampal neurons during pilocarpine seizures and kindling development. " RLID00008028 25400 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=25400 "PK2CDD, PKCCD " mRNA Rattus norvegicus 20237286 Dendrite Hippocampus Fluorescence in situ hybridization "When MAP2 3'-UTR/GAPDH and CaMKIIa 3'-UTR/GAPDH pairs (Fig. 2A,B) were coinjected in mature neurons, MAP2 and CaMKIIa 3'-UTRs were transported as particles into dendrites, whereas GAPDH was retained in the soma. " RLID00008029 25400 Camk2a http://www.ncbi.nlm.nih.gov/gene/?term=25400 "PK2CDD, PKCCD " mRNA Rattus norvegicus 2162385 Dendrite Brain In situ hybridization Our results indicate that CaM-KII alpha- but not beta-subunit mRNA is transported into dendrites. RLID00008030 254048 UBN2 http://www.ncbi.nlm.nih.gov/gene/?term=254048 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008031 254048 UBN2 http://www.ncbi.nlm.nih.gov/gene/?term=254048 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008032 254048 UBN2 http://www.ncbi.nlm.nih.gov/gene/?term=254048 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008033 254065 BRWD3 http://www.ncbi.nlm.nih.gov/gene/?term=254065 "BRODL, MRX93 " mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00008034 254170 FBXO33 http://www.ncbi.nlm.nih.gov/gene/?term=254170 "BMND12, Fbx33, c14_5247 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008035 2541815 bip1 http://www.ncbi.nlm.nih.gov/gene/?term=2541815 "SPAC22A12.15c, bip " mRNA Saccharomyces cerevisiae 23066505 Ribosome Yeast Northern blot "Northern blot analysis of the distribution of total or tBip1 mRNA in polyribosomes from extracts of unstressed or ER-stressed (2 mM DTT, 1 hr) cells. " RLID00008036 25420 Cryab http://www.ncbi.nlm.nih.gov/gene/?term=25420 AACRYA mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00008037 25420 Cryab http://www.ncbi.nlm.nih.gov/gene/?term=25420 AACRYA mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. Data collected from Table 1. RLID00008038 254225 RNF169 http://www.ncbi.nlm.nih.gov/gene/?term=254225 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008039 254295 PHYHD1 http://www.ncbi.nlm.nih.gov/gene/?term=254295 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008040 254295 PHYHD1 http://www.ncbi.nlm.nih.gov/gene/?term=254295 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008041 2542 SLC37A4 http://www.ncbi.nlm.nih.gov/gene/?term=2542 "G6PT1, G6PT2, G6PT3, GSD1b, GSD1c, GSD1d, PRO0685, TRG-19, TRG19 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008042 254359 ZDHHC24 http://www.ncbi.nlm.nih.gov/gene/?term=254359 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008043 25438 Eno3 http://www.ncbi.nlm.nih.gov/gene/?term=25438 "BBE, MSE " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00008044 254394 MCM9 http://www.ncbi.nlm.nih.gov/gene/?term=254394 "C6orf61, MCMDC1, ODG4, dJ329L24.1, dJ329L24.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008045 2543 GAGE1 http://www.ncbi.nlm.nih.gov/gene/?term=2543 "CT4.1, GAGE-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008046 254531 LPCAT4 http://www.ncbi.nlm.nih.gov/gene/?term=254531 "AGPAT7, AYTL3, LPAAT-eta, LPEAT2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008047 254552 NUDT8 http://www.ncbi.nlm.nih.gov/gene/?term=254552 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008048 25459 Hmgb1 http://www.ncbi.nlm.nih.gov/gene/?term=25459 "Ac2-008, Hmg1 " mRNA Rattus norvegicus 25855182 Axon Neuron Fluorescence in situ hybridization|qRT-PCR "Here, we show that amphoterin mRNA localizes into axons via its proximal 3�UTR. " RLID00008049 25459 Hmgb1 http://www.ncbi.nlm.nih.gov/gene/?term=25459 "Ac2-008, Hmg1 " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00008050 25473 Lamb2 http://www.ncbi.nlm.nih.gov/gene/?term=25473 SLAM mRNA Rattus norvegicus 7599960 Synapse Muscle fibers In situ hybridization "N-CAM, 45K-rapsyn, and S-laminin mRNAs are concentrated at synaptic sites in muscle fibers " RLID00008051 2547 XRCC6 http://www.ncbi.nlm.nih.gov/gene/?term=2547 "CTC75, CTCBF, G22P1, KU70, ML8, TLAA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008052 2547 XRCC6 http://www.ncbi.nlm.nih.gov/gene/?term=2547 "CTC75, CTCBF, G22P1, KU70, ML8, TLAA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008053 2547 XRCC6 http://www.ncbi.nlm.nih.gov/gene/?term=2547 "CTC75, CTCBF, G22P1, KU70, ML8, TLAA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008054 254863 TMEM256 http://www.ncbi.nlm.nih.gov/gene/?term=254863 C17orf61 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008055 254887 ZDHHC23 http://www.ncbi.nlm.nih.gov/gene/?term=254887 "DHHC-23, NIDD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008056 2548 GAA http://www.ncbi.nlm.nih.gov/gene/?term=2548 LYAG mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008057 255027 MPV17L http://www.ncbi.nlm.nih.gov/gene/?term=255027 "M-LPH, MLPH1, MLPH21, MPV17L " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008058 255027 MPV17L http://www.ncbi.nlm.nih.gov/gene/?term=255027 "M-LPH, MLPH1, MLPH21, MPV17L " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008059 2550 GABBR1 http://www.ncbi.nlm.nih.gov/gene/?term=2550 "GABABR1, GABBR1-3, GB1, GPRC3A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008060 25518 Ppia http://www.ncbi.nlm.nih.gov/gene/?term=25518 "CYCA, CyP-A " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00008061 2551 GABPA http://www.ncbi.nlm.nih.gov/gene/?term=2551 "E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008062 25522 Prkcz http://www.ncbi.nlm.nih.gov/gene/?term=25522 "14-3-3-zetaisoform, Pkcz, r14-3-3 " mRNA Rattus norvegicus 15371429 Dendrite Hippocampus In situ hybridization "Fig. 1 shows that substantial signal intensities, indicating the presence of PKM-Zeta mRNA, were observed in both somata and dendrites of hippocampal neurons. Again, the labeling signal for PKM-Zeta mRNA was discontinuously distributed along dendritic arborizations. " RLID00008063 255252 LRRC57 http://www.ncbi.nlm.nih.gov/gene/?term=255252 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008064 255252 LRRC57 http://www.ncbi.nlm.nih.gov/gene/?term=255252 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008065 2553 GABPB1 http://www.ncbi.nlm.nih.gov/gene/?term=2553 "BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4TF1B, GABPB, GABPB2, NRF2B1, NRF2B2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008066 2553 GABPB1 http://www.ncbi.nlm.nih.gov/gene/?term=2553 "BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4TF1B, GABPB, GABPB-1, GABPB2, NRF2B1, NRF2B2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008067 255403 ZNF718 http://www.ncbi.nlm.nih.gov/gene/?term=255403 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008068 255488 RNF144B http://www.ncbi.nlm.nih.gov/gene/?term=255488 "IBRDC2, PIR2, bA528A10.3, p53RFP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008069 255488 RNF144B http://www.ncbi.nlm.nih.gov/gene/?term=255488 "IBRDC2, PIR2, bA528A10.3, p53RFP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008070 25550 Slc1a1 http://www.ncbi.nlm.nih.gov/gene/?term=25550 "Eaac1, Eaat3, REAAC1 " mRNA Rattus norvegicus 21185901 Dendrite Hippocampus In situ hybridization "These studies provide the first evidence that EAAC1 mRNA localizes to dendrites and suggest that dendritic targeting of EAAC1 mRNA is increased by seizure activity and may be regulated by neuronal activity/depolarization.restricted to the cell body and proximal dendrites of hippocampal pyramidal neurons in vivo under control conditions. Together, these data provide strong evidence that EAAC1 mRNA is localized in dendrites in vitro. " RLID00008071 255626 HIST1H2BA http://www.ncbi.nlm.nih.gov/gene/?term=255626 "H2BFU, STBP, TH2B, TSH2B, TSH2B.1, bA317E16.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008072 255738 PCSK9 http://www.ncbi.nlm.nih.gov/gene/?term=255738 "FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008073 255812 SDHAP1 http://www.ncbi.nlm.nih.gov/gene/?term=255812 "SDHAL1, SDHALP1 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008074 255877 BCL6B http://www.ncbi.nlm.nih.gov/gene/?term=255877 "BAZF, ZBTB28, ZNF62 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008075 255919 CNEP1R1 http://www.ncbi.nlm.nih.gov/gene/?term=255919 "C16orf69, NEP1-R1, TMEM188, TMP125 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008076 255919 CNEP1R1 http://www.ncbi.nlm.nih.gov/gene/?term=255919 "C16orf69, NEP1-R1, NEP1R1, TMEM188, TMP125 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008077 255919 CNEP1R1 http://www.ncbi.nlm.nih.gov/gene/?term=255919 "C16orf69, NEP1-R1, NEP1R1, TMEM188, TMP125 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008078 255919 CNEP1R1 http://www.ncbi.nlm.nih.gov/gene/?term=255919 "C16orf69, NEP1-R1, NEP1R1, TMEM188, TMP125 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008079 25595 Map2 http://www.ncbi.nlm.nih.gov/gene/?term=25595 "MAP2R, Mtap2 " mRNA Rattus norvegicus 2148487 Cell body Neuron In situ hybridization "In situ hybridization revealed a differential localization of mRNA within dendrites. mRNA encoding MAP2 was abundant in cell bodies and distributed nonhomogeneously throughout the dendritic compartment, but was not detected in axons. " RLID00008080 25595 Map2 http://www.ncbi.nlm.nih.gov/gene/?term=25595 "MAP2R, Mtap2 " mRNA Rattus norvegicus 3200318 Dendrite Neuron In situ hybridization "Here, we use in situ hybridization with specific complementary DNA probes to show that messenger RNA for the dendritic-spcific microtubule associated protein MAP2 is presented in dendrites in developing brain. " RLID00008081 25595 Map2 http://www.ncbi.nlm.nih.gov/gene/?term=25595 "MAP2R, Mtap2 " mRNA Rattus norvegicus 7773006 Dendrite Neuron In situ hybridization "Table 1. As of 1994, mRNAs that have been localized within dendrites by in situ hybridization. Data are collected from Table 1. " RLID00008082 25595 Map2 http://www.ncbi.nlm.nih.gov/gene/?term=25595 "MAP2R, Mtap2 " mRNA Rattus norvegicus 7877439 Dendrite Neuron In situ hybridization "These included MAP2 mRNA, which was identified by deep staining within dendritic fields but by only light staining within neuronal cell bodies. The dendrite-rich molecular layers, in contrast, were deeply and diffusely stained suggesting that most MAP2 mRNA was translocated into the dendrites of hippocampal neurons (Fig. 1B). " RLID00008083 25595 Map2 http://www.ncbi.nlm.nih.gov/gene/?term=25595 "MAP2R, Mtap2 " mRNA Rattus norvegicus 7877439 Cytoplasm Neuron In situ hybridization "Within specific brainstem nuclei, such as the trapezoid nucleus, stain corresponding to MAP2 mRNA was confined to the perinuclear cytoplasm of neurons (Fig. 3A). " RLID00008084 25595 Map2 http://www.ncbi.nlm.nih.gov/gene/?term=25595 "MAP2R, Mtap2 " mRNA Rattus norvegicus 9322162 Dendrite Hippocampus In situ hybridization "In some neurons that express MAP2, the mRNA was present at the highest levels in the proximal third to half of the dendritic arbor, whereas in other neurons the highest levels of labeling were in the cell body. This labeling presumably reflects the presence of MAP2 mRNA in the dendrites of most of the neurons that inhabit the cortex. " RLID00008085 25595 Map2 http://www.ncbi.nlm.nih.gov/gene/?term=25595 "MAP2R, Mtap2 " mRNA Rattus norvegicus 20237286 Dendrite Hippocampus Fluorescence in situ hybridization "When MAP2 3'-UTR/GAPDH and CaMKIIa 3'-UTR/GAPDH pairs (Fig. 2A,B) were coinjected in mature neurons, MAP2 and CaMKIIa 3'-UTRs were transported as particles into dendrites, whereas GAPDH was retained in the soma. " RLID00008086 25595 Map2 http://www.ncbi.nlm.nih.gov/gene/?term=25595 "MAP2R, Mtap2 " mRNA Rattus norvegicus 26512708 Dendrite ForeBrain Immunoprecipitation|RIP-Chip "Rat MARTA-1, a protein that transports MAP-2 mRNA to dendrites " RLID00008087 255967 PAN3 http://www.ncbi.nlm.nih.gov/gene/?term=255967 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008088 2560 GABRB1 http://www.ncbi.nlm.nih.gov/gene/?term=2560 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008089 25617 Hspa5 http://www.ncbi.nlm.nih.gov/gene/?term=25617 "BIP, GRP78 " mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00008090 25617 Hspa5 http://www.ncbi.nlm.nih.gov/gene/?term=25617 "BIP, GRP78 " mRNA Rattus norvegicus 20308067 Axon Neuron Fluorescence in situ hybridization "MRNAs encoding the endoplasmic reticulum chaperone proteins calreticulin and Grp78/BiP were previously detected in sensory axons by RT-PCR and array hybridization (7, 30). Because these analyses used lysed axons that could contain proximal axonal segments, we used FISH to directly visualize the mRNAs in dissociated cultures of DRG neurons. DRG neurons showed punctate FISH signals for beta-actin, calreticulin, and Grp78/BiP mRNAs that extended into growth cones (Fig. 1A). This granular distribution is similar to other mRNAs localizing to dendrites and axons (21).mRNAs encoding the endoplasmic reticulum chaperone proteins calreticulin and Grp78/BiP were previously detected in sensory axons by RT-PCR and array hybridization (7, 30). Because these analyses used lysed axons that could contain proximal axonal segments, we used FISH to directly visualize the mRNAs in dissociated cultures of DRG neurons. DRG neurons showed punctate FISH signals for beta-actin, calreticulin, and Grp78/BiP mRNAs that extended into growth cones (Fig. 1A). This granular distribution is similar to other mRNAs localizing to dendrites and axons (21). " RLID00008091 25617 Hspa5 http://www.ncbi.nlm.nih.gov/gene/?term=25617 "BIP, GRP78 " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00008092 256281 NUDT14 http://www.ncbi.nlm.nih.gov/gene/?term=256281 "UGPP, UGPPase " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008093 256281 NUDT14 http://www.ncbi.nlm.nih.gov/gene/?term=256281 "UGPP, UGPPase " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008094 2562 GABRB3 http://www.ncbi.nlm.nih.gov/gene/?term=2562 ECA5 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008095 2562 GABRB3 http://www.ncbi.nlm.nih.gov/gene/?term=2562 ECA5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008096 256302 NATD1 http://www.ncbi.nlm.nih.gov/gene/?term=256302 "C17orf103, Gtlf3b " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008097 256302 NATD1 http://www.ncbi.nlm.nih.gov/gene/?term=256302 "C17orf103, Gtlf3b " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008098 256302 NATD1 http://www.ncbi.nlm.nih.gov/gene/?term=256302 "C17orf103, Gtlf3b " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008099 256356 GK5 http://www.ncbi.nlm.nih.gov/gene/?term=256356 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008100 256356 GK5 http://www.ncbi.nlm.nih.gov/gene/?term=256356 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008101 256356 GK5 http://www.ncbi.nlm.nih.gov/gene/?term=256356 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008102 256364 EML3 http://www.ncbi.nlm.nih.gov/gene/?term=256364 ELP95 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008103 256364 EML3 http://www.ncbi.nlm.nih.gov/gene/?term=256364 ELP95 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008104 256380 SCML4 http://www.ncbi.nlm.nih.gov/gene/?term=256380 dJ47M23.1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008105 256380 SCML4 http://www.ncbi.nlm.nih.gov/gene/?term=256380 dJ47M23.1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008106 2563 GABRD http://www.ncbi.nlm.nih.gov/gene/?term=2563 "EIG10, EJM7, GEFSP5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008107 256471 MFSD8 http://www.ncbi.nlm.nih.gov/gene/?term=256471 "CCMD, CLN7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008108 2564 GABRE http://www.ncbi.nlm.nih.gov/gene/?term=2564 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008109 256586 LYSMD2 http://www.ncbi.nlm.nih.gov/gene/?term=256586 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008110 256815 C10orf67 http://www.ncbi.nlm.nih.gov/gene/?term=256815 "C10orf115, LINC01552, bA215C7.4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008111 256815 C10orf67 http://www.ncbi.nlm.nih.gov/gene/?term=256815 "C10orf115, LINC01552, bA215C7.4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008112 2568 GABRP http://www.ncbi.nlm.nih.gov/gene/?term=2568 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008113 25695 Cebpd http://www.ncbi.nlm.nih.gov/gene/?term=25695 "C/EBPd, CELF " mRNA Rattus norvegicus 23426691 Dendrite Hippocampus Fluorescence in situ hybridization "C/EBPδ is found in nuclear, somatic, and dendritic compartments, and a dendritic localization of C/EBPδ mRNA in hippocampal neuronal cultures suggests that this transcription factor may be translated at synapses. " RLID00008114 256987 SERINC5 http://www.ncbi.nlm.nih.gov/gene/?term=256987 "C5orf12, TPO1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008115 256987 SERINC5 http://www.ncbi.nlm.nih.gov/gene/?term=256987 "C5orf12, TPO1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008116 25698 Ass1 http://www.ncbi.nlm.nih.gov/gene/?term=25698 "ASSA, Ass " mRNA Rattus norvegicus 8726358 Endoplasmic reticulum Liver In situ hybridization "These ratios showed that the mRNAs for argininosuccinate synthetase and argininosuccinate lyase were located next to the cytoplasmic side of the mitochondrial membrane and in the nearby endoplasmic reticulum. These data show that ASL mRNA is preferentially located at the mitochondrial outer membrane and in the ER. Thus,ASS mRNA, likeASL mRNA, is preferentially located at the mitochondrial outer membrane and in the ER. This suggests that COIII mRNA is actually predominantly associated with those portions of the inner membrane which lie at the mitochondrial perimeter rather than along the cristae. " RLID00008117 25698 Ass1 http://www.ncbi.nlm.nih.gov/gene/?term=25698 "ASSA, Ass " mRNA Rattus norvegicus 8726358 Mitochondrion Liver In situ hybridization "A method was developed to study the intracellular distribution of ASS and ASL mRNAs in rat liver at the ultrastructural level, using in situ RT-PCR (reverse transcription and the polymerase chain reaction). The results indicate that these mRNAs are localized to areas of the cytoplasm adjacent to, or in the immediate vicinity of, the mitochondria.For experiments using the ASS primers, ratios similar to those for ASL were obtained, again regardless of the specific experimental procedures followed. For all silver grains, the ratios for mitochondrial outer membrane were 2.36 & 0.40 and 2.18 -+ 0.33, and those for ER were 1.36 * 0.20 and 1.19 2 0.18 after in situ RT-PCR or in situ RT, respectively, while the ratios for mitochondrial matrix and other structures were < 1.0 (Table I, ASS data). Consideration of only medium/large grains gave similar ratios (not shown). Thus, ASS mRNA, like ASL mRNA, is preferentially located at the mitochondrial outer membrane and in the ER. " RLID00008118 257000 TINCR http://www.ncbi.nlm.nih.gov/gene/?term=257000 "LINC00036, NCRNA00036, PLAC2, onco-lncRNA-16 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008119 257000 TINCR http://www.ncbi.nlm.nih.gov/gene/?term=257000 "LINC00036, NCRNA00036, PLAC2, onco-lncRNA-16 " lncRNA Homo sapiens 23201690 Cytoplasm Keratinocytes In situ hybridization "Single-molecule RNA fluorescence in situ hybridization (FISH) identified 80.6% of TINCR molecules newly acquired during differentiation within the cytoplasm (Supplementary Fig. 1e, f). " RLID00008120 257106 ARHGAP30 http://www.ncbi.nlm.nih.gov/gene/?term=257106 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008121 25718 Igf1r http://www.ncbi.nlm.nih.gov/gene/?term=25718 "IGF-1 receptor, IGFIRC, Igfr1, JTK13 " mRNA Rattus norvegicus 1658638 Cell body Brain In situ hybridization "IGF-I-R mRNA is synthesized in neuronal cell bodies, and the receptors are transported to axons and dendrites in adjacent synapse-rich layers. " RLID00008122 2571 GAD1 http://www.ncbi.nlm.nih.gov/gene/?term=2571 "CPSQ1, GAD, SCP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008123 25728 Apoe http://www.ncbi.nlm.nih.gov/gene/?term=25728 APOEA mRNA Rattus norvegicus 20456011 Cell body Hippocampus In situ hybridization The in situ signals of APOE mRNA (Fig. 1a and b) and other candidates (see Figure S2) were detected in both the cell bodies and dendrites of the cultured hippocampal neurons. RLID00008124 25728 Apoe http://www.ncbi.nlm.nih.gov/gene/?term=25728 APOEA mRNA Rattus norvegicus 20456011 Dendrite Hippocampus In situ hybridization The in situ signals of APOE mRNA (Fig. 1a and b) and other candidates (see Figure S2) were detected in both the cell bodies and dendrites of the cultured hippocampal neurons. RLID00008125 257397 TAB3 http://www.ncbi.nlm.nih.gov/gene/?term=257397 "MAP3K7IP3, NAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008126 25739 Pygb http://www.ncbi.nlm.nih.gov/gene/?term=25739 GLYPHOA mRNA Rattus norvegicus 24898526 Axon Spinal motoneuron In situ hybridization|qRT-PCR "To study the mRNA expression of GP and GS, the key enzymes of glycogen metabolism, we applied FISH on cultured spinal motoneurons. This also allowed us to investigate the distribution of these mRNAs in soma, dendrites and axons. GP mRNA was present in the cell soma as well as in processes (Figure 1a, d, arrows). The signal overlapped with the signal for MAP2 (Figure 1b,c) as well as that for tau (Figure 1e, f) indicating the presence of the mRNA in dendrites as well as in axons. " RLID00008127 25739 Pygb http://www.ncbi.nlm.nih.gov/gene/?term=25739 GLYPHOA mRNA Rattus norvegicus 24898526 Dendrite Spinal motoneuron In situ hybridization|qRT-PCR "To study the mRNA expression of GP and GS, the key enzymes of glycogen metabolism, we applied FISH on cultured spinal motoneurons. This also allowed us to investigate the distribution of these mRNAs in soma, dendrites and axons. GP mRNA was present in the cell soma as well as in processes (Figure? 1a, d, arrows). The signal overlapped with the signal for MAP2 (Figure? 1b,c) as well as that for tau (Figure? 1e, f) indicating the presence of the mRNA in dendrites as well as in axons. " RLID00008128 257407 C2orf72 http://www.ncbi.nlm.nih.gov/gene/?term=257407 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008129 257415 FAM133B http://www.ncbi.nlm.nih.gov/gene/?term=257415 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008130 25764 HYPK http://www.ncbi.nlm.nih.gov/gene/?term=25764 "C15orf63, HSPC136 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008131 25766 PRPF40B http://www.ncbi.nlm.nih.gov/gene/?term=25766 HYPC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008132 25771 TBC1D22A http://www.ncbi.nlm.nih.gov/gene/?term=25771 "C22orf4, HSC79E021 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008133 25771 TBC1D22A http://www.ncbi.nlm.nih.gov/gene/?term=25771 "C22orf4, HSC79E021 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008134 25776 CBY1 http://www.ncbi.nlm.nih.gov/gene/?term=25776 "C22orf2, CBY, HS508I15A, PGEA1, PIGEA-14, PIGEA14, arb1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008135 25777 SUN2 http://www.ncbi.nlm.nih.gov/gene/?term=25777 UNC84B mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008136 25778 DSTYK http://www.ncbi.nlm.nih.gov/gene/?term=25778 "CAKUT1, DustyPK, HDCMD38P, RIP5, RIPK5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008137 25782 RAB3GAP2 http://www.ncbi.nlm.nih.gov/gene/?term=25782 "RAB3-GAP150, RAB3GAP150, SPG69, WARBM2, p150 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008138 25782 RAB3GAP2 http://www.ncbi.nlm.nih.gov/gene/?term=25782 "RAB3-GAP150, RAB3GAP150, SPG69, WARBM2, p150 " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008139 25782 RAB3GAP2 http://www.ncbi.nlm.nih.gov/gene/?term=25782 "RAB3-GAP150, RAB3GAP150, SPG69, WARBM2, p150 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008140 257872 Olfr835 http://www.ncbi.nlm.nih.gov/gene/?term=257872 MOR150-3 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008141 257885 Olfr885 http://www.ncbi.nlm.nih.gov/gene/?term=257885 MOR162-12 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008142 25789 TMEM59L http://www.ncbi.nlm.nih.gov/gene/?term=25789 "BSMAP, C19orf4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008143 257906 Olfr293 http://www.ncbi.nlm.nih.gov/gene/?term=257906 MOR221-3 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008144 257914 Olfr663 http://www.ncbi.nlm.nih.gov/gene/?term=257914 MOR40-12 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008145 257919 Olfr467 http://www.ncbi.nlm.nih.gov/gene/?term=257919 "GA_x5J8B7W6B6J-2556603-2556836, MOR204-33P " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008146 257921 Olfr1229 http://www.ncbi.nlm.nih.gov/gene/?term=257921 "MOR233-19, MOR233-22 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008147 257929 Olfr299 http://www.ncbi.nlm.nih.gov/gene/?term=257929 MOR221-2 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008148 25792 CIZ1 http://www.ncbi.nlm.nih.gov/gene/?term=25792 "LSFR1, NP94, ZNF356 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008149 25796 PGLS http://www.ncbi.nlm.nih.gov/gene/?term=25796 "6PGL, HEL-S-304 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008150 25796 PGLS http://www.ncbi.nlm.nih.gov/gene/?term=25796 "6PGL, HEL-S-304 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008151 257979 Olfr1281 http://www.ncbi.nlm.nih.gov/gene/?term=257979 "MOR248-14P, MOR248-18 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008152 25798 BRI3 http://www.ncbi.nlm.nih.gov/gene/?term=25798 I3 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008153 25799 ZNF324 http://www.ncbi.nlm.nih.gov/gene/?term=25799 "ZF5128, ZNF324A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008154 25799 ZNF324 http://www.ncbi.nlm.nih.gov/gene/?term=25799 "ZF5128A, ZNF324 " mRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00008155 25800 SLC39A6 http://www.ncbi.nlm.nih.gov/gene/?term=25800 "LIV-1, ZIP6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008156 25800 SLC39A6 http://www.ncbi.nlm.nih.gov/gene/?term=25800 "LIV-1, ZIP6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008157 258010 SVIP http://www.ncbi.nlm.nih.gov/gene/?term=258010 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008158 258010 SVIP http://www.ncbi.nlm.nih.gov/gene/?term=258010 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008159 25801 GCA http://www.ncbi.nlm.nih.gov/gene/?term=25801 GCL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008160 25804 LSM4 http://www.ncbi.nlm.nih.gov/gene/?term=25804 "GRP, YER112W " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008161 25804 LSM4 http://www.ncbi.nlm.nih.gov/gene/?term=25804 "GRP, YER112W " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008162 25805 BAMBI http://www.ncbi.nlm.nih.gov/gene/?term=25805 NMA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008163 25807 RHBDD3 http://www.ncbi.nlm.nih.gov/gene/?term=25807 "C22orf3, HS984G1A, PTAG " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008164 2580 GAK http://www.ncbi.nlm.nih.gov/gene/?term=2580 "DNAJ26, DNAJC26 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008165 2580 GAK http://www.ncbi.nlm.nih.gov/gene/?term=2580 "DNAJ26, DNAJC26 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008166 25813 SAMM50 http://www.ncbi.nlm.nih.gov/gene/?term=25813 "CGI-51, OMP85, SAM50, TOB55, TRG-3, YNL026W " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008167 25813 SAMM50 http://www.ncbi.nlm.nih.gov/gene/?term=25813 "CGI-51, OMP85, SAM50, TOB55, TRG-3, YNL026W " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008168 25814 ATXN10 http://www.ncbi.nlm.nih.gov/gene/?term=25814 "E46L, HUMEEP, SCA10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008169 25814 ATXN10 http://www.ncbi.nlm.nih.gov/gene/?term=25814 "E46L, HUMEEP, SCA10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008170 25814 ATXN10 http://www.ncbi.nlm.nih.gov/gene/?term=25814 "E46L, HUMEEP, SCA10 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008171 258163 Olfr504 http://www.ncbi.nlm.nih.gov/gene/?term=258163 "MOR40-15, MOR40-7P " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008172 25816 TNFAIP8 http://www.ncbi.nlm.nih.gov/gene/?term=25816 "GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008173 25816 TNFAIP8 http://www.ncbi.nlm.nih.gov/gene/?term=25816 "GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008174 25816 TNFAIP8 http://www.ncbi.nlm.nih.gov/gene/?term=25816 "GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008175 2581 GALC http://www.ncbi.nlm.nih.gov/gene/?term=2581 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008176 25820 ARIH1 http://www.ncbi.nlm.nih.gov/gene/?term=25820 "ARI, HARI, HHARI, UBCH7BP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008177 25820 ARIH1 http://www.ncbi.nlm.nih.gov/gene/?term=25820 "ARI, HARI, HHARI, UBCH7BP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008178 25820 ARIH1 http://www.ncbi.nlm.nih.gov/gene/?term=25820 "ARI, HARI, HHARI, UBCH7BP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008179 25821 MTO1 http://www.ncbi.nlm.nih.gov/gene/?term=25821 "CGI-02, COXPD10 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008180 258238 Olfr417 http://www.ncbi.nlm.nih.gov/gene/?term=258238 "GA_x5J8B7W3B3M-312879-313274, GA_x6K02T2P20D-20787051-20786119, MOR267-11 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008181 25824 PRDX5 http://www.ncbi.nlm.nih.gov/gene/?term=25824 "ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, SBBI10, prx-V " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008182 25824 PRDX5 http://www.ncbi.nlm.nih.gov/gene/?term=25824 "ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, SBBI10, prx-V " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008183 25824 PRDX5 http://www.ncbi.nlm.nih.gov/gene/?term=25824 "ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, SBBI10, prx-V " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008184 25825 BACE2 http://www.ncbi.nlm.nih.gov/gene/?term=25825 "AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008185 25826 SNORD82 http://www.ncbi.nlm.nih.gov/gene/?term=25826 "RNU82, U82, Z25 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008186 25826 SNORD82 http://www.ncbi.nlm.nih.gov/gene/?term=25826 "RNU82, U82, Z25 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008187 25828 TXN2 http://www.ncbi.nlm.nih.gov/gene/?term=25828 "COXPD29, MT-TRX, MTRX, TRX2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008188 2582 GALE http://www.ncbi.nlm.nih.gov/gene/?term=2582 SDR1E1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008189 2582 GALE http://www.ncbi.nlm.nih.gov/gene/?term=2582 SDR1E1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008190 25830 SULT4A1 http://www.ncbi.nlm.nih.gov/gene/?term=25830 "BR-STL-1, BRSTL1, DJ388M5.3, NST, SULTX3, hBR-STL-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008191 25831 HECTD1 http://www.ncbi.nlm.nih.gov/gene/?term=25831 EULIR mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008192 25831 HECTD1 http://www.ncbi.nlm.nih.gov/gene/?term=25831 EULIR mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008193 258320 Olfr1232 http://www.ncbi.nlm.nih.gov/gene/?term=258320 MOR233-18 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008194 258329 Olfr135 http://www.ncbi.nlm.nih.gov/gene/?term=258329 MOR256-48 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008195 258336 Olfr77 http://www.ncbi.nlm.nih.gov/gene/?term=258336 "18A, MOR143-1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008196 25833 POU2F3 http://www.ncbi.nlm.nih.gov/gene/?term=25833 "Epoc-1, OCT-11, OCT11, OTF-11, PLA-1, PLA1, Skn-1a " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008197 25833 POU2F3 http://www.ncbi.nlm.nih.gov/gene/?term=25833 "Epoc-1, OCT-11, OCT11, OTF-11, PLA-1, PLA1, Skn-1a " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008198 258378 Olfr593 http://www.ncbi.nlm.nih.gov/gene/?term=258378 MOR24-2 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008199 258388 Olfr1279 http://www.ncbi.nlm.nih.gov/gene/?term=258388 MOR245-12 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008200 258398 Olfr1295 http://www.ncbi.nlm.nih.gov/gene/?term=258398 MOR248-10 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008201 25839 COG4 http://www.ncbi.nlm.nih.gov/gene/?term=25839 "CDG2J, COD1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008202 2583 B4GALNT1 http://www.ncbi.nlm.nih.gov/gene/?term=2583 "GALGT, GALNACT, GalNAc-T, SPG26 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008203 258402 Olfr1079 http://www.ncbi.nlm.nih.gov/gene/?term=258402 MOR189-1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008204 25840 METTL7A http://www.ncbi.nlm.nih.gov/gene/?term=25840 AAM-B mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008205 25842 ASF1A http://www.ncbi.nlm.nih.gov/gene/?term=25842 "CGI-98, CIA, HSPC146 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008206 25842 ASF1A http://www.ncbi.nlm.nih.gov/gene/?term=25842 "CGI-98, CIA, HSPC146 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008207 258430 Olfr938 http://www.ncbi.nlm.nih.gov/gene/?term=258430 MOR171-25 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008208 25843 MOB4 http://www.ncbi.nlm.nih.gov/gene/?term=25843 "2C4D, CGI-95, MOB1, MOB3, MOBKL3, PHOCN, PREI3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008209 25843 MOB4 http://www.ncbi.nlm.nih.gov/gene/?term=25843 "2C4D, CGI-95, MOB1, MOB3, MOBKL3, PHOCN, PREI3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008210 25843 MOB4 http://www.ncbi.nlm.nih.gov/gene/?term=25843 "2C4D, CGI-95, MOB1, MOB3, MOBKL3, PHOCN, PREI3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008211 25844 YIPF3 http://www.ncbi.nlm.nih.gov/gene/?term=25844 "C6orf109, FinGER3, KLIP1, dJ337H4.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008212 25847 ANAPC13 http://www.ncbi.nlm.nih.gov/gene/?term=25847 "APC13, SWM1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008213 25847 ANAPC13 http://www.ncbi.nlm.nih.gov/gene/?term=25847 "APC13, SWM1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008214 258487 Olfr722 http://www.ncbi.nlm.nih.gov/gene/?term=258487 MOR241-3 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008215 2584 GALK1 http://www.ncbi.nlm.nih.gov/gene/?term=2584 "GALK, GK1, HEL-S-19 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008216 25850 ZNF345 http://www.ncbi.nlm.nih.gov/gene/?term=25850 HZF10 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008217 25850 ZNF345 http://www.ncbi.nlm.nih.gov/gene/?term=25850 HZF10 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008218 25852 ARMC8 http://www.ncbi.nlm.nih.gov/gene/?term=25852 "GID5, HSPC056, S863-2, VID28 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008219 258534 Olfr1361 http://www.ncbi.nlm.nih.gov/gene/?term=258534 MOR256-12 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008220 25853 DCAF12 http://www.ncbi.nlm.nih.gov/gene/?term=25853 "CT102, KIAA1892, TCC52, WDR40A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008221 25853 DCAF12 http://www.ncbi.nlm.nih.gov/gene/?term=25853 "CT102, KIAA1892, TCC52, WDR40A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008222 258549 Olfr798 http://www.ncbi.nlm.nih.gov/gene/?term=258549 MOR108-1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008223 25854 FAM149A http://www.ncbi.nlm.nih.gov/gene/?term=25854 "MST119, MSTP119 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008224 25855 BRMS1 http://www.ncbi.nlm.nih.gov/gene/?term=25855 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008225 25855 BRMS1 http://www.ncbi.nlm.nih.gov/gene/?term=25855 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008226 258561 Olfr1012 http://www.ncbi.nlm.nih.gov/gene/?term=258561 MOR213-6 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008227 25858 TEX40 http://www.ncbi.nlm.nih.gov/gene/?term=25858 C11orf20 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008228 258597 Olfr716 http://www.ncbi.nlm.nih.gov/gene/?term=258597 MOR260-2 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008229 2585 GALK2 http://www.ncbi.nlm.nih.gov/gene/?term=2585 GK2 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008230 25861 DFNB31 http://www.ncbi.nlm.nih.gov/gene/?term=25861 "CIP98, PDZD7B, USH2D, WHRN, WI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008231 258632 Olfr1138 http://www.ncbi.nlm.nih.gov/gene/?term=258632 MOR177-8 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008232 258644 Olfr1166 http://www.ncbi.nlm.nih.gov/gene/?term=258644 MOR174-6 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008233 25864 ABHD14A http://www.ncbi.nlm.nih.gov/gene/?term=25864 DORZ1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008234 25865 PRKD2 http://www.ncbi.nlm.nih.gov/gene/?term=25865 "HSPC187, PKD2, nPKC-D2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008235 258675 Olfr1423 http://www.ncbi.nlm.nih.gov/gene/?term=258675 MOR239-3 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008236 258677 Olfr76 http://www.ncbi.nlm.nih.gov/gene/?term=258677 "MOR215-3, V5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008237 258679 Olfr1440 http://www.ncbi.nlm.nih.gov/gene/?term=258679 MOR215-1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008238 258690 Olfr1469 http://www.ncbi.nlm.nih.gov/gene/?term=258690 MOR202-11 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008239 25870 SUMF2 http://www.ncbi.nlm.nih.gov/gene/?term=25870 pFGE mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008240 25870 SUMF2 http://www.ncbi.nlm.nih.gov/gene/?term=25870 pFGE mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008241 25870 SUMF2 http://www.ncbi.nlm.nih.gov/gene/?term=25870 pFGE mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008242 25871 C3orf17 http://www.ncbi.nlm.nih.gov/gene/?term=25871 "NEPRO, NET17 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008243 258720 Olfr516 http://www.ncbi.nlm.nih.gov/gene/?term=258720 MOR268-2 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008244 258736 Olfr1497 http://www.ncbi.nlm.nih.gov/gene/?term=258736 MOR212-1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008245 25873 RPL36 http://www.ncbi.nlm.nih.gov/gene/?term=25873 L36 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008246 25874 MPC2 http://www.ncbi.nlm.nih.gov/gene/?term=25874 BRP44 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008247 25874 MPC2 http://www.ncbi.nlm.nih.gov/gene/?term=25874 BRP44 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008248 258768 Olfr1189 http://www.ncbi.nlm.nih.gov/gene/?term=258768 MOR237-2 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008249 25878 MXRA5 http://www.ncbi.nlm.nih.gov/gene/?term=25878 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008250 25879 DCAF13 http://www.ncbi.nlm.nih.gov/gene/?term=25879 "GM83, HSPC064, WDSOF1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008251 25880 TMEM186 http://www.ncbi.nlm.nih.gov/gene/?term=25880 C16orf51 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008252 25885 POLR1A http://www.ncbi.nlm.nih.gov/gene/?term=25885 "A190, AFDCIN, RPA1, RPA194, RPO1-4, RPO14 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008253 25886 POC1A http://www.ncbi.nlm.nih.gov/gene/?term=25886 "PIX2, SOFT, WDR51A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008254 258886 Olfr1299 http://www.ncbi.nlm.nih.gov/gene/?term=258886 MOR248-8 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008255 258887 Olfr1294 http://www.ncbi.nlm.nih.gov/gene/?term=258887 MOR248-7 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008256 25888 ZNF473 http://www.ncbi.nlm.nih.gov/gene/?term=25888 "HZFP100, ZN473 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008257 258890 Olfr1297 http://www.ncbi.nlm.nih.gov/gene/?term=258890 MOR248-4 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008258 258895 Olfr1216 http://www.ncbi.nlm.nih.gov/gene/?term=258895 MOR233-9 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008259 25893 TRIM58 http://www.ncbi.nlm.nih.gov/gene/?term=25893 BIA2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008260 25894 PLEKHG4 http://www.ncbi.nlm.nih.gov/gene/?term=25894 "ARHGEF44, PRTPHN1, SCA4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008261 258951 Olfr339 http://www.ncbi.nlm.nih.gov/gene/?term=258951 MOR136-3 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008262 258959 Olfr170 http://www.ncbi.nlm.nih.gov/gene/?term=258959 MOR273-2 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008263 25895 METTL21B http://www.ncbi.nlm.nih.gov/gene/?term=25895 FAM119B mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008264 25895 METTL21B http://www.ncbi.nlm.nih.gov/gene/?term=25895 FAM119B mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008265 25896 INTS7 http://www.ncbi.nlm.nih.gov/gene/?term=25896 "C1orf73, INT7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008266 25896 INTS7 http://www.ncbi.nlm.nih.gov/gene/?term=25896 "C1orf73, INT7 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008267 258971 Olfr1243 http://www.ncbi.nlm.nih.gov/gene/?term=258971 MOR231-4 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008268 25897 RNF19A http://www.ncbi.nlm.nih.gov/gene/?term=25897 RNF19 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008269 25898 RCHY1 http://www.ncbi.nlm.nih.gov/gene/?term=25898 "ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008270 25898 RCHY1 http://www.ncbi.nlm.nih.gov/gene/?term=25898 "ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008271 2589 GALNT1 http://www.ncbi.nlm.nih.gov/gene/?term=2589 GALNAC-T1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008272 2589 GALNT1 http://www.ncbi.nlm.nih.gov/gene/?term=2589 GALNAC-T1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008273 2589 GALNT1 http://www.ncbi.nlm.nih.gov/gene/?term=2589 GALNAC-T1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008274 25901 CCDC28A http://www.ncbi.nlm.nih.gov/gene/?term=25901 "C6orf80, CCRL1AP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008275 259026 Olfr378 http://www.ncbi.nlm.nih.gov/gene/?term=259026 MOR135-2 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008276 25902 MTHFD1L http://www.ncbi.nlm.nih.gov/gene/?term=25902 "FTHFSDC1, MTC1THFS, dJ292B18.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008277 25902 MTHFD1L http://www.ncbi.nlm.nih.gov/gene/?term=25902 "FTHFSDC1, MTC1THFS, dJ292B18.2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008278 25904 CNOT10 http://www.ncbi.nlm.nih.gov/gene/?term=25904 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008279 25904 CNOT10 http://www.ncbi.nlm.nih.gov/gene/?term=25904 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008280 25906 ANAPC15 http://www.ncbi.nlm.nih.gov/gene/?term=25906 "APC15, C11orf51, HSPC020 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008281 25906 ANAPC15 http://www.ncbi.nlm.nih.gov/gene/?term=25906 "APC15, C11orf51, HSPC020 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008282 259074 Olfr1352 http://www.ncbi.nlm.nih.gov/gene/?term=259074 MOR139-1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008283 25907 TMEM158 http://www.ncbi.nlm.nih.gov/gene/?term=25907 "BBP, RIS1, p40BBP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008284 2590 GALNT2 http://www.ncbi.nlm.nih.gov/gene/?term=2590 GalNAc-T2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008285 2590 GALNT2 http://www.ncbi.nlm.nih.gov/gene/?term=2590 GalNAc-T2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008286 2590 GALNT2 http://www.ncbi.nlm.nih.gov/gene/?term=2590 GalNAc-T2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008287 259111 Olfr974 http://www.ncbi.nlm.nih.gov/gene/?term=259111 MOR171-1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008288 259112 Olfr979 http://www.ncbi.nlm.nih.gov/gene/?term=259112 MOR223-1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008289 25911 DPCD http://www.ncbi.nlm.nih.gov/gene/?term=25911 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008290 25912 C1orf43 http://www.ncbi.nlm.nih.gov/gene/?term=25912 "HSPC012, NICE-3, NS5ATP4, S863-3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008291 25913 POT1 http://www.ncbi.nlm.nih.gov/gene/?term=25913 "CMM10, GLM9, HPOT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008292 25914 RTTN http://www.ncbi.nlm.nih.gov/gene/?term=25914 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008293 25915 NDUFAF3 http://www.ncbi.nlm.nih.gov/gene/?term=25915 "2P1, C3orf60, E3-3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008294 259173 ALS2CL http://www.ncbi.nlm.nih.gov/gene/?term=259173 RN49018 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008295 25917 THUMPD3 http://www.ncbi.nlm.nih.gov/gene/?term=25917 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008296 25917 THUMPD3 http://www.ncbi.nlm.nih.gov/gene/?term=25917 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008297 259197 NCR3 http://www.ncbi.nlm.nih.gov/gene/?term=259197 "1C7, CD337, LY117, MALS, NKp30 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008298 25920 NELFB http://www.ncbi.nlm.nih.gov/gene/?term=25920 "COBRA1, NELF-B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008299 259215 LY6G6F http://www.ncbi.nlm.nih.gov/gene/?term=259215 "C6orf21, G6f, LY6G6D, NG32 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008300 25921 ZDHHC5 http://www.ncbi.nlm.nih.gov/gene/?term=25921 "DHHC5, ZNF375 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008301 25921 ZDHHC5 http://www.ncbi.nlm.nih.gov/gene/?term=25921 "DHHC5, ZNF375 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008302 259230 SGMS1 http://www.ncbi.nlm.nih.gov/gene/?term=259230 "MOB, MOB1, SMS1, TMEM23, hmob33 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008303 259230 SGMS1 http://www.ncbi.nlm.nih.gov/gene/?term=259230 "MOB, MOB1, SMS1, TMEM23, hmob33 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008304 259230 SGMS1 http://www.ncbi.nlm.nih.gov/gene/?term=259230 "MOB, MOB1, SMS1, TMEM23, hmob33 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008305 25923 ATL3 http://www.ncbi.nlm.nih.gov/gene/?term=25923 HSN1F mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008306 25923 ATL3 http://www.ncbi.nlm.nih.gov/gene/?term=25923 HSN1F mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008307 25925 ZNF521 http://www.ncbi.nlm.nih.gov/gene/?term=25925 "EHZF, Evi3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008308 259266 ASPM http://www.ncbi.nlm.nih.gov/gene/?term=259266 "ASP, Calmbp1, MCPH5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008309 25926 NOL11 http://www.ncbi.nlm.nih.gov/gene/?term=25926 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008310 259279 Tubgcp3 http://www.ncbi.nlm.nih.gov/gene/?term=259279 "GCP3, Spc98p " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008311 259282 BOD1L1 http://www.ncbi.nlm.nih.gov/gene/?term=259282 "BOD1L, FAM44A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008312 259282 BOD1L1 http://www.ncbi.nlm.nih.gov/gene/?term=259282 "BOD1L, FAM44A " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008313 2592 GALT http://www.ncbi.nlm.nih.gov/gene/?term=2592 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008314 2592 GALT http://www.ncbi.nlm.nih.gov/gene/?term=2592 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008315 259300 Ehd2 http://www.ncbi.nlm.nih.gov/gene/?term=259300 "BC027084, C130052H20Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008316 259302 Srgap3 http://www.ncbi.nlm.nih.gov/gene/?term=259302 "AI452337, Arhgap14, D130026O08Rik, Gbi, MEGAP, WRP, mKIAA0411 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008317 25932 CLIC4 http://www.ncbi.nlm.nih.gov/gene/?term=25932 "CLIC4L, H1, MTCLIC, huH1, p64H1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008318 25934 NIPSNAP3A http://www.ncbi.nlm.nih.gov/gene/?term=25934 "HSPC299, NIPSNAP4, TASSC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008319 25936 NSL1 http://www.ncbi.nlm.nih.gov/gene/?term=25936 "C1orf48, DC8, MIS14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008320 25936 NSL1 http://www.ncbi.nlm.nih.gov/gene/?term=25936 "C1orf48, DC8, MIS14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008321 25937 WWTR1 http://www.ncbi.nlm.nih.gov/gene/?term=25937 TAZ mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008322 25937 WWTR1 http://www.ncbi.nlm.nih.gov/gene/?term=25937 TAZ mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008323 2593 GAMT http://www.ncbi.nlm.nih.gov/gene/?term=2593 "CCDS2, HEL-S-20, PIG2, TP53I2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008324 2593 GAMT http://www.ncbi.nlm.nih.gov/gene/?term=2593 "CCDS2, HEL-S-20, PIG2, TP53I2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008325 25940 FAM98A http://www.ncbi.nlm.nih.gov/gene/?term=25940 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008326 25941 TPGS2 http://www.ncbi.nlm.nih.gov/gene/?term=25941 "C18orf10, HMFN0601, L17, PGs2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008327 25942 SIN3A http://www.ncbi.nlm.nih.gov/gene/?term=25942 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008328 25942 SIN3A http://www.ncbi.nlm.nih.gov/gene/?term=25942 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008329 25943 C20orf194 http://www.ncbi.nlm.nih.gov/gene/?term=25943 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008330 25945 NECTIN3 http://www.ncbi.nlm.nih.gov/gene/?term=25945 "CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRL3, PVRR3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008331 25946 ZNF385A http://www.ncbi.nlm.nih.gov/gene/?term=25946 "HZF, RZF, ZFP385, ZNF385 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008332 25948 KBTBD2 http://www.ncbi.nlm.nih.gov/gene/?term=25948 BKLHD1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008333 25948 KBTBD2 http://www.ncbi.nlm.nih.gov/gene/?term=25948 BKLHD1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008334 25949 SYF2 http://www.ncbi.nlm.nih.gov/gene/?term=25949 "CBPIN, NTC31, P29, fSAP29 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008335 25949 SYF2 http://www.ncbi.nlm.nih.gov/gene/?term=25949 "CBPIN, NTC31, P29, fSAP29 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008336 25950 RWDD3 http://www.ncbi.nlm.nih.gov/gene/?term=25950 RSUME mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008337 25950 RWDD3 http://www.ncbi.nlm.nih.gov/gene/?term=25950 RSUME mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008338 25953 PNKD http://www.ncbi.nlm.nih.gov/gene/?term=25953 "BRP17, DYT8, FKSG19, FPD1, KIPP1184, MR-1, MR1, PDC, PKND1, TAHCCP2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008339 25953 PNKD http://www.ncbi.nlm.nih.gov/gene/?term=25953 "BRP17, DYT8, FKSG19, FPD1, KIPP1184, MR-1, MR1, PDC, PKND1, TAHCCP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008340 25957 PNISR http://www.ncbi.nlm.nih.gov/gene/?term=25957 "C6orf111, HSPC306, SFRS18, SRrp130, bA98I9.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008341 25957 PNISR http://www.ncbi.nlm.nih.gov/gene/?term=25957 "C6orf111, HSPC306, SFRS18, SRrp130, bA98I9.2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008342 25959 KANK2 http://www.ncbi.nlm.nih.gov/gene/?term=25959 "ANKRD25, MXRA3, PPKWH, SIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008343 25959 KANK2 http://www.ncbi.nlm.nih.gov/gene/?term=25959 "ANKRD25, MXRA3, PPKWH, SIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008344 25961 NUDT13 http://www.ncbi.nlm.nih.gov/gene/?term=25961 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008345 25963 TMEM87A http://www.ncbi.nlm.nih.gov/gene/?term=25963 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008346 25963 TMEM87A http://www.ncbi.nlm.nih.gov/gene/?term=25963 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008347 25966 C2CD2 http://www.ncbi.nlm.nih.gov/gene/?term=25966 "C21orf25, C21orf258, TMEM24L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008348 25970 SH2B1 http://www.ncbi.nlm.nih.gov/gene/?term=25970 "PSM, SH2B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008349 25972 UNC50 http://www.ncbi.nlm.nih.gov/gene/?term=25972 "GMH1, HSD23, UNCL, URP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008350 25972 UNC50 http://www.ncbi.nlm.nih.gov/gene/?term=25972 "GMH1, HSD23, UNCL, URP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008351 25972 UNC50 http://www.ncbi.nlm.nih.gov/gene/?term=25972 "GMH1, HSD23, UNCL, URP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008352 25973 PARS2 http://www.ncbi.nlm.nih.gov/gene/?term=25973 "MT-PRORS, proRS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008353 25974 MMACHC http://www.ncbi.nlm.nih.gov/gene/?term=25974 cblC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008354 25974 MMACHC http://www.ncbi.nlm.nih.gov/gene/?term=25974 cblC mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008355 25974 MMACHC http://www.ncbi.nlm.nih.gov/gene/?term=25974 cblC mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008356 25976 TIPARP http://www.ncbi.nlm.nih.gov/gene/?term=25976 "ARTD14, PARP7, pART14 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008357 25977 NECAP1 http://www.ncbi.nlm.nih.gov/gene/?term=25977 EIEE21 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008358 25978 CHMP2B http://www.ncbi.nlm.nih.gov/gene/?term=25978 "ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008359 25978 CHMP2B http://www.ncbi.nlm.nih.gov/gene/?term=25978 "ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008360 25978 CHMP2B http://www.ncbi.nlm.nih.gov/gene/?term=25978 "ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008361 25979 DHRS7B http://www.ncbi.nlm.nih.gov/gene/?term=25979 "CGI-93, SDR32C1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008362 25979 DHRS7B http://www.ncbi.nlm.nih.gov/gene/?term=25979 "CGI-93, SDR32C1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008363 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00008364 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 19175411 Ribosome T-cell|SeAx qRT-PCR "Using quantitative real-time RT-PCR we evaluated, whether mRNAs coding for differently located proteins are selectively enriched in one of the two analysed compartments, namely free versus membrane-associated polysomes. We selected genes coding for proteins located in the plasma membrane (GPR137B), secreted proteins (TIC2, IBP2, PAI) and cytosolic proteins (the house keeping genes GAPDH and HMBS). In fact, the distribution of the specific mRNA was as predicted ( Fig. 1): The average ratio of specific mRNA at bound ribosomes versus free ribosomes was 1 ? 4.4 for the housekeeping genes (GAPDH and HMBS) and 13.3 ? 1 for genes coding for membrane-bound or secreted proteins. Ratios for genes coding for cytosolic proteins were always below 0.6 and those for membrane or secreted genes were always above 1. The highest values were observed for PAI in MyLa (57 ? 1) and GPR137B in SeAx (34 ? 1), while the lowest ratios were detected for HMBS (1 ? 55) and GAPDH (1 ? 12) in HuT78. " RLID00008365 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008366 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 22895844 Exosome Colon|Liver|Lung qRT-PCR "When the RNA species within exosomes derived from the three CRC cell lines were examined, the mRNAs of housekeeping genes such as ACTB and GAPDH, the microRNAs such as miR-21, miR-192 and miR-221, and the natural antisense RNAs of LRRC24, MDM2 and CDKN1A genes, were detected. " RLID00008367 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 12923260 Ribosome T-cell line Jurkat Northern blot "In this report, we use multiple cell fractionation protocols, in combination with cDNA microarray, nuclease protection, and Northern blot analyses, to assess the distribution of mRNAs between free and ER-bound ribosomes. We find a broad representation of mRNAs encoding soluble proteins in the ER fraction, with a subset of such mRNAs displaying substantial ER partitioning. In addition, we present evidence that membrane-bound ribosomes engage in the translation of mRNAs encoding soluble proteins. Single-cell in situ hybridization analysis of the subcellular distribution of mRNAs encoding ER-localized and soluble proteins identify two overall patterns of mRNA distribution in the cell-endoplasmic reticular and cytosolic. FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells. " RLID00008368 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 12923260 Ribosome T-cell line Jurkat S1 nuclease protection assays "However, and as depicted in Figure 4 (Cytosol), mRNAs encoding GAPDH and LDH were present in both free and membrane-bound polysomes, and mRNAs encoding Hsp90 displayed a high enrichment in the membrane-bound fraction (75%-97%). Such partitioning of mRNAs to the ER was observed in 15 independent experiments using ER derived from Jurkat and J558 cells alike, thus confirming that mRNAs encoding signal-sequence-bearing proteins and mRNAs encoding cytosolic proteins are present on the ER. " RLID00008369 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 16178658 Mitochondrion HDF cell Fluorescence in situ hybridization "Unexpectedly, we found that both K-ras and GAPDH mRNAs colocalize with mitochondria. Extensive control studies are performed, including the use of fluorescence in-situ hybridization (FISH), negative-control beacons, and the detection of colocalization of 28S ribosomal RNA with the rough endoplasmic reticulum (ER), suggesting that the mRNA localization and colocalization patterns observed in our study are true and specific. " RLID00008370 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 21431749 Cytosol HEK293 cell Northern blot "Similarly, Northern blot analysis of the mRNA composition of the cytosol and membrane fractions show that the cytosol fraction is enriched for mRNAs encoding histone (H3F3A) and GAPDH, whereas the membrane fraction is enriched in mRNAs encoding ER resident proteins, such as GRP94 and calreticulin (Fig. 2 B). " RLID00008371 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 25142066 Endoplasmic reticulum HEK293|HeLa|HDF|J558 cell qRT-PCR "Figure 3: Correlation between paired measurements of the fraction of 18S rRNA and GAPDH mRNA on the ER membrane. Correlation between paired measurements of the fraction of 18S rRNA and GAPDH mRNA on the ER membrane. (A) Ribosome and GAPDH mRNA distributions were determined in the indicated cell lines and in 16 independent experiments conducted with HEK293 cells (B). qPCR array data comparing RNA distribution in cytosol and membrane fractions of HEK293 (C) and J558 (D) cells. Data are represented as a histogram of the fractional value of RNA in the membrane fraction for various cohorts of RNAs. mRNAcyt represent RNAs that encode cytosolic and nucleoplasmic proteins; mRNAsec include RNAs encoding secretory and membrane proteins as well as resident proteins of endomembrane organelles. (?) Mean, (σ) deviation. Data are collected from Figure 3. " RLID00008372 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 25142066 Cytosol HeLa cell|HEK293 cell In situ hybridization "Here, using single molecule RNA fluorescence in situ hybridization and cell fractionation, we have demonstrated that a candidate RNA with an expected cytosolic distribution, GAPDH, does, indeed, reside in close proximity to the ER membrane and, by virtue of its extractability in detergent, can be translated on ER-bound ribosomes. " RLID00008373 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 25142066 Ribosome HEK293|HeLa|HDF|J558 cell qRT-PCR "Figure 3: Correlation between paired measurements of the fraction of 18S rRNA and GAPDH mRNA on the ER membrane. Correlation between paired measurements of the fraction of 18S rRNA and GAPDH mRNA on the ER membrane. (A) Ribosome and GAPDH mRNA distributions were determined in the indicated cell lines and in 16 independent experiments conducted with HEK293 cells (B). qPCR array data comparing RNA distribution in cytosol and membrane fractions of HEK293 (C) and J558 (D) cells. Data are represented as a histogram of the fractional value of RNA in the membrane fraction for various cohorts of RNAs. mRNAcyt represent RNAs that encode cytosolic and nucleoplasmic proteins; mRNAsec include RNAs encoding secretory and membrane proteins as well as resident proteins of endomembrane organelles. (?) Mean, (σ) deviation. Data are collected from Figure 3. " RLID00008374 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 26272916 Endoplasmic reticulum U2OS cell Fluorescence in situ hybridization "To determine whether partial ER association was a general phenomenon for all mRNAs, we next investigated the localization of an mRNA encoding a cytosolic protein, glyceraldehyde 3-phosphate dehydrogenase (GAPDH). We could reproducibly find 15% of the GAPDH puncta in digitonin-extracted cells (Fig. 1A,B). However, in contrast to what we had seen for Sec61b and nesprin-2, most of the GAPDH mRNAs were extracted in cells treated with either HHT, or puromycin+EDTA (Fig. 1), suggesting that the small amount of ER association was mediated by translating ribosomes. Data are collected from Figure 1. " RLID00008375 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008376 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008377 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008378 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 22193719 Cytoplasm Embryonic stem cell qRT-PCR|Microarray "Figure 7: Neuronal lncRNAs act via diverse mechanisms. (A) Quantification of relative expression of lncRNAs in nuclear and cytoplasmic cell fractions. (B) Quantification of changes in hosted miRNAs in response to lncRNA_N2 knockdown. MiRNAs were quantified using Taqman miRNA qPCR. (C-E) RIP of lncRNAs with SUZ12 and REST antibodies. The interaction of HOTAIR with SUZ12 is a known interaction that serves as a positive control (Gupta et al, 2010). * and ** indicate P-values of <0.05 and <0.01, respectively. Data are collected from Figure 7. " RLID00008379 2597 GAPDH http://www.ncbi.nlm.nih.gov/gene/?term=2597 "G3PD, GAPD, HEL-S-162eP " mRNA Homo sapiens 25753659 Cytosol HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00008380 25980 AAR2 http://www.ncbi.nlm.nih.gov/gene/?term=25980 "C20orf4, CGI-23 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008381 25983 NGDN http://www.ncbi.nlm.nih.gov/gene/?term=25983 "C14orf120, CANu1, LCP5, NGD, lpd-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008382 25983 NGDN http://www.ncbi.nlm.nih.gov/gene/?term=25983 "C14orf120, CANu1, LCP5, NGD, lpd-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008383 25983 NGDN http://www.ncbi.nlm.nih.gov/gene/?term=25983 "C14orf120, CANu1, LCP5, NGD, lpd-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008384 25987 TSKU http://www.ncbi.nlm.nih.gov/gene/?term=25987 "E2IG4, LRRC54, TSK " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008385 25988 HINFP http://www.ncbi.nlm.nih.gov/gene/?term=25988 "HiNF-P, MIZF, ZNF743 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008386 25994 HIGD1A http://www.ncbi.nlm.nih.gov/gene/?term=25994 "HIG1, RCF1a " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008387 25994 HIGD1A http://www.ncbi.nlm.nih.gov/gene/?term=25994 "HIG1, RCF1a " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008388 25994 HIGD1A http://www.ncbi.nlm.nih.gov/gene/?term=25994 "HIG1, RCF1a " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008389 25996 REXO2 http://www.ncbi.nlm.nih.gov/gene/?term=25996 "CGI-114, REX2, RFN, SFN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008390 25998 IBTK http://www.ncbi.nlm.nih.gov/gene/?term=25998 "BTBD26, BTKI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008391 25 ABL1 http://www.ncbi.nlm.nih.gov/gene/?term=25 "ABL, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008392 25 ABL1 http://www.ncbi.nlm.nih.gov/gene/?term=25 "ABL, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008393 25 ABL1 http://www.ncbi.nlm.nih.gov/gene/?term=25 "ABL, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008394 26000 TBC1D10B http://www.ncbi.nlm.nih.gov/gene/?term=26000 "EPI64B, FP2461 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008395 26001 RNF167 http://www.ncbi.nlm.nih.gov/gene/?term=26001 "5730408C10Rik, LP2254, RING105 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008396 26003 GORASP2 http://www.ncbi.nlm.nih.gov/gene/?term=26003 "GOLPH6, GRASP55, GRS2, p59 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008397 26005 C2CD3 http://www.ncbi.nlm.nih.gov/gene/?term=26005 OFD14 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008398 26007 TKFC http://www.ncbi.nlm.nih.gov/gene/?term=26007 "DAK, NET45 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008399 26007 TKFC http://www.ncbi.nlm.nih.gov/gene/?term=26007 "DAK, NET45 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008400 26009 ZZZ3 http://www.ncbi.nlm.nih.gov/gene/?term=26009 ATAC1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008401 26010 SPATS2L http://www.ncbi.nlm.nih.gov/gene/?term=26010 "DNAPTP6, SGNP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008402 26010 SPATS2L http://www.ncbi.nlm.nih.gov/gene/?term=26010 "DNAPTP6, SGNP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008403 26011 TENM4 http://www.ncbi.nlm.nih.gov/gene/?term=26011 "Doc4, ETM5, ODZ4, TNM4, Ten-M4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008404 26012 NSMF http://www.ncbi.nlm.nih.gov/gene/?term=26012 "HH9, NELF " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008405 26017 FAM32A http://www.ncbi.nlm.nih.gov/gene/?term=26017 "OTAG-12, OTAG12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008406 26018 LRIG1 http://www.ncbi.nlm.nih.gov/gene/?term=26018 "LIG-1, LIG1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008407 26019 UPF2 http://www.ncbi.nlm.nih.gov/gene/?term=26019 "HUPF2, RENT2, smg-3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008408 26019 UPF2 http://www.ncbi.nlm.nih.gov/gene/?term=26019 "HUPF2, RENT2, smg-3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008409 26020 LRP10 http://www.ncbi.nlm.nih.gov/gene/?term=26020 "LRP9, MST087, MSTP087 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008410 260293 CYP4X1 http://www.ncbi.nlm.nih.gov/gene/?term=260293 CYPIVX1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008411 260294 NSUN5P2 http://www.ncbi.nlm.nih.gov/gene/?term=260294 "NOL1R2, NSUN5C, WBSCR20B, WBSCR20C " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008412 26030 PLEKHG3 http://www.ncbi.nlm.nih.gov/gene/?term=26030 "ARHGEF43, KIAA0599 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008413 26031 OSBPL3 http://www.ncbi.nlm.nih.gov/gene/?term=26031 "ORP-3, ORP3, OSBP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008414 26032 SUSD5 http://www.ncbi.nlm.nih.gov/gene/?term=26032 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008415 26034 IPCEF1 http://www.ncbi.nlm.nih.gov/gene/?term=26034 PIP3-E mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008416 26034 IPCEF1 http://www.ncbi.nlm.nih.gov/gene/?term=26034 PIP3-E mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008417 26035 GLCE http://www.ncbi.nlm.nih.gov/gene/?term=26035 HSEPI mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008418 26037 SIPA1L1 http://www.ncbi.nlm.nih.gov/gene/?term=26037 E6TP1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008419 260425 MAGI3 http://www.ncbi.nlm.nih.gov/gene/?term=260425 "MAGI-3, dJ730K3.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008420 26046 LTN1 http://www.ncbi.nlm.nih.gov/gene/?term=26046 "C21orf10, C21orf98, RNF160, ZNF294 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008421 26047 CNTNAP2 http://www.ncbi.nlm.nih.gov/gene/?term=26047 "AUTS15, CASPR2, CDFE, NRXN4, PTHSL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008422 26048 ZNF500 http://www.ncbi.nlm.nih.gov/gene/?term=26048 "ZKSCAN18, ZSCAN50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008423 26049 FAM169A http://www.ncbi.nlm.nih.gov/gene/?term=26049 SLAP75 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008424 26051 PPP1R16B http://www.ncbi.nlm.nih.gov/gene/?term=26051 "ANKRD4, TIMAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008425 26054 SENP6 http://www.ncbi.nlm.nih.gov/gene/?term=26054 "SSP1, SUSP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008426 26054 SENP6 http://www.ncbi.nlm.nih.gov/gene/?term=26054 "SSP1, SUSP1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008427 26054 SENP6 http://www.ncbi.nlm.nih.gov/gene/?term=26054 "SSP1, SUSP1 " mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00008428 26056 RAB11FIP5 http://www.ncbi.nlm.nih.gov/gene/?term=26056 "GAF1, RIP11, pp75 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008429 26056 RAB11FIP5 http://www.ncbi.nlm.nih.gov/gene/?term=26056 "GAF1, RIP11, pp75 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008430 26057 ANKRD17 http://www.ncbi.nlm.nih.gov/gene/?term=26057 "GTAR, MASK2, NY-BR-16 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008431 26057 ANKRD17 http://www.ncbi.nlm.nih.gov/gene/?term=26057 "GTAR, MASK2, NY-BR-16 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008432 26057 ANKRD17 http://www.ncbi.nlm.nih.gov/gene/?term=26057 "GTAR, MASK2, NY-BR-16 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008433 26058 GIGYF2 http://www.ncbi.nlm.nih.gov/gene/?term=26058 "GYF2, PARK11, PERQ2, PERQ3, TNRC15 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008434 26060 APPL1 http://www.ncbi.nlm.nih.gov/gene/?term=26060 "APPL, DIP13alpha, MODY14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008435 26060 APPL1 http://www.ncbi.nlm.nih.gov/gene/?term=26060 "APPL, DIP13alpha, MODY14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008436 26060 APPL1 http://www.ncbi.nlm.nih.gov/gene/?term=26060 "APPL, DIP13alpha, MODY14 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008437 26060 APPL1 http://www.ncbi.nlm.nih.gov/gene/?term=26060 "APPL, DIP13alpha, MODY14 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008438 26060 APPL1 http://www.ncbi.nlm.nih.gov/gene/?term=26060 "APPL, DIP13alpha, MODY14 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008439 26061 HACL1 http://www.ncbi.nlm.nih.gov/gene/?term=26061 "2-HPCL, HPCL, HPCL2, PHYH2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008440 26063 DECR2 http://www.ncbi.nlm.nih.gov/gene/?term=26063 "PDCR, SDR17C1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008441 26063 DECR2 http://www.ncbi.nlm.nih.gov/gene/?term=26063 "PDCR, SDR17C1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008442 26064 RAI14 http://www.ncbi.nlm.nih.gov/gene/?term=26064 "NORPEG, RAI13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008443 26064 RAI14 http://www.ncbi.nlm.nih.gov/gene/?term=26064 "NORPEG, RAI13 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008444 26065 LSM14A http://www.ncbi.nlm.nih.gov/gene/?term=26065 "C19orf13, FAM61A, RAP55, RAP55A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008445 26067080 vas http://www.ncbi.nlm.nih.gov/gene/?term=26067080 "Dmel_CG46283, BG:DS00929.14, CG3506, CG43081, CG46283, DmRH25, Dmel\CG46283, Dmel_CG33678, Dmel_CG3506, Dmel_CG43081, EP(2)0812, VAS, VASA, Vas, Vasa, cgt, fs(2)ltoRJ36 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00008446 26073 POLDIP2 http://www.ncbi.nlm.nih.gov/gene/?term=26073 "PDIP38, POLD4, p38 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008447 26073 POLDIP2 http://www.ncbi.nlm.nih.gov/gene/?term=26073 "PDIP38, POLD4, p38 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008448 26085 KLK13 http://www.ncbi.nlm.nih.gov/gene/?term=26085 "KLK-L4, KLKL4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008449 26086 GPSM1 http://www.ncbi.nlm.nih.gov/gene/?term=26086 AGS3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008450 26090 ABHD12 http://www.ncbi.nlm.nih.gov/gene/?term=26090 "ABHD12A, BEM46L2, C20orf22, PHARC, dJ965G21.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008451 26091 HERC4 http://www.ncbi.nlm.nih.gov/gene/?term=26091 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008452 26091 HERC4 http://www.ncbi.nlm.nih.gov/gene/?term=26091 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008453 26092 TOR1AIP1 http://www.ncbi.nlm.nih.gov/gene/?term=26092 "LAP1, LAP1B " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008454 26097 CHTOP http://www.ncbi.nlm.nih.gov/gene/?term=26097 "C1orf77, FL-SRAG, FOP, SRAG, SRAG-3, SRAG-5, pp7704 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008455 26097 CHTOP http://www.ncbi.nlm.nih.gov/gene/?term=26097 "C1orf77, FL-SRAG, FOP, SRAG, SRAG-3, SRAG-5, pp7704 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008456 26098 EDRF1 http://www.ncbi.nlm.nih.gov/gene/?term=26098 C10orf137 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008457 26099 SZRD1 http://www.ncbi.nlm.nih.gov/gene/?term=26099 C1orf144 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008458 26099 SZRD1 http://www.ncbi.nlm.nih.gov/gene/?term=26099 C1orf144 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008459 26100 WIPI2 http://www.ncbi.nlm.nih.gov/gene/?term=26100 "ATG18B, Atg21, CGI-50, WIPI-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008460 26112 CCDC69 http://www.ncbi.nlm.nih.gov/gene/?term=26112 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008461 26112 CCDC69 http://www.ncbi.nlm.nih.gov/gene/?term=26112 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008462 26115 TANC2 http://www.ncbi.nlm.nih.gov/gene/?term=26115 "ROLSA, rols " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008463 26118 WSB1 http://www.ncbi.nlm.nih.gov/gene/?term=26118 "SWIP1, WSB-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008464 26118 WSB1 http://www.ncbi.nlm.nih.gov/gene/?term=26118 "SWIP1, WSB-1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008465 26119 LDLRAP1 http://www.ncbi.nlm.nih.gov/gene/?term=26119 "ARH, ARH1, ARH2, FHCB1, FHCB2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008466 26121 PRPF31 http://www.ncbi.nlm.nih.gov/gene/?term=26121 "NY-BR-99, PRP31, RP11, SNRNP61 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008467 26121 PRPF31 http://www.ncbi.nlm.nih.gov/gene/?term=26121 "NY-BR-99, PRP31, RP11, SNRNP61 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008468 26122 EPC2 http://www.ncbi.nlm.nih.gov/gene/?term=26122 EPC-LIKE mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008469 26123 TCTN3 http://www.ncbi.nlm.nih.gov/gene/?term=26123 "C10orf61, JBTS18, OFD4, TECT3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008470 26123 TCTN3 http://www.ncbi.nlm.nih.gov/gene/?term=26123 "C10orf61, JBTS18, OFD4, TECT3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008471 26127 FGFR1OP2 http://www.ncbi.nlm.nih.gov/gene/?term=26127 "HSPC123-like, WIT3.0 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008472 26127 FGFR1OP2 http://www.ncbi.nlm.nih.gov/gene/?term=26127 "HSPC123-like, WIT3.0 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008473 26127 FGFR1OP2 http://www.ncbi.nlm.nih.gov/gene/?term=26127 "HSPC123-like, WIT3.0 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008474 26130 GAPVD1 http://www.ncbi.nlm.nih.gov/gene/?term=26130 "GAPEX5, GAPex-5, RAP6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008475 26133 TRPC4AP http://www.ncbi.nlm.nih.gov/gene/?term=26133 "C20orf188, PPP1R158, TRRP4AP, TRUSS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008476 26135 SERBP1 http://www.ncbi.nlm.nih.gov/gene/?term=26135 "CGI-55, CHD3IP, HABP4L, PAI-RBP1, PAIRBP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008477 26135 SERBP1 http://www.ncbi.nlm.nih.gov/gene/?term=26135 "CGI-55, CHD3IP, HABP4L, PAI-RBP1, PAIRBP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008478 26135 SERBP1 http://www.ncbi.nlm.nih.gov/gene/?term=26135 "CGI-55, CHD3IP, HABP4L, PAI-RBP1, PAIRBP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008479 26135 SERBP1 http://www.ncbi.nlm.nih.gov/gene/?term=26135 "CGI-55, CHD3IP, HABP4L, PAI-RBP1, PAIRBP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008480 26135 SERBP1 http://www.ncbi.nlm.nih.gov/gene/?term=26135 "CGI-55, CHD3IP, HABP4L, PAI-RBP1, PAIRBP1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008481 26136 TES http://www.ncbi.nlm.nih.gov/gene/?term=26136 "TESS, TESS-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008482 26136 TES http://www.ncbi.nlm.nih.gov/gene/?term=26136 "TESSS-2, TES " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008483 26136 TES http://www.ncbi.nlm.nih.gov/gene/?term=26136 "TESSS-2, TES " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008484 26136 TES http://www.ncbi.nlm.nih.gov/gene/?term=26136 "TESSS-2, TES " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008485 26145 IRF2BP1 http://www.ncbi.nlm.nih.gov/gene/?term=26145 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008486 26146 TRAF3IP1 http://www.ncbi.nlm.nih.gov/gene/?term=26146 "IFT54, MIP-T3, MIPT3, SLSN9 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008487 26147 PHF19 http://www.ncbi.nlm.nih.gov/gene/?term=26147 "MTF2L1, PCL3, TDRD19B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008488 26152 ZNF337 http://www.ncbi.nlm.nih.gov/gene/?term=26152 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008489 26153 KIF26A http://www.ncbi.nlm.nih.gov/gene/?term=26153 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008490 26155 NOC2L http://www.ncbi.nlm.nih.gov/gene/?term=26155 "NET15, NET7, NIR, PPP1R112 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008491 26155 NOC2L http://www.ncbi.nlm.nih.gov/gene/?term=26155 "NET15, NET7, NIR, PPP1R112 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008492 26156 RSL1D1 http://www.ncbi.nlm.nih.gov/gene/?term=26156 "CSIG, L12, PBK1, UTP30 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008493 26164 MTG2 http://www.ncbi.nlm.nih.gov/gene/?term=26164 "GTPBP5, ObgH1, dJ1005F21.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008494 26166 RGS22 http://www.ncbi.nlm.nih.gov/gene/?term=26166 "CT145, PRTD-NY2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008495 26166 RGS22 http://www.ncbi.nlm.nih.gov/gene/?term=26166 "CT145, PRTD-NY2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008496 26167 PCDHB5 http://www.ncbi.nlm.nih.gov/gene/?term=26167 PCDH-BETA5 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008497 26168 SENP3 http://www.ncbi.nlm.nih.gov/gene/?term=26168 "SMT3IP1, SSP3, Ulp1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008498 26168 SENP3 http://www.ncbi.nlm.nih.gov/gene/?term=26168 "SMT3IP1, SSP3, Ulp1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008499 261726 TIPRL http://www.ncbi.nlm.nih.gov/gene/?term=261726 "TIP, TIP41 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008500 261729 STEAP2 http://www.ncbi.nlm.nih.gov/gene/?term=261729 "IPCA1, PCANAP1, PUMPCn, STAMP1, STMP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008501 261729 STEAP2 http://www.ncbi.nlm.nih.gov/gene/?term=261729 "IPCA1, PCANAP1, PUMPCn, STAMP1, STMP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008502 261734 NPHP4 http://www.ncbi.nlm.nih.gov/gene/?term=261734 "POC10, SLSN4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008503 26173 INTS1 http://www.ncbi.nlm.nih.gov/gene/?term=26173 "INT1, NET28 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008504 26173 INTS1 http://www.ncbi.nlm.nih.gov/gene/?term=26173 "INT1, NET28 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008505 26175 TMEM251 http://www.ncbi.nlm.nih.gov/gene/?term=26175 C14orf109 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008506 2617 GARS http://www.ncbi.nlm.nih.gov/gene/?term=2617 "CMT2D, DSMAV, GlyRS, HMN5, SMAD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008507 2617 GARS http://www.ncbi.nlm.nih.gov/gene/?term=2617 "CMT2D, DSMAV, GlyRS, HMN5, SMAD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008508 2617 GARS http://www.ncbi.nlm.nih.gov/gene/?term=2617 "CMT2D, DSMAV, GlyRS, HMN5, SMAD1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008509 2618 GART http://www.ncbi.nlm.nih.gov/gene/?term=2618 "AIRS, GARS, GARTF, PAIS, PGFT, PRGS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008510 2618 GART http://www.ncbi.nlm.nih.gov/gene/?term=2618 "AIRS, GARSF, PAIS, PGFT, PRGS, GART " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008511 2618 GART http://www.ncbi.nlm.nih.gov/gene/?term=2618 "AIRS, GARSF, PAIS, PGFT, PRGS, GART " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008512 2618 GART http://www.ncbi.nlm.nih.gov/gene/?term=2618 "AIRS, GARSF, PAIS, PGFT, PRGS, GART " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008513 2618 GART http://www.ncbi.nlm.nih.gov/gene/?term=2618 "AIRS, GARSF, PAIS, PGFT, PRGS, GART " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008514 26190 FBXW2 http://www.ncbi.nlm.nih.gov/gene/?term=26190 "FBW2, Fwd2, Md6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008515 26190 FBXW2 http://www.ncbi.nlm.nih.gov/gene/?term=26190 "FBW2, Fwd2, Md6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008516 26190 FBXW2 http://www.ncbi.nlm.nih.gov/gene/?term=26190 "FBW2, Fwd2, Md6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008517 26190 FBXW2 http://www.ncbi.nlm.nih.gov/gene/?term=26190 "FBW2, Fwd2, Md6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008518 26193 mt-Nd1 http://www.ncbi.nlm.nih.gov/gene/?term=26193 ND1 mRNA Rattus norvegicus 23487039 Cell body Hippocampus In situ hybridization "As expected, in situ signals of Nd1 mRNA showed a particular pattern and Nd1 mRNAs were strongly colocalized with Dcp1a-bodies in both the cell bodies and the dendrites (supplementary material Fig. S6C). Intriguingly, the neuronal activity released P-body-bound Nd1 and Arp2 mRNAs, and consequently reversed the decrease of F-actin, which are induced by expression of Dcp1a, in the dendrites. " RLID00008519 26193 mt-Nd1 http://www.ncbi.nlm.nih.gov/gene/?term=26193 ND1 mRNA Rattus norvegicus 23487039 Dendrite Hippocampus In situ hybridization "As expected, in situ signals of Nd1 mRNA showed a particular pattern and Nd1 mRNAs were strongly colocalized with Dcp1a-bodies in both the cell bodies and the dendrites (supplementary material Fig. S6C). Intriguingly, the neuronal activity released P-body-bound Nd1 and Arp2 mRNAs, and consequently reversed the decrease of F-actin, which are induced by expression of Dcp1a, in the dendrites. " RLID00008520 26204 mt-Co3 http://www.ncbi.nlm.nih.gov/gene/?term=26204 COX3 mRNA Rattus norvegicus 8726358 Mitochondrion Liver In situ hybridization "These ratios showed that the mRNAs for argininosuccinate synthetase and argininosuccinate lyase were located next to the cytoplasmic side of the mitochondrial membrane and in the nearby endoplasmic reticulum. These data show that ASL mRNA is preferentially located at the mitochondrial outer membrane and in the ER. Thus,ASS mRNA, likeASL mRNA, is preferentially located at the mitochondrial outer membrane and in the ER. This suggests that COIII mRNA is actually predominantly associated with those portions of the inner membrane which lie at the mitochondrial perimeter rather than along the cristae. " RLID00008521 26205 GMEB2 http://www.ncbi.nlm.nih.gov/gene/?term=26205 "GMEB-2, P79PIF, PIF79 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008522 26207 PITPNC1 http://www.ncbi.nlm.nih.gov/gene/?term=26207 "M-RDGB-beta, MRDGBbeta, RDGB-BETA, RDGBB, RDGBB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008523 26207 PITPNC1 http://www.ncbi.nlm.nih.gov/gene/?term=26207 "M-RDGB-beta, MRDGBbeta, RDGB-BETA, RDGBB, RDGBB1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008524 2620 GAS2 http://www.ncbi.nlm.nih.gov/gene/?term=2620 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008525 2621 GAS6 http://www.ncbi.nlm.nih.gov/gene/?term=2621 "AXLLG, AXSF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008526 2621 GAS6 http://www.ncbi.nlm.nih.gov/gene/?term=2621 "AXLLG, AXSF " mRNA Homo sapiens 25630241 Cytoplasm Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00008527 2621 GAS6 http://www.ncbi.nlm.nih.gov/gene/?term=2621 "AXLLG, AXSF " mRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00008528 26224 FBXL3 http://www.ncbi.nlm.nih.gov/gene/?term=26224 "FBL3, FBL3AA, FBXL3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008529 26225 ARL5A http://www.ncbi.nlm.nih.gov/gene/?term=26225 "ARFLP5, ARL5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008530 26227 PHGDH http://www.ncbi.nlm.nih.gov/gene/?term=26227 "3-PGDH, 3PGDH, HEL-S-113, NLS, NLS1, PDG, PGAD, PGD, PGDHD, SERA, PHGDH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008531 26229 B3GAT3 http://www.ncbi.nlm.nih.gov/gene/?term=26229 "GLCATI, glcUAT-I " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008532 26229 B3GAT3 http://www.ncbi.nlm.nih.gov/gene/?term=26229 "GLCATI, glcUAT-I " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008533 2622 GAS8 http://www.ncbi.nlm.nih.gov/gene/?term=2622 "CILD33, DRC4, GAS11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008534 26230 TIAM2 http://www.ncbi.nlm.nih.gov/gene/?term=26230 "STEF, TIAM-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008535 26233 FBXL6 http://www.ncbi.nlm.nih.gov/gene/?term=26233 "FBL6, FBL6A, PP14630 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008536 26235 FBXL4 http://www.ncbi.nlm.nih.gov/gene/?term=26235 "FBL4, FBL5, MTDPS13 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008537 2623 GATA1 http://www.ncbi.nlm.nih.gov/gene/?term=2623 "ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008538 26249 KLHL3 http://www.ncbi.nlm.nih.gov/gene/?term=26249 PHA2D mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008539 2624 GATA2 http://www.ncbi.nlm.nih.gov/gene/?term=2624 "DCML, IMD21, MONOMAC, NFE1B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008540 26258 BLOC1S6 http://www.ncbi.nlm.nih.gov/gene/?term=26258 "BLOS6, HPS9, PA, PALLID, PLDN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008541 26258 BLOC1S6 http://www.ncbi.nlm.nih.gov/gene/?term=26258 "BLOS6, HPS9, PA, PALLID, PLDN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008542 26258 BLOC1S6 http://www.ncbi.nlm.nih.gov/gene/?term=26258 "BLOS6, HPS9, PA, PALLID, PLDN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008543 26259 FBXW8 http://www.ncbi.nlm.nih.gov/gene/?term=26259 "FBW6, FBW8, FBX29, FBXO29, FBXW6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008544 26259 FBXW8 http://www.ncbi.nlm.nih.gov/gene/?term=26259 "FBW6, FBW8, FBX29, FBXO29, FBXW6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008545 26259 FBXW8 http://www.ncbi.nlm.nih.gov/gene/?term=26259 "FBW6, FBW8, FBX29, FBXO29, FBXW6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008546 2625 GATA3 http://www.ncbi.nlm.nih.gov/gene/?term=2625 "HDR, HDRS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008547 26260 FBXO25 http://www.ncbi.nlm.nih.gov/gene/?term=26260 FBX25 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008548 26262 TSPAN17 http://www.ncbi.nlm.nih.gov/gene/?term=26262 "FBX23, FBXO23, TM4SF17 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008549 26262 TSPAN17 http://www.ncbi.nlm.nih.gov/gene/?term=26262 "FBX23, FBXO23, TM4SF17 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008550 26263 FBXO22 http://www.ncbi.nlm.nih.gov/gene/?term=26263 "FBX22, FISTC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008551 26263 FBXO22 http://www.ncbi.nlm.nih.gov/gene/?term=26263 "FBX22, FISTC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008552 26267 FBXO10 http://www.ncbi.nlm.nih.gov/gene/?term=26267 "FBX10, PRMT11 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008553 26268 FBXO9 http://www.ncbi.nlm.nih.gov/gene/?term=26268 "FBX9, NY-REN-57, VCIA1, dJ341E18.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008554 26268 FBXO9 http://www.ncbi.nlm.nih.gov/gene/?term=26268 "FBX9, NY-REN-57, VCIA1, dJ341E18.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008555 26269 FBXO8 http://www.ncbi.nlm.nih.gov/gene/?term=26269 "DC10, FBS, FBX8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008556 26269 FBXO8 http://www.ncbi.nlm.nih.gov/gene/?term=26269 "DC10, FBS, FBX8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008557 26270 FBXO6 http://www.ncbi.nlm.nih.gov/gene/?term=26270 "FBG2, FBS2, FBX6, Fbx6b " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008558 26271 FBXO5 http://www.ncbi.nlm.nih.gov/gene/?term=26271 "EMI1, FBX5, Fbxo31 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008559 26272 FBXO4 http://www.ncbi.nlm.nih.gov/gene/?term=26272 FBX4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008560 26272 FBXO4 http://www.ncbi.nlm.nih.gov/gene/?term=26272 FBX4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008561 26273 FBXO3 http://www.ncbi.nlm.nih.gov/gene/?term=26273 "FBA, FBX3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008562 26275 HIBCH http://www.ncbi.nlm.nih.gov/gene/?term=26275 HIBYLCOAH mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008563 26277 TINF2 http://www.ncbi.nlm.nih.gov/gene/?term=26277 "DKCA3, TIN2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008564 26277 TINF2 http://www.ncbi.nlm.nih.gov/gene/?term=26277 "DKCA3, TIN2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008565 26278 SACS http://www.ncbi.nlm.nih.gov/gene/?term=26278 "ARSACS, DNAJC29, PPP1R138, SPAX6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008566 26278 SACS http://www.ncbi.nlm.nih.gov/gene/?term=26278 "ARSACS, DNAJC29, PPP1R138, SPAX6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008567 2627 GATA6 http://www.ncbi.nlm.nih.gov/gene/?term=2627 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008568 2627 GATA6 http://www.ncbi.nlm.nih.gov/gene/?term=2627 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008569 26284 ERAL1 http://www.ncbi.nlm.nih.gov/gene/?term=26284 "CEGA, ERA, ERA-WA, H-ERA, HERA-A, HERA-B, ERAL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008570 2628 GATM http://www.ncbi.nlm.nih.gov/gene/?term=2628 "AGAT, AT, CCDS3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008571 26292 MYCBP http://www.ncbi.nlm.nih.gov/gene/?term=26292 AMY-1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008572 26292 MYCBP http://www.ncbi.nlm.nih.gov/gene/?term=26292 AMY-1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008573 26292 MYCBP http://www.ncbi.nlm.nih.gov/gene/?term=26292 AMY-1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008574 26298 EHF http://www.ncbi.nlm.nih.gov/gene/?term=26298 "ESE3, ESE3B, ESEJ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008575 2629 GBA http://www.ncbi.nlm.nih.gov/gene/?term=2629 "GBA1, GCB, GLUC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008576 2629 GBA http://www.ncbi.nlm.nih.gov/gene/?term=2629 "GBA1, GCB, GLUC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008577 262 AMD1 http://www.ncbi.nlm.nih.gov/gene/?term=262 "ADOMETDC, AMD, SAMDC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008578 262 AMD1 http://www.ncbi.nlm.nih.gov/gene/?term=262 "ADOMETDC, AMD, SAMDC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008579 26301 GBGT1 http://www.ncbi.nlm.nih.gov/gene/?term=26301 "A3GALNT, FS, UNQ2513 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008580 2631 GBAS http://www.ncbi.nlm.nih.gov/gene/?term=2631 NIPSNAP2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008581 2632 GBE1 http://www.ncbi.nlm.nih.gov/gene/?term=2632 "APBD, GBE, GSD4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008582 263406 Plekhg3 http://www.ncbi.nlm.nih.gov/gene/?term=263406 BC030417 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008583 26354 GNL3 http://www.ncbi.nlm.nih.gov/gene/?term=26354 "C77032, E2IG3, NNP47, NS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008584 26354 GNL3 http://www.ncbi.nlm.nih.gov/gene/?term=26354 "C77032, E2IG3, NNP47, NS " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008585 26355 FAM162A http://www.ncbi.nlm.nih.gov/gene/?term=26355 "C3orf28, E2IG5, HGTD-P " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008586 26356 Ing1 http://www.ncbi.nlm.nih.gov/gene/?term=26356 "2610028J21Rik, AA407184, AI875420, mING1h, p33Ing1, p37Ing1b " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008587 2635 GBP3 http://www.ncbi.nlm.nih.gov/gene/?term=2635 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008588 26374 Rfwd2 http://www.ncbi.nlm.nih.gov/gene/?term=26374 "AI316802, C80879, Cop1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008589 26374 Rfwd2 http://www.ncbi.nlm.nih.gov/gene/?term=26374 "AI316802, C80879, Cop1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008590 26385 Grk6 http://www.ncbi.nlm.nih.gov/gene/?term=26385 Gprk6 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008591 26388 Ifi202b http://www.ncbi.nlm.nih.gov/gene/?term=26388 "Ifbip-1, Ifi202, Ifi202a, p202 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008592 2639 GCDH http://www.ncbi.nlm.nih.gov/gene/?term=2639 "ACAD5, GCD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008593 26400 Map2k7 http://www.ncbi.nlm.nih.gov/gene/?term=26400 "5930412N11Rik, JNKK 2, Jnkk2, MAPKK 7, MEK 7, Mapkk7, Mek7, Mkk7, Prkmk7, sek2 " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00008594 264064 Cdk8 http://www.ncbi.nlm.nih.gov/gene/?term=264064 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008595 26407 Map3k4 http://www.ncbi.nlm.nih.gov/gene/?term=26407 "D17Rp17, D17Rp17e, MAPKKK4, MEKK 4, MTK1, Mek4b, Mekk4, RP17, Rp17a, Tas, mKIAA0213 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008596 26409 Map3k7 http://www.ncbi.nlm.nih.gov/gene/?term=26409 "B430101B05, C87327, Tak1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008597 26412 Map4k2 http://www.ncbi.nlm.nih.gov/gene/?term=26412 "AI385662, BL44, GCK, Rab8ip " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008598 26419 Mapk8 http://www.ncbi.nlm.nih.gov/gene/?term=26419 "AI849689, JNK, JNK1, Prkm8, SAPK1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008599 26420 Mapk9 http://www.ncbi.nlm.nih.gov/gene/?term=26420 "AI851083, JNK2, Prkm9, p54aSAPK " mRNA Mus musculus 21281539 Mitotic spindle Oocyte Beckman DU 530 Analyzer "The association of JNK2 with spindle poles was further confirmed by colocalization with the centrosomal proteins, r-tubulin and Plk1. " RLID00008600 26422 Nbea http://www.ncbi.nlm.nih.gov/gene/?term=26422 "Lyst2, mKIAA1544 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008601 26424 Nr5a2 http://www.ncbi.nlm.nih.gov/gene/?term=26424 "AU020803, D1Ertd308e, Ftf, LRH-1, UF2-H3B " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008602 26424 Nr5a2 http://www.ncbi.nlm.nih.gov/gene/?term=26424 "AU020803, D1Ertd308e, Ftf, LRH-1, UF2-H3B " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008603 26427 Creb3l1 http://www.ncbi.nlm.nih.gov/gene/?term=26427 Oasis mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008604 26428 Orc4 http://www.ncbi.nlm.nih.gov/gene/?term=26428 "Orc4Pl, mMmORC4, Orc4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008605 26429 Orc5 http://www.ncbi.nlm.nih.gov/gene/?term=26429 "AL033327, MmORC5l, Orc5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008606 2643 GCH1 http://www.ncbi.nlm.nih.gov/gene/?term=2643 "DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008607 26442 Psma5 http://www.ncbi.nlm.nih.gov/gene/?term=26442 ZETA mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008608 26446 Psmb3 http://www.ncbi.nlm.nih.gov/gene/?term=26446 "AL033320, C10-II " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008609 2644 GCHFR http://www.ncbi.nlm.nih.gov/gene/?term=2644 "GFRP, HsT16933, P35 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008610 2644 GCHFR http://www.ncbi.nlm.nih.gov/gene/?term=2644 "GFRP, HsT16933, P35 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008611 26451 Rpl27a http://www.ncbi.nlm.nih.gov/gene/?term=26451 "L27', L27A, L29 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008612 26466 Zfp260 http://www.ncbi.nlm.nih.gov/gene/?term=26466 "AI480997, Ozrf1, PEX1, Zfp63, Znf260 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008613 26469 PTPN18 http://www.ncbi.nlm.nih.gov/gene/?term=26469 "BDP1, PTP-HSCF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008614 26470 SEZ6L2 http://www.ncbi.nlm.nih.gov/gene/?term=26470 "BSRPA, PSK-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008615 26471 NUPR1 http://www.ncbi.nlm.nih.gov/gene/?term=26471 "COM1, P8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008616 26471 NUPR1 http://www.ncbi.nlm.nih.gov/gene/?term=26471 "COM1, P8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008617 26472 PPP1R14B http://www.ncbi.nlm.nih.gov/gene/?term=26472 "PHI-1, PLCB3N, PNG, SOM172 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008618 2647 BLOC1S1 http://www.ncbi.nlm.nih.gov/gene/?term=2647 "BLOS1, BORCS1, GCN5L1, MICoA, RT14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008619 2648 KAT2A http://www.ncbi.nlm.nih.gov/gene/?term=2648 "GCN5, GCN5L2, PCAF-b, hGCN5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008620 26499 PLEK2 http://www.ncbi.nlm.nih.gov/gene/?term=26499 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008621 2649 NR6A1 http://www.ncbi.nlm.nih.gov/gene/?term=2649 "CT150, GCNF, GCNF1, NR61, RTR, hGCNF, hRTR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008622 26502 NARF http://www.ncbi.nlm.nih.gov/gene/?term=26502 IOP2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008623 26502 NARF http://www.ncbi.nlm.nih.gov/gene/?term=26502 IOP2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008624 26503 SLC17A5 http://www.ncbi.nlm.nih.gov/gene/?term=26503 "AST, ISSD, NSD, SD, SIALIN, SIASD, SLD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008625 26505 CNNM3 http://www.ncbi.nlm.nih.gov/gene/?term=26505 ACDP3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008626 26505 CNNM3 http://www.ncbi.nlm.nih.gov/gene/?term=26505 ACDP3 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008627 26505 CNNM3 http://www.ncbi.nlm.nih.gov/gene/?term=26505 ACDP3 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008628 26509 MYOF http://www.ncbi.nlm.nih.gov/gene/?term=26509 FER1L3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008629 26511 CHIC2 http://www.ncbi.nlm.nih.gov/gene/?term=26511 BTL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008630 26512 INTS6 http://www.ncbi.nlm.nih.gov/gene/?term=26512 "DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008631 26515 TIMM10B http://www.ncbi.nlm.nih.gov/gene/?term=26515 "FXC1, TIM10B, Tim9b " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008632 26515 TIMM10B http://www.ncbi.nlm.nih.gov/gene/?term=26515 "FXC1, TIM10B, Tim9b " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008633 26515 TIMM10B http://www.ncbi.nlm.nih.gov/gene/?term=26515 "FXC1, TIM10B, Tim9b " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008634 26517 TIMM13 http://www.ncbi.nlm.nih.gov/gene/?term=26517 "TIM13, TIM13B, TIMM13A, TIMM13B, ppv1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008635 26517 TIMM13 http://www.ncbi.nlm.nih.gov/gene/?term=26517 "TIM13, TIM13BA, TIMM13B, ppv1, TIMM13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008636 26519 TIMM10 http://www.ncbi.nlm.nih.gov/gene/?term=26519 "TIM10, TIM10A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008637 26520 TIMM9 http://www.ncbi.nlm.nih.gov/gene/?term=26520 "TIM9, TIM9A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008638 26521 TIMM8B http://www.ncbi.nlm.nih.gov/gene/?term=26521 "DDP2, TIM8B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008639 26523 AGO1 http://www.ncbi.nlm.nih.gov/gene/?term=26523 "EIF2C, EIF2C1, GERP95, Q99, hAgo1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008640 26523 AGO1 http://www.ncbi.nlm.nih.gov/gene/?term=26523 "EIF2C, EIF2C1, GERP95, Q99, hAgo1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008641 26523 AGO1 http://www.ncbi.nlm.nih.gov/gene/?term=26523 "EIF2C, EIF2C1, GERP95, Q99, hAgo1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008642 2653 GCSH http://www.ncbi.nlm.nih.gov/gene/?term=2653 "GCE, NKH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008643 2653 GCSH http://www.ncbi.nlm.nih.gov/gene/?term=2653 "GCE, NKH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008644 26562 Ncdn http://www.ncbi.nlm.nih.gov/gene/?term=26562 "AU042419, MMS10-AE, Ms10ae, mKIAA0607, norbin " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008645 26572 Cops3 http://www.ncbi.nlm.nih.gov/gene/?term=26572 "Csn3, Sgn3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008646 26577 PCOLCE2 http://www.ncbi.nlm.nih.gov/gene/?term=26577 PCPE2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008647 26578 OSTF1 http://www.ncbi.nlm.nih.gov/gene/?term=26578 "OSF, SH3P2, bA235O14.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008648 26578 OSTF1 http://www.ncbi.nlm.nih.gov/gene/?term=26578 "OSF, SH3P2, bA235O14.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008649 26578 OSTF1 http://www.ncbi.nlm.nih.gov/gene/?term=26578 "OSF, SH3P2, bA235O14.1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008650 26579 MYEOV http://www.ncbi.nlm.nih.gov/gene/?term=26579 OCIM mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008651 26580 BSCL2 http://www.ncbi.nlm.nih.gov/gene/?term=26580 "GNG3LG, HMN5, PELD, SPG17 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008652 26586 CKAP2 http://www.ncbi.nlm.nih.gov/gene/?term=26586 "LB1, TMAP, se20-10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008653 26586 CKAP2 http://www.ncbi.nlm.nih.gov/gene/?term=26586 "LB1, TMAP, se20-10 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008654 26586 CKAP2 http://www.ncbi.nlm.nih.gov/gene/?term=26586 "LB1, TMAP, se20-10 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008655 26589 MRPL46 http://www.ncbi.nlm.nih.gov/gene/?term=26589 "C15orf4, LIECG2, P2ECSL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008656 26608 TBL2 http://www.ncbi.nlm.nih.gov/gene/?term=26608 "WBSCR13, WS-betaTRP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008657 26608 TBL2 http://www.ncbi.nlm.nih.gov/gene/?term=26608 "WBSCR13, WS-betaTRP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008658 26611 Rcn2 http://www.ncbi.nlm.nih.gov/gene/?term=26611 "AA408742, Tcbp49 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008659 26628 OR7E47P http://www.ncbi.nlm.nih.gov/gene/?term=26628 OR7E141 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008660 2662 GDF10 http://www.ncbi.nlm.nih.gov/gene/?term=2662 "BMP-3b, BMP3B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008661 2664 GDI1 http://www.ncbi.nlm.nih.gov/gene/?term=2664 "1A, GDIL, MRX41, MRX48, OPHN2, RABGD1A, RABGDIA, XAP-4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008662 2664 GDI1 http://www.ncbi.nlm.nih.gov/gene/?term=2664 "1A, GDIL, MRX41, MRX48, OPHN2, RABGD1A, RABGDIA, XAP-4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008663 2664 GDI1 http://www.ncbi.nlm.nih.gov/gene/?term=2664 "1A, GDIL, MRX41, MRX48, OPHN2, RABGD1A, RABGDIA, XAP-4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008664 2665 GDI2 http://www.ncbi.nlm.nih.gov/gene/?term=2665 "HEL-S-46e, RABGDIB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008665 2665 GDI2 http://www.ncbi.nlm.nih.gov/gene/?term=2665 "HEL-S-46e, RABGDIB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008666 2665 GDI2 http://www.ncbi.nlm.nih.gov/gene/?term=2665 "HEL-S-46e, RABGDIB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008667 266629 SEC14L3 http://www.ncbi.nlm.nih.gov/gene/?term=266629 TAP2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008668 266655 LINC00094 http://www.ncbi.nlm.nih.gov/gene/?term=266655 "LP2477, NCRNA00094, bA374P20.3 " lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008669 266740 MAGEA2B http://www.ncbi.nlm.nih.gov/gene/?term=266740 "CT1.2, MAGE2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008670 266759 Hspa4 http://www.ncbi.nlm.nih.gov/gene/?term=266759 "Hsp110, Hsp70, irp94 " mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00008671 266759 Hspa4 http://www.ncbi.nlm.nih.gov/gene/?term=266759 "Hsp110, Hsp70, irp94 " mRNA Rattus norvegicus 17439344 Cytoplasm Brain In situ hybridization "In contrast, mRNA of the cytoplasmic hsp70 was strongly induced at 4 h after brain injury in multiple brain regions within the injured hemisphere, and this expression was greatly en- hanced by secondary hypoxia. " RLID00008672 266759 Hspa4 http://www.ncbi.nlm.nih.gov/gene/?term=266759 "Hsp110, Hsp70, irp94 " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00008673 266781 Snx17 http://www.ncbi.nlm.nih.gov/gene/?term=266781 "5830447M19Rik, AI790646, D5Ertd260e, b2b1625.1Clo, mKIAA0064 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008674 266977 ADGRF1 http://www.ncbi.nlm.nih.gov/gene/?term=266977 "GPR110, KPG_012, PGR19, hGPCR36 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008675 267002 PGBD2 http://www.ncbi.nlm.nih.gov/gene/?term=267002 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008676 267010 RNU12 http://www.ncbi.nlm.nih.gov/gene/?term=267010 "RNU12-1L, RNU12P, dJ222E13.7, RNU12 " snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008677 267010 RNU12 http://www.ncbi.nlm.nih.gov/gene/?term=267010 "RNU12-1L, RNU12P, dJ222E13.7, RNU12 " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008678 267019 Rps15a http://www.ncbi.nlm.nih.gov/gene/?term=267019 A630031B11Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008679 267020 ATP5L2 http://www.ncbi.nlm.nih.gov/gene/?term=267020 ATP5K2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008680 2670 GFAP http://www.ncbi.nlm.nih.gov/gene/?term=2670 ALXDRD mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008681 2671 GFER http://www.ncbi.nlm.nih.gov/gene/?term=2671 "ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008682 2671 GFER http://www.ncbi.nlm.nih.gov/gene/?term=2671 "ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008683 2673 GFPT1 http://www.ncbi.nlm.nih.gov/gene/?term=2673 "CMS12, CMSTA1, GFA, GFAT, GFAT 1, GFAT1, GFAT1m, GFPTL, MSLG, GFPT1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008684 26762 HAVCR1 http://www.ncbi.nlm.nih.gov/gene/?term=26762 "CD365, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008685 26762 HAVCR1 http://www.ncbi.nlm.nih.gov/gene/?term=26762 "CD365, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008686 26765 SNORD12C http://www.ncbi.nlm.nih.gov/gene/?term=26765 "E2, E2-1, E3, RNU106, SNORD106, U106 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008687 26767 RNU105B http://www.ncbi.nlm.nih.gov/gene/?term=26767 "105B, E1-2 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008688 26767 RNU105B http://www.ncbi.nlm.nih.gov/gene/?term=26767 "105B, E1-2 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008689 26768 SNORA73B http://www.ncbi.nlm.nih.gov/gene/?term=26768 "105A, E1c, RNU105A, RNU17B, U17B " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008690 26768 SNORA73B http://www.ncbi.nlm.nih.gov/gene/?term=26768 "105A, E1c, RNU105A, RNU17B, U17B " snoRNA Homo sapiens 9671460 Nucleus HeLa cell Northern blot "We investigated the cellular localization of the U17HG RNA. Cell fractionation experiments indicated that U17HG RNA is enriched in the cytoplasm (Fig.5A), similar to UHG RNA, another noncoding snoRNA host having no protein-coding potential (Fig.5B). As expected, U17 snoRNA, used as a control, was found mainly in the nuclear fraction (Fig.5C). " RLID00008691 26768 SNORA73B http://www.ncbi.nlm.nih.gov/gene/?term=26768 "105A, E1c, RNU105A, RNU17B, U17B " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008692 26768 SNORA73B http://www.ncbi.nlm.nih.gov/gene/?term=26768 "105A, E1c, RNU105A, RNU17B, U17B " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008693 26768 SNORA73B http://www.ncbi.nlm.nih.gov/gene/?term=26768 "105A, E1c, RNU105A, RNU17B, U17B " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008694 26768 SNORA73B http://www.ncbi.nlm.nih.gov/gene/?term=26768 "105A, E1c, RNU105A, RNU17B, U17B " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008695 26769 SNORD81 http://www.ncbi.nlm.nih.gov/gene/?term=26769 "RNU104, U81, Z23 " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008696 26769 SNORD81 http://www.ncbi.nlm.nih.gov/gene/?term=26769 "RNU104, U81, Z23 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008697 26769 SNORD81 http://www.ncbi.nlm.nih.gov/gene/?term=26769 "RNU104, U81, Z23 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008698 26769 SNORD81 http://www.ncbi.nlm.nih.gov/gene/?term=26769 "RNU104, U81, Z23 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008699 2676 GFRA3 http://www.ncbi.nlm.nih.gov/gene/?term=2676 GDNFR3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008700 26770 SNORD79 http://www.ncbi.nlm.nih.gov/gene/?term=26770 "RNU103, U79, Z22 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008701 26771 SNORD102 http://www.ncbi.nlm.nih.gov/gene/?term=26771 "RNU102, Z18 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008702 26771 SNORD102 http://www.ncbi.nlm.nih.gov/gene/?term=26771 "RNU102, Z18 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008703 26773 SNORD4A http://www.ncbi.nlm.nih.gov/gene/?term=26773 "RNU101A, Z17A, mgh18S-121 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008704 26773 SNORD4A http://www.ncbi.nlm.nih.gov/gene/?term=26773 "RNU101A, Z17A, mgh18S-121 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008705 26773 SNORD4A http://www.ncbi.nlm.nih.gov/gene/?term=26773 "RNU101A, Z17A, mgh18S-121 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008706 26773 SNORD4A http://www.ncbi.nlm.nih.gov/gene/?term=26773 "RNU101A, Z17A, mgh18S-121 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008707 26774 SNORD80 http://www.ncbi.nlm.nih.gov/gene/?term=26774 "RNU100, U80, Z15 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00008708 26774 SNORD80 http://www.ncbi.nlm.nih.gov/gene/?term=26774 "RNU100, U80, Z15 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008709 26775 SNORA72 http://www.ncbi.nlm.nih.gov/gene/?term=26775 "RNU72, U72 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008710 26775 SNORA72 http://www.ncbi.nlm.nih.gov/gene/?term=26775 "RNU72, U72 " snoRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00008711 26776 SNORA71B http://www.ncbi.nlm.nih.gov/gene/?term=26776 "RNU71B, U71b " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008712 26776 SNORA71B http://www.ncbi.nlm.nih.gov/gene/?term=26776 "RNU71B, U71b " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008713 26776 SNORA71B http://www.ncbi.nlm.nih.gov/gene/?term=26776 "RNU71B, U71b " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008714 26777 SNORA71A http://www.ncbi.nlm.nih.gov/gene/?term=26777 "RNU71A, U71a " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008715 26778 SNORA70 http://www.ncbi.nlm.nih.gov/gene/?term=26778 "DXS648E, RNU70, U70 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008716 26779 SNORA69 http://www.ncbi.nlm.nih.gov/gene/?term=26779 "RNU69, U69, U69A " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008717 26779 SNORA69 http://www.ncbi.nlm.nih.gov/gene/?term=26779 "RNU69, U69, U69A " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008718 2677 GGCX http://www.ncbi.nlm.nih.gov/gene/?term=2677 VKCFD1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008719 2677 GGCX http://www.ncbi.nlm.nih.gov/gene/?term=2677 VKCFD1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008720 26782 SNORA66 http://www.ncbi.nlm.nih.gov/gene/?term=26782 "RNU66, U66 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008721 26783 SNORA65 http://www.ncbi.nlm.nih.gov/gene/?term=26783 "RNU65, U65 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008722 26784 SNORA64 http://www.ncbi.nlm.nih.gov/gene/?term=26784 "RNU64, U64 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00008723 26784 SNORA64 http://www.ncbi.nlm.nih.gov/gene/?term=26784 "RNU64, U64 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008724 26784 SNORA64 http://www.ncbi.nlm.nih.gov/gene/?term=26784 "RNU64, U64 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008725 26785 SNORD63 http://www.ncbi.nlm.nih.gov/gene/?term=26785 "RNU63A, U63, SNORD63 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008726 26785 SNORD63 http://www.ncbi.nlm.nih.gov/gene/?term=26785 "RNU63A, U63, SNORD63 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008727 26785 SNORD63 http://www.ncbi.nlm.nih.gov/gene/?term=26785 "RNU63A, U63, SNORD63 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008728 26786 SNORD62A http://www.ncbi.nlm.nih.gov/gene/?term=26786 "RNU62, U62, U62A " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008729 26786 SNORD62A http://www.ncbi.nlm.nih.gov/gene/?term=26786 "RNU62, U62, U62A " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008730 26786 SNORD62A http://www.ncbi.nlm.nih.gov/gene/?term=26786 "RNU62, U62, U62A " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008731 26786 SNORD62A http://www.ncbi.nlm.nih.gov/gene/?term=26786 "RNU62, U62, U62A " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008732 26788 SNORD60 http://www.ncbi.nlm.nih.gov/gene/?term=26788 "RNU60, U60 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00008733 26788 SNORD60 http://www.ncbi.nlm.nih.gov/gene/?term=26788 "RNU60, U60 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008734 26788 SNORD60 http://www.ncbi.nlm.nih.gov/gene/?term=26788 "RNU60, U60 " snoRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 6. Ten Most Highly Expressed snoRNAs of Exosome I, Exosome II and W. Data are collected from Table 6. " RLID00008735 26788 SNORD60 http://www.ncbi.nlm.nih.gov/gene/?term=26788 "RNU60, U60 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008736 26788 SNORD60 http://www.ncbi.nlm.nih.gov/gene/?term=26788 "RNU60, U60 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008737 26789 SNORD59A http://www.ncbi.nlm.nih.gov/gene/?term=26789 "RNU59, U59 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008738 26791 SNORD58A http://www.ncbi.nlm.nih.gov/gene/?term=26791 "RNU58A, U58a " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00008739 26791 SNORD58A http://www.ncbi.nlm.nih.gov/gene/?term=26791 "RNU58A, U58a " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008740 26792 SNORD57 http://www.ncbi.nlm.nih.gov/gene/?term=26792 "RNU57, U57 " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008741 26792 SNORD57 http://www.ncbi.nlm.nih.gov/gene/?term=26792 "RNU57, U57 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008742 26792 SNORD57 http://www.ncbi.nlm.nih.gov/gene/?term=26792 "RNU57, U57 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008743 26792 SNORD57 http://www.ncbi.nlm.nih.gov/gene/?term=26792 "RNU57, U57 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008744 26796 SNORD53 http://www.ncbi.nlm.nih.gov/gene/?term=26796 "RNU53A, U53, SNORD53 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008745 26798 SNORD51 http://www.ncbi.nlm.nih.gov/gene/?term=26798 "RNU51, U51 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008746 26799 SNORD50A http://www.ncbi.nlm.nih.gov/gene/?term=26799 "RNU50, U50 " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008747 26799 SNORD50A http://www.ncbi.nlm.nih.gov/gene/?term=26799 "RNU50, U50 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008748 267 AMFR http://www.ncbi.nlm.nih.gov/gene/?term=267 "GP78, RNF45 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008749 267 AMFR http://www.ncbi.nlm.nih.gov/gene/?term=267 "GP78, RNF45 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008750 26800 SNORD49A http://www.ncbi.nlm.nih.gov/gene/?term=26800 "RNU49, U49, U49A " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00008751 26800 SNORD49A http://www.ncbi.nlm.nih.gov/gene/?term=26800 "RNU49, U49, U49A " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008752 26800 SNORD49A http://www.ncbi.nlm.nih.gov/gene/?term=26800 "RNU49, U49, U49A " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008753 26801 SNORD48 http://www.ncbi.nlm.nih.gov/gene/?term=26801 "RNU48, U48 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00008754 26801 SNORD48 http://www.ncbi.nlm.nih.gov/gene/?term=26801 "RNU48, U48 " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008755 26802 SNORD47 http://www.ncbi.nlm.nih.gov/gene/?term=26802 "RNU47, U47 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00008756 26802 SNORD47 http://www.ncbi.nlm.nih.gov/gene/?term=26802 "RNU47, U47 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008757 26805 SNORD45A http://www.ncbi.nlm.nih.gov/gene/?term=26805 "RNU45A, U45a " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00008758 26805 SNORD45A http://www.ncbi.nlm.nih.gov/gene/?term=26805 "RNU45A, U45a " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008759 26805 SNORD45A http://www.ncbi.nlm.nih.gov/gene/?term=26805 "RNU45A, U45a " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008760 26806 SNORD44 http://www.ncbi.nlm.nih.gov/gene/?term=26806 "RNU44, U44 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00008761 26806 SNORD44 http://www.ncbi.nlm.nih.gov/gene/?term=26806 "RNU44, U44 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008762 26806 SNORD44 http://www.ncbi.nlm.nih.gov/gene/?term=26806 "RNU44, U44 " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008763 26806 SNORD44 http://www.ncbi.nlm.nih.gov/gene/?term=26806 "RNU44, U44 " snoRNA Homo sapiens 25203660 Cytoplasm HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008764 26806 SNORD44 http://www.ncbi.nlm.nih.gov/gene/?term=26806 "RNU44, U44 " snoRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 6. Ten Most Highly Expressed snoRNAs of Exosome I, Exosome II and W. Data are collected from Table 6. " RLID00008765 26806 SNORD44 http://www.ncbi.nlm.nih.gov/gene/?term=26806 "RNU44, U44 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008766 26806 SNORD44 http://www.ncbi.nlm.nih.gov/gene/?term=26806 "RNU44, U44 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008767 26807 SNORD43 http://www.ncbi.nlm.nih.gov/gene/?term=26807 "RNU43, U43 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008768 26807 SNORD43 http://www.ncbi.nlm.nih.gov/gene/?term=26807 "RNU43, U43 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008769 26808 SNORD42B http://www.ncbi.nlm.nih.gov/gene/?term=26808 "RNU42B, U42B " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008770 26809 SNORD42A http://www.ncbi.nlm.nih.gov/gene/?term=26809 "RNU42A, U42, U42A " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00008771 26810 SNORD41 http://www.ncbi.nlm.nih.gov/gene/?term=26810 "RNU41, U41 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008772 26811 SNORD55 http://www.ncbi.nlm.nih.gov/gene/?term=26811 "RNU39, RNU55, SNORD39, U39, U55 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00008773 26811 SNORD55 http://www.ncbi.nlm.nih.gov/gene/?term=26811 "RNU39, RNU55, SNORD39, U39, U55 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008774 26811 SNORD55 http://www.ncbi.nlm.nih.gov/gene/?term=26811 "RNU39, RNU55, SNORD39, U39, U55 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008775 26812 SNORD37 http://www.ncbi.nlm.nih.gov/gene/?term=26812 "RNU37, U37 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008776 26812 SNORD37 http://www.ncbi.nlm.nih.gov/gene/?term=26812 "RNU37, U37 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008777 26813 SNORD36C http://www.ncbi.nlm.nih.gov/gene/?term=26813 "RNU36C, U36c " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008778 26814 SNORD36B http://www.ncbi.nlm.nih.gov/gene/?term=26814 "RNU36B, U36b " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008779 26817 SNORD34 http://www.ncbi.nlm.nih.gov/gene/?term=26817 "RNU34, U34 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00008780 26817 SNORD34 http://www.ncbi.nlm.nih.gov/gene/?term=26817 "RNU34, U34 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008781 26818 SNORD33 http://www.ncbi.nlm.nih.gov/gene/?term=26818 "RNU33, U33 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00008782 26818 SNORD33 http://www.ncbi.nlm.nih.gov/gene/?term=26818 "RNU33, U33 " snoRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008783 26820 SNORD24 http://www.ncbi.nlm.nih.gov/gene/?term=26820 "RNU24, U24 " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008784 26820 SNORD24 http://www.ncbi.nlm.nih.gov/gene/?term=26820 "RNU24, U24 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00008785 26820 SNORD24 http://www.ncbi.nlm.nih.gov/gene/?term=26820 "RNU24, U24 " snoRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 6. Ten Most Highly Expressed snoRNAs of Exosome I, Exosome II and W. Data are collected from Table 6. " RLID00008786 26820 SNORD24 http://www.ncbi.nlm.nih.gov/gene/?term=26820 "RNU24, U24 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008787 26820 SNORD24 http://www.ncbi.nlm.nih.gov/gene/?term=26820 "RNU24, U24 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008788 26821 SNORA74A http://www.ncbi.nlm.nih.gov/gene/?term=26821 "RNU19, U19 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008789 26821 SNORA74A http://www.ncbi.nlm.nih.gov/gene/?term=26821 "RNU19, U19 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008790 26821 SNORA74A http://www.ncbi.nlm.nih.gov/gene/?term=26821 "RNU19, U19 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008791 26822 SNORD14A http://www.ncbi.nlm.nih.gov/gene/?term=26822 "RNU14, RNU14A, U14, U14-S13-5 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008792 26822 SNORD14A http://www.ncbi.nlm.nih.gov/gene/?term=26822 "RNU14, RNU14A, U14, U14-S13-5 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008793 26822 SNORD14A http://www.ncbi.nlm.nih.gov/gene/?term=26822 "RNU14, RNU14A, U14, U14-S13-5 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008794 26823 RNU12-2P http://www.ncbi.nlm.nih.gov/gene/?term=26823 "RNU12, RNU12P, U12 " snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008795 26824 RNU11 http://www.ncbi.nlm.nih.gov/gene/?term=26824 "RNU11-1, U11 " snRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00008796 26824 RNU11 http://www.ncbi.nlm.nih.gov/gene/?term=26824 "RNU11-1, U11 " snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008797 26824 RNU11 http://www.ncbi.nlm.nih.gov/gene/?term=26824 "RNU11-1, U11 " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008798 26824 RNU11 http://www.ncbi.nlm.nih.gov/gene/?term=26824 "RNU11-1, U11 " snRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008799 26826 RNU6-6P http://www.ncbi.nlm.nih.gov/gene/?term=26826 "RNU6-6, RNU6B, U6-6 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008800 26826 RNU6-6P http://www.ncbi.nlm.nih.gov/gene/?term=26826 "RNU6-6, RNU6B, U6-6 " snoRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00008801 26826 RNU6-6P http://www.ncbi.nlm.nih.gov/gene/?term=26826 "RNU6-6, RNU6B, U6-6 " snoRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00008802 26827 RNU6-1 http://www.ncbi.nlm.nih.gov/gene/?term=26827 "RNU6, RNU6A, U6, U6-1 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008803 26827 RNU6-1 http://www.ncbi.nlm.nih.gov/gene/?term=26827 "RNU6, RNU6A, U6, U6-1 " snRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008804 26827 RNU6-1 http://www.ncbi.nlm.nih.gov/gene/?term=26827 "RNU6, RNU6A, U6, U6-1 " snRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008805 268288 Samd3 http://www.ncbi.nlm.nih.gov/gene/?term=268288 Gm623 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008806 26828 RNU5F-1 http://www.ncbi.nlm.nih.gov/gene/?term=26828 "RNU5F, U5F " snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008807 26829 RNU5E-1 http://www.ncbi.nlm.nih.gov/gene/?term=26829 "RNU5E, U5E " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008808 26829 RNU5E-1 http://www.ncbi.nlm.nih.gov/gene/?term=26829 "RNU5E, U5E " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008809 26829 RNU5E-1 http://www.ncbi.nlm.nih.gov/gene/?term=26829 "RNU5E, U5E " snRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008810 26829 RNU5E-1 http://www.ncbi.nlm.nih.gov/gene/?term=26829 "RNU5E, U5E " snRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008811 268307 4833431D13Rik http://www.ncbi.nlm.nih.gov/gene/?term=268307 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008812 26830 RNU5D-1 http://www.ncbi.nlm.nih.gov/gene/?term=26830 "RNU5D, U5DL, U5DS " snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008813 26831 RNU5A-1 http://www.ncbi.nlm.nih.gov/gene/?term=26831 "RNU5, RNU5A, RNU5C, U5A, U5B1 " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008814 26831 RNU5A-1 http://www.ncbi.nlm.nih.gov/gene/?term=26831 "RNU5, RNU5A, RNU5C, U5A, U5B1 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008815 26831 RNU5A-1 http://www.ncbi.nlm.nih.gov/gene/?term=26831 "RNU5, RNU5A, RNU5C, U5A, U5B1 " snRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008816 26831 RNU5A-1 http://www.ncbi.nlm.nih.gov/gene/?term=26831 "RNU5, RNU5A, RNU5C, U5A, U5B1 " snRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008817 26832 RNU5B-1 http://www.ncbi.nlm.nih.gov/gene/?term=26832 "RNU5BP, U5B1, RNU5B-1 " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008818 26832 RNU5B-1 http://www.ncbi.nlm.nih.gov/gene/?term=26832 "RNU5BP, U5B1, RNU5B-1 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008819 26832 RNU5B-1 http://www.ncbi.nlm.nih.gov/gene/?term=26832 "RNU5BP, U5B1, RNU5B-1 " snRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008820 26832 RNU5B-1 http://www.ncbi.nlm.nih.gov/gene/?term=26832 "RNU5BP, U5B1, RNU5B-1 " snRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008821 26834 RNU4-2 http://www.ncbi.nlm.nih.gov/gene/?term=26834 "RNU4-1B, RNU4B1, RNU4C, U4A, U4b, U4c " snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008822 26834 RNU4-2 http://www.ncbi.nlm.nih.gov/gene/?term=26834 "RNU4-1B, RNU4B1, RNU4C, U4A, U4b, U4c " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008823 26835 RNU4-1 http://www.ncbi.nlm.nih.gov/gene/?term=26835 "RNU4A, RNU4B2, U4, U4BL " snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008824 26835 RNU4-1 http://www.ncbi.nlm.nih.gov/gene/?term=26835 "RNU4A, RNU4B2, U4, U4BL " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008825 26835 RNU4-1 http://www.ncbi.nlm.nih.gov/gene/?term=26835 "RNU4A, RNU4B2, U4, U4BL " snRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008826 26835 RNU4-1 http://www.ncbi.nlm.nih.gov/gene/?term=26835 "RNU4A, RNU4B2, U4, U4BL " snRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008827 268373 Ppia http://www.ncbi.nlm.nih.gov/gene/?term=268373 "2700098C05, Cphn, CyP-18, CypA " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008828 26838 RNU4-6P http://www.ncbi.nlm.nih.gov/gene/?term=26838 "RNU4P6, U4, U4/8 " snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008829 268390 Ahsa2 http://www.ncbi.nlm.nih.gov/gene/?term=268390 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008830 268395 Mpg http://www.ncbi.nlm.nih.gov/gene/?term=268395 "9830006D05, AI326268, APNG, Aag, Mid1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008831 2683 B4GALT1 http://www.ncbi.nlm.nih.gov/gene/?term=2683 "B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008832 2683 B4GALT1 http://www.ncbi.nlm.nih.gov/gene/?term=2683 "B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008833 268417 Zkscan17 http://www.ncbi.nlm.nih.gov/gene/?term=268417 "Nizp1, Zfp496, Znf496 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008834 268449 Rpl23a http://www.ncbi.nlm.nih.gov/gene/?term=268449 "BC029892, MDA20 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008835 268449 Rpl23a http://www.ncbi.nlm.nih.gov/gene/?term=268449 "BC029892, MDA20 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00008836 26844 RNU3P2 http://www.ncbi.nlm.nih.gov/gene/?term=26844 "U3, U3.2 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008837 26844 RNU3P2 http://www.ncbi.nlm.nih.gov/gene/?term=26844 "U3, U3.2 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008838 268482 Krt12 http://www.ncbi.nlm.nih.gov/gene/?term=268482 "AI835216, K12, Krt-12, Krt1-12 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008839 268512 Slc26a11 http://www.ncbi.nlm.nih.gov/gene/?term=268512 F630021I08Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008840 26851 SNORD3B-1 http://www.ncbi.nlm.nih.gov/gene/?term=26851 "RNU3A1, U3a, U3b1, U3b2 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008841 268527 Greb1 http://www.ncbi.nlm.nih.gov/gene/?term=268527 "5730583K22Rik, 9130004E13, AF180470, AU023194, mKIAA0575 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008842 26852 RNU2-5P http://www.ncbi.nlm.nih.gov/gene/?term=26852 RNU2P3 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008843 268534 Sntg2 http://www.ncbi.nlm.nih.gov/gene/?term=268534 "2210008K22Rik, 9530013L23, BB121248 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008844 26854 RNU2-3P http://www.ncbi.nlm.nih.gov/gene/?term=26854 "RNU2P1, U2 " snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008845 268566 Gphn http://www.ncbi.nlm.nih.gov/gene/?term=268566 "5730552E08Rik, AI662856, BC027112, C230040D23, GPH, GPHRYN, geph " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008846 26859 RNU1-14P http://www.ncbi.nlm.nih.gov/gene/?term=26859 "RNU1P7, U1P17 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008847 26860 RNU1-13P http://www.ncbi.nlm.nih.gov/gene/?term=26860 "RNU1-71, RNU1P6, RNVU1-2, U1.1, U1P1, vU1.2 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008848 26861 RNU1-11P http://www.ncbi.nlm.nih.gov/gene/?term=26861 "RNU1P1, RNU1P5, U1P1A " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008849 26863 RNVU1-18 http://www.ncbi.nlm.nih.gov/gene/?term=26863 "RNU1-25, RNU1-25P, RNU1-5, RNU1P1, RNU1P9, U1.15, U1P101, U1P15, vU1.18 " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008850 26863 RNVU1-18 http://www.ncbi.nlm.nih.gov/gene/?term=26863 "RNU1-25, RNU1-25P, RNU1-5, RNU1P1, RNU1P9, U1.15, U1P101, U1P15, vU1.18 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008851 26864 RNVU1-7 http://www.ncbi.nlm.nih.gov/gene/?term=26864 "RNU1-26P, RNU1-6, RNU1-6P, RNU1-9, RNU1-9P, RNVU1-9, vU1.7, vU1.9 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008852 26864 RNVU1-7 http://www.ncbi.nlm.nih.gov/gene/?term=26864 "RNU1-26P, RNU1-6, RNU1-6P, RNU1-9, RNU1-9P, RNVU1-9, vU1.7, vU1.9 " snRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00008853 268656 Sptlc1 http://www.ncbi.nlm.nih.gov/gene/?term=268656 "AW552086, C77762, E030036H05, Lcb1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008854 26865 RNU1-27P http://www.ncbi.nlm.nih.gov/gene/?term=26865 "RNU1-7, RNU1-7P " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008855 26865 RNU1-27P http://www.ncbi.nlm.nih.gov/gene/?term=26865 "RNU1-7, RNU1-7P " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008856 26866 RNU1-28P http://www.ncbi.nlm.nih.gov/gene/?term=26866 "RNU1-8, RNU1-8P " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008857 26866 RNU1-28P http://www.ncbi.nlm.nih.gov/gene/?term=26866 "RNU1-8, RNU1-8P " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008858 268697 Ccnb1 http://www.ncbi.nlm.nih.gov/gene/?term=268697 "Ccnb1-rs1-rs13, CycB1, Cycb-4, Cycb-5, Cycb1-rs1, Ccnb1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008859 268697 Ccnb1 http://www.ncbi.nlm.nih.gov/gene/?term=268697 "Ccnb1-rs1-rs13, CycB1, Cycb-4, Cycb-5, Cycb1-rs1, Ccnb1 " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00008860 26869 RNU1-3 http://www.ncbi.nlm.nih.gov/gene/?term=26869 "HSD4, RNU1G3 " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008861 26869 RNU1-3 http://www.ncbi.nlm.nih.gov/gene/?term=26869 "HSD4, RNU1G3 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008862 2686 GGT7 http://www.ncbi.nlm.nih.gov/gene/?term=2686 "D20S101, GGT4, GGTL3, GGTL5, dJ18C9.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008863 26870 RNU1-2 http://www.ncbi.nlm.nih.gov/gene/?term=26870 "RNU1C1, RNU1C2, U1C1, U1C21 " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008864 26870 RNU1-2 http://www.ncbi.nlm.nih.gov/gene/?term=26870 "RNU1C1, RNU1C2, U1C1, U1C21 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008865 26871 RNU1-1 http://www.ncbi.nlm.nih.gov/gene/?term=26871 "HSD1, HU1-1, RNU1, RNU1A, RNU1A3, RNU1G4, Rnu1a1, U1, U1A1 " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00008866 26871 RNU1-1 http://www.ncbi.nlm.nih.gov/gene/?term=26871 "HSD1, HU1-1, RNU1, RNU1A, RNU1A3, RNU1G4, Rnu1a1, U1, U1A1 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008867 26871 RNU1-1 http://www.ncbi.nlm.nih.gov/gene/?term=26871 "HSD1, HU1-1, RNU1, RNU1A, RNU1A3, RNU1G4, Rnu1a1, U1, U1A1 " snRNA Homo sapiens 1530887 Nucleus HeLa cell In situ hybridization "The localization of U1 and U2 small nuclear RNAs (snRNAs) has been examined by in situ hybridization using 2'-O-alkyl oligonucleotide probes. We have found that these snRNAs, which are essential for pre-mRNA splicing, localize in a speckled distribution, in addition to being present in three of four foci, in HeLa cell nuclei. However, in cells of defined passage, such as Detroit 551 and WI-38 fibroblasts, these snRNAs are concentrated in nuclear speckles, and foci are not observed. " RLID00008868 26871 RNU1-1 http://www.ncbi.nlm.nih.gov/gene/?term=26871 "HSD1, HU1-1, RNU1, RNU1A, RNU1A3, RNU1G4, Rnu1a1, U1, U1A1 " snRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008869 26871 RNU1-1 http://www.ncbi.nlm.nih.gov/gene/?term=26871 "HSD1, HU1-1, RNU1, RNU1A, RNU1A3, RNU1G4, Rnu1a1, U1, U1A1 " snRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008870 26872 STEAP1 http://www.ncbi.nlm.nih.gov/gene/?term=26872 "PRSS24, STEAP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008871 26872 STEAP1 http://www.ncbi.nlm.nih.gov/gene/?term=26872 "PRSS24, STEAP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008872 268749 Rnf31 http://www.ncbi.nlm.nih.gov/gene/?term=268749 "AL033293, BC031509, Flj10111, HOIP, Paul, mFLJ00217 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008873 26878 B3galt2 http://www.ncbi.nlm.nih.gov/gene/?term=26878 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008874 26879 B3galnt1 http://www.ncbi.nlm.nih.gov/gene/?term=26879 "B3galt3, b3GT3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008875 2687 GGT5 http://www.ncbi.nlm.nih.gov/gene/?term=2687 "GGL, GGT 5, GGT-REL, GGTLA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008876 268857 Nlrc3 http://www.ncbi.nlm.nih.gov/gene/?term=268857 "CLR16.2, D230007K08Rik, mFLJ00348 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008877 26893 Cops6 http://www.ncbi.nlm.nih.gov/gene/?term=26893 "Sgn3, VIP/MOV34 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008878 26894 Cops7a http://www.ncbi.nlm.nih.gov/gene/?term=26894 D6Ertd35e mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008879 268977 Ltbp1 http://www.ncbi.nlm.nih.gov/gene/?term=268977 "9430031G15Rik, 9830146M04, Ltbp-1, Tgfb, b2b1000Clo " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008880 268996 Ss18 http://www.ncbi.nlm.nih.gov/gene/?term=268996 "D130059H17, Ssxt, Syt " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008881 26900 Ddx3y http://www.ncbi.nlm.nih.gov/gene/?term=26900 "8030469F12Rik, D1Pas1-rs1, Dby " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008882 269033 4930503L19Rik http://www.ncbi.nlm.nih.gov/gene/?term=269033 "9930107F24, BB148262, Lars, Las2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008883 269053 Gpr152 http://www.ncbi.nlm.nih.gov/gene/?term=269053 "A930009H15Rik, Gm673 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008884 269061 Cpsf7 http://www.ncbi.nlm.nih.gov/gene/?term=269061 "5730453I16Rik, AL022757, C330017N18Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008885 26909 Exo1 http://www.ncbi.nlm.nih.gov/gene/?term=26909 "5730442G03Rik, Msa " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008886 2690 GHR http://www.ncbi.nlm.nih.gov/gene/?term=2690 "GHBP, GHIP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008887 2690 GHR http://www.ncbi.nlm.nih.gov/gene/?term=2690 "GHBP, GHIP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008888 26912 Gcat http://www.ncbi.nlm.nih.gov/gene/?term=26912 "AI526977, Kbl " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008889 26921 Map4k4 http://www.ncbi.nlm.nih.gov/gene/?term=26921 "9430080K19Rik, AU043147, AU045934, AW046177, HGK, Nik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008890 26922 Mecr http://www.ncbi.nlm.nih.gov/gene/?term=26922 "AI195831, Nrbf1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008891 269252 Gtf3c4 http://www.ncbi.nlm.nih.gov/gene/?term=269252 "5330400C03, AI426938, AU014771, AU017413, KAT12, TFIIIC90 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008892 269254 Setx http://www.ncbi.nlm.nih.gov/gene/?term=269254 "A130090N03, A930037J23Rik, AOA2, AW060766, Als4, SCAR1, Sen1, mKIAA0625 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008893 269261 Rpl12 http://www.ncbi.nlm.nih.gov/gene/?term=269261 E430018F03 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008894 269261 Rpl12 http://www.ncbi.nlm.nih.gov/gene/?term=269261 E430018F03 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008895 269261 Rpl12 http://www.ncbi.nlm.nih.gov/gene/?term=269261 E430018F03 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00008896 26926 Aifm1 http://www.ncbi.nlm.nih.gov/gene/?term=26926 "AIF, AIFsh2, Hq, Pdcd8 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008897 26932 Ppp2r5e http://www.ncbi.nlm.nih.gov/gene/?term=26932 "4633401M22Rik, AI449017, B56beta " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008898 269344 Ell3 http://www.ncbi.nlm.nih.gov/gene/?term=269344 A930015D22Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008899 26934 Racgap1 http://www.ncbi.nlm.nih.gov/gene/?term=26934 "AI227039, AI327394, Band25, GTPase, MgcRacGAP, gtl11, mKIAA1478 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008900 26936 Mprip http://www.ncbi.nlm.nih.gov/gene/?term=26936 "9530046C02, AA536749, AI647711, C76423, RIP3, Rhoip3, mKIAA0864, p116Rip " mRNA Mus musculus 18539120 Synapse Brain qRT-PCR "The mRNA targets reduced in Kif5 association included genes involved in actin remodeling at synapses (cofilin phosphatase (PP2Ac); p116-RIP), synapse-associated signaling (DAG1;RGS5) and synapse structure (SAPAP4; CaMKIIa; MAP1b). Not all mRNAs were significantly reduced in Kif5 IPs, as OCRL1 mRNA was similar in KO brain (P>0.05, n=8). " RLID00008901 269400 Rtel1 http://www.ncbi.nlm.nih.gov/gene/?term=269400 "AI451565, AW540478, Rtel " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008902 26940 Ecsit http://www.ncbi.nlm.nih.gov/gene/?term=26940 Sitpec mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008903 26941 Slc9a3r1 http://www.ncbi.nlm.nih.gov/gene/?term=26941 "EBP-50, NHE-RF, NHERF-1, NHERF1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008904 269424 Jade1 http://www.ncbi.nlm.nih.gov/gene/?term=269424 "AU041499, D530048A03Rik, Phf17, mKIAA1807 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008905 26942 Spag1 http://www.ncbi.nlm.nih.gov/gene/?term=26942 tpis mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008906 269470 Wdr3 http://www.ncbi.nlm.nih.gov/gene/?term=269470 "AW546279, D030020G18Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008907 269472 LOC269472 http://www.ncbi.nlm.nih.gov/gene/?term=269472 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008908 269473 Lrig2 http://www.ncbi.nlm.nih.gov/gene/?term=269473 "4632419I10Rik, BB096938, LIG-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008909 26949 Vat1 http://www.ncbi.nlm.nih.gov/gene/?term=26949 VAT-1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008910 26951 Zw10 http://www.ncbi.nlm.nih.gov/gene/?term=26951 "6330566F14Rik, MmZw10 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008911 269536 Tex10 http://www.ncbi.nlm.nih.gov/gene/?term=269536 "2610206N19Rik, 2810462N03Rik, BC006867 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008912 26953 RANBP6 http://www.ncbi.nlm.nih.gov/gene/?term=26953 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008913 26953 RANBP6 http://www.ncbi.nlm.nih.gov/gene/?term=26953 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008914 26953 RANBP6 http://www.ncbi.nlm.nih.gov/gene/?term=26953 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008915 269582 Clspn http://www.ncbi.nlm.nih.gov/gene/?term=269582 "B130025E01, C85083, E130314M08Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008916 26958 COPG2 http://www.ncbi.nlm.nih.gov/gene/?term=26958 "2-COP, gamma-2-COP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008917 269593 Luzp1 http://www.ncbi.nlm.nih.gov/gene/?term=269593 "2700072H04Rik, AI266952, Luzp, mFLJ00226 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008918 26959 HBP1 http://www.ncbi.nlm.nih.gov/gene/?term=26959 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008919 269614 Pank4 http://www.ncbi.nlm.nih.gov/gene/?term=269614 "D030031I12Rik, R75150 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008920 269623 Rbm48 http://www.ncbi.nlm.nih.gov/gene/?term=269623 "AW548102, C030048B08Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008921 26965 Cul1 http://www.ncbi.nlm.nih.gov/gene/?term=26965 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008922 269682 Golga3 http://www.ncbi.nlm.nih.gov/gene/?term=269682 "5330413L04, 5430416E01Rik, AI449376, AW490576, G1-499-14, Mea-2, Mea2, repro27 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008923 269704 Zfp664 http://www.ncbi.nlm.nih.gov/gene/?term=269704 "AW060232, D930038J03Rik, ZFOC1, Znf664 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008924 26970 Pla2g2e http://www.ncbi.nlm.nih.gov/gene/?term=26970 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008925 26973 CHORDC1 http://www.ncbi.nlm.nih.gov/gene/?term=26973 CHP1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008926 269784 Cntn4 http://www.ncbi.nlm.nih.gov/gene/?term=269784 "9630050B05, Axcam, BIG-2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008927 269788 Lhfpl4 http://www.ncbi.nlm.nih.gov/gene/?term=269788 "1190004M23Rik, AI604880, B230384L07, mKIAA4027 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008928 2697 GJA1 http://www.ncbi.nlm.nih.gov/gene/?term=2697 "AVSD3, CMDR, CX43, EKVP, GJAL, HLHS1, HSS, ODDD, PPKCA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008929 2697 GJA1 http://www.ncbi.nlm.nih.gov/gene/?term=2697 "AVSD3, CMDR, CX43, EKVP, GJAL, HLHS1, HSS, ODDD, PPKCA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008930 26984 SEC22A http://www.ncbi.nlm.nih.gov/gene/?term=26984 SEC22L2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008931 26985 AP3M1 http://www.ncbi.nlm.nih.gov/gene/?term=26985 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008932 26985 AP3M1 http://www.ncbi.nlm.nih.gov/gene/?term=26985 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008933 26985 AP3M1 http://www.ncbi.nlm.nih.gov/gene/?term=26985 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008934 26986 PABPC1 http://www.ncbi.nlm.nih.gov/gene/?term=26986 "PAB1, PABP, PABP1, PABPC2, PABPL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008935 26986 PABPC1 http://www.ncbi.nlm.nih.gov/gene/?term=26986 "PAB1, PABP, PABP1, PABPC2, PABPL1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008936 26986 PABPC1 http://www.ncbi.nlm.nih.gov/gene/?term=26986 "PAB1, PABP, PABP1, PABPC2, PABPL1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008937 26986 PABPC1 http://www.ncbi.nlm.nih.gov/gene/?term=26986 "PAB1, PABP, PABP1, PABPC2, PABPL1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008938 26986 PABPC1 http://www.ncbi.nlm.nih.gov/gene/?term=26986 "PAB1, PABP, PABP1, PABPC2, PABPL1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008939 269881 Map3k10 http://www.ncbi.nlm.nih.gov/gene/?term=269881 "BC028668, BC046514, MST, Mlk2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008940 269941 Chsy1 http://www.ncbi.nlm.nih.gov/gene/?term=269941 mKIAA0990 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008941 26994 RNF11 http://www.ncbi.nlm.nih.gov/gene/?term=26994 "CGI-123, SID1669 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008942 269955 Rccd1 http://www.ncbi.nlm.nih.gov/gene/?term=269955 "5830436H09, E430018M08Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008943 26995 TRUB2 http://www.ncbi.nlm.nih.gov/gene/?term=26995 CLONE24922 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008944 26996 GPR160 http://www.ncbi.nlm.nih.gov/gene/?term=26996 "GPCR1, GPCR150 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008945 26996 GPR160 http://www.ncbi.nlm.nih.gov/gene/?term=26996 "GPCR1, GPCR150 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008946 26999 CYFIP2 http://www.ncbi.nlm.nih.gov/gene/?term=26999 PIR121 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008947 26999 CYFIP2 http://www.ncbi.nlm.nih.gov/gene/?term=26999 PIR121 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008948 26999 CYFIP2 http://www.ncbi.nlm.nih.gov/gene/?term=26999 PIR121 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008949 27000 DNAJC2 http://www.ncbi.nlm.nih.gov/gene/?term=27000 "MPHOSPH11, MPP11, ZRF1, ZUO1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008950 27000 DNAJC2 http://www.ncbi.nlm.nih.gov/gene/?term=27000 "MPHOSPH11, MPP11, ZRF1, ZUO1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008951 27000 DNAJC2 http://www.ncbi.nlm.nih.gov/gene/?term=27000 "MPHOSPH11, MPP11, ZRF1, ZUO1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008952 270028 Fam155a http://www.ncbi.nlm.nih.gov/gene/?term=270028 "6430500D16, AW121567, Tmem28 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008953 270049 Galntl6 http://www.ncbi.nlm.nih.gov/gene/?term=270049 "1700021K10Rik, 4930431L04Rik, A830023L05 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008954 27004 TCL6 http://www.ncbi.nlm.nih.gov/gene/?term=27004 "TNG1, TNG2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008955 27004 TCL6 http://www.ncbi.nlm.nih.gov/gene/?term=27004 "TNG1, TNG2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008956 270058 Map1s http://www.ncbi.nlm.nih.gov/gene/?term=270058 "6430517J16Rik, Bpy2ip1, Map8, Mtap1s, VCY2IP1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008957 27005 USP21 http://www.ncbi.nlm.nih.gov/gene/?term=27005 "USP16, USP23 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008958 270097 Vat1l http://www.ncbi.nlm.nih.gov/gene/?term=270097 "9430073I07, AI427515, mKIAA1576 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008959 270106 Rpl13 http://www.ncbi.nlm.nih.gov/gene/?term=270106 "A52, L13 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008960 270106 Rpl13 http://www.ncbi.nlm.nih.gov/gene/?term=270106 "A52, L13 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00008961 27010 TPK1 http://www.ncbi.nlm.nih.gov/gene/?term=27010 "HTPK1, PP20, THMD5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008962 27013 CNPPD1 http://www.ncbi.nlm.nih.gov/gene/?term=27013 "C2orf24, CGI-57 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008963 27018 BEX3 http://www.ncbi.nlm.nih.gov/gene/?term=27018 "Bex, DXS6984E, HGR74, NADE, NGFRAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008964 27018 BEX3 http://www.ncbi.nlm.nih.gov/gene/?term=27018 "Bex, DXS6984E, HGR74, NADE, NGFRAP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008965 270190 Ephb1 http://www.ncbi.nlm.nih.gov/gene/?term=270190 "9330129L11, AW488255, C130099E04Rik, Cek6, ENSMUSG00000074119, Elk, Elkh, Hek6, Net " mRNA Mus musculus 18524895 Axon Embryo RT-PCR "Interestingly, EphB1 mRNA is also localized to the distal axonal compartment (Fig. 3B, lane 6). This result indicates that Zic2 activates transcription of EphB1 mRNA in the cell nucleus and that EphB1 mRNA is transported down to the axon terminus. " RLID00008966 27020 NPTN http://www.ncbi.nlm.nih.gov/gene/?term=27020 "GP55, GP65, SDFR1, SDR1, np55, np65 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008967 27030 MLH3 http://www.ncbi.nlm.nih.gov/gene/?term=27030 HNPCC7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008968 27030 MLH3 http://www.ncbi.nlm.nih.gov/gene/?term=27030 HNPCC7 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008969 27032 ATP2C1 http://www.ncbi.nlm.nih.gov/gene/?term=27032 "ATP2C1A, BCPM, HHD, PMR1, SPCA1, hSPCA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008970 27034 ACAD8 http://www.ncbi.nlm.nih.gov/gene/?term=27034 "ACAD-8, ARC42 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008971 27034 ACAD8 http://www.ncbi.nlm.nih.gov/gene/?term=27034 "ACAD-8, ARC42 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008972 27037 TRMT2A http://www.ncbi.nlm.nih.gov/gene/?term=27037 HTF9C mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008973 27037 TRMT2A http://www.ncbi.nlm.nih.gov/gene/?term=27037 HTF9C mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008974 27040 LAT http://www.ncbi.nlm.nih.gov/gene/?term=27040 "LAT1, pp36 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008975 27042 DIEXF http://www.ncbi.nlm.nih.gov/gene/?term=27042 "C1orf107, DEF, DJ434O14.5, UTP25 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008976 27042 DIEXF http://www.ncbi.nlm.nih.gov/gene/?term=27042 "C1orf107, DEF, DJ434O14.5, UTP25 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008977 27042 DIEXF http://www.ncbi.nlm.nih.gov/gene/?term=27042 "C1orf107, DEF, DJ434O14.5, UTP25 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00008978 27043 PELP1 http://www.ncbi.nlm.nih.gov/gene/?term=27043 "MNAR, P160 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008979 27044 SND1 http://www.ncbi.nlm.nih.gov/gene/?term=27044 "TDRD11, p100 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008980 27044 SND1 http://www.ncbi.nlm.nih.gov/gene/?term=27044 "TDRD11, p100 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008981 27044 SND1 http://www.ncbi.nlm.nih.gov/gene/?term=27044 "TDRD11, p100 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008982 27045 Nit1 http://www.ncbi.nlm.nih.gov/gene/?term=27045 "AI255805, ESTM30, W57327 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008983 27052 Aoah http://www.ncbi.nlm.nih.gov/gene/?term=27052 4930433E13Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008984 27053 Asns http://www.ncbi.nlm.nih.gov/gene/?term=27053 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008985 27055 Fkbp9 http://www.ncbi.nlm.nih.gov/gene/?term=27055 "1810014L23, AW549641, FKBP-63, FKBP-9, FKBP60, FKBP63, FKBP65RS " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008986 2705 GJB1 http://www.ncbi.nlm.nih.gov/gene/?term=2705 "CMTX, CMTX1, CX32 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008987 27061 Bcap31 http://www.ncbi.nlm.nih.gov/gene/?term=27061 Bap31 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008988 270627 Taf1 http://www.ncbi.nlm.nih.gov/gene/?term=270627 "AU015687, B430306D02Rik, Ccg-1, Ccg1, KAT4, N-TAF1, TAFII250, Taf2a, p250 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008989 27062 Cadps http://www.ncbi.nlm.nih.gov/gene/?term=27062 "AU067781, CAPS, CAPS1, mKIAA1121 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00008990 27067 STAU2 http://www.ncbi.nlm.nih.gov/gene/?term=27067 "39K2, 39K3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008991 270685 Mthfd1l http://www.ncbi.nlm.nih.gov/gene/?term=270685 "2410004L15Rik, AI647056, Fthfsdc1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00008992 27068 PPA2 http://www.ncbi.nlm.nih.gov/gene/?term=27068 "HSPC124, SID6-306 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008993 27068 PPA2 http://www.ncbi.nlm.nih.gov/gene/?term=27068 "HSPC124, SID6-306 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008994 27068 PPA2 http://www.ncbi.nlm.nih.gov/gene/?term=27068 "HSPC124, SID6-306 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00008995 27069 GHITM http://www.ncbi.nlm.nih.gov/gene/?term=27069 "DERP2, HSPC282, MICS1, My021, PTD010, TMBIM5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008996 2706 GJB2 http://www.ncbi.nlm.nih.gov/gene/?term=2706 "CX26, DFNA3, DFNA3A, DFNB1, DFNB1A, HID, KID, NSRD1, PPK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008997 2706 GJB2 http://www.ncbi.nlm.nih.gov/gene/?term=2706 "CX26, DFNA3, DFNA3A, DFNB1, DFNB1A, HID, KID, NSRD1, PPK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00008998 27072 VPS41 http://www.ncbi.nlm.nih.gov/gene/?term=27072 "HVPS41, HVSP41, hVps41p " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00008999 27072 VPS41 http://www.ncbi.nlm.nih.gov/gene/?term=27072 "HVPS41, HVSP41, hVps41p " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009000 27075 TSPAN13 http://www.ncbi.nlm.nih.gov/gene/?term=27075 "NET-6, NET6, TM4SF13 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009001 27077 B9D1 http://www.ncbi.nlm.nih.gov/gene/?term=27077 "B9, EPPB9, MKS9, MKSR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009002 27077 B9D1 http://www.ncbi.nlm.nih.gov/gene/?term=27077 "B9, EPPB9, MKS9, MKSR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009003 27078 B9d1 http://www.ncbi.nlm.nih.gov/gene/?term=27078 "AW045994, B9, Eppb9 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009004 27079 RPUSD2 http://www.ncbi.nlm.nih.gov/gene/?term=27079 "C15orf19, C18B11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009005 2707 GJB3 http://www.ncbi.nlm.nih.gov/gene/?term=2707 "CX31, DFNA2, DFNA2B, EKV " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009006 27086 FOXP1 http://www.ncbi.nlm.nih.gov/gene/?term=27086 "12CC4, HSPC215, MFH, QRF1, hFKH1B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009007 27089 UQCRQ http://www.ncbi.nlm.nih.gov/gene/?term=27089 "MC3DN4, QCR8, QP-C, QPC, UQCR7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009008 27089 UQCRQ http://www.ncbi.nlm.nih.gov/gene/?term=27089 "MC3DN4, QCR8, QP-C, QPC, UQCR7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009009 27089 UQCRQ http://www.ncbi.nlm.nih.gov/gene/?term=27089 "MC3DN4, QCR8, QP-C, QPC, UQCR7 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009010 27089 UQCRQ http://www.ncbi.nlm.nih.gov/gene/?term=27089 "MC3DN4, QCR8, QP-C, QPC, UQCR7 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009011 27090 ST6GALNAC4 http://www.ncbi.nlm.nih.gov/gene/?term=27090 "IV, SIAT3-C, SIAT3C, SIAT7-D, SIAT7D, ST6GALNACIV, ST6GalNAc " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009012 27092 CACNG4 http://www.ncbi.nlm.nih.gov/gene/?term=27092 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009013 27095 TRAPPC3 http://www.ncbi.nlm.nih.gov/gene/?term=27095 BET3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009014 27095 TRAPPC3 http://www.ncbi.nlm.nih.gov/gene/?term=27095 BET3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009015 2709 GJB5 http://www.ncbi.nlm.nih.gov/gene/?term=2709 CX31.1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009016 27101 CACYBP http://www.ncbi.nlm.nih.gov/gene/?term=27101 "GIG5, PNAS-107, S100A6BP, SIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009017 27101 CACYBP http://www.ncbi.nlm.nih.gov/gene/?term=27101 "GIG5, PNAS-107, S100A6BP, SIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009018 27101 CACYBP http://www.ncbi.nlm.nih.gov/gene/?term=27101 "GIG5, PNAS-107, S100A6BP, SIP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009019 27102 EIF2AK1 http://www.ncbi.nlm.nih.gov/gene/?term=27102 "HCR, HRI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009020 27102 EIF2AK1 http://www.ncbi.nlm.nih.gov/gene/?term=27102 "HCR, HRI " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009021 271036 Catsperb http://www.ncbi.nlm.nih.gov/gene/?term=271036 "4931410B03, 4932415G16Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009022 27103 Eif2ak4 http://www.ncbi.nlm.nih.gov/gene/?term=27103 "2610011M03, GCN2, MGCN2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009023 27107 ZBTB11 http://www.ncbi.nlm.nih.gov/gene/?term=27107 "ZNF-U69274, ZNF913 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009024 27109 ATP5S http://www.ncbi.nlm.nih.gov/gene/?term=27109 "ATPW, FB, HSU79253 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009025 27113 BBC3 http://www.ncbi.nlm.nih.gov/gene/?term=27113 "JFY-1, JFY1, PUMA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009026 27113 BBC3 http://www.ncbi.nlm.nih.gov/gene/?term=27113 "JFY-1, JFY1, PUMA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009027 27124 INPP5J http://www.ncbi.nlm.nih.gov/gene/?term=27124 "INPP5, PIB5PA, PIPP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009028 27125 AFF4 http://www.ncbi.nlm.nih.gov/gene/?term=27125 "AF5Q31, CHOPS, MCEF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009029 27125 AFF4 http://www.ncbi.nlm.nih.gov/gene/?term=27125 "AF5Q31, CHOPS, MCEF " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009030 27131 SNX5 http://www.ncbi.nlm.nih.gov/gene/?term=27131 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009031 27134 TJP3 http://www.ncbi.nlm.nih.gov/gene/?term=27134 "ZO-3, ZO3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009032 271377 Zbtb11 http://www.ncbi.nlm.nih.gov/gene/?term=271377 "9230110G02Rik, ZNF-U69274 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009033 27141 CIDEB http://www.ncbi.nlm.nih.gov/gene/?term=27141 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009034 27141 CIDEB http://www.ncbi.nlm.nih.gov/gene/?term=27141 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009035 27143 PALD1 http://www.ncbi.nlm.nih.gov/gene/?term=27143 "KIAA1274, PALD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009036 271564 Vps13a http://www.ncbi.nlm.nih.gov/gene/?term=271564 "4930425F11, 4930516E05Rik, 4930543C13Rik, 9930023P20, Chac, Chorein, D330038K10Rik, mKIAA0986 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009037 27161 AGO2 http://www.ncbi.nlm.nih.gov/gene/?term=27161 "EIF2C2, Q10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009038 27161 AGO2 http://www.ncbi.nlm.nih.gov/gene/?term=27161 "EIF2C2, Q10 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009039 27163 NAAA http://www.ncbi.nlm.nih.gov/gene/?term=27163 "ASAHL, PLT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009040 27163 NAAA http://www.ncbi.nlm.nih.gov/gene/?term=27163 "ASAHL, PLT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009041 27166 PRELID1 http://www.ncbi.nlm.nih.gov/gene/?term=27166 "CGI-106, PRELI, PX19, SBBI12 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009042 27166 PRELID1 http://www.ncbi.nlm.nih.gov/gene/?term=27166 "CGI-106, PRELI, PX19, SBBI12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009043 27173 SLC39A1 http://www.ncbi.nlm.nih.gov/gene/?term=27173 "ZIP1, ZIRTL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009044 27173 SLC39A1 http://www.ncbi.nlm.nih.gov/gene/?term=27173 "ZIP1, ZIRTL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009045 27175 TUBG2 http://www.ncbi.nlm.nih.gov/gene/?term=27175 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009046 27175 TUBG2 http://www.ncbi.nlm.nih.gov/gene/?term=27175 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009047 27176 Rpl7a http://www.ncbi.nlm.nih.gov/gene/?term=27176 Surf3 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00009048 27176 Rpl7a http://www.ncbi.nlm.nih.gov/gene/?term=27176 Surf3 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00009049 2717 GLA http://www.ncbi.nlm.nih.gov/gene/?term=2717 GALA mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009050 2717 GLA http://www.ncbi.nlm.nih.gov/gene/?term=2717 GALA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009051 2717 GLA http://www.ncbi.nlm.nih.gov/gene/?term=2717 GALA mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009052 27181 SIGLEC8 http://www.ncbi.nlm.nih.gov/gene/?term=27181 "SAF2, SIGLEC-8L, SIGLEC8 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009053 27181 SIGLEC8 http://www.ncbi.nlm.nih.gov/gene/?term=27181 "SAF2, SIGLEC-8L, SIGLEC8 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009054 27183 VPS4A http://www.ncbi.nlm.nih.gov/gene/?term=27183 "SKD1, SKD1A, SKD2, VPS4, VPS4-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009055 27183 VPS4A http://www.ncbi.nlm.nih.gov/gene/?term=27183 "SKD1, SKD1A, SKD2, VPS4, VPS4-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009056 27183 VPS4A http://www.ncbi.nlm.nih.gov/gene/?term=27183 "SKD1, SKD1A, SKD2, VPS4, VPS4-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009057 27185 DISC1 http://www.ncbi.nlm.nih.gov/gene/?term=27185 "C1orf136, SCZD9 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009058 27185 DISC1 http://www.ncbi.nlm.nih.gov/gene/?term=27185 "C1orf136, SCZD9 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009059 271981 Tbck http://www.ncbi.nlm.nih.gov/gene/?term=271981 "1700120J03Rik, 9430001M19, A630047E20Rik, C030007I09Rikl, Tbck " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009060 27198 HCAR1 http://www.ncbi.nlm.nih.gov/gene/?term=27198 "FKSG80, GPR104, GPR81, HCA1, LACR1, TA-GPCR, TAGPCR " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009061 27198 HCAR1 http://www.ncbi.nlm.nih.gov/gene/?term=27198 "FKSG80, GPR104, GPR81, HCA1, LACR1, TA-GPCR, TAGPCR " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009062 2719 GPC3 http://www.ncbi.nlm.nih.gov/gene/?term=2719 "DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009063 271 AMPD2 http://www.ncbi.nlm.nih.gov/gene/?term=271 "PCH9, SPG63 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009064 27207 Rps11 http://www.ncbi.nlm.nih.gov/gene/?term=27207 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00009065 27209 Snord32a http://www.ncbi.nlm.nih.gov/gene/?term=27209 "Rnu32, Rnu32a, U32, U32A " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00009066 2720 GLB1 http://www.ncbi.nlm.nih.gov/gene/?term=2720 "EBP, ELNR1, MPS4B " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009067 2720 GLB1 http://www.ncbi.nlm.nih.gov/gene/?term=2720 "EBP, ELNR1, MPS4B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009068 2720 GLB1 http://www.ncbi.nlm.nih.gov/gene/?term=2720 "EBP, ELNR1, MPS4B " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009069 27214 Dbf4 http://www.ncbi.nlm.nih.gov/gene/?term=27214 "AA545217, Ask " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009070 272158 Poln http://www.ncbi.nlm.nih.gov/gene/?term=272158 POL4P mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009071 27218 Slamf1 http://www.ncbi.nlm.nih.gov/gene/?term=27218 "4933415F16, AA177906, CD150, CDw150, ESTM51, IPO-3, Slam " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009072 27220 Cartpt http://www.ncbi.nlm.nih.gov/gene/?term=27220 Cart mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009073 27223 Trp53bp1 http://www.ncbi.nlm.nih.gov/gene/?term=27223 "53BP1, Tp53bp1, m53BP1, p53BP1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009074 27229 TUBGCP4 http://www.ncbi.nlm.nih.gov/gene/?term=27229 "76P, GCP-4, GCP4, Grip76, MCCRP3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009075 27230 SERP1 http://www.ncbi.nlm.nih.gov/gene/?term=27230 RAMP4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009076 27230 SERP1 http://www.ncbi.nlm.nih.gov/gene/?term=27230 RAMP4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009077 27230 SERP1 http://www.ncbi.nlm.nih.gov/gene/?term=27230 RAMP4 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009078 27235 COQ2 http://www.ncbi.nlm.nih.gov/gene/?term=27235 "CL640, COQ10D1, MSA1, PHB:PPT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009079 27236 ARFIP1 http://www.ncbi.nlm.nih.gov/gene/?term=27236 HSU52521 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009080 27237 ARHGEF16 http://www.ncbi.nlm.nih.gov/gene/?term=27237 "GEF16, NBR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009081 27238 GPKOW http://www.ncbi.nlm.nih.gov/gene/?term=27238 "GPATC5, GPATCH5, Spp2, T54 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009082 27239 GPR162 http://www.ncbi.nlm.nih.gov/gene/?term=27239 "A-2, GRCA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009083 27242 TNFRSF21 http://www.ncbi.nlm.nih.gov/gene/?term=27242 "BM-018, CD358, DR6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009084 27243 CHMP2A http://www.ncbi.nlm.nih.gov/gene/?term=27243 "BC-2, BC2, CHMP2, VPS2, VPS2A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009085 27243 CHMP2A http://www.ncbi.nlm.nih.gov/gene/?term=27243 "BC-2, BC2, CHMP2, VPS2, VPS2A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009086 27244 SESN1 http://www.ncbi.nlm.nih.gov/gene/?term=27244 "PA26, SEST1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009087 27244 SESN1 http://www.ncbi.nlm.nih.gov/gene/?term=27244 "PA26, SEST1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009088 27245 AHDC1 http://www.ncbi.nlm.nih.gov/gene/?term=27245 MRD25 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009089 27247 NFU1 http://www.ncbi.nlm.nih.gov/gene/?term=27247 "CGI-33, HIRIP, HIRIP5, MMDS1, NIFUC, Nfu, NifU " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009090 27248 ERLEC1 http://www.ncbi.nlm.nih.gov/gene/?term=27248 "C2orf30, CIM, CL24936, CL25084, HEL117, XTP3-B, XTP3TPB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009091 27249 MMADHC http://www.ncbi.nlm.nih.gov/gene/?term=27249 "C2orf25, CL25022, cblD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009092 27250 PDCD4 http://www.ncbi.nlm.nih.gov/gene/?term=27250 H731 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009093 27250 PDCD4 http://www.ncbi.nlm.nih.gov/gene/?term=27250 H731 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009094 27252 KLHL20 http://www.ncbi.nlm.nih.gov/gene/?term=27252 "KHLHX, KLEIP, KLHLX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009095 27254 CSDC2 http://www.ncbi.nlm.nih.gov/gene/?term=27254 "PIPPIN, dJ347H13.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009096 272551 Gins2 http://www.ncbi.nlm.nih.gov/gene/?term=272551 "2210013I18Rik, 4833427B12Rik, AI323585, Pfs2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009097 27257 LSM1 http://www.ncbi.nlm.nih.gov/gene/?term=27257 "CASM, YJL124C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009098 27257 LSM1 http://www.ncbi.nlm.nih.gov/gene/?term=27257 "CASM, YJL124C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009099 27257 LSM1 http://www.ncbi.nlm.nih.gov/gene/?term=27257 "CASM, YJL124C " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009100 272589 Tbcel http://www.ncbi.nlm.nih.gov/gene/?term=272589 "D330014K23, E130107N23Rik, Lrrc35 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00009101 27258 LSM3 http://www.ncbi.nlm.nih.gov/gene/?term=27258 "SMX4, USS2, YLR438C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009102 27258 LSM3 http://www.ncbi.nlm.nih.gov/gene/?term=27258 "SMX4, USS2, YLR438C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009103 27260 Plek2 http://www.ncbi.nlm.nih.gov/gene/?term=27260 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009104 27261 Dok3 http://www.ncbi.nlm.nih.gov/gene/?term=27261 "AI450713, Dokl " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009105 27275 Nufip1 http://www.ncbi.nlm.nih.gov/gene/?term=27275 Nufip mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009106 27277 Golga5 http://www.ncbi.nlm.nih.gov/gene/?term=27277 Ret-II mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009107 27280 Phlda3 http://www.ncbi.nlm.nih.gov/gene/?term=27280 Tih1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009108 27287 VENTX http://www.ncbi.nlm.nih.gov/gene/?term=27287 "HPX42B, NA88A2, VENTX " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009109 27287 VENTX http://www.ncbi.nlm.nih.gov/gene/?term=27287 "HPX42B, NA88A2, VENTX " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009110 27289 RND1 http://www.ncbi.nlm.nih.gov/gene/?term=27289 "ARHS, RHO6, RHOS " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009111 27289 RND1 http://www.ncbi.nlm.nih.gov/gene/?term=27289 "ARHS, RHO6, RHOS " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009112 27290 SPINK4 http://www.ncbi.nlm.nih.gov/gene/?term=27290 "HEL136, PEC-60, PEC60 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009113 27290 SPINK4 http://www.ncbi.nlm.nih.gov/gene/?term=27290 "HEL136, PEC-60, PEC60 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009114 27291 R3HCC1L http://www.ncbi.nlm.nih.gov/gene/?term=27291 "C10orf28, GIDRP86, GIDRP88, PSORT " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009115 27291 R3HCC1L http://www.ncbi.nlm.nih.gov/gene/?term=27291 "C10orf28, GIDRP86, GIDRP88, PSORT " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009116 27292 DIMT1 http://www.ncbi.nlm.nih.gov/gene/?term=27292 "DIM1, DIMT1L, HSA9761, HUSSY5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009117 27292 DIMT1 http://www.ncbi.nlm.nih.gov/gene/?term=27292 "DIM1L, HSA9761, HUSSY5, DIMT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009118 27297 CRCP http://www.ncbi.nlm.nih.gov/gene/?term=27297 "CGRP-RCP, CGRPRCP, RCP, RCP9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009119 2729 GCLC http://www.ncbi.nlm.nih.gov/gene/?term=2729 "GCL, GCS, GLCL, GLCLC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009120 2729 GCLC http://www.ncbi.nlm.nih.gov/gene/?term=2729 "GCL, GCS, GLCL, GLCLC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009121 272 AMPD3 http://www.ncbi.nlm.nih.gov/gene/?term=272 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009122 27301 APEX2 http://www.ncbi.nlm.nih.gov/gene/?term=27301 "APE2, APEXL2, XTH2, ZGRF2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009123 27303 RBMS3 http://www.ncbi.nlm.nih.gov/gene/?term=27303 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009124 27304 MOCS3 http://www.ncbi.nlm.nih.gov/gene/?term=27304 UBA4 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009125 27304 MOCS3 http://www.ncbi.nlm.nih.gov/gene/?term=27304 UBA4 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009126 27309 ZNF330 http://www.ncbi.nlm.nih.gov/gene/?term=27309 "HSA6591, NOA36 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009127 27309 ZNF330 http://www.ncbi.nlm.nih.gov/gene/?term=27309 "HSA6591, NOA36 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009128 2730 GCLM http://www.ncbi.nlm.nih.gov/gene/?term=2730 GLCLR mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009129 2730 GCLM http://www.ncbi.nlm.nih.gov/gene/?term=2730 GLCLR mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009130 27315 PGAP2 http://www.ncbi.nlm.nih.gov/gene/?term=27315 "CWH43-N, FRAG1, HPMRS3, MRT17, MRT21 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009131 27316 RBMX http://www.ncbi.nlm.nih.gov/gene/?term=27316 "HNRNPG, HNRPG, MRXS11, RBMXP1, RBMXRT, RNMX, hnRNP-G " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009132 27316 RBMX http://www.ncbi.nlm.nih.gov/gene/?term=27316 "HNRNPG, HNRPG, MRXS11P1, RBMXRT, RNMX, hnRNP-G, RBMX " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009133 2731 GLDC http://www.ncbi.nlm.nih.gov/gene/?term=2731 "GCE, GCSP, HYGN1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009134 27327 TNRC6A http://www.ncbi.nlm.nih.gov/gene/?term=27327 "CAGH26, GW1, GW182, TNRC6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009135 27332 ZNF638 http://www.ncbi.nlm.nih.gov/gene/?term=27332 "NP220, ZFML, Zfp638 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009136 27333 GOLIM4 http://www.ncbi.nlm.nih.gov/gene/?term=27333 "GIMPC, GOLPH4, GPP130, P138 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009137 27333 GOLIM4 http://www.ncbi.nlm.nih.gov/gene/?term=27333 "GIMPC, GOLPH4, GPP130, P138 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009138 27333 GOLIM4 http://www.ncbi.nlm.nih.gov/gene/?term=27333 "GIMPC, GOLPH4, GPP130, P138 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009139 27335 EIF3K http://www.ncbi.nlm.nih.gov/gene/?term=27335 "ARG134, EIF3-p28, EIF3S12, HSPC029, M9, MSTP001, PLAC-24, PLAC24, PRO1474, PTD001 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009140 27335 EIF3K http://www.ncbi.nlm.nih.gov/gene/?term=27335 "ARG134, EIF3-p28, EIF3S12, HSPC029, M9, MSTP001, PLAC-24, PLAC24, PRO1474, PTD001 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009141 27335 EIF3K http://www.ncbi.nlm.nih.gov/gene/?term=27335 "ARG134, EIF3-p28, EIF3S12, HSPC029, M9, MSTP001, PLAC-24, PLAC24, PRO1474, PTD001 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009142 27336 HTATSF1 http://www.ncbi.nlm.nih.gov/gene/?term=27336 "TAT-SF1, TATSF1, dJ196E23.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009143 27338 UBE2S http://www.ncbi.nlm.nih.gov/gene/?term=27338 "E2-EPF, E2EPF, EPF5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009144 27338 UBE2S http://www.ncbi.nlm.nih.gov/gene/?term=27338 "E2-EPF, E2EPF, EPF5 " mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00009145 27339 PRPF19 http://www.ncbi.nlm.nih.gov/gene/?term=27339 "NMP200, PRP19, PSO4, SNEV, UBOX4, hPSO4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009146 2733 GLE1 http://www.ncbi.nlm.nih.gov/gene/?term=2733 "GLE1L, LCCS, LCCS1, hGLE1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009147 2733 GLE1 http://www.ncbi.nlm.nih.gov/gene/?term=2733 "GLE1L, LCCS, LCCS1, hGLE1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009148 27340 UTP20 http://www.ncbi.nlm.nih.gov/gene/?term=27340 "1A6/DRIM, DRIM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009149 27340 UTP20 http://www.ncbi.nlm.nih.gov/gene/?term=27340 "1A6/DRIM, DRIM " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009150 27340 UTP20 http://www.ncbi.nlm.nih.gov/gene/?term=27340 "1A6/DRIM, DRIM " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009151 27340 UTP20 http://www.ncbi.nlm.nih.gov/gene/?term=27340 "1A6/DRIM, DRIM " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009152 27341 RRP7A http://www.ncbi.nlm.nih.gov/gene/?term=27341 "BK126B4.3, CGI-96 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009153 27342 RABGEF1 http://www.ncbi.nlm.nih.gov/gene/?term=27342 "RABEX5, RAP1, rabex-5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009154 27345 KCNMB4 http://www.ncbi.nlm.nih.gov/gene/?term=27345 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009155 27346 TMEM97 http://www.ncbi.nlm.nih.gov/gene/?term=27346 MAC30 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009156 27346 TMEM97 http://www.ncbi.nlm.nih.gov/gene/?term=27346 MAC30 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009157 27346 TMEM97 http://www.ncbi.nlm.nih.gov/gene/?term=27346 MAC30 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009158 27347 STK39 http://www.ncbi.nlm.nih.gov/gene/?term=27347 "DCHT, PASK, SPAK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009159 27347 STK39 http://www.ncbi.nlm.nih.gov/gene/?term=27347 "DCHT, PASK, SPAK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009160 27348 TOR1B http://www.ncbi.nlm.nih.gov/gene/?term=27348 DQ1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009161 27348 TOR1B http://www.ncbi.nlm.nih.gov/gene/?term=27348 DQ1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009162 27348 TOR1B http://www.ncbi.nlm.nih.gov/gene/?term=27348 DQ1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009163 27348 TOR1B http://www.ncbi.nlm.nih.gov/gene/?term=27348 DQ1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009164 27349 MCAT http://www.ncbi.nlm.nih.gov/gene/?term=27349 "FASN2C, MCT, MT, NET62, fabD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009165 2734 GLG1 http://www.ncbi.nlm.nih.gov/gene/?term=2734 "CFR-1, ESL-1, MG-160, MG160 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009166 2734 GLG1 http://www.ncbi.nlm.nih.gov/gene/?term=2734 "CFR-1, ESL-1, MG-160, MG160 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009167 27351 DESI1 http://www.ncbi.nlm.nih.gov/gene/?term=27351 "D15Wsu75e, DESI2, DJ347H13.4, DeSI-1, FAM152B, PPPDE2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009168 27352 SGSM3 http://www.ncbi.nlm.nih.gov/gene/?term=27352 "MAP, RABGAP5, RUSC3, RUTBC3, RabGAP-5, rabGAPLP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009169 27352 SGSM3 http://www.ncbi.nlm.nih.gov/gene/?term=27352 "MAP, RABGAP5, RUSC3, RUTBC3, RabGAP-5, rabGAPLP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009170 27361 Msrb1 http://www.ncbi.nlm.nih.gov/gene/?term=27361 "D17Wsu82e, SELX, SelR, Sepr, Sepx1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009171 27362 Dnajb9 http://www.ncbi.nlm.nih.gov/gene/?term=27362 "AA408011, AA673251, AA673481, AW556981, ERdj4, Mdg1, mDj7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009172 27366 Txnl4a http://www.ncbi.nlm.nih.gov/gene/?term=27366 "D18Wsu98e, Dim1, ENSMUSG00000057130, Txnl4, U5-15kD, U5-15kDa " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009173 27367 Rpl3 http://www.ncbi.nlm.nih.gov/gene/?term=27367 "F2, J1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00009174 27367 Rpl3 http://www.ncbi.nlm.nih.gov/gene/?term=27367 "F2, J1 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00009175 27368 Tbl2 http://www.ncbi.nlm.nih.gov/gene/?term=27368 "C76179, WS-bTRP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009176 2736 GLI2 http://www.ncbi.nlm.nih.gov/gene/?term=2736 "CJS, HPE9, PHS2, THP1, THP2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009177 27370 Rps26 http://www.ncbi.nlm.nih.gov/gene/?term=27370 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00009178 27376 Slc25a10 http://www.ncbi.nlm.nih.gov/gene/?term=27376 Dic mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009179 27377 Yme1l1 http://www.ncbi.nlm.nih.gov/gene/?term=27377 "FtsH1, Ftsh " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009180 2737 GLI3 http://www.ncbi.nlm.nih.gov/gene/?term=2737 "ACLS, GCPS-190, GLI3FL, PAP-A, PAPA, PAPA1, PAPB, PHS, PPDIV, GLI3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009181 27392 Pign http://www.ncbi.nlm.nih.gov/gene/?term=27392 "Gm20308, PIG-N " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009182 27398 Mrpl2 http://www.ncbi.nlm.nih.gov/gene/?term=27398 "CGI-22, L2mt, MRP-L14, MRP-L2, Rpml14 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009183 2739 GLO1 http://www.ncbi.nlm.nih.gov/gene/?term=2739 "GLOD1, GLYI, HEL-S-74 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009184 2739 GLO1 http://www.ncbi.nlm.nih.gov/gene/?term=2739 "GLOD1, GLYI, HEL-S-74 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009185 2739 GLO1 http://www.ncbi.nlm.nih.gov/gene/?term=2739 "GLOD1, GLYI, HEL-S-74 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009186 273 AMPH http://www.ncbi.nlm.nih.gov/gene/?term=273 AMPH1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009187 27401 Skp2 http://www.ncbi.nlm.nih.gov/gene/?term=27401 "4930500A04Rik, FBXL1, FWD1, p45 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009188 27418 Mkln1 http://www.ncbi.nlm.nih.gov/gene/?term=27418 "A130067F06Rik, AU015903, BB154892 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009189 27430 MAT2B http://www.ncbi.nlm.nih.gov/gene/?term=27430 "MAT-II, MATIIbeta, Nbla02999, SDR23E1, TGR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009190 27430 MAT2B http://www.ncbi.nlm.nih.gov/gene/?term=27430 "MAT-II, MATIIbeta, Nbla02999, SDR23E1, TGR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009191 27433 TOR2A http://www.ncbi.nlm.nih.gov/gene/?term=27433 TORP1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009192 27436 EML4 http://www.ncbi.nlm.nih.gov/gene/?term=27436 "C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009193 27436 EML4 http://www.ncbi.nlm.nih.gov/gene/?term=27436 "C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009194 27436 EML4 http://www.ncbi.nlm.nih.gov/gene/?term=27436 "C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009195 27439 CECR6 http://www.ncbi.nlm.nih.gov/gene/?term=27439 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009196 27440 CECR5 http://www.ncbi.nlm.nih.gov/gene/?term=27440 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009197 2744 GLS http://www.ncbi.nlm.nih.gov/gene/?term=2744 "AAD20, GAC, GAM, GLS1, KGA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009198 2744 GLS http://www.ncbi.nlm.nih.gov/gene/?term=2744 "AAD20, GAC, GAM1, KGA, GLS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009199 2744 GLS http://www.ncbi.nlm.nih.gov/gene/?term=2744 "AAD20, GAC, GAM1, KGA, GLS " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009200 2745 GLRX http://www.ncbi.nlm.nih.gov/gene/?term=2745 "GRX, GRX1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009201 2745 GLRX http://www.ncbi.nlm.nih.gov/gene/?term=2745 "GRX, GRX1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009202 2745 GLRX http://www.ncbi.nlm.nih.gov/gene/?term=2745 "GRX, GRX1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009203 2745 GLRX http://www.ncbi.nlm.nih.gov/gene/?term=2745 "GRX, GRX1 " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00009204 2746 GLUD1 http://www.ncbi.nlm.nih.gov/gene/?term=2746 "GDH, GDH1, GLUD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009205 2746 GLUD1 http://www.ncbi.nlm.nih.gov/gene/?term=2746 "GDH, GDH1, GLUD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009206 2747 GLUD2 http://www.ncbi.nlm.nih.gov/gene/?term=2747 "GDH2, GLUDP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009207 27493 A230006K03Rik http://www.ncbi.nlm.nih.gov/gene/?term=27493 "CAG-3, CAG8, D0Kist2, Gm7414 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009208 274 BIN1 http://www.ncbi.nlm.nih.gov/gene/?term=274 "AMPH2, AMPHL, SH3P9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009209 274 BIN1 http://www.ncbi.nlm.nih.gov/gene/?term=274 "AMPH2, AMPHL, SH3P9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009210 2752 GLUL http://www.ncbi.nlm.nih.gov/gene/?term=2752 "GLNS, GS, PIG43, PIG59 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009211 275 AMT http://www.ncbi.nlm.nih.gov/gene/?term=275 "GCE, GCST, GCVT, NKH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009212 2760 GM2A http://www.ncbi.nlm.nih.gov/gene/?term=2760 "GM2-AP, SAP-3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009213 2760 GM2A http://www.ncbi.nlm.nih.gov/gene/?term=2760 "GM2-AP, SAP-3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009214 2760 GM2A http://www.ncbi.nlm.nih.gov/gene/?term=2760 "GM2-AP, SAP-3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009215 2760 GM2A http://www.ncbi.nlm.nih.gov/gene/?term=2760 "GM2-AP, SAP-3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009216 2760 GM2A http://www.ncbi.nlm.nih.gov/gene/?term=2760 "GM2-AP, SAP-3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009217 2762 GMDS http://www.ncbi.nlm.nih.gov/gene/?term=2762 "GMD, SDR3E1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009218 2762 GMDS http://www.ncbi.nlm.nih.gov/gene/?term=2762 "GMD, SDR3E1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009219 2762 GMDS http://www.ncbi.nlm.nih.gov/gene/?term=2762 "GMD, SDR3E1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009220 27632 Nelfe http://www.ncbi.nlm.nih.gov/gene/?term=27632 "D17H6S45, NELF-E, RD, Rdbp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009221 2764 GMFB http://www.ncbi.nlm.nih.gov/gene/?term=2764 GMF mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009222 2766 GMPR http://www.ncbi.nlm.nih.gov/gene/?term=2766 "GMPR 1, GMPR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009223 276770 Eif5a http://www.ncbi.nlm.nih.gov/gene/?term=276770 "AA410058, D19Wsu54e, Eif4d1, eIF-4D, eIF-5A, eIF-5A-1, eIF-5A1, Eif5a " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00009224 2767 GNA11 http://www.ncbi.nlm.nih.gov/gene/?term=2767 "FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009225 2767 GNA11 http://www.ncbi.nlm.nih.gov/gene/?term=2767 "FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009226 2767 GNA11 http://www.ncbi.nlm.nih.gov/gene/?term=2767 "FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009227 2768951 CG33217 http://www.ncbi.nlm.nih.gov/gene/?term=2768951 "Dmel_ BcDNA:RE15216, Dmel\CG33217 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00009228 2768961 CG7369 http://www.ncbi.nlm.nih.gov/gene/?term=2768961 Dmel_ Dmel\CG7369 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00009229 2768996 CG33229 http://www.ncbi.nlm.nih.gov/gene/?term=2768996 "Dmel_ CG16971, CG32492, Dmel\CG33229 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00009230 2768 GNA12 http://www.ncbi.nlm.nih.gov/gene/?term=2768 "NNX3, RMP, gep " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009231 276920 Ccdc42 http://www.ncbi.nlm.nih.gov/gene/?term=276920 A530001H01Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009232 2770 GNAI1 http://www.ncbi.nlm.nih.gov/gene/?term=2770 Gi mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009233 2771 GNAI2 http://www.ncbi.nlm.nih.gov/gene/?term=2771 "GIPB, H_LUCA15.1, H_LUCA16.1, GNAI2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009234 277250 Kdm3b http://www.ncbi.nlm.nih.gov/gene/?term=277250 "5830462I21Rik, JHDM2B, Jmjd1b, mKIAA1082 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009235 277328 Trpa1 http://www.ncbi.nlm.nih.gov/gene/?term=277328 "Anktm1, TRPA1b " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009236 2773 GNAI3 http://www.ncbi.nlm.nih.gov/gene/?term=2773 "87U6, ARCND1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009237 2773 GNAI3 http://www.ncbi.nlm.nih.gov/gene/?term=2773 "87U6, ARCND1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009238 2773 GNAI3 http://www.ncbi.nlm.nih.gov/gene/?term=2773 "87U6, ARCND1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009239 2773 GNAI3 http://www.ncbi.nlm.nih.gov/gene/?term=2773 "87U6, ARCND1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009240 2773 GNAI3 http://www.ncbi.nlm.nih.gov/gene/?term=2773 "87U6, ARCND1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009241 277432 Vstm2l http://www.ncbi.nlm.nih.gov/gene/?term=277432 Gm691 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009242 277463 Gpr107 http://www.ncbi.nlm.nih.gov/gene/?term=277463 "9930033D15Rik, AI790205, C530034M11, mKIAA1624 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00009243 2774 GNAL http://www.ncbi.nlm.nih.gov/gene/?term=2774 DYT25 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009244 27756 Lsm2 http://www.ncbi.nlm.nih.gov/gene/?term=27756 "D17H6S56E-2, D17H6S56E2, Dmapl, Dmpkap, G7b, Sm-X5, SmX5, snRNP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009245 2775 GNAO1 http://www.ncbi.nlm.nih.gov/gene/?term=2775 "EIEE17, G-ALPHA-o, GNAO " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009246 27762 Vwa7 http://www.ncbi.nlm.nih.gov/gene/?term=27762 "C6orf27, D17H6S56E-3, G7c, NG37 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009247 2776 GNAQ http://www.ncbi.nlm.nih.gov/gene/?term=2776 "CMC1, G-ALPHA-q, GAQ, SWS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009248 2778 GNAS http://www.ncbi.nlm.nih.gov/gene/?term=2778 "AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, POH, SCG6, SgVI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009249 2778 GNAS http://www.ncbi.nlm.nih.gov/gene/?term=2778 "AHO, C20orf451, GPSA, GSA, GSP, NESP, POH, SCG6, SgVI, GNAS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009250 2778 GNAS http://www.ncbi.nlm.nih.gov/gene/?term=2778 "AHO, C20orf451, GPSA, GSA, GSP, NESP, POH, SCG6, SgVI, GNAS " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009251 2778 GNAS http://www.ncbi.nlm.nih.gov/gene/?term=2778 "AHO, C20orf451, GPSA, GSA, GSP, NESP, POH, SCG6, SgVI, GNAS " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009252 2781 GNAZ http://www.ncbi.nlm.nih.gov/gene/?term=2781 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009253 278240 Spin2c http://www.ncbi.nlm.nih.gov/gene/?term=278240 "BC068162, SPIN-2C, Spin2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009254 278279 Tmtc2 http://www.ncbi.nlm.nih.gov/gene/?term=278279 "8430438D04Rik, D330034A10Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009255 2782 GNB1 http://www.ncbi.nlm.nih.gov/gene/?term=2782 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009256 2782 GNB1 http://www.ncbi.nlm.nih.gov/gene/?term=2782 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009257 278304 Zfp385c http://www.ncbi.nlm.nih.gov/gene/?term=278304 "A930006D11Rik, Znf385c " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009258 2783 GNB2 http://www.ncbi.nlm.nih.gov/gene/?term=2783 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009259 2783 GNB2 http://www.ncbi.nlm.nih.gov/gene/?term=2783 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009260 278507 Wfikkn2 http://www.ncbi.nlm.nih.gov/gene/?term=278507 "2610304F08Rik, AY100450, Gasp1, WFIKKNRP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009261 278725 E130310I04Rik http://www.ncbi.nlm.nih.gov/gene/?term=278725 A930019C19Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009262 2787 GNG5 http://www.ncbi.nlm.nih.gov/gene/?term=2787 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009263 2787 GNG5 http://www.ncbi.nlm.nih.gov/gene/?term=2787 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009264 27886 Dgcr14 http://www.ncbi.nlm.nih.gov/gene/?term=27886 "AI462402, D16H22S1269E, Dgcr1, Dgsi, ES2, Es2el " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009265 2790 GNG10 http://www.ncbi.nlm.nih.gov/gene/?term=2790 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009266 2794 GNL1 http://www.ncbi.nlm.nih.gov/gene/?term=2794 HSR1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009267 2794 GNL1 http://www.ncbi.nlm.nih.gov/gene/?term=2794 HSR1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009268 279766 Rhbdd3 http://www.ncbi.nlm.nih.gov/gene/?term=279766 Ptag mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009269 27981 Rsrp1 http://www.ncbi.nlm.nih.gov/gene/?term=27981 "2700043I21Rik, D4Ucla2, D4Wsu53e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009270 27984 Efhd2 http://www.ncbi.nlm.nih.gov/gene/?term=27984 "2600015J22Rik, AA408606, D4Wsu27e " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009271 27998 Exosc5 http://www.ncbi.nlm.nih.gov/gene/?term=27998 D7Wsu180e mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009272 27999 Fam3c http://www.ncbi.nlm.nih.gov/gene/?term=27999 "D6Wsu176e, Ilei " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009273 2799 GNS http://www.ncbi.nlm.nih.gov/gene/?term=2799 G6S mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009274 2799 GNS http://www.ncbi.nlm.nih.gov/gene/?term=2799 G6S mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009275 2799 GNS http://www.ncbi.nlm.nih.gov/gene/?term=2799 G6S mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009276 2799 GNS http://www.ncbi.nlm.nih.gov/gene/?term=2799 G6S mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009277 2799 GNS http://www.ncbi.nlm.nih.gov/gene/?term=2799 G6S mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009278 27 ABL2 http://www.ncbi.nlm.nih.gov/gene/?term=27 "ABLL, ARG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009279 28000 Prpf19 http://www.ncbi.nlm.nih.gov/gene/?term=28000 "AA617263, AL024362, D19Wsu55e, NMP200, PSO4, Prp19, Snev " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009280 28000 Prpf19 http://www.ncbi.nlm.nih.gov/gene/?term=28000 "AA617263, AL024362, D19Wsu55e, NMP200, PSO4, Prp19, Snev " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00009281 2800 GOLGA1 http://www.ncbi.nlm.nih.gov/gene/?term=2800 golgin-97 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009282 28018 Ubfd1 http://www.ncbi.nlm.nih.gov/gene/?term=28018 "AI467302, D7Wsu105e, D7Wsu128e, Ubph " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009283 2802 GOLGA3 http://www.ncbi.nlm.nih.gov/gene/?term=2802 "GCP170, MEA-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009284 2802 GOLGA3 http://www.ncbi.nlm.nih.gov/gene/?term=2802 "GCP170, MEA-2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009285 2802 GOLGA3 http://www.ncbi.nlm.nih.gov/gene/?term=2802 "GCP170, MEA-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009286 2802 GOLGA3 http://www.ncbi.nlm.nih.gov/gene/?term=2802 "GCP170, MEA-2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009287 2802 GOLGA3 http://www.ncbi.nlm.nih.gov/gene/?term=2802 "GCP170, MEA-2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009288 28030 Gfm1 http://www.ncbi.nlm.nih.gov/gene/?term=28030 "AW545374, D3Wsu133e, Gfm " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009289 28036 Larp7 http://www.ncbi.nlm.nih.gov/gene/?term=28036 "C330027G06Rik, D3Wsu161e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009290 2803 GOLGA4 http://www.ncbi.nlm.nih.gov/gene/?term=2803 "CRPF46, GCP2, GOLG, MU-RMS-40.18, p230 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009291 2803 GOLGA4 http://www.ncbi.nlm.nih.gov/gene/?term=2803 "CRPF46, GCP2, GOLG, MU-RMS-40.18, p230 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009292 2803 GOLGA4 http://www.ncbi.nlm.nih.gov/gene/?term=2803 "CRPF46, GCP2, GOLG, MU-RMS-40.18, p230 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009293 28040 D6Wsu163e http://www.ncbi.nlm.nih.gov/gene/?term=28040 C12orf4 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009294 28042 Ept1 http://www.ncbi.nlm.nih.gov/gene/?term=28042 "4933402G07Rik, AI448296, AI452230, C79563, D5Wsu178e, SELI, mKIAA1724 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009295 2804 GOLGB1 http://www.ncbi.nlm.nih.gov/gene/?term=2804 "GCP, GCP372, GOLIM1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009296 2804 GOLGB1 http://www.ncbi.nlm.nih.gov/gene/?term=2804 "GCP, GCP372, GOLIM1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009297 2805 GOT1 http://www.ncbi.nlm.nih.gov/gene/?term=2805 "AST1, ASTQTL1, GIG18, cAspAT, cCAT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009298 2805 GOT1 http://www.ncbi.nlm.nih.gov/gene/?term=2805 "AST1, ASTQTL1, GIG18, cAspAT, cCAT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009299 2805 GOT1 http://www.ncbi.nlm.nih.gov/gene/?term=2805 "AST1, ASTQTL1, GIG18, cAspAT, cCAT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009300 280636 C11orf31 http://www.ncbi.nlm.nih.gov/gene/?term=280636 "C17orf10, SELH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009301 2806 GOT2 http://www.ncbi.nlm.nih.gov/gene/?term=2806 "KAT4, KATIV, mitAAT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009302 2806 GOT2 http://www.ncbi.nlm.nih.gov/gene/?term=2806 "KAT4, KATIV, mitAAT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009303 28071 Twistnb http://www.ncbi.nlm.nih.gov/gene/?term=28071 "2410173G11, 2810024J17Rik, D16Wsu83e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009304 2810 SFN http://www.ncbi.nlm.nih.gov/gene/?term=2810 YWHAS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009305 28114 Nsun2 http://www.ncbi.nlm.nih.gov/gene/?term=28114 "D13Wsu123e, Misu " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009306 2812 GP1BB http://www.ncbi.nlm.nih.gov/gene/?term=2812 "BDPLT1, BS, CD42C, GPIBB, GPIbbeta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009307 28135 Cep63 http://www.ncbi.nlm.nih.gov/gene/?term=28135 "4921501M07, AL450317.13gm1, AW107703, CD20R, D9Mgc41, D9Mgc48e, ET2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009308 2813 GP2 http://www.ncbi.nlm.nih.gov/gene/?term=2813 ZAP75 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009309 2815 GP9 http://www.ncbi.nlm.nih.gov/gene/?term=2815 "CD42a, GPIX " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009310 2817 GPC1 http://www.ncbi.nlm.nih.gov/gene/?term=2817 glypican mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009311 2817 GPC1 http://www.ncbi.nlm.nih.gov/gene/?term=2817 glypican mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009312 28185 Tomm70a http://www.ncbi.nlm.nih.gov/gene/?term=28185 "2610044B22Rik, D16Ium22, D16Ium22e, D16Wsu109e, Tom70, mKIAA0719 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009313 2819 GPD1 http://www.ncbi.nlm.nih.gov/gene/?term=2819 "GPD-C, GPDH-C, HTGTI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009314 2820 GPD2 http://www.ncbi.nlm.nih.gov/gene/?term=2820 "GDH2, GPDM, mGPDH " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009315 2820 GPD2 http://www.ncbi.nlm.nih.gov/gene/?term=2820 "GDH2, GPDM, mGPDH " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009316 2821 GPI http://www.ncbi.nlm.nih.gov/gene/?term=2821 "AMF, GNPI, NLK, PGI, PHI, SA-36, SA36 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009317 2821 GPI http://www.ncbi.nlm.nih.gov/gene/?term=2821 "AMF, GNPI, NLK, PGI, PHI, SA-36, SA36 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009318 2821 GPI http://www.ncbi.nlm.nih.gov/gene/?term=2821 "AMF, GNPI, NLK, PGI, PHI, SA-36, SA36 " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00009319 28227 PPP2R3B http://www.ncbi.nlm.nih.gov/gene/?term=28227 "NYREN8, PPP2R3L, PPP2R3LY, PR48 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009320 2822 GPLD1 http://www.ncbi.nlm.nih.gov/gene/?term=2822 "GPIPLD, GPIPLDM, PIGPLD, PIGPLD1, PLD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009321 28231 SLCO4A1 http://www.ncbi.nlm.nih.gov/gene/?term=28231 "OATP-E, OATP1, OATP4A1, OATPE, OATPRP1, POAT, SLC21A12 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009322 28231 SLCO4A1 http://www.ncbi.nlm.nih.gov/gene/?term=28231 "OATP-E, OATP1, OATP4A1, OATPE, OATPRP1, POAT, SLC21A12 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009323 28240 Trpm2 http://www.ncbi.nlm.nih.gov/gene/?term=28240 "9830168K16Rik, C79133, LTRPC2, TRPC7, Trp7, Trrp7 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00009324 2824 GPM6B http://www.ncbi.nlm.nih.gov/gene/?term=2824 M6B mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009325 2825 GPR1 http://www.ncbi.nlm.nih.gov/gene/?term=2825 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009326 282679 AQP11 http://www.ncbi.nlm.nih.gov/gene/?term=282679 AQPX1 mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00009327 282679 AQP11 http://www.ncbi.nlm.nih.gov/gene/?term=282679 AQPX1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009328 282809 POC1B http://www.ncbi.nlm.nih.gov/gene/?term=282809 "CORD20, PIX1, TUWD12, WDR51B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009329 28295 D10Jhu81e http://www.ncbi.nlm.nih.gov/gene/?term=28295 "C21orf33, ES1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009330 282969 FUOM http://www.ncbi.nlm.nih.gov/gene/?term=282969 "C10orf125, FUCU, FucM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009331 282973 JAKMIP3 http://www.ncbi.nlm.nih.gov/gene/?term=282973 "C10orf14, C10orf39, Jamip3, NECC2, bA140A10.5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009332 282974 STK32C http://www.ncbi.nlm.nih.gov/gene/?term=282974 "PKE, YANK3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009333 282991 BLOC1S2 http://www.ncbi.nlm.nih.gov/gene/?term=282991 "BLOS2, BORCS2, CEAP, CEAP11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009334 2829 XCR1 http://www.ncbi.nlm.nih.gov/gene/?term=2829 "CCXCR1, GPR5 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009335 283078 MKX http://www.ncbi.nlm.nih.gov/gene/?term=283078 "C10orf48, IFRX, IRXL1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009336 283104 SBF2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=283104 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009337 283106 CSNK2A3 http://www.ncbi.nlm.nih.gov/gene/?term=283106 CSNK2A1P mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009338 283120 H19 http://www.ncbi.nlm.nih.gov/gene/?term=283120 "ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009339 283120 H19 http://www.ncbi.nlm.nih.gov/gene/?term=283120 "ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 " lncRNA Homo sapiens 1688465 Cytoplasm Hepatoma cell Next generation sequencing Cellular fractionation showed that H19 RNA is cytoplasmic but not associated with the translational machinery. RLID00009340 283120 H19 http://www.ncbi.nlm.nih.gov/gene/?term=283120 "ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 " lncRNA Homo sapiens 25332394 Cytoplasm - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/H19/ RLID00009341 283120 H19 http://www.ncbi.nlm.nih.gov/gene/?term=283120 "ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 " lncRNA Homo sapiens 23898077 Circulating Plasma RT-PCR "Analysis showed that samples with pre-amplification had a higher level of linearity in the reverse transcription polymerase chain reaction (RT-PCR) assay than those without pre-amplification. Plasma H19 levels were significantly higher in patients than in healthy controls. Plasma H19 levels were significantly reduced in postoperative samples. Conclusion: Circulating lncRNAs can be detectable in plasma, and the detection of circulating lncRNAs may provide new complementary tumor markers for gastric cancer. " RLID00009342 283120 H19 http://www.ncbi.nlm.nih.gov/gene/?term=283120 "ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 " lncRNA Homo sapiens 18794369 Nucleus Breast cancer cell qRT-PCR This activity occurs antisense to the H19 gene and has the potential to produce a single 120-kb transcript that we called the 91H RNA. This nuclear and short-lived RNA is not imprinted in mouse but is expressed predominantly from the maternal allele in both mice and humans within the H19 gene region. RLID00009343 283120 H19 http://www.ncbi.nlm.nih.gov/gene/?term=283120 "ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 " lncRNA Homo sapiens 25332394 Nucleus - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/H19/ RLID00009344 283120 H19 http://www.ncbi.nlm.nih.gov/gene/?term=283120 "ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 " lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009345 283120 H19 http://www.ncbi.nlm.nih.gov/gene/?term=283120 "ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 " lncRNA Homo sapiens 22955988 Cytoplasm Brain Microarray "We examined the subcellular location of a number of well-known lncRNAs (Fig. 8D). Unsurprisingly, the X-chromosome inactivating transcript XIST was extremely highly enriched in the nucleus for all cells we examined (with a maximum enrichment of 273-fold in the nucleus of GM12878 cells) (Fig. 8D). Other regulatory lncRNAs such as GAS5, LINC00568 (also known as ncRNA-a1), CYP4A22-AS1 (also known as ncRNA-a3), MIAT, and MEG3 were nuclear enriched in at least two different cell types, consistent with their reported roles in gene regulation. Other transcripts, including the bifunctional transcript SRA1, which acts as both a regulatory RNA and a protein-coding sequence, have more variable subcellular location depending on cell type. As reported previously, the H19 transcript is consistently enriched in the cytoplasm, especially when comparing with the chromatin fraction (cytoplasmic/chromatin enrichment 167-fold). " RLID00009346 283130 SLC25A45 http://www.ncbi.nlm.nih.gov/gene/?term=283130 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009347 283130 SLC25A45 http://www.ncbi.nlm.nih.gov/gene/?term=283130 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009348 283131 NEAT1 http://www.ncbi.nlm.nih.gov/gene/?term=283131 "LINC00084, NCRNA00084, TncRNA, VINC " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009349 283131 NEAT1 http://www.ncbi.nlm.nih.gov/gene/?term=283131 "LINC00084, NCRNA00084, TncRNA, VINC " lncRNA Homo sapiens 17270048 Nucleus Fibroblast|Lymphoblast In situ hybridization "This screen identified no more than three transcripts; XIST, and two unique noncoding nuclear enriched abundant transcripts (NEAT) RNAs strikingly located less than 70 kb apart on human chromosome 11: NEAT1, a noncoding RNA from the locus encoding for TncRNA, and NEAT2 (also known as MALAT-1). " RLID00009350 283131 NEAT1 http://www.ncbi.nlm.nih.gov/gene/?term=283131 "LINC00084, NCRNA00084, TncRNA, VINC " lncRNA Homo sapiens 21128942 Nucleus Brain tissue qRT-PCR|Microarray Table 2: Long noncoding RNAs represented on Affymetrix U133 arrays that were reliably detected in human nucleus accumbens. An lncRNA was considered reliably detected in human NAcc if at least one probe corresponding to the transcript gave a specific signal in all control subjects. No transcripts undetected in the controls were consistently detected in drug abusers. Data are collected from Talbe 2. RLID00009351 283131 NEAT1 http://www.ncbi.nlm.nih.gov/gene/?term=283131 "LINC00084, NCRNA00084, TncRNA, VINC " lncRNA Homo sapiens 23835137 Nucleus HeLa cell Immunoblotting|RT-PCR "NEAT1_2 lncRNA may act as a scaffold of RNAs and RNA binding proteins in the nuclei of ALS motor neurons, thereby modulating the functions of ALS-associated RNA-binding proteins during the early phase of ALS. These findings provide the first evidence of a direct association between paraspeckle formation and a neurodegenerative disease, and may shed light on the development of novel therapeutic targets for the treatment of ALS. " RLID00009352 283131 NEAT1 http://www.ncbi.nlm.nih.gov/gene/?term=283131 "LINC00084, NCRNA00084, TncRNA, VINC " lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009353 283131 NEAT1 http://www.ncbi.nlm.nih.gov/gene/?term=283131 "LINC00084, NCRNA00084, TncRNA, VINC " lncRNA Homo sapiens 25415230 Nucleus Prostate cancer cell qRT-PCR NEAT1 was originally identified localized to subnuclear organelles called paraspeckles that are free of chromatin and function as repositories of edited RNA and a number of nuclear RNA-binding proteins5. RLID00009354 283131 NEAT1 http://www.ncbi.nlm.nih.gov/gene/?term=283131 "LINC00084, NCRNA00084, TncRNA, VINC " lncRNA Homo sapiens 25332394 Nucleus - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/NEAT1/ RLID00009355 283131 NEAT1 http://www.ncbi.nlm.nih.gov/gene/?term=283131 "LINC00084, NCRNA00084, TncRNA, VINC " lncRNA Homo sapiens 19217333 Nucleus HeLa cell In situ hybridization|qRT-PCR "Unlike other nuclear-retained RNAs, NEAT1 RNA is not A-I edited, consistent with a structural role in paraspeckles. " RLID00009356 283131 NEAT1 http://www.ncbi.nlm.nih.gov/gene/?term=283131 "LINC00084, NCRNA00084, TncRNA, VINC " lncRNA Homo sapiens 19716791 Nucleus HeLa cell In situ hybridization|qRT-PCR "Using in situ hybridization we demonstrated that hNEAT1 localizes to paraspeckles in HeLa cells. As shown in Fig. 3C, hNEAT1 RNA is restricted to a small number of large, distinct nuclear speckles in HeLa cell nuclei. " RLID00009357 283131 NEAT1 http://www.ncbi.nlm.nih.gov/gene/?term=283131 "LINC00084, NCRNA00084, TncRNA, VINC " lncRNA Homo sapiens 24280234 Nucleus Placenta qRT-PCR One candidate gene identified was the long non-coding RNA NEAT1 (nuclear paraspeckle assembly transcript 1). NEAT1 is the core component of a subnuclear structure called paraspeckle. RLID00009358 283219 KCTD21 http://www.ncbi.nlm.nih.gov/gene/?term=283219 KCASH2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009359 283229 CRACR2B http://www.ncbi.nlm.nih.gov/gene/?term=283229 EFCAB4A mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009360 283229 CRACR2B http://www.ncbi.nlm.nih.gov/gene/?term=283229 EFCAB4A mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009361 283232 TMEM80 http://www.ncbi.nlm.nih.gov/gene/?term=283232 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009362 283234 CCDC88B http://www.ncbi.nlm.nih.gov/gene/?term=283234 "BRLZ, CCDC88, HKRP3, gipie " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009363 283237 TTC9C http://www.ncbi.nlm.nih.gov/gene/?term=283237 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009364 283337 ZNF740 http://www.ncbi.nlm.nih.gov/gene/?term=283337 Zfp740 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009365 283373 ANKRD52 http://www.ncbi.nlm.nih.gov/gene/?term=283373 ANKRD33 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009366 283377 SPRYD4 http://www.ncbi.nlm.nih.gov/gene/?term=283377 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009367 283377 SPRYD4 http://www.ncbi.nlm.nih.gov/gene/?term=283377 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009368 283377 SPRYD4 http://www.ncbi.nlm.nih.gov/gene/?term=283377 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009369 283377 SPRYD4 http://www.ncbi.nlm.nih.gov/gene/?term=283377 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009370 283417 DPY19L2 http://www.ncbi.nlm.nih.gov/gene/?term=283417 "SPATA34, SPGF9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009371 283431 GAS2L3 http://www.ncbi.nlm.nih.gov/gene/?term=283431 G2L3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009372 283450 HECTD4 http://www.ncbi.nlm.nih.gov/gene/?term=283450 "C12orf51, POTAGE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009373 283459 GATC http://www.ncbi.nlm.nih.gov/gene/?term=283459 15E1.2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009374 283464 GXYLT1 http://www.ncbi.nlm.nih.gov/gene/?term=283464 GLT8D3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009375 283576 ZDHHC22 http://www.ncbi.nlm.nih.gov/gene/?term=283576 C14orf59 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009376 283578 TMED8 http://www.ncbi.nlm.nih.gov/gene/?term=283578 FAM15B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009377 283578 TMED8 http://www.ncbi.nlm.nih.gov/gene/?term=283578 FAM15B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009378 283578 TMED8 http://www.ncbi.nlm.nih.gov/gene/?term=283578 FAM15B mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009379 283579 C14orf178 http://www.ncbi.nlm.nih.gov/gene/?term=283579 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009380 283579 C14orf178 http://www.ncbi.nlm.nih.gov/gene/?term=283579 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009381 283596 SNHG10 http://www.ncbi.nlm.nih.gov/gene/?term=283596 "C14orf62, LINC00063, NCRNA00063 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009382 283596 SNHG10 http://www.ncbi.nlm.nih.gov/gene/?term=283596 "C14orf62, LINC00063, NCRNA00063 " lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009383 283635 FAM177A1 http://www.ncbi.nlm.nih.gov/gene/?term=283635 C14orf24 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009384 283635 FAM177A1 http://www.ncbi.nlm.nih.gov/gene/?term=283635 C14orf24 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009385 283638 CEP170B http://www.ncbi.nlm.nih.gov/gene/?term=283638 "CEP170R, FAM68C, KIAA0284 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009386 283643 C14orf80 http://www.ncbi.nlm.nih.gov/gene/?term=283643 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009387 283673 EWSAT1 http://www.ncbi.nlm.nih.gov/gene/?term=283673 "LINC00277, NCRNA00277, TMEM84 " lncRNA Homo sapiens 25401475 Nucleus Ewing sarcoma cell|osteosarcoma cell RT-PCR "Notably, EWSAT1 is expressed both in the nucleus and in the cytoplasm, suggesting that it may have complex roles in gene regulation (Supplemental Figure 4, E and F). " RLID00009388 283673 EWSAT1 http://www.ncbi.nlm.nih.gov/gene/?term=283673 "LINC00277, NCRNA00277, TMEM84 " lncRNA Homo sapiens 25401475 Cytoplasm Ewing sarcoma cell|osteosarcoma cell RT-PCR "Notably, EWSAT1 is expressed both in the nucleus and in the cytoplasm, suggesting that it may have complex roles in gene regulation (Supplemental Figure 4, E and F). " RLID00009389 283677 REC114 http://www.ncbi.nlm.nih.gov/gene/?term=283677 "C15orf60, CT147 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009390 283742 FAM98B http://www.ncbi.nlm.nih.gov/gene/?term=283742 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009391 283748 PLA2G4D http://www.ncbi.nlm.nih.gov/gene/?term=283748 cPLA2delta mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009392 283748 PLA2G4D http://www.ncbi.nlm.nih.gov/gene/?term=283748 cPLA2delta mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009393 283807 FBXL22 http://www.ncbi.nlm.nih.gov/gene/?term=283807 Fbl22 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009394 283807 FBXL22 http://www.ncbi.nlm.nih.gov/gene/?term=283807 Fbl22 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009395 283820 NOMO2 http://www.ncbi.nlm.nih.gov/gene/?term=283820 "Nomo, PM5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009396 283871 PGP http://www.ncbi.nlm.nih.gov/gene/?term=283871 PGPase mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009397 283871 PGP http://www.ncbi.nlm.nih.gov/gene/?term=283871 PGPase mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009398 283899 INO80E http://www.ncbi.nlm.nih.gov/gene/?term=283899 CCDC95 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009399 283899 INO80E http://www.ncbi.nlm.nih.gov/gene/?term=283899 CCDC95 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009400 283951 C16orf91 http://www.ncbi.nlm.nih.gov/gene/?term=283951 "CCSMST1, URLC5, gs103 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009401 283985 FADS6 http://www.ncbi.nlm.nih.gov/gene/?term=283985 FP18279 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009402 283989 TSEN54 http://www.ncbi.nlm.nih.gov/gene/?term=283989 "PCH2A, PCH4, PCH5, SEN54L, sen54 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009403 283989 TSEN54 http://www.ncbi.nlm.nih.gov/gene/?term=283989 "PCH2A, PCH4, PCH5, SEN54L, sen54 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009404 283991 UBALD2 http://www.ncbi.nlm.nih.gov/gene/?term=283991 FAM100B mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009405 283 ANG http://www.ncbi.nlm.nih.gov/gene/?term=283 "ALS9, HEL168, RAA1, RNASE4, RNASE5 " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00009406 284001 CCDC57 http://www.ncbi.nlm.nih.gov/gene/?term=284001 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009407 284001 CCDC57 http://www.ncbi.nlm.nih.gov/gene/?term=284001 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009408 284004 HEXDC http://www.ncbi.nlm.nih.gov/gene/?term=284004 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009409 284018 C17orf58 http://www.ncbi.nlm.nih.gov/gene/?term=284018 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009410 284018 C17orf58 http://www.ncbi.nlm.nih.gov/gene/?term=284018 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009411 284029 LINC00324 http://www.ncbi.nlm.nih.gov/gene/?term=284029 "C17orf44, NCRNA00324 " lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009412 284058 KANSL1 http://www.ncbi.nlm.nih.gov/gene/?term=284058 "CENP-36, KDVS, KIAA1267, MSL1v1, NSL1, hMSL1v1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009413 284058 KANSL1 http://www.ncbi.nlm.nih.gov/gene/?term=284058 "CENP-36, KDVS, KIAA1267, MSL1v1, NSL1, hMSL1v1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009414 284058 KANSL1 http://www.ncbi.nlm.nih.gov/gene/?term=284058 "CENP-36, KDVS, KIAA1267, MSL1v1, NSL1, hMSL1v1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009415 284086 NEK8 http://www.ncbi.nlm.nih.gov/gene/?term=284086 "JCK, NEK12A, NPHP9, RHPD2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009416 284086 NEK8 http://www.ncbi.nlm.nih.gov/gene/?term=284086 "JCK, NEK12A, NPHP9, RHPD2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009417 284098 PIGW http://www.ncbi.nlm.nih.gov/gene/?term=284098 "Gwt1, HPMRS5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009418 284098 PIGW http://www.ncbi.nlm.nih.gov/gene/?term=284098 "Gwt1, HPMRS5 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009419 284098 PIGW http://www.ncbi.nlm.nih.gov/gene/?term=284098 "Gwt1, HPMRS5 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009420 2840 GPR17 http://www.ncbi.nlm.nih.gov/gene/?term=2840 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009421 284106 CISD3 http://www.ncbi.nlm.nih.gov/gene/?term=284106 Miner2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009422 284110 GSDMA http://www.ncbi.nlm.nih.gov/gene/?term=284110 "FKSG9, GSDM, GSDM1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009423 284110 GSDMA http://www.ncbi.nlm.nih.gov/gene/?term=284110 "FKSG9, GSDM, GSDM1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009424 284111 SLC13A5 http://www.ncbi.nlm.nih.gov/gene/?term=284111 "EIEE25, NACT, mIndy " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009425 284119 PTRF http://www.ncbi.nlm.nih.gov/gene/?term=284119 "CAVIN, CAVIN1, CGL4, FKSG13, cavin-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009426 284119 PTRF http://www.ncbi.nlm.nih.gov/gene/?term=284119 "CAVIN, CAVIN1, CGL4, FKSG13, cavin-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009427 284131 ENDOV http://www.ncbi.nlm.nih.gov/gene/?term=284131 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009428 284184 C17orf89 http://www.ncbi.nlm.nih.gov/gene/?term=284184 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009429 284184 C17orf89 http://www.ncbi.nlm.nih.gov/gene/?term=284184 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009430 284186 TMEM105 http://www.ncbi.nlm.nih.gov/gene/?term=284186 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009431 284186 TMEM105 http://www.ncbi.nlm.nih.gov/gene/?term=284186 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009432 284207 METRNL http://www.ncbi.nlm.nih.gov/gene/?term=284207 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009433 284257 BOD1L2 http://www.ncbi.nlm.nih.gov/gene/?term=284257 "BOD1P, FAM44C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009434 284273 ZADH2 http://www.ncbi.nlm.nih.gov/gene/?term=284273 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009435 284293 HMSD http://www.ncbi.nlm.nih.gov/gene/?term=284293 "ACC-6, ACC6, C18orf53, HSMD-v " mRNA Homo sapiens 17409267 Dendrite B-LCLs RT-PCR "Both HMSD-v and HMSD transcripts were selectively expressed at higher levels in mature dendritic cells and primary leukemia cells, especially those of myeloid lineage. " RLID00009436 2842 GPR19 http://www.ncbi.nlm.nih.gov/gene/?term=2842 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009437 284325 C19orf54 http://www.ncbi.nlm.nih.gov/gene/?term=284325 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009438 284325 C19orf54 http://www.ncbi.nlm.nih.gov/gene/?term=284325 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009439 284325 C19orf54 http://www.ncbi.nlm.nih.gov/gene/?term=284325 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009440 284349 ZNF283 http://www.ncbi.nlm.nih.gov/gene/?term=284349 "HZF19, HZF41 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009441 284349 ZNF283 http://www.ncbi.nlm.nih.gov/gene/?term=284349 "HZF19, HZF41 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009442 284352 PPP1R37 http://www.ncbi.nlm.nih.gov/gene/?term=284352 LRRC68 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009443 284361 EMC10 http://www.ncbi.nlm.nih.gov/gene/?term=284361 "C19orf63, HSM1, HSS1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009444 284361 EMC10 http://www.ncbi.nlm.nih.gov/gene/?term=284361 "C19orf63, HSM1, HSS1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009445 284403 WDR62 http://www.ncbi.nlm.nih.gov/gene/?term=284403 "C19orf14, MCPH2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009446 284439 SLC25A42 http://www.ncbi.nlm.nih.gov/gene/?term=284439 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009447 284565 NBPF15 http://www.ncbi.nlm.nih.gov/gene/?term=284565 "AB14, AG3, NBPF16 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009448 284565 NBPF15 http://www.ncbi.nlm.nih.gov/gene/?term=284565 "AB14, AG3, NBPF16 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009449 284611 FAM102B http://www.ncbi.nlm.nih.gov/gene/?term=284611 SYM-3B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009450 284613 CYB561D1 http://www.ncbi.nlm.nih.gov/gene/?term=284613 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009451 284613 CYB561D1 http://www.ncbi.nlm.nih.gov/gene/?term=284613 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009452 284613 CYB561D1 http://www.ncbi.nlm.nih.gov/gene/?term=284613 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009453 284656 EPHA10 http://www.ncbi.nlm.nih.gov/gene/?term=284656 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009454 284695 ZNF326 http://www.ncbi.nlm.nih.gov/gene/?term=284695 "ZAN75, ZIRD, Zfp326, dJ871E2.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009455 284716 RIMKLA http://www.ncbi.nlm.nih.gov/gene/?term=284716 "FAM80A, NAAGS, NAAGS-II " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009456 284801 MIR663AHG http://www.ncbi.nlm.nih.gov/gene/?term=284801 lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009457 284802 FRG1BP http://www.ncbi.nlm.nih.gov/gene/?term=284802 "C20orf80, FRG1B, bA348I14.2 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009458 284942 RPL23AP82 http://www.ncbi.nlm.nih.gov/gene/?term=284942 RPL23A_43_1761 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009459 284992 CCDC150 http://www.ncbi.nlm.nih.gov/gene/?term=284992 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009460 284996 RNF149 http://www.ncbi.nlm.nih.gov/gene/?term=284996 DNAPTP2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009461 284996 RNF149 http://www.ncbi.nlm.nih.gov/gene/?term=284996 DNAPTP2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009462 284 ANGPT1 http://www.ncbi.nlm.nih.gov/gene/?term=284 "AGP1, AGPT, ANG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009463 285074 LOC285074 http://www.ncbi.nlm.nih.gov/gene/?term=285074 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009464 285095 LOC285095 http://www.ncbi.nlm.nih.gov/gene/?term=285095 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009465 28511 NKIRAS2 http://www.ncbi.nlm.nih.gov/gene/?term=28511 "KBRAS2, kappaB-Ras2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009466 28511 NKIRAS2 http://www.ncbi.nlm.nih.gov/gene/?term=28511 "KBRAS2, kappaB-Ras2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009467 28513 CDH19 http://www.ncbi.nlm.nih.gov/gene/?term=28513 "CDH7, CDH7L2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009468 285148 IAH1 http://www.ncbi.nlm.nih.gov/gene/?term=285148 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009469 28514 DLL1 http://www.ncbi.nlm.nih.gov/gene/?term=28514 "DELTA1, DL1, Delta " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009470 285194 TUSC7 http://www.ncbi.nlm.nih.gov/gene/?term=285194 "LINC00902, LSAMP-AS1, LSAMP-AS3, LSAMPAS3, NCRNA00295 " lncRNA Homo sapiens 23558749 Cytoplasm Colon cancer cell In situ hybridization "Moreover, we performed in situ hybridization to detect the level of loc285194 in the cells after doxo treatment. We observed a substantial increase of loc285194 in the doxo-treated cells compared with no doxo control (Figure 1D). Of note, we found that a majority signal came from the cytoplasm. " RLID00009471 285195 SLC9A9 http://www.ncbi.nlm.nih.gov/gene/?term=285195 "AUTS16, NHE9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009472 285203 EOGT http://www.ncbi.nlm.nih.gov/gene/?term=285203 "AER61, AOS4, C3orf64, EOGT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009473 285203 EOGT http://www.ncbi.nlm.nih.gov/gene/?term=285203 "AER61, AOS4, C3orf641, EOGT " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009474 285203 EOGT http://www.ncbi.nlm.nih.gov/gene/?term=285203 "AER61, AOS4, C3orf641, EOGT " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009475 285268 ZNF621 http://www.ncbi.nlm.nih.gov/gene/?term=285268 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009476 285268 ZNF621 http://www.ncbi.nlm.nih.gov/gene/?term=285268 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009477 285282 RABL3 http://www.ncbi.nlm.nih.gov/gene/?term=285282 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009478 2852 GPER1 http://www.ncbi.nlm.nih.gov/gene/?term=2852 "CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPER, GPR30, LERGU, LERGU2, LyGPR, mER " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009479 2852 GPER1 http://www.ncbi.nlm.nih.gov/gene/?term=2852 "CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPER, GPR30, LERGU, LERGU2, LyGPR, mER " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009480 285315 C3orf33 http://www.ncbi.nlm.nih.gov/gene/?term=285315 AC3-33 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009481 285315 C3orf33 http://www.ncbi.nlm.nih.gov/gene/?term=285315 AC3-33 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009482 285343 TCAIM http://www.ncbi.nlm.nih.gov/gene/?term=285343 "C3orf23, TOAG-1, TOAG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009483 285362 SUMF1 http://www.ncbi.nlm.nih.gov/gene/?term=285362 "AAPA3037, FGE, UNQ3037 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009484 285362 SUMF1 http://www.ncbi.nlm.nih.gov/gene/?term=285362 "AAPA3037, FGE, UNQ3037 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009485 285367 RPUSD3 http://www.ncbi.nlm.nih.gov/gene/?term=285367 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009486 285367 RPUSD3 http://www.ncbi.nlm.nih.gov/gene/?term=285367 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009487 285381 DPH3 http://www.ncbi.nlm.nih.gov/gene/?term=285381 "DELGIP, DELGIP1, DESR1, DPH3A, KTI11, ZCSL2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009488 285381 DPH3 http://www.ncbi.nlm.nih.gov/gene/?term=285381 "DELGIP, DELGIP1, DESR1A, KTI11, ZCSL2, DPH3 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009489 285381 DPH3 http://www.ncbi.nlm.nih.gov/gene/?term=285381 "DELGIP, DELGIP1, DESR1A, KTI11, ZCSL2, DPH3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009490 285382 C3orf70 http://www.ncbi.nlm.nih.gov/gene/?term=285382 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009491 285382 C3orf70 http://www.ncbi.nlm.nih.gov/gene/?term=285382 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009492 285429 DCAF4L1 http://www.ncbi.nlm.nih.gov/gene/?term=285429 WDR21B mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009493 285429 DCAF4L1 http://www.ncbi.nlm.nih.gov/gene/?term=285429 WDR21B mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009494 285440 CYP4V2 http://www.ncbi.nlm.nih.gov/gene/?term=285440 "BCD, CYP4AH1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009495 285440 CYP4V2 http://www.ncbi.nlm.nih.gov/gene/?term=285440 "BCD, CYP4AH1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009496 285513 GPRIN3 http://www.ncbi.nlm.nih.gov/gene/?term=285513 GRIN3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009497 285521 COX18 http://www.ncbi.nlm.nih.gov/gene/?term=285521 COX18HS mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009498 285521 COX18 http://www.ncbi.nlm.nih.gov/gene/?term=285521 COX18HS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009499 285521 COX18 http://www.ncbi.nlm.nih.gov/gene/?term=285521 COX18HS mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009500 285521 COX18 http://www.ncbi.nlm.nih.gov/gene/?term=285521 COX18HS mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009501 285527 FRYL http://www.ncbi.nlm.nih.gov/gene/?term=285527 "AF4p12, KIAA0826, MOR2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009502 285533 RNF175 http://www.ncbi.nlm.nih.gov/gene/?term=285533 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009503 285550 FAM200B http://www.ncbi.nlm.nih.gov/gene/?term=285550 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009504 285550 FAM200B http://www.ncbi.nlm.nih.gov/gene/?term=285550 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009505 285605 DTWD2 http://www.ncbi.nlm.nih.gov/gene/?term=285605 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009506 285605 DTWD2 http://www.ncbi.nlm.nih.gov/gene/?term=285605 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009507 285605 DTWD2 http://www.ncbi.nlm.nih.gov/gene/?term=285605 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009508 285668 C5orf64 http://www.ncbi.nlm.nih.gov/gene/?term=285668 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009509 285668 C5orf64 http://www.ncbi.nlm.nih.gov/gene/?term=285668 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009510 285672 SREK1IP1 http://www.ncbi.nlm.nih.gov/gene/?term=285672 "P18SRP, SFRS12IP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009511 285755 PPIL6 http://www.ncbi.nlm.nih.gov/gene/?term=285755 "PPIase, RSPH12, bA425D10.6, dJ919F19.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009512 285755 PPIL6 http://www.ncbi.nlm.nih.gov/gene/?term=285755 "PPIase, RSPH12, bA425D10.6, dJ919F19.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009513 285761 DCBLD1 http://www.ncbi.nlm.nih.gov/gene/?term=285761 dJ94G16.1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009514 285761 DCBLD1 http://www.ncbi.nlm.nih.gov/gene/?term=285761 dJ94G16.1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009515 285780 LY86-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=285780 "LY86-AS, LY86AS " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009516 285812 LOC285812 http://www.ncbi.nlm.nih.gov/gene/?term=285812 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009517 285835 LOC285835 http://www.ncbi.nlm.nih.gov/gene/?term=285835 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009518 285849 COX6A1P2 http://www.ncbi.nlm.nih.gov/gene/?term=285849 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009519 285855 RPL7L1 http://www.ncbi.nlm.nih.gov/gene/?term=285855 dJ475N16.4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009520 285958 SNHG15 http://www.ncbi.nlm.nih.gov/gene/?term=285958 "C7orf40, Linc-Myo1g, MYO1GUT " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009521 285958 SNHG15 http://www.ncbi.nlm.nih.gov/gene/?term=285958 "C7orf40, Linc-Myo1g, MYO1GUT " lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009522 285961 SEPT7P9 http://www.ncbi.nlm.nih.gov/gene/?term=285961 "CDC10L, SEPT7L, bA291L22.2 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009523 285971 ZNF775 http://www.ncbi.nlm.nih.gov/gene/?term=285971 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009524 285973 ATG9B http://www.ncbi.nlm.nih.gov/gene/?term=285973 "APG9L2, NOS3AS, SONE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009525 2859 GPR35 http://www.ncbi.nlm.nih.gov/gene/?term=2859 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009526 285 ANGPT2 http://www.ncbi.nlm.nih.gov/gene/?term=285 "AGPT2, ANG2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009527 286053 NSMCE2 http://www.ncbi.nlm.nih.gov/gene/?term=286053 "C8orf36, MMS21, NSE2, ZMIZ7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009528 286075 ZNF707 http://www.ncbi.nlm.nih.gov/gene/?term=286075 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009529 286075 ZNF707 http://www.ncbi.nlm.nih.gov/gene/?term=286075 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009530 286077 FAM83H http://www.ncbi.nlm.nih.gov/gene/?term=286077 AI3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009531 286077 FAM83H http://www.ncbi.nlm.nih.gov/gene/?term=286077 AI3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009532 286101 ZNF252P http://www.ncbi.nlm.nih.gov/gene/?term=286101 ZNF252 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009533 286109 CASC7 http://www.ncbi.nlm.nih.gov/gene/?term=286109 LINC00980 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009534 286144 TRIQK http://www.ncbi.nlm.nih.gov/gene/?term=286144 "C8orf83, PRO0845, UPF0599 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009535 286148 DPY19L4 http://www.ncbi.nlm.nih.gov/gene/?term=286148 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009536 286207 CFAP157 http://www.ncbi.nlm.nih.gov/gene/?term=286207 C9orf117 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009537 286223 C9orf47 http://www.ncbi.nlm.nih.gov/gene/?term=286223 "C9orf108, bA791O21.3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009538 286257 C9orf142 http://www.ncbi.nlm.nih.gov/gene/?term=286257 PAXX mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009539 286262 TPRN http://www.ncbi.nlm.nih.gov/gene/?term=286262 "C9orf75, DFNB79 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009540 286262 TPRN http://www.ncbi.nlm.nih.gov/gene/?term=286262 "C9orf75, DFNB79 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009541 286451 YIPF6 http://www.ncbi.nlm.nih.gov/gene/?term=286451 FinGER6 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009542 286451 YIPF6 http://www.ncbi.nlm.nih.gov/gene/?term=286451 FinGER6 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009543 286827 TRIM59 http://www.ncbi.nlm.nih.gov/gene/?term=286827 "IFT80L, MRF1, RNF104, TRIM57, TSBF1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009544 286827 TRIM59 http://www.ncbi.nlm.nih.gov/gene/?term=286827 "IFT80L, MRF1, RNF104, TRIM57, TSBF1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009545 286827 TRIM59 http://www.ncbi.nlm.nih.gov/gene/?term=286827 "IFT80L, MRF1, RNF104, TRIM57, TSBF1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009546 286827 TRIM59 http://www.ncbi.nlm.nih.gov/gene/?term=286827 "IFT80L, MRF1, RNF104, TRIM57, TSBF1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009547 2868 GRK4 http://www.ncbi.nlm.nih.gov/gene/?term=2868 "GPRK2L, GPRK4, GRK4a, IT11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009548 286923 Dlgap3 http://www.ncbi.nlm.nih.gov/gene/?term=286923 "DAP-3, Dap3, SAPAP3 " mRNA Rattus norvegicus 15207911 Dendrite Hippocampus In situ hybridization "Dendritic localization of SAPAP3 transcripts in the hippocampus is observed throughout postnatal development (Fig. 6A, P3-adult). In horizontal sections of P21 rat brain, both SAPAP3(+) and SAPAP3(-) transcripts are localized into dendrites (Fig. 6B). Two mRNAs encoding distinct SAPAP3 isoforms exhibit basically identical postnatal expression patterns and are both localized into dendrites of hippocampal neurons. " RLID00009549 2869 GRK5 http://www.ncbi.nlm.nih.gov/gene/?term=2869 GPRK5 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009550 286 ANK1 http://www.ncbi.nlm.nih.gov/gene/?term=286 "ANK, SPH1, SPH2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009551 287004 LOC287004 http://www.ncbi.nlm.nih.gov/gene/?term=287004 "GB.7, Pinc " lncRNA Rattus norvegicus 16574773 Cytoplasm Mammary gland In situ hybridization|RT-PCR Here we report that PINC expression is temporally and spatially regulated in response to developmental stimuli in vivo and that PINC RNA is localized to distinct foci in either the nucleus or the cytoplasm in a cell-cycle-specific manner. RLID00009552 287004 LOC287004 http://www.ncbi.nlm.nih.gov/gene/?term=287004 "GB.7, Pinc " lncRNA Rattus norvegicus 16574773 Nucleus Mammary gland In situ hybridization|RT-PCR Here we report that PINC expression is temporally and spatially regulated in response to developmental stimuli in vivo and that PINC RNA is localized to distinct foci in either the nucleus or the cytoplasm in a cell-cycle-specific manner. RLID00009553 2870 GRK6 http://www.ncbi.nlm.nih.gov/gene/?term=2870 GPRK6 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009554 2870 GRK6 http://www.ncbi.nlm.nih.gov/gene/?term=2870 GPRK6 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009555 2872 MKNK2 http://www.ncbi.nlm.nih.gov/gene/?term=2872 "GPRK7, MNK2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009556 2872 MKNK2 http://www.ncbi.nlm.nih.gov/gene/?term=2872 "GPRK7, MNK2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009557 28738 TRAJ17 http://www.ncbi.nlm.nih.gov/gene/?term=28738 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009558 2873 GPS1 http://www.ncbi.nlm.nih.gov/gene/?term=2873 "COPS1, CSN1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009559 2873 GPS1 http://www.ncbi.nlm.nih.gov/gene/?term=2873 "COPS1, CSN1, SGN1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009560 2873 GPS1 http://www.ncbi.nlm.nih.gov/gene/?term=2873 "COPS1, CSN1, SGN1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009561 2875 GPT http://www.ncbi.nlm.nih.gov/gene/?term=2875 "AAT1, ALT1, GPT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009562 2876 GPX1 http://www.ncbi.nlm.nih.gov/gene/?term=2876 "GPXD, GSHPX1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009563 2876 GPX1 http://www.ncbi.nlm.nih.gov/gene/?term=2876 "GPXD, GSHPX1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009564 2876 GPX1 http://www.ncbi.nlm.nih.gov/gene/?term=2876 "GPXD, GSHPX1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009565 2877 GPX2 http://www.ncbi.nlm.nih.gov/gene/?term=2877 "GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPX-GI, GSHPx-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009566 2877 GPX2 http://www.ncbi.nlm.nih.gov/gene/?term=2877 "GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPX-GI, GSHPx-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009567 2878 GPX3 http://www.ncbi.nlm.nih.gov/gene/?term=2878 "GPx-P, GSHPx-3, GSHPx-P " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009568 2879 GPX4 http://www.ncbi.nlm.nih.gov/gene/?term=2879 "GPx-4, GSHPx-4, MCSP, PHGPx, SMDS, snGPx, snPHGPx " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009569 2879 GPX4 http://www.ncbi.nlm.nih.gov/gene/?term=2879 "GPx-4, GSHPx-4, MCSP, PHGPx, SMDS, snGPx, snPHGPx " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009570 2879 GPX4 http://www.ncbi.nlm.nih.gov/gene/?term=2879 "GPx-4, GSHPx-4, MCSP, PHGPx, SMDS, snGPx, snPHGPx " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009571 287 ANK2 http://www.ncbi.nlm.nih.gov/gene/?term=287 "ANK-2, LQT4, brank-2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009572 288064 Kpna1 http://www.ncbi.nlm.nih.gov/gene/?term=288064 mRNA Rattus norvegicus 26180210 Axon Spinal cord In situ hybridization "By quantitative fluorescent in situ hybridization combined with immunofluorescence to unambiguously distinguish intra-axonal mRNAs, we show that regenerating spinal cord axons contain β-actin, GAP-43, Neuritin, Reg3a, Hamp, and Importin β1 mRNAs. " RLID00009573 288064 Kpna1 http://www.ncbi.nlm.nih.gov/gene/?term=288064 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00009574 2885 GRB2 http://www.ncbi.nlm.nih.gov/gene/?term=2885 "ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009575 2885 GRB2 http://www.ncbi.nlm.nih.gov/gene/?term=2885 "ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009576 2886 GRB7 http://www.ncbi.nlm.nih.gov/gene/?term=2886 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009577 2887 GRB10 http://www.ncbi.nlm.nih.gov/gene/?term=2887 "GRB-IR, Grb-10, IRBP, MEG1, RSS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009578 2887 GRB10 http://www.ncbi.nlm.nih.gov/gene/?term=2887 "GRB-IR, Grb-10, IRBP, MEG1, RSS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009579 2887 GRB10 http://www.ncbi.nlm.nih.gov/gene/?term=2887 "GRB-IR, Grb-10, IRBP, MEG1, RSS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009580 288 ANK3 http://www.ncbi.nlm.nih.gov/gene/?term=288 "ANKYRIN-G, MRT37 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009581 28951 TRIB2 http://www.ncbi.nlm.nih.gov/gene/?term=28951 "C5FW, GS3955, TRB2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009582 28951 TRIB2 http://www.ncbi.nlm.nih.gov/gene/?term=28951 "C5FW, GS3955, TRB2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009583 28952 CCDC22 http://www.ncbi.nlm.nih.gov/gene/?term=28952 "CXorf37, JM1, RTSC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009584 28955 DEXI http://www.ncbi.nlm.nih.gov/gene/?term=28955 MYLE mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009585 28955 DEXI http://www.ncbi.nlm.nih.gov/gene/?term=28955 MYLE mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009586 28956 LAMTOR2 http://www.ncbi.nlm.nih.gov/gene/?term=28956 "ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, ROBLD3, Ragulator2, p14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009587 28957 MRPS28 http://www.ncbi.nlm.nih.gov/gene/?term=28957 "HSPC007, MRP-S28, MRP-S35, MRPS35 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009588 28957 MRPS28 http://www.ncbi.nlm.nih.gov/gene/?term=28957 "HSPC007, MRP-S28, MRP-S35, MRPS35 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009589 28958 COA3 http://www.ncbi.nlm.nih.gov/gene/?term=28958 "CCDC56, HSPC009, MITRAC12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009590 28960 DCPS http://www.ncbi.nlm.nih.gov/gene/?term=28960 "ARS, DCS1, HINT-5, HINT5, HSL1, HSPC015 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009591 28962 OSTM1 http://www.ncbi.nlm.nih.gov/gene/?term=28962 "GIPN, GL, HSPC019, OPTB5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009592 28962 OSTM1 http://www.ncbi.nlm.nih.gov/gene/?term=28962 "GIPN, GL, HSPC019, OPTB5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009593 28965 SLC27A6 http://www.ncbi.nlm.nih.gov/gene/?term=28965 "ACSVL2, FACVL2, FATP6, VLCS-H1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009594 28966 SNX24 http://www.ncbi.nlm.nih.gov/gene/?term=28966 "PRO1284, SBBI31 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009595 28969 BZW2 http://www.ncbi.nlm.nih.gov/gene/?term=28969 "HSPC028, MST017, MSTP017 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009596 2896 GRN http://www.ncbi.nlm.nih.gov/gene/?term=2896 "CLN11, GEP, GP88, PCDGF, PEPI, PGRN " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009597 2896 GRN http://www.ncbi.nlm.nih.gov/gene/?term=2896 "CLN11, GEP, GP88, PCDGF, PEPI, PGRN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009598 2896 GRN http://www.ncbi.nlm.nih.gov/gene/?term=2896 "CLN11, GEP, GP88, PCDGF, PEPI, PGRN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009599 28970 C11orf54 http://www.ncbi.nlm.nih.gov/gene/?term=28970 "PTD012, PTOD012 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009600 28971 AAMDC http://www.ncbi.nlm.nih.gov/gene/?term=28971 "C11orf67, CK067, PTD015 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009601 28972 SPCS1 http://www.ncbi.nlm.nih.gov/gene/?term=28972 "HSPC033, SPC1, SPC12, YJR010C-A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009602 28973 MRPS18B http://www.ncbi.nlm.nih.gov/gene/?term=28973 "C6orf14, HSPC183, HumanS18a, MRP-S18-2, MRPS18-2, PTD017, S18amt " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009603 28973 MRPS18B http://www.ncbi.nlm.nih.gov/gene/?term=28973 "C6orf14, HSPC183, HumanS18a, MRP-S18-2, MRPS18-2, PTD017, S18amt " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009604 28974 C19orf53 http://www.ncbi.nlm.nih.gov/gene/?term=28974 "HSPC023, LYDG10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009605 28974 C19orf53 http://www.ncbi.nlm.nih.gov/gene/?term=28974 "HSPC023, LYDG10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009606 28976 ACAD9 http://www.ncbi.nlm.nih.gov/gene/?term=28976 NPD002 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009607 28976 ACAD9 http://www.ncbi.nlm.nih.gov/gene/?term=28976 NPD002 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009608 28977 MRPL42 http://www.ncbi.nlm.nih.gov/gene/?term=28977 "HSPC204, L31MT, L42MT, MRP-L31, MRP-L42, MRP-S32, MRPL31, MRPS32, PTD007, RPML31, S32MT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009609 28978 TMEM14A http://www.ncbi.nlm.nih.gov/gene/?term=28978 "C6orf73, PTD011 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009610 28981 IFT81 http://www.ncbi.nlm.nih.gov/gene/?term=28981 "CDV-1, CDV-1R, CDV1, CDV1R, DV1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009611 28982 FLVCR1 http://www.ncbi.nlm.nih.gov/gene/?term=28982 "AXPC1, FLVCR, MFSD7B, PCA, PCARP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009612 28985 MCTS1 http://www.ncbi.nlm.nih.gov/gene/?term=28985 "MCT-1, MCT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009613 28985 MCTS1 http://www.ncbi.nlm.nih.gov/gene/?term=28985 "MCT-1, MCT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009614 28985 MCTS1 http://www.ncbi.nlm.nih.gov/gene/?term=28985 "MCT-1, MCT1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009615 28987 NOB1 http://www.ncbi.nlm.nih.gov/gene/?term=28987 "ART-4, MST158, MSTP158P, PSMD8BP1, NOB1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009616 28988 DBNL http://www.ncbi.nlm.nih.gov/gene/?term=28988 "ABP1, HIP-55, HIP55, SH3P7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009617 28989 NTMT1 http://www.ncbi.nlm.nih.gov/gene/?term=28989 "AD-003, C9orf32, HOMT1A, METTL11A, NRMT, NTM1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009618 28991 COMMD5 http://www.ncbi.nlm.nih.gov/gene/?term=28991 "HCARG, HT002 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009619 28991 COMMD5 http://www.ncbi.nlm.nih.gov/gene/?term=28991 "HCARG, HT002 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009620 28992 MACROD1 http://www.ncbi.nlm.nih.gov/gene/?term=28992 LRP16 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009621 28992 MACROD1 http://www.ncbi.nlm.nih.gov/gene/?term=28992 LRP16 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009622 28996 HIPK2 http://www.ncbi.nlm.nih.gov/gene/?term=28996 PRO0593 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009623 28996 HIPK2 http://www.ncbi.nlm.nih.gov/gene/?term=28996 PRO0593 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009624 28996 HIPK2 http://www.ncbi.nlm.nih.gov/gene/?term=28996 PRO0593 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009625 28998 MRPL13 http://www.ncbi.nlm.nih.gov/gene/?term=28998 "L13, L13A, L13mt, RPL13, RPML13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009626 2899 GRIK3 http://www.ncbi.nlm.nih.gov/gene/?term=2899 "EAA5, GLR7, GLUR7, GluK3, GluR7a " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009627 29015 SLC43A3 http://www.ncbi.nlm.nih.gov/gene/?term=29015 "EEG1, FOAP-13, PRO1659, SEEEG-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009628 29028 ATAD2 http://www.ncbi.nlm.nih.gov/gene/?term=29028 "ANCCA, CT137, PRO2000 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009629 29028 ATAD2 http://www.ncbi.nlm.nih.gov/gene/?term=29028 "ANCCA, CT137, PRO2000 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009630 29035 C16orf72 http://www.ncbi.nlm.nih.gov/gene/?term=29035 PRO0149 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009631 29035 C16orf72 http://www.ncbi.nlm.nih.gov/gene/?term=29035 PRO0149 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009632 2903 GRIN2A http://www.ncbi.nlm.nih.gov/gene/?term=2903 "EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009633 29058 TMEM230 http://www.ncbi.nlm.nih.gov/gene/?term=29058 "C20orf30, HSPC274, dJ1116H23.2.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009634 29058 TMEM230 http://www.ncbi.nlm.nih.gov/gene/?term=29058 "C20orf30, HSPC274, dJ1116H23.2.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009635 2905 GRIN2C http://www.ncbi.nlm.nih.gov/gene/?term=2905 "GluN2C, NMDAR2C, NR2C " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009636 29066 ZC3H7A http://www.ncbi.nlm.nih.gov/gene/?term=29066 "HSPC055, ZC3H7, ZC3HDC7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009637 29068 ZBTB44 http://www.ncbi.nlm.nih.gov/gene/?term=29068 "BTBD15, HSPC063, ZNF851 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009638 29070 CCDC113 http://www.ncbi.nlm.nih.gov/gene/?term=29070 HSPC065 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009639 29070 CCDC113 http://www.ncbi.nlm.nih.gov/gene/?term=29070 HSPC065 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009640 29072 SETD2 http://www.ncbi.nlm.nih.gov/gene/?term=29072 "HBP231, HIF-1, HIP-1, HSPC069, HYPB, KMT3A, SET2, p231HBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009641 29072 SETD2 http://www.ncbi.nlm.nih.gov/gene/?term=29072 "HBP231, HIF-1, HIP-1, HSPC069, HYPB, KMT3A, LLS, SET2, p231HBP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009642 29072 SETD2 http://www.ncbi.nlm.nih.gov/gene/?term=29072 "HBP231, HIF-1, HIP-1, HSPC069, HYPB, KMT3A, LLS, SET2, p231HBP " mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00009643 29074 MRPL18 http://www.ncbi.nlm.nih.gov/gene/?term=29074 "HSPC071, L18mt, MRP-L18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009644 29074 MRPL18 http://www.ncbi.nlm.nih.gov/gene/?term=29074 "HSPC071, L18mt, MRP-L18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009645 29078 NDUFAF4 http://www.ncbi.nlm.nih.gov/gene/?term=29078 "C6orf66, HRPAP20, HSPC125, My013, bA22L21.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009646 29078 NDUFAF4 http://www.ncbi.nlm.nih.gov/gene/?term=29078 "C6orf66, HRPAP20, HSPC125, My013, bA22L21.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009647 29079 MED4 http://www.ncbi.nlm.nih.gov/gene/?term=29079 "ARC36, DRIP36, HSPC126, TRAP36, VDRIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009648 29079 MED4 http://www.ncbi.nlm.nih.gov/gene/?term=29079 "ARC36, DRIP36, HSPC126, TRAP36, VDRIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009649 29079 MED4 http://www.ncbi.nlm.nih.gov/gene/?term=29079 "ARC36, DRIP36, HSPC126, TRAP36, VDRIP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009650 2907 GRINA http://www.ncbi.nlm.nih.gov/gene/?term=2907 "HNRGW, LFG1, NMDARA1, TMBIM3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009651 2907 GRINA http://www.ncbi.nlm.nih.gov/gene/?term=2907 "HNRGW, LFG1, NMDARA1, TMBIM3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009652 29080 CCDC59 http://www.ncbi.nlm.nih.gov/gene/?term=29080 "BR22, HSPC128, TAP26 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009653 29080 CCDC59 http://www.ncbi.nlm.nih.gov/gene/?term=29080 "BR22, HSPC128, TAP26 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009654 29081 METTL5 http://www.ncbi.nlm.nih.gov/gene/?term=29081 HSPC133 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009655 29083 GTPBP8 http://www.ncbi.nlm.nih.gov/gene/?term=29083 HSPC135 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009656 29085 PHPT1 http://www.ncbi.nlm.nih.gov/gene/?term=29085 "CGI-202, HEL-S-132P, HSPC141, PHP14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009657 29086 BABAM1 http://www.ncbi.nlm.nih.gov/gene/?term=29086 "C19orf62, HSPC142, MERIT40, NBA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009658 29087 THYN1 http://www.ncbi.nlm.nih.gov/gene/?term=29087 "HSPC144, MDS012, MY105, THY28, THY28KD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009659 29087 THYN1 http://www.ncbi.nlm.nih.gov/gene/?term=29087 "HSPC144, MDS012, MY105, THY28, THY28KD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009660 29088 MRPL15 http://www.ncbi.nlm.nih.gov/gene/?term=29088 "HSPC145, L15mt, MRP-L15, MRP-L7, RPML7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009661 29088 MRPL15 http://www.ncbi.nlm.nih.gov/gene/?term=29088 "HSPC145, L15mt, MRP-L15, MRP-L7, RPML7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009662 29089 UBE2T http://www.ncbi.nlm.nih.gov/gene/?term=29089 "FANCT, HSPC150, PIG50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009663 29089 UBE2T http://www.ncbi.nlm.nih.gov/gene/?term=29089 "FANCT, HSPC150, PIG50 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009664 29089 UBE2T http://www.ncbi.nlm.nih.gov/gene/?term=29089 "FANCT, HSPC150, PIG50 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009665 2908 NR3C1 http://www.ncbi.nlm.nih.gov/gene/?term=2908 "GCCR, GCR, GCRST, GR, GRL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009666 29090 TIMM21 http://www.ncbi.nlm.nih.gov/gene/?term=29090 "C18orf55, HSPC154, TIM21 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009667 29090 TIMM21 http://www.ncbi.nlm.nih.gov/gene/?term=29090 "C18orf55, HSPC154, TIM21 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009668 29090 TIMM21 http://www.ncbi.nlm.nih.gov/gene/?term=29090 "C18orf55, HSPC154, TIM21 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009669 29090 TIMM21 http://www.ncbi.nlm.nih.gov/gene/?term=29090 "C18orf55, HSPC154, TIM21 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009670 29092 LINC00339 http://www.ncbi.nlm.nih.gov/gene/?term=29092 "HSPC157, NCRNA00339 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009671 29092 LINC00339 http://www.ncbi.nlm.nih.gov/gene/?term=29092 "HSPC157, NCRNA00339 " lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009672 29093 MRPL22 http://www.ncbi.nlm.nih.gov/gene/?term=29093 "HSPC158, L22mt, MRP-L22, MRP-L25, RPML25 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009673 29094 LGALSL http://www.ncbi.nlm.nih.gov/gene/?term=29094 "GRP, HSPC159 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009674 29095 ORMDL2 http://www.ncbi.nlm.nih.gov/gene/?term=29095 "HSPC160, MST095, MSTP095, adoplin-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009675 29097 CNIH4 http://www.ncbi.nlm.nih.gov/gene/?term=29097 "CNIH-4, HSPC163 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009676 29097 CNIH4 http://www.ncbi.nlm.nih.gov/gene/?term=29097 "CNIH-4, HSPC163 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009677 29098 RANGRF http://www.ncbi.nlm.nih.gov/gene/?term=29098 "HSPC165, HSPC236, MOG1, RANGNRF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009678 29099 COMMD9 http://www.ncbi.nlm.nih.gov/gene/?term=29099 HSPC166 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009679 29099 COMMD9 http://www.ncbi.nlm.nih.gov/gene/?term=29099 HSPC166 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009680 29099 COMMD9 http://www.ncbi.nlm.nih.gov/gene/?term=29099 HSPC166 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009681 2909 ARHGAP35 http://www.ncbi.nlm.nih.gov/gene/?term=2909 "GRF-1, GRLF1, P190-A, P190A, p190ARhoGAP, p190RhoGAP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009682 29100 TMEM208 http://www.ncbi.nlm.nih.gov/gene/?term=29100 HSPC171 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009683 29101 SSU72 http://www.ncbi.nlm.nih.gov/gene/?term=29101 "HSPC182, PNAS-120 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009684 29102 DROSHA http://www.ncbi.nlm.nih.gov/gene/?term=29102 "ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009685 29103 DNAJC15 http://www.ncbi.nlm.nih.gov/gene/?term=29103 "DNAJD1, HSD18, MCJ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009686 29105 CFAP20 http://www.ncbi.nlm.nih.gov/gene/?term=29105 "C16orf80, EVORF, GTL3, fSAP23 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009687 29105 CFAP20 http://www.ncbi.nlm.nih.gov/gene/?term=29105 "C16orf80, EVORF, GTL3, fSAP23 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009688 29107 NXT1 http://www.ncbi.nlm.nih.gov/gene/?term=29107 "MTR2, P15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009689 29108 PYCARD http://www.ncbi.nlm.nih.gov/gene/?term=29108 "ASC, CARD5, TMS, TMS-1, TMS1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009690 29109 FHOD1 http://www.ncbi.nlm.nih.gov/gene/?term=29109 FHOS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009691 29114 TAGLN3 http://www.ncbi.nlm.nih.gov/gene/?term=29114 "NP22, NP24, NP25 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009692 29115 SAP30BP http://www.ncbi.nlm.nih.gov/gene/?term=29115 "HCNGP, HTRG, HTRP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009693 29115 SAP30BP http://www.ncbi.nlm.nih.gov/gene/?term=29115 "HCNGP, HTRG, HTRP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009694 29116 MYLIP http://www.ncbi.nlm.nih.gov/gene/?term=29116 "IDOL, MIR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009695 29116 MYLIP http://www.ncbi.nlm.nih.gov/gene/?term=29116 "IDOL, MIR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009696 29117 BRD7 http://www.ncbi.nlm.nih.gov/gene/?term=29117 "BP75, CELTIX1, NAG4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009697 29117 BRD7 http://www.ncbi.nlm.nih.gov/gene/?term=29117 "BP75, CELTIX1, NAG4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009698 29123 ANKRD11 http://www.ncbi.nlm.nih.gov/gene/?term=29123 "ANCO-1, ANCO1, LZ16, T13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009699 29123 ANKRD11 http://www.ncbi.nlm.nih.gov/gene/?term=29123 "ANCO-1, ANCO1, LZ16, T13 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009700 29127 RACGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=29127 "CYK4, HsCYK-4, ID-GAP, MgcRacGAP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009701 2912 GRM2 http://www.ncbi.nlm.nih.gov/gene/?term=2912 "GLUR2, GPRC1B, MGLUR2, mGlu2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009702 291339 Commd3 http://www.ncbi.nlm.nih.gov/gene/?term=291339 mRNA Rattus norvegicus 25301173 Dendrite Hippocampus In situ hybridization "Figure 2: In situ hybridization reveals species-specific patterns of localization in neuronal dendrites. Fluorescent Microscopy evaluation of biotin-conjugated oligoprobes on paraformaldehyde fixed 14-day cultured rat and mouse cortical neurons hybridized with nine biotin-conjugated oligoprobes detected with streptadivin-Alexa Fluor 568 (Invitrogen). For each probe images set, the small bottom left corner panels represent MAP2 immuno-staining. Scale bar = 20um. (A), Probes against SFRS16, ARHGDIA and HNRPK transcripts show higher dendritic localization in mouse neurons than in rat neurons (Red box). (B), Probes against ZFP410, COMMD3 and RSP6 transcripts show higher dendritic localization in rat neurons than in mouse neurons (Blue box). (C), Probes against UBA52, OLFM1 and H2AFZ transcripts show high dendritic localization in both rat and mouse neurons (Black box). Data are collected from Figure 2. " RLID00009703 2913 GRM3 http://www.ncbi.nlm.nih.gov/gene/?term=2913 "GLUR3, GPRC1C, MGLUR3, mGlu3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009704 29141 Gal http://www.ncbi.nlm.nih.gov/gene/?term=29141 Galn mRNA Rattus norvegicus 9579792 Dendrite Neuron In situ hybridization Preprogalanin messenger RNA was also clustered in dendrites containing rough endoplasmic reticulum. RLID00009705 29141 Gal http://www.ncbi.nlm.nih.gov/gene/?term=29141 Galn mRNA Rattus norvegicus 9579792 Axon Neuron In situ hybridization "In the present study, using non-radioactive in situ hybridization and immunohistochemistry at the light and electron microscope levels, preprogalanin messenger RNA and galanin-like immunoreactivity were localized in the hypothalamo-posthypophyseal system. After salt loading, preprogalanin transcripts were found throughout the perikaryal cytoplasm, especially in the peripheral cytoplasm and in the perinuclear area. Preprogalanin messenger RNA was also clustered in dendrites containing rough endoplasmic reticulum. Thus, preprogalanin messenger RNA was segregated in the axons. " RLID00009706 29141 Gal http://www.ncbi.nlm.nih.gov/gene/?term=29141 Galn mRNA Rattus norvegicus 9579792 Cytoplasm Neuron In situ hybridization "In the present study, using non-radioactive in situ hybridization and immunohistochemistry at the light and electron microscope levels, preprogalanin messenger RNA and galanin-like immunoreactivity were localized in the hypothalamo-posthypophyseal system. After salt loading, preprogalanin transcripts were found throughout the perikaryal cytoplasm, especially in the peripheral cytoplasm and in the perinuclear area. Preprogalanin messenger RNA was also clustered in dendrites containing rough endoplasmic reticulum. Thus, preprogalanin messenger RNA was segregated in the axons. " RLID00009707 29141 Gal http://www.ncbi.nlm.nih.gov/gene/?term=29141 Galn mRNA Rattus norvegicus 12814355 Cytoplasm Neuron In situ hybridization "Furthermore, galanin and vasopressin messenger RNAs were detected at different domains of the endoplasmic reticulum, suggesting that translation might also occur at different locations, thus leading to partial segregation of galanin and vasopressin cargoes between two populations of secretory granules. In contrast, galanin mRNA was detected in a perinuclear area and in patches scattered in peripheral cytoplasm. In processes, vasopressin mRNA signal was clearly detected(Fig.1B) but labelling remained weak for galanin mRNA. " RLID00009708 29141 Gal http://www.ncbi.nlm.nih.gov/gene/?term=29141 Galn mRNA Rattus norvegicus 12814355 Endoplasmic reticulum Neuron In situ hybridization "Furthermore, galanin and vasopressin messenger RNAs were detected at different domains of the endoplasmic reticulum, suggesting that translation might also occur at different locations, thus leading to partial segregation of galanin and vasopressin cargoes between two populations of secretory granules. In contrast, galanin mRNA was detected in a perinuclear area and in patches scattered in peripheral cytoplasm. In processes, vasopressin mRNA signal was clearly detected(Fig.1B) but labelling remained weak for galanin mRNA. " RLID00009709 2915 GRM5 http://www.ncbi.nlm.nih.gov/gene/?term=2915 "GPRC1E, MGLUR5, PPP1R86, mGlu5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009710 291671 Hspa9 http://www.ncbi.nlm.nih.gov/gene/?term=291671 "Crp40, GRP-75a, PBP74, Hspa9 " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00009711 291671 Hspa9 http://www.ncbi.nlm.nih.gov/gene/?term=291671 "Crp40, GRP-75a, PBP74, Hspa9 " mRNA Rattus norvegicus 15673657 Cell body Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00009712 2916 GRM6 http://www.ncbi.nlm.nih.gov/gene/?term=2916 "CSNB1B, GPRC1F, MGLUR6, mGlu6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009713 2916 GRM6 http://www.ncbi.nlm.nih.gov/gene/?term=2916 "CSNB1B, GPRC1F, MGLUR6, mGlu6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009714 2919 CXCL1 http://www.ncbi.nlm.nih.gov/gene/?term=2919 "FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009715 291 SLC25A4 http://www.ncbi.nlm.nih.gov/gene/?term=291 "AAC1, ANT, ANT 1, ANT1, MTDPS12, PEO2, PEO3, PEOA2, T1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009716 291 SLC25A4 http://www.ncbi.nlm.nih.gov/gene/?term=291 "AAC1, ANT, ANT 1, ANT1, MTDPS12, PEO2, PEO3, PEOA2, T1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009717 291 SLC25A4 http://www.ncbi.nlm.nih.gov/gene/?term=291 "AAC1, ANT, ANT 1, ANT1, MTDPS12, PEO2, PEO3, PEOA2, T1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009718 2920 CXCL2 http://www.ncbi.nlm.nih.gov/gene/?term=2920 "CINC-2a, GRO2, GROb, MGSA-b, MIP-2a, MIP2, MIP2A, SCYB2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009719 29219 Snca http://www.ncbi.nlm.nih.gov/gene/?term=29219 mRNA Rattus norvegicus 25896939 Synapse Nerve cell qRT-PCR|Immunocytochemistry "Physiologically, a-syn is located at the presynapse and might be involved in regulating of neurotransmission. " RLID00009720 2923 PDIA3 http://www.ncbi.nlm.nih.gov/gene/?term=2923 "ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HEL-S-269, HEL-S-93n, HsT17083, P58, PI-PLC " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009721 2923 PDIA3 http://www.ncbi.nlm.nih.gov/gene/?term=2923 "ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HEL-S-269, HEL-S-93n, HsT17083, P58, PI-PLC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009722 2926 GRSF1 http://www.ncbi.nlm.nih.gov/gene/?term=2926 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009723 2926 GRSF1 http://www.ncbi.nlm.nih.gov/gene/?term=2926 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009724 2926 GRSF1 http://www.ncbi.nlm.nih.gov/gene/?term=2926 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009725 29271 Cfl1 http://www.ncbi.nlm.nih.gov/gene/?term=29271 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00009726 29271 Cfl1 http://www.ncbi.nlm.nih.gov/gene/?term=29271 mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00009727 29286 Rps17 http://www.ncbi.nlm.nih.gov/gene/?term=29286 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00009728 29292 Ftl1 http://www.ncbi.nlm.nih.gov/gene/?term=29292 Ftl mRNA Rattus norvegicus 9888989 Cell body Hippocampus In situ hybridization "Using nonisotopic in situ hybridization, ferritin mRNA is found restricted to the cell body of cultured rat hippocampal neurons. " RLID00009729 29294 Bc1 http://www.ncbi.nlm.nih.gov/gene/?term=29294 lncRNA Rattus norvegicus 7692010 Axon Neuron In situ hybridization "In this report, we identify BC1 RNA, a small RNA polymerase III transcript that is specifically expressed in neurons, in hypothalamo-neurohypophyseal axons. Here we present evidence that BC1 RNA is transported along the hypothalamo-neurohypopjyscal tract to axonal nervel endings in the posterior pituitary. While these data indicate that hypothalamo-neurohypophyscal axons contain BC1 RNA, they do not rule out possibility that other, non- neuronal elements in the neurohypophysis may also contrabute to the labeling signal. " RLID00009730 29294 Bc1 http://www.ncbi.nlm.nih.gov/gene/?term=29294 lncRNA Rattus norvegicus 21807882 Dendrite Sympathetic neuron In situ hybridization "We first performed in situ hybridization experiments to confirm that endogenous BC1 RNA is located to somato-dendritic domains of sympathetic neurons in culture (Fig. 4, A and B), which is analogous to the previously reported localization in hippocampal neurons in culture (Muslimov et al., 1998). " RLID00009731 29294 Bc1 http://www.ncbi.nlm.nih.gov/gene/?term=29294 lncRNA Rattus norvegicus 1706516 Dendrite Spinal cord neuron In situ hybridization "In adult rats as well as in immature rats in late developmental stages, BC1 RNA has been located in the dendrites and somata of a subset of neurons in the central and peripheral nervous system. " RLID00009732 29294 Bc1 http://www.ncbi.nlm.nih.gov/gene/?term=29294 lncRNA Rattus norvegicus 9169532 Dendrite Neuron Microinjection "After cytoplasmic microinjection, full-length BC1 RNA was selectively transported to dendrites; in contrast, control RNAs such as nuclear RNAs and random-sequence irrelevant RNAs remained restricted to cytoplasmic areas proximal to the injection sites. We report here that BC1 RNA is selectively transported to dendrites, and that it is competent to direct dendritic targeting of normally nondendritic mRNAs. In summary, the data show that BC1 RNA is transported selectively and specifically to dendrites of sympathetic neurons in culture. " RLID00009733 292 SLC25A5 http://www.ncbi.nlm.nih.gov/gene/?term=292 "2F1, AAC2, ANT2, T2, T3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009734 292 SLC25A5 http://www.ncbi.nlm.nih.gov/gene/?term=292 "2F1, AAC2, ANT2, T2, T3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009735 292 SLC25A5 http://www.ncbi.nlm.nih.gov/gene/?term=292 "2F1, AAC2, ANT2, T2, T3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009736 2931 GSK3A http://www.ncbi.nlm.nih.gov/gene/?term=2931 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009737 2932 GSK3B http://www.ncbi.nlm.nih.gov/gene/?term=2932 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009738 2932 GSK3B http://www.ncbi.nlm.nih.gov/gene/?term=2932 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009739 29335 Oprk1 http://www.ncbi.nlm.nih.gov/gene/?term=29335 mRNA Rattus norvegicus 17167054 Axon Dorsal root ganglia In situ hybridization In situ hybridization detected axonal distribution of kor mRNA in primary neurons of dorsal root ganglia (DRG). RLID00009740 2934 GSN http://www.ncbi.nlm.nih.gov/gene/?term=2934 "ADF, AGEL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009741 2934 GSN http://www.ncbi.nlm.nih.gov/gene/?term=2934 "ADF, AGEL " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009742 2934 GSN http://www.ncbi.nlm.nih.gov/gene/?term=2934 "ADF, AGEL " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009743 2935 GSPT1 http://www.ncbi.nlm.nih.gov/gene/?term=2935 "551G9.2, ETF3A, GST1, eRF3a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009744 2935 GSPT1 http://www.ncbi.nlm.nih.gov/gene/?term=2935 "551G9.2, ETF3A, GST1, eRF3a " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009745 2936 GSR http://www.ncbi.nlm.nih.gov/gene/?term=2936 "HEL-75, HEL-S-122m " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009746 2936 GSR http://www.ncbi.nlm.nih.gov/gene/?term=2936 "HEL-75, HEL-S-122m " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009747 2936 GSR http://www.ncbi.nlm.nih.gov/gene/?term=2936 "HEL-75, HEL-S-122m " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009748 2937 GSS http://www.ncbi.nlm.nih.gov/gene/?term=2937 "GSHS, HEL-S-64p, HEL-S-88n " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009749 2937 GSS http://www.ncbi.nlm.nih.gov/gene/?term=2937 "GSHS, HEL-S-64p, HEL-S-88n " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009750 2938 GSTA1 http://www.ncbi.nlm.nih.gov/gene/?term=2938 "GST2, GTH1, GSTA1-1, GST-epsilon " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00009751 2938 GSTA1 http://www.ncbi.nlm.nih.gov/gene/?term=2938 "GST-epsilon, GST2-1, GTH1, GSTA1 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00009752 293 SLC25A6 http://www.ncbi.nlm.nih.gov/gene/?term=293 "AAC3, ANT, ANT 2, ANT 3, ANT3, ANT3Y " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009753 293 SLC25A6 http://www.ncbi.nlm.nih.gov/gene/?term=293 "AAC3, ANT, ANT 2, ANT 3, ANT3, ANT3Y " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009754 293 SLC25A6 http://www.ncbi.nlm.nih.gov/gene/?term=293 "AAC3, ANT, ANT 2, ANT 3, ANT3, ANT3Y " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009755 293 SLC25A6 http://www.ncbi.nlm.nih.gov/gene/?term=293 "AAC3, ANT, ANT 2, ANT 3, ANT3, ANT3Y " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009756 294239 Ddah2 http://www.ncbi.nlm.nih.gov/gene/?term=294239 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00009757 29423 Gap43 http://www.ncbi.nlm.nih.gov/gene/?term=29423 Basp2 mRNA Rattus norvegicus 2148487 Cell body Neuron In situ hybridization "In contrast, mRNAs encoding GAP-43 and alpha-tubulin were restricted to the cell body and largely excluded from dendrites as well as axons. " RLID00009758 29423 Gap43 http://www.ncbi.nlm.nih.gov/gene/?term=29423 Basp2 mRNA Rattus norvegicus 7773006 Dendrite Neuron In situ hybridization "Table 1. As of 1994, mRNAs that have been localized within dendrites by in situ hybridization. Data are collected from Table 1. " RLID00009759 29423 Gap43 http://www.ncbi.nlm.nih.gov/gene/?term=29423 Basp2 mRNA Rattus norvegicus 7877439 Dendrite Neuron In situ hybridization "Similarly, although stain corresponding to GAP-43 mRNA was found primarily within the soma of pyramidal neurons of hippocampus, it was also evident within the proximal regions of some apical dendrites (arrowheads in Fig. 1D). " RLID00009760 29423 Gap43 http://www.ncbi.nlm.nih.gov/gene/?term=29423 Basp2 mRNA Rattus norvegicus 9322162 Dendrite Cerebral cortex In situ hybridization "The mRNAs for b-tubulin, neurofilament 68, and F1/GAP43 were restricted to the region of the cell body and very proximal dendrites in most neurons. In the cerebral cortex, labeling for F1/GAP43 mRNA extended into the dendrites of large pyramidal neurons, but the distribution was limited to proximal dendritic segments and appeared comparable to the distribution of labeling for NF-68 and b-tubulin mRNAs. " RLID00009761 29423 Gap43 http://www.ncbi.nlm.nih.gov/gene/?term=29423 Basp2 mRNA Rattus norvegicus 9322162 Cell body Cerebral cortex In situ hybridization "The mRNAs for b-tubulin, neurofilament 68, and F1/GAP43 were restricted to the region of the cell body and very proximal dendrites in most neurons. In the cerebral cortex, labeling for F1/GAP43 mRNA extended into the dendrites of large pyramidal neurons, but the distribution was limited to proximal dendritic segments and appeared comparable to the distribution of labeling for NF-68 and b-tubulin mRNAs. " RLID00009762 29423 Gap43 http://www.ncbi.nlm.nih.gov/gene/?term=29423 Basp2 mRNA Rattus norvegicus 23586486 Axon Sciatic nerve Fluorescence in situ hybridization "The cell bodies of these cultured DRG neurons showed a more robust signal for GAP-43 mRNA (Fig. 1A), suggesting that only a fraction of the GAP-43 mRNA localizes into the axonal compartment as previously shown for β-actin mRNA. " RLID00009763 29423 Gap43 http://www.ncbi.nlm.nih.gov/gene/?term=29423 Basp2 mRNA Rattus norvegicus 26180210 Axon Spinal cord In situ hybridization "By quantitative fluorescent in situ hybridization combined with immunofluorescence to unambiguously distinguish intra-axonal mRNAs, we show that regenerating spinal cord axons contain β-actin, GAP-43, Neuritin, Reg3a, Hamp, and Importin β1 mRNAs. " RLID00009764 29423 Gap43 http://www.ncbi.nlm.nih.gov/gene/?term=29423 Basp2 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00009765 29445 Cox4i1 http://www.ncbi.nlm.nih.gov/gene/?term=29445 "Cox4, Cox4a " mRNA Rattus norvegicus 20144716 Axon Neuron qRT-PCR "In this report, we studied cytochrome c oxidase subunit IV (COXIV) mRNA trafficking into distal axons of primary superior cervical ganglia (SCG) neurons. " RLID00009766 2946 GSTM2 http://www.ncbi.nlm.nih.gov/gene/?term=2946 "GST4, GSTM, GSTM2-2, GTHMUS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009767 29477 Mapt http://www.ncbi.nlm.nih.gov/gene/?term=29477 "Mtapt, RNPTAU, Tau, pTau " mRNA Rattus norvegicus 7639096 Axon Neuron Transfection assay "Our results support a novel model in which cis-acting signals, together with RNA-binding proteins are involved in the targeting of tau mRNA, that may ultimately lead to its axonal localization. " RLID00009768 2947 GSTM3 http://www.ncbi.nlm.nih.gov/gene/?term=2947 "GST5, GSTB, GSTM3-3, GTM3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009769 2947 GSTM3 http://www.ncbi.nlm.nih.gov/gene/?term=2947 "GST5, GSTB-3, GTM3, GSTM3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009770 2948 GSTM4 http://www.ncbi.nlm.nih.gov/gene/?term=2948 "GSTM4-4, GTM4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009771 2949 GSTM5 http://www.ncbi.nlm.nih.gov/gene/?term=2949 "GSTM5-5, GTM5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009772 2950 GSTP1 http://www.ncbi.nlm.nih.gov/gene/?term=2950 "DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009773 2950 GSTP1 http://www.ncbi.nlm.nih.gov/gene/?term=2950 "DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009774 2950 GSTP1 http://www.ncbi.nlm.nih.gov/gene/?term=2950 "DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009775 2952 GSTT1 http://www.ncbi.nlm.nih.gov/gene/?term=2952 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009776 29542 Pebp1 http://www.ncbi.nlm.nih.gov/gene/?term=29542 "HCNP, Pbp, Rkip " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00009777 29545 Uchl1 http://www.ncbi.nlm.nih.gov/gene/?term=29545 mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00009778 29545 Uchl1 http://www.ncbi.nlm.nih.gov/gene/?term=29545 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00009779 2954 GSTZ1 http://www.ncbi.nlm.nih.gov/gene/?term=2954 "GSTZ1-1, MAAI, MAI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009780 2954 GSTZ1 http://www.ncbi.nlm.nih.gov/gene/?term=2954 "GSTZ1-1, MAAI, MAI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009781 29565 Eef2 http://www.ncbi.nlm.nih.gov/gene/?term=29565 Ef-2 mRNA Rattus norvegicus 19073915 Dendrite Hippocampus In situ hybridization "We found that RARa protein co-immunoprecipitated with GluR1 mRNA as well as mRNAs encoding GluR2 and eukaryotic elongation factor 2 (eEF2), all of which have been shown to be dendritically localized by in situ hybridization " RLID00009782 2956 MSH6 http://www.ncbi.nlm.nih.gov/gene/?term=2956 "GTBP, GTMBP, HNPCC5, HSAP, p160 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009783 2957 GTF2A1 http://www.ncbi.nlm.nih.gov/gene/?term=2957 "TF2A1, TFIIA, TFIIA-42, TFIIAL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009784 2958 GTF2A2 http://www.ncbi.nlm.nih.gov/gene/?term=2958 "HsT18745, TF2A2, TFIIA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009785 2958 GTF2A2 http://www.ncbi.nlm.nih.gov/gene/?term=2958 "HsT18745, T18745, TF2A2, TFIIA, TFIIA-12, TFIIA-gamma, TFIIAS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009786 29597 P2ry2 http://www.ncbi.nlm.nih.gov/gene/?term=29597 P2Y2 mRNA Rattus norvegicus 12566628 Cytoplasm Thymus|T cell|Endothelial cell In situ hybridization "In the T cells, transcripts for the P2Y(2 )receptor were localised in the cytoplasm as well as on the smooth endoplasmic reticulum and cell membrane. Dividing T cells also expressed P2Y(2 )receptor mRNA, mostly in the cytoplasm around chromosomal material. Endothelial cells displaying labels for P2Y(2 )receptor transcripts were of cortical arteries/arterioles and capillaries and of postcapillary venules in the corticomedullary junction. P2Y(2) mRNA transcripts were localised in the cytoplasm of endothelial cells, although they did not appear to be specifically associated with subcellular organelles or structures. " RLID00009787 29597 P2ry2 http://www.ncbi.nlm.nih.gov/gene/?term=29597 P2Y2 mRNA Rattus norvegicus 12566628 Endoplasmic reticulum Thymus|T cell|Endothelial cell In situ hybridization "In the T cells, transcripts for the P2Y(2 )receptor were localised in the cytoplasm as well as on the smooth endoplasmic reticulum and cell membrane. Dividing T cells also expressed P2Y(2 )receptor mRNA, mostly in the cytoplasm around chromosomal material. Endothelial cells displaying labels for P2Y(2 )receptor transcripts were of cortical arteries/arterioles and capillaries and of postcapillary venules in the corticomedullary junction. P2Y(2) mRNA transcripts were localised in the cytoplasm of endothelial cells, although they did not appear to be specifically associated with subcellular organelles or structures. " RLID00009788 29597 P2ry2 http://www.ncbi.nlm.nih.gov/gene/?term=29597 P2Y2 mRNA Rattus norvegicus 16780199 Cytoplasm Cerebellum In situ hybridization This chapter describes a pre-embedding in situ hybridization method utilizing an immunogold-silver intensification step to identify P2Y2 receptor mRNA transcripts in the adult rat cerebellum. Transcripts were essentially localized in the cytoplasm although they also appeared to be specifically associated with granular endoplasmic reticulum. RLID00009789 29597 P2ry2 http://www.ncbi.nlm.nih.gov/gene/?term=29597 P2Y2 mRNA Rattus norvegicus 16780199 Endoplasmic reticulum Cerebellum In situ hybridization This chapter describes a pre-embedding in situ hybridization method utilizing an immunogold-silver intensification step to identify P2Y2 receptor mRNA transcripts in the adult rat cerebellum. Transcripts were essentially localized in the cytoplasm although they also appeared to be specifically associated with granular endoplasmic reticulum. RLID00009790 2959 GTF2B http://www.ncbi.nlm.nih.gov/gene/?term=2959 "TF2B, TFIIB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009791 2959 GTF2B http://www.ncbi.nlm.nih.gov/gene/?term=2959 "TF2B, TFIIB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009792 2960 GTF2E1 http://www.ncbi.nlm.nih.gov/gene/?term=2960 "FE, TF2E1, TFIIE-A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009793 2960 GTF2E1 http://www.ncbi.nlm.nih.gov/gene/?term=2960 "FE, TF2E1, TFIIE-A " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009794 2960 GTF2E1 http://www.ncbi.nlm.nih.gov/gene/?term=2960 "FE, TF2E1, TFIIE-A " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009795 2961 GTF2E2 http://www.ncbi.nlm.nih.gov/gene/?term=2961 "FE, TF2E2, TFIIE-B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009796 2961 GTF2E2 http://www.ncbi.nlm.nih.gov/gene/?term=2961 "FE, TF2E2, TFIIE-B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009797 29627 Gria2 http://www.ncbi.nlm.nih.gov/gene/?term=29627 "GluA2, GluR-K2, GluR2, gluR-B " mRNA Rattus norvegicus 19073915 Dendrite Hippocampus In situ hybridization "We found that RARa protein co-immunoprecipitated with GluR1 mRNA as well as mRNAs encoding GluR2 and eukaryotic elongation factor 2 (eEF2), all of which have been shown to be dendritically localized by in situ hybridization " RLID00009798 29627 Gria2 http://www.ncbi.nlm.nih.gov/gene/?term=29627 "GluA2, GluR-K2, GluR2, gluR-B " mRNA Rattus norvegicus 23166306 Dendrite Cortical cultures In situ hybridization The hybridization signals of GluA1 and GluA2 mRNAs were present in both the cell soma and dendrites of cultured cortical cells immunolabeled with a specific marker for Microtubule-Associated Protein-2 a (MAP2a). RLID00009799 29627 Gria2 http://www.ncbi.nlm.nih.gov/gene/?term=29627 "GluA2, GluR-K2, GluR2, gluR-B " mRNA Rattus norvegicus 23296627 Dendrite Pyramidal cell Fluorescence in situ hybridization "GluA1-4 subunit mRNAs were highly localized to the apical dendrites of pyramidal cells, whereas in interneurons they were present in multiple dendrites. In contrast, in the dentate gyrus, GluA1-4 subunit mRNAs were virtually restricted to the somata and were absent from the dendrites of granule cells. " RLID00009800 29627 Gria2 http://www.ncbi.nlm.nih.gov/gene/?term=29627 "GluA2, GluR-K2, GluR2, gluR-B " mRNA Rattus norvegicus 23166306 Cell body Cortical cultures In situ hybridization "In vivo, GluA1 and GluA2 mRNAs showed a strong signal in the cell bodies across hippocampal and cortical regions, together with the presence of a clear signal in the proximal dendrites. " RLID00009801 29628 Gria3 http://www.ncbi.nlm.nih.gov/gene/?term=29628 "GLUR3, GluA3, GluR-3, GluR-C, GluR-K3 " mRNA Rattus norvegicus 23296627 Dendrite Pyramidal cell Fluorescence in situ hybridization "GluA1-4 subunit mRNAs were highly localized to the apical dendrites of pyramidal cells, whereas in interneurons they were present in multiple dendrites. In contrast, in the dentate gyrus, GluA1-4 subunit mRNAs were virtually restricted to the somata and were absent from the dendrites of granule cells. " RLID00009802 29629 Gria4 http://www.ncbi.nlm.nih.gov/gene/?term=29629 "GluA4, GluR-D, GluR4 " mRNA Rattus norvegicus 23296627 Dendrite Pyramidal cell Fluorescence in situ hybridization "GluA1-4 subunit mRNAs were highly localized to the apical dendrites of pyramidal cells, whereas in interneurons they were present in multiple dendrites. In contrast, in the dentate gyrus, GluA1-4 subunit mRNAs were virtually restricted to the somata and were absent from the dendrites of granule cells. " RLID00009803 2962 GTF2F1 http://www.ncbi.nlm.nih.gov/gene/?term=2962 "BTF4, RAP74, TF2F1, TFIIF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009804 2962 GTF2F1 http://www.ncbi.nlm.nih.gov/gene/?term=2962 "BTF4, RAP74, TF2F1, TFIIF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009805 2963 GTF2F2 http://www.ncbi.nlm.nih.gov/gene/?term=2963 "BTF4, RAP30, TF2F2, TFIIF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009806 2963 GTF2F2 http://www.ncbi.nlm.nih.gov/gene/?term=2963 "BTF4, RAP30, TF2F2, TFIIF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009807 2965 GTF2H1 http://www.ncbi.nlm.nih.gov/gene/?term=2965 "BTF2, P62, TFB1, TFIIH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009808 2966 GTF2H2 http://www.ncbi.nlm.nih.gov/gene/?term=2966 "BTF2, BTF2P44, T-BTF2P44, TFIIH, p44 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009809 2967 GTF2H3 http://www.ncbi.nlm.nih.gov/gene/?term=2967 "BTF2, P34, TFB4, TFIIH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009810 2967 GTF2H3 http://www.ncbi.nlm.nih.gov/gene/?term=2967 "BTF2, P34, TFB4, TFIIH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009811 2969 GTF2I http://www.ncbi.nlm.nih.gov/gene/?term=2969 "BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009812 2969 GTF2I http://www.ncbi.nlm.nih.gov/gene/?term=2969 "BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009813 29705 Gabra1 http://www.ncbi.nlm.nih.gov/gene/?term=29705 mRNA Rattus norvegicus 9030628 Dendrite Neuron In situ hybridization "With light nonradioactive in situ hybridization (ISH), we observe that GlyR alpha subunit mRNAs are present in both somata and dendrites of most neurons of the ventral horn of rat spinal cord, whereas the beta subunit and gephyrin mRNAs are predominantly in somata. Using a specific monoclonal antibody against α and β subunits of GlyR (mAb 4a) (Pfeiffer et al., 1984), we demonstrated that GlyR α1 " RLID00009814 2970 GTF2IP1 http://www.ncbi.nlm.nih.gov/gene/?term=2970 WBSCR7 lncRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00009815 2970 GTF2IP1 http://www.ncbi.nlm.nih.gov/gene/?term=2970 WBSCR7 lncRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00009816 2971 GTF3A http://www.ncbi.nlm.nih.gov/gene/?term=2971 "AP2, TFIIIA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009817 2971 GTF3A http://www.ncbi.nlm.nih.gov/gene/?term=2971 "AP2, TFIIIA " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009818 2971 GTF3A http://www.ncbi.nlm.nih.gov/gene/?term=2971 "AP2, TFIIIA " mRNA Homo sapiens 24019514 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmid containing either full-length ALPP, t-ftz, AP1, AP2, AP3, AP4, or AP5 and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (C or Ctrl) or HHT (H) for 30 min and then extracted with digitonin. Cells were then fixed, stained for mRNAs using specific FISH probes (ftz probe was used to detect AP1-5), and imaged. Figure 3A, quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 3. " RLID00009819 2971 GTF3A http://www.ncbi.nlm.nih.gov/gene/?term=2971 "AP2, TFIIIA " mRNA Homo sapiens 24019514 Nucleus COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmid containing either full-length ALPP, t-ftz, AP1, AP2, AP3, AP4, or AP5 and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (C or Ctrl) or HHT (H) for 30 min and then extracted with digitonin. Cells were then fixed, stained for mRNAs using specific FISH probes (ftz probe was used to detect AP1-5), and imaged. Figure 3A, quantification of the fluorescence intensities of mRNA in the ER and nucleus. " RLID00009820 2972 BRF1 http://www.ncbi.nlm.nih.gov/gene/?term=2972 "BRF, BRF-1, CFDS, GTF3B, HEL-S-76p, TAF3B2, TAF3C, TAFIII90, TF3B90, TFIIIB90, hBRF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009821 2972 BRF1 http://www.ncbi.nlm.nih.gov/gene/?term=2972 "BRF, BRF-1, CFDS, GTF3B, HEL-S-76p, TAF3B2, TAF3C, TAFIII90, TF3B90, TFIIIB90, hBRF " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009822 2975 GTF3C1 http://www.ncbi.nlm.nih.gov/gene/?term=2975 "TFIIIC, TFIIIC220, TFIIICalpha " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009823 29761 USP25 http://www.ncbi.nlm.nih.gov/gene/?term=29761 USP21 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009824 29761 USP25 http://www.ncbi.nlm.nih.gov/gene/?term=29761 USP21 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009825 29763 PACSIN3 http://www.ncbi.nlm.nih.gov/gene/?term=29763 SDPIII mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009826 29766 TMOD3 http://www.ncbi.nlm.nih.gov/gene/?term=29766 UTMOD mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009827 29766 TMOD3 http://www.ncbi.nlm.nih.gov/gene/?term=29766 UTMOD mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009828 29766 TMOD3 http://www.ncbi.nlm.nih.gov/gene/?term=29766 UTMOD mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009829 29767 TMOD2 http://www.ncbi.nlm.nih.gov/gene/?term=29767 "N-TMOD, NTMOD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009830 29767 TMOD2 http://www.ncbi.nlm.nih.gov/gene/?term=29767 "N-TMOD, NTMOD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009831 2976 GTF3C2 http://www.ncbi.nlm.nih.gov/gene/?term=2976 "TFIIIC-BETA, TFIIIC110 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009832 29775 CARD10 http://www.ncbi.nlm.nih.gov/gene/?term=29775 "BIMP1, CARMA3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009833 29777 ABT1 http://www.ncbi.nlm.nih.gov/gene/?term=29777 hABT1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009834 29780 PARVB http://www.ncbi.nlm.nih.gov/gene/?term=29780 CGI-56 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009835 29781 NCAPH2 http://www.ncbi.nlm.nih.gov/gene/?term=29781 CAPH2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009836 29781 NCAPH2 http://www.ncbi.nlm.nih.gov/gene/?term=29781 CAPH2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009837 29785 CYP2S1 http://www.ncbi.nlm.nih.gov/gene/?term=29785 CYPIIS1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009838 29789 OLA1 http://www.ncbi.nlm.nih.gov/gene/?term=29789 "DOC45, GBP45, GTBP9, GTPBP9, PTD004 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009839 29789 OLA1 http://www.ncbi.nlm.nih.gov/gene/?term=29789 "DOC45, GBP45, GTBP9, GTPBP9, PTD004 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009840 29789 OLA1 http://www.ncbi.nlm.nih.gov/gene/?term=29789 "DOC45, GBP45, GTBP9, GTPBP9, PTD004 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009841 2978 GUCA1A http://www.ncbi.nlm.nih.gov/gene/?term=2978 "C6orf131, COD3, CORD14, GCAP, GCAP1, GUCA, GUCA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009842 29796 UQCR10 http://www.ncbi.nlm.nih.gov/gene/?term=29796 "HSPC051, HSPC119, HSPC151, QCR9, UCCR7.2, UCRC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009843 29796 UQCR10 http://www.ncbi.nlm.nih.gov/gene/?term=29796 "HSPC051, HSPC119, HSPC151, QCR9, UCCR7.2, UCRC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009844 29798 C2orf27A http://www.ncbi.nlm.nih.gov/gene/?term=29798 "C2orf27, C2orf27B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009845 29799 YPEL1 http://www.ncbi.nlm.nih.gov/gene/?term=29799 FKSG3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009846 2979 GUCA1B http://www.ncbi.nlm.nih.gov/gene/?term=2979 "GCAP2, GUCA2, RP48 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009847 2979 GUCA1B http://www.ncbi.nlm.nih.gov/gene/?term=2979 "GCAP2, GUCA2, RP48 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009848 29801 ZDHHC8 http://www.ncbi.nlm.nih.gov/gene/?term=29801 "DHHC8, ZDHHCL1, ZNF378 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009849 29801 ZDHHC8 http://www.ncbi.nlm.nih.gov/gene/?term=29801 "DHHC8, ZDHHCL1, ZNF378 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009850 29803 REPIN1 http://www.ncbi.nlm.nih.gov/gene/?term=29803 "AP4, RIP60, ZNF464, Zfp464 " mRNA Homo sapiens 24019514 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmid containing either full-length ALPP, t-ftz, AP1, AP2, AP3, AP4, or AP5 and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (C or Ctrl) or HHT (H) for 30 min and then extracted with digitonin. Cells were then fixed, stained for mRNAs using specific FISH probes (ftz probe was used to detect AP1-5), and imaged. Figure 3A, quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 3. " RLID00009851 29803 REPIN1 http://www.ncbi.nlm.nih.gov/gene/?term=29803 "AP4, RIP60, ZNF464, Zfp464 " mRNA Homo sapiens 24019514 Nucleus COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmid containing either full-length ALPP, t-ftz, AP1, AP2, AP3, AP4, or AP5 and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (C or Ctrl) or HHT (H) for 30 min and then extracted with digitonin. Cells were then fixed, stained for mRNAs using specific FISH probes (ftz probe was used to detect AP1-5), and imaged. Figure 3A, quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 3. " RLID00009852 29805 Znhit2 http://www.ncbi.nlm.nih.gov/gene/?term=29805 "C11orf5, Fon, ORF6-ps, Znhit2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009853 29809 Rabgap1l http://www.ncbi.nlm.nih.gov/gene/?term=29809 "5830411O09Rik, 8430421H08Rik, 9630005B12Rik, AW049894, HHL, Hh1, mKIAA0471 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009854 29813 Zfp385a http://www.ncbi.nlm.nih.gov/gene/?term=29813 "Hzf, Zfp385, Znf385a " mRNA Mus musculus 25821909 Dendrite Neuron Fluorescence in situ hybridization "DISC1 colocalizes with HZF and ITPR1 mRNA in hippocampal dendrites and directly associates with neuronal mRNAs, including ITPR1 mRNA. DISC1 colocalized with HZF and Itpr1 mRNA in hippocampal dendrites. " RLID00009855 29817 Igfbp7 http://www.ncbi.nlm.nih.gov/gene/?term=29817 "AGM, Fstl2, Mac25 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00009856 29819 Stau2 http://www.ncbi.nlm.nih.gov/gene/?term=29819 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00009857 2983 GUCY1B3 http://www.ncbi.nlm.nih.gov/gene/?term=2983 "GC-S-beta-1, GC-SB3, GUC1B3, GUCB3, GUCSB3, GUCY1B1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009858 29841 GRHL1 http://www.ncbi.nlm.nih.gov/gene/?term=29841 "LBP32, MGR, NH32, TFCP2L2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009859 29841 GRHL1 http://www.ncbi.nlm.nih.gov/gene/?term=29841 "LBP32, MGR, NH32, TFCP2L2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009860 29842 TFCP2L1 http://www.ncbi.nlm.nih.gov/gene/?term=29842 "CRTR1, LBP-9, LBP9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009861 29843 SENP1 http://www.ncbi.nlm.nih.gov/gene/?term=29843 SuPr-2 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009862 29845 Olfr155 http://www.ncbi.nlm.nih.gov/gene/?term=29845 "GA_x5J8B7W5BNN-979337-980296, MOR262-14, OR37A, Olfr37a, mOR37a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009863 29846 Olfr156 http://www.ncbi.nlm.nih.gov/gene/?term=29846 "MOR262-6, OR37B, Olfr37b, mOR37b " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009864 2984 GUCY2C http://www.ncbi.nlm.nih.gov/gene/?term=2984 "DIAR6, GUC2C, MECIL, MUCIL, STAR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009865 29855 UBN1 http://www.ncbi.nlm.nih.gov/gene/?term=29855 "VT, VT4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009866 29859 Sult4a1 http://www.ncbi.nlm.nih.gov/gene/?term=29859 "2400007A17Rik, AI853543, BR-STL-1, ST4A1, Sultx3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009867 29861 Dpf1 http://www.ncbi.nlm.nih.gov/gene/?term=29861 Neud4 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009868 29875 Iqgap1 http://www.ncbi.nlm.nih.gov/gene/?term=29875 "AA682088, D7Ertd237e, D7Ertd257e, mKIAA0051 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009869 29877 Hdgfrp3 http://www.ncbi.nlm.nih.gov/gene/?term=29877 "2700022B06Rik, HRP-3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009870 2987 GUK1 http://www.ncbi.nlm.nih.gov/gene/?term=2987 GMK mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009871 2987 GUK1 http://www.ncbi.nlm.nih.gov/gene/?term=2987 GMK mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009872 29880 ALG5 http://www.ncbi.nlm.nih.gov/gene/?term=29880 bA421P11.2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009873 29880 ALG5 http://www.ncbi.nlm.nih.gov/gene/?term=29880 bA421P11.2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009874 29880 ALG5 http://www.ncbi.nlm.nih.gov/gene/?term=29880 bA421P11.2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009875 29881 NPC1L1 http://www.ncbi.nlm.nih.gov/gene/?term=29881 NPC11L1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009876 29881 NPC1L1 http://www.ncbi.nlm.nih.gov/gene/?term=29881 NPC11L1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009877 29882 ANAPC2 http://www.ncbi.nlm.nih.gov/gene/?term=29882 APC2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009878 29883 CNOT7 http://www.ncbi.nlm.nih.gov/gene/?term=29883 "CAF1, Caf1a, hCAF-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009879 29883 CNOT7 http://www.ncbi.nlm.nih.gov/gene/?term=29883 "CAF-1, CAF1, Caf1a, hCAF-1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009880 29886 SNX8 http://www.ncbi.nlm.nih.gov/gene/?term=29886 Mvp1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009881 29888 STRN4 http://www.ncbi.nlm.nih.gov/gene/?term=29888 "ZIN, zinedin " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009882 29888 STRN4 http://www.ncbi.nlm.nih.gov/gene/?term=29888 "ZIN, zinedin " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009883 29889 GNL2 http://www.ncbi.nlm.nih.gov/gene/?term=29889 "HUMAUANTIG, NGP1, Ngp-1, Nog2, Nug2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009884 29889 GNL2 http://www.ncbi.nlm.nih.gov/gene/?term=29889 "HUMAUANTIG, NGP1, Ngp-1, Nog2, Nug2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009885 29890 RBM15B http://www.ncbi.nlm.nih.gov/gene/?term=29890 "HUMAGCGB, OTT3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009886 29894 CPSF1 http://www.ncbi.nlm.nih.gov/gene/?term=29894 "CPSF160, HSU37012, P/cl.18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009887 29894 CPSF1 http://www.ncbi.nlm.nih.gov/gene/?term=29894 "CPSF160, HSU37012, P/cl.18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009888 29896 TRA2A http://www.ncbi.nlm.nih.gov/gene/?term=29896 "AWMS1, HSU53209 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009889 29899 GPSM2 http://www.ncbi.nlm.nih.gov/gene/?term=29899 "CMCS, DFNB82, LGN, PINS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009890 29899 GPSM2 http://www.ncbi.nlm.nih.gov/gene/?term=29899 "CMCS, DFNB82, LGN, PINS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009891 29899 GPSM2 http://www.ncbi.nlm.nih.gov/gene/?term=29899 "CMCS, DFNB82, LGN, PINS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009892 29901 SAC3D1 http://www.ncbi.nlm.nih.gov/gene/?term=29901 "HSU79266, SHD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009893 29901 SAC3D1 http://www.ncbi.nlm.nih.gov/gene/?term=29901 "HSU79266, SHD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009894 29902 FAM216A http://www.ncbi.nlm.nih.gov/gene/?term=29902 "C12orf24, HSU79274 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009895 29902 FAM216A http://www.ncbi.nlm.nih.gov/gene/?term=29902 "C12orf24, HSU79274 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009896 29903 CCDC106 http://www.ncbi.nlm.nih.gov/gene/?term=29903 "HSU79303, ZNF581 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009897 29904 EEF2K http://www.ncbi.nlm.nih.gov/gene/?term=29904 "HSU93850, eEF-2K " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009898 29904 EEF2K http://www.ncbi.nlm.nih.gov/gene/?term=29904 "HSU93850, eEF-2K " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009899 29907 SNX15 http://www.ncbi.nlm.nih.gov/gene/?term=29907 HSAF001435 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009900 29907 SNX15 http://www.ncbi.nlm.nih.gov/gene/?term=29907 HSAF001435 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009901 29907 SNX15 http://www.ncbi.nlm.nih.gov/gene/?term=29907 HSAF001435 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009902 2990 GUSB http://www.ncbi.nlm.nih.gov/gene/?term=2990 "BG, MPS7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009903 2990 GUSB http://www.ncbi.nlm.nih.gov/gene/?term=2990 "BG, MPS7 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009904 29911 HOOK2 http://www.ncbi.nlm.nih.gov/gene/?term=29911 HK2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009905 29914 UBIAD1 http://www.ncbi.nlm.nih.gov/gene/?term=29914 "SCCD, TERE1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009906 29915 HCFC2 http://www.ncbi.nlm.nih.gov/gene/?term=29915 "HCF-2, HCF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009907 29915 HCFC2 http://www.ncbi.nlm.nih.gov/gene/?term=29915 "HCF-2, HCF2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009908 29916 SNX11 http://www.ncbi.nlm.nih.gov/gene/?term=29916 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009909 29916 SNX11 http://www.ncbi.nlm.nih.gov/gene/?term=29916 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009910 29919 C18orf8 http://www.ncbi.nlm.nih.gov/gene/?term=29919 "HsT2591, MIC1, Mic-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009911 29920 PYCR2 http://www.ncbi.nlm.nih.gov/gene/?term=29920 "HLD10, P5CR2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009912 29923 HILPDA http://www.ncbi.nlm.nih.gov/gene/?term=29923 "C7orf68, HIG-2, HIG2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009913 29926 GMPPA http://www.ncbi.nlm.nih.gov/gene/?term=29926 AAMR mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009914 29927 SEC61A1 http://www.ncbi.nlm.nih.gov/gene/?term=29927 "SEC61, HSEC61, SEC61A " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00009915 29927 SEC61A1 http://www.ncbi.nlm.nih.gov/gene/?term=29927 "HSEC61, SEC61, SEC61A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009916 29927 SEC61A1 http://www.ncbi.nlm.nih.gov/gene/?term=29927 "HSEC61, SEC61, SEC61A " mRNA Homo sapiens 12923260 Ribosome T-cell line Jurkat S1 nuclease protection assays "Using the procedures described above, the subcellular distribution of individual mRNAs in the cytosol and rough ER polysome fractions of Jurkat and J558 cells was determined. As depicted in Figure 4, Sec61u and calnexin were highly enriched in the membrane-bound fraction, as may be predicted for those mRNAs encoding signal sequences. " RLID00009917 29927 SEC61A1 http://www.ncbi.nlm.nih.gov/gene/?term=29927 "HSEC61, SEC61, SEC61A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009918 29927 SEC61A1 http://www.ncbi.nlm.nih.gov/gene/?term=29927 "HSEC61, SEC61, SEC61A " mRNA Homo sapiens 22679391 Cytoplasm U2OS cell RT-PCR "Figure 3A: The levels of Sec61a and b-actin transcripts isolated from unbound (i.e., non-ER) cytoplasmic and ER fractions from either cycloheximide treated (“Control� or puromycin treated EDTA extracted (“Puromycin+EDTA� U2OS cells were assessed by quantitative RT-PCR analysis. " RLID00009919 29927 SEC61A1 http://www.ncbi.nlm.nih.gov/gene/?term=29927 "HSEC61, SEC61, SEC61A " mRNA Homo sapiens 22679391 Endoplasmic reticulum U2OS cell RT-PCR "Figure 3B: The levels of several transcripts in the ER fraction were analyzed as in (A). Measured transcripts include those encoding ER luminal proteins (BiP, Calreticulin), ER membrane proteins (Inositol-3-phosphate Receptor (IP3 Receptor), Sec61α, Trapα, and Fatty Acid Desaturase 3 (FADS3)), a Golgi protein (Mannosidase 2A (Man2A)), plasma membrane proteins (Integrin β1, and Transferrin Receptor (Tf Receptor)), and a secreted protein (Interleukin 7 (IL7)). All measurements were standardized to the level of mRNA in the ER fraction from control cells. Data are collected from Figure 3B. " RLID00009920 29928 TIMM22 http://www.ncbi.nlm.nih.gov/gene/?term=29928 "TEX4, TIM22 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009921 29928 TIMM22 http://www.ncbi.nlm.nih.gov/gene/?term=29928 "TEX4, TIM22 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009922 29929 ALG6 http://www.ncbi.nlm.nih.gov/gene/?term=29929 CDG1C mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009923 29929 ALG6 http://www.ncbi.nlm.nih.gov/gene/?term=29929 CDG1C mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009924 2992 GYG1 http://www.ncbi.nlm.nih.gov/gene/?term=2992 "GSD15, GYG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009925 299331 Hsp90aa1 http://www.ncbi.nlm.nih.gov/gene/?term=299331 "Hsp86, Hsp90, Hspca " mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00009926 299331 Hsp90aa1 http://www.ncbi.nlm.nih.gov/gene/?term=299331 "Hsp86, Hsp90, Hspca " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00009927 29933 GPR132 http://www.ncbi.nlm.nih.gov/gene/?term=29933 G2A mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009928 29934 SNX12 http://www.ncbi.nlm.nih.gov/gene/?term=29934 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009929 29934 SNX12 http://www.ncbi.nlm.nih.gov/gene/?term=29934 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009930 29937 NENF http://www.ncbi.nlm.nih.gov/gene/?term=29937 "CIR2, SCIRP10, SPUF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009931 29937 NENF http://www.ncbi.nlm.nih.gov/gene/?term=29937 "CIR2, SCIRP10, SPUF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009932 29937 NENF http://www.ncbi.nlm.nih.gov/gene/?term=29937 "CIR2, SCIRP10, SPUF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009933 2993 GYPA http://www.ncbi.nlm.nih.gov/gene/?term=2993 "CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009934 2994 GYPB http://www.ncbi.nlm.nih.gov/gene/?term=2994 "CD235b, GPB, GYP, MNS, PAS-3, SS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009935 29950 SERTAD1 http://www.ncbi.nlm.nih.gov/gene/?term=29950 "SEI1, TRIP-Br1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009936 29952 DPP7 http://www.ncbi.nlm.nih.gov/gene/?term=29952 "DPP2, DPPII, QPP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009937 29954 POMT2 http://www.ncbi.nlm.nih.gov/gene/?term=29954 "LGMD2N, MDDGA2, MDDGB2, MDDGC2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009938 29956 CERS2 http://www.ncbi.nlm.nih.gov/gene/?term=29956 "L3, LASS2, SP260, TMSG1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009939 29956 CERS2 http://www.ncbi.nlm.nih.gov/gene/?term=29956 "L3, LASS2, SP260, TMSG1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009940 29957 SLC25A24 http://www.ncbi.nlm.nih.gov/gene/?term=29957 "APC1, SCAMC-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009941 29959 NRBP1 http://www.ncbi.nlm.nih.gov/gene/?term=29959 "BCON3, MADM, MUDPNP, NRBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009942 29959 NRBP1 http://www.ncbi.nlm.nih.gov/gene/?term=29959 "BCON3, MADM, MUDPNP, NRBP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009943 29959 NRBP1 http://www.ncbi.nlm.nih.gov/gene/?term=29959 "BCON3, MADM, MUDPNP, NRBP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009944 2995 GYPC http://www.ncbi.nlm.nih.gov/gene/?term=2995 "CD236, CD236R, GE, GPC, GPD, GYPD, PAS-2, PAS-2' " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009945 29960 FTSJ2 http://www.ncbi.nlm.nih.gov/gene/?term=29960 "FJH1, HEL97, MRM2, RRMJ2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009946 29965 CDIP1 http://www.ncbi.nlm.nih.gov/gene/?term=29965 "C16orf5, CDIP, I1, LITAFL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009947 29966 STRN3 http://www.ncbi.nlm.nih.gov/gene/?term=29966 SG2NA mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009948 29966 STRN3 http://www.ncbi.nlm.nih.gov/gene/?term=29966 SG2NA mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009949 29966 STRN3 http://www.ncbi.nlm.nih.gov/gene/?term=29966 SG2NA mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009950 29967 LRP12 http://www.ncbi.nlm.nih.gov/gene/?term=29967 ST7 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009951 29968 PSAT1 http://www.ncbi.nlm.nih.gov/gene/?term=29968 "EPIP, NLS2, PSA, PSAT, PSATD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009952 29969 MDFIC http://www.ncbi.nlm.nih.gov/gene/?term=29969 HIC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009953 29969 MDFIC http://www.ncbi.nlm.nih.gov/gene/?term=29969 HIC mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009954 29969 MDFIC http://www.ncbi.nlm.nih.gov/gene/?term=29969 HIC mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009955 2996 GYPE http://www.ncbi.nlm.nih.gov/gene/?term=2996 "GPE, MNS, MiIX " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009956 29974 A1CF http://www.ncbi.nlm.nih.gov/gene/?term=29974 "ACF, ACF64, ACF65, APOBEC1CF, ASP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009957 29979 UBQLN1 http://www.ncbi.nlm.nih.gov/gene/?term=29979 "DA41, DSK2, PLIC-1, UBQN, XDRP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009958 29979 UBQLN1 http://www.ncbi.nlm.nih.gov/gene/?term=29979 "DA41, DSK2, PLIC-1, UBQN, XDRP1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009959 29979 UBQLN1 http://www.ncbi.nlm.nih.gov/gene/?term=29979 "DA41, DSK2, PLIC-1, UBQN, XDRP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009960 2997 GYS1 http://www.ncbi.nlm.nih.gov/gene/?term=2997 "GSY, GYS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009961 29980 DONSON http://www.ncbi.nlm.nih.gov/gene/?term=29980 "B17, C21orf60 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009962 29980 DONSON http://www.ncbi.nlm.nih.gov/gene/?term=29980 "B17, C21orf60 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009963 29982 NRBF2 http://www.ncbi.nlm.nih.gov/gene/?term=29982 "COPR, COPR1, COPR2, NRBF-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009964 29982 NRBF2 http://www.ncbi.nlm.nih.gov/gene/?term=29982 "COPR, COPR1, COPR2, NRBF-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009965 29982 NRBF2 http://www.ncbi.nlm.nih.gov/gene/?term=29982 "COPR, COPR1, COPR2, NRBF-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00009966 29984 RHOD http://www.ncbi.nlm.nih.gov/gene/?term=29984 "ARHD, RHOHP1, RHOM, Rho " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009967 29984 RHOD http://www.ncbi.nlm.nih.gov/gene/?term=29984 "ARHD, RHOHP1, RHOM, Rho " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009968 29985 SLC39A3 http://www.ncbi.nlm.nih.gov/gene/?term=29985 "ZIP-3, ZIP3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009969 29985 SLC39A3 http://www.ncbi.nlm.nih.gov/gene/?term=29985 "ZIP-3, ZIP3 " mRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00009970 29988 SLC2A8 http://www.ncbi.nlm.nih.gov/gene/?term=29988 "GLUT8, GLUTX1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009971 29990 PILRB http://www.ncbi.nlm.nih.gov/gene/?term=29990 "FDFACT1, FDFACT2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009972 29990 PILRB http://www.ncbi.nlm.nih.gov/gene/?term=29990 "FDFACT1, FDFACT2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009973 29994 BAZ2B http://www.ncbi.nlm.nih.gov/gene/?term=29994 WALp4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009974 29994 BAZ2B http://www.ncbi.nlm.nih.gov/gene/?term=29994 WALp4 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009975 29997 GLTSCR2 http://www.ncbi.nlm.nih.gov/gene/?term=29997 "PICT-1, PICT1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009976 29 ABR http://www.ncbi.nlm.nih.gov/gene/?term=29 MDB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009977 30000 TNPO2 http://www.ncbi.nlm.nih.gov/gene/?term=30000 "IPO3, KPNB2B, TRN2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009978 30000 TNPO2 http://www.ncbi.nlm.nih.gov/gene/?term=30000 "IPO3, KPNB2B, TRN2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009979 30001 ERO1A http://www.ncbi.nlm.nih.gov/gene/?term=30001 "ERO1-L, ERO1-L-alpha, ERO1-alpha, ERO1L, ERO1LA, Ero1alpha " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009980 30001 ERO1A http://www.ncbi.nlm.nih.gov/gene/?term=30001 "ERO1-L, ERO1-L-alpha, ERO1-alpha, ERO1L, ERO1LA, Ero1alpha " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009981 30001 ERO1A http://www.ncbi.nlm.nih.gov/gene/?term=30001 "ERO1-L, ERO1-L-alpha, ERO1-alpha, ERO1L, ERO1LA, Ero1alpha " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00009982 30046 Zfp292 http://www.ncbi.nlm.nih.gov/gene/?term=30046 "5730450D02Rik, 5830493J20Rik, 9430062L07Rik, AI449016, Krox-10, Zfp-15, Zfp15, Zn-15, Zn-16, mKIAA0530 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00009983 3005 H1F0 http://www.ncbi.nlm.nih.gov/gene/?term=3005 "H10, H1FV " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009984 30061 SLC40A1 http://www.ncbi.nlm.nih.gov/gene/?term=30061 "FPN1, HFE4, IREG1, MST079, MSTP079, MTP1, SLC11A3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009985 3006 HIST1H1C http://www.ncbi.nlm.nih.gov/gene/?term=3006 "H1.2, H1C, H1F2, H1s-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009986 3006 HIST1H1C http://www.ncbi.nlm.nih.gov/gene/?term=3006 "H1.2, H1C, H1F2, H1s-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009987 3008 HIST1H1E http://www.ncbi.nlm.nih.gov/gene/?term=3008 "H1.4, H1E, H1F4, H1s-4, dJ221C16.5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009988 30122 wnt8a http://www.ncbi.nlm.nih.gov/gene/?term=30122 "wnt-8, wnt8, wnt8.1, wu:fa20e02, wu:fe05d07 " mRNA Danio rerio 22949618 Vegetal Embryo Fluorescence in situ hybridization "Injected fluorescent wnt8a RNA localizes asymmetrically to the vegetal lateral cortex (yellow arrowheads in I) and to the blastoderm (red asterisk in I), similar to endogenous wnt8a transcripts. " RLID00009989 30122 wnt8a http://www.ncbi.nlm.nih.gov/gene/?term=30122 "wnt-8, wnt8, wnt8.1, wu:fa20e02, wu:fe05d07 " mRNA Danio rerio 26528729 Vegetal Embryo Whole mount in situ hybridization Whole mount in situ hybridization shows that grip2a and wnt8a mRNA are localized at the base of the vegetal cortex and experience an off-cen-ter shift in control (DMSO-treated) embryos RLID00009990 30122 wnt8a http://www.ncbi.nlm.nih.gov/gene/?term=30122 "wnt-8, wnt8, wnt8.1, wu:fa20e02, wu:fe05d07 " mRNA Danio rerio 26528729 Vegetal Embryo Fluorescence in situ hybridization "FIGURE 2. Dual label FISH of pairwise comparisons of wnt8a, grip2a and dazl mRNA localization at the vegetal cortex. (A-C) dazl (green) and wnt8a (red). (D-F) grip2a (green) and dazl (red). (G-I) grip2a (green) and wnt8a (red). In all cases mRNAs localize to discrete units, which do not overlap between different RNAs. Embryos are wild type fixed at 20mpf. Panels are 2-D projections of imaged vegetal cortex samples. Scale bar in (I) represents 5mm for all images. (Color figure available online.) " RLID00009991 3012 HIST1H2AE http://www.ncbi.nlm.nih.gov/gene/?term=3012 "H2A.1, H2A.2, H2A/a, H2AFA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009992 3012 HIST1H2AE http://www.ncbi.nlm.nih.gov/gene/?term=3012 "H2A.1, H2A.2, H2A/a, H2AFA " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00009993 3014 H2AFX http://www.ncbi.nlm.nih.gov/gene/?term=3014 "H2A.X, H2A/X, H2AX " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009994 3014 H2AFX http://www.ncbi.nlm.nih.gov/gene/?term=3014 "H2A.X, H2A/X, H2AX " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009995 3015 H2AFZ http://www.ncbi.nlm.nih.gov/gene/?term=3015 "H2A.Z-1, H2A.z, H2A/z, H2AZ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009996 3017 HIST1H2BD http://www.ncbi.nlm.nih.gov/gene/?term=3017 "H2B.1B, H2B/b, H2BFB, HIRIP2, dJ221C16.6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009997 3017 HIST1H2BD http://www.ncbi.nlm.nih.gov/gene/?term=3017 "H2B.1B, H2B/b, H2BFB, HIRIP2, dJ221C16.6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00009998 301 ANXA1 http://www.ncbi.nlm.nih.gov/gene/?term=301 "ANX1, LPC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00009999 301 ANXA1 http://www.ncbi.nlm.nih.gov/gene/?term=301 "ANX1, LPC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010000 301 ANXA1 http://www.ncbi.nlm.nih.gov/gene/?term=301 "ANX1, LPC1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010001 3020 H3F3A http://www.ncbi.nlm.nih.gov/gene/?term=3020 "H3.3A, H3F3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010002 3020 H3F3A http://www.ncbi.nlm.nih.gov/gene/?term=3020 "H3.3A, H3F3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010003 3020 H3F3A http://www.ncbi.nlm.nih.gov/gene/?term=3020 "H3.3A, H3F3 " mRNA Homo sapiens 21431749 Cytosol HEK293 cell Northern blot "Similarly, Northern blot analysis of the mRNA composition of the cytosol and membrane fractions show that the cytosol fraction is enriched for mRNAs encoding histone (H3F3A) and GAPDH, whereas the membrane fraction is enriched in mRNAs encoding ER resident proteins, such as GRP94 and calreticulin (Fig. 2 B). " RLID00010004 3021 H3F3B http://www.ncbi.nlm.nih.gov/gene/?term=3021 H3.3B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010005 30263 ddx4 http://www.ncbi.nlm.nih.gov/gene/?term=30263 "vas, vasa, vlg, wu:fi24g05, zgc:109812, zgc:158535 " mRNA Danio rerio 10811828 Germ plasm Embryo In situ hybridization "To understand the structural nature of localized vasa RNA aggregates in zebrafish embryogenesis, we performed transmission electron microscopy on four-cell embryos that are labeled for vasa RNA using in situ hybridization and an electron-dense substrate (see Materials and Methods)..Based on the presence of the vasa RNA, which is embedded in electron-dense material that resembles nuage, we conclude that this structure is the zebrafish germ plasm. " RLID00010006 30263 ddx4 http://www.ncbi.nlm.nih.gov/gene/?term=30263 "vas, vasa, vlg, wu:fi24g05, zgc:109812, zgc:158535 " mRNA Danio rerio 16457796 Germ plasm Embryo Fluorescence in situ hybridization "Fig. 1. Endogenous patterns of RNA localization of dnd, nos1, vas, and dazl RNAs during the first cell cycle. Animal views of embryos fixed at progressively older stages of development (A-D: 15 min p.f.; E-H: 30 min. p.f.; I-L: 45 min p.f.) and labeled using FISH to detect germ plasm RNAs (dnd (A, E, I); nos1 (B, F, J); vas(C,G, K); dazl (D, H, L). (A-D) Immediately after fertilization, dnd, nos1, and vas RNA aggregates can be observed as a band at the animal pole, while dazl RNA aggregates are not initially present in the animal pole. (E-H) During the initiation of furrow formation, RNA aggregates fordnd, nos1, and vas begin to be recruited as a rod at the forming furrow (arrows in E-G). At this stage, dazl RNA is not yet detectable at the furrows (H). (I-L) As the furrow matures, there is an increase in the amount of dnd, nos1, and vasRNAs recruited at the furrow, and dazlRNA becomes detectable at the furrow (arrows in I-L). Scale bar in panel (L) represents 100 μmThus, although all four RNAs are recruited to the forming furrow, RNAs for dnd, nos1, and vas are already present in the animal pole in the freshly laid egg, while dazlRNA arrives to the animal pole from the vegetal region at a later stage. Based on their different times of appearance at the animal region, we refer to the dnd, nos1, and vas RNAs as the early animal germ plasm RNAs, while dazl is also referred to as a vegetally localized germ plasm RNA. " RLID00010007 30263 ddx4 http://www.ncbi.nlm.nih.gov/gene/?term=30263 "vas, vasa, vlg, wu:fi24g05, zgc:109812, zgc:158535 " mRNA Danio rerio 17217535 Germ plasm Embryo In situ hybridization "This finding, coupled with the fact that vasa mRNA, which is localized to the germ plasm of zebrafish but does not label a similar structure in medaka opened the possibility of fundamentally different mechanisms governing PGC specification in these two fish species. " RLID00010008 30263 ddx4 http://www.ncbi.nlm.nih.gov/gene/?term=30263 "vas, vasa, vlg, wu:fi24g05, zgc:109812, zgc:158535 " mRNA Danio rerio 17293094 Germ plasm Oocyte In situ hybridization "Here we report that the germ plasm RNAs vasa, nanos1, and dazl co-localize with the mitochondrial cloud (MC) and are transported to the vegetal cortex during early oogenesis. " RLID00010009 30263 ddx4 http://www.ncbi.nlm.nih.gov/gene/?term=30263 "vas, vasa, vlg, wu:fi24g05, zgc:109812, zgc:158535 " mRNA Danio rerio 17293094 Mitochondrion Oocyte In situ hybridization "Here we report that the germ plasm RNAs vasa, nanos1, and dazl co-localize with the mitochondrial cloud (MC) and are transported to the vegetal cortex during early oogenesis. " RLID00010010 30263 ddx4 http://www.ncbi.nlm.nih.gov/gene/?term=30263 "vas, vasa, vlg, wu:fi24g05, zgc:109812, zgc:158535 " mRNA Danio rerio 24967891 Germ plasm Embryo In situ hybridization "The localization patterns of dazl mRNA, a germ plasm component initially localized to the vegetal pole of the egg ([36,46,47]; Figure 8A), is not affected in these mutants (Figure 8D). During the first two cell cycles, dazl mRNA localizes normally to the furrows in hec mutants (Figure 8B, 8E), as does vasa mRNA (Figure 8C, 8F), an animal germ plasm component already present in the animal cortical region during egg activation. " RLID00010011 3028 HSD17B10 http://www.ncbi.nlm.nih.gov/gene/?term=3028 "17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010012 3028 HSD17B10 http://www.ncbi.nlm.nih.gov/gene/?term=3028 "17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010013 3028 HSD17B10 http://www.ncbi.nlm.nih.gov/gene/?term=3028 "17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010014 3029 HAGH http://www.ncbi.nlm.nih.gov/gene/?term=3029 "GLO2, GLX2, GLXII1, HAGH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010015 302 ANXA2 http://www.ncbi.nlm.nih.gov/gene/?term=302 "ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010016 302 ANXA2 http://www.ncbi.nlm.nih.gov/gene/?term=302 "ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010017 302 ANXA2 http://www.ncbi.nlm.nih.gov/gene/?term=302 "ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010018 3030 HADHA http://www.ncbi.nlm.nih.gov/gene/?term=3030 "ECHA, GBP, HADH, LCEH, LCHAD, MTPA, TP-ALPHA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010019 3030 HADHA http://www.ncbi.nlm.nih.gov/gene/?term=3030 "ECHA, GBP, HADH, LCEH, LCHAD, MTPA, TP-ALPHA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010020 3032 HADHB http://www.ncbi.nlm.nih.gov/gene/?term=3032 "ECHB, MSTP029, MTPB, TP-BETA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010021 3033 HADH http://www.ncbi.nlm.nih.gov/gene/?term=3033 "HAD, HADH1, HADHSC, HCDH, HHF4, MSCHAD, SCHAD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010022 3033 HADH http://www.ncbi.nlm.nih.gov/gene/?term=3033 "HAD1, HADHSC, HCDH, HHF4, MSCHAD, SCHAD, HADH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010023 3033 HADH http://www.ncbi.nlm.nih.gov/gene/?term=3033 "HAD1, HADHSC, HCDH, HHF4, MSCHAD, SCHAD, HADH " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010024 3035 HARS http://www.ncbi.nlm.nih.gov/gene/?term=3035 "CMT2W, HRS, USH3B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010025 3039 HBA1 http://www.ncbi.nlm.nih.gov/gene/?term=3039 "HBA-T3, HBH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010026 3040 HBA2 http://www.ncbi.nlm.nih.gov/gene/?term=3040 "HBA-T2, HBH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010027 3040 HBA2 http://www.ncbi.nlm.nih.gov/gene/?term=3040 "HBA-T2, HBH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010028 3043 HBB http://www.ncbi.nlm.nih.gov/gene/?term=3043 "CD113t-C, beta-globin " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010029 3046 HBE1 http://www.ncbi.nlm.nih.gov/gene/?term=3046 HBE mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010030 3052 HCCS http://www.ncbi.nlm.nih.gov/gene/?term=3052 "CCHL, LSDMCA1, MCOPS7, MLS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010031 3052 HCCS http://www.ncbi.nlm.nih.gov/gene/?term=3052 "CCHL, LSDMCA1, MCOPS7, MLS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010032 3054 HCFC1 http://www.ncbi.nlm.nih.gov/gene/?term=3054 "CFF, HCF, HCF-1, HCF1, HFC1, MRX3, PPP1R89, VCAF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010033 3054 HCFC1 http://www.ncbi.nlm.nih.gov/gene/?term=3054 "CFF, HCF, HCF-1, HCF1, HFC1, MRX3, PPP1R89, VCAF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010034 3059 HCLS1 http://www.ncbi.nlm.nih.gov/gene/?term=3059 "CTTNL, HS1, lckBP1, p75 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010035 3061 HCRTR1 http://www.ncbi.nlm.nih.gov/gene/?term=3061 OX1R mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010036 3064 HTT http://www.ncbi.nlm.nih.gov/gene/?term=3064 "HD, IT15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010037 3064 HTT http://www.ncbi.nlm.nih.gov/gene/?term=3064 "HD, IT15 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010038 3064 HTT http://www.ncbi.nlm.nih.gov/gene/?term=3064 "HD, IT15 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010039 3065 HDAC1 http://www.ncbi.nlm.nih.gov/gene/?term=3065 "GON-10, HD1, RPD3, RPD3L1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010040 3065 HDAC1 http://www.ncbi.nlm.nih.gov/gene/?term=3065 "HD1, RPD3, GON-10, RPD3L1 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00010041 3065 HDAC1 http://www.ncbi.nlm.nih.gov/gene/?term=3065 "GON-10, HD1, RPD3, RPD3L1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010042 3065 HDAC1 http://www.ncbi.nlm.nih.gov/gene/?term=3065 "GON-10, HD1, RPD3, RPD3L1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010043 3066 HDAC2 http://www.ncbi.nlm.nih.gov/gene/?term=3066 "HD2, RPD3, YAF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010044 3066 HDAC2 http://www.ncbi.nlm.nih.gov/gene/?term=3066 "HD2, RPD3, YAF1 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00010045 3066 HDAC2 http://www.ncbi.nlm.nih.gov/gene/?term=3066 "HD2, RPD3, YAF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010046 3066 HDAC2 http://www.ncbi.nlm.nih.gov/gene/?term=3066 "HD2, RPD3, YAF1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010047 3066 HDAC2 http://www.ncbi.nlm.nih.gov/gene/?term=3066 "HD2, RPD3, YAF1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010048 3066 HDAC2 http://www.ncbi.nlm.nih.gov/gene/?term=3066 "HD2, RPD3, YAF1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010049 3068 HDGF http://www.ncbi.nlm.nih.gov/gene/?term=3068 HMG1L2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010050 3068 HDGF http://www.ncbi.nlm.nih.gov/gene/?term=3068 HMG1L2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010051 3068 HDGF http://www.ncbi.nlm.nih.gov/gene/?term=3068 HMG1L2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010052 3069 HDLBP http://www.ncbi.nlm.nih.gov/gene/?term=3069 "HBP, PRO2900, VGL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010053 3069 HDLBP http://www.ncbi.nlm.nih.gov/gene/?term=3069 "HBP, PRO2900, VGL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010054 3070 HELLS http://www.ncbi.nlm.nih.gov/gene/?term=3070 "LSH, Nbla10143, PASG, SMARCA6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010055 3071 NCKAP1L http://www.ncbi.nlm.nih.gov/gene/?term=3071 HEM1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010056 3073 HEXA http://www.ncbi.nlm.nih.gov/gene/?term=3073 TSD mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010057 3073 HEXA http://www.ncbi.nlm.nih.gov/gene/?term=3073 TSD mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010058 3073 HEXA http://www.ncbi.nlm.nih.gov/gene/?term=3073 TSD mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010059 3074 HEXB http://www.ncbi.nlm.nih.gov/gene/?term=3074 "ENC-1AS, HEL-248, HEL-S-111 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010060 3074 HEXB http://www.ncbi.nlm.nih.gov/gene/?term=3074 "ENC-1AS, HEL-248, HEL-S-111 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010061 3074 HEXB http://www.ncbi.nlm.nih.gov/gene/?term=3074 "ENC-1AS, HEL-248, HEL-S-111 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010062 3077 HFE http://www.ncbi.nlm.nih.gov/gene/?term=3077 "HFE1, HH, HLA-H, MVCD7, TFQTL2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010063 3078 CFHR1 http://www.ncbi.nlm.nih.gov/gene/?term=3078 "CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, H36-1, H36-2, HFL1, HFL2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010064 30795 Fkbp3 http://www.ncbi.nlm.nih.gov/gene/?term=30795 "25kDa, FKBP-3, FKBP25 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010065 307 ANXA4 http://www.ncbi.nlm.nih.gov/gene/?term=307 "ANX4, HEL-S-274, PIG28, ZAP36 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010066 307 ANXA4 http://www.ncbi.nlm.nih.gov/gene/?term=307 "ANX4, HEL-S-274, P32.5, PAP-II, PIG28, PP4-X, ZAP36 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010067 307 ANXA4 http://www.ncbi.nlm.nih.gov/gene/?term=307 "ANX4, HEL-S-274, P32.5, PAP-II, PIG28, PP4-X, ZAP36 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010068 30811 HUNK http://www.ncbi.nlm.nih.gov/gene/?term=30811 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010069 30811 HUNK http://www.ncbi.nlm.nih.gov/gene/?term=30811 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010070 30815 ST6GALNAC6 http://www.ncbi.nlm.nih.gov/gene/?term=30815 "SIAT7-F, SIAT7F, ST6GALNACVI " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010071 30818 KCNIP3 http://www.ncbi.nlm.nih.gov/gene/?term=30818 "CSEN, DREAM, KCHIP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010072 30827 CXXC1 http://www.ncbi.nlm.nih.gov/gene/?term=30827 "2410002I16Rik, 5830420C16Rik, CFP1, CGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1, hCGBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010073 30827 CXXC1 http://www.ncbi.nlm.nih.gov/gene/?term=30827 "2410002I16Rik, 5830420C16Rik, CFP1, CGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1, hCGBP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010074 3082 HGF http://www.ncbi.nlm.nih.gov/gene/?term=3082 "DFNB39, F-TCF, HGFB, HPTA, SF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010075 30833 NT5C http://www.ncbi.nlm.nih.gov/gene/?term=30833 "DNT, DNT1, HEL74, P5N2, PN-I, PN-II, UMPH2, cdN, dNT-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010076 30833 NT5C http://www.ncbi.nlm.nih.gov/gene/?term=30833 "DNT, DNT1, HEL74, P5N2, PN-I, PN-II, UMPH2, cdN, dNT-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010077 30833 NT5C http://www.ncbi.nlm.nih.gov/gene/?term=30833 "DNT, DNT1, HEL74, P5N2, PN-I, PN-II, UMPH2, cdN, dNT-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010078 30834 ZNRD1 http://www.ncbi.nlm.nih.gov/gene/?term=30834 "HTEX-6, HTEX6, Rpa12, TCTEX6, TEX6, ZR14, hZR14, tctex-6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010079 30834 ZNRD1 http://www.ncbi.nlm.nih.gov/gene/?term=30834 "HTEX-6, HTEX6, Rpa12, TCTEX6, TEX6, ZR14, hZR14, tctex-6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010080 30835 CD209 http://www.ncbi.nlm.nih.gov/gene/?term=30835 "CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010081 30835 CD209 http://www.ncbi.nlm.nih.gov/gene/?term=30835 "CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010082 30836 DNTTIP2 http://www.ncbi.nlm.nih.gov/gene/?term=30836 "ERBP, FCF2, HSU15552, LPTS-RP2, TdIF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010083 30836 DNTTIP2 http://www.ncbi.nlm.nih.gov/gene/?term=30836 "ERBP, FCF2, HSU15552, LPTS-RP2, TdIF2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010084 30837 SOCS7 http://www.ncbi.nlm.nih.gov/gene/?term=30837 "NAP4, NCKAP4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010085 30837 SOCS7 http://www.ncbi.nlm.nih.gov/gene/?term=30837 "NAP4, NCKAP4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010086 30838 Fbxw4 http://www.ncbi.nlm.nih.gov/gene/?term=30838 "Dac, Fbw4, SHFM3, SHSF3, dactylin, dactylyn " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010087 30839 Fbxw5 http://www.ncbi.nlm.nih.gov/gene/?term=30839 "AI159739, Fbw5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010088 30841 Kdm2b http://www.ncbi.nlm.nih.gov/gene/?term=30841 "Cxxc2, Fbl10, Fbxl10, Jhdm1b, PCCX2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010089 30844 EHD4 http://www.ncbi.nlm.nih.gov/gene/?term=30844 PAST4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010090 30844 EHD4 http://www.ncbi.nlm.nih.gov/gene/?term=30844 PAST4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010091 30846 EHD2 http://www.ncbi.nlm.nih.gov/gene/?term=30846 PAST2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010092 30846 EHD2 http://www.ncbi.nlm.nih.gov/gene/?term=30846 PAST2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010093 30849 PIK3R4 http://www.ncbi.nlm.nih.gov/gene/?term=30849 "VPS15, p150 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010094 30849 PIK3R4 http://www.ncbi.nlm.nih.gov/gene/?term=30849 "VPS15, p150 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010095 3084 NRG1 http://www.ncbi.nlm.nih.gov/gene/?term=3084 "ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010096 30851 TAX1BP3 http://www.ncbi.nlm.nih.gov/gene/?term=30851 "TIP-1, TIP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010097 30851 TAX1BP3 http://www.ncbi.nlm.nih.gov/gene/?term=30851 "TIP-1, TIP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010098 30851 TAX1BP3 http://www.ncbi.nlm.nih.gov/gene/?term=30851 "TIP-1, TIP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010099 30877 Gnl3 http://www.ncbi.nlm.nih.gov/gene/?term=30877 Ns mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010100 30878 Apln http://www.ncbi.nlm.nih.gov/gene/?term=30878 "6030430G11Rik, Apel " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010101 308 ANXA5 http://www.ncbi.nlm.nih.gov/gene/?term=308 "ANX5, ENX2, HEL-S-7, PP4, RPRGL3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010102 309122 H19 http://www.ncbi.nlm.nih.gov/gene/?term=309122 "ASM, ASM1, D11S813E " lncRNA Rattus norvegicus 15094229 Cytoplasm Hepatocyte In situ hybridization "Similar to albumin mRNA, H19 mRNA appeared to be localized mainly in the cytoplasm. " RLID00010103 3091 HIF1A http://www.ncbi.nlm.nih.gov/gene/?term=3091 "HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010104 3091 HIF1A http://www.ncbi.nlm.nih.gov/gene/?term=3091 "HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010105 3091 HIF1A http://www.ncbi.nlm.nih.gov/gene/?term=3091 "HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010106 3091 HIF1A http://www.ncbi.nlm.nih.gov/gene/?term=3091 "HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00010107 3091 HIF1A http://www.ncbi.nlm.nih.gov/gene/?term=3091 "HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 " mRNA Homo sapiens 25753659 Ribosome HT1080 cell qRT-PCR Figure S1: Polysomal gradient analysis. HT1080 cells were incubated under control (21% oxygen) or hypoxic (1% oxygen) conditions for up to 36 h as described in Figure 1. Shown are representative original RT-PCR data (30 cycles for beta-Actin and the external standard [extSt]; 35 cycles for the other genes) from pooled samples to visualize mRNA distribution following fractionation of sucrose gradients at control conditions (C) and 36 h of hypoxia (Hy). The external standard (a synthetic in vitro transcript) was diluted to appropriate concentration for qPCR and added directly after gradient fractionation and prior to RNA isolation as a technical control. The external standard served for fraction dependent normalization. RLID00010108 3092 HIP1 http://www.ncbi.nlm.nih.gov/gene/?term=3092 "HIP-I, ILWEQ, SHON, SHONbeta, SHONgamma " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010109 3092 HIP1 http://www.ncbi.nlm.nih.gov/gene/?term=3092 "HIP-I, ILWEQ, SHON, SHONbeta, SHONgamma " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010110 3092 HIP1 http://www.ncbi.nlm.nih.gov/gene/?term=3092 "HIP-I, ILWEQ, SHON, SHONbeta, SHONgamma " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010111 30930 Vps26a http://www.ncbi.nlm.nih.gov/gene/?term=30930 "AA407240, HB58, Vps26 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010112 30931 Tor1a http://www.ncbi.nlm.nih.gov/gene/?term=30931 "DQ2, Dyt1, torsinA " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010113 30934 Tor1b http://www.ncbi.nlm.nih.gov/gene/?term=30934 "2610016F05Rik, DQ1, torsinB " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010114 3093 UBE2K http://www.ncbi.nlm.nih.gov/gene/?term=3093 "E2-25K, HIP2, HYPG, LIG, UBC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010115 3093 UBE2K http://www.ncbi.nlm.nih.gov/gene/?term=3093 "E2-25K, HIP2, HYPG, LIG, UBC1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010116 30940 Usp25 http://www.ncbi.nlm.nih.gov/gene/?term=30940 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010117 30940 Usp25 http://www.ncbi.nlm.nih.gov/gene/?term=30940 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010118 30944 Zfp354c http://www.ncbi.nlm.nih.gov/gene/?term=30944 "5330421P20Rik, AJ18, AW743325, Kid3, Tcf17l2, Znf354c, mKIAA4218 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010119 30947 Adat1 http://www.ncbi.nlm.nih.gov/gene/?term=30947 "MMADAT1, mADAT1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010120 3094 HINT1 http://www.ncbi.nlm.nih.gov/gene/?term=3094 "HINT, NMAN, PKCI-1, PRKCNH1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010121 3094 HINT1 http://www.ncbi.nlm.nih.gov/gene/?term=3094 "HINT, NMAN, PKCI-1, PRKCNH1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010122 3094 HINT1 http://www.ncbi.nlm.nih.gov/gene/?term=3094 "HINT, NMAN, PKCI-1, PRKCNH1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010123 30957 Mapk8ip3 http://www.ncbi.nlm.nih.gov/gene/?term=30957 "BB120594, D17Wsu15e, JIP-3, JSAP1, JSAP1a, JSAP1b, JSAP1c, JSAP1d, Jip3, Syd2, mKIAA1066 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010124 30960 Vapa http://www.ncbi.nlm.nih.gov/gene/?term=30960 "33kDa, VAP33 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010125 30968 STOML2 http://www.ncbi.nlm.nih.gov/gene/?term=30968 "HSPC108, SLP-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010126 3096 HIVEP1 http://www.ncbi.nlm.nih.gov/gene/?term=3096 "CIRIP, CRYBP1, GAAP, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40, ZNF40A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010127 3099 HK2 http://www.ncbi.nlm.nih.gov/gene/?term=3099 "HKII, HXK2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010128 3099 HK2 http://www.ncbi.nlm.nih.gov/gene/?term=3099 "HKII, HXK2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010129 3099 HK2 http://www.ncbi.nlm.nih.gov/gene/?term=3099 "HKII, HXK2 " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00010130 309 ANXA6 http://www.ncbi.nlm.nih.gov/gene/?term=309 "ANX6, CBP68 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010131 309 ANXA6 http://www.ncbi.nlm.nih.gov/gene/?term=309 "ANX6, CBP68 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010132 30 ACAA1 http://www.ncbi.nlm.nih.gov/gene/?term=30 "ACAA, PTHIO, THIO " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010133 31011 Dredd http://www.ncbi.nlm.nih.gov/gene/?term=31011 "Dmel_CG7486, CASP8_DROME, CG7486, DCP-2, DCP-2/DREDD, DCP2, DREDD, Dcp-2, Dcp-2/Dredd, Dcp2, Dedd, Dmel\CG7486/DCP-2, EG:115C2.9, Redd, anon-1BCa, dDredd, dcp-2/dredd, dredd, Dredd " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010134 31017 sdk http://www.ncbi.nlm.nih.gov/gene/?term=31017 "Dmel_CG5227, BcDNA:LD22322, BcDNA:RE63453, CG5227, CT16627, Dmel\CG5227, EG:BACR19J1.1 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010135 31017 sdk http://www.ncbi.nlm.nih.gov/gene/?term=31017 "Dmel_CG5227, BcDNA:LD22322, BcDNA:RE63453, CG5227, CT16627, Dmel\CG5227, EG:BACR19J1.1 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010136 31026 CG16989 http://www.ncbi.nlm.nih.gov/gene/?term=31026 "Dmel_ Dmel\CG16989, EG:34F3.4 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010137 31027 Rbf http://www.ncbi.nlm.nih.gov/gene/?term=31027 "Dmel_CG7413, CG7413, Dmel\CG7413, EG:34F3.3, FBF, RB, RBF, RBF1, Rb, Rb1, RbF1, dRBF, pRb, rb, rbf, rbf1, Rbf " mRNA Drosophila melanogaster 17923096 Posterior Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00010138 31043 CG3704 http://www.ncbi.nlm.nih.gov/gene/?term=31043 "Dmel_ Dmel\CG3704, EG:BACR7A4.17, XAB1 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010139 31043 CG3704 http://www.ncbi.nlm.nih.gov/gene/?term=31043 "Dmel_ Dmel\CG3704, EG:BACR7A4.17, XAB1 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010140 31055 CG14629 http://www.ncbi.nlm.nih.gov/gene/?term=31055 "Dmel_ Dmel\CG14629, EG:103E12.2 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010141 3105 HLA-A http://www.ncbi.nlm.nih.gov/gene/?term=3105 HLAA mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010142 3105 HLA-A http://www.ncbi.nlm.nih.gov/gene/?term=3105 "Aw-33, Aw-74, HLAA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010143 3105 HLA-A http://www.ncbi.nlm.nih.gov/gene/?term=3105 "Aw-33, Aw-74, HLAA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010144 31065 CG11380 http://www.ncbi.nlm.nih.gov/gene/?term=31065 "Dmel_ Dmel\CG11380, EG:BACR42I17.7 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010145 31065 CG11380 http://www.ncbi.nlm.nih.gov/gene/?term=31065 "Dmel_ Dmel\CG11380, EG:BACR42I17.7 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010146 3106 HLA-B http://www.ncbi.nlm.nih.gov/gene/?term=3106 "AS, Bw-47, Bw-50, HLAB, SPDA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010147 3106 HLA-B http://www.ncbi.nlm.nih.gov/gene/?term=3106 "AS, Bw-47, Bw-50, HLAB, SPDA1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010148 31072 CG11403 http://www.ncbi.nlm.nih.gov/gene/?term=31072 "Dmel_ Dmel\CG11403, EG:33C11.2, cg11403 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010149 3107 HLA-C http://www.ncbi.nlm.nih.gov/gene/?term=3107 "D6S204, HLA-JY3, HLC-C, PSORS1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010150 3107 HLA-C http://www.ncbi.nlm.nih.gov/gene/?term=3107 "D6S204, HLA-JY3, HLAC, HLC-C, PSORS1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010151 31085 CG14770 http://www.ncbi.nlm.nih.gov/gene/?term=31085 Dmel_ Dmel\CG14770 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010152 310 ANXA7 http://www.ncbi.nlm.nih.gov/gene/?term=310 "ANX7, SNX, SYNEXIN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010153 310 ANXA7 http://www.ncbi.nlm.nih.gov/gene/?term=310 "ANX7, SNX, SYNEXIN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010154 31102 CG14780 http://www.ncbi.nlm.nih.gov/gene/?term=31102 "Dmel_ Dmel\CG14780, EG:80H7.3, SP95 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010155 31104 mei-38 http://www.ncbi.nlm.nih.gov/gene/?term=31104 "Dmel_CG14781, CG14781, D-TPX2, Dmel\CG14781, EG:80H7.11, Mei-38, Ssp1, ssp1 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010156 31115 CG11509 http://www.ncbi.nlm.nih.gov/gene/?term=31115 Dmel_ Dmel\CG11509 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010157 3111 HLA-DOA http://www.ncbi.nlm.nih.gov/gene/?term=3111 "HLA-DNA, HLA-DZA, HLADZ " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010158 3111 HLA-DOA http://www.ncbi.nlm.nih.gov/gene/?term=3111 "HLA-DNA, HLA-DZA, HLADZ " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010159 31136 CG42666 http://www.ncbi.nlm.nih.gov/gene/?term=31136 "Dmel_ CG14799, CG14800, CG14801, CG17968, Dmel\CG42666, Dmel_CG14799, Dmel_CG14801, EG:131F2.2, EG:137E7.1 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010160 31139 CG14814 http://www.ncbi.nlm.nih.gov/gene/?term=31139 "Dmel_ Dmel\CG14814, EG:63B12.6 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010161 3113 HLA-DPA1 http://www.ncbi.nlm.nih.gov/gene/?term=3113 "DP(W3), DP(W4), HLA-DP1A, HLADP, HLASB, PLT1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010162 31166 Actn http://www.ncbi.nlm.nih.gov/gene/?term=31166 "Dmel_CG4376, ACTN, CG4376, CT14163, CT14232, Dmel\CG4376, EG:133E12.1, GA17, HM-29, actn, alpha-actinin, alphaActn, fliA, l(1)2Cb, l(1)EA82, y " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010163 31173 CG4194 http://www.ncbi.nlm.nih.gov/gene/?term=31173 "Dmel_ Dmel\CG4194, EG:22E5.6 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010164 31179 Unc-76 http://www.ncbi.nlm.nih.gov/gene/?term=31179 "Dmel_CG3981, BcDNA:GH10260, CG18851, CG3981, Dmel\CG3981, Dunc-76, EG:67A9.1, UNC-76, l(1)G0066, l(1)G0158, l(1)G0310, l(1)G0333, l(1)G0360, unc-76 " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010165 31198 Mct1 http://www.ncbi.nlm.nih.gov/gene/?term=31198 "Dmel_CG3456, CG3456, Dmel\CG3456, EG:103B4.3 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010166 3119 HLA-DQB1 http://www.ncbi.nlm.nih.gov/gene/?term=3119 "CELIAC1, HLA-DQB, IDDM1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010167 311 ANXA11 http://www.ncbi.nlm.nih.gov/gene/?term=311 "ANX11, CAP50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010168 311 ANXA11 http://www.ncbi.nlm.nih.gov/gene/?term=311 "ANX11, CAP50 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010169 311 ANXA11 http://www.ncbi.nlm.nih.gov/gene/?term=311 "ANX11, CAP50 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010170 31221 Raf http://www.ncbi.nlm.nih.gov/gene/?term=31221 "Dmel_CG2845, 11-29, C110, CG2845, D-RAF, D-Raf, D-raf, D-raf1, DRaf, DRaf1, Dmel\CG2845, Draf, Draf-1, Draf1, EG:BACH48C10.3, Phl, RAF/phl, Raf1, dRaf, draf, l(1)2Fe, l(1)G0475, l(1)ph, l(1)phl, l(1)pole hole, l(1)polehole, l(1)polehole/draf, l(1)raf, lincRNA.937, ph, ph1, phl, raf, raf-1, raf1, rafl, Raf " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010171 3122 HLA-DRA http://www.ncbi.nlm.nih.gov/gene/?term=3122 "HLA-DRA1, MLRW " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010172 3123 HLA-DRB1 http://www.ncbi.nlm.nih.gov/gene/?term=3123 "DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010173 31284 CG14420 http://www.ncbi.nlm.nih.gov/gene/?term=31284 Dmel_ Dmel\CG14420 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010174 31287 CG14423 http://www.ncbi.nlm.nih.gov/gene/?term=31287 Dmel_ Dmel\CG14423 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010175 31289 CG3603 http://www.ncbi.nlm.nih.gov/gene/?term=31289 "Dmel_ BcDNA:RH09070, Dmel\CG3603 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010176 31295 CG3939 http://www.ncbi.nlm.nih.gov/gene/?term=31295 "Dmel_ BEST:SD07039, Dmel\CG3939, EG:140G11.5 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010177 31309 dnc http://www.ncbi.nlm.nih.gov/gene/?term=31309 "Dmel_CG32498, CG10791, CG10792, CG10797, CG14267, CG14268, CG32498, Dmel\CG32498, EG:140G11.4, EG:96G10.7, EG:BACN05I09.3, EG:BACN5I9.2, PDE4, PDEII, fs(1)M42 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010178 31310 Myc http://www.ncbi.nlm.nih.gov/gene/?term=31310 "Dmel_CG10798, CG10798, D- DM, DMYc, Dm, Dmel\CG10798, Dmyc, EG:BACN5I9.1, MYC, anon-WO03040301.171, bHLHe57, c-MYC, c-Myc, c-myc, d-myc, dMYC, dMyc, dMyc1, dm, dm/dMyc, dm/myc, dmyc, dmyc1, l(1)G0139, l(1)G0354, l(1)G0359, myc " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010179 31310 Myc http://www.ncbi.nlm.nih.gov/gene/?term=31310 "Dmel_CG10798, CG10798, D- DM, DMYc, Dm, Dmel\CG10798, Dmyc, EG:BACN5I9.1, MYC, anon-WO03040301.171, bHLHe57, c-MYC, c-Myc, c-myc, d-myc, dMYC, dMyc, dMyc1, dm, dm/dMyc, dm/myc, dmyc, dmyc1, l(1)G0139, l(1)G0354, l(1)G0359, myc " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010180 31310 Myc http://www.ncbi.nlm.nih.gov/gene/?term=31310 "Dmel_CG10798, CG10798, D- DM, DMYc, Dm, Dmel\CG10798, Dmyc, EG:BACN5I9.1, MYC, anon-WO03040301.171, bHLHe57, c-MYC, c-Myc, c-myc, d-myc, dMYC, dMyc, dMyc1, dm, dm/dMyc, dm/myc, dmyc, dmyc1, l(1)G0139, l(1)G0354, l(1)G0359, myc " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010181 31310 Myc http://www.ncbi.nlm.nih.gov/gene/?term=31310 "Dmel_CG10798, CG10798, D- DM, DMYc, Dm, Dmel\CG10798, Dmyc, EG:BACN5I9.1, MYC, anon-WO03040301.171, bHLHe57, c-MYC, c-Myc, c-myc, d-myc, dMYC, dMyc, dMyc1, dm, dm/dMyc, dm/myc, dmyc, dmyc1, l(1)G0139, l(1)G0354, l(1)G0359, myc " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010182 31310 Myc http://www.ncbi.nlm.nih.gov/gene/?term=31310 "Dmel_CG10798, CG10798, D- DM, DMYc, Dm, Dmel\CG10798, Dmyc, EG:BACN5I9.1, MYC, anon-WO03040301.171, bHLHe57, c-MYC, c-Myc, c-myc, d-myc, dMYC, dMyc, dMyc1, dm, dm/dMyc, dm/myc, dmyc, dmyc1, l(1)G0139, l(1)G0354, l(1)G0359, myc " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010183 31318 CG10802 http://www.ncbi.nlm.nih.gov/gene/?term=31318 "Dmel_ Dmel\CG10802, anon-EST:Posey113 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010184 31320 CG10803 http://www.ncbi.nlm.nih.gov/gene/?term=31320 Dmel_ Dmel\CG10803 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010185 31322 DIP-alpha http://www.ncbi.nlm.nih.gov/gene/?term=31322 "Dmel_CG32791, 32791, CG13019, CG13020, CG32791, Dmel\CG32791 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010186 3133 HLA-E http://www.ncbi.nlm.nih.gov/gene/?term=3133 "EA1.2, EA2.1, HLA-6.2, MHC, QA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010187 3133 HLA-E http://www.ncbi.nlm.nih.gov/gene/?term=3133 "EA1.2, EA2.1, HLA-6.2, MHC, QA1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010188 31348 CG2941 http://www.ncbi.nlm.nih.gov/gene/?term=31348 Dmel_ Dmel\CG2941 mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010189 31348 CG2941 http://www.ncbi.nlm.nih.gov/gene/?term=31348 Dmel_ Dmel\CG2941 mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010190 3134 HLA-F http://www.ncbi.nlm.nih.gov/gene/?term=3134 "CDA12, HLA-5.4, HLA-CDA12, HLAF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010191 3136 HLA-H http://www.ncbi.nlm.nih.gov/gene/?term=3136 HLAHP lncRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010192 31381 rb http://www.ncbi.nlm.nih.gov/gene/?term=31381 "Dmel_CG11427, AP-3beta, CG11427, Dmel\CG11427, Rb, apl6, beta3, cg11427 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010193 31384 Usf http://www.ncbi.nlm.nih.gov/gene/?term=31384 "Dmel_CG17592, CG17592, Dm DmUsf, Dmel\CG17592, bHLHb13, dUSF, dUSF2 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010194 31384 Usf http://www.ncbi.nlm.nih.gov/gene/?term=31384 "Dmel_CG17592, CG17592, Dm DmUsf, Dmel\CG17592, bHLHb13, dUSF, dUSF2 " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010195 31386 CG11436 http://www.ncbi.nlm.nih.gov/gene/?term=31386 Dmel_ Dmel\CG11436 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010196 31388 CG11444 http://www.ncbi.nlm.nih.gov/gene/?term=31388 Dmel_ Dmel\CG11444 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010197 3140 MR1 http://www.ncbi.nlm.nih.gov/gene/?term=3140 HLALS mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010198 3141 HLCS http://www.ncbi.nlm.nih.gov/gene/?term=3141 HCS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010199 3141 HLCS http://www.ncbi.nlm.nih.gov/gene/?term=3141 HCS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010200 3141 HLCS http://www.ncbi.nlm.nih.gov/gene/?term=3141 HCS mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010201 31426 CG15468 http://www.ncbi.nlm.nih.gov/gene/?term=31426 "Dmel_ Dmel\CG15468, SIP3 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010202 31429 ovo http://www.ncbi.nlm.nih.gov/gene/?term=31429 "Dmel_CG6824, CG15467, CG6824, Dmel\CG6824, Fs(1)K1103, Fs(1)K1237, Fs(1)K155, OVO, Ovo, Ovo-D, Shv, Svb, Svb/Ovo, fs(1)K1237, fs(1)M1, fs(1)M38/shavenbaby, ovo/svb, ovoD, svb " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00010203 314310 Zfp410 http://www.ncbi.nlm.nih.gov/gene/?term=314310 Znf410 mRNA Rattus norvegicus 25301173 Dendrite Hippocampus In situ hybridization "Probes against ZFP410, COMMD3 and RSP6 transcripts show higher dendritic localization in rat neurons than in mouse neurons (Blue box). Probes Zfp410, Commd3, and Rps6 showed lower dendrite soma ratios for mouse vs rat at 0.085 vs 0.174 (p < 0.09), 0.101 vs 0.215 (p < 0.001), and 0.034 vs 0.097 (p < 0.008), respectively. " RLID00010204 31444 dhd http://www.ncbi.nlm.nih.gov/gene/?term=31444 "Dmel_CG4193, 4193, CG4193, Dhd, DmTrx-1, Dmdhd, Dmel\CG4193, Dmeldhd, Trx-1 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010205 31448 Rnp4F http://www.ncbi.nlm.nih.gov/gene/?term=31448 "Dmel_CG3312, 4F-rnp, 4f-rnp, CG3312, Dmel\CG3312, RNP-4F, Rnp-4F, rnp-4f " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010206 31459 spoon http://www.ncbi.nlm.nih.gov/gene/?term=31459 "Dmel_CG3249, BcDNA:GM04319, CG3249, DAKAP550, Dmel\CG3249, PKAAP, Yu, yu " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010207 31459 spoon http://www.ncbi.nlm.nih.gov/gene/?term=31459 "Dmel_CG3249, BcDNA:GM04319, CG3249, DAKAP550, Dmel\CG3249, PKAAP, Yu, yu " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010208 3145 HMBS http://www.ncbi.nlm.nih.gov/gene/?term=3145 "PBG-D, PBGD, PORC, UPS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010209 3145 HMBS http://www.ncbi.nlm.nih.gov/gene/3145 "UPS, PBGD, PORC, PBG-D " mRNA Homo sapiens 19175411 Ribosome T-cell|SeAx qRT-PCR "Using quantitative real-time RT-PCR we evaluated, whether mRNAs coding for differently located proteins are selectively enriched in one of the two analysed compartments, namely free versus membrane-associated polysomes. We selected genes coding for proteins located in the plasma membrane (GPR137B), secreted proteins (TIC2, IBP2, PAI) and cytosolic proteins (the house keeping genes GAPDH and HMBS). In fact, the distribution of the specific mRNA was as predicted ( Fig. 1): The average ratio of specific mRNA at bound ribosomes versus free ribosomes was 1 ? 4.4 for the housekeeping genes (GAPDH and HMBS) and 13.3 ? 1 for genes coding for membrane-bound or secreted proteins. Ratios for genes coding for cytosolic proteins were always below 0.6 and those for membrane or secreted genes were always above 1. The highest values were observed for PAI in MyLa (57 ? 1) and GPR137B in SeAx (34 ? 1), while the lowest ratios were detected for HMBS (1 ? 55) and GAPDH (1 ? 12) in HuT78. " RLID00010210 3145 HMBS http://www.ncbi.nlm.nih.gov/gene/?term=3145 "PBG-D, PBGD, PORC, UPS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010211 3146 HMGB1 http://www.ncbi.nlm.nih.gov/gene/?term=3146 "HMG-1, HMG1, HMG3, SBP-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010212 3146 HMGB1 http://www.ncbi.nlm.nih.gov/gene/?term=3146 "HMG-1, HMG1, HMG3, SBP-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010213 3148 HMGB2 http://www.ncbi.nlm.nih.gov/gene/?term=3148 HMG2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010214 31491 CG33080 http://www.ncbi.nlm.nih.gov/gene/?term=31491 "Dmel_ CG15774, CG15775, CG3141, Dmel\CG33080 " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010215 31498 CG15772 http://www.ncbi.nlm.nih.gov/gene/?term=31498 Dmel_ Dmel\CG15772 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010216 3149 HMGB3 http://www.ncbi.nlm.nih.gov/gene/?term=3149 "HMG-2a, HMG-4, HMG2A, HMG4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010217 3150 HMGN1 http://www.ncbi.nlm.nih.gov/gene/?term=3150 HMG14 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010218 31513 CG15765 http://www.ncbi.nlm.nih.gov/gene/?term=31513 Dmel_ Dmel\CG15765 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010219 3151 HMGN2 http://www.ncbi.nlm.nih.gov/gene/?term=3151 HMG17 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010220 3151 HMGN2 http://www.ncbi.nlm.nih.gov/gene/?term=3151 HMG17 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010221 3151 HMGN2 http://www.ncbi.nlm.nih.gov/gene/?term=3151 HMG17 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010222 3155 HMGCL http://www.ncbi.nlm.nih.gov/gene/?term=3155 HL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010223 3155 HMGCL http://www.ncbi.nlm.nih.gov/gene/?term=3155 HL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010224 3156 HMGCR http://www.ncbi.nlm.nih.gov/gene/?term=3156 LDLCQ3 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010225 3156 HMGCR http://www.ncbi.nlm.nih.gov/gene/?term=3156 LDLCQ3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010226 3157 HMGCS1 http://www.ncbi.nlm.nih.gov/gene/?term=3157 HMGCS mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010227 3157 HMGCS1 http://www.ncbi.nlm.nih.gov/gene/?term=3157 HMGCS mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010228 31585 CG3918 http://www.ncbi.nlm.nih.gov/gene/?term=31585 Dmel_ Dmel\CG3918 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010229 3158 HMGCS2 http://www.ncbi.nlm.nih.gov/gene/?term=3158 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010230 3159 HMGA1 http://www.ncbi.nlm.nih.gov/gene/?term=3159 "HMG-R, HMGA1A, HMGIY " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010231 3159 HMGA1 http://www.ncbi.nlm.nih.gov/gene/?term=3159 "HMG-RA, HMGIY, HMGA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010232 31602 CG3198 http://www.ncbi.nlm.nih.gov/gene/?term=31602 Dmel_ Dmel\CG3198 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010233 31617 shf http://www.ncbi.nlm.nih.gov/gene/?term=31617 "Dmel_CG3135, CG3134, CG3135, CT10514, D-Wif, DmWIF, DmWif, Dmel\CG3135, Shf-ov, shf " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010234 31618 C3G http://www.ncbi.nlm.nih.gov/gene/?term=31618 "Dmel_CG42328, C(3)G, CG14436, CG3126, CG42328, DC3-G, DC3G, Dmel\CG42328, Dmel_CG14436, Dmel_CG3126, c(3)G " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010235 3161 HMMR http://www.ncbi.nlm.nih.gov/gene/?term=3161 "CD168, IHABP, RHAMM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010236 3161 HMMR http://www.ncbi.nlm.nih.gov/gene/?term=3161 "CD168, IHABP, RHAMM " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010237 3161 HMMR http://www.ncbi.nlm.nih.gov/gene/?term=3161 "CD168, IHABP, RHAMM " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010238 31628 CG14435 http://www.ncbi.nlm.nih.gov/gene/?term=31628 Dmel_ Dmel\CG14435 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010239 3163 HMOX2 http://www.ncbi.nlm.nih.gov/gene/?term=3163 HO-2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010240 3163 HMOX2 http://www.ncbi.nlm.nih.gov/gene/?term=3163 HO-2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010241 31646 Inx2 http://www.ncbi.nlm.nih.gov/gene/?term=31646 "Dmel_CG4590, CG4590, D-inx-2, Dm-inx, Dm-inx2, Dmel\CG4590, FBpp0291074, INX-2, Ix2, inx-2, inx2, kropf, l(1)G0035, l(1)G0036, l(1)G0043, l(1)G0059, l(1)G0118, l(1)G0157, l(1)G0317, l(1)G0364, prp33 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010242 3164 NR4A1 http://www.ncbi.nlm.nih.gov/gene/?term=3164 "GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010243 31651 CG14427 http://www.ncbi.nlm.nih.gov/gene/?term=31651 Dmel_ Dmel\CG14427 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010244 31658 CG8300 http://www.ncbi.nlm.nih.gov/gene/?term=31658 Dmel_ Dmel\CG8300 mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010245 31658 CG8300 http://www.ncbi.nlm.nih.gov/gene/?term=31658 Dmel_ Dmel\CG8300 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010246 31665 brk http://www.ncbi.nlm.nih.gov/gene/?term=31665 "Dmel_CG9653, Brk, CG9653, Dm brk, Dmel\CG9653, ssg-1 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010247 31665 brk http://www.ncbi.nlm.nih.gov/gene/?term=31665 "Dmel_CG9653, Brk, CG9653, Dm brk, Dmel\CG9653, ssg-1 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010248 31667 Dok http://www.ncbi.nlm.nih.gov/gene/?term=31667 "Dmel_CG2079, CG2079, Ddok, Dmel\CG2079, l(1)G0331 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010249 31667 Dok http://www.ncbi.nlm.nih.gov/gene/?term=31667 "Dmel_CG2079, CG2079, Ddok, Dmel\CG2079, l(1)G0331 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010250 31667 Dok http://www.ncbi.nlm.nih.gov/gene/?term=31667 "Dmel_CG2079, CG2079, Ddok, Dmel\CG2079, l(1)G0331 " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010251 31667 Dok http://www.ncbi.nlm.nih.gov/gene/?term=31667 "Dmel_CG2079, CG2079, Ddok, Dmel\CG2079, l(1)G0331 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010252 31696 Nek2 http://www.ncbi.nlm.nih.gov/gene/?term=31696 "Dmel_CG17256, CG17256, Dm DmNek2, Dmel\CG17256, NEK2, dNek2 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010253 316 AOX1 http://www.ncbi.nlm.nih.gov/gene/?term=316 "AO, AOH1 " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00010254 31704 snz http://www.ncbi.nlm.nih.gov/gene/?term=31704 "Dmel_CG1514, CG1514, DmSNX25, Dmel\CG1514, Snz " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010255 31704 snz http://www.ncbi.nlm.nih.gov/gene/?term=31704 "Dmel_CG1514, CG1514, DmSNX25, Dmel\CG1514, Snz " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010256 31712 l(1)G0193 http://www.ncbi.nlm.nih.gov/gene/?term=31712 "Dmel_CG2206, CG2206, Dmel\CG2206, l(1)G0327 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010257 31717 sn http://www.ncbi.nlm.nih.gov/gene/?term=31717 "Dmel_CG32858, CG15331, CG1536, CG32858, Dmel\CG32858, SN, Sn, fs(1)A1057, fs(1)K1421, fs(1)K418, fs(1)K473, fs(1)K743, fs(1)M45 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010258 31717 sn http://www.ncbi.nlm.nih.gov/gene/?term=31717 "Dmel_CG32858, CG15331, CG1536, CG32858, Dmel\CG32858, SN, Sn, fs(1)A1057, fs(1)K1421, fs(1)K418, fs(1)K473, fs(1)K743, fs(1)M45 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010259 31717 sn http://www.ncbi.nlm.nih.gov/gene/?term=31717 "Dmel_CG32858, CG15331, CG1536, CG32858, Dmel\CG32858, SN, Sn, fs(1)A1057, fs(1)K1421, fs(1)K418, fs(1)K473, fs(1)K743, fs(1)M45 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010260 3171 FOXA3 http://www.ncbi.nlm.nih.gov/gene/?term=3171 "FKHH3, HNF3G, TCF3G " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010261 3172 HNF4A http://www.ncbi.nlm.nih.gov/gene/?term=3172 "FRTS4, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010262 31733 cyr http://www.ncbi.nlm.nih.gov/gene/?term=31733 "Dmel_CG15335, CG15335, CG15338, Dmel\CG15335 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010263 31738 Smox http://www.ncbi.nlm.nih.gov/gene/?term=31738 "Dmel_CG2262, CG2262, DSMAD2, DSmad2, Dmel\CG2262, SMAD2, SMOX, Sad, Smad, Smad2, SmoX, dSMAD2, dSmad2, dsmad2, l(1)G0348, sad, smad2, smox, ted, tmp " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00010264 31744 Gbeta5 http://www.ncbi.nlm.nih.gov/gene/?term=31744 "Dmel_CG10763, CG10763, Dmel\CG10763, G[[beta5]], G[[beta]], Gbeta, Gbeta 5, Gbetagamma " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010265 317646 Rpl13a http://www.ncbi.nlm.nih.gov/gene/?term=317646 snoRNA Rattus norvegicus 25792744 Nucleus Myocardium Next-generation sequencing|qRT-PCR "Our data showing that 99% of Rpl13a snoRNAs are nuclear in unstressed cells are consistent with this (Fig. 1F). However, by using the high sensitivity methods of qPCR and RNA-seq, we show for the first time that a broad range of snoRNAs are easily detectable in the cytoplasm. The accumulation of Rpl13a snoRNAs in the cytoplasm after oxidative stress is rapid and significant. " RLID00010266 317646 Rpl13a http://www.ncbi.nlm.nih.gov/gene/?term=317646 snoRNA Rattus norvegicus 25792744 Cytoplasm Myocardium Next-generation sequencing|qRT-PCR "Our data showing that 99% of Rpl13a snoRNAs are nuclear in unstressed cells are consistent with this (Fig. 1F). However, by using the high sensitivity methods of qPCR and RNA-seq, we show for the first time that a broad range of snoRNAs are easily detectable in the cytoplasm. The accumulation of Rpl13a snoRNAs in the cytoplasm after oxidative stress is rapid and significant. " RLID00010267 317648 NOP14-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=317648 "C4orf10, RES4-24 " lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010268 317662 FAM149B1 http://www.ncbi.nlm.nih.gov/gene/?term=317662 KIAA0974 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010269 3176 HNMT http://www.ncbi.nlm.nih.gov/gene/?term=3176 "HMT, HNMT-S1, HNMT-S2, MRT51 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010270 3176 HNMT http://www.ncbi.nlm.nih.gov/gene/?term=3176 "HMT-S1, HNMT-S2, MRT51, HNMT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010271 31773 Trf2 http://www.ncbi.nlm.nih.gov/gene/?term=31773 "Dmel_CG18009, CG11195, CG18009, Dmel\CG18009, TLF, TRF2, dTRF2, dTRF2L, dTRF2S, dTrf2, l(1)G0039, l(1)G0071, l(1)G0295, l(1)G0425, p79/TRF2, trf2 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00010272 317758 Gimap9 http://www.ncbi.nlm.nih.gov/gene/?term=317758 "A630002K24, BB145400 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010273 31775 CG12125 http://www.ncbi.nlm.nih.gov/gene/?term=31775 Dmel_ Dmel\CG12125 mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010274 317762 CCDC85C http://www.ncbi.nlm.nih.gov/gene/?term=317762 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010275 317772 HIST2H2AB http://www.ncbi.nlm.nih.gov/gene/?term=317772 H2AB mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010276 317781 DDX51 http://www.ncbi.nlm.nih.gov/gene/?term=317781 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010277 3177 SLC29A2 http://www.ncbi.nlm.nih.gov/gene/?term=3177 "DER12, ENT2, HNP36 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010278 317824 Zyx http://www.ncbi.nlm.nih.gov/gene/?term=317824 "Dmel_CG32018, BcDNA:LD06023, CG32018, DLim-1, DmLIM-1, Dmel\CG32018, Lim102EF, ZYX102102, Zyx102EF, lim, zyx, zyx102, zyxin, Zyx " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00010279 317824 Zyx http://www.ncbi.nlm.nih.gov/gene/?term=317824 "Dmel_CG32018, BcDNA:LD06023, CG32018, DLim-1, DmLIM-1, Dmel\CG32018, Lim102EF, ZYX102102, Zyx102EF, lim, zyx, zyx102, zyxin, Zyx " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010280 317829 CG32026 http://www.ncbi.nlm.nih.gov/gene/?term=317829 "Dmel_ BcDNA:GH12815, Dmel\CG32026, anon-WO0140519.202 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010281 317894 CG32170 http://www.ncbi.nlm.nih.gov/gene/?term=317894 "Dmel_ BcDNA:RE28470, CT12913, Dmel\CG32170 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010282 317894 CG32170 http://www.ncbi.nlm.nih.gov/gene/?term=317894 "Dmel_ BcDNA:RE28470, CT12913, Dmel\CG32170 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010283 3178 HNRNPA1 http://www.ncbi.nlm.nih.gov/gene/?term=3178 "ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, UP 1, hnRNP A1, hnRNP-A1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010284 3178 HNRNPA1 http://www.ncbi.nlm.nih.gov/gene/?term=3178 "ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, UP 1, hnRNP A1, hnRNP-A1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010285 3178 HNRNPA1 http://www.ncbi.nlm.nih.gov/gene/?term=3178 "ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, UP 1, hnRNP A1, hnRNP-A1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010286 317 APAF1 http://www.ncbi.nlm.nih.gov/gene/?term=317 "APAF-1, CED4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010287 317 APAF1 http://www.ncbi.nlm.nih.gov/gene/?term=317 "APAF-1, CED4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010288 318000 CG32373 http://www.ncbi.nlm.nih.gov/gene/?term=318000 "Dmel_ BcDNA:RE64043, CG3237, Dmel\CG32373 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010289 318000 CG32373 http://www.ncbi.nlm.nih.gov/gene/?term=318000 "Dmel_ BcDNA:RE64043, CG3237, Dmel\CG32373 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010290 31808 Hexo2 http://www.ncbi.nlm.nih.gov/gene/?term=31808 "Dmel_CG1787, CG1787, DmHex2, Dmel\CG1787, HEX 2, HEX2, HEXO2 " mRNA Drosophila melanogaster 25838129 Basal Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010291 31813 Lim1 http://www.ncbi.nlm.nih.gov/gene/?term=31813 "Dmel_CG11354, BcDNA:GH04929, CG10760, CG11354, Dlim1, Dmel\CG11354, Lim, d dlim-1, dlim1, lim1 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010292 31813 Lim1 http://www.ncbi.nlm.nih.gov/gene/?term=31813 "Dmel_CG11354, BcDNA:GH04929, CG10760, CG11354, Dlim1, Dmel\CG11354, Lim, d dlim-1, dlim1, lim1 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010293 31816 Moe http://www.ncbi.nlm.nih.gov/gene/?term=31816 "Dmel_CG10701, CG10701, D17, Dmel\CG10701, Dmoe, EMR1, ERM, Emr1s, anon-WO03040301.155, anon-WO03040301.157, anon-WO03040301.159, anon-WO03040301.161, dMoe, gma, l(1)G0067, l(1)G0323, l(1)G0404, l(1)G0415, moe, moesin/ezrin/radixin homolog mRNA, Moe " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010294 3181 HNRNPA2B1 http://www.ncbi.nlm.nih.gov/gene/?term=3181 "HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2, RNPA2, SNRPB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010295 3181 HNRNPA2B1 http://www.ncbi.nlm.nih.gov/gene/?term=3181 "HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2, RNPA2, SNRPB1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010296 3181 HNRNPA2B1 http://www.ncbi.nlm.nih.gov/gene/?term=3181 "HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2, RNPA2, SNRPB1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010297 31824 CG10962 http://www.ncbi.nlm.nih.gov/gene/?term=31824 "Dmel_ BcDNA:RE29909, CG7090, Dmel\CG10962, EP(X)1565, EP1565 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010298 3182 HNRNPAB http://www.ncbi.nlm.nih.gov/gene/?term=3182 "ABBP1, HNRPAB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010299 3182 HNRNPAB http://www.ncbi.nlm.nih.gov/gene/?term=3182 "ABBP1, HNRPAB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010300 3182 HNRNPAB http://www.ncbi.nlm.nih.gov/gene/?term=3182 "ABBP1, HNRPAB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010301 31833 CG7246 http://www.ncbi.nlm.nih.gov/gene/?term=31833 "Dmel_ Dmel\CG7246, dUTP6 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010302 31833 CG7246 http://www.ncbi.nlm.nih.gov/gene/?term=31833 "Dmel_ Dmel\CG7246, dUTP6 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010303 3183 HNRNPC http://www.ncbi.nlm.nih.gov/gene/?term=3183 "C1, C2, HNRNP, HNRPC, SNRPC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010304 3183 HNRNPC http://www.ncbi.nlm.nih.gov/gene/?term=3183 "C1, C2, HNRNP, HNRPC, SNRPC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010305 3183 HNRNPC http://www.ncbi.nlm.nih.gov/gene/?term=3183 "C1, C2, HNRNP, HNRPC, SNRPC " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010306 318566 CG34133 http://www.ncbi.nlm.nih.gov/gene/?term=318566 "Dmel_ CG31035, CG7814, Dmel\CG34133, anon-WO0118547.417 " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010307 3185 HNRNPF http://www.ncbi.nlm.nih.gov/gene/?term=3185 "HNRPF, OK/SW-cl.23, mcs94-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010308 3185 HNRNPF http://www.ncbi.nlm.nih.gov/gene/?term=3185 "HNRPF, OK/SW-cl.23, mcs94-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010309 3185 HNRNPF http://www.ncbi.nlm.nih.gov/gene/?term=3185 "HNRPF, OK/SW-cl.23, mcs94-1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010310 3187 HNRNPH1 http://www.ncbi.nlm.nih.gov/gene/?term=3187 "HNRPH, HNRPH1, hnRNPH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010311 3187 HNRNPH1 http://www.ncbi.nlm.nih.gov/gene/?term=3187 "HNRPH, HNRPH1, hnRNPH " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010312 318841 Bsg http://www.ncbi.nlm.nih.gov/gene/?term=318841 "Dmel_CG31605, 135/10, BcDNA:GH21853, CG31605, Dmel\CG31605, NP6293, bsg, gel, l(2)06243, l(2)SH1217, l(2)SH2 1217, l(2)k06338, l(2)k09030, l(2)k13638, l(2)k14308, ms(2)08318 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010313 3188 HNRNPH2 http://www.ncbi.nlm.nih.gov/gene/?term=3188 "FTP3, HNRPH', HNRPH2, hnRNPH' " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010314 3188 HNRNPH2 http://www.ncbi.nlm.nih.gov/gene/?term=3188 "FTP3, HNRPH', HNRPH2, hnRNPH' " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010315 3189 HNRNPH3 http://www.ncbi.nlm.nih.gov/gene/?term=3189 "2H9, HNRPH3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010316 318 NUDT2 http://www.ncbi.nlm.nih.gov/gene/?term=318 APAH1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010317 3190 HNRNPK http://www.ncbi.nlm.nih.gov/gene/?term=3190 "AUKS, CSBP, HNRPK, TUNP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010318 3190 HNRNPK http://www.ncbi.nlm.nih.gov/gene/?term=3190 "AUKS, CSBP, HNRPK, TUNP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010319 3190 HNRNPK http://www.ncbi.nlm.nih.gov/gene/?term=3190 "AUKS, CSBP, HNRPK, TUNP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010320 319103 SNORD8 http://www.ncbi.nlm.nih.gov/gene/?term=319103 "RNU6C, mgU6-53 " snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010321 319103 SNORD8 http://www.ncbi.nlm.nih.gov/gene/?term=319103 "RNU6C, mgU6-53 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00010322 319146 Ifnz http://www.ncbi.nlm.nih.gov/gene/?term=319146 "6030405N23Rik, BGIF, ENSMUSG00000073810, Lmtn " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010323 319172 Hist1h2ab http://www.ncbi.nlm.nih.gov/gene/?term=319172 "H2A.1, H2a-53 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010324 319178 Hist1h2bb http://www.ncbi.nlm.nih.gov/gene/?term=319178 H2b-143 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010325 319181 Hist1h2bg http://www.ncbi.nlm.nih.gov/gene/?term=319181 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010326 319190 Hist2h2be http://www.ncbi.nlm.nih.gov/gene/?term=319190 "AV127319, H2b-613, T25626 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010327 319195 Rpl17 http://www.ncbi.nlm.nih.gov/gene/?term=319195 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010328 319195 Rpl17 http://www.ncbi.nlm.nih.gov/gene/?term=319195 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00010329 3191 HNRNPL http://www.ncbi.nlm.nih.gov/gene/?term=3191 "HNRPL, P/OKcl.14, hnRNP-L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010330 319211 Nol4 http://www.ncbi.nlm.nih.gov/gene/?term=319211 "1700013J13Rik, 4930568N03Rik, Gm1262 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010331 319243 9430062P05Rik http://www.ncbi.nlm.nih.gov/gene/?term=319243 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010332 319269 A130040M12Rik http://www.ncbi.nlm.nih.gov/gene/?term=319269 "CA782090, H3053C11, VL30 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010333 319269 A130040M12Rik http://www.ncbi.nlm.nih.gov/gene/?term=319269 "CA782090, H3053C11, VL30 " mRNA Mus musculus 16730676 Ribosome Brain In situ hybridization "These VL30 transcripts remained associated with polyribosomes in the presence of 0.5 M KCl, indicating that VL30 mRNA was tightly associated with ribosomal subunits. " RLID00010334 319269 A130040M12Rik http://www.ncbi.nlm.nih.gov/gene/?term=319269 "CA782090, H3053C11, VL30 " mRNA Mus musculus 25847616 Mitochondrion Liver Next-generation sequencing|qRT-PCR "Several nuclear transcribed RNAs were found within mitochondrial RNA (mtRNA) samples, including nuclear ribosomal RNAs, gamma satellite RNA and VL30 retroelement RNA. Additionally, our improved mitochondrial localization interrogation technique supported the localization of VL30 retroelement RNA within mitochondria. Maintenance of VL30 RNA was observed until mitochondrial rupture, where it was destroyed by nuclease activity. " RLID00010335 3192 HNRNPU http://www.ncbi.nlm.nih.gov/gene/?term=3192 "HNRNPU-AS1, HNRPU, SAF-A, SAFA, U21.1, hnRNP U " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010336 3192 HNRNPU http://www.ncbi.nlm.nih.gov/gene/?term=3192 "HNRNPU-AS1, HNRPU, SAF-A, SAFA, U21.1, hnRNP U " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010337 319301 A730027B03Rik http://www.ncbi.nlm.nih.gov/gene/?term=319301 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010338 319352 Pianp http://www.ncbi.nlm.nih.gov/gene/?term=319352 "AI255183, AU067746, C530028O21Rik, Panp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010339 319377 D130012P04Rik http://www.ncbi.nlm.nih.gov/gene/?term=319377 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010340 319430 C5ar2 http://www.ncbi.nlm.nih.gov/gene/?term=319430 "C5L2, E030029A11Rik, Gpr77 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010341 319448 Fndc3a http://www.ncbi.nlm.nih.gov/gene/?term=319448 "1700094E19Rik, D14Ertd453e, F730017H24Rik, Fndc3, sys " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010342 31945 RhoU http://www.ncbi.nlm.nih.gov/gene/?term=31945 "Dmel_CG34104, CG12094, CG12102, CG34104, Dmel\CG34104 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010343 31945 RhoU http://www.ncbi.nlm.nih.gov/gene/?term=31945 "Dmel_CG34104, CG12094, CG12102, CG34104, Dmel\CG34104 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010344 31945 RhoU http://www.ncbi.nlm.nih.gov/gene/?term=31945 "Dmel_CG34104, CG12094, CG12102, CG34104, Dmel\CG34104 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010345 319460 A130094D17Rik http://www.ncbi.nlm.nih.gov/gene/?term=319460 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010346 319475 Zfp672 http://www.ncbi.nlm.nih.gov/gene/?term=319475 "4930488P06Rik, 4930511N19Rik, Znf672 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010347 31949 CG15309 http://www.ncbi.nlm.nih.gov/gene/?term=31949 "Dmel_ BcDNA:GH10478, Dmel\CG15309 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010348 319552 Spx http://www.ncbi.nlm.nih.gov/gene/?term=319552 "B230216G23Rik, Npq " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010349 319556 A330041J22Rik http://www.ncbi.nlm.nih.gov/gene/?term=319556 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010350 319560 9630002D21Rik http://www.ncbi.nlm.nih.gov/gene/?term=319560 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010351 319564 C230012O17Rik http://www.ncbi.nlm.nih.gov/gene/?term=319564 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010352 319583 Lig4 http://www.ncbi.nlm.nih.gov/gene/?term=319583 "5830471N16Rik, tiny " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010353 319604 Fam168a http://www.ncbi.nlm.nih.gov/gene/?term=319604 "2610030B18Rik, B930006L02Rik, mKIAA0280 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010354 319615 Zfp944 http://www.ncbi.nlm.nih.gov/gene/?term=319615 6330416L07Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010355 319626 9530059O14Rik http://www.ncbi.nlm.nih.gov/gene/?term=319626 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010356 319637 A430072C10Rik http://www.ncbi.nlm.nih.gov/gene/?term=319637 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010357 319651 Usp37 http://www.ncbi.nlm.nih.gov/gene/?term=319651 "4932415L06Rik, C330008N13Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010358 319664 E230012J19Rik http://www.ncbi.nlm.nih.gov/gene/?term=319664 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010359 319665 A430010J10Rik http://www.ncbi.nlm.nih.gov/gene/?term=319665 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010360 319670 Eml5 http://www.ncbi.nlm.nih.gov/gene/?term=319670 "BC027154, C130068M19Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010361 319675 Cep295 http://www.ncbi.nlm.nih.gov/gene/?term=319675 "5830418K08Rik, 5832426L23Rik, Gm1131, Kiaa1731 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010362 319675 Cep295 http://www.ncbi.nlm.nih.gov/gene/?term=319675 "5830418K08Rik, 5832426L23Rik, Gm1131, Kiaa1731 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010363 319710 Frmd6 http://www.ncbi.nlm.nih.gov/gene/?term=319710 "2610019M19Rik, 4930488L10Rik, AW212977, Willin " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010364 319719 Simc1 http://www.ncbi.nlm.nih.gov/gene/?term=319719 4732471D19Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010365 319739 B230303O12Rik http://www.ncbi.nlm.nih.gov/gene/?term=319739 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010366 319747 C130023A14Rik http://www.ncbi.nlm.nih.gov/gene/?term=319747 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010367 319758 Rfx7 http://www.ncbi.nlm.nih.gov/gene/?term=319758 "2510005N23Rik, 9930116O05Rik, D130086K05Rik, Rfxdc2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010368 319765 Igf2bp2 http://www.ncbi.nlm.nih.gov/gene/?term=319765 "C330012H03Rik, IMP-2, Imp2, Neilsen " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010369 319806 D630022N01Rik http://www.ncbi.nlm.nih.gov/gene/?term=319806 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010370 319807 Nwd2 http://www.ncbi.nlm.nih.gov/gene/?term=319807 "3110047P20Rik, B830017A01Rik, Hn1-ps2, mKIAA1239 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010371 319817 Rc3h2 http://www.ncbi.nlm.nih.gov/gene/?term=319817 "2900024N03Rik, 9430019J22Rik, D930043C02Rik, Mnab, Rnf164 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010372 319819 4932435O22Rik http://www.ncbi.nlm.nih.gov/gene/?term=319819 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010373 319829 9330154K18Rik http://www.ncbi.nlm.nih.gov/gene/?term=319829 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010374 31986 CG15296 http://www.ncbi.nlm.nih.gov/gene/?term=31986 "Dmel_ BcDNA:AT26906, Dmel\CG15296 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010375 31986 CG15296 http://www.ncbi.nlm.nih.gov/gene/?term=31986 "Dmel_ BcDNA:AT26906, Dmel\CG15296 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010376 319876 Cobll1 http://www.ncbi.nlm.nih.gov/gene/?term=319876 "1810047P18Rik, Coblr1, D430044D16Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010377 319876 Cobll1 http://www.ncbi.nlm.nih.gov/gene/?term=319876 "1810047P18Rik, Coblr1, D430044D16Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010378 31987 spri http://www.ncbi.nlm.nih.gov/gene/?term=31987 "Dmel_CG34414, CG12638, CG15297, CG15298, CG15299, CG15300, CG15301, CG32674, CG32680, CG33175, CG34414, Dmel\CG34414, Dmel_CG32680, Dmel_CG33175, Rin1, Spri, anon-WO03040301.275 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010379 319885 Zcchc7 http://www.ncbi.nlm.nih.gov/gene/?term=319885 "4930572I07Rik, D4Wsu132e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010380 319929 A630076J17Rik http://www.ncbi.nlm.nih.gov/gene/?term=319929 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010381 319945 Flad1 http://www.ncbi.nlm.nih.gov/gene/?term=319945 "A930017E24Rik, Pp591 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010382 319951 A230001M10Rik http://www.ncbi.nlm.nih.gov/gene/?term=319951 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010383 319965 Cc2d1b http://www.ncbi.nlm.nih.gov/gene/?term=319965 "A830039B04Rik, Freud2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010384 319982 5930430L01Rik http://www.ncbi.nlm.nih.gov/gene/?term=319982 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010385 319996 Casc4 http://www.ncbi.nlm.nih.gov/gene/?term=319996 "D130060C09Rik, VGFG2573 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010386 319997 A630001G21Rik http://www.ncbi.nlm.nih.gov/gene/?term=319997 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010387 319998 Tmem198 http://www.ncbi.nlm.nih.gov/gene/?term=319998 "A230078I05Rik-1, Tmem198a, Tmem198 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010388 31 ACACA http://www.ncbi.nlm.nih.gov/gene/?term=31 "ACAC, ACACAD, ACC, ACC1, ACCA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010389 31 ACACA http://www.ncbi.nlm.nih.gov/gene/?term=31 "ACACD, ACC, ACC1, ACCA, ACACA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010390 31 ACACA http://www.ncbi.nlm.nih.gov/gene/?term=31 "ACACD, ACC, ACC1, ACCA, ACACA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010391 31 ACACA http://www.ncbi.nlm.nih.gov/gene/?term=31 "ACACD, ACC, ACC1, ACCA, ACACA " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010392 320011 Uggt1 http://www.ncbi.nlm.nih.gov/gene/?term=320011 "0910001L17Rik, A930007H10Rik, AA589501, AI414429, AI448372, C820010P03Rik, GT, UGT1, Ugcgl1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010393 320020 6330415G19Rik http://www.ncbi.nlm.nih.gov/gene/?term=320020 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010394 32005 CG32676 http://www.ncbi.nlm.nih.gov/gene/?term=32005 "Dmel_ CG9725, CG9732, Dmel\CG32676 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010395 32005 CG32676 http://www.ncbi.nlm.nih.gov/gene/?term=32005 "Dmel_ CG9725, CG9732, Dmel\CG32676 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010396 32005 CG32676 http://www.ncbi.nlm.nih.gov/gene/?term=32005 "Dmel_ CG9725, CG9732, Dmel\CG32676 " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010397 32007 sesB http://www.ncbi.nlm.nih.gov/gene/?term=32007 "Dmel_CG16944, A/A-T, A/A-T/sesB, ADP/ATP translocase, ADT2, ANT, ANT1, CG16944, Dmel\CG16944, EM12, Hmr, S12, SesB, anon-WO02059370.55, dANT, jive, l(1)9Ed, l(1)9Fa, l(1)DC701, l(1)EM31, l(1)G0126, l(1)G0247, l(1)G0386, l(1)S12, orangi, ses B " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010398 32007 sesB http://www.ncbi.nlm.nih.gov/gene/?term=32007 "Dmel_CG16944, A/A-T, A/A-T/sesB, ADP/ATP translocase, ADT2, ANT, ANT1, CG16944, Dmel\CG16944, EM12, Hmr, S12, SesB, anon-WO02059370.55, dANT, jive, l(1)9Ed, l(1)9Fa, l(1)DC701, l(1)EM31, l(1)G0126, l(1)G0247, l(1)G0386, l(1)S12, orangi, ses B " mRNA Drosophila melanogaster 25838129 Perinuclear Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010399 320082 Fbxw21 http://www.ncbi.nlm.nih.gov/gene/?term=320082 E330009P21Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010400 320092 E030003E18Rik http://www.ncbi.nlm.nih.gov/gene/?term=320092 1700127G21Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010401 320095 6430550D23Rik http://www.ncbi.nlm.nih.gov/gene/?term=320095 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010402 32009 Imp http://www.ncbi.nlm.nih.gov/gene/?term=32009 "Dmel_CG1691, CG1691, Dmel\CG1691, IGF-II, IGF2BP1, IMP, IMP-1, MRE11, ORE-9, anon-EST:fe2B3, anon-WO0140519.39, cg1691, dIMP, imp, l(1)G0072, mre11 " mRNA Drosophila melanogaster 17923096 Posterior Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00010403 32009 Imp http://www.ncbi.nlm.nih.gov/gene/?term=32009 "Dmel_CG1691, CG1691, Dmel\CG1691, IGF-II, IGF2BP1, IMP, IMP-1, MRE11, ORE-9, anon-EST:fe2B3, anon-WO0140519.39, cg1691, dIMP, imp, l(1)G0072, mre11 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010404 32009 Imp http://www.ncbi.nlm.nih.gov/gene/?term=32009 "Dmel_CG1691, CG1691, Dmel\CG1691, IGF-II, IGF2BP1, IMP, IMP-1, MRE11, ORE-9, anon-EST:fe2B3, anon-WO0140519.39, cg1691, dIMP, imp, l(1)G0072, mre11 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010405 320100 Relt http://www.ncbi.nlm.nih.gov/gene/?term=320100 "E430021K24Rik, Tnfrsf19l " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010406 320117 C730049O14Rik http://www.ncbi.nlm.nih.gov/gene/?term=320117 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010407 320129 Adrbk2 http://www.ncbi.nlm.nih.gov/gene/?term=320129 "4833444A01Rik, AI851927, AW551196, Adrbk-2, Bark-2, GRK3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010408 320150 Zdhhc17 http://www.ncbi.nlm.nih.gov/gene/?term=320150 "A230053P19Rik, BB187739, D130071N24Rik, Hip14 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010409 320162 Cep95 http://www.ncbi.nlm.nih.gov/gene/?term=320162 "4732496G21Rik, AI118346, AI448335, Ccdc45, D330027A14Rik, F630025I20Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010410 320165 Tacc1 http://www.ncbi.nlm.nih.gov/gene/?term=320165 "4833447E04Rik, AA960202, B230378H13Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010411 320168 9630050E16Rik http://www.ncbi.nlm.nih.gov/gene/?term=320168 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010412 320172 E230016M11Rik http://www.ncbi.nlm.nih.gov/gene/?term=320172 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010413 320203 C130071C03Rik http://www.ncbi.nlm.nih.gov/gene/?term=320203 2810449C10Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010414 320206 A730028G07Rik http://www.ncbi.nlm.nih.gov/gene/?term=320206 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010415 320226 Ccdc171 http://www.ncbi.nlm.nih.gov/gene/?term=320226 "4930418J05Rik, 4930473A06Rik, A330015D16Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010416 320260 A230059L01Rik http://www.ncbi.nlm.nih.gov/gene/?term=320260 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010417 320266 D130060J02Rik http://www.ncbi.nlm.nih.gov/gene/?term=320266 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010418 320267 Fubp3 http://www.ncbi.nlm.nih.gov/gene/?term=320267 "A330051M14Rik, AV006371, FBP3, Marta2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010419 320271 Scai http://www.ncbi.nlm.nih.gov/gene/?term=320271 "9330112M16, A930041I02Rik, AI662729 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010420 320271 Scai http://www.ncbi.nlm.nih.gov/gene/?term=320271 "9330112M16, A930041I02Rik, AI662729 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010421 320274 9330209N08Rik http://www.ncbi.nlm.nih.gov/gene/?term=320274 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010422 320289 B830004H01Rik http://www.ncbi.nlm.nih.gov/gene/?term=320289 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010423 320299 Iqcb1 http://www.ncbi.nlm.nih.gov/gene/?term=320299 "6820449I09Rik, AV128382, NPHP5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010424 320302 Glt28d2 http://www.ncbi.nlm.nih.gov/gene/?term=320302 "4732486J07Rik, Glt28d1l " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010425 320316 9330164J24Rik http://www.ncbi.nlm.nih.gov/gene/?term=320316 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010426 320321 9430077A04Rik http://www.ncbi.nlm.nih.gov/gene/?term=320321 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010427 320331 D230015J17Rik http://www.ncbi.nlm.nih.gov/gene/?term=320331 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010428 320391 D930017J03Rik http://www.ncbi.nlm.nih.gov/gene/?term=320391 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010429 320394 Cenpt http://www.ncbi.nlm.nih.gov/gene/?term=320394 G630055P03Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010430 320406 A630009H07Rik http://www.ncbi.nlm.nih.gov/gene/?term=320406 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010431 320411 A730089K16Rik http://www.ncbi.nlm.nih.gov/gene/?term=320411 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010432 320415 Gchfr http://www.ncbi.nlm.nih.gov/gene/?term=320415 "2010323F13Rik, GFRP, P35 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010433 320430 C230073G13Rik http://www.ncbi.nlm.nih.gov/gene/?term=320430 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010434 320435 Rinl http://www.ncbi.nlm.nih.gov/gene/?term=320435 "5830482F20Rik, 9930116N10Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010435 320438 Alg6 http://www.ncbi.nlm.nih.gov/gene/?term=320438 E230028F23Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010436 320460 Vwc2l http://www.ncbi.nlm.nih.gov/gene/?term=320460 "A830006F12Rik, Brl " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010437 320471 D230022J07Rik http://www.ncbi.nlm.nih.gov/gene/?term=320471 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010438 320473 Heatr5b http://www.ncbi.nlm.nih.gov/gene/?term=320473 "2010013B10Rik, A230048G03Rik, AV071430, D330050P16Rik, mKIAA1414 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010439 320478 Sox2ot http://www.ncbi.nlm.nih.gov/gene/?term=320478 B230215L15Rik lncRNA Mus musculus 19767420 Nucleus Embryonic stem cell In situ hybridization|qRT-PCR "SOX2OT was originally reported as a spliced ncRNA mapping to human chromosome 3q26.3-q27, with an intron overlapping the SOX2 gene in the same transcriptional orientation (Fantes et al. 2003). " RLID00010440 320478 Sox2ot http://www.ncbi.nlm.nih.gov/gene/?term=320478 B230215L15Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010441 320487 Heatr5a http://www.ncbi.nlm.nih.gov/gene/?term=320487 "C230081H03Rik, D930036F22Rik, mKIAA1316 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010442 320492 A830018L16Rik http://www.ncbi.nlm.nih.gov/gene/?term=320492 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010443 320502 Lmod3 http://www.ncbi.nlm.nih.gov/gene/?term=320502 5430424A14Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010444 320506 Lmbrd2 http://www.ncbi.nlm.nih.gov/gene/?term=320506 9930036E21Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010445 320512 D930014O13Rik http://www.ncbi.nlm.nih.gov/gene/?term=320512 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010446 320556 C230085N15Rik http://www.ncbi.nlm.nih.gov/gene/?term=320556 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010447 32057 Dlic http://www.ncbi.nlm.nih.gov/gene/?term=32057 "Dmel_CG1938, CG1938, D-LIC, DLIC, DLIC22, Dmel\CG1938, dlic, dlic2, l(1)G0065, l(1)G0190, Dlic " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010448 320581 Idi2 http://www.ncbi.nlm.nih.gov/gene/?term=320581 "4833405L16Rik, IPPI2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010449 320587 Tmem88b http://www.ncbi.nlm.nih.gov/gene/?term=320587 A230069A22Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010450 320589 9530020O07Rik http://www.ncbi.nlm.nih.gov/gene/?term=320589 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010451 3205 HOXA9 http://www.ncbi.nlm.nih.gov/gene/?term=3205 "ABD-B, HOX1, HOX1.7, HOX1G " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010452 3205 HOXA9 http://www.ncbi.nlm.nih.gov/gene/?term=3205 "ABD-B, HOX1, HOX1.7, HOX1G " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010453 320604 Ccdc169 http://www.ncbi.nlm.nih.gov/gene/?term=320604 A730037C10Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010454 320615 Dopey1 http://www.ncbi.nlm.nih.gov/gene/?term=320615 "B130005I07Rik, BC035275, C130028L17, D9Ertd809e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010455 320621 D830044D21Rik http://www.ncbi.nlm.nih.gov/gene/?term=320621 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010456 320632 Snrnp200 http://www.ncbi.nlm.nih.gov/gene/?term=320632 "A330064G03Rik, Ascc3l1, BC011390, HELIC2, U5-200-KD, U5-200KD " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010457 320633 Zbtb26 http://www.ncbi.nlm.nih.gov/gene/?term=320633 A630026F21Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010458 320642 A630066F11Rik http://www.ncbi.nlm.nih.gov/gene/?term=320642 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010459 320675 4921513D23Rik http://www.ncbi.nlm.nih.gov/gene/?term=320675 BC031575 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010460 320698 C530042K13Rik http://www.ncbi.nlm.nih.gov/gene/?term=320698 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010461 320701 Fam19a4 http://www.ncbi.nlm.nih.gov/gene/?term=320701 "C130034I18Rik Tafa-4, Tafa-4, Fam19a4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010462 320706 Soga1 http://www.ncbi.nlm.nih.gov/gene/?term=320706 "9830001H06Rik, AI426038, D430036N24Rik, Soga " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010463 320714 Trappc11 http://www.ncbi.nlm.nih.gov/gene/?term=320714 "AW558465, D030016E14Rik, R75422 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010464 320717 Pptc7 http://www.ncbi.nlm.nih.gov/gene/?term=320717 "9130017A15Rik, AA672638, AI848390, TA-PP2C " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010465 320720 Fastkd1 http://www.ncbi.nlm.nih.gov/gene/?term=320720 "5330408N05Rik, mKIAA1800 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010466 320746 5330437M03Rik http://www.ncbi.nlm.nih.gov/gene/?term=320746 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010467 32075 CG1738 http://www.ncbi.nlm.nih.gov/gene/?term=32075 "Dmel_ BcDNA:RE11532, Dmel\CG1738 " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010468 320766 E030022I16Rik http://www.ncbi.nlm.nih.gov/gene/?term=320766 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010469 320772 Mdga2 http://www.ncbi.nlm.nih.gov/gene/?term=320772 "6720489L24Rik, 9330209L04Rik, Adp, Mamdc1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010470 320787 9130221L21Rik http://www.ncbi.nlm.nih.gov/gene/?term=320787 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010471 320790 Chd7 http://www.ncbi.nlm.nih.gov/gene/?term=320790 "A730019I05Rik, Cycn, Cyn, Dz, Edy, Flo, GENA 47, GENA 60, Gena 52, Lda, Mt, Obt, Todo, WBE1, Whi, metis " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010472 320790 Chd7 http://www.ncbi.nlm.nih.gov/gene/?term=320790 "A730019I05Rik, Cycn, Cyn, Dz, Edy, Flo, GENA 47, GENA 60, Gena 52, Lda, Mt, Obt, Todo, WBE1, Whi, metis " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010473 320799 Zhx3 http://www.ncbi.nlm.nih.gov/gene/?term=320799 "1810059C13Rik, 4932418O04Rik, 9530010N21Rik, Tix1, mKIAA0395 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010474 3207 HOXA11 http://www.ncbi.nlm.nih.gov/gene/?term=3207 "HOX1, HOX1I, RUSAT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010475 320806 Gfm2 http://www.ncbi.nlm.nih.gov/gene/?term=320806 "6530419G12Rik, A930009M04Rik, EF-G2mt, EFG2, MST027, RRF2mt " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010476 320816 Ankrd16 http://www.ncbi.nlm.nih.gov/gene/?term=320816 "2810455F06Rik, AI646698, D430029B21Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010477 320822 4732417M03Rik http://www.ncbi.nlm.nih.gov/gene/?term=320822 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010478 320825 Samd5 http://www.ncbi.nlm.nih.gov/gene/?term=320825 E130306M17Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010479 320829 C430014B12Rik http://www.ncbi.nlm.nih.gov/gene/?term=320829 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010480 32083 dlg1 http://www.ncbi.nlm.nih.gov/gene/?term=32083 "Dmel_CG1725, 11, CG1725, CG1730, CPD, DLG, DLG-A, DLG1, Discs-large, Dlg, Dlg-A, Dlg1, DlgA, DlgS97, Dmel\CG1725, Drodlg, PSD95, SAP97, anon-EST:Posey93, anon-WO03040301.258, anon-WO03040301.260, anon-WO03040301.268, d. lg.-1, dlg, dlg-1, dlg-A, dlgA, dlgS97, l(1)10Bf, l(1)G0276, l(1)G0342, l(1)G0456, l(1)G19, l(1)L11, l(1)bwn, l(1)d.lg-1, l(1)d.lg.-1, l(1)discs large, l(1)dlg, l(1)dlg-1, l(1)dlg1, l(1)l.pr.-2, l(1)lpr-2, misb " mRNA Drosophila melanogaster 17923096 Cell junction Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00010481 320841 9230115F04Rik http://www.ncbi.nlm.nih.gov/gene/?term=320841 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010482 320864 Krt26 http://www.ncbi.nlm.nih.gov/gene/?term=320864 "4732407F15Rik, Krt25b " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010483 320873 Cdh10 http://www.ncbi.nlm.nih.gov/gene/?term=320873 "A830016G23Rik, C030003B10Rik, C030011H18Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010484 320873 Cdh10 http://www.ncbi.nlm.nih.gov/gene/?term=320873 "A830016G23Rik, C030003B10Rik, C030011H18Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010485 320893 6430562O15Rik http://www.ncbi.nlm.nih.gov/gene/?term=320893 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010486 3208 HPCA http://www.ncbi.nlm.nih.gov/gene/?term=3208 "BDR2, DYT2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010487 320910 Itgb8 http://www.ncbi.nlm.nih.gov/gene/?term=320910 4832412O06Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010488 320929 4732460I02Rik http://www.ncbi.nlm.nih.gov/gene/?term=320929 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010489 320938 Tnpo3 http://www.ncbi.nlm.nih.gov/gene/?term=320938 "5730544L10Rik, C430013M08Rik, C81142, D6Ertd313e, Trn-SR, mKIAA4133 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010490 32093 Cyp4g15 http://www.ncbi.nlm.nih.gov/gene/?term=32093 "Dmel_CG11715, 152658_at, 4g15, CG11715, Dmel\CG11715 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010491 320949 D830039M14Rik http://www.ncbi.nlm.nih.gov/gene/?term=320949 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010492 320951 Pisd http://www.ncbi.nlm.nih.gov/gene/?term=320951 9030221M09Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010493 320975 D330050G23Rik http://www.ncbi.nlm.nih.gov/gene/?term=320975 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010494 320999 9530019H20Rik http://www.ncbi.nlm.nih.gov/gene/?term=320999 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010495 320 APBA1 http://www.ncbi.nlm.nih.gov/gene/?term=320 "D9S411E, LIN10, MINT1, X11, X11A, X11ALPHA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010496 321000 Lrif1 http://www.ncbi.nlm.nih.gov/gene/?term=321000 "2010012G17Rik, 4933421E11Rik, AI450568 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010497 321006 Vprbp http://www.ncbi.nlm.nih.gov/gene/?term=321006 "AI447437, B930007L02Rik, mKIAA0800 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010498 321015 5330439B14Rik http://www.ncbi.nlm.nih.gov/gene/?term=321015 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010499 321022 Cdv3 http://www.ncbi.nlm.nih.gov/gene/?term=321022 "2510010F10Rik, C230084J24Rik, C79446, TPP36 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010500 321022 Cdv3 http://www.ncbi.nlm.nih.gov/gene/?term=321022 "2510010F10Rik, C230084J24Rik, C79446, TPP36 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010501 32102 Kmn1 http://www.ncbi.nlm.nih.gov/gene/?term=32102 "Dmel_CG1558, CG1558, CT4038, Dmel\CG1558, Nsl1, anon-WO03040301.201, dmNsl1R, l(1)G0237, nsl1 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010502 32124 prtp http://www.ncbi.nlm.nih.gov/gene/?term=32124 "Dmel_CG1837, CG1837, Dmel\CG1837, anon-EST:Posey253, p47 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010503 32140 p24-1 http://www.ncbi.nlm.nih.gov/gene/?term=32140 "Dmel_CG1967, CG1967, Dmel\CG1967, anon-EST:Liang-1.45, clone 1.45, p24, p24.1, p26/p24gamma4 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010504 3215 HOXB5 http://www.ncbi.nlm.nih.gov/gene/?term=3215 "HHO.C10, HOX2, HOX2A, HU-1, Hox2.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010505 3216 HOXB6 http://www.ncbi.nlm.nih.gov/gene/?term=3216 "HOX2, HOX2B, HU-2, Hox-2.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010506 32174 Muc11A http://www.ncbi.nlm.nih.gov/gene/?term=32174 "Dmel_CG32656, CG2779, CG32656, Dmel\CG32656 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010507 32174 Muc11A http://www.ncbi.nlm.nih.gov/gene/?term=32174 "Dmel_CG32656, CG2779, CG32656, Dmel\CG32656 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010508 32179 CG2750 http://www.ncbi.nlm.nih.gov/gene/?term=32179 "Dmel_ Dmel\CG2750, anon-WO0140519.124 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010509 3217 HOXB7 http://www.ncbi.nlm.nih.gov/gene/?term=3217 "HHO.C1, HOX2, HOX2C, Hox-2.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010510 3217 HOXB7 http://www.ncbi.nlm.nih.gov/gene/?term=3217 "HHO.C1, HOX2, HOX2C, Hox-2.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010511 32194 CG15731 http://www.ncbi.nlm.nih.gov/gene/?term=32194 Dmel_ Dmel\CG15731 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010512 321 APBA2 http://www.ncbi.nlm.nih.gov/gene/?term=321 "D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11-BETA, X11L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010513 32273 sno http://www.ncbi.nlm.nih.gov/gene/?term=32273 "Dmel_CG44436, CG1903, CG44436, Dmel\CG44436, Dmel_CG1903, Sno, g-l, l(1)11Ea " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00010514 32275 mew http://www.ncbi.nlm.nih.gov/gene/?term=32275 "Dmel_CG1771, CG1771, CT5254, Dmel\CG1771, ItgaPS1, PS1, PS1alpha, PSalpha1, aPS1, alpha-PS1, alpha1Int, alphaPS1, alpha[[PS1]], l(1)G0429, l(1)G0443 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010515 32285 IP3K2 http://www.ncbi.nlm.nih.gov/gene/?term=32285 "Dmel_CG45017, CG12724, CG15745, CG1630, CG34359, CG4501, CG45017, D-IP3K2, DIP3K2, Dmel\CG45017, Dmel_CG12724, Dmel_CG15745, Dmel_CG1630, Dmel_CG34359, IP[[3]]K-2, IP[[3]]K2, NP2758, dmIP3K2, dmIP3Kbeta, dmIP[[3]]beta, ip3k2 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010516 32285 IP3K2 http://www.ncbi.nlm.nih.gov/gene/?term=32285 "Dmel_CG45017, CG12724, CG15745, CG1630, CG34359, CG4501, CG45017, D-IP3K2, DIP3K2, Dmel\CG45017, Dmel_CG12724, Dmel_CG15745, Dmel_CG1630, Dmel_CG34359, IP[[3]]K-2, IP[[3]]K2, NP2758, dmIP3K2, dmIP3Kbeta, dmIP[[3]]beta, ip3k2 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010517 322903 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=322903 "fb76c12, wu:fb76c12, wu:fb93h11, wu:fb98e07, wu:fq21a10 " mRNA Danio rerio 17293094 Germ plasm Oocyte In situ hybridization "Here we report that the germ plasm RNAs vasa, nanos1, and dazl co-localize with the mitochondrial cloud (MC) and are transported to the vegetal cortex during early oogenesis. " RLID00010518 322903 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=322903 "fb76c12, wu:fb76c12, wu:fb93h11, wu:fb98e07, wu:fq21a10 " mRNA Danio rerio 17293094 Mitochondrion Oocyte In situ hybridization "Here we report that the germ plasm RNAs vasa, nanos1, and dazl co-localize with the mitochondrial cloud (MC) and are transported to the vegetal cortex during early oogenesis. " RLID00010519 32312 Tango13 http://www.ncbi.nlm.nih.gov/gene/?term=32312 "Dmel_CG32632, CG1573, CG15758, CG15759, CG32629, CG32629/CG32632, CG32632, Dmel\CG32632, Dmel_CG15758, Dmel_CG32629, TANGO13 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010520 32312 Tango13 http://www.ncbi.nlm.nih.gov/gene/?term=32312 "Dmel_CG32632, CG1573, CG15758, CG15759, CG32629, CG32629/CG32632, CG32632, Dmel\CG32632, Dmel_CG15758, Dmel_CG32629, TANGO13 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010521 32312 Tango13 http://www.ncbi.nlm.nih.gov/gene/?term=32312 "Dmel_CG32632, CG1573, CG15758, CG15759, CG32629, CG32629/CG32632, CG32632, Dmel\CG32632, Dmel_CG15758, Dmel_CG32629, TANGO13 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010522 32327 CG11158 http://www.ncbi.nlm.nih.gov/gene/?term=32327 Dmel_ Dmel\CG11158 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010523 32348 CG11095 http://www.ncbi.nlm.nih.gov/gene/?term=32348 Dmel_ Dmel\CG11095 mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010524 32348 CG11095 http://www.ncbi.nlm.nih.gov/gene/?term=32348 Dmel_ Dmel\CG11095 mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010525 32348 CG11095 http://www.ncbi.nlm.nih.gov/gene/?term=32348 Dmel_ Dmel\CG11095 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010526 3234 HOXD8 http://www.ncbi.nlm.nih.gov/gene/?term=3234 "HOX4, HOX4E, HOX5.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010527 32352 AMPdeam http://www.ncbi.nlm.nih.gov/gene/?term=32352 "Dmel_CG32626, AMP deam, CG11058, CG11065, CG15762, CG32626, Dmel\CG32626 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010528 3235 HOXD9 http://www.ncbi.nlm.nih.gov/gene/?term=3235 "HOX4, HOX4C, Hox-4.3, Hox-5.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010529 32392 CG9411 http://www.ncbi.nlm.nih.gov/gene/?term=32392 Dmel_ Dmel\CG9411 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010530 32398 NetA http://www.ncbi.nlm.nih.gov/gene/?term=32398 "Dmel_CG18657, CG18657, CT27014, Dmel\CG18657, NetrinA, net, netA, netrin, netrin A " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010531 323 APBB2 http://www.ncbi.nlm.nih.gov/gene/?term=323 "FE65L, FE65L1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010532 323 APBB2 http://www.ncbi.nlm.nih.gov/gene/?term=323 "FE65L, FE65L1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010533 32400 NetB http://www.ncbi.nlm.nih.gov/gene/?term=32400 "Dmel_CG10521, CG10521, CT29512, Dmel\CG10521, NETB, net, netB, netrin, netrin B " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00010534 32407 CG14408 http://www.ncbi.nlm.nih.gov/gene/?term=32407 Dmel_ Dmel\CG14408 mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00010535 3241 HPCAL1 http://www.ncbi.nlm.nih.gov/gene/?term=3241 "BDR1, HLP2, VILIP-3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010536 32488 CG7860 http://www.ncbi.nlm.nih.gov/gene/?term=32488 Dmel_ Dmel\CG7860 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010537 32490 CG9213 http://www.ncbi.nlm.nih.gov/gene/?term=32490 "Dmel_ CG32585, Dmel\CG9213 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010538 32498 sog http://www.ncbi.nlm.nih.gov/gene/?term=32498 "Dmel_CG9224, CG9224, Dm sog, Dmel\CG9224, SOG, Sog, l(1)G0160, l(1)G0395, l(1)G0479 " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00010539 324 APC http://www.ncbi.nlm.nih.gov/gene/?term=324 "BTPS2, DP2, DP2.5, DP3, GS, PPP1R46 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010540 324 APC http://www.ncbi.nlm.nih.gov/gene/?term=324 "BTPS2, DP2, DP2.5, DP3, GS, PPP1R46 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010541 324 APC http://www.ncbi.nlm.nih.gov/gene/?term=324 "BTPS2, DP2, DP2.5, DP3, GS, PPP1R46 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010542 3251 HPRT1 http://www.ncbi.nlm.nih.gov/gene/?term=3251 "HGPRT, HPRT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010543 3251 HPRT1 http://www.ncbi.nlm.nih.gov/gene/?term=3251 "HGPRT, HPRT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010544 3251 HPRT1 http://www.ncbi.nlm.nih.gov/gene/?term=3251 "HGPRT, HPRT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010545 32530 mRpS30 http://www.ncbi.nlm.nih.gov/gene/?term=32530 "Dmel_CG8470, CG8470, Dmel\CG8470, MRP-S30, mRSp30 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010546 32535 CG8509 http://www.ncbi.nlm.nih.gov/gene/?term=32535 Dmel_ Dmel\CG8509 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010547 32536 sd http://www.ncbi.nlm.nih.gov/gene/?term=32536 "Dmel_CG8544, CG8544, DROEXO, DROEXO2, Dmel\CG8544, EP(X)1088, EP1088, SD, Sd, TEAD, anon-EST:Liang-2.14, clone 2.14, l(1)G0239, l(1)G0262, l(1)G0309, l(1)G0315, l(1)G0483, l(1)HF394, l(1)III, sp " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00010548 32544 Gbeta13F http://www.ncbi.nlm.nih.gov/gene/?term=32544 "Dmel_CG10545, CG10545, Dmel\CG10545, G b13F, G-beta, G-betab, G[[beta13F]], G[[beta]], Gb13F, Gbb, Gbeta, anon-EST:Liang-1.22, clone 1.22, dgbeta, gbeta13F " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010549 32548 MSBP http://www.ncbi.nlm.nih.gov/gene/?term=32548 "Dmel_CG9066, CG9066, Dmel\CG9066, dm_MSBP " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010550 32566 eIF5 http://www.ncbi.nlm.nih.gov/gene/?term=32566 "Dmel_CG9177, CG9177, Dmel\CG9177, EIf5, anon-EST:fe3C6 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010551 3257 HPS1 http://www.ncbi.nlm.nih.gov/gene/?term=3257 "BLOC3S1, HPS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010552 32587 caz http://www.ncbi.nlm.nih.gov/gene/?term=32587 "Dmel_CG3606, BcDNA:GM09207, CG3606, Caz, Dmel\CG3606, EWSR1, P19, Pen19, SARFH, Sarfh, TFIID, anon-Pen19, cas, p19, pen19 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010553 32599 CG9921 http://www.ncbi.nlm.nih.gov/gene/?term=32599 Dmel_ Dmel\CG9921 mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010554 325 APCS http://www.ncbi.nlm.nih.gov/gene/?term=325 "HEL-S-92n, PTX2, SAP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010555 32602 U2af50 http://www.ncbi.nlm.nih.gov/gene/?term=32602 "Dmel_CG9998, 9-21, CG9998, DU2AF50, DmU2AF[50], Dmel\CG9998, U2AF, U2AF 50, U2AF-50, U2AF50, U2af, dU2AF50, dU2AF[50], dUTAf[50], l(1)14Ca, l(1)14Cc, l(1)9-21 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010556 326148 CG31523 http://www.ncbi.nlm.nih.gov/gene/?term=326148 "Dmel_ CG9798, Dmel\CG31523 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010557 326255 4EHP http://www.ncbi.nlm.nih.gov/gene/?term=326255 "Dmel_CG33100, 4E-HP, CG10716, CG33100, CT30033, Dmel\CG33100, d4EHP, eIF4E-8 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010558 326255 4EHP http://www.ncbi.nlm.nih.gov/gene/?term=326255 "Dmel_CG33100, 4E-HP, CG10716, CG33100, CT30033, Dmel\CG33100, d4EHP, eIF4E-8 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010559 32629 CG9784 http://www.ncbi.nlm.nih.gov/gene/?term=32629 "Dmel_ Dmel\CG9784, IPP, lincRNA.S9473 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010560 32651 CG9672 http://www.ncbi.nlm.nih.gov/gene/?term=32651 "Dmel_ BcDNA:GH16384, Dmel\CG9672, SPH161 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010561 3265 HRAS http://www.ncbi.nlm.nih.gov/gene/?term=3265 "C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010562 3265 HRAS http://www.ncbi.nlm.nih.gov/gene/?term=3265 "C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV1, RASH1, p21ras, HRAS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010563 326623 Tnfsf15 http://www.ncbi.nlm.nih.gov/gene/?term=326623 "Tl1, Tl1a, Tnlg1b, Vegi " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010564 326625 MMAB http://www.ncbi.nlm.nih.gov/gene/?term=326625 "ATR, CFAP23, cblB, cob " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010565 32663 CG9609 http://www.ncbi.nlm.nih.gov/gene/?term=32663 Dmel_ Dmel\CG9609 mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010566 32675 CG13003 http://www.ncbi.nlm.nih.gov/gene/?term=32675 Dmel_ Dmel\CG13003 mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010567 3267 AGFG1 http://www.ncbi.nlm.nih.gov/gene/?term=3267 "HRB, RAB, RIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010568 3267 AGFG1 http://www.ncbi.nlm.nih.gov/gene/?term=3267 "HRB, RAB, RIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010569 3267 AGFG1 http://www.ncbi.nlm.nih.gov/gene/?term=3267 "HRB, RAB, RIP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010570 3267 AGFG1 http://www.ncbi.nlm.nih.gov/gene/?term=3267 "HRB, RAB, RIP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010571 32691 CG4949 http://www.ncbi.nlm.nih.gov/gene/?term=32691 Dmel_ Dmel\CG4949 mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010572 32691 CG4949 http://www.ncbi.nlm.nih.gov/gene/?term=32691 Dmel_ Dmel\CG4949 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010573 327216 ofd1 http://www.ncbi.nlm.nih.gov/gene/?term=327216 "wu:fa07a10, wu:fd17e11, zgc:92562 " mRNA Danio rerio 18971206 Centrosome Embryo qRT-PCR "In wild-type embryos, ofd1 mRNA is widely expressed and Ofd1-green fluorescent protein (GFP) fusion localizes to the centrosome/basal body. " RLID00010574 32724 B-H1 http://www.ncbi.nlm.nih.gov/gene/?term=32724 "Dmel_CG5529, BH1, Bar, Bar H1, Bar-H1, BarH, BarHI, Barh1, CG5529, Dmel\CG5529, bar-h1, barH1, barh1 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010575 32727 p-cup http://www.ncbi.nlm.nih.gov/gene/?term=32727 "Dmel_CG12993, CG12993, Dmel\CG12993 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010576 327368 rgs14a http://www.ncbi.nlm.nih.gov/gene/?term=327368 "rgs14, wu:fi04g12 " mRNA Danio rerio 25049415 Germ plasm Embryo In situ hybridization "Rgs14a RNA is a previously unidentified component of the germ plasm strongly expressed in premigratory PGCs. Fig. 1. Zebrafish regulator of G-protein signaling 14a (rgs14a) RNA expression and Rgs14a protein localization. (A) A schematic representation of the Rgs14a protein structure showing the N-terminal RGS domain, the two Raf-like Ras-binding domains (RBD), and the C-terminal GoLoco domain. (B) Wholemount in situ RNA hybridization using rgs14a (Left) and nanos (Right) antisense RNA probes at the indicated embryonic stages; 5.3- and 10-hpf embryos were overstained in the case of rgs14a in situ hybridization to detect the weak expression in the PGCs. " RLID00010577 32737 stas http://www.ncbi.nlm.nih.gov/gene/?term=32737 "Dmel_CG8408, CG8408, Dmel\CG8408, Tmem41b " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010578 32739 corolla http://www.ncbi.nlm.nih.gov/gene/?term=32739 "Dmel_CG8316, CG8316, Dmel\CG8316, mei-39 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010579 32739 corolla http://www.ncbi.nlm.nih.gov/gene/?term=32739 "Dmel_CG8316, CG8316, Dmel\CG8316, mei-39 " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010580 32739 corolla http://www.ncbi.nlm.nih.gov/gene/?term=32739 "Dmel_CG8316, CG8316, Dmel\CG8316, mei-39 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010581 32748 chas http://www.ncbi.nlm.nih.gov/gene/?term=32748 "Dmel_CG32556, CG12987, CG12988, CG12989, CG32556, Dmel\CG32556, EP-631 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010582 32752 par-6 http://www.ncbi.nlm.nih.gov/gene/?term=32752 "Dmel_CG5884, CG5884, DPar-6, DPar6, Dm-Par-6, Dm-Par6, DmPAR-6, DmPar-6, DmPar6, Dmel\CG5884, Dmpar6, PAR-6, PAR6, Par, Par-6, Par6, dPAR-6, dPar-6, dmPar-6, par, par6 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010583 32757 unc-4 http://www.ncbi.nlm.nih.gov/gene/?term=32757 "Dmel_CG6269, CG6269, DPHD-1, Dmel\CG6269, D Unc4 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010584 3275 PRMT2 http://www.ncbi.nlm.nih.gov/gene/?term=3275 HRMT1L1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010585 3275 PRMT2 http://www.ncbi.nlm.nih.gov/gene/?term=3275 HRMT1L1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010586 3276 PRMT1 http://www.ncbi.nlm.nih.gov/gene/?term=3276 "ANM1, HCP1, HRMT1L2, IR1B4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010587 3276 PRMT1 http://www.ncbi.nlm.nih.gov/gene/?term=3276 "ANM1, HCP1, HRMT1L2, IR1B4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010588 3276 PRMT1 http://www.ncbi.nlm.nih.gov/gene/?term=3276 "ANM1, HCP1, HRMT1L2, IR1B4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010589 327762 Dna2 http://www.ncbi.nlm.nih.gov/gene/?term=327762 "Dna2l, E130315B21Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010590 327781 A130033P14 http://www.ncbi.nlm.nih.gov/gene/?term=327781 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010591 327857 A330087I24 http://www.ncbi.nlm.nih.gov/gene/?term=327857 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010592 32786 CG7536 http://www.ncbi.nlm.nih.gov/gene/?term=32786 Dmel_ Dmel\CG7536 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010593 327987 Med13 http://www.ncbi.nlm.nih.gov/gene/?term=327987 "1110067M05Rik, D030023K18, Thrap1, Trap240 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010594 327988 Gm9975 http://www.ncbi.nlm.nih.gov/gene/?term=327988 "C730049P21, ENSMUSG00000055697 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010595 32799 Frq2 http://www.ncbi.nlm.nih.gov/gene/?term=32799 "Dmel_CG5907, CG5907, Dmel\CG5907, Frq, frq, frq2 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010596 327 APEH http://www.ncbi.nlm.nih.gov/gene/?term=327 "AARE, ACPH, APH, D3F15S2, D3S48E, DNF15S2, OPH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010597 327 APEH http://www.ncbi.nlm.nih.gov/gene/?term=327 "AARE, ACPH, APH, D3F15S2, D3S48E, DNF15S2, OPH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010598 327 APEH http://www.ncbi.nlm.nih.gov/gene/?term=327 "AARE, ACPH, APH, D3F15S2, D3S48E, DNF15S2, OPH " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010599 327 APEH http://www.ncbi.nlm.nih.gov/gene/?term=327 "AARE, ACPH, APH, D3F15S2, D3S48E, DNF15S2, OPH " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010600 328099 Prps1l3 http://www.ncbi.nlm.nih.gov/gene/?term=328099 "AU021838, AW536152, Gm5081 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010601 3280 HES1 http://www.ncbi.nlm.nih.gov/gene/?term=3280 "HES-1, HHL, HRY, bHLHb39 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010602 328110 Prpf39 http://www.ncbi.nlm.nih.gov/gene/?term=328110 Srcs1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010603 328172 LOC328172 http://www.ncbi.nlm.nih.gov/gene/?term=328172 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010604 3281 HSBP1 http://www.ncbi.nlm.nih.gov/gene/?term=3281 NPC-A-13 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010605 32820 betaCOP http://www.ncbi.nlm.nih.gov/gene/?term=32820 "Dmel_CG6223, BcDNA.GH09317, BcDNA:GH09317, Beta Cop, BetaCop, CG6223, COPI, Dmel\CG6223, bcop, beta-COP, beta-Cop, beta-CopII, betaCop " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010606 32826 CG32548 http://www.ncbi.nlm.nih.gov/gene/?term=32826 "Dmel_ CG15051, CG6306, Dmel\CG32548, anon-WO0140519.88 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010607 32826 CG32548 http://www.ncbi.nlm.nih.gov/gene/?term=32826 "Dmel_ CG15051, CG6306, Dmel\CG32548, anon-WO0140519.88 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010608 328417 Parp4 http://www.ncbi.nlm.nih.gov/gene/?term=328417 "Adprtl1, C030027K23Rik, E230037B21Rik, Gm743, PARPL, PH5P, VAULT3, VPARP, p193 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010609 328572 Ep300 http://www.ncbi.nlm.nih.gov/gene/?term=328572 "A430090G16, A730011L11, KAT3B, p300, p300 HAT " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010610 32871 Atg101 http://www.ncbi.nlm.nih.gov/gene/?term=32871 "Dmel_CG7053, CG7053, Dmel\CG7053 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010611 32871 Atg101 http://www.ncbi.nlm.nih.gov/gene/?term=32871 "Dmel_CG7053, CG7053, Dmel\CG7053 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010612 328801 Zfp414 http://www.ncbi.nlm.nih.gov/gene/?term=328801 "0610030H11Rik, Znf414 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010613 328953 Gm5095 http://www.ncbi.nlm.nih.gov/gene/?term=328953 A730092B10 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010614 328963 G630071F17Rik http://www.ncbi.nlm.nih.gov/gene/?term=328963 G630071F17 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010615 328 APEX1 http://www.ncbi.nlm.nih.gov/gene/?term=328 "APE, APE1, APEN, APEX, APX, HAP1, REF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010616 328 APEX1 http://www.ncbi.nlm.nih.gov/gene/?term=328 "APE, APE1, APEN, APEX, APX, HAP1, REF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010617 328 APEX1 http://www.ncbi.nlm.nih.gov/gene/?term=328 "APE, APE1, APEN, APEX, APX, HAP1, REF1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010618 3290 HSD11B1 http://www.ncbi.nlm.nih.gov/gene/?term=3290 "11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010619 329122 4932436B18 http://www.ncbi.nlm.nih.gov/gene/?term=329122 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010620 3291 HSD11B2 http://www.ncbi.nlm.nih.gov/gene/?term=3291 "AME, AME1, HSD11K, HSD2, SDR9C3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010621 329260 Dennd1b http://www.ncbi.nlm.nih.gov/gene/?term=329260 "4632404N19Rik, 4930467M19Rik, 6820401H01Rik, F730008N07Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010622 329260 Dennd1b http://www.ncbi.nlm.nih.gov/gene/?term=329260 "4632404N19Rik, 4930467M19Rik, 6820401H01Rik, F730008N07Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010623 32926 out http://www.ncbi.nlm.nih.gov/gene/?term=32926 "Dmel_CG8062, BcDNA:LD28120, CG8062, Dmel\CG8062 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010624 32926 out http://www.ncbi.nlm.nih.gov/gene/?term=32926 "Dmel_CG8062, BcDNA:LD28120, CG8062, Dmel\CG8062 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010625 329271 C230024C17Rik http://www.ncbi.nlm.nih.gov/gene/?term=329271 C230024C17 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010626 329274 Fam163a http://www.ncbi.nlm.nih.gov/gene/?term=329274 A230106N23Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010627 32938 Pfrx http://www.ncbi.nlm.nih.gov/gene/?term=32938 "Dmel_CG3400, CG3400, Dmel\CG3400, PFK2 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010628 3293 HSD17B3 http://www.ncbi.nlm.nih.gov/gene/?term=3293 "EDH17B3, SDR12C2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010629 3295 HSD17B4 http://www.ncbi.nlm.nih.gov/gene/?term=3295 "DBP, MFE-2, MPF-2, PRLTS1, SDR8C1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010630 3295 HSD17B4 http://www.ncbi.nlm.nih.gov/gene/?term=3295 "DBP, MFE-2, MPF-2, PRLTS1, SDR8C1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010631 329716 BC107364 http://www.ncbi.nlm.nih.gov/gene/?term=329716 D730018G16 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010632 329739 Fam102b http://www.ncbi.nlm.nih.gov/gene/?term=329739 "1600010D10Rik, B430201A12Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010633 32976 dome http://www.ncbi.nlm.nih.gov/gene/?term=32976 "Dmel_CG14226, 142932_at, CG14226, CT33841, DOME, Dmel\CG14226, Dome, anon-18DEb, l(1)G0217, l(1)G0218, l(1)G0264, l(1)G0282, l(1)G0321, l(1)G0367, l(1)G0405, l(1)G0441, l(1)G0468, mom, vsp " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010634 32976 dome http://www.ncbi.nlm.nih.gov/gene/?term=32976 "Dmel_CG14226, 142932_at, CG14226, CT33841, DOME, Dmel\CG14226, Dome, anon-18DEb, l(1)G0217, l(1)G0218, l(1)G0264, l(1)G0282, l(1)G0321, l(1)G0367, l(1)G0405, l(1)G0441, l(1)G0468, mom, vsp " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010635 329777 Pigk http://www.ncbi.nlm.nih.gov/gene/?term=329777 3000001O05Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010636 329795 Tmem67 http://www.ncbi.nlm.nih.gov/gene/?term=329795 "5330408M12Rik, B230117O07, b2b1163.1Clo, b2b1291.1Clo " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010637 32981 Cdc42 http://www.ncbi.nlm.nih.gov/gene/?term=32981 "Dmel_CG12530, CDC42, CG12530Dm, D-CDC42, D-Cdc42, D-cdc42, DCDC42, DCdc42, Dcdc42, Dm Cdc42, DmCDC42, Dmcdc42, Dmel\CG12530, P40793, cdc42 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010638 3298 HSF2 http://www.ncbi.nlm.nih.gov/gene/?term=3298 "HSF 2, HSTF 2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010639 3298 HSF2 http://www.ncbi.nlm.nih.gov/gene/?term=3298 "HSF 2, HSTF 2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010640 329975 LOC329975 http://www.ncbi.nlm.nih.gov/gene/?term=329975 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010641 3299 HSF4 http://www.ncbi.nlm.nih.gov/gene/?term=3299 "CTM, CTRCT5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010642 329 BIRC2 http://www.ncbi.nlm.nih.gov/gene/?term=329 "API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010643 329 BIRC2 http://www.ncbi.nlm.nih.gov/gene/?term=329 "API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010644 32 ACACB http://www.ncbi.nlm.nih.gov/gene/?term=32 "ACC2, ACCB, HACC275 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010645 32 ACACB http://www.ncbi.nlm.nih.gov/gene/?term=32 "ACC2, ACCB, HACC275 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010646 330050 Fam185a http://www.ncbi.nlm.nih.gov/gene/?term=330050 "4631428I10, AI847670 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010647 33007 Dop2R http://www.ncbi.nlm.nih.gov/gene/?term=33007 "Dmel_CG33517, CG17004, CG33517, CG9569, D2R, DD2R, Dmel\CG33517, anon-WO0170980.130, anon-WO0170980.131, anon-WO0170980.31, anon-WO0170980.32, dD2R " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010648 330096 Shisa3 http://www.ncbi.nlm.nih.gov/gene/?term=330096 D830007B15Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010649 3300 DNAJB2 http://www.ncbi.nlm.nih.gov/gene/?term=3300 "CMT2T, DSMA5, HSJ-1, HSJ1, HSPF3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010650 330166 Miat http://www.ncbi.nlm.nih.gov/gene/?term=330166 "3632434I06, A230057G18Rik, Rncr2, gomafu " lncRNA Mus musculus 17623775 Nucleus Brain In situ hybridization|RT-PCR "Interestingly, spliced mature Gomafu RNA is localized to the nucleus despite its mRNA-like characteristics, which usually act as potent export signals to the cytoplasm. " RLID00010651 330166 Miat http://www.ncbi.nlm.nih.gov/gene/?term=330166 "3632434I06, A230057G18Rik, Rncr2, gomafu " lncRNA Mus musculus 20459797 Nucleus Retina cell In situ hybridization "We further report that RNCR2 RNA, which is normally nuclear-retained, can be exported from the nucleus when fused to an IRES-GFP sequence. " RLID00010652 330166 Miat http://www.ncbi.nlm.nih.gov/gene/?term=330166 "3632434I06, A230057G18Rik, Rncr2, gomafu " lncRNA Mus musculus 22070123 Nucleus Retinas cell In situ hybridization "Here, we discuss the functions of a distinct group of vertebrate-specific lncRNAs, NEAT1/MENε/β/VINC, MALAT1/NEAT2, and Gomafu/RNCR2/MIAT, which accumulate abundantly within the nucleus as RNA components of specific nuclear bodies. " RLID00010653 330166 Miat http://www.ncbi.nlm.nih.gov/gene/?term=330166 "3632434I06, A230057G18Rik, Rncr2, gomafu " lncRNA Mus musculus 26464439 Axon Motoneuron In situ hybridization|qRT-PCR "We then analyzed the abundance of several lncRNAs, namely Malat1, Meg3, Rmst, Xist and Miat. All of these lncRNAs were present in the axonal compartment. " RLID00010654 330173 2610524H06Rik http://www.ncbi.nlm.nih.gov/gene/?term=330173 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010655 330177 Taok3 http://www.ncbi.nlm.nih.gov/gene/?term=330177 "2900006A08Rik, A130052D22, A430105I05Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010656 330192 Vps37b http://www.ncbi.nlm.nih.gov/gene/?term=330192 "2300007F24Rik, AI415429, BC026744 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010657 3301 DNAJA1 http://www.ncbi.nlm.nih.gov/gene/?term=3301 "DJ-2, DjA1, HDJ2, HSDJ, HSJ-2, HSJ2, HSPF4, NEDD7, hDJ-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010658 3301 DNAJA1 http://www.ncbi.nlm.nih.gov/gene/?term=3301 "DJ-2, DjA1, HDJ2, HSDJ, HSJ-2, HSJ2, HSPF4, NEDD7, hDJ-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010659 330286 D630045J12Rik http://www.ncbi.nlm.nih.gov/gene/?term=330286 "Kiaa1549, mKIAA1549 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010660 3303 HSPA1A http://www.ncbi.nlm.nih.gov/gene/?term=3303 "HEL-S-103, HSP70-1, HSP70-1A, HSP70.1, HSP70I, HSP72, HSPA1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010661 330401 Tmcc1 http://www.ncbi.nlm.nih.gov/gene/?term=330401 "3632431M01Rik, mKIAA0779 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010662 33040 Obp19d http://www.ncbi.nlm.nih.gov/gene/?term=33040 "Dmel_CG1668, 19d, BcDNA:HL07789, BcDNA:RH68082, CG1668, DmelObp19d, Dmel\CG1668, PB-PRP2, PBP2, PBPRP-2, PBPRP2, Pbprp2, pbprp-2, pbprp2 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010663 330414 Gm5112 http://www.ncbi.nlm.nih.gov/gene/?term=330414 D530008I22 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010664 33045 mal http://www.ncbi.nlm.nih.gov/gene/?term=33045 "Dmel_CG1692, 5, CG1692, Dmel\CG1692, SRF, bz, ma-l " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010665 3304 HSPA1B http://www.ncbi.nlm.nih.gov/gene/?term=3304 "HSP70-1B, HSP70-2, HSP70.2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010666 330599 Gm16938 http://www.ncbi.nlm.nih.gov/gene/?term=330599 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010667 33059 run http://www.ncbi.nlm.nih.gov/gene/?term=33059 "Dmel_CG1849, 1, 2, AA33, CG1849, Dmel\CG1849, LB5, P235, RUN, Rnt, Run, Runt, l(1)19Ea, l(1)AA33, l(1)B2/13.1, l(1)LB9, lLB5, leg " mRNA Drosophila melanogaster 15280214 Basal Embryo In situ hybridization "Whereas embryos laid by wild-type mothers have an almost exclusively apical distribution of pair-rule mRNAs such as eve, ftz, h and runt (run), those laid by egl3e/eglWU50 mothers accumulate a large proportion of these transcripts in the basal cytoplasm (Fig. 5A). " RLID00010668 33059 run http://www.ncbi.nlm.nih.gov/gene/?term=33059 "Dmel_CG1849, 1, 2, AA33, CG1849, Dmel\CG1849, LB5, P235, RUN, Rnt, Run, Runt, l(1)19Ea, l(1)AA33, l(1)B2/13.1, l(1)LB9, lLB5, leg " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00010669 3305 HSPA1L http://www.ncbi.nlm.nih.gov/gene/?term=3305 "HSP70-1L, HSP70-HOM, HSP70T, hum70t " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010670 330695 Ctxn1 http://www.ncbi.nlm.nih.gov/gene/?term=330695 "BC028881, Ctxn " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010671 3306 HSPA2 http://www.ncbi.nlm.nih.gov/gene/?term=3306 "HSP70-2, HSP70-3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010672 330766 LOC330766 http://www.ncbi.nlm.nih.gov/gene/?term=330766 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010673 330817 Dhps http://www.ncbi.nlm.nih.gov/gene/?term=330817 Dhs mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010674 33081 Cbs http://www.ncbi.nlm.nih.gov/gene/?term=33081 "Dmel_CG1753, CBS, CG1753, DmCBS, Dmel\CG1753, dCBS " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010675 330836 Slc7a6 http://www.ncbi.nlm.nih.gov/gene/?term=330836 "AI643885, LAT-2, LAT3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010676 33085 CG32512 http://www.ncbi.nlm.nih.gov/gene/?term=33085 "Dmel_ CG15447, CG1739, Dmel\CG32512 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010677 33085 CG32512 http://www.ncbi.nlm.nih.gov/gene/?term=33085 "Dmel_ CG15447, CG1739, Dmel\CG32512 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010678 3308 HSPA4 http://www.ncbi.nlm.nih.gov/gene/?term=3308 "APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010679 3308 HSPA4 http://www.ncbi.nlm.nih.gov/gene/?term=3308 "APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010680 3308 HSPA4 http://www.ncbi.nlm.nih.gov/gene/?term=3308 "APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010681 330938 Dixdc1 http://www.ncbi.nlm.nih.gov/gene/?term=330938 "4930563F16Rik, BC048182, Ccd1, Ccd1Aalpha1L, Ccd1Abeta1L, Ccd1BalphaL, Ccd1BbetaL, Ccd1CL, mKIAA1735 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010682 330958 A730043L09Rik http://www.ncbi.nlm.nih.gov/gene/?term=330958 A730043L09 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010683 3309 HSPA5 http://www.ncbi.nlm.nih.gov/gene/?term=3309 "BIP, MIF2, GRP78, HEL-S-89n " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00010684 3309 HSPA5 http://www.ncbi.nlm.nih.gov/gene/?term=3309 "BIP, GRP78, HEL-S-89n, MIF2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010685 3309 HSPA5 http://www.ncbi.nlm.nih.gov/gene/?term=3309 "BIP, GRP78, HEL-S-89n, MIF2 " mRNA Homo sapiens 12923260 Endoplasmic reticulum T-cell line Jurkat S1 nuclease protection assays "Oligonucleotide probes were designed to hybridize with mRNAs encoding representative members of three classes of protein: soluble (GAPDH, Hsp90, and LDH), ER resident membrane (Sec61a and calnexin), and ER resident lumenal (BiP, calreticulin, and GRP94). " RLID00010686 3309 HSPA5 http://www.ncbi.nlm.nih.gov/gene/?term=3309 "BIP, GRP78, HEL-S-89n, MIF2 " mRNA Homo sapiens 12923260 Ribosome T-cell line Jurkat S1 nuclease protection assays "Using the procedures described above, the subcellular distribution of individual mRNAs in the cytosol and rough ER polysome fractions of Jurkat and J558 cells was determined. mRNAs for resident proteins of the ER lumen, including BiP, calreticulin, and GRP94, were also highly enriched on membrane-bound polysomes. " RLID00010687 3309 HSPA5 http://www.ncbi.nlm.nih.gov/gene/?term=3309 "BIP, GRP78, HEL-S-89n, MIF2 " mRNA Homo sapiens 18192611 Ribosome HeLa cell Northern blot FIGURE 2. Subcellular mRNA distribution in SRP54 knock-down HeLa cell lines. (A) Total RNA from control HeLa (H) or SRP54 (54) stable knock-down cells was analyzed by Northern blot. (B) Cell surface expression of DR4 was determined by flow cytometry using no primary antibody (control) or DR4 antibody. (C) Cells were fractionated by sequential detergent extraction into cytosol (lane C) or membrane-bound (lane M) fractions. RNA isolated from total cells (lane T) or cell fractions was analyzed by Northern blot using the probes listed in Materials and Methods. Data are collected from Figure 2. RLID00010688 3309 HSPA5 http://www.ncbi.nlm.nih.gov/gene/?term=3309 "BIP, GRP78, HEL-S-89n, MIF2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010689 3309 HSPA5 http://www.ncbi.nlm.nih.gov/gene/?term=3309 "BIP, GRP78, HEL-S-89n, MIF2 " mRNA Homo sapiens 22679391 Endoplasmic reticulum U2OS cell RT-PCR "Figure 3B: The levels of several transcripts in the ER fraction were analyzed as in (A). Measured transcripts include those encoding ER luminal proteins (BiP, Calreticulin), ER membrane proteins (Inositol-3-phosphate Receptor (IP3 Receptor), Sec61α, Trapα, and Fatty Acid Desaturase 3 (FADS3)), a Golgi protein (Mannosidase 2A (Man2A)), plasma membrane proteins (Integrin β1, and Transferrin Receptor (Tf Receptor)), and a secreted protein (Interleukin 7 (IL7)). All measurements were standardized to the level of mRNA in the ER fraction from control cells. Data are collected from Figure 3B. " RLID00010690 330 BIRC3 http://www.ncbi.nlm.nih.gov/gene/?term=330 "AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010691 331003 4933400C23Rik http://www.ncbi.nlm.nih.gov/gene/?term=331003 4933400C23 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010692 331021 9630017O17 http://www.ncbi.nlm.nih.gov/gene/?term=331021 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010693 331026 Gmppb http://www.ncbi.nlm.nih.gov/gene/?term=331026 "AI317178, E430010H19 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010694 33127 Cyp6t1 http://www.ncbi.nlm.nih.gov/gene/?term=33127 "Dmel_CG1644, 6t1, CG1644, Dmel\CG1644 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010695 33128 CG14621 http://www.ncbi.nlm.nih.gov/gene/?term=33128 "Dmel_ Dmel\CG14621, Slc35e1, lincRNA.1043 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010696 33128 CG14621 http://www.ncbi.nlm.nih.gov/gene/?term=33128 "Dmel_ Dmel\CG14621, Slc35e1, lincRNA.1043 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010697 33129 CG14615 http://www.ncbi.nlm.nih.gov/gene/?term=33129 Dmel_ Dmel\CG14615 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010698 3312 HSPA8 http://www.ncbi.nlm.nih.gov/gene/?term=3312 "HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010699 3312 HSPA8 http://www.ncbi.nlm.nih.gov/gene/?term=3312 "HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010700 3312 HSPA8 http://www.ncbi.nlm.nih.gov/gene/?term=3312 "HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010701 3312 HSPA8 http://www.ncbi.nlm.nih.gov/gene/?term=3312 "HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010702 3312 HSPA8 http://www.ncbi.nlm.nih.gov/gene/?term=3312 "HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010703 33132 Usp2 http://www.ncbi.nlm.nih.gov/gene/?term=33132 "Dmel_CG14619, CG14619, Dmel\CG14619, Q9VR54 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010704 33132 Usp2 http://www.ncbi.nlm.nih.gov/gene/?term=33132 "Dmel_CG14619, CG14619, Dmel\CG14619, Q9VR54 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010705 33134 CG14618 http://www.ncbi.nlm.nih.gov/gene/?term=33134 Dmel_ Dmel\CG14618 mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010706 33135 CG12576 http://www.ncbi.nlm.nih.gov/gene/?term=33135 "Dmel_ Dmel\CG12576, anon-WO0140519.40 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010707 33135 CG12576 http://www.ncbi.nlm.nih.gov/gene/?term=33135 "Dmel_ Dmel\CG12576, anon-WO0140519.40 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010708 33135 CG12576 http://www.ncbi.nlm.nih.gov/gene/?term=33135 "Dmel_ Dmel\CG12576, anon-WO0140519.40 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010709 33136 Cp110 http://www.ncbi.nlm.nih.gov/gene/?term=33136 "Dmel_CG14617, CG14617, CG32501, CP110, DCP110, Dmel\CG14617 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010710 3313 HSPA9 http://www.ncbi.nlm.nih.gov/gene/?term=3313 "CRP40, CSA, EVPLS, GRP-75, GRP75, HEL-S-124mB, MOT, MOT2, MTHSP75, PBP74, SAAN, SIDBA4, HSPA9 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010711 331401 Thoc2 http://www.ncbi.nlm.nih.gov/gene/?term=331401 "6330441O12Rik, D130005M13Rik, Gm1139, Gm1793, Tho2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010712 331416 Gm773 http://www.ncbi.nlm.nih.gov/gene/?term=331416 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010713 331480 Gm5126 http://www.ncbi.nlm.nih.gov/gene/?term=331480 EG331480 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010714 3315 HSPB1 http://www.ncbi.nlm.nih.gov/gene/?term=3315 "CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010715 3315 HSPB1 http://www.ncbi.nlm.nih.gov/gene/?term=3315 "CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010716 3315 HSPB1 http://www.ncbi.nlm.nih.gov/gene/?term=3315 "CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010717 33162 galectin http://www.ncbi.nlm.nih.gov/gene/?term=33162 "Dmel_CG11372, CG11372, Dmel\CG11372, Dmgal " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010718 33172 Gs1 http://www.ncbi.nlm.nih.gov/gene/?term=33172 "Dmel_CG2718, CG2718, Dmel\CG2718, GS1, GSI, GsI, fs(2)P52, fs(2)throng, gs-m, gsI, l(2)21Bc, mt-gs, thg " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010719 33180 CG3436 http://www.ncbi.nlm.nih.gov/gene/?term=33180 Dmel_ Dmel\CG3436 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010720 33196 smo http://www.ncbi.nlm.nih.gov/gene/?term=33196 "Dmel_CG11561, CG11561, Dmel\CG11561, SMO, Smo, dSmo " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00010721 331 XIAP http://www.ncbi.nlm.nih.gov/gene/?term=331 "API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010722 331 XIAP http://www.ncbi.nlm.nih.gov/gene/?term=331 "API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010723 331 XIAP http://www.ncbi.nlm.nih.gov/gene/?term=331 "API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010724 331 XIAP http://www.ncbi.nlm.nih.gov/gene/?term=331 "API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010725 331 XIAP http://www.ncbi.nlm.nih.gov/gene/?term=331 "API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010726 33203 Pi3K21B http://www.ncbi.nlm.nih.gov/gene/?term=33203 "Dmel_CG2699, CG2699, Dmel\CG2699, Dp60, PI(3)K, PI3K, PI3K-p60, PI3K21B, PI[[3]]K|p60, Pi3Kp60, dP60, dPI3K, droPIK57, p60 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010727 3320 HSP90AA1 http://www.ncbi.nlm.nih.gov/gene/?term=3320 "EL52, HSPN, LAP2, HSP86, HSPC1, HSPCA, Hsp89, Hsp90, LAP-2, HSP89A, HSP90A, HSP90N, HSPCAL1, HSPCAL4, HEL-S-65p " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00010728 3320 HSP90AA1 http://www.ncbi.nlm.nih.gov/gene/?term=3320 "EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010729 3320 HSP90AA1 http://www.ncbi.nlm.nih.gov/gene/?term=3320 "EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2 " mRNA Homo sapiens 12923260 Ribosome T-cell line Jurkat S1 nuclease protection assays "Oligonucleotide probes were designed to hybridize with mRNAs encoding representative members of three classes of protein: soluble (GAPDH, Hsp90, and LDH), ER resident membrane (Sec61a and calnexin), and ER resident lumenal (BiP, calreticulin, and GRP94). " RLID00010730 3320 HSP90AA1 http://www.ncbi.nlm.nih.gov/gene/?term=3320 "EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2 " mRNA Homo sapiens 18192611 Ribosome HeLa cell Northern blot FIGURE 2. Subcellular mRNA distribution in SRP54 knock-down HeLa cell lines. (A) Total RNA from control HeLa (H) or SRP54 (54) stable knock-down cells was analyzed by Northern blot. (B) Cell surface expression of DR4 was determined by flow cytometry using no primary antibody (control) or DR4 antibody. (C) Cells were fractionated by sequential detergent extraction into cytosol (lane C) or membrane-bound (lane M) fractions. RNA isolated from total cells (lane T) or cell fractions was analyzed by Northern blot using the probes listed in Materials and Methods. Data are collected from Figure 2. RLID00010731 33211 AP-2alpha http://www.ncbi.nlm.nih.gov/gene/?term=33211 "Dmel_CG4260, AP-2, AP2, Alpha-Adaptin, CG31654, CG4260, D-Ada, D-alphaAda, Dmel\CG4260, MENE (2L)-A, MENE(2L)-A, ada, alpha, alpha-Ada, alpha-Adaptin, alpha-ada, alpha-adaptin, apl3, cg4260, dAP-2a, l(2)06694, l(2)SH0460, l(2)SH2 0460 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010732 33218 ex http://www.ncbi.nlm.nih.gov/gene/?term=33218 "Dmel_CG4114, 1270, CG4114, Dmel\CG4114, Ex, Expanded, brl, l(2)01270, l(2)ey " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010733 3321 IGSF3 http://www.ncbi.nlm.nih.gov/gene/?term=3321 "EWI-3, LCDD, V8 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010734 33224 cbt http://www.ncbi.nlm.nih.gov/gene/?term=33224 "Dmel_CG4427, CG4427, Cabot, Cabut, Dmel\CG4427, EP(2)2237, EP2237, dTIEG " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00010735 33234 Nle http://www.ncbi.nlm.nih.gov/gene/?term=33234 "Dmel_CG2863, CG2863, Dmel\CG2863, anon-WO0026364, l(2)k13714 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010736 33248 GABA-B-R3 http://www.ncbi.nlm.nih.gov/gene/?term=33248 "Dmel_CG3022, CG3022, D-GABA[[B]]R3, D-Gaba3, Dmel\CG3022, GABA B R3, GABA[[B]]-R3, GABA[[B]]R3, GB3, anon-WO0170980.13, anon-WO0170980.14 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010737 33252 CG3544 http://www.ncbi.nlm.nih.gov/gene/?term=33252 Dmel_ Dmel\CG3544 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010738 33262 dock http://www.ncbi.nlm.nih.gov/gene/?term=33262 "Dmel_CG3727, CG3727, DOCK, Dm0447, Dmel\CG3727, Dock, Nck, dck, doc, l(2)04723 " mRNA Drosophila melanogaster 17923096 Nucleus Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00010739 3326 HSP90AB1 http://www.ncbi.nlm.nih.gov/gene/?term=3326 "D6S182, HSP84, HSP90B, HSPC2, HSPCB " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010740 3326 HSP90AB1 http://www.ncbi.nlm.nih.gov/gene/?term=3326 "D6S182, HSP84, HSP90B, HSPC2, HSPCB " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010741 33277 IA-2 http://www.ncbi.nlm.nih.gov/gene/?term=33277 "Dmel_CG31795, CG11344, CG31795, CG4355, Dmel\CG31795, R-PTPX/1A2, anon-WO0153538.69, ia2 " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00010742 33284 CG4629 http://www.ncbi.nlm.nih.gov/gene/?term=33284 "Dmel_ Dmel\CG4629, anon-WO0257455.15 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010743 33288 Pino http://www.ncbi.nlm.nih.gov/gene/?term=33288 "Dmel_CG4710, CG4710, Dmel\CG4710, anon-WO0118547.131, smi21F " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010744 3329 HSPD1 http://www.ncbi.nlm.nih.gov/gene/?term=3329 "CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010745 332 BIRC5 http://www.ncbi.nlm.nih.gov/gene/?term=332 "API4, EPR-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010746 332 BIRC5 http://www.ncbi.nlm.nih.gov/gene/?term=332 "API4, EPR-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010747 333329 Cngb1 http://www.ncbi.nlm.nih.gov/gene/?term=333329 "Cngb1b, Gm1959 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010748 3336 HSPE1 http://www.ncbi.nlm.nih.gov/gene/?term=3336 "CPN10, EPF, GROES, HSP10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010749 333789 N4bp2 http://www.ncbi.nlm.nih.gov/gene/?term=333789 "B3bp, E430014I16, Gm1791, Gm868 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010750 3337 DNAJB1 http://www.ncbi.nlm.nih.gov/gene/?term=3337 "HSPF1, Hdj1, Hsp40, RSPH16B, Sis1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010751 3337 DNAJB1 http://www.ncbi.nlm.nih.gov/gene/?term=3337 "HSPF1, Hdj1, Hsp40, RSPH16B, Sis1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010752 3337 DNAJB1 http://www.ncbi.nlm.nih.gov/gene/?term=3337 "HSPF1, Hdj1, Hsp40, RSPH16B, Sis1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010753 3338 DNAJC4 http://www.ncbi.nlm.nih.gov/gene/?term=3338 "DANJC4, HSPF2, MCG18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010754 333926 PPM1J http://www.ncbi.nlm.nih.gov/gene/?term=333926 "PP2CZ, PP2Czeta, PPP2CZ " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010755 33392 aop http://www.ncbi.nlm.nih.gov/gene/?term=33392 "Dmel_CG3166, AOP, Aop, Aop/Yan, CG3166, DROYANET, DROYANETSB, Dmel\CG3166, SK2-1, YAN, Yan/yan, fus6, pok, yan, yan/pok, aop " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010756 333932 HIST2H3A http://www.ncbi.nlm.nih.gov/gene/?term=333932 "H3/n, H3/o " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010757 333932 HIST2H3A http://www.ncbi.nlm.nih.gov/gene/?term=333932 "H3/n, H3/o " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010758 3339 HSPG2 http://www.ncbi.nlm.nih.gov/gene/?term=3339 "HSPG, PLC, PRCAN, SJA, SJS, SJS1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010759 3339 HSPG2 http://www.ncbi.nlm.nih.gov/gene/?term=3339 "HSPG, PLC, PRCAN, SJA, SJS, SJS1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010760 333 APLP1 http://www.ncbi.nlm.nih.gov/gene/?term=333 APLP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010761 3340 NDST1 http://www.ncbi.nlm.nih.gov/gene/?term=3340 "HSST, MRT46, NST1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010762 33418 Rab5 http://www.ncbi.nlm.nih.gov/gene/?term=33418 "Dmel_CG3664, AAF51265, BAA88244, CG3664, D Dm Rab5, DmRab5, Dmel\CG3664, Drab5, RAB5, RAB5a, Rab, Rab-5, dRab5, drab5, l(2)k08232, rab5 " mRNA Drosophila melanogaster 18272590 Germ plasm Oocyte - "Here we show that Rabenosyn-5 (Rbsn-5), a Rab5 effector protein required for the early endocytic pathway, is crucial for pole plasm assembly. rbsn-5(-) oocytes fail to maintain microtubule polarity, which secondarily disrupts osk RNA localization. " RLID00010763 33423 Atxn7 http://www.ncbi.nlm.nih.gov/gene/?term=33423 "Dmel_CG9866, CG9866, Dmel\CG9866 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010764 33432 dpp http://www.ncbi.nlm.nih.gov/gene/?term=33432 "Dmel_CG9885, BMP, CG9885, DPP, DPP-C, Dm-DPP, Dmel\CG9885, Dpp, Hin-d, M(2)23AB, M(2)LS1, TGF-b, TGF-beta, TGFbeta, Tg, blk, ho, l(2)10638, l(2)22Fa, l(2)k17036, shv " mRNA Drosophila melanogaster 15852043 Centrosome Neuroblasts - "Dpp mRNA (red) localization to the centrosome in the MACROMERES of an eight-cell Ilyanassa obsoleta embryo (microtubules, green; DNA, blue). The mRNA moves from the centrosome to the adjacent cortex during prophase, and is asymmetrically segregated into the second quartet of MICROMERES. " RLID00010765 334375 buc http://www.ncbi.nlm.nih.gov/gene/?term=334375 "fi43g04, wu:fi43g04 " mRNA Danio rerio 23626739 Mitochondrion Oocyte Microscopy "In contrast to Xenopus Xvelo1, buc RNA is localised to the Balbiani body at early stages and to the animal pole at late stages, before becoming unlocalised in later oogenesis. " RLID00010766 3344 FOXN2 http://www.ncbi.nlm.nih.gov/gene/?term=3344 HTLF mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010767 3344 FOXN2 http://www.ncbi.nlm.nih.gov/gene/?term=3344 HTLF mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010768 33460 Cwc25 http://www.ncbi.nlm.nih.gov/gene/?term=33460 "Dmel_CG2843, CG2843, CWC25, Dmel\CG2843 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010769 3346167 btsz http://www.ncbi.nlm.nih.gov/gene/?term=3346167 "Dmel_CG44012, BcDNA:GH06647, Btsz, CG14858, CG17304, CG18280, CG31306, CG33555, CG44012, CG7343, Dmel\CG44012, Dmel_CG17304, Dmel_CG33555, Granulophilin, l(3)10418 " mRNA Drosophila melanogaster 14581614 Apical Epithelial cell In situ hybridization "In epithelial cells large enough to discern cell polarity, btsz mRNA clearly localizes to the apical plasma membrane. " RLID00010770 33466 CG3077 http://www.ncbi.nlm.nih.gov/gene/?term=33466 "Dmel_ DmSNX21, Dmel\CG3077 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010771 334 APLP2 http://www.ncbi.nlm.nih.gov/gene/?term=334 "APLP-2, APPH, APPL2, CDEBP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010772 334 APLP2 http://www.ncbi.nlm.nih.gov/gene/?term=334 "APLP-2, APPH, APPL2, CDEBP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010773 33507 okr http://www.ncbi.nlm.nih.gov/gene/?term=33507 "Dmel_CG3736, CG3736, DhR54, DmRAD54, DmRad54, Dmel\CG3736, Dmrad54, Okr, RAD54, RAD54L, Rad54, Ras54, rad54 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010774 33526 toc http://www.ncbi.nlm.nih.gov/gene/?term=33526 "Dmel_CG9660, BA34, BcDNA:LD27161, CG9660, Dmel\CG9660, Toc, l(2)01361, l(2)05527, l(2)K08224, l(2)k08224 " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010775 33526 toc http://www.ncbi.nlm.nih.gov/gene/?term=33526 "Dmel_CG9660, BA34, BcDNA:LD27161, CG9660, Dmel\CG9660, Toc, l(2)01361, l(2)05527, l(2)K08224, l(2)k08224 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010776 33526 toc http://www.ncbi.nlm.nih.gov/gene/?term=33526 "Dmel_CG9660, BA34, BcDNA:LD27161, CG9660, Dmel\CG9660, Toc, l(2)01361, l(2)05527, l(2)K08224, l(2)k08224 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010777 3354888 rl http://www.ncbi.nlm.nih.gov/gene/?term=3354888 "Dmel_CG12559, 12559, BcDNA:RE08694, CG12559, CG18732, CT34260, CT39192, D-ERK, DERK, DERK-A, DmERK-A, DmERKA, DmErk, DmMAPK, Dmel\CG12559, DpERK, DpErk, Dsor2, E(sina)7, EC2-1, EK2-1, ERK, ERK-A, ERKA, ERKa, EY2-2, Erk, Erk/Map kinase, Erk1, ErkA, GroupII, MAP-k, MAPK, MapK, Mapk, RL, Rl, SEM, SR2-1, Sem, Su(Raf)2B, dERK, dm-dpERK, dp-ERK, dpERK, dpERK1, dpERk, dpErk, dpMAPK, erk, l(2)41Ac, l(2R)EMS45-39, mapk, pERK, pMAPK, pMapK/ERK, rl/MAPK, rll, sem, rl " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010778 3354896 vtd http://www.ncbi.nlm.nih.gov/gene/?term=3354896 "Dmel_CG17436, 80Fh, CG17436, CG40222, DRAD21, DRad21, DmRAD21, Dmel\CG17436, Drad21, RAD21, Rad21, Rad21/Scc1, Scc1, VTD, dRad21, drad21, l(3)80Fh, l(3)Lh3, l3, lethal 3, rad21, scc1 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010779 3354919 Dbp80 http://www.ncbi.nlm.nih.gov/gene/?term=3354919 "Dmel_CG17023, BcDNA:RE44177, CG17023, DBP80, DmDbp80, Dmel\CG17023, HEL80, Hel40, Hel80, hel-40, mdcds_36124 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010780 3354919 Dbp80 http://www.ncbi.nlm.nih.gov/gene/?term=3354919 "Dmel_CG17023, BcDNA:RE44177, CG17023, DBP80, DmDbp80, Dmel\CG17023, HEL80, Hel40, Hel80, hel-40, mdcds_36124 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010781 3354977 MED21 http://www.ncbi.nlm.nih.gov/gene/?term=3354977 "Dmel_CG17397, CG17397, CG40364, Dmel\CG17397, Med21, Trap19, dSRB7, dTRAP19, p18 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010782 3354988 CG17163 http://www.ncbi.nlm.nih.gov/gene/?term=3354988 Dmel_ Dmel\CG17163 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010783 3354992 zyd http://www.ncbi.nlm.nih.gov/gene/?term=3354992 "Dmel_CG2893, BEST:CK02262, CG2893, CG40147, CK02262, Dmel\CG2893 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010784 3354996 CG17168 http://www.ncbi.nlm.nih.gov/gene/?term=3354996 Dmel_ Dmel\CG17168 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010785 3355011 CG17683 http://www.ncbi.nlm.nih.gov/gene/?term=3355011 "Dmel_ Dmel\CG17683, NAR1p, NC37, NC38, NC70, l(2)NC37, l(2)NC38, l(2)NC70 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010786 3355041 eIF-4B http://www.ncbi.nlm.nih.gov/gene/?term=3355041 "Dmel_CG10837, CG10837, Dm-eIF4B, Dmel\CG10837, EIF-4B, Eif4B-L, eIF-4B-S, eIF-4b, eIF4B, eIF4B-L, eIF4B-S, eIf4b, eIF-4B " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010787 3355072 CG41099 http://www.ncbi.nlm.nih.gov/gene/?term=3355072 "Dmel_ BEST:GM10035, CG17416, CG17419, Dmel\CG41099, GM10035 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010788 3355079 CG40045 http://www.ncbi.nlm.nih.gov/gene/?term=3355079 "Dmel_ BcDNA:RE63412, Dmel\CG40045 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010789 3355094 CG12567 http://www.ncbi.nlm.nih.gov/gene/?term=3355094 Dmel_ Dmel\CG12567 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010790 3355109 Parp http://www.ncbi.nlm.nih.gov/gene/?term=3355109 "Dmel_CG40411, BEST:LD21673, CG17685, CG17696, CG17718, CG40411, D.PARP, Dm.pARTa, Dmel\CG40411, LD21673.3prime, PARP, PARP-1, PARP11, dPARP, dmparp, parp, Parp " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010791 3355123 CG40006 http://www.ncbi.nlm.nih.gov/gene/?term=3355123 "Dmel_ BcDNA:RE68569, Dmel\CG40006 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010792 3355123 CG40006 http://www.ncbi.nlm.nih.gov/gene/?term=3355123 "Dmel_ BcDNA:RE68569, Dmel\CG40006 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010793 3355125 CG17490 http://www.ncbi.nlm.nih.gov/gene/?term=3355125 Dmel_ Dmel\CG17490 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010794 3355127 Slmap http://www.ncbi.nlm.nih.gov/gene/?term=3355127 "Dmel_CG17494, CG17494, Dmel\CG17494 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010795 3355129 CG17715 http://www.ncbi.nlm.nih.gov/gene/?term=3355129 "Dmel_ BcDNA:RE07178, BcDNA:RE63764, CG18603, Dmel\CG17715 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010796 3355130 lt http://www.ncbi.nlm.nih.gov/gene/?term=3355130 "Dmel_CG18028, CG18028, Dm-lt(het), Dmel\CG18028, Lt, Vps41, l(2)40Fb, vps41 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010797 3355145 CG12547 http://www.ncbi.nlm.nih.gov/gene/?term=3355145 "Dmel_ CG40277, Dmel\CG12547, anon-EST:Posey268 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010798 3356 HTR2A http://www.ncbi.nlm.nih.gov/gene/?term=3356 "5-HT2A, HTR2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010799 33583 odd http://www.ncbi.nlm.nih.gov/gene/?term=33583 "Dmel_CG3851, CG3851, Dmel\CG3851, ODD, Odd, l(2)01863, ods " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00010800 3359 HTR3A http://www.ncbi.nlm.nih.gov/gene/?term=3359 "5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010801 335 APOA1 http://www.ncbi.nlm.nih.gov/gene/?term=335 apo(a) mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010802 3361053 SPCTRNAILE.09 http://www.ncbi.nlm.nih.gov/gene/?term=3361053 SPCTRNAILE.09 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPCTRNAILE.09 RLID00010803 3361065 SPCTRNAALA.12 http://www.ncbi.nlm.nih.gov/gene/?term=3361065 SPCTRNAALA.12 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPCTRNAALA.12 RLID00010804 3361195 SPBTRNAGLN.01 http://www.ncbi.nlm.nih.gov/gene/?term=3361195 SPBTRNAGLN.01 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNAGLN.01 RLID00010805 3361196 SPBTRNAGLN.02 http://www.ncbi.nlm.nih.gov/gene/?term=3361196 SPBTRNAGLN.02 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNAGLN.02 RLID00010806 3361200 snu4 http://www.ncbi.nlm.nih.gov/gene/?term=3361200 SPSNRNA.04 snRNA Saccharomyces cerevisiae 25361970 Nucleolus - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPSNRNA.04 RLID00010807 3361228 SPBTRNAVAL.08 http://www.ncbi.nlm.nih.gov/gene/?term=3361228 SPBTRNAVAL.08 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNAVAL.08 RLID00010808 3361229 SPBTRNAGLU.07 http://www.ncbi.nlm.nih.gov/gene/?term=3361229 SPBTRNAGLU.07 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNAGLU.07 RLID00010809 3361236 SPBTRNALEU.07 http://www.ncbi.nlm.nih.gov/gene/?term=3361236 SPBTRNALEU.07 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNALEU.07 RLID00010810 3361238 SPBTRNAVAL.07 http://www.ncbi.nlm.nih.gov/gene/?term=3361238 SPBTRNAVAL.07 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNAVAL.07 RLID00010811 3361240 SPBTRNAVAL.06 http://www.ncbi.nlm.nih.gov/gene/?term=3361240 SPBTRNAVAL.06 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNAVAL.06 RLID00010812 3361244 SPBTRNAGLU.06 http://www.ncbi.nlm.nih.gov/gene/?term=3361244 SPBTRNAGLU.06 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNAGLU.06 RLID00010813 3361246 SPBTRNAVAL.05 http://www.ncbi.nlm.nih.gov/gene/?term=3361246 SPBTRNAVAL.05 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNAVAL.05 RLID00010814 3361251 SPBTRNALEU.06 http://www.ncbi.nlm.nih.gov/gene/?term=3361251 SPBTRNALEU.06 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNALEU.06 RLID00010815 3361264 SPBTRNALEU.05 http://www.ncbi.nlm.nih.gov/gene/?term=3361264 SPBTRNALEU.05 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNALEU.05 RLID00010816 3361279 SPBTRNAGLN.03 http://www.ncbi.nlm.nih.gov/gene/?term=3361279 SPBTRNAGLN.03 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNAGLN.03 RLID00010817 3361280 SPBTRNAGLN.04 http://www.ncbi.nlm.nih.gov/gene/?term=3361280 SPBTRNAGLN.04 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNAGLN.04 RLID00010818 3361282 SPBTRNAGLU.05 http://www.ncbi.nlm.nih.gov/gene/?term=3361282 SPBTRNAGLU.05 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNAGLU.05 RLID00010819 3361302 SPBTRNAPHE.03 http://www.ncbi.nlm.nih.gov/gene/?term=3361302 SPBTRNAPHE.03 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNAPHE.03 RLID00010820 3361311 SPBTRNALEU.08 http://www.ncbi.nlm.nih.gov/gene/?term=3361311 SPBTRNALEU.08 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNALEU.08 RLID00010821 3361317 snu1 http://www.ncbi.nlm.nih.gov/gene/?term=3361317 SPSNRNA.01 snRNA Saccharomyces cerevisiae 25361970 Nucleolus - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPSNRNA.01 RLID00010822 3361326 SPBTRNALEU.09 http://www.ncbi.nlm.nih.gov/gene/?term=3361326 SPBTRNALEU.09 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNALEU.09 RLID00010823 3361328 snu5 http://www.ncbi.nlm.nih.gov/gene/?term=3361328 SPSNRNA.05 snRNA Saccharomyces cerevisiae 25361970 Nucleolus - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPSNRNA.05 RLID00010824 3361347 SPBTRNALEU.10 http://www.ncbi.nlm.nih.gov/gene/?term=3361347 SPBTRNALEU.10 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNALEU.10 RLID00010825 3361355 SPBTRNAGLU.08 http://www.ncbi.nlm.nih.gov/gene/?term=3361355 SPBTRNAGLU.08 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPBTRNAGLU.08 RLID00010826 3361379 SPATRNAPRO.01 http://www.ncbi.nlm.nih.gov/gene/?term=3361379 SPATRNAPRO.01 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPATRNAPRO.01 RLID00010827 3361382 sno52 http://www.ncbi.nlm.nih.gov/gene/?term=3361382 SPSNORNA.29 snoRNA Saccharomyces cerevisiae 25361970 Nucleolus - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPSNORNA.29 RLID00010828 3361404 SPATRNAASP.01 http://www.ncbi.nlm.nih.gov/gene/?term=3361404 SPATRNAASP.01 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPATRNAASP.01 RLID00010829 3361447 SPATRNAARG.02 http://www.ncbi.nlm.nih.gov/gene/?term=3361447 SPATRNAARG.02 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPATRNAARG.02 RLID00010830 3361463 SPATRNAARG.01 http://www.ncbi.nlm.nih.gov/gene/?term=3361463 SPATRNAARG.01 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPATRNAARG.01 RLID00010831 3361522 snu3 http://www.ncbi.nlm.nih.gov/gene/?term=3361522 SPSNRNA.03 snoRNA Saccharomyces cerevisiae 25361970 Nucleolus - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPSNRNA.03 RLID00010832 3361546 SPATRNAPRO.03 http://www.ncbi.nlm.nih.gov/gene/?term=3361546 SPATRNAPRO.03 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPATRNAPRO.03 RLID00010833 3361551 SPATRNAARG.03 http://www.ncbi.nlm.nih.gov/gene/?term=3361551 SPATRNAARG.03 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPATRNAARG.03 RLID00010834 3361559 SPATRNAASP.02 http://www.ncbi.nlm.nih.gov/gene/?term=3361559 SPATRNAASP.02 tRNA Saccharomyces cerevisiae 25361970 Cytoplasm - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPATRNAASP.02 RLID00010835 3361571 snu2 http://www.ncbi.nlm.nih.gov/gene/?term=3361571 SPSNRNA.02 snRNA Saccharomyces cerevisiae 25361970 Nucleolus - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPSNRNA.02 RLID00010836 3361572 snu6 http://www.ncbi.nlm.nih.gov/gene/?term=3361572 SPSNRNA.06 snRNA Saccharomyces cerevisiae 25361970 Nucleolus - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPSNRNA.06 RLID00010837 33628 CG3702 http://www.ncbi.nlm.nih.gov/gene/?term=33628 "Dmel_ Dmel\CG3702, cg3702 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010838 33628 CG3702 http://www.ncbi.nlm.nih.gov/gene/?term=33628 "Dmel_ Dmel\CG3702, cg3702 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010839 33629 RpL40 http://www.ncbi.nlm.nih.gov/gene/?term=33629 "Dmel_CG2960, BcDNA:RE10554, CEP52, CG2960, DUb52, Dmel\CG2960, Dub52, Rpl40, Ub52, Ubi-f, Ubi-f52, Ubiq " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010840 33629 RpL40 http://www.ncbi.nlm.nih.gov/gene/?term=33629 "Dmel_CG2960, BcDNA:RE10554, CEP52, CG2960, DUb52, Dmel\CG2960, Dub52, Rpl40, Ub52, Ubi-f, Ubi-f52, Ubiq " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010841 3362 HTR6 http://www.ncbi.nlm.nih.gov/gene/?term=3362 "5-HT6, 5-HT6R " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010842 33635 bdl http://www.ncbi.nlm.nih.gov/gene/?term=33635 "Dmel_CG16857, BcDNA:GH11322, CG16857, CT35491, Dmel\CG16857, GH11322 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010843 33638 Traf4 http://www.ncbi.nlm.nih.gov/gene/?term=33638 "Dmel_CG3048, CG3048, DTRAF, DTRAF1, Dmel\CG3048, TRAF, TRAF1, TRAF4, Traf1, dTRAF, dTRAF1, dTraf1, dTraf4, dtraf1, traf-4, traf1, traf4 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010844 33652 CG15440 http://www.ncbi.nlm.nih.gov/gene/?term=33652 "Dmel_ Dmel\CG15440, Secp43, cg15440 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010845 33710 Trip1 http://www.ncbi.nlm.nih.gov/gene/?term=33710 "Dmel_CG8882, CG8882, DmTRIP, Dmel\CG8882, eIF-3beta, eIF3-S2, eIF3i " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010846 33710 Trip1 http://www.ncbi.nlm.nih.gov/gene/?term=33710 "Dmel_CG8882, CG8882, DmTRIP, Dmel\CG8882, eIF-3beta, eIF3-S2, eIF3i " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010847 3371 TNC http://www.ncbi.nlm.nih.gov/gene/?term=3371 "150-225, DFNA56, GMEM, GP, HXB, JI, TN, TN-C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010848 3371 TNC http://www.ncbi.nlm.nih.gov/gene/?term=3371 "150-225, DFNA56, GMEM, GP, HXB, JI, TN, TN-C " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010849 33721 Rtnl1 http://www.ncbi.nlm.nih.gov/gene/?term=33721 "Dmel_CG33113, 142893_at, CG18623, CG33113, CG8895, Dmel\CG33113, G9, Retl1, Rtnl-1, rtnl1 " mRNA Drosophila melanogaster 25838129 Basal Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010850 33726 vkg http://www.ncbi.nlm.nih.gov/gene/?term=33726 "Dmel_CG16858, 1209, 6072, CG16858, CT25584, Coll IValpha2, DmColA2, Dmel\CG16858, Vkg, VkgC, alpha(IV)2/vkg, col4a2, coll-IV, coll. IV, collagen-IV, l(2)01209 " mRNA Drosophila melanogaster 25838129 Basal Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010851 33726 vkg http://www.ncbi.nlm.nih.gov/gene/?term=33726 "Dmel_CG16858, 1209, 6072, CG16858, CT25584, Coll IValpha2, DmColA2, Dmel\CG16858, Vkg, VkgC, alpha(IV)2/vkg, col4a2, coll-IV, coll. IV, collagen-IV, l(2)01209 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010852 33726 vkg http://www.ncbi.nlm.nih.gov/gene/?term=33726 "Dmel_CG16858, 1209, 6072, CG16858, CT25584, Coll IValpha2, DmColA2, Dmel\CG16858, Vkg, VkgC, alpha(IV)2/vkg, col4a2, coll-IV, coll. IV, collagen-IV, l(2)01209 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010853 33739 qtc http://www.ncbi.nlm.nih.gov/gene/?term=33739 "Dmel_CG14039, CG14039, Dmel\CG14039 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010854 3373 HYAL1 http://www.ncbi.nlm.nih.gov/gene/?term=3373 "HYAL-1, LUCA1, MPS9, NAT6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010855 33757 Bsg25D http://www.ncbi.nlm.nih.gov/gene/?term=33757 "Dmel_CG14025, CG14025, Dmel\CG14025, brg25D, bsg25D, bsq25D " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010856 33757 Bsg25D http://www.ncbi.nlm.nih.gov/gene/?term=33757 "Dmel_CG14025, CG14025, Dmel\CG14025, brg25D, bsg25D, bsq25D " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010857 33758 Bub1 http://www.ncbi.nlm.nih.gov/gene/?term=33758 "Dmel_CG14030, BUB1, BUB1-like, BubR1, BubRI, CG14030, CG14030/Bub1, Dmel\CG14030, bub1 " mRNA Drosophila melanogaster 17923096 Posterior Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00010858 3375 IAPP http://www.ncbi.nlm.nih.gov/gene/?term=3375 "DAP, IAP " mRNA Homo sapiens 21525359 Cytoplasm 293 cell qRT-PCR "Rather, the removal of P bodies shifted IAP mRNA from nonpolysomal to polysomal fractions. Although IAP mRNA localized to P bodies, Gag was targeted to the endoplasmic reticulum (ER), from which IAP buds. Indeed, we observed increased levels of IAP mRNA and Gag upon P-body disruption. " RLID00010859 3375 IAPP http://www.ncbi.nlm.nih.gov/gene/?term=3375 "DAP, IAP " mRNA Homo sapiens 21525359 Ribosome 293 cell qRT-PCR "Rather, the removal of P bodies shifted IAP mRNA from nonpolysomal to polysomal fractions. Although IAP mRNA localized to P bodies, Gag was targeted to the endoplasmic reticulum (ER), from which IAP buds. Indeed, we observed increased levels of IAP mRNA and Gag upon P-body disruption. " RLID00010860 3376 IARS http://www.ncbi.nlm.nih.gov/gene/?term=3376 "IARS1, ILERS, ILRS, IRS, PRO0785 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010861 3376 IARS http://www.ncbi.nlm.nih.gov/gene/?term=3376 "IARS1, ILERS, ILRS, IRS, PRO0785 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010862 3376 IARS http://www.ncbi.nlm.nih.gov/gene/?term=3376 "IARS1, ILERS, ILRS, IRS, PRO0785 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010863 33770 mid http://www.ncbi.nlm.nih.gov/gene/?term=33770 "Dmel_CG6634, CG6634, Dmel\CG6634, H15r, H15r/nmr2, Mid(H15), TBX20, extra, los, nmr2 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010864 33770 mid http://www.ncbi.nlm.nih.gov/gene/?term=33770 "Dmel_CG6634, CG6634, Dmel\CG6634, H15r, H15r/nmr2, Mid(H15), TBX20, extra, los, nmr2 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010865 33778 Cap-D3 http://www.ncbi.nlm.nih.gov/gene/?term=33778 "Dmel_CG31989, BcDNA:RE74832, CAP-D2, CAP-D3, CG14019, CG31989, CG6922, CapD3, Dmel\CG31989, cap-D3, dCap-D3 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010866 337867 UBAC2 http://www.ncbi.nlm.nih.gov/gene/?term=337867 PHGDHL1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010867 337 APOA4 http://www.ncbi.nlm.nih.gov/gene/?term=337 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010868 33803 CG11147 http://www.ncbi.nlm.nih.gov/gene/?term=33803 Dmel_ Dmel\CG11147 mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010869 33803 CG11147 http://www.ncbi.nlm.nih.gov/gene/?term=33803 Dmel_ Dmel\CG11147 mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010870 33814 rau http://www.ncbi.nlm.nih.gov/gene/?term=33814 "Dmel_CG8965, CG8965, Dmel\CG8965 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010871 33814 rau http://www.ncbi.nlm.nih.gov/gene/?term=33814 "Dmel_CG8965, CG8965, Dmel\CG8965 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010872 3382 ICA1 http://www.ncbi.nlm.nih.gov/gene/?term=3382 "ICA69, ICAp69 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010873 338337 Cog3 http://www.ncbi.nlm.nih.gov/gene/?term=338337 E430004N23 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010874 33834 chic http://www.ncbi.nlm.nih.gov/gene/?term=33834 "Dmel_CG9553, CG9553, Chi, Chic, D88, Dmel\CG9553, GH4, chi, l(2)27/7, profilin, sand " mRNA Drosophila melanogaster 24656828 Axon Neuron In situ hybridization "Finally, we demonstrate that profilin mRNA is a direct and functional target of Imp that localizes to axons and controls axonal regrowth. " RLID00010875 33834 chic http://www.ncbi.nlm.nih.gov/gene/?term=33834 "Dmel_CG9553, CG9553, Chi, Chic, D88, Dmel\CG9553, GH4, chi, l(2)27/7, profilin, sand " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010876 33834 chic http://www.ncbi.nlm.nih.gov/gene/?term=33834 "Dmel_CG9553, CG9553, Chi, Chic, D88, Dmel\CG9553, GH4, chi, l(2)27/7, profilin, sand " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010877 338350 Acad12 http://www.ncbi.nlm.nih.gov/gene/?term=338350 9330129D05Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010878 338352 Nell1 http://www.ncbi.nlm.nih.gov/gene/?term=338352 "B230343H07Rik, l7R6 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010879 338364 Trim65 http://www.ncbi.nlm.nih.gov/gene/?term=338364 4732463G12Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00010880 338372 Map3k9 http://www.ncbi.nlm.nih.gov/gene/?term=338372 "E130314H24Rik, Mlk1, Prke1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010881 3383 ICAM1 http://www.ncbi.nlm.nih.gov/gene/?term=3383 "BB2, CD54, P3.58 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010882 3383 ICAM1 http://www.ncbi.nlm.nih.gov/gene/?term=3383 "BB2, CD54, P3.58 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010883 338428 SNORD109A http://www.ncbi.nlm.nih.gov/gene/?term=338428 HBII-438A snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00010884 338429 SNORD109B http://www.ncbi.nlm.nih.gov/gene/?term=338429 HBII-438B snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00010885 338440 ANO9 http://www.ncbi.nlm.nih.gov/gene/?term=338440 "PIG5, TMEM16J, TP53I5 " mRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00010886 338448 GTF2IP2 http://www.ncbi.nlm.nih.gov/gene/?term=338448 lncRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00010887 338467 Morc3 http://www.ncbi.nlm.nih.gov/gene/?term=338467 "1110051N18Rik, AI452146, BF318192, D16Jhu32e, NXP2, Zcwcc3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00010888 3384 ICAM2 http://www.ncbi.nlm.nih.gov/gene/?term=3384 CD102 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010889 3385 ICAM3 http://www.ncbi.nlm.nih.gov/gene/?term=3385 "CD50, CDW50, ICAM-R " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010890 3385 ICAM3 http://www.ncbi.nlm.nih.gov/gene/?term=3385 "CD50, CDW50, ICAM-R " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010891 33861 Kr-h1 http://www.ncbi.nlm.nih.gov/gene/?term=33861 "Dmel_CG45074, 44/11, CG18783, CG45074, CG9167, Dmel\CG45074, Dmel_CG18783, Kr h, Kr-H1, Kr-h, P381, Pow, l(2)05208, l(2)10642 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010892 33863 stai http://www.ncbi.nlm.nih.gov/gene/?term=33863 "Dmel_CG31641, BEST:LD33989, CG31641, CG5981, D-stat, Dmel\CG31641, LD33989, SCG10-like, rdt, rdtp " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010893 33863 stai http://www.ncbi.nlm.nih.gov/gene/?term=33863 "Dmel_CG31641, BEST:LD33989, CG31641, CG5981, D-stat, Dmel\CG31641, LD33989, SCG10-like, rdt, rdtp " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010894 338657 CCDC84 http://www.ncbi.nlm.nih.gov/gene/?term=338657 DLNB14 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010895 338657 CCDC84 http://www.ncbi.nlm.nih.gov/gene/?term=338657 DLNB14 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010896 338692 ANKRD13D http://www.ncbi.nlm.nih.gov/gene/?term=338692 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010897 3386 ICAM4 http://www.ncbi.nlm.nih.gov/gene/?term=3386 "CD242, LW " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010898 338773 TMEM119 http://www.ncbi.nlm.nih.gov/gene/?term=338773 OBIF mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010899 338773 TMEM119 http://www.ncbi.nlm.nih.gov/gene/?term=338773 OBIF mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010900 33881 PDZ-GEF http://www.ncbi.nlm.nih.gov/gene/?term=33881 "Dmel_CG9491, CG9491, D-PDZGEF, DGEF, Dmel\CG9491, Dzy, EC2-8, GEF, Gef26, PDF-GEF Dizzy, dPDZ-GEF, dizzy, dzy, l(2)k13720 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010901 33904 CG9536 http://www.ncbi.nlm.nih.gov/gene/?term=33904 Dmel_ Dmel\CG9536 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010902 33916 eya http://www.ncbi.nlm.nih.gov/gene/?term=33916 "Dmel_CG9554, 24582246, BcDNA:LD16029, CG9554, CLI, CLIFT, Dmel\CG9554, EY2-1, EYA, Eya, cli, cli/eya, dEYA, del1, eay, ey-2 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010903 339175 METTL2A http://www.ncbi.nlm.nih.gov/gene/?term=339175 METTL2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010904 339201 ASB16-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=339201 C17orf65 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010905 339201 ASB16-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=339201 C17orf65 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010906 339229 OXLD1 http://www.ncbi.nlm.nih.gov/gene/?term=339229 C17orf90 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010907 339230 CCDC137 http://www.ncbi.nlm.nih.gov/gene/?term=339230 RaRF mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010908 339231 ARL16 http://www.ncbi.nlm.nih.gov/gene/?term=339231 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010909 339263 C17orf51 http://www.ncbi.nlm.nih.gov/gene/?term=339263 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010910 339287 MSL1 http://www.ncbi.nlm.nih.gov/gene/?term=339287 "MSL-1, hMSL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010911 339324 ZNF260 http://www.ncbi.nlm.nih.gov/gene/?term=339324 "OZRF1, PEX1, ZFP260 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010912 339324 ZNF260 http://www.ncbi.nlm.nih.gov/gene/?term=339324 "OZRF1, PEX1, ZFP260 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010913 33934 cup http://www.ncbi.nlm.nih.gov/gene/?term=33934 "Dmel_CG11181, CG11181, CUP, Cup, DmCup, Dmel\CG11181, fs(1) fs(2)cup, i239 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010914 339366 ADAMTSL5 http://www.ncbi.nlm.nih.gov/gene/?term=339366 THSD6 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010915 339448 C1orf174 http://www.ncbi.nlm.nih.gov/gene/?term=339448 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010916 339448 C1orf174 http://www.ncbi.nlm.nih.gov/gene/?term=339448 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010917 339448 C1orf174 http://www.ncbi.nlm.nih.gov/gene/?term=339448 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010918 339448 C1orf174 http://www.ncbi.nlm.nih.gov/gene/?term=339448 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010919 339451 KLHL17 http://www.ncbi.nlm.nih.gov/gene/?term=339451 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010920 339451 KLHL17 http://www.ncbi.nlm.nih.gov/gene/?term=339451 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010921 339456 TMEM52 http://www.ncbi.nlm.nih.gov/gene/?term=339456 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010922 339483 MTMR9LP http://www.ncbi.nlm.nih.gov/gene/?term=339483 MTMR9L lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010923 339487 ZBTB8OS http://www.ncbi.nlm.nih.gov/gene/?term=339487 "ARCH, ARCH2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010924 3394 IRF8 http://www.ncbi.nlm.nih.gov/gene/?term=3394 "H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010925 3394 IRF8 http://www.ncbi.nlm.nih.gov/gene/?term=3394 "H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010926 33966 nop5 http://www.ncbi.nlm.nih.gov/gene/?term=33966 "Dmel_CG10206, 2/30, CG10206, DNOP5, Dmel\CG10206, D FBgn0026196, NOP5, Nop5 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010927 3396 ICT1 http://www.ncbi.nlm.nih.gov/gene/?term=3396 "DS-1, DS1, MRP-L58 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010928 33974 SA http://www.ncbi.nlm.nih.gov/gene/?term=33974 "Dmel_CG3423, CG3423, DSA, DSA1, DmSA, Dmel\CG3423, ESTS:92H2T, SCC3, Scc3 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010929 33974 SA http://www.ncbi.nlm.nih.gov/gene/?term=33974 "Dmel_CG3423, CG3423, DSA, DSA1, DmSA, Dmel\CG3423, ESTS:92H2T, SCC3, Scc3 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010930 3397 ID1 http://www.ncbi.nlm.nih.gov/gene/?term=3397 "ID, bHLHb24 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010931 3397 ID1 http://www.ncbi.nlm.nih.gov/gene/?term=3397 "ID, bHLHb24 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010932 33981 smt3 http://www.ncbi.nlm.nih.gov/gene/?term=33981 "Dmel_CG4494, CG4494, Dm0342, DmSUMO-1, DmSmt3, Dmel\CG4494, Dm SMT3, SUMO, Smt3, Sumo, anon-EST:Posey240, dSmt3, dsmt3, l(2)04493, l(2)SH0182, l(2)SH2 0182, sumo " mRNA Drosophila melanogaster 24058701 Cytosol S2 cell qRT-PCR "As predicted from its sequence and the known cytosolic/nuclear functions of the sumo protein, sumo mRNA was highly enriched in the cytosolic fraction, along with the mRNA encoding actin (Figure 1D). " RLID00010933 33982 snRNP-U1-70K http://www.ncbi.nlm.nih.gov/gene/?term=33982 "Dmel_CG8749, 70K, CG8749, Dm70K, Dmel\CG8749, U1, U1 70K, U1 70K snRNP, U1 70k, U1 snRNP, U1-70K, U1-70k, U170K, U1snRNP-70K, dU1-70K, l(2)02107, snRNP, snRNP27D, snRNP70K " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010934 339834 CCDC36 http://www.ncbi.nlm.nih.gov/gene/?term=339834 CT74 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010935 339834 CCDC36 http://www.ncbi.nlm.nih.gov/gene/?term=339834 CT74 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010936 3398 ID2 http://www.ncbi.nlm.nih.gov/gene/?term=3398 "GIG8, ID2A, ID2H, bHLHb26 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010937 3398 ID2 http://www.ncbi.nlm.nih.gov/gene/?term=3398 "GIG8A, ID2H, bHLHb26, ID2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010938 3398 ID2 http://www.ncbi.nlm.nih.gov/gene/?term=3398 "GIG8A, ID2H, bHLHb26, ID2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010939 339983 NAT8L http://www.ncbi.nlm.nih.gov/gene/?term=339983 "CML3, NACED, NAT8-LIKE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010940 3399 ID3 http://www.ncbi.nlm.nih.gov/gene/?term=3399 "HEIR-1, bHLHb25 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010941 3399 ID3 http://www.ncbi.nlm.nih.gov/gene/?term=3399 "HEIR-1, bHLHb25 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010942 340061 TMEM173 http://www.ncbi.nlm.nih.gov/gene/?term=340061 "ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010943 340075 ARSI http://www.ncbi.nlm.nih.gov/gene/?term=340075 SPG66 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010944 34009 wg http://www.ncbi.nlm.nih.gov/gene/?term=34009 "Dmel_CG4889, Br, CG4889, DWint-1, DWnt-1, Dint-1, Dm Wg, Dm-1, Dmel\CG4889, Gla, I, Sp, WG, WNT, Wg, Wnt, Wnt-1, Wnt/Wg, Wnt1, dWnt, fg, int-1, l(2)02657, l(2)rO727, l(2)wg, spdl, wnt, wnt1, wg " mRNA Drosophila melanogaster 18045835 Apical Embryo Fluorescence in situ hybridization "Wilkie and Davis (Wilkie and Davis, 2001) have shown that wg mRNA localizes apically in a Dynein-dependent fashion when injected into syncitial stage Drosophila embryos. Consistent with their findings, we found that reporter RNA containing the wg 3UTR is localized to apical cytoplasm within 8 minutes after injection, in 97% of embryos (construct FL, Fig. 1B, Table 2). " RLID00010945 34009 wg http://www.ncbi.nlm.nih.gov/gene/?term=34009 "Dmel_CG4889, Br, CG4889, DWint-1, DWnt-1, Dint-1, Dm Wg, Dm-1, Dmel\CG4889, Gla, I, Sp, WG, WNT, Wg, Wnt, Wnt-1, Wnt/Wg, Wnt1, dWnt, fg, int-1, l(2)02657, l(2)rO727, l(2)wg, spdl, wnt, wnt1, wg " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00010946 340206 TREML3P http://www.ncbi.nlm.nih.gov/gene/?term=340206 "TLT3, TREML3 " lncRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010947 340252 ZNF680 http://www.ncbi.nlm.nih.gov/gene/?term=340252 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010948 34032 RapGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=34032 "Dmel_CG44086, CG13789, CG13790, CG13791, CG33529, CG34374, CG44086, CG6682, Dmel\CG44086, Dmel_CG13790, Dmel_CG13791, Dmel_CG33529, Dmel_CG34374, Q9VM02_DROME, RapGap1, Rapgap1, rapgap1 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010949 34032 RapGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=34032 "Dmel_CG44086, CG13789, CG13790, CG13791, CG33529, CG34374, CG44086, CG6682, Dmel\CG44086, Dmel_CG13790, Dmel_CG13791, Dmel_CG33529, Dmel_CG34374, Q9VM02_DROME, RapGap1, Rapgap1, rapgap1 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010950 34032 RapGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=34032 "Dmel_CG44086, CG13789, CG13790, CG13791, CG33529, CG34374, CG44086, CG6682, Dmel\CG44086, Dmel_CG13790, Dmel_CG13791, Dmel_CG33529, Dmel_CG34374, Q9VM02_DROME, RapGap1, Rapgap1, rapgap1 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010951 340348 TSPAN33 http://www.ncbi.nlm.nih.gov/gene/?term=340348 "PEN, PEN., TSPAN-33 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010952 34037 CG6739 http://www.ncbi.nlm.nih.gov/gene/?term=34037 Dmel_ Dmel\CG6739 mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010953 34037 CG6739 http://www.ncbi.nlm.nih.gov/gene/?term=34037 Dmel_ Dmel\CG6739 mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010954 34044 Tep2 http://www.ncbi.nlm.nih.gov/gene/?term=34044 "Dmel_CG7052, 145970_at, 145971_at, CG18589, CG7052, Dmel\CG7052, T13, TEP II, TEP2, TEP2mel, Tep 2, Tep II, TepII, dTEPII, tepII " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010955 340481 ZDHHC21 http://www.ncbi.nlm.nih.gov/gene/?term=340481 "9130404H11Rik, DHHC-21, DHHC21, DNZ1, HSPC097 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010956 340485 ACER2 http://www.ncbi.nlm.nih.gov/gene/?term=340485 "ALKCDase2, ASAH3L " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010957 340485 ACER2 http://www.ncbi.nlm.nih.gov/gene/?term=340485 "ALKCDase2, ASAH3L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010958 340542 BEX5 http://www.ncbi.nlm.nih.gov/gene/?term=340542 NGFRAP1L1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010959 340547 VSIG1 http://www.ncbi.nlm.nih.gov/gene/?term=340547 "1700062D20Rik, GPA34, dJ889N15.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010960 340547 VSIG1 http://www.ncbi.nlm.nih.gov/gene/?term=340547 "1700062D20Rik, GPA34, dJ889N15.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010961 340554 ZC3H12B http://www.ncbi.nlm.nih.gov/gene/?term=340554 "CXorf32, MCPIP2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010962 340554 ZC3H12B http://www.ncbi.nlm.nih.gov/gene/?term=340554 "CXorf32, MCPIP2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010963 340554 ZC3H12B http://www.ncbi.nlm.nih.gov/gene/?term=340554 "CXorf32, MCPIP2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010964 340591 CA5BP1 http://www.ncbi.nlm.nih.gov/gene/?term=340591 "CA5BL, CA5BP, PRO2325 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010965 34087 pes http://www.ncbi.nlm.nih.gov/gene/?term=34087 "Dmel_CG7228, CG7228, Dmel\CG7228, Pes " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010966 340895 MALRD1 http://www.ncbi.nlm.nih.gov/gene/?term=340895 "C10orf112, DIET1, bA265G8.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010967 341032 C11orf53 http://www.ncbi.nlm.nih.gov/gene/?term=341032 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010968 341116 MS4A10 http://www.ncbi.nlm.nih.gov/gene/?term=341116 "CD20L7, MS4A9 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010969 341116 MS4A10 http://www.ncbi.nlm.nih.gov/gene/?term=341116 "CD20L7, MS4A9 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00010970 34134 wol http://www.ncbi.nlm.nih.gov/gene/?term=34134 "Dmel_CG7870, ALG5, CG7870, Dmel\CG7870, Wol, alg5, dAlg5 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010971 34136 CG7840 http://www.ncbi.nlm.nih.gov/gene/?term=34136 "Dmel_ Dmel\CG7840, cg7840 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010972 34137 Ostgamma http://www.ncbi.nlm.nih.gov/gene/?term=34137 "Dmel_CG7830, CG7830, Dmel\CG7830, MagT1, OST, dMagT1 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010973 34137 Ostgamma http://www.ncbi.nlm.nih.gov/gene/?term=34137 "Dmel_CG7830, CG7830, Dmel\CG7830, MagT1, OST, dMagT1 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010974 3416 IDE http://www.ncbi.nlm.nih.gov/gene/?term=3416 INSULYSIN mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010975 3416 IDE http://www.ncbi.nlm.nih.gov/gene/?term=3416 INSULYSIN mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010976 3416 IDE http://www.ncbi.nlm.nih.gov/gene/?term=3416 INSULYSIN mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00010977 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 10024878 Nucleus Oocyte In situ hybridization "The requirement for microtubules is most clearly seen by confocal microscopy of oocytes nuclear antigen scripts are detected in the oocytes (arrowheads) but are not lolamin. In the absence of microtubules,grkm RNA aggregates into one or a few larg clumps on the surfaceof the oocyte nucleus (Figure 2A). " RLID00010978 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 10024878 Anterior Oocyte In situ hybridization "During nuclear migration, about 50% of the grk mRNA is closely associated with the ER (Figures 3D-3F). Toward the end of midoogenesis, the ER and grk mRNA are both concentrated along the anterior cortex and again are closely associated with each other (data not shown). During late oogenesis, all of the grk mRNA is associated with the ER, although the ER remains distributed over the entire anterior cortex (Figures 3E-3F). " RLID00010979 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 10024878 Endoplasmic reticulum Oocyte In situ hybridization "During nuclear migration, about 50% of the grk mRNA is closely associated with the ER (Figures 3D-3F). Toward the end of midoogenesis, the ER and grk mRNA are both concentrated along the anterior cortex and again are closely associated with each other (data not shown). During late oogenesis, all of the grk mRNA is associated with the ER, although the ER remains distributed over the entire anterior cortex (Figures 3E-3F). " RLID00010980 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 11131516 Posterior Embryo In situ hybridization "For its assembly, localization of gurken mRNA and its translation at the posterior pole of early oogenic stages is essential for establishing the posterior pole of the oocyte. Subsequently, oskar mRNA becomes localized to the posterior pole where its translation leads to the assembly of a functional germ plasm " RLID00010981 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 15385627 Golgi apparatus Oocyte|Neuron cell In situ hybridization "And we show, by using three Drosophila mutants in which gurken mRNA is mislocalized, that what controls the choice of the tER-Golgi units involved in Gurken transport, among the thousand present, is the localization of gurken mRNA. This pretranslational mechanism is coupled to posttranslational sorting events involving Cornichon and the transmembrane domain of Gurken that prevent its diffusion in the ER away from the D/A corner and ensure its efficient sorting to the tER-Golgi units at that same corner. " RLID00010982 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 15385627 Endoplasmic reticulum Oocyte|Neuron cell In situ hybridization "Using Drosophila mutants, we show that it is the localization of gurken mRNA coupled to efficient sorting of Gurken out of the ER that determines which of the numerous equivalent tER-Golgi units are used for the protein transport and processing. The choice of tER-Golgi units by mRNA localization makes them independent of each other and represents a nonconventional way, by which the oocyte implements polarized deposition of transmembrane/secreted proteins. " RLID00010983 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 16319114 Dorsal Oocyte In situ hybridization "Oskar (osk) mRNA is transported to the posterior pole and gurken (grk) mRNA is localized to an antero-dorsal cap near the oocyte nucleus (reviewed by Riechmann and Ephrussi, 2001). The localization of these axes determining transcripts occurs in several steps and is dependent on MTs, cytoplasmic Dynein and Kinesin I. " RLID00010984 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 19217894 Cell cortex Oocyte In situ hybridization "The grk mRNA adopts a position at the junction between anterior and lateral cortex of the oocyte, adjacent to the nucleus and at the site destined to become the dorsal surface of the embryo. " RLID00010985 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 24531791 Anterior Oocyte In situ hybridization Figure 6: Anterior-central grk mRNA localization in saturn is due to joint inactivation of klc and piRNA pathway. RLID00010986 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 24531791 Cell cortex Oocyte In situ hybridization "Grk mRNA is normally tightly associated with the oocyte cortex but, in stage 9 klcsat oocytes, approximately one-half of the grk mRNA is somewhat internally localized (Figure 6C), a phenotype that is evident from as early as stage 2 (Figure 6I). A similar phenotype is seen in klc8ex94 germline clones. " RLID00010987 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 24531791 Dorsal Oocyte In situ hybridization "Like other piRNA pathway mutations, armi oocytes show phenotypes associated with the response to DNA damage caused by excessive transposon expression, including failure to restrict anterior grk mRNA localization to a dorsal corner (Figure 5A) due to a misorganized MT cytoskeleton, silencing of Grk translation, and disruption of the karyosome. " RLID00010988 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 24531791 Dorsal Oocyte In situ hybridization "In klc oocytes, a population of grk mRNA still localizes to the dorsal cortex, away from the centrosomes, which now lie ventral to the nucleus (Figure 7E). " RLID00010989 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 24531791 Dorsal Oocyte In situ hybridization "We also show that initiation of the dorsoanterior localization of grk mRNA precedes centrosome localization, suggesting that microtubule self-organization contributes to breaking axial symmetry to generate a unique dorsoventral axis. " RLID00010990 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 24531791 Cytoskeleton Oocyte In situ hybridization "We also show that initiation of the dorsoanterior localization of grk mRNA precedes centrosome localization, suggesting that microtubule self-organization contributes to breaking axial symmetry to generate a unique dorsoventral axis.We also show that initiation of the dorsoanterior localization of grk mRNA precedes centrosome localization, suggesting that microtubule self-organization contributes to breaking axial symmetry to generate a unique dorsoventral axis. " RLID00010991 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 24531791 Posterior Oocyte In situ hybridization "A particularly significant target of dynein-mediated transport is gurken (grk) whose transcript localization is key to establishing the prospective body axes of the future embryo. grk mRNA localizes posteriorly in early oocytes and is translated during stage 5 into a transforming growth factor-a like protein that signals to overlying, somatic follicle cells to specify their posterior character. During this stage, the minus-ends of MTs are orientated predominantly toward the oocyte posterior. " RLID00010992 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 24718986 Nucleus Oocyte In situ hybridization "Fig. 6. osk mRNA localization is affected in Chcnull germline clones. ChcGF23 germline clones marked by the absence of nuclear GFP signal (green). (A) grk mRNA (red) is enriched at the posterior in stage 6 egg chambers in wild-type and mutant clones. At stage 7-8, grk mRNA is found at the anterior dorsal side of the nucleus. (B) osk mRNA (red) is enriched in the oocyte and at the posterior during early oogenesis (up to stage 6). " RLID00010993 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 26214278 Cytoplasm Oocyte - This is achieved through the cytoplasmic localization of grk mRNA and regulation of its translation. RLID00010994 34171 grk http://www.ncbi.nlm.nih.gov/gene/?term=34171 "Dmel_CG17610, CG17610, CT32746, Dmel\CG17610, GRK, Grk, s-Grk " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010995 3417 IDH1 http://www.ncbi.nlm.nih.gov/gene/?term=3417 "HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010996 3418 IDH2 http://www.ncbi.nlm.nih.gov/gene/?term=3418 "D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00010997 3418 IDH2 http://www.ncbi.nlm.nih.gov/gene/?term=3418 "D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00010998 34191 CG17834 http://www.ncbi.nlm.nih.gov/gene/?term=34191 "Dmel_ BcDNA:LP07538, Dmel\CG17834, anon-290a, anon-29Da " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00010999 3419 IDH3A http://www.ncbi.nlm.nih.gov/gene/?term=3419 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011000 3419 IDH3A http://www.ncbi.nlm.nih.gov/gene/?term=3419 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011001 341 APOC1 http://www.ncbi.nlm.nih.gov/gene/?term=341 "Apo-CI, ApoC-I " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011002 3420 IDH3B http://www.ncbi.nlm.nih.gov/gene/?term=3420 "H-IDHB, RP46 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011003 3421 IDH3G http://www.ncbi.nlm.nih.gov/gene/?term=3421 H-IDHG mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011004 3421 IDH3G http://www.ncbi.nlm.nih.gov/gene/?term=3421 H-IDHG mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011005 3422 IDI1 http://www.ncbi.nlm.nih.gov/gene/?term=3422 "IPP1, IPPI1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011006 3422 IDI1 http://www.ncbi.nlm.nih.gov/gene/?term=3422 "IPP1, IPPI1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011007 34237 CG32982 http://www.ncbi.nlm.nih.gov/gene/?term=34237 "Dmel_ CG18566, CG9584, CG9585, Dmel\CG32982 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011008 3423 IDS http://www.ncbi.nlm.nih.gov/gene/?term=3423 "MPS2, SIDS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011009 3423 IDS http://www.ncbi.nlm.nih.gov/gene/?term=3423 "MPS2, SIDS " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011010 3423 IDS http://www.ncbi.nlm.nih.gov/gene/?term=3423 "MPS2, SIDS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011011 34245 borr http://www.ncbi.nlm.nih.gov/gene/?term=34245 "Dmel_CG4454, BORR, Bor, Borr, CG4454, Dmel\CG4454, dBor " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011012 34245 borr http://www.ncbi.nlm.nih.gov/gene/?term=34245 "Dmel_CG4454, BORR, Bor, Borr, CG4454, Dmel\CG4454, dBor " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011013 34263 numb http://www.ncbi.nlm.nih.gov/gene/?term=34263 "Dmel_CG3779, CG3779, Dmel\CG3779, N7-1, Nb, Numb, d-numb, dNumb, l(2)03235, l(2)3235, l(2)s2201, nbs " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011014 3426 CFI http://www.ncbi.nlm.nih.gov/gene/?term=3426 "AHUS3, ARMD13, C3BINA, C3b-INA, FI, IF, KAF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011015 34286 pelo http://www.ncbi.nlm.nih.gov/gene/?term=34286 "Dmel_CG3959, CG3959, Dmel\CG3959, ms(2)01559 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011016 34286 pelo http://www.ncbi.nlm.nih.gov/gene/?term=34286 "Dmel_CG3959, CG3959, Dmel\CG3959, ms(2)01559 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011017 342926 ZNF677 http://www.ncbi.nlm.nih.gov/gene/?term=342926 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011018 342926 ZNF677 http://www.ncbi.nlm.nih.gov/gene/?term=342926 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011019 34292 zf30C http://www.ncbi.nlm.nih.gov/gene/?term=34292 "Dmel_CG3998, C282, CG3998, Dmel\CG3998, Zf30c, Zn30C, anon-EST:Liang-1.52, clone 1.52, l(2)k02506, zf30c " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011020 342945 ZSCAN22 http://www.ncbi.nlm.nih.gov/gene/?term=342945 "HKR2, ZNF50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011021 342945 ZSCAN22 http://www.ncbi.nlm.nih.gov/gene/?term=342945 "HKR2, ZNF50 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011022 342945 ZSCAN22 http://www.ncbi.nlm.nih.gov/gene/?term=342945 "HKR2, ZNF50 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011023 3429 IFI27 http://www.ncbi.nlm.nih.gov/gene/?term=3429 "FAM14D, ISG12, ISG12A, P27 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011024 3429 IFI27 http://www.ncbi.nlm.nih.gov/gene/?term=3429 "FAM14D, ISG12, ISG12A, P27 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011025 34309 RpS2 http://www.ncbi.nlm.nih.gov/gene/?term=34309 "Dmel_CG5920, CG5920, Dm01335, Dmel\CG5920, Rp S2, S2, anon-EST:Posey202, dS2, l(2)03848, l(2)k04603, sop " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011026 3430 IFI35 http://www.ncbi.nlm.nih.gov/gene/?term=3430 IFP35 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011027 3430 IFI35 http://www.ncbi.nlm.nih.gov/gene/?term=3430 IFP35 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011028 3431 SP110 http://www.ncbi.nlm.nih.gov/gene/?term=3431 "IFI41, IFI75, IPR1, VODI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011029 34321 CG4619 http://www.ncbi.nlm.nih.gov/gene/?term=34321 "Dmel_ CG31879, Dmel\CG4619 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011030 34330 bib http://www.ncbi.nlm.nih.gov/gene/?term=34330 "Dmel_CG4722, BIB_DROME, Bib, CG4722, Dmel\CG4722, EP(2)2278, l(2)neo66, l(2)neo91, m-bib " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011031 34330 bib http://www.ncbi.nlm.nih.gov/gene/?term=34330 "Dmel_CG4722, BIB_DROME, Bib, CG4722, Dmel\CG4722, EP(2)2278, l(2)neo66, l(2)neo91, m-bib " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011032 34338 Pen http://www.ncbi.nlm.nih.gov/gene/?term=34338 "Dmel_CG4799, 2.1, CG4799, DPend, Dalpha2, Dimp-alpha2, Dmel\CG4799, IMPalpha2, Imp-alpha2, Kap alpha2, Kap-alpha2, Kpna2, OHO31, Oho31, Rch1, alpha2, alpha2A-Kap, alphaKap2, anon-WO0140519.258, bs29g06.y1, imp alpha2, imp-alpha2, impalpha2, importin alpha2/pendulin, l(2)144/1, l(2)k06324, l(2)k14401, oho-31, oho31, pen, pen-2 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011033 343450 KCNT2 http://www.ncbi.nlm.nih.gov/gene/?term=343450 "KCa4.2, SLICK, SLO2.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011034 3434 IFIT1 http://www.ncbi.nlm.nih.gov/gene/?term=3434 "C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011035 3434 IFIT1 http://www.ncbi.nlm.nih.gov/gene/?term=3434 "C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011036 3434 IFIT1 http://www.ncbi.nlm.nih.gov/gene/?term=3434 "C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011037 34377 Utx http://www.ncbi.nlm.nih.gov/gene/?term=34377 "Dmel_CG5640, CG5640, Dmel\CG5640, UTX, anon-31BCa, dUTX, dUtx, utx " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00011038 343990 KIAA1211L http://www.ncbi.nlm.nih.gov/gene/?term=343990 C2orf55 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011039 343 AQP8 http://www.ncbi.nlm.nih.gov/gene/?term=343 AQP-8 mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00011040 34416 Cnot4 http://www.ncbi.nlm.nih.gov/gene/?term=34416 "Dmel_CG31716, CG31716, CG5244, CG5251, Cont4, Dmel\CG31716, NOT4, Not4, Q8IPB9_DROME, cg5251, not4 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00011041 34419 Ip259 http://www.ncbi.nlm.nih.gov/gene/?term=34419 "Dmel_CG5277, CG5277, Dmel\CG5277, IP259 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011042 34419 Ip259 http://www.ncbi.nlm.nih.gov/gene/?term=34419 "Dmel_CG5277, CG5277, Dmel\CG5277, IP259 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011043 34449 Lrr47 http://www.ncbi.nlm.nih.gov/gene/?term=34449 "Dmel_CG6098, CG6098, CT19173, Dmel\CG6098, LRR47, Lrr-47 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011044 34450 Lip4 http://www.ncbi.nlm.nih.gov/gene/?term=34450 "Dmel_CG6113, CG6113, Dmel\CG6113, dLip4, dlip4 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011045 34450 Lip4 http://www.ncbi.nlm.nih.gov/gene/?term=34450 "Dmel_CG6113, CG6113, Dmel\CG6113, dLip4, dlip4 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011046 34450 Lip4 http://www.ncbi.nlm.nih.gov/gene/?term=34450 "Dmel_CG6113, CG6113, Dmel\CG6113, dLip4, dlip4 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011047 34465 CG17104 http://www.ncbi.nlm.nih.gov/gene/?term=34465 "Dmel_ BEST:LD16579, Dmel\CG17104 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011048 34465 CG17104 http://www.ncbi.nlm.nih.gov/gene/?term=34465 "Dmel_ BEST:LD16579, Dmel\CG17104 " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011049 34465 CG17104 http://www.ncbi.nlm.nih.gov/gene/?term=34465 "Dmel_ BEST:LD16579, Dmel\CG17104 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011050 34485 CG17124 http://www.ncbi.nlm.nih.gov/gene/?term=34485 "Dmel_ Dmel\CG17124, anon-WO0118547.153 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011051 34485 CG17124 http://www.ncbi.nlm.nih.gov/gene/?term=34485 "Dmel_ Dmel\CG17124, anon-WO0118547.153 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011052 34486 CG6495 http://www.ncbi.nlm.nih.gov/gene/?term=34486 "Dmel_ BcDNA:GH10711, Dmel\CG6495, GH10711 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011053 34486 CG6495 http://www.ncbi.nlm.nih.gov/gene/?term=34486 "Dmel_ BcDNA:GH10711, Dmel\CG6495, GH10711 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011054 34503 Dnz1 http://www.ncbi.nlm.nih.gov/gene/?term=34503 "Dmel_CG6627, CG6627, DNZ1, Dmel\CG6627 " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011055 34514 CG33129 http://www.ncbi.nlm.nih.gov/gene/?term=34514 "Dmel_ CG6087, CG6089, Dmel\CG33129 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011056 34514 CG33129 http://www.ncbi.nlm.nih.gov/gene/?term=34514 "Dmel_ CG6087, CG6089, Dmel\CG33129 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011057 345193 LRIT3 http://www.ncbi.nlm.nih.gov/gene/?term=345193 "CSNB1F, FIGLER4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011058 345193 LRIT3 http://www.ncbi.nlm.nih.gov/gene/?term=345193 "CSNB1F, FIGLER4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011059 34521 piwi http://www.ncbi.nlm.nih.gov/gene/?term=34521 "Dmel_CG6122, CG6122, Dmel\CG6122, PIWI, Piwi " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011060 34521 piwi http://www.ncbi.nlm.nih.gov/gene/?term=34521 "Dmel_CG6122, CG6122, Dmel\CG6122, PIWI, Piwi " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011061 345275 HSD17B13 http://www.ncbi.nlm.nih.gov/gene/?term=345275 "HMFN0376, NIIL497, SCDR9, SDR16C3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011062 345275 HSD17B13 http://www.ncbi.nlm.nih.gov/gene/?term=345275 "HMFN0376, NIIL497, SCDR9, SDR16C3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011063 34549 Nup160 http://www.ncbi.nlm.nih.gov/gene/?term=34549 "Dmel_CG4738, CG4738, Dmel\CG4738, Nup[mel], l(2)SH2 2055, l(2)SH2055, nup160, Nup160 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011064 34549 Nup160 http://www.ncbi.nlm.nih.gov/gene/?term=34549 "Dmel_CG4738, CG4738, Dmel\CG4738, Nup[mel], l(2)SH2 2055, l(2)SH2055, nup160, Nup160 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011065 3454 IFNAR1 http://www.ncbi.nlm.nih.gov/gene/?term=3454 "AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011066 3454 IFNAR1 http://www.ncbi.nlm.nih.gov/gene/?term=3454 "AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011067 3454 IFNAR1 http://www.ncbi.nlm.nih.gov/gene/?term=3454 "AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011068 3454 IFNAR1 http://www.ncbi.nlm.nih.gov/gene/?term=3454 "AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011069 3455 IFNAR2 http://www.ncbi.nlm.nih.gov/gene/?term=3455 "IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011070 34565 mre11 http://www.ncbi.nlm.nih.gov/gene/?term=34565 "Dmel_CG16928, 16928, CG16928, Dmel\CG16928, MRE11, Mre11 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011071 345757 FAM174A http://www.ncbi.nlm.nih.gov/gene/?term=345757 "HGS_RE408, TMEM157, UNQ1912 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011072 345778 MTX3 http://www.ncbi.nlm.nih.gov/gene/?term=345778 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011073 345778 MTX3 http://www.ncbi.nlm.nih.gov/gene/?term=345778 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011074 345778 MTX3 http://www.ncbi.nlm.nih.gov/gene/?term=345778 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011075 34577 CG31705 http://www.ncbi.nlm.nih.gov/gene/?term=34577 "Dmel_ BcDNA:GH07269, CG6528, Dmel\CG31705 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011076 34577 CG31705 http://www.ncbi.nlm.nih.gov/gene/?term=34577 "Dmel_ BcDNA:GH07269, CG6528, Dmel\CG31705 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011077 34592 crol http://www.ncbi.nlm.nih.gov/gene/?term=34592 "Dmel_CG14938, CG14938, Crol, Dmel\CG14938, ORE-15, anon-EST:Liang-1.74, anon-EST:Liang-2.48, clone 1.74, clone 2.48 alpha, crol beta, crol gamma, l(2)04418, l(2)s2346, crol " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011078 3459 IFNGR1 http://www.ncbi.nlm.nih.gov/gene/?term=3459 "CD119, IFNGR, IMD27A, IMD27B " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011079 3459 IFNGR1 http://www.ncbi.nlm.nih.gov/gene/?term=3459 "CD119, IFNGR, IMD27A, IMD27B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011080 3460 IFNGR2 http://www.ncbi.nlm.nih.gov/gene/?term=3460 "AF-1, IFGR2, IFNGT1, IMD28 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011081 3460 IFNGR2 http://www.ncbi.nlm.nih.gov/gene/?term=3460 "AF-1, IFGR2, IFNGT1, IMD28 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011082 3460 IFNGR2 http://www.ncbi.nlm.nih.gov/gene/?term=3460 "AF-1, IFGR2, IFNGT1, IMD28 " mRNA Homo sapiens 24019514 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmids containing either ALPP, t-ftz, or the AF1, AF2 fusion constructs and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (Ctrl), puromycin (Puro), or HHT for 30 min and then extracted with either digitonin alone, or for puromycin-treated cells, with 20 mM EDTA. The cells were then fixed, stained for mRNA using specific FISH probes (ALPP probe for AF1, ftz probe for AF2), and imaged. FIGURE 2B: quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 2. " RLID00011083 3460 IFNGR2 http://www.ncbi.nlm.nih.gov/gene/?term=3460 "AF-1, IFGR2, IFNGT1, IMD28 " mRNA Homo sapiens 24019514 Nucleus COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmids containing either ALPP, t-ftz, or the AF1, AF2 fusion constructs and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (Ctrl), puromycin (Puro), or HHT for 30 min and then extracted with either digitonin alone, or for puromycin-treated cells, with 20 mM EDTA. The cells were then fixed, stained for mRNA using specific FISH probes (ALPP probe for AF1, ftz probe for AF2), and imaged. FIGURE 2B: quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 2. " RLID00011084 3460 IFNGR2 http://www.ncbi.nlm.nih.gov/gene/?term=3460 "AF-1, IFGR2, IFNGT1, IMD28 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011085 34629 prd http://www.ncbi.nlm.nih.gov/gene/?term=34629 "Dmel_CG6716, CG6716, Dmel\CG6716, PRD, Prd, pr " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011086 346389 MACC1 http://www.ncbi.nlm.nih.gov/gene/?term=346389 "7A5, SH3BP4L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011087 346389 MACC1 http://www.ncbi.nlm.nih.gov/gene/?term=346389 "7A5, SH3BP4L " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011088 346389 MACC1 http://www.ncbi.nlm.nih.gov/gene/?term=346389 "7A5, SH3BP4L " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011089 346389 MACC1 http://www.ncbi.nlm.nih.gov/gene/?term=346389 "7A5, SH3BP4L " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011090 34642 CG31760 http://www.ncbi.nlm.nih.gov/gene/?term=34642 "Dmel_ BcDNA:RE52162, CG17214, CG17215, Dmel\CG31760 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011091 34642 CG31760 http://www.ncbi.nlm.nih.gov/gene/?term=34642 "Dmel_ BcDNA:RE52162, CG17214, CG17215, Dmel\CG31760 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011092 34648 aret http://www.ncbi.nlm.nih.gov/gene/?term=34648 "Dmel_CG31762, ARET, Aret, BcDNA:GM15173, Bru, Bruno, CG31762, CG6319, Dm Bru, Dmel\CG31762, NEST:bs01g04, NEST:bs34h11/bruno1, arrest/Bruno, bru, bruno, ms(2)01284, aret " mRNA Drosophila melanogaster 17923096 Posterior Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011093 34648 aret http://www.ncbi.nlm.nih.gov/gene/?term=34648 "Dmel_CG31762, ARET, Aret, BcDNA:GM15173, Bru, Bruno, CG31762, CG6319, Dm Bru, Dmel\CG31762, NEST:bs01g04, NEST:bs34h11/bruno1, arrest/Bruno, bru, bruno, ms(2)01284, aret " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011094 34648 aret http://www.ncbi.nlm.nih.gov/gene/?term=34648 "Dmel_CG31762, ARET, Aret, BcDNA:GM15173, Bru, Bruno, CG31762, CG6319, Dm Bru, Dmel\CG31762, NEST:bs01g04, NEST:bs34h11/bruno1, arrest/Bruno, bru, bruno, ms(2)01284, aret " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011095 34648 aret http://www.ncbi.nlm.nih.gov/gene/?term=34648 "Dmel_CG31762, ARET, Aret, BcDNA:GM15173, Bru, Bruno, CG31762, CG6319, Dm Bru, Dmel\CG31762, NEST:bs01g04, NEST:bs34h11/bruno1, arrest/Bruno, bru, bruno, ms(2)01284, aret " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011096 34656 CG6388 http://www.ncbi.nlm.nih.gov/gene/?term=34656 Dmel_ Dmel\CG6388 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011097 34665 bun http://www.ncbi.nlm.nih.gov/gene/?term=34665 "Dmel_CG42281, 1550, Bun, BunA, CG31857, CG42281, CG5461, Dm_2L:60722, Dmel\CG42281, Dmel_CG31857, Dmel_CG5461, EP(2)0488, TSC-22, Tsc22, bnc, l(2)00255, l(2)02687, l(2)05479, l(2)06475, l(2)k02903, l(2)rI043, shs " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011098 34675 CG6153 http://www.ncbi.nlm.nih.gov/gene/?term=34675 "Dmel_ 6153, Dmel\CG6153 " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011099 346 APOC4 http://www.ncbi.nlm.nih.gov/gene/?term=346 "APO-CIV, APOC-IV " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011100 347240 KIF24 http://www.ncbi.nlm.nih.gov/gene/?term=347240 "C9orf48, bA571F15.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011101 34728 CG5867 http://www.ncbi.nlm.nih.gov/gene/?term=34728 "Dmel_ BcDNA:GH05536, CT18390, Dmel\CG5867 " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011102 34728 CG5867 http://www.ncbi.nlm.nih.gov/gene/?term=34728 "Dmel_ BcDNA:GH05536, CT18390, Dmel\CG5867 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011103 34735 Uvrag http://www.ncbi.nlm.nih.gov/gene/?term=34735 "Dmel_CG6116, CG6116, Dmel\CG6116, UVRAG, Vps38, uvrag " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011104 34735 Uvrag http://www.ncbi.nlm.nih.gov/gene/?term=34735 "Dmel_CG6116, CG6116, Dmel\CG6116, UVRAG, Vps38, uvrag " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011105 34735 Uvrag http://www.ncbi.nlm.nih.gov/gene/?term=34735 "Dmel_CG6116, CG6116, Dmel\CG6116, UVRAG, Vps38, uvrag " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011106 3475 IFRD1 http://www.ncbi.nlm.nih.gov/gene/?term=3475 "PC4, TIS7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011107 3475 IFRD1 http://www.ncbi.nlm.nih.gov/gene/?term=3475 "PC4, TIS7 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011108 34763 Hsp60D http://www.ncbi.nlm.nih.gov/gene/?term=34763 "Dmel_CG16954, CG16954, Dmel\CG16954 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011109 34767 B4 http://www.ncbi.nlm.nih.gov/gene/?term=34767 "Dmel_CG9239/Susi, BG:DS07660.4, CG9239, CG9260, Dmel\CG9239, Susi, n(2)05337 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011110 347694 ECEL1P2 http://www.ncbi.nlm.nih.gov/gene/?term=347694 ECEL2 lncRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00011111 3476 IGBP1 http://www.ncbi.nlm.nih.gov/gene/?term=3476 "ALPHA-4, IBP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011112 3476 IGBP1 http://www.ncbi.nlm.nih.gov/gene/?term=3476 "ALPHA-4, IBP1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011113 3476 IGBP1 http://www.ncbi.nlm.nih.gov/gene/?term=3476 "ALPHA-4, IBP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011114 347734 SLC35B2 http://www.ncbi.nlm.nih.gov/gene/?term=347734 "PAPST1, SLL, UGTrel4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011115 347734 SLC35B2 http://www.ncbi.nlm.nih.gov/gene/?term=347734 "PAPST1, SLL, UGTrel4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011116 347734 SLC35B2 http://www.ncbi.nlm.nih.gov/gene/?term=347734 "PAPST1, SLL, UGTrel4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011117 347735 SERINC2 http://www.ncbi.nlm.nih.gov/gene/?term=347735 "FKSG84, PRO0899, TDE2, TDE2L " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011118 347735 SERINC2 http://www.ncbi.nlm.nih.gov/gene/?term=347735 "FKSG84, PRO0899, TDE2, TDE2L " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011119 347740 2900097C17Rik http://www.ncbi.nlm.nih.gov/gene/?term=347740 "1810005K14Rik, 4930563C06Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00011120 347744 C6orf52 http://www.ncbi.nlm.nih.gov/gene/?term=347744 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011121 34778 TM9SF4 http://www.ncbi.nlm.nih.gov/gene/?term=34778 "Dmel_CG7364, BG:DS00797.1, CG16861, CG7364, Dmel\CG7364, n(2)k07245 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011122 347862 PDDC1 http://www.ncbi.nlm.nih.gov/gene/?term=347862 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011123 347862 PDDC1 http://www.ncbi.nlm.nih.gov/gene/?term=347862 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011124 347862 PDDC1 http://www.ncbi.nlm.nih.gov/gene/?term=347862 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011125 347862 PDDC1 http://www.ncbi.nlm.nih.gov/gene/?term=347862 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011126 3479 IGF1 http://www.ncbi.nlm.nih.gov/gene/?term=3479 "IGF-I, IGFI, MGF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011127 3479 IGF1 http://www.ncbi.nlm.nih.gov/gene/?term=3479 "IGF-I, IGFI, MGF " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011128 3479 IGF1 http://www.ncbi.nlm.nih.gov/gene/?term=3479 "IGF-I, IGFI, MGF " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011129 347 APOD http://www.ncbi.nlm.nih.gov/gene/?term=347 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011130 3480 IGF1R http://www.ncbi.nlm.nih.gov/gene/?term=3480 "CD221, IGFIR, IGFR, JTK13 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011131 3480 IGF1R http://www.ncbi.nlm.nih.gov/gene/?term=3480 "CD221, IGFIR, IGFR, JTK13 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011132 3480 IGF1R http://www.ncbi.nlm.nih.gov/gene/?term=3480 "CD221, IGFIR, IGFR, JTK13 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011133 3480 IGF1R http://www.ncbi.nlm.nih.gov/gene/?term=3480 "CD221, IGFIR, IGFR, JTK13 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011134 348110 ARPIN http://www.ncbi.nlm.nih.gov/gene/?term=348110 C15orf38 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011135 348180 CTU2 http://www.ncbi.nlm.nih.gov/gene/?term=348180 "C16orf84, NCS2, UPF0432 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011136 348180 CTU2 http://www.ncbi.nlm.nih.gov/gene/?term=348180 "C16orf84, NCS2, UPF0432 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011137 3481 IGF2 http://www.ncbi.nlm.nih.gov/gene/?term=3481 "C11orf43, GRDF, IGF-II, PP9974 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011138 348235 SKA2 http://www.ncbi.nlm.nih.gov/gene/?term=348235 FAM33A mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011139 3482 IGF2R http://www.ncbi.nlm.nih.gov/gene/?term=3482 "CD222, CIMPR, M6P-R, M6P/IGF2R, MPR 300, MPR1, MPRI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011140 3482 IGF2R http://www.ncbi.nlm.nih.gov/gene/?term=3482 "CD222, CI-M6PR, CIMPR, M6P-R, M6P/IGF2R, MPR 300, MPR1, MPR300, MPRI " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011141 3482 IGF2R http://www.ncbi.nlm.nih.gov/gene/?term=3482 "CD222, CI-M6PR, CIMPR, M6P-R, M6P/IGF2R, MPR 300, MPR1, MPR300, MPRI " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011142 348327 ZNF530 http://www.ncbi.nlm.nih.gov/gene/?term=348327 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011143 348327 ZNF530 http://www.ncbi.nlm.nih.gov/gene/?term=348327 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011144 3485 IGFBP2 http://www.ncbi.nlm.nih.gov/gene/?term=3485 "IBP2, IGF-BP53 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011145 3485 IGFBP2 http://www.ncbi.nlm.nih.gov/gene/?term=3485 "IBP2, IGF-BP53 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011146 3485 IGFBP2 http://www.ncbi.nlm.nih.gov/gene/?term=3485 "IBP2, IGF-BP53 " mRNA Homo sapiens 19175411 Ribosome T-cell|SeAx qRT-PCR "Using quantitative real-time RT-PCR we evaluated, whether mRNAs coding for differently located proteins are selectively enriched in one of the two analysed compartments, namely free versus membrane-associated polysomes. We selected genes coding for proteins located in the plasma membrane (GPR137B), secreted proteins (TIC2, IBP2, PAI) and cytosolic proteins (the house keeping genes GAPDH and HMBS). In fact, the distribution of the specific mRNA was as predicted ( Fig. 1): The average ratio of specific mRNA at bound ribosomes versus free ribosomes was 1 ? 4.4 for the housekeeping genes (GAPDH and HMBS) and 13.3 ? 1 for genes coding for membrane-bound or secreted proteins. Ratios for genes coding for cytosolic proteins were always below 0.6 and those for membrane or secreted genes were always above 1. The highest values were observed for PAI in MyLa (57 ? 1) and GPR137B in SeAx (34 ? 1), while the lowest ratios were detected for HMBS (1 ? 55) and GAPDH (1 ? 12) in HuT78. " RLID00011147 348654 GEN1 http://www.ncbi.nlm.nih.gov/gene/?term=348654 Gen mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011148 34881 Su(H) http://www.ncbi.nlm.nih.gov/gene/?term=34881 "Dmel_CG3497, BG:DS00929.10, C, CBF1, CG3497, CSL, D, Dmel\CG3497, E(H), FTZ-F2, RBJK_DROME, RBP-J kappa, RBP-J[[Kappa]], RBP-Jkappa, SU(H), SUH, Su(h), SuH, Su_H, anon-WO0257455.3, br7, dRBP-JK, dRBP-J[[Kappa]], dRBP-Jk, l(1)br7, l(2)35Bh, l(2)br7, l(2)k07904, oss, su(H) " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011149 34886 CG15270 http://www.ncbi.nlm.nih.gov/gene/?term=34886 "Dmel_ BG:DS04929.1, Dmel\CG15270 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011150 3488 IGFBP5 http://www.ncbi.nlm.nih.gov/gene/?term=3488 IBP5 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011151 3488 IGFBP5 http://www.ncbi.nlm.nih.gov/gene/?term=3488 IBP5 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011152 34890 ZnT35C http://www.ncbi.nlm.nih.gov/gene/?term=34890 "Dmel_CG3994, BG:DS07295.1, CG3994, Dmel\CG3994, cg3994, dZnT35C " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011153 348995 NUP43 http://www.ncbi.nlm.nih.gov/gene/?term=348995 "bA350J20.1, p42 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011154 348995 NUP43 http://www.ncbi.nlm.nih.gov/gene/?term=348995 "bA350J20.1, p42 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011155 348995 NUP43 http://www.ncbi.nlm.nih.gov/gene/?term=348995 "bA350J20.1, p42 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011156 348 APOE http://www.ncbi.nlm.nih.gov/gene/?term=348 "AD2, APO-E, LDLCQ5, LPG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011157 349075 ZNF713 http://www.ncbi.nlm.nih.gov/gene/?term=349075 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011158 349075 ZNF713 http://www.ncbi.nlm.nih.gov/gene/?term=349075 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011159 3490 IGFBP7 http://www.ncbi.nlm.nih.gov/gene/?term=3490 "AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011160 349114 LINC00265 http://www.ncbi.nlm.nih.gov/gene/?term=349114 NCRNA00265 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011161 3491 CYR61 http://www.ncbi.nlm.nih.gov/gene/?term=3491 "CCN1, GIG1, IGFBP10 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011162 3491 CYR61 http://www.ncbi.nlm.nih.gov/gene/?term=3491 "CCN1, GIG1, IGFBP10 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011163 34924 CycE http://www.ncbi.nlm.nih.gov/gene/?term=34924 "Dmel_CG3938, 3938, BG:DS07108.3, CDI7, CG3938, CYCE, Cdi7, Cyc, Cyc EI, CyclE, CyeE, D-CycE, DmCycE, DmcycE, DmcyclinE, Dmel\CG3938, br37, cdi7, cycE, cyclinE, cycline, dCycE, dm-cycE, fond, l(2)05206, l(2)35Dd, l(2)br37, l(2)k02514, l(2)k02602, l(2)k05007, l35Dd, CycE " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011164 34924 CycE http://www.ncbi.nlm.nih.gov/gene/?term=34924 "Dmel_CG3938, 3938, BG:DS07108.3, CDI7, CG3938, CYCE, Cdi7, Cyc, Cyc EI, CyclE, CyeE, D-CycE, DmCycE, DmcycE, DmcyclinE, Dmel\CG3938, br37, cdi7, cycE, cyclinE, cycline, dCycE, dm-cycE, fond, l(2)05206, l(2)35Dd, l(2)br37, l(2)k02514, l(2)k02602, l(2)k05007, l35Dd, CycE " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011165 34964 c(2)M http://www.ncbi.nlm.nih.gov/gene/?term=34964 "Dmel_CG4249, BG:DS02740.10, C(2)M, CG4249, DS02740.10, Dmel\CG4249, MEI-910, c(2)m, mei-910 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011166 34964 c(2)M http://www.ncbi.nlm.nih.gov/gene/?term=34964 "Dmel_CG4249, BG:DS02740.10, C(2)M, CG4249, DS02740.10, Dmel\CG4249, MEI-910, c(2)m, mei-910 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011167 34976 CaBP1 http://www.ncbi.nlm.nih.gov/gene/?term=34976 "Dmel_CG5809, AAL28897, BG:DS09218.4, CG5809, DmCaBP1, Dmel\CG5809 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011168 34985 CG5953 http://www.ncbi.nlm.nih.gov/gene/?term=34985 Dmel_ Dmel\CG5953 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011169 34993 grp http://www.ncbi.nlm.nih.gov/gene/?term=34993 "Dmel_CG17161, 1C, CG17161, CHK1, CHK1/Grapes, Chk1, Dchk1, DmChk1, Dmel\CG17161, Grp, Grp/DChk1, Pk36A, Pk?1, chk1, dChk1(chk), grps, l(2)k15102, lemp, grp " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011170 34993 grp http://www.ncbi.nlm.nih.gov/gene/?term=34993 "Dmel_CG17161, 1C, CG17161, CHK1, CHK1/Grapes, Chk1, Dchk1, DmChk1, Dmel\CG17161, Grp, Grp/DChk1, Pk36A, Pk?1, chk1, dChk1(chk), grps, l(2)k15102, lemp, grp " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011171 34 ACADM http://www.ncbi.nlm.nih.gov/gene/?term=34 "ACAD1, MCAD, MCADH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011172 34 ACADM http://www.ncbi.nlm.nih.gov/gene/?term=34 "ACAD1, MCAD, MCADH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011173 35003 LSm7 http://www.ncbi.nlm.nih.gov/gene/?term=35003 "Dmel_CG13277, BcDNA:RH73529, CG13277, Dmel\CG13277 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011174 35004 BuGZ http://www.ncbi.nlm.nih.gov/gene/?term=35004 "Dmel_CG17912, BcDNA:LD27810, CG17912, Dm_2L:87597, Dmel\CG17912, lincRNA.S1359 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011175 35006 ppk17 http://www.ncbi.nlm.nih.gov/gene/?term=35006 "Dmel_CG13278, CG13278, Dmel\CG13278 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011176 3500 IGHG1 http://www.ncbi.nlm.nih.gov/gene/?term=3500 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011177 35037 beat-IIIc http://www.ncbi.nlm.nih.gov/gene/?term=35037 "Dmel_CG15138, BcDNA:RE14414, Beat-IIIC, Beat-IIIc, CG15138, CG6365, Dmel\CG15138, beat IIIc " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011178 35051 BicD http://www.ncbi.nlm.nih.gov/gene/?term=35051 "Dmel_CG6605, BIC-D, BICD, Bic-D, Bic[D], CG6605, Dmel\CG6605, almond, anon-EST:fe2A11 " mRNA Drosophila melanogaster 17923096 Cell junction Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011179 35051 BicD http://www.ncbi.nlm.nih.gov/gene/?term=35051 "Dmel_CG6605, BIC-D, BICD, Bic-D, Bic[D], CG6605, Dmel\CG6605, almond, anon-EST:fe2A11 " mRNA Drosophila melanogaster 17923096 Cytoskeleton Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011180 35051 BicD http://www.ncbi.nlm.nih.gov/gene/?term=35051 "Dmel_CG6605, BIC-D, BICD, Bic-D, Bic[D], CG6605, Dmel\CG6605, almond, anon-EST:fe2A11 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011181 35051 BicD http://www.ncbi.nlm.nih.gov/gene/?term=35051 "Dmel_CG6605, BIC-D, BICD, Bic-D, Bic[D], CG6605, Dmel\CG6605, almond, anon-EST:fe2A11 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011182 35052 Sgt http://www.ncbi.nlm.nih.gov/gene/?term=35052 "Dmel_CG5094, CG5094, Dmel\CG5094, dsgt " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011183 35053 Aac11 http://www.ncbi.nlm.nih.gov/gene/?term=35053 "Dmel_CG6582, AAC-11, Api5, BcDNA.LD09852, BcDNA:LD09852, CG6582, Dmel\CG6582, l(2)k06710 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011184 35089 CG7200 http://www.ncbi.nlm.nih.gov/gene/?term=35089 Dmel_ Dmel\CG7200 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011185 35097 Fas3 http://www.ncbi.nlm.nih.gov/gene/?term=35097 "Dmel_CG5803, CG5803, Dmel\CG5803, FAS III, FAS3, FASIII, Fas, Fas III, Fas-3, Fas-III, FasIII, FasIIIface, FascIII, fas III, fas-III, fas3, fasIII, fascIII " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011186 35097 Fas3 http://www.ncbi.nlm.nih.gov/gene/?term=35097 "Dmel_CG5803, CG5803, Dmel\CG5803, FAS III, FAS3, FASIII, Fas, Fas III, Fas-3, Fas-III, FasIII, FasIIIface, FascIII, fas III, fas-III, fas3, fasIII, fascIII " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011187 35107 Pde11 http://www.ncbi.nlm.nih.gov/gene/?term=35107 "Dmel_CG34341, CG10231, CG15159, CG34341, Dmel\CG34341, Dmel_CG10231, Dmel_CG15159, PDE11 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011188 35116 MESR3 http://www.ncbi.nlm.nih.gov/gene/?term=35116 "Dmel_CG15162, CG15162, Dmel\CG15162 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011189 35121 msl-1 http://www.ncbi.nlm.nih.gov/gene/?term=35121 "Dmel_CG10385, CG10385, Dmel\CG10385, MSL, MSL-1, MSL1, MSL3, Msl 1-3, Msl-1, Msl1, i94, km(2)B, kmB, mls-1, msl, msl1 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011190 35130 Grip71 http://www.ncbi.nlm.nih.gov/gene/?term=35130 "Dmel_CG10346, CG10346, Dgp71WD, Dgrip71, Dmel\CG10346wd " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011191 35169 hook http://www.ncbi.nlm.nih.gov/gene/?term=35169 "Dmel_CG10653, CG10653, Dmel\CG10653, Hook, dHk, hk " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011192 3516 RBPJ http://www.ncbi.nlm.nih.gov/gene/?term=3516 "AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011193 3516 RBPJ http://www.ncbi.nlm.nih.gov/gene/?term=3516 "AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-JK, RBPSUH, SUH, csl, RBPJ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011194 35173 Acn http://www.ncbi.nlm.nih.gov/gene/?term=35173 "Dmel_CG10473, Ba, CG10437, CG10473, Dmel\CG10473, dAcn, dacn, hkl, l(2)37Ba " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011195 351 APP http://www.ncbi.nlm.nih.gov/gene/?term=351 "AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011196 351 APP http://www.ncbi.nlm.nih.gov/gene/?term=351 "AAA, ABETA, ABPP, AD1I, CTFgamma, CVAP, PN-II, PN2, APP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011197 351 APP http://www.ncbi.nlm.nih.gov/gene/?term=351 "AAA, ABETA, ABPP, AD1I, CTFgamma, CVAP, PN-II, PN2, APP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011198 35215 Pax http://www.ncbi.nlm.nih.gov/gene/?term=35215 "Dmel_CG31794, CG18061, CG18576, CG31794, CT40481, CT42454, DPaxillin, DPxn, DPxn37, Dmel\CG31794, Dpax, DpaxA, PDLP, dPax, pax " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011199 35246 ref(2)P http://www.ncbi.nlm.nih.gov/gene/?term=35246 "Dmel_CG10360, CG10360, Dmel\CG10360, Ref(2)P, Ref(2)p, Ref2P, SQSTM1, p62, p63, refn, ref(2)Po2, ref(2)p, ref2p, ref(2)P " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00011200 35246 ref(2)P http://www.ncbi.nlm.nih.gov/gene/?term=35246 "Dmel_CG10360, CG10360, Dmel\CG10360, Ref(2)P, Ref(2)p, Ref2P, SQSTM1, p62, p63, refn, ref(2)Po2, ref(2)p, ref2p, ref(2)P " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011201 35260 CG10462 http://www.ncbi.nlm.nih.gov/gene/?term=35260 "Dmel_ BcDNA:SD07008, Dmel\CG10462 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00011202 35282 CG10680 http://www.ncbi.nlm.nih.gov/gene/?term=35282 Dmel_ Dmel\CG10680 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011203 35288 lok http://www.ncbi.nlm.nih.gov/gene/?term=35288 "Dmel_CG10895, 10895, 38B.4, CG10895, CHK-2, CHK2, Chk2, DmCHk2, DmChk2, Dmchk2, Dmel\CG10895, Dmnk, Dmnk-L, Dmnk-S, Dmnk/DChk2, LOKI/CHK2, MNK, chk, chk2, chk2/lok, mnk " mRNA Drosophila melanogaster 17923096 Posterior Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011204 35288 lok http://www.ncbi.nlm.nih.gov/gene/?term=35288 "Dmel_CG10895, 10895, 38B.4, CG10895, CHK-2, CHK2, Chk2, DmCHk2, DmChk2, Dmchk2, Dmel\CG10895, Dmnk, Dmnk-L, Dmnk-S, Dmnk/DChk2, LOKI/CHK2, MNK, chk, chk2, chk2/lok, mnk " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011205 35288 lok http://www.ncbi.nlm.nih.gov/gene/?term=35288 "Dmel_CG10895, 10895, 38B.4, CG10895, CHK-2, CHK2, Chk2, DmCHk2, DmChk2, Dmchk2, Dmel\CG10895, Dmnk, Dmnk-L, Dmnk-S, Dmnk/DChk2, LOKI/CHK2, MNK, chk, chk2, chk2/lok, mnk " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011206 35288 lok http://www.ncbi.nlm.nih.gov/gene/?term=35288 "Dmel_CG10895, 10895, 38B.4, CG10895, CHK-2, CHK2, Chk2, DmCHk2, DmChk2, Dmchk2, Dmel\CG10895, Dmnk, Dmnk-L, Dmnk-S, Dmnk/DChk2, LOKI/CHK2, MNK, chk, chk2, chk2/lok, mnk " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011207 352945 BC005685 http://www.ncbi.nlm.nih.gov/gene/?term=352945 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00011208 35311 Arpc2 http://www.ncbi.nlm.nih.gov/gene/?term=35311 "Dmel_CG10954, 38C.47, ARC-P34, ARC-p34, ARPC2, ARPC2/p34, Arc-p34, ArcP34, CG10954, Dmel\CG10954, anon-WO0118547.154, p34 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011209 353133 LCE1C http://www.ncbi.nlm.nih.gov/gene/?term=353133 LEP3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011210 353187 Nr1d2 http://www.ncbi.nlm.nih.gov/gene/?term=353187 "RVR, Rev-erb " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011211 353188 Adam32 http://www.ncbi.nlm.nih.gov/gene/?term=353188 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011212 353208 Zfp931 http://www.ncbi.nlm.nih.gov/gene/?term=353208 2810021G02Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011213 353208 Zfp931 http://www.ncbi.nlm.nih.gov/gene/?term=353208 2810021G02Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00011214 353211 Prune2 http://www.ncbi.nlm.nih.gov/gene/?term=353211 "6330414G02Rik, A230083H22Rik, A330102H22Rik, Bmcc1, mKIAA0367 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011215 353235 Pcdha8 http://www.ncbi.nlm.nih.gov/gene/?term=353235 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011216 353236 Pcdhac1 http://www.ncbi.nlm.nih.gov/gene/?term=353236 CNRc1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011217 353237 Pcdhac2 http://www.ncbi.nlm.nih.gov/gene/?term=353237 CNRc2 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011218 353256 Gtf2i http://www.ncbi.nlm.nih.gov/gene/?term=353256 Gtf2ird1 mRNA Rattus norvegicus 25913238 Dendrite Neuron In situ hybridization These findings support the idea that the G-quadruplex in the 5’UTR of Gtf2i mRNA is involved in the mechanism underlying the targeting of the Gtf2i mRNA to neuronal dendrites and/or local translation in dendrites. RLID00011219 353258 Ltv1 http://www.ncbi.nlm.nih.gov/gene/?term=353258 2610020N02Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011220 353274 ZNF445 http://www.ncbi.nlm.nih.gov/gene/?term=353274 "ZKSCAN15, ZNF168, ZSCAN47 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011221 353274 ZNF445 http://www.ncbi.nlm.nih.gov/gene/?term=353274 "ZKSCAN15, ZNF168, ZSCAN47 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011222 353376 TICAM2 http://www.ncbi.nlm.nih.gov/gene/?term=353376 "MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011223 35341 cad http://www.ncbi.nlm.nih.gov/gene/?term=35341 "Dmel_CG1759, 38E.19, CAD, CG1759, Cad, Dmel\CG1759, S67, anon-WO2004063362.83, cd " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011224 35343 vari http://www.ncbi.nlm.nih.gov/gene/?term=35343 "Dmel_CG9326, 38E.21, CG9326, Dmel\CG9326, Vari, l(2)03953, l(2)03953b, l(2)38EFa, szar " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011225 353500 BMP8A http://www.ncbi.nlm.nih.gov/gene/?term=353500 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011226 353500 BMP8A http://www.ncbi.nlm.nih.gov/gene/?term=353500 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011227 353500 BMP8A http://www.ncbi.nlm.nih.gov/gene/?term=353500 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011228 353502 Hcfc1r1 http://www.ncbi.nlm.nih.gov/gene/?term=353502 HPIP mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011229 35355 CG9336 http://www.ncbi.nlm.nih.gov/gene/?term=35355 "Dmel_ BcDNA:RE71975, Dmel\CG9336 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011230 35379 CG9253 http://www.ncbi.nlm.nih.gov/gene/?term=35379 "Dmel_ DmRH24, Dmel\CG9253, anon-EST:GressD10, cg9253 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011231 3537 IGLC1 http://www.ncbi.nlm.nih.gov/gene/?term=3537 IGLC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011232 35386 CG9246 http://www.ncbi.nlm.nih.gov/gene/?term=35386 Dmel_ Dmel\CG9246 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011233 353 APRT http://www.ncbi.nlm.nih.gov/gene/?term=353 "AMP, APRTD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011234 353 APRT http://www.ncbi.nlm.nih.gov/gene/?term=353 "AMPD, APRT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011235 353 APRT http://www.ncbi.nlm.nih.gov/gene/?term=353 "AMPD, APRT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011236 35400 CG8671 http://www.ncbi.nlm.nih.gov/gene/?term=35400 "Dmel_ Dmel\CG8671, anon-WO0118547.182 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011237 35407 CG8665 http://www.ncbi.nlm.nih.gov/gene/?term=35407 Dmel_ Dmel\CG8665 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011238 35418 Df31 http://www.ncbi.nlm.nih.gov/gene/?term=35418 "Dmel_CG2207, BEST:LD04967, CG2207, DF 31, DF31, Dmel\CG2207, LD04967, anon-EST:Liang-1.46, anon-EST:Posey126, anon-EST:fe1A4, anon-WO0153538.53, anon1A4, clone 1.46, l(2)k05815 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011239 35425 step http://www.ncbi.nlm.nih.gov/gene/?term=35425 "Dmel_CG11628, CG11628, CG11633, CYH1, Dmel\CG11628, GPH, GRP1, GRP1/cytohesin 1, Grp1, Step, cytohesin/GRP1, l(2)SH0323, l(2)SH2 0323, l(2)k08110k, step " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011240 35425 step http://www.ncbi.nlm.nih.gov/gene/?term=35425 "Dmel_CG11628, CG11628, CG11633, CYH1, Dmel\CG11628, GPH, GRP1, GRP1/cytohesin 1, Grp1, Step, cytohesin/GRP1, l(2)SH0323, l(2)SH2 0323, l(2)k08110k, step " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011241 3543 IGLL1 http://www.ncbi.nlm.nih.gov/gene/?term=3543 "14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011242 35454 Tif-IA http://www.ncbi.nlm.nih.gov/gene/?term=35454 "Dmel_CG3278, CG16938, CG3278, CG5951, Dmel\CG3278, TIF-1A, TIF-IA, TIf-IA, Tif-1A, TifIA, dTIF-IA, tif1a " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00011243 35454 Tif-IA http://www.ncbi.nlm.nih.gov/gene/?term=35454 "Dmel_CG3278, CG16938, CG3278, CG5951, Dmel\CG3278, TIF-1A, TIF-IA, TIf-IA, Tif-1A, TifIA, dTIF-IA, tif1a " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011244 35454 Tif-IA http://www.ncbi.nlm.nih.gov/gene/?term=35454 "Dmel_CG3278, CG16938, CG3278, CG5951, Dmel\CG3278, TIF-1A, TIF-IA, TIf-IA, Tif-1A, TifIA, dTIF-IA, tif1a " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011245 35454 Tif-IA http://www.ncbi.nlm.nih.gov/gene/?term=35454 "Dmel_CG3278, CG16938, CG3278, CG5951, Dmel\CG3278, TIF-1A, TIF-IA, TIf-IA, Tif-1A, TifIA, dTIF-IA, tif1a " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011246 3547 IGSF1 http://www.ncbi.nlm.nih.gov/gene/?term=3547 "CHTE, IGCD1, IGDC1, INHBP, PGSF2, p120 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011247 35480 Atf6 http://www.ncbi.nlm.nih.gov/gene/?term=35480 "Dmel_CG3136, ATF6, CG3136, DM15, Dmel\CG3136, atf6 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00011248 35480 Atf6 http://www.ncbi.nlm.nih.gov/gene/?term=35480 "Dmel_CG3136, ATF6, CG3136, DM15, Dmel\CG3136, atf6 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011249 35483 Nipped-A http://www.ncbi.nlm.nih.gov/gene/?term=35483 "Dmel_CG33554, 41Ah, CG10549, CG2905, CG33554, Dmel\CG33554, GroupV, Nip-A, NipA, Nipped A, Nipped[A], TRA1, TRRAP, Tra-1, Tra1, dTRRAP, dTra1, dmTRRAP, l(2)41Ah, l(2)C123, l(2)EMS34-12, tra1 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00011250 35496 CG30440 http://www.ncbi.nlm.nih.gov/gene/?term=35496 "Dmel_ CG10412, CG10416, CG12183, Dmel\CG30440 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011251 35499 CG11665 http://www.ncbi.nlm.nih.gov/gene/?term=35499 Dmel_ Dmel\CG11665 mRNA Drosophila melanogaster 25838129 Perinuclear Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011252 354 KLK3 http://www.ncbi.nlm.nih.gov/gene/?term=354 "APS, KLK2A1, PSA, hK3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011253 35501 Not3 http://www.ncbi.nlm.nih.gov/gene/?term=35501 "Dmel_CG8426, CG8426, CNOT3, Dmel\CG8426, NOT3, NOT3.5, NOT3/5, l(2)NC136, not3, not3/5 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00011254 35505 scaf http://www.ncbi.nlm.nih.gov/gene/?term=35505 "Dmel_CG11066, CG11066, CG15900, Dmel\CG11066, SPH142, scarf " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011255 35505 scaf http://www.ncbi.nlm.nih.gov/gene/?term=35505 "Dmel_CG11066, CG11066, CG15900, Dmel\CG11066, SPH142, scarf " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011256 3550 IK http://www.ncbi.nlm.nih.gov/gene/?term=3550 "CSA2, RED " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011257 3551 IKBKB http://www.ncbi.nlm.nih.gov/gene/?term=3551 "IKK-beta, IKK2, IKKB, IMD15, NFKBIKB " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011258 35546 Ptr http://www.ncbi.nlm.nih.gov/gene/?term=35546 "Dmel_CG11212, CG11212, Dmel\CG11212, Dmptr_Dm, ptc-related-gene, ptr, Ptr " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011259 3554 IL1R1 http://www.ncbi.nlm.nih.gov/gene/?term=3554 "CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011260 3556 IL1RAP http://www.ncbi.nlm.nih.gov/gene/?term=3556 "C3orf13, IL-1RAcP, IL1R3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011261 3557 IL1RN http://www.ncbi.nlm.nih.gov/gene/?term=3557 "DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011262 35584 Eb1 http://www.ncbi.nlm.nih.gov/gene/?term=35584 "Dmel_CG3265, BcDNA.LD08743, BcDNA:LD08743, CG3265, Dm EB1, DmEB1, Dmel\CG3265, EB-1, EB1, S(DmcycE[JP])2.5, anon-EST:Liang-2.33, anon-EST:Liang-2.52, clone 2.33, clone 2.52, dEB-1, dEB1, d eb1, l(2)04524, l(2)4524 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011263 35588 Epac http://www.ncbi.nlm.nih.gov/gene/?term=35588 "Dmel_CG34392, CG15235, CG3427, CG34392, D-EPAC, D-Epac, Dm_2R:10367, Dmel\CG34392, Dmel_CG15235, Dmel_CG3427, epac " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011264 3561 IL2RG http://www.ncbi.nlm.nih.gov/gene/?term=3561 "CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011265 35654 Dhx15 http://www.ncbi.nlm.nih.gov/gene/?term=35654 "Dmel_CG11107, CG11107, DHX15, Dmel\CG11107, anon-EST:Liang-1.18, cg11107, clone 1.18 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011266 35660 Eaf http://www.ncbi.nlm.nih.gov/gene/?term=35660 "Dmel_CG11166, CG11166, CG1706, Dmel\CG11166, EP(2)2475, LD35207, dEaf " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011267 35660 Eaf http://www.ncbi.nlm.nih.gov/gene/?term=35660 "Dmel_CG11166, CG11166, CG1706, Dmel\CG11166, EP(2)2475, LD35207, dEaf " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011268 3566 IL4R http://www.ncbi.nlm.nih.gov/gene/?term=3566 "CD124, IL-4RA, IL4RA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011269 35696 scra http://www.ncbi.nlm.nih.gov/gene/?term=35696 "Dmel_CG2092, ABP8, Abp8, Ani, Anil, Anillin, CG2092, Dmel\CG2092, Scra, ani, anil, anillin, l(2)03427, l(2)43Ec, l(2)k08255 " mRNA Drosophila melanogaster 17923096 Cell junction Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011270 35696 scra http://www.ncbi.nlm.nih.gov/gene/?term=35696 "Dmel_CG2092, ABP8, Abp8, Ani, Anil, Anillin, CG2092, Dmel\CG2092, Scra, ani, anil, anillin, l(2)03427, l(2)43Ec, l(2)k08255 " mRNA Drosophila melanogaster 17923096 Cytoskeleton Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011271 35696 scra http://www.ncbi.nlm.nih.gov/gene/?term=35696 "Dmel_CG2092, ABP8, Abp8, Ani, Anil, Anillin, CG2092, Dmel\CG2092, Scra, ani, anil, anillin, l(2)03427, l(2)43Ec, l(2)k08255 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011272 3569 IL6 http://www.ncbi.nlm.nih.gov/gene/?term=3569 "BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011273 3569 IL6 http://www.ncbi.nlm.nih.gov/gene/?term=3569 "BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6 " mRNA Homo sapiens 26000482 Ribosome HeLa cell qRT-PCR "Knockdown of Reg1 resulted in a large increase in IL6 and PTGS2 mRNA expression in the polysome fractions (fractions 7-12) compared with control cells, whereas the mRNA in non-polysome fractions (fractions 3-6) were comparable (Figure 3 H). " RLID00011274 3570 IL6R http://www.ncbi.nlm.nih.gov/gene/?term=3570 "CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011275 35717 tor http://www.ncbi.nlm.nih.gov/gene/?term=35717 "Dmel_CG1389, CG1389, Dmel\CG1389, TOR, Tor, Torso, splc " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011276 3572 IL6ST http://www.ncbi.nlm.nih.gov/gene/?term=3572 "CD130, CDW130, GP130, IL-6RB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011277 3572 IL6ST http://www.ncbi.nlm.nih.gov/gene/?term=3572 "CD130, CDW130, GP130, IL-6RB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011278 35731 sax http://www.ncbi.nlm.nih.gov/gene/?term=35731 "Dmel_CG1891, Bkr43E, Brk43E, CG1891, Dmel\CG1891, SAX, STK-B, Sa, Sax " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011279 3575 IL7R http://www.ncbi.nlm.nih.gov/gene/?term=3575 "CD127, CDW127, IL-7R-alpha, IL7RA, ILRA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011280 3575 IL7R http://www.ncbi.nlm.nih.gov/gene/?term=3575 "CD127, CDW127, IL-7R-alphaA, ILRA, IL7R " lncRNA Homo sapiens 24723426 Nucleus Monocytic cell line Northern blot|RT-PCR|Microarray "To do this, we measured levels of lnc-IL7R in nuclear and cytoplasmic fractions of LPS treated cells. We found that a majority of lnc-IL7R was present in nuclei (Fig. 2C). " RLID00011281 35781 udd http://www.ncbi.nlm.nih.gov/gene/?term=35781 "Dmel_CG18316, CG18316, Dmel\CG18316, Udd " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011282 35781 udd http://www.ncbi.nlm.nih.gov/gene/?term=35781 "Dmel_CG18316, CG18316, Dmel\CG18316, Udd " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011283 35843 rgr http://www.ncbi.nlm.nih.gov/gene/?term=35843 "Dmel_CG8643, CG14751, CG8643, Dmel\CG8643, l(2)k02605 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00011284 35864 gcl http://www.ncbi.nlm.nih.gov/gene/?term=35864 "Dmel_CG8411, CG8411, Dmel\CG8411, GCL, Gcl-1, gcl " mRNA Drosophila melanogaster 15852043 Germ plasm Oocyte - "MRNAs can also become localized by passively diffusing through the cytoplasm until they are trapped by a localized anchor. Several transcripts, such as nanos, gcl (germ cell-less) and Cyclin B mRNAs, become enriched in the D. melanogaster pole plasm in this way " RLID00011285 35864 gcl http://www.ncbi.nlm.nih.gov/gene/?term=35864 "Dmel_CG8411, CG8411, Dmel\CG8411, GCL, Gcl-1, gcl " mRNA Drosophila melanogaster 26242323 Germ plasm Embryo Fluorescence in situ hybridization "Next we determined the distribution of the known germ plasm enriched mRNAs cycB, nos, pgc, gcl and oskar (osk) and one control mRNAccr4, which appears evenly distributed throughout the embryo4 (Fig. 2a,b,h). " RLID00011286 35864 gcl http://www.ncbi.nlm.nih.gov/gene/?term=35864 "Dmel_CG8411, CG8411, Dmel\CG8411, GCL, Gcl-1, gcl " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011287 35865 stmA http://www.ncbi.nlm.nih.gov/gene/?term=35865 "Dmel_CG8739, CG8739, Dmel\CG8739, cmp44E, rbo, stambhA, stm-A " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011288 3588 IL10RB http://www.ncbi.nlm.nih.gov/gene/?term=3588 "CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011289 3589 IL11 http://www.ncbi.nlm.nih.gov/gene/?term=3589 "AGIF, IL-11 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011290 3589 IL11 http://www.ncbi.nlm.nih.gov/gene/?term=3589 "AGIF, IL-11 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011291 358 AQP1 http://www.ncbi.nlm.nih.gov/gene/?term=358 "AQP-CHIP, CHIP28, CO " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011292 358 AQP1 http://www.ncbi.nlm.nih.gov/gene/?term=358 "AQP-CHIP, CHIP28, CO " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00011293 358 AQP1 http://www.ncbi.nlm.nih.gov/gene/?term=358 "AQP-CHIP, CHIP28, CO " mRNA Homo sapiens 12923260 Endoplasmic reticulum Jurkat cell Microarray|Northern blot "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00011294 35909 Ance-4 http://www.ncbi.nlm.nih.gov/gene/?term=35909 "Dmel_CG8196, CG8196, Dmel\CG8196, ance-4 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011295 3590 IL11RA http://www.ncbi.nlm.nih.gov/gene/?term=3590 CRSDA mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011296 35927 Su(var)2-10 http://www.ncbi.nlm.nih.gov/gene/?term=35927 "Dmel_CG8068, CG8068, CLOT2057, DPIAS, DmPias, Dmel\CG8068, Dpias, PIAS, SU(VAR)2-10, Su(Var)2-10, Su(var)-10, Su-var(2)10, Suvar(2)10, ZIMP, ZimpA, ZimpB, dPIAS, dpias, i184, l(2)03697, pias, zimp " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011297 35929 CG18659 http://www.ncbi.nlm.nih.gov/gene/?term=35929 "Dmel_ BcDNA:GH08789, CG30347, CG30348, CG8059, Dmel\CG18659, anon-WO0118547.140, anon-WO0118547.145 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011298 35940 Rab32 http://www.ncbi.nlm.nih.gov/gene/?term=35940 "Dmel_CG8024, 24652026, 24652028, A1Z7S1, CG8024, DRABR1, DmRab32, Dmel\CG8024, DrabRP1, RAB-RP1, Rab-RP1, Rab-RP1/CG8024, Rab-r1/RP1, Rab7L1, RabRP1, anon-WO0118547.106, beck, ltd, rab32 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011299 35941 CG8026 http://www.ncbi.nlm.nih.gov/gene/?term=35941 "Dmel_ Dmel\CG8026, Dromel_CG8026_FBtr0088611_mORF, anon-WO0242455.53, anon-WO0242455.6, anon-WO0242455.7 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011300 3594 IL12RB1 http://www.ncbi.nlm.nih.gov/gene/?term=3594 "CD212, IL-12R-BETA1, IL12RB, IMD30 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011301 3594 IL12RB1 http://www.ncbi.nlm.nih.gov/gene/?term=3594 "CD212, IL-12R-BETA1, IL12RB, IMD30 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011302 35955 Drep2 http://www.ncbi.nlm.nih.gov/gene/?term=35955 "Dmel_CG1975, CG1975, DREP-2, Dmel\CG1975, Drep-2, Rep2, anon-WO0118547.162, anon-WO0118547.168, drep2, rep2 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011303 35955 Drep2 http://www.ncbi.nlm.nih.gov/gene/?term=35955 "Dmel_CG1975, CG1975, DREP-2, Dmel\CG1975, Drep-2, Rep2, anon-WO0118547.162, anon-WO0118547.168, drep2, rep2 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011304 35956 Myd88 http://www.ncbi.nlm.nih.gov/gene/?term=35956 "Dmel_CG2078, CG2078, DMMYD88, DmMyD88, DmMyd88, Dmel\CG2078, EP(2)2535, Kra, LD20892, MYD88, MyD88F, dMYd88, dMyD88, dMyd88, kra, myd88 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011305 35963 Non1 http://www.ncbi.nlm.nih.gov/gene/?term=35963 "Dmel_CG8801, BcDNA:LD23830, CG30341, CG8801, Dmel\CG8801, LD23830 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011306 35963 Non1 http://www.ncbi.nlm.nih.gov/gene/?term=35963 "Dmel_CG8801, BcDNA:LD23830, CG30341, CG8801, Dmel\CG8801, LD23830 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011307 35970 Pdk http://www.ncbi.nlm.nih.gov/gene/?term=35970 "Dmel_CG8808, BcDNA:LD09837, CG8808, DmPDK, DmPdk, Dmel\CG8808, PDK, pdk " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011308 35971 ced-6 http://www.ncbi.nlm.nih.gov/gene/?term=35971 "Dmel_CG11804, CG11804, Ced-6, Dmel\CG11804, ced6, dCed-6, d drCed-6, drced-6 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011309 3597 IL13RA1 http://www.ncbi.nlm.nih.gov/gene/?term=3597 "CD213A1, CT19, IL-13Ra, NR4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011310 3597 IL13RA1 http://www.ncbi.nlm.nih.gov/gene/?term=3597 "CD213A1, CT19, IL-13Ra, NR4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011311 359845 FAM101B http://www.ncbi.nlm.nih.gov/gene/?term=359845 CFM1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011312 359948 IRF2BP2 http://www.ncbi.nlm.nih.gov/gene/?term=359948 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011313 359 AQP2 http://www.ncbi.nlm.nih.gov/gene/?term=359 "AQP-CD, WCH-CD " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00011314 35 ACADS http://www.ncbi.nlm.nih.gov/gene/?term=35 "ACAD3, SCAD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011315 35 ACADS http://www.ncbi.nlm.nih.gov/gene/?term=35 "ACAD3, SCAD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011316 360023 ZBTB41 http://www.ncbi.nlm.nih.gov/gene/?term=360023 "FRBZ1, ZNF924 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011317 36006 CG1698 http://www.ncbi.nlm.nih.gov/gene/?term=36006 "Dmel_ DmNAT5, Dmel\CG1698 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011318 360155 CYCSP52 http://www.ncbi.nlm.nih.gov/gene/?term=360155 "HC6, HCP2 " lncRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00011319 3601 IL15RA http://www.ncbi.nlm.nih.gov/gene/?term=3601 CD215 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011320 36039 eve http://www.ncbi.nlm.nih.gov/gene/?term=36039 "Dmel_CG2328, 10.5, 10.9, 14.10, 20.35, CG2328, Dmel\CG2328, E(eve), EVE, Eve, F, V, VI, dm-eve2, even, l(2)46CFg, l(2)46CFh, l(2)46CFj, l(2)46CFp, l(2)46Ce, l(2)46Cg, eve " mRNA Drosophila melanogaster 15280214 Basal Embryo In situ hybridization "Whereas embryos laid by wild-type mothers have an almost exclusively apical distribution of pair-rule mRNAs such as eve, ftz, h and runt (run), those laid by egl3e/eglWU50 mothers accumulate a large proportion of these transcripts in the basal cytoplasm (Fig. 5A). " RLID00011321 36041 Pka-R2 http://www.ncbi.nlm.nih.gov/gene/?term=36041 "Dmel_CG15862, BcDNA:GM01761, CG15862, Cos, Cos-1, Cos1, Dmel\CG15862, Epa, PKA, PKA RII, PKA-R2, PKA-RII, PKa-R2, Pka-RII, RII, RII[[DR]], cos1, pkA, pka-RII " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011322 36041 Pka-R2 http://www.ncbi.nlm.nih.gov/gene/?term=36041 "Dmel_CG15862, BcDNA:GM01761, CG15862, Cos, Cos-1, Cos1, Dmel\CG15862, Epa, PKA, PKA RII, PKA-R2, PKA-RII, PKa-R2, Pka-RII, RII, RII[[DR]], cos1, pkA, pka-RII " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011323 36042 CG12128 http://www.ncbi.nlm.nih.gov/gene/?term=36042 Dmel_ Dmel\CG12128 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011324 3604 TNFRSF9 http://www.ncbi.nlm.nih.gov/gene/?term=3604 "4-1BB, CD137, CDw137, ILA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011325 3604 TNFRSF9 http://www.ncbi.nlm.nih.gov/gene/?term=3604 "4-1BB, CD137, CDw137, ILA " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011326 36064 gem http://www.ncbi.nlm.nih.gov/gene/?term=36064 "Dmel_CG30011, BcDNA:HL07889, CG11867, CG30011, CG3459, Dmel\CG30011, anon-AE003830.1, dCP2 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011327 36064 gem http://www.ncbi.nlm.nih.gov/gene/?term=36064 "Dmel_CG30011, BcDNA:HL07889, CG11867, CG30011, CG3459, Dmel\CG30011, anon-AE003830.1, dCP2 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011328 3607 FOXK2 http://www.ncbi.nlm.nih.gov/gene/?term=3607 "ILF, ILF-1, ILF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011329 3608 ILF2 http://www.ncbi.nlm.nih.gov/gene/?term=3608 "NF45, PRO3063 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011330 3608 ILF2 http://www.ncbi.nlm.nih.gov/gene/?term=3608 "NF45, PRO3063 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011331 36095 Ir47a http://www.ncbi.nlm.nih.gov/gene/?term=36095 "Dmel_CG12900, CG12900, CG12900/CG34363, DmelIR47a, Dmel\CG12900, IR47a " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011332 3609 ILF3 http://www.ncbi.nlm.nih.gov/gene/?term=3609 "CBTF, DRBF, DRBP76, MMP4, MPHOSPH4, MPP4, NF-AT-90, NF110, NF110b, NF90, NF90a, NF90b, NFAR, NFAR-1, NFAR2, TCP110, TCP80 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011333 3609 ILF3 http://www.ncbi.nlm.nih.gov/gene/?term=3609 "CBTF, DRBF, DRBP76, MMP4, MPHOSPH4, MPP4, NF-AT-90, NF110, NF110b, NF90, NF90a, NF90b, NFAR, NFAR-1, NFAR2, TCP110, TCP80 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011334 360 AQP3 http://www.ncbi.nlm.nih.gov/gene/?term=360 "AQP-3, GIL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011335 360 AQP3 http://www.ncbi.nlm.nih.gov/gene/?term=360 "AQP-3, GIL " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00011336 3611 ILK http://www.ncbi.nlm.nih.gov/gene/?term=3611 "HEL-S-28, ILK-1, ILK-2, P59, p59ILK " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011337 3611 ILK http://www.ncbi.nlm.nih.gov/gene/?term=3611 "HEL-S-28-1, ILK-2, P59, p59ILK, ILK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011338 3611 ILK http://www.ncbi.nlm.nih.gov/gene/?term=3611 "HEL-S-28-1, ILK-2, P59, p59ILK, ILK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011339 3612 IMPA1 http://www.ncbi.nlm.nih.gov/gene/?term=3612 "IMP, IMPA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011340 3612 IMPA1 http://www.ncbi.nlm.nih.gov/gene/?term=3612 "IMP, IMPA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011341 3613 IMPA2 http://www.ncbi.nlm.nih.gov/gene/?term=3613 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011342 3613 IMPA2 http://www.ncbi.nlm.nih.gov/gene/?term=3613 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011343 36142 RpS15Ab http://www.ncbi.nlm.nih.gov/gene/?term=36142 "Dmel_CG12324, CG12324, CT22283, Dmel\CG12324, RpS15A " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011344 3614 IMPDH1 http://www.ncbi.nlm.nih.gov/gene/?term=3614 "IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011345 3614 IMPDH1 http://www.ncbi.nlm.nih.gov/gene/?term=3614 "IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011346 36154 CG18004 http://www.ncbi.nlm.nih.gov/gene/?term=36154 Dmel_ Dmel\CG18004 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011347 3615 IMPDH2 http://www.ncbi.nlm.nih.gov/gene/?term=3615 "IMPD2, IMPDH-II " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011348 361 AQP4 http://www.ncbi.nlm.nih.gov/gene/?term=361 "MIWC, WCH4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011349 361 AQP4 http://www.ncbi.nlm.nih.gov/gene/?term=361 "MIWC, WCH4 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00011350 3620 IDO1 http://www.ncbi.nlm.nih.gov/gene/?term=3620 "IDO, IDO-1, INDO " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011351 362161 Rapsn http://www.ncbi.nlm.nih.gov/gene/?term=362161 rapsyn mRNA Rattus norvegicus 7599960 Synapse Muscle fibers In situ hybridization "N-CAM, 44K-rapsyn, and S-laminin mRNAs are concentrated at synaptic sites in muscle fibers. " RLID00011352 3621 ING1 http://www.ncbi.nlm.nih.gov/gene/?term=3621 "p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011353 36237 CG7777 http://www.ncbi.nlm.nih.gov/gene/?term=36237 "Dmel_ Aqp7777, Dmel\CG7777 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011354 36248 Tret1-1 http://www.ncbi.nlm.nih.gov/gene/?term=36248 "Dmel_CG30035, CG30035, CG7797, CG7801, DmTret1-1, Dmel\CG30035, Tre T1 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011355 36249 Tret1-2 http://www.ncbi.nlm.nih.gov/gene/?term=36249 "Dmel_CG8234, CG8234, DmTret1-2, Dmel\CG8234 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011356 36249 Tret1-2 http://www.ncbi.nlm.nih.gov/gene/?term=36249 "Dmel_CG8234, CG8234, DmTret1-2, Dmel\CG8234 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011357 3624 INHBA http://www.ncbi.nlm.nih.gov/gene/?term=3624 "EDF, FRP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011358 3625 INHBB http://www.ncbi.nlm.nih.gov/gene/?term=3625 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011359 36260 Sobp http://www.ncbi.nlm.nih.gov/gene/?term=36260 "Dmel_CG8991, CG8991, Dmel\CG8991, Sbp " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011360 362631 Rpl11 http://www.ncbi.nlm.nih.gov/gene/?term=362631 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00011361 362636 Usp48 http://www.ncbi.nlm.nih.gov/gene/?term=362636 "Usp31, synUSP " mRNA Rattus norvegicus 14535949 Dendrite Hippocampus In situ hybridization "The mRNA for synUSP was localized to dendrites, as well as somas, of neuronal cells. The dendritic localization of the synUSP mRNAs was thus confirmed in the brain section. " RLID00011362 362636 Usp48 http://www.ncbi.nlm.nih.gov/gene/?term=362636 "Usp31, synUSP " mRNA Rattus norvegicus 14535949 Synapse Hippocampus In situ hybridization "A novel ubiquitin-specific protease, synUSP, is localized at the post-synaptic density and post-synaptic lipid raft. " RLID00011363 36270 ERp60 http://www.ncbi.nlm.nih.gov/gene/?term=36270 "Dmel_CG8983, CG8983, D- Dmel\CG8983, Erp60, Ov6, anon-EST:fe3D9 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011364 36270 ERp60 http://www.ncbi.nlm.nih.gov/gene/?term=36270 "Dmel_CG8983, CG8983, D- Dmel\CG8983, Erp60, Ov6, anon-EST:fe3D9 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011365 362 AQP5 http://www.ncbi.nlm.nih.gov/gene/?term=362 "AQP-5, PPKB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011366 362 AQP5 http://www.ncbi.nlm.nih.gov/gene/?term=362 "AQP-5, PPKB " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00011367 3631 INPP4A http://www.ncbi.nlm.nih.gov/gene/?term=3631 "INPP4, TVAS1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011368 3633 INPP5B http://www.ncbi.nlm.nih.gov/gene/?term=3633 5PTase mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011369 3633 INPP5B http://www.ncbi.nlm.nih.gov/gene/?term=3633 5PTase mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011370 3633 INPP5B http://www.ncbi.nlm.nih.gov/gene/?term=3633 5PTase mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011371 36340 CG8839 http://www.ncbi.nlm.nih.gov/gene/?term=36340 Dmel_ Dmel\CG8839 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011372 3635 INPP5D http://www.ncbi.nlm.nih.gov/gene/?term=3635 "SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011373 3636 INPPL1 http://www.ncbi.nlm.nih.gov/gene/?term=3636 "OPSMD, SHIP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011374 3636 INPPL1 http://www.ncbi.nlm.nih.gov/gene/?term=3636 "OPSMD, SHIP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011375 3636 INPPL1 http://www.ncbi.nlm.nih.gov/gene/?term=3636 "OPSMD, SHIP2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011376 36383 Amph http://www.ncbi.nlm.nih.gov/gene/?term=36383 "Dmel_CG8604, Amp, CG8604, DAMP, Damp, Dmel\CG8604, amph, dAmp, dAmph, damph " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011377 3638 INSIG1 http://www.ncbi.nlm.nih.gov/gene/?term=3638 "CL-6, CL6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011378 3638 INSIG1 http://www.ncbi.nlm.nih.gov/gene/?term=3638 "CL-6, CL6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011379 3638 INSIG1 http://www.ncbi.nlm.nih.gov/gene/?term=3638 "CL-6, CL6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011380 363 AQP6 http://www.ncbi.nlm.nih.gov/gene/?term=363 "AQP2L, KID " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00011381 363 AQP6 http://www.ncbi.nlm.nih.gov/gene/?term=363 "AQP2L, KID " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011382 363 AQP6 http://www.ncbi.nlm.nih.gov/gene/?term=363 "AQP2L, KID " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011383 3640 INSL3 http://www.ncbi.nlm.nih.gov/gene/?term=3640 "RLF, RLNL, ley-I-L " mRNA Homo sapiens 22679391 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "Figure 2: ALPP and CALR, but not t-ftz or INSL3, mRNA remain associated with the ER independently of ribosomes and translation. (A–E) COS-7 cells were transfected with plasmids containing either the t-ftz (A), INSL3 (A–B), ALPP (A, C), cyto-ALPP (a version of ALPP lacking signal sequence and transmembrane domain coding regions; A, D–E), or CALR (A) genes and allowed to express mRNA for 18â€?4 h. The cells were then treated with DMSO (Cont), puromycin, or HHT for 30 min, and then extracted with digitonin alone or with 20 mM EDTA. Cells were then fixed, stained for mRNA using specific FISH probes, and imaged (see panels B–D for examples). The fluorescence intensities of mRNA in the ER and nucleus in the micrographs were quantified (A). Each bar represents the average and standard error of three independent experiments, each consisting of the average integrated intensity of 30 cells over background. Note that although ribosome disruption caused INSL3 mRNA to dissociate from the ER, the nuclear mRNA was unaffected (B, nuclei are denoted by arrows). (E) A single field of view containing a single HHT-treated, digitonin-extracted, COS-7 cell expressing cyto-ALPP mRNA. cyto-ALPP mRNA was visualized by FISH and for Trapα protein by immunofluorescence. Note the extensive co-localization of cyto-ALPP mRNA (red) and Trapα (green) in the overlay. All scale bars?=?20 um. Data are collected from Figure 2. " RLID00011384 3640 INSL3 http://www.ncbi.nlm.nih.gov/gene/?term=3640 "RLF, RLNL, ley-I-L " mRNA Homo sapiens 22679391 Nucleus COS-7 cell Fluorescence in situ hybridization "Figure 2: ALPP and CALR, but not t-ftz or INSL3, mRNA remain associated with the ER independently of ribosomes and translation. (A–E) COS-7 cells were transfected with plasmids containing either the t-ftz (A), INSL3 (A–B), ALPP (A, C), cyto-ALPP (a version of ALPP lacking signal sequence and transmembrane domain coding regions; A, D–E), or CALR (A) genes and allowed to express mRNA for 18â€?4 h. The cells were then treated with DMSO (Cont), puromycin, or HHT for 30 min, and then extracted with digitonin alone or with 20 mM EDTA. Cells were then fixed, stained for mRNA using specific FISH probes, and imaged (see panels B–D for examples). The fluorescence intensities of mRNA in the ER and nucleus in the micrographs were quantified (A). Each bar represents the average and standard error of three independent experiments, each consisting of the average integrated intensity of 30 cells over background. Note that although ribosome disruption caused INSL3 mRNA to dissociate from the ER, the nuclear mRNA was unaffected (B, nuclei are denoted by arrows). (E) A single field of view containing a single HHT-treated, digitonin-extracted, COS-7 cell expressing cyto-ALPP mRNA. cyto-ALPP mRNA was visualized by FISH and for Trapα protein by immunofluorescence. Note the extensive co-localization of cyto-ALPP mRNA (red) and Trapα (green) in the overlay. All scale bars?=?20 um. Data are collected from Figure 2. " RLID00011385 36411 sca http://www.ncbi.nlm.nih.gov/gene/?term=36411 "Dmel_CG17579, AAA28880, AAF58455, CG17579, Dmel\CG17579, FBpp0086968, FBpp0086969, Sca, Sca1b, anon-EST:Liang-38, clone 38, mAb sca1 " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011386 3642 INSM1 http://www.ncbi.nlm.nih.gov/gene/?term=3642 "IA-1, IA1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011387 36436 Drl-2 http://www.ncbi.nlm.nih.gov/gene/?term=36436 "Dmel_CG3915, CG12463, CG3915, DNT-like, DRL-2, Dmel\CG3915, dnl, drl-2 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011388 3643 INSR http://www.ncbi.nlm.nih.gov/gene/?term=3643 "CD220, HHF5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011389 3643 INSR http://www.ncbi.nlm.nih.gov/gene/?term=3643 "CD220, HHF5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011390 36460 Fsn http://www.ncbi.nlm.nih.gov/gene/?term=36460 "Dmel_CG4643, BEST:GH20696, CG4643, DFsn, Dmel\CG4643, FBXO2, Wals, dFsn, fsn " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011391 36466 CG4679 http://www.ncbi.nlm.nih.gov/gene/?term=36466 "Dmel_ Dmel\CG4679, RE17985p " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011392 3646 EIF3E http://www.ncbi.nlm.nih.gov/gene/?term=3646 "EIF3-P48, EIF3S6, INT6, eIF3-p46 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011393 3646 EIF3E http://www.ncbi.nlm.nih.gov/gene/?term=3646 "EIF3-P48, EIF3S6, INT6, eIF3-p46 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011394 3646 EIF3E http://www.ncbi.nlm.nih.gov/gene/?term=3646 "EIF3-P48, EIF3S6, INT6, eIF3-p46 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011395 364 AQP7 http://www.ncbi.nlm.nih.gov/gene/?term=364 "AQP7L, AQPap, GLYCQTL " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00011396 3652 IPP http://www.ncbi.nlm.nih.gov/gene/?term=3652 KLHL27 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011397 3652 IPP http://www.ncbi.nlm.nih.gov/gene/?term=3652 KLHL27 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011398 36542 shot http://www.ncbi.nlm.nih.gov/gene/?term=36542 "Dmel_CG18076, 42/4, CG18076, CG18637, Dmel\CG18076, Grv, Shot, Su(Mir)1, grv, kak, kop, l(2)CA4, l(2)k03010, l(2)k04204, l(2)k05434, l(2)k05821, l(2)k10821, l(2)k15606, shortstop/kakapo " mRNA Drosophila melanogaster 17923096 Cell junction Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011399 36542 shot http://www.ncbi.nlm.nih.gov/gene/?term=36542 "Dmel_CG18076, 42/4, CG18076, CG18637, Dmel\CG18076, Grv, Shot, Su(Mir)1, grv, kak, kop, l(2)CA4, l(2)k03010, l(2)k04204, l(2)k05434, l(2)k05821, l(2)k10821, l(2)k15606, shortstop/kakapo " mRNA Drosophila melanogaster 17923096 Cytoskeleton Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011400 3654 IRAK1 http://www.ncbi.nlm.nih.gov/gene/?term=3654 "IRAK, pelle " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011401 3654 IRAK1 http://www.ncbi.nlm.nih.gov/gene/?term=3654 "IRAK, pelle " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011402 3655 ITGA6 http://www.ncbi.nlm.nih.gov/gene/?term=3655 "CD49fB, VLA-6, ITGA6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011403 3656 IRAK2 http://www.ncbi.nlm.nih.gov/gene/?term=3656 IRAK-2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011404 3656 IRAK2 http://www.ncbi.nlm.nih.gov/gene/?term=3656 IRAK-2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011405 36578 Opa1 http://www.ncbi.nlm.nih.gov/gene/?term=36578 "Dmel_CG8479, CG8479, Dmel\CG8479, OPA1, OPA1-like-like, dOPA1, dOpa1, l(2)s3475, opa1, opa1-like, Opa1 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011406 36578 Opa1 http://www.ncbi.nlm.nih.gov/gene/?term=36578 "Dmel_CG8479, CG8479, Dmel\CG8479, OPA1, OPA1-like-like, dOPA1, dOpa1, l(2)s3475, opa1, opa1-like, Opa1 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011407 36578 Opa1 http://www.ncbi.nlm.nih.gov/gene/?term=36578 "Dmel_CG8479, CG8479, Dmel\CG8479, OPA1, OPA1-like-like, dOPA1, dOpa1, l(2)s3475, opa1, opa1-like, Opa1 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011408 36581 CG8503 http://www.ncbi.nlm.nih.gov/gene/?term=36581 Dmel_ Dmel\CG8503 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011409 3658 IREB2 http://www.ncbi.nlm.nih.gov/gene/?term=3658 "ACO3, IRP2, IRP2AD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011410 3658 IREB2 http://www.ncbi.nlm.nih.gov/gene/?term=3658 "ACO3, IRP2, IRP2AD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011411 3658 IREB2 http://www.ncbi.nlm.nih.gov/gene/?term=3658 "ACO3, IRP2, IRP2AD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011412 3658 IREB2 http://www.ncbi.nlm.nih.gov/gene/?term=3658 "ACO3, IRP2, IRP2AD " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011413 3658 IREB2 http://www.ncbi.nlm.nih.gov/gene/?term=3658 "ACO3, IRP2, IRP2AD " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011414 36592 Shroom http://www.ncbi.nlm.nih.gov/gene/?term=36592 "Dmel_CG34379, CG13942, CG13944, CG34379, CG8603, Dmel\CG34379, Dmel_CG13942, Dmel_CG8603, Shrm, dShrm, dm " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011415 3659 IRF1 http://www.ncbi.nlm.nih.gov/gene/?term=3659 "IRF-1, MAR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011416 3659 IRF1 http://www.ncbi.nlm.nih.gov/gene/?term=3659 "IRF-1, MAR " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011417 36606 phyl http://www.ncbi.nlm.nih.gov/gene/?term=36606 "Dmel_CG10108, CG10108, D(DmcycE[JP])2.2, Dmel\CG10108, PHYL, Phyl, SR2-3, Su(Raf)2C, phy1 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011418 3660 IRF2 http://www.ncbi.nlm.nih.gov/gene/?term=3660 IRF-2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011419 3661 IRF3 http://www.ncbi.nlm.nih.gov/gene/?term=3661 IIAE7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011420 3661 IRF3 http://www.ncbi.nlm.nih.gov/gene/?term=3661 IIAE7 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011421 3665 IRF7 http://www.ncbi.nlm.nih.gov/gene/?term=3665 "IMD39, IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011422 366624 Cfl2 http://www.ncbi.nlm.nih.gov/gene/?term=366624 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00011423 36668 Kank http://www.ncbi.nlm.nih.gov/gene/?term=36668 "Dmel_CG10249, BEST:GH19041, BcDNA:GH03482, CG10249, Dmel\CG10249, kank " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011424 36668 Kank http://www.ncbi.nlm.nih.gov/gene/?term=36668 "Dmel_CG10249, BEST:GH19041, BcDNA:GH03482, CG10249, Dmel\CG10249, kank " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011425 36668 Kank http://www.ncbi.nlm.nih.gov/gene/?term=36668 "Dmel_CG10249, BEST:GH19041, BcDNA:GH03482, CG10249, Dmel\CG10249, kank " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011426 36676 CG10265 http://www.ncbi.nlm.nih.gov/gene/?term=36676 "Dmel_ CG30474, Dmel\CG10265 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011427 3667 IRS1 http://www.ncbi.nlm.nih.gov/gene/?term=3667 HIRS-1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011428 3667 IRS1 http://www.ncbi.nlm.nih.gov/gene/?term=3667 HIRS-1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011429 36692 scb http://www.ncbi.nlm.nih.gov/gene/?term=36692 "Dmel_CG8095, CG8095, CT21280, CT36929, Dm0620, Dmel\CG8095, E(Sev-CycE)E93, E(sev-cycE)[e93], ItgaPS3, PS3, Vol, aPS3, alpha-PS3, alphaInt3, alphaPS3, alpha[[PS3]], beta[[PS3], l(2)01288, vol " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011430 36697 Xpc http://www.ncbi.nlm.nih.gov/gene/?term=36697 "Dmel_CG8153, CG8153, DhR4, DhXPC, DmXPC, Dmel\CG8153, Mus 210, Mus210, XPC[DM]c, mus(2)201, mus(2)201G1, mus(2)201[GI], mus201[G1], mus210, mus212, Xpc " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011431 36697 Xpc http://www.ncbi.nlm.nih.gov/gene/?term=36697 "Dmel_CG8153, CG8153, DhR4, DhXPC, DmXPC, Dmel\CG8153, Mus 210, Mus210, XPC[DM]c, mus(2)201, mus(2)201G1, mus(2)201[GI], mus201[G1], mus210, mus212, Xpc " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011432 3669 ISG20 http://www.ncbi.nlm.nih.gov/gene/?term=3669 "CD25, HEM45 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011433 3669 ISG20 http://www.ncbi.nlm.nih.gov/gene/?term=3669 "CD25, HEM45 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011434 366 AQP9 http://www.ncbi.nlm.nih.gov/gene/?term=366 "AQP-9, HsT17287, SSC1, T17287 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00011435 3671 ISLR http://www.ncbi.nlm.nih.gov/gene/?term=3671 HsT17563 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011436 36743 tun http://www.ncbi.nlm.nih.gov/gene/?term=36743 "Dmel_CG8253, BcDNA:LD38553, CG8253, Dmel\CG8253, Ntaq1 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011437 3674 ITGA2B http://www.ncbi.nlm.nih.gov/gene/?term=3674 "GT, GTA, CD41, GP2B, HPA3, CD41B, GPIIb, BDPLT2, BDPLT16, PPP1R93 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00011438 3674 ITGA2B http://www.ncbi.nlm.nih.gov/gene/?term=3674 "BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00011439 3675 ITGA3 http://www.ncbi.nlm.nih.gov/gene/?term=3675 "CD49C, FRP-2, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011440 3675 ITGA3 http://www.ncbi.nlm.nih.gov/gene/?term=3675 "CD49C, FRP-2, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011441 36769 casp http://www.ncbi.nlm.nih.gov/gene/?term=36769 "Dmel_CG8400, CASP, CG8400, Dmel\CG8400 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011442 36769 casp http://www.ncbi.nlm.nih.gov/gene/?term=36769 "Dmel_CG8400, CASP, CG8400, Dmel\CG8400 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011443 36772 CG8405 http://www.ncbi.nlm.nih.gov/gene/?term=36772 Dmel_ Dmel\CG8405 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011444 36772 CG8405 http://www.ncbi.nlm.nih.gov/gene/?term=36772 Dmel_ Dmel\CG8405 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011445 36774 CG8414 http://www.ncbi.nlm.nih.gov/gene/?term=36774 Dmel_ Dmel\CG8414 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011446 36775 Rho1 http://www.ncbi.nlm.nih.gov/gene/?term=36775 "Dmel_CG8416, 19549712, 8416, AAF01186, CG8416, D- DRho, DRho1, DRhoA, Dm Rho1, DmRHO-A, Dmel\CG8416, Drho1, DrhoA, E3.10/J3.8, P48148, RHO, RHO1, Rho, Rho A, Rho GTPase, Rho kinase, RhoA, RhoN19, dRho1, dRhoA, dnRho, l(2)52Fa, l(2)k02107b, n(2)k07236, rho, rho1, rhoA " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011447 36776 Ric http://www.ncbi.nlm.nih.gov/gene/?term=36776 "Dmel_CG8418, 17137290, CG8418, D-Ric, Dmel\CG8418, Q7JMZ0, RIC, Roc " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011448 3678 ITGA5 http://www.ncbi.nlm.nih.gov/gene/?term=3678 "FNRA, CD49e, VLA-5, VLA5A " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00011449 3678 ITGA5 http://www.ncbi.nlm.nih.gov/gene/?term=3678 "CD49e, FNRA, VLA-5, VLA5A " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00011450 36797 mrj http://www.ncbi.nlm.nih.gov/gene/?term=36797 "Dmel_CG8448, CG8448, Dmel\CG8448, MRJ, dMRJ, d " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011451 36797 mrj http://www.ncbi.nlm.nih.gov/gene/?term=36797 "Dmel_CG8448, CG8448, Dmel\CG8448, MRJ, dMRJ, d " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011452 3679 ITGA7 http://www.ncbi.nlm.nih.gov/gene/?term=3679 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011453 367 AR http://www.ncbi.nlm.nih.gov/gene/?term=367 "AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011454 36810 Khc http://www.ncbi.nlm.nih.gov/gene/?term=36810 "Dmel_CG7765, CG7765, DK, DKH, DmK, DmKHC, Dmel\CG7765, Dmkin, KHC, KIF 5A, KIF5B, KIN, Kin, Kin-1, Kinesin-1, khc, kin, kinesin, kinesin-1, l(2)W12, l(2)k13219, l(2)k13314, l(2R)W12, pgs " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011455 36820 CG7747 http://www.ncbi.nlm.nih.gov/gene/?term=36820 "Dmel_ CYC4, Dmel\CG7747 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011456 3682 ITGAE http://www.ncbi.nlm.nih.gov/gene/?term=3682 "CD103, HUMINAE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011457 3682 ITGAE http://www.ncbi.nlm.nih.gov/gene/?term=3682 "CD103, HUMINAE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011458 3683 ITGAL http://www.ncbi.nlm.nih.gov/gene/?term=3683 "CD11A, LFA-1, LFA1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011459 3684 ITGAM http://www.ncbi.nlm.nih.gov/gene/?term=3684 "CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011460 36858 CG8303 http://www.ncbi.nlm.nih.gov/gene/?term=36858 Dmel_ Dmel\CG8303 mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011461 3685 ITGAV http://www.ncbi.nlm.nih.gov/gene/?term=3685 "CD51, MSK8, VNRA, VTNR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011462 3685 ITGAV http://www.ncbi.nlm.nih.gov/gene/?term=3685 "CD51, MSK8, VNRA, VTNR " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011463 36868 CG5210 http://www.ncbi.nlm.nih.gov/gene/?term=36868 "Dmel_ Chit, Chit13, Cht13, DS47, DmDS47, Dmel\CG5210, chit, ds47 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011464 3687 ITGAX http://www.ncbi.nlm.nih.gov/gene/?term=3687 "CD11C, SLEB6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011465 3687 ITGAX http://www.ncbi.nlm.nih.gov/gene/?term=3687 "CD11C, SLEB6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011466 3688 ITGB1 http://www.ncbi.nlm.nih.gov/gene/?term=3688 "CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011467 3688 ITGB1 http://www.ncbi.nlm.nih.gov/gene/?term=3688 "CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011468 3688 ITGB1 http://www.ncbi.nlm.nih.gov/gene/?term=3688 "CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011469 3688 ITGB1 http://www.ncbi.nlm.nih.gov/gene/?term=3688 "CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB " mRNA Homo sapiens 22679391 Endoplasmic reticulum U2OS cell RT-PCR "Endogenous mRNAs remain associated with the ER independently of ribosomes and translation.(A) The levels of Sec61a and bactin transcripts isolated from unbound (i.e., non-ER) cytoplasmic and ER fractions from either cycloheximide treated (¡°Control¡±) or puromycin treated EDTA extracted ( Puromycin+EDTA ) U2OS cells were assessed by quantitative RT-PCR analysis. Each bar represents the levels of the specified transcript normalized to 28S rRNA levels, standardized to the level of mRNA in the control sample, and averaged between three independent experiments. Error bars represent the standard error of the mean. Note that 28S rRNA was used as the large ribosomal subunit is known to associate to the ER even after puromycin treatment [35] and that ribosomes are equally distributed in cytoplasmic and ER (see Figure 1F). The level of Sec61a mRNA was normalized to the ER fraction from control cells, while the b-actin mRNA was normalized to the cytoplasmic fraction from control cells. (B) The levels of several transcripts in the ER fraction were analyzed as in (A). Measured transcripts include those encoding ER luminal proteins (BiP, Calreticulin), ER membrane proteins (Inositol-3-phosphate Receptor (IP3 Receptor), Sec61a, Trapa, and Fatty Acid Desaturase 3 (FADS3)), a Golgi protein (Mannosidase 2A (Man2A)), plasma membrane proteins (Integrin b1, and Transferrin Receptor (Tf Receptor)), and a secreted protein (Interleukin 7 (IL7)). All measurements were standardized to the level of mRNA in the ER fraction from control cells. " RLID00011470 3689 ITGB2 http://www.ncbi.nlm.nih.gov/gene/?term=3689 "CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011471 3691 ITGB4 http://www.ncbi.nlm.nih.gov/gene/?term=3691 CD104 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011472 3691 ITGB4 http://www.ncbi.nlm.nih.gov/gene/?term=3691 "CD104, GP150 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011473 36922 CG6967 http://www.ncbi.nlm.nih.gov/gene/?term=36922 "Dmel_ CT21565, Dmel\CG6967 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011474 3692 EIF6 http://www.ncbi.nlm.nih.gov/gene/?term=3692 "CAB, EIF3A, ITGB4BP, b(2)gcn, eIF-6, p27(BBP), p27BBP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011475 3693 ITGB5 http://www.ncbi.nlm.nih.gov/gene/?term=3693 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011476 3693 ITGB5 http://www.ncbi.nlm.nih.gov/gene/?term=3693 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011477 3697 ITIH1 http://www.ncbi.nlm.nih.gov/gene/?term=3697 "H1P, IATIH, IGHEP1, ITI-HC1, ITIH, SHAP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011478 369 ARAF http://www.ncbi.nlm.nih.gov/gene/?term=369 "A-RAF, ARAF1, PKS2, RAFA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011479 369 ARAF http://www.ncbi.nlm.nih.gov/gene/?term=369 "A-RAF1, PKS2, RAFA1, ARAF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011480 36 ACADSB http://www.ncbi.nlm.nih.gov/gene/?term=36 "2-MEBCAD, ACAD7, SBCAD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011481 37000 CG10936 http://www.ncbi.nlm.nih.gov/gene/?term=37000 Dmel_ Dmel\CG10936 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011482 37007 Sema-1b http://www.ncbi.nlm.nih.gov/gene/?term=37007 "Dmel_CG6446, BcDNA:GH03186, CG6446, D-semaIII, Dmel\CG6446, Sema 1b, Sema III, Sema1b, sema-III, sema1b " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011483 3700 ITIH4 http://www.ncbi.nlm.nih.gov/gene/?term=3700 "GP120, H4P, IHRP, ITI-HC4, ITIHL1, PK-120, PK120 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011484 37029 OstDelta http://www.ncbi.nlm.nih.gov/gene/?term=37029 "Dmel_CG6370, CG6370, Dmel\CG6370, OST " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011485 37039 olf186-M http://www.ncbi.nlm.nih.gov/gene/?term=37039 "Dmel_CG14489, CG14489, Dmel\CG14489 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011486 3703 STT3A http://www.ncbi.nlm.nih.gov/gene/?term=3703 "ITM1, STT3-A, TMC " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011487 3703 STT3A http://www.ncbi.nlm.nih.gov/gene/?term=3703 "ITM1, STT3-A, TMC " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011488 37043 Mapmodulin http://www.ncbi.nlm.nih.gov/gene/?term=37043 "Dmel_CG5784, CG5784, CT18148, CT42180, Dmel\CG5784, anon-EST:fe3A2 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011489 37043 Mapmodulin http://www.ncbi.nlm.nih.gov/gene/?term=37043 "Dmel_CG5784, CG5784, CT18148, CT42180, Dmel\CG5784, anon-EST:fe3A2 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011490 3704 ITPA http://www.ncbi.nlm.nih.gov/gene/?term=3704 "C20orf37, EIEE35, HLC14-06-P, My049, dJ794I6.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011491 3704 ITPA http://www.ncbi.nlm.nih.gov/gene/?term=3704 "C20orf37, EIEE35, HLC14-06-P, My049, dJ794I6.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011492 3704 ITPA http://www.ncbi.nlm.nih.gov/gene/?term=3704 "C20orf37, EIEE35, HLC14-06-P, My049, dJ794I6.3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011493 3705 ITPK1 http://www.ncbi.nlm.nih.gov/gene/?term=3705 ITRPK1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011494 37069 Pcl http://www.ncbi.nlm.nih.gov/gene/?term=37069 "Dmel_CG5109, CG5109, Dmel\CG5109, PCL, l(2)s1859, pcl " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00011495 37070 pAbp http://www.ncbi.nlm.nih.gov/gene/?term=37070 "Dmel_CG5119, BcDNA:LD24412, CG16803, CG5119, Dmel\CG5119, PABP, PABP55B, PABPC1, PAbp, Pabp, anon-EST:Posey247, anon-EST:Posey249, anon-EST:fe2E5, dPABP, duo, l(2)SH1908, l(2)SH2 1908, l(2)k10109, pAB, pABP, pabp " mRNA Drosophila melanogaster 17923096 Posterior Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011496 37089 fj http://www.ncbi.nlm.nih.gov/gene/?term=37089 "Dmel_CG10917, CG10917, Dmel\CG10917, Fj " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011497 3708 ITPR1 http://www.ncbi.nlm.nih.gov/gene/?term=3708 "ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011498 3708 ITPR1 http://www.ncbi.nlm.nih.gov/gene/?term=3708 "ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29 " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00011499 37098 CG14505 http://www.ncbi.nlm.nih.gov/gene/?term=37098 Dmel_ Dmel\CG14505 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011500 3709 ITPR2 http://www.ncbi.nlm.nih.gov/gene/?term=3709 "ANHD, CFAP48, INSP3R2, IP3R2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011501 3709 ITPR2 http://www.ncbi.nlm.nih.gov/gene/?term=3709 "ANHD, CFAP48, INSP3R2, IP3R2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011502 3709 ITPR2 http://www.ncbi.nlm.nih.gov/gene/?term=3709 "ANHD, CFAP48, INSP3R2, IP3R2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011503 3710 ITPR3 http://www.ncbi.nlm.nih.gov/gene/?term=3710 "IP3R, IP3R3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011504 3710 ITPR3 http://www.ncbi.nlm.nih.gov/gene/?term=3710 "IP3R, IP3R3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011505 3710 ITPR3 http://www.ncbi.nlm.nih.gov/gene/?term=3710 "IP3R, IP3R3 " mRNA Homo sapiens 22679391 Endoplasmic reticulum U2OS cell RT-PCR "Figure 3B: The levels of several transcripts in the ER fraction were analyzed as in (A). Measured transcripts include those encoding ER luminal proteins (BiP, Calreticulin), ER membrane proteins (Inositol-3-phosphate Receptor (IP3 Receptor), Sec61α, Trapα, and Fatty Acid Desaturase 3 (FADS3)), a Golgi protein (Mannosidase 2A (Man2A)), plasma membrane proteins (Integrin β1, and Transferrin Receptor (Tf Receptor)), and a secreted protein (Interleukin 7 (IL7)). All measurements were standardized to the level of mRNA in the ER fraction from control cells. Data are collected from Figure 3B. " RLID00011506 37119 CG30118 http://www.ncbi.nlm.nih.gov/gene/?term=37119 "Dmel_ CG16859, CG5544, Dmel\CG30118 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011507 37119 CG30118 http://www.ncbi.nlm.nih.gov/gene/?term=37119 "Dmel_ CG16859, CG5544, Dmel\CG30118 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011508 37123 Prp19 http://www.ncbi.nlm.nih.gov/gene/?term=37123 "Dmel_CG5519, BcDNA:LD02793, CG5519, Dmel\CG5519, EC2-11, GPB, Gbp, PRP19, l(2)07838, prp19 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011509 3712 IVD http://www.ncbi.nlm.nih.gov/gene/?term=3712 ACAD2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011510 3712 IVD http://www.ncbi.nlm.nih.gov/gene/?term=3712 ACAD2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011511 37131 Pepck http://www.ncbi.nlm.nih.gov/gene/?term=37131 "Dmel_CG17725, 143299_at, CG10924, CG17725, Dmel\CG17725, Dromel_CG17725_FBtr0086701_pepck_mORF, PEPCK, dPEPCK, pepck " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011512 3714 JAG2 http://www.ncbi.nlm.nih.gov/gene/?term=3714 "HJ2, SER2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011513 37156 Vps51 http://www.ncbi.nlm.nih.gov/gene/?term=37156 "Dmel_CG15087, CG15087, Dmel\CG15087 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011514 37164 Jabba http://www.ncbi.nlm.nih.gov/gene/?term=37164 "Dmel_CG42351, 141242_at, BP1008, CG1509, CG15092, CG34020, CG42351, Dmel\CG42351, Dmel_CG15092, Dmel_CG34020, anon-WO0118547.167 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011515 37164 Jabba http://www.ncbi.nlm.nih.gov/gene/?term=37164 "Dmel_CG42351, 141242_at, BP1008, CG1509, CG15092, CG34020, CG42351, Dmel\CG42351, Dmel_CG15092, Dmel_CG34020, anon-WO0118547.167 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011516 37166 CG15093 http://www.ncbi.nlm.nih.gov/gene/?term=37166 "Dmel_ CG 15093, CT34968, Dmel\CG15093 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011517 3716 JAK1 http://www.ncbi.nlm.nih.gov/gene/?term=3716 "JAK1A, JAK1B, JTK3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011518 3716 JAK1 http://www.ncbi.nlm.nih.gov/gene/?term=3716 "JAK1AB, JTK3, JAK1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011519 3716 JAK1 http://www.ncbi.nlm.nih.gov/gene/?term=3716 "JAK1AB, JTK3, JAK1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011520 3718 JAK3 http://www.ncbi.nlm.nih.gov/gene/?term=3718 "JAK-3_HUMAN, JAKL, L-JAK, LJAK, JAK3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011521 3718 JAK3 http://www.ncbi.nlm.nih.gov/gene/?term=3718 "JAK-3_HUMAN, JAKL, L-JAK, LJAK, JAK3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011522 3720 JARID2 http://www.ncbi.nlm.nih.gov/gene/?term=3720 JMJ mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011523 37223 CG9416 http://www.ncbi.nlm.nih.gov/gene/?term=37223 "Dmel_CG9416-PA, Dmel\CG9416 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011524 37230 hts http://www.ncbi.nlm.nih.gov/gene/?term=37230 "Dmel_CG43443, 1B1, ADD-87, Add, Add-hts, Adducin, CG34197, CG43443, CG9325, Dmel\CG43443, Dmel_CG34197, Dmel_CG9325, EST D, HTS, HTS-R1, HTS-RC, HTS_DROME, Hts, Hts-RC, HtsF, HtsRC, Ovhts, Ovhts-RC, add, add-like, adducin, anon-EST:Posey9RC, l(2)00634, l(2)01103, l(2)k06121, l(2)k14523, hts " mRNA Drosophila melanogaster 19217894 Cell cortex Oocyte In situ hybridization "The htsN4 mRNA is positioned at the anterior of the oocyte, where it is largely restricted to the junctions of anterior and lateral cortex. " RLID00011525 3725 JUN http://www.ncbi.nlm.nih.gov/gene/?term=3725 "AP-1, AP1, c-Jun " mRNA Homo sapiens 24019514 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmid containing either full-length ALPP, t-ftz, AP1, AP2, AP3, AP4, or AP5 and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (C or Ctrl) or HHT (H) for 30 min and then extracted with digitonin. Cells were then fixed, stained for mRNAs using specific FISH probes (ftz probe was used to detect AP1-5), and imaged. Figure 3A, quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 3. " RLID00011526 3725 JUN http://www.ncbi.nlm.nih.gov/gene/?term=3725 "AP-1, AP1, c-Jun " mRNA Homo sapiens 24019514 Nucleus COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmid containing either full-length ALPP, t-ftz, AP1, AP2, AP3, AP4, or AP5 and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (C or Ctrl) or HHT (H) for 30 min and then extracted with digitonin. Cells were then fixed, stained for mRNAs using specific FISH probes (ftz probe was used to detect AP1-5), and imaged. Figure 3A, quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 3. " RLID00011527 3726 JUNB http://www.ncbi.nlm.nih.gov/gene/?term=3726 AP-1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011528 3726 JUNB http://www.ncbi.nlm.nih.gov/gene/?term=3726 AP-1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011529 3726 JUNB http://www.ncbi.nlm.nih.gov/gene/?term=3726 AP-1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011530 3727 JUND http://www.ncbi.nlm.nih.gov/gene/?term=3727 AP-1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011531 3727 JUND http://www.ncbi.nlm.nih.gov/gene/?term=3727 AP-1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011532 3727 JUND http://www.ncbi.nlm.nih.gov/gene/?term=3727 AP-1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011533 3728 JUP http://www.ncbi.nlm.nih.gov/gene/?term=3728 "ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011534 3728 JUP http://www.ncbi.nlm.nih.gov/gene/?term=3728 "ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011535 37290 PCNA http://www.ncbi.nlm.nih.gov/gene/?term=37290 "Dmel_CG9193, 53/13, CG9193, DmPCNA, Dmel\CG9193, MUS209, Mus209/mus209, Pcna, dPCNA, l(2)02448, l(2)56F, l(2)56Fa, l(2)s1534, mus 209, mus209, pcna, PCNA " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011536 37290 PCNA http://www.ncbi.nlm.nih.gov/gene/?term=37290 "Dmel_CG9193, 53/13, CG9193, DmPCNA, Dmel\CG9193, MUS209, Mus209/mus209, Pcna, dPCNA, l(2)02448, l(2)56F, l(2)56Fa, l(2)s1534, mus 209, mus209, pcna, PCNA " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011537 37294 CG10444 http://www.ncbi.nlm.nih.gov/gene/?term=37294 "Dmel_ Dmel\CG10444, dSLC5A3 " mRNA Drosophila melanogaster 25838129 Perinuclear Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011538 372 ARCN1 http://www.ncbi.nlm.nih.gov/gene/?term=372 COPD mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011539 372 ARCN1 http://www.ncbi.nlm.nih.gov/gene/?term=372 COPD mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011540 372 ARCN1 http://www.ncbi.nlm.nih.gov/gene/?term=372 COPD mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011541 372 ARCN1 http://www.ncbi.nlm.nih.gov/gene/?term=372 COPD mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011542 372 ARCN1 http://www.ncbi.nlm.nih.gov/gene/?term=372 COPD mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011543 37301 CG11200 http://www.ncbi.nlm.nih.gov/gene/?term=37301 "Dmel_CG11200, Dmel\CG11200 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011544 373074 dnd1 http://www.ncbi.nlm.nih.gov/gene/?term=373074 "cb736, dnd, wu:fi22d10, zgc:111864 " mRNA Danio rerio 16457796 Germ plasm Embryo Fluorescence in situ hybridization "Fig. 1. Endogenous patterns of RNA localization of dnd, nos1, vas, and dazl RNAs during the first cell cycle. Animal views of embryos fixed at progressively older stages of development (A-D: 15 min p.f.; E-H: 30 min. p.f.; I-L: 45 min p.f.) and labeled using FISH to detect germ plasm RNAs (dnd (A, E, I); nos1 (B, F, J); vas(C,G, K); dazl (D, H, L). (A-D) Immediately after fertilization, dnd, nos1, and vas RNA aggregates can be observed as a band at the animal pole, while dazl RNA aggregates are not initially present in the animal pole. (E-H) During the initiation of furrow formation, RNA aggregates fordnd, nos1, and vas begin to be recruited as a rod at the forming furrow (arrows in E-G). At this stage, dazl RNA is not yet detectable at the furrows (H). (I-L) As the furrow matures, there is an increase in the amount of dnd, nos1, and vasRNAs recruited at the furrow, and dazlRNA becomes detectable at the furrow (arrows in I-L). Scale bar in panel (L) represents 100 μmThus, although all four RNAs are recruited to the forming furrow, RNAs for dnd, nos1, and vas are already present in the animal pole in the freshly laid egg, while dazlRNA arrives to the animal pole from the vegetal region at a later stage. Based on their different times of appearance at the animal region, we refer to the dnd, nos1, and vas RNAs as the early animal germ plasm RNAs, while dazl is also referred to as a vegetally localized germ plasm RNA. " RLID00011545 3730 ANOS1 http://www.ncbi.nlm.nih.gov/gene/?term=3730 "ADMLX, HH1, HHA, KAL, KAL1, KALIG-1, KMS, WFDC19 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011546 373156 GSTK1 http://www.ncbi.nlm.nih.gov/gene/?term=373156 "GST, GST 13-13, GST13, GST13-13, GSTK1-1, hGSTK1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011547 373156 GSTK1 http://www.ncbi.nlm.nih.gov/gene/?term=373156 "GST, GST 13-13, GST13, GST13-13-1, hGSTK1, GSTK1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011548 3732 CD82 http://www.ncbi.nlm.nih.gov/gene/?term=3732 "4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011549 3732 CD82 http://www.ncbi.nlm.nih.gov/gene/?term=3732 "4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011550 37355 insc http://www.ncbi.nlm.nih.gov/gene/?term=37355 "Dmel_CG11312, 25/17, CG11312, Dmel\CG11312, INSC, Ins, Insc, fam, l(2)05475, l(2)k12405, nem " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011551 3735 KARS http://www.ncbi.nlm.nih.gov/gene/?term=3735 "CMTRIB, DFNB89, KARS1, KARS2, KRS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011552 3735 KARS http://www.ncbi.nlm.nih.gov/gene/?term=3735 "CMTRIB, DFNB891, KARS2, KRS, KARS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011553 37387 cpa http://www.ncbi.nlm.nih.gov/gene/?term=37387 "Dmel_CG10540, CG10540, Cpa, Dmel\CG10540, miro, scrd " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011554 373 TRIM23 http://www.ncbi.nlm.nih.gov/gene/?term=373 "ARD1, ARFD1, RNF46 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011555 373 TRIM23 http://www.ncbi.nlm.nih.gov/gene/?term=373 "ARD1, ARFD1, RNF46 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011556 374040 DIAPH1 http://www.ncbi.nlm.nih.gov/gene/?term=374040 DIAPH2 mRNA Gallus gallus 23840831 Endoplasmic reticulum Fibroblast Fluorescence in situ hybridization "Here, we provide evidence to demonstrate that the 5â€?cap-mediated immediate translation of DIAPH1 mRNA upon exiting nucleus is required for localizing the mRNA in the perinuclear ER compartment. " RLID00011557 374040 DIAPH1 http://www.ncbi.nlm.nih.gov/gene/?term=374040 DIAPH2 mRNA Gallus gallus 23840831 Nucleus Fibroblast Fluorescence in situ hybridization "Here, we provide evidence to demonstrate that the 5â€?cap-mediated immediate translation of DIAPH1 mRNA upon exiting nucleus is required for localizing the mRNA in the perinuclear ER compartment. " RLID00011558 374197 ACTR3 http://www.ncbi.nlm.nih.gov/gene/?term=374197 mRNA Gallus gallus 15923655 Cell leading edge Fibroblast Fluorescence in situ hybridization "The localization of the Arp2/3 complex mRNAs is dependent on both actin filaments and microtubules, because disruption of either cytoskeletal system (with cytochalasin D and colchicine, respectively) inhibited the localization of all seven subunit mRNAs. To address these questions, double detection of two types of mRNAs simultaneously in the same cells was performed by sequential FISH-TSA. As shown in Fig. 5A-C, Arp3 mRNA appears not to be precisely colocalized with β-actin mRNA, although they both concentrate together in the protrusions. In addition, the Arp2 and Arp3 mRNAs also do not colocalize, although they are both concentrated together in the protrusions (Fig. 5D-F). " RLID00011559 374197 ACTR3 http://www.ncbi.nlm.nih.gov/gene/?term=374197 mRNA Gallus gallus 15923655 Cell leading edge Fibroblast Fluorescence in situ hybridization "Figure 7: Quantification of Arp2/3-complex mRNA localization in fibroblasts. The proportion of the cells with localized mRNA was quantified by counting all the cells in randomly selected fields in the fluorescence microscope. 300-500 cells were scored for each mRNA from three independent experiments. Error bars indicate s.e.m. **, statistically significant (P<0.01) differences from control basal level of poly-A RNA. " RLID00011560 37422 ASPP http://www.ncbi.nlm.nih.gov/gene/?term=37422 "Dmel_CG18375, CG18375, Dmel\CG18375, dASPP " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011561 374286 CDRT1 http://www.ncbi.nlm.nih.gov/gene/?term=374286 "C170RF1, C17ORF1, C17ORF1A, FBXW10B, FBXW10P1, HREP, SM25H2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011562 374286 CDRT1 http://www.ncbi.nlm.nih.gov/gene/?term=374286 "C170RF1, C17ORF1, C17ORF1A, FBXW10B, FBXW10P1, HREP, SM25H2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011563 374354 NHLRC2 http://www.ncbi.nlm.nih.gov/gene/?term=374354 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011564 37437 CG30394 http://www.ncbi.nlm.nih.gov/gene/?term=37437 "Dmel_ CG10500, CG15670, Dmel\CG30394, anon-WO0172774.187, anon-WO0172774.188 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011565 374383 NCR3LG1 http://www.ncbi.nlm.nih.gov/gene/?term=374383 "B7-H6, B7H6, DKFZp686O24166 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011566 374393 FAM111B http://www.ncbi.nlm.nih.gov/gene/?term=374393 "CANP, POIKTMP " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011567 374395 TMEM179B http://www.ncbi.nlm.nih.gov/gene/?term=374395 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011568 37447 Sdc http://www.ncbi.nlm.nih.gov/gene/?term=37447 "Dmel_CG10497, CG10497, CT27296, Dmel\CG10497, Dsyn, Syd, Syn, dSdc, l(2)10608, sdc, syd, syn " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011569 37447 Sdc http://www.ncbi.nlm.nih.gov/gene/?term=37447 "Dmel_CG10497, CG10497, CT27296, Dmel\CG10497, Dsyn, Syd, Syn, dSdc, l(2)10608, sdc, syd, syn " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011570 374500 THSD1P1 http://www.ncbi.nlm.nih.gov/gene/?term=374500 THSD1P lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011571 37451 MESK2 http://www.ncbi.nlm.nih.gov/gene/?term=37451 "Dmel_CG15669, BcDNA:GH12032, BcDNA:LD27504, BcDNA:RH10174, CG15668, CG15669, Dmel\CG15669, Mesk2, l(2)01467, mesk2 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011572 37454 CG30283 http://www.ncbi.nlm.nih.gov/gene/?term=37454 "Dmel_ CG10450, Dmel\CG30283, SP37, SPH37 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011573 37458 CG10433 http://www.ncbi.nlm.nih.gov/gene/?term=37458 Dmel_ Dmel\CG10433 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011574 374650 GOLGA6L5P http://www.ncbi.nlm.nih.gov/gene/?term=374650 "GOLGA6L5, GOLGA6L8 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011575 374655 ZNF710 http://www.ncbi.nlm.nih.gov/gene/?term=374655 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011576 374659 HDDC3 http://www.ncbi.nlm.nih.gov/gene/?term=374659 "(ppGpp)ase, MESH1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011577 374666 WASH3P http://www.ncbi.nlm.nih.gov/gene/?term=374666 FAM39DP lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011578 37471 NC2alpha http://www.ncbi.nlm.nih.gov/gene/?term=37471 "Dmel_CG10318, CG10318, Dmel\CG10318, Drap1, NC2, Nc2alpha, dDrap, dDrap1, dDrap1/dNC2a, dNC2 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00011579 374868 ATP9B http://www.ncbi.nlm.nih.gov/gene/?term=374868 "ATPASEP, ATPIIB, HUSSY-20, NEO1L, hMMR1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011580 374868 ATP9B http://www.ncbi.nlm.nih.gov/gene/?term=374868 "ATPASEP, ATPIIB, HUSSY-20, NEO1L, hMMR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011581 374872 C19orf35 http://www.ncbi.nlm.nih.gov/gene/?term=374872 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011582 374872 C19orf35 http://www.ncbi.nlm.nih.gov/gene/?term=374872 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011583 374882 TMEM205 http://www.ncbi.nlm.nih.gov/gene/?term=374882 UNQ501 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011584 374882 TMEM205 http://www.ncbi.nlm.nih.gov/gene/?term=374882 UNQ501 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011585 374920 C19orf68 http://www.ncbi.nlm.nih.gov/gene/?term=374920 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011586 374969 SVBP http://www.ncbi.nlm.nih.gov/gene/?term=374969 CCDC23 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011587 374 AREG http://www.ncbi.nlm.nih.gov/gene/?term=374 "AR, AREGB, CRDGF, SDGF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011588 375035 SFT2D2 http://www.ncbi.nlm.nih.gov/gene/?term=375035 "UNQ512, dJ747L4.C1.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011589 375056 MIA3 http://www.ncbi.nlm.nih.gov/gene/?term=375056 "ARNT, D320, TANGO, TANGO1, UNQ6077 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011590 375056 MIA3 http://www.ncbi.nlm.nih.gov/gene/?term=375056 "ARNT, D320, TANGO, TANGO1, UNQ6077 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011591 375061 FAM89A http://www.ncbi.nlm.nih.gov/gene/?term=375061 C1orf153 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011592 375061 FAM89A http://www.ncbi.nlm.nih.gov/gene/?term=375061 C1orf153 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011593 37511 Snp http://www.ncbi.nlm.nih.gov/gene/?term=37511 "Dmel_CG44248, CG11478, CG30327, CG42257, CG44248, CG6393, Dmel\CG44248, Dmel_CG30327, Dmel_CG42257, Dmel_CG6393 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011594 37521 Vrp1 http://www.ncbi.nlm.nih.gov/gene/?term=37521 "Dmel_CG13503, CG13503, D-WIP, Dm_Vrp1, Dmel\CG13503, WIP, dWIP, sltr, solas, vrp1, wip " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011595 375248 ANKRD36 http://www.ncbi.nlm.nih.gov/gene/?term=375248 UNQ2430 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011596 375287 RBM43 http://www.ncbi.nlm.nih.gov/gene/?term=375287 C2orf38 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011597 375287 RBM43 http://www.ncbi.nlm.nih.gov/gene/?term=375287 C2orf38 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011598 375295 LINC01116 http://www.ncbi.nlm.nih.gov/gene/?term=375295 lncRNA Homo sapiens 25630241 Cytoplasm Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00011599 375295 LINC01116 http://www.ncbi.nlm.nih.gov/gene/?term=375295 lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00011600 375346 TMEM110 http://www.ncbi.nlm.nih.gov/gene/?term=375346 STIMATE mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011601 37534 CG11275 http://www.ncbi.nlm.nih.gov/gene/?term=37534 "Dmel_ Dmel\CG11275, i188 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011602 37534 CG11275 http://www.ncbi.nlm.nih.gov/gene/?term=37534 "Dmel_ Dmel\CG11275, i188 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011603 37535 MED16 http://www.ncbi.nlm.nih.gov/gene/?term=37535 "Dmel_CG5465, CG5465, Dmel\CG5465, Med16, Sin4/TRAP95, Trap95, dTRAP95, med16 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011604 375449 MAST4 http://www.ncbi.nlm.nih.gov/gene/?term=375449 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011605 37547 CG5819 http://www.ncbi.nlm.nih.gov/gene/?term=37547 "Dmel_ 5819, CT18212, Dmel\CG5819, tartan/capricious-like " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011606 37549 Gp150 http://www.ncbi.nlm.nih.gov/gene/?term=37549 "Dmel_CG5820, CG5820, CT18251, Dmel\CG5820, GP150, anon-EST:fe2A1, gp150, l(2)52A, p150 " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011607 375513 GUSBP4 http://www.ncbi.nlm.nih.gov/gene/?term=375513 "C6orf216, GUSBL2, SMA3-L, SMAC3L " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011608 37556 CG13506 http://www.ncbi.nlm.nih.gov/gene/?term=37556 "Dmel_ 13506, CT32874, Dmel\CG13506 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011609 37557 babos http://www.ncbi.nlm.nih.gov/gene/?term=37557 "Dmel_CG3624, CG3624, CT12183, Dmel\CG3624 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011610 375593 TRIM73 http://www.ncbi.nlm.nih.gov/gene/?term=375593 TRIM50B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011611 375690 WASH5P http://www.ncbi.nlm.nih.gov/gene/?term=375690 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011612 375743 PTAR1 http://www.ncbi.nlm.nih.gov/gene/?term=375743 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011613 375743 PTAR1 http://www.ncbi.nlm.nih.gov/gene/?term=375743 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011614 375743 PTAR1 http://www.ncbi.nlm.nih.gov/gene/?term=375743 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011615 375748 ERCC6L2 http://www.ncbi.nlm.nih.gov/gene/?term=375748 "BMFS2, C9orf102, RAD26L, SR278 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011616 375757 SWI5 http://www.ncbi.nlm.nih.gov/gene/?term=375757 "C9orf119, SAE3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011617 37575 dnr1 http://www.ncbi.nlm.nih.gov/gene/?term=37575 "Dmel_CG12489, CG12489, DNR1, Dmel\CG12489, Dnr1 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011618 375790 AGRN http://www.ncbi.nlm.nih.gov/gene/?term=375790 "CMS8, CMSPPD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011619 375790 AGRN http://www.ncbi.nlm.nih.gov/gene/?term=375790 "CMS8, CMSPPD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011620 375791 CYSRT1 http://www.ncbi.nlm.nih.gov/gene/?term=375791 C9orf169 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011621 3757 KCNH2 http://www.ncbi.nlm.nih.gov/gene/?term=3757 "ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1, LQT2, SQT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011622 37588 CG3732 http://www.ncbi.nlm.nih.gov/gene/?term=37588 Dmel_ Dmel\CG3732 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011623 375 ARF1 http://www.ncbi.nlm.nih.gov/gene/?term=375 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011624 375 ARF1 http://www.ncbi.nlm.nih.gov/gene/?term=375 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011625 37601 RYBP http://www.ncbi.nlm.nih.gov/gene/?term=37601 "Dmel_CG12190, CG12190, Dmel\CG12190, dRYBP " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011626 376132 LRRC10 http://www.ncbi.nlm.nih.gov/gene/?term=376132 "HRLRRPA, LRRC10 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011627 376132 LRRC10 http://www.ncbi.nlm.nih.gov/gene/?term=376132 "HRLRRPA, LRRC10 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011628 37618 CycB http://www.ncbi.nlm.nih.gov/gene/?term=37618 "Dmel_CG3510, 2g, 3510, CG3510, CYC-B, CYCB, Cyc B, Cycb, DmcycB, Dmel\CG3510, chr2R:18312808..18312907, cyc B, cyc-B, cycB, cyclin B, cyclinB, mAbF2F4 " mRNA Danio rerio 11150242 Cytoplasm Oocyte In situ hybridization "To examine changes in localization of cyclin B mRNA during oogenesis, we performed in situ hybridization analysis in this study. In previtellogenic oocytes,cyclin B mRNA was uniformly distributed throughout the cytoplasm. " RLID00011629 37618 CycB http://www.ncbi.nlm.nih.gov/gene/?term=37618 "Dmel_CG3510, 2g, 3510, CG3510, CYC-B, CYCB, Cyc B, Cycb, DmcycB, Dmel\CG3510, chr2R:18312808..18312907, cyc B, cyc-B, cycB, cyclin B, cyclinB, mAbF2F4 " mRNA Drosophila melanogaster 15852043 Germ plasm Oocyte - "MRNAs can also become localized by passively diffusing through the cytoplasm until they are trapped by a localized anchor. Several transcripts, such as nanos, gcl (germ cell-less) and Cyclin B mRNAs, become enriched in the D. melanogaster pole plasm in this way " RLID00011630 37618 CycB http://www.ncbi.nlm.nih.gov/gene/?term=37618 "Dmel_CG3510, 2g, 3510, CG3510, CYC-B, CYCB, Cyc B, Cycb, DmcycB, Dmel\CG3510, chr2R:18312808..18312907, cyc B, cyc-B, cycB, cyclin B, cyclinB, mAbF2F4 " mRNA Drosophila melanogaster 26242323 Germ plasm Embryo Fluorescence in situ hybridization "Next we determined the distribution of the known germ plasm enriched mRNAs cycB, nos, pgc, gcl and oskar (osk) and one control mRNAccr4, which appears evenly distributed throughout the embryo4 (Fig. 2a,b,h). " RLID00011631 37618 CycB http://www.ncbi.nlm.nih.gov/gene/?term=37618 "Dmel_CG3510, 2g, 3510, CG3510, CYC-B, CYCB, Cyc B, Cycb, DmcycB, Dmel\CG3510, chr2R:18312808..18312907, cyc B, cyc-B, cycB, cyclin B, cyclinB, mAbF2F4 " mRNA Drosophila melanogaster 17923096 Mitotic spindle Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011632 37618 CycB http://www.ncbi.nlm.nih.gov/gene/?term=37618 "Dmel_CG3510, 2g, 3510, CG3510, CYC-B, CYCB, Cyc B, Cycb, DmcycB, Dmel\CG3510, chr2R:18312808..18312907, cyc B, cyc-B, cycB, cyclin B, cyclinB, mAbF2F4 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011633 37618 CycB http://www.ncbi.nlm.nih.gov/gene/?term=37618 "Dmel_CG3510, 2g, 3510, CG3510, CYC-B, CYCB, Cyc B, Cycb, DmcycB, Dmel\CG3510, chr2R:18312808..18312907, cyc B, cyc-B, cycB, cyclin B, cyclinB, mAbF2F4 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011634 376267 RAB15 http://www.ncbi.nlm.nih.gov/gene/?term=376267 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011635 3762 KCNJ5 http://www.ncbi.nlm.nih.gov/gene/?term=3762 "CIR, GIRK4, KATP1, KIR3.4, LQT13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011636 3762 KCNJ5 http://www.ncbi.nlm.nih.gov/gene/?term=3762 "CIR, GIRK4, KATP1, KIR3.4, LQT13 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011637 3762 KCNJ5 http://www.ncbi.nlm.nih.gov/gene/?term=3762 "CIR, GIRK4, KATP1, KIR3.4, LQT13 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011638 376497 SLC27A1 http://www.ncbi.nlm.nih.gov/gene/?term=376497 "ACSVL5, FATP, FATP-1, FATP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011639 3764 KCNJ8 http://www.ncbi.nlm.nih.gov/gene/?term=3764 "KIR6.1, uKATP-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011640 3766 KCNJ10 http://www.ncbi.nlm.nih.gov/gene/?term=3766 "BIRK-10, KCNJ13-PEN, KIR1.2, KIR4.1, SESAME " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011641 3766 KCNJ10 http://www.ncbi.nlm.nih.gov/gene/?term=3766 "BIRK-10, KCNJ13-PEN, KIR1.2, KIR4.1, SESAME " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011642 3767 KCNJ11 http://www.ncbi.nlm.nih.gov/gene/?term=3767 "BIR, HHF2, IKATP, KIR6.2, MODY13, PHHI, TNDM3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011643 3767 KCNJ11 http://www.ncbi.nlm.nih.gov/gene/?term=3767 "BIR, HHF2, IKATP, KIR6.2, MODY13, PHHI, TNDM3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011644 376844 SDC4P http://www.ncbi.nlm.nih.gov/gene/?term=376844 lncRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00011645 376844 SDC4P http://www.ncbi.nlm.nih.gov/gene/?term=376844 lncRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00011646 376940 ZC3H6 http://www.ncbi.nlm.nih.gov/gene/?term=376940 ZC3HDC6 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011647 376940 ZC3H6 http://www.ncbi.nlm.nih.gov/gene/?term=376940 ZC3HDC6 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011648 376940 ZC3H6 http://www.ncbi.nlm.nih.gov/gene/?term=376940 ZC3HDC6 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011649 37708 CG3520 http://www.ncbi.nlm.nih.gov/gene/?term=37708 Dmel_ Dmel\CG3520 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011650 3771727 tRNA:P:90Ca http://www.ncbi.nlm.nih.gov/gene/?term=3771727 "Dmel_CR31567, AE002708.trna51-ProTGG, CR31567, Dmel\CR31567, Pro, chr3R.trna57-ProTGG, tRNA:P:TGG:AE002708-e, tRNA:Pro, tRNA:pro:90Ca " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011944.html RLID00011651 3771731 tRNA:I:49Fc http://www.ncbi.nlm.nih.gov/gene/?term=3771731 "Dmel_CR30521, AE002787.trna38-IleAAT, CR30245, CR30521, Dmel\CR30521, chr2R.trna20-IleAAT, ile-c, tRNA:I:AAT:AE002787-d, tRNA:ile:49Fc, tRNA[Ile] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011883.html RLID00011652 3771739 tRNA:CR30208 http://www.ncbi.nlm.nih.gov/gene/?term=3771739 "Dmel_CR30208, AE002575.trna1-TrpCCA, CR30208, Dmel\CR30208, chr2R.trna45-TrpCCA, tRNA:W:CCA:AE002575-a " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050208.html RLID00011653 3771741 tRNA:CR30407 http://www.ncbi.nlm.nih.gov/gene/?term=3771741 "Dmel_CR30407, AE002575.trna11-GlyTCC, CR30205, CR30407, Dmel\CR30407, chr2R.trna55-GlyTCC, tRNA:G:58AB, tRNA:G:TCC:AE002575-b, tRNA:gly:58AB, tRNA[Gly][[GGA]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050407.html RLID00011654 3771747 tRNA:R:12Ed http://www.ncbi.nlm.nih.gov/gene/?term=3771747 "Dmel_CR32617, AE002593.trna7-ArgTCG, CR32617, Dmel\CR32617, chrX.trna11-ArgTCG, tRNA-Arg, tRNA:R1, tRNA:R:TCG:AE002593-e, tRNA:arg1, tRNA:arg12Ed, tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011951.html RLID00011655 3771757 snoRNA:Psi28S-3327c http://www.ncbi.nlm.nih.gov/gene/?term=3771757 "Dmel_CR33753, CR33753, Dm-586, Dmel\CR33753, Psi28S-3327c, chr3L:13017350..13017456, psi28S-3327c, pug28S-3327, snoR586, snoRNA:586 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086601.html RLID00011656 3771761 tRNA:R2:84Fe http://www.ncbi.nlm.nih.gov/gene/?term=3771761 "Dmel_CR31584, AE002708.trna66-ArgACG, CR31584, Dmel\CR31584, chr3R.trna72-ArgACG, tRNA:R1, tRNA:R:ACG:AE002708-e, tRNA:arg1, tRNA:arg2:84Fe, tRNA[Arg][[2]], tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011963.html RLID00011657 3771766 tRNA:CR30249 http://www.ncbi.nlm.nih.gov/gene/?term=3771766 "Dmel_CR30249, AE002787.trna21-HisGTG, CR30249, Dmel\CR30249, chr2R.trna80-HisGTG, tRNA:H:GTG:AE002787-d, tRNA[His] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050249.html RLID00011658 3771767 tRNA:CR30239 http://www.ncbi.nlm.nih.gov/gene/?term=3771767 "Dmel_CR30239, CR30239, Dmel\CR30239, chr2R.trna25-GluCTC, tRNA:E4:53A, tRNA:Glu, tRNA:glu4:53A " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050239.html RLID00011659 3771768 snoRNA:Psi28S-2149 http://www.ncbi.nlm.nih.gov/gene/?term=3771768 "Dmel_CR33776, CR33776, Dm-143, Dmel\CR33776, Psi 28S-2149(SnoR143), Psi28S-2149, psi28S-2149, snoR143, snoRNA:143 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086664.html RLID00011660 3771769 tRNA:CR30199 http://www.ncbi.nlm.nih.gov/gene/?term=3771769 "Dmel_CR30199, AE002575.trna7-AlaCGC, CR30199, Dmel\CR30199, chr2R.trna51-AlaCGC, tRNA:A:CGC:AE002575-b, tRNA[[Ala]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050199.html RLID00011661 3771775 tRNA:K2:42Eb http://www.ncbi.nlm.nih.gov/gene/?term=3771775 "Dmel_CR30301, AE002778.trna3-LysCTT, CR30301, Dmel\CR30301, chr2R.trna90-LysCTT, tRNA:K2, tRNA:K:CTT:AE002778-c, tRNA:lys2:42Eb, tRNA[Lys][[2]], tRNAlys " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011893.html RLID00011662 3771776 tRNA:M3:46A http://www.ncbi.nlm.nih.gov/gene/?term=3771776 "Dmel_CR30003, AE002787.trna31-MetCAT, CR30003, CR30262, Dmel\CR30003, chr2R.trna13-MetCAT, tRNA:M:CAT:AE002787-c, tRNA:met3:46A, tRNA:met:46A, tRNA[Met-ATG] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011921.html RLID00011663 3771793 tRNA:N5:42Ac http://www.ncbi.nlm.nih.gov/gene/?term=3771793 "Dmel_CR30518, AE002769.trna6-AsnGTT, CR30307, CR30518, Dmel\CR30518, asn-tRNA, chr2R.trna97-AsnGTT, tRNA:N:GTT:AE002769-b, tRNA:asn5:42Ac " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011933.html RLID00011664 3771794 tRNA:CR30298 http://www.ncbi.nlm.nih.gov/gene/?term=3771794 "Dmel_CR30298, AE002787.trna28-ThrAGT, CR30298, Dmel\CR30298, chr2R.trna87-ThrAGT, tRNA:T3:47F, tRNA:T:AGT:AE002787-b, tRNA:thr3:47F, tRNA[Thr][[3]], tRNA[[Thr]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050298.html RLID00011665 3771795 tRNA:E4:62Ae http://www.ncbi.nlm.nih.gov/gene/?term=3771795 "Dmel_CR32322, AE002584.trna11-GluCTC, CR32322, Dmel\CR32322, chr3L.trna11-GluCTC, glu-trna, tRNA:E4, tRNA:E:CTC:AE002584-i, tRNA:Glu, tRNA:glu4:62Ae " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011855.html RLID00011666 3771804 tRNA:CR30449 http://www.ncbi.nlm.nih.gov/gene/?term=3771804 "Dmel_CR30449, CR30221, CR30449, Dmel\CR30449, chr2R.trna39-GluCTC " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050449.html RLID00011667 3771805 tRNA:I:42A http://www.ncbi.nlm.nih.gov/gene/?term=3771805 "Dmel_CR30313, AE002769.trna15-IleAAT, CR30313, Dmel\CR30313, chr2R.trna7-IleAAT, tRNA Ile, tRNA:I:AAT:AE002769, tRNA:ile:42A, tRNA[Ile] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011880.html RLID00011668 3771815 tRNA:V4:70BCb http://www.ncbi.nlm.nih.gov/gene/?term=3771815 "Dmel_CR32124, AE002602.trna22-ValAAC, CR32124, Dmel\CR32124, chr3L.trna27-ValAAC, tRNA-Val-4, tRNA:V4, tRNA:V:AAC:AE002602-b, tRNA:val4:70BCb, tRNA[Val-AAC], tRNA[Val][[4]], val-tRNA-4, valine tRNA " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012010.html RLID00011669 3771822 tRNA:V3b:92Ba http://www.ncbi.nlm.nih.gov/gene/?term=3771822 "Dmel_CR31214, AE002708.trna41-ValCAC, CR31214, Dmel\CR31214, chr3R.trna47-ValCAC, tRNA:V3b, tRNA:V:CAC:AE002708-c, tRNA:val3b:92Ba, tRNA[Val][[3b]], valine tRNA " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012003.html RLID00011670 3771843 tRNA:CR30227 http://www.ncbi.nlm.nih.gov/gene/?term=3771843 "Dmel_CR30227, AE002787.trna48-TrpCCA, CR30227, Dmel\CR30227, chr2R.trna31-TrpCCA, tRNA:W:CCA:AE002787-b " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050227.html RLID00011671 3771844 tRNA:F2:89BC http://www.ncbi.nlm.nih.gov/gene/?term=3771844 "Dmel_CR31586, AE002708.trna6-PheGAA, CR31586, Dmel\CR31586, chr3R.trna12-PheGAA, phe-tRNA-2, tRNA-Phe-2, tRNA:F:GAA:AE002708-b, tRNA:phe2:89BC " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011858.html RLID00011672 3771847 snoRNA:Psi28S-2179 http://www.ncbi.nlm.nih.gov/gene/?term=3771847 "Dmel_CR33918, CR33918, Dm-734, Dmel\CR33918, Psi28S-2719, Psi28S-2719(SnoR734), SnoR734, psi28S-2179, snoR734, snoRNA:734 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086666.html RLID00011673 3771850 tRNA:V3b:84Dd http://www.ncbi.nlm.nih.gov/gene/?term=3771850 "Dmel_CR31502, AE002699.trna1-ValCAC, CR31502, Dmel\CR31502, Val-3b, chr3R.trna74-ValCAC, tRNA:V3b, tRNA:V:CAC:AE002699-a, tRNA:val3b:84Dd, tRNA[Val][[3b]], valine tRNA " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012001.html RLID00011674 3771867 tRNA:G3:35Bc http://www.ncbi.nlm.nih.gov/gene/?term=3771867 "Dmel_CR31982, AE002690.trna17-GlyGCC, BG:DS04641.5, CR31982, Dmel\CR31982, chr2L.trna26-GlyGCC, tRNA:G:GCC:AE002690-e, tRNA:gly3:35Bc, tRNA[Gly-GCC] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011864.html RLID00011675 3771868 tRNA:G3:57BCb http://www.ncbi.nlm.nih.gov/gene/?term=3771868 "Dmel_CR30210, AE002575.trna3-GlyGCC, CR30210, Dmel\CR30210, chr2R.trna47-GlyGCC, tRNA:G:GCC:AE002575-a, tRNA:gly3:57BCb, tRNA[Gly-GCC] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011872.html RLID00011676 3771872 Hsp67Bb http://www.ncbi.nlm.nih.gov/gene/?term=3771872 "Dmel_CG4456, CG32041, CG4456, Dmel\CG4456, EP(3)3247, Hsp-G2, Hspg2, anon-WO0118547.50, anon-WO0140519.138, gene 2, gene-2, gene2, gene4, hsp67B, hsp67Bb, small hsp locus 67B " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011677 3771881 tRNA:G3:22BCa http://www.ncbi.nlm.nih.gov/gene/?term=3771881 "Dmel_CR31667, AE002638.trna7-GlyGCC, CR31667, Dmel\CR31667, chr2L.trna40-GlyGCC, phe-tRNA-2, tRNA:G:GCC:AE002638-a, tRNA:gly3:22BCa, tRNA[Gly-GCC] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011859.html RLID00011678 3771882 tRNA:G3:53E http://www.ncbi.nlm.nih.gov/gene/?term=3771882 "Dmel_CR30236, AE002787.trna44-GlyGCC, CR30236, Dmel\CR30236, chr2R.trna27-GlyGCC, tRNA:G:GCC:AE002787-b, tRNA:gly3:53E, tRNA[Gly-GCC] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011867.html RLID00011679 3771886 snoRNA:Psi28S-3342 http://www.ncbi.nlm.nih.gov/gene/?term=3771886 "Dmel_CR33787, CR33787, Dm-644, Dmel\CR33787, Psi28S-3342(SnoR644), psi28s-3342, snoR644, snoRNA:644 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086667.html RLID00011680 3771887 tRNA:CR30212 http://www.ncbi.nlm.nih.gov/gene/?term=3771887 "Dmel_CR30212, AE002787.trna2-ArgCCT, CR30133, CR30212, Dmel\CR30212, chr2R.trna60-ArgCCT, tRNA:R:CCT:AE002787-a " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050212.html RLID00011681 3771898 tRNA:CR30220 http://www.ncbi.nlm.nih.gov/gene/?term=3771898 "Dmel_CR30220, AE002787.trna55-GluCTC, CR30220, Dmel\CR30220, FBgn:0050220, chr2R.trna38-GluCTC, tRNA:E:CTC:AE002787-b " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050220.html RLID00011682 3771899 tRNA:CR32456 http://www.ncbi.nlm.nih.gov/gene/?term=3771899 "Dmel_CR32456, AE002647.trna1-LeuCAG, CR32456, Dmel\CR32456, chr3L.trna32-LeuCAG, tRNA:L2:79F, tRNA:L:CAG:AE002647, tRNA:leu2:79F, tRNA[LEU], tRNA[Leu], tRNA[Leu][[2]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0266585.html RLID00011683 3771901 snoRNA:Psi28S-1180 http://www.ncbi.nlm.nih.gov/gene/?term=3771901 "Dmel_CR33661, CR33661, Dm-535, Dmel\CR33661, Psi 28S-1180(SnoR535), chr2R:7107301..7107415, psi28s-1180, snoR535, snoRNA:535 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086658.html RLID00011684 3771919 tRNA:Y1:28C http://www.ncbi.nlm.nih.gov/gene/?term=3771919 "Dmel_CR31905, CR31905, Dmel\CR31905, Tyr-tRNA, tRNA-Tyr, tRNA:Y, tRNA:tyr1:28C, tRNA[Tyr], tRNA[Tyr][[1gamma]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012018.html RLID00011685 3771937 tRNA:CR30257 http://www.ncbi.nlm.nih.gov/gene/?term=3771937 "Dmel_CR30257, AE002787.trna32-ThrTGT, CR30257, Dmel\CR30257, chr2R.trna14-ThrTGT, tRNA:T3:47F, tRNA:T:TGT:AE002787-c, tRNA:thr3:47F, tRNA[Thr][[3]], tRNA[[Thr]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050257.html RLID00011686 3771962 snoRNA:Psi28S-2622 http://www.ncbi.nlm.nih.gov/gene/?term=3771962 "Dmel_CR33656, CR33656, Dm-3, Dmel\CR33656, Psi28S-2622(SnoR3), chr3L:1472428..1472587, psi28s-2622, snoR3, snoRNA:3 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086670.html RLID00011687 3771971 tRNA:M2:48Ba http://www.ncbi.nlm.nih.gov/gene/?term=3771971 "Dmel_CR30255, AE002787.trna34-MetCAT, CR30255, Dmel\CR30255, chr2R.trna16-MetCAT, tRNA:M:CAT:AE002787-d, tRNA:met2:48Ba " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011915.html RLID00011688 3771986 tRNA:R2:84Fc http://www.ncbi.nlm.nih.gov/gene/?term=3771986 "Dmel_CR31582, AE002708.trna64-ArgACG, CR31582, Dmel\CR31582, chr3R.trna70-ArgACG, tRNA:R1, tRNA:R:ACG:AE002708-c, tRNA:arg1, tRNA:arg2:84Fc, tRNA[Arg][[2]], tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011961.html RLID00011689 3771990 tRNA:V4:89BC http://www.ncbi.nlm.nih.gov/gene/?term=3771990 "Dmel_CR31587, AE002708.trna7-ValAAC, CR31587, Dmel\CR31587, chr3R.trna13-ValAAC, tRNA-Val-4, tRNA:V4, tRNA:V:AAC:AE002708-a, tRNA:val4:89BC, tRNA[Val-AAC], tRNA[Val][[4]], val-tRNA-4, valine tRNA " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012011.html RLID00011690 3772000 tRNA:V3b:84Dc http://www.ncbi.nlm.nih.gov/gene/?term=3772000 "Dmel_CR31500, AE002699.trna2-ValCAC, CR31500, Dmel\CR31500, Val-3b, chr3R.trna75-ValCAC, tRNA:V3b, tRNA:V:CAC:AE002699-b, tRNA:val3b:84Dc, tRNA[Val][[3b]], valine tRNA " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012000.html RLID00011691 3772005 tRNA:CR30299 http://www.ncbi.nlm.nih.gov/gene/?term=3772005 "Dmel_CR30299, AE002787.trna27-ThrAGT, CR30299, Dmel\CR30299, chr2R.trna86-ThrAGT, tRNA:T3:47F, tRNA:T:AGT:AE002787-a, tRNA:thr3:47F, tRNA[Thr][[3]], tRNA[[Thr]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050299.html RLID00011692 3772008 tRNA:K5:29A http://www.ncbi.nlm.nih.gov/gene/?term=3772008 "Dmel_CR31899, AE002690.trna3-LysTTT, CR31899, Dmel\CR31899, chr2L.trna11-LysTTT, lys-tRNA-5, tRNA:K5, tRNA:K:TTT:AE002690, tRNA:lys5:29A " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011902.html RLID00011693 3772020 tRNA:R2:42Ab http://www.ncbi.nlm.nih.gov/gene/?term=3772020 "Dmel_CR30314, AE002769.trna16-ArgACG, CR30314, Dmel\CR30314, chr2R.trna8-ArgACG, tRNA Arg, tRNA:R1, tRNA:R:ACG:AE002769-d, tRNA:arg1, tRNA:arg2:42Ab, tRNA[Arg], tRNA[Arg][[2]], tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011956.html RLID00011694 3772021 tRNA:G3:35Bd http://www.ncbi.nlm.nih.gov/gene/?term=3772021 "Dmel_CR31981, AE002690.trna16-GlyGCC, BG:DS04641.6, CR31981, Dmel\CR31981, chr2L.trna25-GlyGCC, tRNA:G:GCC:AE002690-d, tRNA:gly3:35Bd, tRNA[Gly-GCC] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011865.html RLID00011695 3772022 tRNA:R2:42Ad http://www.ncbi.nlm.nih.gov/gene/?term=3772022 "Dmel_CR30304, 35DArg, AE002769.trna10-ArgACG, CR30304, Dmel\CR30304, chr2R.trna1-ArgACG, tRNA:R1, tRNA:R:ACG:AE002769-b, tRNA:arg1, tRNA:arg2:42Ad, tRNA[Arg], tRNA[Arg][[2]], tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011958.html RLID00011696 3772023 tRNA:CR30406 http://www.ncbi.nlm.nih.gov/gene/?term=3772023 "Dmel_CR30406, AE002575.trna10-GlyTCC, CR30204, CR30406, Dmel\CR30406, chr2R.trna54-GlyTCC, tRNA:G:58AB, tRNA:G:TCC:AE002575-a, tRNA:gly:58AB, tRNA[Gly][[GGA]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050406.html RLID00011697 3772026 tRNA:L2:44EF http://www.ncbi.nlm.nih.gov/gene/?term=3772026 "Dmel_CR30292, AE002787.trna30-LeuCAG, CR30292, Dmel\CR30292, chr2R.trna12-LeuCAG, tRNA:L:CAG:AE002787, tRNA:leu2:44EF, tRNA[LEU], tRNA[Leu], tRNA[Leu][[2]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011906.html RLID00011698 3772033 tRNA:K5:84ABa http://www.ncbi.nlm.nih.gov/gene/?term=3772033 "Dmel_CR31486, AE002699.trna4-LysTTT, BG:DS00276.1, CR31486, Dmel\CR31486, Lys-5, chr3R.trna77-LysTTT, lys-tRNA-5, lys5:84ABa, tRNA:K5, tRNA:K:TTT:AE002699-a, tRNA:lys5:84AB " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011904.html RLID00011699 3772036 tRNA:CR30316 http://www.ncbi.nlm.nih.gov/gene/?term=3772036 "Dmel_CR30316, AE002769.trna17-ArgACG, CR30316, Dmel\CR30316, chr2R.trna9-ArgACG, tRNA:R:ACG:AE002769-e " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050316.html RLID00011700 3772043 tRNA:I:49Fa http://www.ncbi.nlm.nih.gov/gene/?term=3772043 "Dmel_CR32842, AE002787.trna18-IleAAT, CR32839, CR32842, Dmel\CR32842, chr2R.trna77-IleAAT, ile-a, tRNA:I:AAT:AE002787-a, tRNA:ile:49Fa, tRNA[Ile] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011881.html RLID00011701 3772045 tRNA:R2:84Fd http://www.ncbi.nlm.nih.gov/gene/?term=3772045 "Dmel_CR31585, AE002708.trna65-ArgACG, CR31585, Dmel\CR31585, chr3R.trna71-ArgACG, tRNA:R1, tRNA:R:ACG:AE002708-d, tRNA:arg1, tRNA:arg2:84Fd, tRNA[Arg][[2]], tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011962.html RLID00011702 3772055 snoRNA:Psi18S-1377a http://www.ncbi.nlm.nih.gov/gene/?term=3772055 "Dmel_CR33750, CR33750, Dm-328, Dmel\CR33750, Psi 18S-1377a(SnoR328), Psi18S-1377a, chr3R:26033540..26033785, psi18S-1377a, snoR328, snoRNA:328 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086665.html RLID00011703 3772062 tRNA:Y1:85Ac http://www.ncbi.nlm.nih.gov/gene/?term=3772062 "Dmel_CR31434, 85Ac, AE002708.trna59-TyrGTA, CR31434, Dmel\CR31434, Tyr-tRNA T85c, chr3R.trna65-TyrGTA, tRNA-Tyr, tRNA:Y, tRNA:Y:GTA:AE002708-c, tRNA:tyr1:85Ac, tRNA[Tyr], tRNA[Tyr][[1gamma]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012026.html RLID00011704 3772067 tRNA:CR30229 http://www.ncbi.nlm.nih.gov/gene/?term=3772067 "Dmel_CR30229, AE002787.trna49-LeuAAG, CR30229, Dmel\CR30229, chr2R.trna32-LeuAAG, tRNA:L:AAG:AE002787-d " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050229.html RLID00011705 3772072 tRNA:G3:55E http://www.ncbi.nlm.nih.gov/gene/?term=3772072 "Dmel_CR30228, AE002787.trna10-GlyGCC, CR30228, Dmel\CR30228, chr2R.trna68-GlyGCC, tRNA:G:GCC:AE002787-a, tRNA:gly3:55E, tRNA[Gly-GCC] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011868.html RLID00011706 3772079 tRNA:E4:62Ad http://www.ncbi.nlm.nih.gov/gene/?term=3772079 "Dmel_CR32323, AE002584.trna10-GluCTC, CR32323, Dmel\CR32323, chr3L.trna10-GluCTC, tRNA:E4, tRNA:E:CTC:AE002584-h, tRNA:Glu, tRNA:glu4:62Ad " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011854.html RLID00011707 3772089 tRNA:CR30333 http://www.ncbi.nlm.nih.gov/gene/?term=3772089 "Dmel_CR30333, AE002787.trna11-PheGAA, CR30230, CR30333, Dmel\CR30333, chr2R.trna69-PheGAA, tRNA:F:GAA:AE002787-a " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050333.html RLID00011708 3772090 tRNA:M3:70Fb http://www.ncbi.nlm.nih.gov/gene/?term=3772090 "Dmel_CR32144, AE002602.trna23-MetCAT, CR32144, Dmel\CR32144, chr3L.trna28-MetCAT, tRNA:M:CAT:AE002602-b, tRNA:met3:70Fb, tRNA[Met-ATG] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011928.html RLID00011709 3772095 tRNA:R:12Ea http://www.ncbi.nlm.nih.gov/gene/?term=3772095 "Dmel_CR32622, AE002593.trna4-ArgTCG, CR32622, Dmel\CR32622, chrX.trna8-ArgTCG, tRNA-Arg, tRNA:R1, tRNA:R:TCG:AE002593-b, tRNA:arg1, tRNA:arg12Ea, tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011948.html RLID00011710 3772114 tRNA:G3:22BCb http://www.ncbi.nlm.nih.gov/gene/?term=3772114 "Dmel_CR31945, AE002638.trna11-GlyGCC, CR31945, Dmel\CR31945, chr2L.trna4-GlyGCC, tRNA:G:GCC:AE002638-b, tRNA:gly3:22BCb, tRNA[Gly-GCC] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011860.html RLID00011711 3772118 tRNA:K2:42Ad http://www.ncbi.nlm.nih.gov/gene/?term=3772118 "Dmel_CR30515, 35SLys, AE002769.trna3-LysCTT, CR30315, CR30515, Dmel\CR30515, chr2R.trna94-LysCTT, tRNA:K2, tRNA:K:CTT:AE002769-a, tRNA:lys2:42Ad, tRNA[Lys][[2]], tRNAlys " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011890.html RLID00011712 3772119 snoRNA:Psi28S-3436b http://www.ncbi.nlm.nih.gov/gene/?term=3772119 "Dmel_CR33799, CR33799, Dm-75, Dmel\CR33799, Psi28S-3436b, psi28S-3436b, snoR75, snoRNA:75 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086602.html RLID00011713 3772122 tRNA:N5:42Ab http://www.ncbi.nlm.nih.gov/gene/?term=3772122 "Dmel_CR30511, CR30308, CR30511, Dmel\CR30511, asn-tRNA, chr2R.trna4-AsnGTT, tRNA:asn5:42Ab " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011932.html RLID00011714 3772127 tRNA:Y1:85Ab http://www.ncbi.nlm.nih.gov/gene/?term=3772127 "Dmel_CR31433, 85Ab, AE002708.trna58-TyrGTA, CR31433, Dmel\CR31433, Tyr-tRNA T85b, chr3R.trna64-TyrGTA, tRNA-Tyr, tRNA:Y, tRNA:Y:GTA:AE002708-b, tRNA:tyr1:85Ab, tRNA[Tyr], tRNA[Tyr][[1gamma]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012025.html RLID00011715 3772151 tRNA:CR30250 http://www.ncbi.nlm.nih.gov/gene/?term=3772151 "Dmel_CR30250, AE002787.trna20-HisGTG, CR30250, Dmel\CR30250, chr2R.trna79-HisGTG, tRNA:H:GTG:AE002787-c, tRNA[His] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050250.html RLID00011716 3772161 tRNA:K2:42Ec http://www.ncbi.nlm.nih.gov/gene/?term=3772161 "Dmel_CR30302, AE002778.trna2-LysCTT, CR30302, Dmel\CR30302, chr2R.trna89-LysCTT, tRNA:K2, tRNA:K:CTT:AE002778-b, tRNA:lys2:42Ec, tRNA[Lys][[2]], tRNAlys " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011894.html RLID00011717 3772168 tRNA:CR30215 http://www.ncbi.nlm.nih.gov/gene/?term=3772168 "Dmel_CR30215, AE002787.trna53-IleAAT, CR30215, Dmel\CR30215, chr2R.trna36-IleAAT, tRNA:I:AAT:AE002787-h " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050215.html RLID00011718 3772177 tRNA:I:49Fd http://www.ncbi.nlm.nih.gov/gene/?term=3772177 "Dmel_CR30246, AE002787.trna39-IleAAT, CR30246, Dmel\CR30246, chr2R.trna21-IleAAT, ile-d, tRNA:I:AAT:AE002787-e, tRNA:ile:49Fd, tRNA[Ile] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011884.html RLID00011719 3772187 tRNA:G3:56EFa http://www.ncbi.nlm.nih.gov/gene/?term=3772187 "Dmel_CR30214, AE002787.trna58-GlyGCC, CR30137, CR30214, Dmel\CR30214, chr2R.trna42-GlyGCC, tRNA:G:GCC:AE002787-c, tRNA:gly3:56EFa, tRNA[Gly-GCC] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011869.html RLID00011720 3772194 tRNA:CR30200 http://www.ncbi.nlm.nih.gov/gene/?term=3772194 "Dmel_CR30200, AE002575.trna8-AlaCGC, CR30200, Dmel\CR30200, chr2R.trna52-AlaCGC, tRNA:A:CGC:AE002575-c, tRNA[[Ala]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050200.html RLID00011721 3772195 tRNA:G3:28D http://www.ncbi.nlm.nih.gov/gene/?term=3772195 "Dmel_CR31903, AE002690.trna2-GlyGCC, CR31903, Dmel\CR31903, chr2L.trna10-GlyGCC, tRNA:G:GCC:AE002690-a, tRNA:gly3:28D, tRNA[Gly-GCC] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011861.html RLID00011722 3772201 tRNA:V3b:92Bb http://www.ncbi.nlm.nih.gov/gene/?term=3772201 "Dmel_CR31430, AE002708.trna20-ValCAC, CR31430, Dmel\CR31430, chr3R.trna26-ValCAC, tRNA:V3b, tRNA:V3b:92Bc, tRNA:V3b:92Bd, tRNA:V:CAC:AE002708-b, tRNA:val3b:92Bb, tRNA:val3b:92Bc, tRNA:val3b:92Bd, tRNA[Val][[3b]], valine tRNA " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012004.html RLID00011723 3772202 tRNA:G3:56EFb http://www.ncbi.nlm.nih.gov/gene/?term=3772202 "Dmel_CR30138, AE002787.trna59-GlyGCC, CR30138, Dmel\CR30138, chr2R.trna43-GlyGCC, tRNA:G:GCC:AE002787-d, tRNA:gly3:56EFb, tRNA[Gly-GCC] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011870.html RLID00011724 3772214 tRNA:N5:42Ah http://www.ncbi.nlm.nih.gov/gene/?term=3772214 "Dmel_CR30513, AE002769.trna8-AsnGTT, Asn-tRNA-8, Asn8, CR30305, CR30513, Dmel\CR30513, chr2R.trna99-AsnGTT, tRNA:N:GTT:AE002769-d, tRNA:asn5:42Ah, tRNA[Asn] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011938.html RLID00011725 3772226 tRNA:CR30231 http://www.ncbi.nlm.nih.gov/gene/?term=3772226 "Dmel_CR30231, AE002787.trna47-PheGAA, CR30107, CR30231, Dmel\CR30231, chr2R.trna30-PheGAA, tRNA:F:GAA:AE002787-b " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050231.html RLID00011726 3772227 snoRNA:Psi18S-841a http://www.ncbi.nlm.nih.gov/gene/?term=3772227 "Dmel_CR33765, CR33765, Dm-66, Dmel\CR33765, Psi 18S-841a(SnoR66), Psi18S-841a, psi-18S-841a, psi18S-841a, snoR66, snoRNA:66 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086669.html RLID00011727 3772235 snoRNA:Psi28S-2876 http://www.ncbi.nlm.nih.gov/gene/?term=3772235 "Dmel_CR33646, CR33646, Dm-825, Dmel\CR33646, Psi28S-2876, Psi28S-2876(SnoR825), psi28S-2876, snoR825, snoRNA:825 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086671.html RLID00011728 3772238 snoRNA:Or-CD2 http://www.ncbi.nlm.nih.gov/gene/?term=3772238 "Dmel_CR33636, CR33636, Dm-461, DmOr_cd2 snoRNA, DmOr_cd2(SnoR461), Dmel\CR33636, Or-CD2, chr2R:4608869..4608988, orphan-CD2, snoR461, snoRNA:461, snoRNA:Or-cd2 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086603.html RLID00011729 3772242 tRNA:L3:49Fa http://www.ncbi.nlm.nih.gov/gene/?term=3772242 "Dmel_CR32841, AE002787.trna17-LeuCAA, CR32840, CR32841, Dmel\CR32841, DtL[a], chr2R.trna76-LeuCAA, leu-a, tRNA:L:CAA:AE002787-a, tRNA:leu3:49Fa, tRNA[LEU], tRNA[Leu] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011909.html RLID00011730 3772273 tRNA:CR30241 http://www.ncbi.nlm.nih.gov/gene/?term=3772273 "Dmel_CR30241, AE002787.trna15-LeuAAG, CR30241, Dmel\CR30241, chr2R.trna74-LeuAAG, tRNA:L:AAG:AE002787-b " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050241.html RLID00011731 3772279 tRNA:G3:35Ba http://www.ncbi.nlm.nih.gov/gene/?term=3772279 "Dmel_CR31977, AE002690.trna10-GlyGCC, BG:DS04641.3, CR31977, Dmel\CR31977, chr2L.trna19-GlyGCC, tRNA:G:GCC:AE002690-b, tRNA:gly3:35Ba, tRNA[Gly-GCC] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011862.html RLID00011732 3772281 tRNA:CR30225 http://www.ncbi.nlm.nih.gov/gene/?term=3772281 "Dmel_CR30225, AE002787.trna51-ValAAC, CR30225, Dmel\CR30225, chr2R.trna34-ValAAC, tRNA:V4:56D, tRNA:V:AAC:AE002787-a, tRNA:val4:56D, tRNA[Val-AAC], tRNA[Val][[4]], valine tRNA " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050225.html RLID00011733 3772286 tRNA:CR30240 http://www.ncbi.nlm.nih.gov/gene/?term=3772286 "Dmel_CR30240, AE002787.trna43-GluTTC, CR30240, Dmel\CR30240, chr2R.trna26-GluTTC, tRNA:E4:53A, tRNA:E:TTC:AE002787-e, tRNA:Glu, tRNA:glu4:53A " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050240.html RLID00011734 3772296 tRNA:CR30201 http://www.ncbi.nlm.nih.gov/gene/?term=3772296 "Dmel_CR30201, AE002575.trna9-SerTGA, CR30201, Dmel\CR30201, chr2R.trna53-SerTGA, chr2R:18579596..18579746, tRNA:S:TGA:AE002575-b, tRNA[[Ser]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050201.html RLID00011735 3772297 CR32730 http://www.ncbi.nlm.nih.gov/gene/?term=3772297 "Dmel_ BcDNA:RE54930, Dmel\CR32730, MRE32 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011736 3772298 snoRNA:Or-aca5 http://www.ncbi.nlm.nih.gov/gene/?term=3772298 "Dmel_CR33637, CR33637, Dm-227, DmOr_aca5, DmOr_aca5 snoRNA, DmOr_aca5(SnoR227), Dmel\CR33637, Or-aca5, chr2R:4607488..4607590, snoR227, snoRNA:227 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086672.html RLID00011737 3772303 tRNA:CR30232 http://www.ncbi.nlm.nih.gov/gene/?term=3772303 "Dmel_CR30232, AE002787.trna12-AlaTGC, CR30232, Dmel\CR30232, chr2R.trna70-AlaTGC, tRNA:A:TGC:AE002787-a, tRNA[[Ala]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050232.html RLID00011738 3772309 tRNA:CR30237 http://www.ncbi.nlm.nih.gov/gene/?term=3772309 "Dmel_CR30237, AE002787.trna14-GlnCTG, CR30237, Dmel\CR30237, chr2R.trna73-GlnCTG, tRNA:Q:CTG:AE002787 " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050237.html RLID00011739 3772310 tRNA:R2:84Fb http://www.ncbi.nlm.nih.gov/gene/?term=3772310 "Dmel_CR31566, AE002708.trna63-ArgACG, CR31566, Dmel\CR31566, chr3R.trna69-ArgACG, tRNA:R1, tRNA:R:ACG:AE002708-b, tRNA:arg1, tRNA:arg2:84Fb, tRNA[Arg][[2]], tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011960.html RLID00011740 3772318 tRNA:M2:83F http://www.ncbi.nlm.nih.gov/gene/?term=3772318 "Dmel_CR31310, AE002699.trna7-MetCAT, CR31310, Dmel\CR31310, Met-2, chr3R.trna80-MetCAT, tRNA:M:CAT:AE002699, tRNA:met2:83F, tRNA[[e]][Met] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011919.html RLID00011741 3772321 tRNA:CR30235 http://www.ncbi.nlm.nih.gov/gene/?term=3772321 "Dmel_CR30235, AE002787.trna45-LeuAAG, CR30235, Dmel\CR30235, chr2R.trna28-LeuAAG, tRNA:L:AAG:AE002787-c " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050235.html RLID00011742 3772323 snoRNA:Psi28S-3436a http://www.ncbi.nlm.nih.gov/gene/?term=3772323 "Dmel_CR33751, CR33751, Dm-708, Dmel\CR33751, Psi 28S-3436a(SnoR708), Psi28S-3436a, psi28S-3436a, snoR708, snoRNA:708 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086668.html RLID00011743 3772331 tRNA:G3:35Be http://www.ncbi.nlm.nih.gov/gene/?term=3772331 "Dmel_CR31980, AE002690.trna15-GlyGCC, BG:DS04641.7, CR31980, Dmel\CR31980, chr2L.trna24-GlyGCC, tRNA:G:GCC:AE002690-c, tRNA:gly3:35Be, tRNA[Gly-GCC] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011866.html RLID00011744 3772335 tRNA:Y1:85Aa http://www.ncbi.nlm.nih.gov/gene/?term=3772335 "Dmel_CR31435, 85Aa, AE002708.trna57-TyrGTA, CR31435, Dmel\CR31435, Tyr-tRNA T85a, chr3R.trna63-TyrGTA, tRNA-Tyr, tRNA:Y, tRNA:Y:GTA:AE002708-a, tRNA:tyr1:85Aa, tRNA[Tyr], tRNA[Tyr][[1gamma]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012024.html RLID00011745 3772340 tRNA:CR30234 http://www.ncbi.nlm.nih.gov/gene/?term=3772340 "Dmel_CR30234, AE002787.trna13-LeuAAG, CR30234, Dmel\CR30234, chr2R.trna71-LeuAAG, tRNA:L:AAG:AE002787-a " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050234.html RLID00011746 3772347 tRNA:Y1:22Fb http://www.ncbi.nlm.nih.gov/gene/?term=3772347 "Dmel_CR31986, AE002638.trna3-TyrGTA, CR31986, Dmel\CR31986, chr2L.trna36-TyrGTA, tRNA-Tyr, tRNA:Y, tRNA:Y:GTA:AE002638-a, tRNA:tyr1:22Fb, tRNA[Tyr], tRNA[Tyr][[1gamma]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012017.html RLID00011747 3772356 tRNA:R:19F http://www.ncbi.nlm.nih.gov/gene/?term=3772356 "Dmel_CR32526, AE002620.trna3-ArgTCG, CR32526, Dmel\CR32526, chrX.trna16-ArgTCG, tRNA-Arg, tRNA:R1, tRNA:R:TCG:AE002620, tRNA:arg1, tRNA:arg19F, tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011954.html RLID00011748 3772362 tRNA:H:48F http://www.ncbi.nlm.nih.gov/gene/?term=3772362 "Dmel_CR30252, AE002787.trna35-HisGTG, CR30252, Dmel\CR30252, His-tRNA, His-tRNA-gtg-gamma, chr2R.trna17-HisGTG, tRNA:H:GTG:AE002787-e, tRNA:His, tRNA:his:48F, tRNA[His-48], tRNA[His] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011878.html RLID00011749 3772366 tRNA:M3:70Fa http://www.ncbi.nlm.nih.gov/gene/?term=3772366 "Dmel_CR32142, AE002602.trna2-MetCAT, CR32142, Dmel\CR32142, chr3L.trna36-MetCAT, tRNA:M:CAT:AE002602-a, tRNA:met3:70Fa, tRNA[Met-ATG] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011927.html RLID00011750 3772368 tRNA:K2:56EF http://www.ncbi.nlm.nih.gov/gene/?term=3772368 "Dmel_CR30520, AE002787.trna56-LysCTT, CR30520, Dmel\CR30520, chr2R.trna40-LysCTT, tRNA:K2, tRNA:K:CTT:AE002787-b, tRNA:lys2:56EF, tRNA[Lys][[2]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011897.html RLID00011751 3772369 tRNA:R:12Eb http://www.ncbi.nlm.nih.gov/gene/?term=3772369 "Dmel_CR32620, AE002593.trna5-ArgTCG, CR32620, Dmel\CR32620, chrX.trna9-ArgTCG, tRNA-Arg, tRNA:R1, tRNA:R:TCG:AE002593-c, tRNA:arg1, tRNA:arg12Eb, tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011949.html RLID00011752 3772373 tRNA:Y1:85Ae http://www.ncbi.nlm.nih.gov/gene/?term=3772373 "Dmel_CR31387, 85Ae, AE002708.trna61-TyrGTA, CR31387, Dmel\CR31387, Tyr-tRNA, chr3R.trna67-TyrGTA, tRNA-Tyr, tRNA:Y, tRNA:Y:GTA:AE002708-e, tRNA:tyr1:85Ae, tRNA[Tyr], tRNA[Tyr][[1gamma]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012028.html RLID00011753 3772376 roX1 http://www.ncbi.nlm.nih.gov/gene/?term=3772376 "Dmel_CR32777, BcDNA:GH10432, CR32777, Dmel\CR32777, EG:EG0002.2, RoX1, chrX:3706836..3706970, roX, rox1 " lncRNA Drosophila melanogaster 25332394 Nucleus - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/rox1-and-rox2/ RLID00011754 3772376 roX1 http://www.ncbi.nlm.nih.gov/gene/?term=3772376 "Dmel_CR32777, BcDNA:GH10432, CR32777, Dmel\CR32777, EG:EG0002.2, RoX1, chrX:3706836..3706970, roX, rox1 " mRNA Drosophila melanogaster 17923096 Nucleus Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011755 3772382 Plp http://www.ncbi.nlm.nih.gov/gene/?term=3772382 "Dmel_CG33957, AKAP450, CG13459, CG18648, CG33957, CG6735, CP309, Cp309, D-PLP, DPLP, Dmel\CG33957, Dplp, PACT, PLP, cp309, d-plp, dPLP, dplp, l(3)s2172, pPlp, plp " mRNA Drosophila melanogaster 17923096 Centrosome Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00011756 3772394 tRNA:K2:42Ac http://www.ncbi.nlm.nih.gov/gene/?term=3772394 "Dmel_CR30517, 35SLys, AE002769.trna5-LysCTT, CR30310, CR30517, Dmel\CR30517, chr2R.trna96-LysCTT, tRNA:K2, tRNA:K:CTT:AE002769-c, tRNA:lys2:42Ac, tRNA[Lys][[2]], tRNAlys " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011889.html RLID00011757 3772395 tRNA:CR30452 http://www.ncbi.nlm.nih.gov/gene/?term=3772395 "Dmel_CR30452, AE002787.trna7-MetCAT, CR30216, CR30452, Dmel\CR30452, chr2R.trna65-MetCAT, tRNA:M3:56EF, tRNA:M:CAT:AE002787-a, tRNA:met3:56EF, tRNA[Met-ATG] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050452.html RLID00011758 3772404 tRNA:I:49Fe http://www.ncbi.nlm.nih.gov/gene/?term=3772404 "Dmel_CR30247, AE002787.trna40-IleAAT, CR30247, Dmel\CR30247, chr2R.trna22-IleAAT, ile-e, tRNA:I:AAT:AE002787-f, tRNA:ile:49Fe, tRNA[Ile] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011885.html RLID00011759 3772407 tRNA:CR31023 http://www.ncbi.nlm.nih.gov/gene/?term=3772407 "Dmel_CR31023, AE002708.trna32-LeuTAG, CR31023, Dmel\CR31023, chr3R.trna38-LeuTAG, tRNA:L:TAG:AE002708-a " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0051023.html RLID00011760 3772413 tRNA:K5:87BC http://www.ncbi.nlm.nih.gov/gene/?term=3772413 "Dmel_CR31197, AE002708.trna3-LysTTT, CR31197, Dmel\CR31197, chr3R.trna9-LysTTT, tRNA:K5, tRNA:K:TTT:AE002708, tRNA:lys5:87BC " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011905.html RLID00011761 3772415 roX2 http://www.ncbi.nlm.nih.gov/gene/?term=3772415 "Dmel_CR32665, CR32665, Dmel\CR32665, RoX2, roX, rox2 " lncRNA Drosophila melanogaster 25332394 Nucleus - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/rox1-and-rox2/ RLID00011762 3772431 tRNA:K2:42Ae http://www.ncbi.nlm.nih.gov/gene/?term=3772431 "Dmel_CR32837, 35SLys, AE002769.trna9-LysCTT, CR32837, Dmel\CR32837, chr2R.trna100-LysCTT, tRNA:K2, tRNA:K:CTT:AE002769-d, tRNA:lys2:42Ae, tRNA[Lys][[2]], tRNAlys " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011891.html RLID00011763 3772433 tRNA:N5:42Ae http://www.ncbi.nlm.nih.gov/gene/?term=3772433 "Dmel_CR30519, AE002769.trna1-AsnGTT, CR30318, CR30519, Dmel\CR30519, chr2R.trna92-AsnGTT, tRNA:N:GTT:AE002769-a, tRNA:asn5:42Ae " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011935.html RLID00011764 3772444 tRNA:K2:50C http://www.ncbi.nlm.nih.gov/gene/?term=3772444 "Dmel_CR30507, AE002787.trna16-LysCTT, CR30242, CR30507, Dmel\CR30507, chr2R.trna75-LysCTT, tRNA:K2, tRNA:K:CTT:AE002787-a, tRNA:lys2:50C, tRNA[Lys][[2]], tRNAlys " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011896.html RLID00011765 3772446 tRNA:H:56E http://www.ncbi.nlm.nih.gov/gene/?term=3772446 "Dmel_CR30223, AE002787.trna9-HisGTG, CR30223, Dmel\CR30223, chr2R.trna67-HisGTG, tRNA:CR30223, tRNA:H:GTG:AE002787-a, tRNA:his:56E, tRNA[His] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050223.html RLID00011766 3772454 tRNA:CR30251 http://www.ncbi.nlm.nih.gov/gene/?term=3772454 "Dmel_CR30251, AE002787.trna19-HisGTG, CR30251, Dmel\CR30251, chr2R.trna78-HisGTG, tRNA:H:GTG:AE002787-b, tRNA[His] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050251.html RLID00011767 3772460 tRNA:K2:42Ed http://www.ncbi.nlm.nih.gov/gene/?term=3772460 "Dmel_CR30303, AE002778.trna1-LysCTT, CR30303, Dmel\CR30303, chr2R.trna88-LysCTT, tRNA:K2, tRNA:K:CTT:AE002778-a, tRNA:lys2:42Ed, tRNA[Lys][[2]], tRNAlys " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011895.html RLID00011768 3772465 tRNA:N5:42Aa http://www.ncbi.nlm.nih.gov/gene/?term=3772465 "Dmel_CR30510, AE002769.trna13-AsnGTT, CR30309, CR30510, Dmel\CR30510, asn-tRNA, chr2R.trna5-AsnGTT, tRNA:N:GTT:AE002769-f, tRNA:asn5:42Aa " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011931.html RLID00011769 3772466 tRNA:CR30202 http://www.ncbi.nlm.nih.gov/gene/?term=3772466 "Dmel_CR30202, AE002575.trna4-SerTGA, CR30202, Dmel\CR30202, chr2R.trna48-SerTGA, tRNA:S:TGA:AE002575-a, tRNA[[Ser]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050202.html RLID00011770 3772473 tRNA:R2:42Aa http://www.ncbi.nlm.nih.gov/gene/?term=3772473 "Dmel_CR30514, AE002769.trna2-ArgACG, CR30317, CR30514, DROTG121, Dmel\CR30514, chr2R.trna93-ArgACG, tRNA:R1, tRNA:R:ACG:AE002769-a, tRNA:arg1, tRNA:arg2:42Aa, tRNA[Arg], tRNA[Arg][[2]], tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011955.html RLID00011771 3772480 tRNA:CR30198 http://www.ncbi.nlm.nih.gov/gene/?term=3772480 "Dmel_CR30198, AE002575.trna6-AlaCGC, CR30198, Dmel\CR30198, chr2R.trna50-AlaCGC, tRNA:A:CGC:AE002575-a, tRNA[[Ala]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050198.html RLID00011772 3772486 tRNA:I:49Fb http://www.ncbi.nlm.nih.gov/gene/?term=3772486 "Dmel_CR30244, AE002787.trna37-IleAAT, CR30244, Dmel\CR30244, chr2R.trna19-IleAAT, ile-b, tRNA:I:AAT:AE002787-c, tRNA:ile:49Fb, tRNA[Ile] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011882.html RLID00011773 3772487 tRNA:CR30155 http://www.ncbi.nlm.nih.gov/gene/?term=3772487 "Dmel_CR30155, AE002787.trna60-TrpCCA, CR30155, Dmel\CR30155, chr2R.trna44-TrpCCA, tRNA:W:CCA:AE002787-c " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050155.html RLID00011774 3772488 tRNA:CR30238 http://www.ncbi.nlm.nih.gov/gene/?term=3772488 "Dmel_CR30238, CR30238, Dmel\CR30238, chr2R.trna72-GluTTC, tRNA:E4:53A, tRNA:Glu, tRNA:glu4:53A " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050238.html RLID00011775 3772491 tRNA:R:83AB http://www.ncbi.nlm.nih.gov/gene/?term=3772491 "Dmel_CR31593, AE002681.trna1-ArgTCG, CR31593, Dmel\CR31593, chr3R.trna1-ArgTCG, tRNA-Arg, tRNA:R1, tRNA:R:TCG:AE002681, tRNA:arg1, tRNA:arg83AB, tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011965.html RLID00011776 3772498 tRNA:CR30254 http://www.ncbi.nlm.nih.gov/gene/?term=3772498 "Dmel_CR30254, AE002787.trna23-ArgTCT, CR30254, Dmel\CR30254, chr2R.trna82-ArgTCT, tRNA:R:TCT:AE002787 " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050254.html RLID00011777 37724 bw http://www.ncbi.nlm.nih.gov/gene/?term=37724 "Dmel_CG17632, CG17632, Dmel\CG17632, Pm, Su(w[co2]), Su(w[coJ]), ptm " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011778 3772507 tRNA:K2:42Ea http://www.ncbi.nlm.nih.gov/gene/?term=3772507 "Dmel_CR30300, AE002778.trna4-LysCTT, CR30300, Dmel\CR30300, chr2R.trna91-LysCTT, tRNA:K2, tRNA:K4, tRNA:K:CTT:AE002778-d, tRNA:lys2:42Ea, tRNA[Lys][[2]], tRNAlys " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011892.html RLID00011779 3772508 tRNA:V3b:90BC http://www.ncbi.nlm.nih.gov/gene/?term=3772508 "Dmel_CR31572, AE002708.trna9-ValCAC, CR31572, Dmel\CR31572, Val, chr3R.trna15-ValCAC, tRNA:V3b, tRNA:V:CAC:AE002708-a, tRNA:val3b:90BC, tRNA[Val][[3b]], valine tRNA " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012002.html RLID00011780 3772512 tRNA:CR30326 http://www.ncbi.nlm.nih.gov/gene/?term=3772512 "Dmel_CR30326, AE002787.trna52-ValAAC, CR30226, CR30326, Dmel\CR30326, chr2R.trna35-ValAAC, tRNA:V4:56D, tRNA:V:AAC:AE002787-b, tRNA:val4:56D, tRNA[Val-AAC], tRNA[Val][[4]], valine tRNA " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050326.html RLID00011781 3772515 tRNA:R:12Ee http://www.ncbi.nlm.nih.gov/gene/?term=3772515 "Dmel_CR32624, AE002593.trna1-ArgTCG, CR32624, Dmel\CR32624, chrX.trna5-ArgTCG, tRNA-Arg, tRNA:R1, tRNA:R:TCG:AE002593-a, tRNA:arg1, tRNA:arg12Ee, tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011952.html RLID00011782 3772533 tRNA:R2:84Fa http://www.ncbi.nlm.nih.gov/gene/?term=3772533 "Dmel_CR31581, AE002708.trna62-ArgACG, CR31581, Dmel\CR31581, chr3R.trna68-ArgACG, tRNA:R1, tRNA:R:ACG:AE002708-a, tRNA:arg1, tRNA:arg2:84Fa, tRNA[Arg][[2]], tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011959.html RLID00011783 3772544 tRNA:G3:57BCa http://www.ncbi.nlm.nih.gov/gene/?term=3772544 "Dmel_CR30207, AE002575.trna13-GlyGCC, CR30207, Dmel\CR30207, chr2R.trna57-GlyGCC, tRNA:G:GCC:AE002575-b, tRNA:gly3:57BCa, tRNA[Gly-GCC] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011871.html RLID00011784 3772547 Hsromega http://www.ncbi.nlm.nih.gov/gene/?term=3772547 "Dmel_CR31400, CR31400, Dmel\CR31400, HSRomega, Hsr-omega, Hsr93D-n, er3, hrsomega, hsr omega, hsr-omega, hsromega, hsrw, l(3)05241, l(3)93De, l(3)er3, n(3)05241, Hsromega " lncRNA Drosophila melanogaster 10984439 Nucleus Larval|adult cell In situ hybridization "RNA in situ hybridization studies in various larval and adult cell types of Drosophila melanogaster showed that the noncoding hsr-omega nuclear (hsromega-n) transcripts were present in the form of many small speckles. In extreme cases, only a single large cluster of hsromega-n transcripts localizing to the hsromega locus was seen in each nucleus. " RLID00011785 3772547 Hsromega http://www.ncbi.nlm.nih.gov/gene/?term=3772547 "Dmel_CR31400, CR31400, Dmel\CR31400, HSRomega, Hsr-omega, Hsr93D-n, er3, hrsomega, hsr omega, hsr-omega, hsromega, hsrw, l(3)05241, l(3)93De, l(3)er3, n(3)05241, Hsromega " lncRNA Drosophila melanogaster 1704862 Nucleus Schneider S3 cell In situ hybridization "The hsr-omega locus produces three major transcripts,all from the same transcription start site. The largest transcript,omega-1,is>10kb. It is present only in the nucleus. The other nuclear transcript,omega-2,is a 1.9-kb RNA that appears to be produced by alternative termination near either of two polyadenylation signals some 2 kb from the TATA box. The omega-2 RNA does not accumuate to any degree in the nucleus but instead appears to be rapidly spliced and transported to the cytoplasm as omega-3, the 1.2-kb cytoplasmic RNA. " RLID00011786 3772547 Hsromega http://www.ncbi.nlm.nih.gov/gene/?term=3772547 "Dmel_CR31400, CR31400, Dmel\CR31400, HSRomega, Hsr-omega, Hsr93D-n, er3, hrsomega, hsr omega, hsr-omega, hsromega, hsrw, l(3)05241, l(3)93De, l(3)er3, n(3)05241, Hsromega " lncRNA Drosophila melanogaster 17114940 Nucleus Fly cultures In situ hybridization "The hsrw-n transcripts (arrows) in wildv type eye disc cells are distributed as several small speckles in each nucleusc (B and C), but in hsrω05241mutants they are present as 2-3 larger clustersin each nucleus. " RLID00011787 3772554 tRNA:CR30233 http://www.ncbi.nlm.nih.gov/gene/?term=3772554 "Dmel_CR30233, AE002787.trna46-AlaTGC, CR30233, Dmel\CR30233, chr2R.trna29-AlaTGC, tRNA:A:TGC:AE002787-b " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011879.html RLID00011788 3772562 tRNA:CR31071 http://www.ncbi.nlm.nih.gov/gene/?term=3772562 "Dmel_CR31071, AE002708.trna35-GlnTTG, CR31071, Dmel\CR31071, chr3R.trna41-GlnTTG, tRNA:Q:TTG:AE002708-b " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0051071.html RLID00011789 3772564 tRNA:R2:42Ac http://www.ncbi.nlm.nih.gov/gene/?term=3772564 "Dmel_CR30512, AE002769.trna12-ArgACG, Arg-tRNA, CR30306, CR30512, Dmel\CR30512, chr2R.trna3-ArgACG, tRNA:R1, tRNA:R:ACG:AE002769-c, tRNA:arg1, tRNA:arg2:42Ac, tRNA[Arg][[2]], tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011957.html RLID00011790 3772584 tRNA:R:12Ec http://www.ncbi.nlm.nih.gov/gene/?term=3772584 "Dmel_CR32619, AE002593.trna6-ArgTCG, CR32619, Dmel\CR32619, chrX.trna10-ArgTCG, tRNA-Arg, tRNA:R1, tRNA:R:TCG:AE002593-d, tRNA:arg1, tRNA:arg12Ec, tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011950.html RLID00011791 3772585 snoRNA:Psi18S-1347c http://www.ncbi.nlm.nih.gov/gene/?term=3772585 "Dmel_CR33633, CR33633, Dm-203, Dmel\CR33633, Psi18S-1347c, psi18S-1347c, snoR203, snoRNA:203 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086600.html RLID00011792 3772587 tRNA:V4:70BCa http://www.ncbi.nlm.nih.gov/gene/?term=3772587 "Dmel_CR32122, AE002602.trna3-ValAAC, CR32122, Dmel\CR32122, chr3L.trna37-ValAAC, tRNA-Val-4, tRNA:V4, tRNA:V:AAC:AE002602-a, tRNA:val4:70BCa, tRNA[Val-AAC], tRNA[Val][[4]], val-tRNA-4, valine tRNA " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012009.html RLID00011793 3772588 tRNA:K2:42Aa http://www.ncbi.nlm.nih.gov/gene/?term=3772588 "Dmel_CR30312, 35SLys, AE002769.trna14-LysCTT, CR30312, Dmel\CR30312, chr2R.trna6-LysCTT, tRNA-Lys, tRNA:K2, tRNA:K:CTT:AE002769-e, tRNA:lys2:42Aa, tRNA[Lys][[2]], tRNAlys " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011887.html RLID00011794 3772589 tRNA:CR31070 http://www.ncbi.nlm.nih.gov/gene/?term=3772589 "Dmel_CR31070, AE002708.trna34-GlnTTG, CR31070, Dmel\CR31070, chr3R.trna40-GlnTTG, tRNA:Q:TTG:AE002708-a " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0051070.html RLID00011795 3772595 tRNA:CR30454 http://www.ncbi.nlm.nih.gov/gene/?term=3772595 "Dmel_CR30454, AE002787.trna3-GluCTC, CR30454, Dmel\CR30454, chr2R.trna61-GluCTC, tRNA:E:CTC:AE002787-a " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050454.html RLID00011796 3772598 tRNA:Y1:85Ad http://www.ncbi.nlm.nih.gov/gene/?term=3772598 "Dmel_CR31552, 85Ad, AE002708.trna60-TyrGTA, CR31552, Dmel\CR31552, Tyr-tRNA, chr3R.trna66-TyrGTA, tRNA-Tyr, tRNA:Y, tRNA:Y:GTA:AE002708-d, tRNA:tyr1:85Ad, tRNA[Tyr], tRNA[Tyr][[1gamma]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012027.html RLID00011797 3772599 tRNA:R:85Ca http://www.ncbi.nlm.nih.gov/gene/?term=3772599 "Dmel_CR31443, AE002708.trna1-ArgTCG, CR31443, Dmel\CR31443, chr3R.trna7-ArgTCG, tRNA-Arg, tRNA:R1, tRNA:R:TCG:AE002708-a, tRNA:arg1, tRNA:arg85Ca, tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011966.html RLID00011798 3772615 tRNA:CR30218 http://www.ncbi.nlm.nih.gov/gene/?term=3772615 "Dmel_CR30218, AE002787.trna54-MetCAT, CR30218, Dmel\CR30218, chr2R.trna37-MetCAT, tRNA:M3:56EF, tRNA:M:CAT:AE002787-e, tRNA:met3:56EF, tRNA[Met-ATG] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050218.html RLID00011799 3772622 tRNA:K2:42Ab http://www.ncbi.nlm.nih.gov/gene/?term=3772622 "Dmel_CR30516, 35SLys, AE002769.trna4-LysCTT, CR30311, CR30516, Dmel\CR30516, chr2R.trna95-LysCTT, tRNA Lys, tRNA:K2, tRNA:K:CTT:AE002769-b, tRNA:lys2:42Ab, tRNA[Lys][[2]], tRNAlys " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011888.html RLID00011800 3772623 tRNA:M2:48Bb http://www.ncbi.nlm.nih.gov/gene/?term=3772623 "Dmel_CR32844, AE002787.trna22-MetCAT, CR32844, Dmel\CR32844, chr2R.trna81-MetCAT, tRNA:M:CAT:AE002787-b, tRNA:met2:48Bb " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011916.html RLID00011801 3772635 tRNA:Y1:22Fa http://www.ncbi.nlm.nih.gov/gene/?term=3772635 "Dmel_CR31987, AE002638.trna13-TyrGTA, CR31987, Dmel\CR31987, Y22Fa, chr2L.trna6-TyrGTA, tRNA-Tyr, tRNA:Y, tRNA:Y:GTA:AE002638-b, tRNA:tyr1:22Fa, tRNA[Tyr], tRNA[Tyr][[1gamma]] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0012016.html RLID00011802 3772636 tRNA:G3:35Bb http://www.ncbi.nlm.nih.gov/gene/?term=3772636 "Dmel_CR31978, AE002690.trna18-GlyGCC, BG:DS04641.4, CR31978, Dmel\CR31978, chr2L.trna27-GlyGCC, tRNA:G:GCC:AE002690-f, tRNA:gly3:35Bb, tRNA[Gly-GCC] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011863.html RLID00011803 3772643 tRNA:CR30206 http://www.ncbi.nlm.nih.gov/gene/?term=3772643 "Dmel_CR30206, AE002575.trna14-TrpCCA, CR30206, Dmel\CR30206, chr2R.trna58-TrpCCA, tRNA:W:CCA:AE002575-d " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050206.html RLID00011804 3772654 tRNA:CR30211 http://www.ncbi.nlm.nih.gov/gene/?term=3772654 "Dmel_CR30211, AE002787.trna1-TrpCCA, CR30146, CR30211, Dmel\CR30211, chr2R.trna59-TrpCCA, tRNA:W:CCA:AE002787-a " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050211.html RLID00011805 3772657 snoRNA:Psi18S-176 http://www.ncbi.nlm.nih.gov/gene/?term=3772657 "Dmel_CR33913, CR33913, Dm-314, Dmel\CR33913, Psi 18S-176(SnoR314), psi18s-176, snoRNA:314 " snoRNA Drosophila melanogaster 26467478 Nucleolus - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0086659.html RLID00011806 3772658 CG33722 http://www.ncbi.nlm.nih.gov/gene/?term=3772658 "Dmel_ CG18238, CG31188, CG31188-ORFA, Dmel\CG33722 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011807 3772659 tRNA:L3:49Fb http://www.ncbi.nlm.nih.gov/gene/?term=3772659 "Dmel_CR30508, AE002787.trna41-LeuCAA, CR30248, CR30508, Dmel\CR30508, DtL[b], chr2R.trna23-LeuCAA, leu-b, tRNA:L:CAA:AE002787-b, tRNA:leu3:49Fb, tRNA[LEU], tRNA[Leu] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011910.html RLID00011808 3772684 tRNA:CR30297 http://www.ncbi.nlm.nih.gov/gene/?term=3772684 "Dmel_CR30297, AE002787.trna29-IleAAT, CR30297, Dmel\CR30297, chr2R.trna11-IleAAT, tRNA:I:AAT:AE002787-b " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050297.html RLID00011809 3772710 tRNA:R:12Ef http://www.ncbi.nlm.nih.gov/gene/?term=3772710 "Dmel_CR32610, AE002593.trna12-ArgTCG, ArgDm, CR32610, Dmel\CR32610, chrX.trna21-ArgTCG, tRNA:R1, tRNA:R:TCG:AE002593, tRNA:arg1, tRNA:arg12DE, tRNA:arg12Ef, tRNA[arg] " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011953.html RLID00011810 3772714 tRNA:CR30209 http://www.ncbi.nlm.nih.gov/gene/?term=3772714 "Dmel_CR30209, AE002575.trna12-TrpCCA, CR30209, Dmel\CR30209, chr2R.trna56-TrpCCA, tRNA:W:CCA:AE002575-c " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0050209.html RLID00011811 3772717 tRNA:P:90Cb http://www.ncbi.nlm.nih.gov/gene/?term=3772717 "Dmel_CR31571, AE002708.trna11-ProTGG, CR31571, Dmel\CR31571, Pro, chr3R.trna17-ProTGG, tRNA:P:TGG:AE002708-a, tRNA:Pro, tRNA:pro:90Cb " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011945.html RLID00011812 3772718 tRNA:N5:42Ad http://www.ncbi.nlm.nih.gov/gene/?term=3772718 "Dmel_CR30319, AE002769.trna18-AsnGTT, CR30319, Dmel\CR30319, chr2R.trna10-AsnGTT, tRNA:N:GTT:AE002769-g, tRNA:asn5:42Ad " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011934.html RLID00011813 37730 pita http://www.ncbi.nlm.nih.gov/gene/?term=37730 "Dmel_CG3941, CG3941, Dmel\CG3941, PITA, Pita, spdk " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011814 37734 apt http://www.ncbi.nlm.nih.gov/gene/?term=37734 "Dmel_CG5393, 3041, Apt, CG5393, Dmel\CG5393, TDF, TDF/APT, l(2)03041, l(2)06369, l(2)09049, l(2)59Ea, l(2)k11531, tdf " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011815 37742 St1 http://www.ncbi.nlm.nih.gov/gene/?term=37742 "Dmel_CG5428, CG5428, Dmel\CG5428, dmST1, st1 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011816 37742 St1 http://www.ncbi.nlm.nih.gov/gene/?term=37742 "Dmel_CG5428, CG5428, Dmel\CG5428, dmST1, st1 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011817 37757 egl http://www.ncbi.nlm.nih.gov/gene/?term=37757 "Dmel_CG4051, CG4051, Dmel\CG4051, EGL, Egl, egal " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011818 37757 egl http://www.ncbi.nlm.nih.gov/gene/?term=37757 "Dmel_CG4051, CG4051, Dmel\CG4051, EGL, Egl, egal " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011819 3775 KCNK1 http://www.ncbi.nlm.nih.gov/gene/?term=3775 "DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011820 37761 CG5532 http://www.ncbi.nlm.nih.gov/gene/?term=37761 Dmel_ Dmel\CG5532 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011821 377677 CA13 http://www.ncbi.nlm.nih.gov/gene/?term=377677 CAXIII mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011822 377677 CA13 http://www.ncbi.nlm.nih.gov/gene/?term=377677 CAXIII mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011823 377677 CA13 http://www.ncbi.nlm.nih.gov/gene/?term=377677 CAXIII mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011824 3777 KCNK3 http://www.ncbi.nlm.nih.gov/gene/?term=3777 "K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011825 37782 CG4585 http://www.ncbi.nlm.nih.gov/gene/?term=37782 "Dmel_ CK00282, Dmel\CG4585, UD2, anon-60Ab, dCCS4 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011826 377841 ENTPD8 http://www.ncbi.nlm.nih.gov/gene/?term=377841 "E-NTPDase, GLSR2492, NTPDase-8, UNQ2492 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011827 3778 KCNMA1 http://www.ncbi.nlm.nih.gov/gene/?term=3778 "BKTM, KCa1.1, MaxiK, SAKCA, SLO, SLO-ALPHA, SLO1, bA205K10.1, mSLO1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011828 3778 KCNMA1 http://www.ncbi.nlm.nih.gov/gene/?term=3778 "BKTM, KCa1.1, MaxiK, SAKCA, SLO, SLO-ALPHA, SLO1, bA205K10.1, mSLO1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011829 3778 KCNMA1 http://www.ncbi.nlm.nih.gov/gene/?term=3778 "BKTM, KCa1.1, MaxiK, SAKCA, SLO, SLO-ALPHA, SLO1, bA205K10.1, mSLO1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00011830 377 ARF3 http://www.ncbi.nlm.nih.gov/gene/?term=377 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011831 377 ARF3 http://www.ncbi.nlm.nih.gov/gene/?term=377 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011832 37800 kcc http://www.ncbi.nlm.nih.gov/gene/?term=37800 "Dmel_CG5594, BEST:CK01510, CG2768, CG5594, CK01510, Dmel\CG5594, E(sda)J, KCC, Line J, l(2)60A-C, mdcds_17605 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011833 37810 thoc5 http://www.ncbi.nlm.nih.gov/gene/?term=37810 "Dmel_CG2980, CG2980, Dmel\CG2980, THOC5, garm " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011834 37810 thoc5 http://www.ncbi.nlm.nih.gov/gene/?term=37810 "Dmel_CG2980, CG2980, Dmel\CG2980, THOC5, garm " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011835 3781 KCNN2 http://www.ncbi.nlm.nih.gov/gene/?term=3781 "KCa2.2, SK2, SKCA2, SKCa 2, hSK2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011836 37824 Pask http://www.ncbi.nlm.nih.gov/gene/?term=37824 "Dmel_CG3105, CG3105, Dmel\CG3105, pask " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011837 3783 KCNN4 http://www.ncbi.nlm.nih.gov/gene/?term=3783 "DHS2, IK, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011838 378460 Pram1 http://www.ncbi.nlm.nih.gov/gene/?term=378460 AY665714 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011839 378466 Gm10033 http://www.ncbi.nlm.nih.gov/gene/?term=378466 "9330175B10Rik, ENSMUSG00000057924, ENSMUSG00000071083, Gm10311 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011840 378595 znf568 http://www.ncbi.nlm.nih.gov/gene/?term=378595 "XFG 5-2, fg5-2-A " mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00011841 3785 KCNQ2 http://www.ncbi.nlm.nih.gov/gene/?term=3785 "BFNC, EBN, EBN1, ENB1, HNSPC, KCNA11, KV7.2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011842 378665 sox7 http://www.ncbi.nlm.nih.gov/gene/?term=378665 "sox7-A, xSox7 " mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00011843 3786 KCNQ3 http://www.ncbi.nlm.nih.gov/gene/?term=3786 "BFNC2, EBN2, KV7.3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011844 378702 Serf2 http://www.ncbi.nlm.nih.gov/gene/?term=378702 "C80083, Msmac1l, m4F5rel " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00011845 378706 RN7SL2 http://www.ncbi.nlm.nih.gov/gene/?term=378706 "7L1C, 7L30.1, 7SL1c, RNSRP2 " lncRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00011846 378708 APITD1 http://www.ncbi.nlm.nih.gov/gene/?term=378708 "CENP-S, CENPS, FAAP16, MHF1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011847 378805 LINC-PINT http://www.ncbi.nlm.nih.gov/gene/?term=378805 "LincRNA-Pint, MKLN1-AS1, PINT " lncRNA Homo sapiens 24070194 Nucleus Colon cancer cell qRT-PCR "We next investigated the mechanism by which Pint regulates gene expression. We first analyzed the subcellular localization of Pint by RT-qPCR in nuclear versus cytoplasmic fractions, and found that at least 80% of the Pint RNA was present in the cell nucleus (Figure 4A). " RLID00011848 378805 LINC-PINT http://www.ncbi.nlm.nih.gov/gene/?term=378805 "LincRNA-Pint, MKLN1-AS1, PINT " lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00011849 378805 LINC-PINT http://www.ncbi.nlm.nih.gov/gene/?term=378805 "LincRNA-Pint, MKLN1-AS1, PINT " lncRNA Homo sapiens 25630241 Nucleus Hela cell qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00011850 378825 LINC00162 http://www.ncbi.nlm.nih.gov/gene/?term=378825 "C21orf113, NCRNA00162, NLC1-C, NLC1C, PRED74 " lncRNA Homo sapiens 26222413 Nucleus Neuron In situ hybridization|qRT-PCR "In contrast to LINC00162, TRAF3IP2-AS1 transcript showed a surprisingly strong nuclear localization in DA cells (Fig. 2g and h). " RLID00011851 37882 nord http://www.ncbi.nlm.nih.gov/gene/?term=37882 "Dmel_CG30418, CG13574, CG30418, CG3372, Dmel\CG30418, E3272 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011852 37888 betaTub60D http://www.ncbi.nlm.nih.gov/gene/?term=37888 "Dmel_CG3401, 143391_i_at, 3t, B3t, BETA 60D, CG3401, D.m.BETA-60D, DTB3, Dmbeta3, Dmel\CG3401, T, Tub, Tub60D, beta-Tub60D, beta-Tub6D, beta-tub, beta3, beta3 TU, beta3-Tub, beta3-tubulin, beta3TUB, beta3Tub, beta3t, beta3tub, beta60C, betaTub, betaTub3, betaTub60C, beta[[3]] tubulin, beta[[3]]-Tub, beta[[3]]-tubulin, betatub60D, p50, p50/tubulin, p53, p53/tubulin " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011853 37889 slbo http://www.ncbi.nlm.nih.gov/gene/?term=37889 "Dmel_CG4354, C/EBP, CG4354, DC/EBP, DM8, Dm-c/EBP, DmC/EBP, Dmel\CG4354, SLBO, Slbo, fs(2)7, fs(2)8, fs(2)ry7, fs(2)ry8, slobo " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011854 37889 slbo http://www.ncbi.nlm.nih.gov/gene/?term=37889 "Dmel_CG4354, C/EBP, CG4354, DC/EBP, DM8, Dm-c/EBP, DmC/EBP, Dmel\CG4354, SLBO, Slbo, fs(2)7, fs(2)8, fs(2)ry7, fs(2)ry8, slobo " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011855 37890 bs http://www.ncbi.nlm.nih.gov/gene/?term=37890 "Dmel_CG3411, BS, Bs, CG3411, D-SRF, DSRF, DSrf, DSrf/bs, DmSRF, Dmel\CG3411, Group IIc, Mal, SRF, Serf, Srf, ba/DSRF, bs/Dsrf, dSRF, dsrf, l(2)03267, pruned/DSRF, px, srf, bs " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011856 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011857 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 25332394 Cytoplasm - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/mascRNA/ RLID00011858 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 17270048 Nucleus Fibroblast|Lymphoblast In situ hybridization "NEAT2 is extraordinarily well conserved for a noncoding RNA, more so than even XIST. Bioinformatic analyses of publicly available mouse transcriptome data support our findings from human cells as they confirm that the murine homologs of these noncoding RNAs are also nuclear enriched. " RLID00011859 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 19041754 Nucleus HeLa cell Northern blot "Although the long MALAT1 transcript localizes to nuclear speckles, the small RNA is found exclusively in the cytoplasm. " RLID00011860 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 20797886 Nucleus HeLa cell In situ hybridization The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. RLID00011861 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 21128942 Nucleus Brain tissue qRT-PCR|Microarray Table 2: Long noncoding RNAs represented on Affymetrix U133 arrays that were reliably detected in human nucleus accumbens. An lncRNA was considered reliably detected in human NAcc if at least one probe corresponding to the transcript gave a specific signal in all control subjects. No transcripts undetected in the controls were consistently detected in drug abusers. Data are collected from Talbe 2. RLID00011862 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 22070123 Nucleus HeLa cell In situ hybridization "Here, we discuss the functions of a distinct group of vertebrate-specific lncRNAs, NEAT1/MENε/β/VINC, MALAT1/NEAT2, and Gomafu/RNCR2/MIAT, which accumulate abundantly within the nucleus as RNA components of specific nuclear bodies. " RLID00011863 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 22078878 Nucleus HeLa cell|Kidney|Lung fibroblast In situ hybridizationq|RT-PCR "While Pc2 methylation appears to be the key determinant for relocation of growth control genes, based on a methylation/demethylation dependent switch in preference for TUG1 or NEAT2 interactions, respectively, we are tempted to speculate that other ncRNAs recognize covalent modifications of other gene-associated proteins, exerting their ncRNA scaffold functions in distinct subnuclear compartments to act as sensors for many regulated signaling pathways, and as modulators of 'reading' marks on histone tails for a variety of chromodomain-containing proteins and other histone code 'readers'. " RLID00011864 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 23073843 Nucleus HeLa cell Northern blot The MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) locus is misregulated in many human cancers and produces an abundant long nuclear-retained noncoding RNA. RLID00011865 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011866 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 24569078 Nucleus HeLa cell In situ hybridization "Treatment with tubercidin also decreased steady-state MALAT1 long ncRNA, thought to be involved in the retention of SRSF1/SF2 in nuclear speckles. " RLID00011867 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 22855529 Nucleus Hela cell In situ hybridization "Nuclear speckle-associated RNAs include uridine-rich small nuclear RNAs (UsnRNAs), 7SK RNA, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) long ncRNA (lncRNA), and a population of uncharacterized poly(A)+ RNAs (Spector and Lamond, 2011 blue right-pointing triangle). " RLID00011868 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 25332394 Nucleus - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/Malat1/ RLID00011869 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 25332394 Ribosome - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/Malat1/ RLID00011870 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00011871 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 22355166 Nucleus HeLa-TO cell Fluorescence in situ hybridization MALAT-1 noncoding RNA is localized to nuclear speckles despite its mRNA-like characteristics. RLID00011872 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 23152763 Nucleus HeLa cell RT-PCR "MALAT1 localizes to nuclear speckles and interacts with SR splicing factors, and its depletion results in the differential distribution of pre-mRNA splicing factors. " RLID00011873 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, mascRNA " lncRNA Homo sapiens 25630241 Nucleus Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00011874 378 ARF4 http://www.ncbi.nlm.nih.gov/gene/?term=378 ARF2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011875 378 ARF4 http://www.ncbi.nlm.nih.gov/gene/?term=378 ARF2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011876 378 ARF4 http://www.ncbi.nlm.nih.gov/gene/?term=378 ARF2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011877 379025 PSMA3-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=379025 lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00011878 379025 PSMA3-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=379025 lncRNA Homo sapiens 25630241 Nucleus Hela cell qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00011879 379025 PSMA3-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=379025 lncRNA Homo sapiens 25630241 Nucleus Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00011880 379025 PSMA3-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=379025 lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00011881 3790 KCNS3 http://www.ncbi.nlm.nih.gov/gene/?term=3790 KV9.3 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011882 379101 slc18a1 http://www.ncbi.nlm.nih.gov/gene/?term=379101 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00011883 379146 ptpn9 http://www.ncbi.nlm.nih.gov/gene/?term=379146 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00011884 379181 acsbg2 http://www.ncbi.nlm.nih.gov/gene/?term=379181 mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00011885 3791 KDR http://www.ncbi.nlm.nih.gov/gene/?term=3791 "CD309, FLK1, VEGFR, VEGFR2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011886 3792 KEL http://www.ncbi.nlm.nih.gov/gene/?term=3792 "CD238, ECE3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011887 379328 midn-b http://www.ncbi.nlm.nih.gov/gene/?term=379328 mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00011888 379352 MGC53832 http://www.ncbi.nlm.nih.gov/gene/?term=379352 mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00011889 379363 frmd8 http://www.ncbi.nlm.nih.gov/gene/?term=379363 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00011890 3795 KHK http://www.ncbi.nlm.nih.gov/gene/?term=3795 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011891 3795 KHK http://www.ncbi.nlm.nih.gov/gene/?term=3795 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011892 3797 KIF3C http://www.ncbi.nlm.nih.gov/gene/?term=3797 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011893 37982 CG9083 http://www.ncbi.nlm.nih.gov/gene/?term=37982 Dmel_ Dmel\CG9083 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011894 379859 odc1 http://www.ncbi.nlm.nih.gov/gene/?term=379859 "odc-a, odc2, xodc2, odc1 " mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00011895 379888 ccnb1 http://www.ncbi.nlm.nih.gov/gene/?term=379888 mRNA Xenopus laevis 11081630 Mitotic spindle Embryo Whole mount In Situ Hybridization "CPEB, Maskin, and Cyclin B1 mRNA at the mitotic apparatus: implications for local translational control of cell division. " RLID00011896 3798 KIF5A http://www.ncbi.nlm.nih.gov/gene/?term=3798 "D12S1889, MY050, NKHC, SPG10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011897 37998 CG2736 http://www.ncbi.nlm.nih.gov/gene/?term=37998 "Dmel_ Dmel\CG2736, cg2736 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011898 3799 KIF5B http://www.ncbi.nlm.nih.gov/gene/?term=3799 "HEL-S-61, KINH, KNS, KNS1, UKHC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011899 3799 KIF5B http://www.ncbi.nlm.nih.gov/gene/?term=3799 "HEL-S-61, KINH, KNS, KNS1, UKHC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011900 3799 KIF5B http://www.ncbi.nlm.nih.gov/gene/?term=3799 "HEL-S-61, KINH, KNS, KNS1, UKHC " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011901 379 ARL4D http://www.ncbi.nlm.nih.gov/gene/?term=379 "ARF4L, ARL6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011902 37 ACADVL http://www.ncbi.nlm.nih.gov/gene/?term=37 "ACAD6, LCACD, VLCAD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011903 37 ACADVL http://www.ncbi.nlm.nih.gov/gene/?term=37 "ACAD6, LCACD, VLCAD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011904 380031 znf330 http://www.ncbi.nlm.nih.gov/gene/?term=380031 noa36 mRNA Xenopus laevis 21492502 Nucleolus Oocyte In situ hybridization Here we found that XNOA 36 transcript also localises to the nucleoli and in the METRO region. RLID00011905 380031 znf330 http://www.ncbi.nlm.nih.gov/gene/?term=380031 noa36 mRNA Xenopus laevis 21492502 Cytoplasm Oocyte In situ hybridization "Extensive analysis of serial sections of oocytes derived from nine females showed a small amount of the XNOA 36 transcript in the germinal vesicle (GV) and in the mitochondrial cloud (MC), in addition to the major cytoplasmic localisation previously described (Vaccaro et al., 2010). " RLID00011906 380031 znf330 http://www.ncbi.nlm.nih.gov/gene/?term=380031 noa36 mRNA Xenopus laevis 21492502 Mitochondrion Oocyte In situ hybridization "Extensive analysis of serial sections of oocytes derived from nine females showed a small amount of the XNOA 36 transcript in the germinal vesicle (GV) and in the mitochondrial cloud (MC), in addition to the major cytoplasmic localisation previously described (Vaccaro et al., 2010). " RLID00011907 38016 CG13405 http://www.ncbi.nlm.nih.gov/gene/?term=38016 "Dmel_ BcDNA:AT11049, Dmel\CG13405 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011908 38017 Pdk1 http://www.ncbi.nlm.nih.gov/gene/?term=38017 "Dmel_CG1210, 1210, CG1201, CG1210, DSTPK61, Dmel\CG1210, Dstpk61, PDK, PDK-1, PDK1, PDK1/Pk61C, PK61C, Pk61C, Pk61C/PDK1, Pk61C|PDK1, Pk61c/PDK1, dPDK, dPDK-1, dPDK1, dSTPK61, pdk1, pk61c " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011909 38017 Pdk1 http://www.ncbi.nlm.nih.gov/gene/?term=38017 "Dmel_CG1210, 1210, CG1201, CG1210, DSTPK61, Dmel\CG1210, Dstpk61, PDK, PDK-1, PDK1, PDK1/Pk61C, PK61C, Pk61C, Pk61C/PDK1, Pk61C|PDK1, Pk61c/PDK1, dPDK, dPDK-1, dPDK1, dSTPK61, pdk1, pk61c " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011910 3801 KIFC3 http://www.ncbi.nlm.nih.gov/gene/?term=3801 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011911 3801 KIFC3 http://www.ncbi.nlm.nih.gov/gene/?term=3801 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011912 38021 p130CAS http://www.ncbi.nlm.nih.gov/gene/?term=38021 "Dmel_CG1212, CG1212, CT1293, DCas, Dcas, Dmel\CG1212, p130Cas " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011913 380601 Fastkd5 http://www.ncbi.nlm.nih.gov/gene/?term=380601 "C78212, mKIAA1792 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011914 380654 Cfap54 http://www.ncbi.nlm.nih.gov/gene/?term=380654 "4930485B16Rik, Gm872 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011915 380664 Lemd3 http://www.ncbi.nlm.nih.gov/gene/?term=380664 "AI316861, Man1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011916 380686 Cnrip1 http://www.ncbi.nlm.nih.gov/gene/?term=380686 "1500041B16Rik, 3110054C06Rik, 5330437A18Rik, AI854501, C2orf32 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00011917 380730 Gm884 http://www.ncbi.nlm.nih.gov/gene/?term=380730 LRRC37 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011918 38078 MED30 http://www.ncbi.nlm.nih.gov/gene/?term=38078 "Dmel_CG17183, CG17183, Dmel\CG17183, Med11/TRAP25, Med20, Med30, Trap25, dMED20, dTRAP25, med30 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011919 38078 MED30 http://www.ncbi.nlm.nih.gov/gene/?term=38078 "Dmel_CG17183, CG17183, Dmel\CG17183, Med11/TRAP25, Med20, Med30, Trap25, dMED20, dTRAP25, med30 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011920 380845 Gm904 http://www.ncbi.nlm.nih.gov/gene/?term=380845 Gm1135 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011921 38087 CG13895 http://www.ncbi.nlm.nih.gov/gene/?term=38087 Dmel_ Dmel\CG13895 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011922 380921 Dgkh http://www.ncbi.nlm.nih.gov/gene/?term=380921 "5930402B05Rik, D130015C16, DGK " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011923 38093 CG13900 http://www.ncbi.nlm.nih.gov/gene/?term=38093 "Dmel_ Dmel\CG13900, SF3B3 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011924 38093 CG13900 http://www.ncbi.nlm.nih.gov/gene/?term=38093 "Dmel_ Dmel\CG13900, SF3B3 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011925 38093 CG13900 http://www.ncbi.nlm.nih.gov/gene/?term=38093 "Dmel_ Dmel\CG13900, SF3B3 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011926 381045 Ccdc58 http://www.ncbi.nlm.nih.gov/gene/?term=381045 "A930007B11Rik, AI413631 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011927 381045 Ccdc58 http://www.ncbi.nlm.nih.gov/gene/?term=381045 "A930007B11Rik, AI413631 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00011928 381062 Ermard http://www.ncbi.nlm.nih.gov/gene/?term=381062 "2210404J11Rik, 2410011O22Rik, AI448938 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011929 381062 Ermard http://www.ncbi.nlm.nih.gov/gene/?term=381062 "2210404J11Rik, 2410011O22Rik, AI448938 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00011930 381101 Dnph1 http://www.ncbi.nlm.nih.gov/gene/?term=381101 "C76683, Rcl " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011931 381201 Ap5b1 http://www.ncbi.nlm.nih.gov/gene/?term=381201 Gm962 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011932 381201 Ap5b1 http://www.ncbi.nlm.nih.gov/gene/?term=381201 Gm962 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00011933 381236 Lipo1 http://www.ncbi.nlm.nih.gov/gene/?term=381236 AI747699 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011934 381306 BC055324 http://www.ncbi.nlm.nih.gov/gene/?term=381306 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011935 381308 Mnda http://www.ncbi.nlm.nih.gov/gene/?term=381308 "A730048F03, Ifi205b, ifi-205-B " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011936 381314 Iars2 http://www.ncbi.nlm.nih.gov/gene/?term=381314 "2010002H18Rik, C79125 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011937 381319 Batf3 http://www.ncbi.nlm.nih.gov/gene/?term=381319 "9130211I03Rik, Snft " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011938 381337 Fam178b http://www.ncbi.nlm.nih.gov/gene/?term=381337 "1700024G10Rik, Gm990 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011939 381347 4930412O13Rik http://www.ncbi.nlm.nih.gov/gene/?term=381347 "ENSMUSG00000075535, Gm10853 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011940 38137 Sac1 http://www.ncbi.nlm.nih.gov/gene/?term=38137 "Dmel_CG9128, CG9128, Dmel\CG9128, dsac1, l(3)2107, sac1 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011941 381405 Zfp663 http://www.ncbi.nlm.nih.gov/gene/?term=381405 Gm1008 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011942 38149 CG2469 http://www.ncbi.nlm.nih.gov/gene/?term=38149 "Dmel_ Dmel\CG2469, cg2469 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011943 38149 CG2469 http://www.ncbi.nlm.nih.gov/gene/?term=38149 "Dmel_ Dmel\CG2469, cg2469 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011944 381510 Dpy19l4 http://www.ncbi.nlm.nih.gov/gene/?term=381510 "Gm1023, Narg3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011945 381511 Pdp1 http://www.ncbi.nlm.nih.gov/gene/?term=381511 "Gm1024, Ppm2c " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011946 381591 L1td1 http://www.ncbi.nlm.nih.gov/gene/?term=381591 "AA546746, AB211064, D76865, ECAT11 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011947 381598 2610005L07Rik http://www.ncbi.nlm.nih.gov/gene/?term=381598 "2810038F24Rik, 6720476A01Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00011948 3815 KIT http://www.ncbi.nlm.nih.gov/gene/?term=3815 "C-Kit, CD117, PBT, SCFR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011949 38160 Ptp61F http://www.ncbi.nlm.nih.gov/gene/?term=38160 "Dmel_CG9181, BEST:LP01280, CG9178, CG9181, CPtp62A, DCPTP62A, DPTP61F, Dmel\CG9181, PTP1B, PTP61F, Ptp-61F, R-PTP 61F, anon-WO0118547.297, anon-WO0140519.98, dPTP61F, dptp61F, ptp61F " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011950 381654 C87414 http://www.ncbi.nlm.nih.gov/gene/?term=381654 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00011951 38168 rho http://www.ncbi.nlm.nih.gov/gene/?term=38168 "Dmel_CG1004, CG1004, DMRHO, DMRHOa, DMRHOb, DRORHO, Dmel\CG1004, Dmel\rho, Dmrho, RHO, RHOb, Rho, Rho-1, Rho1, Ve, iks-1, rho1, rhom, rhomboid/veinlet, ve, rho " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011952 38168 rho http://www.ncbi.nlm.nih.gov/gene/?term=38168 "Dmel_CG1004, CG1004, DMRHO, DMRHOa, DMRHOb, DRORHO, Dmel\CG1004, Dmel\rho, Dmrho, RHO, RHOb, Rho, Rho-1, Rho1, Ve, iks-1, rho1, rhom, rhomboid/veinlet, ve, rho " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011953 38169 stet http://www.ncbi.nlm.nih.gov/gene/?term=38169 "Dmel_CG33166, B-Rho, Brho, CG12083, CG12504, CG33166, Dmel\CG33166, Rho-2, Rho2, brho, rho-2, rho2 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011954 381759 Wee2 http://www.ncbi.nlm.nih.gov/gene/?term=381759 "Gm1065, Wee1B " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00011955 381760 Ssbp1 http://www.ncbi.nlm.nih.gov/gene/?term=381760 "2810480P10Rik, G630031O20Rik, MtSSB, mtDBP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011956 381778 Igkv16-104 http://www.ncbi.nlm.nih.gov/gene/?term=381778 "Gm1067, rf " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011957 3817 KLK2 http://www.ncbi.nlm.nih.gov/gene/?term=3817 "KLK2A2, hGK-1, hK2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011958 381801 Tatdn2 http://www.ncbi.nlm.nih.gov/gene/?term=381801 "AI646012, mKIAA0218 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00011959 381816 4922502D21Rik http://www.ncbi.nlm.nih.gov/gene/?term=381816 "Clec2m, Gm1074, SPATA78 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011960 381845 Rnf225 http://www.ncbi.nlm.nih.gov/gene/?term=381845 "2310014L17Rik, AV237412, C77118 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011961 38185 CG12004 http://www.ncbi.nlm.nih.gov/gene/?term=38185 "Dmel_ Dmel\CG12004, anon-EST:fe3A8 " mRNA Drosophila melanogaster 25838129 Basal Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011962 3818 KLKB1 http://www.ncbi.nlm.nih.gov/gene/?term=3818 "KLK3, PKK, PKKD, PPK " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011963 381917 Dnah3 http://www.ncbi.nlm.nih.gov/gene/?term=381917 "BC051401, Dnahc3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011964 381979 Brsk1 http://www.ncbi.nlm.nih.gov/gene/?term=381979 "Gm1100, SAD-B, SADB " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011965 381990 Zbtb2 http://www.ncbi.nlm.nih.gov/gene/?term=381990 Gm1103 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00011966 381 ARF5 http://www.ncbi.nlm.nih.gov/gene/?term=381 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011967 381 ARF5 http://www.ncbi.nlm.nih.gov/gene/?term=381 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011968 381 ARF5 http://www.ncbi.nlm.nih.gov/gene/?term=381 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011969 382030 Cnep1r1 http://www.ncbi.nlm.nih.gov/gene/?term=382030 "5033428A16Rik, NEP1-R1, Tmem188 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011970 382038 Urb2 http://www.ncbi.nlm.nih.gov/gene/?term=382038 "C77575, mKIAA0133 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011971 382073 Ccdc84 http://www.ncbi.nlm.nih.gov/gene/?term=382073 "D630044F24Rik, Gm1114 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011972 382074 Foxr1 http://www.ncbi.nlm.nih.gov/gene/?term=382074 "Foxn5, Gm1115 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011973 382090 Cep162 http://www.ncbi.nlm.nih.gov/gene/?term=382090 "4922501C03Rik, mKIAA1009 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011974 382090 Cep162 http://www.ncbi.nlm.nih.gov/gene/?term=382090 "4922501C03Rik, mKIAA1009 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011975 382117 Tcaim http://www.ncbi.nlm.nih.gov/gene/?term=382117 "D9Ertd402e, Gm1129, TOAG-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011976 38223 Cht2 http://www.ncbi.nlm.nih.gov/gene/?term=38223 "Dmel_CG2054, CG2054, CHT2, DmCHT2, Dmel\CG2054, cht2 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011977 382423 Atxn7l3b http://www.ncbi.nlm.nih.gov/gene/?term=382423 "4921506J03Rik, 6230409E21Rik, AI315132, ENSMUSG00000074747 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011978 38246 CG12025 http://www.ncbi.nlm.nih.gov/gene/?term=38246 Dmel_ Dmel\CG12025 mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011979 382620 Tmed8 http://www.ncbi.nlm.nih.gov/gene/?term=382620 "6430595O10Rik, AI447224, Gm1184, Mem1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00011980 382769 Cbx3-ps4 http://www.ncbi.nlm.nih.gov/gene/?term=382769 "EG382769, Gm5196 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00011981 3827 KNG1 http://www.ncbi.nlm.nih.gov/gene/?term=3827 "BDK, BK, KNG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011982 382 ARF6 http://www.ncbi.nlm.nih.gov/gene/?term=382 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011983 382 ARF6 http://www.ncbi.nlm.nih.gov/gene/?term=382 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011984 382 ARF6 http://www.ncbi.nlm.nih.gov/gene/?term=382 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011985 38313 CG1146 http://www.ncbi.nlm.nih.gov/gene/?term=38313 Dmel_ Dmel\CG1146 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011986 3831 KLC1 http://www.ncbi.nlm.nih.gov/gene/?term=3831 "KLC, KNS2, KNS2A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011987 3831 KLC1 http://www.ncbi.nlm.nih.gov/gene/?term=3831 "KLC, KNS2, KNS2A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011988 3832 KIF11 http://www.ncbi.nlm.nih.gov/gene/?term=3832 "EG5, HKSP, KNSL1, MCLMR, TRIP5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011989 3832 KIF11 http://www.ncbi.nlm.nih.gov/gene/?term=3832 "EG5, HKSP, KNSL1, MCLMR, TRIP5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011990 3832 KIF11 http://www.ncbi.nlm.nih.gov/gene/?term=3832 "EG5, HKSP, KNSL1, MCLMR, TRIP5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00011991 3833 KIFC1 http://www.ncbi.nlm.nih.gov/gene/?term=3833 "HSET, KNSL2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011992 3833 KIFC1 http://www.ncbi.nlm.nih.gov/gene/?term=3833 "HSET, KNSL2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011993 383548 Serpinb3b http://www.ncbi.nlm.nih.gov/gene/?term=383548 "Scca2-rs, Scca2-rs1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00011994 3835 KIF22 http://www.ncbi.nlm.nih.gov/gene/?term=3835 "A-328A3.2, KID, KNSL4, OBP, OBP-1, OBP-2, SEMDJL2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011995 3835 KIF22 http://www.ncbi.nlm.nih.gov/gene/?term=3835 "A-328A3.2, KID, KNSL4, OBP, OBP-1, OBP-2, SEMDJL2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011996 38362 scramb2 http://www.ncbi.nlm.nih.gov/gene/?term=38362 "Dmel_CG1893, CG1893, Dmel\CG1893, Scramb2 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00011997 3836 KPNA1 http://www.ncbi.nlm.nih.gov/gene/?term=3836 "IPOA5, NPI-1, RCH2, SRP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00011998 3836 KPNA1 http://www.ncbi.nlm.nih.gov/gene/?term=3836 "IPOA5, NPI-1, RCH2, SRP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00011999 3836 KPNA1 http://www.ncbi.nlm.nih.gov/gene/?term=3836 "IPOA5, NPI-1, RCH2, SRP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012000 38376 BtbVII http://www.ncbi.nlm.nih.gov/gene/?term=38376 "Dmel_CG43365, BTB-VII, BTBVII, BcDNA:GH07729, CG11494, CG14956, CG43365, Dmel\CG43365, Dmel_CG11494, Dmel_CG14956 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012001 3837 KPNB1 http://www.ncbi.nlm.nih.gov/gene/?term=3837 "IMB1, IPO1, IPOB, Impnb, NTF97 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012002 3837 KPNB1 http://www.ncbi.nlm.nih.gov/gene/?term=3837 "IMB1, IPO1, IPOB, Impnb, NTF97 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012003 3837 KPNB1 http://www.ncbi.nlm.nih.gov/gene/?term=3837 "IMB1, IPO1, IPOB, Impnb, NTF97 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012004 3838 KPNA2 http://www.ncbi.nlm.nih.gov/gene/?term=3838 "IPOA1, QIP2, RCH1, SRP1alpha " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012005 3838 KPNA2 http://www.ncbi.nlm.nih.gov/gene/?term=3838 "IPOA1, QIP2, RCH1, SRP1-alpha, SRP1alpha " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012006 3838 KPNA2 http://www.ncbi.nlm.nih.gov/gene/?term=3838 "IPOA1, QIP2, RCH1, SRP1-alpha, SRP1alpha " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012007 3839 KPNA3 http://www.ncbi.nlm.nih.gov/gene/?term=3839 "IPOA4, SRP1, SRP1gamma, SRP4, hSRP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012008 3839 KPNA3 http://www.ncbi.nlm.nih.gov/gene/?term=3839 "IPOA4, SRP1, SRP1gamma, SRP4, hSRP1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012009 3839 KPNA3 http://www.ncbi.nlm.nih.gov/gene/?term=3839 "IPOA4, SRP1, SRP1gamma, SRP4, hSRP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012010 38400 CG17746 http://www.ncbi.nlm.nih.gov/gene/?term=38400 "Dmel_ Cg17746, Dmel\CG17746, PP2C " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012011 384061 Fndc5 http://www.ncbi.nlm.nih.gov/gene/?term=384061 "1500001L03Rik, AI836596, C87088, PeP, Pxp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012012 38407 ZnT63C http://www.ncbi.nlm.nih.gov/gene/?term=38407 "Dmel_CG17723, CG17723, Dmel\CG17723, ZnT1, cg17723, dZnT1, dZnT63C " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012013 3840 KPNA4 http://www.ncbi.nlm.nih.gov/gene/?term=3840 "IPOA3, QIP1, SRP3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012014 384281 Gatc http://www.ncbi.nlm.nih.gov/gene/?term=384281 2010003O18Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00012015 3842 TNPO1 http://www.ncbi.nlm.nih.gov/gene/?term=3842 "IPO2, KPNB2, MIP, MIP1, TRN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012016 3842 TNPO1 http://www.ncbi.nlm.nih.gov/gene/?term=3842 "IPO2, KPNB2, MIP, MIP1, TRN " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012017 3842 TNPO1 http://www.ncbi.nlm.nih.gov/gene/?term=3842 "IPO2, KPNB2, MIP, MIP1, TRN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012018 3843 IPO5 http://www.ncbi.nlm.nih.gov/gene/?term=3843 "IMB3, KPNB3, Pse1, RANBP5, imp5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012019 38446 CG12006 http://www.ncbi.nlm.nih.gov/gene/?term=38446 Dmel_ Dmel\CG12006 mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012020 38446 CG12006 http://www.ncbi.nlm.nih.gov/gene/?term=38446 Dmel_ Dmel\CG12006 mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012021 38446 CG12006 http://www.ncbi.nlm.nih.gov/gene/?term=38446 Dmel_ Dmel\CG12006 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012022 38459 mge http://www.ncbi.nlm.nih.gov/gene/?term=38459 "Dmel_CG14981, BcDNA:LP07226, CG14981, Dmel\CG14981, l(3)63Fc, l(3)SH3 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012023 3845 KRAS http://www.ncbi.nlm.nih.gov/gene/?term=3845 "C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS1, KRAS2, NS, NS3, RALD, RASK2, KRAS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012024 3845 KRAS http://www.ncbi.nlm.nih.gov/gene/?term=3845 "C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS1, KRAS2, NS, NS3, RALD, RASK2, KRAS " mRNA Homo sapiens 16178658 Mitochondrion HDF cell Fluorescence in situ hybridization "Unexpectedly, we found that both K-ras and GAPDH mRNAs colocalize with mitochondria. Extensive control studies are performed, including the use of fluorescence in-situ hybridization (FISH), negative-control beacons, and the detection of colocalization of 28S ribosomal RNA with the rough endoplasmic reticulum (ER), suggesting that the mRNA localization and colocalization patterns observed in our study are true and specific. " RLID00012025 38465 CG10853 http://www.ncbi.nlm.nih.gov/gene/?term=38465 "Dmel_ BcDNA:LP09837, Dmel\CG10853 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012026 384783 Irs2 http://www.ncbi.nlm.nih.gov/gene/?term=384783 Irs-2 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012027 38487 CG14995 http://www.ncbi.nlm.nih.gov/gene/?term=38487 "Dmel_ CT34848, Dmel\CG14995, NEST:bs15f01, NEST:bs17f06, anon-WO0140519.252, bs17f06.y1 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012028 38490 Chd64 http://www.ncbi.nlm.nih.gov/gene/?term=38490 "Dmel_CG14996, CG-14996, CG14996, CT34849, Dmel\CG14996, anon-EST:Liang-1.80, clone 1.80 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012029 38490 Chd64 http://www.ncbi.nlm.nih.gov/gene/?term=38490 "Dmel_CG14996, CG-14996, CG14996, CT34849, Dmel\CG14996, anon-EST:Liang-1.80, clone 1.80 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012030 384 ARG2 http://www.ncbi.nlm.nih.gov/gene/?term=384 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012031 384 ARG2 http://www.ncbi.nlm.nih.gov/gene/?term=384 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012032 384 ARG2 http://www.ncbi.nlm.nih.gov/gene/?term=384 mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00012033 385138 BC061237 http://www.ncbi.nlm.nih.gov/gene/?term=385138 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012034 38513 ImpL2 http://www.ncbi.nlm.nih.gov/gene/?term=38513 "Dmel_CG15009, CG15009, CT34862, Dmel\CG15009, GH28, IMP-L2, IMPL2, Imp-12, Imp-L2, ImpL-2 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012035 38513 ImpL2 http://www.ncbi.nlm.nih.gov/gene/?term=38513 "Dmel_CG15009, CG15009, CT34862, Dmel\CG15009, GH28, IMP-L2, IMPL2, Imp-12, Imp-L2, ImpL-2 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012036 38513 ImpL2 http://www.ncbi.nlm.nih.gov/gene/?term=38513 "Dmel_CG15009, CG15009, CT34862, Dmel\CG15009, GH28, IMP-L2, IMPL2, Imp-12, Imp-L2, ImpL-2 " mRNA Drosophila melanogaster 25838129 Perinuclear Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012037 38520 CG11586 http://www.ncbi.nlm.nih.gov/gene/?term=38520 Dmel_ Dmel\CG11586 mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012038 385211 Gm13235 http://www.ncbi.nlm.nih.gov/gene/?term=385211 OTTMUSG00000011061 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00012039 3852 KRT5 http://www.ncbi.nlm.nih.gov/gene/?term=3852 "CK5, DDD, DDD1, EBS2, K5, KRT5A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012040 385317 4930557A04Rik http://www.ncbi.nlm.nih.gov/gene/?term=385317 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012041 385343 Rhox1 http://www.ncbi.nlm.nih.gov/gene/?term=385343 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012042 3853 KRT6A http://www.ncbi.nlm.nih.gov/gene/?term=3853 "CK-6C, CK-6E, CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D, PC3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012043 38540 slow http://www.ncbi.nlm.nih.gov/gene/?term=38540 "Dmel_CG7447, CG7447, CT22877, Dmel\CG7447, Slow, blr, slomo " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012044 38540 slow http://www.ncbi.nlm.nih.gov/gene/?term=38540 "Dmel_CG7447, CG7447, CT22877, Dmel\CG7447, Slow, blr, slomo " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012045 3854 KRT6B http://www.ncbi.nlm.nih.gov/gene/?term=3854 "CK-6B, CK6B, K6B, KRTL1, PC2, PC4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012046 3855 KRT7 http://www.ncbi.nlm.nih.gov/gene/?term=3855 "CK7, K2C7, K7, SCL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012047 385658 Nxpe3 http://www.ncbi.nlm.nih.gov/gene/?term=385658 "Fam55c, Gm1752, Gm611 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012048 3856 KRT8 http://www.ncbi.nlm.nih.gov/gene/?term=3856 "CARD2, CK-8, CK8, CYK8, K2C8, K8, KO " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012049 3856 KRT8 http://www.ncbi.nlm.nih.gov/gene/?term=3856 "CARD2, CK-8, CK8, CYK8, K2C8, K8, KO " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012050 3856 KRT8 http://www.ncbi.nlm.nih.gov/gene/?term=3856 "CARD2, CK-8, CK8, CYK8, K2C8, K8, KO " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012051 3858 KRT10 http://www.ncbi.nlm.nih.gov/gene/?term=3858 "BCIE, BIE, CK10, EHK, K10, KPP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012052 38599 CHMP2B http://www.ncbi.nlm.nih.gov/gene/?term=38599 "Dmel_CG4618, CG4618, Dmel\CG4618, cg4618 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012053 38599 CHMP2B http://www.ncbi.nlm.nih.gov/gene/?term=38599 "Dmel_CG4618, CG4618, Dmel\CG4618, cg4618 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012054 38605 shep http://www.ncbi.nlm.nih.gov/gene/?term=38605 "Dmel_CG32423, BcDNA:LD40028, BcDNA:RH63980, CG10647, CG10649, CG10668, CG32423, Dmel\CG32423, Shep, alan, alan-shepard, anon-EST:Posey83, anon-WO0118547.198, anon-WO0172774.41, cg10668 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012055 3860 KRT13 http://www.ncbi.nlm.nih.gov/gene/?term=3860 "CK13, K13, WSN2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012056 38612 Cyt-c1 http://www.ncbi.nlm.nih.gov/gene/?term=38612 "Dmel_CG4769, CG4769, CY1, Dmel\CG4769, anon-EST:Posey141 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012057 3861 KRT14 http://www.ncbi.nlm.nih.gov/gene/?term=3861 "CK14, EBS3, EBS4, K14, NFJ " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012058 38639 lin-28 http://www.ncbi.nlm.nih.gov/gene/?term=38639 "Dmel_CG17334, BcDNA:RE05342, CG17334, Dmel\CG17334, EP(3)0915, lin28 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012059 38648 scny http://www.ncbi.nlm.nih.gov/gene/?term=38648 "Dmel_CG5505, 2331, CG5505, Dmel\CG5505, Q9VRP5, Scny, USP36, Usp36, anon-WO0118547.247, dUSP36, dUsp36, et, l(3)02331, mule " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012060 38655 CG5537 http://www.ncbi.nlm.nih.gov/gene/?term=38655 "Dmel_ Dmel\CG5537, anon-EST:Posey275, uprt " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012061 38658 CG5568 http://www.ncbi.nlm.nih.gov/gene/?term=38658 Dmel_ Dmel\CG5568 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012062 386655 Eid2 http://www.ncbi.nlm.nih.gov/gene/?term=386655 "Cri2, EID-2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00012063 38668 Vap-33B http://www.ncbi.nlm.nih.gov/gene/?term=38668 "Dmel_CG33523, BcDNA:GH09028, CG10727, CG10977, CG32410, CG33523, Dmel\CG33523 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012064 38669 Rcc1 http://www.ncbi.nlm.nih.gov/gene/?term=38669 "Dmel_CG10480, BJ1, Bj1, CG10480, CG18640 (Bj1), Dmel\CG10480, RCC1, RanGEF, dRCC1, inxs, sdt " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012065 386701 tubb5 http://www.ncbi.nlm.nih.gov/gene/?term=386701 mRNA Danio rerio 24089481 Axon Embryoneuron Whole mount in situ hybridization "Here, we provide direct evidence of the presence of mRNAs of the tubb5, nefma, and stmnb2 genes in several types of axons in the developing zebrafish (Danio rerio) embryo, with frequent accumulation at the growth cone. We further show that axonal localization of mRNA is a specific property of a subset of genes, as mRNAs of the huc and neurod genes, abundantly expressed in neurons, were not found in axons. " RLID00012066 38697 CG10467 http://www.ncbi.nlm.nih.gov/gene/?term=38697 Dmel_ Dmel\CG10467 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012067 387032 ZKSCAN4 http://www.ncbi.nlm.nih.gov/gene/?term=387032 "P1P373C6, ZNF307, ZNF427, ZSCAN36 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012068 387066 SNHG5 http://www.ncbi.nlm.nih.gov/gene/?term=387066 "C6orf160, LINC00044, NCRNA00044, U50HG, bA33E24.2 " lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012069 38708 Lcp65Ac http://www.ncbi.nlm.nih.gov/gene/?term=38708 "Dmel_CG6956, CG6956, DCP2, DMLCP65c, Dmel\CG6956, LCP65Ac, Lcp-c " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012070 387103 CENPW http://www.ncbi.nlm.nih.gov/gene/?term=387103 "C6orf173, CENP-W, CUG2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012071 387103 CENPW http://www.ncbi.nlm.nih.gov/gene/?term=387103 "C6orf173, CENP-W, CUG2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012072 387263 C6orf120 http://www.ncbi.nlm.nih.gov/gene/?term=387263 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012073 387263 C6orf120 http://www.ncbi.nlm.nih.gov/gene/?term=387263 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012074 3872 KRT17 http://www.ncbi.nlm.nih.gov/gene/?term=3872 "39.1, CK-17, K17, PC, PC2, PCHC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012075 387338 NSUN4 http://www.ncbi.nlm.nih.gov/gene/?term=387338 SHTAP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012076 387338 NSUN4 http://www.ncbi.nlm.nih.gov/gene/?term=387338 SHTAP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012077 387343 Tas2r109 http://www.ncbi.nlm.nih.gov/gene/?term=387343 "T2R09, Tas2r9, mGR09, mt2r62 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012078 387349 Tas2r121 http://www.ncbi.nlm.nih.gov/gene/?term=387349 "T2R21, Tas2r13, Tas2r21, mGR21, mT2r48 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012079 387496 RASL11A http://www.ncbi.nlm.nih.gov/gene/?term=387496 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012080 38756 CG10077 http://www.ncbi.nlm.nih.gov/gene/?term=38756 "Dmel_ BcDNA:HL01868, BcDNA:HL07910, DmRH5, Dmel\CG10077, cg10077, p90 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012081 38756 CG10077 http://www.ncbi.nlm.nih.gov/gene/?term=38756 "Dmel_ BcDNA:HL01868, BcDNA:HL07910, DmRH5, Dmel\CG10077, cg10077, p90 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012082 387590 TPTEP1 http://www.ncbi.nlm.nih.gov/gene/?term=387590 psiTPTE22 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012083 387597 ILDR2 http://www.ncbi.nlm.nih.gov/gene/?term=387597 "C1orf32, dJ782G3.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012084 387597 ILDR2 http://www.ncbi.nlm.nih.gov/gene/?term=387597 "C1orf32, dJ782G3.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012085 3875 KRT18 http://www.ncbi.nlm.nih.gov/gene/?term=3875 "CK-18, CYK18, K18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012086 3875 KRT18 http://www.ncbi.nlm.nih.gov/gene/?term=3875 "CK-18, CYK18, K18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012087 3875 KRT18 http://www.ncbi.nlm.nih.gov/gene/?term=3875 "CK-18, CYK18, K18 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012088 387609 Zhx2 http://www.ncbi.nlm.nih.gov/gene/?term=387609 "Afr-1, Afr1, Raf, mKIAA0854 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012089 38762 Mis12 http://www.ncbi.nlm.nih.gov/gene/?term=38762 "Dmel_CG18156, BcDNA:RE19545, CG18156, Dmel\CG18156, Mis-12, dm " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012090 387640 SKIDA1 http://www.ncbi.nlm.nih.gov/gene/?term=387640 "C10orf140, DLN-1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012091 387640 SKIDA1 http://www.ncbi.nlm.nih.gov/gene/?term=387640 "C10orf140, DLN-1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012092 387644 LINC00202-1 http://www.ncbi.nlm.nih.gov/gene/?term=387644 "C10orf51, LINC00202, NCRNA00202, bB27G4.1 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012093 387733 IFITM5 http://www.ncbi.nlm.nih.gov/gene/?term=387733 "BRIL, DSPA1, Hrmp1, OI5, fragilis4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012094 38774 Cpr65Eb http://www.ncbi.nlm.nih.gov/gene/?term=38774 "Dmel_CG8638, BcDNA:RE28679, CG8638, DmelCpr65Eb, Dmel\CG8638 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012095 387820 LOC387820 http://www.ncbi.nlm.nih.gov/gene/?term=387820 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012096 387882 C12orf75 http://www.ncbi.nlm.nih.gov/gene/?term=387882 "AGD3, OCC-1, OCC1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012097 387893 KMT5A http://www.ncbi.nlm.nih.gov/gene/?term=387893 "PR-Set7, SET07, SET8, SETD8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012098 387914 SHISA2 http://www.ncbi.nlm.nih.gov/gene/?term=387914 "C13orf13, PRO28631, TMEM46, WGAR9166, bA398O19.2, hShisa " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012099 387914 SHISA2 http://www.ncbi.nlm.nih.gov/gene/?term=387914 "C13orf13, PRO28631, TMEM46, WGAR9166, bA398O19.2, hShisa " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012100 387921 NHLRC3 http://www.ncbi.nlm.nih.gov/gene/?term=387921 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012101 387921 NHLRC3 http://www.ncbi.nlm.nih.gov/gene/?term=387921 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012102 387 RHOA http://www.ncbi.nlm.nih.gov/gene/?term=387 "ARH12, ARHA, RHO12, RHOH12 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012103 387 RHOA http://www.ncbi.nlm.nih.gov/gene/?term=387 "ARH12, ARHA, RHO12, RHOH12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012104 387 RHOA http://www.ncbi.nlm.nih.gov/gene/?term=387 "ARH12, ARHA, RHO12, RHOH12 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012105 38808 CG8602 http://www.ncbi.nlm.nih.gov/gene/?term=38808 "Dmel_ Dmel\CG8602, anon-WO0118547.349, anon-WO0118547.382 " mRNA Drosophila melanogaster 25838129 Perinuclear Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012106 3880 KRT19 http://www.ncbi.nlm.nih.gov/gene/?term=3880 "CK19, K19, K1CS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012107 3880 KRT19 http://www.ncbi.nlm.nih.gov/gene/?term=3880 "CK19, K19, K1CS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012108 388115 C15orf52 http://www.ncbi.nlm.nih.gov/gene/?term=388115 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012109 388115 C15orf52 http://www.ncbi.nlm.nih.gov/gene/?term=388115 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012110 38814 CG14834 http://www.ncbi.nlm.nih.gov/gene/?term=38814 "Dmel_ CT34650, Dmel\CG14834 " mRNA Drosophila melanogaster 25838129 Perinuclear Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012111 388327 C17orf100 http://www.ncbi.nlm.nih.gov/gene/?term=388327 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012112 388335 TMEM220 http://www.ncbi.nlm.nih.gov/gene/?term=388335 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012113 388335 TMEM220 http://www.ncbi.nlm.nih.gov/gene/?term=388335 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012114 38842 CG8539 http://www.ncbi.nlm.nih.gov/gene/?term=38842 Dmel_ Dmel\CG8539 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012115 38842 CG8539 http://www.ncbi.nlm.nih.gov/gene/?term=38842 Dmel_ Dmel\CG8539 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012116 38842 CG8539 http://www.ncbi.nlm.nih.gov/gene/?term=38842 Dmel_ Dmel\CG8539 mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012117 38845 ltl http://www.ncbi.nlm.nih.gov/gene/?term=38845 "Dmel_CG32372, CG14836, CG32372, CG7545, CT15760, Dmel\CG32372, F, anon-EST:CL1a11, l(3)tr, lincRNA.S4366 " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00012118 388512 CLEC17A http://www.ncbi.nlm.nih.gov/gene/?term=388512 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012119 388524 RPSAP58 http://www.ncbi.nlm.nih.gov/gene/?term=388524 RPSA_30_1642 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012120 388552 BLOC1S3 http://www.ncbi.nlm.nih.gov/gene/?term=388552 "BLOS3, HPS8, RP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012121 388552 BLOC1S3 http://www.ncbi.nlm.nih.gov/gene/?term=388552 "BLOS3, HPS8, RP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012122 388552 BLOC1S3 http://www.ncbi.nlm.nih.gov/gene/?term=388552 "BLOS3, HPS8, RP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012123 388555 IGFL3 http://www.ncbi.nlm.nih.gov/gene/?term=388555 UNQ483 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012124 3885565 PIP4K http://www.ncbi.nlm.nih.gov/gene/?term=3885565 "Dmel_CG17471, CG17471, Dmel\CG17471, PIP5K 102E, dPIP4K " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012125 3885600 tRNA:N5:42Af http://www.ncbi.nlm.nih.gov/gene/?term=3885600 "Dmel_CR33973, AE002769.trna7-AsnGTT, Asn-tRNA-6, Asn6, CR33973, Dmel\CR33973, chr2R.trna98-AsnGTT, tRNA:N:GTT:AE002769-c, tRNA:asn5:42Af " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011936.html RLID00012126 3885637 CG33993 http://www.ncbi.nlm.nih.gov/gene/?term=3885637 "Dmel_ CG13289, CG13290, Dmel\CG33993 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012127 388564 TMEM238 http://www.ncbi.nlm.nih.gov/gene/?term=388564 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012128 3885657 tRNA:N5:42Ag http://www.ncbi.nlm.nih.gov/gene/?term=3885657 "Dmel_CR33972, AE002769.trna11-AsnGTT, Asn-tRNA-7, Asn7, CR33972, Dmel\CR33972, chr2R.trna2-AsnGTT, tRNA:N:GTT:AE002769-e, tRNA:asn5:42Ag " tRNA Drosophila melanogaster 26467478 Cytosol - FlyBase Data are collected from FlyBase database: http://flybase.org/reports/FBgn0011937.html RLID00012129 388591 RNF207 http://www.ncbi.nlm.nih.gov/gene/?term=388591 C1orf188 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012130 388591 RNF207 http://www.ncbi.nlm.nih.gov/gene/?term=388591 C1orf188 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012131 38864 CG12262 http://www.ncbi.nlm.nih.gov/gene/?term=38864 "Dmel_ ACAD, CG 12262, Dmel\CG12262, MCAD " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012132 388650 FAM69A http://www.ncbi.nlm.nih.gov/gene/?term=388650 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012133 388677 NOTCH2NL http://www.ncbi.nlm.nih.gov/gene/?term=388677 N2N mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012134 388677 NOTCH2NL http://www.ncbi.nlm.nih.gov/gene/?term=388677 N2N mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012135 388743 CAPN8 http://www.ncbi.nlm.nih.gov/gene/?term=388743 nCL-2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012136 388753 COA6 http://www.ncbi.nlm.nih.gov/gene/?term=388753 "C1orf31, CEMCOX4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012137 388753 COA6 http://www.ncbi.nlm.nih.gov/gene/?term=388753 "C1orf31, CEMCOX4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012138 388759 C1orf229 http://www.ncbi.nlm.nih.gov/gene/?term=388759 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012139 388759 C1orf229 http://www.ncbi.nlm.nih.gov/gene/?term=388759 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012140 388789 LINC00493 http://www.ncbi.nlm.nih.gov/gene/?term=388789 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012141 388796 SNHG17 http://www.ncbi.nlm.nih.gov/gene/?term=388796 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012142 388886 LRRC75B http://www.ncbi.nlm.nih.gov/gene/?term=388886 "C22orf36, FAM211B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012143 38888 CG8209 http://www.ncbi.nlm.nih.gov/gene/?term=38888 "Dmel_ Dmel\CG8209, anon-WO0172774.138 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012144 38890 nmo http://www.ncbi.nlm.nih.gov/gene/?term=38890 "Dmel_CG7892, CG7892, Dmel\CG7892, NEMO, NEMO/NLK, NLK, Nemo, Nlk, Nmo, ORE-6, adk, adk1, anon-EST:Gibbs3, anon-EST:Liang-2.43, anon-WO0118547.332, anon-WO0140519.256, anon-WO0172774.138, clone 2.43 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012145 38890 nmo http://www.ncbi.nlm.nih.gov/gene/?term=38890 "Dmel_CG7892, CG7892, Dmel\CG7892, NEMO, NEMO/NLK, NLK, Nemo, Nlk, Nmo, ORE-6, adk, adk1, anon-EST:Gibbs3, anon-EST:Liang-2.43, anon-WO0118547.332, anon-WO0140519.256, anon-WO0172774.138, clone 2.43 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012146 38890 nmo http://www.ncbi.nlm.nih.gov/gene/?term=38890 "Dmel_CG7892, CG7892, Dmel\CG7892, NEMO, NEMO/NLK, NLK, Nemo, Nlk, Nmo, ORE-6, adk, adk1, anon-EST:Gibbs3, anon-EST:Liang-2.43, anon-WO0118547.332, anon-WO0140519.256, anon-WO0172774.138, clone 2.43 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012147 38890 nmo http://www.ncbi.nlm.nih.gov/gene/?term=38890 "Dmel_CG7892, CG7892, Dmel\CG7892, NEMO, NEMO/NLK, NLK, Nemo, Nlk, Nmo, ORE-6, adk, adk1, anon-EST:Gibbs3, anon-EST:Liang-2.43, anon-WO0118547.332, anon-WO0140519.256, anon-WO0172774.138, clone 2.43 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012148 388931 MFSD2B http://www.ncbi.nlm.nih.gov/gene/?term=388931 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012149 388931 MFSD2B http://www.ncbi.nlm.nih.gov/gene/?term=388931 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012150 388951 TSPYL6 http://www.ncbi.nlm.nih.gov/gene/?term=388951 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012151 38895 Ect4 http://www.ncbi.nlm.nih.gov/gene/?term=38895 "Dmel_CG43119, CG13680, CG13681, CG34373, CG43119, CG7905, CG7915, Dmel\CG43119, Dmel_CG13680, Dmel_CG13681, Dmel_CG34373, Dmel_CG7915/SARM, anon-WO0118547.272, dsarm, ect4, Ect4 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012152 38895 Ect4 http://www.ncbi.nlm.nih.gov/gene/?term=38895 "Dmel_CG43119, CG13680, CG13681, CG34373, CG43119, CG7905, CG7915, Dmel\CG43119, Dmel_CG13680, Dmel_CG13681, Dmel_CG34373, Dmel_CG7915/SARM, anon-WO0118547.272, dsarm, ect4, Ect4 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012153 388962 BOLA3 http://www.ncbi.nlm.nih.gov/gene/?term=388962 MMDS2 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012154 388969 C2orf68 http://www.ncbi.nlm.nih.gov/gene/?term=388969 HCRCN81 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012155 388969 C2orf68 http://www.ncbi.nlm.nih.gov/gene/?term=388969 HCRCN81 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012156 388 RHOB http://www.ncbi.nlm.nih.gov/gene/?term=388 "ARH6, ARHB, MST081, MSTP081, RHOH6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012157 388 RHOB http://www.ncbi.nlm.nih.gov/gene/?term=388 "ARH6, ARHB, MST081, MSTP081, RHOH6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012158 38900 ldbr http://www.ncbi.nlm.nih.gov/gene/?term=38900 "Dmel_CG7942, CG7942, Dmel\CG7942, Lbdr, Ldbr " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012159 38900 ldbr http://www.ncbi.nlm.nih.gov/gene/?term=38900 "Dmel_CG7942, CG7942, Dmel\CG7942, Lbdr, Ldbr " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012160 38905 mus301 http://www.ncbi.nlm.nih.gov/gene/?term=38905 "Dmel_CG7972, CG7972, Dmel\CG7972, Mus301, SpnC, anon-WO0118547.354, cg7972, mus(3)301, spn-C, spnC " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012161 389114 ZNF662 http://www.ncbi.nlm.nih.gov/gene/?term=389114 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012162 389114 ZNF662 http://www.ncbi.nlm.nih.gov/gene/?term=389114 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012163 389136 VGLL3 http://www.ncbi.nlm.nih.gov/gene/?term=389136 "VGL-3, VGL3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012164 389136 VGLL3 http://www.ncbi.nlm.nih.gov/gene/?term=389136 "VGL-3, VGL3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012165 3891 KRT85 http://www.ncbi.nlm.nih.gov/gene/?term=3891 "ECTD4, HB5, Hb-5, K85, KRTHB5, hHb5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012166 389203 SMIM20 http://www.ncbi.nlm.nih.gov/gene/?term=389203 C4orf52 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012167 389337 ARHGEF37 http://www.ncbi.nlm.nih.gov/gene/?term=389337 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012168 389362 PSMG4 http://www.ncbi.nlm.nih.gov/gene/?term=389362 "C6orf86, PAC4, bA506K6.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012169 389362 PSMG4 http://www.ncbi.nlm.nih.gov/gene/?term=389362 "C6orf86, PAC4, bA506K6.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012170 389400 GFRAL http://www.ncbi.nlm.nih.gov/gene/?term=389400 "C6orf144, GRAL, UNQ9356, bA360D14.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012171 389400 GFRAL http://www.ncbi.nlm.nih.gov/gene/?term=389400 "C6orf144, GRAL, UNQ9356, bA360D14.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012172 389432 SAMD5 http://www.ncbi.nlm.nih.gov/gene/?term=389432 dJ875H10.1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012173 38944 CG7182 http://www.ncbi.nlm.nih.gov/gene/?term=38944 Dmel_ Dmel\CG7182 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012174 389524 GTF2IRD2B http://www.ncbi.nlm.nih.gov/gene/?term=389524 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012175 389524 GTF2IRD2B http://www.ncbi.nlm.nih.gov/gene/?term=389524 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012176 389541 LAMTOR4 http://www.ncbi.nlm.nih.gov/gene/?term=389541 C7orf59 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012177 389541 LAMTOR4 http://www.ncbi.nlm.nih.gov/gene/?term=389541 C7orf59 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012178 38958 mtrm http://www.ncbi.nlm.nih.gov/gene/?term=38958 "Dmel_CG18543, CG18543, D52, Dmel\CG18543, anon-D52, anonD52 " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012179 3895 KTN1 http://www.ncbi.nlm.nih.gov/gene/?term=3895 "CG1, KNT, MU-RMS-40.19 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012180 3895 KTN1 http://www.ncbi.nlm.nih.gov/gene/?term=3895 "CG1, KNT, MU-RMS-40.19 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012181 3895 KTN1 http://www.ncbi.nlm.nih.gov/gene/?term=3895 "CG1, KNT, MU-RMS-40.19 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012182 3895 KTN1 http://www.ncbi.nlm.nih.gov/gene/?term=3895 "CG1, KNT, MU-RMS-40.19 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012183 3895 KTN1 http://www.ncbi.nlm.nih.gov/gene/?term=3895 "CG1, KNT, MU-RMS-40.19 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012184 389610 XKR5 http://www.ncbi.nlm.nih.gov/gene/?term=389610 "HARL2754, UNQ2754, XRG5A, XRG5BM " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012185 389610 XKR5 http://www.ncbi.nlm.nih.gov/gene/?term=389610 "HARL2754, UNQ2754, XRG5A, XRG5BM " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012186 389641 LOC389641 http://www.ncbi.nlm.nih.gov/gene/?term=389641 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012187 389643 NUGGC http://www.ncbi.nlm.nih.gov/gene/?term=389643 "C8orf80, HMFN0672, SLIP-GC " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012188 389643 NUGGC http://www.ncbi.nlm.nih.gov/gene/?term=389643 "C8orf80, HMFN0672, SLIP-GC " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012189 389677 RBM12B http://www.ncbi.nlm.nih.gov/gene/?term=389677 MGC:33837 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012190 389812 LCN15 http://www.ncbi.nlm.nih.gov/gene/?term=389812 "PRO6093, UNQ2541 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012191 389834 LOC389834 http://www.ncbi.nlm.nih.gov/gene/?term=389834 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012192 389834 LOC389834 http://www.ncbi.nlm.nih.gov/gene/?term=389834 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012193 389840 MAP3K15 http://www.ncbi.nlm.nih.gov/gene/?term=389840 "ASK3, bA723P2.3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012194 389840 MAP3K15 http://www.ncbi.nlm.nih.gov/gene/?term=389840 "ASK3, bA723P2.3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012195 3898 LAD1 http://www.ncbi.nlm.nih.gov/gene/?term=3898 LadA mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012196 3898 LAD1 http://www.ncbi.nlm.nih.gov/gene/?term=3898 LadA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012197 389906 LOC389906 http://www.ncbi.nlm.nih.gov/gene/?term=389906 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012198 38995 h http://www.ncbi.nlm.nih.gov/gene/?term=38995 "Dmel_CG6494, 8247, CG6494, Dmel\CG6494, H, HRY, Hairy, bHLHb39, bHLHc14, brr, dDr1ry, l(3)08247, l(3)rM384, h " mRNA Drosophila melanogaster 15280214 Basal Embryo In situ hybridization "Whereas embryos laid by wild-type mothers have an almost exclusively apical distribution of pair-rule mRNAs such as eve, ftz, h and runt (run), those laid by egl3e/eglWU50 mothers accumulate a large proportion of these transcripts in the basal cytoplasm (Fig. 5A). " RLID00012199 38995 h http://www.ncbi.nlm.nih.gov/gene/?term=38995 "Dmel_CG6494, 8247, CG6494, Dmel\CG6494, H, HRY, Hairy, bHLHb39, bHLHc14, brr, dDr1ry, l(3)08247, l(3)rM384, h " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012200 3899 AFF3 http://www.ncbi.nlm.nih.gov/gene/?term=3899 "LAF4, MLLT2-like " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012201 3899 AFF3 http://www.ncbi.nlm.nih.gov/gene/?term=3899 "LAF4, MLLT2-like " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012202 3899 AFF3 http://www.ncbi.nlm.nih.gov/gene/?term=3899 "LAF4, MLLT2-like " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012203 389 RHOC http://www.ncbi.nlm.nih.gov/gene/?term=389 "ARH9, ARHC, H9, RHOH9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012204 389 RHOC http://www.ncbi.nlm.nih.gov/gene/?term=389 "ARH9, ARHC, H9, RHOH9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012205 389 RHOC http://www.ncbi.nlm.nih.gov/gene/?term=389 "ARH9, ARHC, H9, RHOH9 " mRNA Homo sapiens 25624724 Cytoplasm Esophageal squamous cell In situ hybridization "RhoC mRNA expression was mainly located within the cytoplasm of the tumor cells, appearing as blue to purple particles by in situ hybridization. " RLID00012206 38 ACAT1 http://www.ncbi.nlm.nih.gov/gene/?term=38 "ACAT, MAT, T2, THIL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012207 390110 ACCSL http://www.ncbi.nlm.nih.gov/gene/?term=390110 mRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00012208 39018 orb2 http://www.ncbi.nlm.nih.gov/gene/?term=39018 "Dmel_CG43782, CG43113, CG43782, CG5735, Dmel\CG43782, Dmel_CG43113, Dmel_CG5735, Dmel_CG5741, Orb2, anon-WO0140519.222, cg5735 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012209 39034 smg http://www.ncbi.nlm.nih.gov/gene/?term=39034 "Dmel_CG5263, CG5263, D69, Dmel\CG5263, SMG, Smg, anon-D69, anonD69 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012210 3903 LAIR1 http://www.ncbi.nlm.nih.gov/gene/?term=3903 "CD305, LAIR-1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012211 3903 LAIR1 http://www.ncbi.nlm.nih.gov/gene/?term=3903 "CD305, LAIR-1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012212 39041 Argk http://www.ncbi.nlm.nih.gov/gene/?term=39041 "Dmel_CG32031, AK, AK-1, ARK, ArgK, CG32031, CG4929, CG5173, Dmel\CG32031, argK, argk " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012213 39085 aay http://www.ncbi.nlm.nih.gov/gene/?term=39085 "Dmel_CG3705, 0423/14, 24661601, CG3705, Dmel\CG3705, anon-WO0172774.117 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012214 390916 NUDT19 http://www.ncbi.nlm.nih.gov/gene/?term=390916 RP2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012215 390916 NUDT19 http://www.ncbi.nlm.nih.gov/gene/?term=390916 RP2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012216 390916 NUDT19 http://www.ncbi.nlm.nih.gov/gene/?term=390916 RP2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012217 39091 Nf-YA http://www.ncbi.nlm.nih.gov/gene/?term=39091 "Dmel_CG3891, CG3891, Dmel\CG3891, NF-YA, dNF-YA " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012218 390927 ZNF793 http://www.ncbi.nlm.nih.gov/gene/?term=390927 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012219 390927 ZNF793 http://www.ncbi.nlm.nih.gov/gene/?term=390927 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012220 3909 LAMA3 http://www.ncbi.nlm.nih.gov/gene/?term=3909 "BM600, E170, LAMNA, LOCS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012221 390 RND3 http://www.ncbi.nlm.nih.gov/gene/?term=390 "ARHE, Rho8, RhoE, memB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012222 390 RND3 http://www.ncbi.nlm.nih.gov/gene/?term=390 "ARHE, Rho8, RhoE, memB " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012223 391059 FRRS1 http://www.ncbi.nlm.nih.gov/gene/?term=391059 "SDFR2, SDR2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012224 391059 FRRS1 http://www.ncbi.nlm.nih.gov/gene/?term=391059 "SDFR2, SDR2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012225 39106 path http://www.ncbi.nlm.nih.gov/gene/?term=39106 "Dmel_CG3424, CG3424, Dmel\CG3424, Path, anon-WO0118547.271, anon-WO0118547.370, pth " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012226 39106 path http://www.ncbi.nlm.nih.gov/gene/?term=39106 "Dmel_CG3424, CG3424, Dmel\CG3424, Path, anon-WO0118547.271, anon-WO0118547.370, pth " mRNA Drosophila melanogaster 25838129 Perinuclear Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012227 3910 LAMA4 http://www.ncbi.nlm.nih.gov/gene/?term=3910 "CMD1JJ, LAMA3*-1, LAMA4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012228 39111 CG42673 http://www.ncbi.nlm.nih.gov/gene/?term=39111 "Dmel_ BcDNA:RE71517, BcDNA:RE71585, CG14178, CG17357, CG3179, CG32048, CG34272, Dm_3L:44995, Dmel\CG42673, Dmel_CG32048, Dmel_CG34272 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012229 3911 LAMA5 http://www.ncbi.nlm.nih.gov/gene/?term=3911 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012230 3912 LAMB1 http://www.ncbi.nlm.nih.gov/gene/?term=3912 "CLM, LIS5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012231 3912 LAMB1 http://www.ncbi.nlm.nih.gov/gene/?term=3912 "CLM, LIS5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012232 3912 LAMB1 http://www.ncbi.nlm.nih.gov/gene/?term=3912 "CLM, LIS5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012233 391356 PTRHD1 http://www.ncbi.nlm.nih.gov/gene/?term=391356 C2orf79 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012234 391358 TRMT112P6 http://www.ncbi.nlm.nih.gov/gene/?term=391358 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012235 3913 LAMB2 http://www.ncbi.nlm.nih.gov/gene/?term=3913 "LAMS, NPHS5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012236 3913 LAMB2 http://www.ncbi.nlm.nih.gov/gene/?term=3913 "LAMS, NPHS5 " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00012237 39145 CG42268 http://www.ncbi.nlm.nih.gov/gene/?term=39145 "Dmel_ CG14170, CG32044, CG32046, CG6740, Dmel\CG42268, Dmel_CG32044, Dmel_CG32046 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012238 3915 LAMC1 http://www.ncbi.nlm.nih.gov/gene/?term=3915 LAMB2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012239 39169 nudE http://www.ncbi.nlm.nih.gov/gene/?term=39169 "Dmel_CG8104, CG8104, Dmel\CG8104, D NudE " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012240 3916 LAMP1 http://www.ncbi.nlm.nih.gov/gene/?term=3916 "CD107a, LAMPA, LGP120 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012241 3916 LAMP1 http://www.ncbi.nlm.nih.gov/gene/?term=3916 "CD107a, LAMPA, LGP120 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012242 3916 LAMP1 http://www.ncbi.nlm.nih.gov/gene/?term=3916 "CD107a, LAMPA, LGP120 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012243 391712 TRIM61 http://www.ncbi.nlm.nih.gov/gene/?term=391712 RNF35 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012244 391 RHOG http://www.ncbi.nlm.nih.gov/gene/?term=391 ARHG mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012245 391 RHOG http://www.ncbi.nlm.nih.gov/gene/?term=391 ARHG mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012246 3920 LAMP2 http://www.ncbi.nlm.nih.gov/gene/?term=3920 "CD107b, LAMP-2, LAMPB, LGP110 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012247 3920 LAMP2 http://www.ncbi.nlm.nih.gov/gene/?term=3920 "CD107b, LAMP-2, LAMPB, LGP110 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012248 3921 RPSA http://www.ncbi.nlm.nih.gov/gene/?term=3921 "37LRP, 67LR, ICAS, LAMBR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, SA, lamR, p40 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012249 3921 RPSA http://www.ncbi.nlm.nih.gov/gene/?term=3921 "37LRP, 67LR, ICAS, LAMBR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, SA, lamR, p40 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012250 3921 RPSA http://www.ncbi.nlm.nih.gov/gene/?term=3921 "37LRP, 67LR, ICAS, LAMBR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, SA, lamR, p40 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012251 3921 RPSA http://www.ncbi.nlm.nih.gov/gene/?term=3921 "37LRP, 67LR, ICAS, LAMBR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, SA, lamR, p40 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012252 3921 RPSA http://www.ncbi.nlm.nih.gov/gene/?term=3921 "37LRP, 67LR, ICAS, LAMBR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, SA, lamR, p40 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012253 39231 CG43693 http://www.ncbi.nlm.nih.gov/gene/?term=39231 "Dmel_ CG34239, CG6327, Dmel\CG43693, Dmel_CG34239, Dmel_CG6327 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012254 39255 NaPi-III http://www.ncbi.nlm.nih.gov/gene/?term=39255 "Dmel_CG42575, CG42575, CG7628, CR32078, Dmel\CG42575, Dmel_CG7628, Dmel_CR32078, Dromel_CG7628_FBtr0076213_mORF, dPit " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012255 3925 STMN1 http://www.ncbi.nlm.nih.gov/gene/?term=3925 "C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012256 3925 STMN1 http://www.ncbi.nlm.nih.gov/gene/?term=3925 "C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012257 3925 STMN1 http://www.ncbi.nlm.nih.gov/gene/?term=3925 "C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012258 39268 CG42671 http://www.ncbi.nlm.nih.gov/gene/?term=39268 "Dmel_ CG18490, CG34240, Dmel\CG42671, Dmel_CG18490, Dmel_CG34240 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012259 3927 LASP1 http://www.ncbi.nlm.nih.gov/gene/?term=3927 "Lasp-1, MLN50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012260 3927 LASP1 http://www.ncbi.nlm.nih.gov/gene/?term=3927 "Lasp-1, MLN50 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012261 3927 LASP1 http://www.ncbi.nlm.nih.gov/gene/?term=3927 "Lasp-1, MLN50 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012262 39284 chrb http://www.ncbi.nlm.nih.gov/gene/?term=39284 "Dmel_CG7533, BcDNA:GH09771, CG7533, Dmel\CG7533, EP(3)1035, anon-EST:Liang-2.51, char, clone 2.51 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012263 392 ARHGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=392 "CDC42GAP, RHOGAP, RHOGAP1, p50rhoGAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012264 392 ARHGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=392 "CDC42GAP, RHOGAP, RHOGAP1, p50rhoGAP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012265 392 ARHGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=392 "CDC42GAP, RHOGAP, RHOGAP1, p50rhoGAP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012266 39309 RIOK1 http://www.ncbi.nlm.nih.gov/gene/?term=39309 "Dmel_CG11660, CG11660, Dmel\CG11660, Rio1, dRIOK1 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012267 3930 LBR http://www.ncbi.nlm.nih.gov/gene/?term=3930 "DHCR14B, LMN2R, PHA, TDRD18 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012268 3930 LBR http://www.ncbi.nlm.nih.gov/gene/?term=3930 "DHCR14B, LMN2R, PHA, TDRD18 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012269 39329 Pi3K68D http://www.ncbi.nlm.nih.gov/gene/?term=39329 "Dmel_CG11621, 11621, BcDNA:LD15217, CG11621, Cpk, Dmel\CG11621, PI(3)K, PI3K, PI3K 68D, PI3K 68_D, PI3K-68D, PI3K-68D/E, PI3K68D, PI3K_68D, PI[[3]]K, Pi3K, cpk, dPI3K, dPIK, pi3k68d " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012270 3932 LCK http://www.ncbi.nlm.nih.gov/gene/?term=3932 "IMD22, LSK, YT16, p56lck, pp58lck " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012271 39332 Klp68D http://www.ncbi.nlm.nih.gov/gene/?term=39332 "Dmel_CG7293, CG7293, DmKlp68D, Dmel\CG7293, KIF 3B, KIF3B, KLP-5, KLP5, KLP68D, KLP68Ddm, KLP[[64D/68D]], Klp5, klp68d " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012272 39340 CycA http://www.ncbi.nlm.nih.gov/gene/?term=39340 "Dmel_CG5940, 0033/02, 0040/24, 0046/23, 0104/07, 0245/34, 0521/06, 0545/13, 1329/16, 1449/05, CG5940, CLD3, CYCA, Cyc A, DmcycA, Dmel\CG5940, S(rux)3B, anon-WO0140519.128, cycA, dCycA, hari, l(3)03946, l(3)183, l(3)68Ea, l(3)j3C8, l(3)neo114, l(3)rsg11, rsg11 " mRNA Drosophila melanogaster 17923096 Posterior Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00012273 3934 LCN2 http://www.ncbi.nlm.nih.gov/gene/?term=3934 "24p3, MSFI, NGAL, p25 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012274 3934 LCN2 http://www.ncbi.nlm.nih.gov/gene/?term=3934 "24p3, MSFI, NGAL, p25 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012275 39368 rols http://www.ncbi.nlm.nih.gov/gene/?term=39368 "Dmel_CG32096, ANTS, Ants, CG12277, CG17155, CG32096, CG5679, Dmel\CG32096, Rol/Ants, Rols, Rols6, Rols7, anon-WO0257455.19, ants, ants/rols, l(3)08232, l(3)68Fd, l(3)j2A6\ants, rols " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012276 39368 rols http://www.ncbi.nlm.nih.gov/gene/?term=39368 "Dmel_CG32096, ANTS, Ants, CG12277, CG17155, CG32096, CG5679, Dmel\CG32096, Rol/Ants, Rols, Rols6, Rols7, anon-WO0257455.19, ants, ants/rols, l(3)08232, l(3)68Fd, l(3)j2A6\ants, rols " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012277 3936 LCP1 http://www.ncbi.nlm.nih.gov/gene/?term=3936 "CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012278 3936 LCP1 http://www.ncbi.nlm.nih.gov/gene/?term=3936 "CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012279 39385 RhoGAP68F http://www.ncbi.nlm.nih.gov/gene/?term=39385 "Dmel_CG6811, CG 6811, CG6811, Dmel\CG6811, RhoGAP " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012280 3939 LDHA http://www.ncbi.nlm.nih.gov/gene/?term=3939 "GSD11, HEL-S-133P, LDHM, PIG19 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012281 3939 LDHA http://www.ncbi.nlm.nih.gov/gene/?term=3939 "GSD11, HEL-S-133P, LDHM, PIG19 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00012282 3939 LDHA http://www.ncbi.nlm.nih.gov/gene/?term=3939 "GSD11, HEL-S-133P, LDHM, PIG19 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012283 3939 LDHA http://www.ncbi.nlm.nih.gov/gene/?term=3939 "GSD11, HEL-S-133P, LDHM, PIG19 " mRNA Homo sapiens 12923260 Ribosome T-cell line Jurkat S1 nuclease protection assays "However, and as depicted in Figure 4 (Cytosol), mRNAs encoding GAPDH and LDH were present in both free and membrane-bound polysomes, and mRNAs encoding Hsp90 displayed a high enrichment in the membrane-bound fraction (75%-97%). Such partitioning of mRNAs to the ER was observed in 15 independent experiments using ER derived from Jurkat and J558 cells alike, thus confirming that mRNAs encoding signal-sequence-bearing proteins and mRNAs encoding cytosolic proteins are present on the ER. " RLID00012284 3939 LDHA http://www.ncbi.nlm.nih.gov/gene/?term=3939 "GSD11, HEL-S-133P, LDHM, PIG19 " mRNA Homo sapiens 18192611 Ribosome HeLa cell Northern blot FIGURE 2. Subcellular mRNA distribution in SRP54 knock-down HeLa cell lines. (A) Total RNA from control HeLa (H) or SRP54 (54) stable knock-down cells was analyzed by Northern blot. (B) Cell surface expression of DR4 was determined by flow cytometry using no primary antibody (control) or DR4 antibody. (C) Cells were fractionated by sequential detergent extraction into cytosol (lane C) or membrane-bound (lane M) fractions. RNA isolated from total cells (lane T) or cell fractions was analyzed by Northern blot using the probes listed in Materials and Methods. Data are collected from Figure 2. RLID00012285 3939 LDHA http://www.ncbi.nlm.nih.gov/gene/?term=3939 "GSD11, HEL-S-133P, LDHM, PIG19 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012286 393 ARHGAP4 http://www.ncbi.nlm.nih.gov/gene/?term=393 "C1, RGC1, RhoGAP4, SrGAP4, p115 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012287 393 ARHGAP4 http://www.ncbi.nlm.nih.gov/gene/?term=393 "C1, RGC1, RhoGAP4, SrGAP4, p115 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012288 39403 CG4300 http://www.ncbi.nlm.nih.gov/gene/?term=39403 "Dmel_ Dmel\CG4300, anon-WO0118547.387 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012289 39406 CG32105 http://www.ncbi.nlm.nih.gov/gene/?term=39406 "Dmel_ CG10432, CG17615, Dmel\CG32105 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012290 39410 Ncc69 http://www.ncbi.nlm.nih.gov/gene/?term=39410 "Dmel_CG4357, BEST:CK01027, CG43567, CG4357, CK01027, Dmel\CG4357, NCC69, NKCC, mdcds_25302 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012291 394263 MUC21 http://www.ncbi.nlm.nih.gov/gene/?term=394263 "C6orf205, KMQK697, MUC-21 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012292 394273 pgat http://www.ncbi.nlm.nih.gov/gene/?term=394273 "pat, xpat-A " mRNA Xenopus laevis 9622619 Germ plasm Oocyte In situ hybridization One of the novel clones isolated had an RNA expression pattern consistent with it being a component of germ plasm and it was thus named Xpat (Xenopus primordial germ cell associated transcript). RLID00012293 394273 pgat http://www.ncbi.nlm.nih.gov/gene/?term=394273 "pat, xpat-A " mRNA Xenopus laevis 11784096 Germ plasm Oocyte In situ hybridization "The germ plasm is a specialized region of oocyte cytoplasm that contains determinants of germ cell fate. In Xenopus oocytes, the germ plasm is a part of the METRO region of mitochondrial cloud. It contains the germinal granules and a variety of coding and noncoding RNAs that include Xcat2, Xlsirts, Xdazl, DEADSouth, Xpat, Xwnt11, fatVg, B7/Fingers, C10/XFACS, and mitochondrial large and small rRNA. We analyzed the distribution of these 11 different RNAs within the various compartments of germ plasm during Xenopus oogenesis and development by using whole-mount electron microscopy in situ hybridization. " RLID00012294 394273 pgat http://www.ncbi.nlm.nih.gov/gene/?term=394273 "pat, xpat-A " mRNA Xenopus laevis 12401170 Vegetal Oocyte In situ hybridization "Figure 2. In Situ Hybridization of Newly Discovered Localized mRNAs In situ hybridization to Xcat-2 mRNA and Xpat mRNAs demonstrates examples of RNAs that localize via the early pathway. Note that most of the RNA is associated with the mitochondrial cloud in stage I oocytes, with little background in the rest of the cytoplasm. By stage II, these RNAs have migrated with the cloud to the vegetal cortex, and there is no detectable RNA in the remaining cytoplasm. " RLID00012295 394292 efnb1 http://www.ncbi.nlm.nih.gov/gene/?term=394292 "LERK-2, cfnd, cfns, efl3-A, ephrinB1, eplg2, lerk2, efnb1 " mRNA Xenopus laevis 12401170 Vegetal Oocyte In situ hybridization "Xlerk, which was identified by computational screening of Xenopus 3'UTRs for highly significant clusters of CAC-containing motifs, follows the intermediate pathway in which localization to the cloud of stage I oocytes is clearly visible but there is also a high level of signal in the remaining cytoplasm. During stage II, labeling is observed both in the cloud at the cortex and in the remaining cytoplasm.. However, by stage III, no cytoplasmic labeling is detected, and all Xlerk RNA is localized to the vegetal pole. By stage IV, this labeling pattern is broader than that of either Xcat-2 or Xpat. " RLID00012296 394292 efnb1 http://www.ncbi.nlm.nih.gov/gene/?term=394292 "LERK-2, cfnd, cfns, efl3-A, ephrinB1, eplg2, lerk2, efnb1 " mRNA Xenopus laevis 12401170 Cytoplasm Oocyte In situ hybridization "Xlerk, which was identified by computational screening of Xenopus 3'UTRs for highly significant clusters of CAC-containing motifs, follows the intermediate pathway in which localization to the cloud of stage I oocytes is clearly visible but there is also a high level of signal in the remaining cytoplasm. During stage II, labeling is observed both in the cloud at the cortex and in the remaining cytoplasm.. However, by stage III, no cytoplasmic labeling is detected, and all Xlerk RNA is localized to the vegetal pole. By stage IV, this labeling pattern is broader than that of either Xcat-2 or Xpat. " RLID00012297 394326 otx1 http://www.ncbi.nlm.nih.gov/gene/?term=394326 "otx1-A, xotx1 " mRNA Xenopus laevis 10585568 Mitochondrion Oocyte In situ hybridization "Xotx1 is a Xenopus homeobox gene related to the Drosophila gene orthodenticle (otd). We previously reported that Xotx1 transcripts are already present in unfertilized egg. Here we report that maternal Xotx1 mRNA is vegetally localized during oogenesis. In stage II oocytes Xotx1 transcripts are localized within the mitochondrial cloud, in a perinuclear position; later on, they are translocated to the vegetal cortex within the mitochondrial cloud. " RLID00012298 394326 otx1 http://www.ncbi.nlm.nih.gov/gene/?term=394326 "otx1-A, xotx1 " mRNA Xenopus laevis 10585568 Vegetal Oocyte In situ hybridization "Xotx1 is a Xenopus homeobox gene related to the Drosophila gene orthodenticle (otd). We previously reported that Xotx1 transcripts are already present in unfertilized egg. Here we report that maternal Xotx1 mRNA is vegetally localized during oogenesis. In stage II oocytes Xotx1 transcripts are localized within the mitochondrial cloud, in a perinuclear position; later on, they are translocated to the vegetal cortex within the mitochondrial cloud. " RLID00012299 39434 nst http://www.ncbi.nlm.nih.gov/gene/?term=39434 "Dmel_CG10627, CG10627, Dmel\CG10627 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012300 39439 ara http://www.ncbi.nlm.nih.gov/gene/?term=39439 "Dmel_CG10571, Ara, CG10571, Dmel\CG10571, IRO-C, Iro, Iro-C, IroC, iro, iro-C " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012301 39439 ara http://www.ncbi.nlm.nih.gov/gene/?term=39439 "Dmel_CG10571, Ara, CG10571, Dmel\CG10571, IRO-C, Iro, Iro-C, IroC, iro, iro-C " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012302 394451 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=394451 "Xcat-2, nos1, xcat2, xnos1 " mRNA Xenopus tropicalis 14745962 Vegetal Oocyte In situ hybridization "To further address this, we examined the spatial expression of Xtcat-2 mRNA. Initially, Xtcat-2 mRNA was expressed at the vegetal pole after fertilization. The cytoplasmic islands expressing Xtcat-2 mRNA were localized at the vegetal cortical region where Xcat-2 mRNA and germ plasm were also localized (Fig. 5A,H). " RLID00012303 394451 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=394451 "Xcat-2, nos1, xcat2, xnos1 " mRNA Xenopus tropicalis 14745962 Vegetal Oocyte In situ hybridization "Initially, Xtcat-2 mRNA was expressed at the vegetal pole after fertilization. The cytoplasmic islands expressing Xtcat-2 mRNA were localized at the vegetal cortical region where Xcat-2 mRNA and germ plasm were also localized (Fig. 5A,H). " RLID00012304 394451 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=394451 "Xcat-2, nos1, xcat2, xnos1 " mRNA Xenopus tropicalis 14745962 Germ plasm Oocyte In situ hybridization "To further address this, we examined the spatial expression of Xtcat-2 mRNA. Initially, Xtcat-2 mRNA was expressed at the vegetal pole after fertilization. The cytoplasmic islands expressing Xtcat-2 mRNA were localized at the vegetal cortical region where Xcat-2 mRNA and germ plasm were also localized (Fig. 5A,H). " RLID00012305 394452 vegt http://www.ncbi.nlm.nih.gov/gene/394452 "Apod, antipodean, brat, tVegT, xombi " mRNA Xenopus laevis 12142022 Vegetal Embryo In situ hybridization The 1280-nt 3'UTR of VegT was found to direct localization to the vegetal cortex in oocytes after injection (Fig. 1A).FIG. 1. RLID00012306 3945 LDHB http://www.ncbi.nlm.nih.gov/gene/?term=3945 "HEL-S-281, LDH-B, LDH-H, LDHBD, TRG-5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012307 3945 LDHB http://www.ncbi.nlm.nih.gov/gene/?term=3945 "HEL-S-281, LDH-B, LDH-HD, TRG-5, LDHB " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00012308 3945 LDHB http://www.ncbi.nlm.nih.gov/gene/?term=3945 "HEL-S-281, LDH-B, LDH-HD, TRG-5, LDHB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012309 3945 LDHB http://www.ncbi.nlm.nih.gov/gene/?term=3945 "HEL-S-281, LDH-B, LDH-HD, TRG-5, LDHB " mRNA Homo sapiens 12923260 Ribosome T-cell line Jurkat S1 nuclease protection assays "However, and as depicted in Figure 4 (Cytosol), mRNAs encoding GAPDH and LDH were present in both free and membrane-bound polysomes, and mRNAs encoding Hsp90 displayed a high enrichment in the membrane-bound fraction (75%-97%). Such partitioning of mRNAs to the ER was observed in 15 independent experiments using ER derived from Jurkat and J558 cells alike, thus confirming that mRNAs encoding signal-sequence-bearing proteins and mRNAs encoding cytosolic proteins are present on the ER. " RLID00012310 3945 LDHB http://www.ncbi.nlm.nih.gov/gene/?term=3945 "HEL-S-281, LDH-B, LDH-HD, TRG-5, LDHB " mRNA Homo sapiens 18192611 Ribosome HeLa cell Northern blot FIGURE 2. Subcellular mRNA distribution in SRP54 knock-down HeLa cell lines. (A) Total RNA from control HeLa (H) or SRP54 (54) stable knock-down cells was analyzed by Northern blot. (B) Cell surface expression of DR4 was determined by flow cytometry using no primary antibody (control) or DR4 antibody. (C) Cells were fractionated by sequential detergent extraction into cytosol (lane C) or membrane-bound (lane M) fractions. RNA isolated from total cells (lane T) or cell fractions was analyzed by Northern blot using the probes listed in Materials and Methods. Data are collected from Figure 2. RLID00012311 3945 LDHB http://www.ncbi.nlm.nih.gov/gene/?term=3945 "HEL-S-281, LDH-B, LDH-HD, TRG-5, LDHB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012312 394676 dazl http://www.ncbi.nlm.nih.gov/gene/?term=394676 "Xdazl, dazh1, dazla, spgyla, dazl " mRNA Xenopus tropicalis 14745962 Germ plasm Oocyte In situ hybridization "In this work, we showed that Xtdazl mRNA was localized in the germ plasm and was expressed from the previtellogenic oocyte to early tadpole, in testis and ovary. " RLID00012313 394676 dazl http://www.ncbi.nlm.nih.gov/gene/?term=394676 "Xdazl, dazh1, dazla, spgyla, dazl " mRNA Xenopus tropicalis 14745962 Germ plasm Oocyte In situ hybridization Xtdazl mRNA Is Expressed Specifically in the Germ Plasm and pPGCs Until the Early Tadpole Stage. RLID00012314 39475 MICAL-like http://www.ncbi.nlm.nih.gov/gene/?term=39475 "Dmel_CG11259, AAK93415, CG11259, Dmel\CG11259 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012315 3948 LDHC http://www.ncbi.nlm.nih.gov/gene/?term=3948 "CT32, LDH3, LDHX " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00012316 3948 LDHC http://www.ncbi.nlm.nih.gov/gene/?term=3948 "CT32, LDH3, LDHX " mRNA Homo sapiens 12923260 Ribosome T-cell line Jurkat S1 nuclease protection assays "However, and as depicted in Figure 4 (Cytosol), mRNAs encoding GAPDH and LDH were present in both free and membrane-bound polysomes, and mRNAs encoding Hsp90 displayed a high enrichment in the membrane-bound fraction (75%-97%). Such partitioning of mRNAs to the ER was observed in 15 independent experiments using ER derived from Jurkat and J558 cells alike, thus confirming that mRNAs encoding signal-sequence-bearing proteins and mRNAs encoding cytosolic proteins are present on the ER. " RLID00012317 3948 LDHC http://www.ncbi.nlm.nih.gov/gene/?term=3948 "CT32, LDH3, LDHX " mRNA Homo sapiens 18192611 Ribosome HeLa cell Northern blot FIGURE 2. Subcellular mRNA distribution in SRP54 knock-down HeLa cell lines. (A) Total RNA from control HeLa (H) or SRP54 (54) stable knock-down cells was analyzed by Northern blot. (B) Cell surface expression of DR4 was determined by flow cytometry using no primary antibody (control) or DR4 antibody. (C) Cells were fractionated by sequential detergent extraction into cytosol (lane C) or membrane-bound (lane M) fractions. RNA isolated from total cells (lane T) or cell fractions was analyzed by Northern blot using the probes listed in Materials and Methods. Data are collected from Figure 2. RLID00012318 3949 LDLR http://www.ncbi.nlm.nih.gov/gene/?term=3949 "FH, FHC, LDLCQ2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012319 3949 LDLR http://www.ncbi.nlm.nih.gov/gene/?term=3949 "FH, FHC, LDLCQ2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012320 3949 LDLR http://www.ncbi.nlm.nih.gov/gene/?term=3949 "FH, FHC, LDLCQ2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012321 3949 LDLR http://www.ncbi.nlm.nih.gov/gene/?term=3949 "FH, FHC, LDLCQ2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012322 394 ARHGAP5 http://www.ncbi.nlm.nih.gov/gene/?term=394 "GFI2, RhoGAP5, p190-B, p190BRhoGAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012323 394 ARHGAP5 http://www.ncbi.nlm.nih.gov/gene/?term=394 "GFI2, RhoGAP5, p190-B, p190BRhoGAP " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012324 394 ARHGAP5 http://www.ncbi.nlm.nih.gov/gene/?term=394 "GFI2, RhoGAP5, p190-B, p190BRhoGAP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012325 394 ARHGAP5 http://www.ncbi.nlm.nih.gov/gene/?term=394 "GFI2, RhoGAP5, p190-B, p190BRhoGAP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012326 394 ARHGAP5 http://www.ncbi.nlm.nih.gov/gene/?term=394 "GFI2, RhoGAP5, p190-B, p190BRhoGAP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012327 395069 COL2A1 http://www.ncbi.nlm.nih.gov/gene/?term=395069 mRNA Gallus gallus 1795029 Endoplasmic reticulum Corneal epithelia In situ hybridization "In this central region of the basal cells the probes specific for αlii) and α'l(II) hybridization showed the same pattern as the DiOCe(3) staining (Fig. 4D-F), indicating that an mRNA associated with the RER was labeled. " RLID00012328 395069 COL2A1 http://www.ncbi.nlm.nih.gov/gene/?term=395069 mRNA Gallus gallus 8838419 Endoplasmic reticulum Embryo In situ hybridization "The distribution of type II collagen mRNA was similar to the ER staining pattern, appearing to represent a subset of total ER. This study demonstrates that ER markers have a similar distribution as type II collagen mRNA in embryonic avian corneal epithelia. The type II mRNA distribution was similar to the RER pattern observed with TEM (Fig. 1) and anti-CPH immunohistochemistry (Figs. 2 and 4). " RLID00012329 39513 cmb http://www.ncbi.nlm.nih.gov/gene/?term=39513 "Dmel_CG10732, CG10732, Dmel\CG10732, NEST:bs28e06 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012330 39540 ssp2 http://www.ncbi.nlm.nih.gov/gene/?term=39540 "Dmel_CG9028, CG9028, Dmel\CG9028, Ssp2 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012331 395442 RHOA http://www.ncbi.nlm.nih.gov/gene/?term=395442 mRNA Gallus gallus 21146522 Perinuclear Fibroblast Fluorescence in situ hybridization "Figure 1A: Endogenous Arp2 mRNA (green) and Dia1 mRNA (red) are localized in the protrusions (indicated by arrows) and perinuclear region in the CEFs, respectively. Note that protrusions in this report are defined broadly to include lamellae and lamellipodia. " RLID00012332 395442 RHOA http://www.ncbi.nlm.nih.gov/gene/?term=395442 mRNA Gallus gallus 21146522 Lamellipodium Fibroblast Fluorescence in situ hybridization "Figure 1A: Endogenous Arp2 mRNA (green) and Dia1 mRNA (red) are localized in the protrusions (indicated by arrows) and perinuclear region in the CEFs, respectively. Note that protrusions in this report are defined broadly to include lamellae and lamellipodia. " RLID00012333 395442 RHOA http://www.ncbi.nlm.nih.gov/gene/?term=395442 mRNA Gallus gallus 21266463 Endoplasmic reticulum Fibroblast RT-PCR The combined results from our multiple approaches consistently demonstrate that Dia1 mRNA is localized on the ER membrane. Fig. 3. Dia1 mRNA is localized on the ER. RLID00012334 39547 26-29-p http://www.ncbi.nlm.nih.gov/gene/?term=39547 "Dmel_CG8947, 26/29kD-proteinase, CG8947, Dmel\CG8947, anon-SAGE:Wang-123, l(3)s3635 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012335 3954 LETM1 http://www.ncbi.nlm.nih.gov/gene/?term=3954 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012336 3954 LETM1 http://www.ncbi.nlm.nih.gov/gene/?term=3954 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012337 3954 LETM1 http://www.ncbi.nlm.nih.gov/gene/?term=3954 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012338 3954 LETM1 http://www.ncbi.nlm.nih.gov/gene/?term=3954 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012339 3955 LFNG http://www.ncbi.nlm.nih.gov/gene/?term=3955 SCDO3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012340 3956 LGALS1 http://www.ncbi.nlm.nih.gov/gene/?term=3956 "GAL1, GBP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012341 3956 LGALS1 http://www.ncbi.nlm.nih.gov/gene/?term=3956 "GAL1, GBP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012342 39572 nuf http://www.ncbi.nlm.nih.gov/gene/?term=39572 "Dmel_CG33991, CG32140, CG33991, CG7867, CIP-D2, Cy3-23, D2, Dmel\CG33991, EP3077, FIP3, NUF, Nuf, Nuf1, Nuf2p, anon-D2 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012343 39572 nuf http://www.ncbi.nlm.nih.gov/gene/?term=39572 "Dmel_CG33991, CG32140, CG33991, CG7867, CIP-D2, Cy3-23, D2, Dmel\CG33991, EP3077, FIP3, NUF, Nuf, Nuf1, Nuf2p, anon-D2 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012344 39583 bbg http://www.ncbi.nlm.nih.gov/gene/?term=39583 "Dmel_CG42230, BBG, C96, CG42230, CG9587, CG9598, Dmel\CG42230, Dmel_CG9587, Dmel_CG9598 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012345 39583 bbg http://www.ncbi.nlm.nih.gov/gene/?term=39583 "Dmel_CG42230, BBG, C96, CG42230, CG9587, CG9598, Dmel\CG42230, Dmel_CG9587, Dmel_CG9598 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012346 39583 bbg http://www.ncbi.nlm.nih.gov/gene/?term=39583 "Dmel_CG42230, BBG, C96, CG42230, CG9587, CG9598, Dmel\CG42230, Dmel_CG9587, Dmel_CG9598 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012347 39583 bbg http://www.ncbi.nlm.nih.gov/gene/?term=39583 "Dmel_CG42230, BBG, C96, CG42230, CG9587, CG9598, Dmel\CG42230, Dmel_CG9587, Dmel_CG9598 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012348 3958 LGALS3 http://www.ncbi.nlm.nih.gov/gene/?term=3958 "CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012349 3958 LGALS3 http://www.ncbi.nlm.nih.gov/gene/?term=3958 "CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012350 39592 shd http://www.ncbi.nlm.nih.gov/gene/?term=39592 "Dmel_CG13478, 314a1, CG13478, CYP314A1, Cyp314a1, Dmel\CG13478, cyp314a1 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012351 3959 LGALS3BP http://www.ncbi.nlm.nih.gov/gene/?term=3959 "90K, BTBD17B, CyCAP, M2BP, MAC-2-BP, TANGO10B, gp90 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012352 3959 LGALS3BP http://www.ncbi.nlm.nih.gov/gene/?term=3959 "90K, BTBD17B, CyCAP, M2BP, MAC-2-BP, TANGO10B, gp90 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012353 3959 LGALS3BP http://www.ncbi.nlm.nih.gov/gene/?term=3959 "90K, BTBD17B, CyCAP, M2BP, MAC-2-BP, TANGO10B, gp90 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012354 395 ARHGAP6 http://www.ncbi.nlm.nih.gov/gene/?term=395 "RHOGAP6, RHOGAPX-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012355 3960 LGALS4 http://www.ncbi.nlm.nih.gov/gene/?term=3960 "GAL4, L36LBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012356 3960 LGALS4 http://www.ncbi.nlm.nih.gov/gene/?term=3960 "GAL4, L36LBP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012357 396101 AVP http://www.ncbi.nlm.nih.gov/gene/?term=396101 mRNA Gallus gallus 10817905 Axon Hypothalamus In Situ Hybridization|RT-PCR "AVT mRNA was detected in the median eminence and neurohypophysis representing the distal parts of the HNS, mainly consisting of axons and/or axon terminals. " RLID00012358 396133 FN1 http://www.ncbi.nlm.nih.gov/gene/?term=396133 FN mRNA Gallus gallus 2103522 Cytoplasm Embryo In situ hybridization "Fibronectin mRNA were essentially located in cytoplasm, associated with the rough endoplasmic reticulum (fig 5a, b, c), but a few grains were observed in the nucleus around the nucleolus (fig 5d). In some instances, the location of the label is obviously over the rough membranes of the endoplasmic reticulum (fig 5c). " RLID00012359 396133 FN1 http://www.ncbi.nlm.nih.gov/gene/?term=396133 FN mRNA Gallus gallus 2103522 Endoplasmic reticulum Embryo In situ hybridization "Fibronectin mRNA were essentially located in cytoplasm, associated with the rough endoplasmic reticulum (fig 5a, b, c), but a few grains were observed in the nucleus around the nucleolus (fig 5d). In some instances, the location of the label is obviously over the rough membranes of the endoplasmic reticulum (fig 5c). " RLID00012360 396147 ACTR2 http://www.ncbi.nlm.nih.gov/gene/?term=396147 mRNA Gallus gallus 21146522 Lamellipodium Fibroblast Fluorescence in situ hybridization "Figure 1A: Endogenous Arp2 mRNA (green) and Dia1 mRNA (red) are localized in the protrusions (indicated by arrows) and perinuclear region in the CEFs, respectively. Note that protrusions in this report are defined broadly to include lamellae and lamellipodia. " RLID00012361 396147 ACTR2 http://www.ncbi.nlm.nih.gov/gene/?term=396147 mRNA Gallus gallus 21146522 Perinuclear Fibroblast Fluorescence in situ hybridization "Figure 1A: Endogenous Arp2 mRNA (green) and Dia1 mRNA (red) are localized in the protrusions (indicated by arrows) and perinuclear region in the CEFs, respectively. Note that protrusions in this report are defined broadly to include lamellae and lamellipodia. " RLID00012362 396147 ACTR2 http://www.ncbi.nlm.nih.gov/gene/?term=396147 mRNA Gallus gallus 15923655 Cell leading edge Fibroblast Fluorescence in situ hybridization "Figure 7: Quantification of Arp2/3-complex mRNA localization in fibroblasts. The proportion of the cells with localized mRNA was quantified by counting all the cells in randomly selected fields in the fluorescence microscope. 300-500 cells were scored for each mRNA from three independent experiments. Error bars indicate s.e.m. **, statistically significant (P<0.01) differences from control basal level of poly-A RNA. " RLID00012363 39625 mnd http://www.ncbi.nlm.nih.gov/gene/?term=39625 "Dmel_CG3297, CG3297, Dmel\CG3297, SG29, l(3)B5, l(3)SG29, l(3)ds-5, l(3)ds5, l(3)o52, md " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012364 3963 LGALS7 http://www.ncbi.nlm.nih.gov/gene/?term=3963 "GAL7, LGALS7A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012365 3964 LGALS8 http://www.ncbi.nlm.nih.gov/gene/?term=3964 "Gal-8, PCTA-1, PCTA1, Po66-CBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012366 3964 LGALS8 http://www.ncbi.nlm.nih.gov/gene/?term=3964 "Gal-8, PCTA-1, PCTA1, Po66-CBP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012367 3964 LGALS8 http://www.ncbi.nlm.nih.gov/gene/?term=3964 "Gal-8, PCTA-1, PCTA1, Po66-CBP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012368 396526 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=396526 "Bact, actin " mRNA Gallus gallus 2277064 Cytoplasm Skeletal Myoblast|Fibroblast In situ hybridization "In the 14% of cells with localized actin mRNA, the degree of regionalization was not as great as in cells cultured for 2 d, i.e., substantial mounts of actin mRNA were found throughout the cytoplasm (Fig. 1, c and d). " RLID00012369 396526 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=396526 "Bact, actin " mRNA Gallus gallus 2738094 Lamellipodium Skeletal Myoblast|Fibroblast Immunocytochemistry|In situ hybridization "Actin mRNA was found to be more predominant in lamellipodia of motile cells, confirming previous results. " RLID00012370 396526 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=396526 "Bact, actin " mRNA Gallus gallus 3698103 Lamellipodium Embryo blasts|Fibroblast In situ hybridization "Actin mRNA concentrations were highest at cell extremities, generally in lamellipodia, where grain densities were up to 16-fold higher than in areas near the nucleus. Vimentin mRNA, unlike actin mRNA, was distributed near the nucleus. Tubulin mRNA appeared most concentrated in the peripheral cytoplasm. These results demonstrate that cytoplasmic mRNAs are localized in specific, nonrandom cellular patterns and that localized concentrations of specific proteins may result from corresponding localization of their respective mRNAs. Hence, actin mRNA distribution may result in increased concentration of actin filaments in lamellipodia of motile cells. " RLID00012371 396526 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=396526 "Bact, actin " mRNA Gallus gallus 15377515 Lamellipodium Fibroblast In situ hybridization "Beta-actin mRNA signals were most abundant in active lamellipodia, which are protrusions that cells extend to adhere to surfaces. The preponderance of warmer colors in the most prominent lamellipodia indicates that β-actin mRNA was very abundant in those regions. " RLID00012372 396526 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=396526 "Bact, actin " mRNA Gallus gallus 15923655 Cell leading edge Fibroblast Fluorescence in situ hybridization "The localization of the Arp2/3 complex mRNAs is dependent on both actin filaments and microtubules, because disruption of either cytoskeletal system (with cytochalasin D and colchicine, respectively) inhibited the localization of all seven subunit mRNAs. To address these questions, double detection of two types of mRNAs simultaneously in the same cells was performed by sequential FISH-TSA. As shown in Fig. 5A-C, Arp3 mRNA appears not to be precisely colocalized with β-actin mRNA, although they both concentrate together in the protrusions. In addition, the Arp2 and Arp3 mRNAs also do not colocalize, although they are both concentrated together in the protrusions (Fig. 5D-F). " RLID00012373 396526 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=396526 "Bact, actin " mRNA Gallus gallus 2095368 Lamellipodium Fibroblastic single cell In situ hybridization "When beta-actin probes were used, two of 11 probes were highly sensitive, and, in pooling them together, the localization of beta-actin mRNA in fibroblastic single cells was evident at the leading edge of the motile cells, the lamellipodium. beta-Actin mRNA was not detected in myotubes except at the ends where contact was made with substrate. This indicates that both beta and cardiac actin mRNA can coexist in the same myotube cytoplasm but at different locations. " RLID00012374 396526 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=396526 "Bact, actin " mRNA Gallus gallus 15923655 Cell leading edge Fibroblast Fluorescence in situ hybridization "Figure 7: Quantification of Arp2/3-complex mRNA localization in fibroblasts. The proportion of the cells with localized mRNA was quantified by counting all the cells in randomly selected fields in the fluorescence microscope. 300-500 cells were scored for each mRNA from three independent experiments. Error bars indicate s.e.m. **, statistically significant (P<0.01) differences from control basal level of poly-A RNA. " RLID00012375 3965 LGALS9 http://www.ncbi.nlm.nih.gov/gene/?term=3965 "HUAT, LGALS9A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012376 396 ARHGDIA http://www.ncbi.nlm.nih.gov/gene/?term=396 "GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012377 396 ARHGDIA http://www.ncbi.nlm.nih.gov/gene/?term=396 "GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012378 396 ARHGDIA http://www.ncbi.nlm.nih.gov/gene/?term=396 "GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012379 39720 fwe http://www.ncbi.nlm.nih.gov/gene/?term=39720 "Dmel_CG6151, CG6151, Dmel\CG6151, anon-WO0118547.242, dFwe " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012380 39720 fwe http://www.ncbi.nlm.nih.gov/gene/?term=39720 "Dmel_CG6151, CG6151, Dmel\CG6151, anon-WO0118547.242, dFwe " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012381 39758 CG5235 http://www.ncbi.nlm.nih.gov/gene/?term=39758 Dmel_ Dmel\CG5235 mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012382 39764 Zn72D http://www.ncbi.nlm.nih.gov/gene/?term=39764 "Dmel_CG5215, CG5215, Dmel\CG5215, ZN72D, l(3)72Dk, zn72D " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012383 3977 LIFR http://www.ncbi.nlm.nih.gov/gene/?term=3977 "CD118, LIF-R, SJS2, STWS, SWS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012384 3977 LIFR http://www.ncbi.nlm.nih.gov/gene/?term=3977 "CD118, LIF-R, SJS2, STWS, SWS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012385 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 7539356 Mitochondrion Oocyte In situ hybridization "One of these, through which Xlsirts, Xcat2 and Xwnt11 are localized, involves transport during stages 1 and 2 of oogenesis via a region of the mitochondrial cloud that we call the message transport organizer or METRO. This pathway involved three steps, transport of RNA from the GV to the mitochondrial cloud, sorting of the RNAs to specific regions of the METRO, and translocation to and anchoring at the vegetal cortex. " RLID00012386 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 7867501 Vegetal Oocyte - "Xcat-2 is exclusively localized to the mitochondrial cloud in stage I oocytes, moves with this body into the vegetal cortex during stage II and, later, partitions into islands consistent with it being a component of the germ plasm. " RLID00012387 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 7867501 Mitochondrion Oocyte - "Xcat-2 is exclusively localized to the mitochondrial cloud in stage I oocytes, moves with this body into the vegetal cortex during stage II and, later, partitions into islands consistent with it being a component of the germ plasm. " RLID00012388 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 7867501 Germ plasm Embryo - "Xcat-2 is exclusively localized to the mitochondrial cloud in stage I oocytes, moves with this body into the vegetal cortex during stage II and, later, partitions into islands consistent with it being a component of the germ plasm. " RLID00012389 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 8223259 Cytoskeleton Oocyte In situ hybridization "Furthermore, Vg1 and Xcat-2 RNA appear to co-distribute to the cortex, a region particularly concentrated in cytoskeletal elements which include intermediate laments. " RLID00012390 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 8873762 Vegetal Oocyte In situ hybridization "To further analyze the mechanisms involved in RNA transport, in situ hybridization and autoradiography were used to follow the localization of endogenous Vg1 and injected Xcat-2 transcripts in stage IV oocytes. We show that Xcat-2 is competent to localize to the vegetal cortex quite independently of the mitochondrial cloud. " RLID00012391 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 8873762 Germ plasm Oocyte In situ hybridization "Xcat-2 RNA, a component of the germ plasm in Xenopus, localizes with the mitochondrial cloud material to the vegetal cortex in stage II oocytes. Vg1 RNA also localizes to the vegetal cortex, but later in stage III/IV oocytes, using a microtubule dependent pathway. To further analyze the mechanisms involved in RNA transport, in situ hybridization and autoradiography were used to follow the localization of endogenous Vg1 and injected Xcat-2 transcripts in stage IV oocytes. We show that Xcat-2 is competent to localize to the vegetal cortex quite independently of the mitochondrial cloud. " RLID00012392 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 8948579 Cytoplasm Oocyte In situ hybridization During translocation through the cytoplasm Xlsirt and Xcat2 RNAs were detected associated with cytoplasmic particles of different morphologies. RLID00012393 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 8948579 Mitochondrion Oocyte In situ hybridization "In the present study we analyzed the properties of the METRO pathway, which localizes Xlsirt, Xcat2, and Xwnt11 RNAs to a specific region of the vegetal cortex during stage 1 of oogenesis. A combination of methodologies involving both fixed material and living oocytes was used to analyze RNA localization. We show that in early diplotene pre-stage 1 oocytes (25-50 microm in diameter) both endogenous and injected exogenous METRO RNAs translocated to multiple mitochondrial aggregates (pre-mitochondrial clouds) that surround the germinal vesicle (GV). However, by early stage 1 (diplotene oocytes, 50-200 microm), all three of the RNAs discriminated between the different clouds and translocated exclusively within the METRO of a single mitochondrial cloud. " RLID00012394 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 8948579 Vegetal Oocyte In situ hybridization "In the present study we analyzed the properties of the METRO pathway, which localizes Xlsirt, Xcat2, and Xwnt11 RNAs to a specific region of the vegetal cortex during stage 1 of oogenesis. A combination of methodologies involving both fixed material and living oocytes was used to analyze RNA localization. We show that in early diplotene pre-stage 1 oocytes (25-50 microm in diameter) both endogenous and injected exogenous METRO RNAs translocated to multiple mitochondrial aggregates (pre-mitochondrial clouds) that surround the germinal vesicle (GV). However, by early stage 1 (diplotene oocytes, 50-200 microm), all three of the RNAs discriminated between the different clouds and translocated exclusively within the METRO of a single mitochondrial cloud. " RLID00012395 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 9739112 Vegetal Oocyte In situ hybridization "We focused on Xlsirts, Xcat2, and Xwnt11 transcripts that are localized to the vegetal cortex through a region of the mitochondrial cloud called the messenger transport organizer (METRO) that also contains the nuage or germ plasm. At the ultrastructural level Xcat2 mRNA was detected on germinal granules while Xlsirts and Xwnt11 were associated with a fibrillar network of the germ plasm in stage-1 and stage-4 oocytes. " RLID00012396 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 9739112 Mitochondrion Oocyte In situ hybridization "We focused on Xlsirts, Xcat2, and Xwnt11 transcripts that are localized to the vegetal cortex through a region of the mitochondrial cloud called the messenger transport organizer (METRO) that also contains the nuage or germ plasm. At the ultrastructural level Xcat2 mRNA was detected on germinal granules while Xlsirts and Xwnt11 were associated with a fibrillar network of the germ plasm in stage-1 and stage-4 oocytes. " RLID00012397 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 10625548 Mitochondrion Oocyte In situ hybridization|Electron microscopy "Immediately after the 16-cell nest stage, Xcat2 mRNA was detected in early meiotic oocytes localized to the mitochondrial aggregate, the precursor to the mitochondrial cloud (Fig. 1A). Xcat2 mRNA was located between the mitochondria at the periphery of the area containing the mitochondrial cement (Fig. 1A). " RLID00012398 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 11309203 Vegetal Oocyte In situ hybridization "The IVC retained mRNAs with a granular texture, and their distribution patterns resembled those of the whole oocyte. Vg1 was distributed in the entire cortex, whereas Xwnt-11 and Xcat-2 were both concentrated as a disc at the vegetal pole. " RLID00012399 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 11784096 Germ plasm Oocyte In situ hybridization "The germ plasm is a specialized region of oocyte cytoplasm that contains determinants of germ cell fate. In Xenopus oocytes, the germ plasm is a part of the METRO region of mitochondrial cloud. It contains the germinal granules and a variety of coding and noncoding RNAs that include Xcat2, Xlsirts, Xdazl, DEADSouth, Xpat, Xwnt11, fatVg, B7/Fingers, C10/XFACS, and mitochondrial large and small rRNA. We analyzed the distribution of these 11 different RNAs within the various compartments of germ plasm during Xenopus oogenesis and development by using whole-mount electron microscopy in situ hybridization. " RLID00012400 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 12401170 Vegetal Oocyte In situ hybridization "Figure 2. In Situ Hybridization of Newly Discovered Localized mRNAs In situ hybridization to Xcat-2 mRNA and Xpat mRNAs demonstrates examples of RNAs that localize via the early pathway. Note that most of the RNA is associated with the mitochondrial cloud in stage I oocytes, with little background in the rest of the cytoplasm. By stage II, these RNAs have migrated with the cloud to the vegetal cortex, and there is no detectable RNA in the remaining cytoplasm. " RLID00012401 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 15292452 Mitochondrion Oocyte Immunofluorescence "To understand the mechanism of the early pathway through which RNAs localize to the MC, we applied live confocal imaging and photobleaching analysis to oocytes microinjected with fluorescent Xcat2 and Xdazl RNA constructs. These RNAs dispersed evenly throughout the cytoplasm through diffusion and then became progressively immobilized and formed aggregates in the MC (mitochondrial cloud). " RLID00012402 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 19223445 Mitochondrion Oocyte Quantitative RNA localization assay "Early RNAs, such as Xcat-2, Xlsirt, and Xwnt, become localized to a large subcellular structure called the Balbiani body or mitochondrial cloud. " RLID00012403 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 23626739 Germ plasm Oocyte Microscopy "We find that in mid oogenesis nanos1 RNA also localises to germ plasm but also by the late pathway. Late pathway RNAs, Vg1 and VegT, also may localise into germ plasm. " RLID00012404 397875 nanos1 http://www.ncbi.nlm.nih.gov/gene/?term=397875 "nos1, xcat-2, xcat2, xnos1 " mRNA Xenopus laevis 8787767 Mitochondrion Oocyte In situ hybridization Xcat-2 RNA specifically localizes to the mitochondrial cloud and moves with it to the vegetal subcortex in stage II oocytes. RLID00012405 3978 LIG1 http://www.ncbi.nlm.nih.gov/gene/?term=3978 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012406 397986 vegt-a http://www.ncbi.nlm.nih.gov/gene/?term=397986 "Apod, antipodean, brat, tVegT, xombi " mRNA Xenopus laevis 15496522 Vegetal Oocyte Immunofluorescence "We show that double-stranded RNA-binding Staufen proteins are present in the oocytes of a vertebrate, Xenopus, and are localized to the vegetal cytoplasm, a region where important mRNAs including VegT and Vg1 mRNA become localized. " RLID00012407 397986 vegt-a http://www.ncbi.nlm.nih.gov/gene/?term=397986 "Apod, antipodean, brat, tVegT, xombi " mRNA Xenopus laevis 15515051 Vegetal Oocyte In situ hybridization "VegT and other RNAs, involved in embryonic patterning, follow the late pathway. We have shown that the R. pipiens RNA orthologues of Xdazl and VegT are both localized to the vegetal cortex, suggesting that the two RNA localization pathways exist in R. pipiens. " RLID00012408 397990 vegt-b http://www.ncbi.nlm.nih.gov/gene/?term=397990 "Apod, antipodean, brat, tVegT, vegt, xombi " mRNA Xenopus laevis 15496522 Vegetal Oocyte Immunofluorescence "We show that double-stranded RNA-binding Staufen proteins are present in the oocytes of a vertebrate, Xenopus, and are localized to the vegetal cytoplasm, a region where important mRNAs including VegT and Vg1 mRNA become localized. " RLID00012409 397990 vegt-b http://www.ncbi.nlm.nih.gov/gene/?term=397990 "Apod, antipodean, brat, tVegT, vegt, xombi " mRNA Xenopus laevis 15515051 Vegetal Oocyte In situ hybridization "VegT and other RNAs, involved in embryonic patterning, follow the late pathway. We have shown that the R. pipiens RNA orthologues of Xdazl and VegT are both localized to the vegetal cortex, suggesting that the two RNA localization pathways exist in R. pipiens. " RLID00012410 397990 vegt-b http://www.ncbi.nlm.nih.gov/gene/?term=397990 "Apod, antipodean, brat, tVegT, vegt, xombi " mRNA Xenopus laevis 23626739 Germ plasm Oocyte Microscopy "We find that in mid oogenesis nanos1 RNA also localises to germ plasm but also by the late pathway. Late pathway RNAs,Vg1 and VegT, also may localise into germ plasm. " RLID00012411 397 ARHGDIB http://www.ncbi.nlm.nih.gov/gene/?term=397 "D4, GDIA2, GDID4, LYGDI, Ly-GDI, RAP1GN1, RhoGDI2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012412 398019 ddx4 http://www.ncbi.nlm.nih.gov/gene/?term=398019 "vasa, vlg1 " mRNA Xenopus laevis 10830432 Cytoplasm Oocyte In situ hybridization "By hybridization, XVLG1 ribonucleic acid (RNA) was shown to be present throughout the cytoplasm in oocytes at stages I-III, except for the mitochondrial cloud. " RLID00012413 398041 dazl http://www.ncbi.nlm.nih.gov/gene/?term=398041 "Xdazl, dazh-B, dazl-a, dazl1, dazla, spgyla, dazl " mRNA Xenopus laevis 9486791 Germ plasm Oocyte In situ hybridization "We have identified a localized RNA component of Xenopus germ plasm. This RNA, Xdazl (Xenopus DAZ-like), encodes a protein homologous to human DAZ (Deleted in Azoospermia), vertebrate DAZL and Drosophila Boule proteins. Human males deficient in DAZ have few or no sperm and boule mutant flies exhibit complete azoospermia and male sterility. Xdazl RNA was detected in the mitochondrial cloud and vegetal cortex of oocytes. In early embryos, the RNA was localized exclusively in the germ plasm. " RLID00012414 398041 dazl http://www.ncbi.nlm.nih.gov/gene/?term=398041 "Xdazl, dazh-B, dazl-a, dazl1, dazla, spgyla, dazl " mRNA Xenopus laevis 9486791 Mitochondrion Oocyte In situ hybridization "We have identified a localized RNA component of Xenopus germ plasm. This RNA, Xdazl (Xenopus DAZ-like), encodes a protein homologous to human DAZ (Deleted in Azoospermia), vertebrate DAZL and Drosophila Boule proteins. Human males deficient in DAZ have few or no sperm and boule mutant flies exhibit complete azoospermia and male sterility. Xdazl RNA was detected in the mitochondrial cloud and vegetal cortex of oocytes. In early embryos, the RNA was localized exclusively in the germ plasm. " RLID00012415 398041 dazl http://www.ncbi.nlm.nih.gov/gene/?term=398041 "Xdazl, dazh-B, dazl-a, dazl1, dazla, spgyla, dazl " mRNA Xenopus laevis 9486791 Vegetal Oocyte In situ hybridization "We have identified a localized RNA component of Xenopus germ plasm. This RNA, Xdazl (Xenopus DAZ-like), encodes a protein homologous to human DAZ (Deleted in Azoospermia), vertebrate DAZL and Drosophila Boule proteins. Human males deficient in DAZ have few or no sperm and boule mutant flies exhibit complete azoospermia and male sterility. Xdazl RNA was detected in the mitochondrial cloud and vegetal cortex of oocytes. In early embryos, the RNA was localized exclusively in the germ plasm. " RLID00012416 398041 dazl http://www.ncbi.nlm.nih.gov/gene/?term=398041 "Xdazl, dazh-B, dazl-a, dazl1, dazla, spgyla, dazl " mRNA Xenopus laevis 10631166 Germ plasm Embryo In situ hybridization Xdazl is an RNA component of Xenopus germ plasm and encodes an RNA-binding protein that can act as a functional homologue of Drosophila boule. RLID00012417 398041 dazl http://www.ncbi.nlm.nih.gov/gene/?term=398041 "Xdazl, dazh-B, dazl-a, dazl1, dazla, spgyla, dazl " mRNA Xenopus laevis 11397009 Germ plasm Oocyte In situ hybridization "Axdazl is homologous to Xdazl, a component of Xenopus germ plasm found in the vegetal pole of oocytes and eggs. Axdazl RNA is not localized in axolotl oocytes, and, furthermore, these oocytes do not contain the mitochondrial cloud that localizes Xdazl and other germ plasm components in Xenopus. " RLID00012418 398041 dazl http://www.ncbi.nlm.nih.gov/gene/?term=398041 "Xdazl, dazh-B, dazl-a, dazl1, dazla, spgyla, dazl " mRNA Xenopus laevis 11784096 Germ plasm Oocyte In situ hybridization "The germ plasm is a specialized region of oocyte cytoplasm that contains determinants of germ cell fate. In Xenopus oocytes, the germ plasm is a part of the METRO region of mitochondrial cloud. It contains the germinal granules and a variety of coding and noncoding RNAs that include Xcat2, Xlsirts, Xdazl, DEADSouth, Xpat, Xwnt11, fatVg, B7/Fingers, C10/XFACS, and mitochondrial large and small rRNA. We analyzed the distribution of these 11 different RNAs within the various compartments of germ plasm during Xenopus oogenesis and development by using whole-mount electron microscopy in situ hybridization. " RLID00012419 398041 dazl http://www.ncbi.nlm.nih.gov/gene/?term=398041 "Xdazl, dazh-B, dazl-a, dazl1, dazla, spgyla, dazl " mRNA Xenopus laevis 15292452 Mitochondrion Oocyte Immunofluorescence "To understand the mechanism of the early pathway through which RNAs localize to the MC, we applied live confocal imaging and photobleaching analysis to oocytes microinjected with fluorescent Xcat2 and Xdazl RNA constructs. These RNAs dispersed evenly throughout the cytoplasm through diffusion and then became progressively immobilized and formed aggregates in the MC (mitochondrial cloud). " RLID00012420 398041 dazl http://www.ncbi.nlm.nih.gov/gene/?term=398041 "Xdazl, dazh-B, dazl-a, dazl1, dazla, spgyla, dazl " mRNA Xenopus laevis 15515051 Vegetal Oocyte In situ hybridization "VegT and other RNAs, involved in embryonic patterning, follow the late pathway. We have shown that the R. pipiens RNA orthologues of Xdazl and VegT are both localized to the vegetal cortex, suggesting that the two RNA localization pathways exist in R. pipiens. " RLID00012421 3980 LIG3 http://www.ncbi.nlm.nih.gov/gene/?term=3980 LIG2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012422 3980 LIG3 http://www.ncbi.nlm.nih.gov/gene/?term=3980 LIG2 mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00012423 3980 LIG3 http://www.ncbi.nlm.nih.gov/gene/?term=3980 LIG2 mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00012424 398143 plin2 http://www.ncbi.nlm.nih.gov/gene/?term=398143 "adfp, adipophilin, adrp, fatvg " mRNA Xenopus laevis 10529413 Vegetal Oocyte In situ hybridization "The fatvg transcript, unlike Vg1 which localizes strictly through the Late pathway, also associates with the mitochondrial cloud that is characteristic of the METRO or Early pathway. This suggests that fatvg mRNA may utilize both the METRO and Late pathways to localize to the vegetal cortex during oogenesis. " RLID00012425 398143 plin2 http://www.ncbi.nlm.nih.gov/gene/?term=398143 "adfp, adipophilin, adrp, fatvg " mRNA Xenopus laevis 10529413 Mitochondrion Oocyte In situ hybridization "The fatvg transcript, unlike Vg1 which localizes strictly through the Late pathway, also associates with the mitochondrial cloud that is characteristic of the METRO or Early pathway. This suggests that fatvg mRNA may utilize both the METRO and Late pathways to localize to the vegetal cortex during oogenesis. " RLID00012426 398143 plin2 http://www.ncbi.nlm.nih.gov/gene/?term=398143 "adfp, adipophilin, adrp, fatvg " mRNA Xenopus laevis 11118900 Vegetal Oocyte In situ hybridization "Fatvg mRNA is localized through the late pathway to the vegetal cortex. Like Vg1 mRNA fatvg is distributed throughout the entire cortex; however, unlike Vg1 there is a small fraction of the fatvg mRNA that is associated with the mitochondrial cloud. In early cleavage stage embryos, fatvg mRNA is associated with the germ plasm located at the tips of the vegetal blastomeres of the embryo. " RLID00012427 398143 plin2 http://www.ncbi.nlm.nih.gov/gene/?term=398143 "adfp, adipophilin, adrp, fatvg " mRNA Xenopus laevis 11118900 Mitochondrion Oocyte In situ hybridization "Fatvg mRNA is localized through the late pathway to the vegetal cortex. Like Vg1 mRNA fatvg is distributed throughout the entire cortex; however, unlike Vg1 there is a small fraction of the fatvg mRNA that is associated with the mitochondrial cloud. In early cleavage stage embryos, fatvg mRNA is associated with the germ plasm located at the tips of the vegetal blastomeres of the embryo. " RLID00012428 398143 plin2 http://www.ncbi.nlm.nih.gov/gene/?term=398143 "adfp, adipophilin, adrp, fatvg " mRNA Xenopus laevis 11118900 Germ plasm Embryo In situ hybridization "Fatvg mRNA is localized through the late pathway to the vegetal cortex. Like Vg1 mRNA fatvg is distributed throughout the entire cortex; however, unlike Vg1 there is a small fraction of the fatvg mRNA that is associated with the mitochondrial cloud. In early cleavage stage embryos, fatvg mRNA is associated with the germ plasm located at the tips of the vegetal blastomeres of the embryo. " RLID00012429 398143 plin2 http://www.ncbi.nlm.nih.gov/gene/?term=398143 "adfp, adipophilin, adrp, fatvg " mRNA Xenopus laevis 11784096 Germ plasm Oocyte In situ hybridization "The germ plasm is a specialized region of oocyte cytoplasm that contains determinants of germ cell fate. In Xenopus oocytes, the germ plasm is a part of the METRO region of mitochondrial cloud. It contains the germinal granules and a variety of coding and noncoding RNAs that include Xcat2, Xlsirts, Xdazl, DEADSouth, Xpat, Xwnt11, fatVg, B7/Fingers, C10/XFACS, and mitochondrial large and small rRNA. We analyzed the distribution of these 11 different RNAs within the various compartments of germ plasm during Xenopus oogenesis and development by using whole-mount electron microscopy in situ hybridization. " RLID00012430 398143 plin2 http://www.ncbi.nlm.nih.gov/gene/?term=398143 "adfp, adipophilin, adrp, fatvg " mRNA Xenopus laevis 17939116 Germ plasm Oocyte In situ hybridization "We found that centroid mRNA is localized in Xenopus oocytes by a combination of early and late pathways, a pattern of localization that is very similar to the intermediate pathway localization of fatvg mRNA, another germ-plasm-localized RNA in Xenopus oocytes. Also, centroid mRNA is present in the mitochondrial cloud and in the germ plasm at the surface of germinal granules. " RLID00012431 398145 tacc3 http://www.ncbi.nlm.nih.gov/gene/?term=398145 "eric1, maskin, masking, xmaskin " mRNA Xenopus laevis 11081630 Mitotic spindle Embryo Whole mount In Situ Hybridization "CPEB, Maskin, and Cyclin B1 mRNA at the mitotic apparatus: implications for local translational control of cell division. " RLID00012432 39816 Cpr72Ec http://www.ncbi.nlm.nih.gov/gene/?term=39816 "Dmel_CG4784, CG4784, CT15377, Dmel\CG4784 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012433 398180 ddx25 http://www.ncbi.nlm.nih.gov/gene/?term=398180 "deadsouth, grth " mRNA Xenopus laevis 10906480 Vegetal Oocyte In situ hybridization DEADSouth was selected in a screen for localized RNAs in Xenopus oocytes. In situ hybridization analysis shows that DEADSouth localizes to the vegetal cortex via the mitochondrial cloud early in oogenesis and segregates with germ plasm during early embryogenesis. RLID00012434 398180 ddx25 http://www.ncbi.nlm.nih.gov/gene/?term=398180 "deadsouth, grth " mRNA Xenopus laevis 10906480 Mitochondrion Oocyte In situ hybridization DEADSouth was selected in a screen for localized RNAs in Xenopus oocytes. In situ hybridization analysis shows that DEADSouth localizes to the vegetal cortex via the mitochondrial cloud early in oogenesis and segregates with germ plasm during early embryogenesis. RLID00012435 398180 ddx25 http://www.ncbi.nlm.nih.gov/gene/?term=398180 "deadsouth, grth " mRNA Xenopus laevis 10906480 Germ plasm Oocyte In situ hybridization DEADSouth was selected in a screen for localized RNAs in Xenopus oocytes. In situ hybridization analysis shows that DEADSouth localizes to the vegetal cortex via the mitochondrial cloud early in oogenesis and segregates with germ plasm during early embryogenesis. RLID00012436 398180 ddx25 http://www.ncbi.nlm.nih.gov/gene/?term=398180 "deadsouth, grth " mRNA Xenopus laevis 11784096 Germ plasm Oocyte In situ hybridization "The germ plasm is a specialized region of oocyte cytoplasm that contains determinants of germ cell fate. In Xenopus oocytes, the germ plasm is a part of the METRO region of mitochondrial cloud. It contains the germinal granules and a variety of coding and noncoding RNAs that include Xcat2, Xlsirts, Xdazl, DEADSouth, Xpat, Xwnt11, fatVg, B7/Fingers, C10/XFACS, and mitochondrial large and small rRNA. We analyzed the distribution of these 11 different RNAs within the various compartments of germ plasm during Xenopus oogenesis and development by using whole-mount electron microscopy in situ hybridization. " RLID00012437 398180 ddx25 http://www.ncbi.nlm.nih.gov/gene/?term=398180 "deadsouth, grth " mRNA Xenopus laevis 23429978 Germ plasm Embryo Fluorescence in situ hybridization DEADSouth mRNA is a component of germ plasm in Xenopus laevis and encodes a DDX25 DEAD-box RNA helicase. RLID00012438 398191 chek1 http://www.ncbi.nlm.nih.gov/gene/?term=398191 chk1 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00012439 3981 LIG4 http://www.ncbi.nlm.nih.gov/gene/?term=3981 LIG4S mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012440 3981 LIG4 http://www.ncbi.nlm.nih.gov/gene/?term=3981 LIG4S mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012441 3982 LIM2 http://www.ncbi.nlm.nih.gov/gene/?term=3982 "CTRCT19, MP17, MP19 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012442 39833 aos http://www.ncbi.nlm.nih.gov/gene/?term=39833 "Dmel_CG4531, Aos, Argos, CG4531, DmAos, Dmel\CG4531, arg, gil, l(3)05845, l(3)05959, l(3)j5E11, l(3)rJ472, l(3)rJ812, l(3)rQ526, rlt, sty " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012443 3983 ABLIM1 http://www.ncbi.nlm.nih.gov/gene/?term=3983 "ABLIM, LIMAB1, LIMATIN, abLIM-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012444 3983 ABLIM1 http://www.ncbi.nlm.nih.gov/gene/?term=3983 "ABLIM, LIMAB1, LIMATIN, abLIM-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012445 3984 LIMK1 http://www.ncbi.nlm.nih.gov/gene/?term=3984 "LIMK, LIMK-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012446 398520 LOC398520 http://www.ncbi.nlm.nih.gov/gene/?term=398520 mRNA Xenopus laevis 12915321 Mitochondrion Oocyte In situ hybridization In situ hybridization analysis shows that Germes transcript localizes to the vegetal cortex via the mitochondrial cloud early in oogenesis and segregates with the germ plasm during early embryogenesis. Our data indicate that Germes is a novel germ plasm-specific RNA. RLID00012447 398520 LOC398520 http://www.ncbi.nlm.nih.gov/gene/?term=398520 mRNA Xenopus laevis 12915321 Germ plasm Oocyte In situ hybridization In situ hybridization analysis shows that Germes transcript localizes to the vegetal cortex via the mitochondrial cloud early in oogenesis and segregates with the germ plasm during early embryogenesis. Our data indicate that Germes is a novel germ plasm-specific RNA. RLID00012448 398520 LOC398520 http://www.ncbi.nlm.nih.gov/gene/?term=398520 mRNA Xenopus laevis 12915321 Vegetal Oocyte In situ hybridization In situ hybridization analysis shows that Germes transcript localizes to the vegetal cortex via the mitochondrial cloud early in oogenesis and segregates with the germ plasm during early embryogenesis. Our data indicate that Germes is a novel germ plasm-specific RNA. RLID00012449 3985 LIMK2 http://www.ncbi.nlm.nih.gov/gene/?term=3985 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012450 398655 velo1 http://www.ncbi.nlm.nih.gov/gene/?term=398655 Xvelo1 mRNA Xenopus laevis 23626739 Germ plasm Oocyte Microscopy "Xpat is a germ plasm RNA whose protein is also present in germ plasm, in particles which we show here are distinct from those containing Hermes protein and the various germ plasm RNAs tested, including that encoding Xpat itself " RLID00012451 398655 velo1 http://www.ncbi.nlm.nih.gov/gene/?term=398655 Xvelo1 mRNA Xenopus laevis 23626739 Germ plasm Oocyte Microscopy "We find that in mid oogenesis nanos1 RNA also localises to germ plasm but also by the late pathway. Late pathway RNAs,Vg1 and VegT, also may localise into germ plasm. " RLID00012452 39871 Dbp73D http://www.ncbi.nlm.nih.gov/gene/?term=39871 "Dmel_CG9680, CG9680, DBP73D, DmRH7, Dmel\CG9680 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012453 39871 Dbp73D http://www.ncbi.nlm.nih.gov/gene/?term=39871 "Dmel_CG9680, CG9680, DBP73D, DmRH7, Dmel\CG9680 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012454 39877 Int6 http://www.ncbi.nlm.nih.gov/gene/?term=39877 "Dmel_CG9677, BcDNA.GM01233, BcDNA:GM01233, CG9677, DINT6, Dmel\CG9677, eIF-3p48/INT-6, eIF3-S6, eIF3-p48/INT6, eIF3e, l(3)10547, l(3)j9E8 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012455 3987 LIMS1 http://www.ncbi.nlm.nih.gov/gene/?term=3987 "PINCH, PINCH-1, PINCH1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012456 398800 dgat2 http://www.ncbi.nlm.nih.gov/gene/?term=398800 mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00012457 398805 exd2 http://www.ncbi.nlm.nih.gov/gene/?term=398805 "exd2-a, exdl2 " mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00012458 3988 LIPA http://www.ncbi.nlm.nih.gov/gene/?term=3988 "CESD, LAL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012459 3988 LIPA http://www.ncbi.nlm.nih.gov/gene/?term=3988 "CESD, LAL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012460 398948 rbpms http://www.ncbi.nlm.nih.gov/gene/?term=398948 hermes mRNA Xenopus laevis 14975717 Vegetal Oocyte In situ hybridization "Hermes mRNA and protein are both detected at the vegetal cortex of the oocyte; however, the protein is degraded within a several hour period during oocyte maturation. " RLID00012461 398948 rbpms http://www.ncbi.nlm.nih.gov/gene/?term=398948 hermes mRNA Xenopus laevis 23626739 Germ plasm Oocyte Microscopy "In addition to the Balbiani body, Hermes RNA is localised in germ plasm particles in the vegetal cortex of vitellogenic oocytes. " RLID00012462 398948 rbpms http://www.ncbi.nlm.nih.gov/gene/?term=398948 hermes mRNA Xenopus laevis 23626739 Mitochondrion Oocyte Microscopy "In addition to the Balbiani body, Hermes RNA is localised in germ plasm particles in the vegetal cortex of vitellogenic oocytes. " RLID00012463 398948 rbpms http://www.ncbi.nlm.nih.gov/gene/?term=398948 hermes mRNA Xenopus laevis 23626739 Vegetal Oocyte Microscopy "In addition to the Balbiani body, Hermes RNA is localised in germ plasm particles in the vegetal cortex of vitellogenic oocytes. " RLID00012464 399008 smtn-a http://www.ncbi.nlm.nih.gov/gene/?term=399008 smtn mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00012465 3990 LIPC http://www.ncbi.nlm.nih.gov/gene/?term=3990 "HDLCQ12, HL, HTGL, LIPH " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012466 399101 Snhg3 http://www.ncbi.nlm.nih.gov/gene/?term=399101 "Rnu17d, U17HG " lncRNA Mus musculus 25332394 Cytoplasm - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/snhg3/ RLID00012467 399101 Snhg3 http://www.ncbi.nlm.nih.gov/gene/?term=399101 "Rnu17d, U17HG " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012468 399106 bub3 http://www.ncbi.nlm.nih.gov/gene/?term=399106 xbub3 mRNA Xenopus laevis 11081630 Mitotic spindle Embryo Whole mount In Situ Hybridization Xbub3 and Cyclin B1 mRNAs are concentrated on the mitotic apparatus. RLID00012469 3991 LIPE http://www.ncbi.nlm.nih.gov/gene/?term=3991 "AOMS4, FPLD6, HSL, LHS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012470 399289 cpeb1-a http://www.ncbi.nlm.nih.gov/gene/?term=399289 "CPEB, cpeb1 " mRNA Xenopus laevis 11081630 Mitotic spindle Embryo Whole mount In Situ Hybridization "CPEB, Maskin, and Cyclin B1 mRNA at the mitotic apparatus: implications for local translational control of cell division. " RLID00012471 3992 FADS1 http://www.ncbi.nlm.nih.gov/gene/?term=3992 "D5D, FADS6, FADSD5, LLCDL1, TU12 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012472 3992 FADS1 http://www.ncbi.nlm.nih.gov/gene/?term=3992 "D5D, FADS6, FADSD5, LLCDL1, TU12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012473 3992 FADS1 http://www.ncbi.nlm.nih.gov/gene/?term=3992 "D5D, FADS6, FADSD5, LLCDL1, TU12 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012474 39933 Mip http://www.ncbi.nlm.nih.gov/gene/?term=39933 "Dmel_CG6456, ASB, AST-B, Ast-B, AstB, AstB-1, CG6456, DAP-B, DmMIP1, DmMIP2, DmMIP3, DmMIP4, DmMIP5, Dmel\CG6456, Drm-MIP, Drm-MIP-1, Drm-MIP-2, Drm-MIP-3, Drm-MIP-4, Drm-MIP-5, MIP, MIP-1, MIP-2, MIP-3, MIP-4, MIP-5, mip " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012475 39933 Mip http://www.ncbi.nlm.nih.gov/gene/?term=39933 "Dmel_CG6456, ASB, AST-B, Ast-B, AstB, AstB-1, CG6456, DAP-B, DmMIP1, DmMIP2, DmMIP3, DmMIP4, DmMIP5, Dmel\CG6456, Drm-MIP, Drm-MIP-1, Drm-MIP-2, Drm-MIP-3, Drm-MIP-4, Drm-MIP-5, MIP, MIP-1, MIP-2, MIP-3, MIP-4, MIP-5, mip " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012476 399353 tob2 http://www.ncbi.nlm.nih.gov/gene/?term=399353 "tob4, tobl, trob2 " mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00012477 39936 Cad74A http://www.ncbi.nlm.nih.gov/gene/?term=39936 "Dmel_CG6445, CG6445, CT20086, Cad74B, DCad74B, Dmel\CG6445, cad74A " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012478 39936 Cad74A http://www.ncbi.nlm.nih.gov/gene/?term=39936 "Dmel_CG6445, CG6445, CT20086, Cad74B, DCad74B, Dmel\CG6445, cad74A " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012479 39936 Cad74A http://www.ncbi.nlm.nih.gov/gene/?term=39936 "Dmel_CG6445, CG6445, CT20086, Cad74B, DCad74B, Dmel\CG6445, cad74A " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012480 3993 LLGL2 http://www.ncbi.nlm.nih.gov/gene/?term=3993 "HGL, Hugl-2, LGL2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012481 3993 LLGL2 http://www.ncbi.nlm.nih.gov/gene/?term=3993 "HGL, Hugl-2, LGL2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012482 399441 wnt11b http://www.ncbi.nlm.nih.gov/gene/?term=399441 "WNT11, wnt-11, xwnt11 " mRNA Xenopus laevis 7539356 Mitochondrion Oocyte In situ hybridization "One of these, through which Xlsirts, Xcat2 and Xwnt11 are localized, involves transport during stages 1 and 2 of oogenesis via a region of the mitochondrial cloud that we call the message transport organizer or METRO. This pathway involved three steps, transport of RNA from the GV to the mitochondrial cloud, sorting of the RNAs to specific regions of the METRO, and translocation to and anchoring at the vegetal cortex. " RLID00012483 399441 wnt11b http://www.ncbi.nlm.nih.gov/gene/?term=399441 "WNT11, wnt-11, xwnt11 " mRNA Xenopus laevis 8948579 Mitochondrion Oocyte In situ hybridization "In the present study we analyzed the properties of the METRO pathway, which localizes Xlsirt, Xcat2, and Xwnt11 RNAs to a specific region of the vegetal cortex during stage 1 of oogenesis. A combination of methodologies involving both fixed material and living oocytes was used to analyze RNA localization. We show that in early diplotene pre-stage 1 oocytes (25-50 microm in diameter) both endogenous and injected exogenous METRO RNAs translocated to multiple mitochondrial aggregates (pre-mitochondrial clouds) that surround the germinal vesicle (GV). However, by early stage 1 (diplotene oocytes, 50-200 microm), all three of the RNAs discriminated between the different clouds and translocated exclusively within the METRO of a single mitochondrial cloud. " RLID00012484 399441 wnt11b http://www.ncbi.nlm.nih.gov/gene/?term=399441 "WNT11, wnt-11, xwnt11 " mRNA Xenopus laevis 8948579 Vegetal Oocyte In situ hybridization "In the present study we analyzed the properties of the METRO pathway, which localizes Xlsirt, Xcat2, and Xwnt11 RNAs to a specific region of the vegetal cortex during stage 1 of oogenesis. A combination of methodologies involving both fixed material and living oocytes was used to analyze RNA localization. We show that in early diplotene pre-stage 1 oocytes (25-50 microm in diameter) both endogenous and injected exogenous METRO RNAs translocated to multiple mitochondrial aggregates (pre-mitochondrial clouds) that surround the germinal vesicle (GV). However, by early stage 1 (diplotene oocytes, 50-200 microm), all three of the RNAs discriminated between the different clouds and translocated exclusively within the METRO of a single mitochondrial cloud. " RLID00012485 399441 wnt11b http://www.ncbi.nlm.nih.gov/gene/?term=399441 "WNT11, wnt-11, xwnt11 " mRNA Xenopus laevis 9739112 Vegetal Oocyte In situ hybridization "We focused on Xlsirts, Xcat2, and Xwnt11 transcripts that are localized to the vegetal cortex through a region of the mitochondrial cloud called the messenger transport organizer (METRO) that also contains the nuage or germ plasm. At the ultrastructural level Xcat2 mRNA was detected on germinal granules while Xlsirts and Xwnt11 were associated with a fibrillar network of the germ plasm in stage-1 and stage-4 oocytes. " RLID00012486 399441 wnt11b http://www.ncbi.nlm.nih.gov/gene/?term=399441 "WNT11, wnt-11, xwnt11 " mRNA Xenopus laevis 9739112 Mitochondrion Oocyte In situ hybridization "We focused on Xlsirts, Xcat2, and Xwnt11 transcripts that are localized to the vegetal cortex through a region of the mitochondrial cloud called the messenger transport organizer (METRO) that also contains the nuage or germ plasm. At the ultrastructural level Xcat2 mRNA was detected on germinal granules while Xlsirts and Xwnt11 were associated with a fibrillar network of the germ plasm in stage-1 and stage-4 oocytes. " RLID00012487 399441 wnt11b http://www.ncbi.nlm.nih.gov/gene/?term=399441 "WNT11, wnt-11, xwnt11 " mRNA Xenopus laevis 9739112 Germ plasm Oocyte In situ hybridization "We focused on Xlsirts, Xcat2, and Xwnt11 transcripts that are localized to the vegetal cortex through a region of the mitochondrial cloud called the messenger transport organizer (METRO) that also contains the nuage or germ plasm. At the ultrastructural level Xcat2 mRNA was detected on germinal granules while Xlsirts and Xwnt11 were associated with a fibrillar network of the germ plasm in stage-1 and stage-4 oocytes. " RLID00012488 399441 wnt11b http://www.ncbi.nlm.nih.gov/gene/?term=399441 "WNT11, wnt-11, xwnt11 " mRNA Xenopus laevis 11309203 Vegetal Oocyte In situ hybridization "The IVC retained mRNAs with a granular texture, and their distribution patterns resembled those of the whole oocyte. Vg1 was distributed in the entire cortex, whereas Xwnt-11 and Xcat-2 were both concentrated as a disc at the vegetal pole. " RLID00012489 399441 wnt11b http://www.ncbi.nlm.nih.gov/gene/?term=399441 "WNT11, wnt-11, xwnt11 " mRNA Xenopus laevis 11784096 Germ plasm Oocyte In situ hybridization "The germ plasm is a specialized region of oocyte cytoplasm that contains determinants of germ cell fate. In Xenopus oocytes, the germ plasm is a part of the METRO region of mitochondrial cloud. It contains the germinal granules and a variety of coding and noncoding RNAs that include Xcat2, Xlsirts, Xdazl, DEADSouth, Xpat, Xwnt11, fatVg, B7/Fingers, C10/XFACS, and mitochondrial large and small rRNA. We analyzed the distribution of these 11 different RNAs within the various compartments of germ plasm during Xenopus oogenesis and development by using whole-mount electron microscopy in situ hybridization. " RLID00012490 399441 wnt11b http://www.ncbi.nlm.nih.gov/gene/?term=399441 "WNT11, wnt-11, xwnt11 " mRNA Xenopus laevis 19223445 Mitochondrion Oocyte Quantitative RNA localization assay "Early RNAs, such as Xcat-2, Xlsirt, and Xwnt, become localized to a large subcellular structure called the Balbiani body or mitochondrial cloud. " RLID00012491 39958 Nedd4 http://www.ncbi.nlm.nih.gov/gene/?term=39958 "Dmel_CG42279, ACN62428.1, CG32184, CG42279, CG7555, D Dmel\CG42279, Dmel_CG32184, Dmel_CG7555, NEDD4, dNedd4, dNedd4-1, nedd4 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012492 3995 FADS3 http://www.ncbi.nlm.nih.gov/gene/?term=3995 "CYB5RP, LLCDL3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012493 3995 FADS3 http://www.ncbi.nlm.nih.gov/gene/?term=3995 "CYB5RP, LLCDL3 " mRNA Homo sapiens 22679391 Endoplasmic reticulum U2OS cell RT-PCR "Figure 3B: The levels of several transcripts in the ER fraction were analyzed as in (A). Measured transcripts include those encoding ER luminal proteins (BiP, Calreticulin), ER membrane proteins (Inositol-3-phosphate Receptor (IP3 Receptor), Sec61α, Trapα, and Fatty Acid Desaturase 3 (FADS3)), a Golgi protein (Mannosidase 2A (Man2A)), plasma membrane proteins (Integrin β1, and Transferrin Receptor (Tf Receptor)), and a secreted protein (Interleukin 7 (IL7)). All measurements were standardized to the level of mRNA in the ER fraction from control cells. Data are collected from Figure 3B. " RLID00012494 399664 MEX3D http://www.ncbi.nlm.nih.gov/gene/?term=399664 "MEX-3D, MEX3, OK/SW-cl.4, RKHD1, RNF193, TINO " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012495 399671 HEATR4 http://www.ncbi.nlm.nih.gov/gene/?term=399671 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012496 3996 LLGL1 http://www.ncbi.nlm.nih.gov/gene/?term=3996 "DLG4, HUGL, HUGL-1, HUGL1, LLGL, Lgl1, Mgl1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012497 3996 LLGL1 http://www.ncbi.nlm.nih.gov/gene/?term=3996 "DLG4, HUGL, HUGL-1, HUGL1, LLGL, Lgl1, Mgl1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012498 3996 LLGL1 http://www.ncbi.nlm.nih.gov/gene/?term=3996 "DLG4, HUGL, HUGL-1, HUGL1, LLGL, Lgl1, Mgl1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012499 3996 LLGL1 http://www.ncbi.nlm.nih.gov/gene/?term=3996 "DLG4, HUGL, HUGL-1, HUGL1, LLGL, Lgl1, Mgl1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012500 3996 LLGL1 http://www.ncbi.nlm.nih.gov/gene/?term=3996 "DLG4, HUGL, HUGL-1, HUGL1, LLGL, Lgl1, Mgl1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012501 39976 Adgf-A http://www.ncbi.nlm.nih.gov/gene/?term=39976 "Dmel_CG5992, ADGDF-A, ADGF-A, Adgf-a, AdgfA, CG5992, Dmel\CG5992, adgf-a, adgfa " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012502 3998 LMAN1 http://www.ncbi.nlm.nih.gov/gene/?term=3998 "ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012503 3998 LMAN1 http://www.ncbi.nlm.nih.gov/gene/?term=3998 "ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012504 3998 LMAN1 http://www.ncbi.nlm.nih.gov/gene/?term=3998 "ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012505 399909 PCNX3 http://www.ncbi.nlm.nih.gov/gene/?term=399909 PCNXL3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012506 399948 COLCA1 http://www.ncbi.nlm.nih.gov/gene/?term=399948 "C11orf92, CASC12, LOH11CR1F " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012507 399948 COLCA1 http://www.ncbi.nlm.nih.gov/gene/?term=399948 "C11orf92, CASC12, LOH11CR1F " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012508 399949 C11orf88 http://www.ncbi.nlm.nih.gov/gene/?term=399949 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012509 399959 MIR100HG http://www.ncbi.nlm.nih.gov/gene/?term=399959 "AGD1, lncRNA-N2 " lncRNA Homo sapiens 22193719 Cytoplasm Embryonic stem cell qRT-PCR|Microarray "Figure 7: Neuronal lncRNAs act via diverse mechanisms. (A) Quantification of relative expression of lncRNAs in nuclear and cytoplasmic cell fractions. (B) Quantification of changes in hosted miRNAs in response to lncRNA_N2 knockdown. MiRNAs were quantified using Taqman miRNA qPCR. (C-E) RIP of lncRNAs with SUZ12 and REST antibodies. The interaction of HOTAIR with SUZ12 is a known interaction that serves as a positive control (Gupta et al, 2010). * and ** indicate P-values of <0.05 and <0.01, respectively. Data are collected from Figure 7. " RLID00012510 39995 Tsp74F http://www.ncbi.nlm.nih.gov/gene/?term=39995 "Dmel_CG5492, CG5492, Dm.Tsp74F, Dmel\CG5492 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012511 399979 SNX19 http://www.ncbi.nlm.nih.gov/gene/?term=399979 CHET8 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012512 399979 SNX19 http://www.ncbi.nlm.nih.gov/gene/?term=399979 CHET8 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012513 399 RHOH http://www.ncbi.nlm.nih.gov/gene/?term=399 "ARHH, TTF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012514 39 ACAT2 http://www.ncbi.nlm.nih.gov/gene/?term=39 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012515 39 ACAT2 http://www.ncbi.nlm.nih.gov/gene/?term=39 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012516 39 ACAT2 http://www.ncbi.nlm.nih.gov/gene/?term=39 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012517 400073 C12orf76 http://www.ncbi.nlm.nih.gov/gene/?term=400073 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012518 4000 LMNA http://www.ncbi.nlm.nih.gov/gene/?term=4000 "CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012519 4000 LMNA http://www.ncbi.nlm.nih.gov/gene/?term=4000 "CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012520 4001 LMNB1 http://www.ncbi.nlm.nih.gov/gene/?term=4001 "ADLD, LMN, LMN2, LMNB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012521 40021 CG7271 http://www.ncbi.nlm.nih.gov/gene/?term=40021 Dmel_ Dmel\CG7271 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012522 400410 ST20 http://www.ncbi.nlm.nih.gov/gene/?term=400410 HCCS-1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012523 400410 ST20 http://www.ncbi.nlm.nih.gov/gene/?term=400410 HCCS-1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012524 400451 FAM174B http://www.ncbi.nlm.nih.gov/gene/?term=400451 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012525 400506 KNOP1 http://www.ncbi.nlm.nih.gov/gene/?term=400506 "101F10.1, C16orf88, FAM191A, TSG118 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012526 400550 FENDRR http://www.ncbi.nlm.nih.gov/gene/?term=400550 "FOXF1-AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21 " lncRNA Homo sapiens 19571010 Nucleus HFF|HLF|HeLa cell Fluorescence in situ hybridization "Figure 3b: Subcellular localization analysis of lincRNAs by RNA FISH demonstrates localization of lincRNAs to the nucleus. Each panel represents the in situ hybridization of â‰?0 fluorescently labeled DNA oligos with complementarity to the interrogated lincRNA. RNA FISH experiments were performed in male hFF for each represented lincRNA (XIST, HOTAIR, TUG-1, lincMKLN-1, lincFOXF1, and lincSFPQ), and also in female hLF for XIST (XX). White “specklesâ€?indicate the subcellular localization of each lincRNA. The nuclear compartment is demarked by DAPI staining (purple). " RLID00012527 400550 FENDRR http://www.ncbi.nlm.nih.gov/gene/?term=400550 "FOXF1-AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21 " lncRNA Homo sapiens 25630241 Cytoplasm Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00012528 400550 FENDRR http://www.ncbi.nlm.nih.gov/gene/?term=400550 "FOXF1-AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21 " lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00012529 400550 FENDRR http://www.ncbi.nlm.nih.gov/gene/?term=400550 "FOXF1-AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21 " lncRNA Homo sapiens 25630241 Nucleus Hela cell qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00012530 400550 FENDRR http://www.ncbi.nlm.nih.gov/gene/?term=400550 "FOXF1-AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21 " lncRNA Homo sapiens 25630241 Nucleus Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00012531 400550 FENDRR http://www.ncbi.nlm.nih.gov/gene/?term=400550 "FOXF1-AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21 " lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00012532 400550 FENDRR http://www.ncbi.nlm.nih.gov/gene/?term=400550 "FOXF1-AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21 " lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00012533 400569 MED11 http://www.ncbi.nlm.nih.gov/gene/?term=400569 HSPC296 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012534 4005 LMO2 http://www.ncbi.nlm.nih.gov/gene/?term=4005 "RBTN2, RBTNL1, RHOM2, TTG2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012535 400619 LINC00511 http://www.ncbi.nlm.nih.gov/gene/?term=400619 "LCAL5, onco-lncRNA-12 " lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012536 40061 arx http://www.ncbi.nlm.nih.gov/gene/?term=40061 "Dmel_CG3893, BcDNA:LD18018, CG3893, DmGTSF1, Dmel\CG3893, Gtsf1 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012537 400713 ZNF880 http://www.ncbi.nlm.nih.gov/gene/?term=400713 mRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00012538 400720 ZNF772 http://www.ncbi.nlm.nih.gov/gene/?term=400720 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012539 400720 ZNF772 http://www.ncbi.nlm.nih.gov/gene/?term=400720 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012540 400745 SH2D5 http://www.ncbi.nlm.nih.gov/gene/?term=400745 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012541 40080 CG6812 http://www.ncbi.nlm.nih.gov/gene/?term=40080 Dmel_ Dmel\CG6812 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012542 4008 LMO7 http://www.ncbi.nlm.nih.gov/gene/?term=4008 "FBX20, FBXO20, LOMP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012543 4008 LMO7 http://www.ncbi.nlm.nih.gov/gene/?term=4008 "FBX20, FBXO20, LOMP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012544 400916 CHCHD10 http://www.ncbi.nlm.nih.gov/gene/?term=400916 "C22orf16, FTDALS2, IMMD, N27C7-4, SMAJ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012545 400931 MIRLET7BHG http://www.ncbi.nlm.nih.gov/gene/?term=400931 linc-Ppara mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012546 40095 Max http://www.ncbi.nlm.nih.gov/gene/?term=40095 "Dmel_CG9648, CG9648, Dmel\CG9648, MAX, bHLHd9, d dmax, max " mRNA Drosophila melanogaster 17923096 Nucleus Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00012547 400960 PCBP1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=400960 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012548 400961 PAIP2B http://www.ncbi.nlm.nih.gov/gene/?term=400961 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012549 400961 PAIP2B http://www.ncbi.nlm.nih.gov/gene/?term=400961 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012550 400961 PAIP2B http://www.ncbi.nlm.nih.gov/gene/?term=400961 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012551 40096 CG9666 http://www.ncbi.nlm.nih.gov/gene/?term=40096 "Dmel_ Dmel\CG9666, Dromel_CG9666_FBtr0074991_mORF " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012552 400 ARL1 http://www.ncbi.nlm.nih.gov/gene/?term=400 ARFL1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012553 400 ARL1 http://www.ncbi.nlm.nih.gov/gene/?term=400 ARFL1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012554 40104 pip http://www.ncbi.nlm.nih.gov/gene/?term=40104 "Dmel_CG9614, CG9614, Dmel\CG9614, Pipe, l(3)76BDpe-ST2, pip " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012555 401089 FOXL2NB http://www.ncbi.nlm.nih.gov/gene/?term=401089 C3orf72 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012556 401089 FOXL2NB http://www.ncbi.nlm.nih.gov/gene/?term=401089 C3orf72 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012557 4010 LMX1B http://www.ncbi.nlm.nih.gov/gene/?term=4010 "LMX1.2, NPS1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012558 4010 LMX1B http://www.ncbi.nlm.nih.gov/gene/?term=4010 "LMX1.2, NPS1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012559 4010 LMX1B http://www.ncbi.nlm.nih.gov/gene/?term=4010 "LMX1.2, NPS1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012560 401115 C4orf48 http://www.ncbi.nlm.nih.gov/gene/?term=401115 CHR4_55 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012561 401152 C4orf3 http://www.ncbi.nlm.nih.gov/gene/?term=401152 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012562 401152 C4orf3 http://www.ncbi.nlm.nih.gov/gene/?term=401152 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012563 401242 LINC01623 http://www.ncbi.nlm.nih.gov/gene/?term=401242 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012564 401251 SAPCD1 http://www.ncbi.nlm.nih.gov/gene/?term=401251 "C6orf26, NG23 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012565 401262 CRIP3 http://www.ncbi.nlm.nih.gov/gene/?term=401262 "TLP, TLP-A, bA480N24.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012566 4012 LNPEP http://www.ncbi.nlm.nih.gov/gene/?term=4012 "CAP, IRAP, P-LAP, PLAP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012567 4012 LNPEP http://www.ncbi.nlm.nih.gov/gene/?term=4012 "CAP, IRAP, P-LAP, PLAP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012568 401397 LINC00998 http://www.ncbi.nlm.nih.gov/gene/?term=401397 lncRNA Homo sapiens 25630241 Cytoplasm Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00012569 401466 C8orf59 http://www.ncbi.nlm.nih.gov/gene/?term=401466 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012570 40146 tey http://www.ncbi.nlm.nih.gov/gene/?term=40146 "Dmel_CG8780, CG8780, Dmel\CG8780 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012571 401474 SAMD12 http://www.ncbi.nlm.nih.gov/gene/?term=401474 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012572 401505 TOMM5 http://www.ncbi.nlm.nih.gov/gene/?term=401505 "C9orf105, Tom5, bA613M10.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012573 401548 SNX30 http://www.ncbi.nlm.nih.gov/gene/?term=401548 ATG24A mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012574 401588 ZNF674-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=401588 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012575 4015 LOX http://www.ncbi.nlm.nih.gov/gene/?term=4015 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012576 4015 LOX http://www.ncbi.nlm.nih.gov/gene/?term=4015 mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00012577 401612 SLC25A53 http://www.ncbi.nlm.nih.gov/gene/?term=401612 MCART6 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012578 401612 SLC25A53 http://www.ncbi.nlm.nih.gov/gene/?term=401612 MCART6 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012579 401647 GOLGA7B http://www.ncbi.nlm.nih.gov/gene/?term=401647 "C10orf132, C10orf133, bA451M19.3, bA459F3.4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012580 40179 RhoGDI http://www.ncbi.nlm.nih.gov/gene/?term=40179 "Dmel_CG7823, CG7823, Dmel\CG7823 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012581 40179 RhoGDI http://www.ncbi.nlm.nih.gov/gene/?term=40179 "Dmel_CG7823, CG7823, Dmel\CG7823 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012582 402055 SRRD http://www.ncbi.nlm.nih.gov/gene/?term=402055 "HC/HCC, SRR1L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012583 40232 polo http://www.ncbi.nlm.nih.gov/gene/?term=40232 "Dmel_CG12306, 0256/04, 1324/08, CG12306, Dmel\CG12306, PLK1, POLO, POLO/PLK1, Polo, Polo kinase, anon-WO0172774.3, l(3)01673, l(3)77Aa, l(3)S025604, l(3)S132408 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012584 402381 SOHLH1 http://www.ncbi.nlm.nih.gov/gene/?term=402381 "C9orf157, NOHLH, SPATA27, TEB2, bA100C15.3, bHLHe80 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012585 4023 LPL http://www.ncbi.nlm.nih.gov/gene/?term=4023 "HDLCQ11, LIPD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012586 40249 RhoBTB http://www.ncbi.nlm.nih.gov/gene/?term=40249 "Dmel_CG5701, 28574635, CG5701, Dmel\CG5701, RhoGTPase, RhoX " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012587 40249 RhoBTB http://www.ncbi.nlm.nih.gov/gene/?term=40249 "Dmel_CG5701, 28574635, CG5701, Dmel\CG5701, RhoGTPase, RhoX " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012588 40252 CG33969 http://www.ncbi.nlm.nih.gov/gene/?term=40252 "Dmel_ CG32429, CG5571, Dmel\CG33969 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012589 40252 CG33969 http://www.ncbi.nlm.nih.gov/gene/?term=40252 "Dmel_ CG32429, CG5571, Dmel\CG33969 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012590 402665 IGLON5 http://www.ncbi.nlm.nih.gov/gene/?term=402665 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012591 4026 LPP http://www.ncbi.nlm.nih.gov/gene/?term=4026 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012592 4026 LPP http://www.ncbi.nlm.nih.gov/gene/?term=4026 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012593 4026 LPP http://www.ncbi.nlm.nih.gov/gene/?term=4026 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012594 40283 Rcd2 http://www.ncbi.nlm.nih.gov/gene/?term=40283 "Dmel_CG4786, CG4786, CT15369, Dmel\CG4786 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012595 40289 CG13252 http://www.ncbi.nlm.nih.gov/gene/?term=40289 Dmel_ Dmel\CG13252 mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012596 402 ARL2 http://www.ncbi.nlm.nih.gov/gene/?term=402 ARFL2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012597 402 ARL2 http://www.ncbi.nlm.nih.gov/gene/?term=402 ARFL2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012598 40314 fng http://www.ncbi.nlm.nih.gov/gene/?term=40314 "Dmel_CG10580, CG10580, D-Fng, D-fng, Dfng, Dmel\CG10580, Fng, Frg, fg, frg, l(3)rG554 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012599 40314 fng http://www.ncbi.nlm.nih.gov/gene/?term=40314 "Dmel_CG10580, CG10580, D-Fng, D-fng, Dfng, Dmel\CG10580, Fng, Frg, fg, frg, l(3)rG554 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012600 403187 Opa3 http://www.ncbi.nlm.nih.gov/gene/?term=403187 "D630048P19Rik, Gm1425, Gm472 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012601 40327 siz http://www.ncbi.nlm.nih.gov/gene/?term=40327 "Dmel_CG32434, CG10577, CG12980, CG12981, CG32434, Dmel\CG32434, Loner, loner " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012602 403313 PLPP6 http://www.ncbi.nlm.nih.gov/gene/?term=403313 "PDP1, PPAPDC2, PSDP, bA6J24.6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012603 4033 LRMP http://www.ncbi.nlm.nih.gov/gene/?term=4033 JAW1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012604 403521 TPO http://www.ncbi.nlm.nih.gov/gene/?term=403521 mRNA Canis lupus familiaris 8269983 Nucleus Thyroid epithelial cell In situ hybridization "As compared to another thyroid differentiation marker, thyroglobulin mRNA (Pohl et al., J. Cell Biol. 111, 663-672 (1990)), TPO mRNA accumulation differed by the rapidity of its control by cAMP, the pattern of its intercellular heterogeneity, and the unexpected segregation to a perinuclear region, probably the nuclear envelope that constitutes a specialized part of the endoplasmic reticulum. " RLID00012605 403536 TPMT http://www.ncbi.nlm.nih.gov/gene/?term=403536 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00012606 4035 LRP1 http://www.ncbi.nlm.nih.gov/gene/?term=4035 "A2MR, APOER, APR, CD91, IGFBP3R, LRPA, TGFBR5, LRP1 " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00012607 403647 SGK1 http://www.ncbi.nlm.nih.gov/gene/?term=403647 SGK mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00012608 403680 RPL13A http://www.ncbi.nlm.nih.gov/gene/?term=403680 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00012609 403682 RPL19 http://www.ncbi.nlm.nih.gov/gene/?term=403682 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00012610 40368 rgn http://www.ncbi.nlm.nih.gov/gene/?term=40368 "Dmel_CG6014, BcDNA:GH11973, CG6014, Dmel\CG6014, l(3)00534 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012611 40368 rgn http://www.ncbi.nlm.nih.gov/gene/?term=40368 "Dmel_CG6014, BcDNA:GH11973, CG6014, Dmel\CG6014, l(3)00534 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012612 403726 RPGR http://www.ncbi.nlm.nih.gov/gene/?term=403726 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00012613 4037 LRP3 http://www.ncbi.nlm.nih.gov/gene/?term=4037 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012614 403845 FN1 http://www.ncbi.nlm.nih.gov/gene/?term=403845 FN mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell In situ hybridization Figure 5: Validation and expression of pseudopodial enriched mRNAs and gene products. Data are collected from Figur 5. RLID00012615 403856 MAPK14 http://www.ncbi.nlm.nih.gov/gene/?term=403856 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00012616 403857 FGF2 http://www.ncbi.nlm.nih.gov/gene/?term=403857 BFGF mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00012617 403871 KRAS http://www.ncbi.nlm.nih.gov/gene/?term=403871 K-RAS mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00012618 40389 VhaM9.7-b http://www.ncbi.nlm.nih.gov/gene/?term=40389 "Dmel_CG7625, ATP6V0M9.7-2, CG7625, Dmel\CG7625, Vha M9.7-2, VhaM9.7-2, anon-WO0118547.551, vhaM9.2-2, vhaM9.7-2, vhaM9.7-b " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012619 40395 CRIF http://www.ncbi.nlm.nih.gov/gene/?term=40395 "Dmel_CG7172, CG7172, Dmel\CG7172, anon-WO0118547.316, dCRIF " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012620 403 ARL3 http://www.ncbi.nlm.nih.gov/gene/?term=403 ARFL3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012621 404037 HAPLN4 http://www.ncbi.nlm.nih.gov/gene/?term=404037 BRAL2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012622 404093 CUEDC1 http://www.ncbi.nlm.nih.gov/gene/?term=404093 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012623 4040 LRP6 http://www.ncbi.nlm.nih.gov/gene/?term=4040 "ADCAD2, STHAG7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012624 4040 LRP6 http://www.ncbi.nlm.nih.gov/gene/?term=4040 "ADCAD2, STHAG7 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012625 4041 LRP5 http://www.ncbi.nlm.nih.gov/gene/?term=4041 "BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012626 4041 LRP5 http://www.ncbi.nlm.nih.gov/gene/?term=4041 "BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012627 404323 Olfr1040 http://www.ncbi.nlm.nih.gov/gene/?term=404323 MOR185-12 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012628 4043 LRPAP1 http://www.ncbi.nlm.nih.gov/gene/?term=4043 "A2MRAP, A2RAP, HBP44, MRAP, MYP23, RAP, alpha-2-MRAP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012629 4043 LRPAP1 http://www.ncbi.nlm.nih.gov/gene/?term=4043 "A2MRAP, A2RAP, HBP44, MRAP, MYP23, RAP, alpha-2-MRAP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012630 404636 FAM45A http://www.ncbi.nlm.nih.gov/gene/?term=404636 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012631 404672 GTF2H5 http://www.ncbi.nlm.nih.gov/gene/?term=404672 "C6orf175, TFB5, TFIIH, TGF2H5, TTD, TTD-A, TTD3, TTDA, bA120J8.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012632 404672 GTF2H5 http://www.ncbi.nlm.nih.gov/gene/?term=404672 "C6orf175, TFB5, TFIIH, TGF2H5, TTD, TTD-A, TTD3, TTDA, bA120J8.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012633 4047 LSS http://www.ncbi.nlm.nih.gov/gene/?term=4047 "CTRCT44, OSC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012634 4047 LSS http://www.ncbi.nlm.nih.gov/gene/?term=4047 "CTRCT44, OSC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012635 40489 mael http://www.ncbi.nlm.nih.gov/gene/?term=40489 "Dmel_CG11254, CG11254, Dmel\CG11254, MAEL, Mael, mae1 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012636 4048 LTA4H http://www.ncbi.nlm.nih.gov/gene/?term=4048 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012637 4048 LTA4H http://www.ncbi.nlm.nih.gov/gene/?term=4048 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012638 4048 LTA4H http://www.ncbi.nlm.nih.gov/gene/?term=4048 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012639 4048 LTA4H http://www.ncbi.nlm.nih.gov/gene/?term=4048 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012640 40510 slif http://www.ncbi.nlm.nih.gov/gene/?term=40510 "Dmel_CG11128, CG11128, Dmel\CG11128, SlifA, slif " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012641 4052 LTBP1 http://www.ncbi.nlm.nih.gov/gene/?term=4052 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012642 40530 abs http://www.ncbi.nlm.nih.gov/gene/?term=40530 "Dmel_CG14637, ABS, CG14637, DmRH23, Dmel\CG14637, anon-WO0118547.315, l(3)00620, l(3)04505, l(3)06862, l(3)06863 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012643 40530 abs http://www.ncbi.nlm.nih.gov/gene/?term=40530 "Dmel_CG14637, ABS, CG14637, DmRH23, Dmel\CG14637, anon-WO0118547.315, l(3)00620, l(3)04505, l(3)06862, l(3)06863 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012644 40535 TwdlG http://www.ncbi.nlm.nih.gov/gene/?term=40535 "Dmel_CG14643, CG14643, Dmel\CG14643 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012645 40548 Skp2 http://www.ncbi.nlm.nih.gov/gene/?term=40548 "Dmel_CG9772, 153298_at, CG9772, Dmel\CG9772, FBXL1, SKP2, d " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012646 4054 LTBP3 http://www.ncbi.nlm.nih.gov/gene/?term=4054 "DASS, LTBP-3, LTBP2, STHAG6, pp6425 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012647 4054 LTBP3 http://www.ncbi.nlm.nih.gov/gene/?term=4054 "DASS, LTBP-3, LTBP2, STHAG6, pp6425 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012648 40554 tub http://www.ncbi.nlm.nih.gov/gene/?term=40554 "Dmel_CG10520, CG10520, Dmel\CG10520, Tube " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012649 4055 LTBR http://www.ncbi.nlm.nih.gov/gene/?term=4055 "CD18, D12S370, LT-BETA-R, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFR3, TNFRSF3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012650 40562 srl http://www.ncbi.nlm.nih.gov/gene/?term=40562 "Dmel_CG9809, CG 9809, CG9809, Dmel\CG9809, PGC-1, PGC-1-alpha, Spargel, Srl, cg9809, dPCG1alpha, dPGC, dPGC-1, dPGC1 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012651 40562 srl http://www.ncbi.nlm.nih.gov/gene/?term=40562 "Dmel_CG9809, CG 9809, CG9809, Dmel\CG9809, PGC-1, PGC-1-alpha, Spargel, Srl, cg9809, dPCG1alpha, dPGC, dPGC-1, dPGC1 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012652 405754 ERVFRD-1 http://www.ncbi.nlm.nih.gov/gene/?term=405754 "ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012653 40588 Nep2 http://www.ncbi.nlm.nih.gov/gene/?term=40588 "Dmel_CG9761, BcDNA:GH07643, CG9761, DmNEP2, Dmel\CG9761, NEP2, dNEP2, nep2 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012654 40598 Hus1-like http://www.ncbi.nlm.nih.gov/gene/?term=40598 "Dmel_CG2525, CG2525, DmHus1, Dmel\CG2525, Hus-1, Hus1, hus1 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012655 405 ARNT http://www.ncbi.nlm.nih.gov/gene/?term=405 "HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012656 40607 Gnf1 http://www.ncbi.nlm.nih.gov/gene/?term=40607 "Dmel_CG1119, CG1119, DmRFC1, Dmel\CG1119, GTF-1, Gnf-1, Gtf1, ONF-CAACAA, RF-C 140, RFC, RFC1, RfC, RfC140, dRF-Cp140, dRFC140, gnf1, gtf1, rfc1 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012657 4061 LY6E http://www.ncbi.nlm.nih.gov/gene/?term=4061 "RIG-E, RIGE, SCA-2, SCA2, TSA-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012658 4061 LY6E http://www.ncbi.nlm.nih.gov/gene/?term=4061 "RIG-E, RIGE, SCA-2, SCA2, TSA-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012659 40620 cno http://www.ncbi.nlm.nih.gov/gene/?term=40620 "Dmel_CG42312, AF-6, CG2534, CG31537, CG42312, Canoe, Cno, Dmel\CG42312, Dmel_CG2534, Dmel_CG31537, EC3-10, anon-WO0172774.47?, dlhA, lip, mis, cno " mRNA Drosophila melanogaster 17923096 Cell junction Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00012660 40620 cno http://www.ncbi.nlm.nih.gov/gene/?term=40620 "Dmel_CG42312, AF-6, CG2534, CG31537, CG42312, Canoe, Cno, Dmel\CG42312, Dmel_CG2534, Dmel_CG31537, EC3-10, anon-WO0172774.47?, dlhA, lip, mis, cno " mRNA Drosophila melanogaster 17923096 Cytoskeleton Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00012661 40659 Hcs http://www.ncbi.nlm.nih.gov/gene/?term=40659 "Dmel_CG14670, CG14670, Dmel\CG14670, HCS, HSC, NEST:bs27h05 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012662 4065 LY75 http://www.ncbi.nlm.nih.gov/gene/?term=4065 "CD205, CLEC13B, DEC-205, GP200-MR6, LY-75 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012663 4065 LY75 http://www.ncbi.nlm.nih.gov/gene/?term=4065 "CD205, CLEC13B, DEC-205, GP200-MR6, LY-75 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012664 4067 LYN http://www.ncbi.nlm.nih.gov/gene/?term=4067 "JTK8, p53Lyn, p56Lyn " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012665 4067 LYN http://www.ncbi.nlm.nih.gov/gene/?term=4067 "JTK8, p53Lyn, p56Lyn " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012666 4067 LYN http://www.ncbi.nlm.nih.gov/gene/?term=4067 "JTK8, p53Lyn, p56Lyn " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012667 40686 CG2911 http://www.ncbi.nlm.nih.gov/gene/?term=40686 Dmel_ Dmel\CG2911 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012668 40690 CG12171 http://www.ncbi.nlm.nih.gov/gene/?term=40690 "Dmel_ Dmel\CG12171, anon-WO0118547.83 " mRNA Drosophila melanogaster 25838129 Basal Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012669 4069 LYZ http://www.ncbi.nlm.nih.gov/gene/?term=4069 "LYZF1, LZM " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012670 4069 LYZ http://www.ncbi.nlm.nih.gov/gene/?term=4069 "LYZF1, LZM " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012671 4069 LYZ http://www.ncbi.nlm.nih.gov/gene/?term=4069 "LYZF1, LZM " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012672 406 ARNTL http://www.ncbi.nlm.nih.gov/gene/?term=406 "BMAL1, BMAL1c, JAP3, MOP3, PASD3, TIC, bHLHe5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012673 40707 CG2100 http://www.ncbi.nlm.nih.gov/gene/?term=40707 Dmel_ Dmel\CG2100 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012674 40708 CG1236 http://www.ncbi.nlm.nih.gov/gene/?term=40708 Dmel_ Dmel\CG1236 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012675 40709 Sym http://www.ncbi.nlm.nih.gov/gene/?term=40709 "Dmel_CG2097, CG2097, Dmel\CG2097p, dSymp, Sym " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012676 4070 TACSTD2 http://www.ncbi.nlm.nih.gov/gene/?term=4070 "EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012677 4071 TM4SF1 http://www.ncbi.nlm.nih.gov/gene/?term=4071 "H-L6, L6, M3S1, TAAL6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012678 40723 Hpr1 http://www.ncbi.nlm.nih.gov/gene/?term=40723 "Dmel_CG2031, CG2031, Dmel\CG2031, HPR1 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012679 4072 EPCAM http://www.ncbi.nlm.nih.gov/gene/?term=4072 "DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012680 4072 EPCAM http://www.ncbi.nlm.nih.gov/gene/?term=4072 "DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012681 40739 Rm62 http://www.ncbi.nlm.nih.gov/gene/?term=40739 "Dmel_CG10279, 4136, CG10279, DmRH8, Dmel\CG10279, Dmp68, Lip, RM62, dmP68, l(3)01086, l(3)j3D2, l(3)j3D5, l(3)rG338, l(3)s5196, p68, rm62 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012682 4074 M6PR http://www.ncbi.nlm.nih.gov/gene/?term=4074 "CD-M6PR, CD-MPR, MPR 46, MPR-46, MPR46, SMPR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012683 4074 M6PR http://www.ncbi.nlm.nih.gov/gene/?term=4074 "CD-M6PR, CD-MPR, MPR 46, MPR-46, MPR46, SMPR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012684 4076 CAPRIN1 http://www.ncbi.nlm.nih.gov/gene/?term=4076 "GPIAP1, GPIP137, GRIP137, M11S1, RNG105, p137GPI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012685 4076 CAPRIN1 http://www.ncbi.nlm.nih.gov/gene/?term=4076 "GPIAP1, GPIP137, GRIP137, M11S1, RNG105, p137GPI " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012686 4076 CAPRIN1 http://www.ncbi.nlm.nih.gov/gene/?term=4076 "GPIAP1, GPIP137, GRIP137, M11S1, RNG105, p137GPI " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012687 4077 NBR1 http://www.ncbi.nlm.nih.gov/gene/?term=4077 "1A1-3B, IAI3B, M17S2, MIG19 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012688 4077 NBR1 http://www.ncbi.nlm.nih.gov/gene/?term=4077 "1A1-3B, IAI3B, M17S2, MIG19 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012689 407800 Ecm2 http://www.ncbi.nlm.nih.gov/gene/?term=407800 "9030618O22Rik, BC065151, tenonectin " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012690 407813 BC059841 http://www.ncbi.nlm.nih.gov/gene/?term=407813 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012691 407823 Baz2b http://www.ncbi.nlm.nih.gov/gene/?term=407823 "5830435C13Rik, BC053917, D2Ertd794e " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012692 407823 Baz2b http://www.ncbi.nlm.nih.gov/gene/?term=407823 "5830435C13Rik, BC053917, D2Ertd794e " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00012693 40785 CG42724 http://www.ncbi.nlm.nih.gov/gene/?term=40785 "Dmel_ CG15187, CG31367, CG33097, Dmel\CG42724, Dmel_CG31367, Dmel_CG33097 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012694 40785 CG42724 http://www.ncbi.nlm.nih.gov/gene/?term=40785 "Dmel_ CG15187, CG31367, CG33097, Dmel\CG42724, Dmel_CG31367, Dmel_CG33097 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012695 407975 MIR17HG http://www.ncbi.nlm.nih.gov/gene/?term=407975 "C13orf25, FGLDS2, LINC00048, MIHG1, MIRH1, MIRHG1, NCRNA00048, miR-17-92 " lncRNA Homo sapiens 16266980 Nucleus Lung cancer cell Northern blot|RT-PCR "In addition, we were able to show predominant localization of C13orf25 transcripts within the nucleus and introduction of the expression construct of the miR-17-92 cluster, but not the putative open reading frame of C13orf25, enhancing lung cancer cell growth. " RLID00012696 407975 MIR17HG http://www.ncbi.nlm.nih.gov/gene/?term=407975 "C13orf25, FGLDS2, LINC00048, MIHG1, MIRH1, MIRHG1, NCRNA00048, miR-17-92 " lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012697 407975 MIR17HG http://www.ncbi.nlm.nih.gov/gene/?term=407975 "C13orf25, FGLDS2, LINC00048, MIHG1, MIRH1, MIRHG1, NCRNA00048, miR-17-92 " lncRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00012698 407 ARR3 http://www.ncbi.nlm.nih.gov/gene/?term=407 ARRX mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012699 408050 NOMO3 http://www.ncbi.nlm.nih.gov/gene/?term=408050 Nomo mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012700 408050 NOMO3 http://www.ncbi.nlm.nih.gov/gene/?term=408050 Nomo mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012701 408068 Zfp738 http://www.ncbi.nlm.nih.gov/gene/?term=408068 "3830402I07Rik, 6720487G11Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012702 40814 CG1307 http://www.ncbi.nlm.nih.gov/gene/?term=40814 "Dmel_ BG:DS00004.12, Dmel\CG1307 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012703 40815 twr http://www.ncbi.nlm.nih.gov/gene/?term=40815 "Dmel_CG2358, AF160889, BG:DS00004.11, BcDNA:GM04682, CG2358, Dmel\CG2358, EfW5, Ov15, Spase18-21, Spase18/21, l(3)05614, l(3)84Aa " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012704 40815 twr http://www.ncbi.nlm.nih.gov/gene/?term=40815 "Dmel_CG2358, AF160889, BG:DS00004.11, BcDNA:GM04682, CG2358, Dmel\CG2358, EfW5, Ov15, Spase18-21, Spase18/21, l(3)05614, l(3)84Aa " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012705 4082 MARCKS http://www.ncbi.nlm.nih.gov/gene/?term=4082 "80K-L, MACS, PKCSL, PRKCSL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012706 40830 bcd http://www.ncbi.nlm.nih.gov/gene/?term=40830 "Dmel_CG1034, BCD, BG:DS00276.7, Bcd, CG1034, Dmel\CG1034, bic, mum, prd4 " mRNA Drosophila melanogaster 16319114 Posterior Oocyte In situ hybridization "During stages 7-9, bcd mRNA is transported to the oocyte, where it localizes as a ring in the anterior cortex. As it enters the oocyte, bcd mRNA encounters MTs necessary for its maintenance organized at the anterior cortex. In grk mutant oocytes, bcd localizes to the anterior as well as to the posterior pole. The anterior localization of bcd suggests the presence of MT minus-ends there. " RLID00012707 40830 bcd http://www.ncbi.nlm.nih.gov/gene/?term=40830 "Dmel_CG1034, BCD, BG:DS00276.7, Bcd, CG1034, Dmel\CG1034, bic, mum, prd4 " mRNA Drosophila melanogaster 16319114 Anterior Oocyte In situ hybridization "During stages 7-9, bcd mRNA is transported to the oocyte, where it localizes as a ring in the anterior cortex. " RLID00012708 40830 bcd http://www.ncbi.nlm.nih.gov/gene/?term=40830 "Dmel_CG1034, BCD, BG:DS00276.7, Bcd, CG1034, Dmel\CG1034, bic, mum, prd4 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012709 40831 Ama http://www.ncbi.nlm.nih.gov/gene/?term=40831 "Dmel_CG2198, AMA, BG:DS00276.6, CG2198, CT7244, Dmel\CG2198, M109, ama " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00012710 40834 ftz http://www.ncbi.nlm.nih.gov/gene/?term=40834 "Dmel_CG2047, BG:DS07876.1, CG2047, Dm-Ftz, Dm-ftz, DmFtz, Dmel\CG2047, Dmftz, FTZ, Ftz, Ual, l(3)84Ag " mRNA Drosophila melanogaster 15280214 Basal Embryo In situ hybridization "Whereas embryos laid by wild-type mothers have an almost exclusively apical distribution of pair-rule mRNAs such as eve, ftz, h and runt (run), those laid by egl3e/eglWU50 mothers accumulate a large proportion of these transcripts in the basal cytoplasm (Fig. 5A). " RLID00012711 4084 MXD1 http://www.ncbi.nlm.nih.gov/gene/?term=4084 "BHLHC58, MAD, MAD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012712 4084 MXD1 http://www.ncbi.nlm.nih.gov/gene/?term=4084 "BHLHC58, MAD, MAD1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012713 40850 Alh http://www.ncbi.nlm.nih.gov/gene/?term=40850 "Dmel_CG1070, AF10, CG1070, Dalf, Dmel\CG1070, anon-WO0118547.226, dAF10, l(3)84Be, l(3)g2, l(3)g5, l(3)j13A6, l(3)j8C8, l(3)j8c8, l(3)r13, l(3j8C8, stk " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012714 40850 Alh http://www.ncbi.nlm.nih.gov/gene/?term=40850 "Dmel_CG1070, AF10, CG1070, Dalf, Dmel\CG1070, anon-WO0118547.226, dAF10, l(3)84Be, l(3)g2, l(3)g5, l(3)j13A6, l(3)j8C8, l(3)j8c8, l(3)r13, l(3j8C8, stk " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012715 4085 MAD2L1 http://www.ncbi.nlm.nih.gov/gene/?term=4085 "HSMAD2, MAD2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012716 4085 MAD2L1 http://www.ncbi.nlm.nih.gov/gene/?term=4085 "HSMAD2, MAD2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012717 4086 SMAD1 http://www.ncbi.nlm.nih.gov/gene/?term=4086 "BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012718 4086 SMAD1 http://www.ncbi.nlm.nih.gov/gene/?term=4086 "BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012719 4087 SMAD2 http://www.ncbi.nlm.nih.gov/gene/?term=4087 "JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012720 4087 SMAD2 http://www.ncbi.nlm.nih.gov/gene/?term=4087 "JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012721 4087 SMAD2 http://www.ncbi.nlm.nih.gov/gene/?term=4087 "JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012722 4087 SMAD2 http://www.ncbi.nlm.nih.gov/gene/?term=4087 "JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012723 4087 SMAD2 http://www.ncbi.nlm.nih.gov/gene/?term=4087 "JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012724 4088 SMAD3 http://www.ncbi.nlm.nih.gov/gene/?term=4088 "HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012725 4089 SMAD4 http://www.ncbi.nlm.nih.gov/gene/?term=4089 "DPC4, JIP, MADH4, MYHRS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012726 4089 SMAD4 http://www.ncbi.nlm.nih.gov/gene/?term=4089 "DPC4, JIP, MADH4, MYHRS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012727 4089 SMAD4 http://www.ncbi.nlm.nih.gov/gene/?term=4089 "DPC4, JIP, MADH4, MYHRS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012728 408 ARRB1 http://www.ncbi.nlm.nih.gov/gene/?term=408 "ARB1, ARR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012729 40909 alpha-Est1 http://www.ncbi.nlm.nih.gov/gene/?term=40909 "Dmel_CG1031, A, Alpha-Est1, CG1031, DmalphaE1, Dmel\CG1031, Est1, Q9VIC3_DROME, aE1, alpha est1, alphaE1 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012730 4090 SMAD5 http://www.ncbi.nlm.nih.gov/gene/?term=4090 "DWFC, JV5-1, MADH5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012731 4090 SMAD5 http://www.ncbi.nlm.nih.gov/gene/?term=4090 "DWFC, JV5-1, MADH5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012732 4090 SMAD5 http://www.ncbi.nlm.nih.gov/gene/?term=4090 "DWFC, JV5-1, MADH5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012733 4091 SMAD6 http://www.ncbi.nlm.nih.gov/gene/?term=4091 "AOVD2, HsT17432, MADH6, MADH7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012734 4092 SMAD7 http://www.ncbi.nlm.nih.gov/gene/?term=4092 "CRCS3, MADH7, MADH8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012735 4092 SMAD7 http://www.ncbi.nlm.nih.gov/gene/?term=4092 "CRCS3, MADH7, MADH8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012736 40932 mRpS9 http://www.ncbi.nlm.nih.gov/gene/?term=40932 "Dmel_CG2957, CG2957, Dmel\CG2957, MRP-S9 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012737 40938 CG10445 http://www.ncbi.nlm.nih.gov/gene/?term=40938 Dmel_ Dmel\CG10445 mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00012738 4093 SMAD9 http://www.ncbi.nlm.nih.gov/gene/?term=4093 "MADH6, MADH9, PPH2, SMAD8, SMAD8/9, SMAD8A, SMAD8B " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00012739 40943 CG2781 http://www.ncbi.nlm.nih.gov/gene/?term=40943 Dmel_ Dmel\CG2781 mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012740 40948 CG10435 http://www.ncbi.nlm.nih.gov/gene/?term=40948 Dmel_ Dmel\CG10435 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012741 40959 CG7878 http://www.ncbi.nlm.nih.gov/gene/?term=40959 "Dmel_ DmRH26, Dmel\CG7878, cg7878 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012742 40972 RpA-70 http://www.ncbi.nlm.nih.gov/gene/?term=40972 "Dmel_CG9633, CG9633, D-RPA70, D-SSB, DRP-A, DmRPA, Dmel\CG9633, RP-A, RPA, RPA 70, RPA 70 kDa, RPA1, RPA70, RpA1, RpA70, Rpa-70, Ssb-70, dRP-A, dmrpa1, i164 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012743 40973 Mcm2 http://www.ncbi.nlm.nih.gov/gene/?term=40973 "Dmel_CG7538, CG7538, DmMCM2, DmMcm2, DmeMCM2, Dmel\CG7538, MCM2, MCM2-7, MCM2_DROME, McM2, PCR3, dMCM2, dMcm2, l(3)rL074 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012744 4097 MAFG http://www.ncbi.nlm.nih.gov/gene/?term=4097 hMAF mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012745 40980 mRpL1 http://www.ncbi.nlm.nih.gov/gene/?term=40980 "Dmel_CG7494, CG7494, Dmel\CG7494, L1 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012746 40980 mRpL1 http://www.ncbi.nlm.nih.gov/gene/?term=40980 "Dmel_CG7494, CG7494, Dmel\CG7494, L1 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012747 4099 MAG http://www.ncbi.nlm.nih.gov/gene/?term=4099 "GMA, S-MAG, SIGLEC-4A, SIGLEC4A, SPG75 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012748 409 ARRB2 http://www.ncbi.nlm.nih.gov/gene/?term=409 "ARB2, ARR2, BARR2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012749 41009 CG11737 http://www.ncbi.nlm.nih.gov/gene/?term=41009 Dmel_ Dmel\CG11737 mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012750 4102 MAGEA3 http://www.ncbi.nlm.nih.gov/gene/?term=4102 "CT1.3, HIP8, HYPD, MAGE3, MAGEA6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012751 4105 MAGEA6 http://www.ncbi.nlm.nih.gov/gene/?term=4105 "CT1.6, MAGE-3b, MAGE3B, MAGE6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012752 41062 pyd http://www.ncbi.nlm.nih.gov/gene/?term=41062 "Dmel_CG43140, CG11782, CG11962, CG12409, CG31349, CG43140, CG9729, CG9731, CG9763, CT36877, DZO-1, Dmel\CG43140, Dmel_CG31349, Dmel_CG9731, Pch, Pyd, Pyd/ZO-1, Tamou, ZO-1, ZO1, dzo-1(Z01), tam, xvt, pyd " mRNA Drosophila melanogaster 17923096 Cell junction Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00012753 41062 pyd http://www.ncbi.nlm.nih.gov/gene/?term=41062 "Dmel_CG43140, CG11782, CG11962, CG12409, CG31349, CG43140, CG9729, CG9731, CG9763, CT36877, DZO-1, Dmel\CG43140, Dmel_CG31349, Dmel_CG9731, Pch, Pyd, Pyd/ZO-1, Tamou, ZO-1, ZO1, dzo-1(Z01), tam, xvt, pyd " mRNA Drosophila melanogaster 17923096 Cytoskeleton Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00012754 41062 pyd http://www.ncbi.nlm.nih.gov/gene/?term=41062 "Dmel_CG43140, CG11782, CG11962, CG12409, CG31349, CG43140, CG9729, CG9731, CG9763, CT36877, DZO-1, Dmel\CG43140, Dmel_CG31349, Dmel_CG9731, Pch, Pyd, Pyd/ZO-1, Tamou, ZO-1, ZO1, dzo-1(Z01), tam, xvt, pyd " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012755 41062 pyd http://www.ncbi.nlm.nih.gov/gene/?term=41062 "Dmel_CG43140, CG11782, CG11962, CG12409, CG31349, CG43140, CG9729, CG9731, CG9763, CT36877, DZO-1, Dmel\CG43140, Dmel_CG31349, Dmel_CG9731, Pch, Pyd, Pyd/ZO-1, Tamou, ZO-1, ZO1, dzo-1(Z01), tam, xvt, pyd " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012756 41066 osk http://www.ncbi.nlm.nih.gov/gene/?term=41066 "Dmel_CG10901, CG10901, Dm-osk, Dmel\CG10901, OSK, Osk, Oskar, norka " mRNA Drosophila melanogaster 7566149 Posterior Oocyte In situ hybridization "The localization of oskar (osk) RNA to the posterior pole of the developing fruit fly (Drosophila) oocyte induces the assembly of pole plasm, causing development of the abdomen and germ line. " RLID00012757 41066 osk http://www.ncbi.nlm.nih.gov/gene/?term=41066 "Dmel_CG10901, CG10901, Dm-osk, Dmel\CG10901, OSK, Osk, Oskar, norka " mRNA Drosophila melanogaster 11131516 Posterior Embryo In situ hybridization "For its assembly, localization of gurken mRNA and its translation at the posterior pole of early oogenic stages is essential for establishing the posterior pole of the oocyte. Subsequently, oskar mRNA becomes localized to the posterior pole where its translation leads to the assembly of a functional germ plasm " RLID00012758 41066 osk http://www.ncbi.nlm.nih.gov/gene/?term=41066 "Dmel_CG10901, CG10901, Dm-osk, Dmel\CG10901, OSK, Osk, Oskar, norka " mRNA Drosophila melanogaster 15130488 Posterior Oocyte In situ hybridization "The Staufen-dependent localization of oskar mRNA to the posterior of the Drosophila oocyte induces the formation of the pole plasm, which contains the abdominal and germline determinants " RLID00012759 41066 osk http://www.ncbi.nlm.nih.gov/gene/?term=41066 "Dmel_CG10901, CG10901, Dm-osk, Dmel\CG10901, OSK, Osk, Oskar, norka " mRNA Drosophila melanogaster 15939385 Posterior Oocyte In situ hybridization We found anterior localized osk mRNA in 100% of the eggs from osk-bcd30 UTR heterozygous mothers while the osk transcript was also present at the posterior pole where it normally occurs. RLID00012760 41066 osk http://www.ncbi.nlm.nih.gov/gene/?term=41066 "Dmel_CG10901, CG10901, Dm-osk, Dmel\CG10901, OSK, Osk, Oskar, norka " mRNA Drosophila melanogaster 16319114 Posterior Oocyte In situ hybridization "Oskar (osk) mRNA is transported to the posterior pole and gurken (grk) mRNA is localized to an antero-dorsal cap near the oocyte nucleus (reviewed by Riechmann and Ephrussi, 2001). The localization of these axes determining transcripts occurs in several steps and is dependent on MTs, cytoplasmic Dynein and Kinesin I. " RLID00012761 41066 osk http://www.ncbi.nlm.nih.gov/gene/?term=41066 "Dmel_CG10901, CG10901, Dm-osk, Dmel\CG10901, OSK, Osk, Oskar, norka " mRNA Drosophila melanogaster 26242323 Germ plasm Embryo Fluorescence in situ hybridization "Next we determined the distribution of the known germ plasm enriched mRNAs cycB, nos, pgc, gcl and oskar (osk) and one control mRNAccr4, which appears evenly distributed throughout the embryo4 (Fig. 2a,b,h). " RLID00012762 41066 osk http://www.ncbi.nlm.nih.gov/gene/?term=41066 "Dmel_CG10901, CG10901, Dm-osk, Dmel\CG10901, OSK, Osk, Oskar, norka " mRNA Drosophila melanogaster 12134163 Posterior Oocyte In situ hybridization "Microtubules and the plus-end-directed microtubule motor Kinesin I are required for the selective accumulation of oskar mRNA at the posterior cortex of the Drosophila melanogaster oocyte, which is essential to posterior patterning and pole plasm assembly. " RLID00012763 41079 Prosbeta3 http://www.ncbi.nlm.nih.gov/gene/?term=41079 "Dmel_CG11981, 11981, Beta-3, CG11981, Dmel\CG11981, Pros beta3, beta-3, beta3 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012764 41087 Rel http://www.ncbi.nlm.nih.gov/gene/?term=41087 "Dmel_CG11992, CG11992, Dmel\CG11992, NF-kappaB, NFkappaB, REL, RELI-p110, Rel/NF-kappaB, RelA, ird, ird4, l(3)neo36, rel, relish, Rel " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00012765 410 ARSA http://www.ncbi.nlm.nih.gov/gene/?term=410 MLD mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012766 41114 CG45050 http://www.ncbi.nlm.nih.gov/gene/?term=41114 "Dmel_ BcDNA:RE70963, CG16750, CG16751, CG33187, CG33188, CG3393, CG33936, CG33937, CG43674, Dmel\CG45050, Dmel_CG33937, Dmel_CG43674, anon-85Da, anon-EST:fe1B11, anon-EST:fe2G11, drn " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012767 4111 MAGEA12 http://www.ncbi.nlm.nih.gov/gene/?term=4111 "CT1.12, MAGE12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012768 41126 alpha-Man-IIa http://www.ncbi.nlm.nih.gov/gene/?term=41126 "Dmel_CG18802, CG18474, CG18802, CG8139, DM-GII.1, Dmel\CG18802, GMII, GmII, MAN-2, Man, Man-II, alpha-Man-II, dGMII, dGMIIb " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012769 41158 Kap-alpha3 http://www.ncbi.nlm.nih.gov/gene/?term=41158 "Dmel_CG9423, 0335/13, CG9423, Dalpha3, Dmel\CG9423, IMPalpha3, Imp alpha-3, Imp-alpha3, KAP-ALPHA3, Kap alpha3, Kap-?3, Kapalpha3, Kpna3, alphaKap3, dKap-alpha3, dimpalpha3, imp alpha3, imp-a3, imp-alpha3, impalpha3, kpn-alpha3, l(3)S033513 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012770 41158 Kap-alpha3 http://www.ncbi.nlm.nih.gov/gene/?term=41158 "Dmel_CG9423, 0335/13, CG9423, Dalpha3, Dmel\CG9423, IMPalpha3, Imp alpha-3, Imp-alpha3, KAP-ALPHA3, Kap alpha3, Kap-?3, Kapalpha3, Kpna3, alphaKap3, dKap-alpha3, dimpalpha3, imp alpha3, imp-a3, imp-alpha3, impalpha3, kpn-alpha3, l(3)S033513 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012771 4115 MAGEB4 http://www.ncbi.nlm.nih.gov/gene/?term=4115 CT3.6 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012772 4115 MAGEB4 http://www.ncbi.nlm.nih.gov/gene/?term=4115 CT3.6 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012773 4116 MAGOH http://www.ncbi.nlm.nih.gov/gene/?term=4116 "MAGOH1A, MAGOH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012774 41171 CG9492 http://www.ncbi.nlm.nih.gov/gene/?term=41171 Dmel_ Dmel\CG9492 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012775 41178 Unc-115b http://www.ncbi.nlm.nih.gov/gene/?term=41178 "Dmel_CG31332, CG31332, CG9489, Dmel\CG31332, anon-WO0140519.9, unc-115 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012776 41178 Unc-115b http://www.ncbi.nlm.nih.gov/gene/?term=41178 "Dmel_CG31332, CG31332, CG9489, Dmel\CG31332, anon-WO0140519.9, unc-115 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012777 4117 MAK http://www.ncbi.nlm.nih.gov/gene/?term=4117 RP62 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012778 4117 MAK http://www.ncbi.nlm.nih.gov/gene/?term=4117 RP62 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012779 41180 dmt http://www.ncbi.nlm.nih.gov/gene/?term=41180 "Dmel_CG8374, 0481/03, CG8374, Dmel\CG8374, Dmt, anon-WO0118547.317, aul, s048103 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012780 41181 hyd http://www.ncbi.nlm.nih.gov/gene/?term=41181 "Dmel_CG9484, CG9484, Dmel\CG9484, HYD, Hyd, NP_524296.2, UBE 3A, c43, l(3)85Ea, l(3)C43, l(3)C43-3, l(3)SG33, l(3)c43, l[[3]]c43 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012781 411 ARSB http://www.ncbi.nlm.nih.gov/gene/?term=411 "ASB, G4S, MPS6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012782 411 ARSB http://www.ncbi.nlm.nih.gov/gene/?term=411 "ASB, G4S, MPS6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012783 41205 CG8507 http://www.ncbi.nlm.nih.gov/gene/?term=41205 Dmel_ Dmel\CG8507 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012784 41205 CG8507 http://www.ncbi.nlm.nih.gov/gene/?term=41205 Dmel_ Dmel\CG8507 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012785 41217 Glut4EF http://www.ncbi.nlm.nih.gov/gene/?term=41217 "Dmel_CG34360, BcDNA:GH25505, BcDNA:GM06804, BcDNA:RE66512, BcDNA:RH63124, CG11676, CG12802, CG12804, CG12805, CG32469, CG33975, CG34360, CG43757, D- Dmel\CG34360, Dmel_CG12802, Dmel_CG33975, stretch " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012786 41219 Art4 http://www.ncbi.nlm.nih.gov/gene/?term=41219 "Dmel_CG5358, CARM1, CG5358, DART4, Dmel\CG5358, dArt 4 " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012787 4121 MAN1A1 http://www.ncbi.nlm.nih.gov/gene/?term=4121 "HUMM3, HUMM9, MAN9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012788 4121 MAN1A1 http://www.ncbi.nlm.nih.gov/gene/?term=4121 "HUMM3, HUMM9, MAN9 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012789 4122 MAN2A2 http://www.ncbi.nlm.nih.gov/gene/?term=4122 MANA2X mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012790 4122 MAN2A2 http://www.ncbi.nlm.nih.gov/gene/?term=4122 MANA2X mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012791 4123 MAN2C1 http://www.ncbi.nlm.nih.gov/gene/?term=4123 "MAN6A8, MANA, MANA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012792 4124 MAN2A1 http://www.ncbi.nlm.nih.gov/gene/?term=4124 "AMan II, GOLIM7, MANA2, MANII " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012793 4124 MAN2A1 http://www.ncbi.nlm.nih.gov/gene/?term=4124 "AMan II, GOLIM7, MANA2, MANII " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012794 4124 MAN2A1 http://www.ncbi.nlm.nih.gov/gene/?term=4124 "AMan II, GOLIM7, MANA2, MANII " mRNA Homo sapiens 22679391 Endoplasmic reticulum U2OS cell RT-PCR "Figure 3B: The levels of several transcripts in the ER fraction were analyzed as in (A). Measured transcripts include those encoding ER luminal proteins (BiP, Calreticulin), ER membrane proteins (Inositol-3-phosphate Receptor (IP3 Receptor), Sec61α, Trapα, and Fatty Acid Desaturase 3 (FADS3)), a Golgi protein (Mannosidase 2A (Man2A)), plasma membrane proteins (Integrin β1, and Transferrin Receptor (Tf Receptor)), and a secreted protein (Interleukin 7 (IL7)). All measurements were standardized to the level of mRNA in the ER fraction from control cells. Data are collected from Figure 3B. " RLID00012795 41260 Bruce http://www.ncbi.nlm.nih.gov/gene/?term=41260 "Dmel_CG6303, BRUCE, CG6303, Dmel\CG6303, bruce, dBRUCE, dBruce, dbruce, mod86 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012796 41260 Bruce http://www.ncbi.nlm.nih.gov/gene/?term=41260 "Dmel_CG6303, BRUCE, CG6303, Dmel\CG6303, bruce, dBRUCE, dBruce, dbruce, mod86 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012797 41265 jumu http://www.ncbi.nlm.nih.gov/gene/?term=41265 "Dmel_CG4029, 5295, CG4029, Dmel\CG4029, Dmjumu, Dom, Dwhn, E(var)631, Jumeau, Jumu, Scim31, Whn, jumeaux/Dom, l(3)06142, l(3)06439, jumu " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012798 41265 jumu http://www.ncbi.nlm.nih.gov/gene/?term=41265 "Dmel_CG4029, 5295, CG4029, Dmel\CG4029, Dmjumu, Dom, Dwhn, E(var)631, Jumeau, Jumu, Scim31, Whn, jumeaux/Dom, l(3)06142, l(3)06439, jumu " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012799 41299 CG14693 http://www.ncbi.nlm.nih.gov/gene/?term=41299 Dmel_ Dmel\CG14693 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012800 41299 CG14693 http://www.ncbi.nlm.nih.gov/gene/?term=41299 Dmel_ Dmel\CG14693 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012801 4129 MAOB http://www.ncbi.nlm.nih.gov/gene/?term=4129 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012802 412 STS http://www.ncbi.nlm.nih.gov/gene/?term=412 "ARSC, ARSC1, ASC, ES, SSDD, XLI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012803 41311 Fdh http://www.ncbi.nlm.nih.gov/gene/?term=41311 "Dmel_CG6598, ADHX, ADHX_DROME, CG6598, Dmel\CG6598, GSNOR, ODH, Odh, fdh, gfd, gfd/odh, odh " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012804 4131 MAP1B http://www.ncbi.nlm.nih.gov/gene/?term=4131 "FUTSCH, MAP5, PPP1R102 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012805 41324 CG6629 http://www.ncbi.nlm.nih.gov/gene/?term=41324 Dmel_ Dmel\CG6629 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012806 4133 MAP2 http://www.ncbi.nlm.nih.gov/gene/?term=4133 "MAP2AB, MAP2C, MAP2 " mRNA Homo sapiens 1824108 Dendrite Neuron - "In the case of MAP2, the mRNA that encodes the protein is also located in dendrites. " RLID00012807 41347 RpL3 http://www.ncbi.nlm.nih.gov/gene/?term=41347 "Dmel_CG4863, CG4863, Dmel\CG4863, L3, Rpl3, anon-EST:GressD4, chr3R:7047878..7048035, rpL3 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012808 4134 MAP4 http://www.ncbi.nlm.nih.gov/gene/?term=4134 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012809 4134 MAP4 http://www.ncbi.nlm.nih.gov/gene/?term=4134 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012810 4134 MAP4 http://www.ncbi.nlm.nih.gov/gene/?term=4134 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012811 4134 MAP4 http://www.ncbi.nlm.nih.gov/gene/?term=4134 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012812 41363 pros http://www.ncbi.nlm.nih.gov/gene/?term=41363 "Dmel_CG17228, 0244/09, 0320/10, 0441/16, 0451/09, 0563/18, 0585/13, 0664/07, 0671/02, 0763/13, 0989/01, 1135/07, 1135/09, 1167/13, 1316/02, 671/2, BcDNA:HL08040, CG17228, DMPROSPER, DROPROSA, Dmel\CG17228, PROS, PROS-1, PROS-2, Pro, Pros, Prosp, Voila, anon-WO0140519.15, l(3)10419, l(3)j12C8, l(3)j6E2, l(3)rH013, l(3)rI160, l(3)rJ806, l(3)rK137, l(3)rK204, l(3)rL433, l(3)rO534, pro, voila " mRNA Drosophila melanogaster 9637686 Apical Embryo In situ hybridization "Miranda is required to localize prospero mRNA. prospero mRNA localizes on the apical side of neuroblasts at interphase (arrow in a) and moves to the basal cortex during mitosis (arrowhead in b). In the absence of Miranda, the RNA is evenly distributed in all neuroblasts (c,d,e). " RLID00012813 41363 pros http://www.ncbi.nlm.nih.gov/gene/?term=41363 "Dmel_CG17228, 0244/09, 0320/10, 0441/16, 0451/09, 0563/18, 0585/13, 0664/07, 0671/02, 0763/13, 0989/01, 1135/07, 1135/09, 1167/13, 1316/02, 671/2, BcDNA:HL08040, CG17228, DMPROSPER, DROPROSA, Dmel\CG17228, PROS, PROS-1, PROS-2, Pro, Pros, Prosp, Voila, anon-WO0140519.15, l(3)10419, l(3)j12C8, l(3)j6E2, l(3)rH013, l(3)rI160, l(3)rJ806, l(3)rK137, l(3)rK204, l(3)rL433, l(3)rO534, pro, voila " mRNA Drosophila melanogaster 9637686 Basal Embryo In situ hybridization "Miranda is required to localize prospero mRNA.prospero mRNA localizes on the apical side of neuroblasts at interphase (arrow in a) and moves to the basal cortex during mitosis (arrowhead in b). In the absence of Miranda, the RNA is evenly distributed in all neuroblasts (c,d,e). " RLID00012814 41363 pros http://www.ncbi.nlm.nih.gov/gene/?term=41363 "Dmel_CG17228, 0244/09, 0320/10, 0441/16, 0451/09, 0563/18, 0585/13, 0664/07, 0671/02, 0763/13, 0989/01, 1135/07, 1135/09, 1167/13, 1316/02, 671/2, BcDNA:HL08040, CG17228, DMPROSPER, DROPROSA, Dmel\CG17228, PROS, PROS-1, PROS-2, Pro, Pros, Prosp, Voila, anon-WO0140519.15, l(3)10419, l(3)j12C8, l(3)j6E2, l(3)rH013, l(3)rI160, l(3)rJ806, l(3)rK137, l(3)rK204, l(3)rL433, l(3)rO534, pro, voila " mRNA Drosophila melanogaster 15852043 Basal Neuroblasts - The localization of prospero mRNA to the basal cortex of D. melanogaster neuroblasts is also actin and myosin dependent. RLID00012815 41391 CG6791 http://www.ncbi.nlm.nih.gov/gene/?term=41391 Dmel_ Dmel\CG6791 mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012816 41397 CG14712 http://www.ncbi.nlm.nih.gov/gene/?term=41397 Dmel_ Dmel\CG14712 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012817 41397 CG14712 http://www.ncbi.nlm.nih.gov/gene/?term=41397 Dmel_ Dmel\CG14712 mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012818 414070 BC026600 http://www.ncbi.nlm.nih.gov/gene/?term=414070 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012819 414093 A830082N09Rik http://www.ncbi.nlm.nih.gov/gene/?term=414093 Gm17567 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012820 4140 MARK3 http://www.ncbi.nlm.nih.gov/gene/?term=4140 "CTAK1, KP78, PAR1A, Par-1a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012821 4140 MARK3 http://www.ncbi.nlm.nih.gov/gene/?term=4140 "CTAK1, KP78, PAR1A, Par-1a " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012822 4140 MARK3 http://www.ncbi.nlm.nih.gov/gene/?term=4140 "CTAK1, KP78, PAR1A, Par-1a " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012823 4140 MARK3 http://www.ncbi.nlm.nih.gov/gene/?term=4140 "CTAK1, KP78, PAR1A, Par-1a " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012824 414101 E130317F20Rik http://www.ncbi.nlm.nih.gov/gene/?term=414101 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012825 414109 9830163H01Rik http://www.ncbi.nlm.nih.gov/gene/?term=414109 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012826 414115 D330050I16Rik http://www.ncbi.nlm.nih.gov/gene/?term=414115 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012827 414123 Mir670hg http://www.ncbi.nlm.nih.gov/gene/?term=414123 E530001K10Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012828 4141 MARS http://www.ncbi.nlm.nih.gov/gene/?term=4141 "CMT2U, ILFS2, ILLD, METRS, MRS, MTRNS, SPG70 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012829 4141 MARS http://www.ncbi.nlm.nih.gov/gene/?term=4141 "CMT2U, ILFS2, ILLD, METRS, MRS, MTRNS, SPG70 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012830 4141 MARS http://www.ncbi.nlm.nih.gov/gene/?term=4141 "CMT2U, ILFS2, ILLD, METRS, MRS, MTRNS, SPG70 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012831 4141 MARS http://www.ncbi.nlm.nih.gov/gene/?term=4141 "CMT2U, ILFS2, ILLD, METRS, MRS, MTRNS, SPG70 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012832 41428 ClC-a http://www.ncbi.nlm.nih.gov/gene/?term=41428 "Dmel_CG31116, CG14726, CG31116, CG6942, CLC-2, Clc-a, DmClC-2, DmClC-a, DmClCa, Dmel\CG31116, FBgn0037951 " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012833 414318 C9orf106 http://www.ncbi.nlm.nih.gov/gene/?term=414318 bA65J3.5 mRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00012834 414328 IDNK http://www.ncbi.nlm.nih.gov/gene/?term=414328 "C9orf103, bA522I20.2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012835 414328 IDNK http://www.ncbi.nlm.nih.gov/gene/?term=414328 "C9orf103, bA522I20.2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012836 4144 MAT2A http://www.ncbi.nlm.nih.gov/gene/?term=4144 "MATA2, MATII, SAMS2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012837 4144 MAT2A http://www.ncbi.nlm.nih.gov/gene/?term=4144 "MATA2, MATII, SAMS2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012838 414519 ldlrap1-b http://www.ncbi.nlm.nih.gov/gene/?term=414519 "arh, arh1, arh2, fhcb1, fhcb2, ldlrap1, xptb " mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00012839 414538 trim36 http://www.ncbi.nlm.nih.gov/gene/?term=414538 Haprin mRNA Xenopus laevis 19675128 Germ plasm Embryo In situ hybridization|qRT-PCR We find that trim36 is expressed in the germ plasm and encodes a ubiquitin ligase of the Tripartite motif-containing (Trim) family. RLID00012840 414538 trim36 http://www.ncbi.nlm.nih.gov/gene/?term=414538 Haprin mRNA Xenopus laevis 19675128 Vegetal Embryo In situ hybridization|qRT-PCR Analysis of trim36 mRNA expression during early development further confirmed its vegetal cortex localization and also showed that trim36 is enriched in the germ plasm of oocytes and early embryos. RLID00012841 414538 trim36 http://www.ncbi.nlm.nih.gov/gene/?term=414538 Haprin mRNA Xenopus laevis 23615278 Vegetal Oocyte|Embryo Whole mount in situ hybridization "Thus, Dnd1 anchors trim36 RNA to the vegetal cortex and is required for accumulation of Trim36 protein in the vegetal cortex. " RLID00012842 414538 trim36 http://www.ncbi.nlm.nih.gov/gene/?term=414538 Haprin mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00012843 41455 mfas http://www.ncbi.nlm.nih.gov/gene/?term=41455 "Dmel_CG3359, 87A7-9/7, BEST:GH06752, CG3359, Dmel\CG3359, Mfas, anon-87Af, anon-EST:Liang-97, anon-WO0140519.174, clone 97, gh06752 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012844 41455 mfas http://www.ncbi.nlm.nih.gov/gene/?term=41455 "Dmel_CG3359, 87A7-9/7, BEST:GH06752, CG3359, Dmel\CG3359, Mfas, anon-87Af, anon-EST:Liang-97, anon-WO0140519.174, clone 97, gh06752 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012845 41457 Ect3 http://www.ncbi.nlm.nih.gov/gene/?term=41457 "Dmel_CG3132, 87A7-9/8, CG3132, Dmel\CG3132, anon-87Ag " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012846 414641 sesn2 http://www.ncbi.nlm.nih.gov/gene/?term=414641 mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00012847 414660 MGC81075 http://www.ncbi.nlm.nih.gov/gene/?term=414660 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00012848 414660 MGC81075 http://www.ncbi.nlm.nih.gov/gene/?term=414660 mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00012849 4147 MATN2 http://www.ncbi.nlm.nih.gov/gene/?term=4147 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012850 414801 Itprip http://www.ncbi.nlm.nih.gov/gene/?term=414801 "4833424O12Rik, DANGER, mKIAA1754 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012851 41483 Su(var)3-9 http://www.ncbi.nlm.nih.gov/gene/?term=41483 "Dmel_CG43664, CG43664, CG6476, Dmel\CG43664, Dmel_CG6476, E(var)3-2, SU(VAR)3-9, SUV39, SUV39H1, Su(VAR)3-9, Su(Var)3-9, Su(var), Su(var) 3-902, Su(var)306, Su(var)310, Su(var)328, Su-var(3)9, Su-var(3)902, SuVar3-9, Suv 3-9, Suvar(3)9, Suvar3-9, Suvar39, caa56376 Suvar39 Dm, dSU(VAR)3-9, dSu(var)3-9, ptn, su(var)3-9, Su(var)3-9 " mRNA Drosophila melanogaster 17923096 Posterior Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00012852 414872 Zyg11b http://www.ncbi.nlm.nih.gov/gene/?term=414872 "1110046I03Rik, 2810482G21Rik, D4Mgi23, Gm431, mKIAA1730 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012853 414899 BLID http://www.ncbi.nlm.nih.gov/gene/?term=414899 BRCC2 mRNA Homo sapiens 25753659 Ribosome HT1080 cell qRT-PCR Figure S1: Polysomal gradient analysis. HT1080 cells were incubated under control (21% oxygen) or hypoxic (1% oxygen) conditions for up to 36 h as described in Figure 1. Shown are representative original RT-PCR data (30 cycles for beta-Actin and the external standard [extSt]; 35 cycles for the other genes) from pooled samples to visualize mRNA distribution following fractionation of sucrose gradients at control conditions (C) and 36 h of hypoxia (Hy). The external standard (a synthetic in vitro transcript) was diluted to appropriate concentration for qPCR and added directly after gradient fractionation and prior to RNA isolation as a technical control. The external standard served for fraction dependent normalization. RLID00012854 414919 C8orf82 http://www.ncbi.nlm.nih.gov/gene/?term=414919 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012855 4149 MAX http://www.ncbi.nlm.nih.gov/gene/?term=4149 bHLHd4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012856 414 ARSD http://www.ncbi.nlm.nih.gov/gene/?term=414 ASD mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012857 4150 MAZ http://www.ncbi.nlm.nih.gov/gene/?term=4150 "PUR1, Pur-1, SAF-1, SAF-2, SAF-3, ZF87, ZNF801, Zif87 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012858 4150 MAZ http://www.ncbi.nlm.nih.gov/gene/?term=4150 "PUR1, Pur-1, SAF-1, SAF-2, SAF-3, ZF87, ZNF801, Zif87 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012859 415115 Neurl2 http://www.ncbi.nlm.nih.gov/gene/?term=415115 "Neur2, Ozz, Ozz-E3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00012860 415116 PIM3 http://www.ncbi.nlm.nih.gov/gene/?term=415116 pim-3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012861 41511 CG10035 http://www.ncbi.nlm.nih.gov/gene/?term=41511 "Dmel_ Dmel\CG10035, anon-EST:Liang-20, clone 20 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012862 415128 CYP2E1 http://www.ncbi.nlm.nih.gov/gene/?term=415128 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00012863 4151 MB http://www.ncbi.nlm.nih.gov/gene/?term=4151 "PVALB, myoglobgin " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012864 41521 CG5167 http://www.ncbi.nlm.nih.gov/gene/?term=41521 Dmel_ Dmel\CG5167 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012865 41521 CG5167 http://www.ncbi.nlm.nih.gov/gene/?term=41521 Dmel_ Dmel\CG5167 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012866 41526 CG17202 http://www.ncbi.nlm.nih.gov/gene/?term=41526 "Dmel_ BcDNA:RH21090, Dmel\CG17202 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012867 4152 MBD1 http://www.ncbi.nlm.nih.gov/gene/?term=4152 "CXXC3, PCM1, RFT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012868 4152 MBD1 http://www.ncbi.nlm.nih.gov/gene/?term=4152 "CXXC3, PCM1, RFT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012869 4154 MBNL1 http://www.ncbi.nlm.nih.gov/gene/?term=4154 "EXP, MBNL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012870 41550 Vha55 http://www.ncbi.nlm.nih.gov/gene/?term=41550 "Dmel_CG17369, 1208/13, ATP6V1B1, CG17369, Dmel\CG17369, SzA, V-ATPase, VAT-2, l(3)87Ca, l(3)SzA, l(3)j2E9, vha55 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012871 4155 MBP http://www.ncbi.nlm.nih.gov/gene/?term=4155 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012872 4155 MBP http://www.ncbi.nlm.nih.gov/gene/?term=4155 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012873 41576 CG31345 http://www.ncbi.nlm.nih.gov/gene/?term=41576 "Dmel_ CG10135, CG14388, Dmel\CG31345 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012874 41576 CG31345 http://www.ncbi.nlm.nih.gov/gene/?term=41576 "Dmel_ CG10135, CG14388, Dmel\CG31345 " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012875 4157 MC1R http://www.ncbi.nlm.nih.gov/gene/?term=4157 "CMM5, MSH-R, SHEP2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012876 416051 ARPC4 http://www.ncbi.nlm.nih.gov/gene/?term=416051 mRNA Gallus gallus 15923655 Cell leading edge Fibroblast Fluorescence in situ hybridization "The localization of the Arp2/3 complex mRNAs is dependent on both actin filaments and microtubules, because disruption of either cytoskeletal system (with cytochalasin D and colchicine, respectively) inhibited the localization of all seven subunit mRNAs. To address these questions, double detection of two types of mRNAs simultaneously in the same cells was performed by sequential FISH-TSA. As shown in Fig. 5A-C, Arp3 mRNA appears not to be precisely colocalized with β-actin mRNA, although they both concentrate together in the protrusions. In addition, the Arp2 and Arp3 mRNAs also do not colocalize, although they are both concentrated together in the protrusions (Fig. 5D-F). " RLID00012877 416051 ARPC4 http://www.ncbi.nlm.nih.gov/gene/?term=416051 mRNA Gallus gallus 15923655 Cell leading edge Fibroblast Fluorescence in situ hybridization "Figure 7: Quantification of Arp2/3-complex mRNA localization in fibroblasts. The proportion of the cells with localized mRNA was quantified by counting all the cells in randomly selected fields in the fluorescence microscope. 300-500 cells were scored for each mRNA from three independent experiments. Error bars indicate s.e.m. **, statistically significant (P<0.01) differences from control basal level of poly-A RNA. " RLID00012878 41615 timeout http://www.ncbi.nlm.nih.gov/gene/?term=41615 "Dmel_CG7855, CG14381, CG14382, CG7855, CG8148, Dmel\CG7855, TIM2, dtim2, tim2 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012879 41627 Su(var)3-7 http://www.ncbi.nlm.nih.gov/gene/?term=41627 "Dmel_CG8599, CG8599, DmSu(var)3-7, Dmel\CG8599, SU(VAR)3-7, Su(Var)3-7, Su(var)(3)3, Su(var)(3)7, Su-var(3)7, Suvar(3)7, l(3)87El " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012880 41646 Droj2 http://www.ncbi.nlm.nih.gov/gene/?term=41646 "Dmel_CG8863, CG8863, DROJ2, Dmel\CG8863, anon-WO0118547.404 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012881 41646 Droj2 http://www.ncbi.nlm.nih.gov/gene/?term=41646 "Dmel_CG8863, CG8863, DROJ2, Dmel\CG8863, anon-WO0118547.404 " mRNA Drosophila melanogaster 25838129 Perinuclear Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012882 416490 ARPC1B http://www.ncbi.nlm.nih.gov/gene/?term=416490 mRNA Gallus gallus 15923655 Cell leading edge Fibroblast Fluorescence in situ hybridization "Figure 7: Quantification of Arp2/3-complex mRNA localization in fibroblasts. The proportion of the cells with localized mRNA was quantified by counting all the cells in randomly selected fields in the fluorescence microscope. 300-500 cells were scored for each mRNA from three independent experiments. Error bars indicate s.e.m. **, statistically significant (P<0.01) differences from control basal level of poly-A RNA. " RLID00012883 41650 GILT1 http://www.ncbi.nlm.nih.gov/gene/?term=41650 "Dmel_CG9796, CG9796, Dmel\CG9796, GILT " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012884 41665 CG10841 http://www.ncbi.nlm.nih.gov/gene/?term=41665 "Dmel_ Dmel\CG10841, anon-WO0140519.42 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012885 4166 CHST6 http://www.ncbi.nlm.nih.gov/gene/?term=4166 MCDC1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012886 4166 CHST6 http://www.ncbi.nlm.nih.gov/gene/?term=4166 MCDC1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012887 41670 B52 http://www.ncbi.nlm.nih.gov/gene/?term=41670 "Dmel_CG10851/SRp55, B52/dSRp55, CG10851, Dmel\CG10851, E(Dfd), E726, MabB52, RRM8, RSp55, Rbp8, SR55, SRp55, dSRp55, l(3)s2249, rrm8 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012888 41670 B52 http://www.ncbi.nlm.nih.gov/gene/?term=41670 "Dmel_CG10851/SRp55, B52/dSRp55, CG10851, Dmel\CG10851, E(Dfd), E726, MabB52, RRM8, RSp55, Rbp8, SR55, SRp55, dSRp55, l(3)s2249, rrm8 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012889 41673 Lkb1 http://www.ncbi.nlm.nih.gov/gene/?term=41673 "Dmel_CG9374, CG9374, DmLKB1, Dmel\CG9374, LKB1, LKB1/PEUTZ JEGHERS KINASE, PAR-4, PAR4, STK11, anon-EST:Posey135, dLKB1, dlkb1, lkb1, par-4 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012890 416837 ARPC3 http://www.ncbi.nlm.nih.gov/gene/?term=416837 mRNA Gallus gallus 15923655 Cell leading edge Fibroblast Fluorescence in situ hybridization "The localization of the Arp2/3 complex mRNAs is dependent on both actin filaments and microtubules, because disruption of either cytoskeletal system (with cytochalasin D and colchicine, respectively) inhibited the localization of all seven subunit mRNAs. To address these questions, double detection of two types of mRNAs simultaneously in the same cells was performed by sequential FISH-TSA. As shown in Fig. 5A-C, Arp3 mRNA appears not to be precisely colocalized with β-actin mRNA, although they both concentrate together in the protrusions. In addition, the Arp2 and Arp3 mRNAs also do not colocalize, although they are both concentrated together in the protrusions (Fig. 5D-F). " RLID00012891 41686 CG9312 http://www.ncbi.nlm.nih.gov/gene/?term=41686 "Dmel_ CT26517, Dmel\CG9312 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012892 4168 MCF2 http://www.ncbi.nlm.nih.gov/gene/?term=4168 "ARHGEF21, DBL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012893 41702 CG9925 http://www.ncbi.nlm.nih.gov/gene/?term=41702 Dmel_ Dmel\CG9925 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012894 4170 MCL1 http://www.ncbi.nlm.nih.gov/gene/?term=4170 "BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012895 4170 MCL1 http://www.ncbi.nlm.nih.gov/gene/?term=4170 "BCL2L3, EAT-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, MCL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012896 4170 MCL1 http://www.ncbi.nlm.nih.gov/gene/?term=4170 "BCL2L3, EAT-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, MCL1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012897 4170 MCL1 http://www.ncbi.nlm.nih.gov/gene/?term=4170 "BCL2L3, EAT-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, MCL1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012898 41718 Abi http://www.ncbi.nlm.nih.gov/gene/?term=41718 "Dmel_CG9749-1, Ablphilin, CG9749, Dmel\CG9749, abi, dAbi, Abi " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012899 4171 MCM2 http://www.ncbi.nlm.nih.gov/gene/?term=4171 "BM28, CCNL1, CDCL1, D3S3194, MITOTIN, cdc19 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012900 4171 MCM2 http://www.ncbi.nlm.nih.gov/gene/?term=4171 "BM28, CCNL1, CDCL1, D3S3194, MITOTIN, cdc19 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012901 4172 MCM3 http://www.ncbi.nlm.nih.gov/gene/?term=4172 "HCC5, P1-MCM3, P1.h, RLFB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012902 4172 MCM3 http://www.ncbi.nlm.nih.gov/gene/?term=4172 "HCC5, P1-MCM3, P1.h, RLFB " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012903 4172 MCM3 http://www.ncbi.nlm.nih.gov/gene/?term=4172 "HCC5, P1-MCM3, P1.h, RLFB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012904 4173 MCM4 http://www.ncbi.nlm.nih.gov/gene/?term=4173 "CDC21, CDC54, NKCD, NKGCD, P1-CDC21, hCdc21 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012905 4173 MCM4 http://www.ncbi.nlm.nih.gov/gene/?term=4173 "CDC21, CDC54, NKCD, NKGCD, P1-CDC21, hCdc21 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012906 4174 MCM5 http://www.ncbi.nlm.nih.gov/gene/?term=4174 "CDC46, P1-CDC46 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012907 4174 MCM5 http://www.ncbi.nlm.nih.gov/gene/?term=4174 "CDC46, P1-CDC46 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012908 41758 CG8461 http://www.ncbi.nlm.nih.gov/gene/?term=41758 Dmel_ Dmel\CG8461 mRNA Drosophila melanogaster 25838129 Basal Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012909 4175 MCM6 http://www.ncbi.nlm.nih.gov/gene/?term=4175 "MCG40308, Mis5, P105MCM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012910 4175 MCM6 http://www.ncbi.nlm.nih.gov/gene/?term=4175 "MCG40308, Mis5, P105MCM " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012911 4176 MCM7 http://www.ncbi.nlm.nih.gov/gene/?term=4176 "CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012912 41780 BigH1 http://www.ncbi.nlm.nih.gov/gene/?term=41780 "Dmel_CG3509, CG3509, Dmel\CG3509, dBigH1 " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012913 4179 CD46 http://www.ncbi.nlm.nih.gov/gene/?term=4179 "AHUS2, MCP, MIC10, TLX, TRA2.10 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012914 4179 CD46 http://www.ncbi.nlm.nih.gov/gene/?term=4179 "AHUS2, MCP, MIC10, TLX, TRA2.10 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012915 4179 CD46 http://www.ncbi.nlm.nih.gov/gene/?term=4179 "AHUS2, MCP, MIC10, TLX, TRA2.10 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012916 41823 GlyS http://www.ncbi.nlm.nih.gov/gene/?term=41823 "Dmel_CG6904, CG6904, CG6940, Dmel\CG6904, GS, anon-WO0118547.108, dGS " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012917 41838 mRpS10 http://www.ncbi.nlm.nih.gov/gene/?term=41838 "Dmel_CG4247, BcDNA:GM25447, CG4247, Dmel\CG4247, MRP-S10, MrpS10 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012918 41838 mRpS10 http://www.ncbi.nlm.nih.gov/gene/?term=41838 "Dmel_CG4247, BcDNA:GM25447, CG4247, Dmel\CG4247, MRP-S10, MrpS10 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012919 41852 Tm1 http://www.ncbi.nlm.nih.gov/gene/?term=41852 "Dmel_CG4898, 1305/10, 2299, BcDNA:GH09289, BcDNA:LD37158, BcDNA:SD21996, CG4898, Dm Tm1, Dm TmH33, Dm TmH34, DmTm1, Dmel\CG4898, PmI, TM, TM1, TMII, Tm, TmH, TmH-33, TmH-34, TmH33, TmH34, TmII, Tmr33, Tmr34, TnH, TnH-33, TnH-34, cTM, cTm, cTmII, chr3R:11122272..11122408, l(3)02299, l(3)S130510, l(3)s2958, mTmII, region 3, tm1, tmII, tropomyosin " mRNA Drosophila melanogaster 17923096 Posterior Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00012920 41852 Tm1 http://www.ncbi.nlm.nih.gov/gene/?term=41852 "Dmel_CG4898, 1305/10, 2299, BcDNA:GH09289, BcDNA:LD37158, BcDNA:SD21996, CG4898, Dm Tm1, Dm TmH33, Dm TmH34, DmTm1, Dmel\CG4898, PmI, TM, TM1, TMII, Tm, TmH, TmH-33, TmH-34, TmH33, TmH34, TmII, Tmr33, Tmr34, TnH, TnH-33, TnH-34, cTM, cTm, cTmII, chr3R:11122272..11122408, l(3)02299, l(3)S130510, l(3)s2958, mTmII, region 3, tm1, tmII, tropomyosin " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012921 41852 Tm1 http://www.ncbi.nlm.nih.gov/gene/?term=41852 "Dmel_CG4898, 1305/10, 2299, BcDNA:GH09289, BcDNA:LD37158, BcDNA:SD21996, CG4898, Dm Tm1, Dm TmH33, Dm TmH34, DmTm1, Dmel\CG4898, PmI, TM, TM1, TMII, Tm, TmH, TmH-33, TmH-34, TmH33, TmH34, TmII, Tmr33, Tmr34, TnH, TnH-33, TnH-34, cTM, cTm, cTmII, chr3R:11122272..11122408, l(3)02299, l(3)S130510, l(3)s2958, mTmII, region 3, tm1, tmII, tropomyosin " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012922 41852 Tm1 http://www.ncbi.nlm.nih.gov/gene/?term=41852 "Dmel_CG4898, 1305/10, 2299, BcDNA:GH09289, BcDNA:LD37158, BcDNA:SD21996, CG4898, Dm Tm1, Dm TmH33, Dm TmH34, DmTm1, Dmel\CG4898, PmI, TM, TM1, TMII, Tm, TmH, TmH-33, TmH-34, TmH33, TmH34, TmII, Tmr33, Tmr34, TnH, TnH-33, TnH-34, cTM, cTm, cTmII, chr3R:11122272..11122408, l(3)02299, l(3)S130510, l(3)s2958, mTmII, region 3, tm1, tmII, tropomyosin " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012923 41852 Tm1 http://www.ncbi.nlm.nih.gov/gene/?term=41852 "Dmel_CG4898, 1305/10, 2299, BcDNA:GH09289, BcDNA:LD37158, BcDNA:SD21996, CG4898, Dm Tm1, Dm TmH33, Dm TmH34, DmTm1, Dmel\CG4898, PmI, TM, TM1, TMII, Tm, TmH, TmH-33, TmH-34, TmH33, TmH34, TmII, Tmr33, Tmr34, TnH, TnH-33, TnH-34, cTM, cTm, cTmII, chr3R:11122272..11122408, l(3)02299, l(3)S130510, l(3)s2958, mTmII, region 3, tm1, tmII, tropomyosin " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012924 4188 MDFI http://www.ncbi.nlm.nih.gov/gene/?term=4188 "I-MF, I-mfa " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012925 4188 MDFI http://www.ncbi.nlm.nih.gov/gene/?term=4188 "I-MF, I-mfa " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012926 41899 pxb http://www.ncbi.nlm.nih.gov/gene/?term=41899 "Dmel_CG33207, BcDNA:RE16319, CG14873, CG14874, CG33207, CG33207/Pxb, Dmel\CG33207, Pxb " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012927 4189 DNAJB9 http://www.ncbi.nlm.nih.gov/gene/?term=4189 "ERdj4, MDG-1, MDG1, MST049, MSTP049 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012928 4190 MDH1 http://www.ncbi.nlm.nih.gov/gene/?term=4190 "HEL-S-32, MDH-s, MDHA, MGC:1375, MOR2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012929 4190 MDH1 http://www.ncbi.nlm.nih.gov/gene/?term=4190 "HEL-S-32, MDH-s, MDHA, MGC:1375, MOR2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012930 4190 MDH1 http://www.ncbi.nlm.nih.gov/gene/?term=4190 "HEL-S-32, MDH-s, MDHA, MGC:1375, MOR2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012931 4191 MDH2 http://www.ncbi.nlm.nih.gov/gene/?term=4191 "M-MDH, MDH, MGC:3559, MOR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012932 4191 MDH2 http://www.ncbi.nlm.nih.gov/gene/?term=4191 "M-MDH, MDH, MGC:3559, MOR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012933 4192 MDK http://www.ncbi.nlm.nih.gov/gene/?term=4192 "ARAP, MK, NEGF2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012934 4192 MDK http://www.ncbi.nlm.nih.gov/gene/?term=4192 "ARAP, MK, NEGF2 " mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00012935 4192 MDK http://www.ncbi.nlm.nih.gov/gene/?term=4192 "ARAP, MK, NEGF2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012936 4193 MDM2 http://www.ncbi.nlm.nih.gov/gene/?term=4193 "ACTFS, HDMX, hdm2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012937 4193 MDM2 http://www.ncbi.nlm.nih.gov/gene/?term=4193 "ACTFS, HDMX, hdm2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012938 4193 MDM2 http://www.ncbi.nlm.nih.gov/gene/?term=4193 "ACTFS, HDMX, hdm2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012939 4193 MDM2 http://www.ncbi.nlm.nih.gov/gene/?term=4193 "ACTFS, HDMX, hdm2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012940 4194 MDM4 http://www.ncbi.nlm.nih.gov/gene/?term=4194 "HDMX, MDMX, MRP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012941 4194 MDM4 http://www.ncbi.nlm.nih.gov/gene/?term=4194 "HDMX, MDMX, MRP1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012942 4194 MDM4 http://www.ncbi.nlm.nih.gov/gene/?term=4194 "HDMX, MDMX, MRP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012943 4194 MDM4 http://www.ncbi.nlm.nih.gov/gene/?term=4194 "HDMX, MDMX, MRP1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012944 41967 CG6126 http://www.ncbi.nlm.nih.gov/gene/?term=41967 "Dmel_ CT19169, Dmel\CG6126 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012945 41967 CG6126 http://www.ncbi.nlm.nih.gov/gene/?term=41967 "Dmel_ CT19169, Dmel\CG6126 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012946 4199 ME1 http://www.ncbi.nlm.nih.gov/gene/?term=4199 "HUMNDME, MES " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012947 4200 ME2 http://www.ncbi.nlm.nih.gov/gene/?term=4200 ODS1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012948 42015 Scp2 http://www.ncbi.nlm.nih.gov/gene/?term=42015 "Dmel_CG14904, CE, CG14904, Cex, Dcabp-A.2, Dmel\CG14904, JHDK, SCP2, cex, dSCP2 " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012949 4201 MEA1 http://www.ncbi.nlm.nih.gov/gene/?term=4201 "HYS, MEA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012950 4204 MECP2 http://www.ncbi.nlm.nih.gov/gene/?term=4204 "AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012951 4204 MECP2 http://www.ncbi.nlm.nih.gov/gene/?term=4204 "AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT " mRNA Homo sapiens 26251528 Cytoplasm U87 cell Immunofluorescence|Fluorescence in situ hybridization "Providing a parsimonious explanation for these results, biochemical fractionation and in vivo localization studies revealed that MECP2 mRNA colocalized with cytoplasmic FUS(C) in insoluble aggregates, which are characteristic of ALS mutant proteins. " RLID00012952 420519 VIM http://www.ncbi.nlm.nih.gov/gene/?term=420519 mRNA Gallus gallus 2738094 Lamellipodium Skeletal Myoblast|Fibroblast Immunocytochemistry|In situ hybridization "Conversely only 35 % of tubulin or vimentin messages were found in lamellipodia. Two cells, analyzed for hybridization to tubulin and vimentin mRNAs showed a perinuclear localization (66% of the messages), consistent with previous work cited above. " RLID00012953 420519 VIM http://www.ncbi.nlm.nih.gov/gene/?term=420519 mRNA Gallus gallus 3698103 Nucleus Embryo blasts|Fibroblast In situ hybridization "Actin mRNA concentrations were highest at cell extremities, generally in lamellipodia, where grain densities were up to 16-fold higher than in areas near the nucleus. Vimentin mRNA, unlike actin mRNA, was distributed near the nucleus. Tubulin mRNA appeared most concentrated in the peripheral cytoplasm. These results demonstrate that cytoplasmic mRNAs are localized in specific, nonrandom cellular patterns and that localized concentrations of specific proteins may result from corresponding localization of their respective mRNAs. Hence, actin mRNA distribution may result in increased concentration of actin filaments in lamellipodia of motile cells. " RLID00012954 4205 MEF2A http://www.ncbi.nlm.nih.gov/gene/?term=4205 "ADCAD1, RSRFC4, RSRFC9, mef2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012955 42087 Brf http://www.ncbi.nlm.nih.gov/gene/?term=42087 "Dmel_CG31256, BRF, BRF11, CG31256, CG4155, CG5419, Dmel\CG31256, TFIIIB, brf " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012956 42087 Brf http://www.ncbi.nlm.nih.gov/gene/?term=42087 "Dmel_CG31256, BRF, BRF11, CG31256, CG4155, CG5419, Dmel\CG31256, TFIIIB, brf " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012957 4208 MEF2C http://www.ncbi.nlm.nih.gov/gene/?term=4208 "C5DELq14.3, DEL5q14.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012958 4209 MEF2D http://www.ncbi.nlm.nih.gov/gene/?term=4209 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012959 4210 MEFV http://www.ncbi.nlm.nih.gov/gene/?term=4210 "FMF, MEF, TRIM20 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012960 4210 MEFV http://www.ncbi.nlm.nih.gov/gene/?term=4210 "FMF, MEF, TRIM20 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012961 42129 CG31249 http://www.ncbi.nlm.nih.gov/gene/?term=42129 "Dmel_ CG7477, Dmel\CG31249, Q9VEG8 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012962 4212 MEIS2 http://www.ncbi.nlm.nih.gov/gene/?term=4212 "HsT18361, MRG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012963 4214 MAP3K1 http://www.ncbi.nlm.nih.gov/gene/?term=4214 "MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012964 4214 MAP3K1 http://www.ncbi.nlm.nih.gov/gene/?term=4214 "MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012965 4215 MAP3K3 http://www.ncbi.nlm.nih.gov/gene/?term=4215 "MAPKKK3, MEKK3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012966 42160 htl http://www.ncbi.nlm.nih.gov/gene/?term=42160 "Dmel_CG7223, CG7223, CT22273, CT39172, DFGF-R1, DFGF-R2, DFR-1, DFR1, DFR1/DFGF-R2, DPR3, DTRK(FR1), Dfr-1, Dfr1, DmHD-38, Dmel\CG7223, Dtk1, EMS2, FGF-R2, FGFR, FGFR2, FR1, Fr1, HD-38, HTL/FGFR1, Htl, Tk1, dtk1, i100, i150, i79, j372 " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00012967 42169 PP2A-B' http://www.ncbi.nlm.nih.gov/gene/?term=42169 "Dmel_CG7913, B', B'/PR61, B56-1, BcDNA:GM05554, CG 7913, CG7901, CG7913, Dmel\CG7913, PP2A, PP2A B', PP2A-B, PP2A[B'-1], Wrd, anon-WO0118547.420, dB56-1, dPP2A, dPP2A-B56-1, i234, pp2A-B', wrd " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012968 4216 MAP3K4 http://www.ncbi.nlm.nih.gov/gene/?term=4216 "MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012969 4216 MAP3K4 http://www.ncbi.nlm.nih.gov/gene/?term=4216 "MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012970 4217 MAP3K5 http://www.ncbi.nlm.nih.gov/gene/?term=4217 "ASK1, MAPKKK5, MEKK5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012971 42187 CG7156 http://www.ncbi.nlm.nih.gov/gene/?term=42187 Dmel_ Dmel\CG7156 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012972 42187 CG7156 http://www.ncbi.nlm.nih.gov/gene/?term=42187 Dmel_ Dmel\CG7156 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012973 4218 RAB8A http://www.ncbi.nlm.nih.gov/gene/?term=4218 "MEL, RAB8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012974 42196 CG8064 http://www.ncbi.nlm.nih.gov/gene/?term=42196 Dmel_ Dmel\CG8064 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012975 4221 MEN1 http://www.ncbi.nlm.nih.gov/gene/?term=4221 "MEAI, SCG2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012976 4221 MEN1 http://www.ncbi.nlm.nih.gov/gene/?term=4221 "MEAI, SCG2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012977 4222 MEOX1 http://www.ncbi.nlm.nih.gov/gene/?term=4222 "KFS2, MOX1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012978 42233 CG14305 http://www.ncbi.nlm.nih.gov/gene/?term=42233 Dmel_ Dmel\CG14305 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012979 42239 CstF-64 http://www.ncbi.nlm.nih.gov/gene/?term=42239 "Dmel_CG7697, CG7697, CStF 64, CstF 64, CstF64, Dmel\CG7697, dCstF64 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012980 4223 MEOX2 http://www.ncbi.nlm.nih.gov/gene/?term=4223 "GAX, MOX2 " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00012981 42242 CG7702 http://www.ncbi.nlm.nih.gov/gene/?term=42242 "Dmel_ 7702, CT23351, Dmel\CG7702 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012982 42256 CG14299 http://www.ncbi.nlm.nih.gov/gene/?term=42256 Dmel_ Dmel\CG14299 mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012983 42297 nos http://www.ncbi.nlm.nih.gov/gene/?term=42297 "Dmel_CG5637, CG5637, DRONANOS, Dmel\CG5637, Dronanos, NANOS, NOS, Nos, l(3)07117, l(3)j3B6, l(3)j4B6, nNOS " mRNA Drosophila melanogaster 8895662 Posterior Oocyte In situ hybridization "Nos mRNA is localized to the posterior pole of the maturing oocyte during the final stages of oogenesis, af- ter the polarity of the egg chamber has broken down. " RLID00012984 42297 nos http://www.ncbi.nlm.nih.gov/gene/?term=42297 "Dmel_CG5637, CG5637, DRONANOS, Dmel\CG5637, Dronanos, NANOS, NOS, Nos, l(3)07117, l(3)j3B6, l(3)j4B6, nNOS " mRNA Drosophila melanogaster 10415352 Posterior Embryo In situ hybridization "First, the localization of nanos RNA was examined in embryos treated for 30 min with 10mg/ml of CD. Compared to control embryos (Fig. 2A), this treatment has somewhat a somewhat subtle but discernible effect on the localization of nanos RNA (Fig. 2B). In a substantial number of embryos, the RNA was still located at the posterior pole but was more diffuse and in many embryos extended further from the posterior pole. " RLID00012985 42297 nos http://www.ncbi.nlm.nih.gov/gene/?term=42297 "Dmel_CG5637, CG5637, DRONANOS, Dmel\CG5637, Dronanos, NANOS, NOS, Nos, l(3)07117, l(3)j3B6, l(3)j4B6, nNOS " mRNA Drosophila melanogaster 15495201 Germ plasm Oocyte|Embryo In situ hybridization "OSKAR (OSK) and VASA (VAS) proteins, and nanos (nos) RNA, all initially localize to the pole plasm of tud-null oocytes and embryos from tud-null mothers, while localization of germ cell-less (gcl) and polar granule component (pgc), is undetectable or severely reduced. " RLID00012986 42297 nos http://www.ncbi.nlm.nih.gov/gene/?term=42297 "Dmel_CG5637, CG5637, DRONANOS, Dmel\CG5637, Dronanos, NANOS, NOS, Nos, l(3)07117, l(3)j3B6, l(3)j4B6, nNOS " mRNA Drosophila melanogaster 15852043 Germ plasm Oocyte - "MRNAs can also become localized by passively diffusing through the cytoplasm until they are trapped by a localized anchor. Several transcripts, such as nanos, gcl (germ cell-less) and Cyclin B mRNAs, become enriched in the D. melanogaster pole plasm in this way " RLID00012987 42297 nos http://www.ncbi.nlm.nih.gov/gene/?term=42297 "Dmel_CG5637, CG5637, DRONANOS, Dmel\CG5637, Dronanos, NANOS, NOS, Nos, l(3)07117, l(3)j3B6, l(3)j4B6, nNOS " mRNA Drosophila melanogaster 18036786 Germ plasm Embryo In situ hybridization "In contrast, localization of nos to the germ plasm, but not translational regulation, is essential for nos function in the developing germ cells. " RLID00012988 42297 nos http://www.ncbi.nlm.nih.gov/gene/?term=42297 "Dmel_CG5637, CG5637, DRONANOS, Dmel\CG5637, Dronanos, NANOS, NOS, Nos, l(3)07117, l(3)j3B6, l(3)j4B6, nNOS " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00012989 42297 nos http://www.ncbi.nlm.nih.gov/gene/?term=42297 "Dmel_CG5637, CG5637, DRONANOS, Dmel\CG5637, Dronanos, NANOS, NOS, Nos, l(3)07117, l(3)j3B6, l(3)j4B6, nNOS " mRNA Drosophila melanogaster 25848747 Cytoplasm Oocyte Live imaging Live imaging of nos mRNA showed that its localization occurs as a consequence of diffusion within the oocyte cytoplasm and entrapment at the posterior in Vas-containing RNPs known as polar granules RLID00012990 42297 nos http://www.ncbi.nlm.nih.gov/gene/?term=42297 "Dmel_CG5637, CG5637, DRONANOS, Dmel\CG5637, Dronanos, NANOS, NOS, Nos, l(3)07117, l(3)j3B6, l(3)j4B6, nNOS " mRNA Drosophila melanogaster 26242323 Germ plasm Embryo Fluorescence in situ hybridization "Next we determined the distribution of the known germ plasm enriched mRNAs cycB, nos, pgc, gcl and oskar (osk) and one control mRNAccr4, which appears evenly distributed throughout the embryo4 (Fig. 2a,b,h). " RLID00012991 42305 cry http://www.ncbi.nlm.nih.gov/gene/?term=42305 "Dmel_CG3772, CG3772, CRY, Cry, DCry, Dm-CRY1, DmCRY, DmCRY1, Dmcry, Dmel\CG3772, anon-WO0140519.17, anon-WO0140519.19, anon-WO0140519.20, anon-WO0172774.15b, dCRY, dCry, dcry, cry " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012992 42327 Dys http://www.ncbi.nlm.nih.gov/gene/?term=42327 "Dmel_CG34157, CG17750, CG31175, CG34157, CG7240, CG7243, CG7344, DLP, DLP1, DLP186, DLP2, DLP3, DmDLP, DmDYS, Dmel\CG34157, Dp117, Dp186, Dp205, GI3046716, IDLP, det, dmDLP, dmDp186, dmDys, dys " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012993 42327 Dys http://www.ncbi.nlm.nih.gov/gene/?term=42327 "Dmel_CG34157, CG17750, CG31175, CG34157, CG7240, CG7243, CG7344, DLP, DLP1, DLP186, DLP2, DLP3, DmDLP, DmDYS, Dmel\CG34157, Dp117, Dp186, Dp205, GI3046716, IDLP, det, dmDLP, dmDp186, dmDys, dys " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00012994 4232 MEST http://www.ncbi.nlm.nih.gov/gene/?term=4232 PEG1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012995 4233 MET http://www.ncbi.nlm.nih.gov/gene/?term=4233 "AUTS9, DFNB97, HGFR, RCCP2, c-Met " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00012996 4233 MET http://www.ncbi.nlm.nih.gov/gene/?term=4233 "AUTS9, DFNB97, HGFR, RCCP2, c-Met " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00012997 4233 MET http://www.ncbi.nlm.nih.gov/gene/?term=4233 "AUTS9, DFNB97, HGFR, RCCP2, c-Met " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00012998 4233 MET http://www.ncbi.nlm.nih.gov/gene/?term=4233 "AUTS9, DFNB97, HGFR, RCCP2, c-Met " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00012999 4233 MET http://www.ncbi.nlm.nih.gov/gene/?term=4233 "AUTS9, DFNB97, HGFR, RCCP2, c-Met " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013000 4234 METTL1 http://www.ncbi.nlm.nih.gov/gene/?term=4234 "C12orf1, TRM8, TRMT8, YDL201w " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013001 4236 MFAP1 http://www.ncbi.nlm.nih.gov/gene/?term=4236 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013002 4236 MFAP1 http://www.ncbi.nlm.nih.gov/gene/?term=4236 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013003 42379 mira http://www.ncbi.nlm.nih.gov/gene/?term=42379 "Dmel_CG12249, CG12249, Dmel\CG12249, MIR, MIRA, Mir, Mira, Miranda, mir " mRNA Drosophila melanogaster 9637685 Apical Embryo Binding assay "We show further that Staufen, like Miranda and prospero RNA, localizes to the apical cortex then the basal cortex and that Miranda interacts with Staufen physically. " RLID00013004 42379 mira http://www.ncbi.nlm.nih.gov/gene/?term=42379 "Dmel_CG12249, CG12249, Dmel\CG12249, MIR, MIRA, Mir, Mira, Miranda, mir " mRNA Drosophila melanogaster 9637685 Basal Embryo Binding assay "We show further that Staufen, like Miranda and prospero RNA, localizes to the apical cortex then the basal cortex and that Miranda interacts with Staufen physically. " RLID00013005 42379 mira http://www.ncbi.nlm.nih.gov/gene/?term=42379 "Dmel_CG12249, CG12249, Dmel\CG12249, MIR, MIRA, Mir, Mira, Miranda, mir " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00013006 42379 mira http://www.ncbi.nlm.nih.gov/gene/?term=42379 "Dmel_CG12249, CG12249, Dmel\CG12249, MIR, MIRA, Mir, Mira, Miranda, mir " mRNA Drosophila melanogaster 17923096 Cell junction Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00013007 42379 mira http://www.ncbi.nlm.nih.gov/gene/?term=42379 "Dmel_CG12249, CG12249, Dmel\CG12249, MIR, MIRA, Mir, Mira, Miranda, mir " mRNA Drosophila melanogaster 17923096 Cytoskeleton Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00013008 42385 MED25 http://www.ncbi.nlm.nih.gov/gene/?term=42385 "Dmel_CG12254, Arc92, CG12254, Dmel\CG12254, LD07688, Med25, dARC92, dDrip97, med25 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013009 4238 MFAP3 http://www.ncbi.nlm.nih.gov/gene/?term=4238 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013010 4240 MFGE8 http://www.ncbi.nlm.nih.gov/gene/?term=4240 "BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013011 42433 TFAM http://www.ncbi.nlm.nih.gov/gene/?term=42433 "Dmel_CG4217, CG4217, D-mtTFA, Dmel\CG4217, MTTFA, Tfam, d-TFAM, d-mttfa, d-tfam, mtTFA, mttfa, tfam " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013012 42445 H http://www.ncbi.nlm.nih.gov/gene/?term=42445 "Dmel_CG5460, CG5460, Dmel\CG5460 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00013013 42451 CG4000 http://www.ncbi.nlm.nih.gov/gene/?term=42451 Dmel_ Dmel\CG4000 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013014 42453 Cdk2 http://www.ncbi.nlm.nih.gov/gene/?term=42453 "Dmel_CG10498, CDC2C, CDC2c, CDK2, CDK2/CDC2c, CG10498, Cdc2c, Dcdc2c, DmCdc2, DmCdk2, Dmcdc2c, Dmel\CG10498, S(Sev-CycE)3A, cdc2c, cdk2, dCdk2 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013015 4245 MGAT1 http://www.ncbi.nlm.nih.gov/gene/?term=4245 "GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, MGAT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013016 42460 Syp http://www.ncbi.nlm.nih.gov/gene/?term=42460 "Dmel_CG17838, AI945337, CG17838, Dmel\CG17838, anon-WO0118547.613, cg17838, l(3)03806, syp " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013017 4247 MGAT2 http://www.ncbi.nlm.nih.gov/gene/?term=4247 "CDG2A, CDGS2, GLCNACTII, GNT-II, GNT2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013018 4247 MGAT2 http://www.ncbi.nlm.nih.gov/gene/?term=4247 "CDG2A, CDGS2, GLCNACTII, GNT-II, GNT2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013019 4247 MGAT2 http://www.ncbi.nlm.nih.gov/gene/?term=4247 "CDG2A, CDGS2, GLCNACTII, GNT-II, GNT2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013020 4248 MGAT3 http://www.ncbi.nlm.nih.gov/gene/?term=4248 "GNT-III, GNT3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013021 4249 MGAT5 http://www.ncbi.nlm.nih.gov/gene/?term=4249 "GNT-V, GNT-VA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013022 42502 ppan http://www.ncbi.nlm.nih.gov/gene/?term=42502 "Dmel_CG5786, CG5786, Dmel\CG5786, PPAN, Ppan, l(3)02231, l(3)j6B6 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013023 4253 CTAGE5 http://www.ncbi.nlm.nih.gov/gene/?term=4253 "MEA6, MGEA, MGEA11, MGEA6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013024 4254 KITLG http://www.ncbi.nlm.nih.gov/gene/?term=4254 "DCUA, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013025 4254 KITLG http://www.ncbi.nlm.nih.gov/gene/?term=4254 "DCUA, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013026 4255 MGMT http://www.ncbi.nlm.nih.gov/gene/?term=4255 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013027 42564 tsl http://www.ncbi.nlm.nih.gov/gene/?term=42564 "Dmel_CG6705, CG6705, Dm-tsl, Dmel\CG6705, Tsl, fs(3)00617 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013028 42564 tsl http://www.ncbi.nlm.nih.gov/gene/?term=42564 "Dmel_CG6705, CG6705, Dm-tsl, Dmel\CG6705, Tsl, fs(3)00617 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013029 42567 CASK http://www.ncbi.nlm.nih.gov/gene/?term=42567 "Dmel_CG6703, CAKI, CAMGUK, CG13412, CG13413, CG6703, CMG, CMG/CASK, Caki, CamGUK, CamguK, Camguk, Cask, Cmg, DLin-2, Dmel\CG6703, RE09582p, caki, camguk, cask, cmg, dCASK " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013030 42567 CASK http://www.ncbi.nlm.nih.gov/gene/?term=42567 "Dmel_CG6703, CAKI, CAMGUK, CG13412, CG13413, CG6703, CMG, CMG/CASK, Caki, CamGUK, CamguK, Camguk, Cask, Cmg, DLin-2, Dmel\CG6703, RE09582p, caki, camguk, cask, cmg, dCASK " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013031 4257 MGST1 http://www.ncbi.nlm.nih.gov/gene/?term=4257 "GST12, MGST, MGST-I " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013032 4257 MGST1 http://www.ncbi.nlm.nih.gov/gene/?term=4257 "GST12, MGST, MGST-I " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013033 42581 CG6678 http://www.ncbi.nlm.nih.gov/gene/?term=42581 Dmel_ Dmel\CG6678 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013034 4258 MGST2 http://www.ncbi.nlm.nih.gov/gene/?term=4258 "GST2, MGST-II " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013035 4258 MGST2 http://www.ncbi.nlm.nih.gov/gene/?term=4258 "GST2, MGST-II " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013036 4258 MGST2 http://www.ncbi.nlm.nih.gov/gene/?term=4258 "GST2, MGST-II " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013037 4259 MGST3 http://www.ncbi.nlm.nih.gov/gene/?term=4259 GST-III mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013038 4259 MGST3 http://www.ncbi.nlm.nih.gov/gene/?term=4259 GST-III mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013039 4261 CIITA http://www.ncbi.nlm.nih.gov/gene/?term=4261 "C2TAIV, MHC2TA, NLRA, CIITA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013040 4261 CIITA http://www.ncbi.nlm.nih.gov/gene/?term=4261 "C2TAIV, MHC2TA, NLRA, CIITA " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013041 42634 mats http://www.ncbi.nlm.nih.gov/gene/?term=42634 "Dmel_CG13852, CG13852, DMob1, Dmel\CG13852, Dmob1, Mats, Mob1, anon-WO0118547.303, dmob1 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013042 42659 CG33110 http://www.ncbi.nlm.nih.gov/gene/?term=42659 "Dmel_ CG13844, CG6926, Dmel\CG33110 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013043 4267 CD99 http://www.ncbi.nlm.nih.gov/gene/?term=4267 "HBA71, MIC2, MIC2X, MIC2Y, MSK5X " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013044 4267 CD99 http://www.ncbi.nlm.nih.gov/gene/?term=4267 "HBA71, MIC2, MIC2X, MIC2Y, MSK5X " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013045 4267 CD99 http://www.ncbi.nlm.nih.gov/gene/?term=4267 "HBA71, MIC2, MIC2X, MIC2Y, MSK5X " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013046 42702 Usp12-46 http://www.ncbi.nlm.nih.gov/gene/?term=42702 "Dmel_CG7023, CG7023, Dmel\CG7023, Q9VCT9 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013047 42751 CG13827 http://www.ncbi.nlm.nih.gov/gene/?term=42751 "Dmel_ BcDNA:RE30473, Dmel\CG13827, PEX11C " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013048 42754 CG6763 http://www.ncbi.nlm.nih.gov/gene/?term=42754 Dmel_ Dmel\CG6763 mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013049 42762 CG4408 http://www.ncbi.nlm.nih.gov/gene/?term=42762 "Dmel_ BEST:GH09055, Dmel\CG4408 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013050 42773 CG10175 http://www.ncbi.nlm.nih.gov/gene/?term=42773 Dmel_ Dmel\CG10175 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013051 4277 MICB http://www.ncbi.nlm.nih.gov/gene/?term=4277 PERB11.2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013052 42784 CG31145 http://www.ncbi.nlm.nih.gov/gene/?term=42784 "Dmel_ CG10187, CG13820, CG13821, Dmel\CG31145 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013053 42784 CG31145 http://www.ncbi.nlm.nih.gov/gene/?term=42784 "Dmel_ CG10187, CG13820, CG13821, Dmel\CG31145 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013054 42784 CG31145 http://www.ncbi.nlm.nih.gov/gene/?term=42784 "Dmel_ CG10187, CG13820, CG13821, Dmel\CG31145 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013055 42793 CG10254 http://www.ncbi.nlm.nih.gov/gene/?term=42793 "Dmel_ BcDNA:LD22087, Dmel\CG10254 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013056 42793 CG10254 http://www.ncbi.nlm.nih.gov/gene/?term=42793 "Dmel_ BcDNA:LD22087, Dmel\CG10254 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013057 427 ASAH1 http://www.ncbi.nlm.nih.gov/gene/?term=427 "AC, ACDase, ASAH, PHP, PHP32, SMAPME " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013058 427 ASAH1 http://www.ncbi.nlm.nih.gov/gene/?term=427 "AC, ACDase, ASAH, PHP, PHP32, SMAPME " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013059 4281 MID1 http://www.ncbi.nlm.nih.gov/gene/?term=4281 "BBBG1, FXY, GBBB1, MIDIN, OGS1, OS, OSX, RNF59, TRIM18, XPRF, ZNFXY " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013060 4281 MID1 http://www.ncbi.nlm.nih.gov/gene/?term=4281 "BBBG1, FXY, GBBB1, MIDIN, OGS1, OS, OSX, RNF59, TRIM18, XPRF, ZNFXY " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013061 4282 MIF http://www.ncbi.nlm.nih.gov/gene/?term=4282 "GIF, GLIF, MMIF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013062 4282 MIF http://www.ncbi.nlm.nih.gov/gene/?term=4282 "GIF, GLIF, MMIF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013063 42854 Syx1A http://www.ncbi.nlm.nih.gov/gene/?term=42854 "Dmel_CG31136, CG10716, CG18615, CG31136, CG31136/CG33100, CG5448, CT30033, Dm Syx1, DmSyx1A, Dmel\CG31136, SYX, SYX 1A, SYX1A, Syt1A, Syx, Syx-1A, Syx1, Syx1a, SyxA, anon-EST:Gibbs4, anon-WO02059370.54, dSyx1, dsyn-1A, l(3)06737, synt, syt-1A, syx, syx-1, syx-1A, syx1, syx1A " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013064 42854 Syx1A http://www.ncbi.nlm.nih.gov/gene/?term=42854 "Dmel_CG31136, CG10716, CG18615, CG31136, CG31136/CG33100, CG5448, CT30033, Dm Syx1, DmSyx1A, Dmel\CG31136, SYX, SYX 1A, SYX1A, Syt1A, Syx, Syx-1A, Syx1, Syx1a, SyxA, anon-EST:Gibbs4, anon-WO02059370.54, dSyx1, dsyn-1A, l(3)06737, synt, syt-1A, syx, syx-1, syx-1A, syx1, syx1A " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013065 42859 CG13607 http://www.ncbi.nlm.nih.gov/gene/?term=42859 "Dmel_ 150482_at, Dmel\CG13607 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013066 4285 MIPEP http://www.ncbi.nlm.nih.gov/gene/?term=4285 "HMIP, MIP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013067 4286 MITF http://www.ncbi.nlm.nih.gov/gene/?term=4286 "CMM8, MI, WS2, WS2A, bHLHe32 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013068 42879 CG17786 http://www.ncbi.nlm.nih.gov/gene/?term=42879 Dmel_ Dmel\CG17786 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013069 42879 CG17786 http://www.ncbi.nlm.nih.gov/gene/?term=42879 Dmel_ Dmel\CG17786 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013070 42879 CG17786 http://www.ncbi.nlm.nih.gov/gene/?term=42879 Dmel_ Dmel\CG17786 mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013071 4287 ATXN3 http://www.ncbi.nlm.nih.gov/gene/?term=4287 "AT3, ATX3, JOS, MJD, MJD1, SCA3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013072 4287 ATXN3 http://www.ncbi.nlm.nih.gov/gene/?term=4287 "AT3, ATX3, JOS, MJD, MJD1, SCA3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013073 42880 twin http://www.ncbi.nlm.nih.gov/gene/?term=42880 "Dmel_CG31137, BEST:GH20274, CCR4, CG17741, CG31137, CG5534, CT39331, Ccr4, Dmel\CG31137, Twin, ccr4, twn " mRNA Drosophila melanogaster 26242323 Germ plasm Embryo Fluorescence in situ hybridization "Next we determined the distribution of the known germ plasm enriched mRNAs cycB, nos, pgc, gcl and oskar (osk) and one control mRNAccr4, which appears evenly distributed throughout the embryo4 (Fig. 2a,b,h). " RLID00013074 42880 twin http://www.ncbi.nlm.nih.gov/gene/?term=42880 "Dmel_CG31137, BEST:GH20274, CCR4, CG17741, CG31137, CG5534, CT39331, Ccr4, Dmel\CG31137, Twin, ccr4, twn " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013075 4288 MKI67 http://www.ncbi.nlm.nih.gov/gene/?term=4288 "KIA, MIB-, MIB-1, PPP1R105 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013076 42896 crb http://www.ncbi.nlm.nih.gov/gene/?term=42896 "Dmel_CG6383, 0509/20, 1384/04, CG6383, CRB, CT19912, Crb, Crbs, Crumbs, DmCrb, Dmel\CG6383, crumb, far, l(3)07207, l(3)S050920, l(3)S058104, l(3)j1B5 " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00013077 42899 CG5728 http://www.ncbi.nlm.nih.gov/gene/?term=42899 Dmel_ Dmel\CG5728 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013078 4289 MKLN1 http://www.ncbi.nlm.nih.gov/gene/?term=4289 TWA2 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013079 4289 MKLN1 http://www.ncbi.nlm.nih.gov/gene/?term=4289 TWA2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013080 429041 ARPC2 http://www.ncbi.nlm.nih.gov/gene/?term=429041 mRNA Gallus gallus 15923655 Cell leading edge Fibroblast Fluorescence in situ hybridization "The localization of the Arp2/3 complex mRNAs is dependent on both actin filaments and microtubules, because disruption of either cytoskeletal system (with cytochalasin D and colchicine, respectively) inhibited the localization of all seven subunit mRNAs. To address these questions, double detection of two types of mRNAs simultaneously in the same cells was performed by sequential FISH-TSA. As shown in Fig. 5A-C, Arp3 mRNA appears not to be precisely colocalized with β-actin mRNA, although they both concentrate together in the protrusions. In addition, the Arp2 and Arp3 mRNAs also do not colocalize, although they are both concentrated together in the protrusions (Fig. 5D-F). " RLID00013081 429041 ARPC2 http://www.ncbi.nlm.nih.gov/gene/?term=429041 mRNA Gallus gallus 15923655 Cell leading edge Fibroblast Fluorescence in situ hybridization "Figure 7: Quantification of Arp2/3-complex mRNA localization in fibroblasts. The proportion of the cells with localized mRNA was quantified by counting all the cells in randomly selected fields in the fluorescence microscope. 300-500 cells were scored for each mRNA from three independent experiments. Error bars indicate s.e.m. **, statistically significant (P<0.01) differences from control basal level of poly-A RNA. " RLID00013082 429075 ARPC5 http://www.ncbi.nlm.nih.gov/gene/?term=429075 APOBEC4 mRNA Gallus gallus 15923655 Cell leading edge Fibroblast Fluorescence in situ hybridization "The localization of the Arp2/3 complex mRNAs is dependent on both actin filaments and microtubules, because disruption of either cytoskeletal system (with cytochalasin D and colchicine, respectively) inhibited the localization of all seven subunit mRNAs. To address these questions, double detection of two types of mRNAs simultaneously in the same cells was performed by sequential FISH-TSA. As shown in Fig. 5A-C, Arp3 mRNA appears not to be precisely colocalized with β-actin mRNA, although they both concentrate together in the protrusions. In addition, the Arp2 and Arp3 mRNAs also do not colocalize, although they are both concentrated together in the protrusions (Fig. 5D-F). " RLID00013083 429075 ARPC5 http://www.ncbi.nlm.nih.gov/gene/?term=429075 APOBEC4 mRNA Gallus gallus 15923655 Cell leading edge Fibroblast Fluorescence in situ hybridization "Figure 7: Quantification of Arp2/3-complex mRNA localization in fibroblasts. The proportion of the cells with localized mRNA was quantified by counting all the cells in randomly selected fields in the fluorescence microscope. 300-500 cells were scored for each mRNA from three independent experiments. Error bars indicate s.e.m. **, statistically significant (P<0.01) differences from control basal level of poly-A RNA. " RLID00013084 4291 MLF1 http://www.ncbi.nlm.nih.gov/gene/?term=4291 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013085 4291 MLF1 http://www.ncbi.nlm.nih.gov/gene/?term=4291 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013086 4292 MLH1 http://www.ncbi.nlm.nih.gov/gene/?term=4292 "COCA2, FCC2, HNPCC, HNPCC2, hMLH1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013087 42946 asp http://www.ncbi.nlm.nih.gov/gene/?term=42946 "Dmel_CG6875, ASP, Asp, CG6875, Dm Asp, Dmel\CG6875, anon-96Aa, anon-WO0118547.279 " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00013088 4294 MAP3K10 http://www.ncbi.nlm.nih.gov/gene/?term=4294 "MEKK10, MLK2, MST " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013089 4296 MAP3K11 http://www.ncbi.nlm.nih.gov/gene/?term=4296 "MEKK11, MLK-3, MLK3, PTK1, SPRK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013090 42971 CycB3 http://www.ncbi.nlm.nih.gov/gene/?term=42971 "Dmel_CG5814, CG5814, Cyc B3, Dmel\CG5814, anon-WO0118547.414, cycB3, l(3)L6540 " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013091 4297 KMT2A http://www.ncbi.nlm.nih.gov/gene/?term=4297 "ALL-1, CXXC7, HRX, HTRX1, MLL, MLL-AF9, MLL/GAS7, MLL1, MLL1A, TET1-MLL, TRX1, WDSTS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013092 4297 KMT2A http://www.ncbi.nlm.nih.gov/gene/?term=4297 "ALL-1, CXXC7, HRX, HTRX1, MLL, MLL-AF9, MLL/GAS7, MLL1, MLL1A, TET1-MLL, TRX1, WDSTS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013093 42993 Hr96 http://www.ncbi.nlm.nih.gov/gene/?term=42993 "Dmel_CG11783, CG11783, DHR96, Dhr96, Dmel\CG11783, HR96, NR1J1, dHR96 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013094 429 ASCL1 http://www.ncbi.nlm.nih.gov/gene/?term=429 "ASH1, HASH1, MASH1, bHLHa46 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013095 43005 OstStt3 http://www.ncbi.nlm.nih.gov/gene/?term=43005 "Dmel_CG7748, BcDNA.GM01838, BcDNA:GM01838, CG7748, Dmel\CG7748, STT, anon-WO03054008.7, l(3)j2D9 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013096 4301 MLLT4 http://www.ncbi.nlm.nih.gov/gene/?term=4301 "AF6, MLL-AF6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013097 4301 MLLT4 http://www.ncbi.nlm.nih.gov/gene/?term=4301 "AF6, MLL-AF6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013098 4303 FOXO4 http://www.ncbi.nlm.nih.gov/gene/?term=4303 "AFX, AFX1, MLLT7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013099 43043 CG10425 http://www.ncbi.nlm.nih.gov/gene/?term=43043 Dmel_ Dmel\CG10425 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013100 43067 CHKov1 http://www.ncbi.nlm.nih.gov/gene/?term=43067 "Dmel_CG10618, BcDNA:GH03753, CG10618, Dmel\CG10618, ref(3)D " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013101 43067 CHKov1 http://www.ncbi.nlm.nih.gov/gene/?term=43067 "Dmel_CG10618, BcDNA:GH03753, CG10618, Dmel\CG10618, ref(3)D " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013102 43067 CHKov1 http://www.ncbi.nlm.nih.gov/gene/?term=43067 "Dmel_CG10618, BcDNA:GH03753, CG10618, Dmel\CG10618, ref(3)D " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013103 43067 CHKov1 http://www.ncbi.nlm.nih.gov/gene/?term=43067 "Dmel_CG10618, BcDNA:GH03753, CG10618, Dmel\CG10618, ref(3)D " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013104 43087 msi http://www.ncbi.nlm.nih.gov/gene/?term=43087 "Dmel_CG5099, CG5099, DMSIDNA, Dmel\CG5099, MSI, Msi, SIDNA, anon-EST:Liang-2.35, clone 2.35, dMsi " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013105 43087 msi http://www.ncbi.nlm.nih.gov/gene/?term=43087 "Dmel_CG5099, CG5099, DMSIDNA, Dmel\CG5099, MSI, Msi, SIDNA, anon-EST:Liang-2.35, clone 2.35, dMsi " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013106 4308 TRPM1 http://www.ncbi.nlm.nih.gov/gene/?term=4308 "CSNB1C, LTRPC1, MLSN1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013107 43093 jigr1 http://www.ncbi.nlm.nih.gov/gene/?term=43093 "Dmel_CG17383, CG17383, Dmel\CG17383, JIGR-1, JIGR1, bs29f05.y1 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013108 43096 RASSF8 http://www.ncbi.nlm.nih.gov/gene/?term=43096 "Dmel_CG5053, Boa, CG5053, Dmel\CG5053, d dmRASSF7/8 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013109 430 ASCL2 http://www.ncbi.nlm.nih.gov/gene/?term=430 "ASH2, HASH2, MASH2, bHLHa45 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013110 4311 MME http://www.ncbi.nlm.nih.gov/gene/?term=4311 "CALLA, CD10, NEP, SFE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013111 4313 MMP2 http://www.ncbi.nlm.nih.gov/gene/?term=4313 "CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013112 431676 krt8 http://www.ncbi.nlm.nih.gov/gene/?term=431676 "KERATIN8, XCK1, card2, ck8, cyk8, k2c8, krt2-5 " mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00013113 43186 CG33970 http://www.ncbi.nlm.nih.gov/gene/?term=43186 "Dmel_ CG14559, CG31085, CG6162, CG6166, Dmel\CG33970 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013114 4318 MMP9 http://www.ncbi.nlm.nih.gov/gene/?term=4318 "CLG4B, GELB, MANDP2, MMP-9 " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00013115 43192 CG5447 http://www.ncbi.nlm.nih.gov/gene/?term=43192 Dmel_ Dmel\CG5447 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013116 43192 CG5447 http://www.ncbi.nlm.nih.gov/gene/?term=43192 Dmel_ Dmel\CG5447 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013117 432058 pgam1 http://www.ncbi.nlm.nih.gov/gene/?term=432058 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00013118 4320 MMP11 http://www.ncbi.nlm.nih.gov/gene/?term=4320 "SL-3, ST3, STMY3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013119 432219 cab39 http://www.ncbi.nlm.nih.gov/gene/?term=432219 mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00013120 43222 Tl http://www.ncbi.nlm.nih.gov/gene/?term=43222 "Dmel_CG5490, CG5490, CT17414, Dmel\CG5490, EP(3)1051, EP1051, Fs(1)Tl, Fs(3)Tl, T1, TL, TOL, Toll-1, Toll1, dToll, dToll1, mat(3)9, mel(3)10, mel(3)9, tl, toll, toll-1 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013121 432245 arl8b http://www.ncbi.nlm.nih.gov/gene/?term=432245 arl10c mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00013122 432264 pced1a http://www.ncbi.nlm.nih.gov/gene/?term=432264 fam113a mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00013123 43228 ball http://www.ncbi.nlm.nih.gov/gene/?term=43228 "Dmel_CG6386, BALL, Ball, BcDNA:LD09009, CG6386, Dmel\CG6386, NHK-1, NHK1, VRK, nhk-1, trip " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013124 432369 ATP5EP2 http://www.ncbi.nlm.nih.gov/gene/?term=432369 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013125 432449 A230081H15Rik http://www.ncbi.nlm.nih.gov/gene/?term=432449 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013126 432450 Nkain2 http://www.ncbi.nlm.nih.gov/gene/?term=432450 "6330571D19Rik, AW455467, Tcba1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013127 432467 Hnrnph3 http://www.ncbi.nlm.nih.gov/gene/?term=432467 "AA693301, AI666703, Hnrph3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013128 432486 Gnptab http://www.ncbi.nlm.nih.gov/gene/?term=432486 "EG432486, mKIAA1208 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013129 4324 MMP15 http://www.ncbi.nlm.nih.gov/gene/?term=4324 "MMP-15, MT2-MMP, MT2MMP, MTMMP2, SMCP-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013130 4324 MMP15 http://www.ncbi.nlm.nih.gov/gene/?term=4324 "MMP-15, MT2-MMP, MT2MMP, MTMMP2, SMCP-2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013131 432500 Gm29674 http://www.ncbi.nlm.nih.gov/gene/?term=432500 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013132 432508 Cpsf6 http://www.ncbi.nlm.nih.gov/gene/?term=432508 "4733401N12Rik, AI256641, CFIM, CFIM68, HPBRII-4, HPBRII-7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013133 432518 LOC432518 http://www.ncbi.nlm.nih.gov/gene/?term=432518 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013134 432572 Specc1 http://www.ncbi.nlm.nih.gov/gene/?term=432572 "2810012G08Rik, B230396K10Rik, Cytsb " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013135 4325 MMP16 http://www.ncbi.nlm.nih.gov/gene/?term=4325 "C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013136 432685 LOC432685 http://www.ncbi.nlm.nih.gov/gene/?term=432685 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013137 4326 MMP17 http://www.ncbi.nlm.nih.gov/gene/?term=4326 "MMP-17, MT4-MMP, MT4MMP, MTMMP4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013138 4327027 LOC4327027 http://www.ncbi.nlm.nih.gov/gene/?term=4327027 "OSNPB_010762500, GLUA-1, GLUA1, Gt2, glutelin " mRNA Oryza sativa 24682961 Endoplasmic reticulum Seed Northern blot|RT-PCR "This particle is then exported and moves via the cytoskeleton to the cortical ER. At some point, the complex disassembles and prolamine and glutelin RNAs are targeted to either the PB- or cis-ER, respectively. " RLID00013139 432736 Vmn1r209 http://www.ncbi.nlm.nih.gov/gene/?term=432736 "Gm11315, OTTMUSG00000000514 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013140 4327 MMP19 http://www.ncbi.nlm.nih.gov/gene/?term=4327 "CODA, MMP18, RASI-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013141 432881 Gm5466 http://www.ncbi.nlm.nih.gov/gene/?term=432881 EG432881 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013142 4328881 LOC4328881 http://www.ncbi.nlm.nih.gov/gene/?term=4328881 "OSNPB_020249600, GLUB-2, GLUB2, GluB-7, GluB7 " mRNA Oryza sativa 24682961 Endoplasmic reticulum Seed Northern blot|RT-PCR "This particle is then exported and moves via the cytoskeleton to the cortical ER. At some point, the complex disassembles and prolamine and glutelin RNAs are targeted to either the PB- or cis-ER, respectively. " RLID00013143 4328968 LOC4328968 http://www.ncbi.nlm.nih.gov/gene/?term=4328968 "OSNPB_020268100, GLUB-5, GluB5, glutelin " mRNA Oryza sativa 24682961 Endoplasmic reticulum Seed Northern blot|RT-PCR "This particle is then exported and moves via the cytoskeleton to the cortical ER. At some point, the complex disassembles and prolamine and glutelin RNAs are targeted to either the PB- or cis-ER, respectively. " RLID00013144 4328969 LOC4328969 http://www.ncbi.nlm.nih.gov/gene/?term=4328969 "OSNPB_020268300, GLUB-4, GluB4, glutelin " mRNA Oryza sativa 24682961 Endoplasmic reticulum Seed Northern blot|RT-PCR "This particle is then exported and moves via the cytoskeleton to the cortical ER. At some point, the complex disassembles and prolamine and glutelin RNAs are targeted to either the PB- or cis-ER, respectively. " RLID00013145 43294 Hmu http://www.ncbi.nlm.nih.gov/gene/?term=43294 "Dmel_CG3373, CG3373, Dmel\CG3373, RRM5, Rbp5, SPH210, rrm5 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013146 432956 D030024E09Rik http://www.ncbi.nlm.nih.gov/gene/?term=432956 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013147 432961 LOC432961 http://www.ncbi.nlm.nih.gov/gene/?term=432961 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013148 4329 ALDH6A1 http://www.ncbi.nlm.nih.gov/gene/?term=4329 "MMSADHA, MMSDH " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013149 432 ASGR1 http://www.ncbi.nlm.nih.gov/gene/?term=432 "ASGPR, ASGPR1, CLEC4H1, HL-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013150 4331 MNAT1 http://www.ncbi.nlm.nih.gov/gene/?term=4331 "CAP35, MAT1, RNF66, TFB3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013151 4331 MNAT1 http://www.ncbi.nlm.nih.gov/gene/?term=4331 "CAP35, MAT1, RNF66, TFB3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013152 433216 Gm5510 http://www.ncbi.nlm.nih.gov/gene/?term=433216 EG433216 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013153 433230 Nsa2-ps1 http://www.ncbi.nlm.nih.gov/gene/?term=433230 "EG433230, Gm19415, Gm5515 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013154 43323 Mlc1 http://www.ncbi.nlm.nih.gov/gene/?term=43323 "Dmel_CG5596, CG5596, DmMLC1, Dmel\CG5596, ELC, FBgn0002772, LC1, MLC, MLC-ALK, MLC1, Mlc-1, MlcI, Mlci, chr3R:23484557..23484663, mlc, mlc-alk, mlc1, mlcl " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013155 43323 Mlc1 http://www.ncbi.nlm.nih.gov/gene/?term=43323 "Dmel_CG5596, CG5596, DmMLC1, Dmel\CG5596, ELC, FBgn0002772, LC1, MLC, MLC-ALK, MLC1, Mlc-1, MlcI, Mlci, chr3R:23484557..23484663, mlc, mlc-alk, mlc1, mlcl " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013156 433256 Acsl5 http://www.ncbi.nlm.nih.gov/gene/?term=433256 "1700030F05Rik, ACS2, ACS5, Facl5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013157 433261 Gm5521 http://www.ncbi.nlm.nih.gov/gene/?term=433261 EG433261 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013158 4333164 LOC4333164 http://www.ncbi.nlm.nih.gov/gene/?term=4333164 "OSNPB_030427300, GLUA-3, GLUA3, Gt22, Gt3, glutelin " mRNA Oryza sativa 24682961 Endoplasmic reticulum Seed Northern blot|RT-PCR "This particle is then exported and moves via the cytoskeleton to the cortical ER. At some point, the complex disassembles and prolamine and glutelin RNAs are targeted to either the PB- or cis-ER, respectively. " RLID00013159 433375 Creg1 http://www.ncbi.nlm.nih.gov/gene/?term=433375 "AA755314, Creg " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013160 433394 LOC433394 http://www.ncbi.nlm.nih.gov/gene/?term=433394 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013161 433406 Gm13363 http://www.ncbi.nlm.nih.gov/gene/?term=433406 OTTMUSG00000011595 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013162 433426 Gm13490 http://www.ncbi.nlm.nih.gov/gene/?term=433426 OTTMUSG00000012405 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013163 433502 Wfdc6b http://www.ncbi.nlm.nih.gov/gene/?term=433502 "WAP6b, Wfdc6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013164 43350 mino http://www.ncbi.nlm.nih.gov/gene/?term=43350 "Dmel_CG5508, 152088_at, BcDNA:GH07066, CG5508, Dmel\CG5508, GPAT1 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013165 43354 Gp93 http://www.ncbi.nlm.nih.gov/gene/?term=43354 "Dmel_CG5520, CG5520, CT17486, Dmel\CG5520, GP93, Hsp90, dGRP94, gp93, p93 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013166 433586 Maml3 http://www.ncbi.nlm.nih.gov/gene/?term=433586 "AV234550, BC049812, Mam-2, mKIAA1816 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013167 433598 Gm5539 http://www.ncbi.nlm.nih.gov/gene/?term=433598 EG433598 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013168 433698 Fam205a1 http://www.ncbi.nlm.nih.gov/gene/?term=433698 "Gm12429, OTTMUSG00000006791 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013169 433702 Ncbp1 http://www.ncbi.nlm.nih.gov/gene/?term=433702 "AU014645, AW538051, CBP80 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013170 43374 Moca-cyp http://www.ncbi.nlm.nih.gov/gene/?term=43374 "Dmel_CG1866, BEST:LD38313, CG1866, Dmel\CG1866, anon-WO0147981.13, anon-WO0147981.4, anon-WO0147981.5, moca " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013171 433759 Hdac1 http://www.ncbi.nlm.nih.gov/gene/?term=433759 "HD1-ps, MommeD5, RPD3, Hdac1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013172 433766 Trim63 http://www.ncbi.nlm.nih.gov/gene/?term=433766 "MuRF1, RF1, Rnf28 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013173 4337 MOCS1 http://www.ncbi.nlm.nih.gov/gene/?term=4337 "MIG11, MOCOD, MOCODA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013174 433844 Gm10482 http://www.ncbi.nlm.nih.gov/gene/?term=433844 "EG433844, ENSMUSG00000073226 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013175 43385 Hrb98DE http://www.ncbi.nlm.nih.gov/gene/?term=43385 "Dmel_CG9983, CG9983, Dmel\CG9983, E7Delta6, HDP(P9), HRB98DE, HRB98DE/hrp38, Hrb1, Hrb98 de/Hrp38, Hrp38, Pen9, anon-E7Delta6, hnRNP A2/B1, hrb98 de, hrb98DE, hrp38, p9, Hrb98DE " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013176 433864 Nom1 http://www.ncbi.nlm.nih.gov/gene/?term=433864 "D5Kng1, Gm1040 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013177 4338 MOCS2 http://www.ncbi.nlm.nih.gov/gene/?term=4338 "MCBPE, MOCO1, MOCODB, MPTS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013178 4339221 LOC4339221 http://www.ncbi.nlm.nih.gov/gene/?term=4339221 "OSNPB_050499100, OJ1057_B02.5 " mRNA Oryza sativa 22168839 Endoplasmic reticulum Endosperm RT-PCR "In situ RT-PCR analysis revealed that α-globulin RNAs are not distributed to the cisternal ER as expected for a PSV-localized protein, but instead are targeted to the protein body-ER (PB-ER) by a regulated process requiring cis-sorting sequences. " RLID00013179 433931 Pigg http://www.ncbi.nlm.nih.gov/gene/?term=433931 Gpi7 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013180 433941 Gm5561 http://www.ncbi.nlm.nih.gov/gene/?term=433941 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013181 43394 CG10000 http://www.ncbi.nlm.nih.gov/gene/?term=43394 "Dmel_ Dmel\CG10000, dppGalNAcT10 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013182 433955 Gm5564 http://www.ncbi.nlm.nih.gov/gene/?term=433955 EG433955 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013183 43402 WASp http://www.ncbi.nlm.nih.gov/gene/?term=43402 "Dmel_CG1520, CG1520, D-WASP, Dm WASP, DmWASP, Dmel\CG1520, WASP, WSP, Wasp, Wsp, dWASP, wasp, wsp " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013184 4341135 LOC4341135 http://www.ncbi.nlm.nih.gov/gene/?term=4341135 "OSNPB_060507200, prolamin " mRNA Oryza sativa 9490759 Ribosome Seed RNA blot "The increase in prolamine mRNA in the soluble fraction of the NaF gradient indicates that ribosome-free prolamine mRNA remains associated with membrane-stripped PBs. These results suggest that ribosome-free prolamine mRNA interacts with a putative RNA-binding activity near or on the PB surface. Overall, these results indicate the presence of a prolamine mRNA-binding activity that requires relatively high ionic-strength levels to release the RNA from the PBs. " RLID00013185 43415 Doa http://www.ncbi.nlm.nih.gov/gene/?term=43415 "Dmel_CG42320, 0844/02, CG1658, CG31049, CG33204, CG33553, CG42320, DOA, DOA/CLK2, Dmel\CG42320, Dmel_CG33204, Dmel_CG33553, Msu, doa, l(3)01705, l(3)S084402, l(3)s2784 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013186 43415 Doa http://www.ncbi.nlm.nih.gov/gene/?term=43415 "Dmel_CG42320, 0844/02, CG1658, CG31049, CG33204, CG33553, CG42320, DOA, DOA/CLK2, Dmel\CG42320, Dmel_CG33204, Dmel_CG33553, Msu, doa, l(3)01705, l(3)S084402, l(3)s2784 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013187 43415 Doa http://www.ncbi.nlm.nih.gov/gene/?term=43415 "Dmel_CG42320, 0844/02, CG1658, CG31049, CG33204, CG33553, CG42320, DOA, DOA/CLK2, Dmel\CG42320, Dmel_CG33204, Dmel_CG33553, Msu, doa, l(3)01705, l(3)S084402, l(3)s2784 " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013188 434178 Zfp141 http://www.ncbi.nlm.nih.gov/gene/?term=434178 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013189 434200 Gm5597 http://www.ncbi.nlm.nih.gov/gene/?term=434200 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013190 434232 Iqck http://www.ncbi.nlm.nih.gov/gene/?term=434232 A230094G09Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013191 434233 Gm5601 http://www.ncbi.nlm.nih.gov/gene/?term=434233 EG434233 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013192 434234 2610020H08Rik http://www.ncbi.nlm.nih.gov/gene/?term=434234 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013193 43426 Cpsf100 http://www.ncbi.nlm.nih.gov/gene/?term=43426 "Dmel_CG1957, BcDNA:LD14168, CG1957, CPSF-100, CPSF100, Dmel\CG1957 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013194 43429 CG11837 http://www.ncbi.nlm.nih.gov/gene/?term=43429 "Dmel_ Dim1, Dmel\CG11837, FBgn0039627 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013195 43439 yem http://www.ncbi.nlm.nih.gov/gene/?term=43439 "Dmel_CG14513, CG11879, CG14513, Dmel\CG14513, Yemalpha, yG4.5, yT4.5-alpha, yema, yemalpha, yem " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013196 4343 MOV10 http://www.ncbi.nlm.nih.gov/gene/?term=4343 "fSAP113, gb110 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013197 434401 Gm5616 http://www.ncbi.nlm.nih.gov/gene/?term=434401 EG434401 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013198 434404 Rps6-ps3 http://www.ncbi.nlm.nih.gov/gene/?term=434404 "EG434404, Gm5618 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013199 434423 Dppa5a http://www.ncbi.nlm.nih.gov/gene/?term=434423 "AA536857, Dppa5, Esg1, ecat2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013200 4345 CD200 http://www.ncbi.nlm.nih.gov/gene/?term=4345 "MOX1, MOX2, MRC, OX-2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013201 43466 stg http://www.ncbi.nlm.nih.gov/gene/?term=43466 "Dmel_CG1395, 0224/06, 0245/03, 0439/22, 0730/13, 0896/05, 0967/05, 0980/06, 1083/13, 1089/08, 1143/02, 5473, CDC25, CDC25[string], CG1395, Cdc25, Cdc25[Stg], Cdc25[String], Cdc25[stg], Cdc25[string], Cdc25c, Dmel\CG1395, EP1213, S(rux)3A, STG, SY3-4, Stg, String/Cdc25, anon-EST:Liang-2.21, cdc25, cdc25[string], clone 2.21, l(3)01235, l(3)j10B9, l(3)j1D3, l(3)j1E3, l(3)j3D1, l(3)s2213, st[cdc25], str/cdc25, stg " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013202 434794 Xlr4a http://www.ncbi.nlm.nih.gov/gene/?term=434794 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013203 43481 alph http://www.ncbi.nlm.nih.gov/gene/?term=43481 "Dmel_CG1906, CG1906, Dmel\CG1906, PP2Cb, SK3-1, pp2c99B " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013204 43483 CG1907 http://www.ncbi.nlm.nih.gov/gene/?term=43483 "Dmel_ CG 1907, Dmel\CG1907 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013205 4348563 LOC4348563 http://www.ncbi.nlm.nih.gov/gene/?term=4348563 "OSNPB_100400200, GLUA-2, GLUA2, Gt1 " mRNA Oryza sativa 24682961 Endoplasmic reticulum Seed Northern blot|RT-PCR "This particle is then exported and moves via the cytoskeleton to the cortical ER. At some point, the complex disassembles and prolamine and glutelin RNAs are targeted to either the PB- or cis-ER, respectively. " RLID00013206 4350 MPG http://www.ncbi.nlm.nih.gov/gene/?term=4350 "AAG, ADPG, APNG, CRA36.1, MDG, Mid1, PIG11, PIG16, anpg " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013207 4350 MPG http://www.ncbi.nlm.nih.gov/gene/?term=4350 "AAG, ADPG, APNG, CRA36.1, MDG, Mid1, PIG11, PIG16, anpg " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013208 4351 MPI http://www.ncbi.nlm.nih.gov/gene/?term=4351 "CDG1B, PMI, PMI1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013209 4351 MPI http://www.ncbi.nlm.nih.gov/gene/?term=4351 "CDG1B, PMI, PMI1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013210 4351 MPI http://www.ncbi.nlm.nih.gov/gene/?term=4351 "CDG1B, PMI, PMI1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013211 43523 neo http://www.ncbi.nlm.nih.gov/gene/?term=43523 "Dmel_CG7802, CG7802, Dmel\CG7802 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013212 4352 MPL http://www.ncbi.nlm.nih.gov/gene/?term=4352 "C-MPL, CD110V, THCYT2, TPOR, MPL " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013213 4352 MPL http://www.ncbi.nlm.nih.gov/gene/?term=4352 "C-MPL, CD110V, THCYT2, TPOR, MPL " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013214 4353 MPO http://www.ncbi.nlm.nih.gov/gene/?term=4353 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013215 4354 MPP1 http://www.ncbi.nlm.nih.gov/gene/?term=4354 "AAG12, DXS552E, EMP55, MRG1, PEMP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013216 4355 MPP2 http://www.ncbi.nlm.nih.gov/gene/?term=4355 DLG2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013217 43560 Nlp http://www.ncbi.nlm.nih.gov/gene/?term=43560 "Dmel_CG7917, CG7917, CRP1, Crp1, Dmel\CG7917, NLP, dNLP, dNLP-S, nlp, p22 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013218 435684 Shf http://www.ncbi.nlm.nih.gov/gene/?term=435684 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013219 43570 Sry-beta http://www.ncbi.nlm.nih.gov/gene/?term=43570 "Dmel_CG7938, CG7938, Dmel\CG7938, Srybeta, ser, sry, sry beta, sry-b, sry-beta, sryb, srybeta " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013220 43570 Sry-beta http://www.ncbi.nlm.nih.gov/gene/?term=43570 "Dmel_CG7938, CG7938, Dmel\CG7938, Srybeta, ser, sry, sry beta, sry-b, sry-beta, sryb, srybeta " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013221 435766 Tnni3k http://www.ncbi.nlm.nih.gov/gene/?term=435766 "Cark, D830019J24Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013222 43588 CG1983 http://www.ncbi.nlm.nih.gov/gene/?term=43588 Dmel_ Dmel\CG1983 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013223 4358 MPV17 http://www.ncbi.nlm.nih.gov/gene/?term=4358 "MTDPS6, SYM1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013224 4358 MPV17 http://www.ncbi.nlm.nih.gov/gene/?term=4358 "MTDPS6, SYM1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013225 43591 CG9747 http://www.ncbi.nlm.nih.gov/gene/?term=43591 Dmel_ Dmel\CG9747 mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013226 43591 CG9747 http://www.ncbi.nlm.nih.gov/gene/?term=43591 Dmel_ Dmel\CG9747 mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013227 435 ASL http://www.ncbi.nlm.nih.gov/gene/?term=435 ASAL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013228 435 ASL http://www.ncbi.nlm.nih.gov/gene/?term=435 ASAL mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013229 4361 MRE11A http://www.ncbi.nlm.nih.gov/gene/?term=4361 "ATLD, HNGS1, MRE11, MRE11B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013230 43633 tmod http://www.ncbi.nlm.nih.gov/gene/?term=43633 "Dmel_CG1539, 1309/10, CG11493, CG1539, CG15540, CT3919, CT41421, Dmel\CG1539, E42, Tmod, l(3)00848, l(3)S130910, spdo " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013231 43633 tmod http://www.ncbi.nlm.nih.gov/gene/?term=43633 "Dmel_CG1539, 1309/10, CG11493, CG1539, CG15540, CT3919, CT41421, Dmel\CG1539, E42, Tmod, l(3)00848, l(3)S130910, spdo " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013232 4363 ABCC1 http://www.ncbi.nlm.nih.gov/gene/?term=4363 "ABC29, ABCC, GS-X, MRP, MRP1 " mRNA Homo sapiens 21854988 Mitochondrion - Next-generation sequencing "Firstly, to validate the two-phase sequencing approach, we considered three noncoding RNAs (ncRNAs), 5S rRNA, MRP and RNase P, that have been previously shown to be present in the mitochondrial matrix (Wang et al., 2010), finding all transcripts, though lowly expressed, enriched in mitoplasts (Figure S2D). " RLID00013233 43640 PH4alphaPV http://www.ncbi.nlm.nih.gov/gene/?term=43640 "Dmel_CG31015, CG31015, CG9713, Dmel\CG31015 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013234 43648 Npc2g http://www.ncbi.nlm.nih.gov/gene/?term=43648 "Dmel_CG11314, BcDNA:RE56164, CG11314, Dmel\CG11314, npc2g " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013235 43649 Npc2h http://www.ncbi.nlm.nih.gov/gene/?term=43649 "Dmel_CG11315, BcDNA:GH26608, BcDNA:RH04252, BcDNA:RH68460, CG11315, DmML1A, Dmel\CG11315, npc2h " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013236 43650 zfh1 http://www.ncbi.nlm.nih.gov/gene/?term=43650 "Dmel_CG1322, CG1322, Dmel\CG1322, ZFH-1, ZFH1, Zfh-1, Zfh1, Zfh1a, l(3)00865, zfh-1, zfl-1, zhf1 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00013237 43654 cindr http://www.ncbi.nlm.nih.gov/gene/?term=43654 "Dmel_CG31012, BcDNA:GH03163, CD2AP, CG11316, CG1408, CG31012, Cindr, Dmel\CG31012 " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013238 43662 Sap-r http://www.ncbi.nlm.nih.gov/gene/?term=43662 "Dmel_CG12070, Apa, BcDNA:GH08312, CG12070, DAPA, Dmel\CG12070, Ov9, P110, Sap-R, Sapr, anon-EST:ParkEST270, sap-r " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013239 43694 CG12054 http://www.ncbi.nlm.nih.gov/gene/?term=43694 Dmel_ Dmel\CG12054 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013240 43749 faf http://www.ncbi.nlm.nih.gov/gene/?term=43749 "Dmel_CG1945, BcDNA.LD22582, BcDNA:LD22582, CG1945, Dmel\CG1945, Faf, Fat, P55824 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013241 43772 CG2316 http://www.ncbi.nlm.nih.gov/gene/?term=43772 Dmel_ Dmel\CG2316 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013242 43775 Crk http://www.ncbi.nlm.nih.gov/gene/?term=43775 "Dmel_CG1587, CG1587, CRK, D-CRK, D-Crk, DCrk, Dcrk, Dmel\CG1587, crk, dCRK, dCrk " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013243 43777 CG31999 http://www.ncbi.nlm.nih.gov/gene/?term=43777 "Dmel_ CG10323, CG11288, CT31491, CT7856, Dmel\CG31999 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013244 43786 Zip102B http://www.ncbi.nlm.nih.gov/gene/?term=43786 "Dmel_CG2177, CG2177, Dmel\CG2177, cg2177, dZip102B " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013245 43788 Hcf http://www.ncbi.nlm.nih.gov/gene/?term=43788 "Dmel_CG1710, CG1710, Dmel\CG1710, HCF, HCF1, HCF_DROME1, anon-WO0172774.48, dHCF, dHcf, dHcf1, Hcf " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00013246 43792 CaMKI http://www.ncbi.nlm.nih.gov/gene/?term=43792 "Dmel_CG1495, CG1495, Calcium/calmodulin-dependent protein kinase, CamKI, Dmel\CG1495, caMKI, camKI, dCKI " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013247 43793 bip2 http://www.ncbi.nlm.nih.gov/gene/?term=43793 "Dmel_CG2009, BIP2, Bip2, CG2009, DmTAF3, Dmel\CG2009, TAF155, TAF3, TAFII155, TAF[[II]]155, TFIID, bip-II, dBIP2, dTAFII3, dTAF[[II]]155, dmTAF3, i163, i31 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). These 27 genes came from TABLE 1. " RLID00013248 43797 Pur-alpha http://www.ncbi.nlm.nih.gov/gene/?term=43797 "Dmel_CG1507, CG1507, Dmel\CG1507, PURalpha, Pur alpha, Pur-a, dPur alpha, pur-alpha " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013249 43797 Pur-alpha http://www.ncbi.nlm.nih.gov/gene/?term=43797 "Dmel_CG1507, CG1507, Dmel\CG1507, PURalpha, Pur alpha, Pur-a, dPur alpha, pur-alpha " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013250 4379919 CG17698 http://www.ncbi.nlm.nih.gov/gene/?term=4379919 "Dmel_ CAMKIIB, CAMKIIb, CG40297, Dmel\CG17698 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013251 4379919 CG17698 http://www.ncbi.nlm.nih.gov/gene/?term=4379919 "Dmel_ CAMKIIB, CAMKIIb, CG40297, Dmel\CG17698 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013252 43804 mav http://www.ncbi.nlm.nih.gov/gene/?term=43804 "Dmel_CG1901, CG1901, Dmel\CG1901, MAV, Mav, TGF-b " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013253 43804 mav http://www.ncbi.nlm.nih.gov/gene/?term=43804 "Dmel_CG1901, CG1901, Dmel\CG1901, MAV, Mav, TGF-b " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013254 43811 myo http://www.ncbi.nlm.nih.gov/gene/?term=43811 "Dmel_CG1838, BcDNA:LD02307, CG1838, Dmel\CG1838, MYO, Myo, Myoglianin, myg " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013255 43816 MED26 http://www.ncbi.nlm.nih.gov/gene/?term=43816 "Dmel_CG1793, ARC 70, Arc70, CG1793, CG1823, Dmel\CG1793, Med26, dARC70 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00013256 43816 MED26 http://www.ncbi.nlm.nih.gov/gene/?term=43816 "Dmel_CG1793, ARC 70, Arc70, CG1793, CG1823, Dmel\CG1793, Med26, dARC70 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013257 43816 MED26 http://www.ncbi.nlm.nih.gov/gene/?term=43816 "Dmel_CG1793, ARC 70, Arc70, CG1793, CG1823, Dmel\CG1793, Med26, dARC70 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013258 43819 pho http://www.ncbi.nlm.nih.gov/gene/?term=43819 "Dmel_CG17743, CG17743, Dmel\CG17743, PHO, PHO/YY1, Pho, YY1, dYY1, l(4)102EFc, l(4)29, l(4)BU-2, l(4)OC-1, l(4)pho " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013259 43823 Arf102F http://www.ncbi.nlm.nih.gov/gene/?term=43823 "Dmel_CG11027, ARF2, ARFII, Arf102E, Arf4, Arf5, CG11027, Dmel\CG11027, P40945, arf102F, dARFII " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013260 43830 CG11076 http://www.ncbi.nlm.nih.gov/gene/?term=43830 Dmel_ Dmel\CG11076 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013261 43830 CG11076 http://www.ncbi.nlm.nih.gov/gene/?term=43830 Dmel_ Dmel\CG11076 mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013262 43839 eIF4G http://www.ncbi.nlm.nih.gov/gene/?term=43839 "Dmel_CG10811, CG10811, Dmel\CG10811, EIF4G, Eif4G, deIF4G, eIF-4G, eIF4g, p200 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013263 43906 skd http://www.ncbi.nlm.nih.gov/gene/?term=43906 "Dmel_CG9936, CG9936, Dmel\CG9936, LD28662, MED13, Med13, Pap, Pap/Trap, SPH203, Scad78, Skd, Skd/Med13, Skd/Pap/Bli, Srb9/AMIB/PAP/TRAP240, TRAP240, Trap240, bli, bls, dMED13, dTRAP240, dTrap240, dmMED13, l(3)L7062, l(3)rK760, pap, pap/dTRAP240, siren9 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013264 43906 skd http://www.ncbi.nlm.nih.gov/gene/?term=43906 "Dmel_CG9936, CG9936, Dmel\CG9936, LD28662, MED13, Med13, Pap, Pap/Trap, SPH203, Scad78, Skd, Skd/Med13, Skd/Pap/Bli, Srb9/AMIB/PAP/TRAP240, TRAP240, Trap240, bli, bls, dMED13, dTRAP240, dTrap240, dmMED13, l(3)L7062, l(3)rK760, pap, pap/dTRAP240, siren9 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013265 43934 gom http://www.ncbi.nlm.nih.gov/gene/?term=43934 "Dmel_CG6727, CG6727, Dmel\CG6727 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013266 43934 gom http://www.ncbi.nlm.nih.gov/gene/?term=43934 "Dmel_CG6727, CG6727, Dmel\CG6727 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013267 43934 gom http://www.ncbi.nlm.nih.gov/gene/?term=43934 "Dmel_CG6727, CG6727, Dmel\CG6727 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013268 43936 Men-b http://www.ncbi.nlm.nih.gov/gene/?term=43936 "Dmel_CG5889, CG5889, Dmel\CG5889, MDH, Mdh, anon-EST:Posey79 " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013269 43981 DIP1 http://www.ncbi.nlm.nih.gov/gene/?term=43981 "Dmel_CG17686, CG17686, Dmel\CG17686, TO34, TO67, UbxBP1, clot 10495, clot 2020, dip1, dip1a, klt " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013270 43981 DIP1 http://www.ncbi.nlm.nih.gov/gene/?term=43981 "Dmel_CG17686, CG17686, Dmel\CG17686, TO34, TO67, UbxBP1, clot 10495, clot 2020, dip1, dip1a, klt " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013271 439921 MXRA7 http://www.ncbi.nlm.nih.gov/gene/?term=439921 "PS1TP1, TMAP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013272 439921 MXRA7 http://www.ncbi.nlm.nih.gov/gene/?term=439921 "PS1TP1, TMAP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013273 439921 MXRA7 http://www.ncbi.nlm.nih.gov/gene/?term=439921 "PS1TP1, TMAP1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013274 439921 MXRA7 http://www.ncbi.nlm.nih.gov/gene/?term=439921 "PS1TP1, TMAP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013275 43997 jbug http://www.ncbi.nlm.nih.gov/gene/?term=43997 "Dmel_CG30092, AAF46896, CG11605, CG13525, CG30092, CG3550, Dmel\CG30092, Jbug " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013276 43997 jbug http://www.ncbi.nlm.nih.gov/gene/?term=43997 "Dmel_CG30092, AAF46896, CG11605, CG13525, CG30092, CG3550, Dmel\CG30092, Jbug " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013277 43999 trbl http://www.ncbi.nlm.nih.gov/gene/?term=43999 "Dmel_CG5408, CG5408, Dmel\CG5408, Trbl, trb " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013278 439 ASNA1 http://www.ncbi.nlm.nih.gov/gene/?term=439 "ARSA-I, ARSA1, ASNA-I, GET3, TRC40, hASNA-I " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013279 439 ASNA1 http://www.ncbi.nlm.nih.gov/gene/?term=439 "ARSA-I, ARSA1, ASNA-I, GET3, TRC40, hASNA-I " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013280 43 ACHE http://www.ncbi.nlm.nih.gov/gene/?term=43 "ACEE, ARACHE, N-ACHE, YT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013281 440026 TMEM41B http://www.ncbi.nlm.nih.gov/gene/?term=440026 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013282 44007 COQ7 http://www.ncbi.nlm.nih.gov/gene/?term=44007 "Dmel_CG14437, CG14437, Dclk1, Dmel\CG14437 " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013283 440081 DDX12P http://www.ncbi.nlm.nih.gov/gene/?term=440081 "CHLR2, DDX12 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013284 440087 SMCO3 http://www.ncbi.nlm.nih.gov/gene/?term=440087 C12orf69 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013285 440093 H3F3C http://www.ncbi.nlm.nih.gov/gene/?term=440093 H3.5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013286 440138 ALG11 http://www.ncbi.nlm.nih.gov/gene/?term=440138 "CDG1P, GT8 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013287 440145 MZT1 http://www.ncbi.nlm.nih.gov/gene/?term=440145 "C13orf37, MOZART1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013288 440145 MZT1 http://www.ncbi.nlm.nih.gov/gene/?term=440145 "C13orf37, MOZART1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013289 44018 cas http://www.ncbi.nlm.nih.gov/gene/?term=44018 "Dmel_CG2102, CG2102, Cas, Dmel\CG2102, l(3)j1C2, l(3)neo33, ming " mRNA Drosophila melanogaster 17923096 Nucleus Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00013290 44018 cas http://www.ncbi.nlm.nih.gov/gene/?term=44018 "Dmel_CG2102, CG2102, Cas, Dmel\CG2102, l(3)j1C2, l(3)neo33, ming " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013291 44018 cas http://www.ncbi.nlm.nih.gov/gene/?term=44018 "Dmel_CG2102, CG2102, Cas, Dmel\CG2102, l(3)j1C2, l(3)neo33, ming " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013292 44018 cas http://www.ncbi.nlm.nih.gov/gene/?term=44018 "Dmel_CG2102, CG2102, Cas, Dmel\CG2102, l(3)j1C2, l(3)neo33, ming " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013293 440193 CCDC88C http://www.ncbi.nlm.nih.gov/gene/?term=440193 "DAPLE, HKRP2, KIAA1509, SCA40 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013294 44021 nmd http://www.ncbi.nlm.nih.gov/gene/?term=44021 "Dmel_CG5395, CG5395, DmCG5395, Dmel\CG5395, Msp, Msp1, Nmd, anon-EST:Liang-1.79, clone 1.79, l(2)08774, ms(2)4, ms(2)ry4 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013295 440275 EIF2AK4 http://www.ncbi.nlm.nih.gov/gene/?term=440275 "GCN2, PVOD2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013296 440275 EIF2AK4 http://www.ncbi.nlm.nih.gov/gene/?term=440275 "GCN2, PVOD2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013297 440275 EIF2AK4 http://www.ncbi.nlm.nih.gov/gene/?term=440275 "GCN2, PVOD2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013298 440335 SMIM22 http://www.ncbi.nlm.nih.gov/gene/?term=440335 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013299 440348 NPIPB15 http://www.ncbi.nlm.nih.gov/gene/?term=440348 "A-761H5.4, NPIPL2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013300 440456 PLEKHM1P1 http://www.ncbi.nlm.nih.gov/gene/?term=440456 PLEKHM1P lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013301 440498 HSBP1L1 http://www.ncbi.nlm.nih.gov/gene/?term=440498 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013302 44054 Ubc7 http://www.ncbi.nlm.nih.gov/gene/?term=44054 "Dmel_CG4443, CG4443, Crl, Dmel\CG4443, UBC7, Ubc47D, col, crl " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013303 44054 Ubc7 http://www.ncbi.nlm.nih.gov/gene/?term=44054 "Dmel_CG4443, CG4443, Crl, Dmel\CG4443, UBC7, Ubc47D, col, crl " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013304 440574 MINOS1 http://www.ncbi.nlm.nih.gov/gene/?term=440574 "C1orf151, MIO10, Mic10 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013305 440574 MINOS1 http://www.ncbi.nlm.nih.gov/gene/?term=440574 "C1orf151, MIO10, Mic10 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013306 44059 RpL30 http://www.ncbi.nlm.nih.gov/gene/?term=44059 "Dmel_CG10652, BcDNA:RE25263, BcDNA:RH09938, CG10652, Dmel\CG10652, L30, RPL30, Rp L30, Rpl30, anon-EST:fe1D4, l(2)01265, l(2)SH0229, l(2)SH2 0229, l(2)k09918, plume " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013307 440603 BCL2L15 http://www.ncbi.nlm.nih.gov/gene/?term=440603 "Bfk, C1orf178 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013308 440603 BCL2L15 http://www.ncbi.nlm.nih.gov/gene/?term=440603 "Bfk, C1orf178 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013309 440672 NUDT4P1 http://www.ncbi.nlm.nih.gov/gene/?term=440672 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013310 440689 HIST2H2BF http://www.ncbi.nlm.nih.gov/gene/?term=440689 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013311 440712 C1orf186 http://www.ncbi.nlm.nih.gov/gene/?term=440712 RHEX mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013312 440738 MAP1LC3C http://www.ncbi.nlm.nih.gov/gene/?term=440738 "ATG8J, LC3C " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013313 440738 MAP1LC3C http://www.ncbi.nlm.nih.gov/gene/?term=440738 "ATG8J, LC3C " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013314 440822 PIWIL3 http://www.ncbi.nlm.nih.gov/gene/?term=440822 HIWI3 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013315 440822 PIWIL3 http://www.ncbi.nlm.nih.gov/gene/?term=440822 HIWI3 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013316 440823 MIAT http://www.ncbi.nlm.nih.gov/gene/?term=440823 "C22orf35, GOMAFU, LINC00066, NCRNA00066, RNCR2, lncRNA-MIAT " lncRNA Homo sapiens 25332394 Nucleus - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/gomafu/ RLID00013317 440823 MIAT http://www.ncbi.nlm.nih.gov/gene/?term=440823 "C22orf35, GOMAFU, LINC00066, NCRNA00066, RNCR2, lncRNA-MIAT " lncRNA Homo sapiens 21128942 Nucleus Brain tissue qRT-PCR|Microarray Table 2: Long noncoding RNAs represented on Affymetrix U133 arrays that were reliably detected in human nucleus accumbens. An lncRNA was considered reliably detected in human NAcc if at least one probe corresponding to the transcript gave a specific signal in all control subjects. No transcripts undetected in the controls were consistently detected in drug abusers. Data are collected from Talbe 2. RLID00013318 440823 MIAT http://www.ncbi.nlm.nih.gov/gene/?term=440823 "C22orf35, GOMAFU, LINC00066, NCRNA00066, RNCR2, lncRNA-MIAT " lncRNA Homo sapiens 25690653 Nucleus P493-6 cell qRT-PCR "To validate the isolation of nuclear and cytoplasmic fractions, the enrichment of 3 nuclear (ANRIL, MIAT, XIST) and 3 cytoplasmic (RPPH1, DANCR, tRNA-Lys) RNAs was analyzed by qRT-PCR. " RLID00013319 440823 MIAT http://www.ncbi.nlm.nih.gov/gene/?term=440823 "C22orf35, GOMAFU, LINC00066, NCRNA00066, RNCR2, lncRNA-MIAT " lncRNA Homo sapiens 22955988 Nucleus Brain Microarray "We examined the subcellular location of a number of well-known lncRNAs (Fig. 8D). Unsurprisingly, the X-chromosome inactivating transcript XIST was extremely highly enriched in the nucleus for all cells we examined (with a maximum enrichment of 273-fold in the nucleus of GM12878 cells) (Fig. 8D). Other regulatory lncRNAs such as GAS5, LINC00568 (also known as ncRNA-a1), CYP4A22-AS1 (also known as ncRNA-a3), MIAT, and MEG3 were nuclear enriched in at least two different cell types, consistent with their reported roles in gene regulation. Other transcripts, including the bifunctional transcript SRA1, which acts as both a regulatory RNA and a protein-coding sequence, have more variable subcellular location depending on cell type. As reported previously, the H19 transcript is consistently enriched in the cytoplasm, especially when comparing with the chromatin fraction (cytoplasmic/chromatin enrichment 167-fold). " RLID00013320 440957 SMIM4 http://www.ncbi.nlm.nih.gov/gene/?term=440957 C3orf78 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013321 440 ASNS http://www.ncbi.nlm.nih.gov/gene/?term=440 "ASNSD, TS11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013322 440 ASNS http://www.ncbi.nlm.nih.gov/gene/?term=440 "ASNSD, TS11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013323 44100 Patj http://www.ncbi.nlm.nih.gov/gene/?term=44100 "Dmel_CG12021, BcDNA:LD22238, CG12021, D-Patj, DLT, DPATJ, DPatj, Dlt, Dmel\CG12021, Dpatj, PATJ, PaTJ, PatJ/Dlt, dPATJ, dPatj, dlt, dlt:discs lost, dpatj, patj " mRNA Drosophila melanogaster 17923096 Cell junction Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00013324 44100 Patj http://www.ncbi.nlm.nih.gov/gene/?term=44100 "Dmel_CG12021, BcDNA:LD22238, CG12021, D-Patj, DLT, DPATJ, DPatj, Dlt, Dmel\CG12021, Dpatj, PATJ, PaTJ, PatJ/Dlt, dPATJ, dPatj, dlt, dlt:discs lost, dpatj, patj " mRNA Drosophila melanogaster 17923096 Cytoskeleton Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00013325 441024 MTHFD2L http://www.ncbi.nlm.nih.gov/gene/?term=441024 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013326 441027 TMEM150C http://www.ncbi.nlm.nih.gov/gene/?term=441027 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013327 441191 RNF216P1 http://www.ncbi.nlm.nih.gov/gene/?term=441191 "RNF216L, hCG2040556 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013328 441273 SPDYE2 http://www.ncbi.nlm.nih.gov/gene/?term=441273 SPDYB2-L1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013329 44131 Mkrn1 http://www.ncbi.nlm.nih.gov/gene/?term=44131 "Dmel_CG7184, CG7184, Dmel\CG7184, MKRN1 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013330 44131 Mkrn1 http://www.ncbi.nlm.nih.gov/gene/?term=44131 "Dmel_CG7184, CG7184, Dmel\CG7184, MKRN1 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013331 441478 NRARP http://www.ncbi.nlm.nih.gov/gene/?term=441478 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013332 441478 NRARP http://www.ncbi.nlm.nih.gov/gene/?term=441478 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013333 441478 NRARP http://www.ncbi.nlm.nih.gov/gene/?term=441478 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013334 44149 Acon http://www.ncbi.nlm.nih.gov/gene/?term=44149 "Dmel_CG9244, ACON-1M, BEST:GH10550, CG9244, Dmel\CG9244, FBgn0010100, M-Acon, acon, hsp60, i204, i59, l(2)07054, m-Acon, m-acon, mACON, mAc, mAcon, Acon " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013335 441520 CT45A4 http://www.ncbi.nlm.nih.gov/gene/?term=441520 "CT45-4, CT45.4 " mRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00013336 441531 PGAM4 http://www.ncbi.nlm.nih.gov/gene/?term=441531 "PGAM-B, PGAM1, PGAM3, dJ1000K24.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013337 441631 TSPAN11 http://www.ncbi.nlm.nih.gov/gene/?term=441631 VSSW1971 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013338 441733 PRKXP1 http://www.ncbi.nlm.nih.gov/gene/?term=441733 lncRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013339 441951 ZFAS1 http://www.ncbi.nlm.nih.gov/gene/?term=441951 "C20orf199, HSUP1, HSUP2, NCRNA00275, ZNFX1-AS1 " lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013340 441951 ZFAS1 http://www.ncbi.nlm.nih.gov/gene/?term=441951 "C20orf199, HSUP1, HSUP2, NCRNA00275, ZNFX1-AS1 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013341 44227 Fatp http://www.ncbi.nlm.nih.gov/gene/?term=44227 "Dmel_CG7400, CG7400, Dmel\CG7400, Dromel_CG7400_FBtr0080133_fatp_mORF, anon-WO0121795.74, dFATP, dFatp, fatp, l(2)k10307 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013342 44227 Fatp http://www.ncbi.nlm.nih.gov/gene/?term=44227 "Dmel_CG7400, CG7400, Dmel\CG7400, Dromel_CG7400_FBtr0080133_fatp_mORF, anon-WO0121795.74, dFATP, dFatp, fatp, l(2)k10307 " mRNA Drosophila melanogaster 25838129 Apical Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013343 44227 Fatp http://www.ncbi.nlm.nih.gov/gene/?term=44227 "Dmel_CG7400, CG7400, Dmel\CG7400, Dromel_CG7400_FBtr0080133_fatp_mORF, anon-WO0121795.74, dFATP, dFatp, fatp, l(2)k10307 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013344 44258 ps http://www.ncbi.nlm.nih.gov/gene/?term=44258 "Dmel_CG42670, BcDNA:RE47781, CG16765, CG16776, CG16777, CG18509, CG42670, CG8144, Dmel\CG42670, Dmel_CG16765, Dmel_CG16777, EP(3)3406, NOVA1, PS, cg8144, l(3)10615 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013345 44258 ps http://www.ncbi.nlm.nih.gov/gene/?term=44258 "Dmel_CG42670, BcDNA:RE47781, CG16765, CG16776, CG16777, CG18509, CG42670, CG8144, Dmel\CG42670, Dmel_CG16765, Dmel_CG16777, EP(3)3406, NOVA1, PS, cg8144, l(3)10615 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013346 44275 SoxN http://www.ncbi.nlm.nih.gov/gene/?term=44275 "Dmel_CG18024, CG18024, DM64, Dmel\CG18024, SOX29F, SOXB1, Sox B1, Sry-rDM64, soxN " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013347 44275 SoxN http://www.ncbi.nlm.nih.gov/gene/?term=44275 "Dmel_CG18024, CG18024, DM64, Dmel\CG18024, SOX29F, SOXB1, Sox B1, Sry-rDM64, soxN " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013348 442802 C330011M18Rik http://www.ncbi.nlm.nih.gov/gene/?term=442802 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013349 44289 flw http://www.ncbi.nlm.nih.gov/gene/?term=44289 "Dmel_CG2096, CG15305, CG2096, DmPp1-9C, Dmel\CG2096, FLW, FLW/PP1B, PP-1, PP1, PP1 9C, PP1 b9C, PP1 beta9c, PP19C, PP1B_DROME, PP1beta, PP1beta-9C, PP1beta9C, PP1c, PP1cbeta, Pp1-9C, Pp1beta-9C, Pp1beta9C, XE55, anon-WO03040301.120, l(1)G0172 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013350 44289 flw http://www.ncbi.nlm.nih.gov/gene/?term=44289 "Dmel_CG2096, CG15305, CG2096, DmPp1-9C, Dmel\CG2096, FLW, FLW/PP1B, PP-1, PP1, PP1 9C, PP1 b9C, PP1 beta9c, PP19C, PP1B_DROME, PP1beta, PP1beta-9C, PP1beta9C, PP1c, PP1cbeta, Pp1-9C, Pp1beta-9C, Pp1beta9C, XE55, anon-WO03040301.120, l(1)G0172 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013351 44291 Idh http://www.ncbi.nlm.nih.gov/gene/?term=44291 "Dmel_CG7176, CG7176, CT22171, Dmel\CG7176, ICDH, IDH, IDH-NADP-NADP, cIdh, idh, isocitrate dehydrogenase, l(3)L3852, Idh " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013352 4430 MYO1B http://www.ncbi.nlm.nih.gov/gene/?term=4430 myr1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013353 4430 MYO1B http://www.ncbi.nlm.nih.gov/gene/?term=4430 myr1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013354 443595 tuft1 http://www.ncbi.nlm.nih.gov/gene/?term=443595 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00013355 4435 CITED1 http://www.ncbi.nlm.nih.gov/gene/?term=4435 MSG1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013356 4435 CITED1 http://www.ncbi.nlm.nih.gov/gene/?term=4435 MSG1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013357 443626 mprip http://www.ncbi.nlm.nih.gov/gene/?term=443626 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00013358 4436 MSH2 http://www.ncbi.nlm.nih.gov/gene/?term=4436 "COCA1, FCC1, HNPCC, HNPCC1, LCFS2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013359 443868 cnksr2 http://www.ncbi.nlm.nih.gov/gene/?term=443868 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00013360 4439 MSH5 http://www.ncbi.nlm.nih.gov/gene/?term=4439 "G7, MUTSH5, NG23 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013361 444146 rtn3-a http://www.ncbi.nlm.nih.gov/gene/?term=444146 "XRTN3, asyip, hap, nspl2, nsplii, rtn31, rtn3-a " mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00013362 444 ASPH http://www.ncbi.nlm.nih.gov/gene/?term=444 "AAH, BAH, CASQ2BP1, FDLAB, HAAH, JCTN, junctin " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013363 444 ASPH http://www.ncbi.nlm.nih.gov/gene/?term=444 "AAH, BAH, CASQ2BP1, FDLAB, HAAH, JCTN, junctin " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013364 44505 br http://www.ncbi.nlm.nih.gov/gene/?term=44505 "Dmel_CG11491, 2B5, 2Bc, A18, BR, BR-C, BR-C Z1, BR-c, BRC, BRC-Z1, BRC-Z2, BRC-Z3, BRC-Z4, BR_C, Br, Br-C, Br-C Z2, Br-C-Z3, Br-Z4, BrC, BrC-Z1, BrZ3, CG11491, CG11509, CG11511, CG11514, Dmel\CG11491, Dmel_CG11509, EG:123F11.1, EG:17A9.1, EG:25D2.1, PP1, PP2, Z1, Z2, Z3, Z4-C, br-Z1, br-Z2, br-Z3, br-Z4, de12, ecs, l(1)2Ba, l(1)2Bab, l(1)2Bad, l(1)2Bb, l(1)2Bc, l(1)2Bd, l(1)ESHS5, l(1)G0018, l(1)G0042, l(1)G0284, l(1)G0284a, l(1)G0318, l(1)G0401, l(1)PP1, l(1)d norm-12, l(1)d.norm.1, l(1)dn1, l(1)n34, l(1)npr-1, l(1)npr1, l(1)pp-1, l(1)pp-2, l(1)pp1, l(1)pp2, l(1)ts132, l(1)ts144, l(1)ts358, l(1)ts376, npr, npr-1, npr1, nprl, nrp, nrp1, o.c.c., rbp, rdp, rds, uq, br " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013365 445329 SULT1A4 http://www.ncbi.nlm.nih.gov/gene/?term=445329 "HAST3, M-PST, ST1A3/ST1A4, ST1A4, TL-PST " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013366 44540 ct http://www.ncbi.nlm.nih.gov/gene/?term=44540 "Dmel_CG11387, BcDNA:GH10590, CG11387, CT, CUT, Ct, Cut, Dmel\CG11387, kf, l(1)7Ba, l(1)7Bb, l(1)VE614 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013367 44540 ct http://www.ncbi.nlm.nih.gov/gene/?term=44540 "Dmel_CG11387, BcDNA:GH10590, CG11387, CT, CUT, Ct, Cut, Dmel\CG11387, kf, l(1)7Ba, l(1)7Bb, l(1)VE614 " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013368 44540 ct http://www.ncbi.nlm.nih.gov/gene/?term=44540 "Dmel_CG11387, BcDNA:GH10590, CG11387, CT, CUT, Ct, Cut, Dmel\CG11387, kf, l(1)7Ba, l(1)7Bb, l(1)VE614 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013369 44548 lola http://www.ncbi.nlm.nih.gov/gene/?term=44548 "Dmel_CG12052, BEST:LD03274, BTB-IV, BcDNA:LD17006, BcDNA:RH31485, BtbIV, CG12052, CG18376, CG18378, CG18379, CG18380, CG18381, CG30012, CG30013, CG30014, Dmel\CG12052, LD03274, Lola, NEST:bs06a08, bs06a08.y1, eyeful, fus7, l(2)00642, l(2)s3697, sw59 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013370 44548 lola http://www.ncbi.nlm.nih.gov/gene/?term=44548 "Dmel_CG12052, BEST:LD03274, BTB-IV, BcDNA:LD17006, BcDNA:RH31485, BtbIV, CG12052, CG18376, CG18378, CG18379, CG18380, CG18381, CG30012, CG30013, CG30014, Dmel\CG12052, LD03274, Lola, NEST:bs06a08, bs06a08.y1, eyeful, fus7, l(2)00642, l(2)s3697, sw59 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013371 44548 lola http://www.ncbi.nlm.nih.gov/gene/?term=44548 "Dmel_CG12052, BEST:LD03274, BTB-IV, BcDNA:LD17006, BcDNA:RH31485, BtbIV, CG12052, CG18376, CG18378, CG18379, CG18380, CG18381, CG30012, CG30013, CG30014, Dmel\CG12052, LD03274, Lola, NEST:bs06a08, bs06a08.y1, eyeful, fus7, l(2)00642, l(2)s3697, sw59 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013372 445571 CBWD3 http://www.ncbi.nlm.nih.gov/gene/?term=445571 bA561O23.1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013373 445 ASS1 http://www.ncbi.nlm.nih.gov/gene/?term=445 "ASS, CTLN1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013374 445 ASS1 http://www.ncbi.nlm.nih.gov/gene/?term=445 "ASS, CTLN1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013375 446296 pcsk6 http://www.ncbi.nlm.nih.gov/gene/?term=446296 "PACE4, PACE4AIIa, Xpace4, spc4 " mRNA Xenopus laevis 15634697 Mitochondrion Oocyte Whole mount In Situ Hybridization Whole-mount in situ hybridization shows that XPACE4 is localized during early oogenesis. Inset shows XPACE4 mRNA localization in the mitochondrial cloud of stage 1 oocytes. RLID00013376 446692 triobp http://www.ncbi.nlm.nih.gov/gene/?term=446692 tara mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00013377 446697 jak1 http://www.ncbi.nlm.nih.gov/gene/?term=446697 mRNA Xenopus laevis 25988600 Nucleus Spermatogonial stem cell In situ hybridization "When these barrel-shaped PGs were stained by in situ hybridization with JAK1-antisense probe, followed by propidium iodide staining, they were found to possess two nuclei. JAK1 mRNA were localized in a cell region wherein only one nucleus occurred (Fig. 8A� A� B� B�. " RLID00013378 446711 nrf1 http://www.ncbi.nlm.nih.gov/gene/?term=446711 "alpha-pal, nrf-1 " mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00013379 446899 fndc3a.2 http://www.ncbi.nlm.nih.gov/gene/?term=446899 "fndc3, hugo " mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00013380 447159 MGC85478 http://www.ncbi.nlm.nih.gov/gene/?term=447159 mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00013381 447246 sybu http://www.ncbi.nlm.nih.gov/gene/?term=447246 "golsyn, ocsyn, snphl " mRNA Xenopus laevis 24798204 Vegetal Oocyte In situ hybridization "In oocytes, syntabulin transcripts were localized to the vegetal cortex of large oocytes and the mitochondrial cloud of very young oocytes. We extended the zebrafish data by finding that during cleavage Xenopus syntabulin mRNA localized to the germ plasm and was later expressed in primordial germ cells (PGCs). " RLID00013382 447246 sybu http://www.ncbi.nlm.nih.gov/gene/?term=447246 "golsyn, ocsyn, snphl " mRNA Xenopus laevis 24798204 Germ plasm Oocyte In situ hybridization "In oocytes, syntabulin transcripts were localized to the vegetal cortex of large oocytes and the mitochondrial cloud of very young oocytes. We extended the zebrafish data by finding that during cleavage Xenopus syntabulin mRNA localized to the germ plasm and was later expressed in primordial germ cells (PGCs). " RLID00013383 447246 sybu http://www.ncbi.nlm.nih.gov/gene/?term=447246 "golsyn, ocsyn, snphl " mRNA Xenopus laevis 24798204 Mitochondrion Oocyte In situ hybridization "In oocytes, syntabulin transcripts were localized to the vegetal cortex of large oocytes and the mitochondrial cloud of very young oocytes. We extended the zebrafish data by finding that during cleavage Xenopus syntabulin mRNA localized to the germ plasm and was later expressed in primordial germ cells (PGCs). " RLID00013384 447246 sybu http://www.ncbi.nlm.nih.gov/gene/?term=447246 "golsyn, ocsyn, snphl " mRNA Xenopus laevis 24798204 Germ plasm Germ cell In situ hybridization "In oocytes, syntabulin transcripts were localized to the vegetal cortex of large oocytes and the mitochondrial cloud of very young oocytes. We extended the zebrafish data by finding that during cleavage Xenopus syntabulin mRNA localized to the germ plasm and was later expressed in primordial germ cells (PGCs). " RLID00013385 447365 MGC84194 http://www.ncbi.nlm.nih.gov/gene/?term=447365 mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00013386 447459 zfand3 http://www.ncbi.nlm.nih.gov/gene/?term=447459 mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00013387 44747 msk http://www.ncbi.nlm.nih.gov/gene/?term=44747 "Dmel_CG7935, 61, CG7935, CIP-61, DIM-7, Dim-7, Dim7, DmRanBP7, Dmel\CG7935, Imp7, Imp7/8, Msk, S(ls)2, dim-7, dim7 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013388 44747 msk http://www.ncbi.nlm.nih.gov/gene/?term=44747 "Dmel_CG7935, 61, CG7935, CIP-61, DIM-7, Dim-7, Dim7, DmRanBP7, Dmel\CG7935, Imp7, Imp7/8, Msk, S(ls)2, dim-7, dim7 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013389 447559 rbpms2 http://www.ncbi.nlm.nih.gov/gene/?term=447559 hermes mRNA Xenopus laevis 23626739 Germ plasm Oocyte Microscopy "In addition to the Balbiani body, Hermes RNA is localised in germ plasm particles in the vegetal cortex of vitellogenic oocytes. " RLID00013390 447559 rbpms2 http://www.ncbi.nlm.nih.gov/gene/?term=447559 hermes mRNA Xenopus laevis 23626739 Mitochondrion Oocyte Microscopy "In addition to the Balbiani body, Hermes RNA is localised in germ plasm particles in the vegetal cortex of vitellogenic oocytes. " RLID00013391 447559 rbpms2 http://www.ncbi.nlm.nih.gov/gene/?term=447559 hermes mRNA Xenopus laevis 23626739 Vegetal Oocyte Microscopy "In addition to the Balbiani body, Hermes RNA is localised in germ plasm particles in the vegetal cortex of vitellogenic oocytes. " RLID00013392 447710 MGC81667 http://www.ncbi.nlm.nih.gov/gene/?term=447710 mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00013393 447760 srgap2 http://www.ncbi.nlm.nih.gov/gene/?term=447760 fnbp2 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00013394 4478 MSN http://www.ncbi.nlm.nih.gov/gene/?term=4478 HEL70 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013395 4478 MSN http://www.ncbi.nlm.nih.gov/gene/?term=4478 HEL70 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013396 44801 bsk http://www.ncbi.nlm.nih.gov/gene/?term=44801 "Dmel_CG5680, BSK, Bsk, CG5680, D-JNK, D-junk, DBSK/JNK, DJNK, DJNK/bsk, Dmel\CG5680, JNK, JNK/SAPK, Jnk, Junk, SAPKa, dJNK, jnk, pJNK " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013397 44811 E(bx) http://www.ncbi.nlm.nih.gov/gene/?term=44811 "Dmel_CG32346, CG10894, CG17135, CG32346, CG32478, CG7022, Dmel\CG32346, E(BX), E(Bx), Ebx, En-bx, NURF, NURF 215, NURF-215, NURF-301, NURF215, NURF301, NuRF301, Nurf 301, Nurf-215, Nurf301, dNURF, dNURF301, e(bx), l(3)122, l(3)ry122, nurf301, p215, p301 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013398 44811 E(bx) http://www.ncbi.nlm.nih.gov/gene/?term=44811 "Dmel_CG32346, CG10894, CG17135, CG32346, CG32478, CG7022, Dmel\CG32346, E(BX), E(Bx), Ebx, En-bx, NURF, NURF 215, NURF-215, NURF-301, NURF215, NURF301, NuRF301, Nurf 301, Nurf-215, Nurf301, dNURF, dNURF301, e(bx), l(3)122, l(3)ry122, nurf301, p215, p301 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013399 44817 for http://www.ncbi.nlm.nih.gov/gene/?term=44817 "Dmel_CG10033, 142251_at, BcDNA:GM08338, CG10033, DG2, Dg2, Dmel\CG10033, FOR/PKG, For, PKG, Pkg2, Pkg24A, anon-WO0140519.260, anon-WO02059370.47, dg2, l(2)06860 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013400 44817 for http://www.ncbi.nlm.nih.gov/gene/?term=44817 "Dmel_CG10033, 142251_at, BcDNA:GM08338, CG10033, DG2, Dg2, Dmel\CG10033, FOR/PKG, For, PKG, Pkg2, Pkg24A, anon-WO0140519.260, anon-WO02059370.47, dg2, l(2)06860 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013401 448274 xkrx http://www.ncbi.nlm.nih.gov/gene/?term=448274 "xk, xrg1 " mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00013402 4486 MST1R http://www.ncbi.nlm.nih.gov/gene/?term=4486 "CD136, CDw136, PTK8, RON " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013403 4486 MST1R http://www.ncbi.nlm.nih.gov/gene/?term=4486 "CD136, CDw136, PTK8, RON " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013404 44879 rhi http://www.ncbi.nlm.nih.gov/gene/?term=44879 "Dmel_CG10683, CG10683, Dmel\CG10683, HP1D, HP1d, RHI, Rhi, rno " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013405 4487 MSX1 http://www.ncbi.nlm.nih.gov/gene/?term=4487 "ECTD3, HOX7, HYD1, STHAG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013406 448831 FRG2 http://www.ncbi.nlm.nih.gov/gene/?term=448831 FRG2A mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013407 448831 FRG2 http://www.ncbi.nlm.nih.gov/gene/?term=448831 FRG2A mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013408 448850 Znhit3 http://www.ncbi.nlm.nih.gov/gene/?term=448850 "Myohd1, Trip3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00013409 449000 Zfp960 http://www.ncbi.nlm.nih.gov/gene/?term=449000 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00013410 4490 MT1B http://www.ncbi.nlm.nih.gov/gene/?term=4490 "MT1, MT1Q, MTP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013411 4493 MT1E http://www.ncbi.nlm.nih.gov/gene/?term=4493 "MT-1E, MT-IE, MT1, MTD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013412 4493 MT1E http://www.ncbi.nlm.nih.gov/gene/?term=4493 "MT-1E, MT-IE, MT1, MTD " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00013413 4493 MT1E http://www.ncbi.nlm.nih.gov/gene/?term=4493 "MT-1E, MT-IE, MT1, MTD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013414 4494 MT1F http://www.ncbi.nlm.nih.gov/gene/?term=4494 MT1 mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00013415 4494 MT1F http://www.ncbi.nlm.nih.gov/gene/?term=4494 MT1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013416 4495 MT1G http://www.ncbi.nlm.nih.gov/gene/?term=4495 "MT1, MT1K " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013417 4496 MT1H http://www.ncbi.nlm.nih.gov/gene/?term=4496 "MT-0, MT-1H, MT-IH, MT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013418 4501 MT1X http://www.ncbi.nlm.nih.gov/gene/?term=4501 "MT-1l, MT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013419 4502 MT2A http://www.ncbi.nlm.nih.gov/gene/?term=4502 MT2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013420 4502 MT2A http://www.ncbi.nlm.nih.gov/gene/?term=4502 MT2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013421 4502 MT2A http://www.ncbi.nlm.nih.gov/gene/?term=4502 MT2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013422 4507 MTAP http://www.ncbi.nlm.nih.gov/gene/?term=4507 "BDMF, DMSFH, DMSMFH, HEL-249, LGMBF, MSAP, c86fus " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013423 4507 MTAP http://www.ncbi.nlm.nih.gov/gene/?term=4507 "BDMF, DMSFH, DMSMFH, HEL-249, LGMBF, MSAP, c86fus " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013424 4507 MTAP http://www.ncbi.nlm.nih.gov/gene/?term=4507 "BDMF, DMSFH, DMSMFH, HEL-249, LGMBF, MSAP, c86fus " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013425 4508 MT-ATP6 http://www.ncbi.nlm.nih.gov/gene/?term=4508 "ATPase6, MTATP6, ATP6 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013426 4508 MT-ATP6 http://www.ncbi.nlm.nih.gov/gene/?term=4508 "ATPase6, MTATP6, ATP6 " mRNA Homo sapiens 21854988 Mitochondrion 143B cell Next-generation sequencing "Table S2, Relating to Figure 2, (Sheet A) Expression of annotated mRNA, tRNA and rRNA in 143B cells whole mitochondria and mitoplast preparations determined by RNA sequencing (reads per million per kb), and expression levels relative to total mitochondrial gene expression, and ratio of sense/antisense transcription relative to each gene indicated. Data are collected from Figure 2. " RLID00013427 4509 MT-ATP8 http://www.ncbi.nlm.nih.gov/gene/?term=4509 "ATPase8, MTATP8, ATP8 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013428 4509 MT-ATP8 http://www.ncbi.nlm.nih.gov/gene/?term=4509 "ATPase8, MTATP8, ATP8 " mRNA Homo sapiens 21854988 Mitochondrion 143B cell Next-generation sequencing "Table S2, Relating to Figure 2, (Sheet A) Expression of annotated mRNA, tRNA and rRNA in 143B cells whole mitochondria and mitoplast preparations determined by RNA sequencing (reads per million per kb), and expression levels relative to total mitochondrial gene expression, and ratio of sense/antisense transcription relative to each gene indicated. Data are collected from Figure 2. " RLID00013429 4511 MT-TC http://www.ncbi.nlm.nih.gov/gene/?term=4511 "MTTC, TRNC " tRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00013430 4512 MT-CO1 http://www.ncbi.nlm.nih.gov/gene/?term=4512 "COI, MTCO1, COX1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013431 4512 MT-CO1 http://www.ncbi.nlm.nih.gov/gene/?term=4512 "COI, MTCO1, COX1 " mRNA Homo sapiens 21854988 Mitochondrion 143B cell Next-generation sequencing "Table S2, Relating to Figure 2, (Sheet A) Expression of annotated mRNA, tRNA and rRNA in 143B cells whole mitochondria and mitoplast preparations determined by RNA sequencing (reads per million per kb), and expression levels relative to total mitochondrial gene expression, and ratio of sense/antisense transcription relative to each gene indicated. Data are collected from Figure 2. " RLID00013432 4513 MT-CO2 http://www.ncbi.nlm.nih.gov/gene/?term=4513 "COII, MTCO2, COX2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013433 4513 MT-CO2 http://www.ncbi.nlm.nih.gov/gene/?term=4513 "COII, MTCO2, COX2 " mRNA Homo sapiens 21854988 Mitochondrion 143B cell Next-generation sequencing "Table S2, Relating to Figure 2, (Sheet A) Expression of annotated mRNA, tRNA and rRNA in 143B cells whole mitochondria and mitoplast preparations determined by RNA sequencing (reads per million per kb), and expression levels relative to total mitochondrial gene expression, and ratio of sense/antisense transcription relative to each gene indicated. Data are collected from Figure 2. " RLID00013434 4514 MT-CO3 http://www.ncbi.nlm.nih.gov/gene/?term=4514 "COIII, MTCO3, COX3 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013435 4514 MT-CO3 http://www.ncbi.nlm.nih.gov/gene/?term=4514 "COIII, MTCO3, COX3 " mRNA Homo sapiens 21854988 Mitochondrion 143B cell Next-generation sequencing "Table S2, Relating to Figure 2, (Sheet A) Expression of annotated mRNA, tRNA and rRNA in 143B cells whole mitochondria and mitoplast preparations determined by RNA sequencing (reads per million per kb), and expression levels relative to total mitochondrial gene expression, and ratio of sense/antisense transcription relative to each gene indicated. Data are collected from Figure 2. " RLID00013436 4519 MT-CYB http://www.ncbi.nlm.nih.gov/gene/?term=4519 "MTCYB, CYTB " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013437 4519 MT-CYB http://www.ncbi.nlm.nih.gov/gene/?term=4519 "MTCYB, CYTB " mRNA Homo sapiens 21854988 Mitochondrion 143B cell Next-generation sequencing "Table S2, Relating to Figure 2, (Sheet A) Expression of annotated mRNA, tRNA and rRNA in 143B cells whole mitochondria and mitoplast preparations determined by RNA sequencing (reads per million per kb), and expression levels relative to total mitochondrial gene expression, and ratio of sense/antisense transcription relative to each gene indicated. Data are collected from Figure 2. " RLID00013438 4520 MTF1 http://www.ncbi.nlm.nih.gov/gene/?term=4520 "MTF-1, ZRF " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013439 4520 MTF1 http://www.ncbi.nlm.nih.gov/gene/?term=4520 "MTF-1, ZRF " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013440 4520 MTF1 http://www.ncbi.nlm.nih.gov/gene/?term=4520 "MTF-1, ZRF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013441 4521 NUDT1 http://www.ncbi.nlm.nih.gov/gene/?term=4521 MTH1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013442 4521 NUDT1 http://www.ncbi.nlm.nih.gov/gene/?term=4521 MTH1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013443 4522 MTHFD1 http://www.ncbi.nlm.nih.gov/gene/?term=4522 "MTHFC, MTHFD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013444 4522 MTHFD1 http://www.ncbi.nlm.nih.gov/gene/?term=4522 "MTHFC, MTHFD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013445 4522 MTHFD1 http://www.ncbi.nlm.nih.gov/gene/?term=4522 "MTHFC, MTHFD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013446 45247 VhaPPA1-1 http://www.ncbi.nlm.nih.gov/gene/?term=45247 "Dmel_CG7007, CG7007, Dmel\CG7007, VhaPPA1, vhaPPA1-1 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013447 45250 deltaCOP http://www.ncbi.nlm.nih.gov/gene/?term=45250 "Dmel_CG14813, 63B12S, ARCN1, Arch, CG14813, DM63B12S, Delta COP, DeltaCop, Dmel\CG14813, EG:63B12.10, ESTS:63B12S, anon-WO03040301.246, delta-Cop, deltaCop, l(1)G0051, l(1)G0301, l(1)G0450 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013448 45278 csw http://www.ncbi.nlm.nih.gov/gene/?term=45278 "Dmel_CG3954, 19-106, CG3954, CSW, Csw, Csw/Shp2, Dmel\CG3954, E(sev)1A, EG:BACN25G24.2, SHP-2, Shp-2, Shp2/csw, anon-WO03040301.207, anon-WO03040301.209, anon-WO03040301.219/SHP-2, l(1)2Db, l(1)2Dd, l(1)G0170, l(1)GA114, l(1)csw, csw " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013449 4528 MTIF2 http://www.ncbi.nlm.nih.gov/gene/?term=4528 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013450 4528 MTIF2 http://www.ncbi.nlm.nih.gov/gene/?term=4528 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013451 4528 MTIF2 http://www.ncbi.nlm.nih.gov/gene/?term=4528 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013452 4528 MTIF2 http://www.ncbi.nlm.nih.gov/gene/?term=4528 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013453 45307 fz http://www.ncbi.nlm.nih.gov/gene/?term=45307 "Dmel_CG17697, CG17697, CG3646, DFZ1, DFz, DFz1, Dfz, Dfz1, Dm Fz1, Dmel\CG17697, FZ, Frz, Fz, Fz1, dFz, frz1, fz[[1]], fz " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013454 4534 MTM1 http://www.ncbi.nlm.nih.gov/gene/?term=4534 "CNM, MTMX, XLMTM " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013455 4534 MTM1 http://www.ncbi.nlm.nih.gov/gene/?term=4534 "CNM, MTMX, XLMTM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013456 4535 MT-ND1 http://www.ncbi.nlm.nih.gov/gene/?term=4535 "MTND1, ND1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013457 4535 MT-ND1 http://www.ncbi.nlm.nih.gov/gene/?term=4535 "MTND1, ND1 " mRNA Homo sapiens 21854988 Mitochondrion 143B cell Next-generation sequencing "Table S2, Relating to Figure 2, (Sheet A) Expression of annotated mRNA, tRNA and rRNA in 143B cells whole mitochondria and mitoplast preparations determined by RNA sequencing (reads per million per kb), and expression levels relative to total mitochondrial gene expression, and ratio of sense/antisense transcription relative to each gene indicated. Data are collected from Figure 2. " RLID00013458 4536 MT-ND2 http://www.ncbi.nlm.nih.gov/gene/?term=4536 "MTND2, ND2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013459 4536 MT-ND2 http://www.ncbi.nlm.nih.gov/gene/?term=4536 "MTND2, ND2 " mRNA Homo sapiens 21854988 Mitochondrion 143B cell Next-generation sequencing "Table S2, Relating to Figure 2, (Sheet A) Expression of annotated mRNA, tRNA and rRNA in 143B cells whole mitochondria and mitoplast preparations determined by RNA sequencing (reads per million per kb), and expression levels relative to total mitochondrial gene expression, and ratio of sense/antisense transcription relative to each gene indicated. Data are collected from Figure 2. " RLID00013460 4537 MT-ND3 http://www.ncbi.nlm.nih.gov/gene/?term=4537 "MTND3, ND3 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013461 4537 MT-ND3 http://www.ncbi.nlm.nih.gov/gene/?term=4537 "MTND3, ND3 " mRNA Homo sapiens 21854988 Mitochondrion 143B cell Next-generation sequencing "Table S2, Relating to Figure 2, (Sheet A) Expression of annotated mRNA, tRNA and rRNA in 143B cells whole mitochondria and mitoplast preparations determined by RNA sequencing (reads per million per kb), and expression levels relative to total mitochondrial gene expression, and ratio of sense/antisense transcription relative to each gene indicated. Data are collected from Figure 2. " RLID00013462 4538 MT-ND4 http://www.ncbi.nlm.nih.gov/gene/?term=4538 "MTND4, ND4 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013463 4539 MT-ND4L http://www.ncbi.nlm.nih.gov/gene/?term=4539 "MTND4L, ND4L " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013464 4539 MT-ND4L http://www.ncbi.nlm.nih.gov/gene/?term=4539 "MTND4L, ND4L " mRNA Homo sapiens 21854988 Mitochondrion 143B cell Next-generation sequencing "Table S2, Relating to Figure 2, (Sheet A) Expression of annotated mRNA, tRNA and rRNA in 143B cells whole mitochondria and mitoplast preparations determined by RNA sequencing (reads per million per kb), and expression levels relative to total mitochondrial gene expression, and ratio of sense/antisense transcription relative to each gene indicated. Data are collected from Figure 2. " RLID00013465 4540 MT-ND5 http://www.ncbi.nlm.nih.gov/gene/?term=4540 "MTND5, ND5 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013466 4540 MT-ND5 http://www.ncbi.nlm.nih.gov/gene/?term=4540 "MTND5, ND5 " mRNA Homo sapiens 21854988 Mitochondrion 143B cell Next-generation sequencing "Table S2, Relating to Figure 2, (Sheet A) Expression of annotated mRNA, tRNA and rRNA in 143B cells whole mitochondria and mitoplast preparations determined by RNA sequencing (reads per million per kb), and expression levels relative to total mitochondrial gene expression, and ratio of sense/antisense transcription relative to each gene indicated. Data are collected from Figure 2. " RLID00013467 4541 MT-ND6 http://www.ncbi.nlm.nih.gov/gene/?term=4541 "MTND6, ND6 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013468 4541 MT-ND6 http://www.ncbi.nlm.nih.gov/gene/?term=4541 "MTND6, ND6 " mRNA Homo sapiens 21854988 Mitochondrion 143B cell Next-generation sequencing "Table S2, Relating to Figure 2, (Sheet A) Expression of annotated mRNA, tRNA and rRNA in 143B cells whole mitochondria and mitoplast preparations determined by RNA sequencing (reads per million per kb), and expression levels relative to total mitochondrial gene expression, and ratio of sense/antisense transcription relative to each gene indicated. Data are collected from Figure 2. " RLID00013469 45467 mtd http://www.ncbi.nlm.nih.gov/gene/?term=45467 "Dmel_CG32464, CG10196, CG10199, CG32464, Dmel\CG32464, L(3)82Fd, L82, anon-EST:Posey263, l(3)82FD, l(3)82Fd " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013470 45467 mtd http://www.ncbi.nlm.nih.gov/gene/?term=45467 "Dmel_CG32464, CG10196, CG10199, CG32464, Dmel\CG32464, L(3)82Fd, L82, anon-EST:Posey263, l(3)82FD, l(3)82Fd " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013471 4548 MTR http://www.ncbi.nlm.nih.gov/gene/?term=4548 "HMAG, MS, cblG " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013472 4548 MTR http://www.ncbi.nlm.nih.gov/gene/?term=4548 "HMAG, MS, cblG " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013473 4548 MTR http://www.ncbi.nlm.nih.gov/gene/?term=4548 "HMAG, MS, cblG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013474 4550 MT-RNR2 http://www.ncbi.nlm.nih.gov/gene/?term=4550 "MTRNR2, RNR2 " rRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00013475 45525 eIF-4E http://www.ncbi.nlm.nih.gov/gene/?term=45525 "Dmel_CG4035, 0260/09, 0587/11, 0589/11, 0919/12, 1004/13, 2, 7238, CBP, CG4035, CT13384, CT39424, CT39426, D-eIF4E, Dmel\CG4035, EIF4E, Eif4E, Eif4e, IF4E, dEif4e, deIF-4E, deIF4E, eIF 4E1, eIF-4E2, eIF-4EII, eIF-4e, eIF4E, eIF4E-1, eIF4E-1/2, eIF4E-2, eIF4E1, eIF4EI, eIF4e, eif-4E, eif-4e, eif4e, elF4E, l(3)07238, l(3)67Af, l(3)S025007, l(3)S026009, l(3)S058711, l(3)S091912, eIF-4E " mRNA Drosophila melanogaster 17923096 Posterior Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00013476 4552 MTRR http://www.ncbi.nlm.nih.gov/gene/?term=4552 "MSR, cblE " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013477 45683 milt http://www.ncbi.nlm.nih.gov/gene/?term=45683 "Dmel_CG43227, CG13777, CG31630, CG43227, Dmel\CG43227, Dmel_CG13777, Dmel_CG31630, anon-WO0153538.19, l(2)k04704 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013478 45683 milt http://www.ncbi.nlm.nih.gov/gene/?term=45683 "Dmel_CG43227, CG13777, CG31630, CG43227, Dmel\CG43227, Dmel_CG13777, Dmel_CG31630, anon-WO0153538.19, l(2)k04704 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013479 4569 MT-TM http://www.ncbi.nlm.nih.gov/gene/?term=4569 "MTTM, TRNM " tRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00013480 45706 Cyp4d14 http://www.ncbi.nlm.nih.gov/gene/?term=45706 "Dmel_CG3540, 4d14, CG3540, CYP4D14, Dmel\CG3540, EG:152A3.2 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013481 4574 MT-TS1 http://www.ncbi.nlm.nih.gov/gene/?term=4574 "MTTS1, TRNS1 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00013482 4575 MT-TS2 http://www.ncbi.nlm.nih.gov/gene/?term=4575 "MTTS2, TRNS2 " tRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00013483 45775 mei-P26 http://www.ncbi.nlm.nih.gov/gene/?term=45775 "Dmel_CG12218, AF145661, BcDNA:GH10646, CG12218, Dmel\CG12218, MEI-P26, Mei-P26, mei-p26 " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00013484 4577 MT-TV http://www.ncbi.nlm.nih.gov/gene/?term=4577 "MTTV, TRNV " tRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00013485 45780 Prosalpha1 http://www.ncbi.nlm.nih.gov/gene/?term=45780 "Dmel_CG18495, 18495, Alpha-1, CG18495, Dmel\CG18495, PSA6_DROME, Prosalpha6, alpha-1, alpha1, l(2)SH2 2342, l(2)SH2342, prosalpha1, prosalpha6 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013486 4580 MTX1 http://www.ncbi.nlm.nih.gov/gene/?term=4580 "MTX, MTXN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013487 4580 MTX1 http://www.ncbi.nlm.nih.gov/gene/?term=4580 "MTX, MTXN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013488 45827 bic http://www.ncbi.nlm.nih.gov/gene/?term=45827 "Dmel_CG3644, 107/12, 5A, BcDNA.GM05329, BcDNA:GM05329, Bic, Btf, CG3644, Dmel\CG3644, E(2)Bic, E(Bic), l(2)49Da, l(2)k10712, l(2)vr22, vr22 " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013489 45827 bic http://www.ncbi.nlm.nih.gov/gene/?term=45827 "Dmel_CG3644, 107/12, 5A, BcDNA.GM05329, BcDNA:GM05329, Bic, Btf, CG3644, Dmel\CG3644, E(2)Bic, E(Bic), l(2)49Da, l(2)k10712, l(2)vr22, vr22 " mRNA Drosophila melanogaster 25838129 Perinuclear Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013490 4582 MUC1 http://www.ncbi.nlm.nih.gov/gene/?term=4582 "ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013491 4583 MUC2 http://www.ncbi.nlm.nih.gov/gene/?term=4583 "MLP, MUC-2, SMUC " mRNA Homo sapiens 11724906 Endoplasmic reticulum Colorectal tissues In situ hybridization|Electron microscopy "Furthermore, electron microscopic in situ hybridization revealed that gold particles representing MUC2 mRNA are primarily localized over the RER. " RLID00013492 45840 cpo http://www.ncbi.nlm.nih.gov/gene/?term=45840 "Dmel_CG43738, 1824, 3603, 5339, 6015, BcDNA:AT31405, CG12349, CG18434, CG18435, CG31243, CG42457, CG43738, CPO, Cpo, Dmel\CG43738, Dmel_CG31243, Dmel_CG42457, E(sda)N, Line N, ORE-17, cg18435, l(3)01432, l(3)6015, l(3)j4A1, l(3)j4D4, l(3)j7E2, l(3)j9B3, l(3)rJ553, l(3)s2336 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013493 4588 MUC6 http://www.ncbi.nlm.nih.gov/gene/?term=4588 MUC-6 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013494 4591 TRIM37 http://www.ncbi.nlm.nih.gov/gene/?term=4591 "MUL, POB1, TEF3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013495 45931 spir http://www.ncbi.nlm.nih.gov/gene/?term=45931 "Dmel_CG10076, 38C.34, 38C.37, CG10076, CG18621, Dmel\CG10076, NP2788, Spir, Spire, l(2)08327, p150-Spir, p150Spir " mRNA Drosophila melanogaster 17923096 Posterior Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00013496 4594 MUT http://www.ncbi.nlm.nih.gov/gene/?term=4594 MCM mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013497 4595 MUTYH http://www.ncbi.nlm.nih.gov/gene/?term=4595 MYH mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013498 45960 aly http://www.ncbi.nlm.nih.gov/gene/?term=45960 "Dmel_CG2075, 143450_at, Aly, CG2075, Dmel\CG2075, ms(3)2, ms(3)ry2 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013499 45969 gwl http://www.ncbi.nlm.nih.gov/gene/?term=45969 "Dmel_CG7719, 1J, CG7719, CG7719-related, CT23435, Dmel\CG7719, EP0515, Gwl, Pk91C, Pk?2, anon-WO2004063362.73, scant " mRNA Drosophila melanogaster 17923096 Posterior Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00013500 45973 fs(1)N http://www.ncbi.nlm.nih.gov/gene/?term=45973 "Dmel_CG11411, 371, 8D8.1, CG11411, Dmel\CG11411, EG:8D8.1, Fs(1)N, Nas, fs(1)A371, fs(1)K1540, fs(1)M6as, fs(1)Nasrat, fs(1)[nas], nas, fs(1)N " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013501 45973 fs(1)N http://www.ncbi.nlm.nih.gov/gene/?term=45973 "Dmel_CG11411, 371, 8D8.1, CG11411, Dmel\CG11411, EG:8D8.1, Fs(1)N, Nas, fs(1)A371, fs(1)K1540, fs(1)M6as, fs(1)Nasrat, fs(1)[nas], nas, fs(1)N " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013502 45973 fs(1)N http://www.ncbi.nlm.nih.gov/gene/?term=45973 "Dmel_CG11411, 371, 8D8.1, CG11411, Dmel\CG11411, EG:8D8.1, Fs(1)N, Nas, fs(1)A371, fs(1)K1540, fs(1)M6as, fs(1)Nasrat, fs(1)[nas], nas, fs(1)N " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013503 4597 MVD http://www.ncbi.nlm.nih.gov/gene/?term=4597 "FP17780, MDDase, MPD, POROK7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013504 4597 MVD http://www.ncbi.nlm.nih.gov/gene/?term=4597 "FP17780, MDDase, MPD, POROK7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013505 4598 MVK http://www.ncbi.nlm.nih.gov/gene/?term=4598 "LRBP, MK, MVLK, POROK3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013506 4598 MVK http://www.ncbi.nlm.nih.gov/gene/?term=4598 "LRBP, MK, MVLK, POROK3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013507 4601 MXI1 http://www.ncbi.nlm.nih.gov/gene/?term=4601 "MAD2, MXD2, MXI, bHLHc11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013508 4602 MYB http://www.ncbi.nlm.nih.gov/gene/?term=4602 "Cmyb, c-myb, c-myb_CDS, efg " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013509 4602 MYB http://www.ncbi.nlm.nih.gov/gene/?term=4602 "Cmyb, c-myb, c-myb_CDS, efg " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013510 4605 MYBL2 http://www.ncbi.nlm.nih.gov/gene/?term=4605 "B-MYB, BMYB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013511 46078 vlc http://www.ncbi.nlm.nih.gov/gene/?term=46078 "Dmel_CG8390, CG8390, Dmel\CG8390, X, anon-41Fa, anon-WO0118547.98, l(2)07022 " mRNA Drosophila melanogaster 25838129 Cell cortex Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013512 4609 MYC http://www.ncbi.nlm.nih.gov/gene/?term=4609 "MRTLC, bHLHe39, c-Myc, MYC " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013513 4609 MYC http://www.ncbi.nlm.nih.gov/gene/?term=4609 "MRTLC, bHLHe39, c-Myc, MYC " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013514 4609 MYC http://www.ncbi.nlm.nih.gov/gene/?term=4609 "MRTLC, bHLHe39, c-Myc, MYC " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013515 4609 MYC http://www.ncbi.nlm.nih.gov/gene/?term=4609 "MRTL, MYCC, bHLHe39, c-Myc " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013516 4610 MYCL http://www.ncbi.nlm.nih.gov/gene/?term=4610 "L-Myc, LMYC1, bHLHe38, MYCL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013517 4610 MYCL http://www.ncbi.nlm.nih.gov/gene/?term=4610 "L-Myc, LMYC, MYCL1, bHLHe38 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013518 4613 MYCN http://www.ncbi.nlm.nih.gov/gene/?term=4613 "MODED, N-myc, NMYC, ODED, bHLHe37 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013519 4615 MYD88 http://www.ncbi.nlm.nih.gov/gene/?term=4615 MYD88D mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013520 4615 MYD88 http://www.ncbi.nlm.nih.gov/gene/?term=4615 MYD88D mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013521 4619 MYH1 http://www.ncbi.nlm.nih.gov/gene/?term=4619 "HEL71, MYHSA1, MYHa, MyHC-2X/D, MyHC-2x " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013522 4627 MYH9 http://www.ncbi.nlm.nih.gov/gene/?term=4627 "BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013523 4627 MYH9 http://www.ncbi.nlm.nih.gov/gene/?term=4627 "BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013524 4627 MYH9 http://www.ncbi.nlm.nih.gov/gene/?term=4627 "BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013525 4628 MYH10 http://www.ncbi.nlm.nih.gov/gene/?term=4628 "NMMHC-IIB, NMMHCB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013526 4628 MYH10 http://www.ncbi.nlm.nih.gov/gene/?term=4628 "NMMHC-IIB, NMMHCB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013527 4629 MYH11 http://www.ncbi.nlm.nih.gov/gene/?term=4629 "AAT4, FAA4, SMHC, SMMHC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013528 462 SERPINC1 http://www.ncbi.nlm.nih.gov/gene/?term=462 "AT3, AT3D, ATIII, THPH7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013529 4632 MYL1 http://www.ncbi.nlm.nih.gov/gene/?term=4632 "MLC1F, MLC3F " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013530 4635 MYL4 http://www.ncbi.nlm.nih.gov/gene/?term=4635 "ALC1, AMLC, GT1, PRO1957 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013531 4637 MYL6 http://www.ncbi.nlm.nih.gov/gene/?term=4637 "ESMLC, LC17, LC17-GI, LC17-NM, LC17A, LC17B, MLC-3, MLC1SM, MLC3NM, MLC3SM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013532 4637 MYL6 http://www.ncbi.nlm.nih.gov/gene/?term=4637 "ESMLC, LC17, LC17-GI, LC17-NM, LC17A, LC17B, MLC-3, MLC1SM, MLC3NM, MLC3SM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013533 4638 MYLK http://www.ncbi.nlm.nih.gov/gene/?term=4638 "AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013534 4641 MYO1C http://www.ncbi.nlm.nih.gov/gene/?term=4641 "MMI-beta, MMIb, NMI, myr2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013535 4641 MYO1C http://www.ncbi.nlm.nih.gov/gene/?term=4641 "MMI-beta, MMIb, NMI, myr2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013536 4643 MYO1E http://www.ncbi.nlm.nih.gov/gene/?term=4643 "FSGS6, HuncM-IC, MYO1C " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013537 4645 MYO5B http://www.ncbi.nlm.nih.gov/gene/?term=4645 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013538 4645 MYO5B http://www.ncbi.nlm.nih.gov/gene/?term=4645 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013539 4646 MYO6 http://www.ncbi.nlm.nih.gov/gene/?term=4646 "DFNA22, DFNB37 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013540 4646 MYO6 http://www.ncbi.nlm.nih.gov/gene/?term=4646 "DFNA22, DFNB37 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013541 4647 MYO7A http://www.ncbi.nlm.nih.gov/gene/?term=4647 "DFNA11, DFNB2, MYOVIIA, MYU7A, NSRD2, USH1B " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013542 4649 MYO9A http://www.ncbi.nlm.nih.gov/gene/?term=4649 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013543 4650 MYO9B http://www.ncbi.nlm.nih.gov/gene/?term=4650 "CELIAC4, MYR5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013544 4650 MYO9B http://www.ncbi.nlm.nih.gov/gene/?term=4650 "CELIAC4, MYR5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013545 4651 MYO10 http://www.ncbi.nlm.nih.gov/gene/?term=4651 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013546 4651 MYO10 http://www.ncbi.nlm.nih.gov/gene/?term=4651 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013547 4651 MYO10 http://www.ncbi.nlm.nih.gov/gene/?term=4651 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013548 4651 MYO10 http://www.ncbi.nlm.nih.gov/gene/?term=4651 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013549 4659 PPP1R12A http://www.ncbi.nlm.nih.gov/gene/?term=4659 "M130, MBS, MYPT1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013550 4659 PPP1R12A http://www.ncbi.nlm.nih.gov/gene/?term=4659 "M130, MBS, MYPT1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013551 4659 PPP1R12A http://www.ncbi.nlm.nih.gov/gene/?term=4659 "M130, MBS, MYPT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013552 4660 PPP1R12B http://www.ncbi.nlm.nih.gov/gene/?term=4660 "MYPT2, PP1bp55 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013553 4660 PPP1R12B http://www.ncbi.nlm.nih.gov/gene/?term=4660 "MYPT2, PP1bp55 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013554 4660 PPP1R12B http://www.ncbi.nlm.nih.gov/gene/?term=4660 "MYPT2, PP1bp55 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013555 4664 NAB1 http://www.ncbi.nlm.nih.gov/gene/?term=4664 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013556 4665 NAB2 http://www.ncbi.nlm.nih.gov/gene/?term=4665 MADER mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013557 4666 NACA http://www.ncbi.nlm.nih.gov/gene/?term=4666 "HSD48, NAC-alpha1, skNAC, NACA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013558 4666 NACA http://www.ncbi.nlm.nih.gov/gene/?term=4666 "HSD48, NAC-alpha1, skNAC, NACA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013559 4666 NACA http://www.ncbi.nlm.nih.gov/gene/?term=4666 "HSD48, NAC-alpha, NACA1, skNAC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013560 4668 NAGA http://www.ncbi.nlm.nih.gov/gene/?term=4668 "D22S674, GALB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013561 4668 NAGA http://www.ncbi.nlm.nih.gov/gene/?term=4668 "D22S674, GALB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013562 4668 NAGA http://www.ncbi.nlm.nih.gov/gene/?term=4668 "D22S674, GALB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013563 4669 NAGLU http://www.ncbi.nlm.nih.gov/gene/?term=4669 "CMT2V, MPS-IIIB, MPS3B, NAG, UFHSD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013564 466 ATF1 http://www.ncbi.nlm.nih.gov/gene/?term=466 "EWS-ATF1, FUS/ATF-1, TREB36 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013565 4670 HNRNPM http://www.ncbi.nlm.nih.gov/gene/?term=4670 "CEAR4, HNRPM, HNRPM4, HTGR1, NAGR1, hnRNP M, HNRNPM " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013566 4670 HNRNPM http://www.ncbi.nlm.nih.gov/gene/?term=4670 "CEAR, HNRNPM4, HNRPM, HNRPM4, HTGR1, NAGR1, hnRNP M " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013567 46719 dlt http://www.ncbi.nlm.nih.gov/gene/?term=46719 "Dmel_CG32315, CG1977, CG32315, DLT, Dlt, Dmel\CG32315, Van, dre1, l(3)04276, l(3)62Ba, l(3)dre1 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013568 46719 dlt http://www.ncbi.nlm.nih.gov/gene/?term=46719 "Dmel_CG32315, CG1977, CG32315, DLT, Dlt, Dmel\CG32315, Van, dre1, l(3)04276, l(3)62Ba, l(3)dre1 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013569 4673 NAP1L1 http://www.ncbi.nlm.nih.gov/gene/?term=4673 "NAP1, NAP1L, NRP " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013570 4673 NAP1L1 http://www.ncbi.nlm.nih.gov/gene/?term=4673 "NAP1, NAP1L, NRP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013571 4674 NAP1L2 http://www.ncbi.nlm.nih.gov/gene/?term=4674 BPX mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013572 4676 NAP1L4 http://www.ncbi.nlm.nih.gov/gene/?term=4676 "NAP1L4b, NAP2, NAP2L, hNAP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013573 4676 NAP1L4 http://www.ncbi.nlm.nih.gov/gene/?term=4676 "NAP1L4b, NAP2, NAP2L, hNAP2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013574 4676 NAP1L4 http://www.ncbi.nlm.nih.gov/gene/?term=4676 "NAP1L4b, NAP2, NAP2L, hNAP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013575 4677 NARS http://www.ncbi.nlm.nih.gov/gene/?term=4677 "ASNRS1, NARS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013576 4678 NASP http://www.ncbi.nlm.nih.gov/gene/?term=4678 "FLB7527, HMDRA1, PRO1999 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013577 4678 NASP http://www.ncbi.nlm.nih.gov/gene/?term=4678 "FLB7527, HMDRA1, PRO1999 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013578 4678 NASP http://www.ncbi.nlm.nih.gov/gene/?term=4678 "FLB7527, HMDRA1, PRO1999 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013579 467 ATF3 http://www.ncbi.nlm.nih.gov/gene/?term=467 mRNA Homo sapiens 16109718 Cytoplasm HepG2 cell qRT-PCR "In vivo HuR and AUF1 binding to the ATF3 mRNA in the cytoplasm. For the data shown in B and C, the immunoprecipitated RNA was analyzed by qPCR to quantify the relative amount of HuR or AUF1 protein bound to the ATF3 mRNA during incubation in complete MEM and MEM lacking histidine (MEM-His). " RLID00013580 467 ATF3 http://www.ncbi.nlm.nih.gov/gene/?term=467 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013581 4680 CEACAM6 http://www.ncbi.nlm.nih.gov/gene/?term=4680 "CD66c, CEAL, NCA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013582 4681 NBL1 http://www.ncbi.nlm.nih.gov/gene/?term=4681 "D1S1733E, DAN, DAND1, NB, NO3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013583 4681 NBL1 http://www.ncbi.nlm.nih.gov/gene/?term=4681 "D1S1733E, DAN, DAND1, NB, NO3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013584 4682 NUBP1 http://www.ncbi.nlm.nih.gov/gene/?term=4682 "NBP, NBP1, NBP35 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013585 4682 NUBP1 http://www.ncbi.nlm.nih.gov/gene/?term=4682 "NBP, NBP1, NBP35 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013586 4683 NBN http://www.ncbi.nlm.nih.gov/gene/?term=4683 "AT-V1, AT-V2, ATV, NBS, NBS1, P95 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013587 4683 NBN http://www.ncbi.nlm.nih.gov/gene/?term=4683 "AT-V1, AT-V2, ATV, NBS, NBS1, P95 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013588 4684 NCAM1 http://www.ncbi.nlm.nih.gov/gene/?term=4684 "CD56, MSK39, NCAM " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013589 4685 NCAM2 http://www.ncbi.nlm.nih.gov/gene/?term=4685 NCAM21 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013590 4686 NCBP1 http://www.ncbi.nlm.nih.gov/gene/?term=4686 "CBP80, NCBP, Sto1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013591 4686 NCBP1 http://www.ncbi.nlm.nih.gov/gene/?term=4686 "CBP80, NCBP, Sto1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013592 468 ATF4 http://www.ncbi.nlm.nih.gov/gene/?term=468 "CREB-2, CREB2, TAXREB67, TXREB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013593 468 ATF4 http://www.ncbi.nlm.nih.gov/gene/?term=468 "CREB-2, CREB2, TAXREB67, TXREB " mRNA Homo sapiens 26239904 Endoplasmic reticulum Kidney RT-PCR "Although the underlying mechanisms were not known, this increased association might be attributed to the diffused localization of the 32-447aa mutant, thereby allowing the mutant to associate not only with ATF4 mRNAs on the ER but also with the mRNAs in cytoplasm. (D-F) The abundance of ATF4 or β-actin mRNA in the subpolysome or polysome pool. " RLID00013594 468 ATF4 http://www.ncbi.nlm.nih.gov/gene/?term=468 "CREB-2, CREB2, TAXREB67, TXREB " mRNA Homo sapiens 26239904 Cytoplasm Kidney RT-PCR "Although the underlying mechanisms were not known, this increased association might be attributed to the diffused localization of the 32-447aa mutant, thereby allowing the mutant to associate not only with ATF4 mRNAs on the ER but also with the mRNAs in cytoplasm. (D-F) The abundance of ATF4 or β-actin mRNA in the subpolysome or polysome pool. " RLID00013595 468 ATF4 http://www.ncbi.nlm.nih.gov/gene/?term=468 "CREB-2, CREB2, TAXREB67, TXREB " mRNA Homo sapiens 26239904 Ribosome Kidney RT-PCR "Although the underlying mechanisms were not known, this increased association might be attributed to the diffused localization of the 32-447aa mutant, thereby allowing the mutant to associate not only with ATF4 mRNAs on the ER but also with the mRNAs in cytoplasm. (D-F) The abundance of ATF4 or β-actin mRNA in the subpolysome or polysome pool. " RLID00013596 468 ATF4 http://www.ncbi.nlm.nih.gov/gene/?term=468 "CREB-2, CREB2, TAXREB67, TXREB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013597 468 ATF4 http://www.ncbi.nlm.nih.gov/gene/?term=468 "CREB-2, CREB2, TAXREB67, TXREB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013598 4690 NCK1 http://www.ncbi.nlm.nih.gov/gene/?term=4690 "NCK, NCKalpha, nck-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013599 4690 NCK1 http://www.ncbi.nlm.nih.gov/gene/?term=4690 "NCK, NCKalpha, nck-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013600 4690 NCK1 http://www.ncbi.nlm.nih.gov/gene/?term=4690 "NCK, NCKalpha, nck-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013601 4691 NCL http://www.ncbi.nlm.nih.gov/gene/?term=4691 C23 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013602 4691 NCL http://www.ncbi.nlm.nih.gov/gene/?term=4691 C23 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013603 4692 NDN http://www.ncbi.nlm.nih.gov/gene/?term=4692 "HsT16328, PWCR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013604 4693 NDP http://www.ncbi.nlm.nih.gov/gene/?term=4693 "EVR2, FEVR, ND " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013605 4694 NDUFA1 http://www.ncbi.nlm.nih.gov/gene/?term=4694 "CI-MWFE, MWFE, ZNF183 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013606 4694 NDUFA1 http://www.ncbi.nlm.nih.gov/gene/?term=4694 "CI-MWFE, MWFE, ZNF183 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013607 4695 NDUFA2 http://www.ncbi.nlm.nih.gov/gene/?term=4695 "B8, CD14, CIB8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013608 4696 NDUFA3 http://www.ncbi.nlm.nih.gov/gene/?term=4696 "B9, CI-B9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013609 4696 NDUFA3 http://www.ncbi.nlm.nih.gov/gene/?term=4696 "B9, CI-B9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013610 4697 NDUFA4 http://www.ncbi.nlm.nih.gov/gene/?term=4697 "CI-9k, CI-MLRQ, MLRQ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013611 4697 NDUFA4 http://www.ncbi.nlm.nih.gov/gene/?term=4697 "CI-9k, CI-MLRQ, MLRQ " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013612 4698 NDUFA5 http://www.ncbi.nlm.nih.gov/gene/?term=4698 "B13, CI-13KD-B, CI-13kB, NUFM, UQOR13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013613 4698 NDUFA5 http://www.ncbi.nlm.nih.gov/gene/?term=4698 "B13, CI-13KD-B, CI-13kB, NUFM, UQOR13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013614 4700 NDUFA6 http://www.ncbi.nlm.nih.gov/gene/?term=4700 "B14, CI-B14, LYRM6, NADHB14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013615 4701 NDUFA7 http://www.ncbi.nlm.nih.gov/gene/?term=4701 B14.5a mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013616 4702 NDUFA8 http://www.ncbi.nlm.nih.gov/gene/?term=4702 "CI-19KD, CI-PGIV, PGIV " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013617 4703 NEB http://www.ncbi.nlm.nih.gov/gene/?term=4703 "NEB177D, NEM2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013618 4704 NDUFA9 http://www.ncbi.nlm.nih.gov/gene/?term=4704 "CC6, CI-39k, CI39k, NDUFS2L, SDR22E1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013619 4704 NDUFA9 http://www.ncbi.nlm.nih.gov/gene/?term=4704 "CC6, CI-39k, CI39k, NDUFS2L, SDR22E1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013620 4705 NDUFA10 http://www.ncbi.nlm.nih.gov/gene/?term=4705 "CI-42KD, CI-42k " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013621 4705 NDUFA10 http://www.ncbi.nlm.nih.gov/gene/?term=4705 "CI-42KD, CI-42k " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013622 4706 NDUFAB1 http://www.ncbi.nlm.nih.gov/gene/?term=4706 "ACP, FASN2A, SDAP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013623 4706 NDUFAB1 http://www.ncbi.nlm.nih.gov/gene/?term=4706 "ACP, FASN2A, SDAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013624 4707 NDUFB1 http://www.ncbi.nlm.nih.gov/gene/?term=4707 "CI-MNLL, CI-SGDH, MNLL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013625 4707 NDUFB1 http://www.ncbi.nlm.nih.gov/gene/?term=4707 "CI-MNLL, CI-SGDH, MNLL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013626 4708 NDUFB2 http://www.ncbi.nlm.nih.gov/gene/?term=4708 "AGGG, CI-AGGG " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013627 4708 NDUFB2 http://www.ncbi.nlm.nih.gov/gene/?term=4708 "AGGG, CI-AGGG " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013628 4708 NDUFB2 http://www.ncbi.nlm.nih.gov/gene/?term=4708 "AGGG, CI-AGGG " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013629 4708 NDUFB2 http://www.ncbi.nlm.nih.gov/gene/?term=4708 "AGGG, CI-AGGG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013630 4709 NDUFB3 http://www.ncbi.nlm.nih.gov/gene/?term=4709 "B12, CI-B12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013631 4710 NDUFB4 http://www.ncbi.nlm.nih.gov/gene/?term=4710 "B15, CI-B15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013632 4711 NDUFB5 http://www.ncbi.nlm.nih.gov/gene/?term=4711 "CISGDH, SGDH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013633 4711 NDUFB5 http://www.ncbi.nlm.nih.gov/gene/?term=4711 "CISGDH, SGDH " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013634 4712 NDUFB6 http://www.ncbi.nlm.nih.gov/gene/?term=4712 "B17, CI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013635 4713 NDUFB7 http://www.ncbi.nlm.nih.gov/gene/?term=4713 "B18, CI-B18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013636 4713 NDUFB7 http://www.ncbi.nlm.nih.gov/gene/?term=4713 "B18, CI-B18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013637 4714 NDUFB8 http://www.ncbi.nlm.nih.gov/gene/?term=4714 "ASHI, CI-ASHI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013638 4715 NDUFB9 http://www.ncbi.nlm.nih.gov/gene/?term=4715 "B22, CI-B22, LYRM3, UQOR22 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013639 4716 NDUFB10 http://www.ncbi.nlm.nih.gov/gene/?term=4716 PDSW mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013640 4716 NDUFB10 http://www.ncbi.nlm.nih.gov/gene/?term=4716 PDSW mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013641 4717 NDUFC1 http://www.ncbi.nlm.nih.gov/gene/?term=4717 KFYI mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013642 4717 NDUFC1 http://www.ncbi.nlm.nih.gov/gene/?term=4717 KFYI mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013643 4718 NDUFC2 http://www.ncbi.nlm.nih.gov/gene/?term=4718 "B14.5b, CI-B14.5b, HLC-1, NADHDH2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013644 4718 NDUFC2 http://www.ncbi.nlm.nih.gov/gene/?term=4718 "B14.5b, CI-B14.5b, HLC-1, NADHDH2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013645 4718 NDUFC2 http://www.ncbi.nlm.nih.gov/gene/?term=4718 "B14.5b, CI-B14.5b, HLC-1, NADHDH2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013646 4719 NDUFS1 http://www.ncbi.nlm.nih.gov/gene/?term=4719 "CI-75Kd, CI-75k, PRO1304 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013647 4719 NDUFS1 http://www.ncbi.nlm.nih.gov/gene/?term=4719 "CI-75Kd, CI-75k, PRO1304 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013648 4720 NDUFS2 http://www.ncbi.nlm.nih.gov/gene/?term=4720 CI-49 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013649 47220 Fur1 http://www.ncbi.nlm.nih.gov/gene/?term=47220 "Dmel_CG10772, CG10772, Dfur1, Dfurin1, Dmel\CG10772, Furin, Furl, Klip1, dFur1, dFurin 1, dKLIP-1, fur-1, fur1, fur[1], furin, l(3)rL205 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013650 47220 Fur1 http://www.ncbi.nlm.nih.gov/gene/?term=47220 "Dmel_CG10772, CG10772, Dfur1, Dfurin1, Dmel\CG10772, Furin, Furl, Klip1, dFur1, dFurin 1, dKLIP-1, fur-1, fur1, fur[1], furin, l(3)rL205 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013651 4722 NDUFS3 http://www.ncbi.nlm.nih.gov/gene/?term=4722 CI-30 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013652 4723 NDUFV1 http://www.ncbi.nlm.nih.gov/gene/?term=4723 "CI-51K, CI51KD, UQOR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013653 4724 NDUFS4 http://www.ncbi.nlm.nih.gov/gene/?term=4724 "AQDQ, CI-18, CI-18 kDa, CI-AQDQ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013654 4725 NDUFS5 http://www.ncbi.nlm.nih.gov/gene/?term=4725 "CI-15k, CI15K " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013655 4725 NDUFS5 http://www.ncbi.nlm.nih.gov/gene/?term=4725 "CI-15k, CI15K " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013656 4726 NDUFS6 http://www.ncbi.nlm.nih.gov/gene/?term=4726 "CI-13kA, CI-13kD-A, CI13KDA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013657 4728 NDUFS8 http://www.ncbi.nlm.nih.gov/gene/?term=4728 "CI-23k, CI23KD, TYKY " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013658 4728 NDUFS8 http://www.ncbi.nlm.nih.gov/gene/?term=4728 "CI-23k, CI23KD, TYKY " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013659 4729 NDUFV2 http://www.ncbi.nlm.nih.gov/gene/?term=4729 CI-24k mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013660 472 ATM http://www.ncbi.nlm.nih.gov/gene/?term=472 "AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013661 472 ATM http://www.ncbi.nlm.nih.gov/gene/?term=472 "AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013662 472 ATM http://www.ncbi.nlm.nih.gov/gene/?term=472 "AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013663 4731 NDUFV3 http://www.ncbi.nlm.nih.gov/gene/?term=4731 "CI-10k, CI-9KD " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013664 4731 NDUFV3 http://www.ncbi.nlm.nih.gov/gene/?term=4731 "CI-10k, CI-9KD " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013665 4731 NDUFV3 http://www.ncbi.nlm.nih.gov/gene/?term=4731 "CI-10k, CI-9KD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013666 4733 DRG1 http://www.ncbi.nlm.nih.gov/gene/?term=4733 NEDD3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013667 4733 DRG1 http://www.ncbi.nlm.nih.gov/gene/?term=4733 NEDD3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013668 4733 DRG1 http://www.ncbi.nlm.nih.gov/gene/?term=4733 NEDD3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013669 4734 NEDD4 http://www.ncbi.nlm.nih.gov/gene/?term=4734 "NEDD4-1, RPF1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013670 4734 NEDD4 http://www.ncbi.nlm.nih.gov/gene/?term=4734 "NEDD4-1, RPF1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013671 4734 NEDD4 http://www.ncbi.nlm.nih.gov/gene/?term=4734 "NEDD4-1, RPF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013672 4735 SEPT2 http://www.ncbi.nlm.nih.gov/gene/?term=4735 "DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013673 4736 RPL10A http://www.ncbi.nlm.nih.gov/gene/?term=4736 "CSA19, Csa-19, L10A, NEDD6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013674 4738 NEDD8 http://www.ncbi.nlm.nih.gov/gene/?term=4738 NEDD-8 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013675 4738 NEDD8 http://www.ncbi.nlm.nih.gov/gene/?term=4738 NEDD-8 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013676 47399 Reph http://www.ncbi.nlm.nih.gov/gene/?term=47399 "Dmel_CG3920, CG3920, Dmel\CG3920, l(2)k16918, reph " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013677 473 RERE http://www.ncbi.nlm.nih.gov/gene/?term=473 "ARG, ARP, ATN1L, DNB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013678 474526 PWP1 http://www.ncbi.nlm.nih.gov/gene/?term=474526 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013679 474536 TXNRD1 http://www.ncbi.nlm.nih.gov/gene/?term=474536 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013680 474568 ANKRD39 http://www.ncbi.nlm.nih.gov/gene/?term=474568 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013681 474595 ACYP2 http://www.ncbi.nlm.nih.gov/gene/?term=474595 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013682 474624 GFPT1 http://www.ncbi.nlm.nih.gov/gene/?term=474624 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013683 474625 AAK1 http://www.ncbi.nlm.nih.gov/gene/?term=474625 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013684 474635 COMMD10 http://www.ncbi.nlm.nih.gov/gene/?term=474635 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013685 474844 CSNK2B http://www.ncbi.nlm.nih.gov/gene/?term=474844 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013686 474884 RPL10A http://www.ncbi.nlm.nih.gov/gene/?term=474884 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013687 474891 PPIL1 http://www.ncbi.nlm.nih.gov/gene/?term=474891 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013688 474977 SH3BGRL2 http://www.ncbi.nlm.nih.gov/gene/?term=474977 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013689 475041 PDCD2 http://www.ncbi.nlm.nih.gov/gene/?term=475041 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013690 475043 HRSP12 http://www.ncbi.nlm.nih.gov/gene/?term=475043 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013691 475057 ODF1 http://www.ncbi.nlm.nih.gov/gene/?term=475057 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013692 4750 NEK1 http://www.ncbi.nlm.nih.gov/gene/?term=4750 "NY-REN-55, SRPS2, SRPS2A, SRTD6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013693 475148 MSI2 http://www.ncbi.nlm.nih.gov/gene/?term=475148 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013694 475158 CENPC http://www.ncbi.nlm.nih.gov/gene/?term=475158 CENPC1 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013695 4751 NEK2 http://www.ncbi.nlm.nih.gov/gene/?term=4751 "HsPK21A, NLK1, PPP1R111, RP67, NEK2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013696 4751 NEK2 http://www.ncbi.nlm.nih.gov/gene/?term=4751 "HsPK21A, NLK1, PPP1R111, RP67, NEK2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013697 4751 NEK2 http://www.ncbi.nlm.nih.gov/gene/?term=4751 "HsPK21, NEK2A, NLK1, PPP1R111, RP67 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013698 475231 BET1 http://www.ncbi.nlm.nih.gov/gene/?term=475231 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013699 475261 SNX10 http://www.ncbi.nlm.nih.gov/gene/?term=475261 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013700 475289 ZNF277 http://www.ncbi.nlm.nih.gov/gene/?term=475289 ZNF277P mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013701 4752 NEK3 http://www.ncbi.nlm.nih.gov/gene/?term=4752 HSPK36 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013702 475333 MRPS15 http://www.ncbi.nlm.nih.gov/gene/?term=475333 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013703 475346 VPS35 http://www.ncbi.nlm.nih.gov/gene/?term=475346 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013704 475358 RNF11 http://www.ncbi.nlm.nih.gov/gene/?term=475358 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013705 475385 DMAP1 http://www.ncbi.nlm.nih.gov/gene/?term=475385 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013706 475403 TOX4 http://www.ncbi.nlm.nih.gov/gene/?term=475403 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013707 475450 NFYB http://www.ncbi.nlm.nih.gov/gene/?term=475450 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013708 475453 ANAPC10 http://www.ncbi.nlm.nih.gov/gene/?term=475453 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013709 475455 OTUD4 http://www.ncbi.nlm.nih.gov/gene/?term=475455 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013710 475467 ARFIP1 http://www.ncbi.nlm.nih.gov/gene/?term=475467 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013711 475524 SSBP1 http://www.ncbi.nlm.nih.gov/gene/?term=475524 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013712 475566 FNTA http://www.ncbi.nlm.nih.gov/gene/?term=475566 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013713 475590 EIF4EBP1 http://www.ncbi.nlm.nih.gov/gene/?term=475590 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013714 475675 SMC6 http://www.ncbi.nlm.nih.gov/gene/?term=475675 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013715 4756 NEO1 http://www.ncbi.nlm.nih.gov/gene/?term=4756 "IGDCC2, NGN, NTN1R2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013716 4756 NEO1 http://www.ncbi.nlm.nih.gov/gene/?term=4756 "IGDCC2, NGN, NTN1R2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013717 475733 MORN2 http://www.ncbi.nlm.nih.gov/gene/?term=475733 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013718 475746 MRPS5 http://www.ncbi.nlm.nih.gov/gene/?term=475746 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013719 475816 SEC22B http://www.ncbi.nlm.nih.gov/gene/?term=475816 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013720 4758 NEU1 http://www.ncbi.nlm.nih.gov/gene/?term=4758 "NANH, NEU, SIAL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013721 4758 NEU1 http://www.ncbi.nlm.nih.gov/gene/?term=4758 "NANH, NEU, SIAL1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013722 475 ATOX1 http://www.ncbi.nlm.nih.gov/gene/?term=475 "ATX1, HAH1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013723 475 ATOX1 http://www.ncbi.nlm.nih.gov/gene/?term=475 "ATX1, HAH1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013724 476015 SF3B2 http://www.ncbi.nlm.nih.gov/gene/?term=476015 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013725 476070 MAD2L1 http://www.ncbi.nlm.nih.gov/gene/?term=476070 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013726 47611 Gpo-1 http://www.ncbi.nlm.nih.gov/gene/?term=47611 "Dmel_CG8256, 1(2) K05713, CG 8256, CG18786, CG8256, Dmel\CG8256, GPO, GPO-1, Gpo, alpha-GPO, alphaGPO, anon-WO0118547.114, l(2)k05713 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013727 476156 TXNL4A http://www.ncbi.nlm.nih.gov/gene/?term=476156 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013728 476206 RPS12 http://www.ncbi.nlm.nih.gov/gene/?term=476206 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013729 476258 SOD2 http://www.ncbi.nlm.nih.gov/gene/?term=476258 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013730 476311 GKAP1 http://www.ncbi.nlm.nih.gov/gene/?term=476311 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013731 476366 RPS5 http://www.ncbi.nlm.nih.gov/gene/?term=476366 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013732 4763 NF1 http://www.ncbi.nlm.nih.gov/gene/?term=4763 "NFNS, VRNF, WSS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013733 4763 NF1 http://www.ncbi.nlm.nih.gov/gene/?term=4763 "NFNS, VRNF, WSS " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013734 476476 POLR2I http://www.ncbi.nlm.nih.gov/gene/?term=476476 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013735 476567 THOC7 http://www.ncbi.nlm.nih.gov/gene/?term=476567 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013736 476601 RPL29 http://www.ncbi.nlm.nih.gov/gene/?term=476601 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013737 476603 PCBP4 http://www.ncbi.nlm.nih.gov/gene/?term=476603 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013738 476766 CEP57 http://www.ncbi.nlm.nih.gov/gene/?term=476766 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013739 476804 RPS3 http://www.ncbi.nlm.nih.gov/gene/?term=476804 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013740 476895 CCDC34 http://www.ncbi.nlm.nih.gov/gene/?term=476895 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013741 476924 TPT1 http://www.ncbi.nlm.nih.gov/gene/?term=476924 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013742 476935 WBP4 http://www.ncbi.nlm.nih.gov/gene/?term=476935 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013743 476946 COMMD6 http://www.ncbi.nlm.nih.gov/gene/?term=476946 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013744 476968 RAP2A http://www.ncbi.nlm.nih.gov/gene/?term=476968 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013745 476974 CLYBL http://www.ncbi.nlm.nih.gov/gene/?term=476974 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013746 476 ATP1A1 http://www.ncbi.nlm.nih.gov/gene/?term=476 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013747 476 ATP1A1 http://www.ncbi.nlm.nih.gov/gene/?term=476 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013748 477031 RPL14 http://www.ncbi.nlm.nih.gov/gene/?term=477031 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013749 477042 FTL http://www.ncbi.nlm.nih.gov/gene/?term=477042 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013750 477046 RPL15 http://www.ncbi.nlm.nih.gov/gene/?term=477046 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013751 477082 MRAS http://www.ncbi.nlm.nih.gov/gene/?term=477082 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell In situ hybridization Figure 5: Validation and expression of pseudopodial enriched mRNAs and gene products. Data are collected from Figur 5. RLID00013752 477082 MRAS http://www.ncbi.nlm.nih.gov/gene/?term=477082 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013753 477099 TFDP2 http://www.ncbi.nlm.nih.gov/gene/?term=477099 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013754 477143 POLR3F http://www.ncbi.nlm.nih.gov/gene/?term=477143 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013755 477146 CSRP2BP http://www.ncbi.nlm.nih.gov/gene/?term=477146 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013756 477147 DSTN http://www.ncbi.nlm.nih.gov/gene/?term=477147 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013757 477160 PLCB4 http://www.ncbi.nlm.nih.gov/gene/?term=477160 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013758 4771 NF2 http://www.ncbi.nlm.nih.gov/gene/?term=4771 "ACN, BANF, SCH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013759 4771 NF2 http://www.ncbi.nlm.nih.gov/gene/?term=4771 "ACN, BANF, SCH " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013760 4771 NF2 http://www.ncbi.nlm.nih.gov/gene/?term=4771 "ACN, BANF, SCH " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013761 4771 NF2 http://www.ncbi.nlm.nih.gov/gene/?term=4771 "ACN, BANF, SCH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013762 477259 DDX27 http://www.ncbi.nlm.nih.gov/gene/?term=477259 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013763 477297 UFM1 http://www.ncbi.nlm.nih.gov/gene/?term=477297 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013764 4772 NFATC1 http://www.ncbi.nlm.nih.gov/gene/?term=4772 "NF-ATC, NF-ATc1.2, NFAT2, NFATc " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013765 477308 RFC3 http://www.ncbi.nlm.nih.gov/gene/?term=477308 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013766 477329 GTF3A http://www.ncbi.nlm.nih.gov/gene/?term=477329 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013767 477488 PTPN11 http://www.ncbi.nlm.nih.gov/gene/?term=477488 SHP-2 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell In situ hybridization Figure 5: Validation and expression of pseudopodial enriched mRNAs and gene products. Data are collected from Figur 5. RLID00013768 477488 PTPN11 http://www.ncbi.nlm.nih.gov/gene/?term=477488 SHP-2 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013769 4774 NFIA http://www.ncbi.nlm.nih.gov/gene/?term=4774 "CTF, NF-I/A, NF1-A, NFI-A, NFI-L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013770 4774 NFIA http://www.ncbi.nlm.nih.gov/gene/?term=4774 "CTF, NF-I/A, NF1-A, NFI-A, NFI-L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013771 4775 NFATC3 http://www.ncbi.nlm.nih.gov/gene/?term=4775 "NFAT4, NFATX " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013772 4775 NFATC3 http://www.ncbi.nlm.nih.gov/gene/?term=4775 "NFAT4, NFATX " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013773 4775 NFATC3 http://www.ncbi.nlm.nih.gov/gene/?term=4775 "NFAT4, NFATX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013774 477640 ZCRB1 http://www.ncbi.nlm.nih.gov/gene/?term=477640 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013775 47765 c(3)G http://www.ncbi.nlm.nih.gov/gene/?term=47765 "Dmel_CG17604, C(3)G, C3G, CG17604, Dmel\CG17604, c(3)g, c3G, cx " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013776 47765 c(3)G http://www.ncbi.nlm.nih.gov/gene/?term=47765 "Dmel_CG17604, C(3)G, C3G, CG17604, Dmel\CG17604, c(3)g, c3G, cx " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013777 477660 MRPS35 http://www.ncbi.nlm.nih.gov/gene/?term=477660 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013778 477664 MED21 http://www.ncbi.nlm.nih.gov/gene/?term=477664 SURB7 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013779 477813 GSTO1 http://www.ncbi.nlm.nih.gov/gene/?term=477813 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013780 47781 fs(1)K10 http://www.ncbi.nlm.nih.gov/gene/?term=47781 "Dmel_CG3218, CG3218, Dmel\CG3218, EG:30B8.5, K-10, K10, f(s)K10, fs(1)M9, fs(1)k10, k10 " mRNA Drosophila melanogaster 17923096 Apical Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00013781 47781 fs(1)K10 http://www.ncbi.nlm.nih.gov/gene/?term=47781 "Dmel_CG3218, CG3218, Dmel\CG3218, EG:30B8.5, K-10, K10, f(s)K10, fs(1)M9, fs(1)k10, k10 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013782 47781 fs(1)K10 http://www.ncbi.nlm.nih.gov/gene/?term=47781 "Dmel_CG3218, CG3218, Dmel\CG3218, EG:30B8.5, K-10, K10, f(s)K10, fs(1)M9, fs(1)k10, k10 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013783 477876 RB1CC1 http://www.ncbi.nlm.nih.gov/gene/?term=477876 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013784 477879 TCEA1 http://www.ncbi.nlm.nih.gov/gene/?term=477879 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013785 477884 RAB28 http://www.ncbi.nlm.nih.gov/gene/?term=477884 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013786 4778 NFE2 http://www.ncbi.nlm.nih.gov/gene/?term=4778 "NF-E2, p45 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013787 477912 RPL7 http://www.ncbi.nlm.nih.gov/gene/?term=477912 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013788 477913 STAU2 http://www.ncbi.nlm.nih.gov/gene/?term=477913 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013789 477919 MRPS28 http://www.ncbi.nlm.nih.gov/gene/?term=477919 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013790 477939 TMEM55A http://www.ncbi.nlm.nih.gov/gene/?term=477939 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013791 477990 STAM http://www.ncbi.nlm.nih.gov/gene/?term=477990 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013792 477995 SUV39H2 http://www.ncbi.nlm.nih.gov/gene/?term=477995 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013793 4779 NFE2L1 http://www.ncbi.nlm.nih.gov/gene/?term=4779 "LCR-F1, NRF1, TCF11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013794 4779 NFE2L1 http://www.ncbi.nlm.nih.gov/gene/?term=4779 "LCR-F1, NRF1, TCF11 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00013795 4779 NFE2L1 http://www.ncbi.nlm.nih.gov/gene/?term=4779 "LCR-F1, NRF1, TCF11 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013796 4779 NFE2L1 http://www.ncbi.nlm.nih.gov/gene/?term=4779 "NRF1, TCF11, LCR-F1 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00013797 478023 ZMYND11 http://www.ncbi.nlm.nih.gov/gene/?term=478023 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013798 478053 PPP2R2B http://www.ncbi.nlm.nih.gov/gene/?term=478053 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013799 478076 CWC27 http://www.ncbi.nlm.nih.gov/gene/?term=478076 SDCCAG10 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013800 478091 MCCC2 http://www.ncbi.nlm.nih.gov/gene/?term=478091 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013801 478097 ANKRA2 http://www.ncbi.nlm.nih.gov/gene/?term=478097 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013802 4780 NFE2L2 http://www.ncbi.nlm.nih.gov/gene/?term=4780 "HEBP1, NRF2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013803 4780 NFE2L2 http://www.ncbi.nlm.nih.gov/gene/?term=4780 "HEBP1, NRF2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013804 4780 NFE2L2 http://www.ncbi.nlm.nih.gov/gene/?term=4780 "HEBP1, NRF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013805 478149 RBBP4 http://www.ncbi.nlm.nih.gov/gene/?term=478149 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013806 478188 TCEB3 http://www.ncbi.nlm.nih.gov/gene/?term=478188 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013807 478190 TCEA3 http://www.ncbi.nlm.nih.gov/gene/?term=478190 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013808 4781 NFIB http://www.ncbi.nlm.nih.gov/gene/?term=4781 "CTF, HMGIC/NFIB, NF-I/B, NF1-B, NFI-B, NFI-RED2, NFIB3, NFIB " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013809 478295 COPS2 http://www.ncbi.nlm.nih.gov/gene/?term=478295 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013810 4782 NFIC http://www.ncbi.nlm.nih.gov/gene/?term=4782 "CTF, CTF5, NF-I, NFI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013811 4782 NFIC http://www.ncbi.nlm.nih.gov/gene/?term=4782 "CTF, CTF5, NF-I, NFI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013812 478312 MYO5A http://www.ncbi.nlm.nih.gov/gene/?term=478312 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013813 478398 USP16 http://www.ncbi.nlm.nih.gov/gene/?term=478398 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013814 4783 NFIL3 http://www.ncbi.nlm.nih.gov/gene/?term=4783 "E4BP4, IL3BP1, NF-IL3A, NFIL3A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013815 478452 ENOPH1 http://www.ncbi.nlm.nih.gov/gene/?term=478452 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013816 4784 NFIX http://www.ncbi.nlm.nih.gov/gene/?term=4784 "MRSHSS, NF1A, SOTOS2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013817 4784 NFIX http://www.ncbi.nlm.nih.gov/gene/?term=4784 "MRSHSS, NF1A, SOTOS2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013818 478637 ACTL6A http://www.ncbi.nlm.nih.gov/gene/?term=478637 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013819 478639 NDUFB5 http://www.ncbi.nlm.nih.gov/gene/?term=478639 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013820 478670 LPP http://www.ncbi.nlm.nih.gov/gene/?term=478670 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013821 478717 EEF1E1 http://www.ncbi.nlm.nih.gov/gene/?term=478717 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013822 478725 TBC1D7 http://www.ncbi.nlm.nih.gov/gene/?term=478725 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013823 478726 SIRT5 http://www.ncbi.nlm.nih.gov/gene/?term=478726 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013824 478770 GRB14 http://www.ncbi.nlm.nih.gov/gene/?term=478770 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013825 478779 STK39 http://www.ncbi.nlm.nih.gov/gene/?term=478779 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013826 478788 METTL5 http://www.ncbi.nlm.nih.gov/gene/?term=478788 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013827 478855 HSPE1 http://www.ncbi.nlm.nih.gov/gene/?term=478855 "MOB4, MOBKL3, PREI3 " mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013828 478897 LANCL1 http://www.ncbi.nlm.nih.gov/gene/?term=478897 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013829 478 ATP1A3 http://www.ncbi.nlm.nih.gov/gene/?term=478 "AHC2, CAPOS, DYT12, RDP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013830 479057 BTBD1 http://www.ncbi.nlm.nih.gov/gene/?term=479057 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013831 479059 HDGFRP3 http://www.ncbi.nlm.nih.gov/gene/?term=479059 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013832 479066 IDH3A http://www.ncbi.nlm.nih.gov/gene/?term=479066 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013833 4790 NFKB1 http://www.ncbi.nlm.nih.gov/gene/?term=4790 "CVID12, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013834 4790 NFKB1 http://www.ncbi.nlm.nih.gov/gene/?term=4790 "CVID12, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013835 4790 NFKB1 http://www.ncbi.nlm.nih.gov/gene/?term=4790 "CVID12, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013836 479238 PPA1 http://www.ncbi.nlm.nih.gov/gene/?term=479238 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013837 4792 NFKBIA http://www.ncbi.nlm.nih.gov/gene/?term=4792 "IKBA, MAD-3, NFKBI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013838 4792 NFKBIA http://www.ncbi.nlm.nih.gov/gene/?term=4792 "IKBA, MAD-3, NFKBI " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013839 4792 NFKBIA http://www.ncbi.nlm.nih.gov/gene/?term=4792 "IKBA, MAD-3, NFKBI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013840 479331 CSNK1A1 http://www.ncbi.nlm.nih.gov/gene/?term=479331 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013841 4793 NFKBIB http://www.ncbi.nlm.nih.gov/gene/?term=4793 "IKBB, TRIP9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013842 4793 NFKBIB http://www.ncbi.nlm.nih.gov/gene/?term=4793 "IKBB, TRIP9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013843 479532 TMEM11 http://www.ncbi.nlm.nih.gov/gene/?term=479532 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013844 479605 KIF1B http://www.ncbi.nlm.nih.gov/gene/?term=479605 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013845 479636 DYNLRB2 http://www.ncbi.nlm.nih.gov/gene/?term=479636 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013846 479693 DYNC1LI2 http://www.ncbi.nlm.nih.gov/gene/?term=479693 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013847 4796 TONSL http://www.ncbi.nlm.nih.gov/gene/?term=4796 "IKBR, NFKBIL2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013848 4796 TONSL http://www.ncbi.nlm.nih.gov/gene/?term=4796 "IKBR, NFKBIL2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013849 4796 TONSL http://www.ncbi.nlm.nih.gov/gene/?term=4796 "IKBR, NFKBIL2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013850 479745 ARPC1A http://www.ncbi.nlm.nih.gov/gene/?term=479745 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell In situ hybridization Figure 5: Validation and expression of pseudopodial enriched mRNAs and gene products. Data are collected from Figur 5. RLID00013851 479745 ARPC1A http://www.ncbi.nlm.nih.gov/gene/?term=479745 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013852 479776 BCKDK http://www.ncbi.nlm.nih.gov/gene/?term=479776 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013853 4798 NFRKB http://www.ncbi.nlm.nih.gov/gene/?term=4798 INO80G mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013854 4798 NFRKB http://www.ncbi.nlm.nih.gov/gene/?term=4798 INO80G mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013855 4799 NFX1 http://www.ncbi.nlm.nih.gov/gene/?term=4799 "NFX2, TEG-42, Tex42 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013856 4799 NFX1 http://www.ncbi.nlm.nih.gov/gene/?term=4799 "NFX2, TEG-42, Tex42 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013857 479 ATP12A http://www.ncbi.nlm.nih.gov/gene/?term=479 "#945, ATP1AL1, HK " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013858 479 ATP12A http://www.ncbi.nlm.nih.gov/gene/?term=479 "#945, ATP1AL1, HK " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013859 47 ACLY http://www.ncbi.nlm.nih.gov/gene/?term=47 "ACL, ATPCL, CLATP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013860 47 ACLY http://www.ncbi.nlm.nih.gov/gene/?term=47 "ACL, ATPCL, CLATP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013861 47 ACLY http://www.ncbi.nlm.nih.gov/gene/?term=47 "ACL, ATPCL, CLATP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013862 4800 NFYA http://www.ncbi.nlm.nih.gov/gene/?term=4800 "CBF-A, CBF-B, HAP2, NF-YA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013863 480146 HDHD2 http://www.ncbi.nlm.nih.gov/gene/?term=480146 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013864 480147 PIAS2 http://www.ncbi.nlm.nih.gov/gene/?term=480147 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013865 480149 ATP5A1 http://www.ncbi.nlm.nih.gov/gene/?term=480149 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013866 480165 RNF138 http://www.ncbi.nlm.nih.gov/gene/?term=480165 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013867 4801 NFYB http://www.ncbi.nlm.nih.gov/gene/?term=4801 "CBF-A, CBF-B, HAP3, NF-YB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013868 480221 LOC480221 http://www.ncbi.nlm.nih.gov/gene/?term=480221 "RPL17, RPL17L " mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013869 480242 PRMT5 http://www.ncbi.nlm.nih.gov/gene/?term=480242 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013870 4802 NFYC http://www.ncbi.nlm.nih.gov/gene/?term=4802 "CBF-C, CBFC, H1TF2A, HAP5, HSM, NF-YC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013871 480326 DDHD1 http://www.ncbi.nlm.nih.gov/gene/?term=480326 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013872 480513 BECN1 http://www.ncbi.nlm.nih.gov/gene/?term=480513 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013873 480519 DNAJC7 http://www.ncbi.nlm.nih.gov/gene/?term=480519 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013874 4807 NHLH1 http://www.ncbi.nlm.nih.gov/gene/?term=4807 "HEN1, NSCL, NSCL1, bHLHa35 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013875 480830 SLC25A6 http://www.ncbi.nlm.nih.gov/gene/?term=480830 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013876 480897 CDK16 http://www.ncbi.nlm.nih.gov/gene/?term=480897 PCTK1 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013877 480986 TIMM8A http://www.ncbi.nlm.nih.gov/gene/?term=480986 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013878 4809 SNU13 http://www.ncbi.nlm.nih.gov/gene/?term=4809 "15.5K, FA-1, FA1, NHP2L1, NHPX, OTK27, SNRNP15-5, SPAG12, SSFA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013879 4809 SNU13 http://www.ncbi.nlm.nih.gov/gene/?term=4809 "15.5K, FA-1, FA1, NHP2L1, NHPX, OTK27, SNRNP15-5, SPAG12, SSFA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013880 481038 MCTS1 http://www.ncbi.nlm.nih.gov/gene/?term=481038 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013881 481049 ZNF280C http://www.ncbi.nlm.nih.gov/gene/?term=481049 SUHW3 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013882 481063 RBMX http://www.ncbi.nlm.nih.gov/gene/?term=481063 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013883 481070 FMR1 http://www.ncbi.nlm.nih.gov/gene/?term=481070 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013884 4811 NID1 http://www.ncbi.nlm.nih.gov/gene/?term=4811 NID mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013885 4811 NID1 http://www.ncbi.nlm.nih.gov/gene/?term=4811 NID mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013886 4814 NINJ1 http://www.ncbi.nlm.nih.gov/gene/?term=4814 "NIN1, NINJURIN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013887 4814 NINJ1 http://www.ncbi.nlm.nih.gov/gene/?term=4814 "NIN1, NINJURIN " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013888 481617 DCAF10 http://www.ncbi.nlm.nih.gov/gene/?term=481617 WDR32 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013889 4818 NKG7 http://www.ncbi.nlm.nih.gov/gene/?term=4818 "GIG1, GMP-17, p15-TIA-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013890 481 ATP1B1 http://www.ncbi.nlm.nih.gov/gene/?term=481 ATP1B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013891 481 ATP1B1 http://www.ncbi.nlm.nih.gov/gene/?term=481 ATP1B mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00013892 481 ATP1B1 http://www.ncbi.nlm.nih.gov/gene/?term=481 ATP1B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013893 4820 NKTR http://www.ncbi.nlm.nih.gov/gene/?term=4820 p104 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013894 4828 NMB http://www.ncbi.nlm.nih.gov/gene/?term=4828 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013895 482916 ING2 http://www.ncbi.nlm.nih.gov/gene/?term=482916 INGX mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013896 482992 UBXN2A http://www.ncbi.nlm.nih.gov/gene/?term=482992 UBXD4 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013897 482 ATP1B2 http://www.ncbi.nlm.nih.gov/gene/?term=482 AMOG mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013898 482 ATP1B2 http://www.ncbi.nlm.nih.gov/gene/?term=482 AMOG mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013899 482 ATP1B2 http://www.ncbi.nlm.nih.gov/gene/?term=482 AMOG mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013900 4830 NME1 http://www.ncbi.nlm.nih.gov/gene/?term=4830 "AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013901 4830 NME1 http://www.ncbi.nlm.nih.gov/gene/?term=4830 "AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013902 4830 NME1 http://www.ncbi.nlm.nih.gov/gene/?term=4830 "AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013903 48317 ttk http://www.ncbi.nlm.nih.gov/gene/?term=48317 "Dmel_CG1856, 0037/17, 0250/25, 0438/31, 0702/07, 1049/07, 1119/04, 1184/16, 1209/05, 1209/10, 1260/10, 1281/04, 1325/15, 1372/08, 1396/14, 1418/06, 3540, 5125, 5311, CG11558, CG1856, Dmel\CG1856, E(yan)100D, FTZ-F2, TTK, TTK69, TTK88, TTKA, Ttk, Ttk69, Ttk88, anon-EST:Liang-2.9, clone 2.9, ftz-f2, ftzf2/ttk, l(3)02667, l(3)j2A1, l(3)j7B8, osn, oss, ovs, tramtrak/FTZ-F2, ttk69, ttkp69, twk, ttk " mRNA Drosophila melanogaster 18956321 Germ plasm Embryo In situ hybridization "Our in situ hybridization analysis revealed that 27 of the 68 transcripts were enriched in the germ plasm. Among the 27 transcripts, six were found to be required for germline-specific gene expression of vasa and/or nanos by knockdown experiments using RNA interference (RNAi). The identified transcripts encode a transcriptional activator (ovo), components of the transcriptional initiation complexes (Trf2, bip2 and Tif-IA), and the Ccr4-Not complex (CG31716 and l(2)NC136). " RLID00013904 48317 ttk http://www.ncbi.nlm.nih.gov/gene/?term=48317 "Dmel_CG1856, 0037/17, 0250/25, 0438/31, 0702/07, 1049/07, 1119/04, 1184/16, 1209/05, 1209/10, 1260/10, 1281/04, 1325/15, 1372/08, 1396/14, 1418/06, 3540, 5125, 5311, CG11558, CG1856, Dmel\CG1856, E(yan)100D, FTZ-F2, TTK, TTK69, TTK88, TTKA, Ttk, Ttk69, Ttk88, anon-EST:Liang-2.9, clone 2.9, ftz-f2, ftzf2/ttk, l(3)02667, l(3)j2A1, l(3)j7B8, osn, oss, ovs, tramtrak/FTZ-F2, ttk69, ttkp69, twk, ttk " mRNA Drosophila melanogaster 17923096 Posterior Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00013905 48317 ttk http://www.ncbi.nlm.nih.gov/gene/?term=48317 "Dmel_CG1856, 0037/17, 0250/25, 0438/31, 0702/07, 1049/07, 1119/04, 1184/16, 1209/05, 1209/10, 1260/10, 1281/04, 1325/15, 1372/08, 1396/14, 1418/06, 3540, 5125, 5311, CG11558, CG1856, Dmel\CG1856, E(yan)100D, FTZ-F2, TTK, TTK69, TTK88, TTKA, Ttk, Ttk69, Ttk88, anon-EST:Liang-2.9, clone 2.9, ftz-f2, ftzf2/ttk, l(3)02667, l(3)j2A1, l(3)j7B8, osn, oss, ovs, tramtrak/FTZ-F2, ttk69, ttkp69, twk, ttk " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013906 483282 COG1 http://www.ncbi.nlm.nih.gov/gene/?term=483282 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013907 4832 NME3 http://www.ncbi.nlm.nih.gov/gene/?term=4832 "DR-nm23, NDPK-C, NDPKC, NM23-H3, NM23H3, c371H6.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013908 4832 NME3 http://www.ncbi.nlm.nih.gov/gene/?term=4832 "DR-nm23, NDPK-C, NDPKC, NM23-H3, NM23H3, c371H6.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013909 483338 SEC14L1 http://www.ncbi.nlm.nih.gov/gene/?term=483338 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013910 4833 NME4 http://www.ncbi.nlm.nih.gov/gene/?term=4833 "NDPK-D, NM23H4, nm23-H4 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013911 4833 NME4 http://www.ncbi.nlm.nih.gov/gene/?term=4833 "NDPK-D, NM23H4, nm23-H4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013912 483424 TRIM44 http://www.ncbi.nlm.nih.gov/gene/?term=483424 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013913 4835 NQO2 http://www.ncbi.nlm.nih.gov/gene/?term=4835 "DHQV, DIA6, NMOR2, QR2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013914 4835 NQO2 http://www.ncbi.nlm.nih.gov/gene/?term=4835 "DHQV, DIA6, NMOR2, QR2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013915 4835 NQO2 http://www.ncbi.nlm.nih.gov/gene/?term=4835 "DHQV, DIA6, NMOR2, QR2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013916 4836 NMT1 http://www.ncbi.nlm.nih.gov/gene/?term=4836 NMT mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013917 4836 NMT1 http://www.ncbi.nlm.nih.gov/gene/?term=4836 NMT mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013918 4836 NMT1 http://www.ncbi.nlm.nih.gov/gene/?term=4836 NMT mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013919 4837 NNMT http://www.ncbi.nlm.nih.gov/gene/?term=4837 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013920 4839 NOP2 http://www.ncbi.nlm.nih.gov/gene/?term=4839 "NOL1, NOP120, NSUN1, p120 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013921 4839 NOP2 http://www.ncbi.nlm.nih.gov/gene/?term=4839 "NOL1, NOP120, NSUN1, p120 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013922 483 ATP1B3 http://www.ncbi.nlm.nih.gov/gene/?term=483 "ATPB-3, CD298 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013923 483 ATP1B3 http://www.ncbi.nlm.nih.gov/gene/?term=483 "ATPB-3, CD298 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013924 483 ATP1B3 http://www.ncbi.nlm.nih.gov/gene/483 "CD298, ATPB-3 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00013925 484176 CBWD2 http://www.ncbi.nlm.nih.gov/gene/?term=484176 CBWD1 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013926 4841 NONO http://www.ncbi.nlm.nih.gov/gene/?term=4841 "MRXS34, NMT55, NRB54, P54, P54NRB, PPP1R114 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013927 4841 NONO http://www.ncbi.nlm.nih.gov/gene/?term=4841 "MRXS34, NMT55, NRB54, P54, P54NRB, PPP1R114 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013928 4841 NONO http://www.ncbi.nlm.nih.gov/gene/?term=4841 "MRXS34, NMT55, NRB54, P54, P54NRB, PPP1R114 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013929 4841 NONO http://www.ncbi.nlm.nih.gov/gene/?term=4841 "NMT55, NRB54, P54, P54NRB, PPP1R114 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013930 48440 Kebab http://www.ncbi.nlm.nih.gov/gene/?term=48440 "Dmel_CG31672, BEST:LD15963, CG31672, CG4248, Dmel\CG31672, keb, kebab, n(2)k09932 " mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013931 48440 Kebab http://www.ncbi.nlm.nih.gov/gene/?term=48440 "Dmel_CG31672, BEST:LD15963, CG31672, CG4248, Dmel\CG31672, keb, kebab, n(2)k09932 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013932 48445 Acph-1 http://www.ncbi.nlm.nih.gov/gene/?term=48445 "Dmel_CG7899, ACP, ACPH, APH, Acph, CG7899, Dmel\CG7899 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013933 484820 ELL http://www.ncbi.nlm.nih.gov/gene/?term=484820 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013934 4848 CNOT2 http://www.ncbi.nlm.nih.gov/gene/?term=4848 "CDC36, HSPC131, NOT2, NOT2H " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013935 4848 CNOT2 http://www.ncbi.nlm.nih.gov/gene/?term=4848 "CDC36, HSPC131, NOT2, NOT2H " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013936 4848 CNOT2 http://www.ncbi.nlm.nih.gov/gene/?term=4848 "CDC36, HSPC131, NOT2, NOT2H " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013937 4849 CNOT3 http://www.ncbi.nlm.nih.gov/gene/?term=4849 "LENG2, NOT3, NOT3H " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013938 4849 CNOT3 http://www.ncbi.nlm.nih.gov/gene/?term=4849 "LENG2, NOT3, NOT3H " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013939 4850 CNOT4 http://www.ncbi.nlm.nih.gov/gene/?term=4850 "CLONE243, NOT4, NOT4H " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013940 4853 NOTCH2 http://www.ncbi.nlm.nih.gov/gene/?term=4853 "AGS2, HJCYS, hN2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013941 4853 NOTCH2 http://www.ncbi.nlm.nih.gov/gene/?term=4853 "AGS2, HJCYS, hN2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013942 4854 NOTCH3 http://www.ncbi.nlm.nih.gov/gene/?term=4854 "CADASIL, CADASIL1, CASIL, IMF2, LMNS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013943 48552 Sam-S http://www.ncbi.nlm.nih.gov/gene/?term=48552 "Dmel_CG2674, CG2674, Dmel\CG2674, M(2)21A-B, M(2)21AB, METK, SamS, Su(z)5, m(2)21ab " mRNA Drosophila melanogaster 25838129 Perinuclear Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013944 4855 NOTCH4 http://www.ncbi.nlm.nih.gov/gene/?term=4855 INT3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013945 485684 ARMC8 http://www.ncbi.nlm.nih.gov/gene/?term=485684 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013946 48572 Hsp60B http://www.ncbi.nlm.nih.gov/gene/?term=48572 "Dmel_CG2830, 152031_at, CG2830, Dmel\CG2830, Hsp60b, anon-WO0140519.61, hsp60B, ms(2)06619, ms(2)21D " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013947 485756 BFSP1 http://www.ncbi.nlm.nih.gov/gene/?term=485756 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013948 485837 SNTA1 http://www.ncbi.nlm.nih.gov/gene/?term=485837 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell In situ hybridization Figure 5: Validation and expression of pseudopodial enriched mRNAs and gene products. Data are collected from Figur 5. RLID00013949 485837 SNTA1 http://www.ncbi.nlm.nih.gov/gene/?term=485837 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013950 485856 MYL9 http://www.ncbi.nlm.nih.gov/gene/?term=485856 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013951 4860 PNP http://www.ncbi.nlm.nih.gov/gene/?term=4860 "NP, PRO1837, PUNP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013952 4860 PNP http://www.ncbi.nlm.nih.gov/gene/?term=4860 "NP, PRO1837, PUNP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013953 486354 PES1 http://www.ncbi.nlm.nih.gov/gene/?term=486354 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013954 4863 NPAT http://www.ncbi.nlm.nih.gov/gene/?term=4863 "E14, E14/NPAT, p220 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013955 4863 NPAT http://www.ncbi.nlm.nih.gov/gene/?term=4863 "E14, E14/NPAT, p220 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013956 4864 NPC1 http://www.ncbi.nlm.nih.gov/gene/?term=4864 NPC mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013957 4864 NPC1 http://www.ncbi.nlm.nih.gov/gene/?term=4864 NPC mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013958 4869 NPM1 http://www.ncbi.nlm.nih.gov/gene/?term=4869 "B23, NPM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013959 4869 NPM1 http://www.ncbi.nlm.nih.gov/gene/?term=4869 "B23, NPM " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013960 4869 NPM1 http://www.ncbi.nlm.nih.gov/gene/?term=4869 "B23, NPM " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013961 4869 NPM1 http://www.ncbi.nlm.nih.gov/gene/?term=4869 "B23, NPM " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013962 4869 NPM1 http://www.ncbi.nlm.nih.gov/gene/?term=4869 "B23, NPM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013963 487147 NET1 http://www.ncbi.nlm.nih.gov/gene/?term=487147 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013964 487218 ACTBL2 http://www.ncbi.nlm.nih.gov/gene/?term=487218 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell In situ hybridization Figure 5: Validation and expression of pseudopodial enriched mRNAs and gene products. Data are collected from Figur 5. RLID00013965 487233 SREK1 http://www.ncbi.nlm.nih.gov/gene/?term=487233 SFRS12 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013966 488025 TNK2 http://www.ncbi.nlm.nih.gov/gene/?term=488025 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013967 488164 EIF5A2 http://www.ncbi.nlm.nih.gov/gene/?term=488164 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013968 4881 NPR1 http://www.ncbi.nlm.nih.gov/gene/?term=4881 "ANPRA, ANPa, GUC2A, GUCY2A, NPRA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013969 488475 TRAK2 http://www.ncbi.nlm.nih.gov/gene/?term=488475 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013970 488 ATP2A2 http://www.ncbi.nlm.nih.gov/gene/?term=488 "ATP2B, DAR, DD, SERCA2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013971 488 ATP2A2 http://www.ncbi.nlm.nih.gov/gene/?term=488 "ATP2B, DAR, DD, SERCA2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013972 4891 SLC11A2 http://www.ncbi.nlm.nih.gov/gene/?term=4891 "AHMIO1, DCT1, DMT1, NRAMP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013973 4891 SLC11A2 http://www.ncbi.nlm.nih.gov/gene/?term=4891 "DCT1, DMT1, NRAMP2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013974 4892 NRAP http://www.ncbi.nlm.nih.gov/gene/?term=4892 N-RAP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013975 489533 EPN2 http://www.ncbi.nlm.nih.gov/gene/?term=489533 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013976 48973 Src64B http://www.ncbi.nlm.nih.gov/gene/?term=48973 "Dmel_CG7524, C-src1, CG7524, D-Src64B, D-src, DSRC64, DSrc, DSrc64, DSrc64B, Dm SRC1, DmHD-358, Dmel\CG7524, Dsrc, Dsrc64, Dsrc64B, HD-358, MRE5, SRC 64B, SRC64B, Src, Src1, Src64, Src64b, c-src, dSrc, dsrc, src, src1, src64, src64B, src64b " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013977 4897 NRCAM http://www.ncbi.nlm.nih.gov/gene/?term=4897 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013978 4898 NRDC http://www.ncbi.nlm.nih.gov/gene/?term=4898 "NRD1, hNRD1, hNRD2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013979 48 ACO1 http://www.ncbi.nlm.nih.gov/gene/?term=48 "ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013980 48 ACO1 http://www.ncbi.nlm.nih.gov/gene/?term=48 "ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013981 490068 FAHD1 http://www.ncbi.nlm.nih.gov/gene/?term=490068 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013982 4900 NRGN http://www.ncbi.nlm.nih.gov/gene/?term=4900 "RC3, hng " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013983 4902 NRTN http://www.ncbi.nlm.nih.gov/gene/?term=4902 NTN mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013984 4902 NRTN http://www.ncbi.nlm.nih.gov/gene/?term=4902 NTN mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013985 4902 NRTN http://www.ncbi.nlm.nih.gov/gene/?term=4902 NTN mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00013986 4904 YBX1 http://www.ncbi.nlm.nih.gov/gene/?term=4904 "BP-8, CBF-A, CSDA2, CSDB, DBPB, EFI-A, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013987 4905 NSF http://www.ncbi.nlm.nih.gov/gene/?term=4905 SKD2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013988 4905 NSF http://www.ncbi.nlm.nih.gov/gene/?term=4905 SKD2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013989 49070 Mbs http://www.ncbi.nlm.nih.gov/gene/?term=49070 "Dmel_CG32156, 0573/06, 0953/04, CG32156, CG5600, CG5891, DMBS, DMYPT, DMbs, Dmel\CG32156, MBS, Mypt, l(3)03802, l(3)72Dd, l(3)S005331b, l(3)S057306, l(3)S057306b, l(3)S095304, l(3)j3B4, l(3)j7A1, mbs " mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013990 49070 Mbs http://www.ncbi.nlm.nih.gov/gene/?term=49070 "Dmel_CG32156, 0573/06, 0953/04, CG32156, CG5600, CG5891, DMBS, DMYPT, DMbs, Dmel\CG32156, MBS, Mypt, l(3)03802, l(3)72Dd, l(3)S005331b, l(3)S057306, l(3)S057306b, l(3)S095304, l(3)j3B4, l(3)j7A1, mbs " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00013991 490967 STAT3 http://www.ncbi.nlm.nih.gov/gene/?term=490967 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013992 4909 NTF4 http://www.ncbi.nlm.nih.gov/gene/?term=4909 "GLC10, GLC1O, NT-4, NT-4/5, NT-5, NT4, NT5, NTF5 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00013993 4909 NTF4 http://www.ncbi.nlm.nih.gov/gene/?term=4909 "NT4, NT5, NT-4, NT-5, NTF5, GLC10, GLC1O, NT-4/5 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00013994 490 ATP2B1 http://www.ncbi.nlm.nih.gov/gene/?term=490 "PMCA1, PMCA1kb " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013995 490 ATP2B1 http://www.ncbi.nlm.nih.gov/gene/?term=490 "PMCA1, PMCA1kb " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00013996 490 ATP2B1 http://www.ncbi.nlm.nih.gov/gene/?term=490 "PMCA1, PMCA1kb " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00013997 491185 GOSR1 http://www.ncbi.nlm.nih.gov/gene/?term=491185 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00013998 4913 NTHL1 http://www.ncbi.nlm.nih.gov/gene/?term=4913 "FAP3, NTH1, OCTS3, hNTH1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00013999 491539 CIB2 http://www.ncbi.nlm.nih.gov/gene/?term=491539 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00014000 4915 NTRK2 http://www.ncbi.nlm.nih.gov/gene/?term=4915 "GP145-TrkB, TRKB, trk-B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014001 491853 RP2 http://www.ncbi.nlm.nih.gov/gene/?term=491853 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00014002 492030 BEX4 http://www.ncbi.nlm.nih.gov/gene/?term=492030 BEXL1 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00014003 4920 ROR2 http://www.ncbi.nlm.nih.gov/gene/?term=4920 "BDB, BDB1, NTRKR2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014004 49228 mod(mdg4) http://www.ncbi.nlm.nih.gov/gene/?term=49228 "Dmel_CG32491, BcDNA:GH07769, BcDNA:SD03001, CG15500, CG15501, CG15802, CG18151, CG32491, CG7836, CG7859, CG8076, Dmel\CG32491, Doom, E(var)129, E(var)3-93D, E(var)93D, E-(var)3-93D, E-var(3)1, E-var(3)3, MOD(MDG4), MOD(MDG4)56.3, MOD2.2, Mod(mdg 4), Mod(mdg 4)67.2, Mod(mdg)4, Mod(mdg4), Mod(mdg4)-67.2, Mod(mdg4)2.2, Mod(mdg4)67.2, Mod2.2, Mod67.2, Mod[mdg4], bpd, doom, l(3)03852, l(3)L3101, l(3)j2B7, mdg4, mnm, mnn, mod, mod (mdg4), mod(gypsy), mod(mdg-4), mod(mdg4-67.2, mod(mdg4)67.2, mod2.2, modMDG4, mod[mdg4], pf-2, mod(mdg4) " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00014005 4922 NTS http://www.ncbi.nlm.nih.gov/gene/?term=4922 "NMN-125, NN, NT, NT/N1, NTS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014006 4924 NUCB1 http://www.ncbi.nlm.nih.gov/gene/?term=4924 "CALNUC, NUC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014007 4924 NUCB1 http://www.ncbi.nlm.nih.gov/gene/?term=4924 "CALNUC, NUC " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014008 4924 NUCB1 http://www.ncbi.nlm.nih.gov/gene/?term=4924 "NUC, CALNUC " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00014009 4925 NUCB2 http://www.ncbi.nlm.nih.gov/gene/?term=4925 "HEL-S-109, NEFA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014010 4925 NUCB2 http://www.ncbi.nlm.nih.gov/gene/?term=4925 "HEL-S-109, NEFA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014011 4925 NUCB2 http://www.ncbi.nlm.nih.gov/gene/?term=4925 "HEL-S-109, NEFA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014012 4925 NUCB2 http://www.ncbi.nlm.nih.gov/gene/?term=4925 "NEFA, HEL-S-109 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00014013 4926 NUMA1 http://www.ncbi.nlm.nih.gov/gene/?term=4926 "NMP-22, NUMA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014014 4926 NUMA1 http://www.ncbi.nlm.nih.gov/gene/?term=4926 "NMP-22, NUMA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014015 4927 NUP88 http://www.ncbi.nlm.nih.gov/gene/?term=4927 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014016 4927 NUP88 http://www.ncbi.nlm.nih.gov/gene/?term=4927 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014017 4928 NUP98 http://www.ncbi.nlm.nih.gov/gene/?term=4928 "ADIR2, NUP196, NUP96 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014018 4928 NUP98 http://www.ncbi.nlm.nih.gov/gene/?term=4928 "ADIR2, NUP196, NUP96 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014019 4931 NVL http://www.ncbi.nlm.nih.gov/gene/?term=4931 NVL2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014020 493753 COA5 http://www.ncbi.nlm.nih.gov/gene/?term=493753 "6330578E17Rik, C2orf64, CEMCOX3, Pet191 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014021 493856 CISD2 http://www.ncbi.nlm.nih.gov/gene/?term=493856 "ERIS, Miner1, NAF-1, WFS2, ZCD2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014022 493856 CISD2 http://www.ncbi.nlm.nih.gov/gene/?term=493856 "ERIS, Miner1, NAF-1, WFS2, ZCD2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014023 493869 GPX8 http://www.ncbi.nlm.nih.gov/gene/?term=493869 "EPLA847, GPx-8, GSHPx-8, UNQ847 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014024 4938 OAS1 http://www.ncbi.nlm.nih.gov/gene/?term=4938 "E18/E16, IFI-4, OIAS, OIASI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014025 493 ATP2B4 http://www.ncbi.nlm.nih.gov/gene/?term=493 "ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014026 4940 OAS3 http://www.ncbi.nlm.nih.gov/gene/?term=4940 "p100, p100OAS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014027 494115 RBMXL1 http://www.ncbi.nlm.nih.gov/gene/?term=494115 RBM1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014028 494143 CHAC2 http://www.ncbi.nlm.nih.gov/gene/?term=494143 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014029 4942 OAT http://www.ncbi.nlm.nih.gov/gene/?term=4942 "GACR, HOGAASE, OKT, OAT " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014030 4942 OAT http://www.ncbi.nlm.nih.gov/gene/?term=4942 "GACR, HOGAASE, OKT, OAT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014031 4942 OAT http://www.ncbi.nlm.nih.gov/gene/?term=4942 "GACR, HOGA, OATASE, OKT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014032 494448 Cbx6 http://www.ncbi.nlm.nih.gov/gene/?term=494448 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014033 494468 Armcx5 http://www.ncbi.nlm.nih.gov/gene/?term=494468 AW556585 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014034 4946 OAZ1 http://www.ncbi.nlm.nih.gov/gene/?term=4946 "AZI, OAZ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014035 4946 OAZ1 http://www.ncbi.nlm.nih.gov/gene/?term=4946 "AZI, OAZ " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014036 4947 OAZ2 http://www.ncbi.nlm.nih.gov/gene/?term=4947 AZ2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014037 4947 OAZ2 http://www.ncbi.nlm.nih.gov/gene/?term=4947 AZ2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014038 4948 OCA2 http://www.ncbi.nlm.nih.gov/gene/?term=4948 "BEY, BEY1, BEY2, BOCA, D15S12, EYCL, EYCL2, EYCL3, HCL3, P, PED, SHEP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014039 495071 LOC495071 http://www.ncbi.nlm.nih.gov/gene/?term=495071 mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00014040 495252 lima1 http://www.ncbi.nlm.nih.gov/gene/?term=495252 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00014041 4952 OCRL http://www.ncbi.nlm.nih.gov/gene/?term=4952 "INPP5F, LOCR, NPHL2, OCRL-1, OCRL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014042 4953 ODC1 http://www.ncbi.nlm.nih.gov/gene/?term=4953 ODC mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014043 4953 ODC1 http://www.ncbi.nlm.nih.gov/gene/?term=4953 ODC mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014044 4953 ODC1 http://www.ncbi.nlm.nih.gov/gene/?term=4953 ODC mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014045 4953 ODC1 http://www.ncbi.nlm.nih.gov/gene/?term=4953 ODC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014046 495440 atp2a3 http://www.ncbi.nlm.nih.gov/gene/?term=495440 serca3 mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00014047 4957 ODF2 http://www.ncbi.nlm.nih.gov/gene/?term=4957 "CT134, ODF2/1, ODF2/2, ODF84 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014048 495823 ccni-b http://www.ncbi.nlm.nih.gov/gene/?term=495823 "cyc1, cyi " mRNA Xenopus laevis 20503379 Vegetal Oocyte RT-PCR Figure1: Confirmation of vegetal cortex enrichment of selected genes. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of novel cortex-enriched transcript expression in whole oocyte (Oo) and vegetal cortex (VgCx) samples. The-RT lane is an oocyte sample processed in the absence of reverse transcriptase. ornithine decarboxylase (odc) is shown as a loading control. Data are collected from Figure 1. RLID00014049 4967 OGDH http://www.ncbi.nlm.nih.gov/gene/?term=4967 "AKGDH, E1k, OGDC " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014050 4967 OGDH http://www.ncbi.nlm.nih.gov/gene/?term=4967 "AKGDH, E1k, OGDC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014051 4968 OGG1 http://www.ncbi.nlm.nih.gov/gene/?term=4968 "HMMH, HOGG1, MUTM, OGH1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014052 4974 OMG http://www.ncbi.nlm.nih.gov/gene/?term=4974 OMGP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014053 497652 Acd http://www.ncbi.nlm.nih.gov/gene/?term=497652 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014054 497661 C18orf32 http://www.ncbi.nlm.nih.gov/gene/?term=497661 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014055 4976 OPA1 http://www.ncbi.nlm.nih.gov/gene/?term=4976 "BERHS, MGM1, MTDPS14, NPG, NTG, largeG " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014056 4976 OPA1 http://www.ncbi.nlm.nih.gov/gene/?term=4976 "MGM1, NPG, NTG, largeG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014057 4978 OPCML http://www.ncbi.nlm.nih.gov/gene/?term=4978 "IGLON1, OBCAM, OPCM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014058 49856 WRAP73 http://www.ncbi.nlm.nih.gov/gene/?term=49856 WDR8 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014059 49856 WRAP73 http://www.ncbi.nlm.nih.gov/gene/?term=49856 WDR8 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014060 49895 CG17018 http://www.ncbi.nlm.nih.gov/gene/?term=49895 "Dmel_ BcDNA:RE40762, CG17410, Dmel\CG17018 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00014061 498 ATP5A1 http://www.ncbi.nlm.nih.gov/gene/?term=498 "ATP5A, ATP5AL2, ATPM, COXPD22, HEL-S-123m, MC5DN4, MOM2, OMR, ORM, hATP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014062 49953 GCS2alpha http://www.ncbi.nlm.nih.gov/gene/?term=49953 "Dmel_CG14476, BcDNA:GH04962, CG14476, Dmel\CG14476, clot#312 " mRNA Drosophila melanogaster 25838129 Basal Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00014063 4998 ORC1 http://www.ncbi.nlm.nih.gov/gene/?term=4998 "HSORC1L, PARC1, ORC1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014064 4998 ORC1 http://www.ncbi.nlm.nih.gov/gene/?term=4998 "HSORC1L, PARC1, ORC1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014065 4998 ORC1 http://www.ncbi.nlm.nih.gov/gene/?term=4998 "HSORC1L, PARC1, ORC1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014066 4998 ORC1 http://www.ncbi.nlm.nih.gov/gene/?term=4998 "HSORC1, ORC1L, PARC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014067 4999 ORC2 http://www.ncbi.nlm.nih.gov/gene/?term=4999 ORC2L mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014068 5000 ORC4 http://www.ncbi.nlm.nih.gov/gene/?term=5000 "ORC4LP, ORC4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014069 5001 ORC5 http://www.ncbi.nlm.nih.gov/gene/?term=5001 "ORC5LP, ORC5T, PPP1R117, ORC5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014070 5002 SLC22A18 http://www.ncbi.nlm.nih.gov/gene/?term=5002 "BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, SLC22A1L, TSSC5, p45-BWR1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014071 5002 SLC22A18 http://www.ncbi.nlm.nih.gov/gene/?term=5002 "BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, SLC22A1L, TSSC5, p45-BWR1A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014072 5007 OSBP http://www.ncbi.nlm.nih.gov/gene/?term=5007 OSBP1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014073 5007 OSBP http://www.ncbi.nlm.nih.gov/gene/?term=5007 OSBP1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014074 5007 OSBP http://www.ncbi.nlm.nih.gov/gene/?term=5007 OSBP1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014075 5010 CLDN11 http://www.ncbi.nlm.nih.gov/gene/?term=5010 "OSP, OTM " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014076 5013355 GSPATT00030812001 http://www.ncbi.nlm.nih.gov/gene/?term=5013355 GSPATT00030812001 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00014077 5018 OXA1L http://www.ncbi.nlm.nih.gov/gene/?term=5018 OXA1 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014078 5018 OXA1L http://www.ncbi.nlm.nih.gov/gene/?term=5018 OXA1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014079 5019 OXCT1 http://www.ncbi.nlm.nih.gov/gene/?term=5019 "OXCT, SCOT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014080 50250 CG14767 http://www.ncbi.nlm.nih.gov/gene/?term=50250 "Dmel_ CG8575, Dmel\CG14767, dmCG14767 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00014081 5025 P2RX4 http://www.ncbi.nlm.nih.gov/gene/?term=5025 "P2X4, P2X4R " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014082 5026 P2RX5 http://www.ncbi.nlm.nih.gov/gene/?term=5026 "LRH-1, P2X5, P2X5R " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014083 5027 P2RX7 http://www.ncbi.nlm.nih.gov/gene/?term=5027 P2X7 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014084 5028 P2RY1 http://www.ncbi.nlm.nih.gov/gene/?term=5028 P2Y1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014085 50296 dpr6 http://www.ncbi.nlm.nih.gov/gene/?term=50296 "Dmel_CG14162, BcDNA:LD13525, CG14162, Dmel\CG14162, Dpr-6, Dpr6 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00014086 50296 dpr6 http://www.ncbi.nlm.nih.gov/gene/?term=50296 "Dmel_CG14162, BcDNA:LD13525, CG14162, Dmel\CG14162, Dpr-6, Dpr6 " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00014087 5033 P4HA1 http://www.ncbi.nlm.nih.gov/gene/?term=5033 P4HA mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00014088 5033 P4HA1 http://www.ncbi.nlm.nih.gov/gene/?term=5033 P4HA mRNA Homo sapiens 25753659 Ribosome HT1080 cell qRT-PCR Figure S1: Polysomal gradient analysis. HT1080 cells were incubated under control (21% oxygen) or hypoxic (1% oxygen) conditions for up to 36 h as described in Figure 1. Shown are representative original RT-PCR data (30 cycles for beta-Actin and the external standard [extSt]; 35 cycles for the other genes) from pooled samples to visualize mRNA distribution following fractionation of sucrose gradients at control conditions (C) and 36 h of hypoxia (Hy). The external standard (a synthetic in vitro transcript) was diluted to appropriate concentration for qPCR and added directly after gradient fractionation and prior to RNA isolation as a technical control. The external standard served for fraction dependent normalization. RLID00014089 5033 P4HA1 http://www.ncbi.nlm.nih.gov/gene/?term=5033 P4HA mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014090 5034 P4HB http://www.ncbi.nlm.nih.gov/gene/?term=5034 "CLCRP1, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014091 5034 P4HB http://www.ncbi.nlm.nih.gov/gene/?term=5034 "CLCRP1, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014092 5034 P4HB http://www.ncbi.nlm.nih.gov/gene/?term=5034 "CLCRP1, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014093 5034 P4HB http://www.ncbi.nlm.nih.gov/gene/?term=5034 "CLCRP1, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014094 5034 P4HB http://www.ncbi.nlm.nih.gov/gene/?term=5034 "CLCRP1, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB " mRNA Homo sapiens 25753659 Ribosome HT1080 cell qRT-PCR Figure S1: Polysomal gradient analysis. HT1080 cells were incubated under control (21% oxygen) or hypoxic (1% oxygen) conditions for up to 36 h as described in Figure 1. Shown are representative original RT-PCR data (30 cycles for beta-Actin and the external standard [extSt]; 35 cycles for the other genes) from pooled samples to visualize mRNA distribution following fractionation of sucrose gradients at control conditions (C) and 36 h of hypoxia (Hy). The external standard (a synthetic in vitro transcript) was diluted to appropriate concentration for qPCR and added directly after gradient fractionation and prior to RNA isolation as a technical control. The external standard served for fraction dependent normalization. RLID00014095 5034 P4HB http://www.ncbi.nlm.nih.gov/gene/?term=5034 "CLCRP1, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014096 503550 Klri1 http://www.ncbi.nlm.nih.gov/gene/?term=503550 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014097 503582 ARGFX http://www.ncbi.nlm.nih.gov/gene/?term=503582 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014098 503582 ARGFX http://www.ncbi.nlm.nih.gov/gene/?term=503582 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014099 503693 LOH12CR2 http://www.ncbi.nlm.nih.gov/gene/?term=503693 LOH2CR12 lncRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00014100 5036 PA2G4 http://www.ncbi.nlm.nih.gov/gene/?term=5036 "EBP1, HG4-1, p38-2G4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014101 5036 PA2G4 http://www.ncbi.nlm.nih.gov/gene/?term=5036 "EBP1, HG4-1, p38-2G4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014102 5036 PA2G4 http://www.ncbi.nlm.nih.gov/gene/?term=5036 "EBP1, HG4-1, p38-2G4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014103 5037 PEBP1 http://www.ncbi.nlm.nih.gov/gene/?term=5037 "HCNP, HCNPpp, HEL-210, HEL-S-34, HEL-S-96, PBP, PEBP, PEBP-1, RKIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014104 5037 PEBP1 http://www.ncbi.nlm.nih.gov/gene/?term=5037 "HCNP, HCNPpp, HEL-210, HEL-S-34, HEL-S-96, PBP, PEBP, PEBP-1, RKIP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014105 5037 PEBP1 http://www.ncbi.nlm.nih.gov/gene/?term=5037 "HCNP, HCNPpp, HEL-210, HEL-S-34, HEL-S-96, PBP, PEBP, PEBP-1, RKIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014106 503835 DUXA http://www.ncbi.nlm.nih.gov/gene/?term=503835 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014107 503835 DUXA http://www.ncbi.nlm.nih.gov/gene/?term=503835 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014108 5042 PABPC3 http://www.ncbi.nlm.nih.gov/gene/?term=5042 "PABP3, PABPL3, tPABP " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014109 5042 PABPC3 http://www.ncbi.nlm.nih.gov/gene/?term=5042 "PABP3, PABPL3, tPABP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014110 5045 FURIN http://www.ncbi.nlm.nih.gov/gene/?term=5045 "FUR, PACE, PCSK3, SPC1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014111 5045 FURIN http://www.ncbi.nlm.nih.gov/gene/?term=5045 "FUR, PACE, PCSK3, SPC1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014112 5046 PCSK6 http://www.ncbi.nlm.nih.gov/gene/?term=5046 "PACE4, SPC4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014113 50484 RRM2B http://www.ncbi.nlm.nih.gov/gene/?term=50484 "MTDPS8A, MTDPS8B, P53R2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014114 50484 RRM2B http://www.ncbi.nlm.nih.gov/gene/?term=50484 "MTDPS8A, MTDPS8B, P53R2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014115 50487 PLA2G3 http://www.ncbi.nlm.nih.gov/gene/?term=50487 "GIII-SPLA2, SPLA2III, sPLA2-III " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014116 50488 MINK1 http://www.ncbi.nlm.nih.gov/gene/?term=50488 "B55, MAP4K6, MINK, YSK2, ZC3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014117 50488 MINK1 http://www.ncbi.nlm.nih.gov/gene/?term=50488 "B55, MAP4K6, MINK, YSK2, ZC3, hMINK, hMINKbeta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014118 5048 PAFAH1B1 http://www.ncbi.nlm.nih.gov/gene/?term=5048 "LIS1, LIS2, MDCR, MDS, PAFAH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014119 5048 PAFAH1B1 http://www.ncbi.nlm.nih.gov/gene/?term=5048 "LIS1, LIS2, MDCR, MDS, PAFAH " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014120 5048 PAFAH1B1 http://www.ncbi.nlm.nih.gov/gene/?term=5048 "LIS1, LIS2, MDCR, MDS, PAFAH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014121 50492 Thop1 http://www.ncbi.nlm.nih.gov/gene/?term=50492 "AI131655, AI327041, EP24.15 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014122 50493 Txnrd1 http://www.ncbi.nlm.nih.gov/gene/?term=50493 "TR, TR1, TrxR1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014123 50496 E2f6 http://www.ncbi.nlm.nih.gov/gene/?term=50496 "AI462434, E2F6b, EMA " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014124 50497 Hspa14 http://www.ncbi.nlm.nih.gov/gene/?term=50497 "70kDa, HSP70L1, Hsp70-4, NST-1, hsr.1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014125 5049 PAFAH1B2 http://www.ncbi.nlm.nih.gov/gene/?term=5049 HEL-S-303 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014126 5049 PAFAH1B2 http://www.ncbi.nlm.nih.gov/gene/?term=5049 HEL-S-303 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014127 5049 PAFAH1B2 http://www.ncbi.nlm.nih.gov/gene/?term=5049 HEL-S-303 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014128 50507 NOX4 http://www.ncbi.nlm.nih.gov/gene/?term=50507 "KOX, KOX-1, RENOX " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00014129 5050 PAFAH1B3 http://www.ncbi.nlm.nih.gov/gene/?term=5050 PAFAHG mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014130 5050 PAFAH1B3 http://www.ncbi.nlm.nih.gov/gene/?term=5050 PAFAHG mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014131 50518 a http://www.ncbi.nlm.nih.gov/gene/?term=50518 "A, ASIP, ASP, As " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00014132 5051 PAFAH2 http://www.ncbi.nlm.nih.gov/gene/?term=5051 HSD-PLA2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014133 50523 Lats2 http://www.ncbi.nlm.nih.gov/gene/?term=50523 "4932411G09Rik, AV277261, AW228608 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00014134 50525 Spag6 http://www.ncbi.nlm.nih.gov/gene/?term=50525 PF16 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014135 50527 Ero1l http://www.ncbi.nlm.nih.gov/gene/?term=50527 "ERO1-L, Ero1a " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00014136 5052 PRDX1 http://www.ncbi.nlm.nih.gov/gene/?term=5052 "MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014137 5052 PRDX1 http://www.ncbi.nlm.nih.gov/gene/?term=5052 "MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014138 5052 PRDX1 http://www.ncbi.nlm.nih.gov/gene/?term=5052 "MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014139 5054 SERPINE1 http://www.ncbi.nlm.nih.gov/gene/?term=5054 "PAI, PAI-1, PAI1, PLANH1 " mRNA Homo sapiens 19175411 Ribosome T-cell|SeAx qRT-PCR "Using quantitative real-time RT-PCR we evaluated, whether mRNAs coding for differently located proteins are selectively enriched in one of the two analysed compartments, namely free versus membrane-associated polysomes. We selected genes coding for proteins located in the plasma membrane (GPR137B), secreted proteins (TIC2, IBP2, PAI) and cytosolic proteins (the house keeping genes GAPDH and HMBS). In fact, the distribution of the specific mRNA was as predicted ( Fig. 1): The average ratio of specific mRNA at bound ribosomes versus free ribosomes was 1 ? 4.4 for the housekeeping genes (GAPDH and HMBS) and 13.3 ? 1 for genes coding for membrane-bound or secreted proteins. Ratios for genes coding for cytosolic proteins were always below 0.6 and those for membrane or secreted genes were always above 1. The highest values were observed for PAI in MyLa (57 ? 1) and GPR137B in SeAx (34 ? 1), while the lowest ratios were detected for HMBS (1 ? 55) and GAPDH (1 ? 12) in HuT78. " RLID00014140 5058 PAK1 http://www.ncbi.nlm.nih.gov/gene/?term=5058 PAKalpha mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014141 5058 PAK1 http://www.ncbi.nlm.nih.gov/gene/?term=5058 PAKalpha mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014142 50592 Gria1 http://www.ncbi.nlm.nih.gov/gene/?term=50592 "GluA1, gluR-A " mRNA Rattus norvegicus 19073915 Dendrite Hippocampus In situ hybridization "We found that RARa protein co-immunoprecipitated with GluR1 mRNA as well as mRNAs encoding GluR2 and eukaryotic elongation factor 2 (eEF2), all of which have been shown to be dendritically localized by in situ hybridization " RLID00014143 50592 Gria1 http://www.ncbi.nlm.nih.gov/gene/?term=50592 "GluA1, gluR-A " mRNA Rattus norvegicus 23166306 Dendrite Cortical cultures In situ hybridization The hybridization signals of GluA1 and GluA2 mRNAs were present in both the cell soma and dendrites of cultured cortical cells immunolabeled with a specific marker for Microtubule-Associated Protein-2 a (MAP2a). RLID00014144 50592 Gria1 http://www.ncbi.nlm.nih.gov/gene/?term=50592 "GluA1, gluR-A " mRNA Rattus norvegicus 23296627 Dendrite Pyramidal cell Fluorescence in situ hybridization "GluA1-4 subunit mRNAs were highly localized to the apical dendrites of pyramidal cells, whereas in interneurons they were present in multiple dendrites. In contrast, in the dentate gyrus, GluA1-4 subunit mRNAs were virtually restricted to the somata and were absent from the dendrites of granule cells. " RLID00014145 50592 Gria1 http://www.ncbi.nlm.nih.gov/gene/?term=50592 "GluA1, gluR-A " mRNA Rattus norvegicus 16899729 Dendrite Hippocampus Northern blot "Using quantitative high-resolution in situ hybridization, we show that mRNAs encoding the AMPA-type glutamate receptor subunits (GluRs) 1 and 2 are localized to dendrites of hippocampal neurons and are regulated by paradigms that alter synaptic efficacy. " RLID00014146 50592 Gria1 http://www.ncbi.nlm.nih.gov/gene/?term=50592 "GluA1, gluR-A " mRNA Rattus norvegicus 23166306 Cell body Cortical cultures In situ hybridization "In vivo, GluA1 and GluA2 mRNAs showed a strong signal in the cell bodies across hippocampal and cortical regions, together with the presence of a clear signal in the proximal dendrites. " RLID00014147 50614 GALNT9 http://www.ncbi.nlm.nih.gov/gene/?term=50614 "GALNAC-T9, GALNACT9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014148 50618 ITSN2 http://www.ncbi.nlm.nih.gov/gene/?term=50618 "PRO2015, SH3D1B, SH3P18, SWA, SWAP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014149 50618 ITSN2 http://www.ncbi.nlm.nih.gov/gene/?term=50618 "PRO2015, SH3D1B, SH3P18, SWA, SWAP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014150 50618 ITSN2 http://www.ncbi.nlm.nih.gov/gene/?term=50618 "PRO2015, SH3D1B, SH3P18, SWA, SWAP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014151 50619 DEF6 http://www.ncbi.nlm.nih.gov/gene/?term=50619 "IBP, SLAT, SWAP70L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014152 50619 DEF6 http://www.ncbi.nlm.nih.gov/gene/?term=50619 "IBP, SLAT, SWAP70L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014153 50626 CYHR1 http://www.ncbi.nlm.nih.gov/gene/?term=50626 CHRP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014154 50628 GEMIN4 http://www.ncbi.nlm.nih.gov/gene/?term=50628 "HC56, HCAP1, HHRF-1, p97 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014155 50628 GEMIN4 http://www.ncbi.nlm.nih.gov/gene/?term=50628 "HC56, HCAP1, HHRF-1, p97 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014156 50628 GEMIN4 http://www.ncbi.nlm.nih.gov/gene/?term=50628 "HC56, HCAP1, HHRF-1, p97 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014157 5062 PAK2 http://www.ncbi.nlm.nih.gov/gene/?term=5062 "PAK65, PAKgamma " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014158 5062 PAK2 http://www.ncbi.nlm.nih.gov/gene/?term=5062 "PAK65, PAKgamma " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014159 5062 PAK2 http://www.ncbi.nlm.nih.gov/gene/?term=5062 "PAK65, PAKgamma " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014160 50640 PNPLA8 http://www.ncbi.nlm.nih.gov/gene/?term=50640 "IPLA2-2, IPLA2G, MMLA, PNPLA-gamma, iPLA2gamma " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014161 50640 PNPLA8 http://www.ncbi.nlm.nih.gov/gene/?term=50640 "IPLA2-2, IPLA2G, MMLA, PNPLA-gamma, iPLA2gamma " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014162 5064 PALM http://www.ncbi.nlm.nih.gov/gene/?term=5064 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014163 50650 ARHGEF3 http://www.ncbi.nlm.nih.gov/gene/?term=50650 "GEF3, STA3, XPLN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014164 5066 PAM http://www.ncbi.nlm.nih.gov/gene/?term=5066 "PAL, PHM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014165 5066 PAM http://www.ncbi.nlm.nih.gov/gene/?term=5066 "PAL, PHM " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014166 5066 PAM http://www.ncbi.nlm.nih.gov/gene/?term=5066 "PAL, PHM " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00014167 50686 Gsk3a http://www.ncbi.nlm.nih.gov/gene/?term=50686 mRNA Rattus norvegicus 24898526 Axon Spinal motoneuron In situ hybridization|qRT-PCR "In cultured cortical neurons which do not store glycogen but nevertheless express glycogen synthase, the GS mRNA is also subject to axonal and dendritic localization. In spinal motoneurons and trigeminal neurons in situ, however, the mRNAs could only be demonstrated in the neuronal somata but not in the nerves. " RLID00014168 50686 Gsk3a http://www.ncbi.nlm.nih.gov/gene/?term=50686 mRNA Rattus norvegicus 24898526 Dendrite Spinal motoneuron In situ hybridization|qRT-PCR "In cultured cortical neurons which do not store glycogen but nevertheless express glycogen synthase, the GS mRNA is also subject to axonal and dendritic localization. In spinal motoneurons and trigeminal neurons in situ, however, the mRNAs could only be demonstrated in the neuronal somata but not in the nerves. " RLID00014169 5069 PAPPA http://www.ncbi.nlm.nih.gov/gene/?term=5069 "ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014170 506 ATP5B http://www.ncbi.nlm.nih.gov/gene/?term=506 "ATPMB, ATPSB, HEL-S-271 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014171 506 ATP5B http://www.ncbi.nlm.nih.gov/gene/?term=506 "ATPMB, ATPSB, HEL-S-271 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014172 50717 DCAF8 http://www.ncbi.nlm.nih.gov/gene/?term=50717 "GAN2, H326, WDR42A " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014173 50717 DCAF8 http://www.ncbi.nlm.nih.gov/gene/?term=50717 "GAN2, H326, WDR42A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014174 50720 Sacs http://www.ncbi.nlm.nih.gov/gene/?term=50720 "A230052M14, DNAJC29, E130115J16Rik, mKIAA0730 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014175 50721 Sirt6 http://www.ncbi.nlm.nih.gov/gene/?term=50721 "2810449N18Rik, AI043036, Sir2l6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014176 5073 PARN http://www.ncbi.nlm.nih.gov/gene/?term=5073 "DAN, DKCB6, PFBMFT4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014177 5074 PAWR http://www.ncbi.nlm.nih.gov/gene/?term=5074 "PAR4, Par-4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014178 50753 Fbxo8 http://www.ncbi.nlm.nih.gov/gene/?term=50753 Fbx8 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014179 50754 Fbxw7 http://www.ncbi.nlm.nih.gov/gene/?term=50754 "1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014180 50766 Crim1 http://www.ncbi.nlm.nih.gov/gene/?term=50766 AU015004 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014181 50767 Pnpla6 http://www.ncbi.nlm.nih.gov/gene/?term=50767 "AI661849, MSws, Nte " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014182 5076 PAX2 http://www.ncbi.nlm.nih.gov/gene/?term=5076 "FSGS7, PAPRS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014183 50771 Atp9b http://www.ncbi.nlm.nih.gov/gene/?term=50771 "AA934181, Atpc2b, IIb, MMR " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014184 50772 Mapk6 http://www.ncbi.nlm.nih.gov/gene/?term=50772 "2610021I23Rik, D130053K17Rik, Erk3, Mapk43, Prkm4, Prkm6, Mapk6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014185 50781 Dkk3 http://www.ncbi.nlm.nih.gov/gene/?term=50781 "AW061014, C87148 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014186 50788 Fbxl8 http://www.ncbi.nlm.nih.gov/gene/?term=50788 FBL8 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014187 50790 Acsl4 http://www.ncbi.nlm.nih.gov/gene/?term=50790 "9430020A05Rik, ACS4, AU018108, Facl4, Lacs4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014188 50793 Orc3 http://www.ncbi.nlm.nih.gov/gene/?term=50793 Orc3l mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014189 50796 Dmrt1 http://www.ncbi.nlm.nih.gov/gene/?term=50796 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014190 50797 Copb2 http://www.ncbi.nlm.nih.gov/gene/?term=50797 AI256832 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014191 50804 MYEF2 http://www.ncbi.nlm.nih.gov/gene/?term=50804 "HsT18564, MEF-2, MST156, MSTP156, myEF-2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014192 50804 MYEF2 http://www.ncbi.nlm.nih.gov/gene/?term=50804 "HsT18564, MEF-2, MST156, MSTP156, myEF-2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014193 50807 ASAP1 http://www.ncbi.nlm.nih.gov/gene/?term=50807 "AMAP1, CENTB4, DDEF1, PAG2, PAP, ZG14P " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014194 50807 ASAP1 http://www.ncbi.nlm.nih.gov/gene/?term=50807 "AMAP1, CENTB4, DDEF1, PAG2, PAP, ZG14P " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014195 50807 ASAP1 http://www.ncbi.nlm.nih.gov/gene/?term=50807 "AMAP1, CENTB4, DDEF1, PAG2, PAP, ZG14P " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014196 50807 ASAP1 http://www.ncbi.nlm.nih.gov/gene/?term=50807 "AMAP1, CENTB4, DDEF1, PAG2, PAP, ZG14P " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014197 50808 AK3 http://www.ncbi.nlm.nih.gov/gene/?term=50808 "AK3L1, AK6, AKL3L, AKL3L1, FIX " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014198 50808 AK3 http://www.ncbi.nlm.nih.gov/gene/?term=50808 "AK3L1, AK6, AKL3L, AKL3L1, FIX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014199 50809 HP1BP3 http://www.ncbi.nlm.nih.gov/gene/?term=50809 "HP1-BP74, HP1BP74 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014200 50809 HP1BP3 http://www.ncbi.nlm.nih.gov/gene/?term=50809 "HP1-BP74, HP1BP74 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014201 5080 PAX6 http://www.ncbi.nlm.nih.gov/gene/?term=5080 "AN, AN2, D11S812E, FVH1, MGDA, WAGR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014202 50810 HDGFRP3 http://www.ncbi.nlm.nih.gov/gene/?term=50810 "CGI-142, HDGF-2, HDGF2, HRP-3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014203 50813 COPS7A http://www.ncbi.nlm.nih.gov/gene/?term=50813 "CSN7, CSN7A, SGN7a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014204 50814 NSDHL http://www.ncbi.nlm.nih.gov/gene/?term=50814 "H105E3, SDR31E1, XAP104 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014205 50814 NSDHL http://www.ncbi.nlm.nih.gov/gene/?term=50814 "H105E3, SDR31E1, XAP104 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014206 5082 PDCL http://www.ncbi.nlm.nih.gov/gene/?term=5082 PhLP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014207 5082 PDCL http://www.ncbi.nlm.nih.gov/gene/?term=5082 PhLP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014208 50848 F11R http://www.ncbi.nlm.nih.gov/gene/?term=50848 "CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014209 50848 F11R http://www.ncbi.nlm.nih.gov/gene/?term=50848 "CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014210 50848 F11R http://www.ncbi.nlm.nih.gov/gene/?term=50848 "CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014211 50848 F11R http://www.ncbi.nlm.nih.gov/gene/?term=50848 "CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014212 50850 Spast http://www.ncbi.nlm.nih.gov/gene/?term=50850 "Spg4, mKIAA1083 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014213 50854 C6orf48 http://www.ncbi.nlm.nih.gov/gene/?term=50854 "D6S57, G8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014214 50854 C6orf48 http://www.ncbi.nlm.nih.gov/gene/?term=50854 "D6S57, G8 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014215 50854 C6orf48 http://www.ncbi.nlm.nih.gov/gene/?term=50854 "D6S57, G8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014216 50855 PARD6A http://www.ncbi.nlm.nih.gov/gene/?term=50855 "PAR-6A, PAR6, PAR6C, PAR6alpha, TAX40, TIP-40 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014217 50855 PARD6A http://www.ncbi.nlm.nih.gov/gene/?term=50855 "PAR-6A, PAR6, PAR6C, PAR6alpha, TAX40, TIP-40 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014218 50862 RNF141 http://www.ncbi.nlm.nih.gov/gene/?term=50862 "ZFP26, ZNF230 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014219 50862 RNF141 http://www.ncbi.nlm.nih.gov/gene/?term=50862 "ZFP26, ZNF230 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014220 50863 NTM http://www.ncbi.nlm.nih.gov/gene/?term=50863 "HNT, IGLON2, NTRI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014221 50865 HEBP1 http://www.ncbi.nlm.nih.gov/gene/?term=50865 "HBP, HEBP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014222 50865 HEBP1 http://www.ncbi.nlm.nih.gov/gene/?term=50865 "HBP, HEBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014223 50868 Keap1 http://www.ncbi.nlm.nih.gov/gene/?term=50868 "INRF2, mKIAA0132 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014224 50873 Park2 http://www.ncbi.nlm.nih.gov/gene/?term=50873 PRKN mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014225 50874 Tmod4 http://www.ncbi.nlm.nih.gov/gene/?term=50874 "MTMOD, Sk-Tmod " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014226 50875 Tmod3 http://www.ncbi.nlm.nih.gov/gene/?term=50875 "U-Tmod, UTMOD " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014227 50875 Tmod3 http://www.ncbi.nlm.nih.gov/gene/?term=50875 "U-Tmod, UTMOD " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014228 50876 Tmod2 http://www.ncbi.nlm.nih.gov/gene/?term=50876 "N-Tmod, NTMOD " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014229 5087 PBX1 http://www.ncbi.nlm.nih.gov/gene/?term=5087 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014230 50884 Nckap1 http://www.ncbi.nlm.nih.gov/gene/?term=50884 "C79304, H19, Hem-2, Hem2, Nap1, mKIAA0587, mh19, p125Nap1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014231 50887 Hmgn5 http://www.ncbi.nlm.nih.gov/gene/?term=50887 "GARP45, NBP-45, Nsbp1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014232 50887 Hmgn5 http://www.ncbi.nlm.nih.gov/gene/?term=50887 "GARP45, NBP-45, Nsbp1 " mRNA Mus musculus 25825524 Growth cone N1E-115 cell Fluorescence in situ hybridization "Fluorescent in situ hybridization (FISH) with riboprobes antisense to Hmgn5 mRNA showed that Hmgn5 mRNA localizes to bright punctate structures in the growth cones of N1E-115 cells, similarly to other known localized mRNAs (4, 9). " RLID00014233 5089 PBX2 http://www.ncbi.nlm.nih.gov/gene/?term=5089 "G17, HOX12MHC, PBX2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014234 5089 PBX2 http://www.ncbi.nlm.nih.gov/gene/?term=5089 "G17, HOX12, PBX2MHC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014235 50908 C1s1 http://www.ncbi.nlm.nih.gov/gene/?term=50908 "AA959438, AI255193, AI327365, C1s, C1sa " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014236 50911 Exosc9 http://www.ncbi.nlm.nih.gov/gene/?term=50911 "PM/Scl-75, Pmscl1, RRP45, p5, p6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014237 5091 PC http://www.ncbi.nlm.nih.gov/gene/?term=5091 PCB mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014238 50926 Hnrnpdl http://www.ncbi.nlm.nih.gov/gene/?term=50926 "AA407431, AA959857, D5Ertd650e, D5Wsu145e1, Hnrpdl, JKTBP, hnRNP DL, hnRNP-DL, Hnrnpdl " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014239 50928 Klrg1 http://www.ncbi.nlm.nih.gov/gene/?term=50928 "2F1-Ag, MAFA, MAFA-L " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00014240 5092 PCBD1 http://www.ncbi.nlm.nih.gov/gene/?term=5092 "DCOH, PCBD, PCD, PHS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014241 5092 PCBD1 http://www.ncbi.nlm.nih.gov/gene/?term=5092 "DCOH, PCBD, PCD, PHS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014242 5092 PCBD1 http://www.ncbi.nlm.nih.gov/gene/?term=5092 "DCOH, PCBD, PCD, PHS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014243 50933 Uchl3 http://www.ncbi.nlm.nih.gov/gene/?term=50933 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014244 50937 CDON http://www.ncbi.nlm.nih.gov/gene/?term=50937 "CDO1, HPE11, ORCAM, CDON " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014245 50937 CDON http://www.ncbi.nlm.nih.gov/gene/?term=50937 "CDO1, HPE11, ORCAM, CDON " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014246 5093 PCBP1 http://www.ncbi.nlm.nih.gov/gene/?term=5093 "HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014247 5093 PCBP1 http://www.ncbi.nlm.nih.gov/gene/?term=5093 "HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014248 5093 PCBP1 http://www.ncbi.nlm.nih.gov/gene/?term=5093 "HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014249 50940 PDE11A http://www.ncbi.nlm.nih.gov/gene/?term=50940 PPNAD2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014250 50940 PDE11A http://www.ncbi.nlm.nih.gov/gene/?term=50940 PPNAD2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014251 50940 PDE11A http://www.ncbi.nlm.nih.gov/gene/?term=50940 PPNAD2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014252 5094 PCBP2 http://www.ncbi.nlm.nih.gov/gene/?term=5094 "HNRNPE2, HNRPE2, hnRNP-E2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014253 5094 PCBP2 http://www.ncbi.nlm.nih.gov/gene/?term=5094 "HNRNPE2, HNRPE2, hnRNP-E2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014254 5094 PCBP2 http://www.ncbi.nlm.nih.gov/gene/?term=5094 "HNRNPE2, HNRPE2, hnRNP-E2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014255 5095 PCCA http://www.ncbi.nlm.nih.gov/gene/?term=5095 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014256 5096 PCCB http://www.ncbi.nlm.nih.gov/gene/?term=5096 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014257 5096 PCCB http://www.ncbi.nlm.nih.gov/gene/?term=5096 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014258 5097 PCDH1 http://www.ncbi.nlm.nih.gov/gene/?term=5097 "PC42, PCDH42 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014259 5097 PCDH1 http://www.ncbi.nlm.nih.gov/gene/?term=5097 "PC42, PCDH42 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014260 5098 PCDHGC3 http://www.ncbi.nlm.nih.gov/gene/?term=5098 "PC43, PCDH-GAMMA-C3, PCDH2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014261 50995 Uba2 http://www.ncbi.nlm.nih.gov/gene/?term=50995 "AA986091, Arx, Sae2, UBA1, Ubl1a2, Uble1b " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014262 50997 Mpp2 http://www.ncbi.nlm.nih.gov/gene/?term=50997 "D11Bwg0652e, Dlg2, Dlgh2, Pals4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014263 50999 TMED5 http://www.ncbi.nlm.nih.gov/gene/?term=50999 "CGI-100, p24g2, p28 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014264 50999 TMED5 http://www.ncbi.nlm.nih.gov/gene/?term=50999 "CGI-100, p24g2, p28 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014265 50999 TMED5 http://www.ncbi.nlm.nih.gov/gene/?term=50999 "CGI-100, p24g2, p28 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014266 5099 PCDH7 http://www.ncbi.nlm.nih.gov/gene/?term=5099 "BH-Pcdh, BHPCDH, PPP1R120 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014267 509 ATP5C1 http://www.ncbi.nlm.nih.gov/gene/?term=509 "ATP5C, ATP5CL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014268 509 ATP5C1 http://www.ncbi.nlm.nih.gov/gene/?term=509 "ATP5C, ATP5CL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014269 51000 SLC35B3 http://www.ncbi.nlm.nih.gov/gene/?term=51000 "C6orf196, CGI-19, PAPST2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014270 51002 TPRKB http://www.ncbi.nlm.nih.gov/gene/?term=51002 CGI-121 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014271 51002 TPRKB http://www.ncbi.nlm.nih.gov/gene/?term=51002 CGI-121 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014272 51002 TPRKB http://www.ncbi.nlm.nih.gov/gene/?term=51002 CGI-121 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014273 51003 MED31 http://www.ncbi.nlm.nih.gov/gene/?term=51003 "3110004H13Rik, CGI-125, Soh1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014274 51004 COQ6 http://www.ncbi.nlm.nih.gov/gene/?term=51004 "CGI-10, CGI10, COQ10D6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014275 51004 COQ6 http://www.ncbi.nlm.nih.gov/gene/?term=51004 "CGI-10, CGI10, COQ10D6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014276 51005 AMDHD2 http://www.ncbi.nlm.nih.gov/gene/?term=51005 CGI-14 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014277 5100 PCDH8 http://www.ncbi.nlm.nih.gov/gene/?term=5100 "ARCADLIN, PAPC " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014278 51010 EXOSC3 http://www.ncbi.nlm.nih.gov/gene/?term=51010 "CGI-102, PCH1B, RRP40, Rrp40p, bA3J10.7, hRrp-40, p10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014279 51010 EXOSC3 http://www.ncbi.nlm.nih.gov/gene/?term=51010 "CGI-102, PCH1B, RRP40, Rrp40p, bA3J10.7, hRrp-40, p10 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014280 51010 EXOSC3 http://www.ncbi.nlm.nih.gov/gene/?term=51010 "CGI-102, PCH1B, RRP40, Rrp40p, bA3J10.7, hRrp-40, p10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014281 51011 FAHD2A http://www.ncbi.nlm.nih.gov/gene/?term=51011 CGI-105 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014282 51013 EXOSC1 http://www.ncbi.nlm.nih.gov/gene/?term=51013 "CGI-108, CSL4, Csl4p, SKI4, Ski4p, p13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014283 51014 TMED7 http://www.ncbi.nlm.nih.gov/gene/?term=51014 "CGI-109, p24g3, p24gamma3, p27 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014284 51014 TMED7 http://www.ncbi.nlm.nih.gov/gene/?term=51014 "CGI-109, p24g3, p24gamma3, p27 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014285 51014 TMED7 http://www.ncbi.nlm.nih.gov/gene/?term=51014 "CGI-109, p24g3, p24gamma3, p27 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014286 51015 ISOC1 http://www.ncbi.nlm.nih.gov/gene/?term=51015 CGI-111 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014287 51015 ISOC1 http://www.ncbi.nlm.nih.gov/gene/?term=51015 CGI-111 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014288 51016 EMC9 http://www.ncbi.nlm.nih.gov/gene/?term=51016 "C14orf122, CGI-112, FAM158A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014289 51016 EMC9 http://www.ncbi.nlm.nih.gov/gene/?term=51016 "C14orf122, CGI-112, FAM158A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014290 51018 RRP15 http://www.ncbi.nlm.nih.gov/gene/?term=51018 "CGI-115, KIAA0507 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014291 51018 RRP15 http://www.ncbi.nlm.nih.gov/gene/?term=51018 "CGI-115, KIAA0507 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014292 51018 RRP15 http://www.ncbi.nlm.nih.gov/gene/?term=51018 "CGI-115, KIAA0507 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014293 51018 RRP15 http://www.ncbi.nlm.nih.gov/gene/?term=51018 "CGI-115, KIAA0507 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014294 51019 CCDC53 http://www.ncbi.nlm.nih.gov/gene/?term=51019 CGI-116 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014295 5101 PCDH9 http://www.ncbi.nlm.nih.gov/gene/?term=5101 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014296 51020 HDDC2 http://www.ncbi.nlm.nih.gov/gene/?term=51020 "C6orf74, CGI-130, NS5ATP2, dJ167O5.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014297 51021 MRPS16 http://www.ncbi.nlm.nih.gov/gene/?term=51021 "CGI-132, COXPD2, MRP-S16, RPMS16 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014298 51021 MRPS16 http://www.ncbi.nlm.nih.gov/gene/?term=51021 "CGI-132, COXPD2, MRP-S16, RPMS16 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014299 51021 MRPS16 http://www.ncbi.nlm.nih.gov/gene/?term=51021 "CGI-132, COXPD2, MRP-S16, RPMS16 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014300 51022 GLRX2 http://www.ncbi.nlm.nih.gov/gene/?term=51022 "CGI-133, GRX2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014301 51023 MRPS18C http://www.ncbi.nlm.nih.gov/gene/?term=51023 "CGI-134, MRP-S18-1, MRP-S18-c, MRPS18-1, S18mt-c, mrps18-c " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014302 51023 MRPS18C http://www.ncbi.nlm.nih.gov/gene/?term=51023 "CGI-134, MRP-S18-1, MRP-S18-c, MRPS18-1, S18mt-c, mrps18-c " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014303 51024 FIS1 http://www.ncbi.nlm.nih.gov/gene/?term=51024 "CGI-135, TTC11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014304 51024 FIS1 http://www.ncbi.nlm.nih.gov/gene/?term=51024 "CGI-135, TTC11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014305 51025 PAM16 http://www.ncbi.nlm.nih.gov/gene/?term=51025 "CGI-136, MAGMAS, SMDMDM, TIM16, TIMM16 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014306 51026 GOLT1B http://www.ncbi.nlm.nih.gov/gene/?term=51026 "CGI-141, GCT2, GOT1, GOT1B, YMR292W " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014307 51026 GOLT1B http://www.ncbi.nlm.nih.gov/gene/?term=51026 "CGI-141, GCT2, GOT1, GOT1B, YMR292W " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014308 51026 GOLT1B http://www.ncbi.nlm.nih.gov/gene/?term=51026 "CGI-141, GCT2, GOT1, GOT1B, YMR292W " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014309 51027 BOLA1 http://www.ncbi.nlm.nih.gov/gene/?term=51027 CGI-143 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014310 51028 VPS36 http://www.ncbi.nlm.nih.gov/gene/?term=51028 "C13orf9, CGI-145, EAP45 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014311 51028 VPS36 http://www.ncbi.nlm.nih.gov/gene/?term=51028 "C13orf9, CGI-145, EAP45 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014312 51029 DESI2 http://www.ncbi.nlm.nih.gov/gene/?term=51029 "C1orf121, CGI-146, DESI, DESI1, DeSI-2, FAM152A, PNAS-4, PPPDE1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014313 51029 DESI2 http://www.ncbi.nlm.nih.gov/gene/?term=51029 "C1orf121, CGI-146, DESI, DESI1, DeSI-2, FAM152A, PNAS-4, PPPDE1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014314 51030 TVP23B http://www.ncbi.nlm.nih.gov/gene/?term=51030 "CGI-148, FAM18B, FAM18B1, NPD008, YDR084C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014315 51031 GLOD4 http://www.ncbi.nlm.nih.gov/gene/?term=51031 "C17orf25, CGI-150, HC71 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014316 51031 GLOD4 http://www.ncbi.nlm.nih.gov/gene/?term=51031 "C17orf25, CGI-150, HC71 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014317 51035 UBXN1 http://www.ncbi.nlm.nih.gov/gene/?term=51035 "2B28, SAKS1, UBXD10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014318 51035 UBXN1 http://www.ncbi.nlm.nih.gov/gene/?term=51035 "2B28, SAKS1, UBXD10 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014319 51035 UBXN1 http://www.ncbi.nlm.nih.gov/gene/?term=51035 "2B28, SAKS1, UBXD10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014320 51042 ZNF593 http://www.ncbi.nlm.nih.gov/gene/?term=51042 ZT86 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014321 51042 ZNF593 http://www.ncbi.nlm.nih.gov/gene/?term=51042 ZT86 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014322 51053 GMNN http://www.ncbi.nlm.nih.gov/gene/?term=51053 "Gem, MGORS6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014323 51053 GMNN http://www.ncbi.nlm.nih.gov/gene/?term=51053 Gem mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014324 51056 LAP3 http://www.ncbi.nlm.nih.gov/gene/?term=51056 "HEL-S-106, LAP, LAPEP, PEPS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014325 51056 LAP3 http://www.ncbi.nlm.nih.gov/gene/?term=51056 "HEL-S-106, LAP, LAPEP, PEPS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014326 51056 LAP3 http://www.ncbi.nlm.nih.gov/gene/?term=51056 "HEL-S-106, LAP, LAPEP, PEPS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014327 51057 WDPCP http://www.ncbi.nlm.nih.gov/gene/?term=51057 "BBS15, C2orf86, CHDTHP, FRITZ, FRTZ " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014328 51058 ZNF691 http://www.ncbi.nlm.nih.gov/gene/?term=51058 Zfp691 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014329 51060 TXNDC12 http://www.ncbi.nlm.nih.gov/gene/?term=51060 "AG1, AGR1, ERP16, ERP18, ERP19, PDIA16, TLP19, hAG-1, hTLP19 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014330 51065 RPS27L http://www.ncbi.nlm.nih.gov/gene/?term=51065 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014331 51065 RPS27L http://www.ncbi.nlm.nih.gov/gene/?term=51065 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014332 51065 RPS27L http://www.ncbi.nlm.nih.gov/gene/?term=51065 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014333 51065 RPS27L http://www.ncbi.nlm.nih.gov/gene/?term=51065 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014334 51067 YARS2 http://www.ncbi.nlm.nih.gov/gene/?term=51067 "CGI-04, MLASA2, MT-TYRRS, TYRRS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014335 51067 YARS2 http://www.ncbi.nlm.nih.gov/gene/?term=51067 "CGI-04, MLASA2, MT-TYRRS, TYRRS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014336 51068 NMD3 http://www.ncbi.nlm.nih.gov/gene/?term=51068 CGI-07 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014337 51069 MRPL2 http://www.ncbi.nlm.nih.gov/gene/?term=51069 "CGI-22, MRP-L14, RPML14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014338 51069 MRPL2 http://www.ncbi.nlm.nih.gov/gene/?term=51069 "CGI-22, MRP-L14, RPML14 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014339 51069 MRPL2 http://www.ncbi.nlm.nih.gov/gene/?term=51069 "CGI-22, MRP-L14, RPML14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014340 5106 PCK2 http://www.ncbi.nlm.nih.gov/gene/?term=5106 "PEPCK, PEPCK-M, PEPCK2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014341 51070 NOSIP http://www.ncbi.nlm.nih.gov/gene/?term=51070 CGI-25 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014342 51070 NOSIP http://www.ncbi.nlm.nih.gov/gene/?term=51070 CGI-25 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014343 51070 NOSIP http://www.ncbi.nlm.nih.gov/gene/?term=51070 CGI-25 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014344 51071 DERA http://www.ncbi.nlm.nih.gov/gene/?term=51071 "CGI-26, DEOC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014345 51071 DERA http://www.ncbi.nlm.nih.gov/gene/?term=51071 "CGI-26, DEOC " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014346 51071 DERA http://www.ncbi.nlm.nih.gov/gene/?term=51071 "CGI-26, DEOC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014347 51073 MRPL4 http://www.ncbi.nlm.nih.gov/gene/?term=51073 "CGI-28, L4mt " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014348 51074 APIP http://www.ncbi.nlm.nih.gov/gene/?term=51074 "APIP2, CGI-29, CGI29, MMRP19, hAPIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014349 51075 TMX2 http://www.ncbi.nlm.nih.gov/gene/?term=51075 "CGI-31, PDIA12, PIG26, TXNDC14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014350 51076 CUTC http://www.ncbi.nlm.nih.gov/gene/?term=51076 CGI-32 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014351 51076 CUTC http://www.ncbi.nlm.nih.gov/gene/?term=51076 CGI-32 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014352 51077 FCF1 http://www.ncbi.nlm.nih.gov/gene/?term=51077 "Bka, C14orf111, CGI-35, UTP24 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014353 51077 FCF1 http://www.ncbi.nlm.nih.gov/gene/?term=51077 "Bka, C14orf111, CGI-35, UTP24 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014354 51077 FCF1 http://www.ncbi.nlm.nih.gov/gene/?term=51077 "Bka, C14orf111, CGI-35, UTP24 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014355 51078 THAP4 http://www.ncbi.nlm.nih.gov/gene/?term=51078 "CGI-36, PP238 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014356 51079 NDUFA13 http://www.ncbi.nlm.nih.gov/gene/?term=51079 "B16.6, CDA016, CGI-39, GRIM-19, GRIM19 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014357 51081 MRPS7 http://www.ncbi.nlm.nih.gov/gene/?term=51081 "MRP-S, MRP-S7, RP-S7, RPMS7, S7mt, bMRP27a " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014358 51081 MRPS7 http://www.ncbi.nlm.nih.gov/gene/?term=51081 "MRP-S, MRP-S7, RP-S7, RPMS7, S7mt, bMRP27a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014359 51082 POLR1D http://www.ncbi.nlm.nih.gov/gene/?term=51082 "AC19, POLR1C, RPA16, RPA9, RPAC2, RPC16, RPO1-3, TCS2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014360 51082 POLR1D http://www.ncbi.nlm.nih.gov/gene/?term=51082 "AC19, POLR1C, RPA16, RPA9, RPAC2, RPC16, RPO1-3, TCS2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014361 51083 GAL http://www.ncbi.nlm.nih.gov/gene/?term=51083 "ETL8-GMAP, GALN, GLNN, GMAP, GAL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014362 51083 GAL http://www.ncbi.nlm.nih.gov/gene/?term=51083 "ETL8-GMAP, GALN, GLNN, GMAP, GAL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014363 51084 CRYL1 http://www.ncbi.nlm.nih.gov/gene/?term=51084 "GDH, HEL30, lambda-CRY " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014364 51085 MLXIPL http://www.ncbi.nlm.nih.gov/gene/?term=51085 "CHREBP, MIO, MONDOB, WBSCR14, WS-bHLH, bHLHd14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014365 5108 PCM1 http://www.ncbi.nlm.nih.gov/gene/?term=5108 "PTC4, RET/PCM-1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014366 5108 PCM1 http://www.ncbi.nlm.nih.gov/gene/?term=5108 "PTC4, RET/PCM-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014367 5108 PCM1 http://www.ncbi.nlm.nih.gov/gene/?term=5108 "PTC4, RET/PCM-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014368 51090 PLLP http://www.ncbi.nlm.nih.gov/gene/?term=51090 "PMLP, TM4SF11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014369 51090 PLLP http://www.ncbi.nlm.nih.gov/gene/?term=51090 "PMLP, TM4SF11 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014370 51091 SEPSECS http://www.ncbi.nlm.nih.gov/gene/?term=51091 "LP, PCH2D, SLA, SLA/LP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014371 51092 SIDT2 http://www.ncbi.nlm.nih.gov/gene/?term=51092 CGI-40 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014372 51092 SIDT2 http://www.ncbi.nlm.nih.gov/gene/?term=51092 CGI-40 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014373 51094 ADIPOR1 http://www.ncbi.nlm.nih.gov/gene/?term=51094 "ACDCR1, CGI-45, CGI45, PAQR1, TESBP1A " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014374 51094 ADIPOR1 http://www.ncbi.nlm.nih.gov/gene/?term=51094 "ACDCR1, CGI-45, CGI45, PAQR1, TESBP1A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014375 51095 TRNT1 http://www.ncbi.nlm.nih.gov/gene/?term=51095 "CCA1, CGI-47, MtCCA, SIFD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014376 51096 UTP18 http://www.ncbi.nlm.nih.gov/gene/?term=51096 "CGI-48, WDR50 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014377 51096 UTP18 http://www.ncbi.nlm.nih.gov/gene/?term=51096 "CGI-48, WDR50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014378 51097 SCCPDH http://www.ncbi.nlm.nih.gov/gene/?term=51097 "CGI-49, NET11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014379 51097 SCCPDH http://www.ncbi.nlm.nih.gov/gene/?term=51097 "CGI-49, NET11 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014380 51099 ABHD5 http://www.ncbi.nlm.nih.gov/gene/?term=51099 "CDS, CGI58, IECN2, NCIE2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014381 51099 ABHD5 http://www.ncbi.nlm.nih.gov/gene/?term=51099 "CDS, CGI58, IECN2, NCIE2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014382 51099 ABHD5 http://www.ncbi.nlm.nih.gov/gene/?term=51099 "CDS, CGI58, IECN2, NCIE2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014383 51100 SH3GLB1 http://www.ncbi.nlm.nih.gov/gene/?term=51100 "Bif-1, CGI-61, PPP1R70, dJ612B15.2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014384 51100 SH3GLB1 http://www.ncbi.nlm.nih.gov/gene/?term=51100 "Bif-1, CGI-61, PPP1R70, dJ612B15.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014385 51102 MECR http://www.ncbi.nlm.nih.gov/gene/?term=51102 "CGI-63, FASN2B, NRBF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014386 51103 NDUFAF1 http://www.ncbi.nlm.nih.gov/gene/?term=51103 "CGI-65, CGI65, CIA30 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014387 51104 ABHD17B http://www.ncbi.nlm.nih.gov/gene/?term=51104 "C9orf77, CGI-67, FAM108B1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014388 51104 ABHD17B http://www.ncbi.nlm.nih.gov/gene/?term=51104 "C9orf77, CGI-67, FAM108B1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014389 51104 ABHD17B http://www.ncbi.nlm.nih.gov/gene/?term=51104 "C9orf77, CGI-67, FAM108B1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014390 51104 ABHD17B http://www.ncbi.nlm.nih.gov/gene/?term=51104 "C9orf77, CGI-67, FAM108B1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014391 51105 PHF20L1 http://www.ncbi.nlm.nih.gov/gene/?term=51105 "CGI-72, TDRD20B, URLC1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014392 51105 PHF20L1 http://www.ncbi.nlm.nih.gov/gene/?term=51105 "CGI-72, TDRD20B, URLC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014393 51106 TFB1M http://www.ncbi.nlm.nih.gov/gene/?term=51106 "CGI-75, CGI75, mtTFB, mtTFB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014394 51107 APH1A http://www.ncbi.nlm.nih.gov/gene/?term=51107 "6530402N02Rik, APH-1, APH-1A, CGI-78 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014395 51107 APH1A http://www.ncbi.nlm.nih.gov/gene/?term=51107 "6530402N02Rik, APH-1, APH-1A, CGI-78 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014396 51107 APH1A http://www.ncbi.nlm.nih.gov/gene/?term=51107 "6530402N02Rik, APH-1, APH-1A, CGI-78 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014397 51108 METTL9 http://www.ncbi.nlm.nih.gov/gene/?term=51108 "CGI-81, DREV, DREV1, PAP1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014398 51108 METTL9 http://www.ncbi.nlm.nih.gov/gene/?term=51108 "CGI-81, DREV, DREV1, PAP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014399 51108 METTL9 http://www.ncbi.nlm.nih.gov/gene/?term=51108 "CGI-81, DREV, DREV1, PAP1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014400 51108 METTL9 http://www.ncbi.nlm.nih.gov/gene/?term=51108 "CGI-81, DREV, DREV1, PAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014401 51109 RDH11 http://www.ncbi.nlm.nih.gov/gene/?term=51109 "ARSDR1, CGI82, HCBP12, MDT1, PSDR1, RALR1, RDJCSS, SCALD, SDR7C1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014402 5110 PCMT1 http://www.ncbi.nlm.nih.gov/gene/?term=5110 PIMT mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014403 5110 PCMT1 http://www.ncbi.nlm.nih.gov/gene/?term=5110 PIMT mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014404 5110 PCMT1 http://www.ncbi.nlm.nih.gov/gene/?term=5110 PIMT mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014405 51110 LACTB2 http://www.ncbi.nlm.nih.gov/gene/?term=51110 CGI-83 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014406 51110 LACTB2 http://www.ncbi.nlm.nih.gov/gene/?term=51110 CGI-83 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014407 51112 TRAPPC12 http://www.ncbi.nlm.nih.gov/gene/?term=51112 "CGI-87, TTC-15, TTC15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014408 51114 ZDHHC9 http://www.ncbi.nlm.nih.gov/gene/?term=51114 "CGI89, CXorf11, DHHC9, MMSA1, MRXSZ, ZDHHC10, ZNF379, ZNF380 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014409 51114 ZDHHC9 http://www.ncbi.nlm.nih.gov/gene/?term=51114 "CGI89, CXorf11, DHHC9, MMSA1, MRXSZ, ZDHHC10, ZNF379, ZNF380 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014410 51115 RMDN1 http://www.ncbi.nlm.nih.gov/gene/?term=51115 "CGI-90, FAM82B, RMD-1, RMD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014411 51115 RMDN1 http://www.ncbi.nlm.nih.gov/gene/?term=51115 "CGI-90, FAM82B, RMD-1, RMD1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014412 51115 RMDN1 http://www.ncbi.nlm.nih.gov/gene/?term=51115 "CGI-90, FAM82B, RMD-1, RMD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014413 51116 MRPS2 http://www.ncbi.nlm.nih.gov/gene/?term=51116 "CGI-91, MRP-S2, S2mt " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014414 51116 MRPS2 http://www.ncbi.nlm.nih.gov/gene/?term=51116 "CGI-91, MRP-S2, S2mt " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014415 51117 COQ4 http://www.ncbi.nlm.nih.gov/gene/?term=51117 "CGI-92, COQ10D7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014416 51118 UTP11 http://www.ncbi.nlm.nih.gov/gene/?term=51118 "CGI-94, CGI94L, UTP11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014417 51118 UTP11 http://www.ncbi.nlm.nih.gov/gene/?term=51118 "CGI-94, CGI94L, UTP11 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014418 51118 UTP11 http://www.ncbi.nlm.nih.gov/gene/?term=51118 "CGI-94, CGI94L, UTP11 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014419 51119 SBDS http://www.ncbi.nlm.nih.gov/gene/?term=51119 "CGI-97, SDS, SWDS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014420 5111 PCNA http://www.ncbi.nlm.nih.gov/gene/?term=5111 ATLD2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014421 5111 PCNA http://www.ncbi.nlm.nih.gov/gene/?term=5111 ATLD2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014422 51121 RPL26L1 http://www.ncbi.nlm.nih.gov/gene/?term=51121 RPL26P1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014423 51122 COMMD2 http://www.ncbi.nlm.nih.gov/gene/?term=51122 HSPC042 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014424 51122 COMMD2 http://www.ncbi.nlm.nih.gov/gene/?term=51122 HSPC042 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014425 51123 ZNF706 http://www.ncbi.nlm.nih.gov/gene/?term=51123 "HSPC038, PNAS-106, PNAS-113 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014426 51123 ZNF706 http://www.ncbi.nlm.nih.gov/gene/?term=51123 "HSPC038, PNAS-106, PNAS-113 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014427 51124 IER3IP1 http://www.ncbi.nlm.nih.gov/gene/?term=51124 "HSPC039, MEDS, PRO2309 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014428 51124 IER3IP1 http://www.ncbi.nlm.nih.gov/gene/?term=51124 "HSPC039, MEDS, PRO2309 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014429 51125 GOLGA7 http://www.ncbi.nlm.nih.gov/gene/?term=51125 "GCP16, GOLGA3AP1A, HSPC041, GOLGA7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014430 51126 NAA20 http://www.ncbi.nlm.nih.gov/gene/?term=51126 "NAT3, NAT3P, NAT5, NAT5P, dJ1002M8.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014431 51128 SAR1B http://www.ncbi.nlm.nih.gov/gene/?term=51128 "ANDD, CMRD, GTBPB, SARA2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014432 51128 SAR1B http://www.ncbi.nlm.nih.gov/gene/?term=51128 "ANDD, CMRD, GTBPB, SARA2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014433 51128 SAR1B http://www.ncbi.nlm.nih.gov/gene/?term=51128 "ANDD, CMRD, GTBPB, SARA2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014434 51129 ANGPTL4 http://www.ncbi.nlm.nih.gov/gene/?term=51129 "ARP4, FIAF, HARP, HFARP, NL2, PGAR, TGQTL, UNQ171, pp1158 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014435 51131 PHF11 http://www.ncbi.nlm.nih.gov/gene/?term=51131 "APY, BCAP, IGEL, IGER, IGHER, NY-REN-34, NYREN34 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014436 51131 PHF11 http://www.ncbi.nlm.nih.gov/gene/?term=51131 "APY, BCAP, IGEL, IGER, IGHER, NY-REN-34, NYREN34 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014437 51132 RLIM http://www.ncbi.nlm.nih.gov/gene/?term=51132 "NY-REN-43, RNF12 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014438 51133 KCTD3 http://www.ncbi.nlm.nih.gov/gene/?term=51133 NY-REN-45 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014439 51133 KCTD3 http://www.ncbi.nlm.nih.gov/gene/?term=51133 NY-REN-45 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014440 51135 IRAK4 http://www.ncbi.nlm.nih.gov/gene/?term=51135 "IPD1, IRAK-4, NY-REN-64, REN64 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014441 51138 COPS4 http://www.ncbi.nlm.nih.gov/gene/?term=51138 CSN4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014442 51141 INSIG2 http://www.ncbi.nlm.nih.gov/gene/?term=51141 INSIG-2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014443 51141 INSIG2 http://www.ncbi.nlm.nih.gov/gene/?term=51141 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014444 51142 CHCHD2 http://www.ncbi.nlm.nih.gov/gene/?term=51142 "C7orf17, MNRR1, NS2TP, PARK22 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014445 51142 CHCHD2 http://www.ncbi.nlm.nih.gov/gene/?term=51142 "C7orf17, MNRR1, NS2TP, PARK22 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014446 51143 DYNC1LI1 http://www.ncbi.nlm.nih.gov/gene/?term=51143 "DNCLI1, LIC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014447 51144 HSD17B12 http://www.ncbi.nlm.nih.gov/gene/?term=51144 "KAR, SDR12C1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014448 51144 HSD17B12 http://www.ncbi.nlm.nih.gov/gene/?term=51144 "KAR, SDR12C1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014449 51147 ING4 http://www.ncbi.nlm.nih.gov/gene/?term=51147 "my036, p29ING4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014450 51150 SDF4 http://www.ncbi.nlm.nih.gov/gene/?term=51150 "Cab45, SDF-4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014451 51154 MRTO4 http://www.ncbi.nlm.nih.gov/gene/?term=51154 "C1orf33, MRT4, dJ657E11.4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014452 51154 MRTO4 http://www.ncbi.nlm.nih.gov/gene/?term=51154 "C1orf33, MRT4, dJ657E11.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014453 51155 HN1 http://www.ncbi.nlm.nih.gov/gene/?term=51155 "ARM2A, HN1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014454 51155 HN1 http://www.ncbi.nlm.nih.gov/gene/?term=51155 "ARM2, HN1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014455 51160 VPS28 http://www.ncbi.nlm.nih.gov/gene/?term=51160 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014456 51162 EGFL7 http://www.ncbi.nlm.nih.gov/gene/?term=51162 "NEU1, VE-STATIN, ZNEU1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014457 51163 DBR1 http://www.ncbi.nlm.nih.gov/gene/?term=51163 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014458 51163 DBR1 http://www.ncbi.nlm.nih.gov/gene/?term=51163 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014459 51163 DBR1 http://www.ncbi.nlm.nih.gov/gene/?term=51163 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014460 51164 DCTN4 http://www.ncbi.nlm.nih.gov/gene/?term=51164 "DYN4, P62 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014461 51164 DCTN4 http://www.ncbi.nlm.nih.gov/gene/?term=51164 "DYN4, P62 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014462 51164 DCTN4 http://www.ncbi.nlm.nih.gov/gene/?term=51164 "DYN4, P62 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014463 51166 AADAT http://www.ncbi.nlm.nih.gov/gene/?term=51166 "KAT2, KATII " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014464 51167 CYB5R4 http://www.ncbi.nlm.nih.gov/gene/?term=51167 "NCB5OR, cb5/cb5R, dJ676J13.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014465 51167 CYB5R4 http://www.ncbi.nlm.nih.gov/gene/?term=51167 "NCB5OR, cb5/cb5R, dJ676J13.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014466 5116 PCNT http://www.ncbi.nlm.nih.gov/gene/?term=5116 "KEN, MOPD2, PCN2, PCNTB, PCTN2, SCKL4, PCNT " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00014467 5116 PCNT http://www.ncbi.nlm.nih.gov/gene/?term=5116 "KEN, MOPD2, PCN2, PCNTB, PCTN2, SCKL4, PCNT " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014468 5116 PCNT http://www.ncbi.nlm.nih.gov/gene/?term=5116 "KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014469 51170 HSD17B11 http://www.ncbi.nlm.nih.gov/gene/?term=51170 "17-BETA-HSD11, 17-BETA-HSDXI, 17BHSD11, DHRS8, PAN1B, RETSDR2, SDR16C2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014470 51170 HSD17B11 http://www.ncbi.nlm.nih.gov/gene/?term=51170 "17-BETA-HSD11, 17-BETA-HSDXI, 17BHSD11, DHRS8, PAN1B, RETSDR2, SDR16C2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014471 51171 HSD17B14 http://www.ncbi.nlm.nih.gov/gene/?term=51171 "DHRS10, SDR47C1, retSDR3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014472 51174 TUBD1 http://www.ncbi.nlm.nih.gov/gene/?term=51174 TUBD mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014473 51174 TUBD1 http://www.ncbi.nlm.nih.gov/gene/?term=51174 TUBD mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014474 51175 TUBE1 http://www.ncbi.nlm.nih.gov/gene/?term=51175 "TUBE, dJ142L7.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014475 51176 LEF1 http://www.ncbi.nlm.nih.gov/gene/?term=51176 "LEF-1, TCF10, TCF1ALPHA, TCF7L3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014476 51177 PLEKHO1 http://www.ncbi.nlm.nih.gov/gene/?term=51177 "CKIP-1, CKIP1, JBP, OC120 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014477 51177 PLEKHO1 http://www.ncbi.nlm.nih.gov/gene/?term=51177 "CKIP-1, CKIP1, JBP, OC120 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014478 51181 DCXR http://www.ncbi.nlm.nih.gov/gene/?term=51181 "DCR, HCR2, HCRII, KIDCR, P34H, PNTSU, SDR20C1, XR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014479 51182 HSPA14 http://www.ncbi.nlm.nih.gov/gene/?term=51182 "HSP70-4, HSP70L1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014480 51184 GPN3 http://www.ncbi.nlm.nih.gov/gene/?term=51184 ATPBD1C mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014481 51185 CRBN http://www.ncbi.nlm.nih.gov/gene/?term=51185 "MRT2, MRT2A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014482 51185 CRBN http://www.ncbi.nlm.nih.gov/gene/?term=51185 "MRT2, MRT2A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014483 51186 TCEAL9 http://www.ncbi.nlm.nih.gov/gene/?term=51186 "WBP5, WEX6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014484 51187 RSL24D1 http://www.ncbi.nlm.nih.gov/gene/?term=51187 "C15orf15, HRP-L30-iso, L30, RLP24, RPL24, RPL24L, TVAS3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014485 51188 SS18L2 http://www.ncbi.nlm.nih.gov/gene/?term=51188 KIAA-iso mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014486 51188 SS18L2 http://www.ncbi.nlm.nih.gov/gene/?term=51188 KIAA-iso mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014487 5118 PCOLCE http://www.ncbi.nlm.nih.gov/gene/?term=5118 "PCPE, PCPE-1, PCPE1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014488 51192 CKLF http://www.ncbi.nlm.nih.gov/gene/?term=51192 "C321, CKLF2, CKLF3, CKLF4, HSPC224, UCK-1, CKLF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014489 51192 CKLF http://www.ncbi.nlm.nih.gov/gene/?term=51192 "C321, CKLF2, CKLF3, CKLF4, HSPC224, UCK-1, CKLF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014490 51192 CKLF http://www.ncbi.nlm.nih.gov/gene/?term=51192 "C32, CKLF1, CKLF2, CKLF3, CKLF4, HSPC224, UCK-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014491 51193 ZNF639 http://www.ncbi.nlm.nih.gov/gene/?term=51193 "ANC-2H01, ANC_2H01, ZASC1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014492 51193 ZNF639 http://www.ncbi.nlm.nih.gov/gene/?term=51193 "ANC-2H01, ANC_2H01, ZASC1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014493 51194 IPO11 http://www.ncbi.nlm.nih.gov/gene/?term=51194 RanBP11 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014494 51194 IPO11 http://www.ncbi.nlm.nih.gov/gene/?term=51194 RanBP11 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014495 51199 NIN http://www.ncbi.nlm.nih.gov/gene/?term=51199 SCKL7 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014496 51199 NIN http://www.ncbi.nlm.nih.gov/gene/?term=51199 SCKL7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014497 5119 CHMP1A http://www.ncbi.nlm.nih.gov/gene/?term=5119 "CHMP1, PCH8, PCOLN3, PRSM1, VPS46-1, VPS46A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014498 5119 CHMP1A http://www.ncbi.nlm.nih.gov/gene/?term=5119 "CHMP1, PCH8, PCOLN3, PRSM1, VPS46-1, VPS46A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014499 5119 CHMP1A http://www.ncbi.nlm.nih.gov/gene/?term=5119 "CHMP1, PCH8, PCOLN3, PRSM1, VPS46-1, VPS46A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014500 51200 CPA4 http://www.ncbi.nlm.nih.gov/gene/?term=51200 CPA3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014501 51201 ZDHHC2 http://www.ncbi.nlm.nih.gov/gene/?term=51201 "DHHC2, ZNF372 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014502 51203 NUSAP1 http://www.ncbi.nlm.nih.gov/gene/?term=51203 "ANKT, BM037, LNP, NUSAP, PRO0310p1, Q0310, SAPL " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014503 51203 NUSAP1 http://www.ncbi.nlm.nih.gov/gene/?term=51203 "ANKT, BM037, LNP, NUSAP, PRO0310p1, Q0310, SAPL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014504 51203 NUSAP1 http://www.ncbi.nlm.nih.gov/gene/?term=51203 "ANKT, BM037, LNP, NUSAP, PRO0310p1, Q0310, SAPL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014505 51204 TACO1 http://www.ncbi.nlm.nih.gov/gene/?term=51204 CCDC44 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014506 51205 ACP6 http://www.ncbi.nlm.nih.gov/gene/?term=51205 "ACPL1, LPAP, PACPL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014507 51205 ACP6 http://www.ncbi.nlm.nih.gov/gene/?term=51205 "ACPL1, LPAP, PACPL1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014508 51205 ACP6 http://www.ncbi.nlm.nih.gov/gene/?term=51205 "ACPL1, LPAP, PACPL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014509 51207 DUSP13 http://www.ncbi.nlm.nih.gov/gene/?term=51207 "BEDPA, DUSP13B, MDSP, SKRP4, TMDP, DUSP13 " mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00014510 51208 CLDN18 http://www.ncbi.nlm.nih.gov/gene/?term=51208 "SFTA5, SFTPJ " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014511 51218 GLRX5 http://www.ncbi.nlm.nih.gov/gene/?term=51218 "C14orf87, FLB4739, GRX5, PR01238, PRO1238, PRSA, SIDBA3, SPAHGC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014512 5121 PCP4 http://www.ncbi.nlm.nih.gov/gene/?term=5121 PEP-19 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014513 51222 ZNF219 http://www.ncbi.nlm.nih.gov/gene/?term=51222 ZFP219 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014514 51222 ZNF219 http://www.ncbi.nlm.nih.gov/gene/?term=51222 ZFP219 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014515 51227 PIGP http://www.ncbi.nlm.nih.gov/gene/?term=51227 "DCRC, DCRC-S, DSCR5, DSRC, PIG-P " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014516 51227 PIGP http://www.ncbi.nlm.nih.gov/gene/?term=51227 "DCRC, DCRC-S, DSCR5, DSRC " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014517 51228 GLTP http://www.ncbi.nlm.nih.gov/gene/?term=51228 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014518 51231 VRK3 http://www.ncbi.nlm.nih.gov/gene/?term=51231 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014519 51232 CRIM1 http://www.ncbi.nlm.nih.gov/gene/?term=51232 "CRIM-1, S52 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014520 51232 CRIM1 http://www.ncbi.nlm.nih.gov/gene/?term=51232 "CRIM-1, S52 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014521 51232 CRIM1 http://www.ncbi.nlm.nih.gov/gene/?term=51232 "CRIM-1, S52 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014522 51232 CRIM1 http://www.ncbi.nlm.nih.gov/gene/?term=51232 "CRIM-1, S52 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014523 51234 EMC4 http://www.ncbi.nlm.nih.gov/gene/?term=51234 "PIG17, TMEM85 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014524 51236 HGH1 http://www.ncbi.nlm.nih.gov/gene/?term=51236 "BRP16, BRP16L, C8orf30A, C8orf30B, FAM203A, FAM203B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014525 51239 ANKRD39 http://www.ncbi.nlm.nih.gov/gene/?term=51239 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014526 51241 COX16 http://www.ncbi.nlm.nih.gov/gene/?term=51241 "C14orf112, HSPC203 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014527 51241 COX16 http://www.ncbi.nlm.nih.gov/gene/?term=51241 "C14orf112, HSPC203 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014528 51241 COX16 http://www.ncbi.nlm.nih.gov/gene/?term=51241 "C14orf112, HSPC203 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014529 51244 CCDC174 http://www.ncbi.nlm.nih.gov/gene/?term=51244 "C3orf19, HSPC212, IHPMR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014530 51246 SHISA5 http://www.ncbi.nlm.nih.gov/gene/?term=51246 SCOTIN mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014531 51246 SHISA5 http://www.ncbi.nlm.nih.gov/gene/?term=51246 SCOTIN mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014532 51247 PAIP2 http://www.ncbi.nlm.nih.gov/gene/?term=51247 "PAIP-2A, PAIP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014533 51247 PAIP2 http://www.ncbi.nlm.nih.gov/gene/?term=51247 "PAIP-2A, PAIP2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014534 51247 PAIP2 http://www.ncbi.nlm.nih.gov/gene/?term=51247 "PAIP-2, PAIP2A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014535 51248 PDZD11 http://www.ncbi.nlm.nih.gov/gene/?term=51248 "AIPP1, PDZK11, PISP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014536 51248 PDZD11 http://www.ncbi.nlm.nih.gov/gene/?term=51248 "AIPP1, PDZK11, PISP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014537 51248 PDZD11 http://www.ncbi.nlm.nih.gov/gene/?term=51248 "AIPP1, PDZK11, PISP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014538 51249 TMEM69 http://www.ncbi.nlm.nih.gov/gene/?term=51249 C1orf154 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014539 51249 TMEM69 http://www.ncbi.nlm.nih.gov/gene/?term=51249 C1orf154 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014540 51250 C6orf203 http://www.ncbi.nlm.nih.gov/gene/?term=51250 "HSPC230, PRED31 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014541 51251 NT5C3A http://www.ncbi.nlm.nih.gov/gene/?term=51251 "NT5C3, P5'N-1, P5N-1, PN-I, POMP, PSN1, UMPH, UMPH1, cN-III, hUMP1, p36 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014542 51251 NT5C3A http://www.ncbi.nlm.nih.gov/gene/?term=51251 "NT5C3, P5'N-1, P5N-1, PN-I, POMP, PSN1, UMPH, UMPH1, cN-III, hUMP1, p36 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014543 51253 MRPL37 http://www.ncbi.nlm.nih.gov/gene/?term=51253 "L37mt, MRP-L2, MRP-L37, MRPL2, RPML2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014544 51253 MRPL37 http://www.ncbi.nlm.nih.gov/gene/?term=51253 "L37mt, MRP-L2, MRP-L37, MRPL2, RPML2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014545 51255 RNF181 http://www.ncbi.nlm.nih.gov/gene/?term=51255 HSPC238 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014546 51256 TBC1D7 http://www.ncbi.nlm.nih.gov/gene/?term=51256 "MGCPH, PIG51, TBC7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014547 51257 MARCH2 http://www.ncbi.nlm.nih.gov/gene/?term=51257 "HSPC240, MARCH-II, RNF172 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014548 51257 MARCH2 http://www.ncbi.nlm.nih.gov/gene/?term=51257 "HSPC240, MARCH-II, RNF172 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014549 51257 MARCH2 http://www.ncbi.nlm.nih.gov/gene/?term=51257 "HSPC240, MARCH-II, RNF172 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014550 51258 MRPL51 http://www.ncbi.nlm.nih.gov/gene/?term=51258 "CDA09, HSPC241, MRP64, bMRP64 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014551 51259 TMEM216 http://www.ncbi.nlm.nih.gov/gene/?term=51259 HSPC244 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014552 51263 MRPL30 http://www.ncbi.nlm.nih.gov/gene/?term=51263 "L28MT, L30MT, MRP-L28, MRP-L30, MRPL28, MRPL28M, RPML28 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014553 51264 MRPL27 http://www.ncbi.nlm.nih.gov/gene/?term=51264 L27mt mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014554 51266 CLEC1B http://www.ncbi.nlm.nih.gov/gene/?term=51266 "1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014555 5126 PCSK2 http://www.ncbi.nlm.nih.gov/gene/?term=5126 "NEC 2, NEC-2, NEC2, PC2, SPC2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014556 51271 UBAP1 http://www.ncbi.nlm.nih.gov/gene/?term=51271 "NAG20, UAP, UBAP, UBAP-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014557 51271 UBAP1 http://www.ncbi.nlm.nih.gov/gene/?term=51271 "NAG20, UAP, UBAP, UBAP-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014558 51272 BET1L http://www.ncbi.nlm.nih.gov/gene/?term=51272 "BET1L1, GOLIM3, GS15, HSPC197 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014559 51272 BET1L http://www.ncbi.nlm.nih.gov/gene/?term=51272 "BET1L1, GOLIM3, GS15, HSPC197 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014560 51274 KLF3 http://www.ncbi.nlm.nih.gov/gene/?term=51274 BKLF mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014561 51275 MAPKAPK5-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=51275 C12orf47 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014562 51277 DNAJC27 http://www.ncbi.nlm.nih.gov/gene/?term=51277 "RBJ, RabJS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014563 51279 C1RL http://www.ncbi.nlm.nih.gov/gene/?term=51279 "C1RL1P, C1r-LP, CLSPa, C1RL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014564 51279 C1RL http://www.ncbi.nlm.nih.gov/gene/?term=51279 "C1RL1, C1RLP, C1r-LP, CLSPa " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014565 5127 CDK16 http://www.ncbi.nlm.nih.gov/gene/?term=5127 "PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014566 5127 CDK16 http://www.ncbi.nlm.nih.gov/gene/?term=5127 "PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014567 51280 GOLM1 http://www.ncbi.nlm.nih.gov/gene/?term=51280 "C9orf155, GOLPH2, GP73, HEL46, PSEC0257, bA379P1.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014568 51280 GOLM1 http://www.ncbi.nlm.nih.gov/gene/?term=51280 "C9orf155, GOLPH2, GP73, HEL46, PSEC0257, bA379P1.3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014569 51280 GOLM1 http://www.ncbi.nlm.nih.gov/gene/?term=51280 "C9orf155, GOLPH2, GP73, HEL46, PSEC0257, bA379P1.3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014570 51280 GOLM1 http://www.ncbi.nlm.nih.gov/gene/?term=51280 "C9orf155, GOLPH2, GP73, HEL46, PSEC0257, bA379P1.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014571 51282 SCAND1 http://www.ncbi.nlm.nih.gov/gene/?term=51282 "RAZ1, SDP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014572 51282 SCAND1 http://www.ncbi.nlm.nih.gov/gene/?term=51282 "RAZ1, SDP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014573 51283 BFAR http://www.ncbi.nlm.nih.gov/gene/?term=51283 "BAR, RNF47 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014574 51283 BFAR http://www.ncbi.nlm.nih.gov/gene/?term=51283 "BAR, RNF47 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014575 51287 COA4 http://www.ncbi.nlm.nih.gov/gene/?term=51287 "CHCHD8, CMC3, E2IG2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014576 51290 ERGIC2 http://www.ncbi.nlm.nih.gov/gene/?term=51290 "CDA14, Erv41, PTX1, cd002 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014577 51290 ERGIC2 http://www.ncbi.nlm.nih.gov/gene/?term=51290 "CDA14, Erv41, PTX1, cd002 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014578 51292 GMPR2 http://www.ncbi.nlm.nih.gov/gene/?term=51292 GMPR 2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014579 51293 CD320 http://www.ncbi.nlm.nih.gov/gene/?term=51293 "8D6, 8D6A, TCBLR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014580 51295 ECSIT http://www.ncbi.nlm.nih.gov/gene/?term=51295 SITPEC mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014581 51295 ECSIT http://www.ncbi.nlm.nih.gov/gene/?term=51295 SITPEC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014582 51299 NRN1 http://www.ncbi.nlm.nih.gov/gene/?term=51299 "NRN, dJ380B8.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014583 51300 TIMMDC1 http://www.ncbi.nlm.nih.gov/gene/?term=51300 C3orf1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014584 51300 TIMMDC1 http://www.ncbi.nlm.nih.gov/gene/?term=51300 C3orf1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014585 51302 CYP39A1 http://www.ncbi.nlm.nih.gov/gene/?term=51302 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014586 51303 FKBP11 http://www.ncbi.nlm.nih.gov/gene/?term=51303 FKBP19 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014587 51304 ZDHHC3 http://www.ncbi.nlm.nih.gov/gene/?term=51304 "DHHC-3, GODZ, ZNF373 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014588 51304 ZDHHC3 http://www.ncbi.nlm.nih.gov/gene/?term=51304 "DHHC-3, GODZ, ZNF373 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014589 51306 FAM13B http://www.ncbi.nlm.nih.gov/gene/?term=51306 "ARHGAP49, C5orf5, FAM13B1, KHCHP, N61 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014590 5130 PCYT1A http://www.ncbi.nlm.nih.gov/gene/?term=5130 "CCTA, CT, CTA, CTPCT, PCYT1, SMDCRD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014591 5130 PCYT1A http://www.ncbi.nlm.nih.gov/gene/?term=5130 "CCTA, CT, CTA, CTPCT, PCYT1, SMDCRD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014592 5130 PCYT1A http://www.ncbi.nlm.nih.gov/gene/?term=5130 "CCTA, CT, CTA, CTPCT, PCYT1, SMDCRD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014593 51312 SLC25A37 http://www.ncbi.nlm.nih.gov/gene/?term=51312 "HT015, MFRN, MFRN1, MSC, MSCP, PRO1278, PRO1584, PRO2217 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014594 51312 SLC25A37 http://www.ncbi.nlm.nih.gov/gene/?term=51312 "HT015, MFRN, MFRN1, MSC, MSCP, PRO1278, PRO1584, PRO2217 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014595 51313 FAM198B http://www.ncbi.nlm.nih.gov/gene/?term=51313 "AD021, AD036, C4orf18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014596 51315 KRCC1 http://www.ncbi.nlm.nih.gov/gene/?term=51315 CHBP2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014597 51316 PLAC8 http://www.ncbi.nlm.nih.gov/gene/?term=51316 "C15, DGIC, PNAS-144, onzin " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014598 51316 PLAC8 http://www.ncbi.nlm.nih.gov/gene/?term=51316 "C15, DGIC, PNAS-144, onzin " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014599 51317 PHF21A http://www.ncbi.nlm.nih.gov/gene/?term=51317 "BHC80, BM-006 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014600 51318 MRPL35 http://www.ncbi.nlm.nih.gov/gene/?term=51318 "L35mt, MRP-L35 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014601 51318 MRPL35 http://www.ncbi.nlm.nih.gov/gene/?term=51318 "L35mt, MRP-L35 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014602 51318 MRPL35 http://www.ncbi.nlm.nih.gov/gene/?term=51318 "L35mt, MRP-L35 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014603 51318 MRPL35 http://www.ncbi.nlm.nih.gov/gene/?term=51318 "L35mt, MRP-L35 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014604 51319 RSRC1 http://www.ncbi.nlm.nih.gov/gene/?term=51319 "BM-011, SFRS21, SRrp53 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014605 51319 RSRC1 http://www.ncbi.nlm.nih.gov/gene/?term=51319 "BM-011, SFRS21, SRrp53 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014606 51321 AMZ2 http://www.ncbi.nlm.nih.gov/gene/?term=51321 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014607 51322 WAC http://www.ncbi.nlm.nih.gov/gene/?term=51322 "BM-016, DESSH, PRO1741, Wwp4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014608 51324 SPG21 http://www.ncbi.nlm.nih.gov/gene/?term=51324 "ACP33, BM-019, GL010, MAST " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014609 51324 SPG21 http://www.ncbi.nlm.nih.gov/gene/?term=51324 "ACP33, BM-019, GL010, MAST " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014610 51324 SPG21 http://www.ncbi.nlm.nih.gov/gene/?term=51324 "ACP33, BM-019, GL010, MAST " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014611 51327 AHSP http://www.ncbi.nlm.nih.gov/gene/?term=51327 "EDRF, ERAF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014612 51329 ARL6IP4 http://www.ncbi.nlm.nih.gov/gene/?term=51329 "SFRS20, SR-25, SRp25, SRrp37 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014613 51330 TNFRSF12A http://www.ncbi.nlm.nih.gov/gene/?term=51330 "CD266, FN14, TWEAKR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014614 51330 TNFRSF12A http://www.ncbi.nlm.nih.gov/gene/?term=51330 "CD266, FN14, TWEAKR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014615 51333 ZNF771 http://www.ncbi.nlm.nih.gov/gene/?term=51333 DSC43 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014616 51334 PRR16 http://www.ncbi.nlm.nih.gov/gene/?term=51334 "DSC54, LARGEN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014617 51335 NGRN http://www.ncbi.nlm.nih.gov/gene/?term=51335 DSC92 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014618 51337 THEM6 http://www.ncbi.nlm.nih.gov/gene/?term=51337 "C8orf55, DSCD75 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014619 51338 MS4A4A http://www.ncbi.nlm.nih.gov/gene/?term=51338 "4SPAN1, CD20-L1, CD20L1, HDCME31P, MS4A4, MS4A7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014620 51341 ZBTB7A http://www.ncbi.nlm.nih.gov/gene/?term=51341 "FBI-1, FBI1, LRF, TIP21, ZBTB7, ZNF857A, pokemon " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014621 51341 ZBTB7A http://www.ncbi.nlm.nih.gov/gene/?term=51341 "FBI-1, FBI1, LRF, TIP21, ZBTB7, ZNF857A, pokemon " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014622 51341 ZBTB7A http://www.ncbi.nlm.nih.gov/gene/?term=51341 "FBI-1, FBI1, LRF, TIP21, ZBTB7, ZNF857A, pokemon " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014623 51343 FZR1 http://www.ncbi.nlm.nih.gov/gene/?term=51343 "CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014624 51343 FZR1 http://www.ncbi.nlm.nih.gov/gene/?term=51343 "CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014625 5134 PDCD2 http://www.ncbi.nlm.nih.gov/gene/?term=5134 "RP8, ZMYND7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014626 5134 PDCD2 http://www.ncbi.nlm.nih.gov/gene/?term=5134 "RP8, ZMYND7 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014627 5134 PDCD2 http://www.ncbi.nlm.nih.gov/gene/?term=5134 "RP8, ZMYND7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014628 51351 ZNF117 http://www.ncbi.nlm.nih.gov/gene/?term=51351 "H-plk, HPF9 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014629 51351 ZNF117 http://www.ncbi.nlm.nih.gov/gene/?term=51351 "H-plk, HPF9 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014630 51351 ZNF117 http://www.ncbi.nlm.nih.gov/gene/?term=51351 "H-plk, HPF9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014631 51360 MBTPS2 http://www.ncbi.nlm.nih.gov/gene/?term=51360 "BRESEK, IFAP, KFSD, KFSDX, OLMSX, S2P " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014632 51366 UBR5 http://www.ncbi.nlm.nih.gov/gene/?term=51366 "DD5, EDD, EDD1, HYD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014633 51366 UBR5 http://www.ncbi.nlm.nih.gov/gene/?term=51366 "DD5, EDD, EDD1, HYD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014634 51367 POP5 http://www.ncbi.nlm.nih.gov/gene/?term=51367 "HSPC004, RPP2, RPP20, hPop5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014635 51368 TEX264 http://www.ncbi.nlm.nih.gov/gene/?term=51368 ZSIG11 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014636 51368 TEX264 http://www.ncbi.nlm.nih.gov/gene/?term=51368 ZSIG11 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014637 51371 POMP http://www.ncbi.nlm.nih.gov/gene/?term=51371 "C13orf12, HSPC014, PNAS-110, UMP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014638 51371 POMP http://www.ncbi.nlm.nih.gov/gene/?term=51371 "C13orf12, HSPC014, PNAS-110, UMP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014639 51371 POMP http://www.ncbi.nlm.nih.gov/gene/?term=51371 "C13orf12, HSPC014, PNAS-110, UMP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014640 51372 TMA7 http://www.ncbi.nlm.nih.gov/gene/?term=51372 "CCDC72, HSPC016 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014641 51374 ATRAID http://www.ncbi.nlm.nih.gov/gene/?term=51374 "APR--3, APR-3, APR3, C2orf28, HSPC013, PRO240, p18 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014642 51375 SNX7 http://www.ncbi.nlm.nih.gov/gene/?term=51375 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014643 51377 UCHL5 http://www.ncbi.nlm.nih.gov/gene/?term=51377 "CGI-70, INO80R, UCH-L5, UCH37 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014644 51379 CRLF3 http://www.ncbi.nlm.nih.gov/gene/?term=51379 "CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014645 51379 CRLF3 http://www.ncbi.nlm.nih.gov/gene/?term=51379 "CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014646 51379 CRLF3 http://www.ncbi.nlm.nih.gov/gene/?term=51379 "CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014647 51379 CRLF3 http://www.ncbi.nlm.nih.gov/gene/?term=51379 "CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014648 51382 ATP6V1D http://www.ncbi.nlm.nih.gov/gene/?term=51382 "ATP6M, VATD, VMA8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014649 51382 ATP6V1D http://www.ncbi.nlm.nih.gov/gene/?term=51382 "ATP6M, VATD, VMA8 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014650 51385 ZNF589 http://www.ncbi.nlm.nih.gov/gene/?term=51385 SZF1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014651 51386 EIF3L http://www.ncbi.nlm.nih.gov/gene/?term=51386 "EIF3EIP, EIF3S11, EIF3S6IP, HSPC021, HSPC025, MSTP005 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014652 51386 EIF3L http://www.ncbi.nlm.nih.gov/gene/?term=51386 "EIF3EIP, EIF3S11, EIF3S6IP, HSPC021, HSPC025, MSTP005 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014653 51388 NIP7 http://www.ncbi.nlm.nih.gov/gene/?term=51388 "CGI-37, HSPC031, KD93 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014654 51389 RWDD1 http://www.ncbi.nlm.nih.gov/gene/?term=51389 "CGI-24, PTD013 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014655 51389 RWDD1 http://www.ncbi.nlm.nih.gov/gene/?term=51389 "CGI-24, PTD013 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014656 51390 AIG1 http://www.ncbi.nlm.nih.gov/gene/?term=51390 "AIG-1, dJ95L4.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014657 51393 TRPV2 http://www.ncbi.nlm.nih.gov/gene/?term=51393 "VRL, VRL-1, VRL1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014658 51397 COMMD10 http://www.ncbi.nlm.nih.gov/gene/?term=51397 PTD002 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014659 51398 WDR83OS http://www.ncbi.nlm.nih.gov/gene/?term=51398 "C19orf56, PTD008 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014660 51398 WDR83OS http://www.ncbi.nlm.nih.gov/gene/?term=51398 "C19orf56, PTD008 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014661 51399 TRAPPC4 http://www.ncbi.nlm.nih.gov/gene/?term=51399 "CGI-104, HSPC172, PTD009, SBDN, SYNBINDIN, TRS23 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014662 513 ATP5D http://www.ncbi.nlm.nih.gov/gene/?term=513 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014663 513 ATP5D http://www.ncbi.nlm.nih.gov/gene/?term=513 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014664 51400 PPME1 http://www.ncbi.nlm.nih.gov/gene/?term=51400 PME-1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014665 51400 PPME1 http://www.ncbi.nlm.nih.gov/gene/?term=51400 PME-1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014666 51406 NOL7 http://www.ncbi.nlm.nih.gov/gene/?term=51406 "C6orf90, PQBP3, RARG-1, dJ223E5.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014667 51406 NOL7 http://www.ncbi.nlm.nih.gov/gene/?term=51406 "C6orf90, PQBP3, RARG-1, dJ223E5.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014668 51409 HEMK1 http://www.ncbi.nlm.nih.gov/gene/?term=51409 "HEMK, MTQ1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014669 51421 AMOTL2 http://www.ncbi.nlm.nih.gov/gene/?term=51421 LCCP mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014670 51421 AMOTL2 http://www.ncbi.nlm.nih.gov/gene/?term=51421 LCCP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014671 51422 PRKAG2 http://www.ncbi.nlm.nih.gov/gene/?term=51422 "AAKG, AAKG2, CMH6, H91620p, WPWS " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014672 51422 PRKAG2 http://www.ncbi.nlm.nih.gov/gene/?term=51422 "AAKG, AAKG2, CMH6, H91620p, WPWS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014673 51427 ZNF107 http://www.ncbi.nlm.nih.gov/gene/?term=51427 "Y8, ZFD25, ZNF588, smap-7 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014674 51427 ZNF107 http://www.ncbi.nlm.nih.gov/gene/?term=51427 "Y8, ZFD25, ZNF588, smap-7 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014675 51428 DDX41 http://www.ncbi.nlm.nih.gov/gene/?term=51428 "ABS, MPLPF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014676 51428 DDX41 http://www.ncbi.nlm.nih.gov/gene/?term=51428 ABS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014677 51429 SNX9 http://www.ncbi.nlm.nih.gov/gene/?term=51429 "SDP1, SH3PX1, SH3PXD3A, WISP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014678 51429 SNX9 http://www.ncbi.nlm.nih.gov/gene/?term=51429 "SDP1, SH3PX1, SH3PXD3A, WISP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014679 51430 SUCO http://www.ncbi.nlm.nih.gov/gene/?term=51430 "C1orf9, CH1, OPT, SLP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014680 51430 SUCO http://www.ncbi.nlm.nih.gov/gene/?term=51430 "C1orf9, CH1, OPT, SLP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014681 51433 ANAPC5 http://www.ncbi.nlm.nih.gov/gene/?term=51433 APC5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014682 51434 ANAPC7 http://www.ncbi.nlm.nih.gov/gene/?term=51434 APC7 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014683 51434 ANAPC7 http://www.ncbi.nlm.nih.gov/gene/?term=51434 APC7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014684 51435 SCARA3 http://www.ncbi.nlm.nih.gov/gene/?term=51435 "APC7, CSR, CSR1, MSLR1, MSRL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014685 51439 FAM8A1 http://www.ncbi.nlm.nih.gov/gene/?term=51439 AHCP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014686 5143 PDE4C http://www.ncbi.nlm.nih.gov/gene/?term=5143 DPDE1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014687 51441 YTHDF2 http://www.ncbi.nlm.nih.gov/gene/?term=51441 "CAHL, HGRG8, NY-REN-2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014688 51441 YTHDF2 http://www.ncbi.nlm.nih.gov/gene/?term=51441 "CAHL, HGRG8, NY-REN-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014689 51444 RNF138 http://www.ncbi.nlm.nih.gov/gene/?term=51444 "HSD-4, NARF, STRIN, hNARF " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014690 51444 RNF138 http://www.ncbi.nlm.nih.gov/gene/?term=51444 "HSD-4, NARF, STRIN, hNARF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014691 51449 PCYOX1 http://www.ncbi.nlm.nih.gov/gene/?term=51449 PCL1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014692 51449 PCYOX1 http://www.ncbi.nlm.nih.gov/gene/?term=51449 PCL1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014693 51449 PCYOX1 http://www.ncbi.nlm.nih.gov/gene/?term=51449 PCL1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014694 51449 PCYOX1 http://www.ncbi.nlm.nih.gov/gene/?term=51449 PCL1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014695 51451 LCMT1 http://www.ncbi.nlm.nih.gov/gene/?term=51451 "CGI-68, LCMT, PPMT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014696 51454 GULP1 http://www.ncbi.nlm.nih.gov/gene/?term=51454 "CED-6, CED6, GULP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014697 51454 GULP1 http://www.ncbi.nlm.nih.gov/gene/?term=51454 "CED-6, CED6, GULP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014698 51455 REV1 http://www.ncbi.nlm.nih.gov/gene/?term=51455 "AIBP80L, REV1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014699 51455 REV1 http://www.ncbi.nlm.nih.gov/gene/?term=51455 REV1L mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014700 5145 PDE6A http://www.ncbi.nlm.nih.gov/gene/?term=5145 "CGPR-A, PDEA, RP43 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014701 5145 PDE6A http://www.ncbi.nlm.nih.gov/gene/?term=5145 "CGPR-A, PDEA, RP43 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014702 51460 SFMBT1 http://www.ncbi.nlm.nih.gov/gene/?term=51460 "RU1, SFMBT, hSFMBT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014703 51460 SFMBT1 http://www.ncbi.nlm.nih.gov/gene/?term=51460 "RU1, SFMBT, hSFMBT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014704 51465 UBE2J1 http://www.ncbi.nlm.nih.gov/gene/?term=51465 "CGI-76, HSPC153, HSPC205, HSU93243, NCUBE-1, NCUBE1, UBC6, UBC6E, Ubc6p " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014705 51465 UBE2J1 http://www.ncbi.nlm.nih.gov/gene/?term=51465 "CGI-76, HSPC153, HSPC205, HSU93243, NCUBE-1, NCUBE1, UBC6, UBC6E, Ubc6p " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014706 51474 LIMA1 http://www.ncbi.nlm.nih.gov/gene/?term=51474 "EPLIN, SREBP3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014707 51474 LIMA1 http://www.ncbi.nlm.nih.gov/gene/?term=51474 "EPLIN, SREBP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014708 51477 ISYNA1 http://www.ncbi.nlm.nih.gov/gene/?term=51477 "INO1, INOS, IPS, IPS 1, IPS-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014709 51478 HSD17B7 http://www.ncbi.nlm.nih.gov/gene/?term=51478 "PRAP, SDR37C1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014710 51479 ANKFY1 http://www.ncbi.nlm.nih.gov/gene/?term=51479 "ANKHZN, BTBD23, ZFYVE14 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014711 51479 ANKFY1 http://www.ncbi.nlm.nih.gov/gene/?term=51479 "ANKHZN, BTBD23, ZFYVE14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014712 5147 PDE6D http://www.ncbi.nlm.nih.gov/gene/?term=5147 "JBTS22, PDED " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014713 51481 VCX3A http://www.ncbi.nlm.nih.gov/gene/?term=51481 "VCX-8r, VCX-A, VCX3, VCX8R, VCXA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014714 51490 C9orf114 http://www.ncbi.nlm.nih.gov/gene/?term=51490 "CENP-32, HSPC109 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014715 51491 NOP16 http://www.ncbi.nlm.nih.gov/gene/?term=51491 "HSPC111, HSPC185 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014716 51493 RTCB http://www.ncbi.nlm.nih.gov/gene/?term=51493 "C22orf28, DJ149A16.6, FAAP, HSPC117 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014717 51493 RTCB http://www.ncbi.nlm.nih.gov/gene/?term=51493 "C22orf28, DJ149A16.6, FAAP, HSPC117 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014718 51495 HACD3 http://www.ncbi.nlm.nih.gov/gene/?term=51495 "B-IND1, BIND1, HSPC121, PTPLAD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014719 51495 HACD3 http://www.ncbi.nlm.nih.gov/gene/?term=51495 "B-IND1, BIND1, HSPC121, PTPLAD1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014720 51496 CTDSPL2 http://www.ncbi.nlm.nih.gov/gene/?term=51496 "HSPC058, HSPC129 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014721 51496 CTDSPL2 http://www.ncbi.nlm.nih.gov/gene/?term=51496 "HSPC058, HSPC129 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014722 51497 NELFCD http://www.ncbi.nlm.nih.gov/gene/?term=51497 "HSPC130, NELF-C, NELF-D, TH1, TH1L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014723 51499 TRIAP1 http://www.ncbi.nlm.nih.gov/gene/?term=51499 "HSPC132, MDM35, P53CSV, WF-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014724 514 ATP5E http://www.ncbi.nlm.nih.gov/gene/?term=514 "ATPE, MC5DN3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014725 514 ATP5E http://www.ncbi.nlm.nih.gov/gene/?term=514 "ATPE, MC5DN3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014726 51501 C11orf73 http://www.ncbi.nlm.nih.gov/gene/?term=51501 "HLD13, HSPC138, HSPC179, Hikeshi, L7RN6, OPI10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014727 51503 CWC15 http://www.ncbi.nlm.nih.gov/gene/?term=51503 "AD002, C11orf5, Cwf15, HSPC148, ORF5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014728 51503 CWC15 http://www.ncbi.nlm.nih.gov/gene/?term=51503 "AD002, C11orf5, Cwf15, HSPC148, ORF5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014729 51504 TRMT112 http://www.ncbi.nlm.nih.gov/gene/?term=51504 "HSPC152, HSPC170, TRM112, TRMT11-2, hTrm112 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014730 51506 UFC1 http://www.ncbi.nlm.nih.gov/gene/?term=51506 HSPC155 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014731 51507 RTFDC1 http://www.ncbi.nlm.nih.gov/gene/?term=51507 "C20orf43, CDAO5, HSPC164, SHUJUN-3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014732 51507 RTFDC1 http://www.ncbi.nlm.nih.gov/gene/?term=51507 "C20orf43, CDAO5, HSPC164, SHUJUN-3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014733 51510 CHMP5 http://www.ncbi.nlm.nih.gov/gene/?term=51510 "C9orf83, CGI-34, HSPC177, PNAS-2, SNF7DC2, Vps60 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014734 51512 GTSE1 http://www.ncbi.nlm.nih.gov/gene/?term=51512 B99 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014735 51512 GTSE1 http://www.ncbi.nlm.nih.gov/gene/?term=51512 B99 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014736 51514 DTL http://www.ncbi.nlm.nih.gov/gene/?term=51514 "CDT2, DCAF2, L2DTL, RAMP " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014737 51514 DTL http://www.ncbi.nlm.nih.gov/gene/?term=51514 "CDT2, DCAF2, L2DTL, RAMP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014738 51514 DTL http://www.ncbi.nlm.nih.gov/gene/?term=51514 "CDT2, DCAF2, L2DTL, RAMP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014739 51517 NCKIPSD http://www.ncbi.nlm.nih.gov/gene/?term=51517 "AF3P21, DIP, DIP1, ORF1, SPIN90, VIP54, WASLBP, WISH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014740 5151 PDE8A http://www.ncbi.nlm.nih.gov/gene/?term=5151 HsT19550 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014741 5151 PDE8A http://www.ncbi.nlm.nih.gov/gene/?term=5151 HsT19550 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014742 51520 LARS http://www.ncbi.nlm.nih.gov/gene/?term=51520 "HSPC192, ILFS11, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS, hr025Cl, LARS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014743 51522 TMEM14C http://www.ncbi.nlm.nih.gov/gene/?term=51522 "C6orf53, HSPC194, MSTP073, NET26, bA421M1.6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014744 51523 CXXC5 http://www.ncbi.nlm.nih.gov/gene/?term=51523 "CF5, HSPC195, RINF, WID " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014745 51523 CXXC5 http://www.ncbi.nlm.nih.gov/gene/?term=51523 "CF5, HSPC195, RINF, WID " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014746 51524 TMEM138 http://www.ncbi.nlm.nih.gov/gene/?term=51524 HSPC196 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014747 51526 OSER1 http://www.ncbi.nlm.nih.gov/gene/?term=51526 "C20orf111, HSPC207, Osr1, Perit1, dJ1183I21.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014748 51527 GSKIP http://www.ncbi.nlm.nih.gov/gene/?term=51527 "C14orf129, HSPC210 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014749 51527 GSKIP http://www.ncbi.nlm.nih.gov/gene/?term=51527 "C14orf129, HSPC210 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014750 51528 JKAMP http://www.ncbi.nlm.nih.gov/gene/?term=51528 "C14orf100, CDA06, HSPC213, HSPC327, JAMP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014751 51529 ANAPC11 http://www.ncbi.nlm.nih.gov/gene/?term=51529 "APC11, Apc11p, HSPC214 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014752 51530 ZC3HC1 http://www.ncbi.nlm.nih.gov/gene/?term=51530 "HSPC216, NIPA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014753 51534 VTA1 http://www.ncbi.nlm.nih.gov/gene/?term=51534 "C6orf55, DRG-1, DRG1, HSPC228, LIP5, My012, SBP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014754 51534 VTA1 http://www.ncbi.nlm.nih.gov/gene/?term=51534 "C6orf55, DRG-1, DRG1, HSPC228, LIP5, My012, SBP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014755 51534 VTA1 http://www.ncbi.nlm.nih.gov/gene/?term=51534 "C6orf55, DRG-1, DRG1, HSPC228, LIP5, My012, SBP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014756 51535 PPHLN1 http://www.ncbi.nlm.nih.gov/gene/?term=51535 "CR, HSPC206, HSPC232 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014757 51535 PPHLN1 http://www.ncbi.nlm.nih.gov/gene/?term=51535 "CR, HSPC206, HSPC232 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014758 51535 PPHLN1 http://www.ncbi.nlm.nih.gov/gene/?term=51535 "CR, HSPC206, HSPC232 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014759 51537 MTFP1 http://www.ncbi.nlm.nih.gov/gene/?term=51537 "HSPC242, MTP18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014760 51538 ZCCHC17 http://www.ncbi.nlm.nih.gov/gene/?term=51538 "HSPC251, PS1D, pNO40 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014761 51538 ZCCHC17 http://www.ncbi.nlm.nih.gov/gene/?term=51538 "HSPC251, PS1D, pNO40 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014762 51540 SCLY http://www.ncbi.nlm.nih.gov/gene/?term=51540 "SCL, hSCL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014763 51540 SCLY http://www.ncbi.nlm.nih.gov/gene/?term=51540 "SCL, hSCL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014764 51545 ZNF581 http://www.ncbi.nlm.nih.gov/gene/?term=51545 HSPC189 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014765 51548 SIRT6 http://www.ncbi.nlm.nih.gov/gene/?term=51548 SIR2L6 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014766 51550 CINP http://www.ncbi.nlm.nih.gov/gene/?term=51550 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014767 51552 RAB14 http://www.ncbi.nlm.nih.gov/gene/?term=51552 "FBP, RAB-14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014768 51552 RAB14 http://www.ncbi.nlm.nih.gov/gene/?term=51552 "FBP, RAB-14 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014769 51559 NT5DC3 http://www.ncbi.nlm.nih.gov/gene/?term=51559 "TU12B1-TY, TU12B1TY " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014770 51559 NT5DC3 http://www.ncbi.nlm.nih.gov/gene/?term=51559 "TU12B1-TY, TU12B1TY " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014771 51559 NT5DC3 http://www.ncbi.nlm.nih.gov/gene/?term=51559 "TU12B1-TY, TU12B1TY " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014772 51561 IL23A http://www.ncbi.nlm.nih.gov/gene/?term=51561 "IL-23, IL-23A, IL23P19, P19, SGRF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014773 51562 MBIP http://www.ncbi.nlm.nih.gov/gene/?term=51562 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014774 51562 MBIP http://www.ncbi.nlm.nih.gov/gene/?term=51562 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014775 51564 HDAC7 http://www.ncbi.nlm.nih.gov/gene/?term=51564 "HD7, HD7A, HDAC7A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014776 51566 ARMCX3 http://www.ncbi.nlm.nih.gov/gene/?term=51566 "ALEX3, GASP6, dJ545K15.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014777 51567 TDP2 http://www.ncbi.nlm.nih.gov/gene/?term=51567 "AD022, EAP2, EAPII, TTRAP, dJ30M3.3, hTDP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014778 51567 TDP2 http://www.ncbi.nlm.nih.gov/gene/?term=51567 "AD022, EAP2, EAPII, TTRAP, dJ30M3.3, hTDP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014779 51569 UFM1 http://www.ncbi.nlm.nih.gov/gene/?term=51569 "BM-002, C13orf20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014780 51569 UFM1 http://www.ncbi.nlm.nih.gov/gene/?term=51569 "BM-002, C13orf20 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014781 51569 UFM1 http://www.ncbi.nlm.nih.gov/gene/?term=51569 "BM-002, C13orf20 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014782 51569 UFM1 http://www.ncbi.nlm.nih.gov/gene/?term=51569 "BM-002, C13orf20 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014783 51569 UFM1 http://www.ncbi.nlm.nih.gov/gene/?term=51569 "BM-002, C13orf20 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014784 51571 FAM49B http://www.ncbi.nlm.nih.gov/gene/?term=51571 "BM-009, L1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014785 51573 GDE1 http://www.ncbi.nlm.nih.gov/gene/?term=51573 "363E6.2, MIR16 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014786 51573 GDE1 http://www.ncbi.nlm.nih.gov/gene/?term=51573 "363E6.2, MIR16 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014787 51582 AZIN1 http://www.ncbi.nlm.nih.gov/gene/?term=51582 "AZI, AZIA1, OAZI, OAZIN, ODC1L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014788 51585 PCF11 http://www.ncbi.nlm.nih.gov/gene/?term=51585 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014789 51585 PCF11 http://www.ncbi.nlm.nih.gov/gene/?term=51585 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014790 51586 MED15 http://www.ncbi.nlm.nih.gov/gene/?term=51586 "ARC105, CAG7A, CTG7A, PCQAP, TIG-1, TIG1, TNRC7 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014791 51586 MED15 http://www.ncbi.nlm.nih.gov/gene/?term=51586 "ARC105, CAG7A, CTG7A, PCQAP, TIG-1, TIG1, TNRC7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014792 5158 PDE6B http://www.ncbi.nlm.nih.gov/gene/?term=5158 "CSNB3, CSNBAD2, PDEB, RP40, rd1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014793 5158 PDE6B http://www.ncbi.nlm.nih.gov/gene/?term=5158 "CSNB3, CSNBAD2, PDEB, RP40, rd1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014794 51592 TRIM33 http://www.ncbi.nlm.nih.gov/gene/?term=51592 "ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014795 51593 SRRT http://www.ncbi.nlm.nih.gov/gene/?term=51593 "ARS2, ASR2, serrate " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014796 51593 SRRT http://www.ncbi.nlm.nih.gov/gene/?term=51593 "ARS2, ASR2, serrate " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014797 51594 NBAS http://www.ncbi.nlm.nih.gov/gene/?term=51594 "ILFS2, NAG, SOPH " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014798 51594 NBAS http://www.ncbi.nlm.nih.gov/gene/?term=51594 "ILFS2, NAG, SOPH " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014799 51596 CUTA http://www.ncbi.nlm.nih.gov/gene/?term=51596 "ACHAP, C6orf82 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014800 51596 CUTA http://www.ncbi.nlm.nih.gov/gene/?term=51596 "ACHAP, C6orf82 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014801 515 ATP5F1 http://www.ncbi.nlm.nih.gov/gene/?term=515 PIG47 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014802 515 ATP5F1 http://www.ncbi.nlm.nih.gov/gene/?term=515 PIG47 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014803 51602 NOP58 http://www.ncbi.nlm.nih.gov/gene/?term=51602 "HSPC120, NOP5, NOP5/NOP58 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014804 51603 METTL13 http://www.ncbi.nlm.nih.gov/gene/?term=51603 "5630401D24Rik, CGI-01, KIAA0859, feat " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014805 51604 PIGT http://www.ncbi.nlm.nih.gov/gene/?term=51604 "CGI-06, MCAHS3, NDAP, PNH2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014806 51604 PIGT http://www.ncbi.nlm.nih.gov/gene/?term=51604 "CGI-06, MCAHS3, NDAP, PNH2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014807 51606 ATP6V1H http://www.ncbi.nlm.nih.gov/gene/?term=51606 "CGI-11, MSTP042, NBP1, SFD, SFDalpha, SFDbeta, VMA13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014808 51608 GET4 http://www.ncbi.nlm.nih.gov/gene/?term=51608 "C7orf20, CEE, CGI-20, TRC35 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014809 5160 PDHA1 http://www.ncbi.nlm.nih.gov/gene/?term=5160 "PDHA, PDHAD, PDHCE1A, PHE1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014810 5160 PDHA1 http://www.ncbi.nlm.nih.gov/gene/?term=5160 "PDHA, PDHAD, PDHCE1A, PHE1A " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014811 5160 PDHA1 http://www.ncbi.nlm.nih.gov/gene/?term=5160 "PDHA, PDHAD, PDHCE1A, PHE1A " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014812 5160 PDHA1 http://www.ncbi.nlm.nih.gov/gene/?term=5160 "PDHA, PDHAD, PDHCE1A, PHE1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014813 51611 DPH5 http://www.ncbi.nlm.nih.gov/gene/?term=51611 "AD-018, CGI-30, HSPC143, NPD015 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014814 51614 ERGIC3 http://www.ncbi.nlm.nih.gov/gene/?term=51614 "C20orf47, CGI-54, Erv46, NY-BR-84, PRO0989, SDBCAG84, dJ477O4.2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014815 51614 ERGIC3 http://www.ncbi.nlm.nih.gov/gene/?term=51614 "C20orf47, CGI-54, Erv46, NY-BR-84, PRO0989, SDBCAG84, dJ477O4.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014816 51616 TAF9B http://www.ncbi.nlm.nih.gov/gene/?term=51616 "DN-7, DN7, TAF9L, TAFII31L, TFIID-31 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014817 51619 UBE2D4 http://www.ncbi.nlm.nih.gov/gene/?term=51619 HBUCE1 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014818 51621 KLF13 http://www.ncbi.nlm.nih.gov/gene/?term=51621 "BTEB3, FKLF2, NSLP1, RFLAT-1, RFLAT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014819 51621 KLF13 http://www.ncbi.nlm.nih.gov/gene/?term=51621 "BTEB3, FKLF2, NSLP1, RFLAT-1, RFLAT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014820 51622 CCZ1 http://www.ncbi.nlm.nih.gov/gene/?term=51622 "C7orf28AA, CGI-43, H_DJ1163J12.2, CCZ1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014821 51622 CCZ1 http://www.ncbi.nlm.nih.gov/gene/?term=51622 "C7orf28A, CCZ1A, CGI-43, H_DJ1163J12.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014822 51629 SLC25A39 http://www.ncbi.nlm.nih.gov/gene/?term=51629 "CGI-69, CGI69 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014823 5162 PDHB http://www.ncbi.nlm.nih.gov/gene/?term=5162 "PDHBD, PDHE1-B, PHE1B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014824 51631 LUC7L2 http://www.ncbi.nlm.nih.gov/gene/?term=51631 "CGI-59, CGI-74, LUC7B2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014825 51633 OTUD6B http://www.ncbi.nlm.nih.gov/gene/?term=51633 "CGI-77, DUBA-5, DUBA5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014826 51633 OTUD6B http://www.ncbi.nlm.nih.gov/gene/?term=51633 "CGI-77, DUBA-5, DUBA5 " mRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00014827 51635 DHRS7 http://www.ncbi.nlm.nih.gov/gene/?term=51635 "CGI-86, SDR34C1, retDSR4, retSDR4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014828 51635 DHRS7 http://www.ncbi.nlm.nih.gov/gene/?term=51635 "CGI-86, SDR34C1, retDSR4, retSDR4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014829 51637 C14orf166 http://www.ncbi.nlm.nih.gov/gene/?term=51637 "CGI-99, CGI99, CLE, CLE7, LCRP369, RLLM1, hCLE1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014830 51637 C14orf166 http://www.ncbi.nlm.nih.gov/gene/?term=51637 "CGI-99, CGI99, CLE, CLE7, LCRP369, RLLM1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014831 51639 SF3B6 http://www.ncbi.nlm.nih.gov/gene/?term=51639 "CGI-110, HSPC175, Ht006, P14, SAP14, SAP14a, SF3B14, SF3B14a " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014832 51639 SF3B6 http://www.ncbi.nlm.nih.gov/gene/?term=51639 "CGI-110, HSPC175, Ht006, P14, SAP14, SAP14a, SF3B14, SF3B14a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014833 5163 PDK1 http://www.ncbi.nlm.nih.gov/gene/?term=5163 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014834 5163 PDK1 http://www.ncbi.nlm.nih.gov/gene/?term=5163 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014835 5163 PDK1 http://www.ncbi.nlm.nih.gov/gene/?term=5163 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014836 5163 PDK1 http://www.ncbi.nlm.nih.gov/gene/?term=5163 mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00014837 51642 MRPL48 http://www.ncbi.nlm.nih.gov/gene/?term=51642 "CGI-118, HSPC290, L48MT, MRP-L48 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014838 51642 MRPL48 http://www.ncbi.nlm.nih.gov/gene/?term=51642 "CGI-118, HSPC290, L48MT, MRP-L48 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014839 51643 TMBIM4 http://www.ncbi.nlm.nih.gov/gene/?term=51643 "CGI-119, GAAP, LFG4, S1R, ZPRO " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014840 51645 PPIL1 http://www.ncbi.nlm.nih.gov/gene/?term=51645 "CGI-124, CYPL1, PPIase, hCyPX " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014841 51646 YPEL5 http://www.ncbi.nlm.nih.gov/gene/?term=51646 CGI-127 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014842 51647 FAM96B http://www.ncbi.nlm.nih.gov/gene/?term=51647 "CGI-128, MIP18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014843 51649 MRPS23 http://www.ncbi.nlm.nih.gov/gene/?term=51649 "CGI-138, HSPC329, MRP-S23 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014844 5164 PDK2 http://www.ncbi.nlm.nih.gov/gene/?term=5164 "PDHK2, PDKII " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014845 5164 PDK2 http://www.ncbi.nlm.nih.gov/gene/?term=5164 "PDHK2, PDKII " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014846 51650 MRPS33 http://www.ncbi.nlm.nih.gov/gene/?term=51650 "CGI-139, MRP-S33, PTD003, S33mt " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014847 51650 MRPS33 http://www.ncbi.nlm.nih.gov/gene/?term=51650 "CGI-139, MRP-S33, PTD003, S33mt " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014848 51651 PTRH2 http://www.ncbi.nlm.nih.gov/gene/?term=51651 "BIT1, CFAP37, CGI-147, IMNEPD, PTH, PTH 2, PTH2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014849 51652 CHMP3 http://www.ncbi.nlm.nih.gov/gene/?term=51652 "CGI-149, NEDF, VPS24 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014850 51652 CHMP3 http://www.ncbi.nlm.nih.gov/gene/?term=51652 "CGI-149, NEDF, VPS24 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014851 51659 GINS2 http://www.ncbi.nlm.nih.gov/gene/?term=51659 "HSPC037, PSF2, Pfs2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014852 51660 MPC1 http://www.ncbi.nlm.nih.gov/gene/?term=51660 "BRP44L, CGI-129, MPYCD, dJ68L15.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014853 51660 MPC1 http://www.ncbi.nlm.nih.gov/gene/?term=51660 "BRP44L, CGI-129, MPYCD, dJ68L15.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014854 51663 ZFR http://www.ncbi.nlm.nih.gov/gene/?term=51663 "SPG711, ZFR " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014855 51663 ZFR http://www.ncbi.nlm.nih.gov/gene/?term=51663 "SPG711, ZFR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014856 51663 ZFR http://www.ncbi.nlm.nih.gov/gene/?term=51663 "SPG71, ZFR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014857 51665 ASB1 http://www.ncbi.nlm.nih.gov/gene/?term=51665 ASB-1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014858 51665 ASB1 http://www.ncbi.nlm.nih.gov/gene/?term=51665 ASB-1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014859 51667 NUB1 http://www.ncbi.nlm.nih.gov/gene/?term=51667 "BS4L, NYREN18, NUB1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014860 51667 NUB1 http://www.ncbi.nlm.nih.gov/gene/?term=51667 "BS4, NUB1L, NYREN18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014861 51668 HSPB11 http://www.ncbi.nlm.nih.gov/gene/?term=51668 "C1orf41, HSPCO34, IFT25, PP25 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014862 51668 HSPB11 http://www.ncbi.nlm.nih.gov/gene/?term=51668 "C1orf41, HSPCO34, IFT25, PP25 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014863 51669 SARAF http://www.ncbi.nlm.nih.gov/gene/?term=51669 "FOAP-7, HSPC035, TMEM66, XTP3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014864 51678 MPP6 http://www.ncbi.nlm.nih.gov/gene/?term=51678 "PALS2, VAM-1, VAM1, p55T " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014865 51678 MPP6 http://www.ncbi.nlm.nih.gov/gene/?term=51678 "PALS2, VAM-1, VAM1, p55T " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014866 5167 ENPP1 http://www.ncbi.nlm.nih.gov/gene/?term=5167 "ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014867 5167 ENPP1 http://www.ncbi.nlm.nih.gov/gene/?term=5167 "ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014868 51690 LSM7 http://www.ncbi.nlm.nih.gov/gene/?term=51690 YNL147W mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014869 51691 LSM8 http://www.ncbi.nlm.nih.gov/gene/?term=51691 NAA38 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014870 51692 CPSF3 http://www.ncbi.nlm.nih.gov/gene/?term=51692 "CPSF-73, CPSF73 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014871 51693 TRAPPC2L http://www.ncbi.nlm.nih.gov/gene/?term=51693 HSPC176 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014872 51696 HECA http://www.ncbi.nlm.nih.gov/gene/?term=51696 "HDC, HDCL, HHDC, dJ225E12.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014873 51696 HECA http://www.ncbi.nlm.nih.gov/gene/?term=51696 "HDC, HDCL, HHDC, dJ225E12.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014874 51696 HECA http://www.ncbi.nlm.nih.gov/gene/?term=51696 "HDC, HDCL, HHDC, dJ225E12.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014875 51699 VPS29 http://www.ncbi.nlm.nih.gov/gene/?term=51699 "DC15, DC7, PEP11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014876 5169 ENPP3 http://www.ncbi.nlm.nih.gov/gene/?term=5169 "B10, CD203c, NPP3, PD-IBETA, PDNP3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014877 516 ATP5G1 http://www.ncbi.nlm.nih.gov/gene/?term=516 "ATP5A, ATP5G " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014878 516 ATP5G1 http://www.ncbi.nlm.nih.gov/gene/?term=516 "ATP5A, ATP5G " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014879 51700 CYB5R2 http://www.ncbi.nlm.nih.gov/gene/?term=51700 B5R.2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014880 51701 NLK http://www.ncbi.nlm.nih.gov/gene/?term=51701 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014881 51701 NLK http://www.ncbi.nlm.nih.gov/gene/?term=51701 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014882 51703 ACSL5 http://www.ncbi.nlm.nih.gov/gene/?term=51703 "ACS2, ACS5, FACL5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014883 51704 GPRC5B http://www.ncbi.nlm.nih.gov/gene/?term=51704 "RAIG-2, RAIG2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014884 51706 CYB5R1 http://www.ncbi.nlm.nih.gov/gene/?term=51706 "B5R.1, B5R1, B5R2, NQO3A2, humb5R2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014885 5170 PDPK1 http://www.ncbi.nlm.nih.gov/gene/?term=5170 "PDK1, PDPK2, PDPK2P, PRO0461 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014886 5170 PDPK1 http://www.ncbi.nlm.nih.gov/gene/?term=5170 "PDK1, PDPK2, PDPK2P, PRO0461 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014887 5170 PDPK1 http://www.ncbi.nlm.nih.gov/gene/?term=5170 "PDK1, PDPK2, PDPK2P, PRO0461 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014888 51714 SELT http://www.ncbi.nlm.nih.gov/gene/?term=51714 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014889 51714 SELT http://www.ncbi.nlm.nih.gov/gene/?term=51714 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014890 51715 RAB23 http://www.ncbi.nlm.nih.gov/gene/?term=51715 HSPC137 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014891 51719 CAB39 http://www.ncbi.nlm.nih.gov/gene/?term=51719 "CGI-66, MO25 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014892 51719 CAB39 http://www.ncbi.nlm.nih.gov/gene/?term=51719 "CGI-66, MO25 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014893 51719 CAB39 http://www.ncbi.nlm.nih.gov/gene/?term=51719 "CGI-66, MO25 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014894 51720 UIMC1 http://www.ncbi.nlm.nih.gov/gene/?term=51720 "RAP80, X2HRIP110 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014895 51726 DNAJB11 http://www.ncbi.nlm.nih.gov/gene/?term=51726 "ABBP-2, ABBP2, DJ9, Dj-9, EDJ, ERdj3, ERj3, ERj3p, PRO1080, UNQ537 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014896 51728 POLR3K http://www.ncbi.nlm.nih.gov/gene/?term=51728 "C11, C11-RNP3, My010, RPC10, RPC11, RPC12.5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014897 51728 POLR3K http://www.ncbi.nlm.nih.gov/gene/?term=51728 "C11, C11-RNP3, My010, RPC10, RPC11, RPC12.5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014898 51728 POLR3K http://www.ncbi.nlm.nih.gov/gene/?term=51728 "C11, C11-RNP3, My010, RPC10, RPC11, RPC12.5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014899 51729 WBP11 http://www.ncbi.nlm.nih.gov/gene/?term=51729 "NPWBP, PPP1R165, SIPP1, WBP-11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014900 51729 WBP11 http://www.ncbi.nlm.nih.gov/gene/?term=51729 "NPWBP, PPP1R165, SIPP1, WBP-11 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014901 5172 SLC26A4 http://www.ncbi.nlm.nih.gov/gene/?term=5172 "DFNB4, EVA, PDS, TDH2B " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014902 5172 SLC26A4 http://www.ncbi.nlm.nih.gov/gene/?term=5172 "DFNB4, EVA, PDS, TDH2B " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014903 51734 MSRB1 http://www.ncbi.nlm.nih.gov/gene/?term=51734 "HSPC270, SELR, SELX, SEPX1, SepR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014904 51741 WWOX http://www.ncbi.nlm.nih.gov/gene/?term=51741 "D16S432E, EIEE28, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014905 51742 ARID4B http://www.ncbi.nlm.nih.gov/gene/?term=51742 "BCAA, BRCAA1, RBBP1L1, RBP1L1, SAP180 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014906 51742 ARID4B http://www.ncbi.nlm.nih.gov/gene/?term=51742 "BCAA, BRCAA1, RBBP1L1, RBP1L1, SAP180 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014907 51747 LUC7L3 http://www.ncbi.nlm.nih.gov/gene/?term=51747 "CRA, CREAP-1, CROP, LUC7A, OA48-18, hLuc7A " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014908 5174 PDZK1 http://www.ncbi.nlm.nih.gov/gene/?term=5174 "CAP70, CLAMP, NHERF-3, NHERF3, PDZD1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014909 5174 PDZK1 http://www.ncbi.nlm.nih.gov/gene/?term=5174 "CAP70, CLAMP, NHERF-3, NHERF3, PDZD1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014910 51752 ERAP1 http://www.ncbi.nlm.nih.gov/gene/?term=51752 "A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP, PILSAP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014911 51755 CDK12 http://www.ncbi.nlm.nih.gov/gene/?term=51755 "CRK7, CRKR, CRKRS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014912 51755 CDK12 http://www.ncbi.nlm.nih.gov/gene/?term=51755 "CRK7, CRKR, CRKRS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014913 51759 C9orf78 http://www.ncbi.nlm.nih.gov/gene/?term=51759 "HCA59, HSPC220, bA409K20.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014914 51759 C9orf78 http://www.ncbi.nlm.nih.gov/gene/?term=51759 "HCA59, HSPC220, bA409K20.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014915 5175 PECAM1 http://www.ncbi.nlm.nih.gov/gene/?term=5175 "CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014916 51762 RAB8B http://www.ncbi.nlm.nih.gov/gene/?term=51762 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014917 51762 RAB8B http://www.ncbi.nlm.nih.gov/gene/?term=51762 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014918 51763 INPP5K http://www.ncbi.nlm.nih.gov/gene/?term=51763 "PPS, SKIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014919 51765 STK26 http://www.ncbi.nlm.nih.gov/gene/?term=51765 "MASK, MST4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014920 51765 STK26 http://www.ncbi.nlm.nih.gov/gene/?term=51765 "MASK, MST4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014921 51768 TM7SF3 http://www.ncbi.nlm.nih.gov/gene/?term=51768 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014922 51768 TM7SF3 http://www.ncbi.nlm.nih.gov/gene/?term=51768 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014923 51773 RSF1 http://www.ncbi.nlm.nih.gov/gene/?term=51773 "HBXAP, RSF-1, XAP8, p325 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014924 51773 RSF1 http://www.ncbi.nlm.nih.gov/gene/?term=51773 "HBXAP, RSF-1, XAP8, p325 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014925 51776 ZAK http://www.ncbi.nlm.nih.gov/gene/?term=51776 "AZK, MLK7, MLT, MLTK, MRK, SFMMP, mlklak, pk " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014926 51780 KDM3B http://www.ncbi.nlm.nih.gov/gene/?term=51780 "5qNCA, C5orf7, JMJD1B, NET22 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014927 51780 KDM3B http://www.ncbi.nlm.nih.gov/gene/?term=51780 "5qNCA, C5orf7, JMJD1B, NET22 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014928 51786 Cpsf2 http://www.ncbi.nlm.nih.gov/gene/?term=51786 "100kDa, 2610024B04Rik, AI662483, Cpsf, MCPSF, mKIAA1367 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014929 51788 H2afz http://www.ncbi.nlm.nih.gov/gene/?term=51788 "H2A.Z, H2a.z-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00014930 51788 H2afz http://www.ncbi.nlm.nih.gov/gene/?term=51788 "H2A.Z, H2a.z-1 " mRNA Mus musculus 25301173 Dendrite Hippocampus In situ hybridization "Figure 2: In situ hybridization reveals species-specific patterns of localization in neuronal dendrites. Fluorescent Microscopy evaluation of biotin-conjugated oligoprobes on paraformaldehyde fixed 14-day cultured rat and mouse cortical neurons hybridized with nine biotin-conjugated oligoprobes detected with streptadivin-Alexa Fluor 568 (Invitrogen). For each probe images set, the small bottom left corner panels represent MAP2 immuno-staining. Scale bar = 20um. (A), Probes against SFRS16, ARHGDIA and HNRPK transcripts show higher dendritic localization in mouse neurons than in rat neurons (Red box). (B), Probes against ZFP410, COMMD3 and RSP6 transcripts show higher dendritic localization in rat neurons than in mouse neurons (Blue box). (C), Probes against UBA52, OLFM1 and H2AFZ transcripts show high dendritic localization in both rat and mouse neurons (Black box). Data are collected from Figure 2. " RLID00014931 51793 Ddah2 http://www.ncbi.nlm.nih.gov/gene/?term=51793 "1110003M04Rik, AU019324, AW413173, DDAH-2, DDAHII, Ddah, G6a, NG30 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014932 51797 Ctps http://www.ncbi.nlm.nih.gov/gene/?term=51797 Ctps1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014933 517 ATP5G2 http://www.ncbi.nlm.nih.gov/gene/?term=517 ATP5A mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014934 517 ATP5G2 http://www.ncbi.nlm.nih.gov/gene/?term=517 ATP5A mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014935 51804 SIX4 http://www.ncbi.nlm.nih.gov/gene/?term=51804 AREC3 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014936 51804 SIX4 http://www.ncbi.nlm.nih.gov/gene/?term=51804 AREC3 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014937 51805 COQ3 http://www.ncbi.nlm.nih.gov/gene/?term=51805 "DHHBMT, DHHBMTASE, UG0215E05, bA9819.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014938 51808 PHAX http://www.ncbi.nlm.nih.gov/gene/?term=51808 RNUXA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014939 51810 Hnrnpu http://www.ncbi.nlm.nih.gov/gene/?term=51810 "AA408410, AI256620, AL024194, AL024437, AW557595, C86794, Hnrpu, SAFA, Sp120, hnRNP U " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014940 51813 Ccnc http://www.ncbi.nlm.nih.gov/gene/?term=51813 "AI451004, AU020987, CG1C " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014941 51816 CECR1 http://www.ncbi.nlm.nih.gov/gene/?term=51816 "ADA2, ADGF, IDGFL, PAN, SNEDS " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014942 51816 CECR1 http://www.ncbi.nlm.nih.gov/gene/?term=51816 "ADA2, ADGF, IDGFL, PAN, SNEDS " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014943 51816 CECR1 http://www.ncbi.nlm.nih.gov/gene/?term=51816 "ADA2, ADGF, IDGFL, PAN, SNEDS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014944 51845 D2Ertd63e http://www.ncbi.nlm.nih.gov/gene/?term=51845 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00014945 5184 PEPD http://www.ncbi.nlm.nih.gov/gene/?term=5184 PROLIDASE mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014946 51864 D2Ertd173e http://www.ncbi.nlm.nih.gov/gene/?term=51864 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00014947 51869 Rif1 http://www.ncbi.nlm.nih.gov/gene/?term=51869 "5730435J01Rik, 6530403D07Rik, AU016181, AW549474, D2Ertd145e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014948 51875 Tmem141 http://www.ncbi.nlm.nih.gov/gene/?term=51875 "1110065P14Rik, AI663999, D2Ertd217e " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014949 51880 D2Ertd239e http://www.ncbi.nlm.nih.gov/gene/?term=51880 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00014950 51885 Tubgcp4 http://www.ncbi.nlm.nih.gov/gene/?term=51885 "4932441P04Rik, 76p, D2Ertd435e, GCP-4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014951 51885 Tubgcp4 http://www.ncbi.nlm.nih.gov/gene/?term=51885 "4932441P04Rik, 76p, D2Ertd435e, GCP-4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00014952 51886 Fubp1 http://www.ncbi.nlm.nih.gov/gene/?term=51886 "9530027K12Rik, D3Ertd330e, FBP, Fubp, Fubp4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014953 5188 GATB http://www.ncbi.nlm.nih.gov/gene/?term=5188 "HSPC199, PET112, PET112L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014954 5189 PEX1 http://www.ncbi.nlm.nih.gov/gene/?term=5189 "HMLR1, PBD1A, PBD1B, ZWS, ZWS1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014955 5189 PEX1 http://www.ncbi.nlm.nih.gov/gene/?term=5189 "HMLR1, PBD1A, PBD1B, ZWS, ZWS1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014956 518 ATP5G3 http://www.ncbi.nlm.nih.gov/gene/?term=518 P3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014957 518 ATP5G3 http://www.ncbi.nlm.nih.gov/gene/?term=518 P3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014958 5190 PEX6 http://www.ncbi.nlm.nih.gov/gene/?term=5190 "HMLR2, PAF-2, PAF2, PBD4A, PDB4B, PXAAA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014959 5191 PEX7 http://www.ncbi.nlm.nih.gov/gene/?term=5191 "PBD9B, PTS2R, RCDP1, RD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014960 5192 PEX10 http://www.ncbi.nlm.nih.gov/gene/?term=5192 "NALD, PBD6A, PBD6B, RNF69 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014961 5193 PEX12 http://www.ncbi.nlm.nih.gov/gene/?term=5193 "PAF-3, PBD3A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014962 51944 Knstrn http://www.ncbi.nlm.nih.gov/gene/?term=51944 "1700025D04Rik, C15orf23, D2Ertd750e, SKAP, Traf4af1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014963 5194 PEX13 http://www.ncbi.nlm.nih.gov/gene/?term=5194 "NALD, PBD11A, PBD11B, ZWS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014964 5194 PEX13 http://www.ncbi.nlm.nih.gov/gene/?term=5194 "NALD, PBD11A, PBD11B, ZWS " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014965 5194 PEX13 http://www.ncbi.nlm.nih.gov/gene/?term=5194 "NALD, PBD11A, PBD11B, ZWS " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014966 5194 PEX13 http://www.ncbi.nlm.nih.gov/gene/?term=5194 "NALD, PBD11A, PBD11B, ZWS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014967 5195 PEX14 http://www.ncbi.nlm.nih.gov/gene/?term=5195 "NAPP2, PBD13A, Pex14p, dJ734G22.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014968 51960 Kctd18 http://www.ncbi.nlm.nih.gov/gene/?term=51960 "4932411A20Rik, 6530404F10Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014969 5198 PFAS http://www.ncbi.nlm.nih.gov/gene/?term=5198 "FGAMS, FGAR-AT, FGARAT, PURL " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014970 5198 PFAS http://www.ncbi.nlm.nih.gov/gene/?term=5198 "FGAMS, FGAR-AT, FGARAT, PURL " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014971 5198 PFAS http://www.ncbi.nlm.nih.gov/gene/?term=5198 "FGAMS, FGAR-AT, FGARAT, PURL " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014972 51 ACOX1 http://www.ncbi.nlm.nih.gov/gene/?term=51 "ACOX, PALMCOX, SCOX " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014973 51 ACOX1 http://www.ncbi.nlm.nih.gov/gene/?term=51 "ACOX, PALMCOX, SCOX " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014974 51 ACOX1 http://www.ncbi.nlm.nih.gov/gene/?term=51 "ACOX, PALMCOX, SCOX " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014975 51 ACOX1 http://www.ncbi.nlm.nih.gov/gene/?term=51 "ACOX, PALMCOX, SCOX " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00014976 51 ACOX1 http://www.ncbi.nlm.nih.gov/gene/?term=51 "ACOX, PALMCOX, SCOX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014977 52004 Cdk2ap2 http://www.ncbi.nlm.nih.gov/gene/?term=52004 "5830466O21Rik, D19Ertd144e, Doc-1r " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014978 52013 R3hcc1l http://www.ncbi.nlm.nih.gov/gene/?term=52013 "1700036B12Rik, AI450607, C10orf28, D19Ertd386e, GIDRP86, Gidrp88 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014979 5201 PFDN1 http://www.ncbi.nlm.nih.gov/gene/?term=5201 "PDF, PFD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014980 52020 Umodl1 http://www.ncbi.nlm.nih.gov/gene/?term=52020 D17Ertd488e mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014981 5202 PFDN2 http://www.ncbi.nlm.nih.gov/gene/?term=5202 PFD2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014982 52033 Pbk http://www.ncbi.nlm.nih.gov/gene/?term=52033 "2810434B10Rik, AW538537, D14Ertd732e, TOPK " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014983 52036 Ppp6r3 http://www.ncbi.nlm.nih.gov/gene/?term=52036 "4930528G08Rik, 9130026N02Rik, D19Bwg1430e, D19Ertd703e, Pp6r3, Ppcs3, Pptcs3, Sapl, Saps3, mKIAA1558 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014984 5203 PFDN4 http://www.ncbi.nlm.nih.gov/gene/?term=5203 "C1, PFD4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014985 5204 PFDN5 http://www.ncbi.nlm.nih.gov/gene/?term=5204 "MM-1, MM1, PFD5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014986 5204 PFDN5 http://www.ncbi.nlm.nih.gov/gene/?term=5204 "MM-1, MM1, PFD5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014987 5204 PFDN5 http://www.ncbi.nlm.nih.gov/gene/?term=5204 "MM-1, MM1, PFD5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014988 5205 ATP8B1 http://www.ncbi.nlm.nih.gov/gene/?term=5205 "ATPIC, BRIC, FIC1, ICP1, PFIC, PFIC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014989 5207 PFKFB1 http://www.ncbi.nlm.nih.gov/gene/?term=5207 "F6PK, HL2K, PFRX " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014990 5208 PFKFB2 http://www.ncbi.nlm.nih.gov/gene/?term=5208 PFK-2/FBPase-2 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014991 5208 PFKFB2 http://www.ncbi.nlm.nih.gov/gene/?term=5208 PFK-2/FBPase-2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014992 5209 PFKFB3 http://www.ncbi.nlm.nih.gov/gene/?term=5209 "IPFK2, PFK2, iPFK-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014993 5209 PFKFB3 http://www.ncbi.nlm.nih.gov/gene/?term=5209 "IPFK2, PFK2, iPFK-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014994 5210 PFKFB4 http://www.ncbi.nlm.nih.gov/gene/?term=5210 mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00014995 5211 PFKL http://www.ncbi.nlm.nih.gov/gene/?term=5211 "ATP-PFK, PFK-B, PFK-L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00014996 5211 PFKL http://www.ncbi.nlm.nih.gov/gene/?term=5211 "ATP-PFK, PFK-B, PFK-L " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00014997 5211 PFKL http://www.ncbi.nlm.nih.gov/gene/?term=5211 "ATP-PFK, PFK-B, PFK-L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00014998 52120 Hgsnat http://www.ncbi.nlm.nih.gov/gene/?term=52120 "9430010M12Rik, AW208455, D8Ertd354e, Tmem76 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00014999 52123 Agpat5 http://www.ncbi.nlm.nih.gov/gene/?term=52123 "1110013A05Rik, D8Ertd319e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015000 5213 PFKM http://www.ncbi.nlm.nih.gov/gene/?term=5213 "ATP-PFK, GSD7, PFK-1, PFK1, PFKA, PFKX, PPP1R122 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015001 5213 PFKM http://www.ncbi.nlm.nih.gov/gene/?term=5213 "ATP-PFK, GSD7, PFK-1, PFK1, PFKA, PFKX, PPP1R122 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015002 5213 PFKM http://www.ncbi.nlm.nih.gov/gene/?term=5213 "ATP-PFK, GSD7, PFK-1, PFK1, PFKA, PFKX, PPP1R122 " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00015003 5213 PFKM http://www.ncbi.nlm.nih.gov/gene/?term=5213 "ATP-PFK, GSD7, PFK-1, PFK1, PFKA, PFKX, PPP1R122 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015004 5214 PFKP http://www.ncbi.nlm.nih.gov/gene/?term=5214 "ATP-PFK, PFK-C, PFK-P, PFKF " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015005 5214 PFKP http://www.ncbi.nlm.nih.gov/gene/?term=5214 "ATP-PFK, PFK-C, PFK-P, PFKF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015006 52164 D4Ertd117e http://www.ncbi.nlm.nih.gov/gene/?term=52164 D4Ertd41e mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015007 5216 PFN1 http://www.ncbi.nlm.nih.gov/gene/?term=5216 ALS18 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015008 5216 PFN1 http://www.ncbi.nlm.nih.gov/gene/?term=5216 ALS18 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015009 5216 PFN1 http://www.ncbi.nlm.nih.gov/gene/?term=5216 ALS18 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015010 5217 PFN2 http://www.ncbi.nlm.nih.gov/gene/?term=5217 "D3S1319E, PFL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015011 52184 Odf2l http://www.ncbi.nlm.nih.gov/gene/?term=52184 "4733401D09Rik, 9630045K08Rik, D3Ertd250e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015012 5218 CDK14 http://www.ncbi.nlm.nih.gov/gene/?term=5218 "PFTAIRE1, PFTK1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015013 5218 CDK14 http://www.ncbi.nlm.nih.gov/gene/?term=5218 "PFTAIRE1, PFTK1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015014 5218 CDK14 http://www.ncbi.nlm.nih.gov/gene/?term=5218 "PFTAIRE1, PFTK1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015015 521 ATP5I http://www.ncbi.nlm.nih.gov/gene/?term=521 ATP5K mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015016 521 ATP5I http://www.ncbi.nlm.nih.gov/gene/?term=521 ATP5K mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015017 52223 D6Ertd160e http://www.ncbi.nlm.nih.gov/gene/?term=52223 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015018 5223 PGAM1 http://www.ncbi.nlm.nih.gov/gene/?term=5223 "HEL-S-35, PGAM-B, PGAMA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015019 52252 D3Ertd162e http://www.ncbi.nlm.nih.gov/gene/?term=52252 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015020 5226 PGD http://www.ncbi.nlm.nih.gov/gene/?term=5226 6PGD mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015021 5228 PGF http://www.ncbi.nlm.nih.gov/gene/?term=5228 "D12S1900, PGFL, PLGF, PlGF-2, SHGC-10760 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015022 522 ATP5J http://www.ncbi.nlm.nih.gov/gene/?term=522 "ATP5, ATP5A, ATPM, CF6, F6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015023 522 ATP5J http://www.ncbi.nlm.nih.gov/gene/?term=522 "ATP5, ATP5A, ATPM, CF6, F6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015024 5230 PGK1 http://www.ncbi.nlm.nih.gov/gene/?term=5230 "HEL-S-68p, MIG10, PGKA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015025 5230 PGK1 http://www.ncbi.nlm.nih.gov/gene/?term=5230 "HEL-S-68p, MIG10, PGKA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015026 5230 PGK1 http://www.ncbi.nlm.nih.gov/gene/?term=5230 "HEL-S-68p, MIG10, PGKA " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00015027 5230 PGK1 http://www.ncbi.nlm.nih.gov/gene/?term=5230 "HEL-S-68p, MIG10, PGKA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015028 52331 Stbd1 http://www.ncbi.nlm.nih.gov/gene/?term=52331 "D530019K15Rik, D5Ertd593e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015029 5236 PGM1 http://www.ncbi.nlm.nih.gov/gene/?term=5236 "CDG1T, GSD14 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015030 5236 PGM1 http://www.ncbi.nlm.nih.gov/gene/?term=5236 "CDG1T, GSD14 " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00015031 5236 PGM1 http://www.ncbi.nlm.nih.gov/gene/?term=5236 "CDG1T, GSD14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015032 5238 PGM3 http://www.ncbi.nlm.nih.gov/gene/?term=5238 "AGM1, IMD23, PAGM, PGM 3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015033 5238 PGM3 http://www.ncbi.nlm.nih.gov/gene/?term=5238 "AGM1, IMD23, PAGM, PGM 3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015034 52398 Sept11 http://www.ncbi.nlm.nih.gov/gene/?term=52398 "6230410I01Rik, AW548875, D5Ertd606e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015035 523 ATP6V1A http://www.ncbi.nlm.nih.gov/gene/?term=523 "ATP6A11, HO68, VA68, VPP2, Vma1, ATP6V1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015036 523 ATP6V1A http://www.ncbi.nlm.nih.gov/gene/?term=523 "ATP6A1, ATP6V1A1, HO68, VA68, VPP2, Vma1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015037 5243 ABCB1 http://www.ncbi.nlm.nih.gov/gene/?term=5243 "ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 " mRNA Homo sapiens 20453113 Endoplasmic reticulum NCI/ADR-RES cell qRT-PCR "The relative partitioning of both cytosolic (ACTB, H3.3) and ER-bound (MDR1, CANX) transcripts between both fractions was marked, despite the small carryover of cytosol in the ER fraction (Fig. 2B). Polysome profile analyses from the isolated fractions indicated that these transcripts migrated in polyribosome-containing fractions (Fig. 2C). Notably, the distribution of ER-bound transcripts between the ER and cytosol did not change on arsenite treatment of NCI/ADR-RES cells (Fig. 2D). Data are collected from Figure 2. " RLID00015038 5243 ABCB1 http://www.ncbi.nlm.nih.gov/gene/?term=5243 "ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 " mRNA Homo sapiens 20453113 Ribosome NCI/ADR-RES cell qRT-PCR "The relative partitioning of both cytosolic (ACTB, H3.3) and ER-bound (MDR1, CANX) transcripts between both fractions was marked, despite the small carryover of cytosol in the ER fraction (Fig. 2B). Polysome profile analyses from the isolated fractions indicated that these transcripts migrated in polyribosome-containing fractions (Fig. 2C). Notably, the distribution of ER-bound transcripts between the ER and cytosol did not change on arsenite treatment of NCI/ADR-RES cells (Fig. 2D). Data are collected from Figure 2. " RLID00015039 52440 Tax1bp1 http://www.ncbi.nlm.nih.gov/gene/?term=52440 "1200003J11Rik, 1700069J21Rik, AA930106, D6Ertd404e, D6Ertd772e, T6bp, TXBP151 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015040 52455 D11Ertd49e http://www.ncbi.nlm.nih.gov/gene/?term=52455 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015041 5245 PHB http://www.ncbi.nlm.nih.gov/gene/?term=5245 "HEL-215, HEL-S-54e1, PHB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015042 5245 PHB http://www.ncbi.nlm.nih.gov/gene/?term=5245 "HEL-215, HEL-S-54e, PHB1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015043 52463 Tet1 http://www.ncbi.nlm.nih.gov/gene/?term=52463 "2510010B09Rik, AA517754, BB001228, Cxxc6, D10Ertd17e, LCX, mKIAA1676 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015044 52480 Snhg14 http://www.ncbi.nlm.nih.gov/gene/?term=52480 "AU018661, D7Ertd715e, Lncat " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015045 52480 Snhg14 http://www.ncbi.nlm.nih.gov/gene/?term=52480 "AU018661, D7Ertd715e, Lncat " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015046 52495 D12Ertd208e http://www.ncbi.nlm.nih.gov/gene/?term=52495 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015047 52502 Carhsp1 http://www.ncbi.nlm.nih.gov/gene/?term=52502 "1200011K09Rik, Crhsp-24, D16Ertd465e " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015048 5250 SLC25A3 http://www.ncbi.nlm.nih.gov/gene/?term=5250 "OK/SW-cl.48, PHC, PTP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015049 5250 SLC25A3 http://www.ncbi.nlm.nih.gov/gene/?term=5250 "OK/SW-cl.48, PHC, PTP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015050 5252 PHF1 http://www.ncbi.nlm.nih.gov/gene/?term=5252 "MTF2L2, PCL1, PHF2, TDRD19C, hPHF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015051 52538 Acaa2 http://www.ncbi.nlm.nih.gov/gene/?term=52538 "0610011L04Rik, AI255831, AI265397, D18Ertd240e " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015052 52538 Acaa2 http://www.ncbi.nlm.nih.gov/gene/?term=52538 "0610011L04Rik, AI255831, AI265397, D18Ertd240e " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00015053 52552 Parp8 http://www.ncbi.nlm.nih.gov/gene/?term=52552 "2810430O08Rik, ARTD16, D13Ertd275e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015054 52563 Cdc23 http://www.ncbi.nlm.nih.gov/gene/?term=52563 "6030435O18, D18Ertd243e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015055 52565 D12Ertd125e http://www.ncbi.nlm.nih.gov/gene/?term=52565 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015056 5256 PHKA2 http://www.ncbi.nlm.nih.gov/gene/?term=5256 "GSD9A, PHK, PYK, PYKL, XLG, XLG2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015057 52575 Trmt10c http://www.ncbi.nlm.nih.gov/gene/?term=52575 "1300018J16Rik, D16Ertd454e, Rg9mtd1, Rnmtd1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015058 5257 PHKB http://www.ncbi.nlm.nih.gov/gene/?term=5257 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015059 52585 Dhrs1 http://www.ncbi.nlm.nih.gov/gene/?term=52585 "1110029G07Rik, AW112170, D14Ertd484e " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015060 525 ATP6V1B1 http://www.ncbi.nlm.nih.gov/gene/?term=525 "ATP6B1, RTA1B, VATB, VMA2, VPP3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015061 5260 PHKG1 http://www.ncbi.nlm.nih.gov/gene/?term=5260 PHKG mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015062 52615 Suz12 http://www.ncbi.nlm.nih.gov/gene/?term=52615 "2610028O16Rik, AI195385, AU016842, AW536442, D11Ertd530e, mKIAA0160 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015063 5261 PHKG2 http://www.ncbi.nlm.nih.gov/gene/?term=5261 GSD9C mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015064 5261 PHKG2 http://www.ncbi.nlm.nih.gov/gene/?term=5261 GSD9C mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015065 52635 Esyt2 http://www.ncbi.nlm.nih.gov/gene/?term=52635 "2410017M09Rik, 4921504I16Rik, CHR2SYT, D12Ertd551e, Fam62b " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015066 52639 Wipi1 http://www.ncbi.nlm.nih.gov/gene/?term=52639 "4930533H01Rik, AW411817, D11Ertd498e " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015067 5264 PHYH http://www.ncbi.nlm.nih.gov/gene/?term=5264 "LN1, LNAP1, PAHX1, RD, PHYH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015068 5264 PHYH http://www.ncbi.nlm.nih.gov/gene/?term=5264 "LN1, LNAP1, PAHX, PHYH1, RD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015069 52653 Nudcd2 http://www.ncbi.nlm.nih.gov/gene/?term=52653 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015070 5265 SERPINA1 http://www.ncbi.nlm.nih.gov/gene/?term=5265 "A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015071 52665 Echdc1 http://www.ncbi.nlm.nih.gov/gene/?term=52665 "1700028A24Rik, AI314462, AI930038, D10Ertd667e, MMCD " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015072 526937 DCXR http://www.ncbi.nlm.nih.gov/gene/?term=526937 mRNA Bos taurus 25815750 Cytoplasm Epithelial cell qRT-PCR|In situ hybridization "In situ hybridization was used to localize the DCXR gene expression pattern at the histological level. In agreement with the PCR results, antisense DCXR cRNA hybridization increases from the caput to the cauda epididymidis, with expression being in the majority, located to the epithelial cells. Some faint staining can be found in some blood vessels endothelial cells (S1 Fig.). The mRNA is uniformly located in the cytoplasm of caput epithelial cells (Fig. 3A). " RLID00015073 5269 SERPINB6 http://www.ncbi.nlm.nih.gov/gene/?term=5269 "CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015074 5269 SERPINB6 http://www.ncbi.nlm.nih.gov/gene/?term=5269 "CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015075 5269 SERPINB6 http://www.ncbi.nlm.nih.gov/gene/?term=5269 "CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015076 526 ATP6V1B2 http://www.ncbi.nlm.nih.gov/gene/?term=526 "ATP6B1B2, ATP6B2, HO57, VATB, VPP3, Vma2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015077 526 ATP6V1B2 http://www.ncbi.nlm.nih.gov/gene/?term=526 "ATP6B1B2, ATP6B2, HO57, VATB, VPP3, Vma2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015078 52704 D11Ertd717e http://www.ncbi.nlm.nih.gov/gene/?term=52704 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015079 52705 Krr1 http://www.ncbi.nlm.nih.gov/gene/?term=52705 "2610511F02Rik, AI255219, AI428520, D10Ertd773e, Hrb2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015080 5270 SERPINE2 http://www.ncbi.nlm.nih.gov/gene/?term=5270 "GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015081 5270 SERPINE2 http://www.ncbi.nlm.nih.gov/gene/?term=5270 "GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015082 5270 SERPINE2 http://www.ncbi.nlm.nih.gov/gene/?term=5270 "GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015083 5272 SERPINB9 http://www.ncbi.nlm.nih.gov/gene/?term=5272 "CAP-3, CAP3, PI-9, PI9 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015084 5272 SERPINB9 http://www.ncbi.nlm.nih.gov/gene/?term=5272 "CAP-3, CAP3, PI-9, PI9 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015085 5272 SERPINB9 http://www.ncbi.nlm.nih.gov/gene/?term=5272 "CAP-3, CAP3, PI-9, PI9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015086 5274 SERPINI1 http://www.ncbi.nlm.nih.gov/gene/?term=5274 "PI12, neuroserpin " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015087 5277 PIGA http://www.ncbi.nlm.nih.gov/gene/?term=5277 "GPI3, MCAHS2, PIG-A, PNH1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015088 5277 PIGA http://www.ncbi.nlm.nih.gov/gene/?term=5277 "GPI3, MCAHS2, PIG-A, PNH1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015089 5279 PIGC http://www.ncbi.nlm.nih.gov/gene/?term=5279 GPI2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015090 5279 PIGC http://www.ncbi.nlm.nih.gov/gene/?term=5279 GPI2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015091 5279 PIGC http://www.ncbi.nlm.nih.gov/gene/?term=5279 GPI2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015092 527 ATP6V0C http://www.ncbi.nlm.nih.gov/gene/?term=527 "ATP6C, ATP6L, ATPL, VATL, VPPC, Vma3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015093 52808 Tspyl2 http://www.ncbi.nlm.nih.gov/gene/?term=52808 "CDA1, CINAP, DENTT, DXBwg1396e, DXHXS1008E, E130307F10Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015094 5281 PIGF http://www.ncbi.nlm.nih.gov/gene/?term=5281 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015095 5281 PIGF http://www.ncbi.nlm.nih.gov/gene/?term=5281 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015096 52822 Rufy3 http://www.ncbi.nlm.nih.gov/gene/?term=52822 "2810428M05Rik, 6330416M07Rik, AW455998, AW538594, D5Bwg0860e, Ripx, Rpipx " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015097 52837 Tmx4 http://www.ncbi.nlm.nih.gov/gene/?term=52837 "2810417D04Rik, 4930500L08Rik, AI843224, AW046784, D2Bwg1356e, Txndc13, mKIAA1162 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015098 52838 Dnlz http://www.ncbi.nlm.nih.gov/gene/?term=52838 "1110034G11Rik, D2Bwg1335e, HEP1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015099 5283 PIGH http://www.ncbi.nlm.nih.gov/gene/?term=5283 GPI-H mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015100 52840 Dbndd2 http://www.ncbi.nlm.nih.gov/gene/?term=52840 "1110017A21Rik, 2900022J10Rik, AU041050, AW048677, D2Bwg0891e, Nkip, R74724 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015101 5284 PIGR http://www.ncbi.nlm.nih.gov/gene/?term=5284 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015102 5284 PIGR http://www.ncbi.nlm.nih.gov/gene/?term=5284 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015103 5284 PIGR http://www.ncbi.nlm.nih.gov/gene/?term=5284 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015104 52856 Mtg2 http://www.ncbi.nlm.nih.gov/gene/?term=52856 "1810011P19Rik, 2900056P18Rik, D2Bwg0647e, Gtpbp5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015105 52856 Mtg2 http://www.ncbi.nlm.nih.gov/gene/?term=52856 "1810011P19Rik, 2900056P18Rik, D2Bwg0647e, Gtpbp5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015106 5286 PIK3C2A http://www.ncbi.nlm.nih.gov/gene/?term=5286 "CPK, PI3-K-C2(ALPHA), PI3-K-C2A, PI3K-C2-alpha, PI3K-C2alpha " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015107 5286 PIK3C2A http://www.ncbi.nlm.nih.gov/gene/?term=5286 "CPK, PI3-K-C2(ALPHA), PI3-K-C2A, PI3K-C2-alpha, PI3K-C2alpha " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015108 5286 PIK3C2A http://www.ncbi.nlm.nih.gov/gene/?term=5286 "CPK, PI3-K-C2(ALPHA), PI3-K-C2A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015109 5287 PIK3C2B http://www.ncbi.nlm.nih.gov/gene/?term=5287 C2-PI3K mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015110 5287 PIK3C2B http://www.ncbi.nlm.nih.gov/gene/?term=5287 C2-PI3K mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015111 5287 PIK3C2B http://www.ncbi.nlm.nih.gov/gene/?term=5287 C2-PI3K mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015112 5289 PIK3C3 http://www.ncbi.nlm.nih.gov/gene/?term=5289 "VPS34, Vps34, hVps34 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015113 528 ATP6V1C1 http://www.ncbi.nlm.nih.gov/gene/?term=528 "ATP6C, ATP6D, VATC, Vma5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015114 528 ATP6V1C1 http://www.ncbi.nlm.nih.gov/gene/?term=528 "ATP6C, ATP6D, VATC, Vma5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015115 52902 D10Bwg1070e http://www.ncbi.nlm.nih.gov/gene/?term=52902 5730421K10Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015116 52906 Ahi1 http://www.ncbi.nlm.nih.gov/gene/?term=52906 "1700015F03Rik, Ahi-1, D10Bwg0629e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015117 5290 PIK3CA http://www.ncbi.nlm.nih.gov/gene/?term=5290 "CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015118 5290 PIK3CA http://www.ncbi.nlm.nih.gov/gene/?term=5290 "CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015119 5291 PIK3CB http://www.ncbi.nlm.nih.gov/gene/?term=5291 "P110BETA, PI3K, PI3KBETA, PIK3C1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015120 5292 PIM1 http://www.ncbi.nlm.nih.gov/gene/?term=5292 PIM mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015121 5292 PIM1 http://www.ncbi.nlm.nih.gov/gene/?term=5292 PIM mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015122 5292 PIM1 http://www.ncbi.nlm.nih.gov/gene/?term=5292 PIM mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015123 5292 PIM1 http://www.ncbi.nlm.nih.gov/gene/?term=5292 PIM mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015124 5292 PIM1 http://www.ncbi.nlm.nih.gov/gene/?term=5292 PIM mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015125 5293 PIK3CD http://www.ncbi.nlm.nih.gov/gene/?term=5293 "APDS, IMD14, P110DELTA, PI3K, p110D " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015126 5293 PIK3CD http://www.ncbi.nlm.nih.gov/gene/?term=5293 "APDS, IMD14, P110DELTA, PI3K, p110D " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015127 5293 PIK3CD http://www.ncbi.nlm.nih.gov/gene/?term=5293 "APDS, IMD14, P110DELTA, PI3K, p110D " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015128 5294 PIK3CG http://www.ncbi.nlm.nih.gov/gene/?term=5294 "PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015129 5295 PIK3R1 http://www.ncbi.nlm.nih.gov/gene/?term=5295 "AGM7, GRB1, IMD36, p85, p85-ALPHA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015130 5295 PIK3R1 http://www.ncbi.nlm.nih.gov/gene/?term=5295 "AGM7, GRB1, IMD36, p85, p85-ALPHA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015131 5295 PIK3R1 http://www.ncbi.nlm.nih.gov/gene/?term=5295 "AGM7, GRB1, IMD36, p85, p85-ALPHA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015132 5296 PIK3R2 http://www.ncbi.nlm.nih.gov/gene/?term=5296 "MPPH, MPPH1, P85B, p85, p85-BETA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015133 5297 PI4KA http://www.ncbi.nlm.nih.gov/gene/?term=5297 "PI4K-ALPHA, PIK4CA, PMGYCHA, pi4K230 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015134 5298 PI4KB http://www.ncbi.nlm.nih.gov/gene/?term=5298 "NPIK, PI4K-BETA, PI4K92ETA, PI4KIIIBETA, PIK4CB, PI4KB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015135 5298 PI4KB http://www.ncbi.nlm.nih.gov/gene/?term=5298 "NPIK, PI4K-BETA, PI4K92, PI4KBETA, PI4KIIIBETA, PIK4CB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015136 529 ATP6V1E1 http://www.ncbi.nlm.nih.gov/gene/?term=529 "ATP6E, ATP6E2, ATP6V1E, P31, Vma4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015137 52 ACP1 http://www.ncbi.nlm.nih.gov/gene/?term=52 "HAAP, LMW-PTP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015138 5300 PIN1 http://www.ncbi.nlm.nih.gov/gene/?term=5300 "DOD, UBL5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015139 5301 PIN1P1 http://www.ncbi.nlm.nih.gov/gene/?term=5301 PIN1L lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015140 5303 PIN4 http://www.ncbi.nlm.nih.gov/gene/?term=5303 "EPVH, PAR14, PAR17 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015141 5303 PIN4 http://www.ncbi.nlm.nih.gov/gene/?term=5303 "EPVH, PAR14, PAR17 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015142 5305 PIP4K2A http://www.ncbi.nlm.nih.gov/gene/?term=5305 "PI5P4KA, PIP5K2A, PIP5KII-alpha, PIP5KIIA, PIPK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015143 5306 PITPNA http://www.ncbi.nlm.nih.gov/gene/?term=5306 "HEL-S-36, PI-TPalpha, PITPN, VIB1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015144 5306 PITPNA http://www.ncbi.nlm.nih.gov/gene/?term=5306 "HEL-S-36, PI-TPalpha, PITPN, VIB1A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015145 5306 PITPNA http://www.ncbi.nlm.nih.gov/gene/?term=5306 "HEL-S-36, PI-TPalpha, PITPN, VIB1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015146 5307 PITX1 http://www.ncbi.nlm.nih.gov/gene/?term=5307 "BFT, CCF, LBNBG, POTX, PTX1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015147 5310 PKD1 http://www.ncbi.nlm.nih.gov/gene/?term=5310 "PBP, Pc-1, TRPP1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015148 5311 PKD2 http://www.ncbi.nlm.nih.gov/gene/?term=5311 "APKD2, PC2, PKD4, Pc-2, TRPP2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015149 5313 PKLR http://www.ncbi.nlm.nih.gov/gene/?term=5313 "PK1, PKL, PKR, PKRL, RPK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015150 5315 PKM http://www.ncbi.nlm.nih.gov/gene/?term=5315 "CTHBP, HEL-S-30, OIP3, PK32, TCB, THBP1, PKM " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015151 5316 PKNOX1 http://www.ncbi.nlm.nih.gov/gene/?term=5316 "PREP1, pkonx1c " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015152 5316 PKNOX1 http://www.ncbi.nlm.nih.gov/gene/?term=5316 "PREP1, pkonx1c " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015153 5316 PKNOX1 http://www.ncbi.nlm.nih.gov/gene/?term=5316 "PREP1, pkonx1c " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015154 5316 PKNOX1 http://www.ncbi.nlm.nih.gov/gene/?term=5316 "PREP1, pkonx1c " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015155 5316 PKNOX1 http://www.ncbi.nlm.nih.gov/gene/?term=5316 "PREP1, pkonx1c " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015156 5318 PKP2 http://www.ncbi.nlm.nih.gov/gene/?term=5318 ARVD9 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015157 5320 PLA2G2A http://www.ncbi.nlm.nih.gov/gene/?term=5320 "MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015158 5325 PLAGL1 http://www.ncbi.nlm.nih.gov/gene/?term=5325 "LOT1, ZAC, ZAC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015159 5326 PLAGL2 http://www.ncbi.nlm.nih.gov/gene/?term=5326 ZNF900 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015160 5326 PLAGL2 http://www.ncbi.nlm.nih.gov/gene/?term=5326 ZNF900 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015161 5327 PLAT http://www.ncbi.nlm.nih.gov/gene/?term=5327 "T-PA, TPA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015162 5328 PLAU http://www.ncbi.nlm.nih.gov/gene/?term=5328 "ATF, BDPLT5, QPD, UPA, URK, u-PA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015163 5329 PLAUR http://www.ncbi.nlm.nih.gov/gene/?term=5329 "CD87, U-PAR, UPAR, URKR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015164 5330 PLCB2 http://www.ncbi.nlm.nih.gov/gene/?term=5330 PLC-beta-2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015165 53312 Nub1 http://www.ncbi.nlm.nih.gov/gene/?term=53312 "4931404D21Rik, 6330412F12Rik, BS4, NY-REN-18 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015166 53319 Nxf1 http://www.ncbi.nlm.nih.gov/gene/?term=53319 "Mex67, Mvb1, Tap " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015167 5331 PLCB3 http://www.ncbi.nlm.nih.gov/gene/?term=5331 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015168 53320 Folh1 http://www.ncbi.nlm.nih.gov/gene/?term=53320 "GCP2, mopsm " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015169 53322 Nucb2 http://www.ncbi.nlm.nih.gov/gene/?term=53322 "AI607786, Calnuc, Nefa, Nesfatin-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015170 53328 Pgrmc1 http://www.ncbi.nlm.nih.gov/gene/?term=53328 "AA415812, HPR6.6, PPMR, Vema " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015171 53334 Gosr1 http://www.ncbi.nlm.nih.gov/gene/?term=53334 "AI414660, AI426320, BB145494, GOS-28, GOSRI, GS28 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015172 53339 BTBD1 http://www.ncbi.nlm.nih.gov/gene/?term=53339 "C15orf1, NS5ATP8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015173 53339 BTBD1 http://www.ncbi.nlm.nih.gov/gene/?term=53339 "C15orf1, NS5ATP8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015174 53339 BTBD1 http://www.ncbi.nlm.nih.gov/gene/?term=53339 "C15orf1, NS5ATP8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015175 5333 PLCD1 http://www.ncbi.nlm.nih.gov/gene/?term=5333 "NDNC3, PLC-III " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015176 53340 SPA17 http://www.ncbi.nlm.nih.gov/gene/?term=53340 "CT22, SP17, SP17-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015177 53349 ZFYVE1 http://www.ncbi.nlm.nih.gov/gene/?term=53349 "DFCP1, PPP1R172, SR3, TAFF1, ZNFN2A1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015178 5334 PLCL1 http://www.ncbi.nlm.nih.gov/gene/?term=5334 "PLCE, PLCL, PLDL1, PPP1R127, PRIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015179 53354 PANK1 http://www.ncbi.nlm.nih.gov/gene/?term=53354 PANK mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015180 53357 Pla2g6 http://www.ncbi.nlm.nih.gov/gene/?term=53357 "BB112799, PNPLA9, iPLA(2)beta, iPLA2, iPLA2beta " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015181 5335 PLCG1 http://www.ncbi.nlm.nih.gov/gene/?term=5335 "NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015182 5336 PLCG2 http://www.ncbi.nlm.nih.gov/gene/?term=5336 "APLAID, FCAS3, PLC-IV, PLC-gamma-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015183 53371 NUP54 http://www.ncbi.nlm.nih.gov/gene/?term=53371 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015184 53375 Mtx2 http://www.ncbi.nlm.nih.gov/gene/?term=53375 1500012G02Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015185 53378 Sdcbp http://www.ncbi.nlm.nih.gov/gene/?term=53378 "MDA-9, Sycl, syntenin-1 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015186 53378 Sdcbp http://www.ncbi.nlm.nih.gov/gene/?term=53378 "MDA-9, Sycl, syntenin-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015187 53379 Hnrnpa2b1 http://www.ncbi.nlm.nih.gov/gene/?term=53379 "9130414A06Rik, Hnrpa2, Hnrpa2b1, hnrnp-A " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015188 5338 PLD2 http://www.ncbi.nlm.nih.gov/gene/?term=5338 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015189 5339 PLEC http://www.ncbi.nlm.nih.gov/gene/?term=5339 "EBS1, EBSMD, EBSND, EBSO, EBSOG, EBSPA, HD1, LGMD2Q, PCN1, PLEC1b, PLTN, PLEC " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015190 5339 PLEC http://www.ncbi.nlm.nih.gov/gene/?term=5339 "EBS1, EBSMD, EBSND, EBSO, EBSOG, EBSPA, HD1, LGMD2Q, PCN, PLEC1, PLEC1b, PLTN " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015191 533 ATP6V0B http://www.ncbi.nlm.nih.gov/gene/?term=533 "ATP6F, HATPL, VMA16 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015192 533 ATP6V0B http://www.ncbi.nlm.nih.gov/gene/?term=533 "ATP6F, HATPL, VMA16 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015193 53407 STX18 http://www.ncbi.nlm.nih.gov/gene/?term=53407 Ufe1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015194 53414 Bysl http://www.ncbi.nlm.nih.gov/gene/?term=53414 "Bys, Enp1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015195 53418 B4galt2 http://www.ncbi.nlm.nih.gov/gene/?term=53418 Ggtb2 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015196 53421 Sec61a1 http://www.ncbi.nlm.nih.gov/gene/?term=53421 "AA408394, AA410007, Sec61a " mRNA Mus musculus 12923260 Ribosome B cell S1 nuclease protection assays "Using the procedures described above, the subcellular distribution of individual mRNAs in the cytosol and rough ER polysome fractions of Jurkat and J558 cells was determined. As depicted in Figure 4, Sec61a and calnexin were highly enriched in the membrane-bound fraction, as may be predicted for those mRNAs encoding signal sequences. " RLID00015197 53421 Sec61a1 http://www.ncbi.nlm.nih.gov/gene/?term=53421 "Sec61a, AA408394, AA410007 " mRNA Mus musculus 12923260 Ribosome J558 cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 μg of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00015198 5342 PLGLB2 http://www.ncbi.nlm.nih.gov/gene/?term=5342 PLGP1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015199 5345 SERPINF2 http://www.ncbi.nlm.nih.gov/gene/?term=5345 "A2AP, AAP, ALPHA-2-PI, API, PLI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015200 5346 PLIN1 http://www.ncbi.nlm.nih.gov/gene/?term=5346 "FPLD4, PERI, PLIN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015201 5347 PLK1 http://www.ncbi.nlm.nih.gov/gene/?term=5347 "PLK, STPK13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015202 5347 PLK1 http://www.ncbi.nlm.nih.gov/gene/?term=5347 "PLK, STPK13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015203 5348 FXYD1 http://www.ncbi.nlm.nih.gov/gene/?term=5348 PLM mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015204 5349 FXYD3 http://www.ncbi.nlm.nih.gov/gene/?term=5349 "MAT8, PLML " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015205 5349 FXYD3 http://www.ncbi.nlm.nih.gov/gene/?term=5349 "MAT8, PLML " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015206 5350 PLN http://www.ncbi.nlm.nih.gov/gene/?term=5350 "CMD1P, CMH18, PLB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015207 53510 Ugt86Da http://www.ncbi.nlm.nih.gov/gene/?term=53510 "Dmel_CG18578, AC 006491A, BEST:GM04645, CG18578, Dmel\CG18578, GM04645, ugt86Da " mRNA Drosophila melanogaster 25838129 Perinuclear Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00015208 53510 Ugt86Da http://www.ncbi.nlm.nih.gov/gene/?term=53510 "Dmel_CG18578, AC 006491A, BEST:GM04645, CG18578, Dmel\CG18578, GM04645, ugt86Da " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00015209 5351 PLOD1 http://www.ncbi.nlm.nih.gov/gene/?term=5351 "EDS6, LH, LH1, LLH, PLOD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015210 5351 PLOD1 http://www.ncbi.nlm.nih.gov/gene/?term=5351 "EDS6, LH, LH1, LLH, PLOD " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00015211 5351 PLOD1 http://www.ncbi.nlm.nih.gov/gene/?term=5351 "EDS6, LH, LH1, LLH, PLOD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015212 5352 PLOD2 http://www.ncbi.nlm.nih.gov/gene/?term=5352 "BRKS2, LH2, TLH " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00015213 5352 PLOD2 http://www.ncbi.nlm.nih.gov/gene/?term=5352 "BRKS2, LH2, TLH " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015214 5354 PLP1 http://www.ncbi.nlm.nih.gov/gene/?term=5354 "GPM6C, HLD1, MMPL, PLP, PLP/DM20, PMD, SPG2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015215 5355 PLP2 http://www.ncbi.nlm.nih.gov/gene/?term=5355 "A4, A4LSB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015216 5355 PLP2 http://www.ncbi.nlm.nih.gov/gene/?term=5355 "A4, A4LSB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015217 53563 gukh http://www.ncbi.nlm.nih.gov/gene/?term=53563 "Dmel_CG31043, CG14287, CG14288, CG31043, CG5456, CG6003, Dmel\CG31043, GUKH, GUKh, GukH, Gukh, anon-WO0118547.205 " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00015218 53563 gukh http://www.ncbi.nlm.nih.gov/gene/?term=53563 "Dmel_CG31043, CG14287, CG14288, CG31043, CG5456, CG6003, Dmel\CG31043, GUKH, GUKh, GukH, Gukh, anon-WO0118547.205 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00015219 5356 PLRG1 http://www.ncbi.nlm.nih.gov/gene/?term=5356 "Cwc1, PRL1, PRP46, PRPF46, TANGO4 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015220 5357 PLS1 http://www.ncbi.nlm.nih.gov/gene/?term=5357 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015221 5357 PLS1 http://www.ncbi.nlm.nih.gov/gene/?term=5357 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015222 5357 PLS1 http://www.ncbi.nlm.nih.gov/gene/?term=5357 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015223 53581 Gclc http://www.ncbi.nlm.nih.gov/gene/?term=53581 "Dmel_CG2259, 2259, CG2259, DmGCLC, DmGCS, DmGCSh, Dmel\CG2259, GCL, GCLC, GCLc, GCSh, Gcs, Gcsh, gclc " mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00015224 5358 PLS3 http://www.ncbi.nlm.nih.gov/gene/?term=5358 "BMND18, T-plastin " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015225 53599 Cd164 http://www.ncbi.nlm.nih.gov/gene/?term=53599 "A115, A24, AA589639, AW540279, MGC-24, MSSP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015226 5359 PLSCR1 http://www.ncbi.nlm.nih.gov/gene/?term=5359 MMTRA1B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015227 5359 PLSCR1 http://www.ncbi.nlm.nih.gov/gene/?term=5359 MMTRA1B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015228 535 ATP6V0A1 http://www.ncbi.nlm.nih.gov/gene/?term=535 "ATP6N1, ATP6N1A, Stv1, VPP1, Vph1, a1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015229 53600 Timm23 http://www.ncbi.nlm.nih.gov/gene/?term=53600 Tim23 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015230 53604 Zpbp http://www.ncbi.nlm.nih.gov/gene/?term=53604 "4930486K01Rik, Iam38, Sp38 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015231 53607 Snrpa http://www.ncbi.nlm.nih.gov/gene/?term=53607 "C430021M15Rik, Rnu1a-1, Rnu1a1, U1-A, U1A " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015232 53609 Clasrp http://www.ncbi.nlm.nih.gov/gene/?term=53609 "Clasp, Sfrs16, Srsf16, Swap2 " mRNA Mus musculus 25301173 Dendrite Hippocampus In situ hybridization "Figure 2: In situ hybridization reveals species-specific patterns of localization in neuronal dendrites. Fluorescent Microscopy evaluation of biotin-conjugated oligoprobes on paraformaldehyde fixed 14-day cultured rat and mouse cortical neurons hybridized with nine biotin-conjugated oligoprobes detected with streptadivin-Alexa Fluor 568 (Invitrogen). For each probe images set, the small bottom left corner panels represent MAP2 immuno-staining. Scale bar = 20um. (A), Probes against SFRS16, ARHGDIA and HNRPK transcripts show higher dendritic localization in mouse neurons than in rat neurons (Red box). (B), Probes against ZFP410, COMMD3 and RSP6 transcripts show higher dendritic localization in rat neurons than in mouse neurons (Blue box). (C), Probes against UBA52, OLFM1 and H2AFZ transcripts show high dendritic localization in both rat and mouse neurons (Black box). Data are collected from Figure 2. " RLID00015233 5360 PLTP http://www.ncbi.nlm.nih.gov/gene/?term=5360 "BPIFE, HDLCQ9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015234 53610 Nono http://www.ncbi.nlm.nih.gov/gene/?term=53610 "AA407051, AV149256, NRB54, P54NRB, nonA " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015235 53612 Vti1b http://www.ncbi.nlm.nih.gov/gene/?term=53612 "AU015348, GES30, MVti1b, SNARE, Vti1-rp1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015236 53614 Reck http://www.ncbi.nlm.nih.gov/gene/?term=53614 "St15, mRECK " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015237 53615 MBD3 http://www.ncbi.nlm.nih.gov/gene/?term=53615 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015238 53618 Fut8 http://www.ncbi.nlm.nih.gov/gene/?term=53618 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015239 53618 Fut8 http://www.ncbi.nlm.nih.gov/gene/?term=53618 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015240 5361 PLXNA1 http://www.ncbi.nlm.nih.gov/gene/?term=5361 "NOV, NOVP, PLEXIN-A1, PLXN1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015241 53620 Vamp5 http://www.ncbi.nlm.nih.gov/gene/?term=53620 "AF119384, Camp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015242 53620 Vamp5 http://www.ncbi.nlm.nih.gov/gene/?term=53620 "AF119384, Camp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015243 53621 Cnot4 http://www.ncbi.nlm.nih.gov/gene/?term=53621 "Not4, Not4h, Not4hp " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015244 53625 B3gnt2 http://www.ncbi.nlm.nih.gov/gene/?term=53625 "AA408337, AA409404, AW260308, B3Galt6, B3gnt1, BGnT-1, BGnT-2, BGnT1, BGnT2, Beta3gnt " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015245 5362 PLXNA2 http://www.ncbi.nlm.nih.gov/gene/?term=5362 "OCT, PLXN2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015246 53635 PTOV1 http://www.ncbi.nlm.nih.gov/gene/?term=53635 "ACID2, PTOV-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015247 53635 PTOV1 http://www.ncbi.nlm.nih.gov/gene/?term=53635 "ACID2, PTOV-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015248 53635 PTOV1 http://www.ncbi.nlm.nih.gov/gene/?term=53635 "ACID2, PTOV-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015249 5364 PLXNB1 http://www.ncbi.nlm.nih.gov/gene/?term=5364 "PLEXIN-B1, PLXN5, SEP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015250 5364 PLXNB1 http://www.ncbi.nlm.nih.gov/gene/?term=5364 "PLEXIN-B1, PLXN5, SEP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015251 5365 PLXNB3 http://www.ncbi.nlm.nih.gov/gene/?term=5365 "PLEXB3, PLEXR, PLXN6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015252 5366 PMAIP1 http://www.ncbi.nlm.nih.gov/gene/?term=5366 "APR, NOXA " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015253 5366 PMAIP1 http://www.ncbi.nlm.nih.gov/gene/?term=5366 "APR, NOXA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015254 5366 PMAIP1 http://www.ncbi.nlm.nih.gov/gene/?term=5366 "APR, NOXA " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015255 5366 PMAIP1 http://www.ncbi.nlm.nih.gov/gene/?term=5366 "APR, NOXA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015256 5371 PML http://www.ncbi.nlm.nih.gov/gene/?term=5371 "MYL, PP8675, RNF71, TRIM19 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015257 5372 PMM1 http://www.ncbi.nlm.nih.gov/gene/?term=5372 Sec53 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015258 5372 PMM1 http://www.ncbi.nlm.nih.gov/gene/?term=5372 Sec53 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015259 5373 PMM2 http://www.ncbi.nlm.nih.gov/gene/?term=5373 "CDG1, CDG1a, CDGS, PMI, PMI1, PMM 2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015260 5373 PMM2 http://www.ncbi.nlm.nih.gov/gene/?term=5373 "CDG1, CDG1a, CDGS, PMI, PMI1, PMM 2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015261 5373 PMM2 http://www.ncbi.nlm.nih.gov/gene/?term=5373 "CDG1, CDG1a, CDGS, PMI, PMI1, PMM 2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015262 5376 PMP22 http://www.ncbi.nlm.nih.gov/gene/?term=5376 "CMT1A, CMT1E, DSS, GAS-3, GAS3, HMSNIA, HNPP, Sp110 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00015263 5376 PMP22 http://www.ncbi.nlm.nih.gov/gene/?term=5376 "CMT1A, CMT1E, DSS, GAS-3, GAS3, HMSNIA, HNPP, Sp110 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015264 5376 PMP22 http://www.ncbi.nlm.nih.gov/gene/?term=5376 "DSS, GAS3, HNPP, CMT1A, CMT1E, GAS-3, Sp110, HMSNIA " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00015265 5379 PMS2P1 http://www.ncbi.nlm.nih.gov/gene/?term=5379 "PMS2L1, PMS2L13, PMS2L6, PMS2L7, PMS2L8, PMS3, PMS8, PMSR1, PMSR2 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015266 537 ATP6AP1 http://www.ncbi.nlm.nih.gov/gene/?term=537 "16A, ATP6IP1, ATP6S1, Ac45, CF2, VATPS1, XAP-3, XAP3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015267 537 ATP6AP1 http://www.ncbi.nlm.nih.gov/gene/?term=537 "16A, ATP6IP1, ATP6S1, Ac45, CF2, VATPS1, XAP-3, XAP3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015268 53820 RIPPLY3 http://www.ncbi.nlm.nih.gov/gene/?term=53820 DSCR6 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015269 53820 RIPPLY3 http://www.ncbi.nlm.nih.gov/gene/?term=53820 DSCR6 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015270 53827 FXYD5 http://www.ncbi.nlm.nih.gov/gene/?term=53827 "DYSAD, HSPC113, IWU1, KCT1, OIT2, PRO6241, RIC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015271 5382 PMS2P4 http://www.ncbi.nlm.nih.gov/gene/?term=5382 "PMS2L4, PMS6 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015272 53834 FGFRL1 http://www.ncbi.nlm.nih.gov/gene/?term=53834 "FGFR5, FHFR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015273 53834 FGFRL1 http://www.ncbi.nlm.nih.gov/gene/?term=53834 "FGFR5, FHFR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015274 53838 C11orf24 http://www.ncbi.nlm.nih.gov/gene/?term=53838 DM4E3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015275 53840 TRIM34 http://www.ncbi.nlm.nih.gov/gene/?term=53840 "IFP1, RNF21 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015276 53840 TRIM34 http://www.ncbi.nlm.nih.gov/gene/?term=53840 "IFP1, RNF21 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015277 53857 Tuba8 http://www.ncbi.nlm.nih.gov/gene/?term=53857 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015278 53861 Zranb2 http://www.ncbi.nlm.nih.gov/gene/?term=53861 "AI227013, Zfp265, Zis, Znf265 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015279 53872 Caprin1 http://www.ncbi.nlm.nih.gov/gene/?term=53872 "AL022980, Caprin-1, Gpiap, Gpiap1, Mmgpip137, P137, rng105 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015280 53872 Caprin1 http://www.ncbi.nlm.nih.gov/gene/?term=53872 "AL022980, Caprin-1, Gpiap, Gpiap1, Mmgpip137, P137, rng105 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015281 538 ATP7A http://www.ncbi.nlm.nih.gov/gene/?term=538 "DSMAX, MK, MNK, SMAX3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015282 538 ATP7A http://www.ncbi.nlm.nih.gov/gene/?term=538 "DSMAX, MK, MNK, SMAX3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015283 538 ATP7A http://www.ncbi.nlm.nih.gov/gene/?term=538 "DSMAX, MK, MNK, SMAX3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015284 538 ATP7A http://www.ncbi.nlm.nih.gov/gene/?term=538 "DSMAX, MK, MNK, SMAX3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015285 53902 Rcan3 http://www.ncbi.nlm.nih.gov/gene/?term=53902 "AU041093, Csp3, Dscr1l2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015286 53916 RAB4B http://www.ncbi.nlm.nih.gov/gene/?term=53916 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015287 53917 RAB24 http://www.ncbi.nlm.nih.gov/gene/?term=53917 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015288 53918 PELO http://www.ncbi.nlm.nih.gov/gene/?term=53918 "CGI-17, PRO1770 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015289 53918 PELO http://www.ncbi.nlm.nih.gov/gene/?term=53918 "CGI-17, PRO1770 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015290 53918 PELO http://www.ncbi.nlm.nih.gov/gene/?term=53918 "CGI-17, PRO1770 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015291 53938 PPIL3 http://www.ncbi.nlm.nih.gov/gene/?term=53938 CYPJ mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015292 53938 PPIL3 http://www.ncbi.nlm.nih.gov/gene/?term=53938 CYPJ mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015293 5393 EXOSC9 http://www.ncbi.nlm.nih.gov/gene/?term=5393 "PM/Scl-75, PMSCL1, RRP45, Rrp45p, p5, p6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015294 53942 CNTN5 http://www.ncbi.nlm.nih.gov/gene/?term=53942 "HNB-2s, NB-2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015295 5394 EXOSC10 http://www.ncbi.nlm.nih.gov/gene/?term=5394 "PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015296 5394 EXOSC10 http://www.ncbi.nlm.nih.gov/gene/?term=5394 "PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015297 5394 EXOSC10 http://www.ncbi.nlm.nih.gov/gene/?term=5394 "PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015298 53951 Gpatch11 http://www.ncbi.nlm.nih.gov/gene/?term=53951 "2310002B06Rik, C80922, Ccdc75, L26697 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015299 5395 PMS2 http://www.ncbi.nlm.nih.gov/gene/?term=5395 "HNPCC4, MLH4CL, PMSL2, PMS2 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00015300 5395 PMS2 http://www.ncbi.nlm.nih.gov/gene/?term=5395 "MLH4, PMSL2, HNPCC4, PMS2CL " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00015301 53960 AA066038 http://www.ncbi.nlm.nih.gov/gene/?term=53960 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015302 53975 Ddx20 http://www.ncbi.nlm.nih.gov/gene/?term=53975 "GEMIN3, dp103 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015303 53981 CPSF2 http://www.ncbi.nlm.nih.gov/gene/?term=53981 CPSF100 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015304 53981 CPSF2 http://www.ncbi.nlm.nih.gov/gene/?term=53981 CPSF100 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015305 53981 CPSF2 http://www.ncbi.nlm.nih.gov/gene/?term=53981 CPSF100 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015306 53981 CPSF2 http://www.ncbi.nlm.nih.gov/gene/?term=53981 CPSF100 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015307 53981 CPSF2 http://www.ncbi.nlm.nih.gov/gene/?term=53981 CPSF100 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015308 539 ATP5O http://www.ncbi.nlm.nih.gov/gene/?term=539 "ATPO, HMC08D05, OSCP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015309 539 ATP5O http://www.ncbi.nlm.nih.gov/gene/?term=539 "ATPO, HMC08D05, OSCP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015310 53 ACP2 http://www.ncbi.nlm.nih.gov/gene/?term=53 LAP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015311 53 ACP2 http://www.ncbi.nlm.nih.gov/gene/?term=53 LAP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015312 54004 Diaph2 http://www.ncbi.nlm.nih.gov/gene/?term=54004 "Dia3, Diap2, Drf2, E430022I22Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015313 54014 BRWD1 http://www.ncbi.nlm.nih.gov/gene/?term=54014 "C21orf107, DCAF19, N143, WDR9 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015314 54014 BRWD1 http://www.ncbi.nlm.nih.gov/gene/?term=54014 "C21orf107, DCAF19, N143, WDR9 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015315 54014 BRWD1 http://www.ncbi.nlm.nih.gov/gene/?term=54014 "C21orf107, DCAF19, N143, WDR9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015316 54065 SMIM11A http://www.ncbi.nlm.nih.gov/gene/?term=54065 "C21orf51, FAM165B, SMIM11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015317 54065 SMIM11A http://www.ncbi.nlm.nih.gov/gene/?term=54065 "C21orf51, FAM165B, SMIM11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015318 54067 C21orf62-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=54067 C21orf49 lncRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00015319 54069 MIS18A http://www.ncbi.nlm.nih.gov/gene/?term=54069 "B28, C21orf45, C21orf46, FASP1, MIS18alpha, hMis18alpha " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015320 54069 MIS18A http://www.ncbi.nlm.nih.gov/gene/?term=54069 "B28, C21orf45, C21orf46, FASP1, MIS18alpha, hMis18alpha " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015321 54093 SETD4 http://www.ncbi.nlm.nih.gov/gene/?term=54093 "C21orf18, C21orf27 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015322 54097 FAM3B http://www.ncbi.nlm.nih.gov/gene/?term=54097 "2-21, C21orf11, C21orf76, ORF9, PANDER, PRED44 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015323 5409 PNMT http://www.ncbi.nlm.nih.gov/gene/?term=5409 "PENT, PNMTase " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015324 540 ATP7B http://www.ncbi.nlm.nih.gov/gene/?term=540 "PWD, WC1, WD, WND " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015325 54107 POLE3 http://www.ncbi.nlm.nih.gov/gene/?term=54107 "CHARAC17, CHRAC17, YBL1, p17 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015326 54107 POLE3 http://www.ncbi.nlm.nih.gov/gene/?term=54107 "CHARAC17, CHRAC17, YBL1, p17 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015327 54107 POLE3 http://www.ncbi.nlm.nih.gov/gene/?term=54107 "CHARAC17, CHRAC17, YBL1, p17 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015328 54107 POLE3 http://www.ncbi.nlm.nih.gov/gene/?term=54107 "CHARAC17, CHRAC17, YBL1, p17 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015329 54108 CHRAC1 http://www.ncbi.nlm.nih.gov/gene/?term=54108 "CHARC1, CHARC15, CHRAC-1, CHRAC-155, YCL1, CHRAC1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015330 5411 PNN http://www.ncbi.nlm.nih.gov/gene/?term=5411 "DRS, DRSP, SDK3, memA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015331 5411 PNN http://www.ncbi.nlm.nih.gov/gene/?term=5411 "DRS, DRSP, SDK3, memA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015332 5411 PNN http://www.ncbi.nlm.nih.gov/gene/?term=5411 "DRS, DRSP, SDK3, memA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015333 54127 Rps28 http://www.ncbi.nlm.nih.gov/gene/?term=54127 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015334 5412 UBL3 http://www.ncbi.nlm.nih.gov/gene/?term=5412 "HCG-1, PNSC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015335 54130 Actr1a http://www.ncbi.nlm.nih.gov/gene/?term=54130 "Arp1, alpha-Arp1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015336 54131 Irf3 http://www.ncbi.nlm.nih.gov/gene/?term=54131 "C920001K05Rik, IRF-3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015337 54137 Acrbp http://www.ncbi.nlm.nih.gov/gene/?term=54137 "OY-TES-1, sp32 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015338 54141 Spag5 http://www.ncbi.nlm.nih.gov/gene/?term=54141 "AI874642, D11Bhm180e, Deepest, MAP126, Mastrin, S17 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015339 541463 Tex24 http://www.ncbi.nlm.nih.gov/gene/?term=541463 "1700108N07Rik, TESF-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015340 541471 MIR4435-2HG http://www.ncbi.nlm.nih.gov/gene/?term=541471 "AGD2, AK001796, LINC00978, MIR4435-1HG " lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015341 541471 MIR4435-2HG http://www.ncbi.nlm.nih.gov/gene/?term=541471 "AGD2, AK001796, LINC00978, MIR4435-1HG " lncRNA Homo sapiens 25630241 Cytoplasm Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00015342 541471 MIR4435-2HG http://www.ncbi.nlm.nih.gov/gene/?term=541471 "AGD2, AK001796, LINC00978, MIR4435-1HG " lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00015343 541471 MIR4435-2HG http://www.ncbi.nlm.nih.gov/gene/?term=541471 "AGD2, AK001796, LINC00978, MIR4435-1HG " lncRNA Homo sapiens 25630241 Nucleus Hela cell qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00015344 54148 MRPL39 http://www.ncbi.nlm.nih.gov/gene/?term=54148 "C21orf92, L39mt, MRP-L5, MRPL5, MSTP003, PRED22, PRED66, RPML5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015345 54150 Rdh7 http://www.ncbi.nlm.nih.gov/gene/?term=54150 "AI194929, CRAD2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015346 54152 Dnal4 http://www.ncbi.nlm.nih.gov/gene/?term=54152 "D15Ertd424e, Dnalc4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015347 541578 CXorf40B http://www.ncbi.nlm.nih.gov/gene/?term=541578 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015348 541578 CXorf40B http://www.ncbi.nlm.nih.gov/gene/?term=541578 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015349 54161 Copg1 http://www.ncbi.nlm.nih.gov/gene/?term=54161 "AU019265, BC056168, Copg, D6Ertd71e, D6Wsu16e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015350 541640 leg1 http://www.ncbi.nlm.nih.gov/gene/?term=541640 "ZEAMMB73_079584, GRMZM2G174883, cb " mRNA Zea mays 15653801 Endoplasmic reticulum Endosperm RT-PCR "Indeed, in situ RT-PCR and confocal microscopy analysis showed that legumin-1 RNAs are distributed in a pattern markedly distinct from that observed for the zein RNAs. Instead of the punctate pattern indicative of the localization of zein RNAs to the zein PBs, legumin-1 RNAs were distributed as large fluorescent patches. The size and shape of these fluorescent patches and their close proximity to the zein PBs is consistent with the location of legumin-1 RNAs on lamellar membranes of the cis-ER (Fig. 4). " RLID00015351 54165 DCUN1D1 http://www.ncbi.nlm.nih.gov/gene/?term=54165 "DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015352 54165 DCUN1D1 http://www.ncbi.nlm.nih.gov/gene/?term=54165 "DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015353 54187 NANS http://www.ncbi.nlm.nih.gov/gene/?term=54187 "HEL-S-100, SAS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015354 54187 NANS http://www.ncbi.nlm.nih.gov/gene/?term=54187 "HEL-S-100, SAS " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015355 54188 Cpsf4 http://www.ncbi.nlm.nih.gov/gene/?term=54188 "30kDa, C79664 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015356 54189 Rabep1 http://www.ncbi.nlm.nih.gov/gene/?term=54189 "Rab5ep, rabaptin-5, rabaptin-5alpha " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015357 541922 dzs10 http://www.ncbi.nlm.nih.gov/gene/?term=541922 mRNA Zea mays 15653801 Endoplasmic reticulum Endosperm RT-PCR "RNAs coding for 22 kDa alpha-zein, 15 kDa beta-zein, 27 kDa gamma-zein and 10 kDa delta-zein were localized to ER-bounded zein protein bodies, whereas 51 kDa legumin-1 RNAs were distributed on adjacent cisternal ER proximal to the zein protein bodies. " RLID00015358 541926 az22z5 http://www.ncbi.nlm.nih.gov/gene/?term=541926 "ZEAMMB73_710866, GRMZM2G088365 " mRNA Zea mays 15653801 Endoplasmic reticulum Endosperm RT-PCR "RNAs coding for 22 kDa alpha-zein, 15 kDa beta-zein, 27 kDa gamma-zein and 10 kDa delta-zein were localized to ER-bounded zein protein bodies, whereas 51 kDa legumin-1 RNAs were distributed on adjacent cisternal ER proximal to the zein protein bodies " RLID00015359 54195 Gucy1b3 http://www.ncbi.nlm.nih.gov/gene/?term=54195 "GC-S-beta-1, GCbeta1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015360 54196 Pabpn1 http://www.ncbi.nlm.nih.gov/gene/?term=54196 "PAB2, Pabp3, mPABII " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015361 54205 CYCS http://www.ncbi.nlm.nih.gov/gene/?term=54205 "CYC, HCS, THC4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015362 54205 CYCS http://www.ncbi.nlm.nih.gov/gene/?term=54205 "CYC, HCS, THC4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015363 54205 CYCS http://www.ncbi.nlm.nih.gov/gene/?term=54205 "CYC, HCS, THC4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015364 54205 CYCS http://www.ncbi.nlm.nih.gov/gene/?term=54205 "CYC, HCS, THC4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015365 54206 ERRFI1 http://www.ncbi.nlm.nih.gov/gene/?term=54206 "GENE-33, MIG-6, MIG6, RALT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015366 54206 ERRFI1 http://www.ncbi.nlm.nih.gov/gene/?term=54206 "GENE-33, MIG-6, MIG6, RALT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015367 54208 Arl6ip1 http://www.ncbi.nlm.nih.gov/gene/?term=54208 "AIP-6, AL022945, ARMER, AU042858, Aip-1, Arl6ip, C85138, mKIAA0069 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015368 5420 PODXL http://www.ncbi.nlm.nih.gov/gene/?term=5420 "Gp200, PC, PCLP, PCLP-1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015369 54217 Rpl36 http://www.ncbi.nlm.nih.gov/gene/?term=54217 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015370 54217 Rpl36 http://www.ncbi.nlm.nih.gov/gene/?term=54217 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00015371 542296 LOC542296 http://www.ncbi.nlm.nih.gov/gene/?term=542296 "ZEAMMB73_835432, GRMZM2G138727 " mRNA Zea mays 15653801 Endoplasmic reticulum Endosperm RT-PCR "RNAs coding for 22 kDa alpha-zein, 15 kDa beta-zein, 27 kDa gamma-zein and 10 kDa delta-zein were localized to ER-bounded zein protein bodies, whereas 51 kDa legumin-1 RNAs were distributed on adjacent cisternal ER proximal to the zein protein bodies. " RLID00015372 5423 POLB http://www.ncbi.nlm.nih.gov/gene/?term=5423 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015373 5423 POLB http://www.ncbi.nlm.nih.gov/gene/?term=5423 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015374 5423 POLB http://www.ncbi.nlm.nih.gov/gene/?term=5423 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015375 5424 POLD1 http://www.ncbi.nlm.nih.gov/gene/?term=5424 "CDC2, CRCS10, MDPL, POLD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015376 5424 POLD1 http://www.ncbi.nlm.nih.gov/gene/?term=5424 "CDC2, CRCS10, MDPL, POLD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015377 5425 POLD2 http://www.ncbi.nlm.nih.gov/gene/?term=5425 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015378 5425 POLD2 http://www.ncbi.nlm.nih.gov/gene/?term=5425 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015379 5426 POLE http://www.ncbi.nlm.nih.gov/gene/?term=5426 "CRCS12, FILS1, POLE " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015380 5426 POLE http://www.ncbi.nlm.nih.gov/gene/?term=5426 "CRCS12, FILS, POLE1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015381 542732 crt2 http://www.ncbi.nlm.nih.gov/gene/?term=542732 "ZEAMMB73_853300, CRH, GRMZM2G358059 " mRNA Zea mays 17882422 Endoplasmic reticulum Callus In situ hybridization "Calreticulin mRNAs were selectively targeted to the endoplasmic reticulum (ER) subdomains surrounding protein bodies. These data suggest that calreticulin mRNA is targeted towards protein body forming subdomains of the ER, and that calreticulin is localized and enriched in these protein bodies. High levels of calreticulin mRNAs were observed in these callus cells (Fig. 2a). D " RLID00015382 542760 zp15 http://www.ncbi.nlm.nih.gov/gene/?term=542760 "ZEAMMB73_427631, bz15, zein-2 " mRNA Zea mays 15653801 Endoplasmic reticulum Endosperm RT-PCR "RNAs coding for 22 kDa alpha-zein, 15 kDa beta-zein, 27 kDa gamma-zein and 10 kDa delta-zein were localized to ER-bounded zein protein bodies, whereas 51 kDa legumin-1 RNAs were distributed on adjacent cisternal ER proximal to the zein protein bodies. " RLID00015383 5428 POLG http://www.ncbi.nlm.nih.gov/gene/?term=5428 "MDP1, MIRAS, MTDPS4A, MTDPS4B, PEO1, POLGA, SANDO, SCAE, POLG " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015384 5429 POLH http://www.ncbi.nlm.nih.gov/gene/?term=5429 "RAD30, RAD30A, XP-V, XPV " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015385 5429 POLH http://www.ncbi.nlm.nih.gov/gene/?term=5429 "RAD30, RAD30A, XP-V, XPV " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015386 5430 POLR2A http://www.ncbi.nlm.nih.gov/gene/?term=5430 "POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015387 5430 POLR2A http://www.ncbi.nlm.nih.gov/gene/?term=5430 "POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015388 54315 Ucp2 http://www.ncbi.nlm.nih.gov/gene/?term=54315 mRNA Rattus norvegicus 15485813 Nucleus Hepatoma cell qRT-PCR The three-hybrid screen and the co-IP results show that the K protein interaction with ucp2 mRNA is specific. These results (Fig. 2) also show that K protein-ucp2 mRNA complexes are found in multiple subcellular compartments. Data are collected from Figure 2. RLID00015389 54315 Ucp2 http://www.ncbi.nlm.nih.gov/gene/?term=54315 mRNA Rattus norvegicus 15485813 Cytoplasm Hepatoma cell qRT-PCR The three-hybrid screen and the co-IP results show that the K protein interaction with ucp2 mRNA is specific. These results (Fig. 2) also show that K protein-ucp2 mRNA complexes are found in multiple subcellular compartments. Data are collected from Figure 2. RLID00015390 54315 Ucp2 http://www.ncbi.nlm.nih.gov/gene/?term=54315 mRNA Rattus norvegicus 15485813 Mitochondrion Hepatoma cell qRT-PCR The three-hybrid screen and the co-IP results show that the K protein interaction with ucp2 mRNA is specific. These results (Fig. 2) also show that K protein-ucp2 mRNA complexes are found in multiple subcellular compartments. Data are collected from Figure 2. RLID00015391 5431 POLR2B http://www.ncbi.nlm.nih.gov/gene/?term=5431 "POL2RB, RPB2, hRPB140 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015392 5431 POLR2B http://www.ncbi.nlm.nih.gov/gene/?term=5431 "POL2RB, RPB2, hRPB140 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015393 54323 Arc http://www.ncbi.nlm.nih.gov/gene/?term=54323 rg3.1 mRNA Rattus norvegicus 7857651 Dendrite Hippocampus In situ hybridization "In situ studies provided evidence of an unusual cellular localization of Arc mRNA. Figure 5. Arc mRNA Is Expressed in the Molecular Layer of the Hippocampus, Suggesting Dendritic Localization. " RLID00015394 54323 Arc http://www.ncbi.nlm.nih.gov/gene/?term=54323 rg3.1 mRNA Rattus norvegicus 17765733 Dendrite Hippocampus - Arc mRNA is strongly induced and transported to dendritic processes following high-frequency stimulation (HFS) that induces LTP in the rat dentate gyrus in vivo. RLID00015395 54323 Arc http://www.ncbi.nlm.nih.gov/gene/?term=54323 rg3.1 mRNA Rattus norvegicus 22350812 Dendrite Cortical neuron GFP-labeling|Live imaging "In the course of our studies of Arc mRNA transport in dendrites, we noticed that apparently stationary Arc/MS2 mRNA particles were often precisely localized beneath the base of dendritic spines. In these images, many stationary Arc/MS2 mRNA particles were localized at or near the base of dendritic spines and many spines had underlying Arc/MS2 particles (Fig. 1D,G-K). " RLID00015396 54323 Arc http://www.ncbi.nlm.nih.gov/gene/?term=54323 rg3.1 mRNA Rattus norvegicus 24671994 Synapse - Fluorescence in situ hybridization Here we show in vivo in rats that newly synthesized Arc mRNA accumulates at activated synapses and that synaptic activity simultaneously triggers mRNA decay that eliminates Arc mRNA from inactive dendritic domains. RLID00015397 54323 Arc http://www.ncbi.nlm.nih.gov/gene/?term=54323 rg3.1 mRNA Rattus norvegicus 25628532 Dendrite Brain In situ hybridizationqRT-PCR "Subsequent studies revealed that Arc/MS2 mRNA localized with remarkable precision at the base of dendritic spines (Figures 1G,H). " RLID00015398 54323 Arc http://www.ncbi.nlm.nih.gov/gene/?term=54323 rg3.1 mRNA Rattus norvegicus 7773006 Dendrite Neuron In situ hybridization "Table 1. As of 1994, mRNAs that have been localized within dendrites by in situ hybridization. Data are collected from Table 1. " RLID00015399 54326 Elovl2 http://www.ncbi.nlm.nih.gov/gene/?term=54326 "AI317360, Ssc2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015400 5432 POLR2C http://www.ncbi.nlm.nih.gov/gene/?term=5432 "RPB3, RPB31, hRPB33, hsRPB3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015401 5432 POLR2C http://www.ncbi.nlm.nih.gov/gene/?term=5432 "RPB3, RPB31, hRPB33, hsRPB3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015402 5432 POLR2C http://www.ncbi.nlm.nih.gov/gene/?term=5432 "RPB3, RPB31, hRPB33, hsRPB3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015403 54331 GNG2 http://www.ncbi.nlm.nih.gov/gene/?term=54331 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015404 5433 POLR2D http://www.ncbi.nlm.nih.gov/gene/?term=5433 "HSRBP4, HSRPB4, RBP4, RPB16 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015405 54343 Atf7ip http://www.ncbi.nlm.nih.gov/gene/?term=54343 "2610204M12Rik, AM, Mcaf1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015406 54344 DPM3 http://www.ncbi.nlm.nih.gov/gene/?term=54344 CDG1O mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015407 5434 POLR2E http://www.ncbi.nlm.nih.gov/gene/?term=5434 "RPABC1, RPB5, XAP4, hRPB25, hsRPB5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015408 5434 POLR2E http://www.ncbi.nlm.nih.gov/gene/?term=5434 "RPABC1, RPB5, XAP4, hRPB25, hsRPB5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015409 54352 Irx5 http://www.ncbi.nlm.nih.gov/gene/?term=54352 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015410 5435 POLR2F http://www.ncbi.nlm.nih.gov/gene/?term=5435 "HRBP14.4, POLRF, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015411 5435 POLR2F http://www.ncbi.nlm.nih.gov/gene/?term=5435 "HRBP14.4, POLRF, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015412 54363 HAO1 http://www.ncbi.nlm.nih.gov/gene/?term=54363 "GOX, GOX1, HAOX1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015413 54364 Rpp30 http://www.ncbi.nlm.nih.gov/gene/?term=54364 "Rnasep2, TSG15 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015414 54367 Zfp326 http://www.ncbi.nlm.nih.gov/gene/?term=54367 "5730470H14Rik, ZAN75, Znf326 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015415 54369 Nme6 http://www.ncbi.nlm.nih.gov/gene/?term=54369 nm23-M6 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015416 5436 POLR2G http://www.ncbi.nlm.nih.gov/gene/?term=5436 "RPB19, RPB7, hRPB19, hsRPB7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015417 5436 POLR2G http://www.ncbi.nlm.nih.gov/gene/?term=5436 "RPB19, RPB7, hRPB19, hsRPB7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015418 54375 Azin1 http://www.ncbi.nlm.nih.gov/gene/?term=54375 "1700085L02Rik, AZI, Oazi, Oazin " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015419 5437 POLR2H http://www.ncbi.nlm.nih.gov/gene/?term=5437 "RPABC3, RPB17, RPB8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015420 54383 Phc2 http://www.ncbi.nlm.nih.gov/gene/?term=54383 "A3galt2, AA415044, D130050K19Rik, D4Ertd810e, Edr2, Mph2, p36 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015421 54386 TERF2IP http://www.ncbi.nlm.nih.gov/gene/?term=54386 "DRIP5, RAP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015422 54386 TERF2IP http://www.ncbi.nlm.nih.gov/gene/?term=54386 "DRIP5, RAP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015423 54386 TERF2IP http://www.ncbi.nlm.nih.gov/gene/?term=54386 "DRIP5, RAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015424 5438 POLR2I http://www.ncbi.nlm.nih.gov/gene/?term=5438 "RPB9, hRPB14.5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015425 5438 POLR2I http://www.ncbi.nlm.nih.gov/gene/?term=5438 "RPB9, hRPB14.5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015426 5439 POLR2J http://www.ncbi.nlm.nih.gov/gene/?term=5439 "POLR2J1, RPB11, RPB11A, RPB11m, hRPB14 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015427 5439 POLR2J http://www.ncbi.nlm.nih.gov/gene/?term=5439 "POLR2J1, RPB11, RPB11A, RPB11m, hRPB14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015428 54401 Ywhab http://www.ncbi.nlm.nih.gov/gene/?term=54401 1300003C17Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015429 54407 SLC38A2 http://www.ncbi.nlm.nih.gov/gene/?term=54407 "ATA2, PRO1068, SAT2, SNAT2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015430 54407 SLC38A2 http://www.ncbi.nlm.nih.gov/gene/?term=54407 "ATA2, PRO1068, SAT2, SNAT2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015431 54407 SLC38A2 http://www.ncbi.nlm.nih.gov/gene/?term=54407 "ATA2, PRO1068, SAT2, SNAT2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015432 54407 SLC38A2 http://www.ncbi.nlm.nih.gov/gene/?term=54407 "ATA2, PRO1068, SAT2, SNAT2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015433 5440 POLR2K http://www.ncbi.nlm.nih.gov/gene/?term=5440 "ABC10-alpha, RPABC4, RPB10alpha, RPB12, RPB7.0, hRPB7.0, hsRPB10a " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015434 5440 POLR2K http://www.ncbi.nlm.nih.gov/gene/?term=5440 "ABC10-alpha, RPABC4, RPB10alpha, RPB12, RPB7.0, hRPB7.0, hsRPB10a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015435 54414 SIAE http://www.ncbi.nlm.nih.gov/gene/?term=54414 "AIS6, CSE-C, CSEC, LSE, YSG2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015436 5441 POLR2L http://www.ncbi.nlm.nih.gov/gene/?term=5441 "RBP10, RPABC5, RPB10, RPB10beta, RPB7.6, hRPB7.6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015437 5441 POLR2L http://www.ncbi.nlm.nih.gov/gene/?term=5441 "RBP10, RPABC5, RPB10, RPB10beta, RPB7.6, hRPB7.6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015438 5442 POLRMT http://www.ncbi.nlm.nih.gov/gene/?term=5442 "APOLMT, MTRNAP, MTRPOL, h-mtRPOL " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015439 5442 POLRMT http://www.ncbi.nlm.nih.gov/gene/?term=5442 "APOLMT, MTRNAP, MTRPOL, h-mtRPOL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015440 54431 DNAJC10 http://www.ncbi.nlm.nih.gov/gene/?term=54431 "ERdj5, JPDI, MTHr, PDIA19 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015441 54431 DNAJC10 http://www.ncbi.nlm.nih.gov/gene/?term=54431 "ERdj5, JPDI, MTHr, PDIA19 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015442 54434 SSH1 http://www.ncbi.nlm.nih.gov/gene/?term=54434 SSH1L mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015443 54434 SSH1 http://www.ncbi.nlm.nih.gov/gene/?term=54434 SSH1L mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015444 54439 RBM27 http://www.ncbi.nlm.nih.gov/gene/?term=54439 "ARRS1, Psc1, ZC3H18, ZC3H20 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015445 54439 RBM27 http://www.ncbi.nlm.nih.gov/gene/?term=54439 "ARRS1, Psc1, ZC3H18, ZC3H20 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015446 54439 RBM27 http://www.ncbi.nlm.nih.gov/gene/?term=54439 "ARRS1, Psc1, ZC3H18, ZC3H20 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015447 5443 POMC http://www.ncbi.nlm.nih.gov/gene/?term=5443 "ACTH, CLIP, LPH, MSH, NPP, POC " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015448 54441 STAG3L1 http://www.ncbi.nlm.nih.gov/gene/?term=54441 "STAG3L1P, STAG3L2, STAG3L3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015449 54441 STAG3L1 http://www.ncbi.nlm.nih.gov/gene/?term=54441 "STAG3L1P, STAG3L2, STAG3L3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015450 54442 KCTD5 http://www.ncbi.nlm.nih.gov/gene/?term=54442 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015451 54442 KCTD5 http://www.ncbi.nlm.nih.gov/gene/?term=54442 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015452 54442 KCTD5 http://www.ncbi.nlm.nih.gov/gene/?term=54442 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015453 54443 ANLN http://www.ncbi.nlm.nih.gov/gene/?term=54443 "FSGS8, Scraps, scra " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015454 54446 Nfat5 http://www.ncbi.nlm.nih.gov/gene/?term=54446 "AI225870, B130038B15Rik, CAG-8, CAG80, NFATL1, OREBP, TonEBP, mKIAA0827, nfatz " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015455 54447 Asah2 http://www.ncbi.nlm.nih.gov/gene/?term=54447 AI585898 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015456 5444 PON1 http://www.ncbi.nlm.nih.gov/gene/?term=5444 "ESA, MVCD5, PON " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015457 5444 PON1 http://www.ncbi.nlm.nih.gov/gene/?term=5444 "ESA, MVCD5, PON " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015458 54451 Cpsf3 http://www.ncbi.nlm.nih.gov/gene/?term=54451 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015459 54454 ATAD2B http://www.ncbi.nlm.nih.gov/gene/?term=54454 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015460 54455 FBXO42 http://www.ncbi.nlm.nih.gov/gene/?term=54455 "Fbx42, JFK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015461 54455 FBXO42 http://www.ncbi.nlm.nih.gov/gene/?term=54455 "Fbx42, JFK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015462 54457 TAF7L http://www.ncbi.nlm.nih.gov/gene/?term=54457 "CT40, TAF2Q " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015463 54458 PRR13 http://www.ncbi.nlm.nih.gov/gene/?term=54458 TXR1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015464 5445 PON2 http://www.ncbi.nlm.nih.gov/gene/?term=5445 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015465 5445 PON2 http://www.ncbi.nlm.nih.gov/gene/?term=5445 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015466 54460 MRPS21 http://www.ncbi.nlm.nih.gov/gene/?term=54460 "MDS016, MRP-S21, RPMS21 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015467 54461 FBXW5 http://www.ncbi.nlm.nih.gov/gene/?term=54461 Fbw5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015468 54462 CCSER2 http://www.ncbi.nlm.nih.gov/gene/?term=54462 "FAM190B, Gcap14, KIAA1128, bA486O22.1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015469 54462 CCSER2 http://www.ncbi.nlm.nih.gov/gene/?term=54462 "FAM190B, Gcap14, KIAA1128, bA486O22.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015470 54462 CCSER2 http://www.ncbi.nlm.nih.gov/gene/?term=54462 "FAM190B, Gcap14, KIAA1128, bA486O22.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015471 54463 FAM134B http://www.ncbi.nlm.nih.gov/gene/?term=54463 "JK-1, JK1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015472 54464 XRN1 http://www.ncbi.nlm.nih.gov/gene/?term=54464 42614 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015473 54464 XRN1 http://www.ncbi.nlm.nih.gov/gene/?term=54464 42614 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015474 54467 ANKIB1 http://www.ncbi.nlm.nih.gov/gene/?term=54467 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015475 54468 MIOS http://www.ncbi.nlm.nih.gov/gene/?term=54468 MIO mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015476 544696 Tbc1d32 http://www.ncbi.nlm.nih.gov/gene/?term=544696 "Bromi, D630037F22Rik, b2b2284Clo " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015477 544696 Tbc1d32 http://www.ncbi.nlm.nih.gov/gene/?term=544696 "Bromi, D630037F22Rik, b2b2284Clo " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015478 54469 ZFAND6 http://www.ncbi.nlm.nih.gov/gene/?term=54469 "AWP1, ZA20D3, ZFAND5B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015479 54470 ARMCX6 http://www.ncbi.nlm.nih.gov/gene/?term=54470 GASP10 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015480 54472 TOLLIP http://www.ncbi.nlm.nih.gov/gene/?term=54472 IL-1RAcPIP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015481 54472 TOLLIP http://www.ncbi.nlm.nih.gov/gene/?term=54472 IL-1RAcPIP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015482 544730 LOC544730 http://www.ncbi.nlm.nih.gov/gene/?term=544730 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015483 54475 NLE1 http://www.ncbi.nlm.nih.gov/gene/?term=54475 Nle mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015484 54476 RNF216 http://www.ncbi.nlm.nih.gov/gene/?term=54476 "CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015485 54476 RNF216 http://www.ncbi.nlm.nih.gov/gene/?term=54476 "CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015486 54476 RNF216 http://www.ncbi.nlm.nih.gov/gene/?term=54476 "CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015487 54478 FAM64A http://www.ncbi.nlm.nih.gov/gene/?term=54478 "CATS, RCS1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015488 54478 FAM64A http://www.ncbi.nlm.nih.gov/gene/?term=54478 "CATS, RCS1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015489 5447 POR http://www.ncbi.nlm.nih.gov/gene/?term=5447 "CPR, CYPOR, P450R " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015490 5447 POR http://www.ncbi.nlm.nih.gov/gene/?term=5447 "CPR, CYPOR, P450R " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015491 5447 POR http://www.ncbi.nlm.nih.gov/gene/?term=5447 "CPR, CYPOR, P450R " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015492 544800 Gm12346 http://www.ncbi.nlm.nih.gov/gene/?term=544800 "EG544800, OTTMUSG00000006249 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015493 54480 CHPF2 http://www.ncbi.nlm.nih.gov/gene/?term=54480 "CSGLCA-T, CSGlcAT, ChSy-3, chPF-2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015494 54480 CHPF2 http://www.ncbi.nlm.nih.gov/gene/?term=54480 "CSGLCA-T, CSGlcAT, ChSy-3, chPF-2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015495 54487 DGCR8 http://www.ncbi.nlm.nih.gov/gene/?term=54487 "C22orf12, DGCRK6, Gy1, pasha " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015496 54487 DGCR8 http://www.ncbi.nlm.nih.gov/gene/?term=54487 "C22orf12, DGCRK6, Gy1, pasha " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015497 544944 Cbx3-ps5 http://www.ncbi.nlm.nih.gov/gene/?term=544944 "EG544944, Gm5792 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015498 54494 C11orf71 http://www.ncbi.nlm.nih.gov/gene/?term=54494 URLC7 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015499 54494 C11orf71 http://www.ncbi.nlm.nih.gov/gene/?term=54494 URLC7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015500 54495 TMX3 http://www.ncbi.nlm.nih.gov/gene/?term=54495 "PDIA13, TXNDC10 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015501 544963 Iqgap2 http://www.ncbi.nlm.nih.gov/gene/?term=544963 "4933417J23Rik, A630053O10, AI788777 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015502 54496 PRMT7 http://www.ncbi.nlm.nih.gov/gene/?term=54496 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015503 54496 PRMT7 http://www.ncbi.nlm.nih.gov/gene/?term=54496 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015504 54496 PRMT7 http://www.ncbi.nlm.nih.gov/gene/?term=54496 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015505 54496 PRMT7 http://www.ncbi.nlm.nih.gov/gene/?term=54496 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015506 54496 PRMT7 http://www.ncbi.nlm.nih.gov/gene/?term=54496 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015507 54497 HEATR5B http://www.ncbi.nlm.nih.gov/gene/?term=54497 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015508 54497 HEATR5B http://www.ncbi.nlm.nih.gov/gene/?term=54497 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015509 54498 SMOX http://www.ncbi.nlm.nih.gov/gene/?term=54498 "C20orf16, PAO, PAO-1, PAO1, PAOH, PAOH1, SMO " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015510 54498 SMOX http://www.ncbi.nlm.nih.gov/gene/?term=54498 "C20orf16, PAO, PAO-1, PAO1, PAOH, PAOH1, SMO " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015511 54499 TMCO1 http://www.ncbi.nlm.nih.gov/gene/?term=54499 "HP10122, PCIA3, PNAS-136, TMCC4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015512 54499 TMCO1 http://www.ncbi.nlm.nih.gov/gene/?term=54499 "HP10122, PCIA3, PNAS-136, TMCC4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015513 54499 TMCO1 http://www.ncbi.nlm.nih.gov/gene/?term=54499 "HP10122, PCIA3, PNAS-136, TMCC4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015514 54502 RBM47 http://www.ncbi.nlm.nih.gov/gene/?term=54502 NET18 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015515 545039 Gm5799 http://www.ncbi.nlm.nih.gov/gene/?term=545039 EG545039 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015516 54503 ZDHHC13 http://www.ncbi.nlm.nih.gov/gene/?term=54503 "HIP14L, HIP3RP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015517 54503 ZDHHC13 http://www.ncbi.nlm.nih.gov/gene/?term=54503 "HIP14L, HIP3RP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015518 54507 ADAMTSL4 http://www.ncbi.nlm.nih.gov/gene/?term=54507 "ADAMTSL-4, ECTOL2, TSRC1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015519 54509 RHOF http://www.ncbi.nlm.nih.gov/gene/?term=54509 "ARHF, RIF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015520 54509 RHOF http://www.ncbi.nlm.nih.gov/gene/?term=54509 "ARHF, RIF " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015521 54509 RHOF http://www.ncbi.nlm.nih.gov/gene/?term=54509 "ARHF, RIF " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015522 545124 Tdg-ps http://www.ncbi.nlm.nih.gov/gene/?term=545124 "EG545124, Gm5806 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015523 54512 EXOSC4 http://www.ncbi.nlm.nih.gov/gene/?term=54512 "RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015524 54516 MTRF1L http://www.ncbi.nlm.nih.gov/gene/?term=54516 "HMRF1L, MRF1L, mtRF1a " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015525 54516 MTRF1L http://www.ncbi.nlm.nih.gov/gene/?term=54516 "HMRF1L, MRF1L, mtRF1a " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015526 54517 PUS7 http://www.ncbi.nlm.nih.gov/gene/?term=54517 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015527 54517 PUS7 http://www.ncbi.nlm.nih.gov/gene/?term=54517 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015528 54519 Apbb1ip http://www.ncbi.nlm.nih.gov/gene/?term=54519 "9930118P07Rik, Prp48 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015529 5451 POU2F1 http://www.ncbi.nlm.nih.gov/gene/?term=5451 "OCT1, OTF1, oct-1B " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015530 5451 POU2F1 http://www.ncbi.nlm.nih.gov/gene/?term=5451 "OCT1, OTF1, oct-1B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015531 54520 CCDC93 http://www.ncbi.nlm.nih.gov/gene/?term=54520 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015532 54520 CCDC93 http://www.ncbi.nlm.nih.gov/gene/?term=54520 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015533 54521 WDR44 http://www.ncbi.nlm.nih.gov/gene/?term=54521 "RAB11BP, RPH11 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015534 54521 WDR44 http://www.ncbi.nlm.nih.gov/gene/?term=54521 "RAB11BP, RPH11 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015535 54522 ANKRD16 http://www.ncbi.nlm.nih.gov/gene/?term=54522 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015536 54522 ANKRD16 http://www.ncbi.nlm.nih.gov/gene/?term=54522 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015537 54524 Syt6 http://www.ncbi.nlm.nih.gov/gene/?term=54524 "3110037A08Rik, AW048930, sytVI " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015538 54532 USP53 http://www.ncbi.nlm.nih.gov/gene/?term=54532 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015539 54532 USP53 http://www.ncbi.nlm.nih.gov/gene/?term=54532 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015540 54534 MRPL50 http://www.ncbi.nlm.nih.gov/gene/?term=54534 MRP-L50 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015541 54536 EXOC6 http://www.ncbi.nlm.nih.gov/gene/?term=54536 "EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015542 54537 FAM35A http://www.ncbi.nlm.nih.gov/gene/?term=54537 "FAM35A1, bA163M19.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015543 545389 Cep170 http://www.ncbi.nlm.nih.gov/gene/?term=545389 "4933426L22Rik, A330004A13Rik, AI195353 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015544 54539 NDUFB11 http://www.ncbi.nlm.nih.gov/gene/?term=54539 "CI-ESSS, ESSS, LSDMCA3, NP17.3, Np15, P17.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015545 54540 FAM193B http://www.ncbi.nlm.nih.gov/gene/?term=54540 IRIZIO mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015546 54541 DDIT4 http://www.ncbi.nlm.nih.gov/gene/?term=54541 "Dig2, REDD-1, REDD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015547 54541 DDIT4 http://www.ncbi.nlm.nih.gov/gene/?term=54541 "Dig2, REDD-1, REDD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015548 54542 RC3H2 http://www.ncbi.nlm.nih.gov/gene/?term=54542 "MNAB, RNF164 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015549 54542 RC3H2 http://www.ncbi.nlm.nih.gov/gene/?term=54542 "MNAB, RNF164 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015550 54543 TOMM7 http://www.ncbi.nlm.nih.gov/gene/?term=54543 TOM7 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015551 54543 TOMM7 http://www.ncbi.nlm.nih.gov/gene/?term=54543 TOM7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015552 54545 MTMR12 http://www.ncbi.nlm.nih.gov/gene/?term=54545 "3-PAP, PIP3AP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015553 54545 MTMR12 http://www.ncbi.nlm.nih.gov/gene/?term=54545 "3-PAP, PIP3AP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015554 54546 RNF186 http://www.ncbi.nlm.nih.gov/gene/?term=54546 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015555 545486 Tubb1 http://www.ncbi.nlm.nih.gov/gene/?term=545486 "2810484G07Rik, M(beta)1 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015556 54549 SDK2 http://www.ncbi.nlm.nih.gov/gene/?term=54549 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015557 545508 Gm5844 http://www.ncbi.nlm.nih.gov/gene/?term=545508 EG545508 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015558 54552 GNL3L http://www.ncbi.nlm.nih.gov/gene/?term=54552 GNL3B mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015559 54552 GNL3L http://www.ncbi.nlm.nih.gov/gene/?term=54552 GNL3B mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015560 545536 Gm10704 http://www.ncbi.nlm.nih.gov/gene/?term=545536 ENSMUSG00000074479 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015561 54554 WDR5B http://www.ncbi.nlm.nih.gov/gene/?term=54554 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015562 54554 WDR5B http://www.ncbi.nlm.nih.gov/gene/?term=54554 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015563 54555 DDX49 http://www.ncbi.nlm.nih.gov/gene/?term=54555 R27090_2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015564 54556 ING3 http://www.ncbi.nlm.nih.gov/gene/?term=54556 "Eaf4, ING2, MEAF4, p47ING3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015565 54557 SGTB http://www.ncbi.nlm.nih.gov/gene/?term=54557 SGT2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015566 54557 SGTB http://www.ncbi.nlm.nih.gov/gene/?term=54557 SGT2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015567 54557 SGTB http://www.ncbi.nlm.nih.gov/gene/?term=54557 SGT2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015568 54558 SPATA6 http://www.ncbi.nlm.nih.gov/gene/?term=54558 "HASH, SRF-1, SRF1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015569 545611 Fam205a2 http://www.ncbi.nlm.nih.gov/gene/?term=545611 "Fam205a, Gm13298, OTTMUSG00000011339 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015570 54561 Nap1l3 http://www.ncbi.nlm.nih.gov/gene/?term=54561 MB20 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015571 545640 Gm14138 http://www.ncbi.nlm.nih.gov/gene/?term=545640 OTTMUSG00000015767 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015572 54566 EPB41L4B http://www.ncbi.nlm.nih.gov/gene/?term=54566 "CG1, EHM2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015573 545677 Gm12888 http://www.ncbi.nlm.nih.gov/gene/?term=545677 OTTMUSG00000008911 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015574 54567 DLL4 http://www.ncbi.nlm.nih.gov/gene/?term=54567 "AOS6, hdelta2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015575 5457 POU4F1 http://www.ncbi.nlm.nih.gov/gene/?term=5457 "BRN3A, Oct-T1, RDC-1, brn-3A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015576 54583 EGLN1 http://www.ncbi.nlm.nih.gov/gene/?term=54583 "C1orf12, ECYT3, HALAH, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015577 54583 EGLN1 http://www.ncbi.nlm.nih.gov/gene/?term=54583 "C1orf12, ECYT3, HALAH, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6 " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00015578 54584 GNB1L http://www.ncbi.nlm.nih.gov/gene/?term=54584 "DGCRK3, FKSG1, GY2, WDR14, WDVCF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015579 54584 GNB1L http://www.ncbi.nlm.nih.gov/gene/?term=54584 "DGCRK3, FKSG1, GY2, WDR14, WDVCF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015580 54585 LZTFL1 http://www.ncbi.nlm.nih.gov/gene/?term=54585 BBS17 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015581 54585 LZTFL1 http://www.ncbi.nlm.nih.gov/gene/?term=54585 BBS17 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015582 545913 Zscan4d http://www.ncbi.nlm.nih.gov/gene/?term=545913 EG545913 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015583 545938 Zfp607 http://www.ncbi.nlm.nih.gov/gene/?term=545938 4732475C15Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015584 54596 L1TD1 http://www.ncbi.nlm.nih.gov/gene/?term=54596 ECAT11 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015585 54596 L1TD1 http://www.ncbi.nlm.nih.gov/gene/?term=54596 ECAT11 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015586 545 ATR http://www.ncbi.nlm.nih.gov/gene/?term=545 "FCTCS, FRP1, MEC1, SCKL, SCKL1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015587 545 ATR http://www.ncbi.nlm.nih.gov/gene/?term=545 "FCTCS, FRP1, MEC1, SCKL, SCKL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015588 546024 Crxos http://www.ncbi.nlm.nih.gov/gene/?term=546024 "AA606869, AY5908911, Egam1, Crxos " mRNA Mus musculus 15703187 Nucleus Embryonic tissue In situ hybridization|RT-PCR "We detected the expression in adult retina (postnatal day 30, P30) of Six3OS, Six6OS, Otx2OS, CrxOS and RaxOS (Fig. 3 and data not shown). In general, these transcripts were all expressed at higher levels in the inner nuclear layer (INL) and in the ganglion cell layer (GCL). " RLID00015589 54602 NDFIP2 http://www.ncbi.nlm.nih.gov/gene/?term=54602 N4WBP5A mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015590 54602 NDFIP2 http://www.ncbi.nlm.nih.gov/gene/?term=54602 N4WBP5A mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015591 54604 Pcnx http://www.ncbi.nlm.nih.gov/gene/?term=54604 "2900024E21Rik, 3526401J03Rik, AF096286, AI327143, AI413187l1, Pcnx " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015592 54606 DDX56 http://www.ncbi.nlm.nih.gov/gene/?term=54606 "DDX21, DDX26, NOH61 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015593 54606 DDX56 http://www.ncbi.nlm.nih.gov/gene/?term=54606 "DDX21, DDX26, NOH61 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015594 54609 Ubqln2 http://www.ncbi.nlm.nih.gov/gene/?term=54609 "Chap1, Dsk2, HRIHFB2157, Plic-2, Plic2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015595 54614 Prpf40b http://www.ncbi.nlm.nih.gov/gene/?term=54614 "2610317D23Rik, Hypc " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015596 546157 7420426K07Rik http://www.ncbi.nlm.nih.gov/gene/?term=546157 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015597 546165 Gm10608 http://www.ncbi.nlm.nih.gov/gene/?term=546165 "EG546165, ENSMUSG00000074029 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015598 54617 INO80 http://www.ncbi.nlm.nih.gov/gene/?term=54617 "INO80A, INOC1, hINO80 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015599 54617 INO80 http://www.ncbi.nlm.nih.gov/gene/?term=54617 "INO80A, INOC1, hINO80 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015600 54622 ARL15 http://www.ncbi.nlm.nih.gov/gene/?term=54622 ARFRP2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015601 54623 PAF1 http://www.ncbi.nlm.nih.gov/gene/?term=54623 "F23149_1, PD2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015602 54625 PARP14 http://www.ncbi.nlm.nih.gov/gene/?term=54625 "ARTD8, BAL2, PARP-14, pART8 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015603 54625 PARP14 http://www.ncbi.nlm.nih.gov/gene/?term=54625 "ARTD8, BAL2, PARP-14, pART8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015604 54625 PARP14 http://www.ncbi.nlm.nih.gov/gene/?term=54625 "ARTD8, BAL2, PARP-14, pART8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015605 54629 FAM63B http://www.ncbi.nlm.nih.gov/gene/?term=54629 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015606 546321 Gm15365 http://www.ncbi.nlm.nih.gov/gene/?term=546321 "EG546321, OTTMUSG00000020738 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015607 54633 Pqbp1 http://www.ncbi.nlm.nih.gov/gene/?term=54633 "PQBP-1, Sfc2, npw38 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015608 54644 Otud5 http://www.ncbi.nlm.nih.gov/gene/?term=54644 "AA407879, AI553596, BB114028, DUBA, DXImx46e, Sfc7 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015609 54646 Ppp1r3f http://www.ncbi.nlm.nih.gov/gene/?term=54646 "DXImx48e, R3F, RF3, Sfc15 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015610 5464 PPA1 http://www.ncbi.nlm.nih.gov/gene/?term=5464 "HEL-S-66p, IOPPP, PP, PP1, SID6-8061 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015611 5464 PPA1 http://www.ncbi.nlm.nih.gov/gene/?term=5464 "HEL-S-66p, IOPPP, PP, PP1, SID6-8061 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015612 5464 PPA1 http://www.ncbi.nlm.nih.gov/gene/?term=5464 "HEL-S-66p, IOPPP, PP, PP1, SID6-8061 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015613 54662 TBC1D13 http://www.ncbi.nlm.nih.gov/gene/?term=54662 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015614 54663 WDR74 http://www.ncbi.nlm.nih.gov/gene/?term=54663 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015615 54663 WDR74 http://www.ncbi.nlm.nih.gov/gene/?term=54663 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015616 54664 TMEM106B http://www.ncbi.nlm.nih.gov/gene/?term=54664 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015617 54675 CRLS1 http://www.ncbi.nlm.nih.gov/gene/?term=54675 "C20orf155, CLS, CLS1, GCD10, dJ967N21.6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015618 54675 CRLS1 http://www.ncbi.nlm.nih.gov/gene/?term=54675 "C20orf155, CLS, CLS1, GCD10, dJ967N21.6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015619 54676 GTPBP2 http://www.ncbi.nlm.nih.gov/gene/?term=54676 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015620 5467 PPARD http://www.ncbi.nlm.nih.gov/gene/?term=5467 "FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015621 54681 P4HTM http://www.ncbi.nlm.nih.gov/gene/?term=54681 "EGLN4, HIFPH4, P4H-TM, PH-4, PH4, PHD4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015622 5468 PPARG http://www.ncbi.nlm.nih.gov/gene/?term=5468 "CIMT1, GLM1, NR1C31, PPARG2, PPARgamma, PPARG " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015623 54700 RRN3 http://www.ncbi.nlm.nih.gov/gene/?term=54700 "A-270G1.2, TIFIA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015624 54704 PDP1 http://www.ncbi.nlm.nih.gov/gene/?term=54704 "PDH, PDP, PDPC, PPM2A, PPM2C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015625 54707 GPN2 http://www.ncbi.nlm.nih.gov/gene/?term=54707 ATPBD1B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015626 54708 MARCH5 http://www.ncbi.nlm.nih.gov/gene/?term=54708 "MARCH-V, MITOL, RNF153 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015627 54709 Eif3i http://www.ncbi.nlm.nih.gov/gene/?term=54709 "36kDa, D4Ertd632e, Eif3s2, Trip1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015628 54715 RBFOX1 http://www.ncbi.nlm.nih.gov/gene/?term=54715 "2BP1, A2BP1, FOX-1, FOX1, HRNBP1 " mRNA Homo sapiens 26687839 Cytoplasm Hippocampus cortex Microarray "To investigate the function of cytoplasmic Rbfox1, we knocked down Rbfox proteins in mouse neurons and rescued with cytoplasmic or nuclear Rbfox1. Transcriptome profiling showed that nuclear Rbfox1 rescued splicing changes, whereas cytoplasmic Rbfox1 rescued changes in mRNA levels. " RLID00015629 54715 RBFOX1 http://www.ncbi.nlm.nih.gov/gene/?term=54715 "2BP1, A2BP1, FOX-1, FOX1, HRNBP1 " mRNA Homo sapiens 26687839 Nucleus Hippocampus cortex Microarray "To investigate the function of cytoplasmic Rbfox1, we knocked down Rbfox proteins in mouse neurons and rescued with cytoplasmic or nuclear Rbfox1. Transcriptome profiling showed that nuclear Rbfox1 rescued splicing changes, whereas cytoplasmic Rbfox1 rescued changes in mRNA levels. " RLID00015630 54716 SLC6A20 http://www.ncbi.nlm.nih.gov/gene/?term=54716 "SIT1, XT3, Xtrp3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015631 5471 PPAT http://www.ncbi.nlm.nih.gov/gene/?term=5471 "ATASE, GPAT, PRAT " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015632 54720 Rcan1 http://www.ncbi.nlm.nih.gov/gene/?term=54720 "Adapt78, CALP1L, CSP1, DSC1, Dscr1, MCIP1, RCN1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015633 54723 Tfip11 http://www.ncbi.nlm.nih.gov/gene/?term=54723 "2810002G02Rik, AF097181, AW046167, Srr1, TIP33, Tip39 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015634 54725 Cadm1 http://www.ncbi.nlm.nih.gov/gene/?term=54725 "2900073G06Rik, 3100001I08Rik, AI987920, Bl2, Igsf4, Igsf4a, Necl2, RA175, RA175A, RA175B, RA175C, RA175N, ST17, SgIGSF, SynCam, Tslc1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015635 54725 Cadm1 http://www.ncbi.nlm.nih.gov/gene/?term=54725 "2900073G06Rik, 3100001I08Rik, AI987920, Bl2, Igsf4, Igsf4a, Necl2, RA175, RA175A, RA175B, RA175C, RA175N, ST17, SgIGSF, SynCam, Tslc1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00015636 54726 OTUD4 http://www.ncbi.nlm.nih.gov/gene/?term=54726 "DUBA6, HIN1, HSHIN1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015637 54732 TMED9 http://www.ncbi.nlm.nih.gov/gene/?term=54732 "GMP25, HSGP25L2G, p24a2, p25 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015638 54732 TMED9 http://www.ncbi.nlm.nih.gov/gene/?term=54732 "GMP25, HSGP25L2G, p24a2, p25 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015639 54732 TMED9 http://www.ncbi.nlm.nih.gov/gene/?term=54732 "GMP25, HSGP25L2G, p24a2, p25 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015640 54733 SLC35F2 http://www.ncbi.nlm.nih.gov/gene/?term=54733 HSNOV1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015641 54734 RAB39A http://www.ncbi.nlm.nih.gov/gene/?term=54734 RAB39 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015642 54734 RAB39A http://www.ncbi.nlm.nih.gov/gene/?term=54734 RAB39 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015643 54737 MPHOSPH8 http://www.ncbi.nlm.nih.gov/gene/?term=54737 "HSMPP8, TWA3, mpp8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015644 54737 MPHOSPH8 http://www.ncbi.nlm.nih.gov/gene/?term=54737 "HSMPP8, TWA3, mpp8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015645 54741 LEPROT http://www.ncbi.nlm.nih.gov/gene/?term=54741 "LEPR, OB-RGRP, OBRGRP, VPS55 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015646 54741 LEPROT http://www.ncbi.nlm.nih.gov/gene/?term=54741 "LEPR, OB-RGRP, OBRGRP, VPS55 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015647 54749 EPDR1 http://www.ncbi.nlm.nih.gov/gene/?term=54749 "EPDR, MERP-1, MERP1, UCC1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015648 54751 FBLIM1 http://www.ncbi.nlm.nih.gov/gene/?term=54751 "CAL, FBLP-1, FBLP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015649 54751 FBLIM1 http://www.ncbi.nlm.nih.gov/gene/?term=54751 "CAL, FBLP-1, FBLP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015650 54756 IL17RD http://www.ncbi.nlm.nih.gov/gene/?term=54756 "HH18, IL-17RD, IL17RLM, SEF " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015651 54756 IL17RD http://www.ncbi.nlm.nih.gov/gene/?term=54756 "HH18, IL-17RD, IL17RLM, SEF " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015652 54758 KLHDC4 http://www.ncbi.nlm.nih.gov/gene/?term=54758 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015653 54758 KLHDC4 http://www.ncbi.nlm.nih.gov/gene/?term=54758 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015654 54760 PCSK4 http://www.ncbi.nlm.nih.gov/gene/?term=54760 "PC4, SPC5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015655 54764 ZRANB1 http://www.ncbi.nlm.nih.gov/gene/?term=54764 TRABID mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015656 54764 ZRANB1 http://www.ncbi.nlm.nih.gov/gene/?term=54764 TRABID mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015657 54765 TRIM44 http://www.ncbi.nlm.nih.gov/gene/?term=54765 "DIPB, HSA249128, MC7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015658 54765 TRIM44 http://www.ncbi.nlm.nih.gov/gene/?term=54765 "DIPB, HSA249128, MC7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015659 5476 CTSA http://www.ncbi.nlm.nih.gov/gene/?term=5476 "GLB2, GSL, NGBE, PPCA, PPGB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015660 5476 CTSA http://www.ncbi.nlm.nih.gov/gene/?term=5476 "GLB2, GSL, NGBE, PPCA, PPGB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015661 5476 CTSA http://www.ncbi.nlm.nih.gov/gene/?term=5476 "GLB2, GSL, NGBE, PPCA, PPGB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015662 54776 PPP1R12C http://www.ncbi.nlm.nih.gov/gene/?term=54776 "LENG3, MBS85, p84, p85 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015663 54778 RNF111 http://www.ncbi.nlm.nih.gov/gene/?term=54778 ARK mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015664 54778 RNF111 http://www.ncbi.nlm.nih.gov/gene/?term=54778 ARK mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015665 547814 FAD2-1 http://www.ncbi.nlm.nih.gov/gene/?term=547814 GLYMA_10G278000 mRNA Glycine max 21173264 Nucleus Seedling Next-generation sequencing "However, expression of an inverted-repeat double-stranded RNA corresponding to the soybean FAD2-1A desaturase intron is sufficient to silence FAD2-1, implicating nuclear precursor mRNA (pre-mRNA) rather than cytosolic mRNA as the target of PTGS. " RLID00015666 54784 ALKBH4 http://www.ncbi.nlm.nih.gov/gene/?term=54784 ABH4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015667 54785 BORCS6 http://www.ncbi.nlm.nih.gov/gene/?term=54785 "C17orf59, PRO2472 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015668 54788 DNAJB12 http://www.ncbi.nlm.nih.gov/gene/?term=54788 DJ10 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015669 54788 DNAJB12 http://www.ncbi.nlm.nih.gov/gene/?term=54788 DJ10 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015670 5478 PPIA http://www.ncbi.nlm.nih.gov/gene/?term=5478 "CYPA, CYPH, HEL-S-69p " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015671 5478 PPIA http://www.ncbi.nlm.nih.gov/gene/?term=5478 "CYPA, CYPH, HEL-S-69p " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015672 54790 TET2 http://www.ncbi.nlm.nih.gov/gene/?term=54790 "KIAA1546, MDS " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015673 54797 MED18 http://www.ncbi.nlm.nih.gov/gene/?term=54797 p28b mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015674 54797 MED18 http://www.ncbi.nlm.nih.gov/gene/?term=54797 p28b mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015675 54797 MED18 http://www.ncbi.nlm.nih.gov/gene/?term=54797 p28b mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015676 54799 MBTD1 http://www.ncbi.nlm.nih.gov/gene/?term=54799 SA49P01 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015677 5479 PPIB http://www.ncbi.nlm.nih.gov/gene/?term=5479 "CYP-S1, CYPB, HEL-S-39, OI9, SCYLP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015678 5479 PPIB http://www.ncbi.nlm.nih.gov/gene/?term=5479 "CYP-S1, CYPB, HEL-S-39, OI9, SCYLP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015679 54800 KLHL24 http://www.ncbi.nlm.nih.gov/gene/?term=54800 "DRE1, KRIP6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015680 54800 KLHL24 http://www.ncbi.nlm.nih.gov/gene/?term=54800 "DRE1, KRIP6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015681 54800 KLHL24 http://www.ncbi.nlm.nih.gov/gene/?term=54800 "DRE1, KRIP6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015682 54800 KLHL24 http://www.ncbi.nlm.nih.gov/gene/?term=54800 "DRE1, KRIP6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015683 54801 HAUS6 http://www.ncbi.nlm.nih.gov/gene/?term=54801 "Dgt6, FAM29A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015684 54801 HAUS6 http://www.ncbi.nlm.nih.gov/gene/?term=54801 "Dgt6, FAM29A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015685 54802 TRIT1 http://www.ncbi.nlm.nih.gov/gene/?term=54802 "GRO1, IPPT, IPT, IPTase, MOD5, hGRO1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015686 54802 TRIT1 http://www.ncbi.nlm.nih.gov/gene/?term=54802 "GRO1, IPPT, IPT, IPTase, MOD5, hGRO1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015687 54802 TRIT1 http://www.ncbi.nlm.nih.gov/gene/?term=54802 "GRO1, IPPT, IPT, IPTase, MOD5, hGRO1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015688 54805 CNNM2 http://www.ncbi.nlm.nih.gov/gene/?term=54805 "ACDP2, HOMG6, HOMGSMR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015689 54805 CNNM2 http://www.ncbi.nlm.nih.gov/gene/?term=54805 "ACDP2, HOMG6, HOMGSMR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015690 54806 AHI1 http://www.ncbi.nlm.nih.gov/gene/?term=54806 "AHI-1, JBTS3, ORF1, dJ71N10.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015691 54808 DYM http://www.ncbi.nlm.nih.gov/gene/?term=54808 "DMC, SMC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015692 5480 PPIC http://www.ncbi.nlm.nih.gov/gene/?term=5480 CYPC mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015693 5480 PPIC http://www.ncbi.nlm.nih.gov/gene/?term=5480 CYPC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015694 54811 ZNF562 http://www.ncbi.nlm.nih.gov/gene/?term=54811 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015695 54812 AFTPH http://www.ncbi.nlm.nih.gov/gene/?term=54812 Nbla10388 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015696 54815 GATAD2A http://www.ncbi.nlm.nih.gov/gene/?term=54815 p66alpha mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015697 54816 ZNF280D http://www.ncbi.nlm.nih.gov/gene/?term=54816 "SUHW4, ZNF634 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015698 54819 ZCCHC10 http://www.ncbi.nlm.nih.gov/gene/?term=54819 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015699 5481 PPID http://www.ncbi.nlm.nih.gov/gene/?term=5481 "CYP-40, CYPD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015700 5481 PPID http://www.ncbi.nlm.nih.gov/gene/?term=5481 "CYP-40, CYPD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015701 5481 PPID http://www.ncbi.nlm.nih.gov/gene/?term=5481 "CYP-40, CYPD " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015702 5481 PPID http://www.ncbi.nlm.nih.gov/gene/?term=5481 "CYP-40, CYPD " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015703 5481 PPID http://www.ncbi.nlm.nih.gov/gene/?term=5481 "CYP-40, CYPD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015704 54822 TRPM7 http://www.ncbi.nlm.nih.gov/gene/?term=54822 "ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015705 54825 CDHR2 http://www.ncbi.nlm.nih.gov/gene/?term=54825 "PCDH24, PCLKC " mRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00015706 54828 BCAS3 http://www.ncbi.nlm.nih.gov/gene/?term=54828 "GAOB1, MAAB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015707 548313 SSX4B http://www.ncbi.nlm.nih.gov/gene/?term=548313 CT5.4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015708 54832 VPS13C http://www.ncbi.nlm.nih.gov/gene/?term=54832 PARK23 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015709 54832 VPS13C http://www.ncbi.nlm.nih.gov/gene/?term=54832 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015710 54834 GDAP2 http://www.ncbi.nlm.nih.gov/gene/?term=54834 MACROD3 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015711 54834 GDAP2 http://www.ncbi.nlm.nih.gov/gene/?term=54834 MACROD3 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015712 54834 GDAP2 http://www.ncbi.nlm.nih.gov/gene/?term=54834 MACROD3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015713 54836 BSPRY http://www.ncbi.nlm.nih.gov/gene/?term=54836 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015714 54836 BSPRY http://www.ncbi.nlm.nih.gov/gene/?term=54836 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015715 54841 BIVM http://www.ncbi.nlm.nih.gov/gene/?term=54841 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015716 54841 BIVM http://www.ncbi.nlm.nih.gov/gene/?term=54841 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015717 54841 BIVM http://www.ncbi.nlm.nih.gov/gene/?term=54841 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015718 54841 BIVM http://www.ncbi.nlm.nih.gov/gene/?term=54841 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015719 54842 MFSD6 http://www.ncbi.nlm.nih.gov/gene/?term=54842 "MMR2, hMMR2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015720 54845 ESRP1 http://www.ncbi.nlm.nih.gov/gene/?term=54845 "RBM35A, RMB35A " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015721 54849 DEF8 http://www.ncbi.nlm.nih.gov/gene/?term=54849 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015722 54849 DEF8 http://www.ncbi.nlm.nih.gov/gene/?term=54849 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015723 54850 FBXL12 http://www.ncbi.nlm.nih.gov/gene/?term=54850 Fbl12 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015724 54850 FBXL12 http://www.ncbi.nlm.nih.gov/gene/?term=54850 Fbl12 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015725 54852 PAQR5 http://www.ncbi.nlm.nih.gov/gene/?term=54852 MPRG mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015726 54852 PAQR5 http://www.ncbi.nlm.nih.gov/gene/?term=54852 MPRG mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015727 54852 PAQR5 http://www.ncbi.nlm.nih.gov/gene/?term=54852 MPRG mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015728 54853 WDR55 http://www.ncbi.nlm.nih.gov/gene/?term=54853 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015729 54853 WDR55 http://www.ncbi.nlm.nih.gov/gene/?term=54853 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015730 54855 FAM46C http://www.ncbi.nlm.nih.gov/gene/?term=54855 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015731 54856 GON4L http://www.ncbi.nlm.nih.gov/gene/?term=54856 "GON-4, GON4, YARP " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015732 54856 GON4L http://www.ncbi.nlm.nih.gov/gene/?term=54856 "GON-4, GON4, YARP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015733 54856 GON4L http://www.ncbi.nlm.nih.gov/gene/?term=54856 "GON-4, GON4, YARP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015734 54858 PGPEP1 http://www.ncbi.nlm.nih.gov/gene/?term=54858 "PAP-I, PGP, PGP-I, PGPI, Pcp " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015735 54858 PGPEP1 http://www.ncbi.nlm.nih.gov/gene/?term=54858 "PAP-I, PGP, PGP-I, PGPI, Pcp " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015736 54858 PGPEP1 http://www.ncbi.nlm.nih.gov/gene/?term=54858 "PAP-I, PGP, PGP-I, PGPI, Pcp " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015737 54859 ELP6 http://www.ncbi.nlm.nih.gov/gene/?term=54859 "C3orf75, TMEM103 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015738 54859 ELP6 http://www.ncbi.nlm.nih.gov/gene/?term=54859 "C3orf75, TMEM103 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015739 54861 SNRK http://www.ncbi.nlm.nih.gov/gene/?term=54861 HSNFRK mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015740 54863 TOR4A http://www.ncbi.nlm.nih.gov/gene/?term=54863 C9orf167 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015741 54863 TOR4A http://www.ncbi.nlm.nih.gov/gene/?term=54863 C9orf167 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015742 54863 TOR4A http://www.ncbi.nlm.nih.gov/gene/?term=54863 C9orf167 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015743 548644 POLR2J3 http://www.ncbi.nlm.nih.gov/gene/?term=548644 "POLR2J2, RPB11b1, RPB11b2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015744 548644 POLR2J3 http://www.ncbi.nlm.nih.gov/gene/?term=548644 "POLR2J2, RPB11b1, RPB11b2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015745 548644 POLR2J3 http://www.ncbi.nlm.nih.gov/gene/?term=548644 "POLR2J2, RPB11b1, RPB11b2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015746 54865 GPATCH4 http://www.ncbi.nlm.nih.gov/gene/?term=54865 GPATC4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015747 54865 GPATCH4 http://www.ncbi.nlm.nih.gov/gene/?term=54865 GPATC4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015748 54866 PPP1R14D http://www.ncbi.nlm.nih.gov/gene/?term=54866 "CPI17-like, GBPI-1, GBPI1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015749 54866 PPP1R14D http://www.ncbi.nlm.nih.gov/gene/?term=54866 "CPI17-like, GBPI-1, GBPI1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015750 54867 TMEM214 http://www.ncbi.nlm.nih.gov/gene/?term=54867 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015751 54867 TMEM214 http://www.ncbi.nlm.nih.gov/gene/?term=54867 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015752 54868 TMEM104 http://www.ncbi.nlm.nih.gov/gene/?term=54868 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015753 54869 EPS8L1 http://www.ncbi.nlm.nih.gov/gene/?term=54869 "DRC3, EPS8R1, PP10566 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015754 54870 QRICH1 http://www.ncbi.nlm.nih.gov/gene/?term=54870 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015755 54870 QRICH1 http://www.ncbi.nlm.nih.gov/gene/?term=54870 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015756 54872 PIGG http://www.ncbi.nlm.nih.gov/gene/?term=54872 "GPI7, LAS21, PRO4405, RLGS1930 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015757 54872 PIGG http://www.ncbi.nlm.nih.gov/gene/?term=54872 "GPI7, LAS21, PRO4405, RLGS1930 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015758 54873 PALMD http://www.ncbi.nlm.nih.gov/gene/?term=54873 "C1orf11, PALML " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015759 54874 FNBP1L http://www.ncbi.nlm.nih.gov/gene/?term=54874 "C1orf39, TOCA1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015760 54876 DCAF16 http://www.ncbi.nlm.nih.gov/gene/?term=54876 C4orf30 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015761 54876 DCAF16 http://www.ncbi.nlm.nih.gov/gene/?term=54876 C4orf30 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015762 54878 DPP8 http://www.ncbi.nlm.nih.gov/gene/?term=54878 "DP8, DPRP-1, DPRP1, MST097, MSTP097, MSTP135, MSTP141 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015763 54879 ST7L http://www.ncbi.nlm.nih.gov/gene/?term=54879 "FAM4B, ST7R, STLR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015764 54881 TEX10 http://www.ncbi.nlm.nih.gov/gene/?term=54881 "Ipi1, bA208F1.2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015765 54882 ANKHD1 http://www.ncbi.nlm.nih.gov/gene/?term=54882 "MASK, MASK1, PP2500, VBARP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015766 54882 ANKHD1 http://www.ncbi.nlm.nih.gov/gene/?term=54882 "MASK, MASK1, PP2500, VBARP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015767 54883 CWC25 http://www.ncbi.nlm.nih.gov/gene/?term=54883 CCDC49 mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00015768 54884 RETSAT http://www.ncbi.nlm.nih.gov/gene/?term=54884 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015769 54884 RETSAT http://www.ncbi.nlm.nih.gov/gene/?term=54884 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015770 54884 RETSAT http://www.ncbi.nlm.nih.gov/gene/?term=54884 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015771 54887 UHRF1BP1 http://www.ncbi.nlm.nih.gov/gene/?term=54887 "C6orf107, ICBP90, dJ349A12.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015772 54888 NSUN2 http://www.ncbi.nlm.nih.gov/gene/?term=54888 "MISU, MRT5, SAKI, TRM4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015773 54890 ALKBH5 http://www.ncbi.nlm.nih.gov/gene/?term=54890 "ABH5, OFOXD, OFOXD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015774 54892 NCAPG2 http://www.ncbi.nlm.nih.gov/gene/?term=54892 "CAP-G2, CAPG2, LUZP5, MTB, hCAP-G2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015775 54892 NCAPG2 http://www.ncbi.nlm.nih.gov/gene/?term=54892 "CAP-G2, CAPG2, LUZP5, MTB, hCAP-G2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015776 54893 MTMR10 http://www.ncbi.nlm.nih.gov/gene/?term=54893 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015777 54894 RNF43 http://www.ncbi.nlm.nih.gov/gene/?term=54894 "RNF124, URCC " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015778 54898 ELOVL2 http://www.ncbi.nlm.nih.gov/gene/?term=54898 SSC2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015779 54899 PXK http://www.ncbi.nlm.nih.gov/gene/?term=54899 MONaKA mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015780 54899 PXK http://www.ncbi.nlm.nih.gov/gene/?term=54899 MONaKA mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015781 54902 TTC19 http://www.ncbi.nlm.nih.gov/gene/?term=54902 "2010204O13Rik, MC3DN2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015782 54902 TTC19 http://www.ncbi.nlm.nih.gov/gene/?term=54902 "2010204O13Rik, MC3DN2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015783 54903 MKS1 http://www.ncbi.nlm.nih.gov/gene/?term=54903 "BBS13, MES, MKS, POC12 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015784 54904 WHSC1L1 http://www.ncbi.nlm.nih.gov/gene/?term=54904 "NSD3, WHISTLE, pp14328 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015785 54906 FAM208B http://www.ncbi.nlm.nih.gov/gene/?term=54906 "C10orf18, bA318E3.2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015786 54906 FAM208B http://www.ncbi.nlm.nih.gov/gene/?term=54906 "C10orf18, bA318E3.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015787 54913 RPP25 http://www.ncbi.nlm.nih.gov/gene/?term=54913 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015788 54913 RPP25 http://www.ncbi.nlm.nih.gov/gene/?term=54913 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015789 54914 FOCAD http://www.ncbi.nlm.nih.gov/gene/?term=54914 KIAA1797 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015790 54916 TMEM260 http://www.ncbi.nlm.nih.gov/gene/?term=54916 C14orf101 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015791 54918 CMTM6 http://www.ncbi.nlm.nih.gov/gene/?term=54918 "CKLFSF6, PRO2219 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015792 54919 DNAAF5 http://www.ncbi.nlm.nih.gov/gene/?term=54919 "CILD18, HEATR2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015793 54919 DNAAF5 http://www.ncbi.nlm.nih.gov/gene/?term=54919 "CILD18, HEATR2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015794 54920 DUS2 http://www.ncbi.nlm.nih.gov/gene/?term=54920 "DUS2L, SMM1, URLC8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015795 54920 DUS2 http://www.ncbi.nlm.nih.gov/gene/?term=54920 "DUS2L, SMM1, URLC8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015796 54921 CHTF8 http://www.ncbi.nlm.nih.gov/gene/?term=54921 "CTF8, DERPC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015797 54921 CHTF8 http://www.ncbi.nlm.nih.gov/gene/?term=54921 "CTF8, DERPC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015798 54925 ZSCAN32 http://www.ncbi.nlm.nih.gov/gene/?term=54925 "HCCS-5, ZNF434 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015799 54926 UBE2R2 http://www.ncbi.nlm.nih.gov/gene/?term=54926 "CDC34B, E2-CDC34B, UBC3B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015800 54928 IMPAD1 http://www.ncbi.nlm.nih.gov/gene/?term=54928 "GPAPP, IMP 3, IMP-3, IMPA3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015801 54928 IMPAD1 http://www.ncbi.nlm.nih.gov/gene/?term=54928 "GPAPP, IMP 3, IMP-3, IMPA3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015802 54930 HAUS4 http://www.ncbi.nlm.nih.gov/gene/?term=54930 C14orf94 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015803 54931 TRMT10C http://www.ncbi.nlm.nih.gov/gene/?term=54931 "HNYA, MRPP1, RG9MTD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015804 54931 TRMT10C http://www.ncbi.nlm.nih.gov/gene/?term=54931 "HNYA, MRPP1, RG9MTD1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015805 54935 DUSP23 http://www.ncbi.nlm.nih.gov/gene/?term=54935 "DUSP25, LDP-3, MOSP, VHZ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015806 54936 ADPRHL2 http://www.ncbi.nlm.nih.gov/gene/?term=54936 ARH3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015807 54938 SARS2 http://www.ncbi.nlm.nih.gov/gene/?term=54938 "SARS, SARSM, SERS, SYS, SerRS, SerRSmt, mtSerRS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015808 54939 COMMD4 http://www.ncbi.nlm.nih.gov/gene/?term=54939 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015809 54939 COMMD4 http://www.ncbi.nlm.nih.gov/gene/?term=54939 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015810 54939 COMMD4 http://www.ncbi.nlm.nih.gov/gene/?term=54939 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015811 54940 OCIAD1 http://www.ncbi.nlm.nih.gov/gene/?term=54940 "ASRIJ, OCIA, TPA018 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015812 54940 OCIAD1 http://www.ncbi.nlm.nih.gov/gene/?term=54940 "ASRIJ, OCIA, TPA018 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015813 54941 RNF125 http://www.ncbi.nlm.nih.gov/gene/?term=54941 "TNORS, TRAC-1, TRAC1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015814 54941 RNF125 http://www.ncbi.nlm.nih.gov/gene/?term=54941 "TNORS, TRAC-1, TRAC1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015815 54942 FAM206A http://www.ncbi.nlm.nih.gov/gene/?term=54942 "C9orf6, CG-8, Simiate " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015816 54942 FAM206A http://www.ncbi.nlm.nih.gov/gene/?term=54942 "C9orf6, CG-8, Simiate " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015817 54946 SLC41A3 http://www.ncbi.nlm.nih.gov/gene/?term=54946 SLC41A1-L2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015818 54947 LPCAT2 http://www.ncbi.nlm.nih.gov/gene/?term=54947 "AGPAT11, AYTL1, LysoPAFAT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015819 54947 LPCAT2 http://www.ncbi.nlm.nih.gov/gene/?term=54947 "AGPAT11, AYTL1, LysoPAFAT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015820 54947 LPCAT2 http://www.ncbi.nlm.nih.gov/gene/?term=54947 "AGPAT11, AYTL1, LysoPAFAT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015821 54948 MRPL16 http://www.ncbi.nlm.nih.gov/gene/?term=54948 "L16mt, MRP-L16, PNAS-111 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015822 54948 MRPL16 http://www.ncbi.nlm.nih.gov/gene/?term=54948 "L16mt, MRP-L16, PNAS-111 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015823 54951 COMMD8 http://www.ncbi.nlm.nih.gov/gene/?term=54951 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015824 54952 TRNAU1AP http://www.ncbi.nlm.nih.gov/gene/?term=54952 "PRO1902, SECP43, TRSPAP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015825 54952 TRNAU1AP http://www.ncbi.nlm.nih.gov/gene/?term=54952 "PRO1902, SECP43, TRSPAP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015826 54952 TRNAU1AP http://www.ncbi.nlm.nih.gov/gene/?term=54952 "PRO1902, SECP43, TRSPAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015827 54955 C1orf109 http://www.ncbi.nlm.nih.gov/gene/?term=54955 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015828 549573 gdf1 http://www.ncbi.nlm.nih.gov/gene/?term=549573 "dvr-1, dvr1, gdf-1, gdf3, vg-1, vg1 " mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00015829 54957 TXNL4B http://www.ncbi.nlm.nih.gov/gene/?term=54957 "DLP, Dim2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015830 54957 TXNL4B http://www.ncbi.nlm.nih.gov/gene/?term=54957 "DLP, Dim2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015831 54957 TXNL4B http://www.ncbi.nlm.nih.gov/gene/?term=54957 "DLP, Dim2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015832 54958 TMEM160 http://www.ncbi.nlm.nih.gov/gene/?term=54958 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015833 5495 PPM1B http://www.ncbi.nlm.nih.gov/gene/?term=5495 "PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015834 54960 GEMIN8 http://www.ncbi.nlm.nih.gov/gene/?term=54960 FAM51A1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015835 54960 GEMIN8 http://www.ncbi.nlm.nih.gov/gene/?term=54960 FAM51A1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015836 54962 TIPIN http://www.ncbi.nlm.nih.gov/gene/?term=54962 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015837 54962 TIPIN http://www.ncbi.nlm.nih.gov/gene/?term=54962 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015838 54963 UCKL1 http://www.ncbi.nlm.nih.gov/gene/?term=54963 "UCK1L, URKL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015839 54964 C1orf56 http://www.ncbi.nlm.nih.gov/gene/?term=54964 MENT mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015840 54965 PIGX http://www.ncbi.nlm.nih.gov/gene/?term=54965 PIG-X mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015841 54965 PIGX http://www.ncbi.nlm.nih.gov/gene/?term=54965 PIG-X mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015842 54965 PIGX http://www.ncbi.nlm.nih.gov/gene/?term=54965 PIG-X mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015843 54968 TMEM70 http://www.ncbi.nlm.nih.gov/gene/?term=54968 MC5DN2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015844 54968 TMEM70 http://www.ncbi.nlm.nih.gov/gene/?term=54968 MC5DN2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015845 54969 HPF1 http://www.ncbi.nlm.nih.gov/gene/?term=54969 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015846 5496 PPM1G http://www.ncbi.nlm.nih.gov/gene/?term=5496 "PP2CG, PP2CGAMMA, PPP2CG " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015847 5496 PPM1G http://www.ncbi.nlm.nih.gov/gene/?term=5496 "PP2CG, PP2CGAMMA, PPP2CG " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015848 5496 PPM1G http://www.ncbi.nlm.nih.gov/gene/?term=5496 "PP2CG, PP2CGAMMA, PPP2CG " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015849 5496 PPM1G http://www.ncbi.nlm.nih.gov/gene/?term=5496 "PP2CG, PP2CGAMMA, PPP2CG " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015850 5496 PPM1G http://www.ncbi.nlm.nih.gov/gene/?term=5496 "PP2CG, PP2CGAMMA, PPP2CG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015851 54971 BANP http://www.ncbi.nlm.nih.gov/gene/?term=54971 "BEND1, SMAR1, SMARBP1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015852 54972 TMEM132A http://www.ncbi.nlm.nih.gov/gene/?term=54972 "GBP, HSPA5BP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015853 54974 THG1L http://www.ncbi.nlm.nih.gov/gene/?term=54974 "ICF45, IHG-1, hTHG1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015854 54974 THG1L http://www.ncbi.nlm.nih.gov/gene/?term=54974 "ICF45, IHG-1, hTHG1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015855 54974 THG1L http://www.ncbi.nlm.nih.gov/gene/?term=54974 "ICF45, IHG-1, hTHG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015856 54976 C20orf27 http://www.ncbi.nlm.nih.gov/gene/?term=54976 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015857 54977 SLC25A38 http://www.ncbi.nlm.nih.gov/gene/?term=54977 SIDBA2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015858 54977 SLC25A38 http://www.ncbi.nlm.nih.gov/gene/?term=54977 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015859 54978 SLC35F6 http://www.ncbi.nlm.nih.gov/gene/?term=54978 "ANT2BP, C2orf18, TANGO9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015860 54978 SLC35F6 http://www.ncbi.nlm.nih.gov/gene/?term=54978 "ANT2BP, C2orf18, TANGO9 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015861 54978 SLC35F6 http://www.ncbi.nlm.nih.gov/gene/?term=54978 "ANT2BP, C2orf18, TANGO9 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015862 54978 SLC35F6 http://www.ncbi.nlm.nih.gov/gene/?term=54978 "ANT2BP, C2orf18, TANGO9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015863 54982 CLN6 http://www.ncbi.nlm.nih.gov/gene/?term=54982 "CLN4A, HsT18960, nclf " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015864 54985 HCFC1R1 http://www.ncbi.nlm.nih.gov/gene/?term=54985 HPIP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015865 54985 HCFC1R1 http://www.ncbi.nlm.nih.gov/gene/?term=54985 HPIP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015866 54987 C1orf123 http://www.ncbi.nlm.nih.gov/gene/?term=54987 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015867 54987 C1orf123 http://www.ncbi.nlm.nih.gov/gene/?term=54987 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015868 54989 ZNF770 http://www.ncbi.nlm.nih.gov/gene/?term=54989 PRO1914 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015869 54989 ZNF770 http://www.ncbi.nlm.nih.gov/gene/?term=54989 PRO1914 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015870 5498 PPOX http://www.ncbi.nlm.nih.gov/gene/?term=5498 "PPO, V290M, VP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015871 54991 C1orf159 http://www.ncbi.nlm.nih.gov/gene/?term=54991 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015872 54993 ZSCAN2 http://www.ncbi.nlm.nih.gov/gene/?term=54993 "ZFP29, ZNF854 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015873 54993 ZSCAN2 http://www.ncbi.nlm.nih.gov/gene/?term=54993 "ZFP29, ZNF854 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015874 54994 GID8 http://www.ncbi.nlm.nih.gov/gene/?term=54994 "C20orf11, TWA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015875 54994 GID8 http://www.ncbi.nlm.nih.gov/gene/?term=54994 "C20orf11, TWA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015876 54995 OXSM http://www.ncbi.nlm.nih.gov/gene/?term=54995 "FASN2D, KASI, KS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015877 54995 OXSM http://www.ncbi.nlm.nih.gov/gene/?term=54995 "FASN2D, KASI, KS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015878 54997 TESC http://www.ncbi.nlm.nih.gov/gene/?term=54997 "CHP3, TSC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015879 54998 AURKAIP1 http://www.ncbi.nlm.nih.gov/gene/?term=54998 "AIP, AKIP, MRP-S38 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015880 5499 PPP1CA http://www.ncbi.nlm.nih.gov/gene/?term=5499 "PP-1A, PP1A, PP1alpha, PPP1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015881 5499 PPP1CA http://www.ncbi.nlm.nih.gov/gene/?term=5499 "PP-1A, PP1A, PP1alpha, PPP1A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015882 5499 PPP1CA http://www.ncbi.nlm.nih.gov/gene/?term=5499 "PP-1A, PP1A, PP1alpha, PPP1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015883 54 ACP5 http://www.ncbi.nlm.nih.gov/gene/?term=54 "HPAP, SPENCDI, TRAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015884 55000 TUG1 http://www.ncbi.nlm.nih.gov/gene/?term=55000 "LINC00080, NCRNA00080, TI-227H " lncRNA Homo sapiens 19571010 Nucleus HFF|HLF|HeLa cell Fluorescence in situ hybridization "Figure 3b: Subcellular localization analysis of lincRNAs by RNA FISH demonstrates localization of lincRNAs to the nucleus. Each panel represents the in situ hybridization of �0 fluorescently labeled DNA oligos with complementarity to the interrogated lincRNA. RNA FISH experiments were performed in male hFF for each represented lincRNA (XIST, HOTAIR, TUG-1, lincMKLN-1, lincFOXF1, and lincSFPQ), and also in female hLF for XIST (XX). White “speckles�indicate the subcellular localization of each lincRNA. The nuclear compartment is demarked by DAPI staining (purple). " RLID00015885 55000 TUG1 http://www.ncbi.nlm.nih.gov/gene/?term=55000 "LINC00080, NCRNA00080, TI-227H " lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015886 55000 TUG1 http://www.ncbi.nlm.nih.gov/gene/?term=55000 "LINC00080, NCRNA00080, TI-227H " lncRNA Homo sapiens 22078878 Nucleus HeLa cell|Kidney|Lung fibroblast In situ hybridizationq|RT-PCR "While Pc2 methylation appears to be the key determinant for relocation of growth control genes, based on a methylation/demethylation dependent switch in preference for TUG1 or NEAT2 interactions, respectively, we are tempted to speculate that other ncRNAs recognize covalent modifications of other gene-associated proteins, exerting their ncRNA scaffold functions in distinct subnuclear compartments to act as sensors for many regulated signaling pathways, and as modulators of 'reading' marks on histone tails for a variety of chromodomain-containing proteins and other histone code 'readers'. " RLID00015887 55000 TUG1 http://www.ncbi.nlm.nih.gov/gene/?term=55000 "LINC00080, NCRNA00080, TI-227H " lncRNA Homo sapiens 25630241 Nucleus Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00015888 55002 TMCO3 http://www.ncbi.nlm.nih.gov/gene/?term=55002 C13orf11 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015889 55003 PAK1IP1 http://www.ncbi.nlm.nih.gov/gene/?term=55003 "MAK11, PIP1, WDR84, bA421M1.5, hPIP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015890 55003 PAK1IP1 http://www.ncbi.nlm.nih.gov/gene/?term=55003 "MAK11, PIP1, WDR84, bA421M1.5, hPIP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015891 55004 LAMTOR1 http://www.ncbi.nlm.nih.gov/gene/?term=55004 "C11orf59, PDRO, Ragulator1, p18, p27RF-Rho " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015892 55006 TRMT61B http://www.ncbi.nlm.nih.gov/gene/?term=55006 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015893 55006 TRMT61B http://www.ncbi.nlm.nih.gov/gene/?term=55006 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015894 55007 FAM118A http://www.ncbi.nlm.nih.gov/gene/?term=55007 C22orf8 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015895 55008 HERC6 http://www.ncbi.nlm.nih.gov/gene/?term=55008 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015896 55009 C19orf24 http://www.ncbi.nlm.nih.gov/gene/?term=55009 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015897 5500 PPP1CB http://www.ncbi.nlm.nih.gov/gene/?term=5500 "HEL-S-80p, PP-1B, PP1B, PP1beta, PPP1CD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015898 5500 PPP1CB http://www.ncbi.nlm.nih.gov/gene/?term=5500 "HEL-S-80p, PP-1B, PP1B, PP1beta, PPP1CD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015899 55011 PIH1D1 http://www.ncbi.nlm.nih.gov/gene/?term=55011 NOP17 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015900 55011 PIH1D1 http://www.ncbi.nlm.nih.gov/gene/?term=55011 NOP17 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015901 55013 CCDC109B http://www.ncbi.nlm.nih.gov/gene/?term=55013 MCUb mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015902 55014 STX17 http://www.ncbi.nlm.nih.gov/gene/?term=55014 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015903 55017 C14orf119 http://www.ncbi.nlm.nih.gov/gene/?term=55017 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015904 55017 C14orf119 http://www.ncbi.nlm.nih.gov/gene/?term=55017 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015905 55017 C14orf119 http://www.ncbi.nlm.nih.gov/gene/?term=55017 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015906 55017 C14orf119 http://www.ncbi.nlm.nih.gov/gene/?term=55017 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015907 5501 PPP1CC http://www.ncbi.nlm.nih.gov/gene/?term=5501 "PP-1G, PP1C, PPP1G " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015908 5501 PPP1CC http://www.ncbi.nlm.nih.gov/gene/?term=5501 "PP-1G, PP1C, PPP1G " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015909 55020 TTC38 http://www.ncbi.nlm.nih.gov/gene/?term=55020 LL22NC03-5H6.5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015910 55020 TTC38 http://www.ncbi.nlm.nih.gov/gene/?term=55020 LL22NC03-5H6.5 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015911 55023 PHIP http://www.ncbi.nlm.nih.gov/gene/?term=55023 "BRWD2, DCAF14, WDR11, ndrp " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015912 55027 HEATR3 http://www.ncbi.nlm.nih.gov/gene/?term=55027 SYO1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015913 55031 USP47 http://www.ncbi.nlm.nih.gov/gene/?term=55031 TRFP mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015914 55031 USP47 http://www.ncbi.nlm.nih.gov/gene/?term=55031 TRFP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015915 55033 FKBP14 http://www.ncbi.nlm.nih.gov/gene/?term=55033 "EDSKMH, FKBP22, IPBP12 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015916 55034 MOCOS http://www.ncbi.nlm.nih.gov/gene/?term=55034 "HMCS, MCS, MOS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015917 55035 NOL8 http://www.ncbi.nlm.nih.gov/gene/?term=55035 "C9orf34, NOP132, bA62C3.3, bA62C3.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015918 55037 PTCD3 http://www.ncbi.nlm.nih.gov/gene/?term=55037 MRP-S39 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015919 55037 PTCD3 http://www.ncbi.nlm.nih.gov/gene/?term=55037 MRP-S39 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015920 55039 TRMT12 http://www.ncbi.nlm.nih.gov/gene/?term=55039 "TRM12, TYW2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015921 55041 PLEKHB2 http://www.ncbi.nlm.nih.gov/gene/?term=55041 EVT2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015922 55041 PLEKHB2 http://www.ncbi.nlm.nih.gov/gene/?term=55041 EVT2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015923 55041 PLEKHB2 http://www.ncbi.nlm.nih.gov/gene/?term=55041 EVT2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015924 55041 PLEKHB2 http://www.ncbi.nlm.nih.gov/gene/?term=55041 EVT2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015925 55048 VPS37C http://www.ncbi.nlm.nih.gov/gene/?term=55048 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015926 55048 VPS37C http://www.ncbi.nlm.nih.gov/gene/?term=55048 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015927 55049 C19orf60 http://www.ncbi.nlm.nih.gov/gene/?term=55049 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015928 5504 PPP1R2 http://www.ncbi.nlm.nih.gov/gene/?term=5504 "IPP-2, IPP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015929 5504 PPP1R2 http://www.ncbi.nlm.nih.gov/gene/?term=5504 "IPP-2, IPP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015930 55052 MRPL20 http://www.ncbi.nlm.nih.gov/gene/?term=55052 "L20mt, MRP-L20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015931 55054 ATG16L1 http://www.ncbi.nlm.nih.gov/gene/?term=55054 "APG16L, ATG16A, ATG16L, IBD10, WDR30 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015932 55055 ZWILCH http://www.ncbi.nlm.nih.gov/gene/?term=55055 "KNTC1AP, hZwilch " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015933 55055 ZWILCH http://www.ncbi.nlm.nih.gov/gene/?term=55055 "KNTC1AP, hZwilch " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015934 550619 Arid3c http://www.ncbi.nlm.nih.gov/gene/?term=550619 OTTMUSG00000006683 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00015935 55062 WIPI1 http://www.ncbi.nlm.nih.gov/gene/?term=55062 "ATG18, ATG18A, WIPI49 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015936 55062 WIPI1 http://www.ncbi.nlm.nih.gov/gene/?term=55062 "ATG18, ATG18A, WIPI49 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015937 55062 WIPI1 http://www.ncbi.nlm.nih.gov/gene/?term=55062 "ATG18, ATG18A, WIPI49 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015938 550643 LINC01420 http://www.ncbi.nlm.nih.gov/gene/?term=550643 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015939 55065 SLC52A1 http://www.ncbi.nlm.nih.gov/gene/?term=55065 "GPCR42, GPR172B, PAR2, RBFVD, RFT1, RFVT1, hRFT1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015940 55065 SLC52A1 http://www.ncbi.nlm.nih.gov/gene/?term=55065 "GPCR42, GPR172B, PAR2, RBFVD, RFT1, RFVT1, hRFT1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015941 55066 PDPR http://www.ncbi.nlm.nih.gov/gene/?term=55066 PDP3 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015942 55066 PDPR http://www.ncbi.nlm.nih.gov/gene/?term=55066 PDP3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015943 55066 PDPR http://www.ncbi.nlm.nih.gov/gene/?term=55066 PDP3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015944 55069 TMEM248 http://www.ncbi.nlm.nih.gov/gene/?term=55069 C7orf42 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015945 55069 TMEM248 http://www.ncbi.nlm.nih.gov/gene/?term=55069 C7orf42 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015946 55069 TMEM248 http://www.ncbi.nlm.nih.gov/gene/?term=55069 C7orf42 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015947 55070 DET1 http://www.ncbi.nlm.nih.gov/gene/?term=55070 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015948 55071 C9orf40 http://www.ncbi.nlm.nih.gov/gene/?term=55071 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015949 55072 RNF31 http://www.ncbi.nlm.nih.gov/gene/?term=55072 "HOIP, ZIBRA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015950 55072 RNF31 http://www.ncbi.nlm.nih.gov/gene/?term=55072 "HOIP, ZIBRA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015951 55075 UACA http://www.ncbi.nlm.nih.gov/gene/?term=55075 NUCLING mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015952 55076 TMEM45A http://www.ncbi.nlm.nih.gov/gene/?term=55076 DERP7 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015953 55082 ARGLU1 http://www.ncbi.nlm.nih.gov/gene/?term=55082 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015954 55088 CCDC186 http://www.ncbi.nlm.nih.gov/gene/?term=55088 C10orf118 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015955 55088 CCDC186 http://www.ncbi.nlm.nih.gov/gene/?term=55088 C10orf118 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015956 55088 CCDC186 http://www.ncbi.nlm.nih.gov/gene/?term=55088 C10orf118 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015957 55090 MED9 http://www.ncbi.nlm.nih.gov/gene/?term=55090 MED25 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015958 55090 MED9 http://www.ncbi.nlm.nih.gov/gene/?term=55090 MED25 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015959 55093 WDYHV1 http://www.ncbi.nlm.nih.gov/gene/?term=55093 C8orf32 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015960 55094 GPATCH1 http://www.ncbi.nlm.nih.gov/gene/?term=55094 "ECGP, GPATC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015961 55095 SAMD4B http://www.ncbi.nlm.nih.gov/gene/?term=55095 "SMGB, Smaug2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015962 55095 SAMD4B http://www.ncbi.nlm.nih.gov/gene/?term=55095 "SMGB, Smaug2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015963 550 AUP1 http://www.ncbi.nlm.nih.gov/gene/?term=550 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015964 550 AUP1 http://www.ncbi.nlm.nih.gov/gene/?term=550 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015965 55101 ATP5SL http://www.ncbi.nlm.nih.gov/gene/?term=55101 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015966 55102 ATG2B http://www.ncbi.nlm.nih.gov/gene/?term=55102 C14orf103 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015967 55103 RALGPS2 http://www.ncbi.nlm.nih.gov/gene/?term=55103 dJ595C2.1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015968 55107 ANO1 http://www.ncbi.nlm.nih.gov/gene/?term=55107 "DOG1, ORAOV2, TAOS2, TMEM16A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015969 55108 BSDC1 http://www.ncbi.nlm.nih.gov/gene/?term=55108 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015970 55109 AGGF1 http://www.ncbi.nlm.nih.gov/gene/?term=55109 "GPATC7, GPATCH7, HSU84971, HUS84971, VG5Q " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015971 55109 AGGF1 http://www.ncbi.nlm.nih.gov/gene/?term=55109 "GPATC7, GPATCH7, HSU84971, HUS84971, VG5Q " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015972 5510 PPP1R7 http://www.ncbi.nlm.nih.gov/gene/?term=5510 SDS22 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015973 5510 PPP1R7 http://www.ncbi.nlm.nih.gov/gene/?term=5510 SDS22 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015974 5510 PPP1R7 http://www.ncbi.nlm.nih.gov/gene/?term=5510 SDS22 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015975 55110 MAGOHB http://www.ncbi.nlm.nih.gov/gene/?term=55110 "MGN2, mago, magoh " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015976 55111 PLEKHJ1 http://www.ncbi.nlm.nih.gov/gene/?term=55111 GNRPX mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015977 55113 XKR8 http://www.ncbi.nlm.nih.gov/gene/?term=55113 "XRG8, hXkr8 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015978 55114 ARHGAP17 http://www.ncbi.nlm.nih.gov/gene/?term=55114 "MST066, MST110, MSTP038, MSTP066, MSTP110, NADRIN, PP367, PP4534, RICH-1, RICH1, WBP15 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015979 55114 ARHGAP17 http://www.ncbi.nlm.nih.gov/gene/?term=55114 "MST066, MST110, MSTP038, MSTP066, MSTP110, NADRIN, PP367, PP4534, RICH-1, RICH1, WBP15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015980 55117 SLC6A15 http://www.ncbi.nlm.nih.gov/gene/?term=55117 "NTT73, SBAT1, V7-3, hv7-3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015981 55117 SLC6A15 http://www.ncbi.nlm.nih.gov/gene/?term=55117 "NTT73, SBAT1, V7-3, hv7-3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015982 55119 PRPF38B http://www.ncbi.nlm.nih.gov/gene/?term=55119 NET1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015983 55119 PRPF38B http://www.ncbi.nlm.nih.gov/gene/?term=55119 NET1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015984 5511 PPP1R8 http://www.ncbi.nlm.nih.gov/gene/?term=5511 "ARD-1, ARD1, NIPP-1, NIPP1, PRO2047 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015985 5511 PPP1R8 http://www.ncbi.nlm.nih.gov/gene/?term=5511 "ARD-1, ARD1, NIPP-1, NIPP1, PRO2047 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015986 5511 PPP1R8 http://www.ncbi.nlm.nih.gov/gene/?term=5511 "ARD-1, ARD1, NIPP-1, NIPP1, PRO2047 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015987 55120 FANCL http://www.ncbi.nlm.nih.gov/gene/?term=55120 "FAAP43, PHF9, POG " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015988 55122 AKIRIN2 http://www.ncbi.nlm.nih.gov/gene/?term=55122 "C6orf166, FBI1, dJ486L4.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015989 55125 CEP192 http://www.ncbi.nlm.nih.gov/gene/?term=55125 PPP1R62 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015990 55125 CEP192 http://www.ncbi.nlm.nih.gov/gene/?term=55125 PPP1R62 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015991 55127 HEATR1 http://www.ncbi.nlm.nih.gov/gene/?term=55127 "BAP28, UTP10 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015992 55128 TRIM68 http://www.ncbi.nlm.nih.gov/gene/?term=55128 "GC109, RNF137, SS-56, SS56 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015993 55128 TRIM68 http://www.ncbi.nlm.nih.gov/gene/?term=55128 "GC109, RNF137, SS-56, SS56 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015994 55131 RBM28 http://www.ncbi.nlm.nih.gov/gene/?term=55131 ANES mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00015995 55132 LARP1B http://www.ncbi.nlm.nih.gov/gene/?term=55132 LARP2 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015996 55135 WRAP53 http://www.ncbi.nlm.nih.gov/gene/?term=55135 "DKCB3, TCAB1, WDR79 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00015997 55140 ELP3 http://www.ncbi.nlm.nih.gov/gene/?term=55140 KAT9 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00015998 55140 ELP3 http://www.ncbi.nlm.nih.gov/gene/?term=55140 KAT9 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00015999 55140 ELP3 http://www.ncbi.nlm.nih.gov/gene/?term=55140 KAT9 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016000 55140 ELP3 http://www.ncbi.nlm.nih.gov/gene/?term=55140 KAT9 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016001 55142 HAUS2 http://www.ncbi.nlm.nih.gov/gene/?term=55142 "C15orf25, CEP27, HsT17025 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016002 55143 CDCA8 http://www.ncbi.nlm.nih.gov/gene/?term=55143 "BOR, BOREALIN, DasraB, MESRGP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016003 55143 CDCA8 http://www.ncbi.nlm.nih.gov/gene/?term=55143 "BOR, BOREALIN, DasraB, MESRGP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016004 55143 CDCA8 http://www.ncbi.nlm.nih.gov/gene/?term=55143 "BOR, BOREALIN, DasraB, MESRGP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016005 55146 ZDHHC4 http://www.ncbi.nlm.nih.gov/gene/?term=55146 ZNF374 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016006 55146 ZDHHC4 http://www.ncbi.nlm.nih.gov/gene/?term=55146 ZNF374 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016007 55147 RBM23 http://www.ncbi.nlm.nih.gov/gene/?term=55147 "CAPERbeta, PP239, RNPC4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016008 55148 UBR7 http://www.ncbi.nlm.nih.gov/gene/?term=55148 C14orf130 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016009 55148 UBR7 http://www.ncbi.nlm.nih.gov/gene/?term=55148 C14orf130 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016010 55149 MTPAP http://www.ncbi.nlm.nih.gov/gene/?term=55149 "PAPD1, SPAX4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016011 55149 MTPAP http://www.ncbi.nlm.nih.gov/gene/?term=55149 "PAPD1, SPAX4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016012 55149 MTPAP http://www.ncbi.nlm.nih.gov/gene/?term=55149 "PAPD1, SPAX4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016013 5514 PPP1R10 http://www.ncbi.nlm.nih.gov/gene/?term=5514 "CAT53, FB19, PNUTS, PP1R10, R111, p99 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016014 5514 PPP1R10 http://www.ncbi.nlm.nih.gov/gene/?term=5514 "CAT53, FB19, PNUTS, PP1R10, R111, p99 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016015 55151 TMEM38B http://www.ncbi.nlm.nih.gov/gene/?term=55151 "C9orf87, D4Ertd89e, OI14, TRIC-B, TRICB, bA219P18.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016016 55151 TMEM38B http://www.ncbi.nlm.nih.gov/gene/?term=55151 "C9orf87, D4Ertd89e, OI14, TRIC-B, TRICB, bA219P18.1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016017 55154 MSTO1 http://www.ncbi.nlm.nih.gov/gene/?term=55154 "LST005, MST " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016018 55154 MSTO1 http://www.ncbi.nlm.nih.gov/gene/?term=55154 "LST005, MST " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016019 55156 ARMC1 http://www.ncbi.nlm.nih.gov/gene/?term=55156 Arcp mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016020 55156 ARMC1 http://www.ncbi.nlm.nih.gov/gene/?term=55156 Arcp mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016021 5515 PPP2CA http://www.ncbi.nlm.nih.gov/gene/?term=5515 "PP2Ac, PP2CA, PP2Calpha, RP-C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016022 5515 PPP2CA http://www.ncbi.nlm.nih.gov/gene/?term=5515 "PP2Ac, PP2CA, PP2Calpha, RP-C " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016023 5515 PPP2CA http://www.ncbi.nlm.nih.gov/gene/?term=5515 "PP2Ac, PP2CA, PP2Calpha, RP-C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016024 55161 TMEM33 http://www.ncbi.nlm.nih.gov/gene/?term=55161 "1600019D15Rik, SHINC3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016025 55163 PNPO http://www.ncbi.nlm.nih.gov/gene/?term=55163 "HEL-S-302, PDXPO " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016026 55163 PNPO http://www.ncbi.nlm.nih.gov/gene/?term=55163 "HEL-S-302, PDXPO " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016027 55163 PNPO http://www.ncbi.nlm.nih.gov/gene/?term=55163 "HEL-S-302, PDXPO " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016028 55163 PNPO http://www.ncbi.nlm.nih.gov/gene/?term=55163 "HEL-S-302, PDXPO " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016029 55164 SHQ1 http://www.ncbi.nlm.nih.gov/gene/?term=55164 "GRIM-1, Shq1p " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016030 55164 SHQ1 http://www.ncbi.nlm.nih.gov/gene/?term=55164 "GRIM-1, Shq1p " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016031 55165 CEP55 http://www.ncbi.nlm.nih.gov/gene/?term=55165 "C10orf3, CT111, URCC6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016032 55165 CEP55 http://www.ncbi.nlm.nih.gov/gene/?term=55165 "C10orf3, CT111, URCC6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016033 55166 CENPQ http://www.ncbi.nlm.nih.gov/gene/?term=55166 "C6orf139, CENP-Q " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016034 55168 MRPS18A http://www.ncbi.nlm.nih.gov/gene/?term=55168 "HumanS18b, MRP-S18-3, MRPS18-3, S18bmt " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016035 5516 PPP2CB http://www.ncbi.nlm.nih.gov/gene/?term=5516 "PP2Abeta, PP2CB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016036 5516 PPP2CB http://www.ncbi.nlm.nih.gov/gene/?term=5516 "PP2Abeta, PP2CB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016037 5516 PPP2CB http://www.ncbi.nlm.nih.gov/gene/?term=5516 "PP2Abeta, PP2CB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016038 55170 PRMT6 http://www.ncbi.nlm.nih.gov/gene/?term=55170 HRMT1L6 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016039 55170 PRMT6 http://www.ncbi.nlm.nih.gov/gene/?term=55170 HRMT1L6 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016040 55171 TBCCD1 http://www.ncbi.nlm.nih.gov/gene/?term=55171 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016041 55171 TBCCD1 http://www.ncbi.nlm.nih.gov/gene/?term=55171 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016042 55172 DNAAF2 http://www.ncbi.nlm.nih.gov/gene/?term=55172 "C14orf104, CILD10, KTU, PF13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016043 55172 DNAAF2 http://www.ncbi.nlm.nih.gov/gene/?term=55172 "C14orf104, CILD10, KTU, PF13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016044 55173 MRPS10 http://www.ncbi.nlm.nih.gov/gene/?term=55173 "MRP-S10, PNAS-122 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016045 55173 MRPS10 http://www.ncbi.nlm.nih.gov/gene/?term=55173 "MRP-S10, PNAS-122 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016046 55174 INTS10 http://www.ncbi.nlm.nih.gov/gene/?term=55174 "C8orf35, INT10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016047 55175 KLHL11 http://www.ncbi.nlm.nih.gov/gene/?term=55175 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016048 55176 SEC61A2 http://www.ncbi.nlm.nih.gov/gene/?term=55176 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016049 55176 SEC61A2 http://www.ncbi.nlm.nih.gov/gene/?term=55176 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016050 55177 RMDN3 http://www.ncbi.nlm.nih.gov/gene/?term=55177 "FAM82A2, FAM82C, RMD-3, RMD3, ptpip51 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016051 55178 RNMTL1 http://www.ncbi.nlm.nih.gov/gene/?term=55178 "MRM3, RMTL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016052 55179 FAIM http://www.ncbi.nlm.nih.gov/gene/?term=55179 FAIM1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016053 55179 FAIM http://www.ncbi.nlm.nih.gov/gene/?term=55179 FAIM1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016054 55179 FAIM http://www.ncbi.nlm.nih.gov/gene/?term=55179 FAIM1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016055 55180 LINS1 http://www.ncbi.nlm.nih.gov/gene/?term=55180 "LINS, MRT27, WINS1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016056 55182 RNF220 http://www.ncbi.nlm.nih.gov/gene/?term=55182 C1orf164 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016057 55183 RIF1 http://www.ncbi.nlm.nih.gov/gene/?term=55183 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016058 55186 SLC25A36 http://www.ncbi.nlm.nih.gov/gene/?term=55186 PNC2 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016059 55186 SLC25A36 http://www.ncbi.nlm.nih.gov/gene/?term=55186 PNC2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016060 55187 VPS13D http://www.ncbi.nlm.nih.gov/gene/?term=55187 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016061 55187 VPS13D http://www.ncbi.nlm.nih.gov/gene/?term=55187 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016062 5518 PPP2R1A http://www.ncbi.nlm.nih.gov/gene/?term=5518 "MRD36, PP2A-Aalpha, PP2AAALPHA, PR65A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016063 5518 PPP2R1A http://www.ncbi.nlm.nih.gov/gene/?term=5518 "MRD36, PP2A-Aalpha, PP2AAALPHA, PR65A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016064 55191 NADSYN1 http://www.ncbi.nlm.nih.gov/gene/?term=55191 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016065 55193 PBRM1 http://www.ncbi.nlm.nih.gov/gene/?term=55193 "BAF180, PB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016066 55196 KIAA1551 http://www.ncbi.nlm.nih.gov/gene/?term=55196 "C12orf35, UTA2-1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016067 55197 RPRD1A http://www.ncbi.nlm.nih.gov/gene/?term=55197 "HsT3101, P15RS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016068 55198 APPL2 http://www.ncbi.nlm.nih.gov/gene/?term=55198 DIP13B mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016069 55198 APPL2 http://www.ncbi.nlm.nih.gov/gene/?term=55198 DIP13B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016070 55199 FAM86C1 http://www.ncbi.nlm.nih.gov/gene/?term=55199 FAM86C mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016071 5519 PPP2R1B http://www.ncbi.nlm.nih.gov/gene/?term=5519 "PP2A-Abeta, PR65B " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016072 5519 PPP2R1B http://www.ncbi.nlm.nih.gov/gene/?term=5519 "PP2A-Abeta, PR65B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016073 55201 MAP1S http://www.ncbi.nlm.nih.gov/gene/?term=55201 "BPY2IP1, C19orf5, MAP8, VCY2IP-1, VCY2IP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016074 55205 ZNF532 http://www.ncbi.nlm.nih.gov/gene/?term=55205 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016075 55206 SBNO1 http://www.ncbi.nlm.nih.gov/gene/?term=55206 "MOP3, Sno " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016076 55206 SBNO1 http://www.ncbi.nlm.nih.gov/gene/?term=55206 "MOP3, Sno " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016077 55206 SBNO1 http://www.ncbi.nlm.nih.gov/gene/?term=55206 "MOP3, Sno " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016078 55206 SBNO1 http://www.ncbi.nlm.nih.gov/gene/?term=55206 "MOP3, Sno " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016079 55207 ARL8B http://www.ncbi.nlm.nih.gov/gene/?term=55207 "ARL10C, Gie1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016080 55207 ARL8B http://www.ncbi.nlm.nih.gov/gene/?term=55207 "ARL10C, Gie1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016081 55207 ARL8B http://www.ncbi.nlm.nih.gov/gene/?term=55207 "ARL10C, Gie1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016082 55209 SETD5 http://www.ncbi.nlm.nih.gov/gene/?term=55209 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016083 55209 SETD5 http://www.ncbi.nlm.nih.gov/gene/?term=55209 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016084 5520 PPP2R2A http://www.ncbi.nlm.nih.gov/gene/?term=5520 "B55A, B55ALPHA, PR52A, PR55A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016085 55210 ATAD3A http://www.ncbi.nlm.nih.gov/gene/?term=55210 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016086 55210 ATAD3A http://www.ncbi.nlm.nih.gov/gene/?term=55210 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016087 55211 DPPA4 http://www.ncbi.nlm.nih.gov/gene/?term=55211 2410091M23Rik mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016088 55211 DPPA4 http://www.ncbi.nlm.nih.gov/gene/?term=55211 2410091M23Rik mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016089 55212 BBS7 http://www.ncbi.nlm.nih.gov/gene/?term=55212 BBS2L1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016090 55212 BBS7 http://www.ncbi.nlm.nih.gov/gene/?term=55212 BBS2L1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016091 55213 RCBTB1 http://www.ncbi.nlm.nih.gov/gene/?term=55213 "CLLD7, CLLL7, GLP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016092 55213 RCBTB1 http://www.ncbi.nlm.nih.gov/gene/?term=55213 "CLLD7, CLLL7, GLP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016093 55213 RCBTB1 http://www.ncbi.nlm.nih.gov/gene/?term=55213 "CLLD7, CLLL7, GLP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016094 55215 FANCI http://www.ncbi.nlm.nih.gov/gene/?term=55215 KIAA1794 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016095 55215 FANCI http://www.ncbi.nlm.nih.gov/gene/?term=55215 KIAA1794 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016096 55216 C11orf57 http://www.ncbi.nlm.nih.gov/gene/?term=55216 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016097 55217 TMLHE http://www.ncbi.nlm.nih.gov/gene/?term=55217 "AUTSX6, BBOX2, TMLD, TMLH, TMLHED, XAP130 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016098 55218 EXD2 http://www.ncbi.nlm.nih.gov/gene/?term=55218 "C14orf114, EXDL2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016099 55219 TMEM57 http://www.ncbi.nlm.nih.gov/gene/?term=55219 MACOILIN mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016100 55219 TMEM57 http://www.ncbi.nlm.nih.gov/gene/?term=55219 MACOILIN mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016101 55220 KLHDC8A http://www.ncbi.nlm.nih.gov/gene/?term=55220 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016102 55222 LRRC20 http://www.ncbi.nlm.nih.gov/gene/?term=55222 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016103 55225 RAVER2 http://www.ncbi.nlm.nih.gov/gene/?term=55225 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016104 55227 LRRC1 http://www.ncbi.nlm.nih.gov/gene/?term=55227 "LANO, dJ523E19.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016105 55227 LRRC1 http://www.ncbi.nlm.nih.gov/gene/?term=55227 "LANO, dJ523E19.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016106 55230 USP40 http://www.ncbi.nlm.nih.gov/gene/?term=55230 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016107 55230 USP40 http://www.ncbi.nlm.nih.gov/gene/?term=55230 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016108 55233 MOB1A http://www.ncbi.nlm.nih.gov/gene/?term=55233 "C2orf6, MATS1, MOB1, MOBK1B, MOBKL1B, Mob4B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016109 55234 SMU1 http://www.ncbi.nlm.nih.gov/gene/?term=55234 "BWD, SMU-1, fSAP57 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016110 55234 SMU1 http://www.ncbi.nlm.nih.gov/gene/?term=55234 "BWD, SMU-1, fSAP57 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016111 55234 SMU1 http://www.ncbi.nlm.nih.gov/gene/?term=55234 "BWD, SMU-1, fSAP57 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016112 55234 SMU1 http://www.ncbi.nlm.nih.gov/gene/?term=55234 "BWD, SMU-1, fSAP57 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016113 55236 UBA6 http://www.ncbi.nlm.nih.gov/gene/?term=55236 "E1-L2, MOP-4, UBE1L2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016114 55236 UBA6 http://www.ncbi.nlm.nih.gov/gene/?term=55236 "E1-L2, MOP-4, UBE1L2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016115 55236 UBA6 http://www.ncbi.nlm.nih.gov/gene/?term=55236 "E1-L2, MOP-4, UBE1L2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016116 55238 SLC38A7 http://www.ncbi.nlm.nih.gov/gene/?term=55238 SNAT7 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016117 55239 OGFOD1 http://www.ncbi.nlm.nih.gov/gene/?term=55239 TPA1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016118 55239 OGFOD1 http://www.ncbi.nlm.nih.gov/gene/?term=55239 TPA1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016119 55239 OGFOD1 http://www.ncbi.nlm.nih.gov/gene/?term=55239 TPA1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016120 55240 STEAP3 http://www.ncbi.nlm.nih.gov/gene/?term=55240 "AHMIO2, STMP3, TSAP6, dudlin-2, dudulin-2, pHyde " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016121 55244 SLC47A1 http://www.ncbi.nlm.nih.gov/gene/?term=55244 MATE1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016122 55245 UQCC1 http://www.ncbi.nlm.nih.gov/gene/?term=55245 "BFZB, C20orf44, CBP3, UQCC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016123 55246 CCDC25 http://www.ncbi.nlm.nih.gov/gene/?term=55246 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016124 55248 TMEM206 http://www.ncbi.nlm.nih.gov/gene/?term=55248 C1orf75 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016125 55248 TMEM206 http://www.ncbi.nlm.nih.gov/gene/?term=55248 C1orf75 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016126 55249 YY1AP1 http://www.ncbi.nlm.nih.gov/gene/?term=55249 "HCCA1, HCCA2, YAP, YY1AP " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016127 55249 YY1AP1 http://www.ncbi.nlm.nih.gov/gene/?term=55249 "HCCA1, HCCA2, YAP, YY1AP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016128 5524 PPP2R4 http://www.ncbi.nlm.nih.gov/gene/?term=5524 "PP2A, PR53, PTPA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016129 55250 ELP2 http://www.ncbi.nlm.nih.gov/gene/?term=55250 "SHINC-2, STATIP1, StIP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016130 55250 ELP2 http://www.ncbi.nlm.nih.gov/gene/?term=55250 "SHINC-2, STATIP1, StIP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016131 55250 ELP2 http://www.ncbi.nlm.nih.gov/gene/?term=55250 "SHINC-2, STATIP1, StIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016132 55251 PCMTD2 http://www.ncbi.nlm.nih.gov/gene/?term=55251 C20orf36 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016133 55252 ASXL2 http://www.ncbi.nlm.nih.gov/gene/?term=55252 ASXH2 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016134 55252 ASXL2 http://www.ncbi.nlm.nih.gov/gene/?term=55252 ASXH2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016135 55253 TYW1 http://www.ncbi.nlm.nih.gov/gene/?term=55253 "RSAFD1, TYW1A, YPL207W " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016136 55254 TMEM39A http://www.ncbi.nlm.nih.gov/gene/?term=55254 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016137 55254 TMEM39A http://www.ncbi.nlm.nih.gov/gene/?term=55254 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016138 55255 WDR41 http://www.ncbi.nlm.nih.gov/gene/?term=55255 MSTP048 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016139 55256 ADI1 http://www.ncbi.nlm.nih.gov/gene/?term=55256 "APL1, ARD, Fe-ARD, HMFT1638, MTCBP1, Ni-ARD, SIPL, mtnD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016140 55256 ADI1 http://www.ncbi.nlm.nih.gov/gene/?term=55256 "APL1, ARD, Fe-ARD, HMFT1638, MTCBP1, Ni-ARD, SIPL, mtnD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016141 55256 ADI1 http://www.ncbi.nlm.nih.gov/gene/?term=55256 "APL1, ARD, Fe-ARD, HMFT1638, MTCBP1, Ni-ARD, SIPL, mtnD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016142 55257 MRGBP http://www.ncbi.nlm.nih.gov/gene/?term=55257 "C20orf20, Eaf7, MRG15BP, URCC4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016143 5525 PPP2R5A http://www.ncbi.nlm.nih.gov/gene/?term=5525 "B56A, PR61A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016144 5525 PPP2R5A http://www.ncbi.nlm.nih.gov/gene/?term=5525 "B56A, PR61A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016145 55260 TMEM143 http://www.ncbi.nlm.nih.gov/gene/?term=55260 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016146 55266 TMEM19 http://www.ncbi.nlm.nih.gov/gene/?term=55266 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016147 55269 PSPC1 http://www.ncbi.nlm.nih.gov/gene/?term=55269 PSP1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016148 55269 PSPC1 http://www.ncbi.nlm.nih.gov/gene/?term=55269 PSP1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016149 55269 PSPC1 http://www.ncbi.nlm.nih.gov/gene/?term=55269 PSP1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016150 5526 PPP2R5B http://www.ncbi.nlm.nih.gov/gene/?term=5526 "B56B, PR61B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016151 5526 PPP2R5B http://www.ncbi.nlm.nih.gov/gene/?term=5526 "B56B, PR61B " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016152 55270 NUDT15 http://www.ncbi.nlm.nih.gov/gene/?term=55270 MTH2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016153 55270 NUDT15 http://www.ncbi.nlm.nih.gov/gene/?term=55270 MTH2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016154 55272 IMP3 http://www.ncbi.nlm.nih.gov/gene/?term=55272 "BRMS2, C15orf12, MRPS4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016155 55272 IMP3 http://www.ncbi.nlm.nih.gov/gene/?term=55272 "BRMS2, C15orf12, MRPS4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016156 55274 PHF10 http://www.ncbi.nlm.nih.gov/gene/?term=55274 "BAF45A, XAP135 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016157 55275 VPS53 http://www.ncbi.nlm.nih.gov/gene/?term=55275 "HCCS1, PCH2E, hVps53L, pp13624 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016158 55275 VPS53 http://www.ncbi.nlm.nih.gov/gene/?term=55275 "HCCS1, PCH2E, hVps53L, pp13624 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016159 55276 PGM2 http://www.ncbi.nlm.nih.gov/gene/?term=55276 MSTP006 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016160 55276 PGM2 http://www.ncbi.nlm.nih.gov/gene/?term=55276 MSTP006 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016161 55276 PGM2 http://www.ncbi.nlm.nih.gov/gene/?term=55276 MSTP006 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016162 55277 FGGY http://www.ncbi.nlm.nih.gov/gene/?term=55277 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016163 55278 QRSL1 http://www.ncbi.nlm.nih.gov/gene/?term=55278 GatA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016164 5527 PPP2R5C http://www.ncbi.nlm.nih.gov/gene/?term=5527 "B56G, PR61G " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016165 5527 PPP2R5C http://www.ncbi.nlm.nih.gov/gene/?term=5527 "B56G, PR61G " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016166 55280 CWF19L1 http://www.ncbi.nlm.nih.gov/gene/?term=55280 "C19L1, SCAR17 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016167 55284 UBE2W http://www.ncbi.nlm.nih.gov/gene/?term=55284 "UBC-16, UBC16 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016168 55286 C4orf19 http://www.ncbi.nlm.nih.gov/gene/?term=55286 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016169 552889 ATXN7L3B http://www.ncbi.nlm.nih.gov/gene/?term=552889 lnc-SCA7 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016170 55288 RHOT1 http://www.ncbi.nlm.nih.gov/gene/?term=55288 "ARHT1, MIRO-1, MIRO1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016171 5528 PPP2R5D http://www.ncbi.nlm.nih.gov/gene/?term=5528 "B56D, MRD35 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016172 552900 BOLA2 http://www.ncbi.nlm.nih.gov/gene/?term=552900 "BOLA2A, My016 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016173 552902 LOC552902 http://www.ncbi.nlm.nih.gov/gene/?term=552902 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016174 55290 BRF2 http://www.ncbi.nlm.nih.gov/gene/?term=55290 "BRFU, TFIIIB50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016175 55291 PPP6R3 http://www.ncbi.nlm.nih.gov/gene/?term=55291 "C11orf23, PP6R3, SAP190, SAPL, SAPLa, SAPS3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016176 55291 PPP6R3 http://www.ncbi.nlm.nih.gov/gene/?term=55291 "C11orf23, PP6R3, SAP190, SAPL, SAPLa, SAPS3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016177 55293 UEVLD http://www.ncbi.nlm.nih.gov/gene/?term=55293 "ATTP, UEV3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016178 55294 FBXW7 http://www.ncbi.nlm.nih.gov/gene/?term=55294 "AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016179 55296 TBC1D19 http://www.ncbi.nlm.nih.gov/gene/?term=55296 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016180 55297 CCDC91 http://www.ncbi.nlm.nih.gov/gene/?term=55297 "HSD8, p56 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016181 55299 BRIX1 http://www.ncbi.nlm.nih.gov/gene/?term=55299 "BRIX, BXDC2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016182 55299 BRIX1 http://www.ncbi.nlm.nih.gov/gene/?term=55299 "BRIX, BXDC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016183 5529 PPP2R5E http://www.ncbi.nlm.nih.gov/gene/?term=5529 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016184 5529 PPP2R5E http://www.ncbi.nlm.nih.gov/gene/?term=5529 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016185 55300 PI4K2B http://www.ncbi.nlm.nih.gov/gene/?term=55300 "PI4KIIB, PIK42B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016186 55308 DDX19A http://www.ncbi.nlm.nih.gov/gene/?term=55308 "DDX19-DDX19L, DDX19L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016187 5530 PPP3CA http://www.ncbi.nlm.nih.gov/gene/?term=5530 "CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016188 5530 PPP3CA http://www.ncbi.nlm.nih.gov/gene/?term=5530 "CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016189 553115 PEF1 http://www.ncbi.nlm.nih.gov/gene/?term=553115 "ABP32A, PEF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016190 553115 PEF1 http://www.ncbi.nlm.nih.gov/gene/?term=553115 "ABP32A, PEF1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016191 553115 PEF1 http://www.ncbi.nlm.nih.gov/gene/?term=553115 "ABP32, PEF1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016192 55311 ZNF444 http://www.ncbi.nlm.nih.gov/gene/?term=55311 "EZF-2, EZF2, ZSCAN17 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016193 55312 RFK http://www.ncbi.nlm.nih.gov/gene/?term=55312 RIFK mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016194 55312 RFK http://www.ncbi.nlm.nih.gov/gene/?term=55312 RIFK mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016195 55312 RFK http://www.ncbi.nlm.nih.gov/gene/?term=55312 RIFK mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016196 55313 CPPED1 http://www.ncbi.nlm.nih.gov/gene/?term=55313 CSTP1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016197 55313 CPPED1 http://www.ncbi.nlm.nih.gov/gene/?term=55313 CSTP1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016198 55313 CPPED1 http://www.ncbi.nlm.nih.gov/gene/?term=55313 CSTP1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016199 55314 TMEM144 http://www.ncbi.nlm.nih.gov/gene/?term=55314 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016200 55316 RSAD1 http://www.ncbi.nlm.nih.gov/gene/?term=55316 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016201 55316 RSAD1 http://www.ncbi.nlm.nih.gov/gene/?term=55316 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016202 55317 AP5S1 http://www.ncbi.nlm.nih.gov/gene/?term=55317 C20orf29 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016203 55319 TMA16 http://www.ncbi.nlm.nih.gov/gene/?term=55319 C4orf43 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016204 55319 TMA16 http://www.ncbi.nlm.nih.gov/gene/?term=55319 C4orf43 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016205 5531 PPP4C http://www.ncbi.nlm.nih.gov/gene/?term=5531 "PP-X, PP4, PP4C, PPH3, PPP4, PPX " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016206 5531 PPP4C http://www.ncbi.nlm.nih.gov/gene/?term=5531 "PP-X, PP4, PP4C, PPH3, PPP4, PPX " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016207 5531 PPP4C http://www.ncbi.nlm.nih.gov/gene/?term=5531 "PP-X, PP4, PP4C, PPH3, PPP4, PPX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016208 55320 MIS18BP1 http://www.ncbi.nlm.nih.gov/gene/?term=55320 "C14orf106, HSA242977, KNL2, M18BP1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016209 55322 C5orf22 http://www.ncbi.nlm.nih.gov/gene/?term=55322 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016210 55322 C5orf22 http://www.ncbi.nlm.nih.gov/gene/?term=55322 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016211 55323 LARP6 http://www.ncbi.nlm.nih.gov/gene/?term=55323 ACHN mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016212 55323 LARP6 http://www.ncbi.nlm.nih.gov/gene/?term=55323 ACHN mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016213 55324 ABCF3 http://www.ncbi.nlm.nih.gov/gene/?term=55324 EST201864 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016214 55326 AGPAT5 http://www.ncbi.nlm.nih.gov/gene/?term=55326 "1AGPAT5, LPAATE " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016215 55327 LIN7C http://www.ncbi.nlm.nih.gov/gene/?term=55327 "LIN-7-C, LIN-7C, MALS-3, MALS3, VELI3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016216 55327 LIN7C http://www.ncbi.nlm.nih.gov/gene/?term=55327 "LIN-7-C, LIN-7C, MALS-3, MALS3, VELI3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016217 5532 PPP3CB http://www.ncbi.nlm.nih.gov/gene/?term=5532 "CALNA2, CALNB, CNA2, PP2Bbeta " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016218 5532 PPP3CB http://www.ncbi.nlm.nih.gov/gene/?term=5532 "CALNA2, CALNB, CNA2, PP2Bbeta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016219 55330 BLOC1S4 http://www.ncbi.nlm.nih.gov/gene/?term=55330 "BCAS4L, BLOS4, CNO " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016220 55331 ACER3 http://www.ncbi.nlm.nih.gov/gene/?term=55331 "APHC, PHCA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016221 55332 DRAM1 http://www.ncbi.nlm.nih.gov/gene/?term=55332 DRAM mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016222 55333 SYNJ2BP http://www.ncbi.nlm.nih.gov/gene/?term=55333 "ARIP2, OMP25 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016223 55333 SYNJ2BP http://www.ncbi.nlm.nih.gov/gene/?term=55333 "ARIP2, OMP25 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016224 55333 SYNJ2BP http://www.ncbi.nlm.nih.gov/gene/?term=55333 "ARIP2, OMP25 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016225 55334 SLC39A9 http://www.ncbi.nlm.nih.gov/gene/?term=55334 "ZIP-9, ZIP9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016226 55337 C19orf66 http://www.ncbi.nlm.nih.gov/gene/?term=55337 RyDEN mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016227 55337 C19orf66 http://www.ncbi.nlm.nih.gov/gene/?term=55337 RyDEN mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016228 55339 WDR33 http://www.ncbi.nlm.nih.gov/gene/?term=55339 "NET14, WDC146 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016229 55339 WDR33 http://www.ncbi.nlm.nih.gov/gene/?term=55339 "NET14, WDC146 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016230 5533 PPP3CC http://www.ncbi.nlm.nih.gov/gene/?term=5533 "CALNA3, CNA3, PP2Bgamma " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016231 55341 LSG1 http://www.ncbi.nlm.nih.gov/gene/?term=55341 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016232 55342 STRBP http://www.ncbi.nlm.nih.gov/gene/?term=55342 "HEL162, ILF3L, SPNR, p74 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016233 55342 STRBP http://www.ncbi.nlm.nih.gov/gene/?term=55342 "HEL162, ILF3L, SPNR, p74 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016234 55342 STRBP http://www.ncbi.nlm.nih.gov/gene/?term=55342 "HEL162, ILF3L, SPNR, p74 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016235 55343 SLC35C1 http://www.ncbi.nlm.nih.gov/gene/?term=55343 "CDG2C, FUCT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016236 55344 PLCXD1 http://www.ncbi.nlm.nih.gov/gene/?term=55344 LL0XNC01-136G2.1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016237 55346 TCP11L1 http://www.ncbi.nlm.nih.gov/gene/?term=55346 dJ85M6.3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016238 55346 TCP11L1 http://www.ncbi.nlm.nih.gov/gene/?term=55346 dJ85M6.3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016239 55347 ABHD10 http://www.ncbi.nlm.nih.gov/gene/?term=55347 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016240 55347 ABHD10 http://www.ncbi.nlm.nih.gov/gene/?term=55347 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016241 55349 CHDH http://www.ncbi.nlm.nih.gov/gene/?term=55349 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016242 5534 PPP3R1 http://www.ncbi.nlm.nih.gov/gene/?term=5534 "CALNB1, CNB, CNB1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016243 5534 PPP3R1 http://www.ncbi.nlm.nih.gov/gene/?term=5534 "CALNB1, CNB, CNB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016244 55352 COPRS http://www.ncbi.nlm.nih.gov/gene/?term=55352 "C17orf79, COPR5, HSA272196, TTP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016245 55353 LAPTM4B http://www.ncbi.nlm.nih.gov/gene/?term=55353 "LAPTM4beta, LC27 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016246 55353 LAPTM4B http://www.ncbi.nlm.nih.gov/gene/?term=55353 "LAPTM4beta, LC27 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016247 55355 HJURP http://www.ncbi.nlm.nih.gov/gene/?term=55355 "FAKTS, URLC9, hFLEG1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016248 55355 HJURP http://www.ncbi.nlm.nih.gov/gene/?term=55355 "FAKTS, URLC9, hFLEG1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016249 55355 HJURP http://www.ncbi.nlm.nih.gov/gene/?term=55355 "FAKTS, URLC9, hFLEG1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016250 55355 HJURP http://www.ncbi.nlm.nih.gov/gene/?term=55355 "FAKTS, URLC9, hFLEG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016251 55361 PI4K2A http://www.ncbi.nlm.nih.gov/gene/?term=55361 "PI4KII, PIK42A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016252 55362 TMEM63B http://www.ncbi.nlm.nih.gov/gene/?term=55362 C6orf110 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016253 55362 TMEM63B http://www.ncbi.nlm.nih.gov/gene/?term=55362 C6orf110 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016254 55363 HEMGN http://www.ncbi.nlm.nih.gov/gene/?term=55363 "CT155, EDAG, EDAG-1, NDR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016255 55364 IMPACT http://www.ncbi.nlm.nih.gov/gene/?term=55364 RWDD5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016256 55364 IMPACT http://www.ncbi.nlm.nih.gov/gene/?term=55364 RWDD5 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016257 55364 IMPACT http://www.ncbi.nlm.nih.gov/gene/?term=55364 RWDD5 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016258 55364 IMPACT http://www.ncbi.nlm.nih.gov/gene/?term=55364 RWDD5 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016259 55366 LGR4 http://www.ncbi.nlm.nih.gov/gene/?term=55366 "BNMD17, GPR48 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016260 55366 LGR4 http://www.ncbi.nlm.nih.gov/gene/?term=55366 "BNMD17, GPR48 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016261 5536 PPP5C http://www.ncbi.nlm.nih.gov/gene/?term=5536 "PP5, PPP5, PPT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016262 5536 PPP5C http://www.ncbi.nlm.nih.gov/gene/?term=5536 "PP5, PPP5, PPT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016263 5536 PPP5C http://www.ncbi.nlm.nih.gov/gene/?term=5536 "PP5, PPP5, PPT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016264 553718 nefma http://www.ncbi.nlm.nih.gov/gene/?term=553718 zgc:112359 mRNA Danio rerio 24089481 Axon Embryoneuron Whole mount in situ hybridization "Here, we provide direct evidence of the presence of mRNAs of the tubb5, nefma, and stmnb2 genes in several types of axons in the developing zebrafish (Danio rerio) embryo, with frequent accumulation at the growth cone. We further show that axonal localization of mRNA is a specific property of a subset of genes, as mRNAs of the huc and neurod genes, abundantly expressed in neurons, were not found in axons. " RLID00016265 55379 LRRC59 http://www.ncbi.nlm.nih.gov/gene/?term=55379 "PRO1855, p34 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016266 5537 PPP6C http://www.ncbi.nlm.nih.gov/gene/?term=5537 "PP6, PP6C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016267 5537 PPP6C http://www.ncbi.nlm.nih.gov/gene/?term=5537 "PP6, PP6C " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016268 5537 PPP6C http://www.ncbi.nlm.nih.gov/gene/?term=5537 "PP6, PP6C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016269 55384 MEG3 http://www.ncbi.nlm.nih.gov/gene/?term=55384 "FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 " lncRNA Homo sapiens 21625215 Cytoplasm Hepatoma cell In situ hybridization RNA in situ hybridization showed intense cytoplasmic expression of MEG3 in non-neoplastic liver with absent or very weak expression in HCC tissues. RLID00016270 55384 MEG3 http://www.ncbi.nlm.nih.gov/gene/?term=55384 "FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 " lncRNA Homo sapiens 21128942 Nucleus Brain tissue qRT-PCR|Microarray Table 2: Long noncoding RNAs represented on Affymetrix U133 arrays that were reliably detected in human nucleus accumbens. An lncRNA was considered reliably detected in human NAcc if at least one probe corresponding to the transcript gave a specific signal in all control subjects. No transcripts undetected in the controls were consistently detected in drug abusers. Data are collected from Talbe 2. RLID00016271 55384 MEG3 http://www.ncbi.nlm.nih.gov/gene/?term=55384 "FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 " lncRNA Homo sapiens 22955988 Nucleus Brain Microarray "We examined the subcellular location of a number of well-known lncRNAs (Fig. 8D). Unsurprisingly, the X-chromosome inactivating transcript XIST was extremely highly enriched in the nucleus for all cells we examined (with a maximum enrichment of 273-fold in the nucleus of GM12878 cells) (Fig. 8D). Other regulatory lncRNAs such as GAS5, LINC00568 (also known as ncRNA-a1), CYP4A22-AS1 (also known as ncRNA-a3), MIAT, and MEG3 were nuclear enriched in at least two different cell types, consistent with their reported roles in gene regulation. Other transcripts, including the bifunctional transcript SRA1, which acts as both a regulatory RNA and a protein-coding sequence, have more variable subcellular location depending on cell type. As reported previously, the H19 transcript is consistently enriched in the cytoplasm, especially when comparing with the chromatin fraction (cytoplasmic/chromatin enrichment 167-fold). " RLID00016272 55384 MEG3 http://www.ncbi.nlm.nih.gov/gene/?term=55384 "FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 " lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00016273 55384 MEG3 http://www.ncbi.nlm.nih.gov/gene/?term=55384 "FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 " lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00016274 55384 MEG3 http://www.ncbi.nlm.nih.gov/gene/?term=55384 "FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 " lncRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016275 55388 MCM10 http://www.ncbi.nlm.nih.gov/gene/?term=55388 "CNA43, DNA43, PRO2249 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016276 5538 PPT1 http://www.ncbi.nlm.nih.gov/gene/?term=5538 "CLN1, INCL, PPT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016277 5538 PPT1 http://www.ncbi.nlm.nih.gov/gene/?term=5538 "CLN1, INCL, PPT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016278 5538 PPT1 http://www.ncbi.nlm.nih.gov/gene/?term=5538 "CLN1, INCL, PPT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016279 554161 AA438147 http://www.ncbi.nlm.nih.gov/gene/?term=554161 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016280 554202 MIR31HG http://www.ncbi.nlm.nih.gov/gene/?term=554202 lncRNA Homo sapiens 25908244 Cytoplasm TIG3 cell|BJ cell qRT-PCR "Under normal conditions, MIR31HG is found in both nucleus and cytoplasm, but following B-RAF expression MIR31HG is located mainly in the cytoplasm. Under normal conditions MIR31HG is located in both the nucleus and the cytoplasm, whereas upon B-RAF expression MIR31HG is almost exclusively localized in the cytoplasm. " RLID00016281 554202 MIR31HG http://www.ncbi.nlm.nih.gov/gene/?term=554202 lncRNA Homo sapiens 25908244 Nucleus TIG3 cell|BJ cell qRT-PCR "Under normal conditions, MIR31HG is found in both nucleus and cytoplasm, but following B-RAF expression MIR31HG is located mainly in the cytoplasm. Under normal conditions MIR31HG is located in both the nucleus and the cytoplasm, whereas upon B-RAF expression MIR31HG is almost exclusively localized in the cytoplasm. " RLID00016282 55421 NCBP3 http://www.ncbi.nlm.nih.gov/gene/?term=55421 "C17orf85, ELG, HSA277841 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016283 554226 ANKRD30BL http://www.ncbi.nlm.nih.gov/gene/?term=554226 "ANKRD30BP3, NCRNA00164 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016284 55422 ZNF331 http://www.ncbi.nlm.nih.gov/gene/?term=55422 "RITA, ZNF361, ZNF463 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016285 55422 ZNF331 http://www.ncbi.nlm.nih.gov/gene/?term=55422 "RITA, ZNF361, ZNF463 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016286 554313 HIST2H4B http://www.ncbi.nlm.nih.gov/gene/?term=554313 H4/o mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016287 554327 2610042L04Rik http://www.ncbi.nlm.nih.gov/gene/?term=554327 "Tksn, takusan " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016288 55435 AP1AR http://www.ncbi.nlm.nih.gov/gene/?term=55435 "2C18, C4orf16, GBAR, PRO0971, gamma-BAR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016289 55437 STRADB http://www.ncbi.nlm.nih.gov/gene/?term=55437 "ALS2CR2, CALS-21, ILPIP, ILPIPA, PAPK, PRO1038 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016290 55437 STRADB http://www.ncbi.nlm.nih.gov/gene/?term=55437 "ALS2CR2, CALS-21, ILPIP, ILPIPA, PAPK, PRO1038 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016291 55437 STRADB http://www.ncbi.nlm.nih.gov/gene/?term=55437 "ALS2CR2, CALS-21, ILPIP, ILPIPA, PAPK, PRO1038 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016292 55449 DHRS4-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=55449 "AS1DHRS4, C14orf167, PRO1488 " lncRNA Homo sapiens 22891334 Cytoplasm HL7702 cell|HepG2 cell qRT-PCR "QPCR analysis of nuclear and cytoplasmic RNA extracts from HL7702 and HepG2 cells found that AS1DHRS4 was distributed more in the cytoplasm (60.47%) and less in the nucleus (39.53%) (SI Appendix, Fig. S3C). " RLID00016293 55449 DHRS4-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=55449 "AS1DHRS4, C14orf167, PRO1488 " lncRNA Homo sapiens 25332394 Cytoplasm - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/dhrs4-as1/ RLID00016294 55449 DHRS4-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=55449 "AS1DHRS4, C14orf167, PRO1488 " lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016295 55449 DHRS4-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=55449 "AS1DHRS4, C14orf167, PRO1488 " lncRNA Homo sapiens 22891334 Nucleus HL7702 cell|HepG2 cell qRT-PCR "QPCR analysis of nuclear and cytoplasmic RNA extracts from HL7702 and HepG2 cells found that AS1DHRS4 was distributed more in the cytoplasm (60.47%) and less in the nucleus (39.53%) (SI Appendix, Fig. S3C). " RLID00016296 55449 DHRS4-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=55449 "AS1DHRS4, C14orf167, PRO1488 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016297 55450 CAMK2N1 http://www.ncbi.nlm.nih.gov/gene/?term=55450 PRO1489 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016298 55450 CAMK2N1 http://www.ncbi.nlm.nih.gov/gene/?term=55450 PRO1489 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016299 55454 CSGALNACT2 http://www.ncbi.nlm.nih.gov/gene/?term=55454 "CHGN2, ChGn-2, GALNACT-2, GALNACT2, PRO0082, beta4GalNAcT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016300 55466 DNAJA4 http://www.ncbi.nlm.nih.gov/gene/?term=55466 "MST104, MSTP104, PRO1472 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016301 55466 DNAJA4 http://www.ncbi.nlm.nih.gov/gene/?term=55466 "MST104, MSTP104, PRO1472 " mRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00016302 5546 PRCC http://www.ncbi.nlm.nih.gov/gene/?term=5546 "RCCP1, TPRC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016303 5546 PRCC http://www.ncbi.nlm.nih.gov/gene/?term=5546 "RCCP1, TPRC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016304 5547 PRCP http://www.ncbi.nlm.nih.gov/gene/?term=5547 "HUMPCP, PCP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016305 55486 PARL http://www.ncbi.nlm.nih.gov/gene/?term=55486 "PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016306 55500 ETNK1 http://www.ncbi.nlm.nih.gov/gene/?term=55500 "EKI, EKI 1, EKI1, Nbla10396 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016307 55500 ETNK1 http://www.ncbi.nlm.nih.gov/gene/?term=55500 "EKI, EKI 1, EKI1, Nbla10396 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016308 55502 HES6 http://www.ncbi.nlm.nih.gov/gene/?term=55502 "C-HAIRY1, HES-6, bHLHb41, bHLHc23 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016309 55503 TRPV6 http://www.ncbi.nlm.nih.gov/gene/?term=55503 "ABP/ZF, CAT1, CATL, ECAC2, HSA277909, LP6728, ZFAB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016310 55505 NOP10 http://www.ncbi.nlm.nih.gov/gene/?term=55505 "DKCB1, NOLA3P, NOP10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016311 55505 NOP10 http://www.ncbi.nlm.nih.gov/gene/?term=55505 "DKCB1, NOLA3, NOP10P " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016312 55506 H2AFY2 http://www.ncbi.nlm.nih.gov/gene/?term=55506 macroH2A2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016313 5550 PREP http://www.ncbi.nlm.nih.gov/gene/?term=5550 "PE, PEP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016314 5550 PREP http://www.ncbi.nlm.nih.gov/gene/?term=5550 "PE, PEP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016315 5550 PREP http://www.ncbi.nlm.nih.gov/gene/?term=5550 "PE, PEP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016316 55511 SAGE1 http://www.ncbi.nlm.nih.gov/gene/?term=55511 "CT14, SAGE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016317 55512 SMPD3 http://www.ncbi.nlm.nih.gov/gene/?term=55512 NSMASE2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016318 55520 ELAC1 http://www.ncbi.nlm.nih.gov/gene/?term=55520 D29 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016319 55520 ELAC1 http://www.ncbi.nlm.nih.gov/gene/?term=55520 D29 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016320 55526 DHTKD1 http://www.ncbi.nlm.nih.gov/gene/?term=55526 "AMOXAD, CMT2Q " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016321 55527 FEM1A http://www.ncbi.nlm.nih.gov/gene/?term=55527 EPRAP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016322 55527 FEM1A http://www.ncbi.nlm.nih.gov/gene/?term=55527 EPRAP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016323 55527 FEM1A http://www.ncbi.nlm.nih.gov/gene/?term=55527 EPRAP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016324 5552 SRGN http://www.ncbi.nlm.nih.gov/gene/?term=5552 "PPG, PRG, PRG1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016325 55530 SVOP http://www.ncbi.nlm.nih.gov/gene/?term=55530 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016326 55530 SVOP http://www.ncbi.nlm.nih.gov/gene/?term=55530 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016327 55532 SLC30A10 http://www.ncbi.nlm.nih.gov/gene/?term=55532 "HMDPC, ZNT10, ZNT8, ZRC1, ZnT-10 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016328 55536 CDCA7L http://www.ncbi.nlm.nih.gov/gene/?term=55536 "JPO2, R1, RAM2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016329 5553 PRG2 http://www.ncbi.nlm.nih.gov/gene/?term=5553 "BMPG, MBP, MBP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016330 55540 IL17RB http://www.ncbi.nlm.nih.gov/gene/?term=55540 "CRL4, EVI27, IL17BR, IL17RH1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016331 55544 RBM38 http://www.ncbi.nlm.nih.gov/gene/?term=55544 "HSRNASEB, RNPC1, SEB4B, SEB4D, dJ800J21.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016332 55544 RBM38 http://www.ncbi.nlm.nih.gov/gene/?term=55544 "HSRNASEB, RNPC1, SEB4B, SEB4D, dJ800J21.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016333 55552 ZNF823 http://www.ncbi.nlm.nih.gov/gene/?term=55552 HSZFP36 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016334 55553 SOX6 http://www.ncbi.nlm.nih.gov/gene/?term=55553 "HSSOX6, SOXD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016335 55556 ENOSF1 http://www.ncbi.nlm.nih.gov/gene/?term=55556 "RTS, TYMSAS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016336 55556 ENOSF1 http://www.ncbi.nlm.nih.gov/gene/?term=55556 "RTS, TYMSAS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016337 55558 PLXNA3 http://www.ncbi.nlm.nih.gov/gene/?term=55558 "6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016338 55565 ZNF821 http://www.ncbi.nlm.nih.gov/gene/?term=55565 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016339 55568 GALNT10 http://www.ncbi.nlm.nih.gov/gene/?term=55568 "GALNACT10, PPGALNACT10, PPGANTASE10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016340 55568 GALNT10 http://www.ncbi.nlm.nih.gov/gene/?term=55568 "GALNACT10, PPGALNACT10, PPGANTASE10 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016341 55568 GALNT10 http://www.ncbi.nlm.nih.gov/gene/?term=55568 "GALNACT10, PPGALNACT10, PPGANTASE10 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016342 55571 CNOT11 http://www.ncbi.nlm.nih.gov/gene/?term=55571 "C2orf29, C40 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016343 55571 CNOT11 http://www.ncbi.nlm.nih.gov/gene/?term=55571 "C2orf29, C40 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016344 55572 FOXRED1 http://www.ncbi.nlm.nih.gov/gene/?term=55572 "FP634, H17 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016345 55572 FOXRED1 http://www.ncbi.nlm.nih.gov/gene/?term=55572 "FP634, H17 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016346 55573 CDV3 http://www.ncbi.nlm.nih.gov/gene/?term=55573 H41 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016347 55573 CDV3 http://www.ncbi.nlm.nih.gov/gene/?term=55573 H41 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016348 55573 CDV3 http://www.ncbi.nlm.nih.gov/gene/?term=55573 H41 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016349 55578 SUPT20H http://www.ncbi.nlm.nih.gov/gene/?term=55578 "C13, C13orf19, FAM48A, FP757, P38IP, SPT20 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016350 5557 PRIM1 http://www.ncbi.nlm.nih.gov/gene/?term=5557 p49 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016351 55585 UBE2Q1 http://www.ncbi.nlm.nih.gov/gene/?term=55585 "GTAP, NICE-5, PRO3094, UBE2Q " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016352 55585 UBE2Q1 http://www.ncbi.nlm.nih.gov/gene/?term=55585 "GTAP, NICE-5, PRO3094, UBE2Q " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016353 55588 MED29 http://www.ncbi.nlm.nih.gov/gene/?term=55588 "IXL, MED2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016354 55589 BMP2K http://www.ncbi.nlm.nih.gov/gene/?term=55589 "BIKE, HRIHFB2017 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016355 5558 PRIM2 http://www.ncbi.nlm.nih.gov/gene/?term=5558 "PRIM2A, p58 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016356 55591 VEZT http://www.ncbi.nlm.nih.gov/gene/?term=55591 VEZATIN mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016357 55592 GOLGA2P5 http://www.ncbi.nlm.nih.gov/gene/?term=55592 "GOLGA2B, GOLGA2L1 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016358 55593 OTUD5 http://www.ncbi.nlm.nih.gov/gene/?term=55593 DUBA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016359 55599 RNPC3 http://www.ncbi.nlm.nih.gov/gene/?term=55599 "RBM40, RNP, SNRNP65 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016360 55601 DDX60 http://www.ncbi.nlm.nih.gov/gene/?term=55601 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016361 55601 DDX60 http://www.ncbi.nlm.nih.gov/gene/?term=55601 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016362 55602 CDKN2AIP http://www.ncbi.nlm.nih.gov/gene/?term=55602 CARF mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016363 55604 LRRC16A http://www.ncbi.nlm.nih.gov/gene/?term=55604 "CARMIL, CARMIL1, CARMIL1a, LRRC16, dJ501N12.1, dJ501N12.5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016364 55607 PPP1R9A http://www.ncbi.nlm.nih.gov/gene/?term=55607 "NRB1, NRBI, Neurabin-I " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016365 55607 PPP1R9A http://www.ncbi.nlm.nih.gov/gene/?term=55607 "NRB1, NRBI, Neurabin-I " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016366 55607 PPP1R9A http://www.ncbi.nlm.nih.gov/gene/?term=55607 "NRB1, NRBI, Neurabin-I " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016367 55608 ANKRD10 http://www.ncbi.nlm.nih.gov/gene/?term=55608 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016368 55609 ZNF280C http://www.ncbi.nlm.nih.gov/gene/?term=55609 "SUHW3, ZNF633 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016369 55609 ZNF280C http://www.ncbi.nlm.nih.gov/gene/?term=55609 "SUHW3, ZNF633 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016370 55610 VPS50 http://www.ncbi.nlm.nih.gov/gene/?term=55610 "CCDC132, VPS54L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016371 55611 OTUB1 http://www.ncbi.nlm.nih.gov/gene/?term=55611 "HSPC263, OTB1, OTU1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016372 55612 FERMT1 http://www.ncbi.nlm.nih.gov/gene/?term=55612 "C20orf42, DTGCU2, KIND1, UNC112A, URP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016373 55614 KIF16B http://www.ncbi.nlm.nih.gov/gene/?term=55614 "C20orf23, KISC20ORF, SNX23 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016374 55615 PRR5 http://www.ncbi.nlm.nih.gov/gene/?term=55615 "FLJ20185k, PP610, PROTOR-1, PROTOR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016375 55620 STAP2 http://www.ncbi.nlm.nih.gov/gene/?term=55620 BKS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016376 55622 TTC27 http://www.ncbi.nlm.nih.gov/gene/?term=55622 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016377 55623 THUMPD1 http://www.ncbi.nlm.nih.gov/gene/?term=55623 Tan1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016378 55623 THUMPD1 http://www.ncbi.nlm.nih.gov/gene/?term=55623 Tan1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016379 55624 POMGNT1 http://www.ncbi.nlm.nih.gov/gene/?term=55624 "GNTI.2, GnT I.2, LGMD2O, MEB, MGAT1.2, gnT-I.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016380 55624 POMGNT1 http://www.ncbi.nlm.nih.gov/gene/?term=55624 "GNTI.2, GnT I.2, LGMD2O, MEB, MGAT1.2, gnT-I.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016381 55625 ZDHHC7 http://www.ncbi.nlm.nih.gov/gene/?term=55625 "DHHC7, SERZ-B, SERZ1, ZNF370 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016382 55626 AMBRA1 http://www.ncbi.nlm.nih.gov/gene/?term=55626 "DCAF3, WDR94 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016383 55626 AMBRA1 http://www.ncbi.nlm.nih.gov/gene/?term=55626 "DCAF3, WDR94 " mRNA Homo sapiens 26086269 Cytoplasm HeLa cell|HEK-293 cell Fluorescence in situ hybridization Partial re-localization of Ambra1 mRNA to non-translating fractions and cytoplasmic P-bodies was further detected. RLID00016384 55627 SMPD4 http://www.ncbi.nlm.nih.gov/gene/?term=55627 "NET13, NSMASE-3, NSMASE3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016385 55628 ZNF407 http://www.ncbi.nlm.nih.gov/gene/?term=55628 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016386 55629 PNRC2 http://www.ncbi.nlm.nih.gov/gene/?term=55629 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016387 5562 PRKAA1 http://www.ncbi.nlm.nih.gov/gene/?term=5562 "AMPK, AMPKa1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016388 5562 PRKAA1 http://www.ncbi.nlm.nih.gov/gene/?term=5562 "AMPK, AMPKa1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016389 55630 SLC39A4 http://www.ncbi.nlm.nih.gov/gene/?term=55630 "AEZ, AWMS2, ZIP4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016390 55631 LRRC40 http://www.ncbi.nlm.nih.gov/gene/?term=55631 dJ677H15.1 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016391 55632 G2E3 http://www.ncbi.nlm.nih.gov/gene/?term=55632 "KIAA1333, PHF7B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016392 55634 KRBOX4 http://www.ncbi.nlm.nih.gov/gene/?term=55634 ZNF673 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016393 55635 DEPDC1 http://www.ncbi.nlm.nih.gov/gene/?term=55635 "DEP.8-V2, DEPDC1A, SDP35, DEPDC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016394 55636 CHD7 http://www.ncbi.nlm.nih.gov/gene/?term=55636 "CRG, HH5, IS3, KAL5 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016395 5563 PRKAA2 http://www.ncbi.nlm.nih.gov/gene/?term=5563 "AMPK, AMPK2, AMPKa2, PRKAA " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00016396 55640 FLVCR2 http://www.ncbi.nlm.nih.gov/gene/?term=55640 "C14orf58, CCT, EPV, FLVCRL14q, MFSD7C, PVHH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016397 55644 OSGEP http://www.ncbi.nlm.nih.gov/gene/?term=55644 "GCPL1, KAE11, PRSMG1, OSGEP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016398 55644 OSGEP http://www.ncbi.nlm.nih.gov/gene/?term=55644 "GCPL1, KAE11, PRSMG1, OSGEP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016399 55644 OSGEP http://www.ncbi.nlm.nih.gov/gene/?term=55644 "GCPL1, KAE1, OSGEP1, PRSMG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016400 55646 LYAR http://www.ncbi.nlm.nih.gov/gene/?term=55646 "ZC2HC2, ZLYAR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016401 55646 LYAR http://www.ncbi.nlm.nih.gov/gene/?term=55646 "ZC2HC2, ZLYAR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016402 55647 RAB20 http://www.ncbi.nlm.nih.gov/gene/?term=55647 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016403 5564 PRKAB1 http://www.ncbi.nlm.nih.gov/gene/?term=5564 "AMPK, HAMPKb " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016404 5564 PRKAB1 http://www.ncbi.nlm.nih.gov/gene/?term=5564 "AMPK, HAMPKb " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016405 55650 PIGV http://www.ncbi.nlm.nih.gov/gene/?term=55650 "GPI-MT-II, HPMRS1, PIG-V " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016406 55651 NHP2 http://www.ncbi.nlm.nih.gov/gene/?term=55651 "DKCB2P, NOLA2, NHP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016407 55652 SLC48A1 http://www.ncbi.nlm.nih.gov/gene/?term=55652 "HRG-1, HRG1, hHRG-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016408 55654 TMEM127 http://www.ncbi.nlm.nih.gov/gene/?term=55654 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016409 55654 TMEM127 http://www.ncbi.nlm.nih.gov/gene/?term=55654 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016410 55654 TMEM127 http://www.ncbi.nlm.nih.gov/gene/?term=55654 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016411 55654 TMEM127 http://www.ncbi.nlm.nih.gov/gene/?term=55654 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016412 55655 NLRP2 http://www.ncbi.nlm.nih.gov/gene/?term=55655 "CLR19.9, NALP2, NBS1, PAN1, PYPAF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016413 55656 INTS8 http://www.ncbi.nlm.nih.gov/gene/?term=55656 "C8orf52, INT8 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016414 55657 ZNF692 http://www.ncbi.nlm.nih.gov/gene/?term=55657 "AREBP, Zfp692 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016415 55658 RNF126 http://www.ncbi.nlm.nih.gov/gene/?term=55658 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016416 55658 RNF126 http://www.ncbi.nlm.nih.gov/gene/?term=55658 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016417 5565 PRKAB2 http://www.ncbi.nlm.nih.gov/gene/?term=5565 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016418 55660 PRPF40A http://www.ncbi.nlm.nih.gov/gene/?term=55660 "FBP-11, FBP11, FLAF1, FNBP3, HIP-10, HIP10, HYPA, NY-REN-6, Prp40 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016419 55660 PRPF40A http://www.ncbi.nlm.nih.gov/gene/?term=55660 "FBP-11, FBP11, FLAF1, FNBP3, HIP-10, HIP10, HYPA, NY-REN-6, Prp40 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016420 55662 HIF1AN http://www.ncbi.nlm.nih.gov/gene/?term=55662 FIH1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016421 55662 HIF1AN http://www.ncbi.nlm.nih.gov/gene/?term=55662 FIH1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016422 55664 CDC37L1 http://www.ncbi.nlm.nih.gov/gene/?term=55664 "CDC37B, HARC " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016423 55664 CDC37L1 http://www.ncbi.nlm.nih.gov/gene/?term=55664 "CDC37B, HARC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016424 55665 URGCP http://www.ncbi.nlm.nih.gov/gene/?term=55665 URG4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016425 55665 URGCP http://www.ncbi.nlm.nih.gov/gene/?term=55665 URG4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016426 55666 NPLOC4 http://www.ncbi.nlm.nih.gov/gene/?term=55666 NPL4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016427 55667 DENND4C http://www.ncbi.nlm.nih.gov/gene/?term=55667 "C9orf55, C9orf55B, bA513M16.3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016428 55667 DENND4C http://www.ncbi.nlm.nih.gov/gene/?term=55667 "C9orf55, C9orf55B, bA513M16.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016429 55668 GPATCH2L http://www.ncbi.nlm.nih.gov/gene/?term=55668 C14orf118 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016430 55668 GPATCH2L http://www.ncbi.nlm.nih.gov/gene/?term=55668 C14orf118 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016431 55669 MFN1 http://www.ncbi.nlm.nih.gov/gene/?term=55669 "hfzo1, hfzo2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016432 55669 MFN1 http://www.ncbi.nlm.nih.gov/gene/?term=55669 "hfzo1, hfzo2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016433 55669 MFN1 http://www.ncbi.nlm.nih.gov/gene/?term=55669 "hfzo1, hfzo2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016434 55670 PEX26 http://www.ncbi.nlm.nih.gov/gene/?term=55670 "PBD7A, PBD7BM1T, Pex26pM1T, PEX26 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016435 55671 PPP4R3A http://www.ncbi.nlm.nih.gov/gene/?term=55671 "FLFL1, KIAA2010, MSTP033, PP4R3, PP4R3A, SMEK1, smk-1, smk1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016436 55671 PPP4R3A http://www.ncbi.nlm.nih.gov/gene/?term=55671 "FLFL1, KIAA2010, MSTP033, PP4R3, PP4R3A, SMEK1, smk-1, smk1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016437 55671 PPP4R3A http://www.ncbi.nlm.nih.gov/gene/?term=55671 "FLFL1, KIAA2010, MSTP033, PP4R3, PP4R3A, SMEK1, smk-1, smk1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016438 55672 NBPF1 http://www.ncbi.nlm.nih.gov/gene/?term=55672 "AB13, AB14, AB23, AD2, NBG, NBPF " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016439 55672 NBPF1 http://www.ncbi.nlm.nih.gov/gene/?term=55672 "AB13, AB14, AB23, AD2, NBG, NBPF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016440 55676 SLC30A6 http://www.ncbi.nlm.nih.gov/gene/?term=55676 "MST103, MSTP103, ZNT6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016441 55676 SLC30A6 http://www.ncbi.nlm.nih.gov/gene/?term=55676 "MST103, MSTP103, ZNT6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016442 55677 IWS1 http://www.ncbi.nlm.nih.gov/gene/?term=55677 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016443 55677 IWS1 http://www.ncbi.nlm.nih.gov/gene/?term=55677 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016444 55683 KANSL3 http://www.ncbi.nlm.nih.gov/gene/?term=55683 "KIAA1310, NSL3, Rcd1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016445 55686 MREG http://www.ncbi.nlm.nih.gov/gene/?term=55686 "DSU, WDT2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016446 55686 MREG http://www.ncbi.nlm.nih.gov/gene/?term=55686 "DSU, WDT2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016447 55686 MREG http://www.ncbi.nlm.nih.gov/gene/?term=55686 "DSU, WDT2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016448 55686 MREG http://www.ncbi.nlm.nih.gov/gene/?term=55686 "DSU, WDT2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016449 55687 TRMU http://www.ncbi.nlm.nih.gov/gene/?term=55687 "LCAL3, MTO2, MTU1, TRMT, TRMT1, TRNT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016450 55689 YEATS2 http://www.ncbi.nlm.nih.gov/gene/?term=55689 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016451 55690 PACS1 http://www.ncbi.nlm.nih.gov/gene/?term=55690 MRD17 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016452 55692 LUC7L http://www.ncbi.nlm.nih.gov/gene/?term=55692 "LUC7B1, Luc7, SR+89, hLuc7B1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016453 55696 RBM22 http://www.ncbi.nlm.nih.gov/gene/?term=55696 "Cwc2, ZC3H16, fSAP47 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016454 55696 RBM22 http://www.ncbi.nlm.nih.gov/gene/?term=55696 "Cwc2, ZC3H16, fSAP47 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016455 55696 RBM22 http://www.ncbi.nlm.nih.gov/gene/?term=55696 "Cwc2, ZC3H16, fSAP47 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016456 55697 VAC14 http://www.ncbi.nlm.nih.gov/gene/?term=55697 "ArPIKfyve, TAX1BP2, TRX " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016457 55699 IARS2 http://www.ncbi.nlm.nih.gov/gene/?term=55699 "CAGSSS, ILERS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016458 5569 PKIA http://www.ncbi.nlm.nih.gov/gene/?term=5569 PRKACN1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016459 5569 PKIA http://www.ncbi.nlm.nih.gov/gene/?term=5569 PRKACN1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016460 55700 MAP7D1 http://www.ncbi.nlm.nih.gov/gene/?term=55700 "PARCC1, RPRC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016461 55700 MAP7D1 http://www.ncbi.nlm.nih.gov/gene/?term=55700 "PARCC1, RPRC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016462 55701 ARHGEF40 http://www.ncbi.nlm.nih.gov/gene/?term=55701 SOLO mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016463 55702 CCDC94 http://www.ncbi.nlm.nih.gov/gene/?term=55702 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016464 55704 CCDC88A http://www.ncbi.nlm.nih.gov/gene/?term=55704 "APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016465 55704 CCDC88A http://www.ncbi.nlm.nih.gov/gene/?term=55704 "APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016466 55705 IPO9 http://www.ncbi.nlm.nih.gov/gene/?term=55705 Imp9 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016467 55705 IPO9 http://www.ncbi.nlm.nih.gov/gene/?term=55705 Imp9 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016468 55705 IPO9 http://www.ncbi.nlm.nih.gov/gene/?term=55705 Imp9 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016469 55707 NECAP2 http://www.ncbi.nlm.nih.gov/gene/?term=55707 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016470 5570 PKIB http://www.ncbi.nlm.nih.gov/gene/?term=5570 PRKACN2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016471 5570 PKIB http://www.ncbi.nlm.nih.gov/gene/?term=5570 PRKACN2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016472 55711 FAR2 http://www.ncbi.nlm.nih.gov/gene/?term=55711 "HEL-S-81, MLSTD1, SDR10E2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016473 55717 WDR11 http://www.ncbi.nlm.nih.gov/gene/?term=55717 "BRWD2, DR11, HH14, WDR15 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016474 55717 WDR11 http://www.ncbi.nlm.nih.gov/gene/?term=55717 "BRWD2, DR11, HH14, WDR15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016475 55718 POLR3E http://www.ncbi.nlm.nih.gov/gene/?term=55718 "RPC5, SIN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016476 55718 POLR3E http://www.ncbi.nlm.nih.gov/gene/?term=55718 "RPC5, SIN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016477 55719 SLF2 http://www.ncbi.nlm.nih.gov/gene/?term=55719 "C10orf6, FAM178A " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016478 5571 PRKAG1 http://www.ncbi.nlm.nih.gov/gene/?term=5571 AMPKG mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016479 5571 PRKAG1 http://www.ncbi.nlm.nih.gov/gene/?term=5571 AMPKG mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016480 55720 TSR1 http://www.ncbi.nlm.nih.gov/gene/?term=55720 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016481 55723 ASF1B http://www.ncbi.nlm.nih.gov/gene/?term=55723 CIA-II mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016482 55723 ASF1B http://www.ncbi.nlm.nih.gov/gene/?term=55723 CIA-II mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016483 55726 ASUN http://www.ncbi.nlm.nih.gov/gene/?term=55726 "C12orf11, GCT1, Mat89Bb, NET48, SPATA30 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016484 55726 ASUN http://www.ncbi.nlm.nih.gov/gene/?term=55726 "C12orf11, GCT1, Mat89Bb, NET48, SPATA30 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016485 55727 BTBD7 http://www.ncbi.nlm.nih.gov/gene/?term=55727 FUP1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016486 55728 N4BP2 http://www.ncbi.nlm.nih.gov/gene/?term=55728 B3BP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016487 55728 N4BP2 http://www.ncbi.nlm.nih.gov/gene/?term=55728 B3BP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016488 55729 ATF7IP http://www.ncbi.nlm.nih.gov/gene/?term=55729 "AM, ATF-IP, MCAF, MCAF1, p621 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016489 55731 FAM222B http://www.ncbi.nlm.nih.gov/gene/?term=55731 C17orf63 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016490 55732 C1orf112 http://www.ncbi.nlm.nih.gov/gene/?term=55732 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016491 55734 ZFP64 http://www.ncbi.nlm.nih.gov/gene/?term=55734 ZNF338 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016492 55734 ZFP64 http://www.ncbi.nlm.nih.gov/gene/?term=55734 ZNF338 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016493 55735 DNAJC11 http://www.ncbi.nlm.nih.gov/gene/?term=55735 dJ126A5.1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016494 55735 DNAJC11 http://www.ncbi.nlm.nih.gov/gene/?term=55735 dJ126A5.1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016495 55737 VPS35 http://www.ncbi.nlm.nih.gov/gene/?term=55737 "MEM3, PARK17 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016496 55737 VPS35 http://www.ncbi.nlm.nih.gov/gene/?term=55737 "MEM3, PARK17 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016497 55737 VPS35 http://www.ncbi.nlm.nih.gov/gene/?term=55737 "MEM3, PARK17 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016498 55738 ARFGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=55738 "ARF1GAP, HRIHFB2281 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016499 55739 NAXD http://www.ncbi.nlm.nih.gov/gene/?term=55739 LP3298 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016500 5573 PRKAR1A http://www.ncbi.nlm.nih.gov/gene/?term=5573 "ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016501 5573 PRKAR1A http://www.ncbi.nlm.nih.gov/gene/?term=5573 "ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016502 55740 ENAH http://www.ncbi.nlm.nih.gov/gene/?term=55740 "ENA, MENA, NDPP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016503 55740 ENAH http://www.ncbi.nlm.nih.gov/gene/?term=55740 "ENA, MENA, NDPP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016504 55740 ENAH http://www.ncbi.nlm.nih.gov/gene/?term=55740 "ENA, MENA, NDPP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016505 55740 ENAH http://www.ncbi.nlm.nih.gov/gene/?term=55740 "ENA, MENA, NDPP1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016506 55741 EDEM2 http://www.ncbi.nlm.nih.gov/gene/?term=55741 "C20orf31, C20orf49, bA4204.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016507 55742 PARVA http://www.ncbi.nlm.nih.gov/gene/?term=55742 "CH-ILKBP, MXRA2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016508 55743 CHFR http://www.ncbi.nlm.nih.gov/gene/?term=55743 "RNF116, RNF196 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016509 55744 COA1 http://www.ncbi.nlm.nih.gov/gene/?term=55744 "C7orf44, MITRAC15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016510 55744 COA1 http://www.ncbi.nlm.nih.gov/gene/?term=55744 "C7orf44, MITRAC15 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016511 55745 AP5M1 http://www.ncbi.nlm.nih.gov/gene/?term=55745 "C14orf108, MUDENG, Mu5, MuD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016512 55746 NUP133 http://www.ncbi.nlm.nih.gov/gene/?term=55746 hNUP133 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016513 55746 NUP133 http://www.ncbi.nlm.nih.gov/gene/?term=55746 hNUP133 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016514 55748 CNDP2 http://www.ncbi.nlm.nih.gov/gene/?term=55748 "CN2, CPGL, HEL-S-13, HsT2298, PEPA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016515 55749 CCAR1 http://www.ncbi.nlm.nih.gov/gene/?term=55749 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016516 55749 CCAR1 http://www.ncbi.nlm.nih.gov/gene/?term=55749 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016517 55750 AGK http://www.ncbi.nlm.nih.gov/gene/?term=55750 "CATC5, CTRCT38, MTDPS10, MULK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016518 55751 TMEM184C http://www.ncbi.nlm.nih.gov/gene/?term=55751 TMEM34 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016519 55751 TMEM184C http://www.ncbi.nlm.nih.gov/gene/?term=55751 TMEM34 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016520 55751 TMEM184C http://www.ncbi.nlm.nih.gov/gene/?term=55751 TMEM34 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016521 55752 SEPT11 http://www.ncbi.nlm.nih.gov/gene/?term=55752 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016522 55753 OGDHL http://www.ncbi.nlm.nih.gov/gene/?term=55753 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016523 55754 TMEM30A http://www.ncbi.nlm.nih.gov/gene/?term=55754 "C6orf67, CDC50A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016524 55754 TMEM30A http://www.ncbi.nlm.nih.gov/gene/?term=55754 "C6orf67, CDC50A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016525 55757 UGGT2 http://www.ncbi.nlm.nih.gov/gene/?term=55757 "HUGT2, UGCGL2, UGT2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016526 55758 RCOR3 http://www.ncbi.nlm.nih.gov/gene/?term=55758 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016527 55758 RCOR3 http://www.ncbi.nlm.nih.gov/gene/?term=55758 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016528 55759 WDR12 http://www.ncbi.nlm.nih.gov/gene/?term=55759 YTM1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016529 5575 PRKAR1B http://www.ncbi.nlm.nih.gov/gene/?term=5575 PRKAR1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016530 5575 PRKAR1B http://www.ncbi.nlm.nih.gov/gene/?term=5575 PRKAR1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016531 55760 DHX32 http://www.ncbi.nlm.nih.gov/gene/?term=55760 "DDX32, DHLP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016532 55761 TTC17 http://www.ncbi.nlm.nih.gov/gene/?term=55761 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016533 55761 TTC17 http://www.ncbi.nlm.nih.gov/gene/?term=55761 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016534 55763 EXOC1 http://www.ncbi.nlm.nih.gov/gene/?term=55763 "BM-102, SEC3, SEC3L1, SEC3P " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016535 55766 H2AFJ http://www.ncbi.nlm.nih.gov/gene/?term=55766 H2AJ mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016536 55768 NGLY1 http://www.ncbi.nlm.nih.gov/gene/?term=55768 "CDDG, CDG1V, PNG1, PNGase " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016537 55769 ZNF83 http://www.ncbi.nlm.nih.gov/gene/?term=55769 "HPF1, ZNF816B " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016538 55769 ZNF83 http://www.ncbi.nlm.nih.gov/gene/?term=55769 "HPF1, ZNF816B " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016539 5576 PRKAR2A http://www.ncbi.nlm.nih.gov/gene/?term=5576 "PKR2, PRKAR2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016540 55771 PRR11 http://www.ncbi.nlm.nih.gov/gene/?term=55771 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016541 55773 TBC1D23 http://www.ncbi.nlm.nih.gov/gene/?term=55773 NS4ATP1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016542 55773 TBC1D23 http://www.ncbi.nlm.nih.gov/gene/?term=55773 NS4ATP1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016543 55776 SAYSD1 http://www.ncbi.nlm.nih.gov/gene/?term=55776 C6orf64 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016544 55776 SAYSD1 http://www.ncbi.nlm.nih.gov/gene/?term=55776 C6orf64 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016545 5577 PRKAR2B http://www.ncbi.nlm.nih.gov/gene/?term=5577 "PRKAR2, RII-BETA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016546 5577 PRKAR2B http://www.ncbi.nlm.nih.gov/gene/?term=5577 "PRKAR2, RII-BETA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016547 55783 CMTR2 http://www.ncbi.nlm.nih.gov/gene/?term=55783 "AFT, FTSJD1, HMTr2, MTr2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016548 55783 CMTR2 http://www.ncbi.nlm.nih.gov/gene/?term=55783 "AFT, FTSJD1, HMTr2, MTr2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016549 55785 FGD6 http://www.ncbi.nlm.nih.gov/gene/?term=55785 ZFYVE24 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016550 55785 FGD6 http://www.ncbi.nlm.nih.gov/gene/?term=55785 ZFYVE24 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016551 55789 DEPDC1B http://www.ncbi.nlm.nih.gov/gene/?term=55789 "BRCC3, XTP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016552 55789 DEPDC1B http://www.ncbi.nlm.nih.gov/gene/?term=55789 "BRCC3, XTP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016553 5578 PRKCA http://www.ncbi.nlm.nih.gov/gene/?term=5578 "AAG6, PKC-alpha, PKCA, PRKACA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016554 5578 PRKCA http://www.ncbi.nlm.nih.gov/gene/?term=5578 "AAG6, PKC-alpha, PKCA, PRKACA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016555 5578 PRKCA http://www.ncbi.nlm.nih.gov/gene/?term=5578 "AAG6, PKC-alpha, PKCA, PRKACA " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016556 5578 PRKCA http://www.ncbi.nlm.nih.gov/gene/?term=5578 "AAG6, PKC-alpha, PKCA, PRKACA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016557 55791 LRIF1 http://www.ncbi.nlm.nih.gov/gene/?term=55791 "C1orf103, RIF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016558 55793 FAM63A http://www.ncbi.nlm.nih.gov/gene/?term=55793 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016559 55793 FAM63A http://www.ncbi.nlm.nih.gov/gene/?term=55793 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016560 55793 FAM63A http://www.ncbi.nlm.nih.gov/gene/?term=55793 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016561 55794 DDX28 http://www.ncbi.nlm.nih.gov/gene/?term=55794 MDDX28 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016562 55794 DDX28 http://www.ncbi.nlm.nih.gov/gene/?term=55794 MDDX28 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016563 55795 PCID2 http://www.ncbi.nlm.nih.gov/gene/?term=55795 F10 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016564 55795 PCID2 http://www.ncbi.nlm.nih.gov/gene/?term=55795 F10 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016565 55796 MBNL3 http://www.ncbi.nlm.nih.gov/gene/?term=55796 "CHCR, MBLX, MBLX39, MBXL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016566 55798 METTL2B http://www.ncbi.nlm.nih.gov/gene/?term=55798 "METL, METTL2, METTL2A, PSENIP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016567 5579 PRKCB http://www.ncbi.nlm.nih.gov/gene/?term=5579 "PKC-beta, PKCB1, PRKCB2, PRKCB " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00016568 5579 PRKCB http://www.ncbi.nlm.nih.gov/gene/?term=5579 "PKC-beta, PKCB, PRKCB1, PRKCB2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016569 5579 PRKCB http://www.ncbi.nlm.nih.gov/gene/?term=5579 "PKCB, PRKCB1, PRKCB2, PKC-beta " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00016570 55802 DCP1A http://www.ncbi.nlm.nih.gov/gene/?term=55802 "HSA275986, Nbla00360, SMAD4IP1, SMIF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016571 55802 DCP1A http://www.ncbi.nlm.nih.gov/gene/?term=55802 "HSA275986, Nbla00360, SMAD4IP1, SMIF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016572 55803 ADAP2 http://www.ncbi.nlm.nih.gov/gene/?term=55803 "CENTA2, HSA272195, cent-b " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016573 55803 ADAP2 http://www.ncbi.nlm.nih.gov/gene/?term=55803 "CENTA2, HSA272195, cent-b " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016574 55806 HR http://www.ncbi.nlm.nih.gov/gene/?term=55806 "ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016575 55806 HR http://www.ncbi.nlm.nih.gov/gene/?term=55806 "ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016576 5580 PRKCD http://www.ncbi.nlm.nih.gov/gene/?term=5580 "ALPS3, CVID9, MAY1, PKCD, nPKC-delta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016577 55814 BDP1 http://www.ncbi.nlm.nih.gov/gene/?term=55814 "HSA238520, TAF3B1, TFC5, TFIIIB'', TFIIIB150, TFIIIB90, TFNR " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016578 55819 RNF130 http://www.ncbi.nlm.nih.gov/gene/?term=55819 "G1RZFP, GOLIATH, GP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016579 55824 PAG1 http://www.ncbi.nlm.nih.gov/gene/?term=55824 "CBP, PAG " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016580 55824 PAG1 http://www.ncbi.nlm.nih.gov/gene/?term=55824 "CBP, PAG " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016581 55825 PECR http://www.ncbi.nlm.nih.gov/gene/?term=55825 "DCRRP, HPDHASE, HSA250303, PVIARL, SDR29C1, TERP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016582 55827 DCAF6 http://www.ncbi.nlm.nih.gov/gene/?term=55827 "1200006M05Rik, ARCAP, IQWD1, MSTP055, NRIP, PC326 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016583 55829 VIMP http://www.ncbi.nlm.nih.gov/gene/?term=55829 "AD-015, ADO15, SBBI8, SELS, SEPS1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016584 55829 VIMP http://www.ncbi.nlm.nih.gov/gene/?term=55829 "AD-015, ADO15, SBBI8, SELS, SEPS1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016585 5582 PRKCG http://www.ncbi.nlm.nih.gov/gene/?term=5582 "PKC-gamma, PKCC, PKCG, SCA14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016586 55830 GLT8D1 http://www.ncbi.nlm.nih.gov/gene/?term=55830 "AD-017, MSTP139 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016587 55831 EMC3 http://www.ncbi.nlm.nih.gov/gene/?term=55831 "POB, TMEM111 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016588 55832 CAND1 http://www.ncbi.nlm.nih.gov/gene/?term=55832 "TIP120, TIP120A " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016589 55832 CAND1 http://www.ncbi.nlm.nih.gov/gene/?term=55832 "TIP120, TIP120A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016590 55833 UBAP2 http://www.ncbi.nlm.nih.gov/gene/?term=55833 UBAP-2 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016591 55833 UBAP2 http://www.ncbi.nlm.nih.gov/gene/?term=55833 UBAP-2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016592 55835 CENPJ http://www.ncbi.nlm.nih.gov/gene/?term=55835 "BM032, CENP-J, CPAP, LAP, LIP1, MCPH6, SASS4, SCKL4, Sas-4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016593 55835 CENPJ http://www.ncbi.nlm.nih.gov/gene/?term=55835 "BM032, CENP-J, CPAP, LAP, LIP1, MCPH6, SASS4, SCKL4, Sas-4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016594 55837 EAPP http://www.ncbi.nlm.nih.gov/gene/?term=55837 "BM036, C14orf11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016595 55837 EAPP http://www.ncbi.nlm.nih.gov/gene/?term=55837 "BM036, C14orf11 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016596 55837 EAPP http://www.ncbi.nlm.nih.gov/gene/?term=55837 "BM036, C14orf11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016597 55839 CENPN http://www.ncbi.nlm.nih.gov/gene/?term=55839 "BM039, C16orf60, CENP-N, ICEN32 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016598 55839 CENPN http://www.ncbi.nlm.nih.gov/gene/?term=55839 "BM039, C16orf60, CENP-N, ICEN32 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016599 5583 PRKCH http://www.ncbi.nlm.nih.gov/gene/?term=5583 "PKC-L, PKCL, PRKCL, nPKC-eta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016600 55843 ARHGAP15 http://www.ncbi.nlm.nih.gov/gene/?term=55843 BM046 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016601 55845 BRK1 http://www.ncbi.nlm.nih.gov/gene/?term=55845 "C3orf10, HSPC300, MDS027, hHBrk1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016602 55845 BRK1 http://www.ncbi.nlm.nih.gov/gene/?term=55845 "C3orf10, HSPC300, MDS027, hHBrk1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016603 55847 CISD1 http://www.ncbi.nlm.nih.gov/gene/?term=55847 "C10orf70, MDS029, ZCD1, mitoNEET " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016604 55847 CISD1 http://www.ncbi.nlm.nih.gov/gene/?term=55847 "C10orf70, MDS029, ZCD1, mitoNEET " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016605 55848 PLGRKT http://www.ncbi.nlm.nih.gov/gene/?term=55848 "AD025, C9orf46, MDS030, PLG-RKT, Plg-R(KT) " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016606 5584 PRKCI http://www.ncbi.nlm.nih.gov/gene/?term=5584 "DXS1179E, PKCI, nPKC-iota " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016607 5584 PRKCI http://www.ncbi.nlm.nih.gov/gene/?term=5584 "DXS1179E, PKCI, nPKC-iota " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016608 5584 PRKCI http://www.ncbi.nlm.nih.gov/gene/?term=5584 "DXS1179E, PKCI, nPKC-iota " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016609 55850 USE1 http://www.ncbi.nlm.nih.gov/gene/?term=55850 "D12, MDS032, P31, SLT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016610 55851 PSENEN http://www.ncbi.nlm.nih.gov/gene/?term=55851 "MDS033, MSTP064, PEN-2, PEN2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016611 55851 PSENEN http://www.ncbi.nlm.nih.gov/gene/?term=55851 "MDS033, MSTP064, PEN-2, PEN2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016612 55851 PSENEN http://www.ncbi.nlm.nih.gov/gene/?term=55851 "MDS033, MSTP064, PEN-2, PEN2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016613 55852 TEX2 http://www.ncbi.nlm.nih.gov/gene/?term=55852 "HT008, TMEM96 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016614 55854 ZC3H15 http://www.ncbi.nlm.nih.gov/gene/?term=55854 "HT010, LEREPO4, MSTP012 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016615 55854 ZC3H15 http://www.ncbi.nlm.nih.gov/gene/?term=55854 "HT010, LEREPO4, MSTP012 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016616 55854 ZC3H15 http://www.ncbi.nlm.nih.gov/gene/?term=55854 "HT010, LEREPO4, MSTP012 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016617 55856 ACOT13 http://www.ncbi.nlm.nih.gov/gene/?term=55856 "HT012, PNAS-27, THEM2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016618 55857 KIZ http://www.ncbi.nlm.nih.gov/gene/?term=55857 "C20orf19, HT013, Kizuna, NCRNA00153, PLK1S1, RP69 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016619 55858 TMEM165 http://www.ncbi.nlm.nih.gov/gene/?term=55858 "CDG2K, FT27, GDT1, TMPT27, TPARL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016620 55858 TMEM165 http://www.ncbi.nlm.nih.gov/gene/?term=55858 "CDG2K, FT27, GDT1, TMPT27, TPARL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016621 55859 BEX1 http://www.ncbi.nlm.nih.gov/gene/?term=55859 "BEX2, HBEX2, HGR74-h " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016622 55859 BEX1 http://www.ncbi.nlm.nih.gov/gene/?term=55859 "BEX2, HBEX2, HGR74-h " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016623 5585 PKN1 http://www.ncbi.nlm.nih.gov/gene/?term=5585 "DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016624 55860 ACTR10 http://www.ncbi.nlm.nih.gov/gene/?term=55860 "ACTR11, Arp10, Arp11, HARP11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016625 55860 ACTR10 http://www.ncbi.nlm.nih.gov/gene/?term=55860 "ACTR11, Arp10, Arp11, HARP11 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016626 55860 ACTR10 http://www.ncbi.nlm.nih.gov/gene/?term=55860 "ACTR11, Arp10, Arp11, HARP11 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016627 55861 DBNDD2 http://www.ncbi.nlm.nih.gov/gene/?term=55861 "C20orf35, CK1BP, HSMNP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016628 55862 ECHDC1 http://www.ncbi.nlm.nih.gov/gene/?term=55862 "HEL-S-76, MMCD, dJ351K20.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016629 55862 ECHDC1 http://www.ncbi.nlm.nih.gov/gene/?term=55862 "HEL-S-76, MMCD, dJ351K20.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016630 55863 TMEM126B http://www.ncbi.nlm.nih.gov/gene/?term=55863 HT007 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016631 55869 HDAC8 http://www.ncbi.nlm.nih.gov/gene/?term=55869 "CDA07, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016632 5586 PKN2 http://www.ncbi.nlm.nih.gov/gene/?term=5586 "PAK2, PRK2, PRKCL2, PRO2042, Pak-2, STK7 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016633 55870 ASH1L http://www.ncbi.nlm.nih.gov/gene/?term=55870 "ASH11, KMT2H, ASH1L " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016634 55871 CBWD1 http://www.ncbi.nlm.nih.gov/gene/?term=55871 COBP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016635 55871 CBWD1 http://www.ncbi.nlm.nih.gov/gene/?term=55871 COBP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016636 55872 PBK http://www.ncbi.nlm.nih.gov/gene/?term=55872 "CT84, HEL164, Nori-3, SPK, TOPK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016637 55872 PBK http://www.ncbi.nlm.nih.gov/gene/?term=55872 "CT84, HEL164, Nori-3, SPK, TOPK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016638 55884 WSB2 http://www.ncbi.nlm.nih.gov/gene/?term=55884 SBA2 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016639 5588 PRKCQ http://www.ncbi.nlm.nih.gov/gene/?term=5588 "PRKCT, nPKC-theta " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016640 55892 MYNN http://www.ncbi.nlm.nih.gov/gene/?term=55892 "OSZF, SBBIZ1, ZBTB31, ZNF902 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016641 55892 MYNN http://www.ncbi.nlm.nih.gov/gene/?term=55892 "OSZF, SBBIZ1, ZBTB31, ZNF902 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016642 55893 ZNF395 http://www.ncbi.nlm.nih.gov/gene/?term=55893 "HDBP-2, HDBP2, HDRF-2, PBF, PRF-1, PRF1, Si-1-8-14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016643 55893 ZNF395 http://www.ncbi.nlm.nih.gov/gene/?term=55893 "HDBP-2, HDBP2, HDRF-2, PBF, PRF-1, PRF1, Si-1-8-14 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016644 55898 UNC45A http://www.ncbi.nlm.nih.gov/gene/?term=55898 "GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016645 55898 UNC45A http://www.ncbi.nlm.nih.gov/gene/?term=55898 "GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016646 55898 UNC45A http://www.ncbi.nlm.nih.gov/gene/?term=55898 "GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UN, C-45A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016647 5589 PRKCSH http://www.ncbi.nlm.nih.gov/gene/?term=5589 "AGE-R2, G19P1, GIIB, PCLD, PKCSH, PLD1, VASAP-60 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016648 5589 PRKCSH http://www.ncbi.nlm.nih.gov/gene/?term=5589 "AGE-R2, G19P1, PCLD, PKCSH, PLD1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016649 558 AXL http://www.ncbi.nlm.nih.gov/gene/?term=558 "ARK, JTK11, Tyro7, UFO " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016650 558 AXL http://www.ncbi.nlm.nih.gov/gene/?term=558 "ARK, JTK11, Tyro7, UFO " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016651 558 AXL http://www.ncbi.nlm.nih.gov/gene/?term=558 "ARK, JTK11, Tyro7, UFO " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016652 55902 ACSS2 http://www.ncbi.nlm.nih.gov/gene/?term=55902 "ACAS2, ACECS, ACS, ACSA, dJ1161H23.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016653 55902 ACSS2 http://www.ncbi.nlm.nih.gov/gene/?term=55902 "ACAS2, ACECS, ACS, ACSA, dJ1161H23.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016654 55904 KMT2E http://www.ncbi.nlm.nih.gov/gene/?term=55904 "HDCMC04P, MLL5, NKp44L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016655 55905 RNF114 http://www.ncbi.nlm.nih.gov/gene/?term=55905 "PSORS12, ZNF313 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016656 55905 RNF114 http://www.ncbi.nlm.nih.gov/gene/?term=55905 "PSORS12, ZNF313 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016657 55907 CMAS http://www.ncbi.nlm.nih.gov/gene/?term=55907 CSS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016658 55907 CMAS http://www.ncbi.nlm.nih.gov/gene/?term=55907 CSS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016659 55909 BIN3 http://www.ncbi.nlm.nih.gov/gene/?term=55909 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016660 55909 BIN3 http://www.ncbi.nlm.nih.gov/gene/?term=55909 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016661 5590 PRKCZ http://www.ncbi.nlm.nih.gov/gene/?term=5590 "PKC-ZETA, PKC2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016662 5590 PRKCZ http://www.ncbi.nlm.nih.gov/gene/?term=5590 "PKC-ZETA, PKC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016663 55914 ERBIN http://www.ncbi.nlm.nih.gov/gene/?term=55914 "ERBB2IP, HEL-S-78, LAP2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016664 55915 LANCL2 http://www.ncbi.nlm.nih.gov/gene/?term=55915 "GPR69B, TASP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016665 55916 NXT2 http://www.ncbi.nlm.nih.gov/gene/?term=55916 P15-2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016666 55917 CTTNBP2NL http://www.ncbi.nlm.nih.gov/gene/?term=55917 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016667 5591 PRKDC http://www.ncbi.nlm.nih.gov/gene/?term=5591 "DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, IMD26, XRCC7, p350 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016668 5591 PRKDC http://www.ncbi.nlm.nih.gov/gene/?term=5591 "DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, IMD26, XRCC7, p350 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016669 55920 RCC2 http://www.ncbi.nlm.nih.gov/gene/?term=55920 TD-60 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016670 55920 RCC2 http://www.ncbi.nlm.nih.gov/gene/?term=55920 TD-60 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016671 55922 NKRF http://www.ncbi.nlm.nih.gov/gene/?term=55922 "ITBA4, NRF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016672 55922 NKRF http://www.ncbi.nlm.nih.gov/gene/?term=55922 "ITBA4, NRF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016673 55924 FAM212B http://www.ncbi.nlm.nih.gov/gene/?term=55924 C1orf183 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016674 55924 FAM212B http://www.ncbi.nlm.nih.gov/gene/?term=55924 C1orf183 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016675 55927 Hes6 http://www.ncbi.nlm.nih.gov/gene/?term=55927 "AI326893, bHLHb41 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016676 55930 MYO5C http://www.ncbi.nlm.nih.gov/gene/?term=55930 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016677 55930 MYO5C http://www.ncbi.nlm.nih.gov/gene/?term=55930 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016678 55930 MYO5C http://www.ncbi.nlm.nih.gov/gene/?term=55930 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016679 55934 Rp9 http://www.ncbi.nlm.nih.gov/gene/?term=55934 "PAP-1h, Rp9 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016680 55935 Fnbp4 http://www.ncbi.nlm.nih.gov/gene/?term=55935 "FBP30, Fnbp30, mKIAA1014 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016681 55937 APOM http://www.ncbi.nlm.nih.gov/gene/?term=55937 "G3a, HSPC336, NG20, apo-M " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016682 55947 Dclre1a http://www.ncbi.nlm.nih.gov/gene/?term=55947 "2810043H12Rik, AU022226, Pso2, Smn1a, Snm1, mKIAA0086 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016683 5594 MAPK1 http://www.ncbi.nlm.nih.gov/gene/?term=5594 "ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016684 5594 MAPK1 http://www.ncbi.nlm.nih.gov/gene/?term=5594 "ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00016685 5594 MAPK1 http://www.ncbi.nlm.nih.gov/gene/?term=5594 "ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016686 5594 MAPK1 http://www.ncbi.nlm.nih.gov/gene/?term=5594 "ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016687 5594 MAPK1 http://www.ncbi.nlm.nih.gov/gene/?term=5594 "ERK, p38, p40, p41, ERK2, ERT1, ERK-2, MAPK2, PRKM1, PRKM2, P42MAPK, p41mapk, p42-MAPK " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00016688 55954 ZMAT5 http://www.ncbi.nlm.nih.gov/gene/?term=55954 "SNRNP20, U11/U12-20K, ZC3H19 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016689 55954 ZMAT5 http://www.ncbi.nlm.nih.gov/gene/?term=55954 "SNRNP20, U11/U12-20K, ZC3H19 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016690 55954 ZMAT5 http://www.ncbi.nlm.nih.gov/gene/?term=55954 "SNRNP20, U11/U12-20K, ZC3H19 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016691 55957 LIN37 http://www.ncbi.nlm.nih.gov/gene/?term=55957 "F25965, ZK418.4, lin-37 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016692 55958 KLHL9 http://www.ncbi.nlm.nih.gov/gene/?term=55958 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016693 55958 KLHL9 http://www.ncbi.nlm.nih.gov/gene/?term=55958 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016694 55963 Slc1a4 http://www.ncbi.nlm.nih.gov/gene/?term=55963 "ASCT-1, ASCT1, AW045657, SATT " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016695 55967 NDUFA12 http://www.ncbi.nlm.nih.gov/gene/?term=55967 "B17.2, DAP13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016696 55968 NSFL1C http://www.ncbi.nlm.nih.gov/gene/?term=55968 "P47, UBX1, UBXD10, UBXN2C, dJ776F14.1 " lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00016697 55968 NSFL1C http://www.ncbi.nlm.nih.gov/gene/?term=55968 "P47, UBX1, UBXD10, UBXN2C, dJ776F14.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016698 55969 C20orf24 http://www.ncbi.nlm.nih.gov/gene/?term=55969 "PNAS-11, RIP5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016699 55970 GNG12 http://www.ncbi.nlm.nih.gov/gene/?term=55970 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016700 55970 GNG12 http://www.ncbi.nlm.nih.gov/gene/?term=55970 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016701 55971 BAIAP2L1 http://www.ncbi.nlm.nih.gov/gene/?term=55971 IRTKS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016702 55973 BCAP29 http://www.ncbi.nlm.nih.gov/gene/?term=55973 BAP29 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016703 55978 Ift20 http://www.ncbi.nlm.nih.gov/gene/?term=55978 "0610009H04Rik, AU015496 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016704 55979 Agpat1 http://www.ncbi.nlm.nih.gov/gene/?term=55979 "1-AGP, 1-AGPAT, AW047140 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016705 5597 MAPK6 http://www.ncbi.nlm.nih.gov/gene/?term=5597 "ERK3, HsT17250, PRKM6, p97MAPK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016706 5597 MAPK6 http://www.ncbi.nlm.nih.gov/gene/?term=5597 "ERK3, HsT17250, PRKM6, p97MAPK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016707 55980 Impa1 http://www.ncbi.nlm.nih.gov/gene/?term=55980 "2610002K09Rik, 2900059K10Rik, AI325909 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016708 55982 Paxip1 http://www.ncbi.nlm.nih.gov/gene/?term=55982 "D5Ertd149e, PTIP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016709 55989 Nop58 http://www.ncbi.nlm.nih.gov/gene/?term=55989 "MSSP, Nol5, SIK, nop5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016710 5599 MAPK8 http://www.ncbi.nlm.nih.gov/gene/?term=5599 "JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016711 55 ACPP http://www.ncbi.nlm.nih.gov/gene/?term=55 "5'-NT, ACP-3, ACP3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016712 56005 MYDGF http://www.ncbi.nlm.nih.gov/gene/?term=56005 "C19orf10, EUROIMAGE1875335, IL25, IL27, IL27w, R33729_1, SF20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016713 56018 Stard10 http://www.ncbi.nlm.nih.gov/gene/?term=56018 "AV048538, CGI-52, NY-C0-28, PC-TP2, PCTP2, Pctpl, Sdccag28, SdccagG28, TISP-81 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016714 5601 MAPK9 http://www.ncbi.nlm.nih.gov/gene/?term=5601 "JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016715 5601 MAPK9 http://www.ncbi.nlm.nih.gov/gene/?term=5601 "JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016716 56034 PDGFC http://www.ncbi.nlm.nih.gov/gene/?term=56034 "FALLOTEIN, SCDGF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016717 5603 MAPK13 http://www.ncbi.nlm.nih.gov/gene/?term=5603 "MAPK 13, MAPK-13, PRKM13, SAPK4, p38delta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016718 56040 Rplp1 http://www.ncbi.nlm.nih.gov/gene/?term=56040 "2410042H16Rik, Arpp1, C430017H15Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016719 56041 Uso1 http://www.ncbi.nlm.nih.gov/gene/?term=56041 "115kDa, TAP, Vdp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016720 56043 Akr1e1 http://www.ncbi.nlm.nih.gov/gene/?term=56043 "1810061I10Rik, Akr1e2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016721 56045 Samhd1 http://www.ncbi.nlm.nih.gov/gene/?term=56045 "E330031J07Rik, Mg11 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016722 56046 Uqcc1 http://www.ncbi.nlm.nih.gov/gene/?term=56046 "2310079L17Rik, 2410003P15Rik, 3110038N19Rik, Bfzb, Bfzp, Cbp3, Uqcc " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016723 56048 Lgals8 http://www.ncbi.nlm.nih.gov/gene/?term=56048 "1200015E08Rik, AI326142, D13Ertd524e, Lgals-8 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016724 5604 MAP2K1 http://www.ncbi.nlm.nih.gov/gene/?term=5604 "CFC3, MAPKK1, MEK1, MKK1, PRKMK1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016725 5604 MAP2K1 http://www.ncbi.nlm.nih.gov/gene/?term=5604 "CFC3, MAPKK1, MEK1, MKK1, PRKMK1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016726 56052 ALG1 http://www.ncbi.nlm.nih.gov/gene/?term=56052 "CDG1K, HMAT1, HMT-1, HMT1, MT-1, Mat-1, hMat-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016727 56057 Btg4 http://www.ncbi.nlm.nih.gov/gene/?term=56057 "C86116, PC3B " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016728 5605 MAP2K2 http://www.ncbi.nlm.nih.gov/gene/?term=5605 "CFC4, MAPKK2, MEK2, MKK2, PRKMK2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016729 5605 MAP2K2 http://www.ncbi.nlm.nih.gov/gene/?term=5605 "CFC4, MAPKK2, MEK2, MKK2, PRKMK2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016730 5605 MAP2K2 http://www.ncbi.nlm.nih.gov/gene/?term=5605 "CFC4, MAPKK2, MEK2, MKK2, PRKMK2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016731 56061 UBFD1 http://www.ncbi.nlm.nih.gov/gene/?term=56061 UBPH mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016732 56063 TMEM234 http://www.ncbi.nlm.nih.gov/gene/?term=56063 "AASL548, C1orf91, PRO1105, RP4-622L5, dJ622L5.7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016733 5606 MAP2K3 http://www.ncbi.nlm.nih.gov/gene/?term=5606 "MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016734 5606 MAP2K3 http://www.ncbi.nlm.nih.gov/gene/?term=5606 "MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016735 56075 Pdss1 http://www.ncbi.nlm.nih.gov/gene/?term=56075 "2610203G20Rik, 2700031G06Rik, TPT, TPT 1, Tprt, mDLP1, mSPS1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016736 56077 Dgke http://www.ncbi.nlm.nih.gov/gene/?term=56077 "C87606, DAGK6, DGK " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016737 56078 Car5b http://www.ncbi.nlm.nih.gov/gene/?term=56078 "7330410H16Rik, CAVB, Ca5b, CarVb, D730005F19Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016738 56078 Car5b http://www.ncbi.nlm.nih.gov/gene/?term=56078 "7330410H16Rik, CAVB, Ca5b, CarVb, D730005F19Rik " mRNA Mus musculus 20820888 Mitochondrion Gland tissue qRT-PCR "In the present study, we examined the mRNA expression of all 13 enzymatically active CA isozymes by qRT-PCR in the mouse harderian gland. As shown in Fig. 1, nine of the 13 isozymes were detected in the harderian gland tissue at the mRNA level. Four isoforms were cytosolic (Car2, Car3, Car7, and Car13), three were membrane-associated (Car4, Car12, and Car15), one was mitochondrial (Car5b), and one was secreted (Car6). " RLID00016739 5607 MAP2K5 http://www.ncbi.nlm.nih.gov/gene/?term=5607 "HsT17454, MAPKK5, MEK5, PRKMK5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016740 56086 Set http://www.ncbi.nlm.nih.gov/gene/?term=56086 "2610030F17Rik, 5730420M11Rik, AA407739, I-2PP2A, StF-IT-1, TAF-I " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016741 56095 Ftsj3 http://www.ncbi.nlm.nih.gov/gene/?term=56095 "AA537063, AU045295, C79843, D11Ertd400e, Epcs3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016742 5609 MAP2K7 http://www.ncbi.nlm.nih.gov/gene/?term=5609 "JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016743 5610 EIF2AK2 http://www.ncbi.nlm.nih.gov/gene/?term=5610 "EIF2AK1, PKR, PPP1R83, PRKR " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016744 5611 DNAJC3 http://www.ncbi.nlm.nih.gov/gene/?term=5611 "ACPHD, ERdj6, HP58, P58, P58IPK, PRKRI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016745 5611 DNAJC3 http://www.ncbi.nlm.nih.gov/gene/?term=5611 "ACPHD, ERdj6, HP58, P58, P58IPK, PRKRI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016746 56125 PCDHB11 http://www.ncbi.nlm.nih.gov/gene/?term=56125 "ME2, PCDH-BETA11 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016747 56127 PCDHB9 http://www.ncbi.nlm.nih.gov/gene/?term=56127 "PCDH-BETA9, PCDH3H " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016748 56127 PCDHB9 http://www.ncbi.nlm.nih.gov/gene/?term=56127 "PCDH-BETA9, PCDH3H " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016749 5612 THAP12 http://www.ncbi.nlm.nih.gov/gene/?term=5612 "DAP4, P52rIPK, PRKRIR, THAP0 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016750 56149 Grasp http://www.ncbi.nlm.nih.gov/gene/?term=56149 tamalin mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016751 56150 Mad2l1 http://www.ncbi.nlm.nih.gov/gene/?term=56150 "AA673185, MAD2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016752 56159 TEX11 http://www.ncbi.nlm.nih.gov/gene/?term=56159 "SPGFX2, TGC1, TSGA3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016753 56159 TEX11 http://www.ncbi.nlm.nih.gov/gene/?term=56159 "SPGFX2, TGC1, TSGA3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016754 56160 NSMCE3 http://www.ncbi.nlm.nih.gov/gene/?term=56160 "HCA4, MAGEG1, MAGEL3, NDNL2, NSE3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016755 56160 NSMCE3 http://www.ncbi.nlm.nih.gov/gene/?term=56160 "HCA4, MAGEG1, MAGEL3, NDNL2, NSE3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016756 56172 ANKH http://www.ncbi.nlm.nih.gov/gene/?term=56172 "ANK, CCAL2, CMDJ, CPPDD, HANK, MANK " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016757 56172 ANKH http://www.ncbi.nlm.nih.gov/gene/?term=56172 "ANK, CCAL2, CMDJ, CPPDD, HANK, MANK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016758 56172 ANKH http://www.ncbi.nlm.nih.gov/gene/?term=56172 "ANK, CCAL2, CMDJ, CPPDD, HANK, MANK " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016759 56174 Nagk http://www.ncbi.nlm.nih.gov/gene/?term=56174 Gnk mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016760 56177 Olfm1 http://www.ncbi.nlm.nih.gov/gene/?term=56177 "AMY, AW742568, Noe1, OlfA, Pancortin, Pancortin3 " mRNA Mus musculus 25301173 Dendrite Hippocampus In situ hybridization "Figure 2: In situ hybridization reveals species-specific patterns of localization in neuronal dendrites. Fluorescent Microscopy evaluation of biotin-conjugated oligoprobes on paraformaldehyde fixed 14-day cultured rat and mouse cortical neurons hybridized with nine biotin-conjugated oligoprobes detected with streptadivin-Alexa Fluor 568 (Invitrogen). For each probe images set, the small bottom left corner panels represent MAP2 immuno-staining. Scale bar = 20um. (A), Probes against SFRS16, ARHGDIA and HNRPK transcripts show higher dendritic localization in mouse neurons than in rat neurons (Red box). (B), Probes against ZFP410, COMMD3 and RSP6 transcripts show higher dendritic localization in rat neurons than in mouse neurons (Blue box). (C), Probes against UBA52, OLFM1 and H2AFZ transcripts show high dendritic localization in both rat and mouse neurons (Black box). Data are collected from Figure 2. " RLID00016761 5617 PRL http://www.ncbi.nlm.nih.gov/gene/?term=5617 GHA1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016762 56180 MOSPD1 http://www.ncbi.nlm.nih.gov/gene/?term=56180 DJ473B4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016763 56181 MTFR1L http://www.ncbi.nlm.nih.gov/gene/?term=56181 "FAM54B, HYST1888, MST116, MSTP116 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016764 5618 PRLR http://www.ncbi.nlm.nih.gov/gene/?term=5618 "HPRL, MFAB, hPRLrI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016765 56190 Rbm38 http://www.ncbi.nlm.nih.gov/gene/?term=56190 "Rnpc1, Seb4, Seb4l " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016766 56191 Tro http://www.ncbi.nlm.nih.gov/gene/?term=56191 "AA409408, Maged3, Maged3l, Tnnl, magphinin, Tro " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016767 56193 Plek http://www.ncbi.nlm.nih.gov/gene/?term=56193 2010300B13Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016768 56194 Prpf40a http://www.ncbi.nlm.nih.gov/gene/?term=56194 "2810012K09Rik, FBP11, Fnbp11, Fnbp3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016769 56195 Ptbp2 http://www.ncbi.nlm.nih.gov/gene/?term=56195 "Ptb2, brPTB, nPTB " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016770 56196 Tdp2 http://www.ncbi.nlm.nih.gov/gene/?term=56196 "D13Ertd656e, Ttrap " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016771 56200 Ddx21 http://www.ncbi.nlm.nih.gov/gene/?term=56200 "AI255159, AL022742, D10Ertd645e, D10Wsu42e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016772 56204 FAM214A http://www.ncbi.nlm.nih.gov/gene/?term=56204 KIAA1370 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016773 56207 Uchl5 http://www.ncbi.nlm.nih.gov/gene/?term=56207 "5830413B11Rik, Uch37 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016774 56208 Becn1 http://www.ncbi.nlm.nih.gov/gene/?term=56208 "4921513J16Rik, 5430417M23Rik, Atg6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016775 56210 Rev1 http://www.ncbi.nlm.nih.gov/gene/?term=56210 "1110027I23Rik, AU022044l, Rev1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016776 5621 PRNP http://www.ncbi.nlm.nih.gov/gene/?term=5621 "ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016777 56241 SUSD2 http://www.ncbi.nlm.nih.gov/gene/?term=56241 BK65A6.2 mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00016778 56248 Ak3 http://www.ncbi.nlm.nih.gov/gene/?term=56248 "AA407498, AI506714, AK-3l, Ak3l1, Akl3l, Ak3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016779 56252 YLPM1 http://www.ncbi.nlm.nih.gov/gene/?term=56252 "C14orf170, PPP1R169, ZAP113, ZAP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016780 56255 TMX4 http://www.ncbi.nlm.nih.gov/gene/?term=56255 "DJ971N18.2, PDIA14, TXNDC13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016781 56255 TMX4 http://www.ncbi.nlm.nih.gov/gene/?term=56255 "DJ971N18.2, PDIA14, TXNDC13 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016782 56258 Hnrnph2 http://www.ncbi.nlm.nih.gov/gene/?term=56258 "DXHXS1271E, Ftp-3, Ftp3, H', HNRNP, Hnrph2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016783 56259 CTNNBL1 http://www.ncbi.nlm.nih.gov/gene/?term=56259 "C20orf33, NAP, P14L, PP8304, dJ633O20.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016784 56261 GPCPD1 http://www.ncbi.nlm.nih.gov/gene/?term=56261 "EDI3, GDE5, GDPD6, PREI4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016785 56262 LRRC8A http://www.ncbi.nlm.nih.gov/gene/?term=56262 "AGM5, LRRC8, SWELL1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016786 56264 Cpxm1 http://www.ncbi.nlm.nih.gov/gene/?term=56264 "AA986902, Cpx-1, Cpx1, Cpxm " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016787 56267 CCBL2 http://www.ncbi.nlm.nih.gov/gene/?term=56267 "KAT3, KATIII " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016788 56267 KYAT3 http://www.ncbi.nlm.nih.gov/gene/?term=56267 "KAT3, KATIII " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016789 56270 WDR45B http://www.ncbi.nlm.nih.gov/gene/?term=56270 "WDR45L, WIPI-3, WIPI3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016790 56270 WDR45B http://www.ncbi.nlm.nih.gov/gene/?term=56270 "WDR45L, WIPI-3, WIPI3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016791 56273 Pex14 http://www.ncbi.nlm.nih.gov/gene/?term=56273 "Pex14p, R75137 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016792 56274 Stk3 http://www.ncbi.nlm.nih.gov/gene/?term=56274 "0610042I06Rik, MST, Mst2, Mst3, Ste20, mess1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016793 56274 Stk3 http://www.ncbi.nlm.nih.gov/gene/?term=56274 "0610042I06Rik, MST, Mst2, Mst3, Ste20, mess1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016794 56278 Gkap1 http://www.ncbi.nlm.nih.gov/gene/?term=56278 "42kDa, 4933400B15Rik, D13Ertd340e, Gkap42 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016795 5627 PROS1 http://www.ncbi.nlm.nih.gov/gene/?term=5627 "PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016796 5627 PROS1 http://www.ncbi.nlm.nih.gov/gene/?term=5627 "PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016797 56280 Mrpl37 http://www.ncbi.nlm.nih.gov/gene/?term=56280 "2300004O14Rik, AI132596, MRP-L2, Rpml2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016798 56282 Mrpl12 http://www.ncbi.nlm.nih.gov/gene/?term=56282 "0610034O11Rik, 1500031N16Rik, MRP-L12, Rpml12 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016799 56288 PARD3 http://www.ncbi.nlm.nih.gov/gene/?term=56288 "ASIP, Baz, PAR3, PAR3alpha, PARD-3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, PARD3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016800 56288 PARD3 http://www.ncbi.nlm.nih.gov/gene/?term=56288 "ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016801 56295 Higd1a http://www.ncbi.nlm.nih.gov/gene/?term=56295 "2210020B17Rik, 7420700H20Rik, AI303276, AW049839, HIMP1, Hig1 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00016802 56298 Atl2 http://www.ncbi.nlm.nih.gov/gene/?term=56298 "2010110I21Rik, AA407293, AV334690, Aip-2, Arl6ip2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016803 56306 Fam60a http://www.ncbi.nlm.nih.gov/gene/?term=56306 "Ppcs1, Pptcs1, Tera " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016804 56307 Metap2 http://www.ncbi.nlm.nih.gov/gene/?term=56307 "4930584B20Rik, A930035J23Rik, AI047573, AL024412, AU014659, Amp2, Mnpep, p67, p67eIF2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016805 56314 Zfp113 http://www.ncbi.nlm.nih.gov/gene/?term=56314 "4732456B05Rik, mKIAA4229 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016806 56316 Ggcx http://www.ncbi.nlm.nih.gov/gene/?term=56316 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016807 56317 Anapc7 http://www.ncbi.nlm.nih.gov/gene/?term=56317 "APC7, AW545589 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016808 5631 PRPS1 http://www.ncbi.nlm.nih.gov/gene/?term=5631 "ARTS, CMTX5, DFN2, DFNX1, PPRibP, PRS-I, PRSI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016809 56325 Abcb9 http://www.ncbi.nlm.nih.gov/gene/?term=56325 "TAPL, mKIAA1520 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016810 56327 Arl2 http://www.ncbi.nlm.nih.gov/gene/?term=56327 "2610009M23Rik, AI115441, AW553335 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016811 56327 Arl2 http://www.ncbi.nlm.nih.gov/gene/?term=56327 "2610009M23Rik, AI115441, AW553335 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016812 56334 Tmed2 http://www.ncbi.nlm.nih.gov/gene/?term=56334 "1110032D12Rik, 1810020N21Rik, Rnp24, Sid394, p24beta1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016813 56338 Txnip http://www.ncbi.nlm.nih.gov/gene/?term=56338 "1200008J08Rik, AA682105, Hyplip1, THIF, Tbp-2, VDUP1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016814 56339 METTL3 http://www.ncbi.nlm.nih.gov/gene/?term=56339 "IME4, M6A, MT-A70, Spo8 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016815 56348 Hsd17b12 http://www.ncbi.nlm.nih.gov/gene/?term=56348 "2610510O05Rik, AI172963, KIK-I, Kik1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016816 5634 PRPS2 http://www.ncbi.nlm.nih.gov/gene/?term=5634 PRSII mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016817 5634 PRPS2 http://www.ncbi.nlm.nih.gov/gene/?term=5634 PRSII mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016818 56350 Arl3 http://www.ncbi.nlm.nih.gov/gene/?term=56350 mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00016819 56351 Ptges3 http://www.ncbi.nlm.nih.gov/gene/?term=56351 "5730442A20Rik, Ptges, Tebp, cPGES, p23, sid3177 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016820 56356 Gltp http://www.ncbi.nlm.nih.gov/gene/?term=56356 "1110001F24Rik, C76925, C77564 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016821 56357 Ivd http://www.ncbi.nlm.nih.gov/gene/?term=56357 "1300016K07Rik, 6720455E18Rik, AI463340 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016822 5635 PRPSAP1 http://www.ncbi.nlm.nih.gov/gene/?term=5635 PAP39 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016823 5635 PRPSAP1 http://www.ncbi.nlm.nih.gov/gene/?term=5635 PAP39 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016824 56362 Sult1b1 http://www.ncbi.nlm.nih.gov/gene/?term=56362 "ST1B1, St2b2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016825 56363 Tmeff2 http://www.ncbi.nlm.nih.gov/gene/?term=56363 "4832418D20Rik, 7630402F16Rik, TR-2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016826 56363 Tmeff2 http://www.ncbi.nlm.nih.gov/gene/?term=56363 "4832418D20Rik, 7630402F16Rik, TR-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016827 5636 PRPSAP2 http://www.ncbi.nlm.nih.gov/gene/?term=5636 PAP41 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016828 56370 Tagln3 http://www.ncbi.nlm.nih.gov/gene/?term=56370 "2700038H05Rik, 2900005O10Rik, AI426007, Np25 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016829 56371 Fzr1 http://www.ncbi.nlm.nih.gov/gene/?term=56371 "AW108046, Cdh1, FZR, FZR2, Fyr, HCDH, HCDH1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016830 56374 Tmem59 http://www.ncbi.nlm.nih.gov/gene/?term=56374 "1110001M20Rik, 3110046P06Rik, AI256529, D4Ertd20e, MTDCF1, ORF18 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016831 56375 B4galt4 http://www.ncbi.nlm.nih.gov/gene/?term=56375 "9130402O08Rik, B4galt-IV, b4Gal-T4, beta4Gal-T4, beta4GalT-IV " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016832 56376 Pdlim5 http://www.ncbi.nlm.nih.gov/gene/?term=56376 "1110001A05Rik, AI987914, C87059, Enh, Enh1, Enh2, Enh3, LIM " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016833 56381 Spen http://www.ncbi.nlm.nih.gov/gene/?term=56381 "Mint, mKIAA0929 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016834 56381 Spen http://www.ncbi.nlm.nih.gov/gene/?term=56381 "Mint, mKIAA0929 " mRNA Mus musculus 26190105 Nucleus Embryotem cell Microscopy "Figure 6: 3DSIM Showing that Xist RNA, Rbm15, Wtap, and Spen Co-localize within Perichromatin Spaces. Data are collected from Figure 6. " RLID00016835 5638 PRRG1 http://www.ncbi.nlm.nih.gov/gene/?term=5638 PRGP1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016836 5638 PRRG1 http://www.ncbi.nlm.nih.gov/gene/?term=5638 PRGP1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016837 56392 Shoc2 http://www.ncbi.nlm.nih.gov/gene/?term=56392 "AU017287, Sur8, mKIAA0862 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016838 56397 Morf4l2 http://www.ncbi.nlm.nih.gov/gene/?term=56397 "2410017O14Rik, Mrgx, Sid393p, mKIAA0026 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016839 56399 Akap8 http://www.ncbi.nlm.nih.gov/gene/?term=56399 "1200016A02Rik, AA673585, AKAP-8, AKAP95, AU015639 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016840 5639 PRRG2 http://www.ncbi.nlm.nih.gov/gene/?term=5639 PRGP2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016841 5639 PRRG2 http://www.ncbi.nlm.nih.gov/gene/?term=5639 PRGP2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016842 56403 Syncrip http://www.ncbi.nlm.nih.gov/gene/?term=56403 "2610109K23Rik, 4632417O19Rik, GRY-RBP, Nsap1, Nsap1l, pp68 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016843 56404 Trip4 http://www.ncbi.nlm.nih.gov/gene/?term=56404 "4930558E03Rik, ASC-1, Asc1, BB191711 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016844 56406 Ncoa6 http://www.ncbi.nlm.nih.gov/gene/?term=56406 "AIB3, ASC-2, ASC2, NRC, Ncoa7, PRIP, RAP250, mKIAA0181 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016845 56417 Adar http://www.ncbi.nlm.nih.gov/gene/?term=56417 "AV2424511, Adar1p110, Adar1p150, mZaADAR, Adar " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016846 56419 Diaph3 http://www.ncbi.nlm.nih.gov/gene/?term=56419 "4930417P13Rik, Dia2, Diap3, Drf3, mDia2, mKIAA4117, p134MDia2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016847 5641 LGMN http://www.ncbi.nlm.nih.gov/gene/?term=5641 "AEP1, PRSC1, LGMN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016848 5641 LGMN http://www.ncbi.nlm.nih.gov/gene/?term=5641 "AEP1, PRSC1, LGMN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016849 5641 LGMN http://www.ncbi.nlm.nih.gov/gene/?term=5641 "AEP1, PRSC1, LGMN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016850 5641 LGMN http://www.ncbi.nlm.nih.gov/gene/?term=5641 "AEP, LGMN1, PRSC1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016851 56420 Ppp4c http://www.ncbi.nlm.nih.gov/gene/?term=56420 "1110002D08Rik, AU016079, Ppx " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016852 56421 Pfkp http://www.ncbi.nlm.nih.gov/gene/?term=56421 "1200015H23Rik, 9330125N24Rik, ATP-PFK, PFK-C, PFK-P " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00016853 56422 Hbs1l http://www.ncbi.nlm.nih.gov/gene/?term=56422 "2810035F15Rik, AI326327, eRFS " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016854 56431 Dstn http://www.ncbi.nlm.nih.gov/gene/?term=56431 "2610043P17Rik, ADF, AU042046, Dsn, corn1, sid23p " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016855 56434 Tspan3 http://www.ncbi.nlm.nih.gov/gene/?term=56434 "1700055K04Rik, TM4-A, Tm4sf8 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016856 56434 Tspan3 http://www.ncbi.nlm.nih.gov/gene/?term=56434 "1700055K04Rik, TM4-A, Tm4sf8 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016857 56441 Nat6 http://www.ncbi.nlm.nih.gov/gene/?term=56441 "AI225910, Fus2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016858 56442 Serinc1 http://www.ncbi.nlm.nih.gov/gene/?term=56442 "1500011D18Rik, AI315070, AIGP-2, TMS-2, Tde1l, Tde2, Tms2, mKIAA1253 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016859 56445 Dnaja2 http://www.ncbi.nlm.nih.gov/gene/?term=56445 "1500017M13Rik, 2010206B19Rik, DNAJ, DNJ3, Dnaj3, HIRIP4, PRO3015, mDj3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016860 56447 Copz1 http://www.ncbi.nlm.nih.gov/gene/?term=56447 "5930435A22Rik, AA407760, D4Ertd360e " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016861 5644 PRSS1 http://www.ncbi.nlm.nih.gov/gene/?term=5644 "TRP1, TRY1, TRY4, TRYP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016862 56453 Mbtps1 http://www.ncbi.nlm.nih.gov/gene/?term=56453 "0610038M03Rik, AV003995, S1P, SKI-1, Ski1, mKIAA0091 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016863 56455 Dynll1 http://www.ncbi.nlm.nih.gov/gene/?term=56455 "Dlc8, Dnclc1, Pin " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016864 56469 Pias1 http://www.ncbi.nlm.nih.gov/gene/?term=56469 "2900068C24Rik, Ddxbp1, GBP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016865 5646 PRSS3 http://www.ncbi.nlm.nih.gov/gene/?term=5646 "MTG, PRSS4, T9, TRY3, TRY4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016866 56490 Zbtb20 http://www.ncbi.nlm.nih.gov/gene/?term=56490 "1300017A20Rik, 7330412A13Rik, A930017C21Rik, D16Wsu73e, DPZF, HOF, ODA-8S, Oda8, Zfp288 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016867 56495 Asna1 http://www.ncbi.nlm.nih.gov/gene/?term=56495 "1810048H22Rik, ArsA " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016868 56496 Tspan6 http://www.ncbi.nlm.nih.gov/gene/?term=56496 "6720473L21Rik, AI316786, T245, TSPAN-6, Tm4sf, Tm4sf6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016869 5649 RELN http://www.ncbi.nlm.nih.gov/gene/?term=5649 "ETL7, LIS2, PRO1598, RL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016870 56504 Srpk3 http://www.ncbi.nlm.nih.gov/gene/?term=56504 "Mssk1, Stk23 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016871 56513 Pard6a http://www.ncbi.nlm.nih.gov/gene/?term=56513 "0710008C04Rik, 2610010A15Rik, PAR-6A, PAR6alpha, Par-6, Par6, Par6c, TAX40, Tip-40 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016872 56516 Rbms2 http://www.ncbi.nlm.nih.gov/gene/?term=56516 "2610315E04Rik, Scr3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016873 56520 Nme4 http://www.ncbi.nlm.nih.gov/gene/?term=56520 "2610027N22Rik, 2810024O08Rik, 5730493H09Rik, NM23-M4, Nm23M4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016874 56521 DNAJC12 http://www.ncbi.nlm.nih.gov/gene/?term=56521 JDP1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016875 56529 Sec11a http://www.ncbi.nlm.nih.gov/gene/?term=56529 "1810012E07Rik, 18kDa, Sec11l1, Sid2895p, Spc18, sid2895 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016876 5652 PRSS8 http://www.ncbi.nlm.nih.gov/gene/?term=5652 "CAP1, PROSTASIN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016877 5652 PRSS8 http://www.ncbi.nlm.nih.gov/gene/?term=5652 "CAP1, PROSTASIN " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016878 56530 Cnpy2 http://www.ncbi.nlm.nih.gov/gene/?term=56530 "5330432A10Rik, AW229003, D10Bwg1546e, Tmem4, Zsig9 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016879 56531 Ylpm1 http://www.ncbi.nlm.nih.gov/gene/?term=56531 "A930013E17Rik, ZAP, Zap3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016880 56535 Pex3 http://www.ncbi.nlm.nih.gov/gene/?term=56535 "1700014F15Rik, 2810027F19Rik, 2900010N04Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016881 56541 Habp4 http://www.ncbi.nlm.nih.gov/gene/?term=56541 "4933413D03Rik, 4933428J01Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016882 56548 CHST7 http://www.ncbi.nlm.nih.gov/gene/?term=56548 "C6ST-2, GST-5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016883 5654 HTRA1 http://www.ncbi.nlm.nih.gov/gene/?term=5654 "ARMD7, CADASIL2, CARASIL, HtrA, L56, ORF480, PRSS11 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016884 5654 HTRA1 http://www.ncbi.nlm.nih.gov/gene/?term=5654 "ARMD7, CADASIL2, CARASIL, HtrA, L56, ORF480, PRSS11 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016885 5654 HTRA1 http://www.ncbi.nlm.nih.gov/gene/?term=5654 "ARMD7, CADASIL2, CARASIL, HtrA, L56, ORF480, PRSS11 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016886 56550 Ube2d2a http://www.ncbi.nlm.nih.gov/gene/?term=56550 "1500034D03Rik, Ubc2e, Ube2d2, ubc4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016887 56552 Vmn2r26 http://www.ncbi.nlm.nih.gov/gene/?term=56552 "V2R1, V2r1b " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016888 5655 KLK10 http://www.ncbi.nlm.nih.gov/gene/?term=5655 "NES1, PRSSL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016889 56605 ERO1B http://www.ncbi.nlm.nih.gov/gene/?term=56605 "ERO1LB, Ero1beta " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016890 5660 PSAP http://www.ncbi.nlm.nih.gov/gene/?term=5660 "GLBA, SAP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016891 5660 PSAP http://www.ncbi.nlm.nih.gov/gene/?term=5660 "GLBA, SAP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016892 5660 PSAP http://www.ncbi.nlm.nih.gov/gene/?term=5660 "GLBA, SAP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016893 56611 Anxa2 http://www.ncbi.nlm.nih.gov/gene/?term=56611 ANX2 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00016894 56622 Adam21 http://www.ncbi.nlm.nih.gov/gene/?term=56622 Adam31 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016895 56623 INPP5E http://www.ncbi.nlm.nih.gov/gene/?term=56623 "CORS1, CPD4, JBTS1, MORMS, PPI5PIV " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016896 56626 Poll http://www.ncbi.nlm.nih.gov/gene/?term=56626 "1110003P06Rik, AV007317 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016897 56632 Sphk2 http://www.ncbi.nlm.nih.gov/gene/?term=56632 C76851 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016898 56637 Gsk3b http://www.ncbi.nlm.nih.gov/gene/?term=56637 "7330414F15Rik, 8430431H08Rik, C86142, GSK-3, GSK-3beta, GSK3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016899 5663 PSEN1 http://www.ncbi.nlm.nih.gov/gene/?term=5663 "AD3, FAD, PS-1, PS1, S182 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016900 5663 PSEN1 http://www.ncbi.nlm.nih.gov/gene/?term=5663 "AD3, FAD, PS-1, PS1, S182 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016901 5663 PSEN1 http://www.ncbi.nlm.nih.gov/gene/?term=5663 "AD3, FAD, PS-1, PS1, S182 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016902 56644 Clec7a http://www.ncbi.nlm.nih.gov/gene/?term=56644 "BGR, Clecsf12, beta-GR " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016903 56647 BCCIP http://www.ncbi.nlm.nih.gov/gene/?term=56647 "TOK-1, TOK1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016904 56647 BCCIP http://www.ncbi.nlm.nih.gov/gene/?term=56647 "TOK-1, TOK1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016905 56648 EIF5A2 http://www.ncbi.nlm.nih.gov/gene/?term=56648 "EIF-5A2, eIF5AII " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016906 56648 EIF5A2 http://www.ncbi.nlm.nih.gov/gene/?term=56648 "EIF-5A2, eIF5AII " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016907 56648 EIF5A2 http://www.ncbi.nlm.nih.gov/gene/?term=56648 "EIF-5A2, eIF5AII " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016908 56649 TMPRSS4 http://www.ncbi.nlm.nih.gov/gene/?term=56649 "CAPH2, MT-SP2, TMPRSS3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016909 5664 PSEN2 http://www.ncbi.nlm.nih.gov/gene/?term=5664 "AD3L, AD4, CMD1V, PS2, STM2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016910 56650 CLDND1 http://www.ncbi.nlm.nih.gov/gene/?term=56650 "C3orf4, GENX-3745 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016911 56652 C10orf2 http://www.ncbi.nlm.nih.gov/gene/?term=56652 "ATXN8, IOSCA, MTDPS7, PEO, PEO1, PEOA3, PRLTS5, SANDO, SCA8, TWINL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016912 56654 NPDC1 http://www.ncbi.nlm.nih.gov/gene/?term=56654 "CAB, CAB-, CAB-1, CAB1, NPDC-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016913 56655 POLE4 http://www.ncbi.nlm.nih.gov/gene/?term=56655 "YHHQ1, p12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016914 56655 POLE4 http://www.ncbi.nlm.nih.gov/gene/?term=56655 "YHHQ1, p12 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016915 56666 PANX2 http://www.ncbi.nlm.nih.gov/gene/?term=56666 "PX2, hPANX2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016916 56667 MUC13 http://www.ncbi.nlm.nih.gov/gene/?term=56667 "DRCC1, MUC-13 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016917 56672 AKIP1 http://www.ncbi.nlm.nih.gov/gene/?term=56672 "BCA3, C11orf17 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016918 56672 AKIP1 http://www.ncbi.nlm.nih.gov/gene/?term=56672 "BCA3, C11orf17 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016919 56672 AKIP1 http://www.ncbi.nlm.nih.gov/gene/?term=56672 "BCA3, C11orf17 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016920 56674 TMEM9B http://www.ncbi.nlm.nih.gov/gene/?term=56674 C11orf15 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016921 56675 NRIP3 http://www.ncbi.nlm.nih.gov/gene/?term=56675 "C11orf14, NY-SAR-105 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016922 56681 SAR1A http://www.ncbi.nlm.nih.gov/gene/?term=56681 "SAR1, SARA1, Sara, masra2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016923 56690 Mlycd http://www.ncbi.nlm.nih.gov/gene/?term=56690 "AI324784, Mcd " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016924 56703 Pigo http://www.ncbi.nlm.nih.gov/gene/?term=56703 PIG-O mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016925 56704 JPH1 http://www.ncbi.nlm.nih.gov/gene/?term=56704 "CMT2K, JP-1, JP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016926 56704 JPH1 http://www.ncbi.nlm.nih.gov/gene/?term=56704 "CMT2K, JP-1, JP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016927 56706 Ccnl1 http://www.ncbi.nlm.nih.gov/gene/?term=56706 "2610030E23Rik, AU018493, Ccnl, ania-6a " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016928 56717 Mtor http://www.ncbi.nlm.nih.gov/gene/?term=56717 "2610315D21Rik, AI327068, FRAP, FRAP2, Frap1, RAFT1, RAPT1, flat " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016929 56717 Mtor http://www.ncbi.nlm.nih.gov/gene/?term=56717 "2610315D21Rik, AI327068, FRAP, FRAP2, Frap1, RAFT1, RAPT1, flat " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016930 567234 lrmp http://www.ncbi.nlm.nih.gov/gene/?term=567234 "si:dkey-172o10.2, si:dkey-172o10.4 " mRNA Danio rerio 22542100 Centrosome Zygote Whole mount in situ hybridization "Both maternal lrmp messenger RNA (mRNA) and protein are highly localized in the zygote, in a largely overlapping pattern at nuclear membranes, centrosomes, and spindles. " RLID00016931 567234 lrmp http://www.ncbi.nlm.nih.gov/gene/?term=567234 "si:dkey-172o10.2, si:dkey-172o10.4 " mRNA Danio rerio 22542100 Nucleus Zygote Whole mount in situ hybridization "Both maternal lrmp messenger RNA (mRNA) and protein are highly localized in the zygote, in a largely overlapping pattern at nuclear membranes, centrosomes, and spindles. " RLID00016932 567234 lrmp http://www.ncbi.nlm.nih.gov/gene/?term=567234 "si:dkey-172o10.2, si:dkey-172o10.4 " mRNA Danio rerio 22542100 Mitotic spindle Zygote Whole mount in situ hybridization "Both maternal lrmp messenger RNA (mRNA) and protein are highly localized in the zygote, in a largely overlapping pattern at nuclear membranes, centrosomes, and spindles. " RLID00016933 56726 Sh3bgrl http://www.ncbi.nlm.nih.gov/gene/?term=56726 1190008F14Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016934 56731 SLC2A4RG http://www.ncbi.nlm.nih.gov/gene/?term=56731 "GEF, HDBP-1, HDBP1, Si-1-2, Si-1-2-19 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016935 56736 Rnf14 http://www.ncbi.nlm.nih.gov/gene/?term=56736 "2310075C09Rik, 2610005D23Rik, AA986456, AU041447, D18Ertd188e, D7Bwg0165e, Triad2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016936 56737 Alg2 http://www.ncbi.nlm.nih.gov/gene/?term=56737 "1110018A23Rik, 1300013N08Rik, ALPG2, CDGIi, MNCb-5081 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016937 56749 Dhodh http://www.ncbi.nlm.nih.gov/gene/?term=56749 "2810417D19Rik, AI834883 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016938 56760 Clec1b http://www.ncbi.nlm.nih.gov/gene/?term=56760 "1810061I13Rik, Clec-2, Clec2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016939 56776 FMN2 http://www.ncbi.nlm.nih.gov/gene/?term=56776 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016940 56784 Ralgapa1 http://www.ncbi.nlm.nih.gov/gene/?term=56784 "2310003F20Rik, 4930400K19Rik, AI563624, GRIPE, Garnl1, Tulip1, mKIAA0884 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016941 56786 Tmem9b http://www.ncbi.nlm.nih.gov/gene/?term=56786 "2310004K06Rik, AW539847, D7H11orf15, ICRFP703B1614Q5.3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016942 56790 Supt20 http://www.ncbi.nlm.nih.gov/gene/?term=56790 "AA667204, AI450544, D3Ertd300e, Fam48ah, p38IP, Supt20 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016943 56791 Ube2l6 http://www.ncbi.nlm.nih.gov/gene/?term=56791 "2810489I21Rik, RIG-B, UBCH8, Ubce8, Ubcm8 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016944 567 B2M http://www.ncbi.nlm.nih.gov/gene/?term=567 IMD43 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016945 567 B2M http://www.ncbi.nlm.nih.gov/gene/?term=567 IMD43 mRNA Homo sapiens 25063809 Ribosome HeLa cell qRT-PCR "Last, the B2M (350-bp) and GRP94 (2300-bp) mRNAs were enriched in the BrS and BrR polysome fractions in the absence but not the presence of EDTA (Fig. 1, F and G). " RLID00016946 567 B2M http://www.ncbi.nlm.nih.gov/gene/?term=567 IMD43 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016947 567 B2M http://www.ncbi.nlm.nih.gov/gene/?term=567 IMD43 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016948 567 B2M http://www.ncbi.nlm.nih.gov/gene/?term=567 IMD43 mRNA Homo sapiens 25063809 Ribosome HeLa cell qRT-PCR Figure 1: Endoplasmic reticulum-associated mRNAs are partitioned between detergent-resistant and detergent-sensitive membrane domains. Data are collected from Figure 1. RLID00016949 567 B2M http://www.ncbi.nlm.nih.gov/gene/?term=567 IMD43 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016950 56802 Nespas http://www.ncbi.nlm.nih.gov/gene/?term=56802 "Gnas-as, Nespos " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016951 568084 grip2a http://www.ncbi.nlm.nih.gov/gene/?term=568084 "grip2l, si:ch211-150e8.7, si:ch73-250d21.1, wu:fi03h07 " mRNA Danio rerio 24967891 Vegetal Embryo In situ hybridization Grip2a mRNA is detected in the vegetal pole region of the yolk in early zygotes and cleavagestage embryos (Figure 3A-E) RLID00016952 568084 grip2a http://www.ncbi.nlm.nih.gov/gene/?term=568084 "grip2l, si:ch211-150e8.7, si:ch73-250d21.1, wu:fi03h07 " mRNA Danio rerio 26528729 Vegetal Embryo Whole mount in situ hybridization Whole mount in situ hybridization shows that grip2a and wnt8a mRNA are localized at the base of the vegetal cortex and experience an off-cen-ter shift in control (DMSO-treated) embryos RLID00016953 568084 grip2a http://www.ncbi.nlm.nih.gov/gene/?term=568084 "grip2l, si:ch211-150e8.7, si:ch73-250d21.1, wu:fi03h07 " mRNA Danio rerio 26528729 Vegetal Embryo Fluorescence in situ hybridization "FIGURE 2. Dual label FISH of pairwise comparisons of wnt8a, grip2a and dazl mRNA localization at the vegetal cortex. (A-C) dazl (green) and wnt8a (red). (D-F) grip2a (green) and dazl (red). (G-I) grip2a (green) and wnt8a (red). In all cases mRNAs localize to discrete units, which do not overlap between different RNAs. Embryos are wild type fixed at 20mpf. Panels are 2-D projections of imaged vegetal cortex samples. Scale bar in (I) represents 5mm for all images. (Color figure available online.) " RLID00016954 5681 PSKH1 http://www.ncbi.nlm.nih.gov/gene/?term=5681 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016955 5681 PSKH1 http://www.ncbi.nlm.nih.gov/gene/?term=5681 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016956 56829 ZC3HAV1 http://www.ncbi.nlm.nih.gov/gene/?term=56829 "ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016957 56829 ZC3HAV1 http://www.ncbi.nlm.nih.gov/gene/?term=56829 "ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016958 56829 ZC3HAV1 http://www.ncbi.nlm.nih.gov/gene/?term=56829 "ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016959 56829 ZC3HAV1 http://www.ncbi.nlm.nih.gov/gene/?term=56829 "ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016960 5682 PSMA1 http://www.ncbi.nlm.nih.gov/gene/?term=5682 "HC2, HEL-S-275, NU, PROS30 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016961 5682 PSMA1 http://www.ncbi.nlm.nih.gov/gene/?term=5682 "HC2, HEL-S-275, NU, PROS30 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016962 5682 PSMA1 http://www.ncbi.nlm.nih.gov/gene/?term=5682 "HC2, HEL-S-275, NU, PROS30 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016963 56832 IFNK http://www.ncbi.nlm.nih.gov/gene/?term=56832 "IFNT1, INFE1 " mRNA Mus musculus 12391192 Dendrite Monocytes qRT-PCR "Expression of the IFN-kappa mRNA was observed in resting dendritic cells and monocytes, and it was up-regulated by IFN-gamma stimulation in monocytes, while IFN-beta mRNA was minimally detectable under the same conditions. " RLID00016964 56834 GPR137 http://www.ncbi.nlm.nih.gov/gene/?term=56834 "C11orf4, GPR137A, TM7SF1L1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016965 5683 PSMA2 http://www.ncbi.nlm.nih.gov/gene/?term=5683 "HC3, MU, PMSA2, PSC2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016966 5683 PSMA2 http://www.ncbi.nlm.nih.gov/gene/?term=5683 "HC3, MU, PMSA2, PSC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016967 56844 Tssc4 http://www.ncbi.nlm.nih.gov/gene/?term=56844 "AA241958, ESTM671070 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016968 5684 PSMA3 http://www.ncbi.nlm.nih.gov/gene/?term=5684 "HC8, PSC3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016969 5684 PSMA3 http://www.ncbi.nlm.nih.gov/gene/?term=5684 "HC8, PSC3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016970 5684 PSMA3 http://www.ncbi.nlm.nih.gov/gene/?term=5684 "HC8, PSC3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016971 56851 EMC7 http://www.ncbi.nlm.nih.gov/gene/?term=56851 "C11orf3, C15orf24, HT022, ORF1-FL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016972 56852 RAD18 http://www.ncbi.nlm.nih.gov/gene/?term=56852 RNF73 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016973 56853 CELF4 http://www.ncbi.nlm.nih.gov/gene/?term=56853 "BRUNOL4, CELF-4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016974 5685 PSMA4 http://www.ncbi.nlm.nih.gov/gene/?term=5685 "HC9, HsT17706, PSC9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016975 5685 PSMA4 http://www.ncbi.nlm.nih.gov/gene/?term=5685 "HC9, HsT17706, PSC9 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016976 5685 PSMA4 http://www.ncbi.nlm.nih.gov/gene/?term=5685 "HC9, HsT17706, PSC9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016977 56868 Psg23 http://www.ncbi.nlm.nih.gov/gene/?term=56868 "1620401C02Rik, cea11 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00016978 5686 PSMA5 http://www.ncbi.nlm.nih.gov/gene/?term=5686 "PSC5, ZETA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016979 5686 PSMA5 http://www.ncbi.nlm.nih.gov/gene/?term=5686 "PSC5, ZETA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016980 5686 PSMA5 http://www.ncbi.nlm.nih.gov/gene/?term=5686 "PSC5, ZETA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016981 56878 Rbms1 http://www.ncbi.nlm.nih.gov/gene/?term=56878 "2600014B10Rik, AI255215, MSSP-1, MSSP-2, MSSP-3, YC1 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016982 56878 Rbms1 http://www.ncbi.nlm.nih.gov/gene/?term=56878 "2600014B10Rik, AI255215, MSSP-1, MSSP-2, MSSP-3, YC1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00016983 5687 PSMA6 http://www.ncbi.nlm.nih.gov/gene/?term=5687 "IOTA, PROS27, p27K " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016984 5687 PSMA6 http://www.ncbi.nlm.nih.gov/gene/?term=5687 "IOTA, PROS27, p27K " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016985 5687 PSMA6 http://www.ncbi.nlm.nih.gov/gene/?term=5687 "IOTA, PROS27, p27K " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016986 56882 CDC42SE1 http://www.ncbi.nlm.nih.gov/gene/?term=56882 "SCIP1, SPEC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016987 56882 CDC42SE1 http://www.ncbi.nlm.nih.gov/gene/?term=56882 "SCIP1, SPEC1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016988 56882 CDC42SE1 http://www.ncbi.nlm.nih.gov/gene/?term=56882 "SCIP1, SPEC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016989 56884 FSTL5 http://www.ncbi.nlm.nih.gov/gene/?term=56884 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016990 56886 UGGT1 http://www.ncbi.nlm.nih.gov/gene/?term=56886 "HUGT1, UGCGL1, UGT1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016991 56886 UGGT1 http://www.ncbi.nlm.nih.gov/gene/?term=56886 "HUGT1, UGCGL1, UGT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016992 56888 KCMF1 http://www.ncbi.nlm.nih.gov/gene/?term=56888 "DEBT91, FIGC, PCMF, ZZZ1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016993 56889 TM9SF3 http://www.ncbi.nlm.nih.gov/gene/?term=56889 "EP70-P-iso, SMBP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016994 56889 TM9SF3 http://www.ncbi.nlm.nih.gov/gene/?term=56889 "EP70-P-iso, SMBP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016995 5688 PSMA7 http://www.ncbi.nlm.nih.gov/gene/?term=5688 "C6, HEL-S-276, HSPC, RC6-1, XAPC7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00016996 5688 PSMA7 http://www.ncbi.nlm.nih.gov/gene/?term=5688 "C6, HEL-S-276, HSPC, RC6-1, XAPC7 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00016997 5688 PSMA7 http://www.ncbi.nlm.nih.gov/gene/?term=5688 "C6, HEL-S-276, HSPC, RC6-1, XAPC7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00016998 56890 MDM1 http://www.ncbi.nlm.nih.gov/gene/?term=56890 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00016999 56890 MDM1 http://www.ncbi.nlm.nih.gov/gene/?term=56890 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017000 56890 MDM1 http://www.ncbi.nlm.nih.gov/gene/?term=56890 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017001 56893 UBQLN4 http://www.ncbi.nlm.nih.gov/gene/?term=56893 "A1U, A1Up, C1orf6, CIP75, UBIN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017002 56893 UBQLN4 http://www.ncbi.nlm.nih.gov/gene/?term=56893 "A1U, A1Up, C1orf6, CIP75, UBIN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017003 56893 UBQLN4 http://www.ncbi.nlm.nih.gov/gene/?term=56893 "A1U, A1Up, C1orf6, CIP75, UBIN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017004 56894 AGPAT3 http://www.ncbi.nlm.nih.gov/gene/?term=56894 "LPAAT-GAMMA1, LPAAT3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017005 56895 AGPAT4 http://www.ncbi.nlm.nih.gov/gene/?term=56895 "1-AGPAT4, LPAAT-delta, dJ473J16.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017006 56896 DPYSL5 http://www.ncbi.nlm.nih.gov/gene/?term=56896 "CRAM, CRMP-5, CRMP5, Ulip6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017007 56896 DPYSL5 http://www.ncbi.nlm.nih.gov/gene/?term=56896 "CRAM, CRMP-5, CRMP5, Ulip6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017008 56896 DPYSL5 http://www.ncbi.nlm.nih.gov/gene/?term=56896 "CRAM, CRMP-5, CRMP5, Ulip6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017009 56897 WRNIP1 http://www.ncbi.nlm.nih.gov/gene/?term=56897 "WHIP, bA420G6.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017010 56897 WRNIP1 http://www.ncbi.nlm.nih.gov/gene/?term=56897 "WHIP, bA420G6.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017011 56898 BDH2 http://www.ncbi.nlm.nih.gov/gene/?term=56898 "DHRS6, EFA6R, PRO20933, SDR15C1, UCPA-OR, UNQ6308 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017012 56898 BDH2 http://www.ncbi.nlm.nih.gov/gene/?term=56898 "DHRS6, EFA6R, PRO20933, SDR15C1, UCPA-OR, UNQ6308 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017013 5689 PSMB1 http://www.ncbi.nlm.nih.gov/gene/?term=5689 "HC5, PMSB1, PSC5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017014 5689 PSMB1 http://www.ncbi.nlm.nih.gov/gene/?term=5689 "HC5, PMSB1, PSC5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017015 5689 PSMB1 http://www.ncbi.nlm.nih.gov/gene/?term=5689 "HC5, PMSB1, PSC5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017016 56900 TMEM167B http://www.ncbi.nlm.nih.gov/gene/?term=56900 "AD-020, C1orf119 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017017 56900 TMEM167B http://www.ncbi.nlm.nih.gov/gene/?term=56900 "AD-020, C1orf119 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017018 56901 NDUFA4L2 http://www.ncbi.nlm.nih.gov/gene/?term=56901 NUOMS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017019 56902 PNO1 http://www.ncbi.nlm.nih.gov/gene/?term=56902 "KHRBP1, RRP20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017020 56902 PNO1 http://www.ncbi.nlm.nih.gov/gene/?term=56902 "KHRBP1, RRP20 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017021 56905 C15orf39 http://www.ncbi.nlm.nih.gov/gene/?term=56905 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017022 56907 SPIRE1 http://www.ncbi.nlm.nih.gov/gene/?term=56907 Spir-1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017023 56907 SPIRE1 http://www.ncbi.nlm.nih.gov/gene/?term=56907 Spir-1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017024 56907 SPIRE1 http://www.ncbi.nlm.nih.gov/gene/?term=56907 Spir-1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017025 5690 PSMB2 http://www.ncbi.nlm.nih.gov/gene/?term=5690 HC7-I mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017026 5690 PSMB2 http://www.ncbi.nlm.nih.gov/gene/?term=5690 HC7-I mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017027 5690 PSMB2 http://www.ncbi.nlm.nih.gov/gene/?term=5690 HC7-I mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017028 56910 STARD7 http://www.ncbi.nlm.nih.gov/gene/?term=56910 GTT1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017029 56912 IFT46 http://www.ncbi.nlm.nih.gov/gene/?term=56912 "C11orf2, C11orf60, CFAP32 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017030 56912 IFT46 http://www.ncbi.nlm.nih.gov/gene/?term=56912 "C11orf2, C11orf60, CFAP32 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017031 56913 C1GALT1 http://www.ncbi.nlm.nih.gov/gene/?term=56913 "C1GALT, T-synthase " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017032 56915 EXOSC5 http://www.ncbi.nlm.nih.gov/gene/?term=56915 "RRP41B, RRP46, Rrp46p, hRrp46p, p12B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017033 56916 SMARCAD1 http://www.ncbi.nlm.nih.gov/gene/?term=56916 "ADERM, ETL1, HEL1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017034 56916 SMARCAD1 http://www.ncbi.nlm.nih.gov/gene/?term=56916 "ADERM, ETL1, HEL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017035 56918 C2orf83 http://www.ncbi.nlm.nih.gov/gene/?term=56918 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017036 56918 C2orf83 http://www.ncbi.nlm.nih.gov/gene/?term=56918 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017037 56919 DHX33 http://www.ncbi.nlm.nih.gov/gene/?term=56919 DDX33 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017038 5691 PSMB3 http://www.ncbi.nlm.nih.gov/gene/?term=5691 HC10-II mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017039 5691 PSMB3 http://www.ncbi.nlm.nih.gov/gene/?term=5691 HC10-II mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017040 56924 PAK6 http://www.ncbi.nlm.nih.gov/gene/?term=56924 PAK5 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017041 56926 NCLN http://www.ncbi.nlm.nih.gov/gene/?term=56926 NET59 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017042 56927 GPR108 http://www.ncbi.nlm.nih.gov/gene/?term=56927 LUSTR2 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017043 56927 GPR108 http://www.ncbi.nlm.nih.gov/gene/?term=56927 LUSTR2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017044 56928 SPPL2B http://www.ncbi.nlm.nih.gov/gene/?term=56928 "IMP-4, IMP4, PSH4, PSL1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017045 56929 FEM1C http://www.ncbi.nlm.nih.gov/gene/?term=56929 "EUROIMAGE686608, EUROIMAGE783647, FEM1A " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017046 5692 PSMB4 http://www.ncbi.nlm.nih.gov/gene/?term=5692 "HN3, HsN3, PROS-26, PROS26 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017047 5692 PSMB4 http://www.ncbi.nlm.nih.gov/gene/?term=5692 "HN3, HsN3, PROS-26, PROS26 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017048 56931 DUS3L http://www.ncbi.nlm.nih.gov/gene/?term=56931 DUS3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017049 56934 CA10 http://www.ncbi.nlm.nih.gov/gene/?term=56934 "CA-RPX, CARPX, HUCEP-15 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017050 56935 SMCO4 http://www.ncbi.nlm.nih.gov/gene/?term=56935 "C11orf75, FN5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017051 5693 PSMB5 http://www.ncbi.nlm.nih.gov/gene/?term=5693 "LMPX, MB1, X " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017052 5693 PSMB5 http://www.ncbi.nlm.nih.gov/gene/?term=5693 "LMPX, MB1, X " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017053 5693 PSMB5 http://www.ncbi.nlm.nih.gov/gene/?term=5693 "LMPX, MB1, X " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017054 56940 DUSP22 http://www.ncbi.nlm.nih.gov/gene/?term=56940 "JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017055 56940 DUSP22 http://www.ncbi.nlm.nih.gov/gene/?term=56940 "JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017056 56941 HMCES http://www.ncbi.nlm.nih.gov/gene/?term=56941 "C3orf37, DC12, SRAPD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017057 56942 CMC2 http://www.ncbi.nlm.nih.gov/gene/?term=56942 "2310061C15Rik, C16orf61, DC13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017058 56942 CMC2 http://www.ncbi.nlm.nih.gov/gene/?term=56942 "2310061C15Rik, C16orf61, DC13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017059 56943 ENY2 http://www.ncbi.nlm.nih.gov/gene/?term=56943 "DC6, Sus1, e(y)2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017060 56943 ENY2 http://www.ncbi.nlm.nih.gov/gene/?term=56943 "DC6, Sus1, e(y)2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017061 56945 MRPS22 http://www.ncbi.nlm.nih.gov/gene/?term=56945 "C3orf5, COXPD5, GIBT, GK002, MRP-S22, RPMS22 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017062 56946 EMSY http://www.ncbi.nlm.nih.gov/gene/?term=56946 "C11orf30, GL002 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017063 56947 MFF http://www.ncbi.nlm.nih.gov/gene/?term=56947 "C2orf33, GL004 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017064 5694 PSMB6 http://www.ncbi.nlm.nih.gov/gene/?term=5694 "DELTA, LMPY, Y " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017065 5694 PSMB6 http://www.ncbi.nlm.nih.gov/gene/?term=5694 "DELTA, LMPY, Y " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017066 5694 PSMB6 http://www.ncbi.nlm.nih.gov/gene/?term=5694 "DELTA, LMPY, Y " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017067 56950 SMYD2 http://www.ncbi.nlm.nih.gov/gene/?term=56950 "HSKM-B, KMT3C, ZMYND14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017068 56951 C5orf15 http://www.ncbi.nlm.nih.gov/gene/?term=56951 "HTGN29, KCT2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017069 56951 C5orf15 http://www.ncbi.nlm.nih.gov/gene/?term=56951 "HTGN29, KCT2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017070 56952 PRTFDC1 http://www.ncbi.nlm.nih.gov/gene/?term=56952 HHGP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017071 56953 NT5M http://www.ncbi.nlm.nih.gov/gene/?term=56953 "dNT-2, dNT2, mdN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017072 56954 NIT2 http://www.ncbi.nlm.nih.gov/gene/?term=56954 HEL-S-8a mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017073 56954 NIT2 http://www.ncbi.nlm.nih.gov/gene/?term=56954 HEL-S-8a mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017074 56954 NIT2 http://www.ncbi.nlm.nih.gov/gene/?term=56954 HEL-S-8a mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017075 5695 PSMB7 http://www.ncbi.nlm.nih.gov/gene/?term=5695 Z mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017076 5695 PSMB7 http://www.ncbi.nlm.nih.gov/gene/?term=5695 Z mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017077 5695 PSMB7 http://www.ncbi.nlm.nih.gov/gene/?term=5695 Z mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017078 56965 PARP6 http://www.ncbi.nlm.nih.gov/gene/?term=56965 "ARTD17, PARP-6-B1, PARP-6-C, pART17 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017079 5696 PSMB8 http://www.ncbi.nlm.nih.gov/gene/?term=5696 "ALDD, D6S216, D6S216E, JMP, LMP7, NKJO, PSMB5i, RING10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017080 56971 CEACAM19 http://www.ncbi.nlm.nih.gov/gene/?term=56971 CEAL1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017081 56975 FAM20C http://www.ncbi.nlm.nih.gov/gene/?term=56975 "DMP-4, DMP4, GEF-CK, RNS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017082 56983 POGLUT1 http://www.ncbi.nlm.nih.gov/gene/?term=56983 "C3orf9, CLP46, KDELCL1, KTELC1, MDS010, MDSRP, Rumi, hCLP46 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017083 56984 PSMG2 http://www.ncbi.nlm.nih.gov/gene/?term=56984 "CLAST3, HCCA3, HsT1707, MDS003, PAC2, TNFSF5IP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017084 56985 ADPRM http://www.ncbi.nlm.nih.gov/gene/?term=56985 "C17orf48, MDS006, NBLA03831 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017085 56986 DTWD1 http://www.ncbi.nlm.nih.gov/gene/?term=56986 MDS009 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017086 56987 BBX http://www.ncbi.nlm.nih.gov/gene/?term=56987 "ARTC1, HBP2, HSPC339, MDS001 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017087 56987 BBX http://www.ncbi.nlm.nih.gov/gene/?term=56987 "ARTC1, HBP2, HSPC339, MDS001 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017088 5698 PSMB9 http://www.ncbi.nlm.nih.gov/gene/?term=5698 "LMP2, PSMB6i, RING12, beta1i " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017089 56990 CDC42SE2 http://www.ncbi.nlm.nih.gov/gene/?term=56990 SPEC2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017090 56990 CDC42SE2 http://www.ncbi.nlm.nih.gov/gene/?term=56990 SPEC2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017091 56992 KIF15 http://www.ncbi.nlm.nih.gov/gene/?term=56992 "HKLP2, KNSL7, NY-BR-62 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017092 56993 TOMM22 http://www.ncbi.nlm.nih.gov/gene/?term=56993 "1C9-2, MST065, MSTP065, TOM22 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017093 56994 CHPT1 http://www.ncbi.nlm.nih.gov/gene/?term=56994 "CPT, CPT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017094 56994 CHPT1 http://www.ncbi.nlm.nih.gov/gene/?term=56994 "CPT, CPT1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017095 56994 CHPT1 http://www.ncbi.nlm.nih.gov/gene/?term=56994 "CPT, CPT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017096 56995 TULP4 http://www.ncbi.nlm.nih.gov/gene/?term=56995 TUSP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017097 56995 TULP4 http://www.ncbi.nlm.nih.gov/gene/?term=56995 TUSP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017098 56996 SLC12A9 http://www.ncbi.nlm.nih.gov/gene/?term=56996 "CCC6, CIP1, WO3.3, hCCC6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017099 56997 ADCK3 http://www.ncbi.nlm.nih.gov/gene/?term=56997 "ARCA2, CABC1, COQ10D4, COQ8, SCAR9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017100 56997 ADCK3 http://www.ncbi.nlm.nih.gov/gene/?term=56997 "ARCA2, CABC1, COQ10D4, COQ8, SCAR9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017101 56998 CTNNBIP1 http://www.ncbi.nlm.nih.gov/gene/?term=56998 ICAT mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017102 56998 CTNNBIP1 http://www.ncbi.nlm.nih.gov/gene/?term=56998 ICAT mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017103 56998 CTNNBIP1 http://www.ncbi.nlm.nih.gov/gene/?term=56998 ICAT mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017104 5699 PSMB10 http://www.ncbi.nlm.nih.gov/gene/?term=5699 "LMP10, MECL1, beta2i " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017105 57001 SDHAF3 http://www.ncbi.nlm.nih.gov/gene/?term=57001 "ACN9, DC11, Sdh7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017106 57002 YAE1D1 http://www.ncbi.nlm.nih.gov/gene/?term=57002 "C7orf36, GK003 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017107 57002 YAE1D1 http://www.ncbi.nlm.nih.gov/gene/?term=57002 "C7orf36, GK003 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017108 57003 CCDC47 http://www.ncbi.nlm.nih.gov/gene/?term=57003 "GK001, MSTP041 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017109 57003 CCDC47 http://www.ncbi.nlm.nih.gov/gene/?term=57003 "GK001, MSTP041 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017110 5700 PSMC1 http://www.ncbi.nlm.nih.gov/gene/?term=5700 "P26S4, S4, p56 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017111 57017 COQ9 http://www.ncbi.nlm.nih.gov/gene/?term=57017 "C16orf49, COQ10D5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017112 57017 COQ9 http://www.ncbi.nlm.nih.gov/gene/?term=57017 "C16orf49, COQ10D5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017113 57018 CCNL1 http://www.ncbi.nlm.nih.gov/gene/?term=57018 "ANIA6A, BM-001, PRO1073, ania-6a " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017114 57018 CCNL1 http://www.ncbi.nlm.nih.gov/gene/?term=57018 "ANIA6A, BM-001, PRO1073, ania-6a " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017115 57019 CIAPIN1 http://www.ncbi.nlm.nih.gov/gene/?term=57019 "Anamorsin, DRE2, PRO0915 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017116 57019 CIAPIN1 http://www.ncbi.nlm.nih.gov/gene/?term=57019 "Anamorsin, DRE2, PRO0915 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017117 57019 CIAPIN1 http://www.ncbi.nlm.nih.gov/gene/?term=57019 "Anamorsin, DRE2, PRO0915 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017118 5701 PSMC2 http://www.ncbi.nlm.nih.gov/gene/?term=5701 "MSS1, Nbla10058, S7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017119 5701 PSMC2 http://www.ncbi.nlm.nih.gov/gene/?term=5701 "MSS1, Nbla10058, S7 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017120 5701 PSMC2 http://www.ncbi.nlm.nih.gov/gene/?term=5701 "MSS1, Nbla10058, S7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017121 57020 C16orf62 http://www.ncbi.nlm.nih.gov/gene/?term=57020 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017122 57026 PDXP http://www.ncbi.nlm.nih.gov/gene/?term=57026 "CIN, PLP, dJ37E16.5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017123 57026 PDXP http://www.ncbi.nlm.nih.gov/gene/?term=57026 "CIN, PLP, dJ37E16.5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017124 57028 Pdxp http://www.ncbi.nlm.nih.gov/gene/?term=57028 "1600027H05Rik, AB041662, PLPP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017125 5702 PSMC3 http://www.ncbi.nlm.nih.gov/gene/?term=5702 TBP1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017126 57030 SLC17A7 http://www.ncbi.nlm.nih.gov/gene/?term=57030 "BNPI, VGLUT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017127 57035 RSRP1 http://www.ncbi.nlm.nih.gov/gene/?term=57035 "C1orf63, DJ465N24.2.1, NPD014 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017128 57037 ANKMY2 http://www.ncbi.nlm.nih.gov/gene/?term=57037 ZMYND20 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017129 57038 RARS2 http://www.ncbi.nlm.nih.gov/gene/?term=57038 "ArgRS, DALRD2, PCH6, PRO1992, RARSL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017130 57038 RARS2 http://www.ncbi.nlm.nih.gov/gene/?term=57038 "ArgRS, DALRD2, PCH6, PRO1992, RARSL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017131 57045 TWSG1 http://www.ncbi.nlm.nih.gov/gene/?term=57045 TSG mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017132 57045 TWSG1 http://www.ncbi.nlm.nih.gov/gene/?term=57045 TSG mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017133 57045 TWSG1 http://www.ncbi.nlm.nih.gov/gene/?term=57045 TSG mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017134 57047 PLSCR2 http://www.ncbi.nlm.nih.gov/gene/?term=57047 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017135 5704 PSMC4 http://www.ncbi.nlm.nih.gov/gene/?term=5704 "MIP224, RPT3, S6, TBP-7, TBP7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017136 5704 PSMC4 http://www.ncbi.nlm.nih.gov/gene/?term=5704 "MIP224, RPT3, S6, TBP-7, TBP7 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017137 5704 PSMC4 http://www.ncbi.nlm.nih.gov/gene/?term=5704 "MIP224, RPT3, S6, TBP-7, TBP7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017138 57050 UTP3 http://www.ncbi.nlm.nih.gov/gene/?term=57050 "CRL1, CRLZ1, SAS10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017139 5705 PSMC5 http://www.ncbi.nlm.nih.gov/gene/?term=5705 "S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017140 57062 DDX24 http://www.ncbi.nlm.nih.gov/gene/?term=57062 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017141 57062 DDX24 http://www.ncbi.nlm.nih.gov/gene/?term=57062 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017142 57062 DDX24 http://www.ncbi.nlm.nih.gov/gene/?term=57062 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017143 5706 PSMC6 http://www.ncbi.nlm.nih.gov/gene/?term=5706 "CADP44, HEL-S-73, P44, SUG2, p42 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017144 5706 PSMC6 http://www.ncbi.nlm.nih.gov/gene/?term=5706 "CADP44, HEL-S-73, P44, SUG2, p42 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017145 5706 PSMC6 http://www.ncbi.nlm.nih.gov/gene/?term=5706 "CADP44, HEL-S-73, P44, SUG2, p42 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017146 5707 PSMD1 http://www.ncbi.nlm.nih.gov/gene/?term=5707 "P112, Rpn2, S1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017147 57082 CASC5 http://www.ncbi.nlm.nih.gov/gene/?term=57082 "AF15Q14, CT29, D40, KNL1, PPP1R55, Spc7, hKNL-1, hSpc105 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017148 57085 AGTRAP http://www.ncbi.nlm.nih.gov/gene/?term=57085 ATRAP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017149 57085 AGTRAP http://www.ncbi.nlm.nih.gov/gene/?term=57085 ATRAP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017150 57089 ENTPD7 http://www.ncbi.nlm.nih.gov/gene/?term=57089 LALP1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017151 5708 PSMD2 http://www.ncbi.nlm.nih.gov/gene/?term=5708 "P97, RPN1, S2, TRAP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017152 5708 PSMD2 http://www.ncbi.nlm.nih.gov/gene/?term=5708 "P97, RPN1, S2, TRAP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017153 57095 PITHD1 http://www.ncbi.nlm.nih.gov/gene/?term=57095 "C1orf128, HT014, TXNL1CL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017154 57095 PITHD1 http://www.ncbi.nlm.nih.gov/gene/?term=57095 "C1orf128, HT014, TXNL1CL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017155 57099 AVEN http://www.ncbi.nlm.nih.gov/gene/?term=57099 PDCD12 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017156 57099 AVEN http://www.ncbi.nlm.nih.gov/gene/?term=57099 PDCD12 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017157 5709 PSMD3 http://www.ncbi.nlm.nih.gov/gene/?term=5709 "P58, RPN3, S3, TSTA2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017158 5709 PSMD3 http://www.ncbi.nlm.nih.gov/gene/?term=5709 "P58, RPN3, S3, TSTA2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017159 570 BAAT http://www.ncbi.nlm.nih.gov/gene/?term=570 "BACAT, BAT " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017160 57103 TIGAR http://www.ncbi.nlm.nih.gov/gene/?term=57103 "C12orf5, FR2BP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017161 57103 TIGAR http://www.ncbi.nlm.nih.gov/gene/?term=57103 "C12orf5, FR2BP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017162 57104 PNPLA2 http://www.ncbi.nlm.nih.gov/gene/?term=57104 "1110001C14Rik, ATGL, FP17548, PEDF-R, TTS-2.2, TTS2, iPLA2zeta " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017163 57104 PNPLA2 http://www.ncbi.nlm.nih.gov/gene/?term=57104 "1110001C14Rik, ATGL, FP17548, PEDF-R, TTS-2.2, TTS2, iPLA2zeta " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017164 57107 PDSS2 http://www.ncbi.nlm.nih.gov/gene/?term=57107 "C6orf210, COQ10D3, DLP1, bA59I9.3, hDLP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017165 57109 REXO4 http://www.ncbi.nlm.nih.gov/gene/?term=57109 "REX4, XPMC2, XPMC2H " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017166 5710 PSMD4 http://www.ncbi.nlm.nih.gov/gene/?term=5710 "AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017167 57110 HRASLS http://www.ncbi.nlm.nih.gov/gene/?term=57110 "A-C1, H-REV107, HRASLS1, HRSL1, HSD28 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017168 57111 RAB25 http://www.ncbi.nlm.nih.gov/gene/?term=57111 "CATX-8, RAB11C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017169 57118 CAMK1D http://www.ncbi.nlm.nih.gov/gene/?term=57118 "CKLiK, CaM-K1, CaMKID " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017170 5711 PSMD5 http://www.ncbi.nlm.nih.gov/gene/?term=5711 S5B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017171 5711 PSMD5 http://www.ncbi.nlm.nih.gov/gene/?term=5711 S5B mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017172 5711 PSMD5 http://www.ncbi.nlm.nih.gov/gene/?term=5711 S5B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017173 57120 GOPC http://www.ncbi.nlm.nih.gov/gene/?term=57120 "CAL, FIG1, PIST, dJ94G16.2, GOPC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017174 57127 RHBG http://www.ncbi.nlm.nih.gov/gene/?term=57127 SLC42A2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017175 57128 LYRM4 http://www.ncbi.nlm.nih.gov/gene/?term=57128 "C6orf149, CGI-203, COXPD19, ISD11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017176 57128 LYRM4 http://www.ncbi.nlm.nih.gov/gene/?term=57128 "C6orf149, CGI-203, COXPD19, ISD11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017177 57129 MRPL47 http://www.ncbi.nlm.nih.gov/gene/?term=57129 "CGI-204, L47mt, MRP-L47, NCM1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017178 57130 ATP13A1 http://www.ncbi.nlm.nih.gov/gene/?term=57130 "ATP13A, CGI-152 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017179 57132 CHMP1B http://www.ncbi.nlm.nih.gov/gene/?term=57132 "C10orf2, C18-ORF2, C18orf2, CHMP1.5, Vps46-2, Vps46B, hVps46-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017180 57132 CHMP1B http://www.ncbi.nlm.nih.gov/gene/?term=57132 "C10orf2, C18-ORF2, C18orf2, CHMP1.5, Vps46-2, Vps46B, hVps46-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017181 57136 APMAP http://www.ncbi.nlm.nih.gov/gene/?term=57136 "BSCv, C20orf3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017182 57136 APMAP http://www.ncbi.nlm.nih.gov/gene/?term=57136 "BSCv, C20orf3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017183 5713 PSMD7 http://www.ncbi.nlm.nih.gov/gene/?term=5713 "MOV34, P40, Rpn8, S12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017184 57142 RTN4 http://www.ncbi.nlm.nih.gov/gene/?term=57142 "ASY, NI220/250, NOGO, NOGO-A, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, Nogo-B, Nogo-C, RTN-X-A, RTN4-B1, RTN4-B2, RTN4-C, RTN4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017185 57142 RTN4 http://www.ncbi.nlm.nih.gov/gene/?term=57142 "ASY, NI220/250, NOGO, NOGO-A, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, Nogo-B, Nogo-C, RTN-X-A, RTN4-B1, RTN4-B2, RTN4-C, RTN4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017186 57146 TMEM159 http://www.ncbi.nlm.nih.gov/gene/?term=57146 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017187 57146 TMEM159 http://www.ncbi.nlm.nih.gov/gene/?term=57146 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017188 57146 TMEM159 http://www.ncbi.nlm.nih.gov/gene/?term=57146 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017189 57146 TMEM159 http://www.ncbi.nlm.nih.gov/gene/?term=57146 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017190 57148 RALGAPB http://www.ncbi.nlm.nih.gov/gene/?term=57148 "KIAA1219, RalGAPbeta " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017191 57148 RALGAPB http://www.ncbi.nlm.nih.gov/gene/?term=57148 "KIAA1219, RalGAPbeta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017192 57149 LYRM1 http://www.ncbi.nlm.nih.gov/gene/?term=57149 A211C6.1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017193 57149 LYRM1 http://www.ncbi.nlm.nih.gov/gene/?term=57149 A211C6.1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017194 5714 PSMD8 http://www.ncbi.nlm.nih.gov/gene/?term=5714 "HEL-S-91n, HIP6, HYPF, Nin1p, Rpn12, S14, p31 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017195 5714 PSMD8 http://www.ncbi.nlm.nih.gov/gene/?term=5714 "HEL-S-91n, HIP6, HYPF, Nin1p, Rpn12, S14, p31 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017196 5714 PSMD8 http://www.ncbi.nlm.nih.gov/gene/?term=5714 "HEL-S-91n, HIP6, HYPF, Nin1p, Rpn12, S14, p31 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017197 57150 SMIM8 http://www.ncbi.nlm.nih.gov/gene/?term=57150 "C6orf162, dJ102H19.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017198 57153 SLC44A2 http://www.ncbi.nlm.nih.gov/gene/?term=57153 "CTL2, PP1292 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017199 57153 SLC44A2 http://www.ncbi.nlm.nih.gov/gene/?term=57153 "CTL2, PP1292 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017200 57154 SMURF1 http://www.ncbi.nlm.nih.gov/gene/?term=57154 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017201 57154 SMURF1 http://www.ncbi.nlm.nih.gov/gene/?term=57154 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017202 57157 PHTF2 http://www.ncbi.nlm.nih.gov/gene/?term=57157 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017203 57157 PHTF2 http://www.ncbi.nlm.nih.gov/gene/?term=57157 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017204 57159 TRIM54 http://www.ncbi.nlm.nih.gov/gene/?term=57159 "MURF, MURF-3, RNF30, muRF3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017205 57159 TRIM54 http://www.ncbi.nlm.nih.gov/gene/?term=57159 "MURF, MURF-3, RNF30, muRF3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017206 57159 TRIM54 http://www.ncbi.nlm.nih.gov/gene/?term=57159 "MURF, MURF-3, RNF30, muRF3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017207 5715 PSMD9 http://www.ncbi.nlm.nih.gov/gene/?term=5715 "Rpn4, p27 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017208 5715 PSMD9 http://www.ncbi.nlm.nih.gov/gene/?term=5715 "Rpn4, p27 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017209 5715 PSMD9 http://www.ncbi.nlm.nih.gov/gene/?term=5715 "Rpn4, p27 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017210 5715 PSMD9 http://www.ncbi.nlm.nih.gov/gene/?term=5715 "Rpn4, p27 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017211 57162 PELI1 http://www.ncbi.nlm.nih.gov/gene/?term=57162 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017212 57168 ASPHD2 http://www.ncbi.nlm.nih.gov/gene/?term=57168 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017213 57169 ZNFX1 http://www.ncbi.nlm.nih.gov/gene/?term=57169 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017214 57169 ZNFX1 http://www.ncbi.nlm.nih.gov/gene/?term=57169 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017215 5716 PSMD10 http://www.ncbi.nlm.nih.gov/gene/?term=5716 "dJ889N15.2, p28, p28(GANK) " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017216 5716 PSMD10 http://www.ncbi.nlm.nih.gov/gene/?term=5716 "dJ889N15.2, p28, p28(GANK) " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017217 5716 PSMD10 http://www.ncbi.nlm.nih.gov/gene/?term=5716 "dJ889N15.2, p28, p28(GANK) " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017218 57171 DOLPP1 http://www.ncbi.nlm.nih.gov/gene/?term=57171 LSFR2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017219 57171 DOLPP1 http://www.ncbi.nlm.nih.gov/gene/?term=57171 LSFR2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017220 57171 DOLPP1 http://www.ncbi.nlm.nih.gov/gene/?term=57171 LSFR2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017221 57175 CORO1B http://www.ncbi.nlm.nih.gov/gene/?term=57175 CORONIN-2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017222 57175 CORO1B http://www.ncbi.nlm.nih.gov/gene/?term=57175 CORONIN-2 mRNA Homo sapiens 23667561 Cytosol Endothelial cell Immunocytochemistry "Furthermore, a significant fraction of coronin is also diffusely distributed within the cell cytoplasm, but this population of coronin does not co-localize with F-actin or cortactin. Upon serum starvation, coronin redistributes from the cell periphery and is distributed only within the cell cytosol (Figure 3).Furthermore, a significant fraction of coronin is also diffusely distributed within the cell cytoplasm, but this population of coronin does not co-localize with F-actin or cortactin. Upon serum starvation, coronin redistributes from the cell periphery and is distributed only within the cell cytosol (Figure 3). " RLID00017223 57175 CORO1B http://www.ncbi.nlm.nih.gov/gene/?term=57175 CORONIN-2 mRNA Homo sapiens 23667561 Lamellipodium Endothelial cell Immunocytochemistry "Coronin 1B mRNA and protein are highly expressed in human pulmonary artery, umbilical vein, aortic and lung microvascular endothelial cells (Figure 1 A & B). Under normal growth conditions, as evidenced by immunocytochemistry, coronin 1B co-localizes with F-actin in a ?2 ?M thick region at the leading edge of the cell periphery (Figure 2). This is presumably the fast “tread-milling�region of F-actin polymerization that has been well-characterized for cell lamellipodia. Furthermore, a significant fraction of coronin is also diffusely distributed within the cell cytoplasm, but this population of coronin does not co-localize with F-actin or cortactin. Upon serum starvation, coronin redistributes from the cell periphery and is distributed only within the cell cytosol (Figure 3). " RLID00017224 57176 VARS2 http://www.ncbi.nlm.nih.gov/gene/?term=57176 "COXPD20, VALRSL, VARSL, VARS2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017225 57179 KIAA1191 http://www.ncbi.nlm.nih.gov/gene/?term=57179 "p33MONOX, p60MONOX " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017226 5717 PSMD11 http://www.ncbi.nlm.nih.gov/gene/?term=5717 "Rpn6, S9, p44.5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017227 5717 PSMD11 http://www.ncbi.nlm.nih.gov/gene/?term=5717 "Rpn6, S9, p44.5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017228 57180 ACTR3B http://www.ncbi.nlm.nih.gov/gene/?term=57180 "ARP11, ARP3BETA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017229 57180 ACTR3B http://www.ncbi.nlm.nih.gov/gene/?term=57180 "ARP11, ARP3BETA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017230 57181 SLC39A10 http://www.ncbi.nlm.nih.gov/gene/?term=57181 LZT-Hs2 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017231 57181 SLC39A10 http://www.ncbi.nlm.nih.gov/gene/?term=57181 LZT-Hs2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017232 57182 ANKRD50 http://www.ncbi.nlm.nih.gov/gene/?term=57182 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017233 57184 FAM219B http://www.ncbi.nlm.nih.gov/gene/?term=57184 C15orf17 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017234 57184 FAM219B http://www.ncbi.nlm.nih.gov/gene/?term=57184 C15orf17 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017235 57184 FAM219B http://www.ncbi.nlm.nih.gov/gene/?term=57184 C15orf17 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017236 57185 NIPAL3 http://www.ncbi.nlm.nih.gov/gene/?term=57185 "DJ462O23.2, NPAL3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017237 57187 THOC2 http://www.ncbi.nlm.nih.gov/gene/?term=57187 "CXorf3, MRX12, MRX35, THO2, dJ506G2.1, hTREX120 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017238 57187 THOC2 http://www.ncbi.nlm.nih.gov/gene/?term=57187 "CXorf3, MRX12, MRX35, THO2, dJ506G2.1, hTREX120 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017239 57189 KIAA1147 http://www.ncbi.nlm.nih.gov/gene/?term=57189 "LCHN, PRO2561 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017240 5718 PSMD12 http://www.ncbi.nlm.nih.gov/gene/?term=5718 "Rpn5, p55 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017241 5718 PSMD12 http://www.ncbi.nlm.nih.gov/gene/?term=5718 "Rpn5, p55 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017242 57190 SEPN1 http://www.ncbi.nlm.nih.gov/gene/?term=57190 "CFTD, MDRS1, RSMD1, RSS, SELN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017243 57190 SEPN1 http://www.ncbi.nlm.nih.gov/gene/?term=57190 "CFTD, MDRS1, RSMD1, RSS, SELN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017244 57190 SEPN1 http://www.ncbi.nlm.nih.gov/gene/?term=57190 "CFTD, MDRS1, RSMD1, RSS, SELN " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017245 57194 ATP10A http://www.ncbi.nlm.nih.gov/gene/?term=57194 "ATP10C, ATPVA, ATPVC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017246 57194 ATP10A http://www.ncbi.nlm.nih.gov/gene/?term=57194 "ATP10C, ATPVA, ATPVC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017247 5719 PSMD13 http://www.ncbi.nlm.nih.gov/gene/?term=5719 "HSPC027, Rpn9, S11, p40.5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017248 571 BACH1 http://www.ncbi.nlm.nih.gov/gene/?term=571 "BACH-1, BTBD24 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017249 5720 PSME1 http://www.ncbi.nlm.nih.gov/gene/?term=5720 "HEL-S-129m, IFI5111, PA28A, PA28alpha, REGalpha " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017250 5720 PSME1 http://www.ncbi.nlm.nih.gov/gene/?term=5720 "HEL-S-129m, IFI5111, PA28A, PA28alpha, REGalpha " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017251 5720 PSME1 http://www.ncbi.nlm.nih.gov/gene/?term=5720 "HEL-S-129m, IFI5111, PA28A, PA28alpha, REGalpha " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017252 57210 SLC45A4 http://www.ncbi.nlm.nih.gov/gene/?term=57210 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017253 57211 ADGRG6 http://www.ncbi.nlm.nih.gov/gene/?term=57211 "APG1, DREG, GPR126, LCCS9, PS1TP2, VIGR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017254 57212 TP73-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=57212 "KIAA0495, PDAM " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017255 57212 TP73-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=57212 "KIAA0495, PDAM " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017256 57213 SPRYD7 http://www.ncbi.nlm.nih.gov/gene/?term=57213 "C13orf1, CLLD6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017257 57213 SPRYD7 http://www.ncbi.nlm.nih.gov/gene/?term=57213 "C13orf1, CLLD6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017258 57213 SPRYD7 http://www.ncbi.nlm.nih.gov/gene/?term=57213 "C13orf1, CLLD6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017259 57213 SPRYD7 http://www.ncbi.nlm.nih.gov/gene/?term=57213 "C13orf1, CLLD6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017260 57214 CEMIP http://www.ncbi.nlm.nih.gov/gene/?term=57214 "CCSP1, KIAA1199, TMEM2L " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017261 57215 THAP11 http://www.ncbi.nlm.nih.gov/gene/?term=57215 "CTG-B43a, CTG-B45d, HRIHFB2206, RONIN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017262 57215 THAP11 http://www.ncbi.nlm.nih.gov/gene/?term=57215 "CTG-B43a, CTG-B45d, HRIHFB2206, RONIN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017263 57215 THAP11 http://www.ncbi.nlm.nih.gov/gene/?term=57215 "CTG-B43a, CTG-B45d, HRIHFB2206, RONIN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017264 5721 PSME2 http://www.ncbi.nlm.nih.gov/gene/?term=5721 "PA28B, PA28beta, REGbeta " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017265 5721 PSME2 http://www.ncbi.nlm.nih.gov/gene/?term=5721 "PA28B, PA28beta, REGbeta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017266 57221 ARFGEF3 http://www.ncbi.nlm.nih.gov/gene/?term=57221 "A7322, BIG3, C6orf92, KIAA1244, PPP1R33, dJ171N11.1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017267 57222 ERGIC1 http://www.ncbi.nlm.nih.gov/gene/?term=57222 "ERGIC-32, ERGIC32, NET24 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017268 57222 ERGIC1 http://www.ncbi.nlm.nih.gov/gene/?term=57222 "ERGIC-32, ERGIC32, NET24 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017269 57222 ERGIC1 http://www.ncbi.nlm.nih.gov/gene/?term=57222 "ERGIC-32, ERGIC32, NET24 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017270 57223 PPP4R3B http://www.ncbi.nlm.nih.gov/gene/?term=57223 "FLFL2, PP4R3B, PSY2, SMEK2, smk1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017271 57223 PPP4R3B http://www.ncbi.nlm.nih.gov/gene/?term=57223 "FLFL2, PP4R3B, PSY2, SMEK2, smk1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017272 57226 LYRM2 http://www.ncbi.nlm.nih.gov/gene/?term=57226 DJ122O8.2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017273 57226 LYRM2 http://www.ncbi.nlm.nih.gov/gene/?term=57226 DJ122O8.2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017274 57228 SMAGP http://www.ncbi.nlm.nih.gov/gene/?term=57228 hSMAGP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017275 57228 SMAGP http://www.ncbi.nlm.nih.gov/gene/?term=57228 hSMAGP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017276 57231 SNX14 http://www.ncbi.nlm.nih.gov/gene/?term=57231 "RGS-PX2, SCAR20 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017277 5723 PSPH http://www.ncbi.nlm.nih.gov/gene/?term=5723 "PSPD, PSPH " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017278 5723 PSPH http://www.ncbi.nlm.nih.gov/gene/?term=5723 "PSPD, PSPH " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017279 5723 PSPH http://www.ncbi.nlm.nih.gov/gene/?term=5723 "PSP, PSPHD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017280 57246 Tbx20 http://www.ncbi.nlm.nih.gov/gene/?term=57246 "9430010M06Rik, AL022859, Tbx12 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017281 57247 Zfp276 http://www.ncbi.nlm.nih.gov/gene/?term=57247 "AW048709, D8Ertd370e, D8Ertd377e, Znf276 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017282 57258 Xpo4 http://www.ncbi.nlm.nih.gov/gene/?term=57258 "B430309A01Rik, mKIAA1721 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017283 57258 Xpo4 http://www.ncbi.nlm.nih.gov/gene/?term=57258 "B430309A01Rik, mKIAA1721 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017284 5725 PTBP1 http://www.ncbi.nlm.nih.gov/gene/?term=5725 "HNRNP-I, HNRNPI, HNRPI, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, pPTB " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017285 5725 PTBP1 http://www.ncbi.nlm.nih.gov/gene/?term=5725 "HNRNP-I, HNRNPI, HNRPI, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, pPTB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017286 57267 Apba3 http://www.ncbi.nlm.nih.gov/gene/?term=57267 "AW208791, Mint-3, X11gamma, lin-10, mint3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017287 57269 Olfr1507 http://www.ncbi.nlm.nih.gov/gene/?term=57269 "MOR244-1, Mor28, Or28 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017288 5727 PTCH1 http://www.ncbi.nlm.nih.gov/gene/?term=5727 "BCNS, HPE7, NBCCS, PTC, PTC1, PTCH, PTCH11 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017289 5728 PTEN http://www.ncbi.nlm.nih.gov/gene/?term=5728 "10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC11, TEP1, PTEN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017290 5728 PTEN http://www.ncbi.nlm.nih.gov/gene/?term=5728 "10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017291 57291 DANCR http://www.ncbi.nlm.nih.gov/gene/?term=57291 "AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR " lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017292 57291 DANCR http://www.ncbi.nlm.nih.gov/gene/?term=57291 "AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR " lncRNA Homo sapiens 25690653 Cytoplasm P493-6 cell qRT-PCR "To validate the isolation of nuclear and cytoplasmic fractions, the enrichment of 3 nuclear (ANRIL, MIAT, XIST) and 3 cytoplasmic (RPPH1, DANCR, tRNA-Lys) RNAs was analyzed by qRT-PCR. " RLID00017293 57291 DANCR http://www.ncbi.nlm.nih.gov/gene/?term=57291 "AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR " lncRNA Homo sapiens 25630241 Cytoplasm Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00017294 57291 DANCR http://www.ncbi.nlm.nih.gov/gene/?term=57291 "AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR " lncRNA Homo sapiens 25630241 Nucleus Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00017295 57294 Rps27 http://www.ncbi.nlm.nih.gov/gene/?term=57294 3200001M24Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017296 572 BAD http://www.ncbi.nlm.nih.gov/gene/?term=572 "BBC2, BCL2L8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017297 572 BAD http://www.ncbi.nlm.nih.gov/gene/?term=572 "BBC2, BCL2L8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017298 57316 C1d http://www.ncbi.nlm.nih.gov/gene/?term=57316 "1110036E10Rik, AI875855, SUN-CoR " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017299 57325 CSRP2BP http://www.ncbi.nlm.nih.gov/gene/?term=57325 "ATAC2, CRP2BP, KAT14, PRO1194, dJ717M23.1 " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00017300 57325 CSRP2BP http://www.ncbi.nlm.nih.gov/gene/?term=57325 "ATAC2, CRP2BP, KAT14, PRO1194, dJ717M23.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017301 57325 CSRP2BP http://www.ncbi.nlm.nih.gov/gene/?term=57325 "ATAC2, CRP2BP, KAT14, PRO1194, dJ717M23.1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017302 57326 PBXIP1 http://www.ncbi.nlm.nih.gov/gene/?term=57326 HPIP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017303 57332 CBX8 http://www.ncbi.nlm.nih.gov/gene/?term=57332 "PC3, RC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017304 57335 ZNF286A http://www.ncbi.nlm.nih.gov/gene/?term=57335 ZNF286 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017305 57335 ZNF286A http://www.ncbi.nlm.nih.gov/gene/?term=57335 ZNF286 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017306 57335 ZNF286A http://www.ncbi.nlm.nih.gov/gene/?term=57335 ZNF286 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017307 57337 SENP7 http://www.ncbi.nlm.nih.gov/gene/?term=57337 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017308 5733 PTGER3 http://www.ncbi.nlm.nih.gov/gene/?term=5733 "EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3-VI, EP3e, PGE2-R " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017309 57340 Jph3 http://www.ncbi.nlm.nih.gov/gene/?term=57340 "JP-3, Jp3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017310 5734 PTGER4 http://www.ncbi.nlm.nih.gov/gene/?term=5734 "EP4, EP4R " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017311 57376 Smarce1 http://www.ncbi.nlm.nih.gov/gene/?term=57376 "2810417B20Rik, 5830412H02Rik, 9030408N19Rik, Baf27 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017312 57376 Smarce1 http://www.ncbi.nlm.nih.gov/gene/?term=57376 "2810417B20Rik, 5830412H02Rik, 9030408N19Rik, Baf27 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017313 57380 MRS2 http://www.ncbi.nlm.nih.gov/gene/?term=57380 "HPTL, MRS2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017314 57380 MRS2 http://www.ncbi.nlm.nih.gov/gene/?term=57380 "HPT, MRS2L " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017315 57381 RHOJ http://www.ncbi.nlm.nih.gov/gene/?term=57381 "ARHJ, RASL7B, TC10B, TCL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017316 5738 PTGFRN http://www.ncbi.nlm.nih.gov/gene/?term=5738 "CD315, CD9P-1, EWI-F, FPRP, SMAP-6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017317 5738 PTGFRN http://www.ncbi.nlm.nih.gov/gene/?term=5738 "CD315, CD9P-1, EWI-F, FPRP, SMAP-6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017318 5738 PTGFRN http://www.ncbi.nlm.nih.gov/gene/?term=5738 "CD315, CD9P-1, EWI-F, FPRP, SMAP-6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017319 573 BAG1 http://www.ncbi.nlm.nih.gov/gene/?term=573 "BAG-1, HAP, RAP46 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017320 5740235 RhoGAP1A http://www.ncbi.nlm.nih.gov/gene/?term=5740235 "Dmel_CG40494, BCR, CG17617, CG17960, CG40453, CG40494, Dmel\CG40494, Dmel_CG00000, EG:23E12.2, EG:23E12.5, RhoGAP, rhoGAP1A " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00017321 57402 S100A14 http://www.ncbi.nlm.nih.gov/gene/?term=57402 "BCMP84, S100A15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017322 57403 RAB22A http://www.ncbi.nlm.nih.gov/gene/?term=57403 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017323 57403 RAB22A http://www.ncbi.nlm.nih.gov/gene/?term=57403 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017324 57403 RAB22A http://www.ncbi.nlm.nih.gov/gene/?term=57403 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017325 57403 RAB22A http://www.ncbi.nlm.nih.gov/gene/?term=57403 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017326 574042 SNORA10 http://www.ncbi.nlm.nih.gov/gene/?term=574042 "ACA10A, SNORA10 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00017327 574042 SNORA10 http://www.ncbi.nlm.nih.gov/gene/?term=574042 "ACA10A, SNORA10 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017328 574042 SNORA10 http://www.ncbi.nlm.nih.gov/gene/?term=574042 "ACA10A, SNORA10 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017329 57404 CYP20A1 http://www.ncbi.nlm.nih.gov/gene/?term=57404 CYP-M mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017330 57404 CYP20A1 http://www.ncbi.nlm.nih.gov/gene/?term=57404 CYP-M mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017331 57404 CYP20A1 http://www.ncbi.nlm.nih.gov/gene/?term=57404 CYP-M mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017332 5740599 pgc http://www.ncbi.nlm.nih.gov/gene/?term=5740599 "Dmel_CG32885, CG11296, CG32885, CR32885, Dmel\CG32885, Pgc, Pgc1-1, pgr, pgc " mRNA Drosophila melanogaster 26242323 Germ plasm Embryo Fluorescence in situ hybridization "Next we determined the distribution of the known germ plasm enriched mRNAs cycB, nos, pgc, gcl and oskar (osk) and one control mRNAccr4, which appears evenly distributed throughout the embryo4 (Fig. 2a,b,h). " RLID00017333 5740599 pgc http://www.ncbi.nlm.nih.gov/gene/?term=5740599 "Dmel_CG32885, CG11296, CG32885, CR32885, Dmel\CG32885, Pgc, Pgc1-1, pgr, pgc " mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00017334 5740599 pgc http://www.ncbi.nlm.nih.gov/gene/?term=5740599 "Dmel_CG32885, CG11296, CG32885, CR32885, Dmel\CG32885, Pgc, Pgc1-1, pgr, pgc " mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00017335 57406 ABHD6 http://www.ncbi.nlm.nih.gov/gene/?term=57406 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017336 57407 NMRAL1 http://www.ncbi.nlm.nih.gov/gene/?term=57407 "HSCARG, SDR48A1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017337 5740 PTGIS http://www.ncbi.nlm.nih.gov/gene/?term=5740 "CYP8, CYP8A1, PGIS, PTGI " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017338 5740 PTGIS http://www.ncbi.nlm.nih.gov/gene/?term=5740 "CYP8, CYP8A1, PGIS, PTGI " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017339 5740 PTGIS http://www.ncbi.nlm.nih.gov/gene/?term=5740 "CYP8, CYP8A1, PGIS, PTGI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017340 57410 SCYL1 http://www.ncbi.nlm.nih.gov/gene/?term=57410 "GKLP, HT019, NKTL, NTKL, P105, SCAR21, TAPK, TEIF, TRAP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017341 57410 SCYL1 http://www.ncbi.nlm.nih.gov/gene/?term=57410 "GKLP, HT019, NKTL, NTKL, P105, SCAR21, TAPK, TEIF, TRAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017342 57412 AS3MT http://www.ncbi.nlm.nih.gov/gene/?term=57412 CYT19 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017343 57412 AS3MT http://www.ncbi.nlm.nih.gov/gene/?term=57412 CYT19 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017344 57414 RHBDD2 http://www.ncbi.nlm.nih.gov/gene/?term=57414 "NPD007, RHBDL7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017345 57418 WDR18 http://www.ncbi.nlm.nih.gov/gene/?term=57418 "Ipi3, R32184_1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017346 57429 Sult5a1 http://www.ncbi.nlm.nih.gov/gene/?term=57429 "Sult-x1, Sultx1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017347 57431 Dnajc4 http://www.ncbi.nlm.nih.gov/gene/?term=57431 "2010301J22Rik, Hspf2, Mcg18 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017348 57436 Gabarapl1 http://www.ncbi.nlm.nih.gov/gene/?term=57436 "3110025G09Rik, 9130422N19Rik, AI196471, Apg8l, Atg8l, GECI, MNCb-0091 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017349 57438 March7 http://www.ncbi.nlm.nih.gov/gene/?term=57438 "Axo, Axot, Gtrgeo17 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017350 57439 Tmem183a http://www.ncbi.nlm.nih.gov/gene/?term=57439 "1300007B12Rik, 1700020N19Rik, Tmem183 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017351 5743 PTGS2 http://www.ncbi.nlm.nih.gov/gene/?term=5743 "COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 " mRNA Homo sapiens 26000482 Ribosome HeLa cell qRT-PCR "Knockdown of Reg1 resulted in a large increase in IL6 and PTGS2 mRNA expression in the polysome fractions (fractions 7-12) compared with control cells, whereas the mRNA in non-polysome fractions (fractions 3-6) were comparable (Figure 3 H). " RLID00017352 57440 Ehd3 http://www.ncbi.nlm.nih.gov/gene/?term=57440 Ehd2 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017353 57441 Gmnn http://www.ncbi.nlm.nih.gov/gene/?term=57441 "AW546347, Gem " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017354 574437 Xlr3b http://www.ncbi.nlm.nih.gov/gene/?term=574437 "EG574437, Xlr3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017355 57443 Fbxo3 http://www.ncbi.nlm.nih.gov/gene/?term=57443 "1200002G09Rik, 1700026K02Rik, AI046358, Fba " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017356 57446 NDRG3 http://www.ncbi.nlm.nih.gov/gene/?term=57446 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017357 57446 NDRG3 http://www.ncbi.nlm.nih.gov/gene/?term=57446 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017358 57446 NDRG3 http://www.ncbi.nlm.nih.gov/gene/?term=57446 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017359 57448 BIRC6 http://www.ncbi.nlm.nih.gov/gene/?term=57448 "APOLLON, BRUCE " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017360 57449 PLEKHG5 http://www.ncbi.nlm.nih.gov/gene/?term=57449 "CMTRIC, DSMA4, GEF720, Syx, Tech " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017361 5744 PTHLH http://www.ncbi.nlm.nih.gov/gene/?term=5744 "BDE2, HHM, PLP, PTHR, PTHRP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017362 57456 KIAA1143 http://www.ncbi.nlm.nih.gov/gene/?term=57456 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017363 57456 KIAA1143 http://www.ncbi.nlm.nih.gov/gene/?term=57456 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017364 57460 PPM1H http://www.ncbi.nlm.nih.gov/gene/?term=57460 "ARHCL1, NERPP-2C, URCC2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017365 57460 PPM1H http://www.ncbi.nlm.nih.gov/gene/?term=57460 "ARHCL1, NERPP-2C, URCC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017366 57462 KIAA1161 http://www.ncbi.nlm.nih.gov/gene/?term=57462 NET37 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017367 57462 KIAA1161 http://www.ncbi.nlm.nih.gov/gene/?term=57462 NET37 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017368 57462 KIAA1161 http://www.ncbi.nlm.nih.gov/gene/?term=57462 NET37 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017369 57464 STRIP2 http://www.ncbi.nlm.nih.gov/gene/?term=57464 "FAM40B, FAR11B " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017370 57464 STRIP2 http://www.ncbi.nlm.nih.gov/gene/?term=57464 "FAM40B, FAR11B " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017371 57464 STRIP2 http://www.ncbi.nlm.nih.gov/gene/?term=57464 "FAM40B, FAR11B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017372 57465 TBC1D24 http://www.ncbi.nlm.nih.gov/gene/?term=57465 "DFNA65, DFNB86, DOORS, EIEE16, FIME, TLDC6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017373 57470 LRRC47 http://www.ncbi.nlm.nih.gov/gene/?term=57470 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017374 57470 LRRC47 http://www.ncbi.nlm.nih.gov/gene/?term=57470 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017375 57470 LRRC47 http://www.ncbi.nlm.nih.gov/gene/?term=57470 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017376 57474 ZNF490 http://www.ncbi.nlm.nih.gov/gene/?term=57474 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017377 57474 ZNF490 http://www.ncbi.nlm.nih.gov/gene/?term=57474 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017378 57475 PLEKHH1 http://www.ncbi.nlm.nih.gov/gene/?term=57475 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017379 57476 GRAMD1B http://www.ncbi.nlm.nih.gov/gene/?term=57476 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017380 57478 USP31 http://www.ncbi.nlm.nih.gov/gene/?term=57478 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017381 57478 USP31 http://www.ncbi.nlm.nih.gov/gene/?term=57478 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017382 57478 USP31 http://www.ncbi.nlm.nih.gov/gene/?term=57478 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017383 57479 PRR12 http://www.ncbi.nlm.nih.gov/gene/?term=57479 KIAA1205 mRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00017384 5747 PTK2 http://www.ncbi.nlm.nih.gov/gene/?term=5747 "FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017385 5747 PTK2 http://www.ncbi.nlm.nih.gov/gene/?term=5747 "FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017386 57481 KIAA1210 http://www.ncbi.nlm.nih.gov/gene/?term=57481 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017387 57481 KIAA1210 http://www.ncbi.nlm.nih.gov/gene/?term=57481 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017388 57486 NLN http://www.ncbi.nlm.nih.gov/gene/?term=57486 "AGTBP, EP24.16, MEP, MOP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017389 57486 NLN http://www.ncbi.nlm.nih.gov/gene/?term=57486 "AGTBP, EP24.16, MEP, MOP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017390 57486 NLN http://www.ncbi.nlm.nih.gov/gene/?term=57486 "AGTBP, EP24.16, MEP, MOP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017391 57488 ESYT2 http://www.ncbi.nlm.nih.gov/gene/?term=57488 "CHR2SYT, E-Syt2, FAM62B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017392 57488 ESYT2 http://www.ncbi.nlm.nih.gov/gene/?term=57488 "CHR2SYT, E-Syt2, FAM62B " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017393 57492 ARID1B http://www.ncbi.nlm.nih.gov/gene/?term=57492 "6A3-5, BAF250B, BRIGHT, DAN15, ELD/OSA1, MRD12, OSA2, P250R " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017394 57493 HEG1 http://www.ncbi.nlm.nih.gov/gene/?term=57493 "HEG, MST112, MSTP112 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017395 57496 MKL2 http://www.ncbi.nlm.nih.gov/gene/?term=57496 "MRTF-B, MRTFB, NPD001 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017396 57496 MKL2 http://www.ncbi.nlm.nih.gov/gene/?term=57496 "MRTF-B, MRTFB, NPD001 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017397 57498 KIDINS220 http://www.ncbi.nlm.nih.gov/gene/?term=57498 ARMS mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017398 57498 KIDINS220 http://www.ncbi.nlm.nih.gov/gene/?term=57498 ARMS mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017399 57502 NLGN4X http://www.ncbi.nlm.nih.gov/gene/?term=57502 "ASPGX2, AUTSX2, HLNX, HNL4X, NLGN4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017400 57504 MTA3 http://www.ncbi.nlm.nih.gov/gene/?term=57504 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017401 57505 AARS2 http://www.ncbi.nlm.nih.gov/gene/?term=57505 "AARSL, COXPD8, LKENP, MT-ALARS, MTALARS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017402 57506 MAVS http://www.ncbi.nlm.nih.gov/gene/?term=57506 "CARDIF, IPS-1, IPS1, VISA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017403 57506 MAVS http://www.ncbi.nlm.nih.gov/gene/?term=57506 "CARDIF, IPS-1, IPS1, VISA " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017404 57507 ZNF608 http://www.ncbi.nlm.nih.gov/gene/?term=57507 NY-REN-36 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017405 57507 ZNF608 http://www.ncbi.nlm.nih.gov/gene/?term=57507 NY-REN-36 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017406 57508 INTS2 http://www.ncbi.nlm.nih.gov/gene/?term=57508 "INT2, KIAA1287 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017407 57508 INTS2 http://www.ncbi.nlm.nih.gov/gene/?term=57508 "INT2, KIAA1287 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017408 57508 INTS2 http://www.ncbi.nlm.nih.gov/gene/?term=57508 "INT2, KIAA1287 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017409 57509 MTUS1 http://www.ncbi.nlm.nih.gov/gene/?term=57509 "ATBP, ATIP, ICIS, MP44, MTSG1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017410 57510 XPO5 http://www.ncbi.nlm.nih.gov/gene/?term=57510 exp5 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017411 57510 XPO5 http://www.ncbi.nlm.nih.gov/gene/?term=57510 exp5 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017412 57510 XPO5 http://www.ncbi.nlm.nih.gov/gene/?term=57510 exp5 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017413 57512 GPR158 http://www.ncbi.nlm.nih.gov/gene/?term=57512 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017414 57513 CASKIN2 http://www.ncbi.nlm.nih.gov/gene/?term=57513 ANKS5B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017415 57515 SERINC1 http://www.ncbi.nlm.nih.gov/gene/?term=57515 "TDE1L, TDE2, TMS-2, TMS2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017416 57515 SERINC1 http://www.ncbi.nlm.nih.gov/gene/?term=57515 "TDE1L, TDE2, TMS-2, TMS2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017417 57515 SERINC1 http://www.ncbi.nlm.nih.gov/gene/?term=57515 "TDE1L, TDE2, TMS-2, TMS2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017418 57519 STARD9 http://www.ncbi.nlm.nih.gov/gene/?term=57519 KIF16A mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017419 57521 RPTOR http://www.ncbi.nlm.nih.gov/gene/?term=57521 "KOG1, Mip1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017420 57521 RPTOR http://www.ncbi.nlm.nih.gov/gene/?term=57521 "KOG1, Mip1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017421 57523 NYNRIN http://www.ncbi.nlm.nih.gov/gene/?term=57523 "CGIN1, KIAA1305 " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00017422 57523 NYNRIN http://www.ncbi.nlm.nih.gov/gene/?term=57523 "CGIN1, KIAA1305 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017423 57531 HACE1 http://www.ncbi.nlm.nih.gov/gene/?term=57531 SPPRS mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017424 57531 HACE1 http://www.ncbi.nlm.nih.gov/gene/?term=57531 SPPRS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017425 57532 NUFIP2 http://www.ncbi.nlm.nih.gov/gene/?term=57532 "182-FIP, 82-FIP, FIP-82, PIG1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017426 57532 NUFIP2 http://www.ncbi.nlm.nih.gov/gene/?term=57532 "182-FIP, 82-FIP, FIP-82, PIG1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017427 57532 NUFIP2 http://www.ncbi.nlm.nih.gov/gene/?term=57532 "182-FIP, 82-FIP, FIP-82, PIG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017428 57533 TBC1D14 http://www.ncbi.nlm.nih.gov/gene/?term=57533 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017429 57534 MIB1 http://www.ncbi.nlm.nih.gov/gene/?term=57534 "DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017430 57534 MIB1 http://www.ncbi.nlm.nih.gov/gene/?term=57534 "DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017431 57534 MIB1 http://www.ncbi.nlm.nih.gov/gene/?term=57534 "DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017432 5753 PTK6 http://www.ncbi.nlm.nih.gov/gene/?term=5753 BRK mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017433 57542 KLHL42 http://www.ncbi.nlm.nih.gov/gene/?term=57542 "Ctb9, KLHDC5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017434 57542 KLHL42 http://www.ncbi.nlm.nih.gov/gene/?term=57542 "Ctb9, KLHDC5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017435 57544 TXNDC16 http://www.ncbi.nlm.nih.gov/gene/?term=57544 "ERp90, KIAA1344 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017436 57545 CC2D2A http://www.ncbi.nlm.nih.gov/gene/?term=57545 "JBTS9, MKS6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017437 57545 CC2D2A http://www.ncbi.nlm.nih.gov/gene/?term=57545 "JBTS9, MKS6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017438 57545 CC2D2A http://www.ncbi.nlm.nih.gov/gene/?term=57545 "JBTS9, MKS6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017439 5754 PTK7 http://www.ncbi.nlm.nih.gov/gene/?term=5754 "CCK-4, CCK4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017440 57551 TAOK1 http://www.ncbi.nlm.nih.gov/gene/?term=57551 "KFC-B, MAP3K16, MARKK, PSK-2, PSK2, TAO1, hKFC-B, hTAOK1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017441 57551 TAOK1 http://www.ncbi.nlm.nih.gov/gene/?term=57551 "KFC-B, MAP3K16, MARKK, PSK-2, PSK2, TAO1, hKFC-B, hTAOK1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017442 57552 NCEH1 http://www.ncbi.nlm.nih.gov/gene/?term=57552 "AADACL1, NCEH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017443 57553 MICAL3 http://www.ncbi.nlm.nih.gov/gene/?term=57553 MICAL-3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017444 57556 SEMA6A http://www.ncbi.nlm.nih.gov/gene/?term=57556 "HT018, SEMA1, SEMAQ, VIA, SEMA6A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017445 57556 SEMA6A http://www.ncbi.nlm.nih.gov/gene/?term=57556 "HT018, SEMA, SEMA6A1, SEMAQ, VIA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017446 57560 IFT80 http://www.ncbi.nlm.nih.gov/gene/?term=57560 "ATD2, SRTD2, WDR56 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017447 57560 IFT80 http://www.ncbi.nlm.nih.gov/gene/?term=57560 "ATD2, SRTD2, WDR56 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017448 57561 ARRDC3 http://www.ncbi.nlm.nih.gov/gene/?term=57561 TLIMP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017449 57561 ARRDC3 http://www.ncbi.nlm.nih.gov/gene/?term=57561 TLIMP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017450 57563 KLHL8 http://www.ncbi.nlm.nih.gov/gene/?term=57563 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017451 57563 KLHL8 http://www.ncbi.nlm.nih.gov/gene/?term=57563 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017452 57568 SIPA1L2 http://www.ncbi.nlm.nih.gov/gene/?term=57568 SPAL2 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017453 5756 TWF1 http://www.ncbi.nlm.nih.gov/gene/?term=5756 "A6, PTK9 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017454 57572 DOCK6 http://www.ncbi.nlm.nih.gov/gene/?term=57572 "AOS2, ZIR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017455 57579 FAM135A http://www.ncbi.nlm.nih.gov/gene/?term=57579 KIAA1411 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017456 5757 PTMA http://www.ncbi.nlm.nih.gov/gene/?term=5757 TMSA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017457 57580 PREX1 http://www.ncbi.nlm.nih.gov/gene/?term=57580 P-REX1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017458 57583 TMEM181 http://www.ncbi.nlm.nih.gov/gene/?term=57583 "GPR178, KIAA1423 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017459 57584 ARHGAP21 http://www.ncbi.nlm.nih.gov/gene/?term=57584 ARHGAP10 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017460 57584 ARHGAP21 http://www.ncbi.nlm.nih.gov/gene/?term=57584 ARHGAP10 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017461 57586 SYT13 http://www.ncbi.nlm.nih.gov/gene/?term=57586 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017462 57586 SYT13 http://www.ncbi.nlm.nih.gov/gene/?term=57586 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017463 57587 CFAP97 http://www.ncbi.nlm.nih.gov/gene/?term=57587 "KIAA1430, hmw " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017464 57589 RIC1 http://www.ncbi.nlm.nih.gov/gene/?term=57589 "CIP150, KIAA1432, bA207C16.1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017465 57590 WDFY1 http://www.ncbi.nlm.nih.gov/gene/?term=57590 "FENS-1, WDF1, ZFYVE17 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017466 57590 WDFY1 http://www.ncbi.nlm.nih.gov/gene/?term=57590 "FENS-1, WDF1, ZFYVE17 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017467 57591 MKL1 http://www.ncbi.nlm.nih.gov/gene/?term=57591 "BSAC, MAL, MRTF-A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017468 57594 HOMEZ http://www.ncbi.nlm.nih.gov/gene/?term=57594 KIAA1443 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017469 57594 HOMEZ http://www.ncbi.nlm.nih.gov/gene/?term=57594 KIAA1443 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017470 57599 WDR48 http://www.ncbi.nlm.nih.gov/gene/?term=57599 "P80, SPG60, UAF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017471 57599 WDR48 http://www.ncbi.nlm.nih.gov/gene/?term=57599 "P80, SPG60, UAF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017472 575 ADGRB1 http://www.ncbi.nlm.nih.gov/gene/?term=575 "BAI1, GDAIF " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017473 57600 FNIP2 http://www.ncbi.nlm.nih.gov/gene/?term=57600 "FNIPL, MAPO1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017474 57600 FNIP2 http://www.ncbi.nlm.nih.gov/gene/?term=57600 "FNIPL, MAPO1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017475 57604 KIAA1456 http://www.ncbi.nlm.nih.gov/gene/?term=57604 "C8orf79, TRM9L " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017476 57604 KIAA1456 http://www.ncbi.nlm.nih.gov/gene/?term=57604 "C8orf79, TRM9L " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017477 57606 SLAIN2 http://www.ncbi.nlm.nih.gov/gene/?term=57606 KIAA1458 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017478 57609 DIP2B http://www.ncbi.nlm.nih.gov/gene/?term=57609 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017479 57610 RANBP10 http://www.ncbi.nlm.nih.gov/gene/?term=57610 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017480 57610 RANBP10 http://www.ncbi.nlm.nih.gov/gene/?term=57610 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017481 57611 ISLR2 http://www.ncbi.nlm.nih.gov/gene/?term=57611 LINX mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017482 57611 ISLR2 http://www.ncbi.nlm.nih.gov/gene/?term=57611 LINX mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017483 57613 FAM234B http://www.ncbi.nlm.nih.gov/gene/?term=57613 KIAA1467 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017484 57613 FAM234B http://www.ncbi.nlm.nih.gov/gene/?term=57613 KIAA1467 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017485 57614 KIAA1468 http://www.ncbi.nlm.nih.gov/gene/?term=57614 "HsT3308, HsT885 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017486 57619 SHROOM3 http://www.ncbi.nlm.nih.gov/gene/?term=57619 "APXL3, MSTP013, SHRM, ShrmL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017487 57620 STIM2 http://www.ncbi.nlm.nih.gov/gene/?term=57620 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017488 57620 STIM2 http://www.ncbi.nlm.nih.gov/gene/?term=57620 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017489 57621 ZBTB2 http://www.ncbi.nlm.nih.gov/gene/?term=57621 ZNF437 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017490 57622 LRFN1 http://www.ncbi.nlm.nih.gov/gene/?term=57622 SALM2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017491 57626 KLHL1 http://www.ncbi.nlm.nih.gov/gene/?term=57626 MRP2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017492 57626 KLHL1 http://www.ncbi.nlm.nih.gov/gene/?term=57626 MRP2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017493 57628 DPP10 http://www.ncbi.nlm.nih.gov/gene/?term=57628 "DPL2, DPPY, DPRP-3, DPRP3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017494 57630 SH3RF1 http://www.ncbi.nlm.nih.gov/gene/?term=57630 "POSH, RNF142, SH3MD2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017495 57633 LRRN1 http://www.ncbi.nlm.nih.gov/gene/?term=57633 "FIGLER3, NLRR-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017496 57634 EP400 http://www.ncbi.nlm.nih.gov/gene/?term=57634 "CAGH32, P400, TNRC12 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017497 5763 PTMS http://www.ncbi.nlm.nih.gov/gene/?term=5763 ParaT mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017498 5763 PTMS http://www.ncbi.nlm.nih.gov/gene/?term=5763 ParaT mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017499 57648 KIAA1522 http://www.ncbi.nlm.nih.gov/gene/?term=57648 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017500 57648 KIAA1522 http://www.ncbi.nlm.nih.gov/gene/?term=57648 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017501 57649 PHF12 http://www.ncbi.nlm.nih.gov/gene/?term=57649 PF1 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017502 5764 PTN http://www.ncbi.nlm.nih.gov/gene/?term=5764 "HARP, HB-GAM, HBBM, HBGF-8, HBGF8, HBNF, HBNF-1, NEGF1, OSF-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017503 5764 PTN http://www.ncbi.nlm.nih.gov/gene/?term=5764 "HARP, HBGF8, HBNF, NEGF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017504 57650 KIAA1524 http://www.ncbi.nlm.nih.gov/gene/?term=57650 "CIP2A, p90 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017505 57654 UVSSA http://www.ncbi.nlm.nih.gov/gene/?term=57654 "KIAA1530, UVSS3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017506 57654 UVSSA http://www.ncbi.nlm.nih.gov/gene/?term=57654 "KIAA1530, UVSS3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017507 57655 GRAMD1A http://www.ncbi.nlm.nih.gov/gene/?term=57655 KIAA1533 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017508 57659 ZBTB4 http://www.ncbi.nlm.nih.gov/gene/?term=57659 "KAISO-L1, ZNF903 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017509 57661 PHRF1 http://www.ncbi.nlm.nih.gov/gene/?term=57661 "PPP1R125, RNF221 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017510 57661 PHRF1 http://www.ncbi.nlm.nih.gov/gene/?term=57661 "PPP1R125, RNF221 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017511 57665 RDH14 http://www.ncbi.nlm.nih.gov/gene/?term=57665 "PAN2, SDR7C4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017512 57669 EPB41L5 http://www.ncbi.nlm.nih.gov/gene/?term=57669 "BE37, YMO1, YRT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017513 57669 EPB41L5 http://www.ncbi.nlm.nih.gov/gene/?term=57669 "BE37, YMO1, YRT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017514 57669 EPB41L5 http://www.ncbi.nlm.nih.gov/gene/?term=57669 "BE37, YMO1, YRT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017515 57673 BEND3 http://www.ncbi.nlm.nih.gov/gene/?term=57673 KIAA1553 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017516 57674 RNF213 http://www.ncbi.nlm.nih.gov/gene/?term=57674 "ALO17, C17orf27, KIAA1618, MYMY2, MYSTR, NET57 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017517 57674 RNF213 http://www.ncbi.nlm.nih.gov/gene/?term=57674 "ALO17, C17orf27, KIAA1618, MYMY2, MYSTR, NET57 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017518 57677 ZFP14 http://www.ncbi.nlm.nih.gov/gene/?term=57677 ZNF531 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017519 57677 ZFP14 http://www.ncbi.nlm.nih.gov/gene/?term=57677 ZNF531 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017520 57678 GPAM http://www.ncbi.nlm.nih.gov/gene/?term=57678 "GPAT, GPAT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017521 57679 ALS2 http://www.ncbi.nlm.nih.gov/gene/?term=57679 "ALS2CR6, ALSJ, IAHSP, PLSJ " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017522 57680 CHD8 http://www.ncbi.nlm.nih.gov/gene/?term=57680 "AUTS18, HELSNF1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017523 57680 CHD8 http://www.ncbi.nlm.nih.gov/gene/?term=57680 "AUTS18, HELSNF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017524 57683 ZDBF2 http://www.ncbi.nlm.nih.gov/gene/?term=57683 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017525 57683 ZDBF2 http://www.ncbi.nlm.nih.gov/gene/?term=57683 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017526 57687 VAT1L http://www.ncbi.nlm.nih.gov/gene/?term=57687 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017527 5768 QSOX1 http://www.ncbi.nlm.nih.gov/gene/?term=5768 "Q6, QSCN6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017528 5768 QSOX1 http://www.ncbi.nlm.nih.gov/gene/?term=5768 "Q6, QSCN6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017529 57695 USP37 http://www.ncbi.nlm.nih.gov/gene/?term=57695 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017530 57696 DDX55 http://www.ncbi.nlm.nih.gov/gene/?term=57696 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017531 57696 DDX55 http://www.ncbi.nlm.nih.gov/gene/?term=57696 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017532 57698 SHTN1 http://www.ncbi.nlm.nih.gov/gene/?term=57698 KIAA1598 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017533 57704 GBA2 http://www.ncbi.nlm.nih.gov/gene/?term=57704 "AD035, NLGase, SPG46 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017534 57707 TLDC1 http://www.ncbi.nlm.nih.gov/gene/?term=57707 KIAA1609 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017535 57708 MIER1 http://www.ncbi.nlm.nih.gov/gene/?term=57708 "ER1, MI-ER1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017536 57708 MIER1 http://www.ncbi.nlm.nih.gov/gene/?term=57708 "ER1, MI-ER1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017537 57709 SLC7A14 http://www.ncbi.nlm.nih.gov/gene/?term=57709 PPP1R142 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017538 57709 SLC7A14 http://www.ncbi.nlm.nih.gov/gene/?term=57709 PPP1R142 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017539 5770 PTPN1 http://www.ncbi.nlm.nih.gov/gene/?term=5770 PTP1B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017540 5770 PTPN1 http://www.ncbi.nlm.nih.gov/gene/?term=5770 PTP1B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017541 57711 ZNF529 http://www.ncbi.nlm.nih.gov/gene/?term=57711 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017542 57711 ZNF529 http://www.ncbi.nlm.nih.gov/gene/?term=57711 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017543 57713 SFMBT2 http://www.ncbi.nlm.nih.gov/gene/?term=57713 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017544 57717 PCDHB16 http://www.ncbi.nlm.nih.gov/gene/?term=57717 "ME1, PCDH-BETA16, PCDH3X, PCDHB8a " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017545 57717 PCDHB16 http://www.ncbi.nlm.nih.gov/gene/?term=57717 "ME1, PCDH-BETA16, PCDH3X, PCDHB8a " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017546 5771 PTPN2 http://www.ncbi.nlm.nih.gov/gene/?term=5771 "PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017547 57720 GPR107 http://www.ncbi.nlm.nih.gov/gene/?term=57720 "GCDRP, LUSTR1, bA138E2.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017548 57720 GPR107 http://www.ncbi.nlm.nih.gov/gene/?term=57720 "GCDRP, LUSTR1, bA138E2.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017549 57722 IGDCC4 http://www.ncbi.nlm.nih.gov/gene/?term=57722 "DDM36, NOPE " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017550 57722 IGDCC4 http://www.ncbi.nlm.nih.gov/gene/?term=57722 "DDM36, NOPE " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017551 57722 IGDCC4 http://www.ncbi.nlm.nih.gov/gene/?term=57722 "DDM36, NOPE " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017552 57724 EPG5 http://www.ncbi.nlm.nih.gov/gene/?term=57724 "HEEW1, KIAA1632, VICIS " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017553 57728 WDR19 http://www.ncbi.nlm.nih.gov/gene/?term=57728 "ATD5, CED4, DYF-2, IFT144, NPHP13, ORF26, Oseg6, PWDMP, SRTD5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017554 57743 Sec61a2 http://www.ncbi.nlm.nih.gov/gene/?term=57743 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017555 57746 Piwil2 http://www.ncbi.nlm.nih.gov/gene/?term=57746 "Piwil1l, mili " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017556 57748 Jmy http://www.ncbi.nlm.nih.gov/gene/?term=57748 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017557 57750 Wdr12 http://www.ncbi.nlm.nih.gov/gene/?term=57750 "4933402C23Rik, Ytm1, Ytm1p " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017558 57753 Noc3l http://www.ncbi.nlm.nih.gov/gene/?term=57753 "AF233884, Fad24 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017559 57758 SCUBE2 http://www.ncbi.nlm.nih.gov/gene/?term=57758 "CEGB1, CEGF1, CEGP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017560 57761 TRIB3 http://www.ncbi.nlm.nih.gov/gene/?term=57761 "C20orf97, NIPK, SINK, SKIP3, TRB3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017561 57763 ANKRA2 http://www.ncbi.nlm.nih.gov/gene/?term=57763 ANKRA mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017562 57763 ANKRA2 http://www.ncbi.nlm.nih.gov/gene/?term=57763 ANKRA mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017563 57776 Ttyh1 http://www.ncbi.nlm.nih.gov/gene/?term=57776 "4930459B04Rik, 6330408P11Rik, TTY1, mTTY1, tty " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017564 57782 Rbak http://www.ncbi.nlm.nih.gov/gene/?term=57782 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017565 57783 Tnip1 http://www.ncbi.nlm.nih.gov/gene/?term=57783 "ABIN, ABIN-1, ABIN1, AU018810, Naf1, Nef, VAN " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017566 57786 RBAK http://www.ncbi.nlm.nih.gov/gene/?term=57786 ZNF769 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017567 5778 PTPN7 http://www.ncbi.nlm.nih.gov/gene/?term=5778 "BPTP-4, HEPTP, LC-PTP, LPTP, PTPNI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017568 57794 SUGP1 http://www.ncbi.nlm.nih.gov/gene/?term=57794 "F23858, RBP, SF4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017569 57798 GATAD1 http://www.ncbi.nlm.nih.gov/gene/?term=57798 "CMD2B, ODAG, RG083M05.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017570 57799 RAB40C http://www.ncbi.nlm.nih.gov/gene/?term=57799 "RARL, RASL8C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017571 57799 RAB40C http://www.ncbi.nlm.nih.gov/gene/?term=57799 "RARL, RASL8C " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017572 577 ADGRB3 http://www.ncbi.nlm.nih.gov/gene/?term=577 BAI3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017573 57801 HES4 http://www.ncbi.nlm.nih.gov/gene/?term=57801 bHLHb42 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017574 57804 POLD4 http://www.ncbi.nlm.nih.gov/gene/?term=57804 "POLDS, p12 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017575 57805 CCAR2 http://www.ncbi.nlm.nih.gov/gene/?term=57805 "DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017576 57805 CCAR2 http://www.ncbi.nlm.nih.gov/gene/?term=57805 "DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017577 57808 Rpl35a http://www.ncbi.nlm.nih.gov/gene/?term=57808 "2810431L15Rik, Rpl35 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017578 57808 Rpl35a http://www.ncbi.nlm.nih.gov/gene/?term=57808 "2810431L15Rik, Rpl35 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00017579 5780 PTPN9 http://www.ncbi.nlm.nih.gov/gene/?term=5780 "MEG2, PTPMEG2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017580 5780 PTPN9 http://www.ncbi.nlm.nih.gov/gene/?term=5780 "MEG2, PTPMEG2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017581 57815 Spata5 http://www.ncbi.nlm.nih.gov/gene/?term=57815 "2510048F20Rik, C78064, Spaf " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017582 57815 Spata5 http://www.ncbi.nlm.nih.gov/gene/?term=57815 "2510048F20Rik, C78064, Spaf " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017583 57817 HAMP http://www.ncbi.nlm.nih.gov/gene/?term=57817 "HEPC, HFE2B, LEAP1, PLTR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017584 57818 G6PC2 http://www.ncbi.nlm.nih.gov/gene/?term=57818 IGRP mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017585 57818 G6PC2 http://www.ncbi.nlm.nih.gov/gene/?term=57818 IGRP mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017586 57819 LSM2 http://www.ncbi.nlm.nih.gov/gene/?term=57819 "C6orf28, G7B, YBL026W, snRNP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017587 5781 PTPN11 http://www.ncbi.nlm.nih.gov/gene/?term=5781 "BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017588 5781 PTPN11 http://www.ncbi.nlm.nih.gov/gene/?term=5781 "BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017589 5781 PTPN11 http://www.ncbi.nlm.nih.gov/gene/?term=5781 "BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017590 57820 CCNB1IP1 http://www.ncbi.nlm.nih.gov/gene/?term=57820 "C14orf18, HEI10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017591 57820 CCNB1IP1 http://www.ncbi.nlm.nih.gov/gene/?term=57820 "C14orf18, HEI10 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017592 57820 CCNB1IP1 http://www.ncbi.nlm.nih.gov/gene/?term=57820 "C14orf18, HEI10 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017593 57826 RAP2C http://www.ncbi.nlm.nih.gov/gene/?term=57826 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017594 57827 C6orf47 http://www.ncbi.nlm.nih.gov/gene/?term=57827 "D6S53E, G4, NG34 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017595 5782 PTPN12 http://www.ncbi.nlm.nih.gov/gene/?term=5782 "PTP-PEST, PTPG1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017596 5782 PTPN12 http://www.ncbi.nlm.nih.gov/gene/?term=5782 "PTP-PEST, PTPG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017597 57835 SLC4A5 http://www.ncbi.nlm.nih.gov/gene/?term=57835 NBC4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017598 5783 PTPN13 http://www.ncbi.nlm.nih.gov/gene/?term=5783 "FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017599 5783 PTPN13 http://www.ncbi.nlm.nih.gov/gene/?term=5783 "FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017600 57862 ZNF410 http://www.ncbi.nlm.nih.gov/gene/?term=57862 "APA-1, APA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017601 57869 Adck2 http://www.ncbi.nlm.nih.gov/gene/?term=57869 "AA408112, BB006057 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017602 5786 PTPRA http://www.ncbi.nlm.nih.gov/gene/?term=5786 "HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, R-PTP-alpha, RPTPA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017603 57874 Hacd3 http://www.ncbi.nlm.nih.gov/gene/?term=57874 "4930523M17Rik, AW742319, B-ind1, Hcad3, Hspc121, Ptplad1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017604 5787 PTPRB http://www.ncbi.nlm.nih.gov/gene/?term=5787 "HPTP-BETA, HPTPB, PTPB, R-PTP-BETA, VEPTP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017605 5787 PTPRB http://www.ncbi.nlm.nih.gov/gene/?term=5787 "HPTP-BETA, HPTPB, PTPB, R-PTP-BETA, VEPTP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017606 5787 PTPRB http://www.ncbi.nlm.nih.gov/gene/?term=5787 "HPTP-BETA, HPTPB, PTPB, R-PTP-BETA, VEPTP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017607 5788 PTPRC http://www.ncbi.nlm.nih.gov/gene/?term=5788 "B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00017608 5788 PTPRC http://www.ncbi.nlm.nih.gov/gene/?term=5788 "B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017609 5788 PTPRC http://www.ncbi.nlm.nih.gov/gene/5788 "LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00017610 5789 PTPRD http://www.ncbi.nlm.nih.gov/gene/?term=5789 "HPTP, HPTPD, HPTPDELTA, PTPD, RPTPDELTA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017611 578 BAK1 http://www.ncbi.nlm.nih.gov/gene/?term=578 "BAK, BAK-LIKE, BCL2L7, CDN1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017612 578 BAK1 http://www.ncbi.nlm.nih.gov/gene/?term=578 "BAK, BAK-LIKE, BCL2L7, CDN1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017613 57905 Isy1 http://www.ncbi.nlm.nih.gov/gene/?term=57905 "5830446M03Rik, AI181014, AU020769 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017614 57908 Zfp318 http://www.ncbi.nlm.nih.gov/gene/?term=57908 "2610034E08Rik, D530032D06Rik, TZF, Znf318 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017615 57912 Cdc42se1 http://www.ncbi.nlm.nih.gov/gene/?term=57912 "1300002M12Rik, AW558204, Cdcse1, SCIP1, Spec1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017616 5791 PTPRE http://www.ncbi.nlm.nih.gov/gene/?term=5791 "HPTPE, PTPE, R-PTP-EPSILON " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017617 5791 PTPRE http://www.ncbi.nlm.nih.gov/gene/?term=5791 "HPTPE, PTPE, R-PTP-EPSILON " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017618 5792 PTPRF http://www.ncbi.nlm.nih.gov/gene/?term=5792 "BNAH2, LAR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017619 5792 PTPRF http://www.ncbi.nlm.nih.gov/gene/?term=5792 "BNAH2, LAR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017620 5793 PTPRG http://www.ncbi.nlm.nih.gov/gene/?term=5793 "HPTPG, PTPG, R-PTP-GAMMA, RPTPG " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017621 5793 PTPRG http://www.ncbi.nlm.nih.gov/gene/?term=5793 "HPTPG, PTPG, R-PTP-GAMMA, RPTPG " mRNA Homo sapiens 19662205 Dendrite Monocytes Northern blot "We have recently demonstrated that PTPgamma mRNA is expressed in monocytes, tissue-localized myeloid dendritic cells and in both myeloid and plasmacytoid dendritic cells in peripheral blood. " RLID00017622 5793 PTPRG http://www.ncbi.nlm.nih.gov/gene/?term=5793 "HPTPG, PTPG, R-PTP-GAMMA, RPTPG " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017623 5795 PTPRJ http://www.ncbi.nlm.nih.gov/gene/?term=5795 "CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017624 5796 PTPRK http://www.ncbi.nlm.nih.gov/gene/?term=5796 R-PTP-kappa mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017625 5796 PTPRK http://www.ncbi.nlm.nih.gov/gene/?term=5796 R-PTP-kappa mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017626 5798 PTPRN http://www.ncbi.nlm.nih.gov/gene/?term=5798 "IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017627 5799 PTPRN2 http://www.ncbi.nlm.nih.gov/gene/?term=5799 "IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017628 5801 PTPRR http://www.ncbi.nlm.nih.gov/gene/?term=5801 "EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017629 5802754 SPRRNA.31 http://www.ncbi.nlm.nih.gov/gene/?term=5802754 SPRRNA.31 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.31 RLID00017630 5802769 SPRRNA.32 http://www.ncbi.nlm.nih.gov/gene/?term=5802769 SPRRNA.32 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.32 RLID00017631 5802772 SPRRNA.33 http://www.ncbi.nlm.nih.gov/gene/?term=5802772 SPRRNA.33 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.33 RLID00017632 5802814 SPRRNA.41 http://www.ncbi.nlm.nih.gov/gene/?term=5802814 SPRRNA.41 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.41 RLID00017633 5802824 SPRRNA.36 http://www.ncbi.nlm.nih.gov/gene/?term=5802824 SPRRNA.36 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.36 RLID00017634 5802825 snu32 http://www.ncbi.nlm.nih.gov/gene/?term=5802825 SPSNRNA.07 snoRNA Saccharomyces cerevisiae 25361970 Nucleolus - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPSNRNA.07 RLID00017635 5802833 SPRRNA.38 http://www.ncbi.nlm.nih.gov/gene/?term=5802833 SPRRNA.38 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.38 RLID00017636 5802949 snoR54b http://www.ncbi.nlm.nih.gov/gene/?term=5802949 SPSNORNA.14 snoRNA Saccharomyces cerevisiae 25361970 Nucleolus - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPSNORNA.14 RLID00017637 5802 PTPRS http://www.ncbi.nlm.nih.gov/gene/?term=5802 PTPSIGMA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017638 5802 PTPRS http://www.ncbi.nlm.nih.gov/gene/?term=5802 PTPSIGMA mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017639 58039 dazl http://www.ncbi.nlm.nih.gov/gene/?term=58039 mRNA Danio rerio 10330505 Vegetal Embryo In situ hybridization "In ovary, it was localized in the cortex of oocytes. At the onset of embryogenesis, maternal zDazl mRNA was detected at the vegetal pole. It migrated toward blastomeres through cytoplasmic streams as early embryogenesis proceeded. This is the first report showing maternal mRNA localization at the vegetal pole in fish and the existence of mRNA streams in the yolk cytoplasm. " RLID00017640 58039 dazl http://www.ncbi.nlm.nih.gov/gene/?term=58039 mRNA Danio rerio 10781958 Vegetal Oocyte In situ hybridization "Both brul and dazl mRNAs were localized at the vegetal cortex in the stage III-oocyte (Fig. 5C,F). " RLID00017641 58039 dazl http://www.ncbi.nlm.nih.gov/gene/?term=58039 mRNA Danio rerio 17293094 Germ plasm Oocyte In situ hybridization "Here we report that the germ plasm RNAs vasa, nanos1, and dazl co-localize with the mitochondrial cloud (MC) and are transported to the vegetal cortex during early oogenesis. " RLID00017642 58039 dazl http://www.ncbi.nlm.nih.gov/gene/?term=58039 mRNA Danio rerio 17293094 Mitochondrion Oocyte In situ hybridization "Here we report that the germ plasm RNAs vasa, nanos1, and dazl co-localize with the mitochondrial cloud (MC) and are transported to the vegetal cortex during early oogenesis. " RLID00017643 58039 dazl http://www.ncbi.nlm.nih.gov/gene/?term=58039 mRNA Danio rerio 24967891 Vegetal Embryo In situ hybridization "The localization patterns of dazl mRNA, a germ plasm component initially localized to the vegetal pole of the egg ([36,46,47]; Figure 8A), is not affected in these mutants (Figure 8D). " RLID00017644 58039 dazl http://www.ncbi.nlm.nih.gov/gene/?term=58039 mRNA Danio rerio 26528729 Vegetal Embryo Fluorescence in situ hybridization "FIGURE 2. Dual label FISH of pairwise comparisons of wnt8a, grip2a and dazl mRNA localization at the vegetal cortex. (A-C) dazl (green) and wnt8a (red). (D-F) grip2a (green) and dazl (red). (G-I) grip2a (green) and wnt8a (red). In all cases mRNAs localize to discrete units, which do not overlap between different RNAs. Embryos are wild type fixed at 20mpf. Panels are 2-D projections of imaged vegetal cortex samples. Scale bar in (I) represents 5mm for all images. (Color figure available online.) " RLID00017645 5805 PTS http://www.ncbi.nlm.nih.gov/gene/?term=5805 PTPS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017646 5805 PTS http://www.ncbi.nlm.nih.gov/gene/?term=5805 PTPS mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017647 5805 PTS http://www.ncbi.nlm.nih.gov/gene/?term=5805 PTPS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017648 580 BARD1 http://www.ncbi.nlm.nih.gov/gene/?term=580 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017649 580 BARD1 http://www.ncbi.nlm.nih.gov/gene/?term=580 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017650 580 BARD1 http://www.ncbi.nlm.nih.gov/gene/?term=580 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017651 5810 RAD1 http://www.ncbi.nlm.nih.gov/gene/?term=5810 "HRAD1, REC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017652 58137 celf1 http://www.ncbi.nlm.nih.gov/gene/?term=58137 "Bruno-like, brul, cb920, cugbp1 " mRNA Danio rerio 10781958 Vegetal Oocyte In situ hybridization "At the onset of embryogenesis, brulmRNA was localized at the vegetal pole, and it then migrated toward the blastoderm (Fig. 3A±C).Fig. 3. brul mRNA localization during early embryogenesis. (A) Five minutes after fertilization, brulmRNA is localized at the vegetal pole. (B) Thirty minutes after fertilization, the mRNA streams toward the blastodisc of the zygote " RLID00017653 58137 celf1 http://www.ncbi.nlm.nih.gov/gene/?term=58137 "Bruno-like, brul, cb920, cugbp1 " mRNA Danio rerio 10781958 Vegetal Oocyte In situ hybridization "In the same oocyte, brul mRNA was accumulated at the vegetal cortex, although it was also detectable around the germinal vesicle (Fig. 4A). " RLID00017654 5813 PURA http://www.ncbi.nlm.nih.gov/gene/?term=5813 "MRD31, PUR-ALPHA, PUR1LPHA, PURA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017655 5813 PURA http://www.ncbi.nlm.nih.gov/gene/?term=5813 "MRD31, PUR-ALPHA, PUR1, PURALPHA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017656 5814 PURB http://www.ncbi.nlm.nih.gov/gene/?term=5814 PURBETA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017657 5814 PURB http://www.ncbi.nlm.nih.gov/gene/?term=5814 PURBETA mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017658 58155 PTBP2 http://www.ncbi.nlm.nih.gov/gene/?term=58155 "PTBLP, brPTB, nPTB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017659 58158 NEUROD4 http://www.ncbi.nlm.nih.gov/gene/?term=58158 "ATH-3, ATH3, Atoh3, MATH-3, MATH3, bHLHa4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017660 58172 Sertad2 http://www.ncbi.nlm.nih.gov/gene/?term=58172 "AB041541, AU021878, Kiaa0127, MNCb-1504, SEI-2, Sei2, TRIP-Br2, mKIAA0127 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017661 58175 Rgs20 http://www.ncbi.nlm.nih.gov/gene/?term=58175 "2900073E09Rik, Rgsz1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017662 58175 Rgs20 http://www.ncbi.nlm.nih.gov/gene/?term=58175 "2900073E09Rik, Rgsz1 " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00017663 5817 PVR http://www.ncbi.nlm.nih.gov/gene/?term=5817 "CD155, HVED, NECL5, Necl-5, PVS, TAGE4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017664 5817 PVR http://www.ncbi.nlm.nih.gov/gene/?term=5817 "CD155, HVED, NECL5, Necl-5, PVS, TAGE4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017665 58180 Hic2 http://www.ncbi.nlm.nih.gov/gene/?term=58180 "AA409108, HRG22, mKIAA1020 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017666 58186 Rad18 http://www.ncbi.nlm.nih.gov/gene/?term=58186 "2810024C04Riksc, Rad18 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017667 58186 Rad18 http://www.ncbi.nlm.nih.gov/gene/?term=58186 "2810024C04Riksc, Rad18 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017668 5818 NECTIN1 http://www.ncbi.nlm.nih.gov/gene/?term=5818 "CD111, CLPED1, ED4, HIgR, HV1S, HVEC, OFC7, PRR, PRR1, PVRL1, PVRR, PVRR1, SK-12, nectin-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017669 58190 CTDSP1 http://www.ncbi.nlm.nih.gov/gene/?term=58190 "NIF3, NLI-IF, NLIIF, SCP1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017670 58191 CXCL16 http://www.ncbi.nlm.nih.gov/gene/?term=58191 "CXCLG16, SR-PSOX, SRPSOX " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017671 58191 CXCL16 http://www.ncbi.nlm.nih.gov/gene/?term=58191 "CXCLG16, SR-PSOX, SRPSOX " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017672 58191 CXCL16 http://www.ncbi.nlm.nih.gov/gene/?term=58191 "CXCLG16, SR-PSOX, SRPSOX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017673 58193 Extl2 http://www.ncbi.nlm.nih.gov/gene/?term=58193 "3000001D04Rik, AW146439 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017674 58194 Sh3kbp1 http://www.ncbi.nlm.nih.gov/gene/?term=58194 "1200007H22Rik, 1700125L08Rik, 5830464D22Rik, AI447724, IN85, Ruk, Seta " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017675 5819 NECTIN2 http://www.ncbi.nlm.nih.gov/gene/?term=5819 "CD112, HVEB, PRR2, PVRL2, PVRR2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017676 581 BAX http://www.ncbi.nlm.nih.gov/gene/?term=581 BCL2L4 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017677 58202 Nelfb http://www.ncbi.nlm.nih.gov/gene/?term=58202 "A730008L03Rik, AB041607, AI663983, Cobra1, Nelf-b " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017678 5820 PVT1 http://www.ncbi.nlm.nih.gov/gene/?term=5820 "LINC00079, NCRNA00079, onco-lncRNA-100 " lncRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017679 58212 Srrm3 http://www.ncbi.nlm.nih.gov/gene/?term=58212 "2900083I11Rik, AB041661, SRm300-like, Srrm2l " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017680 5822 PWP2 http://www.ncbi.nlm.nih.gov/gene/?term=5822 "EHOC-17H, UTP1, PWP2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017681 5822 PWP2 http://www.ncbi.nlm.nih.gov/gene/?term=5822 "EHOC-17, PWP2H, UTP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017682 58231 Stk4 http://www.ncbi.nlm.nih.gov/gene/?term=58231 "AI447339, AU020804, Kas-2, Mst1, Ysk3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017683 58237 Nkain4 http://www.ncbi.nlm.nih.gov/gene/?term=58237 "AB030182, C030019F02Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017684 58239 Dexi http://www.ncbi.nlm.nih.gov/gene/?term=58239 "1810029J14Rik, AI836170, AW413143, D16Bwg0586e, Myle " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017685 58240 Hs1bp3 http://www.ncbi.nlm.nih.gov/gene/?term=58240 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017686 58243 Nap1l5 http://www.ncbi.nlm.nih.gov/gene/?term=58243 1110020M21Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017687 58245 Gpr180 http://www.ncbi.nlm.nih.gov/gene/?term=58245 "AB041545, E130016I23Rik, Itr " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017688 58249 Fibp http://www.ncbi.nlm.nih.gov/gene/?term=58249 "2010004G08Rik, 2010005N21Rik, 3010027N18Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017689 5824 PEX19 http://www.ncbi.nlm.nih.gov/gene/?term=5824 "D1S2223E, HK33, PBD12A, PMP1, PMPI, PXF, PXMP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017690 58250 Chst11 http://www.ncbi.nlm.nih.gov/gene/?term=58250 "1110020P09Rik, C4ST, C4ST-1, C4ST1, C4s " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017691 5825 ABCD3 http://www.ncbi.nlm.nih.gov/gene/?term=5825 "ABC43, CBAS5, PMP70, PXMP1, ZWS2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017692 5825 ABCD3 http://www.ncbi.nlm.nih.gov/gene/?term=5825 "ABC43, CBAS5, PMP70, PXMP1, ZWS2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017693 5826 ABCD4 http://www.ncbi.nlm.nih.gov/gene/?term=5826 "ABC41, EST352188, MAHCJ, P70R, P79R, PMP69, PXMP1L " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017694 5827 PXMP2 http://www.ncbi.nlm.nih.gov/gene/?term=5827 PMP22 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017695 5827 PXMP2 http://www.ncbi.nlm.nih.gov/gene/?term=5827 PMP22 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017696 5828 PEX2 http://www.ncbi.nlm.nih.gov/gene/?term=5828 "PAF1, PBD5A, PBD5B, PMP3, PMP35, PXMP3, RNF72, ZWS3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017697 5828 PEX2 http://www.ncbi.nlm.nih.gov/gene/?term=5828 "PAF1, PBD5A, PBD5B, PMP3, PMP35, PXMP3, RNF72, ZWS3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017698 5828 PEX2 http://www.ncbi.nlm.nih.gov/gene/?term=5828 "PAF1, PBD5A, PBD5B, PMP3, PMP35, PXMP3, RNF72, ZWS3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017699 5828 PEX2 http://www.ncbi.nlm.nih.gov/gene/?term=5828 "PAF1, PBD5A, PBD5B, PMP3, PMP35, PXMP3, RNF72, ZWS3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017700 5829 PXN http://www.ncbi.nlm.nih.gov/gene/?term=5829 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017701 5830 PEX5 http://www.ncbi.nlm.nih.gov/gene/?term=5830 "PBD2A, PBD2B, PTS1-BP, PTS1R, PXR1, RCDP5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017702 5831 PYCR1 http://www.ncbi.nlm.nih.gov/gene/?term=5831 "ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017703 5832 ALDH18A1 http://www.ncbi.nlm.nih.gov/gene/?term=5832 "ADCL3, ARCL3A, GSAS, P5CS, PYCS, SPG9A, SPG9B " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017704 5832 ALDH18A1 http://www.ncbi.nlm.nih.gov/gene/?term=5832 "ADCL3, ARCL3A, GSAS, P5CS, PYCS, SPG9A, SPG9B " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017705 5833 PCYT2 http://www.ncbi.nlm.nih.gov/gene/?term=5833 ET mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017706 5833 PCYT2 http://www.ncbi.nlm.nih.gov/gene/?term=5833 ET mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017707 5834 PYGB http://www.ncbi.nlm.nih.gov/gene/?term=5834 GPBB mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017708 5834 PYGB http://www.ncbi.nlm.nih.gov/gene/?term=5834 GPBB mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017709 5834 PYGB http://www.ncbi.nlm.nih.gov/gene/?term=5834 GPBB mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017710 5836 PYGL http://www.ncbi.nlm.nih.gov/gene/?term=5836 GSD6 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017711 5836 PYGL http://www.ncbi.nlm.nih.gov/gene/?term=5836 GSD6 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017712 5837 PYGM http://www.ncbi.nlm.nih.gov/gene/?term=5837 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017713 583 BBS2 http://www.ncbi.nlm.nih.gov/gene/?term=583 "BBS, RP74 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017714 583 BBS2 http://www.ncbi.nlm.nih.gov/gene/?term=583 "BBS, RP74 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017715 583 BBS2 http://www.ncbi.nlm.nih.gov/gene/?term=583 "BBS, RP74 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017716 58475 MS4A7 http://www.ncbi.nlm.nih.gov/gene/?term=58475 "4SPAN2, CD20L4, CFFM4, MS4A8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017717 58477 SRPRB http://www.ncbi.nlm.nih.gov/gene/?term=58477 APMCF1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017718 58477 SRPRB http://www.ncbi.nlm.nih.gov/gene/?term=58477 APMCF1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017719 58477 SRPRB http://www.ncbi.nlm.nih.gov/gene/?term=58477 APMCF1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017720 58478 ENOPH1 http://www.ncbi.nlm.nih.gov/gene/?term=58478 "E1, MASA, MST145, mtnC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017721 58478 ENOPH1 http://www.ncbi.nlm.nih.gov/gene/?term=58478 "E1, MASA, MST145, mtnC " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017722 58478 ENOPH1 http://www.ncbi.nlm.nih.gov/gene/?term=58478 "E1, MASA, MST145, mtnC " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017723 58478 ENOPH1 http://www.ncbi.nlm.nih.gov/gene/?term=58478 "E1, MASA, MST145, mtnC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017724 58480 RHOU http://www.ncbi.nlm.nih.gov/gene/?term=58480 "ARHU, CDC42L1, G28K, WRCH1, hG28K " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017725 58485 TRAPPC1 http://www.ncbi.nlm.nih.gov/gene/?term=58485 "BET5, MUM2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017726 58485 TRAPPC1 http://www.ncbi.nlm.nih.gov/gene/?term=58485 "BET5, MUM2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017727 58486 ZBED5 http://www.ncbi.nlm.nih.gov/gene/?term=58486 Buster1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017728 58486 ZBED5 http://www.ncbi.nlm.nih.gov/gene/?term=58486 Buster1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017729 58487 CREBZF http://www.ncbi.nlm.nih.gov/gene/?term=58487 "SMILE, ZF " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017730 58487 CREBZF http://www.ncbi.nlm.nih.gov/gene/?term=58487 "SMILE, ZF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017731 58488 PCTP http://www.ncbi.nlm.nih.gov/gene/?term=58488 "PC-TP, STARD2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017732 58488 PCTP http://www.ncbi.nlm.nih.gov/gene/?term=58488 "PC-TP, STARD2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017733 58488 PCTP http://www.ncbi.nlm.nih.gov/gene/?term=58488 "PC-TP, STARD2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017734 58490 RPRD1B http://www.ncbi.nlm.nih.gov/gene/?term=58490 "C20orf77, CREPT, NET60, dJ1057B20.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017735 58490 RPRD1B http://www.ncbi.nlm.nih.gov/gene/?term=58490 "C20orf77, CREPT, NET60, dJ1057B20.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017736 58493 INIP http://www.ncbi.nlm.nih.gov/gene/?term=58493 "C9orf80, HSPC043, MISE, SOSSC, SSBIP1, hSSBIP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017737 58497 PRUNE http://www.ncbi.nlm.nih.gov/gene/?term=58497 "DRES-17, DRES17, HTCD37 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017738 58497 PRUNE http://www.ncbi.nlm.nih.gov/gene/?term=58497 "DRES-17, DRES17, HTCD37 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017739 58498 MYL7 http://www.ncbi.nlm.nih.gov/gene/?term=58498 "MYL2A, MYLC2A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017740 58500 ZNF250 http://www.ncbi.nlm.nih.gov/gene/?term=58500 "ZFP647, ZNF647 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017741 58500 ZNF250 http://www.ncbi.nlm.nih.gov/gene/?term=58500 "ZFP647, ZNF647 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017742 58505 OSTC http://www.ncbi.nlm.nih.gov/gene/?term=58505 DC2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017743 58506 SCAF1 http://www.ncbi.nlm.nih.gov/gene/?term=58506 SRA1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017744 58508 KMT2C http://www.ncbi.nlm.nih.gov/gene/?term=58508 "HALR, MLL3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017745 58508 KMT2C http://www.ncbi.nlm.nih.gov/gene/?term=58508 "HALR, MLL3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017746 58509 CACTIN http://www.ncbi.nlm.nih.gov/gene/?term=58509 "C19orf29, NY-REN-24, fSAPc " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017747 58509 CACTIN http://www.ncbi.nlm.nih.gov/gene/?term=58509 "C19orf29, NY-REN-24, fSAPc " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017748 58515 SELK http://www.ncbi.nlm.nih.gov/gene/?term=58515 "HSPC030, HSPC297, SelK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017749 58515 SELK http://www.ncbi.nlm.nih.gov/gene/?term=58515 "HSPC030, HSPC297, SelK " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017750 58516 FAM60A http://www.ncbi.nlm.nih.gov/gene/?term=58516 "C12orf14, L4, TERA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017751 58516 FAM60A http://www.ncbi.nlm.nih.gov/gene/?term=58516 "C12orf14, L4, TERA " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017752 58516 FAM60A http://www.ncbi.nlm.nih.gov/gene/?term=58516 "C12orf14, L4, TERA " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017753 58517 RBM25 http://www.ncbi.nlm.nih.gov/gene/?term=58517 "NET52, RED120, RNPC7, S164, Snu71, fSAP94 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017754 58517 RBM25 http://www.ncbi.nlm.nih.gov/gene/?term=58517 "NET52, RED120, RNPC7, S164, Snu71, fSAP94 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017755 58517 RBM25 http://www.ncbi.nlm.nih.gov/gene/?term=58517 "NET52, RED120, RNPC7, S164, Snu71, fSAP94 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017756 58525 WIZ http://www.ncbi.nlm.nih.gov/gene/?term=58525 ZNF803 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017757 58527 ABRACL http://www.ncbi.nlm.nih.gov/gene/?term=58527 "C6orf115, Costars, HSPC280, PRO2013 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017758 58533 SNX6 http://www.ncbi.nlm.nih.gov/gene/?term=58533 "MSTP010, TFAF2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017759 58533 SNX6 http://www.ncbi.nlm.nih.gov/gene/?term=58533 "MSTP010, TFAF2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017760 58533 SNX6 http://www.ncbi.nlm.nih.gov/gene/?term=58533 "MSTP010, TFAF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017761 5859 QARS http://www.ncbi.nlm.nih.gov/gene/?term=5859 "GLNRS, MSCCA, PRO2195 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017762 5859 QARS http://www.ncbi.nlm.nih.gov/gene/?term=5859 "GLNRS, MSCCA, PRO2195 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017763 5859 QARS http://www.ncbi.nlm.nih.gov/gene/?term=5859 "GLNRS, MSCCA, PRO2195 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017764 585 BBS4 http://www.ncbi.nlm.nih.gov/gene/?term=585 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017765 585 BBS4 http://www.ncbi.nlm.nih.gov/gene/?term=585 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017766 5860 QDPR http://www.ncbi.nlm.nih.gov/gene/?term=5860 "DHPR, PKU2, SDR33C1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017767 5860 QDPR http://www.ncbi.nlm.nih.gov/gene/?term=5860 "DHPR, PKU2, SDR33C1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017768 5861 RAB1A http://www.ncbi.nlm.nih.gov/gene/?term=5861 "RAB1, YPT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017769 5861 RAB1A http://www.ncbi.nlm.nih.gov/gene/?term=5861 "RAB1, YPT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017770 5862 RAB2A http://www.ncbi.nlm.nih.gov/gene/?term=5862 "LHX, RAB2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017771 5862 RAB2A http://www.ncbi.nlm.nih.gov/gene/?term=5862 "LHX, RAB2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017772 5863 RGL2 http://www.ncbi.nlm.nih.gov/gene/?term=5863 "HKE1.5, KE1.5, RAB2L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017773 5863 RGL2 http://www.ncbi.nlm.nih.gov/gene/?term=5863 "HKE1.5, KE1.5, RAB2L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017774 5864 RAB3A http://www.ncbi.nlm.nih.gov/gene/?term=5864 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017775 5865 RAB3B http://www.ncbi.nlm.nih.gov/gene/?term=5865 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017776 5865 RAB3B http://www.ncbi.nlm.nih.gov/gene/?term=5865 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017777 5866 RAB3IL1 http://www.ncbi.nlm.nih.gov/gene/?term=5866 GRAB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017778 5867 RAB4A http://www.ncbi.nlm.nih.gov/gene/?term=5867 "HRES-1, HRES-1/RAB4, HRES1, RAB4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017779 5867 RAB4A http://www.ncbi.nlm.nih.gov/gene/?term=5867 "HRES-1, HRES-1/RAB4, HRES1, RAB4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017780 5867 RAB4A http://www.ncbi.nlm.nih.gov/gene/?term=5867 "HRES-1, HRES-1/RAB4, HRES1, RAB4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017781 5868 RAB5A http://www.ncbi.nlm.nih.gov/gene/?term=5868 RAB5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017782 5868 RAB5A http://www.ncbi.nlm.nih.gov/gene/?term=5868 RAB5 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017783 5869 RAB5B http://www.ncbi.nlm.nih.gov/gene/?term=5869 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017784 586 BCAT1 http://www.ncbi.nlm.nih.gov/gene/?term=586 "BCATC, BCT1, ECA39, MECA39, PNAS121, PP18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017785 5870 RAB6A http://www.ncbi.nlm.nih.gov/gene/?term=5870 RAB6 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017786 5870 RAB6A http://www.ncbi.nlm.nih.gov/gene/?term=5870 RAB6 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017787 5871 MAP4K2 http://www.ncbi.nlm.nih.gov/gene/?term=5871 "BL44, GCK, RAB8IP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017788 5873 RAB27A http://www.ncbi.nlm.nih.gov/gene/?term=5873 "GS2, HsT18676, RAB27, RAM " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017789 5873 RAB27A http://www.ncbi.nlm.nih.gov/gene/?term=5873 "GS2, HsT18676, RAB27, RAM " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017790 5873 RAB27A http://www.ncbi.nlm.nih.gov/gene/?term=5873 "GS2, HsT18676, RAB27, RAM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017791 5875 RABGGTA http://www.ncbi.nlm.nih.gov/gene/?term=5875 PTAR3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017792 5876 RABGGTB http://www.ncbi.nlm.nih.gov/gene/?term=5876 GGTB mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017793 5876 RABGGTB http://www.ncbi.nlm.nih.gov/gene/?term=5876 GGTB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017794 5877 RABIF http://www.ncbi.nlm.nih.gov/gene/?term=5877 "MSS4, RASGFR3, RASGRF3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017795 5877 RABIF http://www.ncbi.nlm.nih.gov/gene/?term=5877 "MSS4, RASGFR3, RASGRF3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017796 5878 RAB5C http://www.ncbi.nlm.nih.gov/gene/?term=5878 "L1880L, RAB5L, RABL, RAB5C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017797 5878 RAB5C http://www.ncbi.nlm.nih.gov/gene/?term=5878 "L1880L, RAB5L, RABL, RAB5C " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017798 5878 RAB5C http://www.ncbi.nlm.nih.gov/gene/?term=5878 "L1880, RAB5CL, RAB5L, RABL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017799 58799 Crbn http://www.ncbi.nlm.nih.gov/gene/?term=58799 "2610203G15Rik, 2900045O07Rik, AF229032, AW108261, piL " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017800 5879 RAC1 http://www.ncbi.nlm.nih.gov/gene/?term=5879 "MIG5, Rac-1, TC-25, p21-Rac1 " mRNA Homo sapiens 23452202 Lamellipodium Lung fibroblast Fluorescence in situ hybridization "Rac1, ArpC2 and β-actin mRNAs co-localize with actively translating ribosomes on lamellipodia. " RLID00017801 5879 RAC1 http://www.ncbi.nlm.nih.gov/gene/?term=5879 "MIG5, Rac-1, TC-25, p21-Rac1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017802 5879 RAC1 http://www.ncbi.nlm.nih.gov/gene/?term=5879 "MIG5, Rac-1, TC-25, p21-Rac1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017803 587 BCAT2 http://www.ncbi.nlm.nih.gov/gene/?term=587 "BCAM, BCATM, BCT2, PP18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017804 587 BCAT2 http://www.ncbi.nlm.nih.gov/gene/?term=587 "BCAM, BCATM, BCT2, PP18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017805 58800 Trpm7 http://www.ncbi.nlm.nih.gov/gene/?term=58800 "2310022G15Rik, 4833414K03Rik, 5033407O22Rik, CHAK, CHAK1, LTrpC-7, Ltpr7, Ltrpc7, TRPPLIK " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017806 58800 Trpm7 http://www.ncbi.nlm.nih.gov/gene/?term=58800 "2310022G15Rik, 4833414K03Rik, 5033407O22Rik, CHAK, CHAK1, LTrpC-7, Ltpr7, Ltrpc7, TRPPLIK " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017807 58804 Cdc42ep5 http://www.ncbi.nlm.nih.gov/gene/?term=58804 "1700027J19Rik, 2010007O02Rik, Borg3, C85526, CEP5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017808 5880 RAC2 http://www.ncbi.nlm.nih.gov/gene/?term=5880 "EN-7, Gx, HSPC022, p21-Rac2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017809 58810 Akr1a1 http://www.ncbi.nlm.nih.gov/gene/?term=58810 "2610201A18Rik, Akr1a4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017810 5881 RAC3 http://www.ncbi.nlm.nih.gov/gene/?term=5881 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017811 5884 RAD17 http://www.ncbi.nlm.nih.gov/gene/?term=5884 "CCYC, HRAD17, R24L, RAD17SP, RAD24 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017812 5885 RAD21 http://www.ncbi.nlm.nih.gov/gene/?term=5885 "CDLS4, HR21, HRAD21, MCD1, NXP1, SCC1, hHR21 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017813 5885 RAD21 http://www.ncbi.nlm.nih.gov/gene/?term=5885 "CDLS4, HR21, HRAD21, MCD1, NXP1, SCC1, hHR21 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017814 5886 RAD23A http://www.ncbi.nlm.nih.gov/gene/?term=5886 "HHR23A, HR23A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017815 5886 RAD23A http://www.ncbi.nlm.nih.gov/gene/?term=5886 "HHR23A, HR23A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017816 5887 RAD23B http://www.ncbi.nlm.nih.gov/gene/?term=5887 "HHR23B, HR23B, P58 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017817 5887 RAD23B http://www.ncbi.nlm.nih.gov/gene/?term=5887 "HHR23B, HR23B, P58 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017818 5887 RAD23B http://www.ncbi.nlm.nih.gov/gene/?term=5887 "HHR23B, HR23B, P58 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017819 58887 Repin1 http://www.ncbi.nlm.nih.gov/gene/?term=58887 "AI425994, Ap4, E430037F08Rik, Zfp-464, Zfp464 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017820 5888 RAD51 http://www.ncbi.nlm.nih.gov/gene/?term=5888 "BRCC5, FANCR, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017821 5889 RAD51C http://www.ncbi.nlm.nih.gov/gene/?term=5889 "BROVCA3, FANCO, R51H3, RAD51L2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017822 58911 Sumf1 http://www.ncbi.nlm.nih.gov/gene/?term=58911 "AA543204, AI463102, AI851573, FGE " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017823 5892 RAD51D http://www.ncbi.nlm.nih.gov/gene/?term=5892 "BROVCA4, R51H3, RAD51L3, TRAD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017824 58940 H2afz http://www.ncbi.nlm.nih.gov/gene/?term=58940 H2A.Z-1 mRNA Rattus norvegicus 25301173 Dendrite Hippocampus In situ hybridization "Figure 2: In situ hybridization reveals species-specific patterns of localization in neuronal dendrites. Fluorescent Microscopy evaluation of biotin-conjugated oligoprobes on paraformaldehyde fixed 14-day cultured rat and mouse cortical neurons hybridized with nine biotin-conjugated oligoprobes detected with streptadivin-Alexa Fluor 568 (Invitrogen). For each probe images set, the small bottom left corner panels represent MAP2 immuno-staining. Scale bar = 20um. (A), Probes against SFRS16, ARHGDIA and HNRPK transcripts show higher dendritic localization in mouse neurons than in rat neurons (Red box). (B), Probes against ZFP410, COMMD3 and RSP6 transcripts show higher dendritic localization in rat neurons than in mouse neurons (Blue box). (C), Probes against UBA52, OLFM1 and H2AFZ transcripts show high dendritic localization in both rat and mouse neurons (Black box). Data are collected from Figure 2. " RLID00017825 5894 RAF1 http://www.ncbi.nlm.nih.gov/gene/?term=5894 "CMD1NN, CRAF, NS5, Raf-1, c-Raf " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017826 58985 IL22RA1 http://www.ncbi.nlm.nih.gov/gene/?term=58985 "CRF2-9, IL22R, IL22R1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017827 5898 RALA http://www.ncbi.nlm.nih.gov/gene/?term=5898 RAL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017828 5898 RALA http://www.ncbi.nlm.nih.gov/gene/?term=5898 RAL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017829 58994 Smpd3 http://www.ncbi.nlm.nih.gov/gene/?term=58994 "4631433G07Rik, AI427456, AW537966, fro, nSMase2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017830 5899 RALB http://www.ncbi.nlm.nih.gov/gene/?term=5899 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017831 5899 RALB http://www.ncbi.nlm.nih.gov/gene/?term=5899 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017832 59002 Wrap73 http://www.ncbi.nlm.nih.gov/gene/?term=59002 "2610044M17Rik, 5330425N03Rik, Dd57, Wdr8 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017833 59004 Pias4 http://www.ncbi.nlm.nih.gov/gene/?term=59004 "PIASY, Pias-gamma, Piasg " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017834 59007 Ngly1 http://www.ncbi.nlm.nih.gov/gene/?term=59007 "1110002C09Rik, PNGase, Png1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017835 59007 Ngly1 http://www.ncbi.nlm.nih.gov/gene/?term=59007 "1110002C09Rik, PNGase, Png1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017836 59008 Anapc5 http://www.ncbi.nlm.nih.gov/gene/?term=59008 "2510006G12Rik, AA408751, AA536819, AA986414, APC5, Anpc5 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017837 5900 RALGDS http://www.ncbi.nlm.nih.gov/gene/?term=5900 "RGDS, RGF, RalGEF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017838 5900 RALGDS http://www.ncbi.nlm.nih.gov/gene/?term=5900 "RGDS, RGF, RalGEF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017839 59013 Hnrnph1 http://www.ncbi.nlm.nih.gov/gene/?term=59013 "AI642080, E430005G16Rik, Hnrnph, Hnrph1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017840 59014 Rrs1 http://www.ncbi.nlm.nih.gov/gene/?term=59014 "5730466A07Rik, AA415037, D1Ertd701e, Rrr " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017841 59015 Nup160 http://www.ncbi.nlm.nih.gov/gene/?term=59015 "160kDa, 2810011M03Rik, AA414952, AU020188, Gtl-13, Gtl1-13, Gtl13, mKIAA0197 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017842 5901 RAN http://www.ncbi.nlm.nih.gov/gene/?term=5901 "ARA24, Gsp1, TC4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017843 5901 RAN http://www.ncbi.nlm.nih.gov/gene/?term=5901 "ARA24, Gsp1, TC4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017844 5901 RAN http://www.ncbi.nlm.nih.gov/gene/?term=5901 "ARA24, Gsp1, TC4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017845 59022 Edf1 http://www.ncbi.nlm.nih.gov/gene/?term=59022 "0610008L11Rik, AA409425 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017846 59025 Usp14 http://www.ncbi.nlm.nih.gov/gene/?term=59025 "2610005K12Rik, 2610037B11Rik, AW107924, C78769, ax, nmf375 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017847 59025 Usp14 http://www.ncbi.nlm.nih.gov/gene/?term=59025 "2610005K12Rik, 2610037B11Rik, AW107924, C78769, ax, nmf375 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017848 59026 Huwe1 http://www.ncbi.nlm.nih.gov/gene/?term=59026 "5430439H10Rik, AU041296, Arf-bp1, C430014N20Rik, C80292, Gm1718, Ib772, LASU1, Mule, Ureb1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017849 59027 Nampt http://www.ncbi.nlm.nih.gov/gene/?term=59027 "1110035O14Rik, AI314458, AI480535, NAmPRTase, Pbef, Pbef1, Visfatin " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017850 59029 Psmd14 http://www.ncbi.nlm.nih.gov/gene/?term=59029 "2610312C03Rik, 3200001M20Rik, AA986732, Pad1, Poh1, rpm11 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017851 59029 Psmd14 http://www.ncbi.nlm.nih.gov/gene/?term=59029 "2610312C03Rik, 3200001M20Rik, AA986732, Pad1, Poh1, rpm11 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017852 5902 RANBP1 http://www.ncbi.nlm.nih.gov/gene/?term=5902 HTF9A mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017853 5902 RANBP1 http://www.ncbi.nlm.nih.gov/gene/?term=5902 HTF9A mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017854 5902 RANBP1 http://www.ncbi.nlm.nih.gov/gene/?term=5902 HTF9A mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017855 59030 Mkks http://www.ncbi.nlm.nih.gov/gene/?term=59030 "1300013E18Rik, AI463362, AI957237, Bbs6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017856 59036 Dact1 http://www.ncbi.nlm.nih.gov/gene/?term=59036 "4921528D17Rik, AI115603, DAPPER, DAPPER1, FRODO, Frd1, Frodo1, MDpr1, MTNG3, THYEX3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017857 59038 Pxmp4 http://www.ncbi.nlm.nih.gov/gene/?term=59038 "3010018P03Rik, Pmp24 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017858 5903 RANBP2 http://www.ncbi.nlm.nih.gov/gene/?term=5903 "ADANE, ANE1, IIAE3, NUP358, TRP1, TRP2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017859 5903 RANBP2 http://www.ncbi.nlm.nih.gov/gene/?term=5903 "ADANE, ANE1, IIAE3, NUP358, TRP1, TRP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017860 59040 Rhot1 http://www.ncbi.nlm.nih.gov/gene/?term=59040 "2210403N23Rik, AA415293, AF244542, AI834919, Arht1, C430039G08Rik, Miro1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017861 59044 Rnf130 http://www.ncbi.nlm.nih.gov/gene/?term=59044 "2510042A13Rik, G1RZFP, G1rp, GOLIATH, GP " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017862 59050 Nsa2 http://www.ncbi.nlm.nih.gov/gene/?term=59050 "5730427N09Rik, LNR42p, Tinp1, Yr29, Nsa2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017863 59052 Mettl9 http://www.ncbi.nlm.nih.gov/gene/?term=59052 "0610012D09Rik, AA517660, Drev, MNCb-5680 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017864 59053 Hgh1 http://www.ncbi.nlm.nih.gov/gene/?term=59053 "Brp16, D15Ertd741e, Fam203a, MNCb-5873 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017865 59058 Bhlhe22 http://www.ncbi.nlm.nih.gov/gene/?term=59058 "Beta3, Bhlhb5 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017866 5905 RANGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=5905 "Fug1, RANGAP, SD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017867 5905 RANGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=5905 "Fug1, RANGAP, SD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017868 5905 RANGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=5905 "Fug1, RANGAP, SD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017869 59069 Tpm3 http://www.ncbi.nlm.nih.gov/gene/?term=59069 "TM30nm, TMnm, Tm5NM, Tpm-5, Tpm5, Trop-5, gamma-TM, hTM30nm, hTMnm " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00017870 5906 RAP1A http://www.ncbi.nlm.nih.gov/gene/?term=5906 "C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017871 59079 Erbb2ip http://www.ncbi.nlm.nih.gov/gene/?term=59079 "1700028E05Rik, Erbin, mKIAA1225 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017872 59082 CARD18 http://www.ncbi.nlm.nih.gov/gene/?term=59082 "ICEBERG, UNQ5804, pseudo-ICE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017873 59085 Asl http://www.ncbi.nlm.nih.gov/gene/?term=59085 mRNA Rattus norvegicus 8726358 Mitochondrion Liver In situ hybridization "These ratios showed that the mRNAs for argininosuccinate synthetase and argininosuccinate lyase were located next to the cytoplasmic side of the mitochondrial membrane and in the nearby endoplasmic reticulum. These data show that ASL mRNA is preferentially located at the mitochondrial outer membrane and in the ER. Thus,ASS mRNA, likeASL mRNA, is preferentially located at the mitochondrial outer membrane and in the ER. This suggests that COIII mRNA is actually predominantly associated with those portions of the inner membrane which lie at the mitochondrial perimeter rather than along the cristae. " RLID00017874 59085 Asl http://www.ncbi.nlm.nih.gov/gene/?term=59085 mRNA Rattus norvegicus 8726358 Endoplasmic reticulum Liver In situ hybridization "These ratios showed that the mRNAs for argininosuccinate synthetase and argininosuccinate lyase were located next to the cytoplasmic side of the mitochondrial membrane and in the nearby endoplasmic reticulum. These data show that ASL mRNA is preferentially located at the mitochondrial outer membrane and in the ER. Thus,ASS mRNA, likeASL mRNA, is preferentially located at the mitochondrial outer membrane and in the ER. This suggests that COIII mRNA is actually predominantly associated with those portions of the inner membrane which lie at the mitochondrial perimeter rather than along the cristae. " RLID00017875 5908 RAP1B http://www.ncbi.nlm.nih.gov/gene/?term=5908 "K-REV, RAL1B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017876 5908 RAP1B http://www.ncbi.nlm.nih.gov/gene/?term=5908 "K-REV, RAL1B " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017877 5908 RAP1B http://www.ncbi.nlm.nih.gov/gene/?term=5908 "K-REV, RAL1B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017878 5909 RAP1GAP http://www.ncbi.nlm.nih.gov/gene/?term=5909 "RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017879 590 BCHE http://www.ncbi.nlm.nih.gov/gene/?term=590 "CHE1, CHE2, E1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017880 5910 RAP1GDS1 http://www.ncbi.nlm.nih.gov/gene/?term=5910 "GDS1, SmgGDS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017881 5910 RAP1GDS1 http://www.ncbi.nlm.nih.gov/gene/?term=5910 "GDS1, SmgGDS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017882 5911 RAP2A http://www.ncbi.nlm.nih.gov/gene/?term=5911 "K-REV, KREV, RAP2, RbBP-30 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017883 5911 RAP2A http://www.ncbi.nlm.nih.gov/gene/?term=5911 "K-REV, KREV, RAP2, RbBP-30 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017884 59126 Nek6 http://www.ncbi.nlm.nih.gov/gene/?term=59126 1300007C09Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00017885 5912 RAP2B http://www.ncbi.nlm.nih.gov/gene/?term=5912 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017886 59170 CG18809 http://www.ncbi.nlm.nih.gov/gene/?term=59170 "Dmel_ CG1809, Dmel\CG18809 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00017887 5917 RARS http://www.ncbi.nlm.nih.gov/gene/?term=5917 "ArgRS, DALRD1, HLD9 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017888 5917 RARS http://www.ncbi.nlm.nih.gov/gene/?term=5917 "ArgRS, DALRD1, HLD9 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017889 5917 RARS http://www.ncbi.nlm.nih.gov/gene/?term=5917 "ArgRS, DALRD1, HLD9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017890 5924 RASGRF2 http://www.ncbi.nlm.nih.gov/gene/?term=5924 "GRF2, RAS-GRF2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017891 59253 CG18508 http://www.ncbi.nlm.nih.gov/gene/?term=59253 "Dmel_ CG4015, Dmel\CG18508, EG:140G11.3 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00017892 59253 CG18508 http://www.ncbi.nlm.nih.gov/gene/?term=59253 "Dmel_ CG4015, Dmel\CG18508, EG:140G11.3 " mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00017893 5925 RB1 http://www.ncbi.nlm.nih.gov/gene/?term=5925 "OSRC, PPP1R130, RB, p105-Rb, pRb, pp110 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017894 59266 Hcn4 http://www.ncbi.nlm.nih.gov/gene/?term=59266 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00017895 59271 EVA1C http://www.ncbi.nlm.nih.gov/gene/?term=59271 "B18, B19, C21orf63, C21orf64, FAM176C, PRED34, SUE21 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017896 59274 MESDC1 http://www.ncbi.nlm.nih.gov/gene/?term=59274 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017897 59274 MESDC1 http://www.ncbi.nlm.nih.gov/gene/?term=59274 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017898 59277 NTN4 http://www.ncbi.nlm.nih.gov/gene/?term=59277 PRO3091 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017899 5927 KDM5A http://www.ncbi.nlm.nih.gov/gene/?term=5927 "RBBP-2, RBBP2, RBP2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017900 5927 KDM5A http://www.ncbi.nlm.nih.gov/gene/?term=5927 "RBBP-2, RBBP2, RBP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017901 59286 UBL5 http://www.ncbi.nlm.nih.gov/gene/?term=59286 HUB1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017902 59286 UBL5 http://www.ncbi.nlm.nih.gov/gene/?term=59286 HUB1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017903 59286 UBL5 http://www.ncbi.nlm.nih.gov/gene/?term=59286 HUB1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017904 5928 RBBP4 http://www.ncbi.nlm.nih.gov/gene/?term=5928 "NURF55, RBAP48, lin-53 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017905 5928 RBBP4 http://www.ncbi.nlm.nih.gov/gene/?term=5928 "NURF55, RBAP48, lin-53 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017906 5928 RBBP4 http://www.ncbi.nlm.nih.gov/gene/?term=5928 "NURF55, RBAP48, lin-53 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017907 5928 RBBP4 http://www.ncbi.nlm.nih.gov/gene/?term=5928 "NURF55, RBAP48, lin-53 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017908 59307 SIGIRR http://www.ncbi.nlm.nih.gov/gene/?term=59307 TIR8 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017909 5930 RBBP6 http://www.ncbi.nlm.nih.gov/gene/?term=5930 "MY038, P2P-R, PACT, RBQ-1, SNAMA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017910 5931 RBBP7 http://www.ncbi.nlm.nih.gov/gene/?term=5931 RbAp46 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017911 59338 PLEKHA1 http://www.ncbi.nlm.nih.gov/gene/?term=59338 TAPP1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017912 59338 PLEKHA1 http://www.ncbi.nlm.nih.gov/gene/?term=59338 TAPP1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017913 59338 PLEKHA1 http://www.ncbi.nlm.nih.gov/gene/?term=59338 TAPP1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017914 59339 PLEKHA2 http://www.ncbi.nlm.nih.gov/gene/?term=59339 TAPP2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017915 59339 PLEKHA2 http://www.ncbi.nlm.nih.gov/gene/?term=59339 TAPP2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017916 59339 PLEKHA2 http://www.ncbi.nlm.nih.gov/gene/?term=59339 TAPP2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017917 59339 PLEKHA2 http://www.ncbi.nlm.nih.gov/gene/?term=59339 TAPP2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017918 5933 RBL1 http://www.ncbi.nlm.nih.gov/gene/?term=5933 "CP107, PRB1, p107 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017919 59342 SCPEP1 http://www.ncbi.nlm.nih.gov/gene/?term=59342 "HSCP1, RISC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017920 59342 SCPEP1 http://www.ncbi.nlm.nih.gov/gene/?term=59342 "HSCP1, RISC " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017921 59343 SENP2 http://www.ncbi.nlm.nih.gov/gene/?term=59343 "AXAM2, SMT3IP2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017922 59343 SENP2 http://www.ncbi.nlm.nih.gov/gene/?term=59343 "AXAM2, SMT3IP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017923 59345 GNB4 http://www.ncbi.nlm.nih.gov/gene/?term=59345 CMTD1F mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017924 59348 ZNF350 http://www.ncbi.nlm.nih.gov/gene/?term=59348 "ZBRK1, ZFQR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017925 59348 ZNF350 http://www.ncbi.nlm.nih.gov/gene/?term=59348 "ZBRK1, ZFQR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017926 59349 KLHL12 http://www.ncbi.nlm.nih.gov/gene/?term=59349 "C3IP1, DKIR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017927 5934 RBL2 http://www.ncbi.nlm.nih.gov/gene/?term=5934 "P130, Rb2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017928 5935 RBM3 http://www.ncbi.nlm.nih.gov/gene/?term=5935 "IS1-RNPL, RNPL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017929 5935 RBM3 http://www.ncbi.nlm.nih.gov/gene/?term=5935 "IS1-RNPL, RNPL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017930 5936 RBM4 http://www.ncbi.nlm.nih.gov/gene/?term=5936 "LARKA, ZCCHC21, ZCRB3A, RBM4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017931 5936 RBM4 http://www.ncbi.nlm.nih.gov/gene/?term=5936 "LARK, RBM4A, ZCCHC21, ZCRB3A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017932 5939 RBMS2 http://www.ncbi.nlm.nih.gov/gene/?term=5939 SCR3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017933 593 BCKDHA http://www.ncbi.nlm.nih.gov/gene/?term=593 "BCKDE1A, MSU, MSUD1, OVD1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017934 594837 SNORD101 http://www.ncbi.nlm.nih.gov/gene/?term=594837 U101 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017935 594837 SNORD101 http://www.ncbi.nlm.nih.gov/gene/?term=594837 U101 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017936 594837 SNORD101 http://www.ncbi.nlm.nih.gov/gene/?term=594837 U101 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017937 594838 SNORD100 http://www.ncbi.nlm.nih.gov/gene/?term=594838 HBII-429 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00017938 594838 SNORD100 http://www.ncbi.nlm.nih.gov/gene/?term=594838 HBII-429 snoRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "The most abundant snoRNA found in the serum exosomes were SNORD100, SNORD27 and SNORD31 (Supplementary file). The functions of these snoRNA species are largely unknown; however, they have been detected in myeloma. " RLID00017939 594838 SNORD100 http://www.ncbi.nlm.nih.gov/gene/?term=594838 HBII-429 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017940 594838 SNORD100 http://www.ncbi.nlm.nih.gov/gene/?term=594838 HBII-429 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00017941 594838 SNORD100 http://www.ncbi.nlm.nih.gov/gene/?term=594838 HBII-429 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00017942 594838 SNORD100 http://www.ncbi.nlm.nih.gov/gene/?term=594838 HBII-429 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017943 594838 SNORD100 http://www.ncbi.nlm.nih.gov/gene/?term=594838 HBII-429 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017944 594839 SNORA33 http://www.ncbi.nlm.nih.gov/gene/?term=594839 ACA33 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017945 594839 SNORA33 http://www.ncbi.nlm.nih.gov/gene/?term=594839 ACA33 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017946 5949 RBP3 http://www.ncbi.nlm.nih.gov/gene/?term=5949 "D10S64, D10S65, D10S66, IRBP, RBPI, RP66 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017947 594 BCKDHB http://www.ncbi.nlm.nih.gov/gene/?term=594 "BCKDE1B, BCKDH E1-beta, E1B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017948 594 BCKDHB http://www.ncbi.nlm.nih.gov/gene/?term=594 "BCKDE1B, BCKDH E1-beta, E1B " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017949 594 BCKDHB http://www.ncbi.nlm.nih.gov/gene/?term=594 "BCKDE1B, BCKDH E1-beta, E1B " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017950 595097 SNORD16 http://www.ncbi.nlm.nih.gov/gene/?term=595097 U16 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017951 595097 SNORD16 http://www.ncbi.nlm.nih.gov/gene/?term=595097 U16 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017952 595098 SNORD18A http://www.ncbi.nlm.nih.gov/gene/?term=595098 U18A snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00017953 5954 RCN1 http://www.ncbi.nlm.nih.gov/gene/?term=5954 "HEL-S-84, PIG20, RCAL, RCN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017954 5954 RCN1 http://www.ncbi.nlm.nih.gov/gene/?term=5954 "HEL-S-84, PIG20, RCAL, RCN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017955 5955 RCN2 http://www.ncbi.nlm.nih.gov/gene/?term=5955 "E6BP, ERC-55, ERC55, TCBP49 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017956 5955 RCN2 http://www.ncbi.nlm.nih.gov/gene/?term=5955 "E6BP, ERC-55, ERC55, TCBP49 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017957 5959 RDH5 http://www.ncbi.nlm.nih.gov/gene/?term=5959 "9cRDH, HSD17B9, RDH1, SDR9C5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017958 595 CCND1 http://www.ncbi.nlm.nih.gov/gene/?term=595 "BCL1, D11S287E, PRAD1, U21B31 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017959 595 CCND1 http://www.ncbi.nlm.nih.gov/gene/?term=595 "BCL1, D11S287E, PRAD1, U21B31 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017960 5962 RDX http://www.ncbi.nlm.nih.gov/gene/?term=5962 DFNB24 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017961 5962 RDX http://www.ncbi.nlm.nih.gov/gene/?term=5962 DFNB24 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017962 5965 RECQL http://www.ncbi.nlm.nih.gov/gene/?term=5965 "RECQL1, RecQ1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017963 5966 REL http://www.ncbi.nlm.nih.gov/gene/?term=5966 C-Rel mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017964 5967 REG1A http://www.ncbi.nlm.nih.gov/gene/?term=5967 "ICRF, P19, PSP, PSPS, PSPS1, PTP, REG " mRNA Homo sapiens 26000482 Ribosome HeLa cell qRT-PCR "To further investigate whether Reg1 localizes to translationally active polysomes, HeLa cell lysates were subjected to polysome fractionations ( Figure 3 E). Immunoblot analysis revealed that endogenous Reg1 localized in polysomal fractions in addition to non-polysome (non-ribosome and 40S-80S) fractions ( Fig- ure 3 E), though Roquin-1 and -2 were localized in the non-poly- some fractions. " RLID00017965 596 BCL2 http://www.ncbi.nlm.nih.gov/gene/?term=596 "Bcl-2, PPP1R50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017966 5970 RELA http://www.ncbi.nlm.nih.gov/gene/?term=5970 "NFKB3, p65 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017967 5970 RELA http://www.ncbi.nlm.nih.gov/gene/?term=5970 "NFKB3, p65 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017968 5971 RELB http://www.ncbi.nlm.nih.gov/gene/?term=5971 "I-REL, IREL, REL-B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017969 5972 REN http://www.ncbi.nlm.nih.gov/gene/?term=5972 HNFJ2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017970 5976 UPF1 http://www.ncbi.nlm.nih.gov/gene/?term=5976 "HUPF1, NORF1, RENT1, pNORF1, smg-2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017971 5976 UPF1 http://www.ncbi.nlm.nih.gov/gene/?term=5976 "HUPF1, NORF1, RENT1, pNORF1, smg-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017972 5976 UPF1 http://www.ncbi.nlm.nih.gov/gene/?term=5976 "HUPF1, NORF1, RENT1, pNORF1, smg-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017973 5977 DPF2 http://www.ncbi.nlm.nih.gov/gene/?term=5977 "REQ, UBID4, ubi-d4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017974 5977 DPF2 http://www.ncbi.nlm.nih.gov/gene/?term=5977 "REQ, UBID4, ubi-d4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017975 5977 DPF2 http://www.ncbi.nlm.nih.gov/gene/?term=5977 "REQ, UBID4, ubi-d4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017976 5978 REST http://www.ncbi.nlm.nih.gov/gene/?term=5978 "NRSF, WT6, XBR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017977 5978 REST http://www.ncbi.nlm.nih.gov/gene/?term=5978 "NRSF, WT6, XBR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017978 5978 REST http://www.ncbi.nlm.nih.gov/gene/?term=5978 "NRSF, WT6, XBR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017979 5979 RET http://www.ncbi.nlm.nih.gov/gene/?term=5979 "CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017980 5980 REV3L http://www.ncbi.nlm.nih.gov/gene/?term=5980 "POLZ, REV3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017981 5981 RFC1 http://www.ncbi.nlm.nih.gov/gene/?term=5981 "A1, MHCBFB, PO-GA, RECC1, RFC40, RFC1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017982 5981 RFC1 http://www.ncbi.nlm.nih.gov/gene/?term=5981 "A1, MHCBFB, PO-GA, RECC1, RFC, RFC140 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017983 5982 RFC2 http://www.ncbi.nlm.nih.gov/gene/?term=5982 RFC40 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017984 5983 RFC3 http://www.ncbi.nlm.nih.gov/gene/?term=5983 RFC38 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017985 5983 RFC3 http://www.ncbi.nlm.nih.gov/gene/?term=5983 RFC38 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017986 5984 RFC4 http://www.ncbi.nlm.nih.gov/gene/?term=5984 "A1, RFC37 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017987 5984 RFC4 http://www.ncbi.nlm.nih.gov/gene/?term=5984 "A1, RFC37 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017988 5985 RFC5 http://www.ncbi.nlm.nih.gov/gene/?term=5985 RFC36 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017989 5986 RFNG http://www.ncbi.nlm.nih.gov/gene/?term=5986 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017990 5987 TRIM27 http://www.ncbi.nlm.nih.gov/gene/?term=5987 "RFP, RNF76 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017991 5987 TRIM27 http://www.ncbi.nlm.nih.gov/gene/?term=5987 "RFP, RNF76 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00017992 5987 TRIM27 http://www.ncbi.nlm.nih.gov/gene/?term=5987 "RFP, RNF76 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017993 5989 RFX1 http://www.ncbi.nlm.nih.gov/gene/?term=5989 "EFC, RFX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017994 5990 RFX2 http://www.ncbi.nlm.nih.gov/gene/?term=5990 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017995 5993 RFX5 http://www.ncbi.nlm.nih.gov/gene/?term=5993 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017996 5994 RFXAP http://www.ncbi.nlm.nih.gov/gene/?term=5994 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00017997 5997 RGS2 http://www.ncbi.nlm.nih.gov/gene/?term=5997 G0S8 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00017998 5998 RGS3 http://www.ncbi.nlm.nih.gov/gene/?term=5998 "C2PA, RGP3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00017999 5998 RGS3 http://www.ncbi.nlm.nih.gov/gene/?term=5998 "C2PA, RGP3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018000 5998 RGS3 http://www.ncbi.nlm.nih.gov/gene/?term=5998 "C2PA, RGP3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018001 599 BCL2L2 http://www.ncbi.nlm.nih.gov/gene/?term=599 "BCL-W, BCL2-L-2, BCLW, PPP1R51 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018002 59 ACTA2 http://www.ncbi.nlm.nih.gov/gene/?term=59 "AAT6, ACTSA, MYMY5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018003 59 ACTA2 http://www.ncbi.nlm.nih.gov/gene/?term=59 "AAT6, ACTSA, MYMY5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018004 6001 RGS10 http://www.ncbi.nlm.nih.gov/gene/?term=6001 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018005 6001 RGS10 http://www.ncbi.nlm.nih.gov/gene/?term=6001 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018006 6002 RGS12 http://www.ncbi.nlm.nih.gov/gene/?term=6002 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018007 6002 RGS12 http://www.ncbi.nlm.nih.gov/gene/?term=6002 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018008 6002 RGS12 http://www.ncbi.nlm.nih.gov/gene/?term=6002 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018009 6004 RGS16 http://www.ncbi.nlm.nih.gov/gene/?term=6004 "A28-RGS14, A28-RGS14P, RGS-R " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018010 6005 RHAG http://www.ncbi.nlm.nih.gov/gene/?term=6005 "CD241, OHS, RH2, RH50A, Rh50, Rh50GP, SLC42A1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018011 6006 RHCE http://www.ncbi.nlm.nih.gov/gene/?term=6006 "CD240CE, RH, RH30A, RHC, RHE, RHIXB, RHPI, Rh4, RhIVb(J), RhVI, RhVIII " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018012 6007 RHD http://www.ncbi.nlm.nih.gov/gene/?term=6007 "CD240D, DIIIc, RH, RH30, RHCEDVA(TT), RHDel, RHPII, RHXIII, Rh4, RhDCw, RhII, RhK562-II, RhPI, RHD " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018013 6007 RHD http://www.ncbi.nlm.nih.gov/gene/?term=6007 "CD240D, DIIIc, RH, RH30, RHCEDVA(TT), RHDel, RHPII, RHXIII, Rh4, RhDCw, RhII, RhK562-II, RhPI, RHD " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018014 6007 RHD http://www.ncbi.nlm.nih.gov/gene/?term=6007 "CD240D, DIIIc, RH, RH30, RHCED, RHDVA(TT), RHDel, RHPII, RHXIII, Rh4, RhDCw, RhII, RhK562-II, RhPI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018015 6009 RHEB http://www.ncbi.nlm.nih.gov/gene/?term=6009 RHEB2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018016 6009 RHEB http://www.ncbi.nlm.nih.gov/gene/?term=6009 RHEB2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018017 6010 RHO http://www.ncbi.nlm.nih.gov/gene/?term=6010 "CSNBAD1, OPN2, RP4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018018 6015 RING1 http://www.ncbi.nlm.nih.gov/gene/?term=6015 "RING1A, RNF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018019 6015 RING1 http://www.ncbi.nlm.nih.gov/gene/?term=6015 "RING1A, RNF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018020 6016 RIT1 http://www.ncbi.nlm.nih.gov/gene/?term=6016 "NS8, RIBB, RIT, ROC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018021 6018 RLF http://www.ncbi.nlm.nih.gov/gene/?term=6018 "ZN-15L, ZNF292L " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018022 6018 RLF http://www.ncbi.nlm.nih.gov/gene/?term=6018 "ZN-15L, ZNF292L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018023 6023 RMRP http://www.ncbi.nlm.nih.gov/gene/?term=6023 "CHH, NME1R, RRP2, RMRP " lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018024 6023 RMRP http://www.ncbi.nlm.nih.gov/gene/?term=6023 "CHH, NME1R, RRP2, RMRP " lncRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00018025 6029 RN7SL1 http://www.ncbi.nlm.nih.gov/gene/?term=6029 "7L1a, 7SL, RN7SL, RNSRP1 " lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018026 6029 RN7SL1 http://www.ncbi.nlm.nih.gov/gene/?term=6029 "7L1a, 7SL, RN7SL, RNSRP1 " lncRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00018027 60312 AFAP1 http://www.ncbi.nlm.nih.gov/gene/?term=60312 "AFAP, AFAP-11010, AFAP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018028 60313 GPBP1L1 http://www.ncbi.nlm.nih.gov/gene/?term=60313 SP192 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018029 60343 FAM3A http://www.ncbi.nlm.nih.gov/gene/?term=60343 "2.19, DLD, DXS560S, XAP-7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018030 60343 FAM3A http://www.ncbi.nlm.nih.gov/gene/?term=60343 "2.19, DLD, DXS560S, XAP-7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018031 60344 Fign http://www.ncbi.nlm.nih.gov/gene/?term=60344 "fi, fidget " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018032 6035 RNASE1 http://www.ncbi.nlm.nih.gov/gene/?term=6035 "RAC1, RIB1, RNS1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018033 60364 Donson http://www.ncbi.nlm.nih.gov/gene/?term=60364 "1110025J21Rik, AI845729, ORF60 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018034 60370 AVPI1 http://www.ncbi.nlm.nih.gov/gene/?term=60370 "PP5395, VIP32, VIT32 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018035 60386 SLC25A19 http://www.ncbi.nlm.nih.gov/gene/?term=60386 "DNC, MCPHA, MUP1, THMD3, THMD4, TPC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018036 6039 RNASE6 http://www.ncbi.nlm.nih.gov/gene/?term=6039 "RAD1, RNS6, RNasek6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018037 60412 EXOC4 http://www.ncbi.nlm.nih.gov/gene/?term=60412 "SEC8, SEC8L1, Sec8p " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018038 60425 Doc2g http://www.ncbi.nlm.nih.gov/gene/?term=60425 D830013O18Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018039 60436 TGIF2 http://www.ncbi.nlm.nih.gov/gene/?term=60436 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018040 60436 TGIF2 http://www.ncbi.nlm.nih.gov/gene/?term=60436 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018041 6043 SNORA63 http://www.ncbi.nlm.nih.gov/gene/?term=6043 "E3, E3-2, RNE3, RNU107A, elF-4AII, SNORA63 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018042 6043 SNORA63 http://www.ncbi.nlm.nih.gov/gene/?term=6043 "E3, E3-2, RNE3, RNU107A, elF-4AII, SNORA63 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018043 60440 Iigp1 http://www.ncbi.nlm.nih.gov/gene/?term=60440 "2900074L10Rik, AI046432, AW111922, Ifgga1, Iigp, Irga6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018044 6045 RNF2 http://www.ncbi.nlm.nih.gov/gene/?term=6045 "BAP-1, BAP1, DING, HIPI3, RING1B, RING2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018045 6046 BRD2 http://www.ncbi.nlm.nih.gov/gene/?term=6046 "D6S113E, FSH, FSRG1, NAT, O27.1.1, RING3, RNF3 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018046 6046 BRD2 http://www.ncbi.nlm.nih.gov/gene/?term=6046 "D6S113E, FSH, FSRG1, NAT, O27.1.1, RING3, RNF3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018047 6046 BRD2 http://www.ncbi.nlm.nih.gov/gene/?term=6046 "D6S113E, FSH, FSRG1, NAT, O27.1.1, RING3, RNF3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018048 6046 BRD2 http://www.ncbi.nlm.nih.gov/gene/?term=6046 "D6S113E, FSH, FSRG1, NAT, O27.1.1, RING3, RNF3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018049 6046 BRD2 http://www.ncbi.nlm.nih.gov/gene/?term=6046 "D6S113E, FSH, FSRG1, NAT, O27.1.1, RING3, RNF3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018050 6047 RNF4 http://www.ncbi.nlm.nih.gov/gene/?term=6047 "RES4-26, SLX5, SNURF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018051 6047 RNF4 http://www.ncbi.nlm.nih.gov/gene/?term=6047 "RES4-26, SLX5, SNURF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018052 6047 RNF4 http://www.ncbi.nlm.nih.gov/gene/?term=6047 "RES4-26, SLX5, SNURF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018053 60481 ELOVL5 http://www.ncbi.nlm.nih.gov/gene/?term=60481 "HELO1, SCA38, dJ483K16.1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018054 60481 ELOVL5 http://www.ncbi.nlm.nih.gov/gene/?term=60481 "HELO1, SCA38, dJ483K16.1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018055 60481 ELOVL5 http://www.ncbi.nlm.nih.gov/gene/?term=60481 "HELO1, SCA38, dJ483K16.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018056 60485 SAV1 http://www.ncbi.nlm.nih.gov/gene/?term=60485 "SAV, WW45, WWP4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018057 60487 TRMT11 http://www.ncbi.nlm.nih.gov/gene/?term=60487 "C6orf75, MDS024, TRM11, TRMT11-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018058 60488 MRPS35 http://www.ncbi.nlm.nih.gov/gene/?term=60488 "HDCMD11P, MDS023, MRP-S28, MRPS28 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018059 60488 MRPS35 http://www.ncbi.nlm.nih.gov/gene/?term=60488 "HDCMD11P, MDS023, MRP-S28, MRPS28 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018060 60489 APOBEC3G http://www.ncbi.nlm.nih.gov/gene/?term=60489 "A3G, ARCD, ARP-9, ARP9, CEM-15, CEM15, MDS019, bK150C2.7, dJ494G10.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018061 6048 RNF5 http://www.ncbi.nlm.nih.gov/gene/?term=6048 "RING5, RMA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018062 60490 PPCDC http://www.ncbi.nlm.nih.gov/gene/?term=60490 "MDS018, PPC-DC, coaC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018063 60491 NIF3L1 http://www.ncbi.nlm.nih.gov/gene/?term=60491 "ALS2CR1, CALS-7, MDS015 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018064 60492 CCDC90B http://www.ncbi.nlm.nih.gov/gene/?term=60492 "MDS011, MDS025 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018065 60496 AASDHPPT http://www.ncbi.nlm.nih.gov/gene/?term=60496 "AASD-PPT, ACPS, CGI-80, LYS2, LYS5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018066 6049 RNF6 http://www.ncbi.nlm.nih.gov/gene/?term=6049 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018067 604 BCL6 http://www.ncbi.nlm.nih.gov/gene/?term=604 "BCL5, BCL6A, LAZ3, ZBTB27, ZNF51 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018068 60509 AGBL5 http://www.ncbi.nlm.nih.gov/gene/?term=60509 CCP5 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018069 6050 RNH1 http://www.ncbi.nlm.nih.gov/gene/?term=6050 "RAI, RNH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018070 6050 RNH1 http://www.ncbi.nlm.nih.gov/gene/?term=6050 "RAI, RNH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018071 6051 RNPEP http://www.ncbi.nlm.nih.gov/gene/?term=6051 AP-B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018072 6051 RNPEP http://www.ncbi.nlm.nih.gov/gene/?term=6051 AP-B mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018073 6051 RNPEP http://www.ncbi.nlm.nih.gov/gene/?term=6051 AP-B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018074 60526 LDAH http://www.ncbi.nlm.nih.gov/gene/?term=60526 "C2orf43, hLDAH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018075 60526 LDAH http://www.ncbi.nlm.nih.gov/gene/?term=60526 "C2orf43, hLDAH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018076 60528 ELAC2 http://www.ncbi.nlm.nih.gov/gene/?term=60528 "COXPD17, ELC2, HPC2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018077 60532 Wtap http://www.ncbi.nlm.nih.gov/gene/?term=60532 "2810408K05Rik, 9430038B09Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018078 60532 Wtap http://www.ncbi.nlm.nih.gov/gene/?term=60532 "2810408K05Rik, 9430038B09Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00018079 60532 Wtap http://www.ncbi.nlm.nih.gov/gene/?term=60532 "2810408K05Rik, 9430038B09Rik " mRNA Mus musculus 26190105 Nucleus Embryotem cell Microscopy "Figure 6: 3DSIM Showing that Xist RNA, Rbm15, Wtap, and Spen Co-localize within Perichromatin Spaces. Data are collected from Figure 6. " RLID00018080 60558 GUF1 http://www.ncbi.nlm.nih.gov/gene/?term=60558 EF-4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018081 60559 SPCS3 http://www.ncbi.nlm.nih.gov/gene/?term=60559 "PRO3567, SPC22/23, SPC3, YLR066W " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018082 60559 SPCS3 http://www.ncbi.nlm.nih.gov/gene/?term=60559 "PRO3567, SPC22/23, SPC3, YLR066W " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018083 60560 NAA35 http://www.ncbi.nlm.nih.gov/gene/?term=60560 "EGAP, MAK10, MAK10P, bA379P1.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018084 60592 SCOC http://www.ncbi.nlm.nih.gov/gene/?term=60592 "HRIHFB2072O, UNC-69, SCOC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018085 60597 Mapk8ip2 http://www.ncbi.nlm.nih.gov/gene/?term=60597 "3230402N03Rik, AI847694, AW049958, IB2, Jip2, R75148 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018086 60599 Trp53inp1 http://www.ncbi.nlm.nih.gov/gene/?term=60599 "2700057G22Rik, SIP, SIP18, SIP27, Stinp, Teap " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00018087 6059 ABCE1 http://www.ncbi.nlm.nih.gov/gene/?term=6059 "ABC38, OABP, RLI, RNASEL1, RNASELI, RNS4I " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018088 6059 ABCE1 http://www.ncbi.nlm.nih.gov/gene/?term=6059 "ABC38, OABP, RLI, RNASEL1, RNASELI, RNS4I " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018089 6059 ABCE1 http://www.ncbi.nlm.nih.gov/gene/?term=6059 "ABC38, OABP, RLI, RNASEL1, RNASELI, RNS4I " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018090 6060 RNU1-4 http://www.ncbi.nlm.nih.gov/gene/?term=6060 "HSD2, HSD5, HSD6, HSD7, RNU1, RNU1D2, RNU1E2, RNU1F1, RNU1G1, RNU1G2, U1B2, U1D2, U1E2, U1F " snRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00018091 6060 RNU1-4 http://www.ncbi.nlm.nih.gov/gene/?term=6060 "HSD2, HSD5, HSD6, HSD7, RNU1, RNU1D2, RNU1E2, RNU1F1, RNU1G1, RNU1G2, U1B2, U1D2, U1E2, U1F " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018092 60625 DHX35 http://www.ncbi.nlm.nih.gov/gene/?term=60625 "C20orf15, DDX35, KAIA0875 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018093 60626 RIC8A http://www.ncbi.nlm.nih.gov/gene/?term=60626 RIC8 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018094 606495 CYB5RL http://www.ncbi.nlm.nih.gov/gene/?term=606495 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018095 606496 Gsk3a http://www.ncbi.nlm.nih.gov/gene/?term=606496 2700086H06Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018096 606497 Otx2os1 http://www.ncbi.nlm.nih.gov/gene/?term=606497 lncRNA Mus musculus 15703187 Nucleus Embryonic tissue In situ hybridization|RT-PCR "We detected the expression in adult retina (postnatal day 30, P30) of Six3OS, Six6OS, Otx2OS, CrxOS and RaxOS (Fig. 3 and data not shown). In general, these transcripts were all expressed at higher levels in the inner nuclear layer (INL) and in the ganglion cell layer (GCL). " RLID00018097 606497 Otx2os1 http://www.ncbi.nlm.nih.gov/gene/?term=606497 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018098 606500 SNORD68 http://www.ncbi.nlm.nih.gov/gene/?term=606500 HBII-202 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00018099 606500 SNORD68 http://www.ncbi.nlm.nih.gov/gene/?term=606500 HBII-202 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018100 606500 SNORD68 http://www.ncbi.nlm.nih.gov/gene/?term=606500 HBII-202 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018101 60658 nos1 http://www.ncbi.nlm.nih.gov/gene/?term=60658 "nNOS, nos " mRNA Danio rerio 16457796 Germ plasm Embryo Fluorescence in situ hybridization "Fig. 1. Endogenous patterns of RNA localization of dnd, nos1, vas, and dazl RNAs during the first cell cycle. Animal views of embryos fixed at progressively older stages of development (A-D: 15 min p.f.; E-H: 30 min. p.f.; I-L: 45 min p.f.) and labeled using FISH to detect germ plasm RNAs (dnd (A, E, I); nos1 (B, F, J); vas(C,G, K); dazl (D, H, L). (A-D) Immediately after fertilization, dnd, nos1, and vas RNA aggregates can be observed as a band at the animal pole, while dazl RNA aggregates are not initially present in the animal pole. (E-H) During the initiation of furrow formation, RNA aggregates fordnd, nos1, and vas begin to be recruited as a rod at the forming furrow (arrows in E-G). At this stage, dazl RNA is not yet detectable at the furrows (H). (I-L) As the furrow matures, there is an increase in the amount of dnd, nos1, and vasRNAs recruited at the furrow, and dazlRNA becomes detectable at the furrow (arrows in I-L). Scale bar in panel (L) represents 100 μmThus, although all four RNAs are recruited to the forming furrow, RNAs for dnd, nos1, and vas are already present in the animal pole in the freshly laid egg, while dazlRNA arrives to the animal pole from the vegetal region at a later stage. Based on their different times of appearance at the animal region, we refer to the dnd, nos1, and vas RNAs as the early animal germ plasm RNAs, while dazl is also referred to as a vegetally localized germ plasm RNA. " RLID00018102 6066 RNU2-1 http://www.ncbi.nlm.nih.gov/gene/?term=6066 "RNU2, U2 " snRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00018103 6066 RNU2-1 http://www.ncbi.nlm.nih.gov/gene/?term=6066 "RNU2, U2 " snRNA Homo sapiens 1530887 Nucleus HeLa cell In situ hybridization "The localization of U1 and U2 small nuclear RNAs (snRNAs) has been examined by in situ hybridization using 2'-O-alkyl oligonucleotide probes. We have found that these snRNAs, which are essential for pre-mRNA splicing, localize in a speckled distribution, in addition to being present in three of four foci, in HeLa cell nuclei. However, in cells of defined passage, such as Detroit 551 and WI-38 fibroblasts, these snRNAs are concentrated in nuclear speckles, and foci are not observed. " RLID00018104 6066 RNU2-1 http://www.ncbi.nlm.nih.gov/gene/?term=6066 "RNU2, U2 " snRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018105 6066 RNU2-1 http://www.ncbi.nlm.nih.gov/gene/?term=6066 "RNU2, U2 " snRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018106 60673 ATG101 http://www.ncbi.nlm.nih.gov/gene/?term=60673 C12orf44 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018107 60673 ATG101 http://www.ncbi.nlm.nih.gov/gene/?term=60673 C12orf44 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018108 60674 GAS5 http://www.ncbi.nlm.nih.gov/gene/?term=60674 "NCRNA00030, SNHG2 " lncRNA Homo sapiens 20124551 Nucleus HeLa cell Fluorescence in situ hybridization "We examined the subcellular localization of Gas5 in HeLa cells with RNA fluorescent in situ hybridization. Gas5 was localized both in the cytoplasm and the nucleus, but its presence was more prominent in the former compartment in agreement with a previous report (Fig. 3A, top panels). " RLID00018109 60674 GAS5 http://www.ncbi.nlm.nih.gov/gene/?term=60674 "NCRNA00030, SNHG2 " lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018110 60674 GAS5 http://www.ncbi.nlm.nih.gov/gene/?term=60674 "NCRNA00030, SNHG2 " lncRNA Homo sapiens 20124551 Cytoplasm HeLa cell Fluorescence in situ hybridization "We examined the subcellular localization of Gas5 in HeLa cells with RNA fluorescent in situ hybridization. Gas5 was localized both in the cytoplasm and the nucleus, but its presence was more prominent in the former compartment in agreement with a previous report (Fig. 3A, top panels). " RLID00018111 60674 GAS5 http://www.ncbi.nlm.nih.gov/gene/?term=60674 "NCRNA00030, SNHG2 " lncRNA Homo sapiens 26446789 Cytoplasm Hepatic stellate cell qRT-PCR "In addition, GAS5 was mainly localized in the cytoplasm. " RLID00018112 60674 GAS5 http://www.ncbi.nlm.nih.gov/gene/?term=60674 "NCRNA00030, SNHG2 " lncRNA Homo sapiens 22955988 Nucleus Brain Microarray "We examined the subcellular location of a number of well-known lncRNAs (Fig. 8D). Unsurprisingly, the X-chromosome inactivating transcript XIST was extremely highly enriched in the nucleus for all cells we examined (with a maximum enrichment of 273-fold in the nucleus of GM12878 cells) (Fig. 8D). Other regulatory lncRNAs such as GAS5, LINC00568 (also known as ncRNA-a1), CYP4A22-AS1 (also known as ncRNA-a3), MIAT, and MEG3 were nuclear enriched in at least two different cell types, consistent with their reported roles in gene regulation. Other transcripts, including the bifunctional transcript SRA1, which acts as both a regulatory RNA and a protein-coding sequence, have more variable subcellular location depending on cell type. As reported previously, the H19 transcript is consistently enriched in the cytoplasm, especially when comparing with the chromatin fraction (cytoplasmic/chromatin enrichment 167-fold). " RLID00018113 60674 GAS5 http://www.ncbi.nlm.nih.gov/gene/?term=60674 "NCRNA00030, SNHG2 " mRNA Homo sapiens 25630241 Cytoplasm Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00018114 60674 GAS5 http://www.ncbi.nlm.nih.gov/gene/?term=60674 "NCRNA00030, SNHG2 " mRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00018115 60674 GAS5 http://www.ncbi.nlm.nih.gov/gene/?term=60674 "NCRNA00030, SNHG2 " lncRNA Homo sapiens 25630241 Nucleus Hela cell qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00018116 60674 GAS5 http://www.ncbi.nlm.nih.gov/gene/?term=60674 "NCRNA00030, SNHG2 " lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00018117 60676 PAPPA2 http://www.ncbi.nlm.nih.gov/gene/?term=60676 "PAPP-A2, PAPP-E, PAPPE, PLAC3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018118 60678 EEFSEC http://www.ncbi.nlm.nih.gov/gene/?term=60678 "EFSEC, SELB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018119 60681 FKBP10 http://www.ncbi.nlm.nih.gov/gene/?term=60681 "BRKS1, FKBP65, OI11, OI6, PPIASE, hFKBP65 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018120 60681 FKBP10 http://www.ncbi.nlm.nih.gov/gene/?term=60681 "BRKS1, FKBP65, OI11, OI6, PPIASE, hFKBP65 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018121 60684 TRAPPC11 http://www.ncbi.nlm.nih.gov/gene/?term=60684 "C4orf41, FOIGR, GRY, LGMD2S " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018122 60685 ZFAND3 http://www.ncbi.nlm.nih.gov/gene/?term=60685 TEX27 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018123 6069 RNU4-7P http://www.ncbi.nlm.nih.gov/gene/?term=6069 "RNU4P1, U4, U4/7 " snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018124 607000 MED31 http://www.ncbi.nlm.nih.gov/gene/?term=607000 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018125 607044 RNF41 http://www.ncbi.nlm.nih.gov/gene/?term=607044 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018126 6071 RNU6V http://www.ncbi.nlm.nih.gov/gene/?term=6071 "87U6, LH87 " snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018127 607260 PFDN5 http://www.ncbi.nlm.nih.gov/gene/?term=607260 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018128 607367 RFXAP http://www.ncbi.nlm.nih.gov/gene/?term=607367 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018129 607383 RASSF4 http://www.ncbi.nlm.nih.gov/gene/?term=607383 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018130 607430 PPIL3 http://www.ncbi.nlm.nih.gov/gene/?term=607430 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018131 607633 RPL21 http://www.ncbi.nlm.nih.gov/gene/?term=607633 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018132 607652 WDR37 http://www.ncbi.nlm.nih.gov/gene/?term=607652 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018133 607878 PIN4 http://www.ncbi.nlm.nih.gov/gene/?term=607878 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018134 6079 SNORD15A http://www.ncbi.nlm.nih.gov/gene/?term=6079 "RNU15A, SNORNA, U15A " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00018135 6079 SNORD15A http://www.ncbi.nlm.nih.gov/gene/?term=6079 "RNU15A, SNORNA, U15A " snoRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 6. Ten Most Highly Expressed snoRNAs of Exosome I, Exosome II and W. Data are collected from Table 6. " RLID00018136 6079 SNORD15A http://www.ncbi.nlm.nih.gov/gene/?term=6079 "RNU15A, SNORNA, U15A " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018137 6079 SNORD15A http://www.ncbi.nlm.nih.gov/gene/?term=6079 "RNU15A, SNORNA, U15A " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018138 6080 SNORA73A http://www.ncbi.nlm.nih.gov/gene/?term=6080 "E1, E1-7, E1b, RNE1, RNU17A, U17A " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018139 6080 SNORA73A http://www.ncbi.nlm.nih.gov/gene/?term=6080 "E1, E1-7, E1b, RNE1, RNU17A, U17A " snoRNA Homo sapiens 9671460 Nucleus HeLa cell Northern blot "We investigated the cellular localization of the U17HG RNA. Cell fractionation experiments indicated that U17HG RNA is enriched in the cytoplasm (Fig.5A), similar to UHG RNA, another noncoding snoRNA host having no protein-coding potential (Fig.5B). As expected, U17 snoRNA, used as a control, was found mainly in the nuclear fraction (Fig.5C). " RLID00018140 6080 SNORA73A http://www.ncbi.nlm.nih.gov/gene/?term=6080 "E1, E1-7, E1b, RNE1, RNU17A, U17A " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00018141 6080 SNORA73A http://www.ncbi.nlm.nih.gov/gene/?term=6080 "E1, E1-7, E1b, RNE1, RNU17A, U17A " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00018142 6082 SNORD20 http://www.ncbi.nlm.nih.gov/gene/?term=6082 "RNU20, U20 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018143 6082 SNORD20 http://www.ncbi.nlm.nih.gov/gene/?term=6082 "RNU20, U20 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00018144 6082 SNORD20 http://www.ncbi.nlm.nih.gov/gene/?term=6082 "RNU20, U20 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018145 6082 SNORD20 http://www.ncbi.nlm.nih.gov/gene/?term=6082 "RNU20, U20 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018146 6083 SNORD21 http://www.ncbi.nlm.nih.gov/gene/?term=6083 "RNU21, U21 " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00018147 6083 SNORD21 http://www.ncbi.nlm.nih.gov/gene/?term=6083 "RNU21, U21 " snoRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 6. Ten Most Highly Expressed snoRNAs of Exosome I, Exosome II and W. Data are collected from Table 6. " RLID00018148 6083 SNORD21 http://www.ncbi.nlm.nih.gov/gene/?term=6083 "RNU21, U21 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018149 6083 SNORD21 http://www.ncbi.nlm.nih.gov/gene/?term=6083 "RNU21, U21 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018150 608666 SNX24 http://www.ncbi.nlm.nih.gov/gene/?term=608666 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018151 608922 PPP6C http://www.ncbi.nlm.nih.gov/gene/?term=608922 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018152 609036 DSCC1 http://www.ncbi.nlm.nih.gov/gene/?term=609036 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018153 609164 GTF2F2 http://www.ncbi.nlm.nih.gov/gene/?term=609164 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018154 6091 ROBO1 http://www.ncbi.nlm.nih.gov/gene/?term=6091 "DUTT1, SAX3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018155 6091 ROBO1 http://www.ncbi.nlm.nih.gov/gene/?term=6091 "DUTT1, SAX3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018156 6092 ROBO2 http://www.ncbi.nlm.nih.gov/gene/?term=6092 SAX3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018157 609356 MPC1 http://www.ncbi.nlm.nih.gov/gene/?term=609356 BRP44L mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018158 6093 ROCK1 http://www.ncbi.nlm.nih.gov/gene/?term=6093 "P160ROCK, ROCK-I " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018159 6093 ROCK1 http://www.ncbi.nlm.nih.gov/gene/?term=6093 "P160ROCK, ROCK-I " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018160 6094 ROM1 http://www.ncbi.nlm.nih.gov/gene/?term=6094 "ROM, ROSP1, RP7, TSPAN23 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018161 609530 RPL31 http://www.ncbi.nlm.nih.gov/gene/?term=609530 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018162 609743 WWTR1 http://www.ncbi.nlm.nih.gov/gene/?term=609743 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018163 609840 AP1M1 http://www.ncbi.nlm.nih.gov/gene/?term=609840 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018164 6098 ROS1 http://www.ncbi.nlm.nih.gov/gene/?term=6098 "MCF3, ROS, c-ros-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018165 609906 MRPS16 http://www.ncbi.nlm.nih.gov/gene/?term=609906 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018166 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018167 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 22895844 Exosome Colon|Liver|Lung qRT-PCR "When the RNA species within exosomes derived from the three CRC cell lines were examined, the mRNAs of housekeeping genes such as ACTB and GAPDH, the microRNAs such as miR-21, miR-192 and miR-221, and the natural antisense RNAs of LRRC24, MDM2 and CDKN1A genes, were detected. " RLID00018168 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 12923260 Cell leading edge Jurkat cell In situ hybridization "As well, beta-actin mRNA is known to undergo cytoskeleton-dependent transport to the leading edge of cells and, as demonstrated by in situ hybridization studies, displays both a leading edge and a distinct, perinuclear localization, similar to that depicted in Figures 6 and 7. " RLID00018169 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 15081402 Nucleus HeLa cell In situ hybridization "Distributions of mature mRNA and pre-mRNA for b-actin transcripts were determined by RT-PCR using total RNA from each subnuclear fraction. PCR products in panels 1-3 indicate a band derived from mature mRNA of β-actin, and those in lanes 4-6 are from pre-mRNA. " RLID00018170 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 18535985 Cell leading edge SW480 CRC cell Fluorescence in situ hybridization|qRT-PCR "In culture, VICKZ proteins rapidly accumulate in processes at the leading edge of PMA-stimulated SW480 CRC cells, where they co-localize with beta-actin mRNA. " RLID00018171 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 20453113 Cytosol NCI/ADR-RES cell qRT-PCR "The relative partitioning of both cytosolic (ACTB, H3.3) and ER-bound (MDR1, CANX) transcripts between both fractions was marked, despite the small carryover of cytosol in the ER fraction (Fig. 2B). Polysome profile analyses from the isolated fractions indicated that these transcripts migrated in polyribosome-containing fractions (Fig. 2C). Notably, the distribution of ER-bound transcripts between the ER and cytosol did not change on arsenite treatment of NCI/ADR-RES cells (Fig. 2D). Data are collected from Figure 2. " RLID00018172 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 23452202 Lamellipodium Lung fibroblast Fluorescence in situ hybridization "Rac1, ArpC2 and β-actin mRNAs co-localize with actively translating ribosomes on lamellipodia. " RLID00018173 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 23452202 Cell leading edge Lung fibroblast qRT-PCR "In the present study with MRC5 cells, we show that β-actin mRNA is similarly localized to active foci on the leading edge of the cell and is furthermore recruited to polysomes. " RLID00018174 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 26195734 Mitochondrion HeLa cell Sticky-Flare Synthesis "In this case, β-actin Sticky-flares exhibited a starkly different intracellular distribution, showing a high degree of colocalization with mitochondria (Fig. 5). This colocalization of β-actin mRNA and mitochondria in HeLa cells has not been demonstrated before, and the reason behind such highly spatially restricted expression is not known. " RLID00018175 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 26239904 Ribosome Kidney RT-PCR "Although the underlying mechanisms were not known, this increased association might be attributed to the diffused localization of the 32-447aa mutant, thereby allowing the mutant to associate not only with ATF4 mRNAs on the ER but also with the mRNAs in cytoplasm. (D-F) The abundance of ATF4 or β-actin mRNA in the subpolysome or polysome pool. " RLID00018176 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018177 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018178 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018179 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 22193719 Cytoplasm Embryonic stem cell qRT-PCR|Microarray "Figure 7: Neuronal lncRNAs act via diverse mechanisms. (A) Quantification of relative expression of lncRNAs in nuclear and cytoplasmic cell fractions. (B) Quantification of changes in hosted miRNAs in response to lncRNA_N2 knockdown. MiRNAs were quantified using Taqman miRNA qPCR. (C-E) RIP of lncRNAs with SUZ12 and REST antibodies. The interaction of HOTAIR with SUZ12 is a known interaction that serves as a positive control (Gupta et al, 2010). * and ** indicate P-values of <0.05 and <0.01, respectively. Data are collected from Figure 7. " RLID00018180 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 22679391 Cytoplasm U2OS cell RT-PCR "Figure 3A: The levels of Sec61α and βactin transcripts isolated from unbound (i.e., non-ER) cytoplasmic and ER fractions from either cycloheximide treated (“Control� or puromycin treated EDTA extracted (“Puromycin+EDTA� U2OS cells were assessed by quantitative RT-PCR analysis. " RLID00018181 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 25753659 Cytosol HT1080 cell Fluorescence in situ hybridization|qRT-PCR "Figure S2: Expression of mRNA candidates in ribosomes-containing sub-compartments. A: Representative Western blot analyses of markers in the sub-compartments. S10 supernatants as used in Figure 1 for polysomal gradient analysis represent a cytoplasmic fraction as demonstrated by cytosolic markers (GAPDH, beta-Actin). Both, cytoplasmic and sediment fractions contain polysomes as shown by ribosomal markers (28S and 18S rRNA, ribosomal protein RPL7A). Sediments, however, contain ER as indicated by the presence of the ER marker proteins (PDI and aromatase). " RLID00018182 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 25753659 Ribosome HT1080 cell qRT-PCR Figure S1: Polysomal gradient analysis. HT1080 cells were incubated under control (21% oxygen) or hypoxic (1% oxygen) conditions for up to 36 h as described in Figure 1. Shown are representative original RT-PCR data (30 cycles for beta-Actin and the external standard [extSt]; 35 cycles for the other genes) from pooled samples to visualize mRNA distribution following fractionation of sucrose gradients at control conditions (C) and 36 h of hypoxia (Hy). The external standard (a synthetic in vitro transcript) was diluted to appropriate concentration for qPCR and added directly after gradient fractionation and prior to RNA isolation as a technical control. The external standard served for fraction dependent normalization. RLID00018183 60 ACTB http://www.ncbi.nlm.nih.gov/gene/?term=60 "BRWS1, PS1TP5BP1 " mRNA Homo sapiens 23452202 Ribosome Lung fibroblast qRT-PCR "In the present study with MRC5 cells, we show that β-actin mRNA is similarly localized to active foci on the leading edge of the cell and is furthermore recruited to polysomes. " RLID00018184 6100 RP9 http://www.ncbi.nlm.nih.gov/gene/?term=6100 "PAP-1, PAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018185 610267 ALDH16A1 http://www.ncbi.nlm.nih.gov/gene/?term=610267 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018186 6102 RP2 http://www.ncbi.nlm.nih.gov/gene/?term=6102 "DELXp11.3, NM23-H10, NME10, TBCCD2, XRP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018187 6102 RP2 http://www.ncbi.nlm.nih.gov/gene/?term=6102 "DELXp11.3, NM23-H10, NME10, TBCCD2, XRP2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018188 610533 DPH3 http://www.ncbi.nlm.nih.gov/gene/?term=610533 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018189 610538 DEK http://www.ncbi.nlm.nih.gov/gene/?term=610538 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018190 610596 RPS29 http://www.ncbi.nlm.nih.gov/gene/?term=610596 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018191 610883 ACOT13 http://www.ncbi.nlm.nih.gov/gene/?term=610883 THEM2 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018192 610925 PKIG http://www.ncbi.nlm.nih.gov/gene/?term=610925 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018193 610942 CYB5B http://www.ncbi.nlm.nih.gov/gene/?term=610942 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018194 611248 ARL2BP http://www.ncbi.nlm.nih.gov/gene/?term=611248 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018195 611783 EFCAB2 http://www.ncbi.nlm.nih.gov/gene/?term=611783 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018196 6118 RPA2 http://www.ncbi.nlm.nih.gov/gene/?term=6118 "REPA2, RP-A p32, RP-A p34, RPA32 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018197 6118 RPA2 http://www.ncbi.nlm.nih.gov/gene/?term=6118 "REPA2, RP-A p32, RP-A p34, RPA32 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018198 611923 SRP9 http://www.ncbi.nlm.nih.gov/gene/?term=611923 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018199 6119 RPA3 http://www.ncbi.nlm.nih.gov/gene/?term=6119 "REPA3, RP-A p14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018200 6119 RPA3 http://www.ncbi.nlm.nih.gov/gene/?term=6119 "REPA3, RP-A p14 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018201 6119 RPA3 http://www.ncbi.nlm.nih.gov/gene/?term=6119 "REPA3, RP-A p14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018202 6120 RPE http://www.ncbi.nlm.nih.gov/gene/?term=6120 RPE2-1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018203 6120 RPE http://www.ncbi.nlm.nih.gov/gene/?term=6120 RPE2-1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018204 612309 ABLIM3 http://www.ncbi.nlm.nih.gov/gene/?term=612309 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018205 612448 RPS6KA2 http://www.ncbi.nlm.nih.gov/gene/?term=612448 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018206 6124 RPL4 http://www.ncbi.nlm.nih.gov/gene/?term=6124 L4 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018207 6125 RPL5 http://www.ncbi.nlm.nih.gov/gene/?term=6125 "DBA6, L5, MSTP030, PPP1R135 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018208 6125 RPL5 http://www.ncbi.nlm.nih.gov/gene/?term=6125 "DBA6, L5, MSTP030, PPP1R135 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018209 6125 RPL5 http://www.ncbi.nlm.nih.gov/gene/?term=6125 "DBA6, L5, MSTP030, PPP1R135 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018210 612796 ARL6 http://www.ncbi.nlm.nih.gov/gene/?term=612796 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018211 6128 RPL6 http://www.ncbi.nlm.nih.gov/gene/?term=6128 "L6, SHUJUN-2, TAXREB107, TXREB1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018212 6128 RPL6 http://www.ncbi.nlm.nih.gov/gene/?term=6128 "L6, SHUJUN-2, TAXREB107, TXREB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018213 612924 MOB1A http://www.ncbi.nlm.nih.gov/gene/?term=612924 "MOBK1B, MOBKL1B " mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018214 612942 LOC612942 http://www.ncbi.nlm.nih.gov/gene/?term=612942 "MSANTD3, TMEFF1 " mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018215 612965 FKBP1B http://www.ncbi.nlm.nih.gov/gene/?term=612965 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00018216 6129 RPL7 http://www.ncbi.nlm.nih.gov/gene/?term=6129 "L7, humL7-1 " mRNA Homo sapiens 12399102 Cell body Purkinje cell In situ hybridization In addition we performed in situ hybridization on a developmental series of human cerebellar sections and demonstrate that the L7/Pcp-2 mRNA is also localized in dendrites of humans. RLID00018217 6129 RPL7 http://www.ncbi.nlm.nih.gov/gene/?term=6129 "L7, humL7-1 " mRNA Homo sapiens 12399102 Dendrite Purkinje cell In situ hybridization In addition we performed in situ hybridization on a developmental series of human cerebellar sections and demonstrate that the L7/Pcp-2 mRNA is also localized in dendrites of humans. RLID00018218 613037 LOC613037 http://www.ncbi.nlm.nih.gov/gene/?term=613037 lncRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00018219 6130 RPL7A http://www.ncbi.nlm.nih.gov/gene/?term=6130 "L7A, SURF3, TRUP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018220 613117 4930571B16Rik http://www.ncbi.nlm.nih.gov/gene/?term=613117 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00018221 6132 RPL8 http://www.ncbi.nlm.nih.gov/gene/?term=6132 L8 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018222 6133 RPL9 http://www.ncbi.nlm.nih.gov/gene/?term=6133 "L9, NPC-A-16 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018223 6133 RPL9 http://www.ncbi.nlm.nih.gov/gene/?term=6133 "L9, NPC-A-16 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018224 6133 RPL9 http://www.ncbi.nlm.nih.gov/gene/?term=6133 "L9, NPC-A-16 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018225 6134 RPL10 http://www.ncbi.nlm.nih.gov/gene/?term=6134 "AUTSX5, DXS648, DXS648E, L10, NOV, QM " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018226 6134 RPL10 http://www.ncbi.nlm.nih.gov/gene/?term=6134 "AUTSX5, DXS648, DXS648E, L10, NOV, QM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018227 6135 RPL11 http://www.ncbi.nlm.nih.gov/gene/?term=6135 "DBA7, GIG34, L11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018228 6136 RPL12 http://www.ncbi.nlm.nih.gov/gene/?term=6136 L12 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018229 6136 RPL12 http://www.ncbi.nlm.nih.gov/gene/?term=6136 L12 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018230 6137 RPL13 http://www.ncbi.nlm.nih.gov/gene/?term=6137 "BBC1, D16S444E, D16S44E, L13 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018231 6137 RPL13 http://www.ncbi.nlm.nih.gov/gene/?term=6137 "BBC1, D16S444E, D16S44E, L13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018232 6138 RPL15 http://www.ncbi.nlm.nih.gov/gene/?term=6138 "DBA12, EC45, L15, RPL10, RPLY10, RPYL10 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018233 6138 RPL15 http://www.ncbi.nlm.nih.gov/gene/?term=6138 "DBA12, EC45, L15, RPL10, RPLY10, RPYL10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018234 6139 RPL17 http://www.ncbi.nlm.nih.gov/gene/?term=6139 "L17, PD-1, RPL23 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018235 6139 RPL17 http://www.ncbi.nlm.nih.gov/gene/?term=6139 "L17, PD-1, RPL23 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018236 6139 RPL17 http://www.ncbi.nlm.nih.gov/gene/?term=6139 "L17, PD-1, RPL23 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018237 613 BCR http://www.ncbi.nlm.nih.gov/gene/?term=613 "ALL1, CML, D22S11, D22S662, PHL, BCR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018238 613 BCR http://www.ncbi.nlm.nih.gov/gene/?term=613 "ALL, BCR1, CML, D22S11, D22S662, PHL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018239 6141 RPL18 http://www.ncbi.nlm.nih.gov/gene/?term=6141 L18 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018240 6141 RPL18 http://www.ncbi.nlm.nih.gov/gene/?term=6141 L18 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018241 6142 RPL18A http://www.ncbi.nlm.nih.gov/gene/?term=6142 L18A mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018242 6142 RPL18A http://www.ncbi.nlm.nih.gov/gene/?term=6142 L18A mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018243 6144 RPL21 http://www.ncbi.nlm.nih.gov/gene/?term=6144 "HYPT12, L21 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018244 6144 RPL21 http://www.ncbi.nlm.nih.gov/gene/?term=6144 "HYPT12, L21 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018245 6146 RPL22 http://www.ncbi.nlm.nih.gov/gene/?term=6146 "EAP, HBP15, HBP15/L22, L22 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018246 6147 RPL23A http://www.ncbi.nlm.nih.gov/gene/?term=6147 "L23A, MDA20 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018247 6150 MRPL23 http://www.ncbi.nlm.nih.gov/gene/?term=6150 "L23MRP, RPL23, RPL23L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018248 6152 RPL24 http://www.ncbi.nlm.nih.gov/gene/?term=6152 "HEL-S-310, L24 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018249 6154 RPL26 http://www.ncbi.nlm.nih.gov/gene/?term=6154 "DBA11, L26 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018250 6154 RPL26 http://www.ncbi.nlm.nih.gov/gene/?term=6154 "DBA11, L26 " mRNA Homo sapiens 18192611 Ribosome HeLa cell Northern blot FIGURE 2. Subcellular mRNA distribution in SRP54 knock-down HeLa cell lines. (A) Total RNA from control HeLa (H) or SRP54 (54) stable knock-down cells was analyzed by Northern blot. (B) Cell surface expression of DR4 was determined by flow cytometry using no primary antibody (control) or DR4 antibody. (C) Cells were fractionated by sequential detergent extraction into cytosol (lane C) or membrane-bound (lane M) fractions. RNA isolated from total cells (lane T) or cell fractions was analyzed by Northern blot using the probes listed in Materials and Methods. Data are collected from Figure 2. RLID00018251 6155 RPL27 http://www.ncbi.nlm.nih.gov/gene/?term=6155 L27 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018252 6156 RPL30 http://www.ncbi.nlm.nih.gov/gene/?term=6156 L30 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018253 6156 RPL30 http://www.ncbi.nlm.nih.gov/gene/?term=6156 L30 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018254 6156 RPL30 http://www.ncbi.nlm.nih.gov/gene/?term=6156 L30 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018255 6157 RPL27A http://www.ncbi.nlm.nih.gov/gene/?term=6157 L27A mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018256 6157 RPL27A http://www.ncbi.nlm.nih.gov/gene/?term=6157 L27A mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018257 6157 RPL27A http://www.ncbi.nlm.nih.gov/gene/?term=6157 L27A mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018258 6157 RPL27A http://www.ncbi.nlm.nih.gov/gene/?term=6157 L27A mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018259 6158 RPL28 http://www.ncbi.nlm.nih.gov/gene/?term=6158 L28 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018260 6158 RPL28 http://www.ncbi.nlm.nih.gov/gene/?term=6158 L28 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018261 6159 RPL29 http://www.ncbi.nlm.nih.gov/gene/?term=6159 "HIP, HUMRPL29, L29P10, RPL29_3_370, RPL29 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018262 6159 RPL29 http://www.ncbi.nlm.nih.gov/gene/?term=6159 "HIP, HUMRPL29, L29, RPL29P10, RPL29_3_370 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018263 6160 RPL31 http://www.ncbi.nlm.nih.gov/gene/?term=6160 L31 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018264 6160 RPL31 http://www.ncbi.nlm.nih.gov/gene/?term=6160 L31 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018265 6161 RPL32 http://www.ncbi.nlm.nih.gov/gene/?term=6161 "L32, PP9932 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018266 6165 RPL35A http://www.ncbi.nlm.nih.gov/gene/?term=6165 "DBA5, L35A " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018267 6165 RPL35A http://www.ncbi.nlm.nih.gov/gene/?term=6165 "DBA5, L35A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018268 6166 RPL36AL http://www.ncbi.nlm.nih.gov/gene/?term=6166 RPL36A mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018269 6166 RPL36AL http://www.ncbi.nlm.nih.gov/gene/?term=6166 RPL36A mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018270 6166 RPL36AL http://www.ncbi.nlm.nih.gov/gene/?term=6166 RPL36A mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018271 6167 RPL37 http://www.ncbi.nlm.nih.gov/gene/?term=6167 L37 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018272 6167 RPL37 http://www.ncbi.nlm.nih.gov/gene/?term=6167 L37 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018273 6168 RPL37A http://www.ncbi.nlm.nih.gov/gene/?term=6168 L37A mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018274 6169 RPL38 http://www.ncbi.nlm.nih.gov/gene/?term=6169 L38 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018275 6170 RPL39 http://www.ncbi.nlm.nih.gov/gene/?term=6170 "L39P42, RPL39_23_1806, RPL39 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018276 6170 RPL39 http://www.ncbi.nlm.nih.gov/gene/?term=6170 "L39P42, RPL39_23_1806, RPL39 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018277 6170 RPL39 http://www.ncbi.nlm.nih.gov/gene/?term=6170 "L39P42, RPL39_23_1806, RPL39 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018278 6170 RPL39 http://www.ncbi.nlm.nih.gov/gene/?term=6170 "L39, RPL39P42, RPL39_23_1806 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018279 6171 RPL41 http://www.ncbi.nlm.nih.gov/gene/?term=6171 L41 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018280 6175 RPLP0 http://www.ncbi.nlm.nih.gov/gene/?term=6175 "L10E, LP0, P0, PRLP0, RPP0 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018281 6176 RPLP1 http://www.ncbi.nlm.nih.gov/gene/?term=6176 "LP1, P1, RPP1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018282 6181 RPLP2 http://www.ncbi.nlm.nih.gov/gene/?term=6181 "D11S2243E, LP2, P2, RPP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018283 6182 MRPL12 http://www.ncbi.nlm.nih.gov/gene/?term=6182 "5c5-2, L12mt, MRP-L31/34, MRPL7, MRPL7/L12, RPML12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018284 6183 MRPS12 http://www.ncbi.nlm.nih.gov/gene/?term=6183 "MPR-S12, MT-RPS12, RPMS12, RPS12, RPSM12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018285 6183 MRPS12 http://www.ncbi.nlm.nih.gov/gene/?term=6183 "MPR-S12, MT-RPS12, RPMS12, RPS12, RPSM12 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018286 6184 RPN1 http://www.ncbi.nlm.nih.gov/gene/?term=6184 "OST1, RBPH1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018287 6184 RPN1 http://www.ncbi.nlm.nih.gov/gene/?term=6184 "OST1, RBPH1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018288 6184 RPN1 http://www.ncbi.nlm.nih.gov/gene/?term=6184 "OST1, RBPH1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018289 6185 RPN2 http://www.ncbi.nlm.nih.gov/gene/?term=6185 "RIBIIR, RPN-II, RPNII, SWP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018290 6187 RPS2 http://www.ncbi.nlm.nih.gov/gene/?term=6187 "LLREP3, S2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018291 6187 RPS2 http://www.ncbi.nlm.nih.gov/gene/?term=6187 "LLREP3, S2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018292 6187 RPS2 http://www.ncbi.nlm.nih.gov/gene/?term=6187 "LLREP3, S2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018293 6188 RPS3 http://www.ncbi.nlm.nih.gov/gene/?term=6188 S3 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018294 6188 RPS3 http://www.ncbi.nlm.nih.gov/gene/?term=6188 S3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018295 6188 RPS3 http://www.ncbi.nlm.nih.gov/gene/?term=6188 S3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018296 6189 RPS3A http://www.ncbi.nlm.nih.gov/gene/?term=6189 "FTE1, MFTL, S3A " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018297 6189 RPS3A http://www.ncbi.nlm.nih.gov/gene/?term=6189 "FTE1, MFTL, S3A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018298 6189 RPS3A http://www.ncbi.nlm.nih.gov/gene/?term=6189 "FTE1, MFTL, S3A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018299 6191 RPS4X http://www.ncbi.nlm.nih.gov/gene/?term=6191 "CCG2, DXS306, RPS4, S4, SCAR, SCR10 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018300 6191 RPS4X http://www.ncbi.nlm.nih.gov/gene/?term=6191 "CCG2, DXS306, RPS4, S4, SCAR, SCR10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018301 619207 SCART1 http://www.ncbi.nlm.nih.gov/gene/?term=619207 lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00018302 619208 FAM229B http://www.ncbi.nlm.nih.gov/gene/?term=619208 C6orf225 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018303 619292 G430095P16Rik http://www.ncbi.nlm.nih.gov/gene/?term=619292 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018304 619295 Lrp8os2 http://www.ncbi.nlm.nih.gov/gene/?term=619295 B230314M03Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018305 6192 RPS4Y1 http://www.ncbi.nlm.nih.gov/gene/?term=6192 "RPS4Y, S4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018306 619383 SCARNA9 http://www.ncbi.nlm.nih.gov/gene/?term=619383 "Z32, mgU2-19/30 " lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018307 619383 SCARNA9 http://www.ncbi.nlm.nih.gov/gene/?term=619383 "Z32, mgU2-19/30 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018308 6193 RPS5 http://www.ncbi.nlm.nih.gov/gene/?term=6193 S5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018309 6193 RPS5 http://www.ncbi.nlm.nih.gov/gene/?term=6193 S5 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018310 619498 SNORD74 http://www.ncbi.nlm.nih.gov/gene/?term=619498 "SNORD74A, U74, Z18 " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00018311 619498 SNORD74 http://www.ncbi.nlm.nih.gov/gene/?term=619498 "SNORD74A, U74, Z18 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00018312 619498 SNORD74 http://www.ncbi.nlm.nih.gov/gene/?term=619498 "SNORD74A, U74, Z18 " snoRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 6. Ten Most Highly Expressed snoRNAs of Exosome I, Exosome II and W. Data are collected from Table 6. " RLID00018313 619498 SNORD74 http://www.ncbi.nlm.nih.gov/gene/?term=619498 "SNORD74A, U74, Z18 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018314 619498 SNORD74 http://www.ncbi.nlm.nih.gov/gene/?term=619498 "SNORD74A, U74, Z18 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018315 6194 RPS6 http://www.ncbi.nlm.nih.gov/gene/?term=6194 S6 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018316 619562 SNORA3A http://www.ncbi.nlm.nih.gov/gene/?term=619562 "ACA3, SNORA3, SNORA45A " snoRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00018317 619564 SNORD72 http://www.ncbi.nlm.nih.gov/gene/?term=619564 HBII-240 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018318 619564 SNORD72 http://www.ncbi.nlm.nih.gov/gene/?term=619564 HBII-240 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00018319 619565 SNORA52 http://www.ncbi.nlm.nih.gov/gene/?term=619565 ACA52 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00018320 619567 SNORD2 http://www.ncbi.nlm.nih.gov/gene/?term=619567 "R39B, SNR39B " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00018321 619567 SNORD2 http://www.ncbi.nlm.nih.gov/gene/?term=619567 "R39B, SNR39B " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00018322 619567 SNORD2 http://www.ncbi.nlm.nih.gov/gene/?term=619567 "R39B, SNR39B " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00018323 619567 SNORD2 http://www.ncbi.nlm.nih.gov/gene/?term=619567 "R39B, SNR39B " snoRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 6. Ten Most Highly Expressed snoRNAs of Exosome I, Exosome II and W. Data are collected from Table 6. " RLID00018324 619567 SNORD2 http://www.ncbi.nlm.nih.gov/gene/?term=619567 "R39B, SNR39B " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018325 619567 SNORD2 http://www.ncbi.nlm.nih.gov/gene/?term=619567 "R39B, SNR39B " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018326 619570 SNORD95 http://www.ncbi.nlm.nih.gov/gene/?term=619570 U95 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00018327 619570 SNORD95 http://www.ncbi.nlm.nih.gov/gene/?term=619570 U95 snoRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00018328 619571 SNORD96A http://www.ncbi.nlm.nih.gov/gene/?term=619571 U96A snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00018329 619571 SNORD96A http://www.ncbi.nlm.nih.gov/gene/?term=619571 U96A snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00018330 6195 RPS6KA1 http://www.ncbi.nlm.nih.gov/gene/?term=6195 "HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018331 6195 RPS6KA1 http://www.ncbi.nlm.nih.gov/gene/?term=6195 "HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018332 6196 RPS6KA2 http://www.ncbi.nlm.nih.gov/gene/?term=6196 "HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, p90RSK2, pp90RSK3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018333 619719 6430590A07Rik http://www.ncbi.nlm.nih.gov/gene/?term=619719 EG619719 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00018334 6197 RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/?term=6197 "CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018335 6197 RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/?term=6197 "CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018336 6197 RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/?term=6197 "CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018337 6198 RPS6KB1 http://www.ncbi.nlm.nih.gov/gene/?term=6198 "PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018338 6198 RPS6KB1 http://www.ncbi.nlm.nih.gov/gene/?term=6198 "PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018339 6198 RPS6KB1 http://www.ncbi.nlm.nih.gov/gene/?term=6198 "PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018340 6199 RPS6KB2 http://www.ncbi.nlm.nih.gov/gene/?term=6199 "KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018341 6199 RPS6KB2 http://www.ncbi.nlm.nih.gov/gene/?term=6199 "KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018342 6201 RPS7 http://www.ncbi.nlm.nih.gov/gene/?term=6201 "DBA8, S7 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018343 6201 RPS7 http://www.ncbi.nlm.nih.gov/gene/?term=6201 "DBA8, S7 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018344 6202 RPS8 http://www.ncbi.nlm.nih.gov/gene/?term=6202 S8 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018345 6203 RPS9 http://www.ncbi.nlm.nih.gov/gene/?term=6203 S9 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018346 6203 RPS9 http://www.ncbi.nlm.nih.gov/gene/?term=6203 S9 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018347 6204 RPS10 http://www.ncbi.nlm.nih.gov/gene/?term=6204 "DBA9, S10 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018348 6206 RPS12 http://www.ncbi.nlm.nih.gov/gene/?term=6206 S12 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018349 6206 RPS12 http://www.ncbi.nlm.nih.gov/gene/?term=6206 S12 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018350 6206 RPS12 http://www.ncbi.nlm.nih.gov/gene/?term=6206 S12 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018351 6207 RPS13 http://www.ncbi.nlm.nih.gov/gene/?term=6207 S13 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018352 6207 RPS13 http://www.ncbi.nlm.nih.gov/gene/?term=6207 S13 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018353 6208 RPS14 http://www.ncbi.nlm.nih.gov/gene/?term=6208 "EMTB, S14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018354 6208 RPS14 http://www.ncbi.nlm.nih.gov/gene/?term=6208 "EMTB, S14 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018355 6208 RPS14 http://www.ncbi.nlm.nih.gov/gene/?term=6208 "EMTB, S14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018356 6209 RPS15 http://www.ncbi.nlm.nih.gov/gene/?term=6209 "RIG, S15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018357 6210 RPS15A http://www.ncbi.nlm.nih.gov/gene/?term=6210 S15a mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018358 6210 RPS15A http://www.ncbi.nlm.nih.gov/gene/?term=6210 S15a mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018359 6210 RPS15A http://www.ncbi.nlm.nih.gov/gene/?term=6210 S15a mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018360 6217 RPS16 http://www.ncbi.nlm.nih.gov/gene/?term=6217 S16 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018361 6217 RPS16 http://www.ncbi.nlm.nih.gov/gene/?term=6217 S16 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018362 6218 RPS17 http://www.ncbi.nlm.nih.gov/gene/?term=6218 "DBA4L, RPS17L1, RPS17L2, S17, RPS17 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018363 622124 Gm20750 http://www.ncbi.nlm.nih.gov/gene/?term=622124 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018364 622129 Gm6288 http://www.ncbi.nlm.nih.gov/gene/?term=622129 EG622129 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018365 622208 Gm6297 http://www.ncbi.nlm.nih.gov/gene/?term=622208 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018366 6222 RPS18 http://www.ncbi.nlm.nih.gov/gene/?term=6222 "D6S218E, HKE3, KE-3, KE3, S18 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018367 6223 RPS19 http://www.ncbi.nlm.nih.gov/gene/?term=6223 "DBA, DBA1, S19 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018368 6223 RPS19 http://www.ncbi.nlm.nih.gov/gene/?term=6223 "DBA, DBA1, S19 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018369 6224 RPS20 http://www.ncbi.nlm.nih.gov/gene/?term=6224 S20 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018370 6224 RPS20 http://www.ncbi.nlm.nih.gov/gene/?term=6224 S20 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018371 6224 RPS20 http://www.ncbi.nlm.nih.gov/gene/?term=6224 S20 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018372 622675 Zfp827 http://www.ncbi.nlm.nih.gov/gene/?term=622675 "2810449M09Rik, D630040G17Rik, Znf827 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018373 6227 RPS21 http://www.ncbi.nlm.nih.gov/gene/?term=6227 "HLDF, S21 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018374 6228 RPS23 http://www.ncbi.nlm.nih.gov/gene/?term=6228 S23 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018375 622 BDH1 http://www.ncbi.nlm.nih.gov/gene/?term=622 "BDH, SDR9C1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018376 622 BDH1 http://www.ncbi.nlm.nih.gov/gene/?term=622 "BDH, SDR9C1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018377 6230 RPS25 http://www.ncbi.nlm.nih.gov/gene/?term=6230 S25 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018378 6231 RPS26 http://www.ncbi.nlm.nih.gov/gene/?term=6231 "DBA10, S26 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018379 6232 RPS27 http://www.ncbi.nlm.nih.gov/gene/?term=6232 "MPS-1, MPS1, S27 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018380 6233 RPS27A http://www.ncbi.nlm.nih.gov/gene/?term=6233 "CEP80, HEL112, S27A, UBA80, UBC, UBCEP1, UBCEP80 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018381 6233 RPS27A http://www.ncbi.nlm.nih.gov/gene/?term=6233 "CEP80, HEL112, S27A, UBA80, UBC, UBCEP1, UBCEP80 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018382 6234 RPS28 http://www.ncbi.nlm.nih.gov/gene/?term=6234 "DBA15, S28 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018383 6234 RPS28 http://www.ncbi.nlm.nih.gov/gene/?term=6234 "DBA15, S28 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018384 6235 RPS29 http://www.ncbi.nlm.nih.gov/gene/?term=6235 "DBA13, S29 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018385 6238 RRBP1 http://www.ncbi.nlm.nih.gov/gene/?term=6238 "ES/130, ES130, RRp, hES " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018386 6239 RREB1 http://www.ncbi.nlm.nih.gov/gene/?term=6239 "FINB, HNT, LZ321, RREB-1, Zep-1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018387 6239 RREB1 http://www.ncbi.nlm.nih.gov/gene/?term=6239 "FINB, HNT, LZ321, RREB-1, Zep-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018388 624086 A230045G11Rik http://www.ncbi.nlm.nih.gov/gene/?term=624086 EG624086 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018389 6240 RRM1 http://www.ncbi.nlm.nih.gov/gene/?term=6240 "R1, RIR1, RR1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018390 6240 RRM1 http://www.ncbi.nlm.nih.gov/gene/?term=6240 "R1, RIR1, RR1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018391 6240 RRM1 http://www.ncbi.nlm.nih.gov/gene/?term=6240 "R1, RIR1, RR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018392 6241 RRM2 http://www.ncbi.nlm.nih.gov/gene/?term=6241 "R2, RR2, RR2M " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018393 6241 RRM2 http://www.ncbi.nlm.nih.gov/gene/?term=6241 "R2, RR2, RR2M " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018394 6241 RRM2 http://www.ncbi.nlm.nih.gov/gene/?term=6241 "R2, RR2, RR2M " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018395 624295 LOC624295 http://www.ncbi.nlm.nih.gov/gene/?term=624295 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00018396 6242 RTKN http://www.ncbi.nlm.nih.gov/gene/?term=6242 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018397 6249 CLIP1 http://www.ncbi.nlm.nih.gov/gene/?term=6249 "CLIP, CLIP-17070, CYLN1, RSN, CLIP1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018398 6249 CLIP1 http://www.ncbi.nlm.nih.gov/gene/?term=6249 "CLIP, CLIP-17070, CYLN1, RSN, CLIP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018399 6249 CLIP1 http://www.ncbi.nlm.nih.gov/gene/?term=6249 "CLIP, CLIP-170, CLIP170, CYLN1, RSN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018400 625175 1700028E10Rik http://www.ncbi.nlm.nih.gov/gene/?term=625175 "A630054D14, Gm6561 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018401 6251 RSU1 http://www.ncbi.nlm.nih.gov/gene/?term=6251 RSP-1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018402 6252 RTN1 http://www.ncbi.nlm.nih.gov/gene/?term=6252 NSP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018403 6253 RTN2 http://www.ncbi.nlm.nih.gov/gene/?term=6253 "NSP2, NSPL1, NSPLI, SPG12 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018404 625424 Gm6583 http://www.ncbi.nlm.nih.gov/gene/?term=625424 EG625424 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018405 6256 RXRA http://www.ncbi.nlm.nih.gov/gene/?term=6256 NR2B1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018406 6257 RXRB http://www.ncbi.nlm.nih.gov/gene/?term=6257 "DAUDI6, H-2RIIBP, NR2B2, RCoR-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018407 6257 RXRB http://www.ncbi.nlm.nih.gov/gene/?term=6257 "DAUDI6, H-2RIIBP, NR2B2, RCoR-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018408 6259 RYK http://www.ncbi.nlm.nih.gov/gene/?term=6259 "D3S3195, JTK5, JTK5A1, RYK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018409 6259 RYK http://www.ncbi.nlm.nih.gov/gene/?term=6259 "D3S3195, JTK5, JTK5A1, RYK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018410 6259 RYK http://www.ncbi.nlm.nih.gov/gene/?term=6259 "D3S3195, JTK5, JTK5A, RYK1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018411 626000 Ccnd3-ps http://www.ncbi.nlm.nih.gov/gene/?term=626000 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018412 626832 Gm6710 http://www.ncbi.nlm.nih.gov/gene/?term=626832 "1600017I02Rik, 2310011F05Rik, 2900089K14Rik, 3100002L24Rik, WF-4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00018413 6271 S100A1 http://www.ncbi.nlm.nih.gov/gene/?term=6271 "S100, S100-alpha, S100A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018414 6272 SORT1 http://www.ncbi.nlm.nih.gov/gene/?term=6272 "Gp95, LDLCQ6, NT3, NTR3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018415 627488 Gm6763 http://www.ncbi.nlm.nih.gov/gene/?term=627488 "EG627488, Gm21293 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00018416 6275 S100A4 http://www.ncbi.nlm.nih.gov/gene/?term=6275 "18A2, 42A, CAPL, FSP1, MTS1, P9KA, PEL98 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018417 6277 S100A6 http://www.ncbi.nlm.nih.gov/gene/?term=6277 "2A9, 5B10, CABP, CACY, PRA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018418 6281 S100A10 http://www.ncbi.nlm.nih.gov/gene/?term=6281 "42C, ANX2L, ANX2LG, CAL1L, CLP11, Ca[1], GP11, P11, p10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018419 6281 S100A10 http://www.ncbi.nlm.nih.gov/gene/?term=6281 "42C, ANX2L, ANX2LG, CAL1L, CLP11, Ca[1], GP11, P11, p10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018420 6282 S100A11 http://www.ncbi.nlm.nih.gov/gene/?term=6282 "HEL-S-43, MLN70, S100C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018421 6282 S100A11 http://www.ncbi.nlm.nih.gov/gene/?term=6282 "HEL-S-43, MLN70, S100C " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018422 6282 S100A11 http://www.ncbi.nlm.nih.gov/gene/?term=6282 "HEL-S-43, MLN70, S100C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018423 6284 S100A13 http://www.ncbi.nlm.nih.gov/gene/?term=6284 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018424 6284 S100A13 http://www.ncbi.nlm.nih.gov/gene/?term=6284 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018425 6285 S100B http://www.ncbi.nlm.nih.gov/gene/?term=6285 "NEF, S100, S100-B, S100beta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018426 6286 S100P http://www.ncbi.nlm.nih.gov/gene/?term=6286 MIG9 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018427 6286 S100P http://www.ncbi.nlm.nih.gov/gene/?term=6286 MIG9 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018428 6293 VPS52 http://www.ncbi.nlm.nih.gov/gene/?term=6293 "ARE1, SAC2, SACM2L, dJ1033B10.5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018429 6293 VPS52 http://www.ncbi.nlm.nih.gov/gene/?term=6293 "ARE1, SAC2, SACM2L, dJ1033B10.5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018430 629481 Gm29687 http://www.ncbi.nlm.nih.gov/gene/?term=629481 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018431 6294 SAFB http://www.ncbi.nlm.nih.gov/gene/?term=6294 "HAP, HET, SAB-B1, SAF-B, SAF-B11, SAFB " lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00018432 6295 SAG http://www.ncbi.nlm.nih.gov/gene/?term=6295 "RP47, S-AG " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018433 6296 ACSM3 http://www.ncbi.nlm.nih.gov/gene/?term=6296 "SA, SAH " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018434 6297 SALL2 http://www.ncbi.nlm.nih.gov/gene/?term=6297 "COLB, HSAL2, Sal-2, ZNF795, p150(Sal2) " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018435 6301 SARS http://www.ncbi.nlm.nih.gov/gene/?term=6301 "SERRS, SERS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018436 6301 SARS http://www.ncbi.nlm.nih.gov/gene/?term=6301 "SERRS, SERS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018437 63027 SLC22A23 http://www.ncbi.nlm.nih.gov/gene/?term=63027 C6orf85 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018438 6302 TSPAN31 http://www.ncbi.nlm.nih.gov/gene/?term=6302 SAS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018439 6302 TSPAN31 http://www.ncbi.nlm.nih.gov/gene/?term=6302 SAS mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018440 63035 BCORL1 http://www.ncbi.nlm.nih.gov/gene/?term=63035 "BCoR-L1, CXorf10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018441 6303 SAT1 http://www.ncbi.nlm.nih.gov/gene/?term=6303 "DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018442 6303 SAT1 http://www.ncbi.nlm.nih.gov/gene/?term=6303 "DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018443 6303 SAT1 http://www.ncbi.nlm.nih.gov/gene/?term=6303 "DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018444 6303 SAT1 http://www.ncbi.nlm.nih.gov/gene/?term=6303 "DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018445 6304 SATB1 http://www.ncbi.nlm.nih.gov/gene/?term=6304 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018446 6305 SBF1 http://www.ncbi.nlm.nih.gov/gene/?term=6305 "CMT4B3, DENND7A, MTMR5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018447 6305 SBF1 http://www.ncbi.nlm.nih.gov/gene/?term=6305 "CMT4B3, DENND7A, MTMR5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018448 6307 MSMO1 http://www.ncbi.nlm.nih.gov/gene/?term=6307 "DESP4, ERG25, MCCPD, SC4MOL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018449 6307 MSMO1 http://www.ncbi.nlm.nih.gov/gene/?term=6307 "DESP4, ERG25, MCCPD, SC4MOL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018450 6307 MSMO1 http://www.ncbi.nlm.nih.gov/gene/?term=6307 "DESP4, ERG25, MCCPD, SC4MOL " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018451 6307 MSMO1 http://www.ncbi.nlm.nih.gov/gene/?term=6307 "DESP4, ERG25, MCCPD, SC4MOL " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018452 6307 MSMO1 http://www.ncbi.nlm.nih.gov/gene/?term=6307 "DESP4, ERG25, SC4MOL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018453 6309 SC5D http://www.ncbi.nlm.nih.gov/gene/?term=6309 "ERG3, S5DESL, SC5D " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018454 6309 SC5D http://www.ncbi.nlm.nih.gov/gene/?term=6309 "ERG3, S5DESL, SC5D " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018455 6309 SC5D http://www.ncbi.nlm.nih.gov/gene/?term=6309 "ERG3, S5DESL, SC5D " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018456 6309 SC5D http://www.ncbi.nlm.nih.gov/gene/?term=6309 "ERG3, S5DES, SC5DL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018457 631145 Fam90a1b http://www.ncbi.nlm.nih.gov/gene/?term=631145 4932442L08Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018458 6311 ATXN2 http://www.ncbi.nlm.nih.gov/gene/?term=6311 "ASL13, ATX2, SCA2, TNRC13 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018459 6311 ATXN2 http://www.ncbi.nlm.nih.gov/gene/?term=6311 "ASL13, ATX2, SCA2, TNRC13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018460 6314 ATXN7 http://www.ncbi.nlm.nih.gov/gene/?term=6314 "ADCAII, OPCA3, SCA7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018461 6319 SCD http://www.ncbi.nlm.nih.gov/gene/?term=6319 "FADS5, MSTP0081, SCDOS, hSCD1, SCD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018462 6319 SCD http://www.ncbi.nlm.nih.gov/gene/?term=6319 "FADS5, MSTP0081, SCDOS, hSCD1, SCD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018463 6319 SCD http://www.ncbi.nlm.nih.gov/gene/?term=6319 "FADS5, MSTP008, SCD1, SCDOS, hSCD1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018464 6320 CLEC11A http://www.ncbi.nlm.nih.gov/gene/?term=6320 "CLECSF3, LSLCL, P47, SCGF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018465 632687 March10 http://www.ncbi.nlm.nih.gov/gene/?term=632687 "4933417C16Rik, AV039223, OTTMUSG00000002847, Rnf190 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018466 6335 SCN9A http://www.ncbi.nlm.nih.gov/gene/?term=6335 "ETHA, FEB3B, GEFSP7, HSAN2D, NE-NA, NENA, Nav1.7, PN1, SFNP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018467 6337 SCNN1A http://www.ncbi.nlm.nih.gov/gene/?term=6337 "BESC2, ENaCa, ENaCalpha, SCNEA, SCNN1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018468 633 BGN http://www.ncbi.nlm.nih.gov/gene/?term=633 "DSPG1, PG-S1, PGI, SLRR1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018469 6341 SCO1 http://www.ncbi.nlm.nih.gov/gene/?term=6341 SCOD1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018470 6342 SCP2 http://www.ncbi.nlm.nih.gov/gene/?term=6342 "NLTP, NSL-TP, SCP-2, SCP-CHI, SCP-X, SCPX " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018471 6342 SCP2 http://www.ncbi.nlm.nih.gov/gene/?term=6342 "NLTP, NSL-TP, SCP-2, SCP-CHI, SCP-X, SCPX " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018472 6342 SCP2 http://www.ncbi.nlm.nih.gov/gene/?term=6342 "NLTP, NSL-TP, SCP-2, SCP-CHI, SCP-X, SCPX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018473 634 CEACAM1 http://www.ncbi.nlm.nih.gov/gene/?term=634 "BGP, BGP1, BGPI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018474 635253 Usp51 http://www.ncbi.nlm.nih.gov/gene/?term=635253 AV136873 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018475 6359 CCL15 http://www.ncbi.nlm.nih.gov/gene/?term=6359 "HCC-2, HMRP-2B, LKN-1, LKN1, MIP-1 delta, MIP-1D, MIP-5, MRP-2B, NCC-3, NCC3, SCYA15, SCYL3, SY15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018476 6360 CCL16 http://www.ncbi.nlm.nih.gov/gene/?term=6360 "CKb12, HCC-4, ILINCK, LCC-1, LEC, LMC, Mtn-1, NCC-4, NCC4, SCYA16, SCYL4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018477 6360 CCL16 http://www.ncbi.nlm.nih.gov/gene/?term=6360 "CKb12, HCC-4, ILINCK, LCC-1, LEC, LMC, Mtn-1, NCC-4, NCC4, SCYA16, SCYL4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018478 6360 CCL16 http://www.ncbi.nlm.nih.gov/gene/?term=6360 "CKb12, HCC-4, ILINCK, LCC-1, LEC, LMC, Mtn-1, NCC-4, NCC4, SCYA16, SCYL4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018479 6363 CCL19 http://www.ncbi.nlm.nih.gov/gene/?term=6363 "CKb11, ELC, MIP-3b, MIP3B, SCYA19 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018480 6367 CCL22 http://www.ncbi.nlm.nih.gov/gene/?term=6367 "A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018481 6367 CCL22 http://www.ncbi.nlm.nih.gov/gene/?term=6367 "A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018482 636931 Trim71 http://www.ncbi.nlm.nih.gov/gene/?term=636931 "2610206G21Rik, AL022943, Gm1127, Lin41, lin-41, mLin41, mlin-41 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018483 637008 Gm11793 http://www.ncbi.nlm.nih.gov/gene/?term=637008 OTTMUSG00000004294 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00018484 6370 CCL25 http://www.ncbi.nlm.nih.gov/gene/?term=6370 "Ckb15, SCYA25, TECK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018485 6375 XCL1 http://www.ncbi.nlm.nih.gov/gene/?term=6375 "ATAC, LPTN, LTN, SCM-1, SCM-1a, SCM1, SCM1A, SCYC1 " mRNA Homo sapiens 11696436 Dendrite Monocyte qRT-PCR Lptn mRNA expression was investigated at different stages of dendritic cell differentiation and maturation. RT-PCR analysis of freshly isolated monocytes and day 3-harvested immature dendritic cells showed no expression of Lptn mRNA. RLID00018486 637 BID http://www.ncbi.nlm.nih.gov/gene/?term=637 FP497 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018487 637 BID http://www.ncbi.nlm.nih.gov/gene/?term=637 FP497 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018488 637 BID http://www.ncbi.nlm.nih.gov/gene/?term=637 FP497 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018489 63826 SRR http://www.ncbi.nlm.nih.gov/gene/?term=63826 "ILV1, ISO1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018490 6382 SDC1 http://www.ncbi.nlm.nih.gov/gene/?term=6382 "CD138, SDC, SYND1, syndecan " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018491 6382 SDC1 http://www.ncbi.nlm.nih.gov/gene/?term=6382 "CD138, SDC, SYND1, syndecan " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018492 63830 Kcnq1ot1 http://www.ncbi.nlm.nih.gov/gene/?term=63830 "Kvlqt1-as, Lit1, Tssc8 " lncRNA Mus musculus 18951091 Nucleus Placenta|Liver In situ hybridization|qRT-PCR "To address this, we have analyzed the nuclear and cytoplasmic levels of Kcnq1ot1 in MEFs using RPA and found that it is exclusively localized in the nuclear compartment, consistent with its role in transcriptional silencing ( Figure 1D). " RLID00018493 63830 Kcnq1ot1 http://www.ncbi.nlm.nih.gov/gene/?term=63830 "Kvlqt1-as, Lit1, Tssc8 " lncRNA Mus musculus 19144718 Nucleus Fibroblasts In situ hybridization|qRT-PCR "Here, we show that Kcnq1ot1 is transcribed by RNA polymerase II, is unspliced, is relatively stable and is localised in the nucleus. " RLID00018494 63830 Kcnq1ot1 http://www.ncbi.nlm.nih.gov/gene/?term=63830 "Kvlqt1-as, Lit1, Tssc8 " lncRNA Mus musculus 21775415 Nucleus Embryonic stem cell In situ hybridization|qRT-PCR "Short hairpin RNA (shRNA)-mediated Kcnq1ot1 RNA depletion in embryonic stem (ES), trophoblast stem (TS) and extra-embryonic endoderm stem (XEN) cells had no observable effect on imprinted gene expression, nor on ICR DNA methylation, although a significant decrease in Kcnq1ot1 nuclear volume was observed. " RLID00018495 63830 Kcnq1ot1 http://www.ncbi.nlm.nih.gov/gene/?term=63830 "Kvlqt1-as, Lit1, Tssc8 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018496 63830 Kcnq1ot1 http://www.ncbi.nlm.nih.gov/gene/?term=63830 "Kvlqt1-as, Lit1, Tssc8 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018497 6383 SDC2 http://www.ncbi.nlm.nih.gov/gene/?term=6383 "CD362, HSPG, HSPG1, SYND2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018498 6383 SDC2 http://www.ncbi.nlm.nih.gov/gene/?term=6383 "CD362, HSPG, HSPG1, SYND2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018499 6385 SDC4 http://www.ncbi.nlm.nih.gov/gene/?term=6385 SYND4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018500 6385 SDC4 http://www.ncbi.nlm.nih.gov/gene/?term=6385 SYND4 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018501 6385 SDC4 http://www.ncbi.nlm.nih.gov/gene/?term=6385 SYND4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018502 63868 Hspd1 http://www.ncbi.nlm.nih.gov/gene/?term=63868 "Hsp60-30p, Hspd1 " mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00018503 63868 Hspd1 http://www.ncbi.nlm.nih.gov/gene/?term=63868 "Hsp60-30p, Hspd1 " mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00018504 6386 SDCBP http://www.ncbi.nlm.nih.gov/gene/?term=6386 "MDA-9, MDA9, ST1, SYCL, TACIP18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018505 6386 SDCBP http://www.ncbi.nlm.nih.gov/gene/?term=6386 "MDA-9, MDA9, ST1, SYCL, TACIP18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018506 63872 Zfp296 http://www.ncbi.nlm.nih.gov/gene/?term=63872 2210018A16Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018507 63875 MRPL17 http://www.ncbi.nlm.nih.gov/gene/?term=63875 "L17mt, LIP2, MRP-L17, MRP-L26, RPL17L, RPML26 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018508 63877 FAM204A http://www.ncbi.nlm.nih.gov/gene/?term=63877 "C10orf84, bA319I23.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018509 63877 FAM204A http://www.ncbi.nlm.nih.gov/gene/?term=63877 "C10orf84, bA319I23.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018510 63877 FAM204A http://www.ncbi.nlm.nih.gov/gene/?term=63877 "C10orf84, bA319I23.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018511 6387 CXCL12 http://www.ncbi.nlm.nih.gov/gene/?term=6387 "IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018512 6388 SDF2 http://www.ncbi.nlm.nih.gov/gene/?term=6388 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018513 6388 SDF2 http://www.ncbi.nlm.nih.gov/gene/?term=6388 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018514 6388 SDF2 http://www.ncbi.nlm.nih.gov/gene/?term=6388 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018515 63891 RNF123 http://www.ncbi.nlm.nih.gov/gene/?term=63891 "FP1477, KPC1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018516 63892 THADA http://www.ncbi.nlm.nih.gov/gene/?term=63892 GITA mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018517 63892 THADA http://www.ncbi.nlm.nih.gov/gene/?term=63892 GITA mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018518 63894 VIPAS39 http://www.ncbi.nlm.nih.gov/gene/?term=63894 "C14orf133, SPE-39, SPE39, VIPAR, VPS16B, hSPE-39 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018519 63897 HEATR6 http://www.ncbi.nlm.nih.gov/gene/?term=63897 ABC1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018520 6389 SDHA http://www.ncbi.nlm.nih.gov/gene/?term=6389 "CMD1GG, FP, PGL5, SDH1, SDH2, SDHF " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018521 6389 SDHA http://www.ncbi.nlm.nih.gov/gene/?term=6389 "CMD1GG, FP, PGL5, SDH1, SDH2, SDHF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018522 638 BIK http://www.ncbi.nlm.nih.gov/gene/?term=638 "BIP1, BP4, NBK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018523 63901 FAM111A http://www.ncbi.nlm.nih.gov/gene/?term=63901 "GCLEB, KCS2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018524 63905 MANBAL http://www.ncbi.nlm.nih.gov/gene/?term=63905 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018525 63905 MANBAL http://www.ncbi.nlm.nih.gov/gene/?term=63905 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018526 63906 GPATCH3 http://www.ncbi.nlm.nih.gov/gene/?term=63906 GPATC3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018527 6390 SDHB http://www.ncbi.nlm.nih.gov/gene/?term=6390 "CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018528 6390 SDHB http://www.ncbi.nlm.nih.gov/gene/?term=6390 "CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018529 63910 SLC17A9 http://www.ncbi.nlm.nih.gov/gene/?term=63910 "C20orf59, POROK8, VNUT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018530 63913 Fam129a http://www.ncbi.nlm.nih.gov/gene/?term=63913 "AI256368, AU019833, Niban " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018531 63915 BLOC1S5 http://www.ncbi.nlm.nih.gov/gene/?term=63915 "BLOS5, MU, MUTED " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018532 6391 SDHC http://www.ncbi.nlm.nih.gov/gene/?term=6391 "CYB560, CYBL, PGL3, QPS1, SDH3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018533 6391 SDHC http://www.ncbi.nlm.nih.gov/gene/?term=6391 "CYB560, CYBL, PGL3, QPS1, SDH3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018534 63920 ZBED8 http://www.ncbi.nlm.nih.gov/gene/?term=63920 "Buster3, C5orf54 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018535 63922 CHTF18 http://www.ncbi.nlm.nih.gov/gene/?term=63922 "C16orf41, C321D2.2, C321D2.3, C321D2.4, CHL12, Ctf18, RUVBL " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018536 63924 CIDEC http://www.ncbi.nlm.nih.gov/gene/?term=63924 "CIDE-3, CIDE3, FPLD5, FSP27 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018537 63925 ZNF335 http://www.ncbi.nlm.nih.gov/gene/?term=63925 "MCPH10, NIF-1, NIF1, NIF2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018538 63929 XPNPEP3 http://www.ncbi.nlm.nih.gov/gene/?term=63929 "APP3, ICP55, NPHPL1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018539 63929 XPNPEP3 http://www.ncbi.nlm.nih.gov/gene/?term=63929 "APP3, ICP55, NPHPL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018540 6392 SDHD http://www.ncbi.nlm.nih.gov/gene/?term=6392 "CBT1, CII-4, CWS3, PGL, PGL1, QPs3, SDH4, cybS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018541 6392 SDHD http://www.ncbi.nlm.nih.gov/gene/?term=6392 "CBT1, CII-4, CWS3, PGL, PGL1, QPs3, SDH4, cybS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018542 63931 MRPS14 http://www.ncbi.nlm.nih.gov/gene/?term=63931 "DJ262D12.2, HSMRPS14, MRP-S14, S14mt " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018543 63932 CXorf56 http://www.ncbi.nlm.nih.gov/gene/?term=63932 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018544 63933 MCUR1 http://www.ncbi.nlm.nih.gov/gene/?term=63933 "C6orf79, CCDC90A " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018545 63933 MCUR1 http://www.ncbi.nlm.nih.gov/gene/?term=63933 "C6orf79, CCDC90A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018546 639396 Gm7265 http://www.ncbi.nlm.nih.gov/gene/?term=639396 EG639396 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018547 63939 FAM217B http://www.ncbi.nlm.nih.gov/gene/?term=63939 "C20orf177, dJ551D2.5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018548 63940 GPSM3 http://www.ncbi.nlm.nih.gov/gene/?term=63940 "AGS4, C6orf9, G18, G18.1a, G18.1b, G18.2, NG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018549 63943 FKBPL http://www.ncbi.nlm.nih.gov/gene/?term=63943 "DIR1, FKBP4, NG7, WISP39 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018550 63943 FKBPL http://www.ncbi.nlm.nih.gov/gene/?term=63943 "DIR1, FKBP4, NG7, WISP39 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018551 6396 SEC13 http://www.ncbi.nlm.nih.gov/gene/?term=6396 "D3S1231EL1, SEC13R, npp-20, SEC13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018552 6396 SEC13 http://www.ncbi.nlm.nih.gov/gene/?term=6396 "D3S1231E, SEC13L1, SEC13R, npp-20 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018553 63971 KIF13A http://www.ncbi.nlm.nih.gov/gene/?term=63971 "RBKIN, bA500C11.2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018554 63977 PRDM15 http://www.ncbi.nlm.nih.gov/gene/?term=63977 "C21orf83, PFM15, ZNF298 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018555 63979 FIGNL1 http://www.ncbi.nlm.nih.gov/gene/?term=63979 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018556 6397 SEC14L1 http://www.ncbi.nlm.nih.gov/gene/?term=6397 "PRELID4A, SEC14L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018557 63982 ANO3 http://www.ncbi.nlm.nih.gov/gene/?term=63982 "C11orf25, DYT23, DYT24, GENX-3947, TMEM16C " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018558 63993 Slc5a7 http://www.ncbi.nlm.nih.gov/gene/?term=63993 CHT1 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018559 6399 TRAPPC2 http://www.ncbi.nlm.nih.gov/gene/?term=6399 "MIP2A, SEDL, SEDTP1, TRS20, ZNF547L, hYP38334, TRAPPC2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018560 6399 TRAPPC2 http://www.ncbi.nlm.nih.gov/gene/?term=6399 "MIP2A, SEDL, SEDTP1, TRS20, ZNF547L, hYP38334, TRAPPC2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018561 6399 TRAPPC2 http://www.ncbi.nlm.nih.gov/gene/?term=6399 "MIP2A, SEDL, SEDTP1, TRS20, ZNF547L, hYP38334, TRAPPC2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018562 6399 TRAPPC2 http://www.ncbi.nlm.nih.gov/gene/?term=6399 "MIP2A, SEDL, SEDT, TRAPPC2P1, TRS20, ZNF547L, hYP38334 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018563 64008 Aqp9 http://www.ncbi.nlm.nih.gov/gene/?term=64008 "1700020I22Rik, AI266899, AQP-9 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018564 64009 Syne1 http://www.ncbi.nlm.nih.gov/gene/?term=64009 "8B, A330049M09Rik, BE692247, C130039F11Rik, CPG2, Myne1, mKIAA1756 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018565 6400 SEL1L http://www.ncbi.nlm.nih.gov/gene/?term=6400 "PRO1063, SEL1-LIKE1, SEL1L " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018566 6400 SEL1L http://www.ncbi.nlm.nih.gov/gene/?term=6400 "PRO1063, SEL1-LIKE, SEL1L1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018567 6405 SEMA3F http://www.ncbi.nlm.nih.gov/gene/?term=6405 "SEMA-IV, SEMA4, SEMAK " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018568 64062 RBM26 http://www.ncbi.nlm.nih.gov/gene/?term=64062 "ARRS2, C13orf10, PPP1R132, PRO1777, SE70-2, ZC3H17 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018569 64065 PERP http://www.ncbi.nlm.nih.gov/gene/?term=64065 "KCP1, KRTCAP1, PIGPC1, THW, dJ496H19.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018570 64065 PERP http://www.ncbi.nlm.nih.gov/gene/?term=64065 "KCP1, KRTCAP1, PIGPC1, THW, dJ496H19.1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018571 64073 C19orf33 http://www.ncbi.nlm.nih.gov/gene/?term=64073 "H2RSP, IMUP, IMUP-1, IMUP-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018572 64077 LHPP http://www.ncbi.nlm.nih.gov/gene/?term=64077 HDHD2B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018573 64077 LHPP http://www.ncbi.nlm.nih.gov/gene/?term=64077 HDHD2B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018574 6407 SEMG2 http://www.ncbi.nlm.nih.gov/gene/?term=6407 SGII mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018575 64081 PBLD http://www.ncbi.nlm.nih.gov/gene/?term=64081 "HEL-S-306, MAWBP, MAWDBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018576 64083 GOLPH3 http://www.ncbi.nlm.nih.gov/gene/?term=64083 "GOPP1, GPP34, MIDAS, Vps74 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018577 64083 GOLPH3 http://www.ncbi.nlm.nih.gov/gene/?term=64083 "GOPP1, GPP34, MIDAS, Vps74 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018578 64083 GOLPH3 http://www.ncbi.nlm.nih.gov/gene/?term=64083 "GOPP1, GPP34, MIDAS, Vps74 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018579 64087 MCCC2 http://www.ncbi.nlm.nih.gov/gene/?term=64087 MCCB mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018580 64087 MCCC2 http://www.ncbi.nlm.nih.gov/gene/?term=64087 MCCB mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018581 64087 MCCC2 http://www.ncbi.nlm.nih.gov/gene/?term=64087 MCCB mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018582 64087 MCCC2 http://www.ncbi.nlm.nih.gov/gene/?term=64087 MCCB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018583 64092 SAMSN1 http://www.ncbi.nlm.nih.gov/gene/?term=64092 "HACS1, NASH1, SASH2, SH3D6B, SLy2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018584 64094 SMOC2 http://www.ncbi.nlm.nih.gov/gene/?term=64094 "DTDP1, MST117, MSTP117, MSTP140, SMAP2, bA270C4A.1, bA37D8.1, dJ421D16.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018585 64110 MAGEF1 http://www.ncbi.nlm.nih.gov/gene/?term=64110 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018586 64110 MAGEF1 http://www.ncbi.nlm.nih.gov/gene/?term=64110 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018587 64112 MOAP1 http://www.ncbi.nlm.nih.gov/gene/?term=64112 "MAP-1, PNMA4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018588 64112 MOAP1 http://www.ncbi.nlm.nih.gov/gene/?term=64112 "MAP-1, PNMA4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018589 64113 Moap1 http://www.ncbi.nlm.nih.gov/gene/?term=64113 "AA987038, Map-1, Pnma4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018590 64114 TMBIM1 http://www.ncbi.nlm.nih.gov/gene/?term=64114 "LFG3, MST100, MSTP100, PP1201, RECS1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018591 64115 C10orf54 http://www.ncbi.nlm.nih.gov/gene/?term=64115 "B7-H5, B7H5, DD1alpha, GI24, PP2135, SISP1, VISTA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018592 64116 SLC39A8 http://www.ncbi.nlm.nih.gov/gene/?term=64116 "BIGM103, CDG2N, LZT-Hs6, PP3105, ZIP8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018593 64118 DUS1L http://www.ncbi.nlm.nih.gov/gene/?term=64118 "DUS1, PP3111 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018594 64118 DUS1L http://www.ncbi.nlm.nih.gov/gene/?term=64118 "DUS1, PP3111 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018595 64121 RRAGC http://www.ncbi.nlm.nih.gov/gene/?term=64121 "GTR2, RAGC, TIB929 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018596 64129 TINAGL1 http://www.ncbi.nlm.nih.gov/gene/?term=64129 "ARG1, LCN7, LIECG3, TINAGRP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018597 64131 XYLT1 http://www.ncbi.nlm.nih.gov/gene/?term=64131 "DBQD2, PXYLT1, XT-I, XT1, XTI, XYLTI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018598 641368 Spint5 http://www.ncbi.nlm.nih.gov/gene/?term=641368 "Gm14316, OTTMUSG00000016293 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018599 64144 Mllt1 http://www.ncbi.nlm.nih.gov/gene/?term=64144 "AA407901, BAM11, ENL, LTG19 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018600 641451 SNORA19 http://www.ncbi.nlm.nih.gov/gene/?term=641451 ACA19 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018601 64145 RBSN http://www.ncbi.nlm.nih.gov/gene/?term=64145 "Rabenosyn-5, ZFYVE20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018602 64145 RBSN http://www.ncbi.nlm.nih.gov/gene/?term=64145 "Rabenosyn-5, ZFYVE20 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018603 64146 PDF http://www.ncbi.nlm.nih.gov/gene/?term=64146 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018604 64147 KIF9 http://www.ncbi.nlm.nih.gov/gene/?term=64147 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018605 64147 KIF9 http://www.ncbi.nlm.nih.gov/gene/?term=64147 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018606 64149 C17orf75 http://www.ncbi.nlm.nih.gov/gene/?term=64149 NJMU-R1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018607 64149 C17orf75 http://www.ncbi.nlm.nih.gov/gene/?term=64149 NJMU-R1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018608 6414 SEPP1 http://www.ncbi.nlm.nih.gov/gene/?term=6414 "SELP, SEPP, SeP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018609 6414 SEPP1 http://www.ncbi.nlm.nih.gov/gene/?term=6414 "SELP, SEPP, SeP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018610 6414 SEPP1 http://www.ncbi.nlm.nih.gov/gene/?term=6414 "SELP, SEPP, SeP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018611 64151 NCAPG http://www.ncbi.nlm.nih.gov/gene/?term=64151 "CAPG, CHCG, NY-MEL-3, YCG1 " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00018612 64151 NCAPG http://www.ncbi.nlm.nih.gov/gene/?term=64151 "CAPG, CHCG, NY-MEL-3, YCG1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018613 64156 Uba52 http://www.ncbi.nlm.nih.gov/gene/?term=64156 "Rps27a, Ubb " mRNA Rattus norvegicus 25301173 Dendrite Hippocampus In situ hybridization "Figure 2: In situ hybridization reveals species-specific patterns of localization in neuronal dendrites. Fluorescent Microscopy evaluation of biotin-conjugated oligoprobes on paraformaldehyde fixed 14-day cultured rat and mouse cortical neurons hybridized with nine biotin-conjugated oligoprobes detected with streptadivin-Alexa Fluor 568 (Invitrogen). For each probe images set, the small bottom left corner panels represent MAP2 immuno-staining. Scale bar = 20um. (A), Probes against SFRS16, ARHGDIA and HNRPK transcripts show higher dendritic localization in mouse neurons than in rat neurons (Red box). (B), Probes against ZFP410, COMMD3 and RSP6 transcripts show higher dendritic localization in rat neurons than in mouse neurons (Blue box). (C), Probes against UBA52, OLFM1 and H2AFZ transcripts show high dendritic localization in both rat and mouse neurons (Black box). Data are collected from Figure 2. " RLID00018614 64158 Tuba1a http://www.ncbi.nlm.nih.gov/gene/?term=64158 Tuba1 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00018615 64158 Tuba1a http://www.ncbi.nlm.nih.gov/gene/?term=64158 Tuba1 mRNA Rattus norvegicus 2148487 Cell body Neuron In situ hybridization "In contrast, mRNAs encoding GAP-43 and alpha-tubulin were restricted to the cell body and largely excluded from dendrites as well as axons. " RLID00018616 6415 SEPW1 http://www.ncbi.nlm.nih.gov/gene/?term=6415 selW mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018617 6415 SEPW1 http://www.ncbi.nlm.nih.gov/gene/?term=6415 selW mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018618 6415 SEPW1 http://www.ncbi.nlm.nih.gov/gene/?term=6415 selW mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018619 641638 SNHG6 http://www.ncbi.nlm.nih.gov/gene/?term=641638 "HBII-276HG, NCRNA00058, U87HG " lncRNA Homo sapiens 16226852 Cytoplasm HeLa cell Northern blot We investigated the cellular localization of the U87HG RNA. Human HeLa cells were fractionated into nuclear and cytoplasmic fractions. U87HG RNA was detected mainly in the cytoplasm (Fig. 4). RLID00018620 641638 SNHG6 http://www.ncbi.nlm.nih.gov/gene/?term=641638 "HBII-276HG, NCRNA00058, U87HG " lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018621 64168 NECAB1 http://www.ncbi.nlm.nih.gov/gene/?term=64168 "EFCBP1, STIP-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018622 641700 ECSCR http://www.ncbi.nlm.nih.gov/gene/?term=641700 "ARIA, ECSM2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018623 64172 OSGEPL1 http://www.ncbi.nlm.nih.gov/gene/?term=64172 Qri7 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018624 64174 DPEP2 http://www.ncbi.nlm.nih.gov/gene/?term=64174 MBD2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018625 64175 P3H1 http://www.ncbi.nlm.nih.gov/gene/?term=64175 "GROS1, LEPRE1, OI8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018626 6418 SET http://www.ncbi.nlm.nih.gov/gene/?term=6418 "2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018627 6418 SET http://www.ncbi.nlm.nih.gov/gene/?term=6418 "2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018628 6418 SET http://www.ncbi.nlm.nih.gov/gene/?term=6418 "2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018629 6419 SETMAR http://www.ncbi.nlm.nih.gov/gene/?term=6419 "HsMar1, METNASE, Mar1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018630 641 BLM http://www.ncbi.nlm.nih.gov/gene/?term=641 "BS, RECQ2, RECQL2, RECQL3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018631 64202 Calr http://www.ncbi.nlm.nih.gov/gene/?term=64202 mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00018632 64202 Calr http://www.ncbi.nlm.nih.gov/gene/?term=64202 mRNA Rattus norvegicus 20308067 Axon Neuron Fluorescence in situ hybridization "MRNAs encoding the endoplasmic reticulum chaperone proteins calreticulin and Grp78/BiP were previously detected in sensory axons by RT-PCR and array hybridization (7, 30). Because these analyses used lysed axons that could contain proximal axonal segments, we used FISH to directly visualize the mRNAs in dissociated cultures of DRG neurons. DRG neurons showed punctate FISH signals for beta-actin, calreticulin, and Grp78/BiP mRNAs that extended into growth cones (Fig. 1A). This granular distribution is similar to other mRNAs localizing to dendrites and axons (21).mRNAs encoding the endoplasmic reticulum chaperone proteins calreticulin and Grp78/BiP were previously detected in sensory axons by RT-PCR and array hybridization (7, 30). Because these analyses used lysed axons that could contain proximal axonal segments, we used FISH to directly visualize the mRNAs in dissociated cultures of DRG neurons. DRG neurons showed punctate FISH signals for beta-actin, calreticulin, and Grp78/BiP mRNAs that extended into growth cones (Fig. 1A). This granular distribution is similar to other mRNAs localizing to dendrites and axons (21). " RLID00018633 64202 Calr http://www.ncbi.nlm.nih.gov/gene/?term=64202 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00018634 64207 IRF2BPL http://www.ncbi.nlm.nih.gov/gene/?term=64207 "C14orf4, EAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018635 64208 POPDC3 http://www.ncbi.nlm.nih.gov/gene/?term=64208 "POP3, bA355M14.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018636 64210 MMS19 http://www.ncbi.nlm.nih.gov/gene/?term=64210 "MET18L, hMMS19, MMS19 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018637 64210 MMS19 http://www.ncbi.nlm.nih.gov/gene/?term=64210 "MET18, MMS19L, hMMS19 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018638 64213 St7 http://www.ncbi.nlm.nih.gov/gene/?term=64213 "9430001H04Rik, Fam4a2, HELG, RAY1, SEN4, TSG7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018639 64215 DNAJC1 http://www.ncbi.nlm.nih.gov/gene/?term=64215 "DNAJL1, ERdj1, HTJ1, MTJ1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018640 64215 DNAJC1 http://www.ncbi.nlm.nih.gov/gene/?term=64215 "DNAJL1, ERdj1, HTJ1, MTJ1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018641 64216 TFB2M http://www.ncbi.nlm.nih.gov/gene/?term=64216 "Hkp1, mtTFB2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018642 64216 TFB2M http://www.ncbi.nlm.nih.gov/gene/?term=64216 "Hkp1, mtTFB2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018643 6421 SFPQ http://www.ncbi.nlm.nih.gov/gene/?term=6421 "POMP100, PPP1R140, PSF " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018644 64222 TOR3A http://www.ncbi.nlm.nih.gov/gene/?term=64222 "ADIR, ADIR2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018645 64224 HERPUD2 http://www.ncbi.nlm.nih.gov/gene/?term=64224 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018646 64224 HERPUD2 http://www.ncbi.nlm.nih.gov/gene/?term=64224 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018647 64225 ATL2 http://www.ncbi.nlm.nih.gov/gene/?term=64225 "ARL3IP2, ARL6IP2, atlastin2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018648 64225 ATL2 http://www.ncbi.nlm.nih.gov/gene/?term=64225 "ARL3IP2, ARL6IP2, atlastin2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018649 642273 FAM110C http://www.ncbi.nlm.nih.gov/gene/?term=642273 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018650 6422 SFRP1 http://www.ncbi.nlm.nih.gov/gene/?term=6422 "FRP, FRP-1, FRP1, FrzA, SARP2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018651 64231 MS4A6A http://www.ncbi.nlm.nih.gov/gene/?term=64231 "4SPAN3, 4SPAN3.2, CD20L3, CDA01, MS4A6, MST090, MSTP090 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018652 64236 PDLIM2 http://www.ncbi.nlm.nih.gov/gene/?term=64236 "MYSTIQUE, SLIM " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018653 64236 PDLIM2 http://www.ncbi.nlm.nih.gov/gene/?term=64236 "MYSTIQUE, SLIM " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018654 6423 SFRP2 http://www.ncbi.nlm.nih.gov/gene/?term=6423 "FRP-2, SARP1, SDF-5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018655 642475 MROH6 http://www.ncbi.nlm.nih.gov/gene/?term=642475 C8orf73 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018656 6426 SRSF1 http://www.ncbi.nlm.nih.gov/gene/?term=6426 "ASF, SF2, SF2p33, SFRS1, SRp30a " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018657 6426 SRSF1 http://www.ncbi.nlm.nih.gov/gene/?term=6426 "ASF, SF2, SF2p33, SFRS1, SRp30a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018658 6427 SRSF2 http://www.ncbi.nlm.nih.gov/gene/?term=6427 "PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018659 64282 PAPD5 http://www.ncbi.nlm.nih.gov/gene/?term=64282 TRF4-2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018660 64282 PAPD5 http://www.ncbi.nlm.nih.gov/gene/?term=64282 TRF4-2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018661 64284 RAB17 http://www.ncbi.nlm.nih.gov/gene/?term=64284 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018662 64285 RHBDF1 http://www.ncbi.nlm.nih.gov/gene/?term=64285 "C16orf8, Dist1, EGFR-RS, gene-89, gene-90, hDist1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018663 64285 RHBDF1 http://www.ncbi.nlm.nih.gov/gene/?term=64285 "C16orf8, Dist1, EGFR-RS, gene-89, gene-90, hDist1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018664 64288 ZSCAN31 http://www.ncbi.nlm.nih.gov/gene/?term=64288 "ZNF20-Lp, ZNF310P, ZNF323 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018665 64288 ZSCAN31 http://www.ncbi.nlm.nih.gov/gene/?term=64288 "ZNF20-Lp, ZNF310P, ZNF323 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018666 64288 ZSCAN31 http://www.ncbi.nlm.nih.gov/gene/?term=64288 "ZNF20-Lp, ZNF310P, ZNF323 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018667 6428 SRSF3 http://www.ncbi.nlm.nih.gov/gene/?term=6428 "SFRS3, SRp20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018668 64291 Osbpl1a http://www.ncbi.nlm.nih.gov/gene/?term=64291 "G430090F17Rik, Gm753, ORP-1, Osbpl1b " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018669 642946 FLVCR1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=642946 "LQK1, NCRNA00292 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018670 642968 FAM163B http://www.ncbi.nlm.nih.gov/gene/?term=642968 C9orf166 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018671 642987 TMEM232 http://www.ncbi.nlm.nih.gov/gene/?term=642987 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018672 6429 SRSF4 http://www.ncbi.nlm.nih.gov/gene/?term=6429 "SFRS4, SRP75 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018673 6429 SRSF4 http://www.ncbi.nlm.nih.gov/gene/?term=6429 "SFRS4, SRP75 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018674 642 BLMH http://www.ncbi.nlm.nih.gov/gene/?term=642 "BH, BMH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018675 642 BLMH http://www.ncbi.nlm.nih.gov/gene/?term=642 "BH, BMH " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018676 642 BLMH http://www.ncbi.nlm.nih.gov/gene/?term=642 "BH, BMH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018677 64307 Rpl24 http://www.ncbi.nlm.nih.gov/gene/?term=64307 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00018678 6430 SRSF5 http://www.ncbi.nlm.nih.gov/gene/?term=6430 "HRS, SFRS5, SRP40 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018679 6430 SRSF5 http://www.ncbi.nlm.nih.gov/gene/?term=6430 "HRS, SFRS5, SRP40 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018680 643155 SMIM15 http://www.ncbi.nlm.nih.gov/gene/?term=643155 C5orf43 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018681 64318 NOC3L http://www.ncbi.nlm.nih.gov/gene/?term=64318 "AD24, C10orf117, FAD24 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018682 6431 SRSF6 http://www.ncbi.nlm.nih.gov/gene/?term=6431 "B52, HEL-S-91, SFRS6, SRP55 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018683 6431 SRSF6 http://www.ncbi.nlm.nih.gov/gene/?term=6431 "B52, HEL-S-91, SFRS6, SRP55 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018684 643201 LOC643201 http://www.ncbi.nlm.nih.gov/gene/?term=643201 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018685 64320 RNF25 http://www.ncbi.nlm.nih.gov/gene/?term=64320 AO7 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018686 64320 RNF25 http://www.ncbi.nlm.nih.gov/gene/?term=64320 AO7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018687 64321 SOX17 http://www.ncbi.nlm.nih.gov/gene/?term=64321 VUR3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018688 643246 MAP1LC3B2 http://www.ncbi.nlm.nih.gov/gene/?term=643246 ATG8G mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018689 64324 NSD1 http://www.ncbi.nlm.nih.gov/gene/?term=64324 "ARA267, KMT3B, SOTOS, SOTOS1, STO " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018690 64324 NSD1 http://www.ncbi.nlm.nih.gov/gene/?term=64324 "ARA267, KMT3B, SOTOS, SOTOS1, STO " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018691 643253 CCT6P1 http://www.ncbi.nlm.nih.gov/gene/?term=643253 "CCT6-5P, CCT6AP1 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018692 64326 RFWD2 http://www.ncbi.nlm.nih.gov/gene/?term=64326 "COP1, RNF200 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018693 64326 RFWD2 http://www.ncbi.nlm.nih.gov/gene/?term=64326 "COP1, RNF200 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018694 64326 RFWD2 http://www.ncbi.nlm.nih.gov/gene/?term=64326 "COP1, RNF200 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018695 64327 LMBR1 http://www.ncbi.nlm.nih.gov/gene/?term=64327 "ACHP, C7orf2, DIF14, LSS, PPD2, THYP, TPT, ZRS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018696 64328 XPO4 http://www.ncbi.nlm.nih.gov/gene/?term=64328 exp4 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018697 64328 XPO4 http://www.ncbi.nlm.nih.gov/gene/?term=64328 exp4 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018698 64328 XPO4 http://www.ncbi.nlm.nih.gov/gene/?term=64328 exp4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018699 6432 SRSF7 http://www.ncbi.nlm.nih.gov/gene/?term=6432 "9G8, AAG3, SFRS7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018700 6432 SRSF7 http://www.ncbi.nlm.nih.gov/gene/?term=6432 "9G8, AAG3, SFRS7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018701 643314 KIAA0754 http://www.ncbi.nlm.nih.gov/gene/?term=643314 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018702 643314 KIAA0754 http://www.ncbi.nlm.nih.gov/gene/?term=643314 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018703 64332 NFKBIZ http://www.ncbi.nlm.nih.gov/gene/?term=64332 "IKBZ, INAP, MAIL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018704 64339 Fndc4 http://www.ncbi.nlm.nih.gov/gene/?term=64339 "2810430J06Rik, 6330410H20Rik, AB030187, AI838506, AW487863, FRCP1, Fnmp1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018705 6433 SFSWAP http://www.ncbi.nlm.nih.gov/gene/?term=6433 "SFRS8, SWAP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018706 6433 SFSWAP http://www.ncbi.nlm.nih.gov/gene/?term=6433 "SFRS8, SWAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018707 64342 HS1BP3 http://www.ncbi.nlm.nih.gov/gene/?term=64342 "ETM2, HS1-BP3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018708 64343 AZI2 http://www.ncbi.nlm.nih.gov/gene/?term=64343 "AZ2, NAP1, TILP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018709 64343 AZI2 http://www.ncbi.nlm.nih.gov/gene/?term=64343 "AZ2, NAP1, TILP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018710 64344 HIF3A http://www.ncbi.nlm.nih.gov/gene/?term=64344 "HIF-3A, HIF3-alpha-1, IPAS, MOP7, PASD7, bHLHe17 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018711 64344 HIF3A http://www.ncbi.nlm.nih.gov/gene/?term=64344 "HIF-3A, HIF3-alpha-1, IPAS, MOP7, PASD7, bHLHe17 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018712 64347 Sncg http://www.ncbi.nlm.nih.gov/gene/?term=64347 mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00018713 64347 Sncg http://www.ncbi.nlm.nih.gov/gene/?term=64347 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00018714 6434 TRA2B http://www.ncbi.nlm.nih.gov/gene/?term=6434 "Htra2-beta, PPP1R156, SFRS10, SRFS10, TRA2-BETA, TRAN2B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018715 6434 TRA2B http://www.ncbi.nlm.nih.gov/gene/?term=6434 "Htra2-beta, PPP1R156, SFRS10, SRFS10, TRA2-BETA, TRAN2B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018716 64356 Nrgn http://www.ncbi.nlm.nih.gov/gene/?term=64356 "BICKS, RC3 " mRNA Rattus norvegicus 7773006 Dendrite Neuron In situ hybridization "Table 1. As of 1994, mRNAs that have been localized within dendrites by in situ hybridization. Data are collected from Table 1. " RLID00018717 64356 Nrgn http://www.ncbi.nlm.nih.gov/gene/?term=64356 "BICKS, RC3 " mRNA Rattus norvegicus 7877439 Dendrite Neuron In situ hybridization "In addition, stain was also found within the proximal portion of apical dendrites of specific cortical neurons, primarily those within layers 5 and 6 of neocortex(Fig. 2A). Labeling was found to extend as far as six cell widths into the apical dendrite (inset in Fig. 2A) suggesting that RC3 mRNA may be translocated into the dendrites of specific cortical neurons. " RLID00018718 64359 NXN http://www.ncbi.nlm.nih.gov/gene/?term=64359 "NRX, TRG-4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018719 64359 NXN http://www.ncbi.nlm.nih.gov/gene/?term=64359 "NRX, TRG-4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018720 64359 NXN http://www.ncbi.nlm.nih.gov/gene/?term=64359 "NRX, TRG-4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018721 643749 TRAF3IP2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=643749 "C6UAS, C6orf3, NCRNA00248, TRAF3IP2-AS2 " lncRNA Homo sapiens 26222413 Nucleus Neuron In situ hybridization|qRT-PCR "In contrast to LINC00162, TRAF3IP2-AS1 transcript showed a surprisingly strong nuclear localization in DA cells (Fig. 2g and h). " RLID00018722 643749 TRAF3IP2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=643749 "C6UAS, C6orf3, NCRNA00248, TRAF3IP2-AS2 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018723 64374 SIL1 http://www.ncbi.nlm.nih.gov/gene/?term=64374 "BAP, MSS, ULG5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018724 64375 IKZF4 http://www.ncbi.nlm.nih.gov/gene/?term=64375 "EOS, ZNFN1A4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018725 64376 IKZF5 http://www.ncbi.nlm.nih.gov/gene/?term=64376 "PEGASUS, ZNFN1A5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018726 643834 PGA3 http://www.ncbi.nlm.nih.gov/gene/?term=643834 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018727 643836 ZFP62 http://www.ncbi.nlm.nih.gov/gene/?term=643836 "ZET, ZNF755 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018728 643836 ZFP62 http://www.ncbi.nlm.nih.gov/gene/?term=643836 "ZET, ZNF755 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018729 64383 Sirt2 http://www.ncbi.nlm.nih.gov/gene/?term=64383 "5730427M03Rik, SIR2L2, Sir2l " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018730 643866 CBLN3 http://www.ncbi.nlm.nih.gov/gene/?term=643866 PRO1486 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018731 64393 ZMAT3 http://www.ncbi.nlm.nih.gov/gene/?term=64393 "PAG608, WIG-1, WIG1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018732 64395 GMCL1 http://www.ncbi.nlm.nih.gov/gene/?term=64395 "BTBD13, GCL, GCL1, SPATA29 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018733 64397 ZNF106 http://www.ncbi.nlm.nih.gov/gene/?term=64397 "SH3BP3, ZFP106, ZNF474 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018734 643988 C1orf233 http://www.ncbi.nlm.nih.gov/gene/?term=643988 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018735 64398 MPP5 http://www.ncbi.nlm.nih.gov/gene/?term=64398 PALS1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018736 64398 MPP5 http://www.ncbi.nlm.nih.gov/gene/?term=64398 PALS1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018737 64400 AKTIP http://www.ncbi.nlm.nih.gov/gene/?term=64400 "FT1, FTS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018738 64400 AKTIP http://www.ncbi.nlm.nih.gov/gene/?term=64400 "FT1, FTS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018739 644019 CBWD6 http://www.ncbi.nlm.nih.gov/gene/?term=644019 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018740 64403 CDH24 http://www.ncbi.nlm.nih.gov/gene/?term=64403 CDH11L mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018741 644096 SDHAF1 http://www.ncbi.nlm.nih.gov/gene/?term=644096 LYRM8 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018742 6440 SFTPC http://www.ncbi.nlm.nih.gov/gene/?term=6440 "BRICD6, PSP-C, SFTP2, SMDP2, SP-C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018743 64411 ARAP3 http://www.ncbi.nlm.nih.gov/gene/?term=64411 "CENTD3, DRAG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018744 64412 GZF1 http://www.ncbi.nlm.nih.gov/gene/?term=64412 "ZBTB23, ZNF336 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018745 64418 TMEM168 http://www.ncbi.nlm.nih.gov/gene/?term=64418 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018746 64419 MTMR14 http://www.ncbi.nlm.nih.gov/gene/?term=64419 C3orf29 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018747 6441 SFTPD http://www.ncbi.nlm.nih.gov/gene/?term=6441 "COLEC7, PSP-D, SFTP4, SP-D " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018748 64420 SUSD1 http://www.ncbi.nlm.nih.gov/gene/?term=64420 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018749 64422 ATG3 http://www.ncbi.nlm.nih.gov/gene/?term=64422 "APG3, APG3-LIKE, APG3L, PC3-96 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018750 64422 ATG3 http://www.ncbi.nlm.nih.gov/gene/?term=64422 "APG3, APG3-LIKE, APG3L, PC3-96 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018751 64422 ATG3 http://www.ncbi.nlm.nih.gov/gene/?term=64422 "APG3, APG3-LIKE, APG3L, PC3-96 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018752 64423 INF2 http://www.ncbi.nlm.nih.gov/gene/?term=64423 "C14orf151, C14orf173, CMTDIE, FSGS5, pp9484 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018753 64425 POLR1E http://www.ncbi.nlm.nih.gov/gene/?term=64425 "PAF53, PRAF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018754 64425 POLR1E http://www.ncbi.nlm.nih.gov/gene/?term=64425 "PAF53, PRAF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018755 64426 SUDS3 http://www.ncbi.nlm.nih.gov/gene/?term=64426 "SAP45, SDS3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018756 64427 TTC31 http://www.ncbi.nlm.nih.gov/gene/?term=64427 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018757 64428 NARFL http://www.ncbi.nlm.nih.gov/gene/?term=64428 "HPRN, IOP1, LET1L, PRN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018758 6442 SGCA http://www.ncbi.nlm.nih.gov/gene/?term=6442 "50-DAG, A2, ADL, DAG2, DMDA2, LGMD2D, SCARMD1, adhalin " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018759 64430 PCNX4 http://www.ncbi.nlm.nih.gov/gene/?term=64430 "C14orf135, FBP2, PCNXL4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018760 64431 ACTR6 http://www.ncbi.nlm.nih.gov/gene/?term=64431 "ARP6, CDA12, HSPC281, MSTP136, hARP6, hARPX " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018761 64431 ACTR6 http://www.ncbi.nlm.nih.gov/gene/?term=64431 "ARP6, CDA12, HSPC281, MSTP136, hARP6, hARPX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018762 64432 MRPS25 http://www.ncbi.nlm.nih.gov/gene/?term=64432 "MRP-S25, RPMS25 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018763 64432 MRPS25 http://www.ncbi.nlm.nih.gov/gene/?term=64432 "MRP-S25, RPMS25 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018764 64434 NOM1 http://www.ncbi.nlm.nih.gov/gene/?term=64434 "C7orf3, PPP1R113, SGD1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018765 64434 NOM1 http://www.ncbi.nlm.nih.gov/gene/?term=64434 "C7orf3, PPP1R113, SGD1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018766 6443 SGCB http://www.ncbi.nlm.nih.gov/gene/?term=6443 "A3b, LGMD2E, SGC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018767 6443 SGCB http://www.ncbi.nlm.nih.gov/gene/?term=6443 "A3b, LGMD2E, SGC " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018768 6443 SGCB http://www.ncbi.nlm.nih.gov/gene/?term=6443 "A3b, LGMD2E, SGC " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018769 6443 SGCB http://www.ncbi.nlm.nih.gov/gene/?term=6443 "A3b, LGMD2E, SGC " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018770 6443 SGCB http://www.ncbi.nlm.nih.gov/gene/?term=6443 "A3b, LGMD2E, SGC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018771 64450 Gpr85 http://www.ncbi.nlm.nih.gov/gene/?term=64450 2900026B03Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018772 644591 PPIAL4G http://www.ncbi.nlm.nih.gov/gene/?term=644591 COAS-2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018773 6446 SGK1 http://www.ncbi.nlm.nih.gov/gene/?term=6446 SGK mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018774 6446 SGK1 http://www.ncbi.nlm.nih.gov/gene/?term=6446 SGK mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018775 644714 LIMD1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=644714 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018776 64478 CSMD1 http://www.ncbi.nlm.nih.gov/gene/?term=64478 PPP1R24 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018777 644844 PHGR1 http://www.ncbi.nlm.nih.gov/gene/?term=644844 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018778 644873 LINC01184 http://www.ncbi.nlm.nih.gov/gene/?term=644873 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018779 644961 ACTG1P20 http://www.ncbi.nlm.nih.gov/gene/?term=644961 lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00018780 644 BLVRA http://www.ncbi.nlm.nih.gov/gene/?term=644 "BLVR, BVR, BVRA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018781 644 BLVRA http://www.ncbi.nlm.nih.gov/gene/?term=644 "BLVR, BVR, BVRA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018782 645073 GAGE12G http://www.ncbi.nlm.nih.gov/gene/?term=645073 "AL4, CT4.7, GAGE-12G " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018783 6450 SH3BGR http://www.ncbi.nlm.nih.gov/gene/?term=6450 21-GARP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018784 6451 SH3BGRL http://www.ncbi.nlm.nih.gov/gene/?term=6451 "HEL-S-115, SH3BGR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018785 645249 MNX1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=645249 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018786 645296 RPL17P39 http://www.ncbi.nlm.nih.gov/gene/?term=645296 "RPL17_14_1450, hCG2004593 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018787 645296 RPL17P39 http://www.ncbi.nlm.nih.gov/gene/?term=645296 "RPL17_14_1450, hCG2004593 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018788 64529 Ctsb http://www.ncbi.nlm.nih.gov/gene/?term=64529 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00018789 6452 SH3BP2 http://www.ncbi.nlm.nih.gov/gene/?term=6452 "3BP-2, 3BP2, CRBM, CRPM, RES4-23 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018790 6452 SH3BP2 http://www.ncbi.nlm.nih.gov/gene/?term=6452 "3BP-2, 3BP2, CRBM, CRPM, RES4-23 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018791 6452 SH3BP2 http://www.ncbi.nlm.nih.gov/gene/?term=6452 "3BP-2, 3BP2, CRBM, CRPM, RES4-23 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018792 645441 RPL17P6 http://www.ncbi.nlm.nih.gov/gene/?term=645441 RPL17_1_64 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018793 645441 RPL17P6 http://www.ncbi.nlm.nih.gov/gene/?term=645441 RPL17_1_64 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018794 645553 LOC645553 http://www.ncbi.nlm.nih.gov/gene/?term=645553 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018795 6455 SH3GL1 http://www.ncbi.nlm.nih.gov/gene/?term=6455 "CNSA1, EEN, SH3D2B, SH3P8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018796 6455 SH3GL1 http://www.ncbi.nlm.nih.gov/gene/?term=6455 "CNSA1, EEN, SH3D2B, SH3P8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018797 6455 SH3GL1 http://www.ncbi.nlm.nih.gov/gene/?term=6455 "CNSA1, EEN, SH3D2B, SH3P8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018798 64577 ALDH8A1 http://www.ncbi.nlm.nih.gov/gene/?term=64577 "ALDH12, DJ352A20.2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018799 6457 SH3GL3 http://www.ncbi.nlm.nih.gov/gene/?term=6457 "CNSA3, EEN-B2, HsT19371, SH3D2C, SH3P13 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018800 6457 SH3GL3 http://www.ncbi.nlm.nih.gov/gene/?term=6457 "CNSA3, EEN-B2, HsT19371, SH3D2C, SH3P13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018801 64581 CLEC7A http://www.ncbi.nlm.nih.gov/gene/?term=64581 "BGR, CANDF4, CD369, CLECSF12, DECTIN1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018802 64581 CLEC7A http://www.ncbi.nlm.nih.gov/gene/?term=64581 "BGR, CANDF4, CD369, CLECSF12, DECTIN1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018803 64593 RBMY3AP http://www.ncbi.nlm.nih.gov/gene/?term=64593 "RBMY3P, RBMY4P, SPATA14 " lncRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00018804 64598 MOSPD3 http://www.ncbi.nlm.nih.gov/gene/?term=64598 "CDS3, NET30 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018805 64599 GIGYF1 http://www.ncbi.nlm.nih.gov/gene/?term=64599 "GYF1, PERQ1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018806 645 BLVRB http://www.ncbi.nlm.nih.gov/gene/?term=645 "BVRB, FLR, HEL-S-10, SDR43U1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018807 645 BLVRB http://www.ncbi.nlm.nih.gov/gene/?term=645 "BVRB, FLR, HEL-S-10, SDR43U1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018808 645 BLVRB http://www.ncbi.nlm.nih.gov/gene/?term=645 "BVRB, FLR, HEL-S-10, SDR43U1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018809 64602 Ireb2 http://www.ncbi.nlm.nih.gov/gene/?term=64602 "D9Ertd85e, Irp2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018810 6461 SHB http://www.ncbi.nlm.nih.gov/gene/?term=6461 bA3J10.2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018811 6461 SHB http://www.ncbi.nlm.nih.gov/gene/?term=6461 bA3J10.2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018812 646450 ARIH2OS http://www.ncbi.nlm.nih.gov/gene/?term=646450 C3orf71 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018813 646450 ARIH2OS http://www.ncbi.nlm.nih.gov/gene/?term=646450 C3orf71 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018814 64645 MFSD14A http://www.ncbi.nlm.nih.gov/gene/?term=64645 HIAT1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018815 6464 SHC1 http://www.ncbi.nlm.nih.gov/gene/?term=6464 "SHC, SHCA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018816 6464 SHC1 http://www.ncbi.nlm.nih.gov/gene/?term=6464 "SHC, SHCA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018817 64654 Fgf23 http://www.ncbi.nlm.nih.gov/gene/?term=64654 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00018818 64654 Fgf23 http://www.ncbi.nlm.nih.gov/gene/?term=64654 mRNA Mus musculus 16012775 Dendrite - Next generation sequencing "Because mouse Fgf23 mRNA was expressed in dendritic cells and activated spleen, tumor infiltrating dendritic cells are candidate sources of FGF23 secretion in TIO patients. " RLID00018819 64655 Mrps22 http://www.ncbi.nlm.nih.gov/gene/?term=64655 "3100002P07Rik, Rpms22 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018820 64656 Mrps23 http://www.ncbi.nlm.nih.gov/gene/?term=64656 "D11Bwg1153e, MRP-S23, Rpms23, S23mt " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018821 646588 LOC646588 http://www.ncbi.nlm.nih.gov/gene/?term=646588 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018822 64682 ANAPC1 http://www.ncbi.nlm.nih.gov/gene/?term=64682 "APC1, MCPR, TSG24 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018823 64682 ANAPC1 http://www.ncbi.nlm.nih.gov/gene/?term=64682 "APC1, MCPR, TSG24 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018824 64689 GORASP1 http://www.ncbi.nlm.nih.gov/gene/?term=64689 "GOLPH5, GRASP65, P65 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018825 64689 GORASP1 http://www.ncbi.nlm.nih.gov/gene/?term=64689 "GOLPH5, GRASP65, P65 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018826 646962 HRCT1 http://www.ncbi.nlm.nih.gov/gene/?term=646962 "LGLL338, PRO537, UNQ338 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018827 64697 Keg1 http://www.ncbi.nlm.nih.gov/gene/?term=64697 "0610008P16Rik, AI316519, GS4059 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018828 64697 Keg1 http://www.ncbi.nlm.nih.gov/gene/?term=64697 "0610008P16Rik, AI316519, GS4059 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00018829 64699 TMPRSS3 http://www.ncbi.nlm.nih.gov/gene/?term=64699 "DFNB10, DFNB8, ECHOS1, TADG12 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018830 64699 TMPRSS3 http://www.ncbi.nlm.nih.gov/gene/?term=64699 "DFNB10, DFNB8, ECHOS1, TADG12 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018831 6469 SHH http://www.ncbi.nlm.nih.gov/gene/?term=6469 "HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018832 646 BNC1 http://www.ncbi.nlm.nih.gov/gene/?term=646 "BNC, BSN1, HsT19447 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018833 647087 C7orf73 http://www.ncbi.nlm.nih.gov/gene/?term=647087 PL-5283 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018834 647087 C7orf73 http://www.ncbi.nlm.nih.gov/gene/?term=647087 PL-5283 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018835 647087 C7orf73 http://www.ncbi.nlm.nih.gov/gene/?term=647087 PL-5283 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018836 647087 C7orf73 http://www.ncbi.nlm.nih.gov/gene/?term=647087 PL-5283 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018837 64708 COPS7B http://www.ncbi.nlm.nih.gov/gene/?term=64708 "CSN7B, SGN7b " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018838 64708 COPS7B http://www.ncbi.nlm.nih.gov/gene/?term=64708 "CSN7B, SGN7b " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018839 6470 SHMT1 http://www.ncbi.nlm.nih.gov/gene/?term=6470 "CSHMT, SHMT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018840 6470 SHMT1 http://www.ncbi.nlm.nih.gov/gene/?term=6470 "CSHMT, SHMT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018841 6470 SHMT1 http://www.ncbi.nlm.nih.gov/gene/?term=6470 "CSHMT, SHMT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018842 64710 NUCKS1 http://www.ncbi.nlm.nih.gov/gene/?term=64710 "JC7, NUCKS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018843 64710 NUCKS1 http://www.ncbi.nlm.nih.gov/gene/?term=64710 "JC7, NUCKS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018844 64717 TRG-CCC2-2 http://www.ncbi.nlm.nih.gov/gene/?term=64717 "TRG-CCC2-1, TRG4, TRNAG4 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00018845 6472 SHMT2 http://www.ncbi.nlm.nih.gov/gene/?term=6472 "GLYA, HEL-S-51e, SHMT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018846 6473 SHOX http://www.ncbi.nlm.nih.gov/gene/?term=6473 "GCFX, PHOGY, SS, SHOX " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018847 6473 SHOX http://www.ncbi.nlm.nih.gov/gene/?term=6473 "GCFX, PHOGY, SS, SHOX " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018848 64743 WDR13 http://www.ncbi.nlm.nih.gov/gene/?term=64743 MG21 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018849 64743 WDR13 http://www.ncbi.nlm.nih.gov/gene/?term=64743 MG21 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018850 64744 SMAP2 http://www.ncbi.nlm.nih.gov/gene/?term=64744 SMAP1L mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018851 64745 METTL17 http://www.ncbi.nlm.nih.gov/gene/?term=64745 METT11D1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018852 64746 ACBD3 http://www.ncbi.nlm.nih.gov/gene/?term=64746 "GCP60, GOCAP1, GOLPH1, PAP7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018853 64747 MFSD1 http://www.ncbi.nlm.nih.gov/gene/?term=64747 SMAP4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018854 64747 MFSD1 http://www.ncbi.nlm.nih.gov/gene/?term=64747 SMAP4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018855 6474 SHOX2 http://www.ncbi.nlm.nih.gov/gene/?term=6474 "OG12, OG12X, SHOT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018856 64750 SMURF2 http://www.ncbi.nlm.nih.gov/gene/?term=64750 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018857 64750 SMURF2 http://www.ncbi.nlm.nih.gov/gene/?term=64750 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018858 64755 C16orf58 http://www.ncbi.nlm.nih.gov/gene/?term=64755 RUS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018859 64756 ATPAF1 http://www.ncbi.nlm.nih.gov/gene/?term=64756 "ATP11, ATP11p " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018860 64756 ATPAF1 http://www.ncbi.nlm.nih.gov/gene/?term=64756 "ATP11, ATP11p " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018861 64756 ATPAF1 http://www.ncbi.nlm.nih.gov/gene/?term=64756 "ATP11, ATP11p " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018862 64756 ATPAF1 http://www.ncbi.nlm.nih.gov/gene/?term=64756 "ATP11, ATP11p " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018863 64757 MARC1 http://www.ncbi.nlm.nih.gov/gene/?term=64757 MOSC1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018864 64759 TNS3 http://www.ncbi.nlm.nih.gov/gene/?term=64759 "TEM6, TENS1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018865 64761 PARP12 http://www.ncbi.nlm.nih.gov/gene/?term=64761 "ARTD12, MST109, MSTP109, ZC3H1, ZC3HDC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018866 64761 PARP12 http://www.ncbi.nlm.nih.gov/gene/?term=64761 "ARTD12, MST109, MSTP109, ZC3H1, ZC3HDC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018867 64762 GAREM1 http://www.ncbi.nlm.nih.gov/gene/?term=64762 "C18orf11, FAM59A, GAREM, Gm944 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018868 64763 ZNF574 http://www.ncbi.nlm.nih.gov/gene/?term=64763 FP972 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018869 64764 CREB3L2 http://www.ncbi.nlm.nih.gov/gene/?term=64764 BBF2H7 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018870 64768 IPPK http://www.ncbi.nlm.nih.gov/gene/?term=64768 "C9orf12, INSP5K2, IP5K, IPK1, bA476B13.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018871 64768 IPPK http://www.ncbi.nlm.nih.gov/gene/?term=64768 "C9orf12, INSP5K2, IP5K, IPK1, bA476B13.1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018872 64768 IPPK http://www.ncbi.nlm.nih.gov/gene/?term=64768 "C9orf12, INSP5K2, IP5K, IPK1, bA476B13.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018873 64769 MEAF6 http://www.ncbi.nlm.nih.gov/gene/?term=64769 "C1orf149, CENP-28, EAF6, NY-SAR-91 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018874 64769 MEAF6 http://www.ncbi.nlm.nih.gov/gene/?term=64769 "C1orf149, CENP-28, EAF6, NY-SAR-91 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018875 64770 CCDC14 http://www.ncbi.nlm.nih.gov/gene/?term=64770 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018876 64773 PCED1A http://www.ncbi.nlm.nih.gov/gene/?term=64773 "C20orf81, FAM113A, bA12M19.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018877 64776 C11orf1 http://www.ncbi.nlm.nih.gov/gene/?term=64776 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018878 64777 RMND5B http://www.ncbi.nlm.nih.gov/gene/?term=64777 "GID2, GID2B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018879 64778 FNDC3B http://www.ncbi.nlm.nih.gov/gene/?term=64778 "FAD104, PRO4979, YVTM2421 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018880 64778 FNDC3B http://www.ncbi.nlm.nih.gov/gene/?term=64778 "FAD104, PRO4979, YVTM2421 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018881 64780 MICAL1 http://www.ncbi.nlm.nih.gov/gene/?term=64780 "MICAL, MICAL-1, NICAL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018882 64782 AEN http://www.ncbi.nlm.nih.gov/gene/?term=64782 "ISG20L1, pp12744 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018883 64783 RBM15 http://www.ncbi.nlm.nih.gov/gene/?term=64783 "OTT, OTT1, SPEN " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018884 64784 CRTC3 http://www.ncbi.nlm.nih.gov/gene/?term=64784 "TORC-3, TORC3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018885 64785 GINS3 http://www.ncbi.nlm.nih.gov/gene/?term=64785 PSF3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018886 64785 GINS3 http://www.ncbi.nlm.nih.gov/gene/?term=64785 PSF3 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018887 64785 GINS3 http://www.ncbi.nlm.nih.gov/gene/?term=64785 PSF3 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018888 64785 GINS3 http://www.ncbi.nlm.nih.gov/gene/?term=64785 PSF3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018889 64786 TBC1D15 http://www.ncbi.nlm.nih.gov/gene/?term=64786 RAB7-GAP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018890 64787 EPS8L2 http://www.ncbi.nlm.nih.gov/gene/?term=64787 EPS8R2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018891 6478 SIAH2 http://www.ncbi.nlm.nih.gov/gene/?term=6478 hSiah2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018892 6478 SIAH2 http://www.ncbi.nlm.nih.gov/gene/?term=6478 hSiah2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018893 64792 IFT22 http://www.ncbi.nlm.nih.gov/gene/?term=64792 RABL5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018894 64793 CEP85 http://www.ncbi.nlm.nih.gov/gene/?term=64793 CCDC21 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018895 64793 CEP85 http://www.ncbi.nlm.nih.gov/gene/?term=64793 CCDC21 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018896 64794 DDX31 http://www.ncbi.nlm.nih.gov/gene/?term=64794 PPP1R25 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018897 64795 RMND5A http://www.ncbi.nlm.nih.gov/gene/?term=64795 "CTLH, GID2, GID2A, RMD5, p44CTLH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018898 64795 RMND5A http://www.ncbi.nlm.nih.gov/gene/?term=64795 "CTLH, GID2, GID2A, RMD5, p44CTLH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018899 64801 ARV1 http://www.ncbi.nlm.nih.gov/gene/?term=64801 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018900 64802 NMNAT1 http://www.ncbi.nlm.nih.gov/gene/?term=64802 "LCA9, NMNAT, PNAT1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018901 64802 NMNAT1 http://www.ncbi.nlm.nih.gov/gene/?term=64802 "LCA9, NMNAT, PNAT1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018902 6480 ST6GAL1 http://www.ncbi.nlm.nih.gov/gene/?term=6480 "SIAT1, ST6GalI, ST6N " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018903 6480 ST6GAL1 http://www.ncbi.nlm.nih.gov/gene/?term=6480 "SIAT1, ST6GalI, ST6N " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018904 64817 Svep1 http://www.ncbi.nlm.nih.gov/gene/?term=64817 "1110021D17Rik, 4833413O10Rik, AA387071, D430029O09Rik, Polydom " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018905 64818 Krt81 http://www.ncbi.nlm.nih.gov/gene/?term=64818 "AA589625, Krt2-19 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00018906 6482 ST3GAL1 http://www.ncbi.nlm.nih.gov/gene/?term=6482 "Gal-NAc6S, SIAT4A, SIATFL, ST3GalA, ST3GalA.1, ST3GalIA, ST3GalIA, 1, ST3O " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018907 64834 ELOVL1 http://www.ncbi.nlm.nih.gov/gene/?term=64834 "CGI-88, Ssc1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018908 64837 KLC2 http://www.ncbi.nlm.nih.gov/gene/?term=64837 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018909 64839 FBXL17 http://www.ncbi.nlm.nih.gov/gene/?term=64839 "FBXO13, Fbl17, Fbx13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018910 64839 FBXL17 http://www.ncbi.nlm.nih.gov/gene/?term=64839 "FBXO13, Fbl17, Fbx13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018911 6483 ST3GAL2 http://www.ncbi.nlm.nih.gov/gene/?term=6483 "Gal-NAc6S, SIAT4B, ST3GALII, ST3GalA.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018912 64841 GNPNAT1 http://www.ncbi.nlm.nih.gov/gene/?term=64841 "GNA1, GNPNAT, Gpnat1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018913 64843 ISL2 http://www.ncbi.nlm.nih.gov/gene/?term=64843 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018914 64844 MARCH7 http://www.ncbi.nlm.nih.gov/gene/?term=64844 "AXO, AXOT, MARCH-VII, RNF177 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018915 64848 YTHDC2 http://www.ncbi.nlm.nih.gov/gene/?term=64848 CAHL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018916 64849 SLC13A3 http://www.ncbi.nlm.nih.gov/gene/?term=64849 "NADC3, SDCT2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018917 6484 ST3GAL4 http://www.ncbi.nlm.nih.gov/gene/?term=6484 "CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST3GalIV, STZ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018918 6484 ST3GAL4 http://www.ncbi.nlm.nih.gov/gene/?term=6484 "CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST3GalIV, STZ " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018919 64852 TUT1 http://www.ncbi.nlm.nih.gov/gene/?term=64852 "PAPD2, RBM21, STARPAP, TUTase, URLC6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018920 64853 AIDA http://www.ncbi.nlm.nih.gov/gene/?term=64853 C1orf80 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018921 64853 AIDA http://www.ncbi.nlm.nih.gov/gene/?term=64853 C1orf80 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018922 64854 USP46 http://www.ncbi.nlm.nih.gov/gene/?term=64854 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018923 64854 USP46 http://www.ncbi.nlm.nih.gov/gene/?term=64854 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018924 64854 USP46 http://www.ncbi.nlm.nih.gov/gene/?term=64854 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018925 64855 FAM129B http://www.ncbi.nlm.nih.gov/gene/?term=64855 "C9orf88, MEG-3, MINERVA, OC58, bA356B19.6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018926 64856 VWA1 http://www.ncbi.nlm.nih.gov/gene/?term=64856 WARP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018927 64857 PLEKHG2 http://www.ncbi.nlm.nih.gov/gene/?term=64857 "ARHGEF42, CLG, LDAMD " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018928 64857 PLEKHG2 http://www.ncbi.nlm.nih.gov/gene/?term=64857 "ARHGEF42, CLG, LDAMD " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018929 64863 METTL4 http://www.ncbi.nlm.nih.gov/gene/?term=64863 HsT661 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018930 64866 CDCP1 http://www.ncbi.nlm.nih.gov/gene/?term=64866 "CD318, SIMA135, TRASK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018931 64866 CDCP1 http://www.ncbi.nlm.nih.gov/gene/?term=64866 "CD318, SIMA135, TRASK " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018932 64866 CDCP1 http://www.ncbi.nlm.nih.gov/gene/?term=64866 "CD318, SIMA135, TRASK " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018933 6487 ST3GAL3 http://www.ncbi.nlm.nih.gov/gene/?term=6487 "EIEE15, MRT12, SIAT6, ST3GALII, ST3GalIII, ST3N " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018934 64897 C12orf43 http://www.ncbi.nlm.nih.gov/gene/?term=64897 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018935 648 BMI1 http://www.ncbi.nlm.nih.gov/gene/?term=648 "FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018936 648 BMI1 http://www.ncbi.nlm.nih.gov/gene/?term=648 "FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018937 64900 LPIN3 http://www.ncbi.nlm.nih.gov/gene/?term=64900 "LIPN3L, SMP2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018938 64900 LPIN3 http://www.ncbi.nlm.nih.gov/gene/?term=64900 "LIPN3L, SMP2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018939 64900 LPIN3 http://www.ncbi.nlm.nih.gov/gene/?term=64900 "LIPN3L, SMP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018940 6490 PMEL http://www.ncbi.nlm.nih.gov/gene/?term=6490 "D12S53E, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV, gp100 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018941 6491 STIL http://www.ncbi.nlm.nih.gov/gene/?term=6491 "MCPH7, SIL " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018942 6491 STIL http://www.ncbi.nlm.nih.gov/gene/?term=6491 "MCPH7, SIL " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018943 6491 STIL http://www.ncbi.nlm.nih.gov/gene/?term=6491 "MCPH7, SIL " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018944 64921 CASD1 http://www.ncbi.nlm.nih.gov/gene/?term=64921 "C7orf12, NBLA04196 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018945 64924 SLC30A5 http://www.ncbi.nlm.nih.gov/gene/?term=64924 "ZNT5, ZNTL1, ZTL1, ZnT-5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018946 64924 SLC30A5 http://www.ncbi.nlm.nih.gov/gene/?term=64924 "ZNT5, ZNTL1, ZTL1, ZnT-5 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018947 64924 SLC30A5 http://www.ncbi.nlm.nih.gov/gene/?term=64924 "ZNT5, ZNTL1, ZTL1, ZnT-5 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018948 64924 SLC30A5 http://www.ncbi.nlm.nih.gov/gene/?term=64924 "ZNT5, ZNTL1, ZTL1, ZnT-5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018949 64927 TTC23 http://www.ncbi.nlm.nih.gov/gene/?term=64927 HCC-8 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018950 64928 MRPL14 http://www.ncbi.nlm.nih.gov/gene/?term=64928 "L14mt, L32mt, MRP-L14, MRP-L32, MRPL32, RMPL32, RPML32 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018951 64930 Tsc1 http://www.ncbi.nlm.nih.gov/gene/?term=64930 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018952 64943 NT5DC2 http://www.ncbi.nlm.nih.gov/gene/?term=64943 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018953 64945 Cldn12 http://www.ncbi.nlm.nih.gov/gene/?term=64945 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018954 64946 CENPH http://www.ncbi.nlm.nih.gov/gene/?term=64946 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018955 64946 CENPH http://www.ncbi.nlm.nih.gov/gene/?term=64946 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018956 64946 CENPH http://www.ncbi.nlm.nih.gov/gene/?term=64946 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00018957 64949 MRPS26 http://www.ncbi.nlm.nih.gov/gene/?term=64949 "C20orf193, GI008, MRP-S13, MRP-S26, MRPS13, NY-BR-87, RPMS13, dJ534B8.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018958 64949 MRPS26 http://www.ncbi.nlm.nih.gov/gene/?term=64949 "C20orf193, GI008, MRP-S13, MRP-S26, MRPS13, NY-BR-87, RPMS13, dJ534B8.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018959 6494 SIPA1 http://www.ncbi.nlm.nih.gov/gene/?term=6494 SPA1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018960 64951 MRPS24 http://www.ncbi.nlm.nih.gov/gene/?term=64951 "HSPC335, MRP-S24, S24mt, bMRP-47, bMRP47 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018961 64960 MRPS15 http://www.ncbi.nlm.nih.gov/gene/?term=64960 "DC37, MPR-S15, RPMS15, S15mt " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018962 64963 MRPS11 http://www.ncbi.nlm.nih.gov/gene/?term=64963 "HCC-2, MRP-S11, S11mt " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018963 64965 MRPS9 http://www.ncbi.nlm.nih.gov/gene/?term=64965 "MRP-S9, RPMS9, S9mt " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018964 64965 MRPS9 http://www.ncbi.nlm.nih.gov/gene/?term=64965 "MRP-S9, RPMS9, S9mt " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018965 64968 MRPS6 http://www.ncbi.nlm.nih.gov/gene/?term=64968 "C21orf101, MRP-S6, RPMS6, S6mt " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018966 64968 MRPS6 http://www.ncbi.nlm.nih.gov/gene/?term=64968 "C21orf101, MRP-S6, RPMS6, S6mt " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018967 64969 MRPS5 http://www.ncbi.nlm.nih.gov/gene/?term=64969 "MRP-S5, S5mt " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018968 64969 MRPS5 http://www.ncbi.nlm.nih.gov/gene/?term=64969 "MRP-S5, S5mt " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018969 64975 MRPL41 http://www.ncbi.nlm.nih.gov/gene/?term=64975 "BMRP, MRP-L27, MRPL27, PIG3, RPML27 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018970 64976 MRPL40 http://www.ncbi.nlm.nih.gov/gene/?term=64976 "L40mt, MRP-L22, MRP-L40, MRPL22, NLVCF, URIM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018971 64978 MRPL38 http://www.ncbi.nlm.nih.gov/gene/?term=64978 "HSPC262, L38MT, MRP-L3, MRP-L38, RPML3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018972 64979 MRPL36 http://www.ncbi.nlm.nih.gov/gene/?term=64979 "BRIP1, L36mt, MRP-L36, PRPL36, RPMJ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018973 64979 MRPL36 http://www.ncbi.nlm.nih.gov/gene/?term=64979 "BRIP1, L36mt, MRP-L36, PRPL36, RPMJ " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018974 6497 SKI http://www.ncbi.nlm.nih.gov/gene/?term=6497 "SGS, SKV " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018975 64981 MRPL34 http://www.ncbi.nlm.nih.gov/gene/?term=64981 L34mt mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018976 64983 MRPL32 http://www.ncbi.nlm.nih.gov/gene/?term=64983 "HSPC283, L32mt, MRP-L32, bMRP-59b " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018977 64983 MRPL32 http://www.ncbi.nlm.nih.gov/gene/?term=64983 "HSPC283, L32mt, MRP-L32, bMRP-59b " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018978 649 BMP1 http://www.ncbi.nlm.nih.gov/gene/?term=649 "OI13, PCOLC, PCP, PCP2, TLD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018979 65003 MRPL11 http://www.ncbi.nlm.nih.gov/gene/?term=65003 "CGI-113, L11MT, MRP-L11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018980 65005 MRPL9 http://www.ncbi.nlm.nih.gov/gene/?term=65005 L9mt mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018981 65008 MRPL1 http://www.ncbi.nlm.nih.gov/gene/?term=65008 "BM022, L1MT, MRP-L1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018982 65008 MRPL1 http://www.ncbi.nlm.nih.gov/gene/?term=65008 "BM022, L1MT, MRP-L1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018983 65009 NDRG4 http://www.ncbi.nlm.nih.gov/gene/?term=65009 "BDM1, SMAP-8, SMAP8 " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00018984 6500 SKP1 http://www.ncbi.nlm.nih.gov/gene/?term=6500 "EMC19, OCP-II, OCP2A, TCEB1L, p19A, SKP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018985 6500 SKP1 http://www.ncbi.nlm.nih.gov/gene/?term=6500 "EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018986 65010 SLC26A6 http://www.ncbi.nlm.nih.gov/gene/?term=65010 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018987 65010 SLC26A6 http://www.ncbi.nlm.nih.gov/gene/?term=65010 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018988 65018 PINK1 http://www.ncbi.nlm.nih.gov/gene/?term=65018 "BRPK, PARK6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018989 65018 PINK1 http://www.ncbi.nlm.nih.gov/gene/?term=65018 "BRPK, PARK6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018990 65019 Rpl23 http://www.ncbi.nlm.nih.gov/gene/?term=65019 2810009A01Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00018991 65020 Zfp110 http://www.ncbi.nlm.nih.gov/gene/?term=65020 "2900024E01Rik, N28112, NRIF, Nrif1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00018992 6502 SKP2 http://www.ncbi.nlm.nih.gov/gene/?term=6502 "FBL1, FBXL1, FLB1, p45 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018993 65055 REEP1 http://www.ncbi.nlm.nih.gov/gene/?term=65055 "C2orf23, HMN5B, SPG31, Yip2a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018994 65056 GPBP1 http://www.ncbi.nlm.nih.gov/gene/?term=65056 "GPBP, SSH6, VASCULIN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018995 65056 GPBP1 http://www.ncbi.nlm.nih.gov/gene/?term=65056 "GPBP, SSH6, VASCULIN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00018996 65056 GPBP1 http://www.ncbi.nlm.nih.gov/gene/?term=65056 "GPBP, SSH6, VASCULIN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018997 65057 ACD http://www.ncbi.nlm.nih.gov/gene/?term=65057 "PIP1, PTOP, TINT1, TPP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00018998 65057 ACD http://www.ncbi.nlm.nih.gov/gene/?term=65057 "PIP1, PTOP, TINT1, TPP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00018999 65062 TMEM237 http://www.ncbi.nlm.nih.gov/gene/?term=65062 "ALS2CR4, JBTS14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019000 65062 TMEM237 http://www.ncbi.nlm.nih.gov/gene/?term=65062 "ALS2CR4, JBTS14 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019001 6506 SLC1A2 http://www.ncbi.nlm.nih.gov/gene/?term=6506 "EAAT2, GLT-1, HBGT " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019002 6506 SLC1A2 http://www.ncbi.nlm.nih.gov/gene/?term=6506 "EAAT2, GLT-1, HBGT " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019003 65078 RTN4R http://www.ncbi.nlm.nih.gov/gene/?term=65078 "NGR, NOGOR " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019004 65078 RTN4R http://www.ncbi.nlm.nih.gov/gene/?term=65078 "NGR, NOGOR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019005 6507 SLC1A3 http://www.ncbi.nlm.nih.gov/gene/?term=6507 "EA6, EAAT1, GLAST, GLAST1 " mRNA Homo sapiens 16042756 Endoplasmic reticulum HEK293 cell RT-PCR "When expressed in HEK293 cells, EAAT1ex9skip mRNA is translated into a truncated protein localized in the endoplasmic reticulum. " RLID00019006 65080 MRPL44 http://www.ncbi.nlm.nih.gov/gene/?term=65080 "COXPD16, L44MT, MRP-L44 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019007 65080 MRPL44 http://www.ncbi.nlm.nih.gov/gene/?term=65080 "COXPD16, L44MT, MRP-L44 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019008 65080 MRPL44 http://www.ncbi.nlm.nih.gov/gene/?term=65080 "COXPD16, L44MT, MRP-L44 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019009 65082 VPS33A http://www.ncbi.nlm.nih.gov/gene/?term=65082 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019010 65082 VPS33A http://www.ncbi.nlm.nih.gov/gene/?term=65082 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019011 65082 VPS33A http://www.ncbi.nlm.nih.gov/gene/?term=65082 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019012 65083 NOL6 http://www.ncbi.nlm.nih.gov/gene/?term=65083 "NRAP, UTP22, bA311H10.1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019013 65083 NOL6 http://www.ncbi.nlm.nih.gov/gene/?term=65083 "NRAP, UTP22, bA311H10.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019014 65084 TMEM135 http://www.ncbi.nlm.nih.gov/gene/?term=65084 PMP52 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019015 6508 SLC4A3 http://www.ncbi.nlm.nih.gov/gene/?term=6508 "AE3, SLC2C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019016 65094 JMJD4 http://www.ncbi.nlm.nih.gov/gene/?term=65094 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019017 65094 JMJD4 http://www.ncbi.nlm.nih.gov/gene/?term=65094 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019018 65098 Zfand6 http://www.ncbi.nlm.nih.gov/gene/?term=65098 "3110005P07Rik, Awp1, Za20d3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019019 65098 Zfand6 http://www.ncbi.nlm.nih.gov/gene/?term=65098 "3110005P07Rik, Awp1, Za20d3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019020 6509 SLC1A4 http://www.ncbi.nlm.nih.gov/gene/?term=6509 "ASCT1, SATT, SPATCCM " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019021 650 BMP2 http://www.ncbi.nlm.nih.gov/gene/?term=650 "BDA2A, BMP2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019022 650 BMP2 http://www.ncbi.nlm.nih.gov/gene/?term=650 "BDA2, BMP2A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019023 65103 Arl6ip6 http://www.ncbi.nlm.nih.gov/gene/?term=65103 "2310057C01Rik, 2610529A11Rik, Aip-6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019024 65108 MARCKSL1 http://www.ncbi.nlm.nih.gov/gene/?term=65108 "F52, MACMARCKS, MLP, MLP1, MRP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019025 6510 SLC1A5 http://www.ncbi.nlm.nih.gov/gene/?term=6510 "AAAT, ASCT2, ATBO, M7V1, M7VS1, R16, RDRC " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019026 6510 SLC1A5 http://www.ncbi.nlm.nih.gov/gene/?term=6510 "AAAT, ASCT2, ATBO, M7V1, M7VS1, R16, RDRC " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019027 6510 SLC1A5 http://www.ncbi.nlm.nih.gov/gene/?term=6510 "AAAT, ASCT2, ATBO, M7V1, M7VS1, R16, RDRC " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019028 65114 Vps35 http://www.ncbi.nlm.nih.gov/gene/?term=65114 "AI647796, Mem3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019029 65117 RSRC2 http://www.ncbi.nlm.nih.gov/gene/?term=65117 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019030 65124 SOWAHC http://www.ncbi.nlm.nih.gov/gene/?term=65124 "ANKRD57, C2orf26 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019031 65125 WNK1 http://www.ncbi.nlm.nih.gov/gene/?term=65125 "HSAN2, HSN2, KDP, PPP1R167, PRKWNK1, PSK, p65 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019032 65125 WNK1 http://www.ncbi.nlm.nih.gov/gene/?term=65125 "HSAN2, HSN2, KDP, PPP1R167, PRKWNK1, PSK, p65 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019033 65125 WNK1 http://www.ncbi.nlm.nih.gov/gene/?term=65125 "HSAN2, HSN2, KDP, PPP1R167, PRKWNK1, PSK, p65 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019034 6512 SLC1A7 http://www.ncbi.nlm.nih.gov/gene/?term=6512 "AAAT, EAAT5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019035 6513 SLC2A1 http://www.ncbi.nlm.nih.gov/gene/?term=6513 "CSE, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT-1, GLUT1, GLUT1DS, HTLVR, PED, SDCHCN " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019036 6513 SLC2A1 http://www.ncbi.nlm.nih.gov/gene/?term=6513 "CSE, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT-1, GLUT1, GLUT1DS, HTLVR, PED, SDCHCN " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019037 6515 SLC2A3 http://www.ncbi.nlm.nih.gov/gene/?term=6515 GLUT3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019038 651746 ANKRD33B http://www.ncbi.nlm.nih.gov/gene/?term=651746 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019039 6517 SLC2A4 http://www.ncbi.nlm.nih.gov/gene/?term=6517 GLUT4 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019040 6517 SLC2A4 http://www.ncbi.nlm.nih.gov/gene/?term=6517 GLUT4 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019041 65180 Kcnd2 http://www.ncbi.nlm.nih.gov/gene/?term=65180 "Kv4.2, RK5, Shal1 " mRNA Rattus norvegicus 21034530 Dendrite Hippocampus In situ hybridization "In this study, Kv4.2 mRNAs were shown to be localized in the dendrites near postsynaptic regions. " RLID00019042 6518 SLC2A5 http://www.ncbi.nlm.nih.gov/gene/?term=6518 "GLUT-5, GLUT5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019043 651 BMP3 http://www.ncbi.nlm.nih.gov/gene/?term=651 BMP-3A mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019044 651 BMP3 http://www.ncbi.nlm.nih.gov/gene/?term=651 BMP-3A mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019045 6520 SLC3A2 http://www.ncbi.nlm.nih.gov/gene/?term=6520 "4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019046 6520 SLC3A2 http://www.ncbi.nlm.nih.gov/gene/?term=6520 "4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019047 65220 NADK http://www.ncbi.nlm.nih.gov/gene/?term=65220 dJ283E3.1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019048 65220 NADK http://www.ncbi.nlm.nih.gov/gene/?term=65220 dJ283E3.1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019049 6522 SLC4A2 http://www.ncbi.nlm.nih.gov/gene/?term=6522 "AE2, BND3L, EPB3L1, HKB3, NBND3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019050 6522 SLC4A2 http://www.ncbi.nlm.nih.gov/gene/?term=6522 "AE2, BND3L, EPB3L1, HKB3, NBND3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019051 6523 SLC5A1 http://www.ncbi.nlm.nih.gov/gene/?term=6523 "D22S675, NAGT, SGLT1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019052 65243 ZFP69B http://www.ncbi.nlm.nih.gov/gene/?term=65243 "ZKSCAN23B, ZNF643, ZSCAN54B " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019053 65243 ZFP69B http://www.ncbi.nlm.nih.gov/gene/?term=65243 "ZKSCAN23B, ZNF643, ZSCAN54B " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019054 65246 Xpo7 http://www.ncbi.nlm.nih.gov/gene/?term=65246 "4930506C02Rik, BB164534, Ranbp16, mKIAA0745 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019055 65254 Dpysl5 http://www.ncbi.nlm.nih.gov/gene/?term=65254 "CRAM, CRMP-5, Crmp5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019056 65258 MPPE1 http://www.ncbi.nlm.nih.gov/gene/?term=65258 PGAP5 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019057 6525 SMTN http://www.ncbi.nlm.nih.gov/gene/?term=6525 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019058 65260 COA7 http://www.ncbi.nlm.nih.gov/gene/?term=65260 "C1orf163, RESA1, SELRC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019059 65263 PYCRL http://www.ncbi.nlm.nih.gov/gene/?term=65263 PYCR3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019060 65264 UBE2Z http://www.ncbi.nlm.nih.gov/gene/?term=65264 "HOYS7, USE1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019061 65264 UBE2Z http://www.ncbi.nlm.nih.gov/gene/?term=65264 "HOYS7, USE1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019062 65264 UBE2Z http://www.ncbi.nlm.nih.gov/gene/?term=65264 "HOYS7, USE1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019063 65265 C8orf33 http://www.ncbi.nlm.nih.gov/gene/?term=65265 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019064 65267 WNK3 http://www.ncbi.nlm.nih.gov/gene/?term=65267 PRKWNK3 mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00019065 65267 WNK3 http://www.ncbi.nlm.nih.gov/gene/?term=65267 PRKWNK3 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019066 65267 WNK3 http://www.ncbi.nlm.nih.gov/gene/?term=65267 PRKWNK3 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019067 65267 WNK3 http://www.ncbi.nlm.nih.gov/gene/?term=65267 PRKWNK3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019068 6526 SLC5A3 http://www.ncbi.nlm.nih.gov/gene/?term=6526 "BCW2, SMIT, SMIT1, SMIT2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019069 6528 SLC5A5 http://www.ncbi.nlm.nih.gov/gene/?term=6528 "NIS, TDH1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019070 6528 SLC5A5 http://www.ncbi.nlm.nih.gov/gene/?term=6528 "NIS, TDH1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019071 652965 SNORA48 http://www.ncbi.nlm.nih.gov/gene/?term=652965 "ACA48A, SNORA48 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00019072 652965 SNORA48 http://www.ncbi.nlm.nih.gov/gene/?term=652965 "ACA48A, SNORA48 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00019073 652966 SNORD10 http://www.ncbi.nlm.nih.gov/gene/?term=652966 mgU6-77 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019074 652995 UCA1 http://www.ncbi.nlm.nih.gov/gene/?term=652995 "CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 " lncRNA Homo sapiens 20117985 Cytoplasm Bladder cancer cell In situ hybridization|RT-PCR "UCA1 gene locates in the cytoplasm, and its mRNA expression level is closely correlated to the progression of bladder cancer, indication its potential as a specific molecular marker of bladder cancer. " RLID00019075 652995 UCA1 http://www.ncbi.nlm.nih.gov/gene/?term=652995 "CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 " lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019076 6529 SLC6A1 http://www.ncbi.nlm.nih.gov/gene/?term=6529 "GABATHG, GABATR, GAT1, MAE " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019077 652 BMP4 http://www.ncbi.nlm.nih.gov/gene/?term=652 "BMP2B, BMP2B1, MCOPS6, OFC11, ZYME " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019078 653121 ZBTB8A http://www.ncbi.nlm.nih.gov/gene/?term=653121 "BOZF1, ZBTB8, ZNF916A " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019079 653121 ZBTB8A http://www.ncbi.nlm.nih.gov/gene/?term=653121 "BOZF1, ZBTB8, ZNF916A " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019080 653220 XAGE1B http://www.ncbi.nlm.nih.gov/gene/?term=653220 "CT12.1, CT12.1A, CT12.1B, CTP9, GAGED2, XAGE-1, XAGE1, XAGE1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019081 653226 SRP9P1 http://www.ncbi.nlm.nih.gov/gene/?term=653226 SRP9L1 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019082 6533 SLC6A6 http://www.ncbi.nlm.nih.gov/gene/?term=6533 TAUT mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019083 653423 SPAG11A http://www.ncbi.nlm.nih.gov/gene/?term=653423 "EDDM2A, HE2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019084 653464 SRGAP2C http://www.ncbi.nlm.nih.gov/gene/?term=653464 SRGAP2P1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019085 653567 TMEM236 http://www.ncbi.nlm.nih.gov/gene/?term=653567 "FAM23A, FAM23B, bA162I21.2, bA16O1.2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019086 653567 TMEM236 http://www.ncbi.nlm.nih.gov/gene/?term=653567 "FAM23A, FAM23B, bA162I21.2, bA16O1.2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019087 653567 TMEM236 http://www.ncbi.nlm.nih.gov/gene/?term=653567 "FAM23A, FAM23B, bA162I21.2, bA16O1.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019088 6535 SLC6A8 http://www.ncbi.nlm.nih.gov/gene/?term=6535 "CCDS1, CRT, CRTR, CT1, CTR5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019089 6535 SLC6A8 http://www.ncbi.nlm.nih.gov/gene/?term=6535 "CCDS1, CRT, CRTR, CT1, CTR5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019090 653604 HIST2H3D http://www.ncbi.nlm.nih.gov/gene/?term=653604 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019091 653604 HIST2H3D http://www.ncbi.nlm.nih.gov/gene/?term=653604 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019092 653784 MZT2A http://www.ncbi.nlm.nih.gov/gene/?term=653784 "FAM128A, MOZART2A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019093 653784 MZT2A http://www.ncbi.nlm.nih.gov/gene/?term=653784 "FAM128A, MOZART2A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019094 653820 FAM72B http://www.ncbi.nlm.nih.gov/gene/?term=653820 p17 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019095 653 BMP5 http://www.ncbi.nlm.nih.gov/gene/?term=653 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019096 6541 SLC7A1 http://www.ncbi.nlm.nih.gov/gene/?term=6541 "ATRC1, CAT-1, ERR, HCAT1, REC1L " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019097 6541 SLC7A1 http://www.ncbi.nlm.nih.gov/gene/?term=6541 "ATRC1, CAT-1, ERR, HCAT1, REC1L " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019098 6542 SLC7A2 http://www.ncbi.nlm.nih.gov/gene/?term=6542 "ATRC2, CAT2, HCAT2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019099 6542 SLC7A2 http://www.ncbi.nlm.nih.gov/gene/?term=6542 "ATRC2, CAT2, HCAT2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019100 654319 SNORA5A http://www.ncbi.nlm.nih.gov/gene/?term=654319 "ACA5, ACA5A/B/C " snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019101 654320 SNORA8 http://www.ncbi.nlm.nih.gov/gene/?term=654320 ACA8 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00019102 654320 SNORA8 http://www.ncbi.nlm.nih.gov/gene/?term=654320 ACA8 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019103 654320 SNORA8 http://www.ncbi.nlm.nih.gov/gene/?term=654320 ACA8 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019104 654321 SNORA75 http://www.ncbi.nlm.nih.gov/gene/?term=654321 "SNORA75A, U23 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019105 654322 SNORA13 http://www.ncbi.nlm.nih.gov/gene/?term=654322 ACA13 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019106 654322 SNORA13 http://www.ncbi.nlm.nih.gov/gene/?term=654322 ACA13 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019107 6543 SLC8A2 http://www.ncbi.nlm.nih.gov/gene/?term=6543 NCX2 mRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00019108 654412 FAM138B http://www.ncbi.nlm.nih.gov/gene/?term=654412 "F379, bA395L14.6 " lncRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00019109 654412 FAM138B http://www.ncbi.nlm.nih.gov/gene/?term=654412 "F379, bA395L14.6 " lncRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00019110 654433 PAX8-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=654433 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019111 654434 SNHG20 http://www.ncbi.nlm.nih.gov/gene/?term=654434 "C17orf86, LINC00338, NCRNA00338, SCARNA16HG " lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019112 654462 Kncn http://www.ncbi.nlm.nih.gov/gene/?term=654462 "Kino, L5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019113 654483 BOLA2B http://www.ncbi.nlm.nih.gov/gene/?term=654483 BOLA2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019114 654493 8030494B02Rik http://www.ncbi.nlm.nih.gov/gene/?term=654493 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019115 654494 Gm7337 http://www.ncbi.nlm.nih.gov/gene/?term=654494 EG654494 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019116 6546 SLC8A1 http://www.ncbi.nlm.nih.gov/gene/?term=6546 NCX1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019117 654795 Sdr39u1 http://www.ncbi.nlm.nih.gov/gene/?term=654795 2310014G06Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019118 654796 9530036O11Rik http://www.ncbi.nlm.nih.gov/gene/?term=654796 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019119 654809 4930428O21Rik http://www.ncbi.nlm.nih.gov/gene/?term=654809 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019120 6549 SLC9A2 http://www.ncbi.nlm.nih.gov/gene/?term=6549 NHE2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019121 654 BMP6 http://www.ncbi.nlm.nih.gov/gene/?term=654 "VGR, VGR1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019122 654 BMP6 http://www.ncbi.nlm.nih.gov/gene/?term=654 "VGR, VGR1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019123 6550 SLC9A3 http://www.ncbi.nlm.nih.gov/gene/?term=6550 "DIAR8, NHE-3, NHE3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019124 6553 SLC9A5 http://www.ncbi.nlm.nih.gov/gene/?term=6553 NHE5 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019125 6556 SLC11A1 http://www.ncbi.nlm.nih.gov/gene/?term=6556 "LSH, NRAMP, NRAMP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019126 6556 SLC11A1 http://www.ncbi.nlm.nih.gov/gene/?term=6556 "LSH, NRAMP, NRAMP1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019127 6558 SLC12A2 http://www.ncbi.nlm.nih.gov/gene/?term=6558 "BSC, BSC2, NKCC1, PPP1R141 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019128 6558 SLC12A2 http://www.ncbi.nlm.nih.gov/gene/?term=6558 "BSC, BSC2, NKCC1, PPP1R141 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019129 6558 SLC12A2 http://www.ncbi.nlm.nih.gov/gene/?term=6558 "BSC, BSC2, NKCC1, PPP1R141 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019130 655 BMP7 http://www.ncbi.nlm.nih.gov/gene/?term=655 OP-1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019131 6560 SLC12A4 http://www.ncbi.nlm.nih.gov/gene/?term=6560 KCC1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019132 6561 SLC13A1 http://www.ncbi.nlm.nih.gov/gene/?term=6561 "NAS1, NaSi-1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019133 6561 SLC13A1 http://www.ncbi.nlm.nih.gov/gene/?term=6561 "NAS1, NaSi-1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019134 6561 SLC13A1 http://www.ncbi.nlm.nih.gov/gene/?term=6561 "NAS1, NaSi-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019135 6566 SLC16A1 http://www.ncbi.nlm.nih.gov/gene/?term=6566 "HHF7, MCT, MCT1, MCT1D " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019136 6566 SLC16A1 http://www.ncbi.nlm.nih.gov/gene/?term=6566 "HHF7, MCT, MCT1, MCT1D " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019137 6567 SLC16A2 http://www.ncbi.nlm.nih.gov/gene/?term=6567 "AHDS, DXS128, DXS128E, MCT 7, MCT 8, MCT7, MCT8, MRX22, XPCT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019138 656 BMP8B http://www.ncbi.nlm.nih.gov/gene/?term=656 "BMP8, OP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019139 6573 SLC19A1 http://www.ncbi.nlm.nih.gov/gene/?term=6573 "CHMD, FOLT, IFC1, REFC, RFC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019140 6573 SLC19A1 http://www.ncbi.nlm.nih.gov/gene/?term=6573 "CHMD, FOLT, IFC1, REFC, RFC1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019141 6574 SLC20A1 http://www.ncbi.nlm.nih.gov/gene/?term=6574 "GLVR1, Glvr-1, PIT1, PiT-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019142 6574 SLC20A1 http://www.ncbi.nlm.nih.gov/gene/?term=6574 "GLVR1, Glvr-1, PIT1, PiT-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019143 6574 SLC20A1 http://www.ncbi.nlm.nih.gov/gene/?term=6574 "GLVR1, Glvr-1, PIT1, PiT-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019144 6575 SLC20A2 http://www.ncbi.nlm.nih.gov/gene/?term=6575 "GLVR-2, GLVR2, IBGC1, IBGC3, MLVAR, PIT-2, PIT2, RAM1, Ram-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019145 6576 SLC25A1 http://www.ncbi.nlm.nih.gov/gene/?term=6576 "CTP, D2L2AD, SEA, SLC20A3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019146 6576 SLC25A1 http://www.ncbi.nlm.nih.gov/gene/?term=6576 "CTP, D2L2AD, SEA, SLC20A3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019147 6578 SLCO2A1 http://www.ncbi.nlm.nih.gov/gene/?term=6578 "MATR1, OATP2A1, PGT, PHOAR2, SLC21A2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019148 6579 SLCO1A2 http://www.ncbi.nlm.nih.gov/gene/?term=6579 "OATP, OATP-A, OATP1A2, SLC21A3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019149 6581 SLC22A3 http://www.ncbi.nlm.nih.gov/gene/?term=6581 "EMT, EMTH, OCT3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019150 6583 SLC22A4 http://www.ncbi.nlm.nih.gov/gene/?term=6583 OCTN1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019151 658 BMPR1B http://www.ncbi.nlm.nih.gov/gene/?term=658 "ALK-6, ALK6, AMDD, BDA1D, BDA2, CDw293 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019152 658 BMPR1B http://www.ncbi.nlm.nih.gov/gene/?term=658 "ALK-6, ALK6, AMDD, BDA1D, BDA2, CDw293 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019153 6590 SLPI http://www.ncbi.nlm.nih.gov/gene/?term=6590 "ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019154 6590 SLPI http://www.ncbi.nlm.nih.gov/gene/?term=6590 "ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019155 6595 SMARCA2 http://www.ncbi.nlm.nih.gov/gene/?term=6595 "BAF190, BRM, NCBRS, SNF2, SNF2L2, SNF2LA, SWI2, Sth1p, hBRM, hSNF2a " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019156 6595 SMARCA2 http://www.ncbi.nlm.nih.gov/gene/?term=6595 "BAF190, BRM, NCBRS, SNF2, SNF2L2, SNF2LA, SWI2, Sth1p, hBRM, hSNF2a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019157 65960 Twsg1 http://www.ncbi.nlm.nih.gov/gene/?term=65960 "1810013J15Rik, 9030422N06Rik, AW552143, D17Ertd403e, Tsg, Twg " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019158 65961 Utp3 http://www.ncbi.nlm.nih.gov/gene/?term=65961 "2400011K09Rik, AW557551, C87704, Crl1, Crlz1, Sas10 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019159 65962 Slc9a3r2 http://www.ncbi.nlm.nih.gov/gene/?term=65962 "0610011L07Rik, 1200011K07Rik, 2010007A20Rik, E3karp, NHERF-2, Nherf2, Octs2, Sip-1, Sip1, Sryip1, Tka-1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019160 65967 Eefsec http://www.ncbi.nlm.nih.gov/gene/?term=65967 "Selb, sec " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019161 65971 Tbata http://www.ncbi.nlm.nih.gov/gene/?term=65971 "1700021K02Rik, AI428928, Spatial, Titest " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019162 65973 Asph http://www.ncbi.nlm.nih.gov/gene/?term=65973 "2310005F16Rik, 3110001L23Rik, AI848629, AW261690, AW561901, BAH, C79816, cI-37 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019163 65977 PLEKHA3 http://www.ncbi.nlm.nih.gov/gene/?term=65977 FAPP1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019164 65977 PLEKHA3 http://www.ncbi.nlm.nih.gov/gene/?term=65977 FAPP1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019165 65979 PHACTR4 http://www.ncbi.nlm.nih.gov/gene/?term=65979 PPP1R124 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019166 65979 PHACTR4 http://www.ncbi.nlm.nih.gov/gene/?term=65979 PPP1R124 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019167 6597 SMARCA4 http://www.ncbi.nlm.nih.gov/gene/?term=6597 "BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019168 65980 BRD9 http://www.ncbi.nlm.nih.gov/gene/?term=65980 "LAVS3040, PRO9856 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019169 65985 AACS http://www.ncbi.nlm.nih.gov/gene/?term=65985 "ACSF1, SUR-5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019170 65985 AACS http://www.ncbi.nlm.nih.gov/gene/?term=65985 "ACSF1, SUR-5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019171 65986 ZBTB10 http://www.ncbi.nlm.nih.gov/gene/?term=65986 RINZF mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019172 65987 KCTD14 http://www.ncbi.nlm.nih.gov/gene/?term=65987 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019173 65988 ZNF747 http://www.ncbi.nlm.nih.gov/gene/?term=65988 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019174 65988 ZNF747 http://www.ncbi.nlm.nih.gov/gene/?term=65988 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019175 65989 DLK2 http://www.ncbi.nlm.nih.gov/gene/?term=65989 "DLK-2, EGFL9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019176 6598 SMARCB1 http://www.ncbi.nlm.nih.gov/gene/?term=6598 "BAF47, INI1, MRD15, PPP1R144, RDT, RTPS1, SNF5, SNF5L1, SWNTS1, Sfh1p, Snr1, hSNFS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019177 6598 SMARCB1 http://www.ncbi.nlm.nih.gov/gene/?term=6598 "BAF47, INI1, MRD15, PPP1R144, RDT, RTPS1, SNF5, SNF5L1, SWNTS1, Sfh1p, Snr1, hSNFS " mRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00019178 6598 SMARCB1 http://www.ncbi.nlm.nih.gov/gene/?term=6598 "BAF47, INI1, MRD15, PPP1R144, RDT, RTPS1, SNF5, SNF5L1, SWNTS1, Sfh1p, Snr1, hSNFS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019179 65990 FAM173A http://www.ncbi.nlm.nih.gov/gene/?term=65990 C16orf24 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019180 65991 FUNDC2 http://www.ncbi.nlm.nih.gov/gene/?term=65991 "DC44, HCBP6, HCC3, PD03104 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019181 65991 FUNDC2 http://www.ncbi.nlm.nih.gov/gene/?term=65991 "DC44, HCBP6, HCC3, PD03104 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019182 65992 DDRGK1 http://www.ncbi.nlm.nih.gov/gene/?term=65992 "C20orf116, UFBP1, dJ1187M17.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019183 65992 DDRGK1 http://www.ncbi.nlm.nih.gov/gene/?term=65992 "C20orf116, UFBP1, dJ1187M17.3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019184 65993 MRPS34 http://www.ncbi.nlm.nih.gov/gene/?term=65993 "MRP-S12, MRP-S34, MRPS12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019185 65998 C11orf95 http://www.ncbi.nlm.nih.gov/gene/?term=65998 lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019186 65998 C11orf95 http://www.ncbi.nlm.nih.gov/gene/?term=65998 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019187 65999 LRRC61 http://www.ncbi.nlm.nih.gov/gene/?term=65999 HSPC295 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019188 6599 SMARCC1 http://www.ncbi.nlm.nih.gov/gene/?term=6599 "BAF155, CRACC1, Rsc8, SRG3, SWI3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019189 6599 SMARCC1 http://www.ncbi.nlm.nih.gov/gene/?term=6599 "BAF155, CRACC1, Rsc8, SRG3, SWI3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019190 659 BMPR2 http://www.ncbi.nlm.nih.gov/gene/?term=659 "BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019191 659 BMPR2 http://www.ncbi.nlm.nih.gov/gene/?term=659 "BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019192 66000 TMEM108 http://www.ncbi.nlm.nih.gov/gene/?term=66000 CT124 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019193 66005 CHID1 http://www.ncbi.nlm.nih.gov/gene/?term=66005 "GL008, SI-CLP, SICLP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019194 66005 CHID1 http://www.ncbi.nlm.nih.gov/gene/?term=66005 "GL008, SI-CLP, SICLP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019195 66008 TRAK2 http://www.ncbi.nlm.nih.gov/gene/?term=66008 "ALS2CR3, CALS-C, GRIF-1, GRIF1, MILT2, OIP98 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019196 66008 TRAK2 http://www.ncbi.nlm.nih.gov/gene/?term=66008 "ALS2CR3, CALS-C, GRIF-1, GRIF1, MILT2, OIP98 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019197 6601 SMARCC2 http://www.ncbi.nlm.nih.gov/gene/?term=6601 "BAF170, CRACC2, Rsc8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019198 6602 SMARCD1 http://www.ncbi.nlm.nih.gov/gene/?term=6602 "BAF60A, CRACD1, Rsc6p " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019199 66036 MTMR9 http://www.ncbi.nlm.nih.gov/gene/?term=66036 "C8orf9, LIP-STYX, MTMR8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019200 66036 MTMR9 http://www.ncbi.nlm.nih.gov/gene/?term=66036 "C8orf9, LIP-STYX, MTMR8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019201 66036 MTMR9 http://www.ncbi.nlm.nih.gov/gene/?term=66036 "C8orf9, LIP-STYX, MTMR8 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019202 66036 MTMR9 http://www.ncbi.nlm.nih.gov/gene/?term=66036 "C8orf9, LIP-STYX, MTMR8 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019203 66036 MTMR9 http://www.ncbi.nlm.nih.gov/gene/?term=66036 "C8orf9, LIP-STYX, MTMR8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019204 6603 SMARCD2 http://www.ncbi.nlm.nih.gov/gene/?term=6603 "BAF60B, CRACD2, PRO2451, Rsc6p " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019205 66049 Rogdi http://www.ncbi.nlm.nih.gov/gene/?term=66049 "0610011C19Rik, AU020118, C76152, Lzf " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019206 6604 SMARCD3 http://www.ncbi.nlm.nih.gov/gene/?term=6604 "BAF60C, CRACD3, Rsc6p " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019207 66050 0610009B22Rik http://www.ncbi.nlm.nih.gov/gene/?term=66050 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019208 66054 Cndp2 http://www.ncbi.nlm.nih.gov/gene/?term=66054 "0610010E05Rik, C76600, Cn2, Dip-2, Pep-1, Pep1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019209 66055 Sf3b6 http://www.ncbi.nlm.nih.gov/gene/?term=66055 "0610009D07Rik, 6030419K15Rik, AV001342, Sf3b14 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019210 66056 Zfp524 http://www.ncbi.nlm.nih.gov/gene/?term=66056 "0610012F07Rik, 2300009P13Rik, Znf524 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019211 66058 Tmem176a http://www.ncbi.nlm.nih.gov/gene/?term=66058 "0610011I04Rik, AU040201, AU041743, Keg2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019212 6605 SMARCE1 http://www.ncbi.nlm.nih.gov/gene/?term=6605 BAF57 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019213 6605 SMARCE1 http://www.ncbi.nlm.nih.gov/gene/?term=6605 BAF57 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019214 66070 Cwc15 http://www.ncbi.nlm.nih.gov/gene/?term=66070 "0610040D20Rik, 2900052N06Rik, Ed1, c11orf5, mED1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019215 66074 Tmem167 http://www.ncbi.nlm.nih.gov/gene/?term=66074 "0610041E09Rik, 5730424F14Rik, AU041184, AW537806, ENSMUSG00000060669, Gm10085a, Tmem167 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019216 66074 Tmem167 http://www.ncbi.nlm.nih.gov/gene/?term=66074 "0610041E09Rik, 5730424F14Rik, AU041184, AW537806, ENSMUSG00000060669, Gm10085a, Tmem167 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019217 66075 Chchd3 http://www.ncbi.nlm.nih.gov/gene/?term=66075 "0610041L09Rik, 1700039J09Rik, AW558177 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019218 66078 Tsen34 http://www.ncbi.nlm.nih.gov/gene/?term=66078 "0610027F08Rik, Leng5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019219 6607 SMN2 http://www.ncbi.nlm.nih.gov/gene/?term=6607 "BCD541, C-BCD541, GEMIN1, SMNC, TDRD16B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019220 6607 SMN2 http://www.ncbi.nlm.nih.gov/gene/?term=6607 "BCD541, C-BCD541, GEMIN1, SMNC, TDRD16B " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019221 6607 SMN2 http://www.ncbi.nlm.nih.gov/gene/?term=6607 "BCD541, C-BCD541, GEMIN1, SMNC, TDRD16B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019222 66083 Setd6 http://www.ncbi.nlm.nih.gov/gene/?term=66083 "0610039J04Rik, 3110004G14Rik, AI413388, C76402 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019223 66083 Setd6 http://www.ncbi.nlm.nih.gov/gene/?term=66083 "0610039J04Rik, 3110004G14Rik, AI413388, C76402 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019224 66084 Rmnd1 http://www.ncbi.nlm.nih.gov/gene/?term=66084 "0610042C05Rik, AA408137, AI462664, AW536662 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019225 66087 Emc3 http://www.ncbi.nlm.nih.gov/gene/?term=66087 "0610039A15Rik, AI225901, AW260416, Pob, Tmem111 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019226 66094 Lsm7 http://www.ncbi.nlm.nih.gov/gene/?term=66094 "0910001B06Rik, 1110033F18Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019227 66098 Chchd6 http://www.ncbi.nlm.nih.gov/gene/?term=66098 "0710001P09Rik, 1700021B03Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019228 6609 SMPD1 http://www.ncbi.nlm.nih.gov/gene/?term=6609 "ASM, ASMASE, NPD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019229 66101 Ppih http://www.ncbi.nlm.nih.gov/gene/?term=66101 "1100001J08Rik, 2010111B15Rik, 4833408F11Rik, AI464484, CYP-20, CYPH, D4Wsu43e " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019230 66105 Ube2d3 http://www.ncbi.nlm.nih.gov/gene/?term=66105 "1100001F19Rik, 9430029A22Rik, AA414951 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019231 66118 Sarnp http://www.ncbi.nlm.nih.gov/gene/?term=66118 "1110005A23Rik, Cip29 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019232 66118 Sarnp http://www.ncbi.nlm.nih.gov/gene/?term=66118 "1110005A23Rik, Cip29 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019233 6611 SMS http://www.ncbi.nlm.nih.gov/gene/?term=6611 "MRSR, SPMSY, SRS, SpS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019234 6611 SMS http://www.ncbi.nlm.nih.gov/gene/?term=6611 "MRSR, SPMSY, SRS, SpS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019235 66124 Josd2 http://www.ncbi.nlm.nih.gov/gene/?term=66124 1110007C05Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019236 66126 Elof1 http://www.ncbi.nlm.nih.gov/gene/?term=66126 1110011K10Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019237 6612 SUMO3 http://www.ncbi.nlm.nih.gov/gene/?term=6612 "SMT3A, SMT3H1, SUMO-3, Smt3B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019238 6612 SUMO3 http://www.ncbi.nlm.nih.gov/gene/?term=6612 "SMT3A, SMT3H1, SUMO-3, Smt3B " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019239 6612 SUMO3 http://www.ncbi.nlm.nih.gov/gene/?term=6612 "SMT3A, SMT3H1, SUMO-3, Smt3B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019240 6613 SUMO2 http://www.ncbi.nlm.nih.gov/gene/?term=6613 "HSMT3, SMT3B, SMT3H2, SUMO3, Smt3A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019241 6613 SUMO2 http://www.ncbi.nlm.nih.gov/gene/?term=6613 "HSMT3, SMT3B, SMT3H2, SUMO3, Smt3A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019242 6613 SUMO2 http://www.ncbi.nlm.nih.gov/gene/?term=6613 "HSMT3, SMT3B, SMT3H2, SUMO3, Smt3A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019243 66153 Fbxo36 http://www.ncbi.nlm.nih.gov/gene/?term=66153 "0610008D19Rik, 1110020F21Rik, 2410002G19Rik, D1Ertd757e " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019244 6615 SNAI1 http://www.ncbi.nlm.nih.gov/gene/?term=6615 "SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019245 66163 Mrpl4 http://www.ncbi.nlm.nih.gov/gene/?term=66163 1110017G11Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019246 66167 Tma7 http://www.ncbi.nlm.nih.gov/gene/?term=66167 "1110017O22Rik, Ccdc72 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019247 6616 SNAP25 http://www.ncbi.nlm.nih.gov/gene/?term=6616 "CMS18, RIC-4, RIC4, SEC9, SNAP, SNAP-25, bA416N4.2, dJ1068F16.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019248 66170 Chchd5 http://www.ncbi.nlm.nih.gov/gene/?term=66170 "1110027L01Rik, AW045710 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019249 66171 Pgls http://www.ncbi.nlm.nih.gov/gene/?term=66171 "1110030K05Rik, AI447866, Plgs " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019250 66171 Pgls http://www.ncbi.nlm.nih.gov/gene/?term=66171 "1110030K05Rik, AI447866, Plgs " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019251 66172 Med11 http://www.ncbi.nlm.nih.gov/gene/?term=66172 "1110030J09Rik, AI465144, AW545069 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019252 66174 Nudt14 http://www.ncbi.nlm.nih.gov/gene/?term=66174 "1110030M18Rik, UGPPase " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019253 66177 Ubl5 http://www.ncbi.nlm.nih.gov/gene/?term=66177 "1110030M22Rik, beacon " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019254 66181 Nop10 http://www.ncbi.nlm.nih.gov/gene/?term=66181 "1110036B12Rik, NOP10P, Nola3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019255 66181 Nop10 http://www.ncbi.nlm.nih.gov/gene/?term=66181 "1110036B12Rik, NOP10P, Nola3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019256 66185 1110037F02Rik http://www.ncbi.nlm.nih.gov/gene/?term=66185 "4930422M05Rik, Kiaa1429, mKIAA1429 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019257 6618 SNAPC2 http://www.ncbi.nlm.nih.gov/gene/?term=6618 "PTFDELTA, SNAP45 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019258 6618 SNAPC2 http://www.ncbi.nlm.nih.gov/gene/?term=6618 "PTFDELTA, SNAP45 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019259 66191 Ier3ip1 http://www.ncbi.nlm.nih.gov/gene/?term=66191 "1110057H19Rik, AI644142, AL022842, AL022863, AV026606 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019260 66194 Pycrl http://www.ncbi.nlm.nih.gov/gene/?term=66194 "1110058B13Rik, 2700073G24Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019261 66196 Myo19 http://www.ncbi.nlm.nih.gov/gene/?term=66196 "1110055A02Rik, Myohd1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019262 66197 Cks2 http://www.ncbi.nlm.nih.gov/gene/?term=66197 "1110038L14Rik, CKSHS2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019263 6619 SNAPC3 http://www.ncbi.nlm.nih.gov/gene/?term=6619 "PTFbeta, SNAP50 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019264 6619 SNAPC3 http://www.ncbi.nlm.nih.gov/gene/?term=6619 "PTFbeta, SNAP50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019265 661 POLR3D http://www.ncbi.nlm.nih.gov/gene/?term=661 "BN51T, RPC4, RPC53, TSBN51 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019266 66204 Acyp1 http://www.ncbi.nlm.nih.gov/gene/?term=66204 "1110039O14Rik, AI325944 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019267 66205 Cd302 http://www.ncbi.nlm.nih.gov/gene/?term=66205 "1110055L24Rik, AI159627 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019268 66212 Sec61b http://www.ncbi.nlm.nih.gov/gene/?term=66212 "1190006C12Rik, AI326121, AW122942 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019269 66213 Med7 http://www.ncbi.nlm.nih.gov/gene/?term=66213 "1110063B05Rik, Crsp33, Crsp9 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019270 66223 Mrpl35 http://www.ncbi.nlm.nih.gov/gene/?term=66223 1110066C01Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019271 66226 Trappc2 http://www.ncbi.nlm.nih.gov/gene/?term=66226 "1110066L09Rik, 1810064C02Rik, AW496358, MIP-2A, Sedl, TRS20 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019272 6622 SNCA http://www.ncbi.nlm.nih.gov/gene/?term=6622 "NACP, PARK1, PARK4, PD1 " mRNA Homo sapiens 25896939 Synapse Nerve cell qRT-PCR|Immunocytochemistry "Consistent with the localization studies in the rat ENS, we observed similar staining pattern of a-syn in the human ENS decorating both enteric ganglia and nerve fibers. Again, the granular/punctuate a-syn immunoreactive signals co-localized with immunoreactive signals obtained for synaptophysin confirming the association of a-syn with the synaptic vesicle apparatus also within the human ENS. " RLID00019273 6622 SNCA http://www.ncbi.nlm.nih.gov/gene/?term=6622 "NACP, PARK1, PARK4, PD1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019274 66231 Thoc7 http://www.ncbi.nlm.nih.gov/gene/?term=66231 Nif3l1bp1 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019275 66234 Msmo1 http://www.ncbi.nlm.nih.gov/gene/?term=66234 "1500001G16Rik, C78600, DESP4, ERG25, Sc4mol " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019276 66235 Eif1ax http://www.ncbi.nlm.nih.gov/gene/?term=66235 "1500010B24Rik, AI426898, Eif1ay " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019277 66236 1500011B03Rik http://www.ncbi.nlm.nih.gov/gene/?term=66236 "AI415201, AV141149, AW556386 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019278 6623 SNCG http://www.ncbi.nlm.nih.gov/gene/?term=6623 "BCSG1, SR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019279 66244 Nemf http://www.ncbi.nlm.nih.gov/gene/?term=66244 "1500011I12Rik, 4933405E14Rik, Sdccag1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019280 66245 Hspbp1 http://www.ncbi.nlm.nih.gov/gene/?term=66245 1500019G21Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019281 66246 Osgep http://www.ncbi.nlm.nih.gov/gene/?term=66246 "1500019L24Rik, GCPL-1, PRSMG1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019282 66249 Pno1 http://www.ncbi.nlm.nih.gov/gene/?term=66249 "1810003N24Rik, AA407421, AU015468, AU019495, AU042323, Emi3, Imi3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019283 6624 FSCN1 http://www.ncbi.nlm.nih.gov/gene/?term=6624 "FAN1, HSN, SNL, p55 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019284 6625 SNRNP70 http://www.ncbi.nlm.nih.gov/gene/?term=6625 "RNPU1Z, RPU1, SNRP70, Snp1, U1-70K, U170K, U1AP, U1RNP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019285 66268 Pigyl http://www.ncbi.nlm.nih.gov/gene/?term=66268 "1810008A14Rik, PIG-Y, Pigy " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019286 6626 SNRPA http://www.ncbi.nlm.nih.gov/gene/?term=6626 "Mud1, U1-A, U1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019287 6626 SNRPA http://www.ncbi.nlm.nih.gov/gene/?term=6626 "Mud1, U1-A, U1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019288 66270 Fam134b http://www.ncbi.nlm.nih.gov/gene/?term=66270 "1810015C04Rik, AU015349 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019289 66271 Tmem126a http://www.ncbi.nlm.nih.gov/gene/?term=66271 1810020E01Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019290 6627 SNRPA1 http://www.ncbi.nlm.nih.gov/gene/?term=6627 Lea1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019291 66286 Sec11c http://www.ncbi.nlm.nih.gov/gene/?term=66286 "1810029G24Rik, Sec11l3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019292 6628 SNRPB http://www.ncbi.nlm.nih.gov/gene/?term=6628 "CCMS, COD1, Sm-B/B', SmB/B', SmB/SmB', snRNP-B, SNRPB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019293 6628 SNRPB http://www.ncbi.nlm.nih.gov/gene/?term=6628 "CCMS, COD, SNRPB1, Sm-B/B', SmB/B', SmB/SmB', snRNP-B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019294 66293 1810032O08Rik http://www.ncbi.nlm.nih.gov/gene/?term=66293 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019295 6629 SNRPB2 http://www.ncbi.nlm.nih.gov/gene/?term=6629 "Msl1, U2B'' " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019296 6629 SNRPB2 http://www.ncbi.nlm.nih.gov/gene/?term=6629 Msl1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019297 662 BNIP1 http://www.ncbi.nlm.nih.gov/gene/?term=662 "NIP1, SEC20, TRG-8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019298 66307 Isoc1 http://www.ncbi.nlm.nih.gov/gene/?term=66307 2610034N03Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019299 66308 Mplkip http://www.ncbi.nlm.nih.gov/gene/?term=66308 "2810021B07Rik, C330007M08Rik, Ttdn1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019300 66309 Tmem128 http://www.ncbi.nlm.nih.gov/gene/?term=66309 2810021O14Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019301 66313 Smurf2 http://www.ncbi.nlm.nih.gov/gene/?term=66313 "2810411E22Rik, AI558114, AI649275 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019302 66315 Senp7 http://www.ncbi.nlm.nih.gov/gene/?term=66315 "2410152H17Rik, 2810413I22Rik, 2900036C23Rik, 6030449K19Rik, AI790676 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019303 6631 SNRPC http://www.ncbi.nlm.nih.gov/gene/?term=6631 "U1C, Yhc1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019304 6631 SNRPC http://www.ncbi.nlm.nih.gov/gene/?term=6631 "U1C, Yhc1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019305 6632 SNRPD1 http://www.ncbi.nlm.nih.gov/gene/?term=6632 "HsT2456, SMD1, SNRPD, Sm-D1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019306 6632 SNRPD1 http://www.ncbi.nlm.nih.gov/gene/?term=6632 "HsT2456, SMD1, SNRPD, Sm-D1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019307 6632 SNRPD1 http://www.ncbi.nlm.nih.gov/gene/?term=6632 "HsT2456, SMD1, SNRPD, Sm-D1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019308 66335 Atp6v1c1 http://www.ncbi.nlm.nih.gov/gene/?term=66335 "1700025B18Rik, U13839 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019309 66336 Cenpp http://www.ncbi.nlm.nih.gov/gene/?term=66336 "1700022C02Rik, 4921518G09Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019310 6633 SNRPD2 http://www.ncbi.nlm.nih.gov/gene/?term=6633 "SMD2, SNRPD1, Sm-D2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019311 6633 SNRPD2 http://www.ncbi.nlm.nih.gov/gene/?term=6633 "SMD2, SNRPD1, Sm-D2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019312 6634 SNRPD3 http://www.ncbi.nlm.nih.gov/gene/?term=6634 "SMD3, Sm-D3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019313 66352 Blzf1 http://www.ncbi.nlm.nih.gov/gene/?term=66352 "1700030G05Rikl, Golgin-45, Jem-1, Blzf1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019314 66352 Blzf1 http://www.ncbi.nlm.nih.gov/gene/?term=66352 "1700030G05Rikl, Golgin-45, Jem-1, Blzf1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019315 66354 Snw1 http://www.ncbi.nlm.nih.gov/gene/?term=66354 "2310008B08Rik, AW048543, NCoA-62, SKIP, Skiip " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019316 66355 Gmpr http://www.ncbi.nlm.nih.gov/gene/?term=66355 "2310004P21Rik, AV028449, GMPR 1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019317 66356 Knop1 http://www.ncbi.nlm.nih.gov/gene/?term=66356 "2310008H09Rik, Tsg118 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019318 6635 SNRPE http://www.ncbi.nlm.nih.gov/gene/?term=6635 "B-raf, HYPT11, SME, Sm-E " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019319 6635 SNRPE http://www.ncbi.nlm.nih.gov/gene/?term=6635 "B-raf, HYPT11, SME, Sm-E " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019320 66361 Zfand1 http://www.ncbi.nlm.nih.gov/gene/?term=66361 "2310008M20Rik, AW048890 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019321 66368 Rtca http://www.ncbi.nlm.nih.gov/gene/?term=66368 "2310009A18Rik, AI450277, RPC, Rtcd1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019322 6636 SNRPF http://www.ncbi.nlm.nih.gov/gene/?term=6636 "SMF, Sm-F, snRNP-F " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019323 6636 SNRPF http://www.ncbi.nlm.nih.gov/gene/?term=6636 "SMF, Sm-F, snRNP-F " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019324 66374 2310011J03Rik http://www.ncbi.nlm.nih.gov/gene/?term=66374 "AI452186, AW545358 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019325 66377 Ndufc1 http://www.ncbi.nlm.nih.gov/gene/?term=66377 "2310016K22Rik, KFYI " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019326 6637 SNRPG http://www.ncbi.nlm.nih.gov/gene/?term=6637 "SMG, Sm-G " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019327 6637 SNRPG http://www.ncbi.nlm.nih.gov/gene/?term=6637 "SMG, Sm-G " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019328 66381 Rnf113a2 http://www.ncbi.nlm.nih.gov/gene/?term=66381 "2310020H19Rik, AI426758, Rnf113a " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019329 66384 Srp19 http://www.ncbi.nlm.nih.gov/gene/?term=66384 2310020D23Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019330 66385 Ppp1r7 http://www.ncbi.nlm.nih.gov/gene/?term=66385 "2310014J01Rik, SDS22 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019331 66387 Nudt8 http://www.ncbi.nlm.nih.gov/gene/?term=66387 2310039H17Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019332 6638 SNRPN http://www.ncbi.nlm.nih.gov/gene/?term=6638 "HCERN3, PWCR, RT-LI, SM-D, SMN, SNRNP-N, SNURF-SNRPN, sm-N " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019333 66394 Nosip http://www.ncbi.nlm.nih.gov/gene/?term=66394 "2310061K06Rik, CGI-25 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019334 66395 Ahnak http://www.ncbi.nlm.nih.gov/gene/?term=66395 DY6 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019335 66395 Ahnak http://www.ncbi.nlm.nih.gov/gene/?term=66395 DY6 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019336 66397 Sar1b http://www.ncbi.nlm.nih.gov/gene/?term=66397 "2310075M17Rik, 2900019I22Rik, CMRD, Sara1b, Sara2, Sarb " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019337 66398 Commd5 http://www.ncbi.nlm.nih.gov/gene/?term=66398 "2310065H03Rik, AI854466, D15Ertd81e, Hcarg " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019338 663 BNIP2 http://www.ncbi.nlm.nih.gov/gene/?term=663 "BNIP-2, NIP2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019339 663 BNIP2 http://www.ncbi.nlm.nih.gov/gene/?term=663 "BNIP-2, NIP2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019340 663 BNIP2 http://www.ncbi.nlm.nih.gov/gene/?term=663 "BNIP-2, NIP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019341 6640 SNTA1 http://www.ncbi.nlm.nih.gov/gene/?term=6640 "LQT12, SNT1, TACIP1, dJ1187J4.5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019342 66410 Mterf3 http://www.ncbi.nlm.nih.gov/gene/?term=66410 "2410017I18Rik, Mterfd1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019343 66413 Psmd6 http://www.ncbi.nlm.nih.gov/gene/?term=66413 2400006A19Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019344 66414 Ndufa12 http://www.ncbi.nlm.nih.gov/gene/?term=66414 "2410011G03Rik, AW112974 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019345 6641 SNTB1 http://www.ncbi.nlm.nih.gov/gene/?term=6641 "59-DAP, A1B, BSYN2, DAPA1B, SNT2, SNT2B1, TIP-43 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019346 66421 2410004B18Rik http://www.ncbi.nlm.nih.gov/gene/?term=66421 4930572C24Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019347 66423 Coprs http://www.ncbi.nlm.nih.gov/gene/?term=66423 "1700029I03Rik, 2410022L05Rik, AA409325, AI256813, C85432, Copr5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019348 66425 Pcp4l1 http://www.ncbi.nlm.nih.gov/gene/?term=66425 1500036F01Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019349 66427 Cyb5b http://www.ncbi.nlm.nih.gov/gene/?term=66427 "1810044O22Rik, AU015618, Cyb5m " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019350 6642 SNX1 http://www.ncbi.nlm.nih.gov/gene/?term=6642 "HsT17379, VPS5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019351 6642 SNX1 http://www.ncbi.nlm.nih.gov/gene/?term=6642 "HsT17379, VPS5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019352 6642 SNX1 http://www.ncbi.nlm.nih.gov/gene/?term=6642 "HsT17379, VPS5 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019353 6642 SNX1 http://www.ncbi.nlm.nih.gov/gene/?term=6642 "HsT17379, VPS5 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019354 6642 SNX1 http://www.ncbi.nlm.nih.gov/gene/?term=6642 "HsT17379, VPS5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019355 66432 Slc7a6os http://www.ncbi.nlm.nih.gov/gene/?term=66432 "2010007L18Rik, 2400002F02Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019356 66435 Uggt2 http://www.ncbi.nlm.nih.gov/gene/?term=66435 "1810064L21Rik, 3110001A05Rik, 3110027P15Rik, A230065J02Rik, AW047562, Ugcgl2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019357 66437 Fis1 http://www.ncbi.nlm.nih.gov/gene/?term=66437 "2010003O14Rik, Ttc11 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019358 6643 SNX2 http://www.ncbi.nlm.nih.gov/gene/?term=6643 TRG-9 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019359 6643 SNX2 http://www.ncbi.nlm.nih.gov/gene/?term=6643 TRG-9 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019360 6643 SNX2 http://www.ncbi.nlm.nih.gov/gene/?term=6643 TRG-9 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019361 66441 Magohb http://www.ncbi.nlm.nih.gov/gene/?term=66441 "2010012C16Rik, Mago, Magoh, Magoh-rs1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019362 66442 Spc25 http://www.ncbi.nlm.nih.gov/gene/?term=66442 "2600017H08Rik, 2610205L13Rik, Spbc25 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019363 66443 Tnfaip8l1 http://www.ncbi.nlm.nih.gov/gene/?term=66443 "2600017J23Rik, TIPE1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019364 66447 Mgst3 http://www.ncbi.nlm.nih.gov/gene/?term=66447 "2010012L10Rik, 2010306B17Rik, 2700004G04Rik, AA516734, GST-III " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019365 66449 Pam16 http://www.ncbi.nlm.nih.gov/gene/?term=66449 "2010110I09Rik, AV006767, CGI-136, Magmas, Tim16, Timm16 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019366 66455 Cnpy4 http://www.ncbi.nlm.nih.gov/gene/?term=66455 2610019P18Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019367 6645 SNTB2 http://www.ncbi.nlm.nih.gov/gene/?term=6645 "D16S2531E, EST25263, SNT2B2, SNT3, SNTL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019368 6645 SNTB2 http://www.ncbi.nlm.nih.gov/gene/?term=6645 "D16S2531E, EST25263, SNT2B2, SNT3, SNTL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019369 6645 SNTB2 http://www.ncbi.nlm.nih.gov/gene/?term=6645 "D16S2531E, EST25263, SNT2B2, SNT3, SNTL " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019370 6645 SNTB2 http://www.ncbi.nlm.nih.gov/gene/?term=6645 "D16S2531E, EST25263, SNT2B2, SNT3, SNTL " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019371 6645 SNTB2 http://www.ncbi.nlm.nih.gov/gene/?term=6645 "D16S2531E, EST25263, SNT2B2, SNT3, SNTL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019372 66462 2810428I15Rik http://www.ncbi.nlm.nih.gov/gene/?term=66462 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019373 6646 SOAT1 http://www.ncbi.nlm.nih.gov/gene/?term=6646 "ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019374 6646 SOAT1 http://www.ncbi.nlm.nih.gov/gene/?term=6646 "ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019375 664701 ZNF826P http://www.ncbi.nlm.nih.gov/gene/?term=664701 ZNF826 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019376 664701 ZNF826P http://www.ncbi.nlm.nih.gov/gene/?term=664701 ZNF826 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019377 66473 Ctrb1 http://www.ncbi.nlm.nih.gov/gene/?term=66473 "2200008D09Rik, AI504462, Ctrb, Prt-2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019378 66475 Rps23 http://www.ncbi.nlm.nih.gov/gene/?term=66475 2410044J15Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019379 66475 Rps23 http://www.ncbi.nlm.nih.gov/gene/?term=66475 2410044J15Rik mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00019380 664779 Zfp91Cntf http://www.ncbi.nlm.nih.gov/gene/?term=664779 Zfp91-Cntf mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019381 6647 SOD1 http://www.ncbi.nlm.nih.gov/gene/?term=6647 "ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019382 6647 SOD1 http://www.ncbi.nlm.nih.gov/gene/?term=6647 "ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019383 6647 SOD1 http://www.ncbi.nlm.nih.gov/gene/?term=6647 "ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019384 66480 Rpl15 http://www.ncbi.nlm.nih.gov/gene/?term=66480 2510008H07Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019385 66480 Rpl15 http://www.ncbi.nlm.nih.gov/gene/?term=66480 2510008H07Rik mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00019386 66481 Rps21 http://www.ncbi.nlm.nih.gov/gene/?term=66481 "1810049N11Rik, 2410030A14Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019387 66481 Rps21 http://www.ncbi.nlm.nih.gov/gene/?term=66481 "1810049N11Rik, 2410030A14Rik " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00019388 664829 Slx http://www.ncbi.nlm.nih.gov/gene/?term=664829 "EG664958, Xmr " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00019389 66482 Exoc2 http://www.ncbi.nlm.nih.gov/gene/?term=66482 "2410030I24Rik, AI648199, Sec5, Sec5l1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019390 66489 Rpl35 http://www.ncbi.nlm.nih.gov/gene/?term=66489 2410039E09Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019391 6648 SOD2 http://www.ncbi.nlm.nih.gov/gene/?term=6648 "IPOB, MNSOD, MVCD6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019392 6648 SOD2 http://www.ncbi.nlm.nih.gov/gene/?term=6648 "IPOB, MNSOD, MVCD6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019393 664903 Rps15a-ps4 http://www.ncbi.nlm.nih.gov/gene/?term=664903 "Gm13253, Lethe, OTTMUSG00000011114 " lncRNA Mus musculus 23898399 Nucleus 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00019394 664903 Rps15a-ps4 http://www.ncbi.nlm.nih.gov/gene/664903 "Lethe, Gm13253, OTTMUSG00000011114 " lncRNA Mus musculus 23898399 Nucleus 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00019395 66492 Zmat2 http://www.ncbi.nlm.nih.gov/gene/?term=66492 "2610510D14Rik, 2900082I05Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019396 66494 Prelid1 http://www.ncbi.nlm.nih.gov/gene/?term=66494 "2610524G07Rik, Preli " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019397 664968 Tmem238 http://www.ncbi.nlm.nih.gov/gene/?term=664968 2210411K11Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019398 66496 Ppdpf http://www.ncbi.nlm.nih.gov/gene/?term=66496 "0610012G23Rik, 2610317A05Rik, 2700038C09Rik, 3110053G12Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019399 66498 Dda1 http://www.ncbi.nlm.nih.gov/gene/?term=66498 "1500034J01Rik, 1700095J19Rik, R74921 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019400 6649 SOD3 http://www.ncbi.nlm.nih.gov/gene/?term=6649 EC-SOD mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019401 664 BNIP3 http://www.ncbi.nlm.nih.gov/gene/?term=664 NIP3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019402 664 BNIP3 http://www.ncbi.nlm.nih.gov/gene/?term=664 NIP3 mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00019403 665033 Col6a5 http://www.ncbi.nlm.nih.gov/gene/?term=665033 "Col29a1, EG665033, Gm7455 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019404 66505 Zmynd11 http://www.ncbi.nlm.nih.gov/gene/?term=66505 "2210402G22Rik, BS69 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019405 66506 Psmg3 http://www.ncbi.nlm.nih.gov/gene/?term=66506 "1810042K04Rik, 4930403H09Rik, AI303239 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019406 66508 Lamtor1 http://www.ncbi.nlm.nih.gov/gene/?term=66508 "2400001E08Rik, Pdro, p18 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019407 665113 Tnik http://www.ncbi.nlm.nih.gov/gene/?term=665113 "1500031A17Rik, 4831440I19Rik, AI451411, C530008O15Rik, C630040K21Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019408 66511 Chtop http://www.ncbi.nlm.nih.gov/gene/?term=66511 "2500003M10Rik, Fop, Srag " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019409 6651 SON http://www.ncbi.nlm.nih.gov/gene/?term=6651 "BASS1, C21orf50, DBP-5, NREBP3, SON " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019410 6651 SON http://www.ncbi.nlm.nih.gov/gene/?term=6651 "BASS1, C21orf50, DBP-5, NREBP, SON3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019411 66522 Pgpep1 http://www.ncbi.nlm.nih.gov/gene/?term=66522 "2810003H13Rik, Gm19458, PAP-I, PGP, PGP-I, PGPI, Pcp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019412 6652 SORD http://www.ncbi.nlm.nih.gov/gene/?term=6652 "HEL-S-95n1, SORD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019413 66530 Ubxn6 http://www.ncbi.nlm.nih.gov/gene/?term=66530 "1200008L11Rik, 2210415J11Rik, AU040909, Ubxd1, Ubxdc2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019414 6653 SORL1 http://www.ncbi.nlm.nih.gov/gene/?term=6653 "C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019415 6653 SORL1 http://www.ncbi.nlm.nih.gov/gene/?term=6653 "C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019416 6654 SOS1 http://www.ncbi.nlm.nih.gov/gene/?term=6654 "GF1, GGF1, GINGF, HGF, NS4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019417 66552 Sppl2a http://www.ncbi.nlm.nih.gov/gene/?term=66552 "2010106G01Rik, C130089K23Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019418 66566 Ntpcr http://www.ncbi.nlm.nih.gov/gene/?term=66566 "2310079N02Rik, AI449709 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019419 66568 Rwdd3 http://www.ncbi.nlm.nih.gov/gene/?term=66568 "2510027J23Rik, 3110037C01Rik, AI035684, AI662458, Rsume, X2CR1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019420 66569 Gdpd1 http://www.ncbi.nlm.nih.gov/gene/?term=66569 2610020H15Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019421 665797 Gm7788 http://www.ncbi.nlm.nih.gov/gene/?term=665797 EG665797 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019422 66579 2610007O09Rik http://www.ncbi.nlm.nih.gov/gene/?term=66579 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019423 6657 SOX2 http://www.ncbi.nlm.nih.gov/gene/?term=6657 "ANOP3, MCOPS3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019424 66589 Ube2v1 http://www.ncbi.nlm.nih.gov/gene/?term=66589 "0610011J09Rik, AI256840, CROC-1, CROC1, D7Bwg1382e, UEV-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019425 66595 Aste1 http://www.ncbi.nlm.nih.gov/gene/?term=66595 "1100001A21Rik, AV006403 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019426 66599 Rdm1 http://www.ncbi.nlm.nih.gov/gene/?term=66599 "2410008M22Rik, AW212028, Rad52b " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019427 6659 SOX4 http://www.ncbi.nlm.nih.gov/gene/?term=6659 EVI16 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019428 6659 SOX4 http://www.ncbi.nlm.nih.gov/gene/?term=6659 EVI16 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019429 6659 SOX4 http://www.ncbi.nlm.nih.gov/gene/?term=6659 EVI16 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019430 665 BNIP3L http://www.ncbi.nlm.nih.gov/gene/?term=665 "BNIP3a, NIX " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019431 665 BNIP3L http://www.ncbi.nlm.nih.gov/gene/?term=665 "BNIP3a, NIX " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00019432 665 BNIP3L http://www.ncbi.nlm.nih.gov/gene/?term=665 "BNIP3a, NIX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019433 66602 1700020I14Rik http://www.ncbi.nlm.nih.gov/gene/?term=66602 "1190006L01Rik, 4933437I03Rik, AI451541, AI585852, AW538376, AW558897, Cyrano " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019434 66603 Gemin2 http://www.ncbi.nlm.nih.gov/gene/?term=66603 "Sip1, gemin-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019435 66606 Lrrc57 http://www.ncbi.nlm.nih.gov/gene/?term=66606 "2810002D13Rik, AA407405 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019436 66609 Cryzl1 http://www.ncbi.nlm.nih.gov/gene/?term=66609 "2210407J23Rik, 2410006O11Rik, QOH-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019437 66614 Gpatch4 http://www.ncbi.nlm.nih.gov/gene/?term=66614 "2610029K21Rik, Gpatc4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019438 66617 Ntmt1 http://www.ncbi.nlm.nih.gov/gene/?term=66617 "2610205E22Rik, AL033331, AL033332, Mettl11a, NTM1A " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019439 666214 1700049E17Rik1 http://www.ncbi.nlm.nih.gov/gene/?term=666214 1700049E17Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019440 666231 Gm7993 http://www.ncbi.nlm.nih.gov/gene/?term=666231 EG666231 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019441 66625 Pnisr http://www.ncbi.nlm.nih.gov/gene/?term=66625 "5730406M06Rik, AA673174, Pinsr, Sfrs18, Srsf18 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019442 66629 Golph3 http://www.ncbi.nlm.nih.gov/gene/?term=66629 "4733401N08Rik, 5730410D03Rik, AW413496 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019443 6662 SOX9 http://www.ncbi.nlm.nih.gov/gene/?term=6662 "CMD1, CMPD1, SRA1, SRXX2, SRXY10 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019444 666317 Prl2c1 http://www.ncbi.nlm.nih.gov/gene/?term=666317 Ghd22 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019445 66631 Mfsd14b http://www.ncbi.nlm.nih.gov/gene/?term=66631 "5730414C17Rik, AU045608, AW539692, Hiatl1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019446 66632 Dph6 http://www.ncbi.nlm.nih.gov/gene/?term=66632 "5730421E18Rik, Atpbd4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019447 66632 Dph6 http://www.ncbi.nlm.nih.gov/gene/?term=66632 "5730421E18Rik, Atpbd4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019448 66634 Mcm8 http://www.ncbi.nlm.nih.gov/gene/?term=66634 5730432L01Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019449 66640 Hoxaas2 http://www.ncbi.nlm.nih.gov/gene/?term=66640 "2810043O09Rik, 5730446D14Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019450 66641 Sike1 http://www.ncbi.nlm.nih.gov/gene/?term=66641 "2810005O12Rik, 5730470L24Rik, AI450236, AI839862, Sike, Sikeb " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019451 66646 Rpe http://www.ncbi.nlm.nih.gov/gene/?term=66646 "2810429B02Rik, 5730518J08Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019452 66647 Ndnl2 http://www.ncbi.nlm.nih.gov/gene/?term=66647 "5730494G16Rik, AI642138, BB044375, HCA4, Mageg1, Nsmce3, mage-g1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019453 666529 Gm8149 http://www.ncbi.nlm.nih.gov/gene/?term=666529 EG666529 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019454 66658 Ccdc51 http://www.ncbi.nlm.nih.gov/gene/?term=66658 "5730568A12Rik, AI551049 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019455 66660 Sltm http://www.ncbi.nlm.nih.gov/gene/?term=66660 "5730455C01Rik, 5730555F13Rik, 9130215G10Rik, Met " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019456 66661 Srp72 http://www.ncbi.nlm.nih.gov/gene/?term=66661 "5730576P14Rik, 72kDa, AI132477, BC019196, C77589 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019457 66662 Fbxl12os http://www.ncbi.nlm.nih.gov/gene/?term=66662 5730577I03Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019458 66663 Uba5 http://www.ncbi.nlm.nih.gov/gene/?term=66663 "5730525G14Rik, AW240750, Ube1dc1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019459 6666 SOX12 http://www.ncbi.nlm.nih.gov/gene/?term=6666 SOX22 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019460 6666 SOX12 http://www.ncbi.nlm.nih.gov/gene/?term=6666 SOX22 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019461 66671 Ccnh http://www.ncbi.nlm.nih.gov/gene/?term=66671 "6330408H09Rik, AI661354, AV102684, AW538719 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019462 666737 4632427E13Rik http://www.ncbi.nlm.nih.gov/gene/?term=666737 AU015482 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019463 6667 SP1 http://www.ncbi.nlm.nih.gov/gene/?term=6667 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019464 6667 SP1 http://www.ncbi.nlm.nih.gov/gene/?term=6667 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019465 6667 SP1 http://www.ncbi.nlm.nih.gov/gene/?term=6667 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019466 66689 Klhl28 http://www.ncbi.nlm.nih.gov/gene/?term=66689 "2810440N09Rik, 4122402F11Rik, 4931401E10Rik, Btbd5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019467 6668 SP2 http://www.ncbi.nlm.nih.gov/gene/?term=6668 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019468 66691 Gapvd1 http://www.ncbi.nlm.nih.gov/gene/?term=66691 "2010005B09Rik, 4432404J10Rik, AW108497, Gapex-5, RAP6, RME-6, mKIAA1521 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019469 666 BOK http://www.ncbi.nlm.nih.gov/gene/?term=666 "BCL2L9L, BOK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019470 666 BOK http://www.ncbi.nlm.nih.gov/gene/?term=666 "BCL2L9, BOKL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019471 66705 Dnase1l2 http://www.ncbi.nlm.nih.gov/gene/?term=66705 4733401H14Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019472 6670 SP3 http://www.ncbi.nlm.nih.gov/gene/?term=6670 SPR2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019473 66713 Actr2 http://www.ncbi.nlm.nih.gov/gene/?term=66713 "4921510D23Rik, AA409782, Arp2, D6Ertd746e " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019474 66719 4921522P10Rik http://www.ncbi.nlm.nih.gov/gene/?term=66719 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019475 66724 Tab3 http://www.ncbi.nlm.nih.gov/gene/?term=66724 "4921526G09Rik, Map3k7ip3, mKIAA4135 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019476 667257 Gm8541 http://www.ncbi.nlm.nih.gov/gene/?term=667257 EG667257 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019477 66725 Lrrk2 http://www.ncbi.nlm.nih.gov/gene/?term=66725 "4921513O20Rik, 9330188B09Rik, AW561911, D630001M17Rik, Gm927, cI-46 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019478 667281 H60b http://www.ncbi.nlm.nih.gov/gene/?term=667281 EG667281 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019479 6672 SP100 http://www.ncbi.nlm.nih.gov/gene/?term=6672 lysp100b mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019480 6672 SP100 http://www.ncbi.nlm.nih.gov/gene/?term=6672 lysp100b mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019481 66734 Map1lc3a http://www.ncbi.nlm.nih.gov/gene/?term=66734 "1010001H21Rik, 4922501H04Rik, LC3, LC3a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019482 66736 Emc2 http://www.ncbi.nlm.nih.gov/gene/?term=66736 "4921531G14Rik, AV060620, AW209495, Ttc35 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019483 66740 4931417E11Rik http://www.ncbi.nlm.nih.gov/gene/?term=66740 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019484 66748 Erich2 http://www.ncbi.nlm.nih.gov/gene/?term=66748 4933404M02Rik mRNA Mus musculus 26071953 Nucleus Sperm RT-PCR "Within this set of RNAs, the Prm1 transcript, as well as Erich2 and Fam71e2 (formerly 4933404M02Rik and 4930401F20Rik, respectively), were previously identified within the mouse sperm nucleus by RT-PCR though their preferential localization within the gamete could not be inferred from that study (15). " RLID00019485 66753 Erlec1 http://www.ncbi.nlm.nih.gov/gene/?term=66753 4933407N01Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019486 66759 4933425D22Rik http://www.ncbi.nlm.nih.gov/gene/?term=66759 AI606871 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019487 6675 UAP1 http://www.ncbi.nlm.nih.gov/gene/?term=6675 "AGX, AGX1, AGX2, SPAG2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019488 6675 UAP1 http://www.ncbi.nlm.nih.gov/gene/?term=6675 "AGX, AGX1, AGX2, SPAG2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019489 66775 Hacd4 http://www.ncbi.nlm.nih.gov/gene/?term=66775 "4933428I03Rik, Hcad4, Ptplad2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019490 66776 Pisd-ps3 http://www.ncbi.nlm.nih.gov/gene/?term=66776 4933439C20Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019491 6677 SPAM1 http://www.ncbi.nlm.nih.gov/gene/?term=6677 "HEL-S-96n, HYA1, HYAL1, HYAL3, HYAL5, PH-20, PH20, SPAG15 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019492 6677 SPAM1 http://www.ncbi.nlm.nih.gov/gene/?term=6677 "HEL-S-96n, HYA1, HYAL1, HYAL3, HYAL5, PH-20, PH20, SPAG15 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019493 66780 4933436I01Rik http://www.ncbi.nlm.nih.gov/gene/?term=66780 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019494 66781 4933437F24Rik http://www.ncbi.nlm.nih.gov/gene/?term=66781 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019495 6678 SPARC http://www.ncbi.nlm.nih.gov/gene/?term=6678 "BM-40, OI17, ON " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019496 6678 SPARC http://www.ncbi.nlm.nih.gov/gene/?term=6678 "BM-40, OI17, ON " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019497 667 DST http://www.ncbi.nlm.nih.gov/gene/?term=667 "BP240, BPA, BPAG1, CATX-15, CATX15, D6S1101, DMH, DT, EBSB2, HSAN6, MACF2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019498 667 DST http://www.ncbi.nlm.nih.gov/gene/?term=667 "BP240, BPA, BPAG1, CATX-15, CATX15, D6S1101, DMH, DT, EBSB2, HSAN6, MACF2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019499 66809 Krt20 http://www.ncbi.nlm.nih.gov/gene/?term=66809 "9030623C06Rik, Ck-20, Ck20, K20, Krt21 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019500 66816 Thap2 http://www.ncbi.nlm.nih.gov/gene/?term=66816 "2900040O07Rik, 9030625G08Rik, AI450385, AI649097 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019501 66821 Bcs1l http://www.ncbi.nlm.nih.gov/gene/?term=66821 9130022O19Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019502 66826 Taz http://www.ncbi.nlm.nih.gov/gene/?term=66826 "5031411C02Rik, 9130012G04Rik, AW107266, AW552613, G4.5 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019503 66832 Rsph3a http://www.ncbi.nlm.nih.gov/gene/?term=66832 "1700012G05Rik, 4930524H12Rik, R74860, Rshl2, Rshl2a " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019504 668343 Gm9115 http://www.ncbi.nlm.nih.gov/gene/?term=668343 EG668343 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019505 66836 Tmem223 http://www.ncbi.nlm.nih.gov/gene/?term=66836 0610006I08Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019506 66839 0610009O20Rik http://www.ncbi.nlm.nih.gov/gene/?term=66839 "2700004E22Rik, Dele, Kiaa0141 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019507 6683 SPAST http://www.ncbi.nlm.nih.gov/gene/?term=6683 "ADPSP, FSP2, SPG4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019508 6683 SPAST http://www.ncbi.nlm.nih.gov/gene/?term=6683 "ADPSP, FSP2, SPG4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019509 668408 1700084K02Rik http://www.ncbi.nlm.nih.gov/gene/?term=668408 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019510 66848 Fuca2 http://www.ncbi.nlm.nih.gov/gene/?term=66848 "0610025O11Rik, 5530401P20Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019511 66857 Plbd1 http://www.ncbi.nlm.nih.gov/gene/?term=66857 1100001H23Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019512 66857 Plbd1 http://www.ncbi.nlm.nih.gov/gene/?term=66857 1100001H23Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019513 66866 Nhlrc2 http://www.ncbi.nlm.nih.gov/gene/?term=66866 "1200003G01Rik, AI835049, AV002846, AW496455 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019514 66867 Hmg20a http://www.ncbi.nlm.nih.gov/gene/?term=66867 "1200004E06Rik, 5730490E10Rik, Hmgxb1, Ibraf " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019515 66869 Zfp869 http://www.ncbi.nlm.nih.gov/gene/?term=66869 1200003I07Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019516 66870 Serbp1 http://www.ncbi.nlm.nih.gov/gene/?term=66870 "1200009K13Rik, 9330147J08Rik, AL022786, Pairbp1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019517 66874 Ncbp3 http://www.ncbi.nlm.nih.gov/gene/?term=66874 "1200014J11Rik, C130061O14Rik, C78393 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019518 66875 Swt1 http://www.ncbi.nlm.nih.gov/gene/?term=66875 "1200016B10Rik, C1orf26 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019519 668771 Gm9347 http://www.ncbi.nlm.nih.gov/gene/?term=668771 EG668771 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019520 66877 Crnkl1 http://www.ncbi.nlm.nih.gov/gene/?term=66877 "1200013P10Rik, 5730590A01Rik, C80326, crn " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019521 6687 SPG7 http://www.ncbi.nlm.nih.gov/gene/?term=6687 "CAR, CMAR, PGN, SPG5C " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019522 6687 SPG7 http://www.ncbi.nlm.nih.gov/gene/?term=6687 "CAR, CMAR, PGN, SPG5C " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019523 6687 SPG7 http://www.ncbi.nlm.nih.gov/gene/?term=6687 "CAR, CMAR, PGN, SPG5C " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019524 66880 Rsrc1 http://www.ncbi.nlm.nih.gov/gene/?term=66880 "1200013F24Rik, SRrp53 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019525 66881 Pcyox1 http://www.ncbi.nlm.nih.gov/gene/?term=66881 "1200015P13Rik, AI115532, AI448340, PCL1, Pcly " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019526 66884 Appbp2 http://www.ncbi.nlm.nih.gov/gene/?term=66884 "1300003O07Rik, AI465480, PAT1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019527 66885 Acadsb http://www.ncbi.nlm.nih.gov/gene/?term=66885 "1300003O09Rik, 2-MEBCAD, BB066609, SBCAD " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019528 66887 Lonp2 http://www.ncbi.nlm.nih.gov/gene/?term=66887 "1300002A08Rik, AU015403, Lonp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019529 6688 SPI1 http://www.ncbi.nlm.nih.gov/gene/?term=6688 "OF, PU.1, SFPI1, SPI-1, SPI-A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019530 668917 Zfp133-ps http://www.ncbi.nlm.nih.gov/gene/?term=668917 "OTTMUSG00000003825, Zfp133 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019531 66897 Naa16 http://www.ncbi.nlm.nih.gov/gene/?term=66897 "1300019C06Rik, Narg1l " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019532 66898 Baiap2l1 http://www.ncbi.nlm.nih.gov/gene/?term=66898 "1300006M19Rik, AI585895, IRTKS " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019533 66899 Fip1l1 http://www.ncbi.nlm.nih.gov/gene/?term=66899 "1300019H17Rik, Rje " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019534 6689 SPIB http://www.ncbi.nlm.nih.gov/gene/?term=6689 SPI-B mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019535 66905 Plin3 http://www.ncbi.nlm.nih.gov/gene/?term=66905 "1300012C15Rik, M6prbp1, Tip47 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019536 6690 SPINK1 http://www.ncbi.nlm.nih.gov/gene/?term=6690 "PCTT, PSTI, Spink3, TATI, TCP " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019537 66910 Tmem107 http://www.ncbi.nlm.nih.gov/gene/?term=66910 "1110004B13Rik, 2810049P21Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019538 66911 Nudt16l1 http://www.ncbi.nlm.nih.gov/gene/?term=66911 "1110001K21Rik, 5330437I08Rik, Sdos " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019539 66912 Bzw2 http://www.ncbi.nlm.nih.gov/gene/?term=66912 "1110001I24Rik, Bdm2, HSPC028 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019540 66917 Chordc1 http://www.ncbi.nlm.nih.gov/gene/?term=66917 "1110001O09Rik, AA409036, Chp-1, morgana " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019541 66921 Prpf38b http://www.ncbi.nlm.nih.gov/gene/?term=66921 "1110021E09Rik, AU018955 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019542 66923 Pbrm1 http://www.ncbi.nlm.nih.gov/gene/?term=66923 "2610016F04Rik, AI507524, BAF180, Pb1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019543 6692 SPINT1 http://www.ncbi.nlm.nih.gov/gene/?term=6692 "HAI, HAI1, MANSC2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019544 66934 Dsn1 http://www.ncbi.nlm.nih.gov/gene/?term=66934 "1700022L09Rik, AW552447 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019545 66942 Ddx18 http://www.ncbi.nlm.nih.gov/gene/?term=66942 2310005B10Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019546 66942 Ddx18 http://www.ncbi.nlm.nih.gov/gene/?term=66942 2310005B10Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019547 66945 Sdha http://www.ncbi.nlm.nih.gov/gene/?term=66945 "1500032O14Rik, 2310034D06Rik, 4921513A11, C81073, FP, SDH2, SDHF " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019548 66949 Trim59 http://www.ncbi.nlm.nih.gov/gene/?term=66949 "2310035M22Rik, 2700022F13Rik, Mrf1, TSBF1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019549 66950 Tmem206 http://www.ncbi.nlm.nih.gov/gene/?term=66950 "2310028N02Rik, AI118576 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019550 66950 Tmem206 http://www.ncbi.nlm.nih.gov/gene/?term=66950 "2310028N02Rik, AI118576 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019551 66960 Fam188a http://www.ncbi.nlm.nih.gov/gene/?term=66960 "1810041E18Rik, 2310047O13Rik, 5830410F13Rik, AI447827, AW111958 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019552 66961 Neat1 http://www.ncbi.nlm.nih.gov/gene/?term=66961 "2310043N10Rik, VINC " lncRNA Mus musculus 17270048 Nucleus Liver cell In situ hybridization "In both the BLK CL.4 cell line and mouse liver, both Neat1 and Neat2/Malat-1 were both more than ten-fold enriched in nuclear fractions (Table ?(Table1).1) " RLID00019553 66961 Neat1 http://www.ncbi.nlm.nih.gov/gene/?term=66961 "2310043N10Rik, VINC " lncRNA Mus musculus 22070123 Nucleus Kidney cell In situ hybridization "Here, we discuss the functions of a distinct group of vertebrate-specific lncRNAs, NEAT1/MENε/β/VINC, MALAT1/NEAT2, and Gomafu/RNCR2/MIAT, which accumulate abundantly within the nucleus as RNA components of specific nuclear bodies. " RLID00019554 66961 Neat1 http://www.ncbi.nlm.nih.gov/gene/?term=66961 "2310043N10Rik, VINC " lncRNA Mus musculus 22817891 Nucleus Bone marrow Macrophage Next-generation sequencing "Cluster 7, for example, contains abundant transcripts in the chromatin, with much lower transcript levels in the nucleoplasm and cytoplasm relative to the other clusters. This cluster is dominated by annotated and unannotated non-coding transcripts and miRNA precursors. (The analysis excluded transcripts shorter than 400 nucleotides and therefore excluded mature miRNAs and many miRNA precursors.) Some non-coding RNAs, such as Xist, are highly enriched in the chromatin because they function at this location (Figure S2). Examples of other non-coding RNAs in Cluster 7 are Neat1 and Malat1/Neat2 (Figure S2). Further mining of the data sets may provide insights into the subcellular locations at which many non-coding RNAs function. Cluster 7 also includes transcripts from constitutive protein-coding genes that may be highly unstable and therefore present at low levels in the cytoplasm (e.g. Leng8 in Figure S2). " RLID00019555 66961 Neat1 http://www.ncbi.nlm.nih.gov/gene/?term=66961 "2310043N10Rik, VINC " lncRNA Mus musculus 21170033 Nucleus Myoblast In situ hybridization|qRT-PCR "Using this system, we demonstrate that Menε/β ncRNAs are essential to initiate the de novo assembly of paraspeckles. These newly formed structures effectively harbor nuclear retained mRNAs confirming that they are bona fide functional paraspeckles. " RLID00019556 66961 Neat1 http://www.ncbi.nlm.nih.gov/gene/?term=66961 "2310043N10Rik, VINC " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019557 66961 Neat1 http://www.ncbi.nlm.nih.gov/gene/?term=66961 "2310043N10Rik, VINC " lncRNA Mus musculus 22718948 Nucleus Embryotem cell In situ hybridization|Northern blot|qRT-PCR "However, the cellular levels of another long, noncoding RNA--Neat1--which is an architectural component of nuclear bodies known as paraspeckles, were down-regulated in a particular set of tissues and cells lacking Malat1. " RLID00019558 66966 Trit1 http://www.ncbi.nlm.nih.gov/gene/?term=66966 "2310075G14Rik, AI314189, AI314635, AV099619, IPT, MOD5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019559 66972 Slc25a23 http://www.ncbi.nlm.nih.gov/gene/?term=66972 "2310067G05Rik, SCaMC-3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019560 66975 Trappc13 http://www.ncbi.nlm.nih.gov/gene/?term=66975 "2410002O22Rik, 2610524F24Rik, AI451892, AU017229 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019561 66977 Nuf2 http://www.ncbi.nlm.nih.gov/gene/?term=66977 "2410003C07Rik, AU044112, C85691, Cdca1, NUF2R " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019562 66978 Luc7l http://www.ncbi.nlm.nih.gov/gene/?term=66978 "1810045C04Rik, 2410018D03Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019563 6697 SPR http://www.ncbi.nlm.nih.gov/gene/?term=6697 SDR38C1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019564 66983 Zfp830 http://www.ncbi.nlm.nih.gov/gene/?term=66983 "2410003C20Rik, AV301118, AW048207, Ccdc16, Omcg1, Znf830 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019565 66985 Rassf7 http://www.ncbi.nlm.nih.gov/gene/?term=66985 "2400009B11Rik, AW210608 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019566 66990 Tmem134 http://www.ncbi.nlm.nih.gov/gene/?term=66990 "2410001H17Rik, AI463452 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019567 66993 Smarcd3 http://www.ncbi.nlm.nih.gov/gene/?term=66993 "1500001J14Rik, 2210409C08Rik, BAF60C " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019568 66997 Psmd12 http://www.ncbi.nlm.nih.gov/gene/?term=66997 "1500002F15Rik, AI480719, P55 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019569 66999 Med28 http://www.ncbi.nlm.nih.gov/gene/?term=66999 "1500003D12Rik, AI451633, AU045690, Eg1, FKSG20, magicin " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019570 669 BPGM http://www.ncbi.nlm.nih.gov/gene/?term=669 DPGM mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019571 669 BPGM http://www.ncbi.nlm.nih.gov/gene/?term=669 DPGM mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019572 67016 Tbc1d2b http://www.ncbi.nlm.nih.gov/gene/?term=67016 "1810061M12Rik, AI480956, AV021536, AV023399, AW491493, mKIAA1055 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019573 67017 Fam210b http://www.ncbi.nlm.nih.gov/gene/?term=67017 "2010011I20Rik, AI430961, AV108736 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019574 67019 Actr6 http://www.ncbi.nlm.nih.gov/gene/?term=67019 "2010200J04Rik, AU044443, Arp6, ArpX, CDA12 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019575 67025 Rpl11 http://www.ncbi.nlm.nih.gov/gene/?term=67025 2010203J19Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019576 67026 Thap4 http://www.ncbi.nlm.nih.gov/gene/?term=67026 2010320B01Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019577 6702 SPRR2C http://www.ncbi.nlm.nih.gov/gene/?term=6702 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019578 67031 Upf3a http://www.ncbi.nlm.nih.gov/gene/?term=67031 "2600001C03Rik, 4930546M19Rik, RENT3A, UPF3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019579 67035 Dnajb4 http://www.ncbi.nlm.nih.gov/gene/?term=67035 "1700029A20Rik, 2010306G19Rik, 5730460G06Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019580 67037 Pmf1 http://www.ncbi.nlm.nih.gov/gene/?term=67037 "2600009M07Rik, AL033286, AW060657 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019581 67039 Rbm25 http://www.ncbi.nlm.nih.gov/gene/?term=67039 "2600011C06Rik, 2610015J01Rik, A130095G20Rik, AI159652, AL023075, AU043498, RNPC7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019582 67039 Rbm25 http://www.ncbi.nlm.nih.gov/gene/?term=67039 "2600011C06Rik, 2610015J01Rik, A130095G20Rik, AI159652, AL023075, AU043498, RNPC7 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019583 67040 Ddx17 http://www.ncbi.nlm.nih.gov/gene/?term=67040 "2610007K22Rik, A430025E01Rik, AI047725, C80929, Gm926, p72 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019584 67041 Oxct1 http://www.ncbi.nlm.nih.gov/gene/?term=67041 "2610008O03Rik, Oxct, Oxct2a, Scot-s " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019585 67042 Ift27 http://www.ncbi.nlm.nih.gov/gene/?term=67042 "2600013G09Rik, Rabl4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019586 67043 Syap1 http://www.ncbi.nlm.nih.gov/gene/?term=67043 "2010110O17Rik, AW011796 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019587 67045 Riok2 http://www.ncbi.nlm.nih.gov/gene/?term=67045 "2010110K24Rik, 2410085M17Rik " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019588 67045 Riok2 http://www.ncbi.nlm.nih.gov/gene/?term=67045 "2010110K24Rik, 2410085M17Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019589 67046 Tbc1d7 http://www.ncbi.nlm.nih.gov/gene/?term=67046 2610009C09Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019590 67049 Pus3 http://www.ncbi.nlm.nih.gov/gene/?term=67049 "2610020J05Rik, 5730412F04Rik " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019591 67049 Pus3 http://www.ncbi.nlm.nih.gov/gene/?term=67049 "2610020J05Rik, 5730412F04Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019592 67050 Nkap http://www.ncbi.nlm.nih.gov/gene/?term=67050 "2610020O08Rik, AA987160, AI849147, AL024236 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019593 67062 Slc25a53 http://www.ncbi.nlm.nih.gov/gene/?term=67062 "2310046F18Rik, 2810402A17Rik, AI448995, AI841128, Mcart6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019594 67062 Slc25a53 http://www.ncbi.nlm.nih.gov/gene/?term=67062 "2310046F18Rik, 2810402A17Rik, AI448995, AI841128, Mcart6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019595 6706 SPRR2G http://www.ncbi.nlm.nih.gov/gene/?term=6706 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019596 67070 Lsm14a http://www.ncbi.nlm.nih.gov/gene/?term=67070 "2700023B17Rik, AA407828, AU017544, Tral " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019597 67072 Cdc37l1 http://www.ncbi.nlm.nih.gov/gene/?term=67072 "2700033A15Rik, BB159850, Cdc37l, Harc " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019598 67073 Pi4k2b http://www.ncbi.nlm.nih.gov/gene/?term=67073 "2610042N09Rik, 4933409G22Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019599 67074 Mon2 http://www.ncbi.nlm.nih.gov/gene/?term=67074 "2610528O22Rik, AW495628, Sf21, mKIAA1040 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019600 67075 Magt1 http://www.ncbi.nlm.nih.gov/gene/?term=67075 "2410001C15Rik, 2610529C04Rik, 2810482I07Rik, IAG2, IAP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019601 67089 Psmc6 http://www.ncbi.nlm.nih.gov/gene/?term=67089 "2300001E01Rik, AI451058 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019602 6708 SPTA1 http://www.ncbi.nlm.nih.gov/gene/?term=6708 "EL2, HPP, HS3, SPH3, SPTA " mRNA Homo sapiens 10487838 Dendrite Brain In situ hybridization "In addition, hybridization of [alpha]-spectrin mRNA in 10-day-old animals appeared as grain alignments along the dendritic shafts. " RLID00019603 6708 SPTA1 http://www.ncbi.nlm.nih.gov/gene/?term=6708 "EL2, HPP, HS3, SPH3, SPTA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019604 67091 Trappc6a http://www.ncbi.nlm.nih.gov/gene/?term=67091 "1810073E21Rik, 4930519D19Rik, AI480686, TRS33, mhyp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019605 67097 Rps10 http://www.ncbi.nlm.nih.gov/gene/?term=67097 2210402A09Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019606 6709 SPTAN1 http://www.ncbi.nlm.nih.gov/gene/?term=6709 "EIEE5, NEAS, SPTA2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019607 6709 SPTAN1 http://www.ncbi.nlm.nih.gov/gene/?term=6709 "EIEE5, NEAS, SPTA2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019608 6709 SPTAN1 http://www.ncbi.nlm.nih.gov/gene/?term=6709 "EIEE5, NEAS, SPTA2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019609 670 BPHL http://www.ncbi.nlm.nih.gov/gene/?term=670 "BPH-RP, MCNAA, VACVASE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019610 670 BPHL http://www.ncbi.nlm.nih.gov/gene/?term=670 "BPH-RP, MCNAA, VACVASE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019611 67102 D16Ertd472e http://www.ncbi.nlm.nih.gov/gene/?term=67102 "1700010I10Rik, 2310009O17Rik, E330003K22Rik, Eurl " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019612 67102 D16Ertd472e http://www.ncbi.nlm.nih.gov/gene/?term=67102 "1700010I10Rik, 2310009O17Rik, E330003K22Rik, Eurl " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019613 67105 Timm21 http://www.ncbi.nlm.nih.gov/gene/?term=67105 "1700034H14Rik, 2700002I20Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019614 67106 Zbtb8os http://www.ncbi.nlm.nih.gov/gene/?term=67106 "2010001H09Rik, 2310028N13Rik, AI851226, Arch, Archm " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019615 67109 Zfp787 http://www.ncbi.nlm.nih.gov/gene/?term=67109 "2210018M03Rik, Znf787 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019616 67111 Naaa http://www.ncbi.nlm.nih.gov/gene/?term=67111 "2210023K21Rik, 3830414F09Rik, Asahl " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019617 67111 Naaa http://www.ncbi.nlm.nih.gov/gene/?term=67111 "2210023K21Rik, 3830414F09Rik, Asahl " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019618 67115 Rpl14 http://www.ncbi.nlm.nih.gov/gene/?term=67115 "3100001N19Rik, AA407502, AL022816, CAG-ISL-7, CTG-B33, L14 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019619 67117 Dynlt3 http://www.ncbi.nlm.nih.gov/gene/?term=67117 "2310075M16Rik, AU042796, Tcte1l " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019620 67117 Dynlt3 http://www.ncbi.nlm.nih.gov/gene/?term=67117 "2310075M16Rik, AU042796, Tcte1l " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019621 67117 Dynlt3 http://www.ncbi.nlm.nih.gov/gene/?term=67117 "2310075M16Rik, AU042796, Tcte1l " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00019622 67118 Bfar http://www.ncbi.nlm.nih.gov/gene/?term=67118 "3010001A07Rik, AI666707, AW107665, Bar, Rnf47 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019623 6711 SPTBN1 http://www.ncbi.nlm.nih.gov/gene/?term=6711 "ELF, HEL102, SPTB2, betaSpII " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019624 6711 SPTBN1 http://www.ncbi.nlm.nih.gov/gene/?term=6711 "ELF, HEL102, SPTB2, betaSpII " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019625 6711 SPTBN1 http://www.ncbi.nlm.nih.gov/gene/?term=6711 "ELF, HEL102, SPTB2, betaSpII " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019626 67120 Ttc14 http://www.ncbi.nlm.nih.gov/gene/?term=67120 "2700016E08Rik, 4930434D01Rik, 4931403I22Rik, 4933402I15Rik, AI662468, AU014779, AW561908, cI-44, mKIAA1980 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019627 67121 Mastl http://www.ncbi.nlm.nih.gov/gene/?term=67121 "2700091H24Rik, C88295, GW, GWL, MAST-L, THC2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019628 67126 Atp5e http://www.ncbi.nlm.nih.gov/gene/?term=67126 "2410043G19Rik, ATPE, AV000645 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00019629 6712 SPTBN2 http://www.ncbi.nlm.nih.gov/gene/?term=6712 "GTRAP41, SCA5, SCAR14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019630 67134 Nop56 http://www.ncbi.nlm.nih.gov/gene/?term=67134 "2310044F10Rik, Nol5a " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019631 67138 Herc6 http://www.ncbi.nlm.nih.gov/gene/?term=67138 "1700121D12Rik, 2510038N07Rik, 4930427L17Rik, AI451296, CEB1, Herc5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019632 6713 SQLE http://www.ncbi.nlm.nih.gov/gene/?term=6713 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019633 6713 SQLE http://www.ncbi.nlm.nih.gov/gene/?term=6713 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019634 6713 SQLE http://www.ncbi.nlm.nih.gov/gene/?term=6713 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019635 67141 Fbxo5 http://www.ncbi.nlm.nih.gov/gene/?term=67141 "2510044I10Rik, C85305, Emi1, Fbxo31 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019636 67144 Lrrc40 http://www.ncbi.nlm.nih.gov/gene/?term=67144 "2610040E16Rik, AI837674 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019637 67145 Tomm34 http://www.ncbi.nlm.nih.gov/gene/?term=67145 "2610100K07Rik, TOM34 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019638 6714 SRC http://www.ncbi.nlm.nih.gov/gene/?term=6714 "ASV1, c-SRC, p60-Src, SRC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019639 67151 Psmd9 http://www.ncbi.nlm.nih.gov/gene/?term=67151 "1500011J20Rik, 2610202L11Rik, Bridge-1, P27 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019640 671535 Parp10 http://www.ncbi.nlm.nih.gov/gene/?term=671535 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019641 67155 Smarca2 http://www.ncbi.nlm.nih.gov/gene/?term=67155 "2610209L14Rik, SNF2alpha, Snf2l2, brahma, brm " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019642 6715 SRD5A1 http://www.ncbi.nlm.nih.gov/gene/?term=6715 S5AR 1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019643 6715 SRD5A1 http://www.ncbi.nlm.nih.gov/gene/?term=6715 S5AR 1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019644 6715 SRD5A1 http://www.ncbi.nlm.nih.gov/gene/?term=6715 S5AR 1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019645 67161 Sclt1 http://www.ncbi.nlm.nih.gov/gene/?term=67161 "2610207F23Rik, 4931421F20Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019646 67163 Ccdc47 http://www.ncbi.nlm.nih.gov/gene/?term=67163 "2610204L23Rik, C88307, asp4, calumin " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019647 67166 Arl8b http://www.ncbi.nlm.nih.gov/gene/?term=67166 "2610313E07Rik, 3100002J04Rik, Arl10c, gie1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019648 67168 Lpar6 http://www.ncbi.nlm.nih.gov/gene/?term=67168 "2610302I02Rik, P2ry5, P2y5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019649 67168 Lpar6 http://www.ncbi.nlm.nih.gov/gene/?term=67168 "2610302I02Rik, P2ry5, P2y5 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019650 67178 Zmat5 http://www.ncbi.nlm.nih.gov/gene/?term=67178 "2610510L01Rik, D11Bwg0572e, D11Bwg1548e " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019651 6717 SRI http://www.ncbi.nlm.nih.gov/gene/?term=6717 "CP-22, CP22, SCN, V19 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019652 6717 SRI http://www.ncbi.nlm.nih.gov/gene/?term=6717 "CP-22, CP22, SCN, V19 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019653 6717 SRI http://www.ncbi.nlm.nih.gov/gene/?term=6717 "CP-22, CP22, SCN, V19 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019654 67186 Rplp2 http://www.ncbi.nlm.nih.gov/gene/?term=67186 2700049I22Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019655 67194 2700038G22Rik http://www.ncbi.nlm.nih.gov/gene/?term=67194 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019656 67198 Spats2l http://www.ncbi.nlm.nih.gov/gene/?term=67198 "2810022L02Rik, A230104H11Rik, AA987173, AI480531, AI842453, AW413586 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019657 67198 Spats2l http://www.ncbi.nlm.nih.gov/gene/?term=67198 "2810022L02Rik, A230104H11Rik, AA987173, AI480531, AI842453, AW413586 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019658 67199 Pfdn1 http://www.ncbi.nlm.nih.gov/gene/?term=67199 "2700086I23Rik, AA408327, AU044714 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00019659 67200 Ccdc77 http://www.ncbi.nlm.nih.gov/gene/?term=67200 "2400002C23Rik, 2700091N06Rik, AV168274 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019660 67201 Glod4 http://www.ncbi.nlm.nih.gov/gene/?term=67201 "1700082G03Rik, 2700085E05Rik, C81254 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00019661 67204 Eif2s2 http://www.ncbi.nlm.nih.gov/gene/?term=67204 "2810026E11Rik, 38kDa, AA408636, AA571381, AA986487, AW822225, D2Ertd303e, EIF2, EIF2B " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019662 67204 Eif2s2 http://www.ncbi.nlm.nih.gov/gene/?term=67204 "2810026E11Rik, 38kDa, AA408636, AA571381, AA986487, AW822225, D2Ertd303e, EIF2, EIF2B " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00019663 6720 SREBF1 http://www.ncbi.nlm.nih.gov/gene/?term=6720 "SREBP-1c, SREBP1, SREBP1a, bHLHd1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019664 6720 SREBF1 http://www.ncbi.nlm.nih.gov/gene/?term=6720 "SREBP-1c, SREBP1, SREBP1a, bHLHd1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019665 67211 Armc10 http://www.ncbi.nlm.nih.gov/gene/?term=67211 "2810037C14Rik, Svh " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019666 6721 SREBF2 http://www.ncbi.nlm.nih.gov/gene/?term=6721 "SREBP-2, SREBP2, bHLHd2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019667 6721 SREBF2 http://www.ncbi.nlm.nih.gov/gene/?term=6721 "SREBP-2, SREBP2, bHLHd2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019668 67220 Plekho1 http://www.ncbi.nlm.nih.gov/gene/?term=67220 "2810052M02Rik, CKIP-1, Ckip1, JZA-20, Jza2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019669 67225 Rnpc3 http://www.ncbi.nlm.nih.gov/gene/?term=67225 "2810441O16Rik, AI447568, C030014B17Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019670 67229 Prpf18 http://www.ncbi.nlm.nih.gov/gene/?term=67229 2810441A10Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019671 6722 SRF http://www.ncbi.nlm.nih.gov/gene/?term=6722 MCM1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019672 6722 SRF http://www.ncbi.nlm.nih.gov/gene/?term=6722 MCM1 mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00019673 6722 SRF http://www.ncbi.nlm.nih.gov/gene/?term=6722 MCM1 mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00019674 67231 Tbc1d20 http://www.ncbi.nlm.nih.gov/gene/?term=67231 "1110028I04Rik, 2810442O16Rik, AI414693, bs " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019675 67236 Cinp http://www.ncbi.nlm.nih.gov/gene/?term=67236 "1810047K05Rik, 2810452K22Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019676 67239 Rpf2 http://www.ncbi.nlm.nih.gov/gene/?term=67239 "2810470K21Rik, AU040229, AU043242, Bxdc1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019677 6723 SRM http://www.ncbi.nlm.nih.gov/gene/?term=6723 "PAPT, SPDSY, SPS1L1, SRM " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019678 6723 SRM http://www.ncbi.nlm.nih.gov/gene/?term=6723 "PAPT, SPDSY, SPS1, SRML1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019679 67241 Smc6 http://www.ncbi.nlm.nih.gov/gene/?term=67241 "2810489L22Rik, 3830418C19Rik, AA990493, AU018782, AW742439, SMC-6l1, mKIAA4103, Smc6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019680 67245 Peli1 http://www.ncbi.nlm.nih.gov/gene/?term=67245 "2810468L03Rik, A930031K15Rik, AA409794, AI586297, D11Ertd676e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019681 67246 2810474O19Rik http://www.ncbi.nlm.nih.gov/gene/?term=67246 "6720435I21Rik, AA536804, AU020969, GET, Kiaa1551 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019682 67246 2810474O19Rik http://www.ncbi.nlm.nih.gov/gene/?term=67246 "6720435I21Rik, AA536804, AU020969, GET, Kiaa1551 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019683 67248 Rpl39 http://www.ncbi.nlm.nih.gov/gene/?term=67248 2810465O16Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019684 67248 Rpl39 http://www.ncbi.nlm.nih.gov/gene/?term=67248 2810465O16Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019685 67249 Tbc1d19 http://www.ncbi.nlm.nih.gov/gene/?term=67249 2810453K03Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019686 672511 Rnf213 http://www.ncbi.nlm.nih.gov/gene/?term=672511 "6030403J01, D11Ertd759e, mKIAA1554 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019687 6725 SRMS http://www.ncbi.nlm.nih.gov/gene/?term=6725 "C20orf148, SRM, dJ697K14.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019688 67263 Zswim6 http://www.ncbi.nlm.nih.gov/gene/?term=67263 "2900036G02Rik, mKIAA1577 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019689 67264 Ndufb8 http://www.ncbi.nlm.nih.gov/gene/?term=67264 "2900010I05Rik, AI987932 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019690 67266 Fam69a http://www.ncbi.nlm.nih.gov/gene/?term=67266 "2900024C23Rik, AI315274 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019691 67266 Fam69a http://www.ncbi.nlm.nih.gov/gene/?term=67266 "2900024C23Rik, AI315274 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019692 6726 SRP9 http://www.ncbi.nlm.nih.gov/gene/?term=6726 ALURBP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019693 6727 SRP14 http://www.ncbi.nlm.nih.gov/gene/?term=6727 ALURBP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019694 67281 Rpl37 http://www.ncbi.nlm.nih.gov/gene/?term=67281 3110005M08Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019695 67282 Ccdc53 http://www.ncbi.nlm.nih.gov/gene/?term=67282 "2900091E11Rik, 5730495F03Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019696 67283 Slc25a19 http://www.ncbi.nlm.nih.gov/gene/?term=67283 "2900089E13Rik, DNC, MUP1, TPC " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019697 67285 Cwc27 http://www.ncbi.nlm.nih.gov/gene/?term=67285 "3110009E13Rik, NY-CO-10, Sdccag10 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019698 67286 Ift22 http://www.ncbi.nlm.nih.gov/gene/?term=67286 "3110017O03Rik, AI835745, AI847427, Rabl5 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019699 67288 Srek1ip1 http://www.ncbi.nlm.nih.gov/gene/?term=67288 "3110031B13Rik, AI462702, AV348305, AW121048, Sfrs12ip1, Srsf12ip1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019700 67289 3110021A11Rik http://www.ncbi.nlm.nih.gov/gene/?term=67289 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019701 6728 SRP19 http://www.ncbi.nlm.nih.gov/gene/?term=6728 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019702 6728 SRP19 http://www.ncbi.nlm.nih.gov/gene/?term=6728 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019703 6728 SRP19 http://www.ncbi.nlm.nih.gov/gene/?term=6728 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019704 67291 Ccdc137 http://www.ncbi.nlm.nih.gov/gene/?term=67291 3110023B02Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019705 67292 Pigc http://www.ncbi.nlm.nih.gov/gene/?term=67292 "3110030E07Rik, AW212108 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019706 67295 Rab3c http://www.ncbi.nlm.nih.gov/gene/?term=67295 "2700062I01Rik, 3110015B08Rik, 3110037E15Rik, AI850886 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019707 67298 Gprasp1 http://www.ncbi.nlm.nih.gov/gene/?term=67298 "2210415K24Rik, 3110031O14Rik, C87852, GASP, GASP1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019708 67299 Dock7 http://www.ncbi.nlm.nih.gov/gene/?term=67299 "3110056M06Rik, Gm430, m " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019709 6729 SRP54 http://www.ncbi.nlm.nih.gov/gene/?term=6729 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019710 6729 SRP54 http://www.ncbi.nlm.nih.gov/gene/?term=6729 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019711 672 BRCA1 http://www.ncbi.nlm.nih.gov/gene/?term=672 "BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019712 672 BRCA1 http://www.ncbi.nlm.nih.gov/gene/?term=672 "BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019713 672 BRCA1 http://www.ncbi.nlm.nih.gov/gene/?term=672 "BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019714 67300 Cltc http://www.ncbi.nlm.nih.gov/gene/?term=67300 "3110065L21Rik, CHC, R74732 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019715 67302 Zc3h13 http://www.ncbi.nlm.nih.gov/gene/?term=67302 "2600010B19Rik, 3110050K21Rik, 4930570G11Rik, C87618 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019716 67306 Zc2hc1a http://www.ncbi.nlm.nih.gov/gene/?term=67306 "3110050N22Rik, AI790358, AU023959, Fam164a " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019717 6730 SRP68 http://www.ncbi.nlm.nih.gov/gene/?term=6730 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019718 6730 SRP68 http://www.ncbi.nlm.nih.gov/gene/?term=6730 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019719 6730 SRP68 http://www.ncbi.nlm.nih.gov/gene/?term=6730 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019720 67315 Ceacam12 http://www.ncbi.nlm.nih.gov/gene/?term=67315 "1600031J20Rik-C1, Ceacam12-C3, Ceacam12C1, Ceacam12C3, Ceacam12 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019721 6731 SRP72 http://www.ncbi.nlm.nih.gov/gene/?term=6731 "BMFF, BMFS1, HEL103 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019722 6731 SRP72 http://www.ncbi.nlm.nih.gov/gene/?term=6731 "BMFF, BMFS1, HEL103 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019723 6731 SRP72 http://www.ncbi.nlm.nih.gov/gene/?term=6731 "BMFF, BMFS1, HEL103 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019724 67326 1700037H04Rik http://www.ncbi.nlm.nih.gov/gene/?term=67326 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019725 6732 SRPK1 http://www.ncbi.nlm.nih.gov/gene/?term=6732 SFRSK1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019726 6732 SRPK1 http://www.ncbi.nlm.nih.gov/gene/?term=6732 SFRSK1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019727 67337 Cstf1 http://www.ncbi.nlm.nih.gov/gene/?term=67337 "1700057K18Rik, AI788832 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019728 6733 SRPK2 http://www.ncbi.nlm.nih.gov/gene/?term=6733 SFRSK2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019729 6733 SRPK2 http://www.ncbi.nlm.nih.gov/gene/?term=6733 SFRSK2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019730 67344 Tctex1d1 http://www.ncbi.nlm.nih.gov/gene/?term=67344 1700055O19Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019731 67345 Herc4 http://www.ncbi.nlm.nih.gov/gene/?term=67345 "1700056O17Rik, 4921531D01Rik, 9530080M15Rik, mKIAA1593 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019732 6734 SRPRA http://www.ncbi.nlm.nih.gov/gene/?term=6734 "DP, SRPR, Sralpha " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019733 6734 SRPRA http://www.ncbi.nlm.nih.gov/gene/?term=6734 "DP, SRPR, Sralpha " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019734 67367 Paxbp1 http://www.ncbi.nlm.nih.gov/gene/?term=67367 "1810007M14Rik, C21orf66, Gcfc, Gcfc1, Pax3/7bp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019735 67371 Gtf3c6 http://www.ncbi.nlm.nih.gov/gene/?term=67371 "2410016F19Rik, AU019813 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019736 67379 Dedd2 http://www.ncbi.nlm.nih.gov/gene/?term=67379 "2410050E11Rik, FLAME-3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019737 67382 Brd3 http://www.ncbi.nlm.nih.gov/gene/?term=67382 "2410084F24Rik, AW060456, Fsrg2, ORFX, RINGL3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019738 67387 Unc50 http://www.ncbi.nlm.nih.gov/gene/?term=67387 "1110002A21Rik, GMH1, UNCL, URP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019739 6738 TROVE2 http://www.ncbi.nlm.nih.gov/gene/?term=6738 "RO60, RORNP, SSA2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019740 6738 TROVE2 http://www.ncbi.nlm.nih.gov/gene/?term=6738 "RO60, RORNP, SSA2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019741 6738 TROVE2 http://www.ncbi.nlm.nih.gov/gene/?term=6738 "RO60, RORNP, SSA2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019742 67392 4833420G17Rik http://www.ncbi.nlm.nih.gov/gene/?term=67392 "2210017J06Rik, 5730533D17Rik, AW107518, C85193 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019743 67392 4833420G17Rik http://www.ncbi.nlm.nih.gov/gene/?term=67392 "2210017J06Rik, 5730533D17Rik, AW107518, C85193 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019744 67394 4930404I05Rik http://www.ncbi.nlm.nih.gov/gene/?term=67394 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019745 673 BRAF http://www.ncbi.nlm.nih.gov/gene/?term=673 "B-RAF11, NS7, RAFB1, BRAF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019746 673 BRAF http://www.ncbi.nlm.nih.gov/gene/?term=673 "B-RAF1, BRAF1, NS7, RAFB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019747 67414 Mfn1 http://www.ncbi.nlm.nih.gov/gene/?term=67414 "2310002F04Rik, 6330416C07Rik, D3Ertd265e, HR2, mKIAA4032 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019748 67418 Ppil4 http://www.ncbi.nlm.nih.gov/gene/?term=67418 "3732410E19Rik, 3830425H19Rik, AI788954, AW146233, PPIase " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019749 67419 3632451O06Rik http://www.ncbi.nlm.nih.gov/gene/?term=67419 AU067705 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019750 6741 SSB http://www.ncbi.nlm.nih.gov/gene/?term=6741 "LARP3, La, La/SSB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019751 6741 SSB http://www.ncbi.nlm.nih.gov/gene/?term=6741 "LARP3, La, La/SSB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019752 67420 Far1 http://www.ncbi.nlm.nih.gov/gene/?term=67420 "2600011M19Rik, 2900034E22Rik, 3732409C05Rik, AI850429, Mlstd2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019753 67422 Dhdds http://www.ncbi.nlm.nih.gov/gene/?term=67422 "3222401G21Rik, CIT, DS, HDS, W91638 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019754 67427 Rps20 http://www.ncbi.nlm.nih.gov/gene/?term=67427 "4632426K06Rik, Dsk4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019755 6742 SSBP1 http://www.ncbi.nlm.nih.gov/gene/?term=6742 "Mt-SSB, SOSS-B1, SSBP, mtSSB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019756 6742 SSBP1 http://www.ncbi.nlm.nih.gov/gene/?term=6742 "Mt-SSB, SOSS-B1, SSBP, mtSSB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019757 67437 Ssr3 http://www.ncbi.nlm.nih.gov/gene/?term=67437 "0610038P07Rik, AL022999, AU022074, AW553833, TRAPG " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019758 67440 Mtpap http://www.ncbi.nlm.nih.gov/gene/?term=67440 "0610027A18Rik, AW551379, Papd1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019759 67446 Dusp28 http://www.ncbi.nlm.nih.gov/gene/?term=67446 "0710001B24Rik, AV005521 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019760 6744 SSFA2 http://www.ncbi.nlm.nih.gov/gene/?term=6744 "CS-1, CS1, KRAP, SPAG13 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019761 6744 SSFA2 http://www.ncbi.nlm.nih.gov/gene/?term=6744 "CS-1, CS1, KRAP, SPAG13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019762 67452 Pnpla8 http://www.ncbi.nlm.nih.gov/gene/?term=67452 "1200006O19Rik, AI467579, Ipla2(gamma) " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019763 67453 Slc25a46 http://www.ncbi.nlm.nih.gov/gene/?term=67453 "1200007B05Rik, AI325987 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019764 67454 Ikbip http://www.ncbi.nlm.nih.gov/gene/?term=67454 "1200009F10Rik, 1700023M03Rik, D18354, Ikip " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019765 67457 Frmd8 http://www.ncbi.nlm.nih.gov/gene/?term=67457 "1200004M23Rik, 2310035N23Rik, 4931429L16Rik, AU018809 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019766 67459 Nvl http://www.ncbi.nlm.nih.gov/gene/?term=67459 1200009I24Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019767 6745 SSR1 http://www.ncbi.nlm.nih.gov/gene/?term=6745 TRAPA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019768 6745 SSR1 http://www.ncbi.nlm.nih.gov/gene/?term=6745 TRAPA mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019769 6745 SSR1 http://www.ncbi.nlm.nih.gov/gene/?term=6745 TRAPA mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019770 6745 SSR1 http://www.ncbi.nlm.nih.gov/gene/?term=6745 TRAPA mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019771 6745 SSR1 http://www.ncbi.nlm.nih.gov/gene/?term=6745 TRAPA mRNA Homo sapiens 22679391 Endoplasmic reticulum U2OS cell RT-PCR "Figure 3B: The levels of several transcripts in the ER fraction were analyzed as in (A). Measured transcripts include those encoding ER luminal proteins (BiP, Calreticulin), ER membrane proteins (Inositol-3-phosphate Receptor (IP3 Receptor), Sec61α, Trapα, and Fatty Acid Desaturase 3 (FADS3)), a Golgi protein (Mannosidase 2A (Man2A)), plasma membrane proteins (Integrin β1, and Transferrin Receptor (Tf Receptor)), and a secreted protein (Interleukin 7 (IL7)). All measurements were standardized to the level of mRNA in the ER fraction from control cells. Data are collected from Figure 3B. " RLID00019772 6745 SSR1 http://www.ncbi.nlm.nih.gov/gene/?term=6745 TRAPA mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019773 67466 Pdcl http://www.ncbi.nlm.nih.gov/gene/?term=67466 "1200011E13Rik, AW108059, PhLP1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019774 67467 Gpalpp1 http://www.ncbi.nlm.nih.gov/gene/?term=67467 "1200011I18Rik, Kiaa1704 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019775 67468 Mmd http://www.ncbi.nlm.nih.gov/gene/?term=67468 "1200017E07Rik, 1810073C06Rik, AA690185 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019776 6746 SSR2 http://www.ncbi.nlm.nih.gov/gene/?term=6746 "HSD25, TLAP, TRAP-BETA, TRAPB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019777 6746 SSR2 http://www.ncbi.nlm.nih.gov/gene/?term=6746 "HSD25, TLAP, TRAP-BETA, TRAPB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019778 67471 Gpatch1 http://www.ncbi.nlm.nih.gov/gene/?term=67471 "1300003A17Rik, ECGP, Gpatc1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019779 67474 Snap29 http://www.ncbi.nlm.nih.gov/gene/?term=67474 "1300018G05Rik, AI891940, AU020222, BB131856, Gs32 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019780 6747 SSR3 http://www.ncbi.nlm.nih.gov/gene/?term=6747 TRAPG mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019781 6747 SSR3 http://www.ncbi.nlm.nih.gov/gene/?term=6747 TRAPG mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019782 6747 SSR3 http://www.ncbi.nlm.nih.gov/gene/?term=6747 TRAPG mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019783 67480 Cwc25 http://www.ncbi.nlm.nih.gov/gene/?term=67480 "1300013D05Rik, AA473636, Ccdc49, R75228 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019784 67486 Polr3g http://www.ncbi.nlm.nih.gov/gene/?term=67486 "2310047G20Rik, AV275904, RPC32, RPC7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019785 67487 Dhx40 http://www.ncbi.nlm.nih.gov/gene/?term=67487 "2410016C14Rik, ARG147, DDX40, PAD " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019786 6748 SSR4 http://www.ncbi.nlm.nih.gov/gene/?term=6748 "CDG1Y, TRAPD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019787 6748 SSR4 http://www.ncbi.nlm.nih.gov/gene/?term=6748 "CDG1Y, TRAPD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019788 67490 Ufl1 http://www.ncbi.nlm.nih.gov/gene/?term=67490 "1810074P20Rik, AI429228, Kiaa0776, Maxer, Rcad, mKIAA0776 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019789 6749 SSRP1 http://www.ncbi.nlm.nih.gov/gene/?term=6749 "FACT, FACT80, T160 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019790 6749 SSRP1 http://www.ncbi.nlm.nih.gov/gene/?term=6749 "FACT, FACT80, T160 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019791 6749 SSRP1 http://www.ncbi.nlm.nih.gov/gene/?term=6749 "FACT, FACT80, T160 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019792 67501 Ccdc50 http://www.ncbi.nlm.nih.gov/gene/?term=67501 C3orf6 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019793 67510 Tvp23b http://www.ncbi.nlm.nih.gov/gene/?term=67510 "1810036I24Rik, Fam18b, Fam18b1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019794 67510 Tvp23b http://www.ncbi.nlm.nih.gov/gene/?term=67510 "1810036I24Rik, Fam18b, Fam18b1 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00019795 67511 Tmed9 http://www.ncbi.nlm.nih.gov/gene/?term=67511 2400003B06Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019796 67515 Ttc33 http://www.ncbi.nlm.nih.gov/gene/?term=67515 "2410099M07Rik, 2900001O04Rik, AI507072, AW538342, Osrf " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019797 67516 Kctd4 http://www.ncbi.nlm.nih.gov/gene/?term=67516 "2210017A09Rik, AU017169 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019798 67524 1700095A21Rik http://www.ncbi.nlm.nih.gov/gene/?term=67524 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019799 67528 Nudt7 http://www.ncbi.nlm.nih.gov/gene/?term=67528 "1300007B24Rik, 2210404C19Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019800 67529 Fgfr1op2 http://www.ncbi.nlm.nih.gov/gene/?term=67529 1500031J01Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019801 67531 5730408K05Rik http://www.ncbi.nlm.nih.gov/gene/?term=67531 2610018C13Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019802 67532 Mfap1a http://www.ncbi.nlm.nih.gov/gene/?term=67532 "4432409M24Rik, Mfap1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019803 67533 Ppfibp1 http://www.ncbi.nlm.nih.gov/gene/?term=67533 "4632409B19Rik, AW214454, AW261454 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019804 67533 Ppfibp1 http://www.ncbi.nlm.nih.gov/gene/?term=67533 "4632409B19Rik, AW214454, AW261454 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00019805 67534 Ttll4 http://www.ncbi.nlm.nih.gov/gene/?term=67534 "4632407P03Rik, AI451681, mKIAA0173 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019806 67552 H2afy3 http://www.ncbi.nlm.nih.gov/gene/?term=67552 4933432H23Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019807 67554 Slc25a30 http://www.ncbi.nlm.nih.gov/gene/?term=67554 "4933433D23Rik, AV025504, AV221431, AW319655, KMCP1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019808 67557 Larp6 http://www.ncbi.nlm.nih.gov/gene/?term=67557 "5430431G03Rik, AI552438, Achn " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019809 67561 Wdr48 http://www.ncbi.nlm.nih.gov/gene/?term=67561 "8430408H12Rik, Uaf1, mKIAA1449 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019810 67563 Narfl http://www.ncbi.nlm.nih.gov/gene/?term=67563 "9030612I22Rik, AI504405, PRN " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019811 67575 4930430A15Rik http://www.ncbi.nlm.nih.gov/gene/?term=67575 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019812 67580 Lrrc18 http://www.ncbi.nlm.nih.gov/gene/?term=67580 "4930442L21Rik, MTLR1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019813 675812 Zfp605 http://www.ncbi.nlm.nih.gov/gene/?term=675812 A830023I12Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019814 67581 Tbc1d23 http://www.ncbi.nlm.nih.gov/gene/?term=67581 "4930451A13Rik, AU015720, AU043671, AU043778, D030022P07Rik, W51689 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019815 67588 Rnf41 http://www.ncbi.nlm.nih.gov/gene/?term=67588 "2210404G21Rik, 4930511A05Rik, 4933415P08Rik, D10Ertd722e, FLRF, Nrdp1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019816 67589 4930518J20Rik http://www.ncbi.nlm.nih.gov/gene/?term=67589 AV209277 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019817 675 BRCA2 http://www.ncbi.nlm.nih.gov/gene/?term=675 "BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019818 675 BRCA2 http://www.ncbi.nlm.nih.gov/gene/?term=675 "BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019819 67605 Akt1s1 http://www.ncbi.nlm.nih.gov/gene/?term=67605 "1110012J22Rik, AI227026, Lobe, Lobel, PRAS40 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019820 6760 SS18 http://www.ncbi.nlm.nih.gov/gene/?term=6760 "SSXT, SYT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019821 6760 SS18 http://www.ncbi.nlm.nih.gov/gene/?term=6760 "SSXT, SYT " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019822 6760 SS18 http://www.ncbi.nlm.nih.gov/gene/?term=6760 "SSXT, SYT " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019823 6760 SS18 http://www.ncbi.nlm.nih.gov/gene/?term=6760 "SSXT, SYT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019824 67610 Rspry1 http://www.ncbi.nlm.nih.gov/gene/?term=67610 "4930470D19Rik, AI608258 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019825 67622 Mxra7 http://www.ncbi.nlm.nih.gov/gene/?term=67622 "1810057P16Rik, E130302J09Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019826 67629 Spc24 http://www.ncbi.nlm.nih.gov/gene/?term=67629 "2410030K01Rik, AV109292, Spbc24 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019827 67666 Hapln3 http://www.ncbi.nlm.nih.gov/gene/?term=67666 "4930554N11Rik, Lpr3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019828 67667 Alkbh8 http://www.ncbi.nlm.nih.gov/gene/?term=67667 "4930562C03Rik, 8030431D03Rik, 9430088N01Rik, Abh8 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019829 67668 4930563N14Rik http://www.ncbi.nlm.nih.gov/gene/?term=67668 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019830 67671 Rpl38 http://www.ncbi.nlm.nih.gov/gene/?term=67671 "0610025G13Rik, Rbt, Ts, Tss " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019831 67673 Tceb2 http://www.ncbi.nlm.nih.gov/gene/?term=67673 0610040H15Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019832 6767 ST13 http://www.ncbi.nlm.nih.gov/gene/?term=6767 "AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019833 6767 ST13 http://www.ncbi.nlm.nih.gov/gene/?term=6767 "AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019834 6767 ST13 http://www.ncbi.nlm.nih.gov/gene/?term=6767 "AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019835 67684 Luc7l3 http://www.ncbi.nlm.nih.gov/gene/?term=67684 "3300001P08Rik, Luc7a " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019836 67689 Aldh3b1 http://www.ncbi.nlm.nih.gov/gene/?term=67689 "1700001N19Rik, ALDH4, ALDH7 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019837 6768 ST14 http://www.ncbi.nlm.nih.gov/gene/?term=6768 "ARCI11, HAI, MT-SP1, MTSP1, PRSS14, SNC19, TADG15, TMPRSS14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019838 6768 ST14 http://www.ncbi.nlm.nih.gov/gene/?term=6768 "ARCI11, HAI, MT-SP1, MTSP1, PRSS14, SNC19, TADG15, TMPRSS14 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019839 67694 Ift74 http://www.ncbi.nlm.nih.gov/gene/?term=67694 "1700029H06Rik, Ccdc2, Cmg1, b2b796Clo " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019840 67702 Rnf149 http://www.ncbi.nlm.nih.gov/gene/?term=67702 "1600023E10Rik, AV037261, C76763, Gm15832, Greul4, OTTMUSG00000026591 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019841 67712 Slc25a37 http://www.ncbi.nlm.nih.gov/gene/?term=67712 "1700020E22Rik, 4930513O14Rik, 4930526G11Rik, AI848481, C330015G08Rik, Mfrn, Mfrn1, Mscp, frascati, mitoferrin " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019842 67723 Cep83os http://www.ncbi.nlm.nih.gov/gene/?term=67723 "4932415G12Rik, Ccdc41os1 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019843 67726 Fam114a2 http://www.ncbi.nlm.nih.gov/gene/?term=67726 "1810073G14Rik, 9030624B09Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019844 67727 Stx17 http://www.ncbi.nlm.nih.gov/gene/?term=67727 "4833418L03Rik, 6330411F21Rik, 9030425C21Rik, AW048351 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019845 6772 STAT1 http://www.ncbi.nlm.nih.gov/gene/?term=6772 "CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019846 6772 STAT1 http://www.ncbi.nlm.nih.gov/gene/?term=6772 "CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019847 6772 STAT1 http://www.ncbi.nlm.nih.gov/gene/?term=6772 "CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019848 6773 STAT2 http://www.ncbi.nlm.nih.gov/gene/?term=6773 "IMD44, ISGF-3, P113, STAT113 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019849 67741 4930579F01Rik http://www.ncbi.nlm.nih.gov/gene/?term=67741 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019850 6774 STAT3 http://www.ncbi.nlm.nih.gov/gene/?term=6774 "ADMIO, APRF, HIES " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019851 6774 STAT3 http://www.ncbi.nlm.nih.gov/gene/?term=6774 "ADMIO, APRF, HIES " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019852 6775 STAT4 http://www.ncbi.nlm.nih.gov/gene/?term=6775 SLEB11 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019853 67760 Slc38a2 http://www.ncbi.nlm.nih.gov/gene/?term=67760 "5033402L14Rik, AI316867, ATA2, SAT2, mKIAA1382 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019854 67763 Prpsap1 http://www.ncbi.nlm.nih.gov/gene/?term=67763 "5730409F23Rik, PAP39 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019855 677679 SCARNA3 http://www.ncbi.nlm.nih.gov/gene/?term=677679 HBI-100 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019856 677681 SCARNA20 http://www.ncbi.nlm.nih.gov/gene/?term=677681 ACA66 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019857 67769 Gpatch2 http://www.ncbi.nlm.nih.gov/gene/?term=67769 "5830433G22Rik, 5830436K05Rik, AI427714, AI447508, AW107440, AW491060, Gpatc2 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019858 67769 Gpatch2 http://www.ncbi.nlm.nih.gov/gene/?term=67769 "5830433G22Rik, 5830436K05Rik, AI427714, AI447508, AW107440, AW491060, Gpatc2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019859 6776 STAT5A http://www.ncbi.nlm.nih.gov/gene/?term=6776 "MGF, STAT5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019860 67772 Chd8 http://www.ncbi.nlm.nih.gov/gene/?term=67772 "5830451P18Rik, AU015341, Duplin, HELSNF1, mKIAA1564 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019861 67774 Borcs5 http://www.ncbi.nlm.nih.gov/gene/?term=67774 "5830457J20Rik, AW124643, Loh12cr1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019862 677763 SCARNA21 http://www.ncbi.nlm.nih.gov/gene/?term=677763 "ACA68A, SCARNA21 " snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019863 677765 SCARNA18 http://www.ncbi.nlm.nih.gov/gene/?term=677765 "SCARNA18A, U109 " snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019864 677766 SCARNA2 http://www.ncbi.nlm.nih.gov/gene/?term=677766 "HBII-382, mgU2-25/61 " lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019865 677767 SCARNA7 http://www.ncbi.nlm.nih.gov/gene/?term=677767 U90 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019866 677768 SCARNA13 http://www.ncbi.nlm.nih.gov/gene/?term=677768 U93 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019867 677768 SCARNA13 http://www.ncbi.nlm.nih.gov/gene/?term=677768 U93 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019868 67776 Vwa5a http://www.ncbi.nlm.nih.gov/gene/?term=67776 "5830475I06Rik, AW552491, BCSC-1, E130119J22, Loh11cr2a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019869 677771 SCARNA4 http://www.ncbi.nlm.nih.gov/gene/?term=677771 ACA26 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019870 677772 SCARNA6 http://www.ncbi.nlm.nih.gov/gene/?term=677772 U88 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019871 677772 SCARNA6 http://www.ncbi.nlm.nih.gov/gene/?term=677772 U88 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00019872 677772 SCARNA6 http://www.ncbi.nlm.nih.gov/gene/?term=677772 U88 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00019873 677772 SCARNA6 http://www.ncbi.nlm.nih.gov/gene/?term=677772 U88 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "On the other hand, sdRNAs of only three Cajal body snoRNAs (SCARNA6, SCARNA15, SCARNA9L2) were represented in the subcellular libraries. " RLID00019874 677774 SCARNA1 http://www.ncbi.nlm.nih.gov/gene/?term=677774 ACA35 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019875 677775 SCARNA5 http://www.ncbi.nlm.nih.gov/gene/?term=677775 U87 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019876 677776 SCARNA8 http://www.ncbi.nlm.nih.gov/gene/?term=677776 U92 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019877 677778 SCARNA15 http://www.ncbi.nlm.nih.gov/gene/?term=677778 ACA45 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00019878 677778 SCARNA15 http://www.ncbi.nlm.nih.gov/gene/?term=677778 ACA45 snoRNA Homo sapiens 25203660 Cytoplasm HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00019879 677778 SCARNA15 http://www.ncbi.nlm.nih.gov/gene/?term=677778 ACA45 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "On the other hand, sdRNAs of only three Cajal body snoRNAs (SCARNA6, SCARNA15, SCARNA9L2) were represented in the subcellular libraries. " RLID00019880 677778 SCARNA15 http://www.ncbi.nlm.nih.gov/gene/?term=677778 ACA45 snoRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019881 677780 SCARNA11 http://www.ncbi.nlm.nih.gov/gene/?term=677780 ACA57 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019882 677780 SCARNA11 http://www.ncbi.nlm.nih.gov/gene/?term=677780 ACA57 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019883 677781 SCARNA16 http://www.ncbi.nlm.nih.gov/gene/?term=677781 ACA47 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019884 677784 FAM138D http://www.ncbi.nlm.nih.gov/gene/?term=677784 F379 lncRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00019885 67778 Zfp639 http://www.ncbi.nlm.nih.gov/gene/?term=67778 "6230400O18Rik, ANC-2H01, ZASC1, Znf639 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019886 677792 SNORA1 http://www.ncbi.nlm.nih.gov/gene/?term=677792 ACA1 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019887 677793 SNORA2A http://www.ncbi.nlm.nih.gov/gene/?term=677793 ACA2A snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019888 677794 SNORA2B http://www.ncbi.nlm.nih.gov/gene/?term=677794 ACA2b snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019889 677796 SNORA5C http://www.ncbi.nlm.nih.gov/gene/?term=677796 ACA5c snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019890 677797 SNORA7B http://www.ncbi.nlm.nih.gov/gene/?term=677797 ACA7B snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019891 6777 STAT5B http://www.ncbi.nlm.nih.gov/gene/?term=6777 STAT5 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019892 6777 STAT5B http://www.ncbi.nlm.nih.gov/gene/?term=6777 STAT5 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019893 677801 SNORA14A http://www.ncbi.nlm.nih.gov/gene/?term=677801 ACA14a snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019894 677802 SNORA14B http://www.ncbi.nlm.nih.gov/gene/?term=677802 ACA14b snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019895 677803 SNORA15 http://www.ncbi.nlm.nih.gov/gene/?term=677803 "ACA15A, SNORA15 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019896 677804 SNORA17A http://www.ncbi.nlm.nih.gov/gene/?term=677804 "ACA17, SNORA17 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00019897 677805 SNORA18 http://www.ncbi.nlm.nih.gov/gene/?term=677805 ACA18 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019898 677805 SNORA18 http://www.ncbi.nlm.nih.gov/gene/?term=677805 ACA18 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019899 677806 SNORA20 http://www.ncbi.nlm.nih.gov/gene/?term=677806 ACA20 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00019900 677806 SNORA20 http://www.ncbi.nlm.nih.gov/gene/?term=677806 ACA20 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019901 677808 SNORA23 http://www.ncbi.nlm.nih.gov/gene/?term=677808 ACA23 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019902 677809 SNORA24 http://www.ncbi.nlm.nih.gov/gene/?term=677809 "ACA24A, SNORA24 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019903 677809 SNORA24 http://www.ncbi.nlm.nih.gov/gene/?term=677809 "ACA24A, SNORA24 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019904 677810 SNORA26 http://www.ncbi.nlm.nih.gov/gene/?term=677810 HBI-6 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019905 677811 SNORA28 http://www.ncbi.nlm.nih.gov/gene/?term=677811 ACA28 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019906 677812 SNORA29 http://www.ncbi.nlm.nih.gov/gene/?term=677812 ACA29 snoRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00019907 677813 SNORA30 http://www.ncbi.nlm.nih.gov/gene/?term=677813 "ACA30A, SNORA30 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019908 677814 SNORA31 http://www.ncbi.nlm.nih.gov/gene/?term=677814 "ACA31A, SNORA31 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00019909 677814 SNORA31 http://www.ncbi.nlm.nih.gov/gene/?term=677814 "ACA31A, SNORA31 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019910 677815 SNORA2C http://www.ncbi.nlm.nih.gov/gene/?term=677815 "ACA34, MIR1291, SNORA34 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019911 677819 SNORA37 http://www.ncbi.nlm.nih.gov/gene/?term=677819 ACA37 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019912 677820 SNORA38 http://www.ncbi.nlm.nih.gov/gene/?term=677820 ACA38 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019913 677823 SNORA80E http://www.ncbi.nlm.nih.gov/gene/?term=677823 "ACA42, SNORA42 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00019914 677823 SNORA80E http://www.ncbi.nlm.nih.gov/gene/?term=677823 "ACA42, SNORA42 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019915 677824 SNORA17B http://www.ncbi.nlm.nih.gov/gene/?term=677824 "ACA43, SNORA43 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019916 677824 SNORA17B http://www.ncbi.nlm.nih.gov/gene/?term=677824 "ACA43, SNORA43 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019917 677824 SNORA17B http://www.ncbi.nlm.nih.gov/gene/?term=677824 "ACA43, SNORA43 " snoRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019918 677825 SNORA44 http://www.ncbi.nlm.nih.gov/gene/?term=677825 ACA44 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00019919 677826 SNORA3B http://www.ncbi.nlm.nih.gov/gene/?term=677826 "ACA3-2, SNORA45, SNORA45B " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019920 677827 SNORA46 http://www.ncbi.nlm.nih.gov/gene/?term=677827 ACA46 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00019921 677827 SNORA46 http://www.ncbi.nlm.nih.gov/gene/?term=677827 ACA46 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019922 677827 SNORA46 http://www.ncbi.nlm.nih.gov/gene/?term=677827 ACA46 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019923 677828 SNORA47 http://www.ncbi.nlm.nih.gov/gene/?term=677828 HBI-115 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019924 677829 SNORA49 http://www.ncbi.nlm.nih.gov/gene/?term=677829 ACA49 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019925 677830 SNORA50A http://www.ncbi.nlm.nih.gov/gene/?term=677830 "ACA50, SNORA50, SNORA76A " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019926 677832 SNORA53 http://www.ncbi.nlm.nih.gov/gene/?term=677832 ACA53 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019927 677832 SNORA53 http://www.ncbi.nlm.nih.gov/gene/?term=677832 ACA53 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019928 677832 SNORA53 http://www.ncbi.nlm.nih.gov/gene/?term=677832 ACA53 snRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019929 677833 SNORA54 http://www.ncbi.nlm.nih.gov/gene/?term=677833 ACA54 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019930 677834 SNORA55 http://www.ncbi.nlm.nih.gov/gene/?term=677834 ACA55 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019931 677837 SNORA60 http://www.ncbi.nlm.nih.gov/gene/?term=677837 ACA60 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019932 677838 SNORA61 http://www.ncbi.nlm.nih.gov/gene/?term=677838 ACA61 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019933 677838 SNORA61 http://www.ncbi.nlm.nih.gov/gene/?term=677838 ACA61 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019934 677839 SNORA71C http://www.ncbi.nlm.nih.gov/gene/?term=677839 U71c snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019935 677840 SNORA71D http://www.ncbi.nlm.nih.gov/gene/?term=677840 U71d snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019936 677841 SNORA74B http://www.ncbi.nlm.nih.gov/gene/?term=677841 U19-2 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019937 677842 SNORA50C http://www.ncbi.nlm.nih.gov/gene/?term=677842 "ACA62, SNORA76, SNORA76C " snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019938 677844 SNORA78 http://www.ncbi.nlm.nih.gov/gene/?term=677844 ACA64 snoRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00019939 677845 SNORA79 http://www.ncbi.nlm.nih.gov/gene/?term=677845 "ACA65A, SNORA79 " snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019940 677846 SNORA80A http://www.ncbi.nlm.nih.gov/gene/?term=677846 "ACA67, SNORA80 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019941 677848 SNORD1A http://www.ncbi.nlm.nih.gov/gene/?term=677848 "R38A, snR38A " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00019942 677849 SNORD1B http://www.ncbi.nlm.nih.gov/gene/?term=677849 "R38B, snR38B " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019943 677849 SNORD1B http://www.ncbi.nlm.nih.gov/gene/?term=677849 "R38B, snR38B " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00019944 677849 SNORD1B http://www.ncbi.nlm.nih.gov/gene/?term=677849 "R38B, snR38B " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019945 67785 Zmym4 http://www.ncbi.nlm.nih.gov/gene/?term=67785 "6330503C17Rik, AI480785, AW493829, CDIR, D630001M21, MYM, Zfp262, Znf262, mKIAA0425 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019946 677862 gdf1 http://www.ncbi.nlm.nih.gov/gene/?term=677862 "dvr-1, dvr1, gdf-1, vg1 " mRNA Xenopus laevis 8223259 Cytoskeleton Oocyte In situ hybridization "Furthermore, Vg1 and Xcat-2 RNA appear to co-distribute to the cortex, a region particularly concentrated in cytoskeletal elements which include intermediate laments. " RLID00019947 677862 gdf1 http://www.ncbi.nlm.nih.gov/gene/?term=677862 "dvr-1, dvr1, gdf-1, vg1 " mRNA Xenopus laevis 9148809 Cytoplasm Oocyte In situ hybridization "Figure 3 Vg1 mRNA localization involves an interaction with the ER. (A) Vera cross-linking activity cosediments with ER membranes. Cytoplasmic extracts from pooled oocytes (stage IV through VI) were fractionated by sucrose density gradient sedimentation. (D) Endogenous Vg1 mRNA is associated with a subcompartment of the ER during localization. Endogenous Vg1 mRNA is distributed throughout the cytoplasm of early stage II oocytes (Fig. 3D), but at the transition between stages II and III (II/III) of oogenesis, Vg1 mRNA accumulates in a wedge-shaped region between the nucleus and vegetal cortex (Fig.3D) (5). As oogenesis proceeds to stage III, Vg1 mRNA labeling accumulates at the vegetal cortex (Fig. 3D) (5, 12,13). Before localization, Vg1 mRNA and the ER are probably not associated, because in stage II oocytes the Vg1 mRNA distribution is punctate and the ER is reticular (Fig. 3D). " RLID00019948 677862 gdf1 http://www.ncbi.nlm.nih.gov/gene/?term=677862 "dvr-1, dvr1, gdf-1, vg1 " mRNA Xenopus laevis 9148809 Vegetal Oocyte In situ hybridization "Figure 3 Vg1 mRNA localization involves an interaction with the ER. (A) Vera cross-linking activity cosediments with ER membranes. Cytoplasmic extracts from pooled oocytes (stage IV through VI) were fractionated by sucrose density gradient sedimentation. (D) Endogenous Vg1 mRNA is associated with a subcompartment of the ER during localization. Endogenous Vg1 mRNA is distributed throughout the cytoplasm of early stage II oocytes (Fig. 3D), but at the transition between stages II and III (II/III) of oogenesis, Vg1 mRNA accumulates in a wedge-shaped region between the nucleus and vegetal cortex (Fig.3D) (5). As oogenesis proceeds to stage III, Vg1 mRNA labeling accumulates at the vegetal cortex (Fig. 3D) (5, 12,13). Before localization, Vg1 mRNA and the ER are probably not associated, because in stage II oocytes the Vg1 mRNA distribution is punctate and the ER is reticular (Fig. 3D). " RLID00019949 677862 gdf1 http://www.ncbi.nlm.nih.gov/gene/?term=677862 "dvr-1, dvr1, gdf-1, vg1 " mRNA Xenopus laevis 9545550 Mitochondrion Oocyte In situ hybridization Whole-mount in situ hybridization with Xlsirt RNA probe in late stage 1 oocytes. The arrow points to the endogenous Xlsirt RNA localized in the METRO region of the mitochondrial cloud. RLID00019950 677862 gdf1 http://www.ncbi.nlm.nih.gov/gene/?term=677862 "dvr-1, dvr1, gdf-1, vg1 " mRNA Xenopus laevis 9545550 Cytoplasm Oocyte In situ hybridization "To help distinguish between these alternatives, we made several constructs in which we linked the Xlsirts localization signals to various regions of the full-length Vg1 mRNA (Fig. 1) and tested the ability of the chimeric RNAs to move to the mitochondrial cloud in stage 1 oocytes. Fig. 2. Localization of endogenous and exogenous Xlsirts and Vg1 RNAs in oocytes. (A) Whole-mount in situ hybridization with Xlsirt RNA probe in late stage 1 oocytes. The arrow points to the endogenous Xlsirt RNA localized in the METRO region of the mitochondrial cloud. (C) Whole mount in situ hybridization with Vg1 RNA probe in late stage 1 oocytes, Vg1 RNA is dispersed in the oocyte cytoplasm and is excluded from the mitochondrial cloud (arrow). (D) Injected Vg1 RNA spreads throughout the cytoplasm and is excluded from the mitochondrial cloud in late stage 1 oocytes (arrow). " RLID00019951 677862 gdf1 http://www.ncbi.nlm.nih.gov/gene/?term=677862 "dvr-1, dvr1, gdf-1, vg1 " mRNA Xenopus laevis 15496522 Vegetal Oocyte Immunofluorescence "We further showed that XStau proteins are transiently phosphorylated by the MAPK pathway during meiotic maturation, a period during which RNAs such as Vg1 RNA are released from their tight localization at the vegetal cortex. " RLID00019952 677862 gdf1 http://www.ncbi.nlm.nih.gov/gene/?term=677862 "dvr-1, dvr1, gdf-1, vg1 " mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00019953 677862 gdf1 http://www.ncbi.nlm.nih.gov/gene/?term=677862 "dvr-1, dvr1, gdf-1, vg1 " mRNA Xenopus laevis 11309203 Vegetal Oocyte In situ hybridization "The IVC retained mRNAs with a granular texture, and their distribution patterns resembled those of the whole oocyte. Vg1 was distributed in the entire cortex, whereas Xwnt-11 and Xcat-2 were both concentrated as a disc at the vegetal pole. " RLID00019954 677862 gdf1 http://www.ncbi.nlm.nih.gov/gene/?term=677862 "dvr-1, dvr1, gdf-1, vg1 " mRNA Xenopus laevis 9545550 Endoplasmic reticulum Oocyte In situ hybridization Fig. 4. Co-localization of ER and localized RNAs. (A) Stage 1 oocyte showing endogenous Vg1 RNA distributed throughout the cytoplasm (blue color) by in situ hybridization and the ER on the periphery of the mitochondrial cloud (red) by immunostaining with the GRP78 antibody (the arrow is pointing to the ER surrounding the cloud). RLID00019955 677862 gdf1 http://www.ncbi.nlm.nih.gov/gene/?term=677862 "dvr-1, dvr1, gdf-1, vg1 " mRNA Xenopus laevis 11784070 Vegetal Oocyte In situ hybridization|RT-PCR "While punctate staining for Vg1 mRNA was present at the vegetal cortex of uninjected oocytes, no localized Vg1 mRNA, either cortical or subcortical, was observed in the VegT-depleted oocytes (Figs. 3D and 3F). " RLID00019956 677862 gdf1 http://www.ncbi.nlm.nih.gov/gene/?term=677862 "dvr-1, dvr1, gdf-1, vg1 " mRNA Xenopus laevis 23626739 Germ plasm Oocyte Microscopy "We find that in mid oogenesis nanos1 RNA also localises to germ plasm but also by the late pathway. Late pathway RNAs,Vg1 and VegT, also may localise into germ plasm. " RLID00019957 67789 Dalrd3 http://www.ncbi.nlm.nih.gov/gene/?term=67789 "6330580J24Rik, C77829, mir-425 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019958 6778 STAT6 http://www.ncbi.nlm.nih.gov/gene/?term=6778 "D12S1644, IL-4-STAT, STAT6B, STAT6C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019959 67791 6530411M01Rik http://www.ncbi.nlm.nih.gov/gene/?term=67791 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019960 67797 Snrnp48 http://www.ncbi.nlm.nih.gov/gene/?term=67797 "1110050F08Rik, 6530403A03Rik, C6orf151 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019961 67797 Snrnp48 http://www.ncbi.nlm.nih.gov/gene/?term=67797 "1110050F08Rik, 6530403A03Rik, C6orf151 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019962 677 ZFP36L1 http://www.ncbi.nlm.nih.gov/gene/?term=677 "BRF1, Berg36, ERF-1, ERF1, RNF162B, TIS11B, cMG1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019963 67803 Limd2 http://www.ncbi.nlm.nih.gov/gene/?term=67803 "0610025L06Rik, AI413966 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019964 67804 Snx2 http://www.ncbi.nlm.nih.gov/gene/?term=67804 0610030A03Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019965 6780 STAU1 http://www.ncbi.nlm.nih.gov/gene/?term=6780 "PPP1R150, STAU " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019966 6780 STAU1 http://www.ncbi.nlm.nih.gov/gene/?term=6780 "PPP1R150, STAU " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019967 6780 STAU1 http://www.ncbi.nlm.nih.gov/gene/?term=6780 "PPP1R150, STAU " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00019968 67821 Atp1b4 http://www.ncbi.nlm.nih.gov/gene/?term=67821 1110020B02Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019969 67824 Nmral1 http://www.ncbi.nlm.nih.gov/gene/?term=67824 "1110025F24Rik, AI256624 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019970 67826 Snap47 http://www.ncbi.nlm.nih.gov/gene/?term=67826 "1110031B06Rik, SNAP-47 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019971 6782 HSPA13 http://www.ncbi.nlm.nih.gov/gene/?term=6782 STCH mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00019972 6782 HSPA13 http://www.ncbi.nlm.nih.gov/gene/?term=6782 STCH mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019973 67830 Rer1 http://www.ncbi.nlm.nih.gov/gene/?term=67830 "1110060F11Rik, 5830454N22Rik, AU043380 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019974 67832 Brix1 http://www.ncbi.nlm.nih.gov/gene/?term=67832 "1110064N10Rik, Bxdc2, C76935 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019975 67838 Dnajb11 http://www.ncbi.nlm.nih.gov/gene/?term=67838 "1810031F23Rik, ABBP-2, AL024055, Dj9, ERdj3, ERj3p " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019976 6783 SULT1E1 http://www.ncbi.nlm.nih.gov/gene/?term=6783 "EST, EST-1, ST1E1, STE " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019977 67841 Atg3 http://www.ncbi.nlm.nih.gov/gene/?term=67841 "2610016C12Rik, APG3, Apg3ll, PC3-96, Atg3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019978 67842 Nop9 http://www.ncbi.nlm.nih.gov/gene/?term=67842 2610027L16Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019979 67845 Rnf115 http://www.ncbi.nlm.nih.gov/gene/?term=67845 "2610028E05Rik, AU042696, Zfp364 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019980 67848 Ddx55 http://www.ncbi.nlm.nih.gov/gene/?term=67848 "2810021H22Rik, mKIAA1595 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019981 6785 ELOVL4 http://www.ncbi.nlm.nih.gov/gene/?term=6785 "ADMD, CT118, ISQMR, SCA34, STGD2, STGD3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019982 67860 S100a16 http://www.ncbi.nlm.nih.gov/gene/?term=67860 "2300002L21Rik, AI325039, AI663996, DT1P1A7, S100F " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019983 67864 Yipf4 http://www.ncbi.nlm.nih.gov/gene/?term=67864 2310034L04Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019984 67868 Cela3b http://www.ncbi.nlm.nih.gov/gene/?term=67868 "0910001F22Rik, 2310074F01Rik, AI504000, Ela3, Ela3b " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00019985 6786 STIM1 http://www.ncbi.nlm.nih.gov/gene/?term=6786 "D11S4896E, GOK, IMD10, STRMK, TAM, TAM1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019986 67873 Mri1 http://www.ncbi.nlm.nih.gov/gene/?term=67873 2410018C20Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019987 67878 Tmem33 http://www.ncbi.nlm.nih.gov/gene/?term=67878 "1110006G02Rik, 1600019D15Rik, 2410089A21Rik, 2700052H22Rik, 5430406L04Rik, AA388285, AI314185, AI426615, db83 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019988 6787 NEK4 http://www.ncbi.nlm.nih.gov/gene/?term=6787 "NRK2, STK2, pp12301 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019989 67880 Dcxr http://www.ncbi.nlm.nih.gov/gene/?term=67880 "0610038K04Rik, 1810027P18Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019990 67881 Mdp1 http://www.ncbi.nlm.nih.gov/gene/?term=67881 "1810034K20Rik, AI035604 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019991 67883 Uxs1 http://www.ncbi.nlm.nih.gov/gene/?term=67883 "1600025I13Rik, AI451869, AI649125, AW550562 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019992 67884 1810043G02Rik http://www.ncbi.nlm.nih.gov/gene/?term=67884 "AV026620, D10Jhu13e " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019993 67886 Camsap2 http://www.ncbi.nlm.nih.gov/gene/?term=67886 "1600013L13Rik, 4930541M15Rik, Camsap1l1, mKIAA1078 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019994 67886 Camsap2 http://www.ncbi.nlm.nih.gov/gene/?term=67886 "1600013L13Rik, 4930541M15Rik, Camsap1l1, mKIAA1078 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019995 67887 Saraf http://www.ncbi.nlm.nih.gov/gene/?term=67887 "1810045K07Rik, Tmem66 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019996 6788 STK3 http://www.ncbi.nlm.nih.gov/gene/?term=6788 "KRS1, MST2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00019997 6788 STK3 http://www.ncbi.nlm.nih.gov/gene/?term=6788 "KRS1, MST2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00019998 67897 Rnmt http://www.ncbi.nlm.nih.gov/gene/?term=67897 "2610002P10Rik, AI848273, Rg7mt1, mKIAA0398 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00019999 67898 Pef1 http://www.ncbi.nlm.nih.gov/gene/?term=67898 "2600002E23Rik, Peflin " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020000 6789 STK4 http://www.ncbi.nlm.nih.gov/gene/?term=6789 "KRS2, MST1, TIIAC, YSK3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020001 6789 STK4 http://www.ncbi.nlm.nih.gov/gene/?term=6789 "KRS2, MST1, TIIAC, YSK3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020002 6789 STK4 http://www.ncbi.nlm.nih.gov/gene/?term=6789 "KRS2, MST1, TIIAC, YSK3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020003 6789 STK4 http://www.ncbi.nlm.nih.gov/gene/?term=6789 "KRS2, MST1, TIIAC, YSK3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020004 6789 STK4 http://www.ncbi.nlm.nih.gov/gene/?term=6789 "KRS2, MST1, TIIAC, YSK3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020005 678 ZFP36L2 http://www.ncbi.nlm.nih.gov/gene/?term=678 "BRF2, ERF-2, ERF2, RNF162C, TIS11D " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020006 678 ZFP36L2 http://www.ncbi.nlm.nih.gov/gene/?term=678 "BRF2, ERF-2, ERF2, RNF162C, TIS11D " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020007 67903 Gipc1 http://www.ncbi.nlm.nih.gov/gene/?term=67903 "GIPC, Glut1CIP, Rgs19ip1, Semcap1, TIP-2, TaxIP2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020008 6790 AURKA http://www.ncbi.nlm.nih.gov/gene/?term=6790 "AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020009 6790 AURKA http://www.ncbi.nlm.nih.gov/gene/?term=6790 "AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020010 67920 Mak16 http://www.ncbi.nlm.nih.gov/gene/?term=67920 "2600016B03Rik, AI314911, Rbm13 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020011 67923 Tceb1 http://www.ncbi.nlm.nih.gov/gene/?term=67923 "2610043E24Rik, 2610301I15Rik, AA407206, AI987979, AW049146 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020012 6792 CDKL5 http://www.ncbi.nlm.nih.gov/gene/?term=6792 "CFAP247, EIEE2, ISSX, STK9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020013 67933 Hcfc2 http://www.ncbi.nlm.nih.gov/gene/?term=67933 "1700129L13Rik, AU019838 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020014 67939 Prorsd1 http://www.ncbi.nlm.nih.gov/gene/?term=67939 "2010316F05Rik, Ncrna00117, Prdxdd1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020015 67943 Mesdc2 http://www.ncbi.nlm.nih.gov/gene/?term=67943 "2210015O11Rik, AW537813, mKIAA0081, mesd, msd " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020016 67944 Tex13a http://www.ncbi.nlm.nih.gov/gene/?term=67944 1700025D03Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020017 67945 Rpl41 http://www.ncbi.nlm.nih.gov/gene/?term=67945 "1810055P16Rik, 2210411K19Rik " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020018 67945 Rpl41 http://www.ncbi.nlm.nih.gov/gene/?term=67945 "1810055P16Rik, 2210411K19Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020019 6794 STK11 http://www.ncbi.nlm.nih.gov/gene/?term=6794 "LKB1, PJS, hLKB1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020020 67952 Tomm20 http://www.ncbi.nlm.nih.gov/gene/?term=67952 "1810060K07Rik, BB284719, Gm19268, MAS20, MOM19, TOM20, mKIAA0016 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020021 67955 Sugt1 http://www.ncbi.nlm.nih.gov/gene/?term=67955 "2410174K12Rik, SGT1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020022 67956 Setd8 http://www.ncbi.nlm.nih.gov/gene/?term=67956 "2410195B05Rik, AA617402, AW536475, PR-SET7, PR/SET07 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020023 67958 U2surp http://www.ncbi.nlm.nih.gov/gene/?term=67958 "2610101N10Rik, AU023006, Sr140 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020024 6795 AURKC http://www.ncbi.nlm.nih.gov/gene/?term=6795 "AIE2, AIK3, ARK3, AurC, HEL-S-90, SPGF5, STK13, aurora-C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020025 67967 Pold3 http://www.ncbi.nlm.nih.gov/gene/?term=67967 "2410142G14Rik, C85233, P66, P68 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020026 67968 Ooep http://www.ncbi.nlm.nih.gov/gene/?term=67968 "2410146L05Rik, Floped, Moep19, Sddr " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020027 67972 Atp2b1 http://www.ncbi.nlm.nih.gov/gene/?term=67972 "2810442I22Rik, E130111D10Rik, Pmca1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020028 67974 Ccny http://www.ncbi.nlm.nih.gov/gene/?term=67974 "1700025H17Rik, 3110050L10Rik, 4631402G10Rik, 5730405I09Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020029 67976 Trabd http://www.ncbi.nlm.nih.gov/gene/?term=67976 "5730502D15Rik, AL023039 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020030 67980 Gnpda2 http://www.ncbi.nlm.nih.gov/gene/?term=67980 "4921523I18Rik, 4933412A11Rik, BB189630, GNPDA, Gnp2, Sb52, mKIAA4008 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020031 67981 Hormad1 http://www.ncbi.nlm.nih.gov/gene/?term=67981 "4921522K05Rik, Nohma " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020032 67988 Tmx3 http://www.ncbi.nlm.nih.gov/gene/?term=67988 "6430411B10Rik, A730024F05Rik, AV259382, Txndc10, mKIAA1830 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020033 67994 Mrps11 http://www.ncbi.nlm.nih.gov/gene/?term=67994 "0710005I03Rik, C79873 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020034 67996 Srsf6 http://www.ncbi.nlm.nih.gov/gene/?term=67996 "1210001E11Rik, AI314910, AW146126, Sfrs6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020035 68001 1110004E09Rik http://www.ncbi.nlm.nih.gov/gene/?term=68001 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020036 68011 Snrpg http://www.ncbi.nlm.nih.gov/gene/?term=68011 "2810024K17Rik, AL022803, SMG, sm-G, snRNP-G " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020037 68018 Col4a3bp http://www.ncbi.nlm.nih.gov/gene/?term=68018 "2810404O15Rik, 9230101K08Rik, AU016711, CERT, GPBP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020038 68026 2810417H13Rik http://www.ncbi.nlm.nih.gov/gene/?term=68026 "AA409629, Ns5apt9, Ns5atp9, PAF15, Paf, mKIAA0101, p15(PAF) " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020039 68031 Rnf146 http://www.ncbi.nlm.nih.gov/gene/?term=68031 "2610509H23Rik, Iduna " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020040 68033 Cox19 http://www.ncbi.nlm.nih.gov/gene/?term=68033 "1810074D02Rik, 2810437L13Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020041 68035 Rbm42 http://www.ncbi.nlm.nih.gov/gene/?term=68035 "1700003D06Rik, 3100004P22Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020042 68037 2900093K20Rik http://www.ncbi.nlm.nih.gov/gene/?term=68037 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020043 68040 Zfp593 http://www.ncbi.nlm.nih.gov/gene/?term=68040 "3110024A21Rik, AV062409, E130106C14Rik, ZNF593 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020044 68045 2700060E02Rik http://www.ncbi.nlm.nih.gov/gene/?term=68045 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020045 6804 STX1A http://www.ncbi.nlm.nih.gov/gene/?term=6804 "HPC-1, P35-1, STX1, SYN1A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020046 68050 Akirin1 http://www.ncbi.nlm.nih.gov/gene/?term=68050 6330407G11Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020047 68051 Nutf2 http://www.ncbi.nlm.nih.gov/gene/?term=68051 "2700067I02Rik, AI115459, AI413596, AW546000, Ntf2, Ntf3, PP15 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020048 68052 Rps13 http://www.ncbi.nlm.nih.gov/gene/?term=68052 2700063M04Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020049 68053 Ubxn2b http://www.ncbi.nlm.nih.gov/gene/?term=68053 "3110003A22Rik, 6430407D20Rik, AI451665, p37 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020050 68058 Chd1l http://www.ncbi.nlm.nih.gov/gene/?term=68058 "4432404A22Rik, Alc1, Snf2p " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020051 68059 Tm9sf2 http://www.ncbi.nlm.nih.gov/gene/?term=68059 "1500001N15Rik, AA536814, D14Ertd64e, P76 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020052 68066 Slc25a39 http://www.ncbi.nlm.nih.gov/gene/?term=68066 "3010027G13Rik, D11Ertd333e " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020053 68067 3010026O09Rik http://www.ncbi.nlm.nih.gov/gene/?term=68067 "2900016G09Rik, AI851514, AW475975 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020054 68074 A930013F10Rik http://www.ncbi.nlm.nih.gov/gene/?term=68074 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020055 68079 Pdcd2l http://www.ncbi.nlm.nih.gov/gene/?term=68079 6030457N17Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020056 68087 Dcakd http://www.ncbi.nlm.nih.gov/gene/?term=68087 "3010024O21Rik, 6720485C15Rik, AI849483 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020057 68089 Arpc4 http://www.ncbi.nlm.nih.gov/gene/?term=68089 "20kDa, 5330419I20Rik, AI327076, p20-Arc " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020058 68094 Smarcc2 http://www.ncbi.nlm.nih.gov/gene/?term=68094 5930405J04Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020059 68095 Ociad1 http://www.ncbi.nlm.nih.gov/gene/?term=68095 "6030432N09Rik, AI481327, AW557942, Asrij, B230209J16Rik, BB021357, Emi2, Imi2, OCIA, TPA018 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020060 68099 Fam92a http://www.ncbi.nlm.nih.gov/gene/?term=68099 "6720467C03Rik1, Fam92a " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020061 6809 STX3 http://www.ncbi.nlm.nih.gov/gene/?term=6809 STX3A mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020062 68107 Cntd1 http://www.ncbi.nlm.nih.gov/gene/?term=68107 "1700051C09Rik, 4921513J16Rik, 5430417M23Rik, Cntd " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020063 68108 Snhg17 http://www.ncbi.nlm.nih.gov/gene/?term=68108 9430008C03Rik lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020064 6810 STX4 http://www.ncbi.nlm.nih.gov/gene/?term=6810 "STX4A, p35-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020065 6810 STX4 http://www.ncbi.nlm.nih.gov/gene/?term=6810 "STX4A, p35-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020066 6811 STX5 http://www.ncbi.nlm.nih.gov/gene/?term=6811 "SED5A, STX5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020067 6811 STX5 http://www.ncbi.nlm.nih.gov/gene/?term=6811 "SED5, STX5A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020068 68127 B230217C12Rik http://www.ncbi.nlm.nih.gov/gene/?term=68127 AI840637 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020069 6812 STXBP1 http://www.ncbi.nlm.nih.gov/gene/?term=6812 "MUNC18-1, NSEC1, P67, RBSEC1, UNC18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020070 68133 Gcsh http://www.ncbi.nlm.nih.gov/gene/?term=68133 "1100001L02Rik, 5730591C18Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020071 68134 Upf3b http://www.ncbi.nlm.nih.gov/gene/?term=68134 "5730594O13Rik, AI317193, AW541158, RENT3B, UPF3X " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020072 68135 Eif3h http://www.ncbi.nlm.nih.gov/gene/?term=68135 "1110008A16Rik, 40kD, 9430017H16Rik, EIF3-P40, EIF3-gamma, Eif3s3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020073 68140 Tigd2 http://www.ncbi.nlm.nih.gov/gene/?term=68140 3632410O17Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020074 68142 Ino80 http://www.ncbi.nlm.nih.gov/gene/?term=68142 "2310079N15Rik, 4632409L19Rik, Inoc1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020075 68142 Ino80 http://www.ncbi.nlm.nih.gov/gene/?term=68142 "2310079N15Rik, 4632409L19Rik, Inoc1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020076 68145 Etaa1 http://www.ncbi.nlm.nih.gov/gene/?term=68145 "5730466H23Rik, AA672646 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020077 6814 STXBP3 http://www.ncbi.nlm.nih.gov/gene/?term=6814 "MUNC18-3, MUNC18C, PSP, UNC-18C " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020078 6814 STXBP3 http://www.ncbi.nlm.nih.gov/gene/?term=6814 "MUNC18-3, MUNC18C, PSP, UNC-18C " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020079 6814 STXBP3 http://www.ncbi.nlm.nih.gov/gene/?term=6814 "MUNC18-3, MUNC18C, PSP, UNC-18C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020080 68153 Gtf2e2 http://www.ncbi.nlm.nih.gov/gene/?term=68153 "34kDa, AI462509, C330006J08Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020081 68157 6720475J19Rik http://www.ncbi.nlm.nih.gov/gene/?term=68157 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020082 6815 STYX http://www.ncbi.nlm.nih.gov/gene/?term=6815 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020083 6815 STYX http://www.ncbi.nlm.nih.gov/gene/?term=6815 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020084 6815 STYX http://www.ncbi.nlm.nih.gov/gene/?term=6815 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020085 68161 A930005H10Rik http://www.ncbi.nlm.nih.gov/gene/?term=68161 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020086 68162 A930003A15Rik http://www.ncbi.nlm.nih.gov/gene/?term=68162 AI853191 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020087 68166 Spire1 http://www.ncbi.nlm.nih.gov/gene/?term=68166 "6030430B19Rik, AI415299, AU022898, AW550622, Spir-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020088 68168 A930009E08Rik http://www.ncbi.nlm.nih.gov/gene/?term=68168 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020089 68174 4930534H18Rik http://www.ncbi.nlm.nih.gov/gene/?term=68174 AV040741 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020090 68180 Hyi http://www.ncbi.nlm.nih.gov/gene/?term=68180 "2700033B16Rik, 6430559E15Rik, HT036 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020091 68185 Coa4 http://www.ncbi.nlm.nih.gov/gene/?term=68185 "5330414O08Rik, AI115477, AW047259, Chchd8, E2ig2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020092 68187 Fam135a http://www.ncbi.nlm.nih.gov/gene/?term=68187 "4921533L14Rik, AI256732, AI835491 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020093 68188 Sympk http://www.ncbi.nlm.nih.gov/gene/?term=68188 "1500016F02Rik, 4632415H16Rik, AA125406, AI449890, SPK, SYM " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020094 68189 5330431K02Rik http://www.ncbi.nlm.nih.gov/gene/?term=68189 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020095 68193 Rpl24 http://www.ncbi.nlm.nih.gov/gene/?term=68193 "0610008L05Rik, Bst " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020096 68193 Rpl24 http://www.ncbi.nlm.nih.gov/gene/?term=68193 "0610008L05Rik, Bst " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00020097 68194 Ndufb4 http://www.ncbi.nlm.nih.gov/gene/?term=68194 "0610006N12Rik, 1300010H20Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020098 68194 Ndufb4 http://www.ncbi.nlm.nih.gov/gene/?term=68194 "0610006N12Rik, 1300010H20Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020099 68201 Ccdc34 http://www.ncbi.nlm.nih.gov/gene/?term=68201 "2810027O19Rik, 4930522P10Rik, AI596202 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020100 68205 Urm1 http://www.ncbi.nlm.nih.gov/gene/?term=68205 2900073H19Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020101 68205 Urm1 http://www.ncbi.nlm.nih.gov/gene/?term=68205 2900073H19Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020102 68209 Rnaseh2c http://www.ncbi.nlm.nih.gov/gene/?term=68209 "1500026D16Rik, AYP1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020103 68219 Nudt21 http://www.ncbi.nlm.nih.gov/gene/?term=68219 "25kDa, 3110048P04Rik, 5730530J16Rik, AU014860, AW549947, Cpsf5 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020104 6821 SUOX http://www.ncbi.nlm.nih.gov/gene/?term=6821 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020105 68239 Krt42 http://www.ncbi.nlm.nih.gov/gene/?term=68239 "2410039E07Rik, K17n, Ka22, ecat6 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020106 68241 Fam195a http://www.ncbi.nlm.nih.gov/gene/?term=68241 9530058B02Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020107 68246 1700112J05Rik http://www.ncbi.nlm.nih.gov/gene/?term=68246 1700110A09Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020108 68250 Fam96a http://www.ncbi.nlm.nih.gov/gene/?term=68250 5730536A07Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020109 68259 Ift80 http://www.ncbi.nlm.nih.gov/gene/?term=68259 "4921524P20Rik, Wdr56, mKIAA1374 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020110 68272 Rbm28 http://www.ncbi.nlm.nih.gov/gene/?term=68272 "2810480G15Rik, AI503051 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020111 68274 Toporsl http://www.ncbi.nlm.nih.gov/gene/?term=68274 4930547C10Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020112 6827 SUPT4H1 http://www.ncbi.nlm.nih.gov/gene/?term=6827 "SPT4, SPT4H, SUPT4H, Supt4a " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020113 68281 4930430F08Rik http://www.ncbi.nlm.nih.gov/gene/?term=68281 "4930571E09Rik, A730088G13Rik, AW551239, C430008C19Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020114 68292 Stt3b http://www.ncbi.nlm.nih.gov/gene/?term=68292 "1300006C19Rik, Simp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020115 68295 Aar2 http://www.ncbi.nlm.nih.gov/gene/?term=68295 0610011L14Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020116 6829 SUPT5H http://www.ncbi.nlm.nih.gov/gene/?term=6829 "SPT5, SPT5H, Tat-CT1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020117 6829 SUPT5H http://www.ncbi.nlm.nih.gov/gene/?term=6829 "SPT5, SPT5H, Tat-CT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020118 682 BSG http://www.ncbi.nlm.nih.gov/gene/?term=682 "5F7, CD147, EMMPRIN, OK, TCSF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020119 682 BSG http://www.ncbi.nlm.nih.gov/gene/?term=682 "5F7, CD147, EMMPRIN, OK, TCSF " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020120 682 BSG http://www.ncbi.nlm.nih.gov/gene/?term=682 "5F7, CD147, EMMPRIN, M6, OK, TCSF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020121 68308 4933406F09Rik http://www.ncbi.nlm.nih.gov/gene/?term=68308 "1700007H14Rik, 4930429F21Rik, 4930570O04Rik, Gm3768 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020122 6830 SUPT6H http://www.ncbi.nlm.nih.gov/gene/?term=6830 "SPT6, SPT6H, emb-5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020123 68312 Gstm7 http://www.ncbi.nlm.nih.gov/gene/?term=68312 "0610005A07Rik, AI894236, Cd203c " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020124 68323 Nudt22 http://www.ncbi.nlm.nih.gov/gene/?term=68323 "0610006K04Rik, AI851793, AW545547 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020125 68328 Rab13 http://www.ncbi.nlm.nih.gov/gene/?term=68328 "0610007N03Rik, B230212B15Rik " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00020126 6832 SUPV3L1 http://www.ncbi.nlm.nih.gov/gene/?term=6832 SUV3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020127 6833 ABCC8 http://www.ncbi.nlm.nih.gov/gene/?term=6833 "ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, SUR1delta2, TNDM2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020128 68347 0610011F06Rik http://www.ncbi.nlm.nih.gov/gene/?term=68347 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020129 6834 SURF1 http://www.ncbi.nlm.nih.gov/gene/?term=6834 CMT4K mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020130 6834 SURF1 http://www.ncbi.nlm.nih.gov/gene/?term=6834 CMT4K mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020131 68350 Mul1 http://www.ncbi.nlm.nih.gov/gene/?term=68350 "0610009K11Rik, AV000801, Gide " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020132 68355 2010204K13Rik http://www.ncbi.nlm.nih.gov/gene/?term=68355 "0610010M13Rik, Cip7 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020133 6835 SURF2 http://www.ncbi.nlm.nih.gov/gene/?term=6835 SURF-2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020134 6835 SURF2 http://www.ncbi.nlm.nih.gov/gene/?term=6835 SURF-2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020135 68366 Tmem129 http://www.ncbi.nlm.nih.gov/gene/?term=68366 "0610039G24Rik, 2410015J15Rik, AA409575 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020136 6836 SURF4 http://www.ncbi.nlm.nih.gov/gene/?term=6836 ERV29 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020137 6836 SURF4 http://www.ncbi.nlm.nih.gov/gene/?term=6836 ERV29 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020138 68371 Pbld1 http://www.ncbi.nlm.nih.gov/gene/?term=68371 "0610038K03Rik, Mawbp, Pbld " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020139 68375 Ndufa8 http://www.ncbi.nlm.nih.gov/gene/?term=68375 "0610033L03Rik, AW261656 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020140 6837 MED22 http://www.ncbi.nlm.nih.gov/gene/?term=6837 "MED24, SURF5, surf-5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020141 6838 SURF6 http://www.ncbi.nlm.nih.gov/gene/?term=6838 RRP14 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020142 6839 SUV39H1 http://www.ncbi.nlm.nih.gov/gene/?term=6839 "H3-K9-HMTase 1, KMT1A, MG44, SUV39H " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020143 6839 SUV39H1 http://www.ncbi.nlm.nih.gov/gene/?term=6839 "H3-K9-HMTase 1, KMT1A, MG44, SUV39H " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020144 68404 Nrn1 http://www.ncbi.nlm.nih.gov/gene/?term=68404 "0710008J23Rik, Cpg15, Nrn " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020145 68404 Nrn1 http://www.ncbi.nlm.nih.gov/gene/?term=68404 "0710008J23Rik, Cpg15, Nrn " mRNA Mus musculus 26512708 Axon ForeBrain Immunoprecipitation|RIP-Chip "HuD has also been implicated in axonal localization of other neuronal mRNAs including Tau, Neuritin/CPG15, Kv.1.1 and CaMKIIα mRNAs " RLID00020146 68421 Lmbrd1 http://www.ncbi.nlm.nih.gov/gene/?term=68421 "0910001K20Rik, AV347960 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020147 68431 Fbxl15 http://www.ncbi.nlm.nih.gov/gene/?term=68431 "0710008C12Rik, Fbxo37 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020148 68436 Rpl34 http://www.ncbi.nlm.nih.gov/gene/?term=68436 1100001I22Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020149 68441 Rraga http://www.ncbi.nlm.nih.gov/gene/?term=68441 "1300010C19Rik, AI255374, FIP-1, RAGA " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020150 68449 Tbc1d10b http://www.ncbi.nlm.nih.gov/gene/?term=68449 "1110003P22Rik, C87963 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020151 6844 VAMP2 http://www.ncbi.nlm.nih.gov/gene/?term=6844 "SYB2, VAMP-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020152 6844 VAMP2 http://www.ncbi.nlm.nih.gov/gene/?term=6844 "SYB2, VAMP-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020153 6845 VAMP7 http://www.ncbi.nlm.nih.gov/gene/?term=6845 "SYBL1, TI-VAMP, TIVAMP, VAMP-7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020154 6845 VAMP7 http://www.ncbi.nlm.nih.gov/gene/?term=6845 "SYBL1, TI-VAMP, TIVAMP, VAMP-7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020155 68463 Mrpl14 http://www.ncbi.nlm.nih.gov/gene/?term=68463 "1110006I11Rik, AI846816, MRP-L32, Rpml32 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020156 68480 Card19 http://www.ncbi.nlm.nih.gov/gene/?term=68480 "1110007C09Rik, AI851695, Bincard " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020157 68481 Mpzl1 http://www.ncbi.nlm.nih.gov/gene/?term=68481 "1110007A10Rik, PZR " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020158 68497 Arel1 http://www.ncbi.nlm.nih.gov/gene/?term=68497 "1110018G07Rik, AI649076, AW610792, Kiaa0317, mKIAA0317 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020159 684 BST2 http://www.ncbi.nlm.nih.gov/gene/?term=684 "CD317, TETHERIN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020160 684 BST2 http://www.ncbi.nlm.nih.gov/gene/?term=684 "CD317, TETHERIN " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020161 68501 Nsmce2 http://www.ncbi.nlm.nih.gov/gene/?term=68501 "1110014D18Rik, AI661537 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020162 68505 Vps51 http://www.ncbi.nlm.nih.gov/gene/?term=68505 "1110014N23Rik, 3110057M17Rik, AI837850, Ffr " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020163 6850 SYK http://www.ncbi.nlm.nih.gov/gene/?term=6850 p72-Syk mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020164 68519 Eml1 http://www.ncbi.nlm.nih.gov/gene/?term=68519 "1110008N23Rik, A930030P13Rik, AA171013, AI847476, AI853955, ELP79, EMAP, EMAPL, heco " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020165 68520 Zfyve21 http://www.ncbi.nlm.nih.gov/gene/?term=68520 "1110013H04Rik, AW558780, C85416 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020166 68526 Gpr155 http://www.ncbi.nlm.nih.gov/gene/?term=68526 "1110017O10Rik, DEPDC3, F730029F15Rik, PGR22 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020167 68549 Sgol2a http://www.ncbi.nlm.nih.gov/gene/?term=68549 "1110007N04Rik, 4932411A20Rik, 5730576N04Rik, AU018846, AV008062, D1Ertd8e, Sgol2, Tripin " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020168 6854 SYN2 http://www.ncbi.nlm.nih.gov/gene/?term=6854 SYNII mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020169 68558 Ankra2 http://www.ncbi.nlm.nih.gov/gene/?term=68558 "1110004M18Rik, Ankra " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020170 68564 Nufip2 http://www.ncbi.nlm.nih.gov/gene/?term=68564 "1110001M19Rik, 9530056D24Rik, AI256692, AI461731, PIG1, mKIAA1321 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020171 6856 SYPL1 http://www.ncbi.nlm.nih.gov/gene/?term=6856 "H-SP1, SYPL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020172 6856 SYPL1 http://www.ncbi.nlm.nih.gov/gene/?term=6856 "H-SP1, SYPL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020173 6856 SYPL1 http://www.ncbi.nlm.nih.gov/gene/?term=6856 "H-SP1, SYPL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020174 68572 Ict1 http://www.ncbi.nlm.nih.gov/gene/?term=68572 "1110001A02Rik, 1110002E03Rik, MRP-L58 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020175 68576 Lamtor5 http://www.ncbi.nlm.nih.gov/gene/?term=68576 "1110003H18Rik, Hbxip, XIP " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020176 6857 SYT1 http://www.ncbi.nlm.nih.gov/gene/?term=6857 "P65, SVP65, SYT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020177 68585 Rtn4 http://www.ncbi.nlm.nih.gov/gene/?term=68585 "1110020G17Rik, AA407876, AA409940, AA960376, ASY, C130026I10Rik, NOGO, NSP-CL, NgA, Nogo-A, Nogo-B, Nogo-C, mKIAA0886, mKIAA4153 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020178 68585 Rtn4 http://www.ncbi.nlm.nih.gov/gene/?term=68585 "1110020G17Rik, AA407876, AA409940, AA960376, ASY, C130026I10Rik, NOGO, NSP-CL, NgA, Nogo-A, Nogo-B, Nogo-C, mKIAA0886, mKIAA4153 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020179 68588 Cthrc1 http://www.ncbi.nlm.nih.gov/gene/?term=68588 1110014B07Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020180 68603 Pmvk http://www.ncbi.nlm.nih.gov/gene/?term=68603 "1110011E12Rik, 2900002L22Rik, AV001327, PMK, PMKA, PMKASE " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020181 68611 Mrpl28 http://www.ncbi.nlm.nih.gov/gene/?term=68611 "1110015G04Rik, L28mt, MAAT1, MRP-L28, p15 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020182 6861 SYT5 http://www.ncbi.nlm.nih.gov/gene/?term=6861 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020183 68646 Nadk2 http://www.ncbi.nlm.nih.gov/gene/?term=68646 "MNADK, Nadkd1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020184 68652 Tab2 http://www.ncbi.nlm.nih.gov/gene/?term=68652 "1110030N06Rik, A530078N03Rik, Map3k7ip2, mKIAA0733 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020185 68666 Svop http://www.ncbi.nlm.nih.gov/gene/?term=68666 "1110030H18Rik, AI415691, msvop " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020186 6866 TAC3 http://www.ncbi.nlm.nih.gov/gene/?term=6866 "HH10, NKB, NKNB, PRO1155, ZNEUROK1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020187 6867 TACC1 http://www.ncbi.nlm.nih.gov/gene/?term=6867 Ga55 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020188 6867 TACC1 http://www.ncbi.nlm.nih.gov/gene/?term=6867 Ga55 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020189 68684 1110035D15Rik http://www.ncbi.nlm.nih.gov/gene/?term=68684 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020190 6868 ADAM17 http://www.ncbi.nlm.nih.gov/gene/?term=6868 "ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020191 6868 ADAM17 http://www.ncbi.nlm.nih.gov/gene/?term=6868 "ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020192 68693 Hnrnpul2 http://www.ncbi.nlm.nih.gov/gene/?term=68693 "1110031M08Rik, AI465155, Hnrpul2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020193 68695 Hddc3 http://www.ncbi.nlm.nih.gov/gene/?term=68695 "1110033O09Rik, C86475, MESH1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020194 6869 TACR1 http://www.ncbi.nlm.nih.gov/gene/?term=6869 "NK1R, NKIR, SPR, TAC1R " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020195 686 BTD http://www.ncbi.nlm.nih.gov/gene/?term=686 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020196 686 BTD http://www.ncbi.nlm.nih.gov/gene/?term=686 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020197 68718 Rnf166 http://www.ncbi.nlm.nih.gov/gene/?term=68718 "1110031E24Rik, AW555115, Zfp313l " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020198 68724 Arl8a http://www.ncbi.nlm.nih.gov/gene/?term=68724 "1110033P22Rik, Arl10b, gie2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020199 6872 TAF1 http://www.ncbi.nlm.nih.gov/gene/?term=6872 "BA2R, CCG1, CCGS, DYT3, DYT3/TAF1, KAT4, MRXS33, N-TAF1, NSCL2, OF, P250, TAF(II)250, TAF2A, TAFII-250, TAFII250, XDP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020200 68734 Smek1 http://www.ncbi.nlm.nih.gov/gene/?term=68734 "1110034C04Rik, BC064465, Ppp4r3a, mKIAA2010 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020201 68736 Tyw5 http://www.ncbi.nlm.nih.gov/gene/?term=68736 1110034B05Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020202 6873 TAF2 http://www.ncbi.nlm.nih.gov/gene/?term=6873 "CIF150, MRT40B, TAFII150, TAF2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020203 6873 TAF2 http://www.ncbi.nlm.nih.gov/gene/?term=6873 "CIF150, MRT40, TAF2B, TAFII150 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020204 6874 TAF4 http://www.ncbi.nlm.nih.gov/gene/?term=6874 "TAF2C, TAF2C1A, TAFII130, TAFII135, TAF4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020205 6874 TAF4 http://www.ncbi.nlm.nih.gov/gene/?term=6874 "TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020206 68763 1110038B12Rik http://www.ncbi.nlm.nih.gov/gene/?term=68763 "0610009C20Rik, 0910001G04Rik " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020207 68767 Wash1 http://www.ncbi.nlm.nih.gov/gene/?term=68767 "1110049F14Rik, ORF19, Wash " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020208 6876 TAGLN http://www.ncbi.nlm.nih.gov/gene/?term=6876 "SM22, SMCC, TAGLN1, WS3-10 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020209 68770 Phtf2 http://www.ncbi.nlm.nih.gov/gene/?term=68770 "1110054G21Rik, 9530062N20Rik, AI447096, C77923 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020210 68775 Atp6v1c2 http://www.ncbi.nlm.nih.gov/gene/?term=68775 1110038G14Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020211 68786 1110059G02Rik http://www.ncbi.nlm.nih.gov/gene/?term=68786 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020212 6878 TAF6 http://www.ncbi.nlm.nih.gov/gene/?term=6878 "MGC:8964, TAF(II)70, TAF(II)80, TAF2E, TAFII-70, TAFII-80, TAFII70, TAFII80, TAFII85 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020213 68792 Srpx2 http://www.ncbi.nlm.nih.gov/gene/?term=68792 "1110039C07Rik, SRP, SRPUL " mRNA Rattus norvegicus 10618370 Nucleolus Fibroblast|NRK cell In situ hybridization "Additionally, SRP RNA is a member of a family of small nonribosomal RNAs found recently in the nucleolus, suggesting that the nucleolus is more plurifunctional than previously realized. These results demonstrate that SRP RNA and three SRP proteins visit the nucleolus, suggesting that partial SRP assembly, or another unidentified activity of the SRP components, occurs at the nucleolus. " RLID00020214 68795 Ubr3 http://www.ncbi.nlm.nih.gov/gene/?term=68795 "1110059H15Rik, 4833421P10Rik, A130030D10Rik, AA409735, AA414972, AA422631, AI646861, AU016126, Zfp650, Znf650 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020215 6879 TAF7 http://www.ncbi.nlm.nih.gov/gene/?term=6879 "TAF2F, TAFII55 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020216 6879 TAF7 http://www.ncbi.nlm.nih.gov/gene/?term=6879 "TAF2F, TAFII55 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020217 6879 TAF7 http://www.ncbi.nlm.nih.gov/gene/?term=6879 "TAF2F, TAFII55 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020218 687 KLF9 http://www.ncbi.nlm.nih.gov/gene/?term=687 "BTEB, BTEB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020219 68801 Elovl5 http://www.ncbi.nlm.nih.gov/gene/?term=68801 "1110059L23Rik, AI747313, AU043003, HELO1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020220 68817 Ddi2 http://www.ncbi.nlm.nih.gov/gene/?term=68817 "1110056G13Rik, 1700027M01Rik, 9130022E05Rik, AI604911, AU040698 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020221 6881 TAF10 http://www.ncbi.nlm.nih.gov/gene/?term=6881 "TAF2A, TAF2H, TAFII30 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020222 6881 TAF10 http://www.ncbi.nlm.nih.gov/gene/?term=6881 "TAF2A, TAF2H, TAFII30 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020223 6881 TAF10 http://www.ncbi.nlm.nih.gov/gene/?term=6881 "TAF2A, TAF2H, TAFII30 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020224 6882 TAF11 http://www.ncbi.nlm.nih.gov/gene/?term=6882 "MGC:15243, PRO2134, TAF2I, TAFII28 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020225 6882 TAF11 http://www.ncbi.nlm.nih.gov/gene/?term=6882 "MGC:15243, PRO2134, TAF2I, TAFII28 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020226 68832 Ldah http://www.ncbi.nlm.nih.gov/gene/?term=68832 "1110057K04Rik, mLDAH " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020227 68837 Foxk2 http://www.ncbi.nlm.nih.gov/gene/?term=68837 "1110054H05Rik, 5730434B08Rik, 6230415M23Rik, ILF, Ilf1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020228 6883 TAF12 http://www.ncbi.nlm.nih.gov/gene/?term=6883 "TAF2J, TAFII20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020229 6883 TAF12 http://www.ncbi.nlm.nih.gov/gene/?term=6883 "TAF2J, TAFII20 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020230 6883 TAF12 http://www.ncbi.nlm.nih.gov/gene/?term=6883 "TAF2J, TAFII20 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020231 68842 Tulp4 http://www.ncbi.nlm.nih.gov/gene/?term=68842 "1110057P05Rik, 2210038L17Rik, Tusp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020232 68846 Rnf208 http://www.ncbi.nlm.nih.gov/gene/?term=68846 1110061N23Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020233 6884 TAF13 http://www.ncbi.nlm.nih.gov/gene/?term=6884 "TAF(II)18, TAF2K, TAFII-18, TAFII18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020234 68859 Smim1 http://www.ncbi.nlm.nih.gov/gene/?term=68859 "0610011H04Rik, 1190007F08Rik, 2700009I11Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020235 6885 MAP3K7 http://www.ncbi.nlm.nih.gov/gene/?term=6885 "MEKK7, TAK1, TGF1a " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020236 6885 MAP3K7 http://www.ncbi.nlm.nih.gov/gene/?term=6885 "MEKK7, TAK1, TGF1a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020237 6886 TAL1 http://www.ncbi.nlm.nih.gov/gene/?term=6886 "SCL, TCL5, bHLHa17, tal-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020238 6888 TALDO1 http://www.ncbi.nlm.nih.gov/gene/?term=6888 "TAL, TAL-H, TALDOR, TALH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020239 688 KLF5 http://www.ncbi.nlm.nih.gov/gene/?term=688 "BTEB2, CKLF, IKLF " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020240 688 KLF5 http://www.ncbi.nlm.nih.gov/gene/?term=688 "BTEB2, CKLF, IKLF " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00020241 68904 Abhd13 http://www.ncbi.nlm.nih.gov/gene/?term=68904 "1110065L07Rik, AI463703, AI788994 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020242 68905 1110065H08Rik http://www.ncbi.nlm.nih.gov/gene/?term=68905 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020243 689064 LOC689064 http://www.ncbi.nlm.nih.gov/gene/?term=689064 mRNA Rattus norvegicus 19003354 Ribosome Fibroblast Hybridisation|Northern blot Globin transcripts with the native globin 3'untranslated region or with the 3'untranslated region of c-myc are present in free/cytoskeletal-bound polysomes. RLID00020244 6890 TAP1 http://www.ncbi.nlm.nih.gov/gene/?term=6890 "ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4*0102N, TAP1N, TAP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020245 6890 TAP1 http://www.ncbi.nlm.nih.gov/gene/?term=6890 "ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4*0102N, TAP1N, TAP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020246 6890 TAP1 http://www.ncbi.nlm.nih.gov/gene/?term=6890 "ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020247 68917 Hint2 http://www.ncbi.nlm.nih.gov/gene/?term=68917 1190005L05Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020248 68918 1190005I06Rik http://www.ncbi.nlm.nih.gov/gene/?term=68918 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020249 6891 TAP2 http://www.ncbi.nlm.nih.gov/gene/?term=6891 "ABC18, ABCB3, APT2, D6S217E, PSF-2, PSF2, RING11 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020250 68927 Ptcd2 http://www.ncbi.nlm.nih.gov/gene/?term=68927 1190005P08Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020251 68929 Mospd3 http://www.ncbi.nlm.nih.gov/gene/?term=68929 "1190005J19Rik, 5133401H10Rik, Gtig2, R124 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020252 6892 TAPBP http://www.ncbi.nlm.nih.gov/gene/?term=6892 "NGS17, TAPA, TPN, TPSN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020253 6892 TAPBP http://www.ncbi.nlm.nih.gov/gene/?term=6892 "NGS17, TAPA, TPN, TPSN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020254 6892 TAPBP http://www.ncbi.nlm.nih.gov/gene/?term=6892 "NGS17, TAPA, TPN, TPSN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020255 6892 TAPBP http://www.ncbi.nlm.nih.gov/gene/?term=6892 "NGS17, TAPA, TPN, TPSN " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020256 68938 Aspscr1 http://www.ncbi.nlm.nih.gov/gene/?term=68938 "1190006K01Rik, ASPC, ASPCR1, ASPL, ASPS, RCC17, TUG " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020257 68943 Pink1 http://www.ncbi.nlm.nih.gov/gene/?term=68943 "1190006F07Rik, AU042772, AW557854, BRPK, mFLJ00387 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020258 68944 Tmco1 http://www.ncbi.nlm.nih.gov/gene/?term=68944 "1190006A08Rik, 4930403O06Rik, AA109065, AU022572, ESTM39 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020259 68949 Zfos1 http://www.ncbi.nlm.nih.gov/gene/?term=68949 "1500012F01Rik, Zfas1 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020260 68952 Fam57b http://www.ncbi.nlm.nih.gov/gene/?term=68952 "1500016O10Rik, A330104J06Rik, AI413816, AW060769 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020261 6895 TARBP2 http://www.ncbi.nlm.nih.gov/gene/?term=6895 "LOQS, TRBP, TRBP1, TRBP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020262 68964 Ctc1 http://www.ncbi.nlm.nih.gov/gene/?term=68964 "1500010J02Rik, AAF-132, AAF132 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020263 68966 Ngdn http://www.ncbi.nlm.nih.gov/gene/?term=68966 "1500001L15Rik, Ngd, neuroguidin " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020264 68968 Cdan1 http://www.ncbi.nlm.nih.gov/gene/?term=68968 "1500015A01Rik, AI448026, AW492297, CDA-I, CDA1, CDAI " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020265 68975 Med27 http://www.ncbi.nlm.nih.gov/gene/?term=68975 "1500015J03Rik, 2310042P07Rik, AA682045, Crsp8, D2Ertd434e " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020266 6897 TARS http://www.ncbi.nlm.nih.gov/gene/?term=6897 ThrRS mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020267 68982 1500015A07Rik http://www.ncbi.nlm.nih.gov/gene/?term=68982 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020268 6898 TAT http://www.ncbi.nlm.nih.gov/gene/?term=6898 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020269 6898 TAT http://www.ncbi.nlm.nih.gov/gene/?term=6898 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020270 68992 Zfp580 http://www.ncbi.nlm.nih.gov/gene/?term=68992 "1500015O20Rik, AI838225, Znf580 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020271 68995 Mcts1 http://www.ncbi.nlm.nih.gov/gene/?term=68995 "1500019M23Rik, MCT-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020272 689 BTF3 http://www.ncbi.nlm.nih.gov/gene/?term=689 "BETA-NACa, BTF3b, NACB, BTF3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020273 689 BTF3 http://www.ncbi.nlm.nih.gov/gene/?term=689 "BETA-NAC, BTF3a, BTF3b, NACB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020274 69002 1500026H17Rik http://www.ncbi.nlm.nih.gov/gene/?term=69002 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020275 69009 Thap7 http://www.ncbi.nlm.nih.gov/gene/?term=69009 1810004B07Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020276 6901 TAZ http://www.ncbi.nlm.nih.gov/gene/?term=6901 "BTHS, CMD3A, EFE, EFE2, G4.5, LVNCX, Taz1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020277 6901 TAZ http://www.ncbi.nlm.nih.gov/gene/?term=6901 "BTHS, CMD3A, EFE, EFE2, G4.5, LVNCX, Taz1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020278 69025 1500032P08Rik http://www.ncbi.nlm.nih.gov/gene/?term=69025 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020279 6902 TBCA http://www.ncbi.nlm.nih.gov/gene/?term=6902 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020280 6902 TBCA http://www.ncbi.nlm.nih.gov/gene/?term=6902 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020281 6902 TBCA http://www.ncbi.nlm.nih.gov/gene/?term=6902 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020282 69034 Nupr1l http://www.ncbi.nlm.nih.gov/gene/?term=69034 "1810010E01Rik, 4930579G22Rik, Nupr2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020283 69036 Zg16 http://www.ncbi.nlm.nih.gov/gene/?term=69036 "1810010M01Rik, AI593689, ZG16p " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020284 6903 TBCC http://www.ncbi.nlm.nih.gov/gene/?term=6903 CFC mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020285 69048 Slc30a5 http://www.ncbi.nlm.nih.gov/gene/?term=69048 "1810010K08Rik, AF233321, ZNT5, ZTL1, ZnT-5, Zntl1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020286 6904 TBCD http://www.ncbi.nlm.nih.gov/gene/?term=6904 "SSD-1, tfcD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020287 69051 Pycr2 http://www.ncbi.nlm.nih.gov/gene/?term=69051 "1810018M05Rik, P5cr2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020288 69053 1810013L24Rik http://www.ncbi.nlm.nih.gov/gene/?term=69053 "1110017P05Rik, 3010002C02Rik, AA792997, AW124177, Gm19906, R74903 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020289 69064 Fuom http://www.ncbi.nlm.nih.gov/gene/?term=69064 "Fucu, Le51 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020290 69065 Chac1 http://www.ncbi.nlm.nih.gov/gene/?term=69065 1810008K03Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020291 69077 Psmd11 http://www.ncbi.nlm.nih.gov/gene/?term=69077 "1700089D09Rik, 1810019E17Rik, 2610024G20Rik, 2810055C24Rik, C78232, P44.5, S9 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020292 6907 TBL1X http://www.ncbi.nlm.nih.gov/gene/?term=6907 "EBI, SMAP55, TBL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020293 69080 Gmppa http://www.ncbi.nlm.nih.gov/gene/?term=69080 1810012N01Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020294 69082 Zc3h15 http://www.ncbi.nlm.nih.gov/gene/?term=69082 "1700006A17Rik, 1810012H02Rik, 2610312B22Rik, FM22, Ierepo4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020295 69085 Zcchc9 http://www.ncbi.nlm.nih.gov/gene/?term=69085 1810019C21Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020296 6908 TBP http://www.ncbi.nlm.nih.gov/gene/?term=6908 "GTF2D, GTF2D1, HDL4, SCA17, TFIID " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020297 69090 Ascc1 http://www.ncbi.nlm.nih.gov/gene/?term=69090 "1810015P09Rik, AI550520, ASC1p50, CGI-18 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020298 69091 Vps26b http://www.ncbi.nlm.nih.gov/gene/?term=69091 "1810012I05Rik, 2310075A12Rik, AI848392 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020299 69094 Tmem160 http://www.ncbi.nlm.nih.gov/gene/?term=69094 1810008O21Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020300 6909 TBX2 http://www.ncbi.nlm.nih.gov/gene/?term=6909 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020301 69116 Ubr4 http://www.ncbi.nlm.nih.gov/gene/?term=69116 "1810009A16Rik, A930005E13Rik, D930005K06Rik, Gm1032, Gm1666, N28143, RBAF600, Zubr1, mKIAA0462, p600 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020302 69131 Cdk12 http://www.ncbi.nlm.nih.gov/gene/?term=69131 "1810022J16Rik, AI646528, Crk7, Crkrs, D11Ertd752e, Pksc " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020303 69137 Vstm5 http://www.ncbi.nlm.nih.gov/gene/?term=69137 2200002K05Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020304 691393 Oxa1l http://www.ncbi.nlm.nih.gov/gene/?term=691393 mRNA Rattus norvegicus 15485813 Ribosome Hepatoma cell qRT-PCR "In agreement with previous studies, oxa1 mRNA was associated with the mitochondria-bound polysomes but unlike ucp2, oxa1 transcript did not bind K protein. " RLID00020305 69149 Kbtbd3 http://www.ncbi.nlm.nih.gov/gene/?term=69149 "2200003A07Rik, Bklhd3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020306 69156 Comtd1 http://www.ncbi.nlm.nih.gov/gene/?term=69156 "1810030M08Rik, MT773 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020307 69159 Rhebl1 http://www.ncbi.nlm.nih.gov/gene/?term=69159 "1810036J22Rik, Rheb2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020308 6915 TBXA2R http://www.ncbi.nlm.nih.gov/gene/?term=6915 "BDPLT13, TXA2-R " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020309 6915 TBXA2R http://www.ncbi.nlm.nih.gov/gene/?term=6915 "BDPLT13, TXA2-R " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020310 6915 TBXA2R http://www.ncbi.nlm.nih.gov/gene/?term=6915 "BDPLT13, TXA2-R " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020311 69168 Bola1 http://www.ncbi.nlm.nih.gov/gene/?term=69168 1810037G04Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020312 6916 TBXAS1 http://www.ncbi.nlm.nih.gov/gene/?term=6916 "BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020313 6917 TCEA1 http://www.ncbi.nlm.nih.gov/gene/?term=6917 "GTF2S, SII, TCEA, TF2S, TFIIS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020314 6917 TCEA1 http://www.ncbi.nlm.nih.gov/gene/?term=6917 "GTF2S, SII, TCEA, TF2S, TFIIS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020315 69181 Dyrk2 http://www.ncbi.nlm.nih.gov/gene/?term=69181 1810038L18Rik lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020316 69181 Dyrk2 http://www.ncbi.nlm.nih.gov/gene/?term=69181 1810038L18Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020317 69186 Tmem256 http://www.ncbi.nlm.nih.gov/gene/?term=69186 "1810027O10Rik, 3110009M16Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020318 69188 Kmt2e http://www.ncbi.nlm.nih.gov/gene/?term=69188 "1810033J14Rik, 9530077A04Rik, D230038D11Rik, Mll5, NKp44L " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020319 69188 Kmt2e http://www.ncbi.nlm.nih.gov/gene/?term=69188 "1810033J14Rik, 9530077A04Rik, D230038D11Rik, Mll5, NKp44L " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020320 69195 Tmem121 http://www.ncbi.nlm.nih.gov/gene/?term=69195 "2410008J05Rik, Hole " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020321 6919 TCEA2 http://www.ncbi.nlm.nih.gov/gene/?term=6919 TFIIS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020322 69202 Ptms http://www.ncbi.nlm.nih.gov/gene/?term=69202 2610009E16Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020323 692053 SNORD9 http://www.ncbi.nlm.nih.gov/gene/?term=692053 mgU6-53B snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020324 692057 SNORD12 http://www.ncbi.nlm.nih.gov/gene/?term=692057 "HBII-99, MIR1259, MIRN1259 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020325 692058 SNORD11 http://www.ncbi.nlm.nih.gov/gene/?term=692058 HBII-95 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020326 692075 SNORD6 http://www.ncbi.nlm.nih.gov/gene/?term=692075 mgh28S-2412 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020327 692075 SNORD6 http://www.ncbi.nlm.nih.gov/gene/?term=692075 mgh28S-2412 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020328 692076 SNORD7 http://www.ncbi.nlm.nih.gov/gene/?term=692076 "Z30, mgU6-47 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020329 692076 SNORD7 http://www.ncbi.nlm.nih.gov/gene/?term=692076 "Z30, mgU6-47 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020330 692076 SNORD7 http://www.ncbi.nlm.nih.gov/gene/?term=692076 "Z30, mgU6-47 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020331 69207 Srsf11 http://www.ncbi.nlm.nih.gov/gene/?term=69207 "0610009J05Rik, 2610019N13Rik, BF642805, Sfrs11 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020332 692084 SNORD13 http://www.ncbi.nlm.nih.gov/gene/?term=692084 "RNU13A, U13, SNORD13 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020333 692084 SNORD13 http://www.ncbi.nlm.nih.gov/gene/?term=692084 "RNU13A, U13, SNORD13 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020334 692085 SNORD45C http://www.ncbi.nlm.nih.gov/gene/?term=692085 U45C snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020335 692086 SNORD17 http://www.ncbi.nlm.nih.gov/gene/?term=692086 HBI-43 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020336 692086 SNORD17 http://www.ncbi.nlm.nih.gov/gene/?term=692086 HBI-43 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020337 692089 SNORD19 http://www.ncbi.nlm.nih.gov/gene/?term=692089 HBII-108 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020338 692090 SNORD59B http://www.ncbi.nlm.nih.gov/gene/?term=692090 U59B snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020339 692090 SNORD59B http://www.ncbi.nlm.nih.gov/gene/?term=692090 U59B snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020340 692093 SNORD62B http://www.ncbi.nlm.nih.gov/gene/?term=692093 "U62, U62B " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020341 692093 SNORD62B http://www.ncbi.nlm.nih.gov/gene/?term=692093 "U62, U62B " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020342 692093 SNORD62B http://www.ncbi.nlm.nih.gov/gene/?term=692093 "U62, U62B " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020343 692093 SNORD62B http://www.ncbi.nlm.nih.gov/gene/?term=692093 "U62, U62B " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020344 6920 TCEA3 http://www.ncbi.nlm.nih.gov/gene/?term=6920 "TFIIS, TFIIS.H " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020345 692106 SNORD65 http://www.ncbi.nlm.nih.gov/gene/?term=692106 "HBII-135A, SNORD65 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00020346 692107 SNORD66 http://www.ncbi.nlm.nih.gov/gene/?term=692107 HBII-142 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020347 692107 SNORD66 http://www.ncbi.nlm.nih.gov/gene/?term=692107 HBII-142 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020348 692107 SNORD66 http://www.ncbi.nlm.nih.gov/gene/?term=692107 HBII-142 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020349 692107 SNORD66 http://www.ncbi.nlm.nih.gov/gene/?term=692107 HBII-142 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020350 692107 SNORD66 http://www.ncbi.nlm.nih.gov/gene/?term=692107 HBII-142 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020351 692108 SNORD67 http://www.ncbi.nlm.nih.gov/gene/?term=692108 HBII-166 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00020352 692108 SNORD67 http://www.ncbi.nlm.nih.gov/gene/?term=692108 HBII-166 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020353 692109 SNORD69 http://www.ncbi.nlm.nih.gov/gene/?term=692109 HBII-210 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020354 692109 SNORD69 http://www.ncbi.nlm.nih.gov/gene/?term=692109 HBII-210 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020355 692110 SNORD70 http://www.ncbi.nlm.nih.gov/gene/?term=692110 "HBII-234A, SNORD70 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020356 692111 SNORD71 http://www.ncbi.nlm.nih.gov/gene/?term=692111 "HBII-239, MIRN768, hsa-mir-768 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020357 692111 SNORD71 http://www.ncbi.nlm.nih.gov/gene/?term=692111 "HBII-239, MIRN768, hsa-mir-768 " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020358 692111 SNORD71 http://www.ncbi.nlm.nih.gov/gene/?term=692111 "HBII-239, MIRN768, hsa-mir-768 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020359 692111 SNORD71 http://www.ncbi.nlm.nih.gov/gene/?term=692111 "HBII-239, MIRN768, hsa-mir-768 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020360 692111 SNORD71 http://www.ncbi.nlm.nih.gov/gene/?term=692111 "HBII-239, MIRN768, hsa-mir-768 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020361 692149 SCARNA14 http://www.ncbi.nlm.nih.gov/gene/?term=692149 U100 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020362 692158 SNORA57 http://www.ncbi.nlm.nih.gov/gene/?term=692158 U99 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00020363 692196 SNORD76 http://www.ncbi.nlm.nih.gov/gene/?term=692196 U76 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00020364 692196 SNORD76 http://www.ncbi.nlm.nih.gov/gene/?term=692196 U76 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020365 692196 SNORD76 http://www.ncbi.nlm.nih.gov/gene/?term=692196 U76 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020366 692197 SNORD77 http://www.ncbi.nlm.nih.gov/gene/?term=692197 "SNORD77A, U77 " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020367 692197 SNORD77 http://www.ncbi.nlm.nih.gov/gene/?term=692197 "SNORD77A, U77 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020368 692197 SNORD77 http://www.ncbi.nlm.nih.gov/gene/?term=692197 "SNORD77A, U77 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020369 692198 SNORD78 http://www.ncbi.nlm.nih.gov/gene/?term=692198 U78 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020370 692198 SNORD78 http://www.ncbi.nlm.nih.gov/gene/?term=692198 U78 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020371 692198 SNORD78 http://www.ncbi.nlm.nih.gov/gene/?term=692198 U78 snoRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 6. Ten Most Highly Expressed snoRNAs of Exosome I, Exosome II and W. Data are collected from Table 6. " RLID00020372 692198 SNORD78 http://www.ncbi.nlm.nih.gov/gene/?term=692198 U78 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020373 692198 SNORD78 http://www.ncbi.nlm.nih.gov/gene/?term=692198 U78 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020374 692199 SNORD84 http://www.ncbi.nlm.nih.gov/gene/?term=692199 U84 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00020375 6921 TCEB1 http://www.ncbi.nlm.nih.gov/gene/?term=6921 "SIII, eloC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020376 6921 TCEB1 http://www.ncbi.nlm.nih.gov/gene/?term=6921 "SIII, eloC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020377 692200 SNORD103C http://www.ncbi.nlm.nih.gov/gene/?term=692200 "HBII-251, SNORD85 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020378 692200 SNORD103C http://www.ncbi.nlm.nih.gov/gene/?term=692200 "HBII-251, SNORD85 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020379 692202 SNORD88A http://www.ncbi.nlm.nih.gov/gene/?term=692202 HBII-180A snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020380 692202 SNORD88A http://www.ncbi.nlm.nih.gov/gene/?term=692202 HBII-180A snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020381 692205 SNORD89 http://www.ncbi.nlm.nih.gov/gene/?term=692205 HBII-289 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00020382 692205 SNORD89 http://www.ncbi.nlm.nih.gov/gene/?term=692205 HBII-289 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020383 692205 SNORD89 http://www.ncbi.nlm.nih.gov/gene/?term=692205 HBII-289 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020384 692205 SNORD89 http://www.ncbi.nlm.nih.gov/gene/?term=692205 HBII-289 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020385 692206 SNORD90 http://www.ncbi.nlm.nih.gov/gene/?term=692206 HBII-295 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020386 692207 SNORD91A http://www.ncbi.nlm.nih.gov/gene/?term=692207 HBII-296a snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020387 692207 SNORD91A http://www.ncbi.nlm.nih.gov/gene/?term=692207 HBII-296a snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020388 692207 SNORD91A http://www.ncbi.nlm.nih.gov/gene/?term=692207 HBII-296a snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020389 692208 SNORD91B http://www.ncbi.nlm.nih.gov/gene/?term=692208 HBII-296b snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020390 692208 SNORD91B http://www.ncbi.nlm.nih.gov/gene/?term=692208 HBII-296b snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020391 692208 SNORD91B http://www.ncbi.nlm.nih.gov/gene/?term=692208 HBII-296b snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020392 692209 SNORD92 http://www.ncbi.nlm.nih.gov/gene/?term=692209 HBII-316 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00020393 692209 SNORD92 http://www.ncbi.nlm.nih.gov/gene/?term=692209 HBII-316 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020394 692210 SNORD93 http://www.ncbi.nlm.nih.gov/gene/?term=692210 HBII-336 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020395 692210 SNORD93 http://www.ncbi.nlm.nih.gov/gene/?term=692210 HBII-336 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020396 692210 SNORD93 http://www.ncbi.nlm.nih.gov/gene/?term=692210 HBII-336 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020397 692210 SNORD93 http://www.ncbi.nlm.nih.gov/gene/?term=692210 HBII-336 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020398 692210 SNORD93 http://www.ncbi.nlm.nih.gov/gene/?term=692210 HBII-336 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020399 692211 SNORD98 http://www.ncbi.nlm.nih.gov/gene/?term=692211 HBII-419 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020400 692211 SNORD98 http://www.ncbi.nlm.nih.gov/gene/?term=692211 HBII-419 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020401 692211 SNORD98 http://www.ncbi.nlm.nih.gov/gene/?term=692211 HBII-419 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020402 692211 SNORD98 http://www.ncbi.nlm.nih.gov/gene/?term=692211 HBII-419 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020403 692212 SNORD99 http://www.ncbi.nlm.nih.gov/gene/?term=692212 HBII-420 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020404 692213 SNORD110 http://www.ncbi.nlm.nih.gov/gene/?term=692213 HBII-55 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020405 692213 SNORD110 http://www.ncbi.nlm.nih.gov/gene/?term=692213 HBII-55 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020406 692223 SNORD97 http://www.ncbi.nlm.nih.gov/gene/?term=692223 U97 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020407 692223 SNORD97 http://www.ncbi.nlm.nih.gov/gene/?term=692223 U97 snoRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 6. Ten Most Highly Expressed snoRNAs of Exosome I, Exosome II and W. Data are collected from Table 6. " RLID00020408 692223 SNORD97 http://www.ncbi.nlm.nih.gov/gene/?term=692223 U97 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020409 692225 SNORD94 http://www.ncbi.nlm.nih.gov/gene/?term=692225 U94 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00020410 692225 SNORD94 http://www.ncbi.nlm.nih.gov/gene/?term=692225 U94 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020411 692225 SNORD94 http://www.ncbi.nlm.nih.gov/gene/?term=692225 U94 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020412 692225 SNORD94 http://www.ncbi.nlm.nih.gov/gene/?term=692225 U94 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020413 692227 SNORD104 http://www.ncbi.nlm.nih.gov/gene/?term=692227 U104 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00020414 692227 SNORD104 http://www.ncbi.nlm.nih.gov/gene/?term=692227 U104 snoRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00020415 692227 SNORD104 http://www.ncbi.nlm.nih.gov/gene/?term=692227 U104 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020416 692227 SNORD104 http://www.ncbi.nlm.nih.gov/gene/?term=692227 U104 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020417 692227 SNORD104 http://www.ncbi.nlm.nih.gov/gene/?term=692227 U104 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020418 692227 SNORD104 http://www.ncbi.nlm.nih.gov/gene/?term=692227 U104 snoRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 6. Ten Most Highly Expressed snoRNAs of Exosome I, Exosome II and W. Data are collected from Table 6. " RLID00020419 692227 SNORD104 http://www.ncbi.nlm.nih.gov/gene/?term=692227 U104 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020420 692227 SNORD104 http://www.ncbi.nlm.nih.gov/gene/?term=692227 U104 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020421 692229 SNORD105 http://www.ncbi.nlm.nih.gov/gene/?term=692229 U105 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020422 692229 SNORD105 http://www.ncbi.nlm.nih.gov/gene/?term=692229 U105 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020423 692229 SNORD105 http://www.ncbi.nlm.nih.gov/gene/?term=692229 U105 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020424 692229 SNORD105 http://www.ncbi.nlm.nih.gov/gene/?term=692229 U105 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020425 692232 SNORD3@ http://www.ncbi.nlm.nih.gov/gene/?term=692232 "U3, U3A, U3B " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020426 692232 SNORD3@ http://www.ncbi.nlm.nih.gov/gene/?term=692232 "U3, U3A, U3B " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020427 692232 SNORD3@ http://www.ncbi.nlm.nih.gov/gene/?term=692232 "U3, U3A, U3B " snoRNA Homo sapiens 25203660 Cytoplasm HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020428 692233 SNORD117 http://www.ncbi.nlm.nih.gov/gene/?term=692233 U83 snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00020429 692233 SNORD117 http://www.ncbi.nlm.nih.gov/gene/?term=692233 U83 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020430 692233 SNORD117 http://www.ncbi.nlm.nih.gov/gene/?term=692233 U83 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00020431 692234 SNORD103A http://www.ncbi.nlm.nih.gov/gene/?term=692234 U103 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020432 69236 2610034E01Rik http://www.ncbi.nlm.nih.gov/gene/?term=69236 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020433 69237 Gtpbp4 http://www.ncbi.nlm.nih.gov/gene/?term=69237 "2610028C09Rik, Crfg, Gtpbp3, NGB, Nog1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020434 6923 TCEB2 http://www.ncbi.nlm.nih.gov/gene/?term=6923 "ELOB, SIII " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020435 6923 TCEB2 http://www.ncbi.nlm.nih.gov/gene/?term=6923 "ELOB, SIII " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020436 69241 Polr2d http://www.ncbi.nlm.nih.gov/gene/?term=69241 "2310002G05Rik, 2610028L19Rik, HSRBP4, RBP4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020437 69253 Hspb2 http://www.ncbi.nlm.nih.gov/gene/?term=69253 "27kDa, 2810021G24Rik, HSP27, MKBP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020438 69257 Elf2 http://www.ncbi.nlm.nih.gov/gene/?term=69257 "2610036A20Rik, A230104O07Rik, AW111824, BB183398, EU32, NERF, NERF-1A, NERF-1B, NERF-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020439 6925 TCF4 http://www.ncbi.nlm.nih.gov/gene/?term=6925 "E2-2, FECD3, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4, bHLHb19 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020440 6925 TCF4 http://www.ncbi.nlm.nih.gov/gene/?term=6925 "E2-2, FECD3, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4, bHLHb19 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020441 69260 Ing2 http://www.ncbi.nlm.nih.gov/gene/?term=69260 "2810011M06Rik, Ing1lb, P33ING2, Ing2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020442 69261 2810411K19Rik http://www.ncbi.nlm.nih.gov/gene/?term=69261 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020443 6926 TBX3 http://www.ncbi.nlm.nih.gov/gene/?term=6926 "TBX3-ISO, UMS, XHL " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020444 69270 Gins1 http://www.ncbi.nlm.nih.gov/gene/?term=69270 "2810418N01Rik, Gins4, PSF1, mKIAA0186 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020445 69276 Sec62 http://www.ncbi.nlm.nih.gov/gene/?term=69276 "3100002M17Rik, AI844545, AW545092, Dtrp1, HTP1, Tloc1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020446 69296 Tmigd3 http://www.ncbi.nlm.nih.gov/gene/?term=69296 "1700001d09rik, 4930578J19Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020447 6929 TCF3 http://www.ncbi.nlm.nih.gov/gene/?term=6929 "E2A, E47, ITF1, TCF-3, VDIR, bHLHb21 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020448 6929 TCF3 http://www.ncbi.nlm.nih.gov/gene/?term=6929 "E2A, E47, ITF1, TCF-3, VDIR, bHLHb21 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020449 6932 TCF7 http://www.ncbi.nlm.nih.gov/gene/?term=6932 TCF-1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020450 69350 1700003G18Rik http://www.ncbi.nlm.nih.gov/gene/?term=69350 2610312K03Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020451 69354 Slc38a4 http://www.ncbi.nlm.nih.gov/gene/?term=69354 "1110012E16Rik, 1700012A18Rik, Ata3, mATA3, mNAT3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020452 6936 GCFC2 http://www.ncbi.nlm.nih.gov/gene/?term=6936 "C2orf3, DNABF, GCF, TCF9 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020453 6936 GCFC2 http://www.ncbi.nlm.nih.gov/gene/?term=6936 "C2orf3, DNABF, GCF, TCF9 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020454 6936 GCFC2 http://www.ncbi.nlm.nih.gov/gene/?term=6936 "C2orf3, DNABF, GCF, TCF9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020455 69371 Smco2 http://www.ncbi.nlm.nih.gov/gene/?term=69371 1700023A16Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020456 69372 Mocs3 http://www.ncbi.nlm.nih.gov/gene/?term=69372 "1700020H17Rik, Uba4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020457 6938 TCF12 http://www.ncbi.nlm.nih.gov/gene/?term=6938 "CRS3, HEB, HTF4, HsT17266, TCF-12, bHLHb20 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020458 6938 TCF12 http://www.ncbi.nlm.nih.gov/gene/?term=6938 "CRS3, HEB, HTF4, HsT17266, TCF-12, bHLHb20 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020459 69421 1700022F17Rik http://www.ncbi.nlm.nih.gov/gene/?term=69421 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020460 69423 1700019M22Rik http://www.ncbi.nlm.nih.gov/gene/?term=69423 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020461 6942 TCF20 http://www.ncbi.nlm.nih.gov/gene/?term=6942 "AR1, SPBP, TCF-20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020462 69440 Dennd6b http://www.ncbi.nlm.nih.gov/gene/?term=69440 "1700027J05Rik, AI414881, Fam116b " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020463 69449 1700027A15Rik http://www.ncbi.nlm.nih.gov/gene/?term=69449 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020464 6944 VPS72 http://www.ncbi.nlm.nih.gov/gene/?term=6944 "CFL1, Swc2, TCFL1, YL-1, YL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020465 6944 VPS72 http://www.ncbi.nlm.nih.gov/gene/?term=6944 "CFL1, Swc2, TCFL1, YL-1, YL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020466 69459 Ubl7 http://www.ncbi.nlm.nih.gov/gene/?term=69459 2300004C15Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020467 6945 MLX http://www.ncbi.nlm.nih.gov/gene/?term=6945 "MAD7, MXD7, TCFL4, bHLHd13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020468 6945 MLX http://www.ncbi.nlm.nih.gov/gene/?term=6945 "MAD7, MXD7, TCFL4, bHLHd13 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020469 6945 MLX http://www.ncbi.nlm.nih.gov/gene/?term=6945 "MAD7, MXD7, TCFL4, bHLHd13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020470 69478 2300009A05Rik http://www.ncbi.nlm.nih.gov/gene/?term=69478 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020471 6947 TCN1 http://www.ncbi.nlm.nih.gov/gene/?term=6947 "HC, TC-1, TC1, TCI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020472 69480 Ttc9 http://www.ncbi.nlm.nih.gov/gene/?term=69480 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020473 69489 2310007J06Rik http://www.ncbi.nlm.nih.gov/gene/?term=69489 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020474 6948 TCN2 http://www.ncbi.nlm.nih.gov/gene/?term=6948 "D22S676, D22S750, II, TC, TC II, TC-2, TC2, TCII " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020475 6949 TCOF1 http://www.ncbi.nlm.nih.gov/gene/?term=6949 "MFD1, TCS, TCS1, treacle " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020476 6949 TCOF1 http://www.ncbi.nlm.nih.gov/gene/?term=6949 "MFD1, TCS, TCS1, treacle " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020477 694 BTG1 http://www.ncbi.nlm.nih.gov/gene/?term=694 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020478 694 BTG1 http://www.ncbi.nlm.nih.gov/gene/?term=694 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020479 69534 Avpi1 http://www.ncbi.nlm.nih.gov/gene/?term=69534 "2310008N12Rik, AA410041, VIT32, esu, mVIT32 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020480 69539 Trnp1 http://www.ncbi.nlm.nih.gov/gene/?term=69539 "2300002D11Rik, Trnp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020481 69546 Mapk1ip1 http://www.ncbi.nlm.nih.gov/gene/?term=69546 "2310009E07Rik, AU043776, MISS " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020482 69587 Pcgf3 http://www.ncbi.nlm.nih.gov/gene/?term=69587 "2310035N15Rik, AI662857, D630042K08Rik, DONG1, E430039C14, RNF3A, Rnf3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020483 69617 Pitrm1 http://www.ncbi.nlm.nih.gov/gene/?term=69617 "2310012C15Rik, AA410010, MP-1, MP1, Ntup1, PreP, mKIAA1104 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020484 69632 Arhgef12 http://www.ncbi.nlm.nih.gov/gene/?term=69632 "2310014B11Rik, AU019857, Larg, mKIAA0382 " mRNA Mus musculus 18164504 Cell body Hippocampus RT-PCR "In hippocampal neurons, IQ-ArfGEF/BRAG1 mRNA was localized not only at neuronal cell bodies but also at dendritic processes, indicating its dendritic transport and localization. " RLID00020485 69632 Arhgef12 http://www.ncbi.nlm.nih.gov/gene/?term=69632 "2310014B11Rik, AU019857, Larg, mKIAA0382 " mRNA Mus musculus 18164504 Dendrite Hippocampus RT-PCR "In hippocampal neurons, IQ-ArfGEF/BRAG1 mRNA was localized not only at neuronal cell bodies but also at dendritic processes, indicating its dendritic transport and localization. " RLID00020486 69634 Clybl http://www.ncbi.nlm.nih.gov/gene/?term=69634 "0610033J05Rik, 2310014M14Rik, AI256068, Clb " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020487 69672 Txndc15 http://www.ncbi.nlm.nih.gov/gene/?term=69672 "2310047H23Rik, AI854086, C5orf14, UNQ335 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020488 69675 Pxdn http://www.ncbi.nlm.nih.gov/gene/?term=69675 "2310075M15Rik, C85409, E330004E07, VPO1, mKIAA0230 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020489 69678 Atcayos http://www.ncbi.nlm.nih.gov/gene/?term=69678 2310050B05Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020490 69694 Tatdn1 http://www.ncbi.nlm.nih.gov/gene/?term=69694 "2310079P03Rik, CDA11 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020491 69713 Pin4 http://www.ncbi.nlm.nih.gov/gene/?term=69713 "2410002I22Rik, EPVH, Par14 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020492 69714 Tfpt http://www.ncbi.nlm.nih.gov/gene/?term=69714 "2400004F01Rik, AI450389, Amida, FB1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020493 69716 Trip13 http://www.ncbi.nlm.nih.gov/gene/?term=69716 "2410002G23Rik, D13Ertd328e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020494 69723 Rpain http://www.ncbi.nlm.nih.gov/gene/?term=69723 "2400006N03Rik, Rip " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020495 69724 Rnaseh2a http://www.ncbi.nlm.nih.gov/gene/?term=69724 "2400006P09Rik, RNASEHI, RNHIA, RNHL " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020496 69731 Gemin7 http://www.ncbi.nlm.nih.gov/gene/?term=69731 "2400008I04Rik, AI120175, AI461688 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020497 69745 Pold4 http://www.ncbi.nlm.nih.gov/gene/?term=69745 "2410012M21Rik, AI463381, AW060307, Polds, p12 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020498 69749 Epb41l4aos http://www.ncbi.nlm.nih.gov/gene/?term=69749 "2410004N09Rik, Epb4.1l4aos " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020499 69757 Leng1 http://www.ncbi.nlm.nih.gov/gene/?term=69757 1500001K17Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020500 69772 Bdh2 http://www.ncbi.nlm.nih.gov/gene/?term=69772 "1810026B04Rik, Dhrs6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020501 69774 Ms4a6b http://www.ncbi.nlm.nih.gov/gene/?term=69774 1810027D10Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020502 69786 Tprkb http://www.ncbi.nlm.nih.gov/gene/?term=69786 "0610033G21Rik, 1810034M08Rik, Cgi-121, DRWMS1, mDRWMS1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020503 69798 1810044D09Rik http://www.ncbi.nlm.nih.gov/gene/?term=69798 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020504 69816 Mzb1 http://www.ncbi.nlm.nih.gov/gene/?term=69816 "2010001M09Rik, AV064572, PACAP, pERp1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020505 69829 2010001K21Rik http://www.ncbi.nlm.nih.gov/gene/?term=69829 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020506 69863 Ttc39b http://www.ncbi.nlm.nih.gov/gene/?term=69863 "1810054D07Rik, 9130422G05Rik, AI450603, AV103077, AW215585 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020507 69871 Ppp1r35 http://www.ncbi.nlm.nih.gov/gene/?term=69871 "2010007H12Rik, 2010011D20Rik, AL024004 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020508 69876 Thap3 http://www.ncbi.nlm.nih.gov/gene/?term=69876 "2010013E08Rik, 2210418H06Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020509 69885 Aunip http://www.ncbi.nlm.nih.gov/gene/?term=69885 "2610002D18Rik, Clhc1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020510 69887 2010100M03Rik http://www.ncbi.nlm.nih.gov/gene/?term=69887 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020511 6988 TCTA http://www.ncbi.nlm.nih.gov/gene/?term=6988 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020512 69895 Snhg8 http://www.ncbi.nlm.nih.gov/gene/?term=69895 "1110065M07Rik, 2010109N14Rik " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020513 6990 DYNLT3 http://www.ncbi.nlm.nih.gov/gene/?term=6990 "RP3, TCTE1L, TCTEX1L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020514 6990 DYNLT3 http://www.ncbi.nlm.nih.gov/gene/?term=6990 "RP3, TCTE1L, TCTEX1L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020515 69917 Nabp2 http://www.ncbi.nlm.nih.gov/gene/?term=69917 "2610036N15Rik, Obfc2b " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020516 69920 Polr2i http://www.ncbi.nlm.nih.gov/gene/?term=69920 2810002B19Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020517 69922 Vrk2 http://www.ncbi.nlm.nih.gov/gene/?term=69922 "2810003O05Rik, AI447698 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020518 6992 PPP1R11 http://www.ncbi.nlm.nih.gov/gene/?term=6992 "CFAP255, HCG-V, HCGV, IPP3, TCTE5, TCTEX5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020519 6992 PPP1R11 http://www.ncbi.nlm.nih.gov/gene/?term=6992 "CFAP255, HCG-V, HCGV, IPP3, TCTE5, TCTEX5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020520 6993 DYNLT1 http://www.ncbi.nlm.nih.gov/gene/?term=6993 "CW-1, TCTEL1, tctex-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020521 69955 Fars2 http://www.ncbi.nlm.nih.gov/gene/?term=69955 "Fars1, pheRS " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020522 69957 Cdc16 http://www.ncbi.nlm.nih.gov/gene/?term=69957 "2700071J12Rik, 2810431D22Rik, APC6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020523 69961 Rpp25l http://www.ncbi.nlm.nih.gov/gene/?term=69961 "2810432D09Rik, AW987258, Rppl25 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020524 69968 2810404F17Rik http://www.ncbi.nlm.nih.gov/gene/?term=69968 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020525 6996 TDG http://www.ncbi.nlm.nih.gov/gene/?term=6996 hTDG mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020526 6997 TDGF1 http://www.ncbi.nlm.nih.gov/gene/?term=6997 "CR, CRGF, CRIPTO " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020527 69981 Tmem30a http://www.ncbi.nlm.nih.gov/gene/?term=69981 "2010200I23Rik, AW540225, Cdc50a, D9Wsu20e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020528 69986 1700025N23Rik http://www.ncbi.nlm.nih.gov/gene/?term=69986 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020529 69987 1700026L06Rik http://www.ncbi.nlm.nih.gov/gene/?term=69987 MAST mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020530 699 BUB1 http://www.ncbi.nlm.nih.gov/gene/?term=699 "BUB1AL, hBUB1, BUB1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020531 699 BUB1 http://www.ncbi.nlm.nih.gov/gene/?term=699 "BUB1A, BUB1L, hBUB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020532 70002 1700028E11Rik http://www.ncbi.nlm.nih.gov/gene/?term=70002 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020533 70009 Ssty2 http://www.ncbi.nlm.nih.gov/gene/?term=70009 "1700029H17Rik, pc11 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020534 7001 PRDX2 http://www.ncbi.nlm.nih.gov/gene/?term=7001 "HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020535 7001 PRDX2 http://www.ncbi.nlm.nih.gov/gene/?term=7001 "HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020536 7001 PRDX2 http://www.ncbi.nlm.nih.gov/gene/?term=7001 "HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020537 70020 Ino80b http://www.ncbi.nlm.nih.gov/gene/?term=70020 "2510009I23Rik, HMG1YL4, Hmga1l4, Papa1, Znhit4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020538 7003 TEAD1 http://www.ncbi.nlm.nih.gov/gene/?term=7003 "AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020539 70044 Tut1 http://www.ncbi.nlm.nih.gov/gene/?term=70044 "2700038E08Rik, PAPD2, Rbm21, TUTase6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020540 7004 TEAD4 http://www.ncbi.nlm.nih.gov/gene/?term=7004 "EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020541 70052 Prpf4 http://www.ncbi.nlm.nih.gov/gene/?term=70052 "1600015H11Rik, AI874830, AW047464, bN189G18.1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020542 70083 Metrn http://www.ncbi.nlm.nih.gov/gene/?term=70083 "1810034B16Rik, Hyrac " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020543 7009 TMBIM6 http://www.ncbi.nlm.nih.gov/gene/?term=7009 "BAXI1, BI-1, TEGT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020544 7009 TMBIM6 http://www.ncbi.nlm.nih.gov/gene/?term=7009 "BAXI1, BI-1, TEGT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020545 70118 Srrd http://www.ncbi.nlm.nih.gov/gene/?term=70118 "2810002G02Rik, Srr1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020546 70120 Yars2 http://www.ncbi.nlm.nih.gov/gene/?term=70120 "2210023C10Rik, tyrRS " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020547 70122 Mllt3 http://www.ncbi.nlm.nih.gov/gene/?term=70122 "2210011H10Rik, 2610012I03Rik, 3830408D16Rik, Af9, D4Ertd321e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020548 70125 2210016H18Rik http://www.ncbi.nlm.nih.gov/gene/?term=70125 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020549 70127 Dpf3 http://www.ncbi.nlm.nih.gov/gene/?term=70127 "2810403B03Rik, 6530402L11Rik, BAF45C, C78788, CERD4, cer-d4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020550 7012 TERC http://www.ncbi.nlm.nih.gov/gene/?term=7012 "DKCA1, PFBMFT2, SCARNA19, TR, TRC3, hTR " lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020551 7012 TERC http://www.ncbi.nlm.nih.gov/gene/?term=7012 "DKCA1, PFBMFT2, SCARNA19, TR, TRC3, hTR " lncRNA Homo sapiens 21963238 Nucleus HeLa cell Chip-seq "TERC binding sites in the genome, which represents a large resource to study potential non-canonical functions of TERC RNA and telomerase (Table S2) " RLID00020552 7012 TERC http://www.ncbi.nlm.nih.gov/gene/?term=7012 "DKCA1, PFBMFT2, SCARNA19, TR, TRC3, hTR " lncRNA Homo sapiens 21381227 Nucleus NIH3T3 cell In situ hybridization Nucleus with abnormal FISH pattern for hTERC was observed in 0.94-90.65% of SCC cells and in 0-85.59% of CIN III cells. RLID00020553 7012 TERC http://www.ncbi.nlm.nih.gov/gene/?term=7012 "DKCA1, PFBMFT2, SCARNA19, TR, TRC3, hTR " lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00020554 7012 TERC http://www.ncbi.nlm.nih.gov/gene/?term=7012 "DKCA1, PFBMFT2, SCARNA19, TR, TRC3, hTR " lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00020555 7012 TERC http://www.ncbi.nlm.nih.gov/gene/?term=7012 "DKCA1, PFBMFT2, SCARNA19, TR, TRC3, hTR " lncRNA Homo sapiens 25630241 Nucleus Hela cell qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00020556 7012 TERC http://www.ncbi.nlm.nih.gov/gene/?term=7012 "DKCA1, PFBMFT2, SCARNA19, TR, TRC3, hTR " lncRNA Homo sapiens 25630241 Nucleus Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00020557 7013 TERF1 http://www.ncbi.nlm.nih.gov/gene/?term=7013 "PIN2, TRBF1, TRF, TRF1, hTRF1-AS, t-TRF1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020558 7013 TERF1 http://www.ncbi.nlm.nih.gov/gene/?term=7013 "PIN2, TRBF1, TRF, TRF1, hTRF1-AS, t-TRF1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020559 7013 TERF1 http://www.ncbi.nlm.nih.gov/gene/?term=7013 "PIN2, TRBF1, TRF, TRF1, hTRF1-AS, t-TRF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020560 70141 2210414I22Rik http://www.ncbi.nlm.nih.gov/gene/?term=70141 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020561 7014 TERF2 http://www.ncbi.nlm.nih.gov/gene/?term=7014 "TRBF2, TRF2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020562 7014 TERF2 http://www.ncbi.nlm.nih.gov/gene/?term=7014 "TRBF2, TRF2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020563 7014 TERF2 http://www.ncbi.nlm.nih.gov/gene/?term=7014 "TRBF2, TRF2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020564 7014 TERF2 http://www.ncbi.nlm.nih.gov/gene/?term=7014 "TRBF2, TRF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020565 7016 TESK1 http://www.ncbi.nlm.nih.gov/gene/?term=7016 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020566 7016 TESK1 http://www.ncbi.nlm.nih.gov/gene/?term=7016 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020567 70186 Fam162a http://www.ncbi.nlm.nih.gov/gene/?term=70186 "2310056P07Rik, HGTD-P " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00020568 70189 2010015P12Rik http://www.ncbi.nlm.nih.gov/gene/?term=70189 AI605416 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020569 7018 TF http://www.ncbi.nlm.nih.gov/gene/?term=7018 "HEL-S-71p, PRO1557, PRO2086, TFQTL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020570 7019 TFAM http://www.ncbi.nlm.nih.gov/gene/?term=7019 "MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020571 7019 TFAM http://www.ncbi.nlm.nih.gov/gene/?term=7019 "MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020572 701 BUB1B http://www.ncbi.nlm.nih.gov/gene/?term=701 "BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020573 701 BUB1B http://www.ncbi.nlm.nih.gov/gene/?term=701 "BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020574 701 BUB1B http://www.ncbi.nlm.nih.gov/gene/?term=701 "BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020575 70205 2310068C19Rik http://www.ncbi.nlm.nih.gov/gene/?term=70205 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020576 70208 Med23 http://www.ncbi.nlm.nih.gov/gene/?term=70208 "130kDa, 3000002A17Rik, Crsp3, ESTM7, Sur2, X83317, mKIAA1216 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020577 70209 Tmem143 http://www.ncbi.nlm.nih.gov/gene/?term=70209 "2310076O21Rik, AI481604 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020578 7020 TFAP2A http://www.ncbi.nlm.nih.gov/gene/?term=7020 "AP-2, AP-2alpha, AP2TF, BOFS, TFAP2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020579 70218 Kif18b http://www.ncbi.nlm.nih.gov/gene/?term=70218 3000004C01Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020580 7021 TFAP2B http://www.ncbi.nlm.nih.gov/gene/?term=7021 "AP-2B, AP2-B " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020581 70223 Nars http://www.ncbi.nlm.nih.gov/gene/?term=70223 "3010001M15Rik, AA960128, ASNRS, C78150 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020582 7022 TFAP2C http://www.ncbi.nlm.nih.gov/gene/?term=7022 "AP2-GAMMA, ERF1, TFAP2G, hAP-2g " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020583 70235 Poc1a http://www.ncbi.nlm.nih.gov/gene/?term=70235 "2510040D07Rik, Wdr51a, cha " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020584 70237 Bhlhb9 http://www.ncbi.nlm.nih.gov/gene/?term=70237 2700087I09Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020585 70238 Rnf168 http://www.ncbi.nlm.nih.gov/gene/?term=70238 3110001H15Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020586 70239 Gtf3c5 http://www.ncbi.nlm.nih.gov/gene/?term=70239 "2700084A09Rik, TFIIIC63, TFiiiC2-63 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020587 7023 TFAP4 http://www.ncbi.nlm.nih.gov/gene/?term=7023 "AP-4, bHLHc41 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020588 7023 TFAP4 http://www.ncbi.nlm.nih.gov/gene/?term=7023 "AP-4, bHLHc41 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020589 70247 Psmd1 http://www.ncbi.nlm.nih.gov/gene/?term=70247 "2410026J11Rik, P112, S1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020590 7024 TFCP2 http://www.ncbi.nlm.nih.gov/gene/?term=7024 "LBP1C, LSF, LSF1D, SEF, TFCP2C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020591 7026 NR2F2 http://www.ncbi.nlm.nih.gov/gene/?term=7026 "ARP1, CHTD4, COUPTFB, COUPTFII, NF-E3, NR2F1, SVP40, TFCOUP2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020592 7026 NR2F2 http://www.ncbi.nlm.nih.gov/gene/?term=7026 "ARP1, CHTD4, COUPTFB, COUPTFII, NF-E3, NR2F1, SVP40, TFCOUP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020593 7027 TFDP1 http://www.ncbi.nlm.nih.gov/gene/?term=7027 "DILC, DP1, DRTF1, Dp-1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020594 7027 TFDP1 http://www.ncbi.nlm.nih.gov/gene/?term=7027 "DILC, DP1, DRTF1, Dp-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020595 70285 Rpf1 http://www.ncbi.nlm.nih.gov/gene/?term=70285 "2210420E24Rik, 2310066N05Rik, Bxdc5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020596 70295 2610011I18Rik http://www.ncbi.nlm.nih.gov/gene/?term=70295 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020597 70296 Tbc1d13 http://www.ncbi.nlm.nih.gov/gene/?term=70296 "2600014A06Rik, BC025586 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020598 70297 Gcc2 http://www.ncbi.nlm.nih.gov/gene/?term=70297 "0610043A03Rik, 2210420P05Rik, 2600014C01Rik, AW112121, mKIAA0336 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020599 70299 2610012C04Rik http://www.ncbi.nlm.nih.gov/gene/?term=70299 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020600 7029 TFDP2 http://www.ncbi.nlm.nih.gov/gene/?term=7029 DP2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020601 7030 TFE3 http://www.ncbi.nlm.nih.gov/gene/?term=7030 "RCCP2, RCCX1, TFEA, bHLHe33 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020602 7031 TFF1 http://www.ncbi.nlm.nih.gov/gene/?term=7031 "BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020603 7031 TFF1 http://www.ncbi.nlm.nih.gov/gene/?term=7031 "BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020604 70335 Reep6 http://www.ncbi.nlm.nih.gov/gene/?term=70335 "0610011M24Rik, Dp1l1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020605 7033 TFF3 http://www.ncbi.nlm.nih.gov/gene/?term=7033 "ITF, P1B, TFI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020606 7033 TFF3 http://www.ncbi.nlm.nih.gov/gene/?term=7033 "ITF, P1B, TFI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020607 70349 Copb1 http://www.ncbi.nlm.nih.gov/gene/?term=70349 2610019B04Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020608 70350 Basp1 http://www.ncbi.nlm.nih.gov/gene/?term=70350 "2610024P12Rik, CAP-23, CAP23, Ckap3, NAP-22, NAP22 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020609 70351 Ppp4r1 http://www.ncbi.nlm.nih.gov/gene/?term=70351 "3110001J10Rik, Pp4r1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020610 70359 Gtpbp3 http://www.ncbi.nlm.nih.gov/gene/?term=70359 "2410009F13Rik, AI607903 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020611 7035 TFPI http://www.ncbi.nlm.nih.gov/gene/?term=7035 "EPI, LACI, TFI1, TFPI " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020612 7035 TFPI http://www.ncbi.nlm.nih.gov/gene/?term=7035 "EPI, LACI, TFI1, TFPI " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020613 7035 TFPI http://www.ncbi.nlm.nih.gov/gene/?term=7035 "EPI, LACI, TFI1, TFPI " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020614 70361 Lman1 http://www.ncbi.nlm.nih.gov/gene/?term=70361 "2610020P13Rik, AI326273, AU043785, C730041J05, ERGIC53, F5F8D, MCFD1, MR60, P58, gp58 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020615 7036 TFR2 http://www.ncbi.nlm.nih.gov/gene/?term=7036 "HFE3, TFRC2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020616 70378 1810073G21Rik http://www.ncbi.nlm.nih.gov/gene/?term=70378 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020617 7037 TFRC http://www.ncbi.nlm.nih.gov/gene/?term=7037 "CD71, IMD46, T9, TFR, TFR1, TR, TRFR, p90 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020618 7037 TFRC http://www.ncbi.nlm.nih.gov/gene/?term=7037 "CD71, IMD46, T9, TFR, TFR1, TR, TRFR, p90 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020619 7037 TFRC http://www.ncbi.nlm.nih.gov/gene/?term=7037 "CD71, IMD46, T9, TFR, TFR1, TR, TRFR, p90 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020620 7037 TFRC http://www.ncbi.nlm.nih.gov/gene/?term=7037 "CD71, IMD46, T9, TFR, TFR1, TR, TRFR, p90 " mRNA Homo sapiens 22679391 Endoplasmic reticulum U2OS cell RT-PCR "Figure 3B: The levels of several transcripts in the ER fraction were analyzed as in (A). Measured transcripts include those encoding ER luminal proteins (BiP, Calreticulin), ER membrane proteins (Inositol-3-phosphate Receptor (IP3 Receptor), Sec61α, Trapα, and Fatty Acid Desaturase 3 (FADS3)), a Golgi protein (Mannosidase 2A (Man2A)), plasma membrane proteins (Integrin β1, and Transferrin Receptor (Tf Receptor)), and a secreted protein (Interleukin 7 (IL7)). All measurements were standardized to the level of mRNA in the ER fraction from control cells. Data are collected from Figure 3B. " RLID00020621 7037 TFRC http://www.ncbi.nlm.nih.gov/gene/?term=7037 "CD71, IMD46, T9, TFR, TFR1, TR, TRFR, p90 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020622 70383 Cox10 http://www.ncbi.nlm.nih.gov/gene/?term=70383 "2410004F01Rik, AU042636 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020623 70385 Spdl1 http://www.ncbi.nlm.nih.gov/gene/?term=70385 "1700018I02Rik, 2600001J17Rik, 2810049B11Rik, AA409762, Ccdc99 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020624 70394 Kptn http://www.ncbi.nlm.nih.gov/gene/?term=70394 "2310042D10Rik, 2E4, C030013F01Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020625 70396 Asnsd1 http://www.ncbi.nlm.nih.gov/gene/?term=70396 2210409M21Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020626 70397 Tmem70 http://www.ncbi.nlm.nih.gov/gene/?term=70397 "1110020A09Rik, 2210416J16Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020627 7039 TGFA http://www.ncbi.nlm.nih.gov/gene/?term=7039 TFGA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020628 7040 TGFB1 http://www.ncbi.nlm.nih.gov/gene/?term=7040 "CED, DPD1, LAP, TGFB, TGFbeta " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020629 70417 Megf10 http://www.ncbi.nlm.nih.gov/gene/?term=70417 "3000002B06Rik, Gm331 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00020630 7041 TGFB1I1 http://www.ncbi.nlm.nih.gov/gene/?term=7041 "ARA55, HIC-5, HIC5, TSC-5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020631 70420 Arpin http://www.ncbi.nlm.nih.gov/gene/?term=70420 2610034B18Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020632 70422 Ints2 http://www.ncbi.nlm.nih.gov/gene/?term=70422 "2810417D08Rik, AA408260, AI987735, mKIAA1287 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020633 70428 Polr3b http://www.ncbi.nlm.nih.gov/gene/?term=70428 "2700078H01Rik, A330032P03Rik, C85372, RPC2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020634 70428 Polr3b http://www.ncbi.nlm.nih.gov/gene/?term=70428 "2700078H01Rik, A330032P03Rik, C85372, RPC2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020635 7042 TGFB2 http://www.ncbi.nlm.nih.gov/gene/?term=7042 "LDS4, TGF-beta2 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00020636 7042 TGFB2 http://www.ncbi.nlm.nih.gov/gene/?term=7042 "LDS4, TGF-beta2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020637 7042 TGFB2 http://www.ncbi.nlm.nih.gov/gene/?term=7042 "LDS4, TGF-beta2 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00020638 70432 Rufy2 http://www.ncbi.nlm.nih.gov/gene/?term=70432 "2610111M19Rik, AI844453, Denn, LZ-FYVE, ZFYVE13 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020639 70439 Taf15 http://www.ncbi.nlm.nih.gov/gene/?term=70439 "2610111C21Rik, 68kDa, TAFII68, Taf2n " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020640 7043 TGFB3 http://www.ncbi.nlm.nih.gov/gene/?term=7043 "ARVD, ARVD1, LDS5, RNHF, TGF-beta3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020641 7044 LEFTY2 http://www.ncbi.nlm.nih.gov/gene/?term=7044 "EBAF, LEFTA, LEFTYA, TGFB4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020642 70454 Cenpl http://www.ncbi.nlm.nih.gov/gene/?term=70454 "2610300B10Rik, AW121806, AW550697, CENP-L " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020643 70454 Cenpl http://www.ncbi.nlm.nih.gov/gene/?term=70454 "2610300B10Rik, AW121806, AW550697, CENP-L " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020644 7045 TGFBI http://www.ncbi.nlm.nih.gov/gene/?term=7045 "BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020645 70466 Ckap2l http://www.ncbi.nlm.nih.gov/gene/?term=70466 "2010016H04Rik, 2610318C08Rik, AV070319, radmis, rdm " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020646 7046 TGFBR1 http://www.ncbi.nlm.nih.gov/gene/?term=7046 "AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020647 7046 TGFBR1 http://www.ncbi.nlm.nih.gov/gene/?term=7046 "AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020648 70472 Atad2 http://www.ncbi.nlm.nih.gov/gene/?term=70472 2610509G12Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020649 70474 5730405A10Rik http://www.ncbi.nlm.nih.gov/gene/?term=70474 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020650 70478 Mipep http://www.ncbi.nlm.nih.gov/gene/?term=70478 "5730405E07Rik, MIP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020651 70488 5730405O12Rik http://www.ncbi.nlm.nih.gov/gene/?term=70488 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020652 70489 5730405O15Rik http://www.ncbi.nlm.nih.gov/gene/?term=70489 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020653 7048 TGFBR2 http://www.ncbi.nlm.nih.gov/gene/?term=7048 "AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020654 70495 Atp6ap2 http://www.ncbi.nlm.nih.gov/gene/?term=70495 "(P)RR, 5730403E06Rik, APT6M8-9, ATP6M8-9, Atp6ip2, M8-9 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020655 7049 TGFBR3 http://www.ncbi.nlm.nih.gov/gene/?term=7049 "BGCAN, betaglycan " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020656 70508 Bbx http://www.ncbi.nlm.nih.gov/gene/?term=70508 "5530401J07Rik, 5730403O13Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020657 70509 5730405N03Rik http://www.ncbi.nlm.nih.gov/gene/?term=70509 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020658 7050 TGIF1 http://www.ncbi.nlm.nih.gov/gene/?term=7050 "HPE4, TGIF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020659 70516 5730408A14Rik http://www.ncbi.nlm.nih.gov/gene/?term=70516 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020660 7052 TGM2 http://www.ncbi.nlm.nih.gov/gene/?term=7052 "G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020661 70551 Tmtc4 http://www.ncbi.nlm.nih.gov/gene/?term=70551 "4930403J22Rik, 5730419O14Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020662 70556 Slc25a33 http://www.ncbi.nlm.nih.gov/gene/?term=70556 "5730438N18Rik, Pnc1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020663 70561 Txndc16 http://www.ncbi.nlm.nih.gov/gene/?term=70561 "5730420B22Rik, C77647 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020664 70572 Ipo5 http://www.ncbi.nlm.nih.gov/gene/?term=70572 "1110011C18Rik, 5730478E03Rik, AA409333, C76941, IMB3, Kpnb3, Ranbp5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020665 70574 Cpm http://www.ncbi.nlm.nih.gov/gene/?term=70574 "1110060I01Rik, 5730456K23Rik, AA589379, E030045M14Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020666 70575 Gfod2 http://www.ncbi.nlm.nih.gov/gene/?term=70575 5730466C23Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020667 70579 Zc3h11a http://www.ncbi.nlm.nih.gov/gene/?term=70579 "1110003F06Rik, 5730454B08Rik, G630041M05Rik, Zc3hdc11a, Zc3hh11a, mKIAA0663 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020668 70579 Zc3h11a http://www.ncbi.nlm.nih.gov/gene/?term=70579 "1110003F06Rik, 5730454B08Rik, G630041M05Rik, Zc3hdc11a, Zc3hh11a, mKIAA0663 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020669 70584 Pak4 http://www.ncbi.nlm.nih.gov/gene/?term=70584 "5730488L07Rik, AW555722, mKIAA1142 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020670 70599 Ssfa2 http://www.ncbi.nlm.nih.gov/gene/?term=70599 "5730488C15Rik, CS-1, CS1, KRAP, SPAG13, mKIAA1927 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020671 7059 THBS3 http://www.ncbi.nlm.nih.gov/gene/?term=7059 TSP3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020672 705 BYSL http://www.ncbi.nlm.nih.gov/gene/?term=705 BYSTIN mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020673 705 BYSL http://www.ncbi.nlm.nih.gov/gene/?term=705 BYSTIN mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020674 705 BYSL http://www.ncbi.nlm.nih.gov/gene/?term=705 BYSTIN mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020675 70619 5730510P18Rik http://www.ncbi.nlm.nih.gov/gene/?term=70619 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020676 70625 Med26 http://www.ncbi.nlm.nih.gov/gene/?term=70625 "5730493L18Rik, AI414941, AW495270, Crsp7 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020677 7064 THOP1 http://www.ncbi.nlm.nih.gov/gene/?term=7064 "EP24.15, MEPD_HUMAN, MP78, TOP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020678 70650 Zcchc8 http://www.ncbi.nlm.nih.gov/gene/?term=70650 5730565F05Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020679 7066 THPO http://www.ncbi.nlm.nih.gov/gene/?term=7066 "MGDF, MKCSF, ML, MPLLG, THCYT1, TPO " mRNA Homo sapiens 25063809 Ribosome HeLa cell qRT-PCR Figure 1: Endoplasmic reticulum-associated mRNAs are partitioned between detergent-resistant and detergent-sensitive membrane domains. Data are collected from Figure 1. RLID00020680 70673 Prdm16 http://www.ncbi.nlm.nih.gov/gene/?term=70673 "5730557K01Rik, csp1, mel1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020681 70675 Vcpip1 http://www.ncbi.nlm.nih.gov/gene/?term=70675 "4932442A08, 5730421J18Rik, 5730538E15Rik, VCIP135, mKIAA1850 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020682 70675 Vcpip1 http://www.ncbi.nlm.nih.gov/gene/?term=70675 "4932442A08, 5730421J18Rik, 5730538E15Rik, VCIP135, mKIAA1850 " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00020683 70676 Gulp1 http://www.ncbi.nlm.nih.gov/gene/?term=70676 "3110030A04Rik, 5730529O06Rik, CED-6, Ced6, GULP, Gulp-2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020684 7067 THRA http://www.ncbi.nlm.nih.gov/gene/?term=7067 "AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A11, THRA2, c-ERBA-1, THRA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020685 7067 THRA http://www.ncbi.nlm.nih.gov/gene/?term=7067 "AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020686 70683 Utp20 http://www.ncbi.nlm.nih.gov/gene/?term=70683 "3830408P06Rik, AA617408, Drim, mDRIM, mDRIN " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020687 70693 Adgra3 http://www.ncbi.nlm.nih.gov/gene/?term=70693 "3830613O22Rik, AU044632, Gpr125, Tem5-like " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020688 70699 Nup205 http://www.ncbi.nlm.nih.gov/gene/?term=70699 "3830404O05Rik, AV248391, mKIAA0225 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020689 706 TSPO http://www.ncbi.nlm.nih.gov/gene/?term=706 "BPBS, BZRP, DBI, IBP, MBR, PBR, PBS, PKBS, PTBR, mDRC, pk18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020690 7070 THY1 http://www.ncbi.nlm.nih.gov/gene/?term=7070 "CD90, CDw90 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020691 7071 KLF10 http://www.ncbi.nlm.nih.gov/gene/?term=7071 "EGR-alpha, EGRA, TIEG, TIEG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020692 7072 TIA1 http://www.ncbi.nlm.nih.gov/gene/?term=7072 "TIA-1, WDM " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020693 7072 TIA1 http://www.ncbi.nlm.nih.gov/gene/?term=7072 "TIA-1, WDM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020694 7073 TIAL1 http://www.ncbi.nlm.nih.gov/gene/?term=7073 "TCBP, TIAR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020695 7073 TIAL1 http://www.ncbi.nlm.nih.gov/gene/?term=7073 "TCBP, TIAR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020696 70747 Tspan2 http://www.ncbi.nlm.nih.gov/gene/?term=70747 "6330415F13Rik, B230119D02Rik, tspan-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020697 70757 Hacd2 http://www.ncbi.nlm.nih.gov/gene/?term=70757 "6330408J20Rik, AI255777, AI481689, Hcad2, Ptplb " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020698 7075 TIE1 http://www.ncbi.nlm.nih.gov/gene/?term=7075 "JTK14, TIE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020699 70760 6330417A16Rik http://www.ncbi.nlm.nih.gov/gene/?term=70760 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020700 7076 TIMP1 http://www.ncbi.nlm.nih.gov/gene/?term=7076 "CLGI, EPA, EPO, HCI, TIMP, TIMP-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020701 7076 TIMP1 http://www.ncbi.nlm.nih.gov/gene/?term=7076 "CLGI, EPA, EPO, HCI, TIMP, TIMP-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020702 7076 TIMP1 http://www.ncbi.nlm.nih.gov/gene/?term=7076 "CLGI, EPA, EPO, HCI, TIMP, TIMP-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020703 7077 TIMP2 http://www.ncbi.nlm.nih.gov/gene/?term=7077 "CSC-21K, DDC8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020704 7077 TIMP2 http://www.ncbi.nlm.nih.gov/gene/?term=7077 "CSC-21K, DDC8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020705 7077 TIMP2 http://www.ncbi.nlm.nih.gov/gene/?term=7077 "CSC-21K, DDC8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020706 70788 Klhl30 http://www.ncbi.nlm.nih.gov/gene/?term=70788 4631423F02Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020707 7078 TIMP3 http://www.ncbi.nlm.nih.gov/gene/?term=7078 "HSMRK222, K222, K222TA2, SFD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020708 7078 TIMP3 http://www.ncbi.nlm.nih.gov/gene/?term=7078 "HSMRK222, K222, K222TA2, SFD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020709 70790 Ubr5 http://www.ncbi.nlm.nih.gov/gene/?term=70790 "Edd, Edd1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020710 70791 Hars2 http://www.ncbi.nlm.nih.gov/gene/?term=70791 "4631412B19Rik, HARSR, HO3, Harsl " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020711 70796 Zdhhc1 http://www.ncbi.nlm.nih.gov/gene/?term=70796 4432412D04Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020712 70799 Cep192 http://www.ncbi.nlm.nih.gov/gene/?term=70799 "4631422C13Rik, D430014P18Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020713 7079 TIMP4 http://www.ncbi.nlm.nih.gov/gene/?term=7079 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020714 70804 Pgrmc2 http://www.ncbi.nlm.nih.gov/gene/?term=70804 "4631434O19Rik, 5730409G06Rik, DG6, PMBP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020715 70808 4632415L05Rik http://www.ncbi.nlm.nih.gov/gene/?term=70808 AI662792 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020716 70809 Clec2g http://www.ncbi.nlm.nih.gov/gene/?term=70809 "4632413B12Rik, Clr-c, Clr-d, Clrc, Clrd, Clrx, Ddv10, Ocilrp1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020717 7080 NKX2-1 http://www.ncbi.nlm.nih.gov/gene/?term=7080 "BCH, BHC, NK-2, NKX2.1, NKX2A, NMTC1, T/EBP, TEBP, TITF1, TTF-1, TTF1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020718 70810 Krt25 http://www.ncbi.nlm.nih.gov/gene/?term=70810 "4631426H08Rik, Ka38a, mIRSa1, Krt25 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020719 70821 4921507P07Rik http://www.ncbi.nlm.nih.gov/gene/?term=70821 TISP74 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020720 70825 4633401L03Rik http://www.ncbi.nlm.nih.gov/gene/?term=70825 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020721 70831 Krtap31-1 http://www.ncbi.nlm.nih.gov/gene/?term=70831 "4733401H21Rik, AI506529 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020722 70834 Spag9 http://www.ncbi.nlm.nih.gov/gene/?term=70834 "3110018C07Rik, 4733401I23Rik, 4831406C20Rik, AW552012, JLP, JSAP2, JSAP2a, Jip4, Mapk8ip4, syd1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020723 7083 TK1 http://www.ncbi.nlm.nih.gov/gene/?term=7083 TK2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020724 7083 TK1 http://www.ncbi.nlm.nih.gov/gene/?term=7083 TK2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020725 7083 TK1 http://www.ncbi.nlm.nih.gov/gene/?term=7083 TK2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020726 7084 TK2 http://www.ncbi.nlm.nih.gov/gene/?term=7084 "MTDPS2, MTTK, SCA31 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020727 7084 TK2 http://www.ncbi.nlm.nih.gov/gene/?term=7084 "MTDPS2, MTTK, SCA31 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020728 70853 Vwa3b http://www.ncbi.nlm.nih.gov/gene/?term=70853 "4921511C04Rik, A230074B11Rik, Gm555 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020729 70859 Lrrc63 http://www.ncbi.nlm.nih.gov/gene/?term=70859 4921509B22Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020730 70861 Akr1cl http://www.ncbi.nlm.nih.gov/gene/?term=70861 "4921521F21Rik, AI451536, AI503553 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020731 7086 TKT http://www.ncbi.nlm.nih.gov/gene/?term=7086 "HEL-S-48, HEL107, TK1, TKT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020732 7087 ICAM5 http://www.ncbi.nlm.nih.gov/gene/?term=7087 "TLCN, TLN " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020733 70881 Nt5c1b http://www.ncbi.nlm.nih.gov/gene/?term=70881 "4921514H13Rik, AIRP, CN-IB, cN1B " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020734 70885 Ints10 http://www.ncbi.nlm.nih.gov/gene/?term=70885 "4921521J11Rik, AI462004 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020735 70888 4921521C08Rik http://www.ncbi.nlm.nih.gov/gene/?term=70888 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020736 7088 TLE1 http://www.ncbi.nlm.nih.gov/gene/?term=7088 "ESG, ESG1, GRG1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020737 70891 Spdya http://www.ncbi.nlm.nih.gov/gene/?term=70891 "4921517J08Rik, 4930548B21Rik, GS4, MLZ-465, Spdy1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020738 70895 4921511E07Rik http://www.ncbi.nlm.nih.gov/gene/?term=70895 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020739 7089 TLE2 http://www.ncbi.nlm.nih.gov/gene/?term=7089 "ESG, ESG2, GRG2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020740 7089 TLE2 http://www.ncbi.nlm.nih.gov/gene/?term=7089 "ESG, ESG2, GRG2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020741 708 C1QBP http://www.ncbi.nlm.nih.gov/gene/?term=708 "GC1QBP, HABP1, SF2p32, gC1Q-R, gC1qR, p32 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020742 7090 TLE3 http://www.ncbi.nlm.nih.gov/gene/?term=7090 "ESG, ESG3, GRG3, HsT18976 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020743 7091 TLE4 http://www.ncbi.nlm.nih.gov/gene/?term=7091 "BCE-1, BCE1, E(spI), ESG, ESG4, GRG4, Grg-4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020744 70941 4921539E11Rik http://www.ncbi.nlm.nih.gov/gene/?term=70941 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020745 7094 TLN1 http://www.ncbi.nlm.nih.gov/gene/?term=7094 "ILWEQ, TLN " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020746 70957 Stamos http://www.ncbi.nlm.nih.gov/gene/?term=70957 4921530L18Rik lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020747 7095 SEC62 http://www.ncbi.nlm.nih.gov/gene/?term=7095 "Dtrp1, HTP1, TLOC1, TP-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020748 7095 SEC62 http://www.ncbi.nlm.nih.gov/gene/?term=7095 "Dtrp1, HTP1, TLOC1, TP-1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020749 7095 SEC62 http://www.ncbi.nlm.nih.gov/gene/?term=7095 "Dtrp1, HTP1, TLOC1, TP-1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020750 7095 SEC62 http://www.ncbi.nlm.nih.gov/gene/?term=7095 "Dtrp1, HTP1, TLOC1, TP-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020751 70974 Pgm2l1 http://www.ncbi.nlm.nih.gov/gene/?term=70974 "4931406N15Rik, AI553438, BM32A " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020752 70997 Spef1 http://www.ncbi.nlm.nih.gov/gene/?term=70997 "4931426K16Rik, Clamp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020753 70998 Phf6 http://www.ncbi.nlm.nih.gov/gene/?term=70998 "2700007B13Rik, 4931428F02Rik, mKIAA1823 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020754 70999 Naa40 http://www.ncbi.nlm.nih.gov/gene/?term=70999 "4931433E08Rik, AU023197, Nat11 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020755 70 ACTC1 http://www.ncbi.nlm.nih.gov/gene/?term=70 "ACTC, ASD5, CMD1R, CMH11, LVNC4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020756 70 ACTC1 http://www.ncbi.nlm.nih.gov/gene/?term=70 "ACTC, ASD5, CMD1R, CMH11, LVNC4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020757 70 ACTC1 http://www.ncbi.nlm.nih.gov/gene/?term=70 "ACTC, ASD5, CMD1R, CMH11, LVNC4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020758 7100 TLR5 http://www.ncbi.nlm.nih.gov/gene/?term=7100 "MELIOS, SLE1, SLEB1, TIL3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020759 71018 4933404K13Rik http://www.ncbi.nlm.nih.gov/gene/?term=71018 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020760 71025 4933402C05Rik http://www.ncbi.nlm.nih.gov/gene/?term=71025 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020761 71029 4933402C06Rik http://www.ncbi.nlm.nih.gov/gene/?term=71029 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020762 7102 TSPAN7 http://www.ncbi.nlm.nih.gov/gene/?term=7102 "A15, CCG-B7, CD231, DXS1692E, MRX58, MXS1, TALLA-1, TM4SF2, TM4SF2b " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020763 71030 4933403O08Rik http://www.ncbi.nlm.nih.gov/gene/?term=71030 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020764 7103 TSPAN8 http://www.ncbi.nlm.nih.gov/gene/?term=7103 "CO-029, TM4SF3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020765 7103 TSPAN8 http://www.ncbi.nlm.nih.gov/gene/?term=7103 "CO-029, TM4SF3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020766 71041 Pcgf6 http://www.ncbi.nlm.nih.gov/gene/?term=71041 "4933407A11Rik, AI604840, MBLR, Rnf134 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020767 71057 4933402J10Rik http://www.ncbi.nlm.nih.gov/gene/?term=71057 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020768 7105 TSPAN6 http://www.ncbi.nlm.nih.gov/gene/?term=7105 "T245, TM4SF6, TSPAN-6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020769 71063 Zfp597 http://www.ncbi.nlm.nih.gov/gene/?term=71063 "4933407K12Rik, AI462383, AI666357 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020770 71067 4933411E08Rik http://www.ncbi.nlm.nih.gov/gene/?term=71067 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020771 71069 Stox2 http://www.ncbi.nlm.nih.gov/gene/?term=71069 "4933409N07Rik, AI449080, AI835114, mKIAA1392 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020772 7106 TSPAN4 http://www.ncbi.nlm.nih.gov/gene/?term=7106 "NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020773 7106 TSPAN4 http://www.ncbi.nlm.nih.gov/gene/?term=7106 "NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020774 71076 4933422E07Rik http://www.ncbi.nlm.nih.gov/gene/?term=71076 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020775 7107 GPR137B http://www.ncbi.nlm.nih.gov/gene/?term=7107 TM7SF1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020776 7107 GPR137B http://www.ncbi.nlm.nih.gov/gene/?term=7107 TM7SF1 mRNA Homo sapiens 19175411 Ribosome T-cell|SeAx qRT-PCR "Using quantitative real-time RT-PCR we evaluated, whether mRNAs coding for differently located proteins are selectively enriched in one of the two analysed compartments, namely free versus membrane-associated polysomes. We selected genes coding for proteins located in the plasma membrane (GPR137B), secreted proteins (TIC2, IBP2, PAI) and cytosolic proteins (the house keeping genes GAPDH and HMBS). In fact, the distribution of the specific mRNA was as predicted ( Fig. 1): The average ratio of specific mRNA at bound ribosomes versus free ribosomes was 1 ? 4.4 for the housekeeping genes (GAPDH and HMBS) and 13.3 ? 1 for genes coding for membrane-bound or secreted proteins. Ratios for genes coding for cytosolic proteins were always below 0.6 and those for membrane or secreted genes were always above 1. The highest values were observed for PAI in MyLa (57 ? 1) and GPR137B in SeAx (34 ? 1), while the lowest ratios were detected for HMBS (1 ? 55) and GAPDH (1 ? 12) in HuT78. " RLID00020777 7107 GPR137B http://www.ncbi.nlm.nih.gov/gene/?term=7107 TM7SF1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020778 7107 GPR137B http://www.ncbi.nlm.nih.gov/gene/?term=7107 TM7SF1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020779 7108 TM7SF2 http://www.ncbi.nlm.nih.gov/gene/?term=7108 "ANG1, DHCR14A, NET47 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020780 71093 Atoh8 http://www.ncbi.nlm.nih.gov/gene/?term=71093 "4933425C05Rik, Hath6, Math6, bHLHa21, okadin " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020781 7109 TRAPPC10 http://www.ncbi.nlm.nih.gov/gene/?term=7109 "EHOC-1, EHOC1, GT334, TMEM1, TRS130, TRS30 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020782 710 SERPING1 http://www.ncbi.nlm.nih.gov/gene/?term=710 "C1IN, C1INH, C1NH, HAE1, HAE2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020783 71101 Uvssa http://www.ncbi.nlm.nih.gov/gene/?term=71101 "4933407H18Rik, D330017J19Rik, Kiaa1530, mKIAA1530 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020784 7110 TMF1 http://www.ncbi.nlm.nih.gov/gene/?term=7110 "ARA160, TMF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020785 7111 TMOD1 http://www.ncbi.nlm.nih.gov/gene/?term=7111 "D9S57E, ETMOD, TMOD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020786 7111 TMOD1 http://www.ncbi.nlm.nih.gov/gene/?term=7111 "D9S57E, ETMOD, TMOD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020787 7112 TMPO http://www.ncbi.nlm.nih.gov/gene/?term=7112 "CMD1T, LAP2, LEMD4, PRO0868, TP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020788 7112 TMPO http://www.ncbi.nlm.nih.gov/gene/?term=7112 "CMD1T, LAP2, LEMD4, PRO0868, TP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020789 71135 4933411O13Rik http://www.ncbi.nlm.nih.gov/gene/?term=71135 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020790 71137 Rfx4 http://www.ncbi.nlm.nih.gov/gene/?term=71137 "4933412G19Rik, NYD-sp10 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020791 7113 TMPRSS2 http://www.ncbi.nlm.nih.gov/gene/?term=7113 "PP9284, PRSS10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020792 71145 Scara5 http://www.ncbi.nlm.nih.gov/gene/?term=71145 "4932433F15Rik, 4933425F03Rik, AV278087, Tesr " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020793 71148 Mier1 http://www.ncbi.nlm.nih.gov/gene/?term=71148 "4933425I22Rik, 5830411K19Rik, er1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020794 7114 TMSB4X http://www.ncbi.nlm.nih.gov/gene/?term=7114 "FX, PTMB4, TB4X, TMSB4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020795 7114 TMSB4X http://www.ncbi.nlm.nih.gov/gene/?term=7114 "FX, PTMB4, TB4X, TMSB4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020796 7114 TMSB4X http://www.ncbi.nlm.nih.gov/gene/?term=7114 "FX, PTMB4, TB4X, TMSB4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020797 71151 Eri2 http://www.ncbi.nlm.nih.gov/gene/?term=71151 "4933424N09Rik, Exod1, mKIAA1504 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020798 71175 Nipbl http://www.ncbi.nlm.nih.gov/gene/?term=71175 Idn3 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020799 71177 Asun http://www.ncbi.nlm.nih.gov/gene/?term=71177 "4933424B01Rik, Spata30 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020800 71181 4933411E06Rik http://www.ncbi.nlm.nih.gov/gene/?term=71181 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020801 71190 4933425M03Rik http://www.ncbi.nlm.nih.gov/gene/?term=71190 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020802 71213 Cage1 http://www.ncbi.nlm.nih.gov/gene/?term=71213 "4933427I01Rik, Ctag3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020803 71223 Gpr15 http://www.ncbi.nlm.nih.gov/gene/?term=71223 4933439K08Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020804 71237 4933435G04Rik http://www.ncbi.nlm.nih.gov/gene/?term=71237 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020805 7123 CLEC3B http://www.ncbi.nlm.nih.gov/gene/?term=7123 "TN, TNA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020806 7124 TNF http://www.ncbi.nlm.nih.gov/gene/?term=7124 "DIF-alpha, TNFA, TNFSF2, TNLG1F, TNF " mRNA Homo sapiens 26000482 Ribosome HeLa cell qRT-PCR "Because Il6, Tnf, and Ptgs2 mRNAs present in polysomal fractions rapidly increased in response to IL-1 b stimulation in HeLa cells and then decreased at later time points ( Figures 3 H and S7 C), we hypothesized that the contribu- tion of translation-dependent decay by Reg1 changes in the time course of BMM activation. " RLID00020807 71268 Lrrfip2 http://www.ncbi.nlm.nih.gov/gene/?term=71268 "5133400F20Rik, AI850587 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020808 7126 TNFAIP1 http://www.ncbi.nlm.nih.gov/gene/?term=7126 "B12, B61, BTBD34, EDP1, hBACURD2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020809 71270 4933438K21Rik http://www.ncbi.nlm.nih.gov/gene/?term=71270 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020810 71279 Slc29a3 http://www.ncbi.nlm.nih.gov/gene/?term=71279 "4933435C21Rik, AW987637, Ent3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020811 7127 TNFAIP2 http://www.ncbi.nlm.nih.gov/gene/?term=7127 "B94, EXOC3L3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020812 7127 TNFAIP2 http://www.ncbi.nlm.nih.gov/gene/?term=7127 "B94, EXOC3L3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020813 71288 4933440K10Rik http://www.ncbi.nlm.nih.gov/gene/?term=71288 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020814 7128 TNFAIP3 http://www.ncbi.nlm.nih.gov/gene/?term=7128 "A20, AISBL, OTUD7C, TNFA1P2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020815 71299 4933439N06Rik http://www.ncbi.nlm.nih.gov/gene/?term=71299 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020816 71301 4930593A02Rik http://www.ncbi.nlm.nih.gov/gene/?term=71301 4933440I01Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020817 7132 TNFRSF1A http://www.ncbi.nlm.nih.gov/gene/?term=7132 "CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020818 7132 TNFRSF1A http://www.ncbi.nlm.nih.gov/gene/?term=7132 "CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020819 7133 TNFRSF1B http://www.ncbi.nlm.nih.gov/gene/?term=7133 "CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020820 7133 TNFRSF1B http://www.ncbi.nlm.nih.gov/gene/?term=7133 "CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020821 71340 Riok1 http://www.ncbi.nlm.nih.gov/gene/?term=71340 "3110046C13Rik, 5430416A05Rik, Ad034 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020822 7135 TNNI1 http://www.ncbi.nlm.nih.gov/gene/?term=7135 "SSTNI, TNN1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020823 7135 TNNI1 http://www.ncbi.nlm.nih.gov/gene/?term=7135 "SSTNI, TNN1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020824 7135 TNNI1 http://www.ncbi.nlm.nih.gov/gene/?term=7135 "SSTNI, TNN1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020825 71360 5530401D11Rik http://www.ncbi.nlm.nih.gov/gene/?term=71360 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020826 71361 Aifm2 http://www.ncbi.nlm.nih.gov/gene/?term=71361 "5430437E11Rik, Amid, D730001I10Rik, PRG3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020827 71367 Chst9 http://www.ncbi.nlm.nih.gov/gene/?term=71367 5430438D01Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020828 71371 Arid5b http://www.ncbi.nlm.nih.gov/gene/?term=71371 "4930580B11, 5430435G07Rik, AI467247, Desrt, Mrf2, Mrf2alpha, Mrf2beta " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020829 71382 Pex1 http://www.ncbi.nlm.nih.gov/gene/?term=71382 "5430414H02Rik, E330005K07Rik, ZWS1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020830 71389 Chd6 http://www.ncbi.nlm.nih.gov/gene/?term=71389 "5430439G14Rik, 6330406J24Rik, CHD-6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020831 71393 Kctd6 http://www.ncbi.nlm.nih.gov/gene/?term=71393 "5430433B02Rik, AU044285 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020832 71409 Fmnl2 http://www.ncbi.nlm.nih.gov/gene/?term=71409 "5430425K04Rik, Man " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020833 71420 5530400N10Rik http://www.ncbi.nlm.nih.gov/gene/?term=71420 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020834 71445 5530601H04Rik http://www.ncbi.nlm.nih.gov/gene/?term=71445 AI835882 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020835 71452 Ankrd40 http://www.ncbi.nlm.nih.gov/gene/?term=71452 "1110011C06Rik, 5530600A18Rik, Gcap15 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020836 71456 8430401P03Rik http://www.ncbi.nlm.nih.gov/gene/?term=71456 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020837 71458 Bcor http://www.ncbi.nlm.nih.gov/gene/?term=71458 "2900008C10Rik, 5830466J11Rik, 8430401K06RikR, D930024N20Rik, mKIAA1575, Bcor " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020838 7148 TNXB http://www.ncbi.nlm.nih.gov/gene/?term=7148 "EDS3, HXBL, TENX, TN-X, TNX, TNXB1, TNXB2, TNXBS, VUR8, XB, XBS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020839 714 C1QC http://www.ncbi.nlm.nih.gov/gene/?term=714 "C1Q-C, C1QG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020840 71514 Sfpq http://www.ncbi.nlm.nih.gov/gene/?term=71514 "1110004P21Rik, 2810416M14Rik, 5730453G22Rik, 9030402K04Rik, AU021830, D4Ertd314e, Gm12940, OTTMUSG00000009329, PSF, REP1 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020841 71514 Sfpq http://www.ncbi.nlm.nih.gov/gene/?term=71514 "1110004P21Rik, 2810416M14Rik, 5730453G22Rik, 9030402K04Rik, AU021830, D4Ertd314e, Gm12940, OTTMUSG00000009329, PSF, REP1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020842 71514 Sfpq http://www.ncbi.nlm.nih.gov/gene/?term=71514 "1110004P21Rik, 2810416M14Rik, 5730453G22Rik, 9030402K04Rik, AU021830, D4Ertd314e, Gm12940, OTTMUSG00000009329, PSF, REP1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020843 71521 Pds5a http://www.ncbi.nlm.nih.gov/gene/?term=71521 "9030416H16Rik, E230024D05Rik, mKIAA0648 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020844 71523 8430429K09Rik http://www.ncbi.nlm.nih.gov/gene/?term=71523 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020845 71524 8430432A02Rik http://www.ncbi.nlm.nih.gov/gene/?term=71524 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020846 71534 9030408N04Rik http://www.ncbi.nlm.nih.gov/gene/?term=71534 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020847 7153 TOP2A http://www.ncbi.nlm.nih.gov/gene/?term=7153 "TOP2, TP2A " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020848 7153 TOP2A http://www.ncbi.nlm.nih.gov/gene/?term=7153 "TOP2, TP2A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020849 7155 TOP2B http://www.ncbi.nlm.nih.gov/gene/?term=7155 "TOPIIB, top2beta " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020850 71565 9030418E23Rik http://www.ncbi.nlm.nih.gov/gene/?term=71565 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020851 7156 TOP3A http://www.ncbi.nlm.nih.gov/gene/?term=7156 "TOP3, ZGRF7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020852 7156 TOP3A http://www.ncbi.nlm.nih.gov/gene/?term=7156 "TOP3, ZGRF7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020853 7157 TP53 http://www.ncbi.nlm.nih.gov/gene/?term=7157 "BCC7, LFS1, P53, TRP53 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020854 7157 TP53 http://www.ncbi.nlm.nih.gov/gene/?term=7157 "BCC7, LFS1, P53, TRP53 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020855 71581 9130015A21Rik http://www.ncbi.nlm.nih.gov/gene/?term=71581 "100043575, Gm4527 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020856 71599 Senp8 http://www.ncbi.nlm.nih.gov/gene/?term=71599 "9130010J17Rik, AU020827, Den1, Nedp1, Prsc2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020857 7159 TP53BP2 http://www.ncbi.nlm.nih.gov/gene/?term=7159 "53BP2, ASPP2, BBP, P53BP2, PPP1R13A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020858 7159 TP53BP2 http://www.ncbi.nlm.nih.gov/gene/?term=7159 "53BP2, ASPP2, BBP, P53BP2, PPP1R13A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020859 71611 9130022K11Rik http://www.ncbi.nlm.nih.gov/gene/?term=71611 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020860 7162 TPBG http://www.ncbi.nlm.nih.gov/gene/?term=7162 "5T4, 5T4AG, M6P1, WAIF1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020861 7162 TPBG http://www.ncbi.nlm.nih.gov/gene/?term=7162 "5T4, 5T4AG, M6P1, WAIF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020862 7163 TPD52 http://www.ncbi.nlm.nih.gov/gene/?term=7163 "D52, N8L, PC-1, PrLZ, hD52 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020863 71643 Zgrf1 http://www.ncbi.nlm.nih.gov/gene/?term=71643 "4930422G04Rik, AI448607 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020864 7164 TPD52L1 http://www.ncbi.nlm.nih.gov/gene/?term=7164 D53 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020865 71653 Shtn1 http://www.ncbi.nlm.nih.gov/gene/?term=71653 "4930506M07Rik, Kiaa1598, Shootin1, mKIAA1598 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020866 7165 TPD52L2 http://www.ncbi.nlm.nih.gov/gene/?term=7165 "D54, TPD54 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020867 7165 TPD52L2 http://www.ncbi.nlm.nih.gov/gene/?term=7165 "D54, TPD54 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020868 7165 TPD52L2 http://www.ncbi.nlm.nih.gov/gene/?term=7165 "D54, TPD54 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020869 71660 Rarres2 http://www.ncbi.nlm.nih.gov/gene/?term=71660 "0610007L05Rik, AI303516 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020870 71670 Acy3 http://www.ncbi.nlm.nih.gov/gene/?term=71670 "0610006H10Rik, AA3, AAIII, AW107362, Acy-3, HCBP1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020871 71676 0610012D04Rik http://www.ncbi.nlm.nih.gov/gene/?term=71676 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020872 7167 TPI1 http://www.ncbi.nlm.nih.gov/gene/?term=7167 "HEL-S-49, TIM, TPI, TPID " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020873 7167 TPI1 http://www.ncbi.nlm.nih.gov/gene/?term=7167 "HEL-S-49, TIM, TPI, TPID " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020874 7168 TPM1 http://www.ncbi.nlm.nih.gov/gene/?term=7168 "C15orf13, CMD1Y, CMH3, HEL-S-265, HTM-alpha, LVNC9, TMSA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020875 7168 TPM1 http://www.ncbi.nlm.nih.gov/gene/?term=7168 "C15orf13, CMD1Y, CMH3, HEL-S-265, HTM-alpha, LVNC9, TMSA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020876 7168 TPM1 http://www.ncbi.nlm.nih.gov/gene/?term=7168 "C15orf13, CMD1Y, CMH3, HEL-S-265, HTM-alpha, LVNC9, TMSA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020877 7169 TPM2 http://www.ncbi.nlm.nih.gov/gene/?term=7169 "AMCD1, DA1, DA2B, HEL-S-273, NEM4, TMSB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020878 716 C1S http://www.ncbi.nlm.nih.gov/gene/?term=716 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020879 716 C1S http://www.ncbi.nlm.nih.gov/gene/?term=716 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020880 71701 Pnpt1 http://www.ncbi.nlm.nih.gov/gene/?term=71701 "1200003F12Rik, Old35, PNPase, Pnptl1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020881 71702 Cdc5l http://www.ncbi.nlm.nih.gov/gene/?term=71702 "1200002I02Rik, AA408004, PCDC5RP " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020882 71706 Slc46a3 http://www.ncbi.nlm.nih.gov/gene/?term=71706 1200006F02Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020883 7170 TPM3 http://www.ncbi.nlm.nih.gov/gene/?term=7170 "CAPM1, CFTD, HEL-189, HEL-S-82p, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TM5, TPMsk3, TRK, hscp30 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020884 7170 TPM3 http://www.ncbi.nlm.nih.gov/gene/?term=7170 "CAPM1, CFTD, HEL-189, HEL-S-82p, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TM5, TPMsk3, TRK, hscp30 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020885 7170 TPM3 http://www.ncbi.nlm.nih.gov/gene/?term=7170 "CAPM1, CFTD, HEL-189, HEL-S-82p, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TM5, TPMsk3, TRK, hscp30 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020886 71710 Lrrcc1 http://www.ncbi.nlm.nih.gov/gene/?term=71710 "1200008A14Rik, 4932441F23Rik, AI195358, AI447421 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020887 71711 Mus81 http://www.ncbi.nlm.nih.gov/gene/?term=71711 "1200008A18Rik, AI182501, AW045863 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020888 71713 Cdc40 http://www.ncbi.nlm.nih.gov/gene/?term=71713 "1200003H23Rik, EHB3, PRP17 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020889 71718 Telo2 http://www.ncbi.nlm.nih.gov/gene/?term=71718 "1200003M09Rik, AI415602, Tel2, mKIAA0683 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020890 7171 TPM4 http://www.ncbi.nlm.nih.gov/gene/?term=7171 HEL-S-108 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020891 7171 TPM4 http://www.ncbi.nlm.nih.gov/gene/?term=7171 HEL-S-108 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020892 7171 TPM4 http://www.ncbi.nlm.nih.gov/gene/?term=7171 HEL-S-108 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020893 71726 Smug1 http://www.ncbi.nlm.nih.gov/gene/?term=71726 "1200013B09Rik, A930006H09Rik, C85220 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020894 71728 Stk11ip http://www.ncbi.nlm.nih.gov/gene/?term=71728 "1200014D22Rik, BB131189, LIP1, LKB1IP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020895 71729 Rgs12 http://www.ncbi.nlm.nih.gov/gene/?term=71729 "1200016K18Rik, 4632412M04Rik, AI481290, E130309H11 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020896 7172 TPMT http://www.ncbi.nlm.nih.gov/gene/?term=7172 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020897 7172 TPMT http://www.ncbi.nlm.nih.gov/gene/?term=7172 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020898 7172 TPMT http://www.ncbi.nlm.nih.gov/gene/?term=7172 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020899 7172 TPMT http://www.ncbi.nlm.nih.gov/gene/?term=7172 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020900 7172 TPMT http://www.ncbi.nlm.nih.gov/gene/?term=7172 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020901 71745 Cul2 http://www.ncbi.nlm.nih.gov/gene/?term=71745 "1300003D18Rik, 4932411N15Rik, AI327301, mKIAA4106 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020902 7174 TPP2 http://www.ncbi.nlm.nih.gov/gene/?term=7174 "TPP-2, TPPII " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020903 7174 TPP2 http://www.ncbi.nlm.nih.gov/gene/?term=7174 "TPP-2, TPPII " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020904 7174 TPP2 http://www.ncbi.nlm.nih.gov/gene/?term=7174 "TPP-2, TPPII " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020905 71753 Tmprss6 http://www.ncbi.nlm.nih.gov/gene/?term=71753 1300008A22Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020906 7175 TPR http://www.ncbi.nlm.nih.gov/gene/?term=7175 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020907 7175 TPR http://www.ncbi.nlm.nih.gov/gene/?term=7175 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020908 7175 TPR http://www.ncbi.nlm.nih.gov/gene/?term=7175 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020909 71767 Tysnd1 http://www.ncbi.nlm.nih.gov/gene/?term=71767 1300019N10Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020910 7178 TPT1 http://www.ncbi.nlm.nih.gov/gene/?term=7178 "HRF, TCTP, p02, p23 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020911 71791 Cpa4 http://www.ncbi.nlm.nih.gov/gene/?term=71791 "1110019K20Rik, AV009555 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020912 71795 Pitpnc1 http://www.ncbi.nlm.nih.gov/gene/?term=71795 "1110020B03Rik, 5830436L09Rik, AI662802, AI851387, C330017I21Rik, Dnr411, RDGBB, RDGBB1, rdgB-beta " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020913 71799 Ptcd1 http://www.ncbi.nlm.nih.gov/gene/?term=71799 1110069M14Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020914 7179 TPTE http://www.ncbi.nlm.nih.gov/gene/?term=7179 "CT44, PTEN2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020915 717 C2 http://www.ncbi.nlm.nih.gov/gene/?term=717 "ARMD14, CO2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020916 71803 Slc25a18 http://www.ncbi.nlm.nih.gov/gene/?term=71803 "1500015I14Rik, AW125787 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020917 7180 CRISP2 http://www.ncbi.nlm.nih.gov/gene/?term=7180 "CRISP-2, CT36, GAPDL5, TPX1, TSP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020918 71811 2610027H17Rik http://www.ncbi.nlm.nih.gov/gene/?term=71811 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020919 71817 Tmem50a http://www.ncbi.nlm.nih.gov/gene/?term=71817 "3200001F09Rik, CAM, Smp1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020920 71819 Kif23 http://www.ncbi.nlm.nih.gov/gene/?term=71819 "3110001D19Rik, C87313, CHO1, Knsl5, MKLP-1, MKLP1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020921 7181 NR2C1 http://www.ncbi.nlm.nih.gov/gene/?term=7181 TR2 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020922 7181 NR2C1 http://www.ncbi.nlm.nih.gov/gene/?term=7181 TR2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020923 71820 Wdr34 http://www.ncbi.nlm.nih.gov/gene/?term=71820 3200002I06Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020924 71826 1700001F09Rik http://www.ncbi.nlm.nih.gov/gene/?term=71826 Gm10377 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020925 7182 NR2C2 http://www.ncbi.nlm.nih.gov/gene/?term=7182 "TAK1, TR4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020926 71832 Csl http://www.ncbi.nlm.nih.gov/gene/?term=71832 1700007H16Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020927 71833 Dcaf7 http://www.ncbi.nlm.nih.gov/gene/?term=71833 "1700012F10Rik, 2610037L01Rik, C86529, HAN11, Wdr68 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020928 71833 Dcaf7 http://www.ncbi.nlm.nih.gov/gene/?term=71833 "1700012F10Rik, 2610037L01Rik, C86529, HAN11, Wdr68 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020929 71834 Zbtb43 http://www.ncbi.nlm.nih.gov/gene/?term=71834 "1700010E06Rik, Zfp297b, mKIAA0414 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020930 71835 Lancl2 http://www.ncbi.nlm.nih.gov/gene/?term=71835 1700003F10Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020931 71841 Tcp11x2 http://www.ncbi.nlm.nih.gov/gene/?term=71841 "1700008I05Rik, C77164, TCP11, Tcp11l3 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020932 71843 R3hcc1 http://www.ncbi.nlm.nih.gov/gene/?term=71843 "1700020M16Rik, AA407796 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020933 71846 Syce2 http://www.ncbi.nlm.nih.gov/gene/?term=71846 "1700013H19Rik, AA407907, Cesc1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020934 7184 HSP90B1 http://www.ncbi.nlm.nih.gov/gene/?term=7184 "ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020935 7184 HSP90B1 http://www.ncbi.nlm.nih.gov/gene/?term=7184 "ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1 " mRNA Homo sapiens 12923260 Endoplasmic reticulum T-cell line Jurkat Northern blot "In this report, we use multiple cell fractionation protocols, in combination with cDNA microarray, nuclease protection, and Northern blot analyses, to assess the distribution of mRNAs between free and ER-bound ribosomes. We find a broad representation of mRNAs encoding soluble proteins in the ER fraction, with a subset of such mRNAs displaying substantial ER partitioning. In addition, we present evidence that membrane-bound ribosomes engage in the translation of mRNAs encoding soluble proteins. Single-cell in situ hybridization analysis of the subcellular distribution of mRNAs encoding ER-localized and soluble proteins identify two overall patterns of mRNA distribution in the cell-endoplasmic reticular and cytosolic. FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells. " RLID00020936 7184 HSP90B1 http://www.ncbi.nlm.nih.gov/gene/?term=7184 "ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1 " mRNA Homo sapiens 12923260 Endoplasmic reticulum Embryo - "These data were not unique to murine (NIH-3T3) cells; identical distribution patterns were observed in HEK293 cells, a human embryonic cell line (T. Zheng and C.V. Nicchitta, unpubl.). " RLID00020937 7184 HSP90B1 http://www.ncbi.nlm.nih.gov/gene/?term=7184 "ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1 " mRNA Homo sapiens 12923260 Ribosome T-cell line Jurkat S1 nuclease protection assays "Using the procedures described above, the subcellular distribution of individual mRNAs in the cytosol and rough ER polysome fractions of Jurkat and J558 cells was determined. mRNAs for resident proteins of the ER lumen, including BiP, calreticulin, and GRP94, were also highly enriched on membrane-bound polysomes. " RLID00020938 7184 HSP90B1 http://www.ncbi.nlm.nih.gov/gene/?term=7184 "ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1 " mRNA Homo sapiens 18192611 Ribosome HeLa cell Northern blot FIGURE 2. Subcellular mRNA distribution in SRP54 knock-down HeLa cell lines. (A) Total RNA from control HeLa (H) or SRP54 (54) stable knock-down cells was analyzed by Northern blot. (B) Cell surface expression of DR4 was determined by flow cytometry using no primary antibody (control) or DR4 antibody. (C) Cells were fractionated by sequential detergent extraction into cytosol (lane C) or membrane-bound (lane M) fractions. RNA isolated from total cells (lane T) or cell fractions was analyzed by Northern blot using the probes listed in Materials and Methods. Data are collected from Figure 2. RLID00020939 7184 HSP90B1 http://www.ncbi.nlm.nih.gov/gene/?term=7184 "ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1 " mRNA Homo sapiens 21431749 Endoplasmic reticulum HEK293 cell Northern blot "Similarly, Northern blot analysis of the mRNA composition of the cytosol and membrane fractions show that the cytosol fraction is enriched for mRNAs encoding histone (H3F3A) and GAPDH, whereas the membrane fraction is enriched in mRNAs encoding ER resident proteins, such as GRP94 and calreticulin (Fig. 2 B). " RLID00020940 7184 HSP90B1 http://www.ncbi.nlm.nih.gov/gene/?term=7184 "ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00020941 7184 HSP90B1 http://www.ncbi.nlm.nih.gov/gene/?term=7184 "ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020942 7184 HSP90B1 http://www.ncbi.nlm.nih.gov/gene/7184 "ECGP, GP96, TRA1, GRP94, HEL35, HEL-S-125m " mRNA Homo sapiens 25063809 Ribosome HeLa cell qRT-PCR Figure 1: Endoplasmic reticulum-associated mRNAs are partitioned between detergent-resistant and detergent-sensitive membrane domains. Data are collected from Figure 1. RLID00020943 7184 HSP90B1 http://www.ncbi.nlm.nih.gov/gene/?term=7184 "ECGP, GP96, TRA1, GRP94, HEL35, HEL-S-125m " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00020944 71853 Pdia6 http://www.ncbi.nlm.nih.gov/gene/?term=71853 "1700015E05Rik, AL023058, C77895, CaBP5, P5, Txndc7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020945 7185 TRAF1 http://www.ncbi.nlm.nih.gov/gene/?term=7185 "EBI6, MGC:10353 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020946 71865 Fbxo30 http://www.ncbi.nlm.nih.gov/gene/?term=71865 "1700026A16Rik, MUSA1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020947 7186 TRAF2 http://www.ncbi.nlm.nih.gov/gene/?term=7186 "MGC:45012, TRAP, TRAP3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020948 71870 Cfap45 http://www.ncbi.nlm.nih.gov/gene/?term=71870 "1700028D05Rik, Ccdc19, Nesg1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020949 71876 Cenpu http://www.ncbi.nlm.nih.gov/gene/?term=71876 "1700029A22Rik, Mlf1ip " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020950 7187 TRAF3 http://www.ncbi.nlm.nih.gov/gene/?term=7187 "CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020951 71888 Krt33a http://www.ncbi.nlm.nih.gov/gene/?term=71888 2310015J09Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020952 71889 Epn3 http://www.ncbi.nlm.nih.gov/gene/?term=71889 2310022G12Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020953 7188 TRAF5 http://www.ncbi.nlm.nih.gov/gene/?term=7188 "MGC:39780, RNF84 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020954 71891 Cdadc1 http://www.ncbi.nlm.nih.gov/gene/?term=71891 "2310010M10Rik, AI449174, AI463398, BB130816, NYD-SP15 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020955 7189 TRAF6 http://www.ncbi.nlm.nih.gov/gene/?term=7189 "MGC:3310, RNF85 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020956 71900 Tmem106b http://www.ncbi.nlm.nih.gov/gene/?term=71900 "2310036D22Rik, 5830455K21Rik, 6430519M21Rik, AI428776, AI661344 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020957 71901 Fam219a http://www.ncbi.nlm.nih.gov/gene/?term=71901 2310028H24Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020958 71902 Cand1 http://www.ncbi.nlm.nih.gov/gene/?term=71902 "2310038O07Rik, 6330512O03Rik, AI195005, AI846556, D10Ertd516e, Tp120a, mKIAA0829 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020959 71903 Ces2f http://www.ncbi.nlm.nih.gov/gene/?term=71903 "2310038E17Rik, A430088E12 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020960 71914 Antxr2 http://www.ncbi.nlm.nih.gov/gene/?term=71914 "2310046B19Rik, AW561899, CMG-2, CMG2, cI-35 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020961 71916 Dus4l http://www.ncbi.nlm.nih.gov/gene/?term=71916 "2310069P03Rik, 2700089B10Rik, AI482040, Pp35 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020962 71919 Rpap3 http://www.ncbi.nlm.nih.gov/gene/?term=71919 "2310042P20Rik, D15Ertd682e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020963 71920 Epgn http://www.ncbi.nlm.nih.gov/gene/?term=71920 "2310069M11Rik, epigen " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020964 71921 2310058N22Rik http://www.ncbi.nlm.nih.gov/gene/?term=71921 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020965 71923 Borcs6 http://www.ncbi.nlm.nih.gov/gene/?term=71923 2310047M10Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020966 71924 Tube1 http://www.ncbi.nlm.nih.gov/gene/?term=71924 "2310061K05Rik, AI551343, Tube " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020967 71927 Itfg1 http://www.ncbi.nlm.nih.gov/gene/?term=71927 "2310047C21Rik, AI314457, Cda08, D8Wsu49e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020968 71929 Tmem123 http://www.ncbi.nlm.nih.gov/gene/?term=71929 2310075C12Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020969 71934 Car13 http://www.ncbi.nlm.nih.gov/gene/?term=71934 "2310075C21Rik, Ca13 " mRNA Mus musculus 20820888 Cytosol Gland tissue qRT-PCR "In the present study, we examined the mRNA expression of all 13 enzymatically active CA isozymes by qRT-PCR in the mouse harderian gland. As shown in Fig. 1, nine of the 13 isozymes were detected in the harderian gland tissue at the mRNA level. Four isoforms were cytosolic (Car2, Car3, Car7, and Car13), three were membrane-associated (Car4, Car12, and Car15), one was mitochondrial (Car5b), and one was secreted (Car6). " RLID00020970 71946 Endod1 http://www.ncbi.nlm.nih.gov/gene/?term=71946 "2210414F18Rik, 2310067E08Rik, C85344 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020971 71952 2410016O06Rik http://www.ncbi.nlm.nih.gov/gene/?term=71952 "MAPJD, NO66 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020972 71956 Rnf135 http://www.ncbi.nlm.nih.gov/gene/?term=71956 "0610037N03Rik, 2410006N06Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020973 71960 Myh14 http://www.ncbi.nlm.nih.gov/gene/?term=71960 "2400004E04Rik, II-C, NHMCII, NMHC II-C " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020974 71962 Gatsl3 http://www.ncbi.nlm.nih.gov/gene/?term=71962 2410008K03Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020975 71963 Cdca4 http://www.ncbi.nlm.nih.gov/gene/?term=71963 "2410018C03Rik, HEPP, SEI-3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020976 71966 Nkiras2 http://www.ncbi.nlm.nih.gov/gene/?term=71966 "2410003M04Rik, 4930527H08Rik, D630018G21Rik, KBRAS2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020977 71971 Zswim1 http://www.ncbi.nlm.nih.gov/gene/?term=71971 "2410003H12Rik, AI850991, BB046916 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020978 71972 Dnmbp http://www.ncbi.nlm.nih.gov/gene/?term=71972 "2410003L07Rik, 2410003M15Rik, TUBA " mRNA Mus musculus 22817891 Cytoplasm Bone marrow Macrophage Next-generation sequencing "Cluster 11, by contrast, contains abundant cytoplasmic transcripts, with fewer transcripts in the chromatin and nucleoplasm. This cluster includes genes that are likely to encode highly stable mRNAs, such as Actb (beta-actin) and Tuba (alpha-tubulin). " RLID00020979 71981 Tdrd12 http://www.ncbi.nlm.nih.gov/gene/?term=71981 "2410004F06Rik, 2410070K17Rik, ECAT8, EG434165, G1-476-14, repro23 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020980 71983 Tmco6 http://www.ncbi.nlm.nih.gov/gene/?term=71983 2410015B03Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020981 71984 Sars2 http://www.ncbi.nlm.nih.gov/gene/?term=71984 "2410015F05Rik, D7Ertd353e, SerRS, SerRSmt " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020982 71985 Acad10 http://www.ncbi.nlm.nih.gov/gene/?term=71985 2410021P16Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020983 71988 Esco2 http://www.ncbi.nlm.nih.gov/gene/?term=71988 "2410004I17Rik, D030072L07Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020984 71 ACTG1 http://www.ncbi.nlm.nih.gov/gene/?term=71 "ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020985 71 ACTG1 http://www.ncbi.nlm.nih.gov/gene/?term=71 "ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020986 71 ACTG1 http://www.ncbi.nlm.nih.gov/gene/?term=71 "ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00020987 72007 Fndc3b http://www.ncbi.nlm.nih.gov/gene/?term=72007 "1600019O04Rik, AW550168, Fad104, mKIAA4164 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020988 7200 TRH http://www.ncbi.nlm.nih.gov/gene/?term=7200 "Pro-TRH, TRF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00020989 72012 1600020E01Rik http://www.ncbi.nlm.nih.gov/gene/?term=72012 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020990 72020 Zfp654 http://www.ncbi.nlm.nih.gov/gene/?term=72020 "1600021C16Rik, 1810008K20Rik, Znf654 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020991 72033 Tsc22d2 http://www.ncbi.nlm.nih.gov/gene/?term=72033 "1810043J12Rik, 5530402M19Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020992 72039 Mccc1 http://www.ncbi.nlm.nih.gov/gene/?term=72039 "1810045E08Rik, 2310058B18Rik, MCCalpha, Mcca, R75106 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020993 7203 CCT3 http://www.ncbi.nlm.nih.gov/gene/?term=7203 "CCT-gamma, CCTG, PIG48, TCP-1-gamma, TRIC5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020994 72042 Cotl1 http://www.ncbi.nlm.nih.gov/gene/?term=72042 "1810074P22Rik, 2010004C08Rik, Clp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020995 72047 Ddx42 http://www.ncbi.nlm.nih.gov/gene/?term=72047 "1810047H21Rik, AW319508, AW556242, B430002H05Rik, RHELP, RNAHP, SF3b125 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020996 72047 Ddx42 http://www.ncbi.nlm.nih.gov/gene/?term=72047 "1810047H21Rik, AW319508, AW556242, B430002H05Rik, RHELP, RNAHP, SF3b125 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00020997 7204 TRIO http://www.ncbi.nlm.nih.gov/gene/?term=7204 "ARHGEF23, tgat " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00020998 72050 Kdelc1 http://www.ncbi.nlm.nih.gov/gene/?term=72050 "1810049A15Rik, 5730416C13Rik, EP58, Kdel1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00020999 7205 TRIP6 http://www.ncbi.nlm.nih.gov/gene/?term=7205 "OIP-1, OIP1, TRIP-6i2, ZRP-1, TRIP6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021000 7205 TRIP6 http://www.ncbi.nlm.nih.gov/gene/?term=7205 "OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021001 72061 2010111I01Rik http://www.ncbi.nlm.nih.gov/gene/?term=72061 "2300006M17Rik, AP-O, Aopep, mir-23b, mir-24-1, mir-27b " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021002 72065 Rap2c http://www.ncbi.nlm.nih.gov/gene/?term=72065 "2010200P20Rik, AI194294, AL022976 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021003 72068 Cnot2 http://www.ncbi.nlm.nih.gov/gene/?term=72068 "2600016M12Rik, 2810470K03Rik, AA537049, AA959607, AW557563, C79650 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021004 7206 TRK-TTT3-5 http://www.ncbi.nlm.nih.gov/gene/?term=7206 "TRK-TTT3-4, TRK1, TRNAK1 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00021005 7206 TRK-TTT3-5 http://www.ncbi.nlm.nih.gov/gene/?term=7206 "TRK-TTT3-4, TRK1, TRNAK1 " tRNA Homo sapiens 25690653 Cytoplasm P493-6 cell qRT-PCR "To validate the isolation of nuclear and cytoplasmic fractions, the enrichment of 3 nuclear (ANRIL, MIAT, XIST) and 3 cytoplasmic (RPPH1, DANCR, tRNA-Lys) RNAs was analyzed by qRT-PCR. " RLID00021006 72074 Anks4b http://www.ncbi.nlm.nih.gov/gene/?term=72074 "2010013E14Rik, AI956809, Harp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021007 72083 Mzt2 http://www.ncbi.nlm.nih.gov/gene/?term=72083 "2410018G20Rik, 2610001E06Rik, Fam128, Fam128b " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021008 72085 Osgepl1 http://www.ncbi.nlm.nih.gov/gene/?term=72085 "2610001M19Rik, AA416452 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021009 72087 2010015M23Rik http://www.ncbi.nlm.nih.gov/gene/?term=72087 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021010 72091 Snhg7 http://www.ncbi.nlm.nih.gov/gene/?term=72091 "2610002F03Rik, AI427062 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021011 72096 Mettl10 http://www.ncbi.nlm.nih.gov/gene/?term=72096 2010208K18Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021012 72098 Tmem68 http://www.ncbi.nlm.nih.gov/gene/?term=72098 "2010300G19Rik, AA408325, AW123402 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021013 720 C4A http://www.ncbi.nlm.nih.gov/gene/?term=720 "C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021014 72107 Dscc1 http://www.ncbi.nlm.nih.gov/gene/?term=72107 "2010006I05Rik, 2600005O03Rik, Dcc1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021015 7210 TRX-CAT1-2 http://www.ncbi.nlm.nih.gov/gene/?term=7210 "RNTMI1, RNTMI2, RNTMT1, TRM1, TRM2, TRMI2, TRNAM1, TRNAMI2, TRX-CAT1-3 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00021016 72117 Naa50 http://www.ncbi.nlm.nih.gov/gene/?term=72117 "2600005K24Rik, 2810441M03Rik, AW112078, Mak3, Mak3p, Nat13, Nat5, San " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021017 72123 Ccdc71l http://www.ncbi.nlm.nih.gov/gene/?term=72123 "2010109K11Rik, AV375874 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021018 72124 Seh1l http://www.ncbi.nlm.nih.gov/gene/?term=72124 "2610007A16Rik, AW540070, SEC13L, SEH1A, SEH1B, Seh1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021019 72124 Seh1l http://www.ncbi.nlm.nih.gov/gene/?term=72124 "2610007A16Rik, AW540070, SEC13L, SEH1A, SEH1B, Seh1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021020 72129 Pex13 http://www.ncbi.nlm.nih.gov/gene/?term=72129 2610008O20Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021021 72131 2010310C07Rik http://www.ncbi.nlm.nih.gov/gene/?term=72131 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021022 72133 Trub1 http://www.ncbi.nlm.nih.gov/gene/?term=72133 "2610009I02Rik, 9030425C13Rik, AI448235, BB118943, C76870 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021023 72144 Slc37a3 http://www.ncbi.nlm.nih.gov/gene/?term=72144 "2610507O21Rik, AU044904 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021024 72148 Tdrp http://www.ncbi.nlm.nih.gov/gene/?term=72148 2610019F03Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021025 72154 Zfp157 http://www.ncbi.nlm.nih.gov/gene/?term=72154 "2610020C11Rik, A630094N24Rik, AI327407, mszf12, mszf23-1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021026 72155 Cenpn http://www.ncbi.nlm.nih.gov/gene/?term=72155 "2610510J17Rik, AI426416, AW545024 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021027 72175 Mfsd8 http://www.ncbi.nlm.nih.gov/gene/?term=72175 "2810423E13Rik, AI836898, AV142426, Cln7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021028 72183 Snx6 http://www.ncbi.nlm.nih.gov/gene/?term=72183 "2010006G21Rik, 2610032J07Rik, 2810425K19Rik, AU018928, C85963 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021029 72185 Dbndd1 http://www.ncbi.nlm.nih.gov/gene/?term=72185 "2810427I04Rik, D8Ertd590e " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021030 72193 Scaf11 http://www.ncbi.nlm.nih.gov/gene/?term=72193 "1110061H03Rik, 2610510E10Rik, AI462454, CASP11, SIP1, SRRP129, Sfrs2ip, Srsf2ip, mKIAA3013 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021031 72194 Fbxl20 http://www.ncbi.nlm.nih.gov/gene/?term=72194 "2610511F20Rik, 4632423N09Rik, AI849362, AL117906, C86145, Fbl2, Scr, mKIAA4147 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021032 72198 Skiv2l2 http://www.ncbi.nlm.nih.gov/gene/?term=72198 "2610528A15Rik, mKIAA0052 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021033 72207 1700003K11Rik http://www.ncbi.nlm.nih.gov/gene/?term=72207 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021034 7220 TRPC1 http://www.ncbi.nlm.nih.gov/gene/?term=7220 "HTRP-1, TRP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021035 7220 TRPC1 http://www.ncbi.nlm.nih.gov/gene/?term=7220 "HTRP-1, TRP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021036 72229 1700003G13Rik http://www.ncbi.nlm.nih.gov/gene/?term=72229 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021037 72242 Psg21 http://www.ncbi.nlm.nih.gov/gene/?term=72242 "1600019C01Rik, 1600025N01Rik, 1600026N13Rik, cea8 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021038 72245 1700018M17Rik http://www.ncbi.nlm.nih.gov/gene/?term=72245 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021039 72246 1700030C12Rik http://www.ncbi.nlm.nih.gov/gene/?term=72246 ENSMUSG00000073112 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021040 72258 Kcnk10 http://www.ncbi.nlm.nih.gov/gene/?term=72258 "1700024D23Rik, 3010005K24Rik, Trek2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021041 72265 Tram1 http://www.ncbi.nlm.nih.gov/gene/?term=72265 "1810049E02Rik, TRAMP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021042 72269 Cda http://www.ncbi.nlm.nih.gov/gene/?term=72269 2210401N16Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021043 7226 TRPM2 http://www.ncbi.nlm.nih.gov/gene/?term=7226 "EREG1, KNP3, LTRPC2, LTrpC-2, NUDT9H, NUDT9L1, TRPC7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021044 72278 Ccpg1 http://www.ncbi.nlm.nih.gov/gene/?term=72278 "1700030B06Rik, 1810073J13Rik, 9430028F23Rik, AI426686, AI875170, CPR8, D9Ertd392e " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021045 7227 TRPS1 http://www.ncbi.nlm.nih.gov/gene/?term=7227 "GC79, LGCR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021046 72289 Malat1 http://www.ncbi.nlm.nih.gov/gene/?term=72289 "2210401K01Rik, 9430072K23Rik, AI647968, Neat2 " lncRNA Mus musculus 17270048 Nucleus Liver cell In situ hybridization "In both the BLK CL.4 cell line and mouse liver, both Neat1 and Neat2/Malat-1 were both more than ten-fold enriched in nuclear fractions (Table ?(Table1).1) " RLID00021047 72289 Malat1 http://www.ncbi.nlm.nih.gov/gene/?term=72289 "2210401K01Rik, 9430072K23Rik, AI647968, Neat2 " lncRNA Mus musculus 20729808 Nucleus Bone osteosarcoma epithelial cell Microarray Malat1 RNA is expressed in numerous tissues and is highly abundant in neurons. It is enriched in nuclear speckles only when RNA polymerase II-dependent transcription is active. RLID00021048 72289 Malat1 http://www.ncbi.nlm.nih.gov/gene/?term=72289 "2210401K01Rik, 9430072K23Rik, AI647968, Neat2 " lncRNA Mus musculus 22817891 Nucleus Bone marrow Macrophage Next-generation sequencing "Cluster 7, for example, contains abundant transcripts in the chromatin, with much lower transcript levels in the nucleoplasm and cytoplasm relative to the other clusters. This cluster is dominated by annotated and unannotated non-coding transcripts and miRNA precursors. (The analysis excluded transcripts shorter than 400 nucleotides and therefore excluded mature miRNAs and many miRNA precursors.) Some non-coding RNAs, such as Xist, are highly enriched in the chromatin because they function at this location (Figure S2). Examples of other non-coding RNAs in Cluster 7 are Neat1 and Malat1/Neat2 (Figure S2). Further mining of the data sets may provide insights into the subcellular locations at which many non-coding RNAs function. Cluster 7 also includes transcripts from constitutive protein-coding genes that may be highly unstable and therefore present at low levels in the cytoplasm (e.g. Leng8 in Figure S2). " RLID00021049 72289 Malat1 http://www.ncbi.nlm.nih.gov/gene/?term=72289 "2210401K01Rik, 9430072K23Rik, AI647968, Neat2 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021050 72289 Malat1 http://www.ncbi.nlm.nih.gov/gene/?term=72289 "2210401K01Rik, 9430072K23Rik, AI647968, Neat2 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021051 72289 Malat1 http://www.ncbi.nlm.nih.gov/gene/?term=72289 "2210401K01Rik, 9430072K23Rik, AI647968, Neat2 " lncRNA Mus musculus 22718948 Nucleus Embryotem cell In situ hybridization|Northern blot|qRT-PCR "Malat1 localizes to one type of these nuclear bodies, known as nuclear speckles, which contain various pre-mRNA splicing regulators, including uridine-rich small nuclear RNA-protein complexes (UsnRNPs) and the serine- and arginine-rich (SR) family of splicing factors, which are involved in exon recognition and alternative splicing (for review, see Hall et al. 2006; Spector and Lamond 2011). " RLID00021052 72289 Malat1 http://www.ncbi.nlm.nih.gov/gene/?term=72289 "2210401K01Rik, 9430072K23Rik, AI647968, Neat2 " lncRNA Mus musculus 26464439 Axon Motoneuron In situ hybridization|qRT-PCR "We then analyzed the abundance of several lncRNAs, namely Malat1, Meg3, Rmst, Xist and Miat. All of these lncRNAs were present in the axonal compartment. " RLID00021053 722 C4BPA http://www.ncbi.nlm.nih.gov/gene/?term=722 "C4BP, PRP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021054 72301 1810041L15Rik http://www.ncbi.nlm.nih.gov/gene/?term=72301 Kiaa1644 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021055 72313 Fryl http://www.ncbi.nlm.nih.gov/gene/?term=72313 "2010313D22Rik, 2310004H21Rik, 2510002A14Rik, 9030227G01Rik, mKIAA0826 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021056 72313 Fryl http://www.ncbi.nlm.nih.gov/gene/?term=72313 "2010313D22Rik, 2310004H21Rik, 2510002A14Rik, 9030227G01Rik, mKIAA0826 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021057 7231 TRR-ACG1-2 http://www.ncbi.nlm.nih.gov/gene/?term=7231 "TRNAR2, TRR-ACG1-3, TRR2 " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00021058 72323 Asb6 http://www.ncbi.nlm.nih.gov/gene/?term=72323 "2510004M11Rik, AA409356 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021059 72333 Palld http://www.ncbi.nlm.nih.gov/gene/?term=72333 "2410003B16Rik, 6030492A02 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021060 72333 Palld http://www.ncbi.nlm.nih.gov/gene/?term=72333 "2410003B16Rik, 6030492A02 " mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00021061 72341 Elp6 http://www.ncbi.nlm.nih.gov/gene/?term=72341 "2610001P13Rik, 2610002I17Rik, AV159994, Tmem103 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021062 72343 2600002B07Rik http://www.ncbi.nlm.nih.gov/gene/?term=72343 AI586157 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021063 72344 Usp36 http://www.ncbi.nlm.nih.gov/gene/?term=72344 "2700002L06Rik, mKIAA1453 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021064 72349 Dusp3 http://www.ncbi.nlm.nih.gov/gene/?term=72349 "2210015O03Rik, 5031436O03Rik, T-DSP11, VHR " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021065 7234 TRU-TCA1-1 http://www.ncbi.nlm.nih.gov/gene/?term=7234 "TRNAU1, TRSP, tRNA(Sec) " tRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00021066 72357 2210016L21Rik http://www.ncbi.nlm.nih.gov/gene/?term=72357 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021067 72399 Brap http://www.ncbi.nlm.nih.gov/gene/?term=72399 "3010002G07Rik, BRAP2, IMP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021068 72415 Sgol1 http://www.ncbi.nlm.nih.gov/gene/?term=72415 "3300001M08Rik, C81037, Sgo1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021069 72429 Dnajc25 http://www.ncbi.nlm.nih.gov/gene/?term=72429 "2010109C08Rik, 2010203O07Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021070 72433 Rab38 http://www.ncbi.nlm.nih.gov/gene/?term=72433 "2310011F14Rik, AU043391, cht " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021071 72454 Ccdc71 http://www.ncbi.nlm.nih.gov/gene/?term=72454 2600016J21Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021072 72459 Htatsf1 http://www.ncbi.nlm.nih.gov/gene/?term=72459 "1600023H17Rik, 2600017A12Rik, 2700077B20Rik, TAT-SF1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021073 72462 Rrp1b http://www.ncbi.nlm.nih.gov/gene/?term=72462 "2600005C20Rik, D030064A17, Kiaa0179, mKIAA0179 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021074 72477 Tmem87b http://www.ncbi.nlm.nih.gov/gene/?term=72477 "2610301K12Rik, 2810431I02Rik, AU014804 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021075 7247 TSN http://www.ncbi.nlm.nih.gov/gene/?term=7247 "BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021076 7247 TSN http://www.ncbi.nlm.nih.gov/gene/?term=7247 "BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021077 7247 TSN http://www.ncbi.nlm.nih.gov/gene/?term=7247 "BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021078 72480 Tspyl4 http://www.ncbi.nlm.nih.gov/gene/?term=72480 "2610102M01Rik, B230210I21Rik, D10Bwg0791e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021079 72482 Acbd6 http://www.ncbi.nlm.nih.gov/gene/?term=72482 "0610010G04Rik, 2610100E10Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021080 7248 TSC1 http://www.ncbi.nlm.nih.gov/gene/?term=7248 "LAM, TSC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021081 72493 2610202C22Rik http://www.ncbi.nlm.nih.gov/gene/?term=72493 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021082 7249 TSC2 http://www.ncbi.nlm.nih.gov/gene/?term=7249 "LAM, PPP1R160, TSC4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021083 72504 Taf4b http://www.ncbi.nlm.nih.gov/gene/?term=72504 "105kDa, 2610524B04Rik, 4932409F03Rik, AW987595, TAFII-105, TAFII105, Taf2c2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021084 72511 2610316D01Rik http://www.ncbi.nlm.nih.gov/gene/?term=72511 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021085 72515 Wdr43 http://www.ncbi.nlm.nih.gov/gene/?term=72515 "2610318G08Rik, AU020887, AV024208, Wrd43, mKIAA0007 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021086 7251 TSG101 http://www.ncbi.nlm.nih.gov/gene/?term=7251 "TSG10, VPS23 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021087 7251 TSG101 http://www.ncbi.nlm.nih.gov/gene/?term=7251 "TSG10, VPS23 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021088 7251 TSG101 http://www.ncbi.nlm.nih.gov/gene/?term=7251 "TSG10, VPS23 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021089 72535 Aldh1b1 http://www.ncbi.nlm.nih.gov/gene/?term=72535 2700007F14Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021090 72539 2700008E08Rik http://www.ncbi.nlm.nih.gov/gene/?term=72539 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021091 72545 2700008G24Rik http://www.ncbi.nlm.nih.gov/gene/?term=72545 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021092 72560 Naalad2 http://www.ncbi.nlm.nih.gov/gene/?term=72560 "2700022G20Rik, D9Ertd285e, Folh1b, GCP3, GCPIII, NAADALASE2, NAALADASE2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021093 72567 Bclaf1 http://www.ncbi.nlm.nih.gov/gene/?term=72567 "2610102K23Rik, 2700025J07Rik, 2810454G14Rik, 5730534O06Rik, AI450190, AW556225, Btf, mKIAA0164 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021094 72568 Lin9 http://www.ncbi.nlm.nih.gov/gene/?term=72568 "2700022J23Rik, Bara, Lin-9, TGS, TGS1, mLin-9 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021095 72569 Bbs5 http://www.ncbi.nlm.nih.gov/gene/?term=72569 "1700049I01Rik, 2700023J09Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021096 7257 TSNAX http://www.ncbi.nlm.nih.gov/gene/?term=7257 TRAX mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021097 7257 TSNAX http://www.ncbi.nlm.nih.gov/gene/?term=7257 TRAX mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021098 72584 Cul4b http://www.ncbi.nlm.nih.gov/gene/?term=72584 "2700050M05Rik, AA409770, CUL-4B, mKIAA0695 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021099 72585 Lypd1 http://www.ncbi.nlm.nih.gov/gene/?term=72585 "2700050C12Rik, AI853408, C530008O16Rik, Lynx2, Lypdc1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021100 72599 Pdia5 http://www.ncbi.nlm.nih.gov/gene/?term=72599 "2700053F16Rik, AU015525, Pdir " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021101 7259 TSPYL1 http://www.ncbi.nlm.nih.gov/gene/?term=7259 TSPYL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021102 7259 TSPYL1 http://www.ncbi.nlm.nih.gov/gene/?term=7259 TSPYL mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021103 7259 TSPYL1 http://www.ncbi.nlm.nih.gov/gene/?term=7259 TSPYL mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021104 7259 TSPYL1 http://www.ncbi.nlm.nih.gov/gene/?term=7259 TSPYL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021105 72605 Car10 http://www.ncbi.nlm.nih.gov/gene/?term=72605 "2700029L05Rik, BB085816, Ca10 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021106 72607 Usp13 http://www.ncbi.nlm.nih.gov/gene/?term=72607 "2700071E21Rik, AI848077, ISOT3, IsoT-3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021107 7260 TSSC1 http://www.ncbi.nlm.nih.gov/gene/?term=7260 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021108 7260 TSSC1 http://www.ncbi.nlm.nih.gov/gene/?term=7260 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021109 72611 Zfp655 http://www.ncbi.nlm.nih.gov/gene/?term=72611 "2700038I16Rik, 9030409O18Rik, mKIAA4222 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021110 72612 2700029M09Rik http://www.ncbi.nlm.nih.gov/gene/?term=72612 C230006B22Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021111 72621 Pdzd11 http://www.ncbi.nlm.nih.gov/gene/?term=72621 "1810012H22Rik, 2310079D11Rik, 2700099C19Rik, AI854765, Pdzk11 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021112 7262 PHLDA2 http://www.ncbi.nlm.nih.gov/gene/?term=7262 "BRW1C, BWR1C, HLDA2, IPL, TSSC3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021113 7262 PHLDA2 http://www.ncbi.nlm.nih.gov/gene/?term=7262 "BRW1C, BWR1C, HLDA2, IPL, TSSC3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021114 72634 Tdrkh http://www.ncbi.nlm.nih.gov/gene/?term=72634 "2700091C21Rik, Tdrd2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021115 7263 TST http://www.ncbi.nlm.nih.gov/gene/?term=7263 RDS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021116 7263 TST http://www.ncbi.nlm.nih.gov/gene/?term=7263 RDS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021117 72649 Tmem209 http://www.ncbi.nlm.nih.gov/gene/?term=72649 "2700094F01Rik, AI428435 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021118 7264 TSTA3 http://www.ncbi.nlm.nih.gov/gene/?term=7264 "FX, P35B, SDR4E1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021119 7264 TSTA3 http://www.ncbi.nlm.nih.gov/gene/?term=7264 "FX, P35B, SDR4E1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021120 72650 2810006K23Rik http://www.ncbi.nlm.nih.gov/gene/?term=72650 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021121 72654 Ccdc12 http://www.ncbi.nlm.nih.gov/gene/?term=72654 "2700094L05Rik, C76605 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021122 72655 Snhg5 http://www.ncbi.nlm.nih.gov/gene/?term=72655 "2810026P18Rik, 4933428I09Rik, mU50HG-b " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021123 72656 Ints8 http://www.ncbi.nlm.nih.gov/gene/?term=72656 "2810013E07Rik, AV063769, D130008D20Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021124 72658 2700097O09Rik http://www.ncbi.nlm.nih.gov/gene/?term=72658 AW552125 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021125 7265 TTC1 http://www.ncbi.nlm.nih.gov/gene/?term=7265 TPR1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021126 7265 TTC1 http://www.ncbi.nlm.nih.gov/gene/?term=7265 TPR1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021127 72662 Dis3 http://www.ncbi.nlm.nih.gov/gene/?term=72662 2810028N01Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021128 72666 2810047J09Rik http://www.ncbi.nlm.nih.gov/gene/?term=72666 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021129 72667 Zfp444 http://www.ncbi.nlm.nih.gov/gene/?term=72667 "2810031J10Rik, 6230401O10Rik, mFLJ00134 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021130 72669 2810032G03Rik http://www.ncbi.nlm.nih.gov/gene/?term=72669 AI461720 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021131 7266 DNAJC7 http://www.ncbi.nlm.nih.gov/gene/?term=7266 "DJ11, DJC7, TPR2, TTC2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021132 72674 Adipor1 http://www.ncbi.nlm.nih.gov/gene/?term=72674 "2810031L11Rik, ACDCR1, CGI-45, Paqr1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021133 7267 TTC3 http://www.ncbi.nlm.nih.gov/gene/?term=7267 "DCRR1, RNF105, TPRDIII " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021134 72692 Hnrnpll http://www.ncbi.nlm.nih.gov/gene/?term=72692 "2510028H02Rik, 2810036L13Rik, AI256697, AI852082, Hnrpll " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021135 72697 2810043O03Rik http://www.ncbi.nlm.nih.gov/gene/?term=72697 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021136 72699 Lime1 http://www.ncbi.nlm.nih.gov/gene/?term=72699 "2810038K19Rik, LIME " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021137 726 CAPN5 http://www.ncbi.nlm.nih.gov/gene/?term=726 "ADNIV, HTRA3, VRNI, nCL-3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021138 72713 Angptl1 http://www.ncbi.nlm.nih.gov/gene/?term=72713 "2810039D03Rik, ANG3, ANGPT3, ANGY, ARP1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021139 72716 2810047C21Rik1 http://www.ncbi.nlm.nih.gov/gene/?term=72716 "100042870, 2810047C21Rik, AA683836, Gm4082 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021140 72720 Zfp248 http://www.ncbi.nlm.nih.gov/gene/?term=72720 "2810037F07Rik, E130106N01Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021141 72723 Zfp74 http://www.ncbi.nlm.nih.gov/gene/?term=72723 "2810054M15Rik, KRAB8, Zfp66, Znf569, mszf21, mszf77 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021142 72727 B3gat3 http://www.ncbi.nlm.nih.gov/gene/?term=72727 2810405M13Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021143 72735 Eldr http://www.ncbi.nlm.nih.gov/gene/?term=72735 "2810442I21Rik, 4930500E12Rik, Fabl " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021144 72739 Zkscan3 http://www.ncbi.nlm.nih.gov/gene/?term=72739 "2810435N07Rik, AA408594, AI132359, Skz1, Zf47, Zfp-47, Zfp306, Zfp307, mszf35 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021145 7273 TTN http://www.ncbi.nlm.nih.gov/gene/?term=7273 "CMD1G, CMH9, CMPD4, EOMFC, HMERF, LGMD2J, MYLK5, TMD " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021146 7273 TTN http://www.ncbi.nlm.nih.gov/gene/?term=7273 "CMD1G, CMH9, CMPD4, EOMFC, HMERF, LGMD2J, MYLK5, TMD " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021147 72745 Tmem161b http://www.ncbi.nlm.nih.gov/gene/?term=72745 "2810446P07Rik, AI843389 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021148 72748 Hdhd3 http://www.ncbi.nlm.nih.gov/gene/?term=72748 2810435D12Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021149 72759 Tmem135 http://www.ncbi.nlm.nih.gov/gene/?term=72759 "2810439K08Rik, AW319712, PMP52 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021150 727676 SNORD118 http://www.ncbi.nlm.nih.gov/gene/?term=727676 U8 snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00021151 727676 SNORD118 http://www.ncbi.nlm.nih.gov/gene/?term=727676 U8 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021152 727676 SNORD118 http://www.ncbi.nlm.nih.gov/gene/?term=727676 U8 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021153 72772 Rint1 http://www.ncbi.nlm.nih.gov/gene/?term=72772 "1500019C06Rik, 2810450M21Rik, Rint-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021154 72775 Fance http://www.ncbi.nlm.nih.gov/gene/?term=72775 "2810451D06Rik, AI415634, AW209126 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021155 7277 TUBA4A http://www.ncbi.nlm.nih.gov/gene/?term=7277 "ALS22, H2-ALPHA, TUBA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021156 7277 TUBA4A http://www.ncbi.nlm.nih.gov/gene/?term=7277 "ALS22, H2-ALPHA, TUBA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021157 72787 Ndc1 http://www.ncbi.nlm.nih.gov/gene/?term=72787 "2810475A17Rik, AI450313, Tmem48, sks " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021158 727897 MUC5B http://www.ncbi.nlm.nih.gov/gene/?term=727897 "MG1, MUC-5B, MUC5, MUC9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021159 727940 RHOXF2B http://www.ncbi.nlm.nih.gov/gene/?term=727940 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021160 72801 2810488O17Rik http://www.ncbi.nlm.nih.gov/gene/?term=72801 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021161 7280 TUBB2A http://www.ncbi.nlm.nih.gov/gene/?term=7280 "CDCBM5, TUBB, TUBB2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021162 72820 2810461L16Rik http://www.ncbi.nlm.nih.gov/gene/?term=72820 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021163 72825 Mon1a http://www.ncbi.nlm.nih.gov/gene/?term=72825 2810468K17Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021164 72826 Fam76b http://www.ncbi.nlm.nih.gov/gene/?term=72826 "2810485I05Rik, C78303 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021165 72828 Ubash3b http://www.ncbi.nlm.nih.gov/gene/?term=72828 "2810457I06Rik, BB125008, TULA-2, p70 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021166 728294 D2HGDH http://www.ncbi.nlm.nih.gov/gene/?term=728294 D2HGD mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021167 7283 TUBG1 http://www.ncbi.nlm.nih.gov/gene/?term=7283 "CDCBM4, GCP-1, TUBG, TUBGCP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021168 7283 TUBG1 http://www.ncbi.nlm.nih.gov/gene/?term=7283 "CDCBM4, GCP-1, TUBG, TUBGCP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021169 7283 TUBG1 http://www.ncbi.nlm.nih.gov/gene/?term=7283 "CDCBM4, GCP-1, TUBG, TUBGCP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021170 728409 LINC01548 http://www.ncbi.nlm.nih.gov/gene/?term=728409 C21orf54 lncRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00021171 728448 PPIEL http://www.ncbi.nlm.nih.gov/gene/?term=728448 PPIEP1 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021172 728464 METTL24 http://www.ncbi.nlm.nih.gov/gene/?term=728464 "C6orf186, dJ71D21.2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021173 728464 METTL24 http://www.ncbi.nlm.nih.gov/gene/?term=728464 "C6orf186, dJ71D21.2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021174 728492 SERF1B http://www.ncbi.nlm.nih.gov/gene/?term=728492 "FAM2B, H4F5C, h4F5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021175 728492 SERF1B http://www.ncbi.nlm.nih.gov/gene/?term=728492 "FAM2B, H4F5C, h4F5 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021176 728492 SERF1B http://www.ncbi.nlm.nih.gov/gene/?term=728492 "FAM2B, H4F5C, h4F5 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021177 728492 SERF1B http://www.ncbi.nlm.nih.gov/gene/?term=728492 "FAM2B, H4F5C, h4F5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021178 7284 TUFM http://www.ncbi.nlm.nih.gov/gene/?term=7284 "COXPD4, EF-TuMT, EFTU, P43 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021179 728509 RPS19P7 http://www.ncbi.nlm.nih.gov/gene/?term=728509 RPS19_3_1038 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021180 728568 C12orf73 http://www.ncbi.nlm.nih.gov/gene/?term=728568 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021181 728577 CNTNAP3B http://www.ncbi.nlm.nih.gov/gene/?term=728577 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021182 728609 SDHAP3 http://www.ncbi.nlm.nih.gov/gene/?term=728609 "SDHACL, SDHAL " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021183 728621 CCDC30 http://www.ncbi.nlm.nih.gov/gene/?term=728621 "PFD6L, PFDN6L " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021184 728621 CCDC30 http://www.ncbi.nlm.nih.gov/gene/?term=728621 "PFD6L, PFDN6L " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021185 728655 HULC http://www.ncbi.nlm.nih.gov/gene/?term=728655 "HCCAT1, LINC00078, NCRNA00078 " lncRNA Homo sapiens 17241883 Cytoplasm Hepatoma cell qRT-PCR|Next generation sequencing "HULC is present in the cytoplasm, where it copurifies with ribosomes. siRNA-mediated knockdown of HULC RNA in 2 HCC cell lines altered the expression of several genes, 5 of which were known to be affected in HCC, suggesting a role for HULC in post-transcriptional modulation of gene expression. " RLID00021186 728655 HULC http://www.ncbi.nlm.nih.gov/gene/?term=728655 "HCCAT1, LINC00078, NCRNA00078 " lncRNA Homo sapiens 25332394 Cytoplasm - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/HULC/ RLID00021187 72865 Cxx1c http://www.ncbi.nlm.nih.gov/gene/?term=72865 "2900027G03Rik, Mar8.1, Mart8a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021188 728661 SLC35E2B http://www.ncbi.nlm.nih.gov/gene/?term=728661 SLC35E2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021189 728661 SLC35E2B http://www.ncbi.nlm.nih.gov/gene/?term=728661 SLC35E2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021190 728689 EIF3CL http://www.ncbi.nlm.nih.gov/gene/?term=728689 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021191 728689 EIF3CL http://www.ncbi.nlm.nih.gov/gene/?term=728689 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021192 7286 TUFT1 http://www.ncbi.nlm.nih.gov/gene/?term=7286 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021193 7286 TUFT1 http://www.ncbi.nlm.nih.gov/gene/?term=7286 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021194 7286 TUFT1 http://www.ncbi.nlm.nih.gov/gene/?term=7286 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021195 72873 Bbof1 http://www.ncbi.nlm.nih.gov/gene/?term=72873 "2900006K08Rik, AI427784, Ccdc176 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021196 728819 C1GALT1C1L http://www.ncbi.nlm.nih.gov/gene/?term=728819 mRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00021197 728819 C1GALT1C1L http://www.ncbi.nlm.nih.gov/gene/?term=728819 mRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00021198 728841 NBPF8 http://www.ncbi.nlm.nih.gov/gene/?term=728841 NBPF8P mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021199 72892 2900018K06Rik http://www.ncbi.nlm.nih.gov/gene/?term=72892 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021200 728953 RPS19P3 http://www.ncbi.nlm.nih.gov/gene/?term=728953 RPS19_4_1350 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021201 72895 Setd5 http://www.ncbi.nlm.nih.gov/gene/?term=72895 "2900045N06Rik, C330007C20, C85544, mKIAA1757 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021202 7289 TULP3 http://www.ncbi.nlm.nih.gov/gene/?term=7289 TUBL3 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021203 729082 OIP5-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=729082 cyrano lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021204 7290 HIRA http://www.ncbi.nlm.nih.gov/gene/?term=7290 "DGCR1, TUP1, TUPLE1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021205 72915 2900017F05Rik http://www.ncbi.nlm.nih.gov/gene/?term=72915 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021206 729359 PLIN4 http://www.ncbi.nlm.nih.gov/gene/?term=729359 "KIAA1881, S3-12 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021207 72937 2900008C10Rik http://www.ncbi.nlm.nih.gov/gene/?term=72937 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021208 729396 GAGE12J http://www.ncbi.nlm.nih.gov/gene/?term=729396 GAGE11 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021209 72940 2900022M12Rik http://www.ncbi.nlm.nih.gov/gene/?term=72940 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021210 729422 GAGE12C http://www.ncbi.nlm.nih.gov/gene/?term=729422 GAGE-12B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021211 729431 GAGE12E http://www.ncbi.nlm.nih.gov/gene/?term=729431 GAGE-12B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021212 729442 GAGE12H http://www.ncbi.nlm.nih.gov/gene/?term=729442 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021213 729447 GAGE2A http://www.ncbi.nlm.nih.gov/gene/?term=729447 "CT4.2, GAGE-2, GAGE-2A, GAGE2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021214 72949 Ccnt2 http://www.ncbi.nlm.nih.gov/gene/?term=72949 "2900041I18Rik, C81304, CycT2, CycT2a, CycT2b " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021215 729515 TMEM242 http://www.ncbi.nlm.nih.gov/gene/?term=729515 "BM033, C6orf35 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021216 729515 TMEM242 http://www.ncbi.nlm.nih.gov/gene/?term=729515 "BM033, C6orf35 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021217 729540 RGPD6 http://www.ncbi.nlm.nih.gov/gene/?term=729540 "RGP6, RGPD7, RanBP2L1, RanBP2L2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021218 729540 RGPD6 http://www.ncbi.nlm.nih.gov/gene/?term=729540 "RGP6, RGPD7, RanBP2L1, RanBP2L2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021219 72958 Zfp493 http://www.ncbi.nlm.nih.gov/gene/?term=72958 "2900054J07Rik, Rslcan12 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021220 7295 TXN http://www.ncbi.nlm.nih.gov/gene/?term=7295 "TRDX, TRX, TRX1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021221 729614 FLJ37453 http://www.ncbi.nlm.nih.gov/gene/?term=729614 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021222 72962 Tymp http://www.ncbi.nlm.nih.gov/gene/?term=72962 "2900072D10Rik, Ecgf1, PD-ECGF, PDECGF, Pdgfec " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021223 729648 ZNF812P http://www.ncbi.nlm.nih.gov/gene/?term=729648 ZNF812 lncRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021224 729665 CCDC175 http://www.ncbi.nlm.nih.gov/gene/?term=729665 "C14orf38, c14_5395 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021225 7296 TXNRD1 http://www.ncbi.nlm.nih.gov/gene/?term=7296 "GRIM-12, TR, TR1, TRXR1, TXNR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021226 7296 TXNRD1 http://www.ncbi.nlm.nih.gov/gene/?term=7296 "GRIM-12, TR, TR1, TRXR1, TXNR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021227 7296 TXNRD1 http://www.ncbi.nlm.nih.gov/gene/?term=7296 "GRIM-12, TR, TR1, TRXR1, TXNR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021228 7297 TYK2 http://www.ncbi.nlm.nih.gov/gene/?term=7297 "IMD35, JTK1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021229 7297 TYK2 http://www.ncbi.nlm.nih.gov/gene/?term=7297 "IMD35, JTK1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021230 72983 2900052O17Rik http://www.ncbi.nlm.nih.gov/gene/?term=72983 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021231 729852 UMAD1 http://www.ncbi.nlm.nih.gov/gene/?term=729852 "RPA3-AS1, RPA3OS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021232 72987 2900057C01Rik http://www.ncbi.nlm.nih.gov/gene/?term=72987 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021233 72989 2900074G08Rik http://www.ncbi.nlm.nih.gov/gene/?term=72989 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021234 7298 TYMS http://www.ncbi.nlm.nih.gov/gene/?term=7298 "HST422, TMS, TS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021235 7298 TYMS http://www.ncbi.nlm.nih.gov/gene/?term=7298 "HST422, TMS, TS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021236 729948 CDC26P1 http://www.ncbi.nlm.nih.gov/gene/?term=729948 CDC26P lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021237 729956 SHISA7 http://www.ncbi.nlm.nih.gov/gene/?term=729956 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021238 729967 MORN2 http://www.ncbi.nlm.nih.gov/gene/?term=729967 "BLOCK27, MOPT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021239 729991 BORCS8 http://www.ncbi.nlm.nih.gov/gene/?term=729991 MEF2BNB mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021240 72999 Insig2 http://www.ncbi.nlm.nih.gov/gene/?term=72999 "2900053I11Rik, C730043J18Rik, Insig-2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021241 72 ACTG2 http://www.ncbi.nlm.nih.gov/gene/?term=72 "ACT, ACTA3, ACTE, ACTL3, ACTSG, VSCM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021242 73008 2900073C16Rik http://www.ncbi.nlm.nih.gov/gene/?term=73008 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021243 730092 RRN3P1 http://www.ncbi.nlm.nih.gov/gene/?term=730092 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021244 730094 C16orf52 http://www.ncbi.nlm.nih.gov/gene/?term=730094 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021245 730101 LOC730101 http://www.ncbi.nlm.nih.gov/gene/?term=730101 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021246 7301 TYRO3 http://www.ncbi.nlm.nih.gov/gene/?term=7301 "BYK, Dtk, Etk-2, RSE, Rek, Sky, Tif " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021247 73020 2900073C17Rik http://www.ncbi.nlm.nih.gov/gene/?term=73020 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021248 73032 Ttc9b http://www.ncbi.nlm.nih.gov/gene/?term=73032 2900074C18Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021249 730394 GTF2H2C_2 http://www.ncbi.nlm.nih.gov/gene/?term=730394 GTF2H2D mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021250 730394 GTF2H2C_2 http://www.ncbi.nlm.nih.gov/gene/?term=730394 GTF2H2D mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021251 73047 Camk2n2 http://www.ncbi.nlm.nih.gov/gene/?term=73047 2900075A18Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021252 7305 TYROBP http://www.ncbi.nlm.nih.gov/gene/?term=7305 "DAP12, KARAP, PLOSL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021253 7307 U2AF1 http://www.ncbi.nlm.nih.gov/gene/?term=7307 "FP793, RN, RNU2AF1, U2AF35, U2AFBP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021254 7307 U2AF1 http://www.ncbi.nlm.nih.gov/gene/?term=7307 "FP793, RN, RNU2AF1, U2AF35, U2AFBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021255 73080 2900084O13Rik http://www.ncbi.nlm.nih.gov/gene/?term=73080 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021256 73082 3100003M19Rik http://www.ncbi.nlm.nih.gov/gene/?term=73082 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021257 73093 3110006O06Rik http://www.ncbi.nlm.nih.gov/gene/?term=73093 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021258 730 C7 http://www.ncbi.nlm.nih.gov/gene/?term=730 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021259 73100 2900092D14Rik http://www.ncbi.nlm.nih.gov/gene/?term=73100 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021260 7311 UBA52 http://www.ncbi.nlm.nih.gov/gene/?term=7311 "CEP52, HUBCEP52, L40, RPL40 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021261 7311 UBA52 http://www.ncbi.nlm.nih.gov/gene/?term=7311 "CEP52, HUBCEP52, L40, RPL40 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021262 7311 UBA52 http://www.ncbi.nlm.nih.gov/gene/?term=7311 "CEP52, HUBCEP52, L40, RPL40 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021263 7311 UBA52 http://www.ncbi.nlm.nih.gov/gene/?term=7311 "CEP52, HUBCEP52, L40, RPL40 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021264 73121 Fam101a http://www.ncbi.nlm.nih.gov/gene/?term=73121 "3110032G18Rik, cfm, cfm2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021265 73130 Tmed5 http://www.ncbi.nlm.nih.gov/gene/?term=73130 "3110020O18Rik, 4432412D15Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021266 73130 Tmed5 http://www.ncbi.nlm.nih.gov/gene/?term=73130 "3110020O18Rik, 4432412D15Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021267 73137 Prrc1 http://www.ncbi.nlm.nih.gov/gene/?term=73137 "1190002C06Rik, 2310058D16Rik, 3110038B19Rik, 9430085A19Rik " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021268 73137 Prrc1 http://www.ncbi.nlm.nih.gov/gene/?term=73137 "1190002C06Rik, 2310058D16Rik, 3110038B19Rik, 9430085A19Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021269 73139 Cenpv http://www.ncbi.nlm.nih.gov/gene/?term=73139 "3110013H01Rik, AA671303, Prr6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021270 7314 UBB http://www.ncbi.nlm.nih.gov/gene/?term=7314 HEL-S-50 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021271 73158 Larp1 http://www.ncbi.nlm.nih.gov/gene/?term=73158 "1810024J12Rik, 3110040D16Rik, Larp, mKIAA0731 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021272 73162 Otud3 http://www.ncbi.nlm.nih.gov/gene/?term=73162 3110030K17Rik lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021273 7316 UBC http://www.ncbi.nlm.nih.gov/gene/?term=7316 HMG20 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021274 73178 Wasl http://www.ncbi.nlm.nih.gov/gene/?term=73178 "2900021I12Rik, 3110031I02Rik, N-WASP " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021275 7317 UBA1 http://www.ncbi.nlm.nih.gov/gene/?term=7317 "A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2A, UBE1, UBE1X, UBA1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021276 7317 UBA1 http://www.ncbi.nlm.nih.gov/gene/?term=7317 "A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2A, UBE1, UBE1X, UBA1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021277 7317 UBA1 http://www.ncbi.nlm.nih.gov/gene/?term=7317 "A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021278 73186 3110045A19Rik http://www.ncbi.nlm.nih.gov/gene/?term=73186 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021279 7318 UBA7 http://www.ncbi.nlm.nih.gov/gene/?term=7318 "D8, UBA1B, UBE1L, UBE2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021280 73192 Xpot http://www.ncbi.nlm.nih.gov/gene/?term=73192 "1110004L07Rik, 3110065H13Rik, AI452076, C79645, EXPORTIN-T " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021281 7319 UBE2A http://www.ncbi.nlm.nih.gov/gene/?term=7319 "HHR6A, MRXS30, MRXSN, RAD6A, UBC2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021282 7319 UBE2A http://www.ncbi.nlm.nih.gov/gene/?term=7319 "HHR6A, MRXS30, MRXSN, RAD6A, UBC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021283 7320 UBE2B http://www.ncbi.nlm.nih.gov/gene/?term=7320 "E2-17kDa, HHR6B, HR6B, RAD6B, UBC2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021284 7320 UBE2B http://www.ncbi.nlm.nih.gov/gene/?term=7320 "E2-17kDa, HHR6B, HR6B, RAD6B, UBC2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021285 732253 TDRG1 http://www.ncbi.nlm.nih.gov/gene/?term=732253 LINC00532 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021286 7322 UBE2D2 http://www.ncbi.nlm.nih.gov/gene/?term=7322 "E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021287 7322 UBE2D2 http://www.ncbi.nlm.nih.gov/gene/?term=7322 "E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021288 73233 Zfp942 http://www.ncbi.nlm.nih.gov/gene/?term=73233 3110048L19Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021289 73233 Zfp942 http://www.ncbi.nlm.nih.gov/gene/?term=73233 3110048L19Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021290 73238 3110049I03Rik http://www.ncbi.nlm.nih.gov/gene/?term=73238 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021291 7323 UBE2D3 http://www.ncbi.nlm.nih.gov/gene/?term=7323 "E2(17)KB3, UBC4/5, UBCH5C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021292 73255 1700026J12Rik http://www.ncbi.nlm.nih.gov/gene/?term=73255 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021293 73262 1700036O09Rik http://www.ncbi.nlm.nih.gov/gene/?term=73262 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021294 7326 UBE2G1 http://www.ncbi.nlm.nih.gov/gene/?term=7326 "E217K, UBC7, UBE2G " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021295 7326 UBE2G1 http://www.ncbi.nlm.nih.gov/gene/?term=7326 "E217K, UBC7, UBE2G " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021296 7326 UBE2G1 http://www.ncbi.nlm.nih.gov/gene/?term=7326 "E217K, UBC7, UBE2G " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021297 73274 Gpbp1 http://www.ncbi.nlm.nih.gov/gene/?term=73274 "1700034P14Rik, AU019836, D230035M11Rik, Gpbp, mGPBP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021298 73276 1700037J18Rik http://www.ncbi.nlm.nih.gov/gene/?term=73276 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021299 7327 UBE2G2 http://www.ncbi.nlm.nih.gov/gene/?term=7327 UBC7 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021300 7327 UBE2G2 http://www.ncbi.nlm.nih.gov/gene/?term=7327 UBC7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021301 732802 zein http://www.ncbi.nlm.nih.gov/gene/732802 mRNA Zea mays 11910012 Endoplasmic reticulum Endosperm In situ hybridization "We analyzed the distribution of mRNAs encoding the 22-kD alpha-zein and the 27-kD gamma-zein proteins on cisternal and protein body rough endoplasmic reticulum membranes. In situ hybridization revealed similar frequencies of the mRNAs in both regions of the endoplasmic reticulum, indicating that the transcripts are distributed more or less randomly. " RLID00021302 73288 Vps50 http://www.ncbi.nlm.nih.gov/gene/?term=73288 "1700034M03Rik, 8430415E05Rik, BLM, C87205, Ccdc132, mKIAA1861 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021303 7328 UBE2H http://www.ncbi.nlm.nih.gov/gene/?term=7328 "E2-20K, GID3, UBC8, UBCH, UBCH2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021304 7328 UBE2H http://www.ncbi.nlm.nih.gov/gene/?term=7328 "E2-20K, GID3, UBC8, UBCH, UBCH2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021305 7329 UBE2I http://www.ncbi.nlm.nih.gov/gene/?term=7329 "C358B7.1, P18, UBC9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021306 7329 UBE2I http://www.ncbi.nlm.nih.gov/gene/?term=7329 "C358B7.1, P18, UBC9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021307 73310 1700044K19Rik http://www.ncbi.nlm.nih.gov/gene/?term=73310 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021308 7332 UBE2L3 http://www.ncbi.nlm.nih.gov/gene/?term=7332 "E2-F1, L-UBC, UBCH7, UbcM4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021309 7332 UBE2L3 http://www.ncbi.nlm.nih.gov/gene/?term=7332 "E2-F1, L-UBC, UBCH7, UbcM4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021310 7332 UBE2L3 http://www.ncbi.nlm.nih.gov/gene/?term=7332 "E2-F1, L-UBC, UBCH7, UbcM4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021311 7332 UBE2L3 http://www.ncbi.nlm.nih.gov/gene/?term=7332 "E2-F1, L-UBC, UBCH7, UbcM4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021312 7334 UBE2N http://www.ncbi.nlm.nih.gov/gene/?term=7334 "HEL-S-71, UBC13, UBCHBEN, UBC13, UbcH-ben, UbcH13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021313 7334 UBE2N http://www.ncbi.nlm.nih.gov/gene/?term=7334 "HEL-S-71, UBC13, UBCHBEN, UBC13, UbcH-ben, UbcH13 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021314 7334 UBE2N http://www.ncbi.nlm.nih.gov/gene/?term=7334 "HEL-S-71, UBC13, UBCHBEN, UBC13, UbcH-ben, UbcH13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021315 73363 1700056E22Rik http://www.ncbi.nlm.nih.gov/gene/?term=73363 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021316 7336 UBE2V2 http://www.ncbi.nlm.nih.gov/gene/?term=7336 "DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021317 7336 UBE2V2 http://www.ncbi.nlm.nih.gov/gene/?term=7336 "DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021318 7336 UBE2V2 http://www.ncbi.nlm.nih.gov/gene/?term=7336 "DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021319 73373 Phospho2 http://www.ncbi.nlm.nih.gov/gene/?term=73373 "1700048E23Rik, AI661517, AU021728, AV006103, Phos2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021320 73378 1700060L04Rik http://www.ncbi.nlm.nih.gov/gene/?term=73378 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021321 7337 UBE3A http://www.ncbi.nlm.nih.gov/gene/?term=7337 "ANCR, AS, E6-AP, EPVE6AP, HPVE6A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021322 7337 UBE3A http://www.ncbi.nlm.nih.gov/gene/?term=7337 "ANCR, AS, E6-AP, EPVE6AP, HPVE6A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021323 734060 mogat1 http://www.ncbi.nlm.nih.gov/gene/?term=734060 "dgat2l, dgat2l1 " mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00021324 73408 1700065L07Rik http://www.ncbi.nlm.nih.gov/gene/?term=73408 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021325 7341 SUMO1 http://www.ncbi.nlm.nih.gov/gene/?term=7341 "DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021326 7341 SUMO1 http://www.ncbi.nlm.nih.gov/gene/?term=7341 "DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021327 7341 SUMO1 http://www.ncbi.nlm.nih.gov/gene/?term=7341 "DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021328 734240 trib1 http://www.ncbi.nlm.nih.gov/gene/?term=734240 "c8fw, gig2, skip1, trb1, tribbles " mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00021329 73429 Hoxd3os1 http://www.ncbi.nlm.nih.gov/gene/?term=73429 "1700064D17Rik, 1700109F18Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021330 73435 Tex35 http://www.ncbi.nlm.nih.gov/gene/?term=73435 1700057K13Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021331 73437 1700064F23Rik http://www.ncbi.nlm.nih.gov/gene/?term=73437 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021332 7343 UBTF http://www.ncbi.nlm.nih.gov/gene/?term=7343 "NOR-90, UBF, UBF-1, UBF1, UBF2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021333 734470 cpeb1-b http://www.ncbi.nlm.nih.gov/gene/?term=734470 CPEB mRNA Xenopus laevis 11081630 Mitotic spindle Embryo Whole mount In Situ Hybridization "CPEB, Maskin, and Cyclin B1 mRNA at the mitotic apparatus: implications for local translational control of cell division. " RLID00021334 73447 Wdr13 http://www.ncbi.nlm.nih.gov/gene/?term=73447 "1700060B08Rik, 5730411P10Rik, DXHXS7467e, W51679, mMg21 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021335 7345 UCHL1 http://www.ncbi.nlm.nih.gov/gene/?term=7345 "HEL-117, HEL-S-53, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021336 7345 UCHL1 http://www.ncbi.nlm.nih.gov/gene/?term=7345 "HEL-117, HEL-S-53, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021337 73463 Als2cr11 http://www.ncbi.nlm.nih.gov/gene/?term=73463 "1700052H20Rik, 4930408G06Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021338 73473 Iws1 http://www.ncbi.nlm.nih.gov/gene/?term=73473 "1700069O15Rik, 3000008H23, AL117927, AW214353 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021339 7347 UCHL3 http://www.ncbi.nlm.nih.gov/gene/?term=7347 UCH-L3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021340 7347 UCHL3 http://www.ncbi.nlm.nih.gov/gene/?term=7347 UCH-L3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021341 73483 1700074A11Rik http://www.ncbi.nlm.nih.gov/gene/?term=73483 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021342 734998 farp2 http://www.ncbi.nlm.nih.gov/gene/?term=734998 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00021343 734 OSGIN2 http://www.ncbi.nlm.nih.gov/gene/?term=734 "C8orf1, hT41 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021344 7351 UCP2 http://www.ncbi.nlm.nih.gov/gene/?term=7351 "BMIQ4, SLC25A8, UCPH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021345 73526 Speer4b http://www.ncbi.nlm.nih.gov/gene/?term=73526 "1700081O22Rik, SPEER-4B " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021346 735301 SNHG9 http://www.ncbi.nlm.nih.gov/gene/?term=735301 NCRNA00062 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021347 7353 UFD1L http://www.ncbi.nlm.nih.gov/gene/?term=7353 UFD1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021348 7353 UFD1L http://www.ncbi.nlm.nih.gov/gene/?term=7353 UFD1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021349 7353 UFD1L http://www.ncbi.nlm.nih.gov/gene/?term=7353 UFD1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021350 7354404 Yeti http://www.ncbi.nlm.nih.gov/gene/?term=7354404 "Dmel_CG40218, 41Aa, BEST:GH01620, BcDNA:RE36623, CG40218, Dmel\CG40218, GroupI, l(2)41Aa, l(2)EMS31, l(2R)B, l(2R)EMS-31 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00021351 7354465 CG42232 http://www.ncbi.nlm.nih.gov/gene/?term=7354465 "Dmel_ CG14896, CG14897, Dmel\CG42232, Dmel_CG14896, Dmel_CG14897, anon-EST:Liang-1.14, clone 1.14 " mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00021352 73545 1700094D03Rik http://www.ncbi.nlm.nih.gov/gene/?term=73545 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021353 7355 SLC35A2 http://www.ncbi.nlm.nih.gov/gene/?term=7355 "CDG2M, CDGX, UDP-Gal-Tr, UGALT, UGAT, UGT, UGT1, UGT2, UGTL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021354 7355 SLC35A2 http://www.ncbi.nlm.nih.gov/gene/?term=7355 "CDG2M, CDGX, UDP-Gal-Tr, UGALT, UGAT, UGT, UGT1, UGT2, UGTL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021355 73577 1700102F20Rik http://www.ncbi.nlm.nih.gov/gene/?term=73577 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021356 7357 UGCG http://www.ncbi.nlm.nih.gov/gene/?term=7357 "GCS, GLCT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021357 7357 UGCG http://www.ncbi.nlm.nih.gov/gene/?term=7357 "GCS, GLCT1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021358 7357 UGCG http://www.ncbi.nlm.nih.gov/gene/?term=7357 "GCS, GLCT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021359 73582 Camkmt http://www.ncbi.nlm.nih.gov/gene/?term=73582 "1700106N22Rik, AI480743, AV099781, CLNMT, CaM KMT " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021360 73589 1700101I19Rik http://www.ncbi.nlm.nih.gov/gene/?term=73589 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021361 7358 UGDH http://www.ncbi.nlm.nih.gov/gene/?term=7358 "GDH, UDP-GlcDH, UDPGDH, UGD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021362 7358 UGDH http://www.ncbi.nlm.nih.gov/gene/?term=7358 "GDH, UDP-GlcDH, UDPGDH, UGD " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021363 7358 UGDH http://www.ncbi.nlm.nih.gov/gene/?term=7358 "GDH, UDP-GlcDH, UDPGDH, UGD " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021364 73603 Trp53tg5 http://www.ncbi.nlm.nih.gov/gene/?term=73603 1700126L10Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021365 7360 UGP2 http://www.ncbi.nlm.nih.gov/gene/?term=7360 "UDPG, UDPGP, UDPGP2, UGP1, UGPP1, UGPP2, pHC379 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021366 7360 UGP2 http://www.ncbi.nlm.nih.gov/gene/?term=7360 "UDPG, UDPGP, UDPGP2, UGP1, UGPP1, UGPP2, pHC379 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021367 7360 UGP2 http://www.ncbi.nlm.nih.gov/gene/?term=7360 "UDPG, UDPGP, UDPGP2, UGP1, UGPP1, UGPP2, pHC379 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021368 73628 1700125G02Rik http://www.ncbi.nlm.nih.gov/gene/?term=73628 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021369 7364 UGT2B7 http://www.ncbi.nlm.nih.gov/gene/?term=7364 "UDPGT 2B9, UDPGT2B7, UDPGTH2, UGT2B9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021370 73668 Ttc21b http://www.ncbi.nlm.nih.gov/gene/?term=73668 "2410066K11Rik, Thm1, aln, mKIAA1992 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021371 73674 Wdr75 http://www.ncbi.nlm.nih.gov/gene/?term=73674 "1300003A18Rik, 2410118I19Rik, C77608 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021372 73674 Wdr75 http://www.ncbi.nlm.nih.gov/gene/?term=73674 "1300003A18Rik, 2410118I19Rik, C77608 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021373 73680 Zbtb8a http://www.ncbi.nlm.nih.gov/gene/?term=73680 "2410081M15Rik, AI480941 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021374 73681 Trmt11 http://www.ncbi.nlm.nih.gov/gene/?term=73681 "2410075D05Rik, 3110045I18Rik, AW213713 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021375 7368 UGT8 http://www.ncbi.nlm.nih.gov/gene/?term=7368 "CGT, UGT4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021376 7368 UGT8 http://www.ncbi.nlm.nih.gov/gene/?term=7368 "CGT, UGT4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021377 73692 2410089E03Rik http://www.ncbi.nlm.nih.gov/gene/?term=73692 "4732468D17Rik, Hug, Jbts17, b2b012Clo " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021378 7369 UMOD http://www.ncbi.nlm.nih.gov/gene/?term=7369 "ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021379 73708 Dppa3 http://www.ncbi.nlm.nih.gov/gene/?term=73708 "2410075G02Rik, PCG7, PGC7, Stella " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021380 7371 UCK2 http://www.ncbi.nlm.nih.gov/gene/?term=7371 "TSA903, UK, UMPK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021381 7371 UCK2 http://www.ncbi.nlm.nih.gov/gene/?term=7371 "TSA903, UK, UMPK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021382 73724 Mcee http://www.ncbi.nlm.nih.gov/gene/?term=73724 1110007A04Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021383 7372 UMPS http://www.ncbi.nlm.nih.gov/gene/?term=7372 OPRT mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021384 7372 UMPS http://www.ncbi.nlm.nih.gov/gene/?term=7372 OPRT mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021385 7372 UMPS http://www.ncbi.nlm.nih.gov/gene/?term=7372 OPRT mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021386 7372 UMPS http://www.ncbi.nlm.nih.gov/gene/?term=7372 OPRT mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021387 7372 UMPS http://www.ncbi.nlm.nih.gov/gene/?term=7372 OPRT mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021388 73737 1110008P14Rik http://www.ncbi.nlm.nih.gov/gene/?term=73737 C79326 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00021389 73739 Cby1 http://www.ncbi.nlm.nih.gov/gene/?term=73739 "1110014P06Rik, CBY, PGEA14, Pgea1, arb1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021390 7373 COL14A1 http://www.ncbi.nlm.nih.gov/gene/?term=7373 UND mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021391 7373 COL14A1 http://www.ncbi.nlm.nih.gov/gene/?term=7373 UND mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021392 73744 Man2c1 http://www.ncbi.nlm.nih.gov/gene/?term=73744 1110025H24Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021393 73747 1110034G24Rik http://www.ncbi.nlm.nih.gov/gene/?term=73747 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021394 7374 UNG http://www.ncbi.nlm.nih.gov/gene/?term=7374 "DGU, HIGM4, HIGM5, UDG1, UNG15, UNG2, UNG " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021395 7375 USP4 http://www.ncbi.nlm.nih.gov/gene/?term=7375 "UNP, Unph " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021396 7375 USP4 http://www.ncbi.nlm.nih.gov/gene/?term=7375 "UNP, Unph " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021397 73766 4833420D23Rik http://www.ncbi.nlm.nih.gov/gene/?term=73766 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021398 7376 NR1H2 http://www.ncbi.nlm.nih.gov/gene/?term=7376 "LXR-b, LXRB, NER, NER-I, RIP15, UNR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021399 7376 NR1H2 http://www.ncbi.nlm.nih.gov/gene/?term=7376 "LXR-b, LXRB, NER, NER-I, RIP15, UNR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021400 73786 4930429L21Rik http://www.ncbi.nlm.nih.gov/gene/?term=73786 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021401 7378 UPP1 http://www.ncbi.nlm.nih.gov/gene/?term=7378 "UDRPASE, UP, UPASE, UPP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021402 73792 4930401G09Rik http://www.ncbi.nlm.nih.gov/gene/?term=73792 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021403 73794 4930402M22Rik http://www.ncbi.nlm.nih.gov/gene/?term=73794 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021404 73804 Kif2c http://www.ncbi.nlm.nih.gov/gene/?term=73804 "4930402F02Rik, ESTM5, Knsl6, MCAK, X83316 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021405 73817 4930404F17Rik http://www.ncbi.nlm.nih.gov/gene/?term=73817 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021406 7381 UQCRB http://www.ncbi.nlm.nih.gov/gene/?term=7381 "MC3DN3, QCR7, QP-C, QPC, UQBC, UQBP, UQCR6, UQPC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021407 7381 UQCRB http://www.ncbi.nlm.nih.gov/gene/?term=7381 "MC3DN3, QCR7, QP-C, QPC, UQBC, UQBP, UQCR6, UQPC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021408 73824 Snhg6 http://www.ncbi.nlm.nih.gov/gene/?term=73824 1110008H02Rik lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021409 73847 Fam110a http://www.ncbi.nlm.nih.gov/gene/?term=73847 "1700008J10Rik, 5430432M24Rik, AI747080 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021410 7384 UQCRC1 http://www.ncbi.nlm.nih.gov/gene/?term=7384 "D3S3191, QCR1, UQCR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021411 7384 UQCRC1 http://www.ncbi.nlm.nih.gov/gene/?term=7384 "D3S3191, QCR1, UQCR1 " mRNA Homo sapiens 23500070 Mitochondrion SH-SY5Y cell Fluorescence in situ hybridization "These results demonstrate that TMEM126A mRNA is an MLR, with asymmetric localization to the mitochondrial surface similar to UQCRC1 mRNA, which is known to encode a mitochondrial protein of the IM. " RLID00021412 7385 UQCRC2 http://www.ncbi.nlm.nih.gov/gene/?term=7385 "MC3DN5, QCR2, UQCR2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021413 7385 UQCRC2 http://www.ncbi.nlm.nih.gov/gene/?term=7385 "MC3DN5, QCR2, UQCR2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021414 73868 4930415N12Rik http://www.ncbi.nlm.nih.gov/gene/?term=73868 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021415 7386 UQCRFS1 http://www.ncbi.nlm.nih.gov/gene/?term=7386 "RIP1, RIS1, RISP, UQCR5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021416 7386 UQCRFS1 http://www.ncbi.nlm.nih.gov/gene/?term=7386 "RIP1, RIS1, RISP, UQCR5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021417 73884 Zdbf2 http://www.ncbi.nlm.nih.gov/gene/?term=73884 "4930431J08Rik, 9330107J05Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021418 7388 UQCRH http://www.ncbi.nlm.nih.gov/gene/?term=7388 "QCR6, UQCR8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021419 7389 UROD http://www.ncbi.nlm.nih.gov/gene/?term=7389 "PCT, UPD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021420 7389 UROD http://www.ncbi.nlm.nih.gov/gene/?term=7389 "PCT, UPD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021421 7389 UROD http://www.ncbi.nlm.nih.gov/gene/?term=7389 "PCT, UPD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021422 738 VPS51 http://www.ncbi.nlm.nih.gov/gene/?term=738 "ANG2, ANG3, C11orf2, C11orf3, FFR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021423 73902 Psmb11 http://www.ncbi.nlm.nih.gov/gene/?term=73902 "5830406J20Rik, beta5t " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021424 7390 UROS http://www.ncbi.nlm.nih.gov/gene/?term=7390 UROIIIS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021425 7390 UROS http://www.ncbi.nlm.nih.gov/gene/?term=7390 UROIIIS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021426 73916 Ift57 http://www.ncbi.nlm.nih.gov/gene/?term=73916 "4833420A15Rik, Esrrbl1, Hippi, MHS4R2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021427 7391 USF1 http://www.ncbi.nlm.nih.gov/gene/?term=7391 "FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021428 7392 USF2 http://www.ncbi.nlm.nih.gov/gene/?term=7392 "FIP, bHLHb12 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021429 7392 USF2 http://www.ncbi.nlm.nih.gov/gene/?term=7392 "FIP, bHLHb12 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021430 73948 4930415P13Rik http://www.ncbi.nlm.nih.gov/gene/?term=73948 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021431 73966 4930449I21Rik http://www.ncbi.nlm.nih.gov/gene/?term=73966 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021432 73985 4930445N18Rik http://www.ncbi.nlm.nih.gov/gene/?term=73985 3010027C24Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021433 73988 4930438A08Rik http://www.ncbi.nlm.nih.gov/gene/?term=73988 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021434 7398 USP1 http://www.ncbi.nlm.nih.gov/gene/?term=7398 UBP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021435 7398 USP1 http://www.ncbi.nlm.nih.gov/gene/?term=7398 UBP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021436 74006 Dnm1l http://www.ncbi.nlm.nih.gov/gene/?term=74006 "6330417M19Rik, AI450666, Dlp1, Dnmlp1, Drp1, python " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021437 74011 Slc25a27 http://www.ncbi.nlm.nih.gov/gene/?term=74011 "3632410G24Rik, 9430092A03Rik, D530043E16Rik, Ucp4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021438 74012 Rap2b http://www.ncbi.nlm.nih.gov/gene/?term=74012 "4021402C18Rik, AA408554 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021439 74014 3732407C23Rik http://www.ncbi.nlm.nih.gov/gene/?term=74014 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021440 74026 Msl1 http://www.ncbi.nlm.nih.gov/gene/?term=74026 "2810017F12Rik, 4121402D02Rik, 4930463F05Rik, AA682082, Msl-1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021441 7402 UTRN http://www.ncbi.nlm.nih.gov/gene/?term=7402 "DMDL, DRP, DRP1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021442 7402 UTRN http://www.ncbi.nlm.nih.gov/gene/?term=7402 "DMDL, DRP, DRP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021443 7402 UTRN http://www.ncbi.nlm.nih.gov/gene/?term=7402 "DMDL, DRP, DRP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021444 7402 UTRN http://www.ncbi.nlm.nih.gov/gene/?term=7402 "DMDL, DRP, DRP1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021445 7402 UTRN http://www.ncbi.nlm.nih.gov/gene/?term=7402 "DMDL, DRP, DRP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021446 74034 4632404H12Rik http://www.ncbi.nlm.nih.gov/gene/?term=74034 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021447 74034 4632404H12Rik http://www.ncbi.nlm.nih.gov/gene/?term=74034 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021448 7403 KDM6A http://www.ncbi.nlm.nih.gov/gene/?term=7403 "KABUK2, UTX, bA386N14.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021449 74042 4921501E09Rik http://www.ncbi.nlm.nih.gov/gene/?term=74042 PHF8 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021450 74044 Ttf2 http://www.ncbi.nlm.nih.gov/gene/?term=74044 "4632434F22Rik, 8030447N19, AV218430 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021451 74046 4632432E15Rik http://www.ncbi.nlm.nih.gov/gene/?term=74046 Gm38310 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021452 7404 UTY http://www.ncbi.nlm.nih.gov/gene/?term=7404 "KDM6AL1, UTY " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021453 7404 UTY http://www.ncbi.nlm.nih.gov/gene/?term=7404 "KDM6AL1, UTY " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021454 74050 4921525O09Rik http://www.ncbi.nlm.nih.gov/gene/?term=74050 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021455 74053 Grip1 http://www.ncbi.nlm.nih.gov/gene/?term=74053 "4931400F03Rik, GRIP, eb " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021456 74055 Plce1 http://www.ncbi.nlm.nih.gov/gene/?term=74055 "4933403A21Rik, PLCepsilon, Plce, mKIAA1516 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021457 74059 4933406G16Rik http://www.ncbi.nlm.nih.gov/gene/?term=74059 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021458 7405 UVRAG http://www.ncbi.nlm.nih.gov/gene/?term=7405 "DHTX, VPS38, p63 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021459 7405 UVRAG http://www.ncbi.nlm.nih.gov/gene/?term=7405 "DHTX, VPS38, p63 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021460 74061 4933404K08Rik http://www.ncbi.nlm.nih.gov/gene/?term=74061 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021461 74068 Asz1 http://www.ncbi.nlm.nih.gov/gene/?term=74068 "4933400N19Rik, Gasz, ORF3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021462 7407 VARS http://www.ncbi.nlm.nih.gov/gene/?term=7407 "G7A1, VARS2, VARS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021463 7407 VARS http://www.ncbi.nlm.nih.gov/gene/?term=7407 "G7A1, VARS2, VARS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021464 7407 VARS http://www.ncbi.nlm.nih.gov/gene/?term=7407 "G7A, VARS1, VARS2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021465 74081 Cep350 http://www.ncbi.nlm.nih.gov/gene/?term=74081 "4933409L06Rik, 6430546F08Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021466 74081 Cep350 http://www.ncbi.nlm.nih.gov/gene/?term=74081 "4933409L06Rik, 6430546F08Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021467 74085 4933414I06Rik http://www.ncbi.nlm.nih.gov/gene/?term=74085 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021468 74086 4933411D12Rik http://www.ncbi.nlm.nih.gov/gene/?term=74086 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021469 7408 VASP http://www.ncbi.nlm.nih.gov/gene/?term=7408 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021470 7408 VASP http://www.ncbi.nlm.nih.gov/gene/?term=7408 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021471 74096 Hvcn1 http://www.ncbi.nlm.nih.gov/gene/?term=74096 "0610039P13Rik, AI450555, BTS, HV1, Vsop., mVSOP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021472 7409 VAV1 http://www.ncbi.nlm.nih.gov/gene/?term=7409 VAV mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021473 740 MRPL49 http://www.ncbi.nlm.nih.gov/gene/?term=740 "C11orf4, L49mt, MRP-L49, NOF, NOF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021474 740 MRPL49 http://www.ncbi.nlm.nih.gov/gene/?term=740 "C11orf4, L49mt, MRP-L49, NOF, NOF1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021475 740 MRPL49 http://www.ncbi.nlm.nih.gov/gene/?term=740 "C11orf4, L49mt, MRP-L49, NOF, NOF1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021476 74100 Arpp21 http://www.ncbi.nlm.nih.gov/gene/?term=74100 "0710001E13Rik, AI853636, ARPP-21, D9Bwg1012e, R3hdm3, Tarpp " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021477 74102 Slc35a5 http://www.ncbi.nlm.nih.gov/gene/?term=74102 "1010001J06Rik, AU021179, BB097433, D16Ertd450e, D730043G07Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021478 74106 Dcaf6 http://www.ncbi.nlm.nih.gov/gene/?term=74106 "1200006M05Rik, Iqwd1, PC326 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021479 74107 Cep55 http://www.ncbi.nlm.nih.gov/gene/?term=74107 "1200008O12Rik, 2700032M20Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021480 7410 VAV2 http://www.ncbi.nlm.nih.gov/gene/?term=7410 VAV-2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021481 74111 Rbm19 http://www.ncbi.nlm.nih.gov/gene/?term=74111 "1200009A02Rik, AV302714, NPO " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021482 74112 Usp16 http://www.ncbi.nlm.nih.gov/gene/?term=74112 "1200004E02Rik, 2810483I07Rik, 6330514E22Rik, UBPM " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021483 74114 Crot http://www.ncbi.nlm.nih.gov/gene/?term=74114 1200003H03Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021484 74117 Actr3 http://www.ncbi.nlm.nih.gov/gene/?term=74117 "1200003A09Rik, Arp3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021485 7411 VBP1 http://www.ncbi.nlm.nih.gov/gene/?term=7411 "HIBBJ46, PFD3, PFDN3, VBP-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021486 7411 VBP1 http://www.ncbi.nlm.nih.gov/gene/?term=7411 "HIBBJ46, PFD3, PFDN3, VBP-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021487 7411 VBP1 http://www.ncbi.nlm.nih.gov/gene/?term=7411 "HIBBJ46, PFD3, PFDN3, VBP-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021488 74120 Zfp263 http://www.ncbi.nlm.nih.gov/gene/?term=74120 "1200014J04Rik, AI326880, AU020888, NT2, mFPM315 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021489 74123 Foxp4 http://www.ncbi.nlm.nih.gov/gene/?term=74123 "1200010K03Rik, 2310007G05Rik, mFKHLA " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021490 74125 Armc8 http://www.ncbi.nlm.nih.gov/gene/?term=74125 "1200015K23Rik, Gid5, HSPC056 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021491 74132 Rnf6 http://www.ncbi.nlm.nih.gov/gene/?term=74132 "1200013I08Rik, 5730419H05Rik, AA537053 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021492 74143 Opa1 http://www.ncbi.nlm.nih.gov/gene/?term=74143 "1200011N24Rik, AI225888, AI847218, lilr3, mKIAA0567 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021493 7414 VCL http://www.ncbi.nlm.nih.gov/gene/?term=7414 "CMD1W, CMH15, HEL114, MV, MVCL " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021494 7414 VCL http://www.ncbi.nlm.nih.gov/gene/?term=7414 "CMD1W, CMH15, HEL114, MV, MVCL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021495 7414 VCL http://www.ncbi.nlm.nih.gov/gene/?term=7414 "CMD1W, CMH15, HEL114, MV, MVCL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021496 74150 Slc35f5 http://www.ncbi.nlm.nih.gov/gene/?term=74150 "1300003P13Rik, AI646727 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021497 7415 VCP http://www.ncbi.nlm.nih.gov/gene/?term=7415 "ALS14, CMT2Y, HEL-220, HEL-S-70, IBMPFD, IBMPFD1, TERA, p97 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021498 74164 Nfx1 http://www.ncbi.nlm.nih.gov/gene/?term=74164 "1300017N15Rik, 3000003M19Rik, NFX.1, TEG-42, Tex42 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021499 74167 Nudt9 http://www.ncbi.nlm.nih.gov/gene/?term=74167 "1190002C07Rik, ADPR-PPase, AI462474 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021500 7416 VDAC1 http://www.ncbi.nlm.nih.gov/gene/?term=7416 "PORIN, VDAC-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021501 7416 VDAC1 http://www.ncbi.nlm.nih.gov/gene/?term=7416 "PORIN, VDAC-1 " mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00021502 7416 VDAC1 http://www.ncbi.nlm.nih.gov/gene/?term=7416 "PORIN, VDAC-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021503 74173 Rab10os http://www.ncbi.nlm.nih.gov/gene/?term=74173 "1700012B15Rik, 1810036A22Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021504 74173 Rab10os http://www.ncbi.nlm.nih.gov/gene/?term=74173 "1700012B15Rik, 1810036A22Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021505 7417 VDAC2 http://www.ncbi.nlm.nih.gov/gene/?term=7417 POR mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021506 7417 VDAC2 http://www.ncbi.nlm.nih.gov/gene/?term=7417 POR mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021507 74182 Gpcpd1 http://www.ncbi.nlm.nih.gov/gene/?term=74182 "2310004G06Rik, 2310032D16Rik, AU015213, Gde5, Prei4, mKIAA1434 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021508 74185 Gbe1 http://www.ncbi.nlm.nih.gov/gene/?term=74185 "2310045H19Rik, 2810426P10Rik, D16Ertd536e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021509 74187 Katnb1 http://www.ncbi.nlm.nih.gov/gene/?term=74187 "2410003J24Rik, KAT " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021510 74196 Ttc27 http://www.ncbi.nlm.nih.gov/gene/?term=74196 2610511O17Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021511 7419 VDAC3 http://www.ncbi.nlm.nih.gov/gene/?term=7419 "HD-VDAC3, VDAC-3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021512 7419 VDAC3 http://www.ncbi.nlm.nih.gov/gene/?term=7419 "HD-VDAC3, VDAC-3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021513 741 ZNHIT2 http://www.ncbi.nlm.nih.gov/gene/?term=741 "C11orf5, FON " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021514 74203 Eif4enif1 http://www.ncbi.nlm.nih.gov/gene/?term=74203 "2610509L04Rik, A930019J01Rik, AA410001, AU021239, Clast4, D11Ertd166e " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021515 74205 Acsl3 http://www.ncbi.nlm.nih.gov/gene/?term=74205 "2610510B12Rik, Acs3, C85929, Facl3, Pro2194 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021516 7421 VDR http://www.ncbi.nlm.nih.gov/gene/?term=7421 "NR1I1, PPP1R163 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021517 7421 VDR http://www.ncbi.nlm.nih.gov/gene/?term=7421 "NR1I1, PPP1R163 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021518 74222 Sept14 http://www.ncbi.nlm.nih.gov/gene/?term=74222 1700016K13Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021519 7422 VEGFA http://www.ncbi.nlm.nih.gov/gene/?term=7422 "MVCD1, VEGF, VPF " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021520 7422 VEGFA http://www.ncbi.nlm.nih.gov/gene/?term=7422 "MVCD1, VEGF, VPF " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00021521 7422 VEGFA http://www.ncbi.nlm.nih.gov/gene/?term=7422 "MVCD1, VEGF, VPF " mRNA Homo sapiens 25063809 Ribosome HeLa cell qRT-PCR Figure 1: Endoplasmic reticulum-associated mRNAs are partitioned between detergent-resistant and detergent-sensitive membrane domains. Data are collected from Figure 1. RLID00021522 7422 VEGFA http://www.ncbi.nlm.nih.gov/gene/?term=7422 "MVCD1, VEGF, VPF " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00021523 7422 VEGFA http://www.ncbi.nlm.nih.gov/gene/?term=7422 "MVCD1, VEGF, VPF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021524 7422 VEGFA http://www.ncbi.nlm.nih.gov/gene/?term=7422 "VPF, VEGF, MVCD1 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00021525 7423 VEGFB http://www.ncbi.nlm.nih.gov/gene/?term=7423 "VEGFL, VRF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021526 7423 VEGFB http://www.ncbi.nlm.nih.gov/gene/?term=7423 "VEGFL, VRF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021527 74244 Atg7 http://www.ncbi.nlm.nih.gov/gene/?term=74244 "1810013K23Rik, Agp7, Apg7ll, Gm21553, Atg7 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021528 74246 Gale http://www.ncbi.nlm.nih.gov/gene/?term=74246 "2310002A12Rik, AI323962 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021529 74249 Lrrc2 http://www.ncbi.nlm.nih.gov/gene/?term=74249 "2400002D05Rik, 4933431K03Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021530 7424 VEGFC http://www.ncbi.nlm.nih.gov/gene/?term=7424 "Flt4-L, LMPH1D, VRP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021531 7424 VEGFC http://www.ncbi.nlm.nih.gov/gene/?term=7424 "Flt4-L, LMPH1D, VRP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021532 74251 Ankrd9 http://www.ncbi.nlm.nih.gov/gene/?term=74251 2500003O20Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021533 74252 Armc1 http://www.ncbi.nlm.nih.gov/gene/?term=74252 "2310016N05Rik, 2900046P06Rik, 3110009G21Rik, AA409258, AW048872, Arcp, C330014L16Rik " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021534 74256 Cyld http://www.ncbi.nlm.nih.gov/gene/?term=74256 "2010013M14Rik, 2900009M21Rik, C130039D01Rik, CDMT, CYLD1, EAC, mKIAA0849 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00021535 74280 1700084F23Rik http://www.ncbi.nlm.nih.gov/gene/?term=74280 "1700003E18Rik, 4930589D02Rik " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021536 7428 VHL http://www.ncbi.nlm.nih.gov/gene/?term=7428 "HRCA1, RCA11, pVHL, VHL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021537 7428 VHL http://www.ncbi.nlm.nih.gov/gene/?term=7428 "HRCA1, RCA11, pVHL, VHL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021538 7428 VHL http://www.ncbi.nlm.nih.gov/gene/?term=7428 "HRCA1, RCA11, pVHL, VHL " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021539 7428 VHL http://www.ncbi.nlm.nih.gov/gene/?term=7428 "HRCA1, RCA11, pVHL, VHL " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021540 7428 VHL http://www.ncbi.nlm.nih.gov/gene/?term=7428 "HRCA1, RCA1, VHL1, pVHL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021541 74298 1700108I11Rik http://www.ncbi.nlm.nih.gov/gene/?term=74298 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021542 7429 VIL1 http://www.ncbi.nlm.nih.gov/gene/?term=7429 "D2S1471, VIL " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021543 7430 EZR http://www.ncbi.nlm.nih.gov/gene/?term=7430 "CVIL, CVL, HEL-S-105, VIL2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021544 7430 EZR http://www.ncbi.nlm.nih.gov/gene/?term=7430 "CVIL, CVL, HEL-S-105, VIL2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021545 7430 EZR http://www.ncbi.nlm.nih.gov/gene/?term=7430 "CVIL, CVL, HEL-S-105, VIL2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021546 74315 Rnf145 http://www.ncbi.nlm.nih.gov/gene/?term=74315 "3732413I11Rik, TMRF1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021547 7431 VIM http://www.ncbi.nlm.nih.gov/gene/?term=7431 "CTRCT30, HEL113 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021548 7431 VIM http://www.ncbi.nlm.nih.gov/gene/?term=7431 "CTRCT30, HEL113 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021549 74320 Wdr33 http://www.ncbi.nlm.nih.gov/gene/?term=74320 "1110001N06Rik, 2310011G05Rik, 2810021O11Rik, 8430413N20Rik, WDC146 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021550 74325 Cltb http://www.ncbi.nlm.nih.gov/gene/?term=74325 2310046E19Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021551 74326 Hnrnpr http://www.ncbi.nlm.nih.gov/gene/?term=74326 "2610003J05Rik, 2610528B01Rik, Hnrpr " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021552 74330 Dnajc14 http://www.ncbi.nlm.nih.gov/gene/?term=74330 "5730551F12Rik, DNAJ, DRIP78, HDJ3, LIP6 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021553 74333 A330040F15Rik http://www.ncbi.nlm.nih.gov/gene/?term=74333 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021554 74340 Ahcyl2 http://www.ncbi.nlm.nih.gov/gene/?term=74340 "4631427C17Rik, AI227036, Adohcyase3, mKIAA0828 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021555 74347 Tldc1 http://www.ncbi.nlm.nih.gov/gene/?term=74347 "4632415K11Rik, Kiaa1609 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021556 7434 VIPR2 http://www.ncbi.nlm.nih.gov/gene/?term=7434 "C16DUPq36.3, DUP7q36.3, PACAP-R-3, PACAP-R3, VIP-R-2, VPAC2, VPAC2R, VPCAP2R " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021557 7434 VIPR2 http://www.ncbi.nlm.nih.gov/gene/?term=7434 "C16DUPq36.3, DUP7q36.3, PACAP-R-3, PACAP-R3, VIP-R-2, VPAC2, VPAC2R, VPCAP2R " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021558 74355 Smchd1 http://www.ncbi.nlm.nih.gov/gene/?term=74355 "4931400A14Rik, AW554188, MommeD1, mKIAA0650 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021559 74356 4931428F04Rik http://www.ncbi.nlm.nih.gov/gene/?term=74356 "AI426165, Kiaa0895l " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021560 74360 Cep57 http://www.ncbi.nlm.nih.gov/gene/?term=74360 "3110002L15Rik, 4921510P06Rik, 4931428M20Rik, AI467480, Tsp57, mKIAA0092 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021561 7436 VLDLR http://www.ncbi.nlm.nih.gov/gene/?term=7436 "CAMRQ1, CARMQ1, CHRMQ1, VLDL-RCH, VLDLR " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00021562 74388 Dpp8 http://www.ncbi.nlm.nih.gov/gene/?term=74388 "2310004I03Rik, 4932434F09Rik, AI666706, DPP VIII " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021563 74388 Dpp8 http://www.ncbi.nlm.nih.gov/gene/?term=74388 "2310004I03Rik, 4932434F09Rik, AI666706, DPP VIII " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021564 74392 Specc1l http://www.ncbi.nlm.nih.gov/gene/?term=74392 "4930470P14Rik, 4932439K10Rik, 9530057A13Rik, AI317249, Cytsa, mKIAA0376 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021565 74399 Duxf3 http://www.ncbi.nlm.nih.gov/gene/?term=74399 4933403O03Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021566 74401 4933406J08Rik http://www.ncbi.nlm.nih.gov/gene/?term=74401 TERB2 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021567 74410 Ttll11 http://www.ncbi.nlm.nih.gov/gene/?term=74410 "4932702F08Rik, 4933424A20Rik, AU043211, D2Ertd624e " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021568 7442 TRPV1 http://www.ncbi.nlm.nih.gov/gene/?term=7442 VR1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021569 7442 TRPV1 http://www.ncbi.nlm.nih.gov/gene/?term=7442 VR1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021570 74437 4933402E13Rik http://www.ncbi.nlm.nih.gov/gene/?term=74437 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021571 7443 VRK1 http://www.ncbi.nlm.nih.gov/gene/?term=7443 "PCH1, PCH1A " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021572 7443 VRK1 http://www.ncbi.nlm.nih.gov/gene/?term=7443 "PCH1, PCH1A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021573 7443 VRK1 http://www.ncbi.nlm.nih.gov/gene/?term=7443 "PCH1, PCH1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021574 7444 VRK2 http://www.ncbi.nlm.nih.gov/gene/?term=7444 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021575 74451 Pgs1 http://www.ncbi.nlm.nih.gov/gene/?term=74451 "2610019F11Rik, 4933424M23Rik, SAF " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021576 74455 Nsun6 http://www.ncbi.nlm.nih.gov/gene/?term=74455 "4933403D21Rik, 4933414E04Rik, NOPD1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021577 74467 Pus10 http://www.ncbi.nlm.nih.gov/gene/?term=74467 "2810013G11Rik, 4933435A13Rik, AU014648, C77560, Ccdc139 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021578 74474 5230400M06Rik http://www.ncbi.nlm.nih.gov/gene/?term=74474 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021579 74479 Snx11 http://www.ncbi.nlm.nih.gov/gene/?term=74479 "4933439F10Rik, A930041K09Rik, AI117694 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021580 7448 VTN http://www.ncbi.nlm.nih.gov/gene/?term=7448 "V75, VN, VNT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021581 74493 Tnks2 http://www.ncbi.nlm.nih.gov/gene/?term=74493 "5430432P15Rik, AA517131, AI662480, ARTD6, TNKS-2, Tank2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021582 74498 Gorasp1 http://www.ncbi.nlm.nih.gov/gene/?term=74498 "5430411C10Rik, GOLPH5, GRASP65, P65 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021583 74507 5530400K19Rik http://www.ncbi.nlm.nih.gov/gene/?term=74507 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021584 74522 Morc2a http://www.ncbi.nlm.nih.gov/gene/?term=74522 "8430403M08Rik, Zcwcc1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021585 74528 Mgme1 http://www.ncbi.nlm.nih.gov/gene/?term=74528 "8430406I07Rik, AI426476 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021586 74530 9030612E09Rik http://www.ncbi.nlm.nih.gov/gene/?term=74530 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021587 74533 Gzf1 http://www.ncbi.nlm.nih.gov/gene/?term=74533 "8430437G08Rik, Zfp336, mGZF1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021588 74536 9030409C19Rik http://www.ncbi.nlm.nih.gov/gene/?term=74536 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021589 74538 9030409K20Rik http://www.ncbi.nlm.nih.gov/gene/?term=74538 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021590 7453 WARS http://www.ncbi.nlm.nih.gov/gene/?term=7453 "GAMMA-2, IFI53, IFP53 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021591 7453 WARS http://www.ncbi.nlm.nih.gov/gene/?term=7453 "GAMMA-2, IFI53, IFP53 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021592 7453 WARS http://www.ncbi.nlm.nih.gov/gene/?term=7453 "GAMMA-2, IFI53, IFP53 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021593 74545 9030417H13Rik http://www.ncbi.nlm.nih.gov/gene/?term=74545 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021594 7454 WAS http://www.ncbi.nlm.nih.gov/gene/?term=7454 "IMD2, SCNX, THC, THC1, WASP, WASPA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021595 74554 9130002K18Rik http://www.ncbi.nlm.nih.gov/gene/?term=74554 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021596 74561 Nkx6-3 http://www.ncbi.nlm.nih.gov/gene/?term=74561 "9130417I07Rik, Nkx6.3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021597 7456 WIPF1 http://www.ncbi.nlm.nih.gov/gene/?term=7456 "PRPL-2, WAS2, WASPIP, WIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021598 74570 Zkscan1 http://www.ncbi.nlm.nih.gov/gene/?term=74570 "5930429A01Rik, 9130423L19Rik, 9230118B16Rik, AI646829, AI788588, C87323, KOX18, PHZ-37, ZNF139 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021599 74580 Pyroxd2 http://www.ncbi.nlm.nih.gov/gene/?term=74580 "3830409H07Rik, 4833409A17Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021600 74583 4833411I10Rik http://www.ncbi.nlm.nih.gov/gene/?term=74583 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021601 74587 4833422B07Rik http://www.ncbi.nlm.nih.gov/gene/?term=74587 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021602 74587 4833422B07Rik http://www.ncbi.nlm.nih.gov/gene/?term=74587 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021603 7458 EIF4H http://www.ncbi.nlm.nih.gov/gene/?term=7458 "WBSCR1, WSCR1, eIF-4H " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021604 7458 EIF4H http://www.ncbi.nlm.nih.gov/gene/?term=7458 "WBSCR1, WSCR1, eIF-4H " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021605 74600 Mrpl47 http://www.ncbi.nlm.nih.gov/gene/?term=74600 "4833424P18Rik, CGI-204, ENSMUSG00000051761, Gm9859, L47mt, MRP-L47, MTF/L47, NCM1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021606 74601 4833427F10Rik http://www.ncbi.nlm.nih.gov/gene/?term=74601 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021607 7461 CLIP2 http://www.ncbi.nlm.nih.gov/gene/?term=7461 "CLIP, CLIP-115, CYLN2, WBSCR3, WBSCR4, WSCR3, WSCR4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021608 7461 CLIP2 http://www.ncbi.nlm.nih.gov/gene/?term=7461 "CLIP, CLIP-115, CYLN2, WBSCR3, WBSCR4, WSCR3, WSCR4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021609 74658 4930445G23Rik http://www.ncbi.nlm.nih.gov/gene/?term=74658 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021610 7465 WEE1 http://www.ncbi.nlm.nih.gov/gene/?term=7465 "WEE1Ahu, WEE1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021611 74672 4930449A18Rik http://www.ncbi.nlm.nih.gov/gene/?term=74672 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021612 74673 Spdye4a http://www.ncbi.nlm.nih.gov/gene/?term=74673 "4930445A17Rik, 4930451F05Rik, RINGO E4A, Spdy2, Spdye4, Spy/Ringo B, spdyb " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021613 74676 4930456A14Rik http://www.ncbi.nlm.nih.gov/gene/?term=74676 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021614 74682 Wdr35 http://www.ncbi.nlm.nih.gov/gene/?term=74682 "4930459M12Rik, 4931430C06, mKIAA1336 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021615 7468 WHSC1 http://www.ncbi.nlm.nih.gov/gene/?term=7468 "MMSET, NSD2, REIIBP, TRX5, WHS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021616 7468 WHSC1 http://www.ncbi.nlm.nih.gov/gene/?term=7468 "MMSET, NSD2, REIIBP, TRX5, WHS " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021617 7468 WHSC1 http://www.ncbi.nlm.nih.gov/gene/?term=7468 "MMSET, NSD2, REIIBP, TRX5, WHS " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021618 7468 WHSC1 http://www.ncbi.nlm.nih.gov/gene/?term=7468 "MMSET, NSD2, REIIBP, TRX5, WHS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021619 74693 4930509J09Rik http://www.ncbi.nlm.nih.gov/gene/?term=74693 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021620 746 TMEM258 http://www.ncbi.nlm.nih.gov/gene/?term=746 C11orf10 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021621 746 TMEM258 http://www.ncbi.nlm.nih.gov/gene/?term=746 C11orf10 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021622 74704 4930518I15Rik http://www.ncbi.nlm.nih.gov/gene/?term=74704 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021623 74707 4930521G14Rik http://www.ncbi.nlm.nih.gov/gene/?term=74707 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021624 74718 Snx16 http://www.ncbi.nlm.nih.gov/gene/?term=74718 "4930522N22Rik, AI117577, AI747675 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021625 74730 5830413G11Rik http://www.ncbi.nlm.nih.gov/gene/?term=74730 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021626 74737 Pcf11 http://www.ncbi.nlm.nih.gov/gene/?term=74737 "2500001H09Rik, 5730417B17Rik, C77803 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021627 74741 C2cd5 http://www.ncbi.nlm.nih.gov/gene/?term=74741 "5730419I09Rik, C030008B15Rik, CDP138 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021628 7474 WNT5A http://www.ncbi.nlm.nih.gov/gene/?term=7474 hWNT5A mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021629 74753 Trmo http://www.ncbi.nlm.nih.gov/gene/?term=74753 "5830415F09Rik, AV014846, Nap1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021630 74764 Klc4 http://www.ncbi.nlm.nih.gov/gene/?term=74764 "1200014P03Rik, AA408085, AW146303, Knsl8 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021631 74778 Rrp7a http://www.ncbi.nlm.nih.gov/gene/?term=74778 "1110014J01Rik, AA408146, Kheg1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021632 747 DAGLA http://www.ncbi.nlm.nih.gov/gene/?term=747 "C11orf11, DAGL(ALPHA), DAGLALPHA, NSDDR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021633 7481 WNT11 http://www.ncbi.nlm.nih.gov/gene/?term=7481 HWNT11 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021634 74838 Naa15 http://www.ncbi.nlm.nih.gov/gene/?term=74838 "5730450D16Rik, 6330400I15, ASTBDN, Narg1, Tbdn-1, mNAT1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021635 74841 Usp38 http://www.ncbi.nlm.nih.gov/gene/?term=74841 "4631402N15Rik, 4833420O05Rik, AA536967, AU044701, AW544820, mKIAA1891 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021636 74857 4930448O17Rik http://www.ncbi.nlm.nih.gov/gene/?term=74857 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021637 7485 WRB http://www.ncbi.nlm.nih.gov/gene/?term=7485 "CHD5, GET1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021638 7485 WRB http://www.ncbi.nlm.nih.gov/gene/?term=7485 "CHD5, GET1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021639 74867 4930445B03Rik http://www.ncbi.nlm.nih.gov/gene/?term=74867 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021640 74869 4930447G04Rik http://www.ncbi.nlm.nih.gov/gene/?term=74869 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021641 7486 WRN http://www.ncbi.nlm.nih.gov/gene/?term=7486 "RECQ3, RECQL2, RECQL3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021642 74873 4930443G03Rik http://www.ncbi.nlm.nih.gov/gene/?term=74873 Gm44273 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021643 74886 4930445K14Rik http://www.ncbi.nlm.nih.gov/gene/?term=74886 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021644 74896 4930405A10Rik http://www.ncbi.nlm.nih.gov/gene/?term=74896 4930456G20Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021645 7490 WT1 http://www.ncbi.nlm.nih.gov/gene/?term=7490 "AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021646 74914 Cylc2 http://www.ncbi.nlm.nih.gov/gene/?term=74914 4930488P18Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021647 74936 4930474B08Rik http://www.ncbi.nlm.nih.gov/gene/?term=74936 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021648 7494 XBP1 http://www.ncbi.nlm.nih.gov/gene/?term=7494 "TREB-5, TREB5, XBP-1, XBP2 " mRNA Homo sapiens 26068456 Nucleus MCF-7|293T|T47D |3T3 cell RT-PCR "Our results reveal the presence of basal unconventional splicing of XBP1 mRNA in the nucleus that also requires inositol-requiring transmembrane kinase and endonuclease 1a (IRE1a) and can occur independently of acute ER stress. Furthermore, we confirm that acute ER stress induces the splicing of XBP1 mRNA predominantly occurring in the cytoplasm, but it also promotes the splicing in the nucleus. " RLID00021649 7494 XBP1 http://www.ncbi.nlm.nih.gov/gene/?term=7494 "TREB-5, TREB5, XBP-1, XBP2 " mRNA Homo sapiens 26068456 Cytoplasm MCF-7|293T|T47D |3T3 cell RT-PCR "Our results reveal the presence of basal unconventional splicing of XBP1 mRNA in the nucleus that also requires inositol-requiring transmembrane kinase and endonuclease 1a (IRE1a) and can occur independently of acute ER stress. Furthermore, we confirm that acute ER stress induces the splicing of XBP1 mRNA predominantly occurring in the cytoplasm, but it also promotes the splicing in the nucleus. " RLID00021650 7494 XBP1 http://www.ncbi.nlm.nih.gov/gene/?term=7494 "TREB-5, TREB5, XBP-1, XBP2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021651 74957 4930486N12Rik http://www.ncbi.nlm.nih.gov/gene/?term=74957 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021652 74972 4930500A05Rik http://www.ncbi.nlm.nih.gov/gene/?term=74972 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021653 74978 Lrriq1 http://www.ncbi.nlm.nih.gov/gene/?term=74978 "4930503E15Rik, Gm1557 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021654 74996 Usp47 http://www.ncbi.nlm.nih.gov/gene/?term=74996 "4930502N04Rik, A630020C16Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021655 75004 4930467D19Rik http://www.ncbi.nlm.nih.gov/gene/?term=75004 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021656 75036 4930488B01Rik http://www.ncbi.nlm.nih.gov/gene/?term=75036 "AI844408, R74771 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021657 7503 XIST http://www.ncbi.nlm.nih.gov/gene/?term=7503 "DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 " lncRNA Homo sapiens 11440993 Nucleus Embryonic stem cell In situ hybridization|RT-PCR These results identify for the first time a dual function for Tsix as both a repressor of the steady-state level of Xist expression and as a regulator of the distribution of Xist RNA within the nucleus. RLID00021658 7503 XIST http://www.ncbi.nlm.nih.gov/gene/?term=7503 "DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 " lncRNA Homo sapiens 12900550 Nucleus Somatic cell In situ hybridization|RT-PCR "XIST transcripts remain in the nucleus, and their specific localization to the inactive X is important for silencing; however, it is not known how these transcripts localize to the inactive X chromosome. " RLID00021659 7503 XIST http://www.ncbi.nlm.nih.gov/gene/?term=7503 "DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 " lncRNA Homo sapiens 1423611 Nucleus Lymphoblast|Fibroblast In situ hybridization "Consistent with this, fluorescence in situ hybridization experiments demonstrate localization of XIST RNA within the nucleus to a position indistinguishable from the X inactivation-associated Barr body. " RLID00021660 7503 XIST http://www.ncbi.nlm.nih.gov/gene/?term=7503 "DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 " lncRNA Homo sapiens 16682630 Nucleus Fibroblast In situ hybridization "We have shown that XIST RNA remains in the nucleus, functionally associated with the inactive chromatin, forming an interphase territory coincident with Xi. " RLID00021661 7503 XIST http://www.ncbi.nlm.nih.gov/gene/?term=7503 "DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 " lncRNA Homo sapiens 17146760 Nucleus Breast|Ovarian cancer cell In situ hybridization|qRT-PCR "Recently, it was reported that BRCA1 supports localization of XIST RNA to the inactive X chromosome (Xi) in women. " RLID00021662 7503 XIST http://www.ncbi.nlm.nih.gov/gene/?term=7503 "DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 " lncRNA Homo sapiens 25332394 Nucleus - lncRNAdb Data are collected from lncRNAdb database: http://www.lncrnadb.org/xist/ RLID00021663 7503 XIST http://www.ncbi.nlm.nih.gov/gene/?term=7503 "DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 " lncRNA Homo sapiens 19571010 Nucleus HFF|HLF|HeLa cell Fluorescence in situ hybridization "Figure 3b: Subcellular localization analysis of lincRNAs by RNA FISH demonstrates localization of lincRNAs to the nucleus. Each panel represents the in situ hybridization of �0 fluorescently labeled DNA oligos with complementarity to the interrogated lincRNA. RNA FISH experiments were performed in male hFF for each represented lincRNA (XIST, HOTAIR, TUG-1, lincMKLN-1, lincFOXF1, and lincSFPQ), and also in female hLF for XIST (XX). White “speckles�indicate the subcellular localization of each lincRNA. The nuclear compartment is demarked by DAPI staining (purple). " RLID00021664 7503 XIST http://www.ncbi.nlm.nih.gov/gene/?term=7503 "DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 " lncRNA Homo sapiens 8636206 Nucleus Epithelial line In situ hybridization The continually transcribed XIST gene and its polyadenylated RNA consistently localize to a nuclear region devoid of splicing factor/poly A RNA rich domains. RLID00021665 7503 XIST http://www.ncbi.nlm.nih.gov/gene/?term=7503 "DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 " lncRNA Homo sapiens 9560241 Nucleus 4F5 cell RT-PCR We isolated RNA from nuclear and cytoplasmic extracts and found by RT-PCR that the spliced XIST RNA was localized properly to the nuclear fraction in the 4F5 cells (Fi.4). RLID00021666 7503 XIST http://www.ncbi.nlm.nih.gov/gene/?term=7503 "DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 " lncRNA Homo sapiens 25690653 Nucleus P493-6 cell qRT-PCR "To validate the isolation of nuclear and cytoplasmic fractions, the enrichment of 3 nuclear (ANRIL, MIAT, XIST) and 3 cytoplasmic (RPPH1, DANCR, tRNA-Lys) RNAs was analyzed by qRT-PCR. " RLID00021667 7503 XIST http://www.ncbi.nlm.nih.gov/gene/?term=7503 "DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 " lncRNA Homo sapiens 22955988 Nucleus Brain Microarray "We examined the subcellular location of a number of well-known lncRNAs (Fig. 8D). Unsurprisingly, the X-chromosome inactivating transcript XIST was extremely highly enriched in the nucleus for all cells we examined (with a maximum enrichment of 273-fold in the nucleus of GM12878 cells) (Fig. 8D). Other regulatory lncRNAs such as GAS5, LINC00568 (also known as ncRNA-a1), CYP4A22-AS1 (also known as ncRNA-a3), MIAT, and MEG3 were nuclear enriched in at least two different cell types, consistent with their reported roles in gene regulation. Other transcripts, including the bifunctional transcript SRA1, which acts as both a regulatory RNA and a protein-coding sequence, have more variable subcellular location depending on cell type. As reported previously, the H19 transcript is consistently enriched in the cytoplasm, especially when comparing with the chromatin fraction (cytoplasmic/chromatin enrichment 167-fold). " RLID00021668 7504 XK http://www.ncbi.nlm.nih.gov/gene/?term=7504 "KX, MCLDS, NA, NAC, X1k, XKR1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021669 75052 4930509B17Rik http://www.ncbi.nlm.nih.gov/gene/?term=75052 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021670 75062 Sf3a3 http://www.ncbi.nlm.nih.gov/gene/?term=75062 "4930512K19Rik, 60kDa " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021671 75068 4930513N24Rik http://www.ncbi.nlm.nih.gov/gene/?term=75068 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021672 7507 XPA http://www.ncbi.nlm.nih.gov/gene/?term=7507 "XP1, XPAC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021673 75083 Usp50 http://www.ncbi.nlm.nih.gov/gene/?term=75083 "1700086G18Rik, 4930511O11Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021674 75086 4930520P13Rik http://www.ncbi.nlm.nih.gov/gene/?term=75086 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021675 7508 XPC http://www.ncbi.nlm.nih.gov/gene/?term=7508 "RAD4, XP3, XPCC, p125 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021676 75103 4930518I17Rik http://www.ncbi.nlm.nih.gov/gene/?term=75103 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021677 751071 METTL12 http://www.ncbi.nlm.nih.gov/gene/?term=751071 U99HG mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021678 75108 4930513N20Rik http://www.ncbi.nlm.nih.gov/gene/?term=75108 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021679 7511 XPNPEP1 http://www.ncbi.nlm.nih.gov/gene/?term=7511 "APP1, SAMP, XPNPEP, XPNPEPL, XPNPEPL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021680 7511 XPNPEP1 http://www.ncbi.nlm.nih.gov/gene/?term=7511 "APP1, SAMP, XPNPEP, XPNPEPL, XPNPEPL1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021681 7511 XPNPEP1 http://www.ncbi.nlm.nih.gov/gene/?term=7511 "APP1, SAMP, XPNPEP, XPNPEPL, XPNPEPL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021682 75137 Rprd2 http://www.ncbi.nlm.nih.gov/gene/?term=75137 "2810036A19Rik, 4930535B03Rik, 6720469I21Rik, AL022841, AL022940, AU021304, BB077382, mKIAA0460 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021683 75139 Gm38397 http://www.ncbi.nlm.nih.gov/gene/?term=75139 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021684 7514 XPO1 http://www.ncbi.nlm.nih.gov/gene/?term=7514 "CRM1, emb, exp1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021685 7514 XPO1 http://www.ncbi.nlm.nih.gov/gene/?term=7514 "CRM1, emb, exp1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021686 7514 XPO1 http://www.ncbi.nlm.nih.gov/gene/?term=7514 "CRM1, emb, exp1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021687 75154 4930542M03Rik http://www.ncbi.nlm.nih.gov/gene/?term=75154 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021688 75155 4930529K09Rik http://www.ncbi.nlm.nih.gov/gene/?term=75155 4930507G21Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021689 7515 XRCC1 http://www.ncbi.nlm.nih.gov/gene/?term=7515 RCC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021690 7516 XRCC2 http://www.ncbi.nlm.nih.gov/gene/?term=7516 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021691 7516 XRCC2 http://www.ncbi.nlm.nih.gov/gene/?term=7516 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021692 7516 XRCC2 http://www.ncbi.nlm.nih.gov/gene/?term=7516 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021693 7517 XRCC3 http://www.ncbi.nlm.nih.gov/gene/?term=7517 CMM6 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021694 751865 Sap25 http://www.ncbi.nlm.nih.gov/gene/?term=751865 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021695 75188 1700009J07Rik http://www.ncbi.nlm.nih.gov/gene/?term=75188 4930535B06Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021696 7518 XRCC4 http://www.ncbi.nlm.nih.gov/gene/?term=7518 SSMED mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021697 75194 4930527A07Rik http://www.ncbi.nlm.nih.gov/gene/?term=75194 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021698 75203 4930539N22Rik http://www.ncbi.nlm.nih.gov/gene/?term=75203 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021699 75204 Orly http://www.ncbi.nlm.nih.gov/gene/?term=75204 "4930529H12Rik, 4933412F11Rik, Asty(rec) " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021700 7520 XRCC5 http://www.ncbi.nlm.nih.gov/gene/?term=7520 "KARP-1, KARP1, KU80, KUB2, Ku86, NFIV " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021701 7520 XRCC5 http://www.ncbi.nlm.nih.gov/gene/?term=7520 "KARP-1, KARP1, KU80, KUB2, Ku86, NFIV " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021702 75210 Prr3 http://www.ncbi.nlm.nih.gov/gene/?term=75210 "4930540G07Rik, Cat56 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021703 75211 4930542D17Rik http://www.ncbi.nlm.nih.gov/gene/?term=75211 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021704 75220 4930535I16Rik http://www.ncbi.nlm.nih.gov/gene/?term=75220 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021705 75221 Dpp3 http://www.ncbi.nlm.nih.gov/gene/?term=75221 "4930533O14Rik, C86324 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021706 75252 4930555G21Rik http://www.ncbi.nlm.nih.gov/gene/?term=75252 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021707 7525 YES1 http://www.ncbi.nlm.nih.gov/gene/?term=7525 "HsT441, P61-YES, Yes, c-yes " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021708 7525 YES1 http://www.ncbi.nlm.nih.gov/gene/?term=7525 "HsT441, P61-YES, Yes, c-yes " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021709 7525 YES1 http://www.ncbi.nlm.nih.gov/gene/?term=7525 "HsT441, P61-YES, Yes, c-yes " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021710 7525 YES1 http://www.ncbi.nlm.nih.gov/gene/?term=7525 "HsT441, P61-YES, Yes, c-yes " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021711 75269 4930564D02Rik http://www.ncbi.nlm.nih.gov/gene/?term=75269 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021712 75275 Tmco5b http://www.ncbi.nlm.nih.gov/gene/?term=75275 4930563P21Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021713 75284 Bcdin3d http://www.ncbi.nlm.nih.gov/gene/?term=75284 "4930556P03Rik, AV138748 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021714 7528 YY1 http://www.ncbi.nlm.nih.gov/gene/?term=7528 "DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021715 7528 YY1 http://www.ncbi.nlm.nih.gov/gene/?term=7528 "DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021716 7528 YY1 http://www.ncbi.nlm.nih.gov/gene/?term=7528 "DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021717 7529 YWHAB http://www.ncbi.nlm.nih.gov/gene/?term=7529 "GW128, HEL-S-1, HS1, KCIP-1, YWHAA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021718 75302 Asxl2 http://www.ncbi.nlm.nih.gov/gene/?term=75302 "4930556B16Rik, mKIAA1685 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021719 75304 4930563E22Rik http://www.ncbi.nlm.nih.gov/gene/?term=75304 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021720 75305 Ankrd53 http://www.ncbi.nlm.nih.gov/gene/?term=75305 4930564N15Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021721 75316 Taf1d http://www.ncbi.nlm.nih.gov/gene/?term=75316 "2810003M17Rik, 4930553M18Rik, 5930426I11Rik, Josd3, TAF(I)41, TAFI41 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021722 7531 YWHAE http://www.ncbi.nlm.nih.gov/gene/?term=7531 "14-3-3E, HEL2, KCIP-1, MDCR, MDS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021723 7531 YWHAE http://www.ncbi.nlm.nih.gov/gene/?term=7531 "14-3-3E, HEL2, KCIP-1, MDCR, MDS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021724 7531 YWHAE http://www.ncbi.nlm.nih.gov/gene/?term=7531 "14-3-3E, HEL2, KCIP-1, MDCR, MDS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021725 75320 Etnk1 http://www.ncbi.nlm.nih.gov/gene/?term=75320 "1110061E11Rik, 4930555L11Rik, AI195356, AI841245, C80956, D6Ertd3e, EKI1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021726 75326 4930563J15Rik http://www.ncbi.nlm.nih.gov/gene/?term=75326 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021727 7532 YWHAG http://www.ncbi.nlm.nih.gov/gene/?term=7532 "14-3-3GAMMA, PPP1R170 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021728 7532 YWHAG http://www.ncbi.nlm.nih.gov/gene/?term=7532 "14-3-3GAMMA, PPP1R170 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021729 7532 YWHAG http://www.ncbi.nlm.nih.gov/gene/?term=7532 "14-3-3GAMMA, PPP1R170 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021730 75335 4930549O18Rik http://www.ncbi.nlm.nih.gov/gene/?term=75335 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021731 75339 Mphosph8 http://www.ncbi.nlm.nih.gov/gene/?term=75339 "1500035L22Rik, 4930548G07Rik, AU040635 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021732 7533 YWHAH http://www.ncbi.nlm.nih.gov/gene/?term=7533 YWHA1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021733 7533 YWHAH http://www.ncbi.nlm.nih.gov/gene/?term=7533 YWHA1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021734 7533 YWHAH http://www.ncbi.nlm.nih.gov/gene/?term=7533 YWHA1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021735 75349 4930556J02Rik http://www.ncbi.nlm.nih.gov/gene/?term=75349 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021736 7534 YWHAZ http://www.ncbi.nlm.nih.gov/gene/?term=7534 "14-3-3-zeta, HEL-S-3, HEL-S-93, HEL4, KCIP-1, YWHAD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021737 7534 YWHAZ http://www.ncbi.nlm.nih.gov/gene/?term=7534 "14-3-3-zeta, HEL-S-3, HEL-S-93, HEL4, KCIP-1, YWHAD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021738 7534 YWHAZ http://www.ncbi.nlm.nih.gov/gene/?term=7534 "14-3-3-zeta, HEL-S-3, HEL-S-93, HEL4, KCIP-1, YWHAD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021739 75364 4930549P19Rik http://www.ncbi.nlm.nih.gov/gene/?term=75364 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021740 7536 SF1 http://www.ncbi.nlm.nih.gov/gene/?term=7536 "BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021741 7536 SF1 http://www.ncbi.nlm.nih.gov/gene/?term=7536 "BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021742 75373 4930597O21Rik http://www.ncbi.nlm.nih.gov/gene/?term=75373 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021743 75387 Sirt4 http://www.ncbi.nlm.nih.gov/gene/?term=75387 4930596O17Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021744 75410 Kmt2b http://www.ncbi.nlm.nih.gov/gene/?term=75410 "2610014H22Rik, Mll2, Wbp7, mKIAA0304 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021745 75415 Arhgap12 http://www.ncbi.nlm.nih.gov/gene/?term=75415 2810011M08Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021746 75416 Nop14 http://www.ncbi.nlm.nih.gov/gene/?term=75416 "2610033H07Rik, Nol14 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021747 7541 ZBTB14 http://www.ncbi.nlm.nih.gov/gene/?term=7541 "ZF5, ZFP-161, ZFP-5, ZFP161, ZNF478 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021748 75420 Secisbp2 http://www.ncbi.nlm.nih.gov/gene/?term=75420 "2210413N07Rik, 2810012K13Rik, SBP2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021749 75424 Zfp820 http://www.ncbi.nlm.nih.gov/gene/?term=75424 2610036F08Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021750 7542 ZFPL1 http://www.ncbi.nlm.nih.gov/gene/?term=7542 "D11S750, MCG4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021751 75437 1700006E09Rik http://www.ncbi.nlm.nih.gov/gene/?term=75437 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021752 7543 ZFX http://www.ncbi.nlm.nih.gov/gene/?term=7543 ZNF926 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021753 75452 Ascc2 http://www.ncbi.nlm.nih.gov/gene/?term=75452 "1700011I11Rik, 2610034L15Rik, AI482016, ASC1p100, AW046480 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021754 75458 Cklf http://www.ncbi.nlm.nih.gov/gene/?term=75458 "1700001C14Rik, 1810018M11Rik, C32, CKLF1, CKLF3, CKLF4, CKLF52, Cklf6, HSPC224, UCK-1, Cklf " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021755 7546 ZIC2 http://www.ncbi.nlm.nih.gov/gene/?term=7546 HPE5 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021756 754 PTTG1IP http://www.ncbi.nlm.nih.gov/gene/?term=754 "C21orf1, C21orf3, PBF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021757 754 PTTG1IP http://www.ncbi.nlm.nih.gov/gene/?term=754 "C21orf1, C21orf3, PBF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021758 75514 1700013H16Rik http://www.ncbi.nlm.nih.gov/gene/?term=75514 "Slx2, Xlr6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021759 7551 ZNF3 http://www.ncbi.nlm.nih.gov/gene/?term=7551 "A8-51, HF.12, KOX25, PP838, Zfp113 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021760 7551 ZNF3 http://www.ncbi.nlm.nih.gov/gene/?term=7551 "A8-51, HF.12, KOX25, PP838, Zfp113 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021761 75530 Lyrm7 http://www.ncbi.nlm.nih.gov/gene/?term=75530 "1700024C24Rik, 9330147L21Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021762 75547 Akap13 http://www.ncbi.nlm.nih.gov/gene/?term=75547 "1700026G02Rik, 5730522G15Rik, 5830460E08Rik, AKAP-Lbc, BRX, Ht31, LBC, PROTO-LB, PROTO-LBC " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021763 7555 CNBP http://www.ncbi.nlm.nih.gov/gene/?term=7555 "CNBP1, DM2, PROMM, RNF163, ZCCHC22, ZNF9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021764 7555 CNBP http://www.ncbi.nlm.nih.gov/gene/?term=7555 "CNBP1, DM2, PROMM, RNF163, ZCCHC22, ZNF9 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021765 7555 CNBP http://www.ncbi.nlm.nih.gov/gene/?term=7555 "CNBP1, DM2, PROMM, RNF163, ZCCHC22, ZNF9 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021766 7555 CNBP http://www.ncbi.nlm.nih.gov/gene/?term=7555 "CNBP1, DM2, PROMM, RNF163, ZCCHC22, ZNF9 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021767 7555 CNBP http://www.ncbi.nlm.nih.gov/gene/?term=7555 "CNBP1, DM2, PROMM, RNF163, ZCCHC22, ZNF9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021768 75560 Ep400 http://www.ncbi.nlm.nih.gov/gene/?term=75560 "1700020J09Rik, AU023439, mDomino, mKIAA1498, p400 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021769 75565 Sgf29 http://www.ncbi.nlm.nih.gov/gene/?term=75565 "1700023O11Rik, 9530025I05Rik, Ccdc101 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021770 75580 Zbtb4 http://www.ncbi.nlm.nih.gov/gene/?term=75580 "2310026P19Rik, 9230111I22Rik, mKIAA1538 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021771 75596 Prl7b1 http://www.ncbi.nlm.nih.gov/gene/?term=75596 "1600014J19Rik, Ghd17, PLP-N, Prlpn " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021772 7559 ZNF12 http://www.ncbi.nlm.nih.gov/gene/?term=7559 "GIOT-3, HZF11, KOX3, ZNF325 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021773 75604 Tm4sf5 http://www.ncbi.nlm.nih.gov/gene/?term=75604 "2010003F10Rik, AI323987 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021774 75607 Wnk2 http://www.ncbi.nlm.nih.gov/gene/?term=75607 "1810073P09Rik, AW122246, ESTM15, X83337, mKIAA1760 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021775 75612 Gns http://www.ncbi.nlm.nih.gov/gene/?term=75612 "2610016K11Rik, AU042285, C87209, G6S, N28088 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021776 75613 Med25 http://www.ncbi.nlm.nih.gov/gene/?term=75613 "2610034E13Rik, 2610529E18Rik, ESTM2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021777 75614 Rab26os http://www.ncbi.nlm.nih.gov/gene/?term=75614 2610019E17Rik lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021778 75616 Smim15 http://www.ncbi.nlm.nih.gov/gene/?term=75616 2810008M24Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021779 75617 Rps25 http://www.ncbi.nlm.nih.gov/gene/?term=75617 2810009D21Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021780 75617 Rps25 http://www.ncbi.nlm.nih.gov/gene/?term=75617 2810009D21Rik mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00021781 75619 Fastkd2 http://www.ncbi.nlm.nih.gov/gene/?term=75619 2810421I24Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021782 7561 ZNF14 http://www.ncbi.nlm.nih.gov/gene/?term=7561 "GIOT-4, KOX6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021783 75620 Kxd1 http://www.ncbi.nlm.nih.gov/gene/?term=75620 "0610030B01Rik, 2810422J05Rik, C78305 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021784 75627 Snapc1 http://www.ncbi.nlm.nih.gov/gene/?term=75627 "2700033G17Rik, AU015787 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021785 7562 ZNF708 http://www.ncbi.nlm.nih.gov/gene/?term=7562 "KOX8, ZNF15, ZNF15L1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021786 7562 ZNF708 http://www.ncbi.nlm.nih.gov/gene/?term=7562 "KOX8, ZNF15, ZNF15L1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021787 75638 1700008O09Rik http://www.ncbi.nlm.nih.gov/gene/?term=75638 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021788 75646 Rai14 http://www.ncbi.nlm.nih.gov/gene/?term=75646 "1700008J19Rik, 1700020L11Rik, Ankycorbin, Norpeg, mKIAA1334 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021789 75657 Speer4a http://www.ncbi.nlm.nih.gov/gene/?term=75657 "1700027N01Rik, SPEER-4A " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021790 75659 Wdr54 http://www.ncbi.nlm.nih.gov/gene/?term=75659 1700030E05Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021791 75660 Lin37 http://www.ncbi.nlm.nih.gov/gene/?term=75660 1810054G18Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021792 75669 Pik3r4 http://www.ncbi.nlm.nih.gov/gene/?term=75669 "2210010O15Rik, C730038E05Rik, C85833, D9Ertd418e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021793 7566 ZNF18 http://www.ncbi.nlm.nih.gov/gene/?term=7566 "HDSG1, KOX11, ZKSCAN6, ZNF535, ZSCAN38, Zfp535 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021794 7566 ZNF18 http://www.ncbi.nlm.nih.gov/gene/?term=7566 "HDSG1, KOX11, ZKSCAN6, ZNF535, ZSCAN38, Zfp535 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021795 75677 Cldn22 http://www.ncbi.nlm.nih.gov/gene/?term=75677 "2210404A22Rik, 5330431C14Rik, 9530051B05Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021796 75692 Nr2c2ap http://www.ncbi.nlm.nih.gov/gene/?term=75692 2310073E15Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021797 7569 ZNF182 http://www.ncbi.nlm.nih.gov/gene/?term=7569 "HHZ150, KOX14, ZNF21, Zfp182 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021798 75706 Krt24 http://www.ncbi.nlm.nih.gov/gene/?term=75706 "2310058N18Rik, 2310075C18Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021799 75717 Cul5 http://www.ncbi.nlm.nih.gov/gene/?term=75717 "4921514I20Rik, 8430423K24Rik, AI852817, C030032G03Rik, C330021I08Rik, VACM-1, VACM1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021800 7571 ZNF23 http://www.ncbi.nlm.nih.gov/gene/?term=7571 "KOX16, ZNF359, ZNF612, Zfp612 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021801 75725 Phf14 http://www.ncbi.nlm.nih.gov/gene/?term=75725 "1110001C23Rik, 4932409F11Rik, 5730446A07Rik, AA623952, AV297001, mKIAA0783 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021802 7572 ZNF24 http://www.ncbi.nlm.nih.gov/gene/?term=7572 "KOX17, RSG-A, ZNF191, ZSCAN3, Zfp191 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021803 7572 ZNF24 http://www.ncbi.nlm.nih.gov/gene/?term=7572 "KOX17, RSG-A, ZNF191, ZSCAN3, Zfp191 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021804 75731 Idnk http://www.ncbi.nlm.nih.gov/gene/?term=75731 5133401N09Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021805 75734 Mff http://www.ncbi.nlm.nih.gov/gene/?term=75734 "5230400G24Rik, AI314724 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021806 75736 Bcl2l12 http://www.ncbi.nlm.nih.gov/gene/?term=75736 "2810475P17Rik, 5430429M05Rik, Bcl-L12, Bcl2-L12 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021807 75745 Rian http://www.ncbi.nlm.nih.gov/gene/?term=75745 "5530401N18Rik, C130089L09Rik, Meg8 " lncRNA Mus musculus 11481034 Nucleus Embryos cell In situ hybridization|RT-PCR "The Rian transcript did not have any apparent open reading frame, and its transcript was exclusively localized to the nucleus. " RLID00021808 75745 Rian http://www.ncbi.nlm.nih.gov/gene/?term=75745 "5530401N18Rik, C130089L09Rik, Meg8 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021809 7574 ZNF26 http://www.ncbi.nlm.nih.gov/gene/?term=7574 "HEL-179, KOX20 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021810 75751 Ipo4 http://www.ncbi.nlm.nih.gov/gene/?term=75751 "8430408O15Rik, AA409693, Imp4a, RanBP4 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021811 75753 Klf17 http://www.ncbi.nlm.nih.gov/gene/?term=75753 "7420700M05Rik, AA420409, AU043468, C85123, D4Ertd561e, Gzf, Zfp393 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021812 75754 9030607L02Rik http://www.ncbi.nlm.nih.gov/gene/?term=75754 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021813 75763 Dcaf17 http://www.ncbi.nlm.nih.gov/gene/?term=75763 "2810055O12Rik, 4833418A01Rik, A030004A10Rik, A930009G19Rik, AI448937 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021814 75764 Slx1b http://www.ncbi.nlm.nih.gov/gene/?term=75764 "1110030E23Rik, 2410170E21Rik, 4833422P03Rik, AI853643, Giyd1, Giyd2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021815 75767 Rab11fip1 http://www.ncbi.nlm.nih.gov/gene/?term=75767 "2010200K21Rik, 4833414G05Rik, Rcp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021816 7576 ZNF28 http://www.ncbi.nlm.nih.gov/gene/?term=7576 KOX24 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021817 75775 4930402K13Rik http://www.ncbi.nlm.nih.gov/gene/?term=75775 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021818 75786 Ckap5 http://www.ncbi.nlm.nih.gov/gene/?term=75786 "3110043H24Rik, 4930432B04Rik, D730027C18Rik, T25636, mKIAA0097 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021819 75797 4930435N07Rik http://www.ncbi.nlm.nih.gov/gene/?term=75797 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021820 757 TMEM50B http://www.ncbi.nlm.nih.gov/gene/?term=757 "C21orf4, HCVP7TP3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021821 757 TMEM50B http://www.ncbi.nlm.nih.gov/gene/?term=757 "C21orf4, HCVP7TP3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021822 75801 4930447C04Rik http://www.ncbi.nlm.nih.gov/gene/?term=75801 "4921504I02Rik, A930035O15Rik, Six6OS, Six6as, Six6os1 " mRNA Mus musculus 15703187 Nucleus Embryonic tissue In situ hybridization|RT-PCR "We detected the expression in adult retina (postnatal day 30, P30) of Six3OS, Six6OS, Otx2OS, CrxOS and RaxOS (Fig. 3 and data not shown). In general, these transcripts were all expressed at higher levels in the inner nuclear layer (INL) and in the ganglion cell layer (GCL). " RLID00021823 75805 Nln http://www.ncbi.nlm.nih.gov/gene/?term=75805 "4930472G13Rik, C79345 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021824 7580 ZNF32 http://www.ncbi.nlm.nih.gov/gene/?term=7580 KOX30 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021825 7580 ZNF32 http://www.ncbi.nlm.nih.gov/gene/?term=7580 KOX30 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021826 7581 ZNF33A http://www.ncbi.nlm.nih.gov/gene/?term=7581 "KOX2, KOX31, KOX5, NF11A, ZNF11, ZNF11A, ZNF33, ZZAPK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021827 75838 4930560O18Rik http://www.ncbi.nlm.nih.gov/gene/?term=75838 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021828 75841 Rnf139 http://www.ncbi.nlm.nih.gov/gene/?term=75841 4930555P18Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021829 75842 4930556H04Rik http://www.ncbi.nlm.nih.gov/gene/?term=75842 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021830 7584 ZNF35 http://www.ncbi.nlm.nih.gov/gene/?term=7584 "HF.10, HF10, Zfp105 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021831 75858 Speer4cos http://www.ncbi.nlm.nih.gov/gene/?term=75858 "4930568L21Rik, SPEER-7, Speer7-ps, Speer7-ps1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021832 7586 ZKSCAN1 http://www.ncbi.nlm.nih.gov/gene/?term=7586 "9130423L19Rik, KOX18, PHZ-37, ZNF139, ZNF36, ZSCAN33 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021833 7586 ZKSCAN1 http://www.ncbi.nlm.nih.gov/gene/?term=7586 "9130423L19Rik, KOX18, PHZ-37, ZNF139, ZNF36, ZSCAN33 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021834 7586 ZKSCAN1 http://www.ncbi.nlm.nih.gov/gene/?term=7586 "9130423L19Rik, KOX18, PHZ-37, ZNF139, ZNF36, ZSCAN33 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021835 75872 4930568E02Rik http://www.ncbi.nlm.nih.gov/gene/?term=75872 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021836 7587 ZNF37A http://www.ncbi.nlm.nih.gov/gene/?term=7587 "KOX21, ZNF37 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021837 75937 4930594M17Rik http://www.ncbi.nlm.nih.gov/gene/?term=75937 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021838 75938 4930570E01Rik http://www.ncbi.nlm.nih.gov/gene/?term=75938 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021839 7593 MZF1 http://www.ncbi.nlm.nih.gov/gene/?term=7593 "MZF-1B, ZFP98, ZNF42, ZSCAN6, MZF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021840 7593 MZF1 http://www.ncbi.nlm.nih.gov/gene/?term=7593 "MZF-1, MZF1B, ZFP98, ZNF42, ZSCAN6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021841 7594 ZNF43 http://www.ncbi.nlm.nih.gov/gene/?term=7594 "HTF6, KOX27, ZNF39L1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021842 7594 ZNF43 http://www.ncbi.nlm.nih.gov/gene/?term=7594 "HTF6, KOX27, ZNF39L1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021843 7594 ZNF43 http://www.ncbi.nlm.nih.gov/gene/?term=7594 "HTF6, KOX27, ZNF39L1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021844 75957 Mir17hg http://www.ncbi.nlm.nih.gov/gene/?term=75957 "5033413D16Rik, Mirhg1, OTTMUSG00000033261, mir-17-92 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021845 75964 Trappc8 http://www.ncbi.nlm.nih.gov/gene/?term=75964 "5033403J15Rik, AI845423, D030074E01Rik, Trs85, mKIAA1012 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021846 75974 Dock11 http://www.ncbi.nlm.nih.gov/gene/?term=75974 "5033414A21Rik, 8030476J24, Zizimin2, sph238 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021847 75986 Agmat http://www.ncbi.nlm.nih.gov/gene/?term=75986 5033405N08Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021848 75990 5033421B08Rik http://www.ncbi.nlm.nih.gov/gene/?term=75990 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021849 759 CA1 http://www.ncbi.nlm.nih.gov/gene/?term=759 "CA-I, CAB, Car1, HEL-S-11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021850 76007 Zmym2 http://www.ncbi.nlm.nih.gov/gene/?term=76007 "5830413P05Rik, FIM, MYM, RAMP, SCLL, Zfp198, Znf198 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021851 76013 5830407E08Rik http://www.ncbi.nlm.nih.gov/gene/?term=76013 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021852 76016 5730406G12Rik http://www.ncbi.nlm.nih.gov/gene/?term=76016 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021853 76017 5830411K02Rik http://www.ncbi.nlm.nih.gov/gene/?term=76017 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021854 76022 Gon4l http://www.ncbi.nlm.nih.gov/gene/?term=76022 "1500041I23Rik, 2610100B20Rik, 3632445O20Rik, 5430404N14Rik, AA387005 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021855 76036 5830431N17Rik http://www.ncbi.nlm.nih.gov/gene/?term=76036 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021856 76044 Ncapg2 http://www.ncbi.nlm.nih.gov/gene/?term=76044 "5830426I05Rik, Luzp5, Mtb, mCAP-G2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021857 76045 5830449F15Rik http://www.ncbi.nlm.nih.gov/gene/?term=76045 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021858 76047 5830433M15Rik http://www.ncbi.nlm.nih.gov/gene/?term=76047 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021859 76051 Ganc http://www.ncbi.nlm.nih.gov/gene/?term=76051 "5830445O15Rik, 9330160A12, mFLJ00088 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021860 76053 5830426K05Rik http://www.ncbi.nlm.nih.gov/gene/?term=76053 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021861 76055 Mgea5 http://www.ncbi.nlm.nih.gov/gene/?term=76055 "2810009A20Rik, 4833427O07Rik, 5830447M11Rik, AA408215, Hy5, Ncoat, OGA, mKIAA0679 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021862 76066 5830435N17Rik http://www.ncbi.nlm.nih.gov/gene/?term=76066 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021863 760 CA2 http://www.ncbi.nlm.nih.gov/gene/?term=760 "CA-II, CAC, CAII, Car2, HEL-76, HEL-S-282 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021864 760 CA2 http://www.ncbi.nlm.nih.gov/gene/?term=760 "CA-II, CAC, CAII, Car2, HEL-76, HEL-S-282 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021865 76105 5830456J23Rik http://www.ncbi.nlm.nih.gov/gene/?term=76105 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021866 76105 5830456J23Rik http://www.ncbi.nlm.nih.gov/gene/?term=76105 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021867 76123 Gpsm2 http://www.ncbi.nlm.nih.gov/gene/?term=76123 "6230410J09Rik, LGN, Pins " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021868 76130 Las1l http://www.ncbi.nlm.nih.gov/gene/?term=76130 "1810030A06Rik, 5830482G23Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021869 76141 6230414M07Rik http://www.ncbi.nlm.nih.gov/gene/?term=76141 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021870 76156 Fam131b http://www.ncbi.nlm.nih.gov/gene/?term=76156 "6330503C03Rik, 6530406I18Rik, AV277466 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021871 76179 Usp31 http://www.ncbi.nlm.nih.gov/gene/?term=76179 "6330567E21Rik, mKIAA1203 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021872 76195 6330590E21Rik http://www.ncbi.nlm.nih.gov/gene/?term=76195 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021873 76199 Med13l http://www.ncbi.nlm.nih.gov/gene/?term=76199 "2210413I17Rik, 6330591G05Rik, 9030618F05Rik, Thrap2, Trap240L, mKIAA1025 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021874 76203 6430605C03Rik http://www.ncbi.nlm.nih.gov/gene/?term=76203 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021875 7620 ZNF69 http://www.ncbi.nlm.nih.gov/gene/?term=7620 "Cos5, hZNF3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021876 7620 ZNF69 http://www.ncbi.nlm.nih.gov/gene/?term=7620 "Cos5, hZNF3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021877 76213 6530406A20Rik http://www.ncbi.nlm.nih.gov/gene/?term=76213 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021878 76214 6430710M23Rik http://www.ncbi.nlm.nih.gov/gene/?term=76214 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021879 76217 Jakmip2 http://www.ncbi.nlm.nih.gov/gene/?term=76217 "6430702L21Rik, AI850334, D930046L20Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021880 76219 Arxes1 http://www.ncbi.nlm.nih.gov/gene/?term=76219 "6530401D17Rik, Spc22/23, Spcs3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021881 7621 ZNF70 http://www.ncbi.nlm.nih.gov/gene/?term=7621 Cos17 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021882 76222 Magef1 http://www.ncbi.nlm.nih.gov/gene/?term=76222 6430590I03Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021883 76223 Agbl3 http://www.ncbi.nlm.nih.gov/gene/?term=76223 "2900053G10Rik, 4930431N21Rik, 6530406M24Rik, CCP3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021884 76229 Vmn2r29 http://www.ncbi.nlm.nih.gov/gene/?term=76229 6430701C03Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021885 76246 Rtf1 http://www.ncbi.nlm.nih.gov/gene/?term=76246 "2900005O08Rik, 6530416A09Rik, AI853581, AU043144, AW553985, Gtl7, cbp82 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021886 76251 Ercc6l2 http://www.ncbi.nlm.nih.gov/gene/?term=76251 "0610007P08Rik, 1700019D06Rik, 9330134C04Rik, Rad26l, Sr278 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021887 7625 ZNF74 http://www.ncbi.nlm.nih.gov/gene/?term=7625 "COS52, ZFP520, ZNF520, hZNF7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021888 76260 Ttc8 http://www.ncbi.nlm.nih.gov/gene/?term=76260 "0610012F22Rik, AV001447, BBS8 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021889 76273 Ndfip2 http://www.ncbi.nlm.nih.gov/gene/?term=76273 "0710001O20Rik, 2810436B12Rik, 9130207N19Rik, N4wbp5a, mKIAA1165 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021890 7627 ZNF75A http://www.ncbi.nlm.nih.gov/gene/?term=7627 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021891 76281 Tax1bp3 http://www.ncbi.nlm.nih.gov/gene/?term=76281 "1300011C24Rik, TIP-1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021892 76295 Atp11b http://www.ncbi.nlm.nih.gov/gene/?term=76295 "1110019I14Rik, ATPIF, ATPIR, mKIAA0956 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021893 76299 Erp44 http://www.ncbi.nlm.nih.gov/gene/?term=76299 "1110001E24Rik, AI849526, AL033348, Txndc4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021894 7629 ZNF76 http://www.ncbi.nlm.nih.gov/gene/?term=7629 "D6S229E, ZNF523, Zfp523 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021895 76302 Pcnp http://www.ncbi.nlm.nih.gov/gene/?term=76302 "1110018D06Rik, AI647035 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021896 76308 Rab1b http://www.ncbi.nlm.nih.gov/gene/?term=76308 1110011F09Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021897 76311 1110019D14Rik http://www.ncbi.nlm.nih.gov/gene/?term=76311 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021898 76368 2610028L16Rik http://www.ncbi.nlm.nih.gov/gene/?term=76368 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021899 76376 Slc24a2 http://www.ncbi.nlm.nih.gov/gene/?term=76376 "2810021B17Rik, 6330417K15Rik, AI847460, Nckx2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021900 76390 Zfp735 http://www.ncbi.nlm.nih.gov/gene/?term=76390 1700012C15Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021901 76390 Zfp735 http://www.ncbi.nlm.nih.gov/gene/?term=76390 1700012C15Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021902 76416 Znrd1as http://www.ncbi.nlm.nih.gov/gene/?term=76416 "1700022C21Rik, AI746295, Znrd1-as " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021903 76425 Gid8 http://www.ncbi.nlm.nih.gov/gene/?term=76425 "2310003C23Rik, 4833420G11Rik, AI451474, Twa1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021904 76429 Lhpp http://www.ncbi.nlm.nih.gov/gene/?term=76429 2310007H09Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021905 76448 Ppp1r18 http://www.ncbi.nlm.nih.gov/gene/?term=76448 "2310014H01Rik, AA407849, AI450394 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021906 7644 ZNF91 http://www.ncbi.nlm.nih.gov/gene/?term=7644 "HPF7, HTF10 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021907 76454 Fbxo31 http://www.ncbi.nlm.nih.gov/gene/?term=76454 "1110003O08Rik, 2310046N15Rik, Fbx14, Fbxo14 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021908 76455 2310067E19Rik http://www.ncbi.nlm.nih.gov/gene/?term=76455 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021909 76457 Ccdc134 http://www.ncbi.nlm.nih.gov/gene/?term=76457 "2310042L06Rik, AW208859 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021910 76478 Haus8 http://www.ncbi.nlm.nih.gov/gene/?term=76478 "2410004L22Rik, Hice1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021911 76482 3110002H16Rik http://www.ncbi.nlm.nih.gov/gene/?term=76482 "2400010D15Rik, Mic-1, Mic1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021912 76485 Glt8d1 http://www.ncbi.nlm.nih.gov/gene/?term=76485 "2410004H05Rik, 5430414N14Rik, AI450005 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021913 76498 Paqr4 http://www.ncbi.nlm.nih.gov/gene/?term=76498 1500004C10Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021914 76501 Commd9 http://www.ncbi.nlm.nih.gov/gene/?term=76501 "1810029F08Rik, AA409293 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021915 76508 Ube2d-ps http://www.ncbi.nlm.nih.gov/gene/?term=76508 "1600028I17Rik, 2210015D19Rik, AI596465 " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021916 76510 Trappc9 http://www.ncbi.nlm.nih.gov/gene/?term=76510 "1810044A24Rik, 2900005P22Rik, 4632408O18Rik, Ibp, Nibp, TRS130, mKIAA1882 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021917 76522 Lsm8 http://www.ncbi.nlm.nih.gov/gene/?term=76522 "2010003I05Rik, AW214405, Naa38 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021918 76524 Cln6 http://www.ncbi.nlm.nih.gov/gene/?term=76524 "1810065L06Rik, AW743417, D9Bwg1455e, nclf " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021919 76533 2010106G04Rik http://www.ncbi.nlm.nih.gov/gene/?term=76533 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021920 76559 Atg2b http://www.ncbi.nlm.nih.gov/gene/?term=76559 "2410024A21Rik, AI047755, AI503411, AW558123, C030004M05Rik, C630028L02Rik, mKIAA4067 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021921 76581 2510001I10Rik http://www.ncbi.nlm.nih.gov/gene/?term=76581 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021922 76582 Ipo11 http://www.ncbi.nlm.nih.gov/gene/?term=76582 "1700081H05Rik, 2510001A17Rik, AI314624, AW555235, E330021B14Rik, Ranbp11 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021923 76585 Lce1i http://www.ncbi.nlm.nih.gov/gene/?term=76585 2310069N01Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021924 76594 Dnajc18 http://www.ncbi.nlm.nih.gov/gene/?term=76594 "2700075B01Rik, AU041129 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021925 76610 1700063K16Rik http://www.ncbi.nlm.nih.gov/gene/?term=76610 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021926 76613 1700069B07Rik http://www.ncbi.nlm.nih.gov/gene/?term=76613 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021927 76614 Immt http://www.ncbi.nlm.nih.gov/gene/?term=76614 "1700082C19Rik, D830041H16Rik, HMP, P87, P87/89, P89 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021928 76627 Prr30 http://www.ncbi.nlm.nih.gov/gene/?term=76627 1700110M21Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021929 76634 1700110C19Rik http://www.ncbi.nlm.nih.gov/gene/?term=76634 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021930 76671 5330406M23Rik http://www.ncbi.nlm.nih.gov/gene/?term=76671 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021931 76682 1500002K03Rik http://www.ncbi.nlm.nih.gov/gene/?term=76682 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). " RLID00021932 76686 Clip3 http://www.ncbi.nlm.nih.gov/gene/?term=76686 "1500005P14Rik, AI844915, Clipr-59 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021933 76687 Spcs3 http://www.ncbi.nlm.nih.gov/gene/?term=76687 1810011E08Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021934 76690 1500037F05Rik http://www.ncbi.nlm.nih.gov/gene/?term=76690 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021935 76707 Clasp1 http://www.ncbi.nlm.nih.gov/gene/?term=76707 "1700030C23Rik, 5730583A19Rik, B130045P17Rik, CLASP1alpha " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021936 76709 Arpc2 http://www.ncbi.nlm.nih.gov/gene/?term=76709 "2210023N03Rik, 34kDa, p34-Arc " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021937 76725 2010003D24Rik http://www.ncbi.nlm.nih.gov/gene/?term=76725 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021938 76740 Efr3a http://www.ncbi.nlm.nih.gov/gene/?term=76740 "A130089M23Rik, BB071175, C76891, C920006C10Rik, D030063F01Rik, mKIAA0143 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021939 76747 Dapl1 http://www.ncbi.nlm.nih.gov/gene/?term=76747 "2310032F03Rik, EEDA " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021940 7675 ZNF121 http://www.ncbi.nlm.nih.gov/gene/?term=7675 "D19S204, ZHC32, ZNF20 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021941 76763 Mospd2 http://www.ncbi.nlm.nih.gov/gene/?term=76763 2410013I23Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021942 76775 Slc10a7 http://www.ncbi.nlm.nih.gov/gene/?term=76775 "2410193C02Rik, P7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021943 76784 Mtif2 http://www.ncbi.nlm.nih.gov/gene/?term=76784 "2310038D14Rik, 2410112O06Rik, IF-2(Mt), IF-2mt, IF2(mt) " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021944 76789 Mzt1 http://www.ncbi.nlm.nih.gov/gene/?term=76789 "2410129H14Rik, AI120158, Mozart1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021945 7678 ZNF124 http://www.ncbi.nlm.nih.gov/gene/?term=7678 "HZF-16, HZF16, ZK7 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021946 7678 ZNF124 http://www.ncbi.nlm.nih.gov/gene/?term=7678 "HZF-16, HZF16, ZK7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021947 76794 Man2c1os http://www.ncbi.nlm.nih.gov/gene/?term=76794 "2410133F24Rik, AI851351 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021948 76798 Srrm4os http://www.ncbi.nlm.nih.gov/gene/?term=76798 2410137F16Rik lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021949 767 CA8 http://www.ncbi.nlm.nih.gov/gene/?term=767 "CA-RP, CA-VIII, CALS, CAMRQ3, CARP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021950 767 CA8 http://www.ncbi.nlm.nih.gov/gene/?term=767 "CA-VIII, CALS, CAMRQ3, CARP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021951 76800 Usp42 http://www.ncbi.nlm.nih.gov/gene/?term=76800 "2410140K03Rik, 3110031A07Rik, A630018G05Rik, D5Ertd591e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021952 76803 2410141K09Rik http://www.ncbi.nlm.nih.gov/gene/?term=76803 "4930482J15Rik, Ayu21-35, Gt(pU21)35Imeg " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021953 76804 Kdm4c http://www.ncbi.nlm.nih.gov/gene/?term=76804 "2410141F18Rik, AA517467, Gasc1, Jmjd2c " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021954 76813 Armc6 http://www.ncbi.nlm.nih.gov/gene/?term=76813 "2410153K17Rik, AW554412 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021955 768211 RELL1 http://www.ncbi.nlm.nih.gov/gene/?term=768211 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021956 768211 RELL1 http://www.ncbi.nlm.nih.gov/gene/?term=768211 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021957 768211 RELL1 http://www.ncbi.nlm.nih.gov/gene/?term=768211 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00021958 768420 COTL1 http://www.ncbi.nlm.nih.gov/gene/?term=768420 mRNA Gallus gallus 19951325 Axon Oculomotor nerve|Retina In situ hybridization "C-Coactosin mRNA is expressed in the oculomotor and trochlear nuclei and axon of oculomotor nerve (E, I) and trigeminal nerve (A, B). " RLID00021959 76843 Dtl http://www.ncbi.nlm.nih.gov/gene/?term=76843 "2810047L02Rik, 5730564G15Rik, L2dtl, Ramp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021960 76846 Rps9 http://www.ncbi.nlm.nih.gov/gene/?term=76846 "3010033P07Rik, AL022771, AL022885 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021961 76857 Spopl http://www.ncbi.nlm.nih.gov/gene/?term=76857 "4921517N04Rik, AU014935, BB233739, E430033K04Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021962 76863 Dcun1d5 http://www.ncbi.nlm.nih.gov/gene/?term=76863 "3110001A18Rik, 4833420K19Rik, AW060460, D430047L21Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021963 76877 Rab36 http://www.ncbi.nlm.nih.gov/gene/?term=76877 "6330593L16Rik, AW047545 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021964 76878 6330582A15Rik http://www.ncbi.nlm.nih.gov/gene/?term=76878 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021965 76892 Rnft1 http://www.ncbi.nlm.nih.gov/gene/?term=76892 "0610013E23Rik, AV007605 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021966 76893 Cers2 http://www.ncbi.nlm.nih.gov/gene/?term=76893 "0610013I17Rik, AI225939, Lass2, TRH3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021967 76895 Bicd2 http://www.ncbi.nlm.nih.gov/gene/?term=76895 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021968 768 CA9 http://www.ncbi.nlm.nih.gov/gene/?term=768 "CAIX, MN " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00021969 76900 Ssbp4 http://www.ncbi.nlm.nih.gov/gene/?term=76900 "1210002E11Rik, AW743380, Sspb4 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021970 7690 ZNF131 http://www.ncbi.nlm.nih.gov/gene/?term=7690 "ZBTB35, pHZ-10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021971 76916 Timmdc1 http://www.ncbi.nlm.nih.gov/gene/?term=76916 "2810021C21Rik, 4930455C21Rik, AV135763 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021972 7692 ZNF133 http://www.ncbi.nlm.nih.gov/gene/?term=7692 "ZNF150, pHZ-13, pHZ-66 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021973 76932 Arfip2 http://www.ncbi.nlm.nih.gov/gene/?term=76932 "2310002N04Rik, POR, Por1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021974 76936 Hnrnpm http://www.ncbi.nlm.nih.gov/gene/?term=76936 "2610023M21Rik, AA409009, Hnrpm, mKIAA4193 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021975 7693 ZNF134 http://www.ncbi.nlm.nih.gov/gene/?term=7693 pHZ-15 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021976 76967 2700049A03Rik http://www.ncbi.nlm.nih.gov/gene/?term=76967 "Ta3, Talpid3, mKIAA0586 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021977 76969 Chst1 http://www.ncbi.nlm.nih.gov/gene/?term=76969 "2610008E20Rik, AW125896, C6ST, GST-1, Gst1, KSGAL6ST " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021978 76971 Sult2a8 http://www.ncbi.nlm.nih.gov/gene/?term=76971 2810007J24Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021979 76972 Snhg20 http://www.ncbi.nlm.nih.gov/gene/?term=76972 2810008D09Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021980 76976 Arxes2 http://www.ncbi.nlm.nih.gov/gene/?term=76976 "2900062L11Rik, Spc22/23, Spcs3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021981 7697 ZNF138 http://www.ncbi.nlm.nih.gov/gene/?term=7697 pHZ-32 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021982 76982 3110035E14Rik http://www.ncbi.nlm.nih.gov/gene/?term=76982 "AI415019, AV164974, R75066 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021983 77015 Mpped2 http://www.ncbi.nlm.nih.gov/gene/?term=77015 "239Fb, 2700082O15Rik, AV354767, AW060960 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021984 7701 ZNF142 http://www.ncbi.nlm.nih.gov/gene/?term=7701 pHZ-49 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021985 77027 4432414F05Rik http://www.ncbi.nlm.nih.gov/gene/?term=77027 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021986 77031 Slc9a8 http://www.ncbi.nlm.nih.gov/gene/?term=77031 "1200006P13Rik, 6430709P13Rik, AI182282, NHE-8, NHE8 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021987 77038 Arfgap2 http://www.ncbi.nlm.nih.gov/gene/?term=77038 "2310032E02Rik, Zfp289 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021988 77038 Arfgap2 http://www.ncbi.nlm.nih.gov/gene/?term=77038 "2310032E02Rik, Zfp289 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021989 77041 Arsk http://www.ncbi.nlm.nih.gov/gene/?term=77041 "2810429K17Rik, 4833414G15Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021990 77045 Bcl7a http://www.ncbi.nlm.nih.gov/gene/?term=77045 "4432415N06Rik, AI448316 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021991 77048 Cep83 http://www.ncbi.nlm.nih.gov/gene/?term=77048 "2600001G24Rik, 4921537D05Rik, 5730513H21Rik, Ccdc41 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021992 77053 Sun1 http://www.ncbi.nlm.nih.gov/gene/?term=77053 "4632417G13Rik, 5730434D03Rik, Unc84a, mKIAA0810 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00021993 77059 4931408D14Rik http://www.ncbi.nlm.nih.gov/gene/?term=77059 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00021994 7705 ZNF146 http://www.ncbi.nlm.nih.gov/gene/?term=7705 OZF mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00021995 7705 ZNF146 http://www.ncbi.nlm.nih.gov/gene/?term=7705 OZF mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021996 7705 ZNF146 http://www.ncbi.nlm.nih.gov/gene/?term=7705 OZF mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021997 7706 TRIM25 http://www.ncbi.nlm.nih.gov/gene/?term=7706 "EFP, RNF147, Z147, ZNF147 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00021998 7706 TRIM25 http://www.ncbi.nlm.nih.gov/gene/?term=7706 "EFP, RNF147, Z147, ZNF147 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00021999 7707 ZNF148 http://www.ncbi.nlm.nih.gov/gene/?term=7707 "BERF-1, BFCOL1, HT-BETA, ZBP-89, ZFP148, pHZ-52 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022000 7707 ZNF148 http://www.ncbi.nlm.nih.gov/gene/?term=7707 "BERF-1, BFCOL1, HT-BETA, ZBP-89, ZFP148, pHZ-52 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022001 77087 Ankrd11 http://www.ncbi.nlm.nih.gov/gene/?term=77087 "2410104C19Rik, 3010027A04Rik, 6330578C09Rik, 9530048I21Rik, AA930108, Gm176, Yod " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022002 77088 3010031K01Rik http://www.ncbi.nlm.nih.gov/gene/?term=77088 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022003 77090 Ocel1 http://www.ncbi.nlm.nih.gov/gene/?term=77090 "9430098E02Rik, AI326022, AI593544 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022004 77097 Tanc2 http://www.ncbi.nlm.nih.gov/gene/?term=77097 "3526402J09Rik, 5730590C14Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022005 7709 ZBTB17 http://www.ncbi.nlm.nih.gov/gene/?term=7709 "MIZ-1, ZNF151, ZNF60, pHZ-67 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022006 770 CA11 http://www.ncbi.nlm.nih.gov/gene/?term=770 CARPX1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022007 77106 Tmem181a http://www.ncbi.nlm.nih.gov/gene/?term=77106 "5930418K15Rik, C76977, Gpr178, Tmem181, mKIAA1423 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022008 77106 Tmem181a http://www.ncbi.nlm.nih.gov/gene/?term=77106 "5930418K15Rik, C76977, Gpr178, Tmem181, mKIAA1423 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022009 77113 Klhl2 http://www.ncbi.nlm.nih.gov/gene/?term=77113 "6030411N21Rik, ABP-KELCH, AU020744, Mav " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022010 77116 Mtmr2 http://www.ncbi.nlm.nih.gov/gene/?term=77116 6030445P13Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022011 77128 Crebrf http://www.ncbi.nlm.nih.gov/gene/?term=77128 "A930001N09Rik, LRF " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022012 7716 VEZF1 http://www.ncbi.nlm.nih.gov/gene/?term=7716 "DB1, ZNF161 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022013 7716 VEZF1 http://www.ncbi.nlm.nih.gov/gene/?term=7716 "DB1, ZNF161 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022014 77189 A430105J06Rik http://www.ncbi.nlm.nih.gov/gene/?term=77189 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022015 7718 ZNF165 http://www.ncbi.nlm.nih.gov/gene/?term=7718 "CT53, LD65, ZSCAN7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022016 77198 4930407I19Rik http://www.ncbi.nlm.nih.gov/gene/?term=77198 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022017 771 CA12 http://www.ncbi.nlm.nih.gov/gene/?term=771 "CAXII, HsT18816 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022018 77200 5430403G16Rik http://www.ncbi.nlm.nih.gov/gene/?term=77200 ENSMUSG00000072763 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022019 77210 8030448I15Rik http://www.ncbi.nlm.nih.gov/gene/?term=77210 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022020 77216 A930002H02Rik http://www.ncbi.nlm.nih.gov/gene/?term=77216 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022021 77247 9430006E15Rik http://www.ncbi.nlm.nih.gov/gene/?term=77247 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022022 77248 9430014N10Rik http://www.ncbi.nlm.nih.gov/gene/?term=77248 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022023 7726 TRIM26 http://www.ncbi.nlm.nih.gov/gene/?term=7726 "AFP, RNF95, ZNF173 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022024 7727 ZNF174 http://www.ncbi.nlm.nih.gov/gene/?term=7727 ZSCAN8 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022025 7727 ZNF174 http://www.ncbi.nlm.nih.gov/gene/?term=7727 ZSCAN8 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022026 77289 9430034F23Rik http://www.ncbi.nlm.nih.gov/gene/?term=77289 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022027 77301 9430031J08Rik http://www.ncbi.nlm.nih.gov/gene/?term=77301 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022028 77304 9430068D22Rik http://www.ncbi.nlm.nih.gov/gene/?term=77304 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022029 77311 C030011I16Rik http://www.ncbi.nlm.nih.gov/gene/?term=77311 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022030 77352 Axdnd1 http://www.ncbi.nlm.nih.gov/gene/?term=77352 "9430070O13Rik, Gm979 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022031 77365 9430083B18Rik http://www.ncbi.nlm.nih.gov/gene/?term=77365 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022032 77371 Sec24a http://www.ncbi.nlm.nih.gov/gene/?term=77371 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022033 7737 RNF113A http://www.ncbi.nlm.nih.gov/gene/?term=7737 "Cwc24, RNF113, TTD5, ZNF183 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022034 7738 ZNF184 http://www.ncbi.nlm.nih.gov/gene/?term=7738 kr-ZNF3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022035 7738 ZNF184 http://www.ncbi.nlm.nih.gov/gene/?term=7738 kr-ZNF3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022036 77393 9530006C21Rik http://www.ncbi.nlm.nih.gov/gene/?term=77393 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022037 77406 9530004M16Rik http://www.ncbi.nlm.nih.gov/gene/?term=77406 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022038 77415 C030015E24Rik http://www.ncbi.nlm.nih.gov/gene/?term=77415 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022039 7741 ZSCAN26 http://www.ncbi.nlm.nih.gov/gene/?term=7741 "SRE-ZBP, SREZBP, ZNF187 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022040 77439 9530025L08Rik http://www.ncbi.nlm.nih.gov/gene/?term=77439 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022041 77440 9430087N24Rik http://www.ncbi.nlm.nih.gov/gene/?term=77440 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022042 77463 C030014O09Rik http://www.ncbi.nlm.nih.gov/gene/?term=77463 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022043 7746 ZSCAN9 http://www.ncbi.nlm.nih.gov/gene/?term=7746 "PRD51, ZNF193 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022044 77479 C030040K24Rik http://www.ncbi.nlm.nih.gov/gene/?term=77479 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022045 77481 C030048H21Rik http://www.ncbi.nlm.nih.gov/gene/?term=77481 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022046 7748 ZNF195 http://www.ncbi.nlm.nih.gov/gene/?term=7748 "HRF1, ZNFP104 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022047 7748 ZNF195 http://www.ncbi.nlm.nih.gov/gene/?term=7748 "HRF1, ZNFP104 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022048 7748 ZNF195 http://www.ncbi.nlm.nih.gov/gene/?term=7748 "HRF1, ZNFP104 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022049 77492 8030456M14Rik http://www.ncbi.nlm.nih.gov/gene/?term=77492 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022050 7750 ZMYM2 http://www.ncbi.nlm.nih.gov/gene/?term=7750 "FIM, MYM, RAMP, SCLL, ZNF198 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022051 7750 ZMYM2 http://www.ncbi.nlm.nih.gov/gene/?term=7750 "FIM, MYM, RAMP, SCLL, ZNF198 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022052 77511 9330185C12Rik http://www.ncbi.nlm.nih.gov/gene/?term=77511 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022053 77519 Zfp266 http://www.ncbi.nlm.nih.gov/gene/?term=77519 "5330440G10Rik, 5730601F06Rik, AW552317 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022054 7752 ZNF200 http://www.ncbi.nlm.nih.gov/gene/?term=7752 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022055 7753 ZNF202 http://www.ncbi.nlm.nih.gov/gene/?term=7753 "ZKSCAN10, ZSCAN42 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022056 7753 ZNF202 http://www.ncbi.nlm.nih.gov/gene/?term=7753 "ZKSCAN10, ZSCAN42 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022057 77544 8030479D07Rik http://www.ncbi.nlm.nih.gov/gene/?term=77544 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022058 7756 ZNF207 http://www.ncbi.nlm.nih.gov/gene/?term=7756 "BuGZ, hBuGZ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022059 77579 Myh10 http://www.ncbi.nlm.nih.gov/gene/?term=77579 "5730504C04Rik, 9330167F11Rik, Fltn, Myhn-2, Myhn2, NMHC II-B, NMHC-B, NMHCII-B, NMMHC II-b, NMMHC-B, NMMHC-IIB, SMemb, mKIAA3005 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022060 7757 ZNF208 http://www.ncbi.nlm.nih.gov/gene/?term=7757 "PMIDP, ZNF95 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022061 7757 ZNF208 http://www.ncbi.nlm.nih.gov/gene/?term=7757 "PMIDP, ZNF95 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022062 77591 Ddx10 http://www.ncbi.nlm.nih.gov/gene/?term=77591 "4632415A01Rik, AI646054 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022063 77596 Adgrf1 http://www.ncbi.nlm.nih.gov/gene/?term=77596 "5031409J19Rik, Gpr110, KPG_009 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022064 775 CACNA1C http://www.ncbi.nlm.nih.gov/gene/?term=775 "CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, TS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022065 77605 H2afv http://www.ncbi.nlm.nih.gov/gene/?term=77605 "C530002L11Rik, H2a.z-2, H2av " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022066 77610 C330002G04Rik http://www.ncbi.nlm.nih.gov/gene/?term=77610 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022067 77612 C030038I04Rik http://www.ncbi.nlm.nih.gov/gene/?term=77612 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022068 77622 Apex2 http://www.ncbi.nlm.nih.gov/gene/?term=77622 "C430040P13Rik, ape2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022069 77634 Snapc3 http://www.ncbi.nlm.nih.gov/gene/?term=77634 "1810020H02Rik, 4930558A07Rik, 5031401C21Rik, AI414457, E030018J20Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022070 7763 ZFAND5 http://www.ncbi.nlm.nih.gov/gene/?term=7763 "ZA20D2A, ZNF216, ZFAND5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022071 7763 ZFAND5 http://www.ncbi.nlm.nih.gov/gene/?term=7763 "ZA20D2A, ZNF216, ZFAND5 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022072 7763 ZFAND5 http://www.ncbi.nlm.nih.gov/gene/?term=7763 "ZA20D2A, ZNF216, ZFAND5 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022073 7764 ZNF217 http://www.ncbi.nlm.nih.gov/gene/?term=7764 ZABC1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022074 77656 C430045I18Rik http://www.ncbi.nlm.nih.gov/gene/?term=77656 C78534 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022075 77656 C430045I18Rik http://www.ncbi.nlm.nih.gov/gene/?term=77656 C78534 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022076 77683 Ehmt1 http://www.ncbi.nlm.nih.gov/gene/?term=77683 "9230102N17Rik, D330003E03, Eu-HMTase1, GLP, GLP1, KMT1D, mKIAA1876 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022077 7769 ZNF226 http://www.ncbi.nlm.nih.gov/gene/?term=7769 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022078 776 CACNA1D http://www.ncbi.nlm.nih.gov/gene/?term=776 "CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, PASNA, SANDD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022079 77700 9130208D14Rik http://www.ncbi.nlm.nih.gov/gene/?term=77700 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022080 77702 9130201A16Rik http://www.ncbi.nlm.nih.gov/gene/?term=77702 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022081 77707 9130604C24Rik http://www.ncbi.nlm.nih.gov/gene/?term=77707 AW554730 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022082 77708 9130223C08Rik http://www.ncbi.nlm.nih.gov/gene/?term=77708 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022083 77719 6030458A19Rik http://www.ncbi.nlm.nih.gov/gene/?term=77719 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022084 77724 6030460B20Rik http://www.ncbi.nlm.nih.gov/gene/?term=77724 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022085 77755 A230103L15Rik http://www.ncbi.nlm.nih.gov/gene/?term=77755 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022086 77760 A230106O10Rik http://www.ncbi.nlm.nih.gov/gene/?term=77760 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022087 77761 9230118N01Rik http://www.ncbi.nlm.nih.gov/gene/?term=77761 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022088 77766 Elp4 http://www.ncbi.nlm.nih.gov/gene/?term=77766 "A330107A17Rik, Paxneb " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022089 7776 ZNF236 http://www.ncbi.nlm.nih.gov/gene/?term=7776 "ZNF236AB, ZNF236 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022090 7776 ZNF236 http://www.ncbi.nlm.nih.gov/gene/?term=7776 "ZNF236AB, ZNF236 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022091 77777 Ulbp1 http://www.ncbi.nlm.nih.gov/gene/?term=77777 "A430108B07Rik, MULT1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022092 77781 Epm2aip1 http://www.ncbi.nlm.nih.gov/gene/?term=77781 "A930003G21Rik, mKIAA0766 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022093 77782 Polq http://www.ncbi.nlm.nih.gov/gene/?term=77782 A430110D14Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022094 77790 A930006J02Rik http://www.ncbi.nlm.nih.gov/gene/?term=77790 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022095 77799 Sla2 http://www.ncbi.nlm.nih.gov/gene/?term=77799 "A930009E21Rik, AI430952, SLAP-2, SLAP2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022096 7779 SLC30A1 http://www.ncbi.nlm.nih.gov/gene/?term=7779 "ZNT1, ZRC1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022097 7779 SLC30A1 http://www.ncbi.nlm.nih.gov/gene/?term=7779 "ZNT1, ZRC1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022098 77803 Fam159b http://www.ncbi.nlm.nih.gov/gene/?term=77803 A930021C24Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022099 77813 A930012N16Rik http://www.ncbi.nlm.nih.gov/gene/?term=77813 C78811 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022100 7781 SLC30A3 http://www.ncbi.nlm.nih.gov/gene/?term=7781 ZNT3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022101 77825 A930027M08Rik http://www.ncbi.nlm.nih.gov/gene/?term=77825 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022102 7782 SLC30A4 http://www.ncbi.nlm.nih.gov/gene/?term=7782 "ZNT4, znT-4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022103 7782 SLC30A4 http://www.ncbi.nlm.nih.gov/gene/?term=7782 "ZNT4, znT-4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022104 77838 A930036M01Rik http://www.ncbi.nlm.nih.gov/gene/?term=77838 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022105 77841 Far2os2 http://www.ncbi.nlm.nih.gov/gene/?term=77841 B230104C08Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022106 7784 ZP3 http://www.ncbi.nlm.nih.gov/gene/?term=7784 "ZP3AB, ZPC, Zp-3, ZP3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022107 77850 B830007D08Rik http://www.ncbi.nlm.nih.gov/gene/?term=77850 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022108 77857 9430065F17Rik http://www.ncbi.nlm.nih.gov/gene/?term=77857 E130110G22Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022109 77877 6030458C11Rik http://www.ncbi.nlm.nih.gov/gene/?term=77877 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022110 77884 6720427H10Rik http://www.ncbi.nlm.nih.gov/gene/?term=77884 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022111 77889 Lbh http://www.ncbi.nlm.nih.gov/gene/?term=77889 "1810009F10Rik, 6720416L16Rik " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022112 779157 slc12a9 http://www.ncbi.nlm.nih.gov/gene/?term=779157 cip1 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00022113 7791 ZYX http://www.ncbi.nlm.nih.gov/gene/?term=7791 "ESP-2, HED-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022114 77938 Fam53b http://www.ncbi.nlm.nih.gov/gene/?term=77938 "A930008G19Rik, mKIAA0140 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022115 77942 A930006A01Rik http://www.ncbi.nlm.nih.gov/gene/?term=77942 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022116 77951 Cyp20a1 http://www.ncbi.nlm.nih.gov/gene/?term=77951 "A930011N14Rik, Cypm " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022117 77963 Hook1 http://www.ncbi.nlm.nih.gov/gene/?term=77963 "A930033L17Rik, azh " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022118 77967 A930036I15Rik http://www.ncbi.nlm.nih.gov/gene/?term=77967 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022119 77968 A930041D05Rik http://www.ncbi.nlm.nih.gov/gene/?term=77968 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022120 77972 A930037G07Rik http://www.ncbi.nlm.nih.gov/gene/?term=77972 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022121 779853 aen http://www.ncbi.nlm.nih.gov/gene/?term=779853 "isg20l1, xaen " mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00022122 77988 D730047N16Rik http://www.ncbi.nlm.nih.gov/gene/?term=77988 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022123 7798 LUZP1 http://www.ncbi.nlm.nih.gov/gene/?term=7798 LUZP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022124 77991 D730048M19Rik http://www.ncbi.nlm.nih.gov/gene/?term=77991 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022125 77996 Cutal http://www.ncbi.nlm.nih.gov/gene/?term=77996 D730039F16Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022126 7799 PRDM2 http://www.ncbi.nlm.nih.gov/gene/?term=7799 "HUMHOXY1, KMT8, MTB-ZF, RIZ, RIZ1, RIZ2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022127 78010 4930465I24Rik http://www.ncbi.nlm.nih.gov/gene/?term=78010 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022128 780193 acp6 http://www.ncbi.nlm.nih.gov/gene/?term=780193 mRNA Xenopus tropicalis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00022129 7802 DNALI1 http://www.ncbi.nlm.nih.gov/gene/?term=7802 "P28, dJ423B22.5, hp28 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022130 7803 PTP4A1 http://www.ncbi.nlm.nih.gov/gene/?term=7803 "HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022131 7803 PTP4A1 http://www.ncbi.nlm.nih.gov/gene/?term=7803 "HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022132 7804 LRP8 http://www.ncbi.nlm.nih.gov/gene/?term=7804 "APOER2, HSZ75190, LRP-8, MCI1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022133 7804 LRP8 http://www.ncbi.nlm.nih.gov/gene/?term=7804 "APOER2, HSZ75190, LRP-8, MCI1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022134 7805 LAPTM5 http://www.ncbi.nlm.nih.gov/gene/?term=7805 CLAST6 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022135 780776 TVP23A http://www.ncbi.nlm.nih.gov/gene/?term=780776 "FAM18A, YDR084C " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022136 780776 TVP23A http://www.ncbi.nlm.nih.gov/gene/?term=780776 "FAM18A, YDR084C " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022137 78078 9230108I15Rik http://www.ncbi.nlm.nih.gov/gene/?term=78078 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022138 780851 SNORD3A http://www.ncbi.nlm.nih.gov/gene/?term=780851 "RNU3, U3 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022139 780851 SNORD3A http://www.ncbi.nlm.nih.gov/gene/?term=780851 "RNU3, U3 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022140 780851 SNORD3A http://www.ncbi.nlm.nih.gov/gene/?term=780851 "RNU3, U3 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022141 780852 SNORD3B-2 http://www.ncbi.nlm.nih.gov/gene/?term=780852 "U3-2B, U3b2 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022142 780852 SNORD3B-2 http://www.ncbi.nlm.nih.gov/gene/?term=780852 "U3-2B, U3b2 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022143 780852 SNORD3B-2 http://www.ncbi.nlm.nih.gov/gene/?term=780852 "U3-2B, U3b2 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022144 780853 SNORD3C http://www.ncbi.nlm.nih.gov/gene/?term=780853 U3-3 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022145 780853 SNORD3C http://www.ncbi.nlm.nih.gov/gene/?term=780853 U3-3 snoRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00022146 780853 SNORD3C http://www.ncbi.nlm.nih.gov/gene/?term=780853 U3-3 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022147 780853 SNORD3C http://www.ncbi.nlm.nih.gov/gene/?term=780853 U3-3 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022148 780854 SNORD3D http://www.ncbi.nlm.nih.gov/gene/?term=780854 U3-4 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022149 780854 SNORD3D http://www.ncbi.nlm.nih.gov/gene/?term=780854 U3-4 snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022150 780854 SNORD3D http://www.ncbi.nlm.nih.gov/gene/?term=780854 U3-4 snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022151 780 DDR1 http://www.ncbi.nlm.nih.gov/gene/?term=780 "CAK, CD167, DDR, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022152 780 DDR1 http://www.ncbi.nlm.nih.gov/gene/?term=780 "CAK, CD167, DDR, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022153 78100 Msantd4 http://www.ncbi.nlm.nih.gov/gene/?term=78100 "8430410K20Rik, Mysantd4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022154 78102 8430426J06Rik http://www.ncbi.nlm.nih.gov/gene/?term=78102 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022155 78107 4930425F17Rik http://www.ncbi.nlm.nih.gov/gene/?term=78107 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022156 7812 CSDE1 http://www.ncbi.nlm.nih.gov/gene/?term=7812 "D1S155E, UNR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022157 7812 CSDE1 http://www.ncbi.nlm.nih.gov/gene/?term=7812 "D1S155E, UNR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022158 7813 EVI5 http://www.ncbi.nlm.nih.gov/gene/?term=7813 "EVI-5, NB4S " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022159 7813 EVI5 http://www.ncbi.nlm.nih.gov/gene/?term=7813 "EVI-5, NB4S " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022160 7813 EVI5 http://www.ncbi.nlm.nih.gov/gene/?term=7813 "EVI-5, NB4S " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022161 78195 4930528J18Rik http://www.ncbi.nlm.nih.gov/gene/?term=78195 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022162 781 CACNA2D1 http://www.ncbi.nlm.nih.gov/gene/?term=781 "CACNA2, CACNL2A, CCHL2A, LINC01112, lncRNA-N3 " lncRNA Homo sapiens 22193719 Nucleus Embryonic stem cell qRT-PCR|Microarray "Figure 7: Neuronal lncRNAs act via diverse mechanisms. (A) Quantification of relative expression of lncRNAs in nuclear and cytoplasmic cell fractions. (B) Quantification of changes in hosted miRNAs in response to lncRNA_N2 knockdown. MiRNAs were quantified using Taqman miRNA qPCR. (C-E) RIP of lncRNAs with SUZ12 and REST antibodies. The interaction of HOTAIR with SUZ12 is a known interaction that serves as a positive control (Gupta et al, 2010). * and ** indicate P-values of <0.05 and <0.01, respectively. Data are collected from Figure 7. " RLID00022163 78230 5033405D04Rik http://www.ncbi.nlm.nih.gov/gene/?term=78230 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022164 78232 Trappc6b http://www.ncbi.nlm.nih.gov/gene/?term=78232 "5830498C14Rik, C79212 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022165 78244 Dnajc21 http://www.ncbi.nlm.nih.gov/gene/?term=78244 "4930461P20Rik, 9930116P15Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022166 78246 Phf23 http://www.ncbi.nlm.nih.gov/gene/?term=78246 42522 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022167 78251 Zfp712 http://www.ncbi.nlm.nih.gov/gene/?term=78251 "4921504N20Rik, mszf31, mszf89 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022168 78252 Nxpe2 http://www.ncbi.nlm.nih.gov/gene/?term=78252 "4432416J03Rik, AI323362, Fam55b " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022169 78255 Ralgps2 http://www.ncbi.nlm.nih.gov/gene/?term=78255 "1810020P17Rik, 2210408F11Rik, 4921528G01Rik, 9130014M22Rik, AU043409, AW046161 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022170 78265 4632418H02Rik http://www.ncbi.nlm.nih.gov/gene/?term=78265 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022171 78267 Klhdc8b http://www.ncbi.nlm.nih.gov/gene/?term=78267 4931406O17Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022172 78276 5330433J24Rik http://www.ncbi.nlm.nih.gov/gene/?term=78276 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022173 78283 Map7d2 http://www.ncbi.nlm.nih.gov/gene/?term=78283 "1600028E09Rik, 2900002G04Rik, 5330432J06Rik, C030036K04Rik, Mtap7d2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022174 78294 Rps27a http://www.ncbi.nlm.nih.gov/gene/?term=78294 "0610006J14Rik, Uba52, Ubb, Ubc " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022175 78294 Rps27a http://www.ncbi.nlm.nih.gov/gene/?term=78294 "0610006J14Rik, Uba52, Ubb, Ubc " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00022176 782 CACNB1 http://www.ncbi.nlm.nih.gov/gene/?term=782 "CAB1, CACNLB1, CCHLB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022177 78303 Hist3h2ba http://www.ncbi.nlm.nih.gov/gene/?term=78303 "1500011O09Rik, AI413321 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022178 78332 2510010K19Rik http://www.ncbi.nlm.nih.gov/gene/?term=78332 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022179 78372 Snrnp25 http://www.ncbi.nlm.nih.gov/gene/?term=78372 "3300001G02Rik, AL033324, C16ORF33 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022180 78376 Sapcd1 http://www.ncbi.nlm.nih.gov/gene/?term=78376 "2810436B06Rik, G7d, Ng23 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022181 7837 PXDN http://www.ncbi.nlm.nih.gov/gene/?term=7837 "COPOA, D2S448, D2S448E, MG50, PRG2, PXN, VPO " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00022182 7837 PXDN http://www.ncbi.nlm.nih.gov/gene/?term=7837 "COPOA, D2S448, D2S448E, MG50, PRG2, PXN, VPO " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022183 7837 PXDN http://www.ncbi.nlm.nih.gov/gene/?term=7837 "COPOA, D2S448, D2S448E, MG50, PRG2, PXN, VPO " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022184 78385 2310063J23Rik http://www.ncbi.nlm.nih.gov/gene/?term=78385 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022185 78388 Mvp http://www.ncbi.nlm.nih.gov/gene/?term=78388 "2310009M24Rik, LRP, VAULT1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022186 78396 2810028B13Rik http://www.ncbi.nlm.nih.gov/gene/?term=78396 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022187 7840 ALMS1 http://www.ncbi.nlm.nih.gov/gene/?term=7840 ALSS mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022188 7841 MOGS http://www.ncbi.nlm.nih.gov/gene/?term=7841 "CDG2B, CWH41, DER7, GCS1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022189 7841 MOGS http://www.ncbi.nlm.nih.gov/gene/?term=7841 "CDG2B, CWH41, DER7, GCS1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022190 78425 9530053H05Rik http://www.ncbi.nlm.nih.gov/gene/?term=78425 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022191 78435 A930014E10Rik http://www.ncbi.nlm.nih.gov/gene/?term=78435 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022192 7844 RNF103 http://www.ncbi.nlm.nih.gov/gene/?term=7844 "HKF-1, KF-1, KF1, ZFP-103, ZFP103 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022193 7844 RNF103 http://www.ncbi.nlm.nih.gov/gene/?term=7844 "HKF-1, KF-1, KF1, ZFP-103, ZFP103 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022194 78455 Helz http://www.ncbi.nlm.nih.gov/gene/?term=78455 "3110078M01Rik, 9430093I07Rik, 9630002H22Rik, AI851979, DRHC " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022195 78456 C030002A05Rik http://www.ncbi.nlm.nih.gov/gene/?term=78456 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022196 7846 TUBA1A http://www.ncbi.nlm.nih.gov/gene/?term=7846 "B-ALPHA-1, LIS3, TUBA3 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022197 7846 TUBA1A http://www.ncbi.nlm.nih.gov/gene/?term=7846 "B-ALPHA-1, LIS3, TUBA3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022198 78477 1700121M21Rik http://www.ncbi.nlm.nih.gov/gene/?term=78477 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022199 7849 PAX8 http://www.ncbi.nlm.nih.gov/gene/?term=7849 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022200 784 CACNB3 http://www.ncbi.nlm.nih.gov/gene/?term=784 "CAB3, CACNLB3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022201 7850 IL1R2 http://www.ncbi.nlm.nih.gov/gene/?term=7850 "CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022202 78514 Arhgap10 http://www.ncbi.nlm.nih.gov/gene/?term=78514 "A930033B01Rik, PSGAP-m, PSGAP-s " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022203 7851 MALL http://www.ncbi.nlm.nih.gov/gene/?term=7851 BENE mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022204 7851 MALL http://www.ncbi.nlm.nih.gov/gene/?term=7851 BENE mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022205 7851 MALL http://www.ncbi.nlm.nih.gov/gene/?term=7851 BENE mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022206 78521 B230219D22Rik http://www.ncbi.nlm.nih.gov/gene/?term=78521 "AA119856, D530037I19Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022207 78523 Mrpl9 http://www.ncbi.nlm.nih.gov/gene/?term=78523 "8030480E20Rik, AA409733, C330013D18Rik, L9mt " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022208 78526 Platr21 http://www.ncbi.nlm.nih.gov/gene/?term=78526 C330013F16Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022209 7852 CXCR4 http://www.ncbi.nlm.nih.gov/gene/?term=7852 "CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022210 7852 CXCR4 http://www.ncbi.nlm.nih.gov/gene/?term=7852 "CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022211 78551 5430407F15Rik http://www.ncbi.nlm.nih.gov/gene/?term=78551 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022212 78558 Htra3 http://www.ncbi.nlm.nih.gov/gene/?term=78558 "2210021K23Rik, 9530081K03Rik, Prsp, Tasp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022213 7855 FZD5 http://www.ncbi.nlm.nih.gov/gene/?term=7855 "C2orf31, HFZ5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022214 7855 FZD5 http://www.ncbi.nlm.nih.gov/gene/?term=7855 "C2orf31, HFZ5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022215 78570 9630014C11Rik http://www.ncbi.nlm.nih.gov/gene/?term=78570 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022216 78573 D530037P16Rik http://www.ncbi.nlm.nih.gov/gene/?term=78573 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022217 78575 B430319G15Rik http://www.ncbi.nlm.nih.gov/gene/?term=78575 D530025C14Rik lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022218 78579 D530043N20Rik http://www.ncbi.nlm.nih.gov/gene/?term=78579 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022219 7857 SCG2 http://www.ncbi.nlm.nih.gov/gene/?term=7857 "CHGC, EM66, SN, SgII " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022220 78618 Acap2 http://www.ncbi.nlm.nih.gov/gene/?term=78618 "4832442G16, 9530039J15Rik, CNT-B2, Centb2, mKIAA0041 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022221 7862 BRPF1 http://www.ncbi.nlm.nih.gov/gene/?term=7862 BR140 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022222 7862 BRPF1 http://www.ncbi.nlm.nih.gov/gene/?term=7862 BR140 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022223 78633 1700096C16Rik http://www.ncbi.nlm.nih.gov/gene/?term=78633 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022224 78634 Spaca7 http://www.ncbi.nlm.nih.gov/gene/?term=78634 1700094C09Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022225 78642 1700127F24Rik http://www.ncbi.nlm.nih.gov/gene/?term=78642 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022226 78653 Bola3 http://www.ncbi.nlm.nih.gov/gene/?term=78653 1810056O20Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022227 78654 1700066C05Rik http://www.ncbi.nlm.nih.gov/gene/?term=78654 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022228 78656 Brd8 http://www.ncbi.nlm.nih.gov/gene/?term=78656 "2610007E11Rik, 4432404P07Rik, SMAP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022229 78658 Ncapd3 http://www.ncbi.nlm.nih.gov/gene/?term=78658 "2810487N22Rik, 4632407J06Rik, AI195468, AU018739, B130055D15Rik, mKIAA0056 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022230 7866 IFRD2 http://www.ncbi.nlm.nih.gov/gene/?term=7866 "IFNRP, SKMc15, SM15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022231 7866 IFRD2 http://www.ncbi.nlm.nih.gov/gene/?term=7866 "IFNRP, SKMc15, SM15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022232 78672 9530057J20Rik http://www.ncbi.nlm.nih.gov/gene/?term=78672 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022233 7867 MAPKAPK3 http://www.ncbi.nlm.nih.gov/gene/?term=7867 "3PK, MAPKAP-K3, MAPKAP3, MAPKAPK-3, MK-3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022234 7867 MAPKAPK3 http://www.ncbi.nlm.nih.gov/gene/?term=7867 "3PK, MAPKAP-K3, MAPKAP3, MAPKAPK-3, MK-3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022235 7867 MAPKAPK3 http://www.ncbi.nlm.nih.gov/gene/?term=7867 "3PK, MAPKAP-K3, MAPKAP3, MAPKAPK-3, MK-3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022236 78688 Nol3 http://www.ncbi.nlm.nih.gov/gene/?term=78688 "ARC, B430311C09Rik, MYC, NOP, Nop30 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022237 78689 Naa35 http://www.ncbi.nlm.nih.gov/gene/?term=78689 "A330021G12Rik, A330027C19Rik, AI158944, C030004C14Rik, Mak10 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022238 78693 C030004M13Rik http://www.ncbi.nlm.nih.gov/gene/?term=78693 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022239 78697 Pus7 http://www.ncbi.nlm.nih.gov/gene/?term=78697 C330017I15Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022240 7871 SLMAP http://www.ncbi.nlm.nih.gov/gene/?term=7871 SLAP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022241 7871 SLMAP http://www.ncbi.nlm.nih.gov/gene/?term=7871 SLAP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022242 7871 SLMAP http://www.ncbi.nlm.nih.gov/gene/?term=7871 SLAP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022243 7873 MANF http://www.ncbi.nlm.nih.gov/gene/?term=7873 "ARMET, ARP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022244 7873 MANF http://www.ncbi.nlm.nih.gov/gene/?term=7873 "ARMET, ARP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022245 78745 9530097N15Rik http://www.ncbi.nlm.nih.gov/gene/?term=78745 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022246 7874 USP7 http://www.ncbi.nlm.nih.gov/gene/?term=7874 "HAUSP, TEF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022247 7874 USP7 http://www.ncbi.nlm.nih.gov/gene/?term=7874 "HAUSP, TEF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022248 78790 4930414F18Rik http://www.ncbi.nlm.nih.gov/gene/?term=78790 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022249 78792 4930432F04Rik http://www.ncbi.nlm.nih.gov/gene/?term=78792 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022250 78794 4930402H05Rik http://www.ncbi.nlm.nih.gov/gene/?term=78794 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022251 78796 Zcchc4 http://www.ncbi.nlm.nih.gov/gene/?term=78796 4930449I23Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022252 78797 Ndor1 http://www.ncbi.nlm.nih.gov/gene/?term=78797 "4930447P04Rik, NR1, Ndor " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022253 78798 Eml4 http://www.ncbi.nlm.nih.gov/gene/?term=78798 "4930443C24Rik, AI644019 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022254 7879 RAB7A http://www.ncbi.nlm.nih.gov/gene/?term=7879 "PRO2706, RAB7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022255 7879 RAB7A http://www.ncbi.nlm.nih.gov/gene/?term=7879 "PRO2706, RAB7 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022256 7879 RAB7A http://www.ncbi.nlm.nih.gov/gene/?term=7879 "PRO2706, RAB7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022257 78816 Gmip http://www.ncbi.nlm.nih.gov/gene/?term=78816 5031419I10Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022258 78825 Desi2 http://www.ncbi.nlm.nih.gov/gene/?term=78825 "5830417C01Rik, DeSI-2, Fam152a, Pppde1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022259 78829 Tsc22d4 http://www.ncbi.nlm.nih.gov/gene/?term=78829 "0610009M14Rik, 1700023B23Rik, AI415410, Thg-1pit, Tilz2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022260 78829 Tsc22d4 http://www.ncbi.nlm.nih.gov/gene/?term=78829 "0610009M14Rik, 1700023B23Rik, AI415410, Thg-1pit, Tilz2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022261 78830 Slc25a12 http://www.ncbi.nlm.nih.gov/gene/?term=78830 "2610002D09Rik, AI839531, B230107K20Rik, BB129864 " lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022262 78832 Cacul1 http://www.ncbi.nlm.nih.gov/gene/?term=78832 "2700078E11Rik, 2810417M16Rik, 9830127L17Rik, AI450346, D130033C15Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022263 78833 Gins3 http://www.ncbi.nlm.nih.gov/gene/?term=78833 "2700085M18Rik, AI616142 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022264 7884 SLBP http://www.ncbi.nlm.nih.gov/gene/?term=7884 HBP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022265 7884 SLBP http://www.ncbi.nlm.nih.gov/gene/?term=7884 HBP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022266 7884 SLBP http://www.ncbi.nlm.nih.gov/gene/?term=7884 HBP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022267 78887 Sfi1 http://www.ncbi.nlm.nih.gov/gene/?term=78887 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022268 78887 Sfi1 http://www.ncbi.nlm.nih.gov/gene/?term=78887 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022269 78889 Wsb1 http://www.ncbi.nlm.nih.gov/gene/?term=78889 "1110056B13Rik, 2700038M07Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022270 78891 Scyl1 http://www.ncbi.nlm.nih.gov/gene/?term=78891 "2810011O19Rik, C85140, Ntkl, mdf, mfd, p105 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022271 78895 Pus7l http://www.ncbi.nlm.nih.gov/gene/?term=78895 3000003F02Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022272 78902 4833447P13Rik http://www.ncbi.nlm.nih.gov/gene/?term=78902 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022273 78908 Igsf3 http://www.ncbi.nlm.nih.gov/gene/?term=78908 "1700016K10Rik, 2810035F16Rik, 4833439O17Rik, mKIAA0466 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022274 78912 Sp2 http://www.ncbi.nlm.nih.gov/gene/?term=78912 "4930480I16Rik, mKIAA0048 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022275 78913 Ltn1 http://www.ncbi.nlm.nih.gov/gene/?term=78913 "4930528H02Rik, AV266914, C87237, Listerin, Rnf160, Zfp294 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022276 78926 Gas2l1 http://www.ncbi.nlm.nih.gov/gene/?term=78926 "4930500E24Rik, D0Jmb1, Gar22, TU-71.1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022277 78937 Avl9 http://www.ncbi.nlm.nih.gov/gene/?term=78937 "5830411G16Rik, D730049P16Rik, mKIAA0241 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022278 78943 Ern1 http://www.ncbi.nlm.nih.gov/gene/?term=78943 "9030414B18Rik, AI225830, C85377, Ire1a, Ire1alpha, Ire1p " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022279 78943 Ern1 http://www.ncbi.nlm.nih.gov/gene/?term=78943 "9030414B18Rik, AI225830, C85377, Ire1a, Ire1alpha, Ire1p " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022280 78988 MRPL57 http://www.ncbi.nlm.nih.gov/gene/?term=78988 "MRP63, bMRP63 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022281 78991 PCYOX1L http://www.ncbi.nlm.nih.gov/gene/?term=78991 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022282 78992 YIPF2 http://www.ncbi.nlm.nih.gov/gene/?term=78992 FinGER2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022283 78994 PRR14 http://www.ncbi.nlm.nih.gov/gene/?term=78994 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022284 78996 C7orf49 http://www.ncbi.nlm.nih.gov/gene/?term=78996 MRI mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022285 78996 C7orf49 http://www.ncbi.nlm.nih.gov/gene/?term=78996 MRI mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022286 78999 LRFN4 http://www.ncbi.nlm.nih.gov/gene/?term=78999 "FIGLER6, SALM3, SALM3. " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022287 79000 AUNIP http://www.ncbi.nlm.nih.gov/gene/?term=79000 "AIBP, C1orf135 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022288 79000 AUNIP http://www.ncbi.nlm.nih.gov/gene/?term=79000 "AIBP, C1orf135 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022289 79001 VKORC1 http://www.ncbi.nlm.nih.gov/gene/?term=79001 "EDTP308, MST134, MST576, VKCFD2, VKOR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022290 79001 VKORC1 http://www.ncbi.nlm.nih.gov/gene/?term=79001 "EDTP308, MST134, MST576, VKCFD2, VKOR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022291 79002 C19orf43 http://www.ncbi.nlm.nih.gov/gene/?term=79002 fSAP18 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022292 79004 CUEDC2 http://www.ncbi.nlm.nih.gov/gene/?term=79004 "C10orf66, bA18I14.5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022293 79004 CUEDC2 http://www.ncbi.nlm.nih.gov/gene/?term=79004 "C10orf66, bA18I14.5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022294 79004 CUEDC2 http://www.ncbi.nlm.nih.gov/gene/?term=79004 "C10orf66, bA18I14.5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022295 79005 SCNM1 http://www.ncbi.nlm.nih.gov/gene/?term=79005 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022296 79006 METRN http://www.ncbi.nlm.nih.gov/gene/?term=79006 "C16orf23, c380A1.2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022297 79007 DBNDD1 http://www.ncbi.nlm.nih.gov/gene/?term=79007 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022298 79007 DBNDD1 http://www.ncbi.nlm.nih.gov/gene/?term=79007 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022299 79012 CAMKV http://www.ncbi.nlm.nih.gov/gene/?term=79012 "1G5, VACAMKL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022300 79016 DDA1 http://www.ncbi.nlm.nih.gov/gene/?term=79016 "C19orf58, PCIA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022301 79017 GGCT http://www.ncbi.nlm.nih.gov/gene/?term=79017 "C7orf24, CRF21, GCTG, GGC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022302 79019 CENPM http://www.ncbi.nlm.nih.gov/gene/?term=79019 "C22orf18, CENP-M, PANE1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022303 79019 CENPM http://www.ncbi.nlm.nih.gov/gene/?term=79019 "C22orf18, CENP-M, PANE1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022304 79019 CENPM http://www.ncbi.nlm.nih.gov/gene/?term=79019 "C22orf18, CENP-M, PANE1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022305 79022 TMEM106C http://www.ncbi.nlm.nih.gov/gene/?term=79022 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022306 79022 TMEM106C http://www.ncbi.nlm.nih.gov/gene/?term=79022 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022307 79022 TMEM106C http://www.ncbi.nlm.nih.gov/gene/?term=79022 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022308 79023 NUP37 http://www.ncbi.nlm.nih.gov/gene/?term=79023 p37 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022309 79023 NUP37 http://www.ncbi.nlm.nih.gov/gene/?term=79023 p37 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022310 79026 AHNAK http://www.ncbi.nlm.nih.gov/gene/?term=79026 AHNAKRS mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022311 79026 AHNAK http://www.ncbi.nlm.nih.gov/gene/?term=79026 AHNAKRS mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022312 79027 ZNF655 http://www.ncbi.nlm.nih.gov/gene/?term=79027 "VIK, VIK-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022313 79033 ERI3 http://www.ncbi.nlm.nih.gov/gene/?term=79033 "PINT1, PRNPIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022314 79033 ERI3 http://www.ncbi.nlm.nih.gov/gene/?term=79033 "PINT1, PRNPIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022315 79035 NABP2 http://www.ncbi.nlm.nih.gov/gene/?term=79035 "OBFC2B, SOSS-B1, SSB1, hSSB1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022316 79036 KXD1 http://www.ncbi.nlm.nih.gov/gene/?term=79036 "BORCS4, C19orf50, KXDL, MST096, MSTP096 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022317 79038 ZFYVE21 http://www.ncbi.nlm.nih.gov/gene/?term=79038 "HCVP7TP1, ZF21 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022318 79039 DDX54 http://www.ncbi.nlm.nih.gov/gene/?term=79039 DP97 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022319 79039 DDX54 http://www.ncbi.nlm.nih.gov/gene/?term=79039 DP97 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022320 7903 ST8SIA4 http://www.ncbi.nlm.nih.gov/gene/?term=7903 "PST, PST1, SIAT8D, ST8SIA-IV " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022321 7903 ST8SIA4 http://www.ncbi.nlm.nih.gov/gene/?term=7903 "PST, PST1, SIAT8D, ST8SIA-IV " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022322 79041 TMEM38A http://www.ncbi.nlm.nih.gov/gene/?term=79041 "TRIC-A, TRICA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022323 79042 TSEN34 http://www.ncbi.nlm.nih.gov/gene/?term=79042 "LENG5, PCH2C, SEN34, SEN34L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022324 79042 TSEN34 http://www.ncbi.nlm.nih.gov/gene/?term=79042 "LENG5, PCH2C, SEN34, SEN34L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022325 79043 Spsb3 http://www.ncbi.nlm.nih.gov/gene/?term=79043 "2310012N15Rik, 3300001M01Rik, SSB3, Tce1, mKIAA4204 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022326 79047 KCTD15 http://www.ncbi.nlm.nih.gov/gene/?term=79047 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022327 79048 SECISBP2 http://www.ncbi.nlm.nih.gov/gene/?term=79048 SBP2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022328 79050 NOC4L http://www.ncbi.nlm.nih.gov/gene/?term=79050 "NET49, NOC4, UTP19 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022329 79053 ALG8 http://www.ncbi.nlm.nih.gov/gene/?term=79053 CDG1H mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022330 79053 ALG8 http://www.ncbi.nlm.nih.gov/gene/?term=79053 CDG1H mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022331 79053 ALG8 http://www.ncbi.nlm.nih.gov/gene/?term=79053 CDG1H mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022332 79056 PRRG4 http://www.ncbi.nlm.nih.gov/gene/?term=79056 "PRGP4, TMG4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022333 79058 ASPSCR1 http://www.ncbi.nlm.nih.gov/gene/?term=79058 "ASPCR1, ASPL, ASPS, RCC17, TUG, UBXD9, UBXN9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022334 79058 ASPSCR1 http://www.ncbi.nlm.nih.gov/gene/?term=79058 "ASPCR1, ASPL, ASPS, RCC17, TUG, UBXD9, UBXN9 " lncRNA Homo sapiens 25630241 Nucleus Hela cell qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00022335 7905 REEP5 http://www.ncbi.nlm.nih.gov/gene/?term=7905 "C5orf18, D5S346, DP1, TB2, YOP1, Yip2e " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022336 7905 REEP5 http://www.ncbi.nlm.nih.gov/gene/?term=7905 "C5orf18, D5S346, DP1, TB2, YOP1, Yip2e " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022337 79064 TMEM223 http://www.ncbi.nlm.nih.gov/gene/?term=79064 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022338 79065 ATG9A http://www.ncbi.nlm.nih.gov/gene/?term=79065 "APG9L1, MGD3208, mATG9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022339 79065 ATG9A http://www.ncbi.nlm.nih.gov/gene/?term=79065 "APG9L1, MGD3208, mATG9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022340 79066 METTL16 http://www.ncbi.nlm.nih.gov/gene/?term=79066 METT10D mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022341 79068 FTO http://www.ncbi.nlm.nih.gov/gene/?term=79068 "ALKBH9, BMIQ14, GDFD " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022342 79068 FTO http://www.ncbi.nlm.nih.gov/gene/?term=79068 "ALKBH9, BMIQ14, GDFD " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022343 79070 KDELC1 http://www.ncbi.nlm.nih.gov/gene/?term=79070 "EP58, ERp58, KDEL1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022344 79070 KDELC1 http://www.ncbi.nlm.nih.gov/gene/?term=79070 "EP58, ERp58, KDEL1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022345 79071 ELOVL6 http://www.ncbi.nlm.nih.gov/gene/?term=79071 "FACE, FAE, LCE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022346 79071 ELOVL6 http://www.ncbi.nlm.nih.gov/gene/?term=79071 "FACE, FAE, LCE " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022347 79072 FASTKD3 http://www.ncbi.nlm.nih.gov/gene/?term=79072 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022348 79073 TMEM109 http://www.ncbi.nlm.nih.gov/gene/?term=79073 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022349 79074 C2orf49 http://www.ncbi.nlm.nih.gov/gene/?term=79074 asw mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022350 79075 DSCC1 http://www.ncbi.nlm.nih.gov/gene/?term=79075 DCC1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022351 79077 DCTPP1 http://www.ncbi.nlm.nih.gov/gene/?term=79077 "CDA03, RS21C6, XTP3TPA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022352 79077 DCTPP1 http://www.ncbi.nlm.nih.gov/gene/?term=79077 "CDA03, RS21C6, XTP3TPA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022353 79078 C1orf50 http://www.ncbi.nlm.nih.gov/gene/?term=79078 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022354 79080 CCDC86 http://www.ncbi.nlm.nih.gov/gene/?term=79080 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022355 79080 CCDC86 http://www.ncbi.nlm.nih.gov/gene/?term=79080 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022356 79081 LBHD1 http://www.ncbi.nlm.nih.gov/gene/?term=79081 C11orf48 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022357 79084 WDR77 http://www.ncbi.nlm.nih.gov/gene/?term=79084 "HKMT1069, MEP-50, MEP50, Nbla10071, p44, p44/Mep50 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022358 79085 SLC25A23 http://www.ncbi.nlm.nih.gov/gene/?term=79085 "APC2, MCSC2, SCaMC-3 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022359 79086 SMIM7 http://www.ncbi.nlm.nih.gov/gene/?term=79086 C19orf42 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022360 79086 SMIM7 http://www.ncbi.nlm.nih.gov/gene/?term=79086 C19orf42 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022361 79087 ALG12 http://www.ncbi.nlm.nih.gov/gene/?term=79087 "CDG1G, ECM39, PP14673, hALG12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022362 79089 TMUB2 http://www.ncbi.nlm.nih.gov/gene/?term=79089 FP2653 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022363 79090 TRAPPC6A http://www.ncbi.nlm.nih.gov/gene/?term=79090 TRS33 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022364 79091 METTL22 http://www.ncbi.nlm.nih.gov/gene/?term=79091 C16orf68 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022365 790955 UQCC3 http://www.ncbi.nlm.nih.gov/gene/?term=790955 "C11orf83, CCDS41658.1, MC3DN9, UNQ655 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022366 790955 UQCC3 http://www.ncbi.nlm.nih.gov/gene/?term=790955 "C11orf83, CCDS41658.1, MC3DN9, UNQ655 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022367 79095 C9orf16 http://www.ncbi.nlm.nih.gov/gene/?term=79095 EST00098 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022368 790 CAD http://www.ncbi.nlm.nih.gov/gene/?term=790 CDG1Z mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00022369 790 CAD http://www.ncbi.nlm.nih.gov/gene/?term=790 CDG1Z mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022370 790 CAD http://www.ncbi.nlm.nih.gov/gene/?term=790 CDG1Z mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022371 790 CAD http://www.ncbi.nlm.nih.gov/gene/?term=790 CDG1Z mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022372 79101 TAF1D http://www.ncbi.nlm.nih.gov/gene/?term=79101 "JOSD3, RAFI41, TAF(I)41, TAFI41 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022373 79101 TAF1D http://www.ncbi.nlm.nih.gov/gene/?term=79101 "JOSD3, RAFI41, TAF(I)41, TAFI41 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022374 79109 MAPKAP1 http://www.ncbi.nlm.nih.gov/gene/?term=79109 "JC310, MIP1, SIN1, SIN1b, SIN1g " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022375 791315 Gm9875 http://www.ncbi.nlm.nih.gov/gene/?term=791315 ENSMUSG00000052389 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022376 79132 DHX58 http://www.ncbi.nlm.nih.gov/gene/?term=79132 "D11LGP2, D11lgp2e, LGP2, RLR-3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022377 791331 BC005705 http://www.ncbi.nlm.nih.gov/gene/?term=791331 ENSMUSG00000042973 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022378 79133 NDUFAF5 http://www.ncbi.nlm.nih.gov/gene/?term=79133 "C20orf7, bA526K24.2, dJ842G6.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022379 791342 Gm10097 http://www.ncbi.nlm.nih.gov/gene/?term=791342 ENSMUSG00000061261 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022380 79134 TMEM185B http://www.ncbi.nlm.nih.gov/gene/?term=79134 FAM11B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022381 79134 TMEM185B http://www.ncbi.nlm.nih.gov/gene/?term=79134 FAM11B mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022382 79135 APOO http://www.ncbi.nlm.nih.gov/gene/?term=79135 "FAM121B, MIC26, Mic23, My025 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022383 79135 APOO http://www.ncbi.nlm.nih.gov/gene/?term=79135 "FAM121B, MIC26, Mic23, My025 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022384 79137 FAM134A http://www.ncbi.nlm.nih.gov/gene/?term=79137 "C2orf17, MAG-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022385 79137 FAM134A http://www.ncbi.nlm.nih.gov/gene/?term=79137 "C2orf17, MAG-2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022386 79137 FAM134A http://www.ncbi.nlm.nih.gov/gene/?term=79137 "C2orf17, MAG-2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022387 79137 FAM134A http://www.ncbi.nlm.nih.gov/gene/?term=79137 C2orf17 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022388 79139 DERL1 http://www.ncbi.nlm.nih.gov/gene/?term=79139 "DER-1, DER1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022389 79139 DERL1 http://www.ncbi.nlm.nih.gov/gene/?term=79139 "DER-1, DER1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022390 79139 DERL1 http://www.ncbi.nlm.nih.gov/gene/?term=79139 "DER-1, DER1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022391 7913 DEK http://www.ncbi.nlm.nih.gov/gene/?term=7913 D6S231E mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022392 79140 CCDC28B http://www.ncbi.nlm.nih.gov/gene/?term=79140 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022393 79142 PHF23 http://www.ncbi.nlm.nih.gov/gene/?term=79142 hJUNE-1b mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022394 79143 MBOAT7 http://www.ncbi.nlm.nih.gov/gene/?term=79143 "BB1, LENG4, LPIAT, LRC4, MBOA7, OACT7, hMBOA-7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022395 79143 MBOAT7 http://www.ncbi.nlm.nih.gov/gene/?term=79143 "BB1, LENG4, LPIAT, LRC4, MBOA7, OACT7, hMBOA-7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022396 79144 PPDPF http://www.ncbi.nlm.nih.gov/gene/?term=79144 "C20orf149, dJ697K14.9, exdpf " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022397 79145 CHCHD7 http://www.ncbi.nlm.nih.gov/gene/?term=79145 COX23 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022398 79145 CHCHD7 http://www.ncbi.nlm.nih.gov/gene/?term=79145 COX23 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022399 79147 FKRP http://www.ncbi.nlm.nih.gov/gene/?term=79147 "LGMD2I, MDC1C, MDDGA5, MDDGB5, MDDGC5 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022400 79147 FKRP http://www.ncbi.nlm.nih.gov/gene/?term=79147 "LGMD2I, MDC1C, MDDGA5, MDDGB5, MDDGC5 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022401 79147 FKRP http://www.ncbi.nlm.nih.gov/gene/?term=79147 "LGMD2I, MDC1C, MDDGA5, MDDGB5, MDDGC5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022402 79153 GDPD3 http://www.ncbi.nlm.nih.gov/gene/?term=79153 GDE7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022403 79154 DHRS11 http://www.ncbi.nlm.nih.gov/gene/?term=79154 "ARPG836, SDR24C1, spDHRS11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022404 79155 TNIP2 http://www.ncbi.nlm.nih.gov/gene/?term=79155 "ABIN2, FLIP1, KLIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022405 79156 PLEKHF1 http://www.ncbi.nlm.nih.gov/gene/?term=79156 "APPD, LAPF, PHAFIN1, ZFYVE15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022406 79157 MFSD11 http://www.ncbi.nlm.nih.gov/gene/?term=79157 ET mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022407 79158 GNPTAB http://www.ncbi.nlm.nih.gov/gene/?term=79158 "GNPTA, ICD " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022408 79158 GNPTAB http://www.ncbi.nlm.nih.gov/gene/?term=79158 "GNPTA, ICD " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022409 79158 GNPTAB http://www.ncbi.nlm.nih.gov/gene/?term=79158 "GNPTA, ICD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022410 79159 NOL12 http://www.ncbi.nlm.nih.gov/gene/?term=79159 "Nop25, dJ37E16.7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022411 7915 ALDH5A1 http://www.ncbi.nlm.nih.gov/gene/?term=7915 "SSADH, SSDH " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022412 7915 ALDH5A1 http://www.ncbi.nlm.nih.gov/gene/?term=7915 "SSADH, SSDH " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022413 7915 ALDH5A1 http://www.ncbi.nlm.nih.gov/gene/?term=7915 "SSADH, SSDH " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022414 79161 TMEM243 http://www.ncbi.nlm.nih.gov/gene/?term=79161 "C7orf23, MM-TRAG " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022415 79161 TMEM243 http://www.ncbi.nlm.nih.gov/gene/?term=79161 "C7orf23, MM-TRAG " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022416 79169 C1orf35 http://www.ncbi.nlm.nih.gov/gene/?term=79169 MMTAG2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022417 79169 C1orf35 http://www.ncbi.nlm.nih.gov/gene/?term=79169 MMTAG2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022418 7916 PRRC2A http://www.ncbi.nlm.nih.gov/gene/?term=7916 "BAT2, D6S51, D6S51E, G2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022419 79170 PRR15L http://www.ncbi.nlm.nih.gov/gene/?term=79170 ATAD4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022420 79171 RBM42 http://www.ncbi.nlm.nih.gov/gene/?term=79171 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022421 79171 RBM42 http://www.ncbi.nlm.nih.gov/gene/?term=79171 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022422 79172 CENPO http://www.ncbi.nlm.nih.gov/gene/?term=79172 "CENP-O, ICEN-36, MCM21R " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022423 79172 CENPO http://www.ncbi.nlm.nih.gov/gene/?term=79172 "CENP-O, ICEN-36, MCM21R " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022424 79173 C19orf57 http://www.ncbi.nlm.nih.gov/gene/?term=79173 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022425 79174 CRELD2 http://www.ncbi.nlm.nih.gov/gene/?term=79174 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022426 79174 CRELD2 http://www.ncbi.nlm.nih.gov/gene/?term=79174 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022427 79176 FBXL15 http://www.ncbi.nlm.nih.gov/gene/?term=79176 "FBXO37, Fbl15, JET, PSD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022428 79176 FBXL15 http://www.ncbi.nlm.nih.gov/gene/?term=79176 "FBXO37, Fbl15, JET, PSD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022429 79177 ZNF576 http://www.ncbi.nlm.nih.gov/gene/?term=79177 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022430 79177 ZNF576 http://www.ncbi.nlm.nih.gov/gene/?term=79177 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022431 79178 THTPA http://www.ncbi.nlm.nih.gov/gene/?term=79178 "THTP, THTPASE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022432 7917 BAG6 http://www.ncbi.nlm.nih.gov/gene/?term=7917 "BAG-6, BAT3, D6S52E, G3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022433 79180 EFHD2 http://www.ncbi.nlm.nih.gov/gene/?term=79180 SWS1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022434 79183 TTPAL http://www.ncbi.nlm.nih.gov/gene/?term=79183 C20orf121 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022435 79183 TTPAL http://www.ncbi.nlm.nih.gov/gene/?term=79183 C20orf121 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022436 79184 BRCC3 http://www.ncbi.nlm.nih.gov/gene/?term=79184 "BRCC36, C6.1A, CXorf53 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022437 79188 TMEM43 http://www.ncbi.nlm.nih.gov/gene/?term=79188 "ARVC5, ARVD5, EDMD7, LUMA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022438 7918 GPANK1 http://www.ncbi.nlm.nih.gov/gene/?term=7918 "ANKRD59, BAT4, D6S54E, G5, GPATCH10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022439 79191 IRX3 http://www.ncbi.nlm.nih.gov/gene/?term=79191 "IRX-1, IRXB1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022440 7919 DDX39B http://www.ncbi.nlm.nih.gov/gene/?term=7919 "BAT1, D6S81E, UAP56 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022441 79202 Tnfrsf22 http://www.ncbi.nlm.nih.gov/gene/?term=79202 "2810028K06Rik, C130035G06Rik, SOBa, Tnfrh2, Tnfrsf1al2, mDcTrailr2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022442 79228 THOC6 http://www.ncbi.nlm.nih.gov/gene/?term=79228 "BBIS, WDR58, fSAP35 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022443 7922 SLC39A7 http://www.ncbi.nlm.nih.gov/gene/?term=7922 "D6S115E, D6S2244E, H2-KE4, HKE4, KE4, RING5, ZIP7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022444 79230 ZNF557 http://www.ncbi.nlm.nih.gov/gene/?term=79230 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022445 7923 HSD17B8 http://www.ncbi.nlm.nih.gov/gene/?term=7923 "D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022446 7923 HSD17B8 http://www.ncbi.nlm.nih.gov/gene/?term=7923 "D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022447 79263 Trim39 http://www.ncbi.nlm.nih.gov/gene/?term=79263 "1100001D15Rik, E130103K13Rik, RBCC-B30.2, Rnf23, mKIAA4179, tfp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022448 79264 Krit1 http://www.ncbi.nlm.nih.gov/gene/?term=79264 "2010007K12Rik, A630036P20Rik, AA432855, AI450393, AI643869, BB155247, BB235701, Ccm1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022449 79269 DCAF10 http://www.ncbi.nlm.nih.gov/gene/?term=79269 WDR32 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022450 79269 DCAF10 http://www.ncbi.nlm.nih.gov/gene/?term=79269 WDR32 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022451 79364 ZXDC http://www.ncbi.nlm.nih.gov/gene/?term=79364 ZXDL mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022452 79364 ZXDC http://www.ncbi.nlm.nih.gov/gene/?term=79364 ZXDL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022453 7936 NELFE http://www.ncbi.nlm.nih.gov/gene/?term=7936 "D6S45, NELF-E, RD, RDBP, RDP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022454 7936 NELFE http://www.ncbi.nlm.nih.gov/gene/?term=7936 "D6S45, NELF-E, RD, RDBP, RDP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022455 793 CALB1 http://www.ncbi.nlm.nih.gov/gene/?term=793 "CALB, D-28K " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022456 79401 Spz1 http://www.ncbi.nlm.nih.gov/gene/?term=79401 "1700027M20Rik, AI429130 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022457 7940 LST1 http://www.ncbi.nlm.nih.gov/gene/?term=7940 "B144, D6S49E, LST-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022458 79441 HAUS3 http://www.ncbi.nlm.nih.gov/gene/?term=79441 "C4orf15, IT1, dgt3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022459 79441 HAUS3 http://www.ncbi.nlm.nih.gov/gene/?term=79441 "C4orf15, IT1, dgt3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022460 79441 HAUS3 http://www.ncbi.nlm.nih.gov/gene/?term=79441 "C4orf15, IT1, dgt3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022461 79443 FYCO1 http://www.ncbi.nlm.nih.gov/gene/?term=79443 "CATC2, CTRCT18, RUFY3, ZFYVE7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022462 79447 PAGR1 http://www.ncbi.nlm.nih.gov/gene/?term=79447 "C16orf53, GAS, PA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022463 79455 Pdcl2 http://www.ncbi.nlm.nih.gov/gene/?term=79455 "1700010B22Rik, 1700016K07Rik, Mgcphlp, Tphlp " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022464 79464 Lias http://www.ncbi.nlm.nih.gov/gene/?term=79464 "2900022L22Rik, 4933425M12Rik, 7a5ex, C77512, LS, lip-syn " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022465 79469 DLEU2L http://www.ncbi.nlm.nih.gov/gene/?term=79469 BCMSUNL lncRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00022466 794 CALB2 http://www.ncbi.nlm.nih.gov/gene/?term=794 "CAB29, CAL2, CR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022467 79555 BC005537 http://www.ncbi.nlm.nih.gov/gene/?term=79555 "8030460C05Rik, C78201 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022468 79566 Sh3bp5l http://www.ncbi.nlm.nih.gov/gene/?term=79566 "2310074E09Rik, BC003251, mKIAA1720 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022469 79567 FAM65A http://www.ncbi.nlm.nih.gov/gene/?term=79567 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022470 79568 C2orf47 http://www.ncbi.nlm.nih.gov/gene/?term=79568 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022471 79571 GCC1 http://www.ncbi.nlm.nih.gov/gene/?term=79571 "GCC1P, GCC88 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022472 79571 GCC1 http://www.ncbi.nlm.nih.gov/gene/?term=79571 "GCC1P, GCC88 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022473 79572 ATP13A3 http://www.ncbi.nlm.nih.gov/gene/?term=79572 AFURS1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022474 79572 ATP13A3 http://www.ncbi.nlm.nih.gov/gene/?term=79572 AFURS1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022475 79574 EPS8L3 http://www.ncbi.nlm.nih.gov/gene/?term=79574 EPS8R3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022476 79577 CDC73 http://www.ncbi.nlm.nih.gov/gene/?term=79577 "C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022477 79577 CDC73 http://www.ncbi.nlm.nih.gov/gene/?term=79577 "C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022478 79581 SLC52A2 http://www.ncbi.nlm.nih.gov/gene/?term=79581 "BVVLS2, D15Ertd747e, GPCR41, GPR172A, PAR1, RFT3, RFVT2, hRFT3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022479 79582 SPAG16 http://www.ncbi.nlm.nih.gov/gene/?term=79582 "PF20, WDR29 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022480 79582 SPAG16 http://www.ncbi.nlm.nih.gov/gene/?term=79582 "PF20, WDR29 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022481 79583 TMEM231 http://www.ncbi.nlm.nih.gov/gene/?term=79583 "ALYE870, JBTS20, MKS11, PRO1886 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022482 79585 CORO7 http://www.ncbi.nlm.nih.gov/gene/?term=79585 "0610011B16Rik, CRN7, POD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022483 79586 CHPF http://www.ncbi.nlm.nih.gov/gene/?term=79586 "CHSY2, CSS2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022484 79587 CARS2 http://www.ncbi.nlm.nih.gov/gene/?term=79587 "COXPD27, cysRS " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022485 79590 MRPL24 http://www.ncbi.nlm.nih.gov/gene/?term=79590 "L24mt, MRP-L18, MRP-L24 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022486 79591 C10orf76 http://www.ncbi.nlm.nih.gov/gene/?term=79591 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022487 79591 C10orf76 http://www.ncbi.nlm.nih.gov/gene/?term=79591 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022488 79594 MUL1 http://www.ncbi.nlm.nih.gov/gene/?term=79594 "C1orf166, GIDE, MAPL, MULAN, RNF218 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022489 79594 MUL1 http://www.ncbi.nlm.nih.gov/gene/?term=79594 "C1orf166, GIDE, MAPL, MULAN, RNF218 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022490 79595 SAP130 http://www.ncbi.nlm.nih.gov/gene/?term=79595 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022491 79596 RNF219 http://www.ncbi.nlm.nih.gov/gene/?term=79596 C13orf7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022492 79598 CEP97 http://www.ncbi.nlm.nih.gov/gene/?term=79598 "2810403B08Rik, LRRIQ2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022493 79607 FAM118B http://www.ncbi.nlm.nih.gov/gene/?term=79607 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022494 79609 VCPKMT http://www.ncbi.nlm.nih.gov/gene/?term=79609 "C14orf138, METTL21D, VCP-KMT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022495 79613 TANGO6 http://www.ncbi.nlm.nih.gov/gene/?term=79613 TMCO7 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022496 79613 TANGO6 http://www.ncbi.nlm.nih.gov/gene/?term=79613 TMCO7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022497 79616 CCNJL http://www.ncbi.nlm.nih.gov/gene/?term=79616 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022498 79621 RNASEH2B http://www.ncbi.nlm.nih.gov/gene/?term=79621 "AGS2, DLEU8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022499 79622 SNRNP25 http://www.ncbi.nlm.nih.gov/gene/?term=79622 C16orf33 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022500 79622 SNRNP25 http://www.ncbi.nlm.nih.gov/gene/?term=79622 C16orf33 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022501 79624 ARMT1 http://www.ncbi.nlm.nih.gov/gene/?term=79624 C6orf211 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022502 79624 ARMT1 http://www.ncbi.nlm.nih.gov/gene/?term=79624 C6orf211 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022503 79626 TNFAIP8L2 http://www.ncbi.nlm.nih.gov/gene/?term=79626 TIPE2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022504 79628 SH3TC2 http://www.ncbi.nlm.nih.gov/gene/?term=79628 "CMT4C, MNMN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022505 79628 SH3TC2 http://www.ncbi.nlm.nih.gov/gene/?term=79628 "CMT4C, MNMN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022506 79633 FAT4 http://www.ncbi.nlm.nih.gov/gene/?term=79633 "CDHF14, CDHR11, FAT-J, FATJ, HKLLS2, NBLA00548, VMLDS2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022507 79637 ARMC7 http://www.ncbi.nlm.nih.gov/gene/?term=79637 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022508 79639 TMEM53 http://www.ncbi.nlm.nih.gov/gene/?term=79639 NET4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022509 79640 C22orf46 http://www.ncbi.nlm.nih.gov/gene/?term=79640 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022510 79641 ROGDI http://www.ncbi.nlm.nih.gov/gene/?term=79641 KTZS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022511 79643 CHMP6 http://www.ncbi.nlm.nih.gov/gene/?term=79643 VPS20 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022512 79644 SRD5A3 http://www.ncbi.nlm.nih.gov/gene/?term=79644 "CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022513 79644 SRD5A3 http://www.ncbi.nlm.nih.gov/gene/?term=79644 "CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022514 79646 PANK3 http://www.ncbi.nlm.nih.gov/gene/?term=79646 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022515 79646 PANK3 http://www.ncbi.nlm.nih.gov/gene/?term=79646 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022516 79647 AKIRIN1 http://www.ncbi.nlm.nih.gov/gene/?term=79647 "C1orf108, STRF2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022517 79647 AKIRIN1 http://www.ncbi.nlm.nih.gov/gene/?term=79647 "C1orf108, STRF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022518 79648 MCPH1 http://www.ncbi.nlm.nih.gov/gene/?term=79648 "BRIT1, MCT " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022519 79648 MCPH1 http://www.ncbi.nlm.nih.gov/gene/?term=79648 "BRIT1, MCT " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022520 79648 MCPH1 http://www.ncbi.nlm.nih.gov/gene/?term=79648 "BRIT1, MCT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022521 79649 MAP7D3 http://www.ncbi.nlm.nih.gov/gene/?term=79649 MDP3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022522 79650 USB1 http://www.ncbi.nlm.nih.gov/gene/?term=79650 "C16orf57, HVSL1, Mpn1, PN, hUsb1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022523 79654 HECTD3 http://www.ncbi.nlm.nih.gov/gene/?term=79654 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022524 79656 BEND5 http://www.ncbi.nlm.nih.gov/gene/?term=79656 C1orf165 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022525 7965 AIMP2 http://www.ncbi.nlm.nih.gov/gene/?term=7965 "JTV-1, JTV1, P38, PRO0992 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022526 7965 AIMP2 http://www.ncbi.nlm.nih.gov/gene/?term=7965 "JTV-1, JTV1, P38, PRO0992 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022527 79660 PPP1R3B http://www.ncbi.nlm.nih.gov/gene/?term=79660 "GL, PPP1R4, PTG " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022528 79660 PPP1R3B http://www.ncbi.nlm.nih.gov/gene/?term=79660 "GL, PPP1R4, PTG " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022529 79660 PPP1R3B http://www.ncbi.nlm.nih.gov/gene/?term=79660 "GL, PPP1R4, PTG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022530 79664 ICE2 http://www.ncbi.nlm.nih.gov/gene/?term=79664 "BRCC1, NARG2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022531 79664 ICE2 http://www.ncbi.nlm.nih.gov/gene/?term=79664 "BRCC1, NARG2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022532 79664 ICE2 http://www.ncbi.nlm.nih.gov/gene/?term=79664 "BRCC1, NARG2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022533 79664 ICE2 http://www.ncbi.nlm.nih.gov/gene/?term=79664 "BRCC1, NARG2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022534 79665 DHX40 http://www.ncbi.nlm.nih.gov/gene/?term=79665 "ARG147, DDX40, PAD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022535 79665 DHX40 http://www.ncbi.nlm.nih.gov/gene/?term=79665 "ARG147, DDX40, PAD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022536 79666 PLEKHF2 http://www.ncbi.nlm.nih.gov/gene/?term=79666 "EAPF, PHAFIN2, ZFYVE18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022537 79669 C3orf52 http://www.ncbi.nlm.nih.gov/gene/?term=79669 TTMP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022538 79670 ZCCHC6 http://www.ncbi.nlm.nih.gov/gene/?term=79670 "PAPD6, TUT7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022539 79672 FN3KRP http://www.ncbi.nlm.nih.gov/gene/?term=79672 FN3KL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022540 79672 FN3KRP http://www.ncbi.nlm.nih.gov/gene/?term=79672 FN3KL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022541 79673 ZNF329 http://www.ncbi.nlm.nih.gov/gene/?term=79673 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022542 79673 ZNF329 http://www.ncbi.nlm.nih.gov/gene/?term=79673 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022543 79674 VEPH1 http://www.ncbi.nlm.nih.gov/gene/?term=79674 "MELT, VEPH " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022544 79675 FASTKD1 http://www.ncbi.nlm.nih.gov/gene/?term=79675 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022545 79676 OGFOD2 http://www.ncbi.nlm.nih.gov/gene/?term=79676 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022546 79677 SMC6 http://www.ncbi.nlm.nih.gov/gene/?term=79677 "SMC-6L1, hSMC6, SMC6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022547 79680 C22orf29 http://www.ncbi.nlm.nih.gov/gene/?term=79680 BOP mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022548 79682 CENPU http://www.ncbi.nlm.nih.gov/gene/?term=79682 "CENP5050, KLIP1, MLF1IP, PBIP1, CENPU " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022549 79682 CENPU http://www.ncbi.nlm.nih.gov/gene/?term=79682 "CENP5050, KLIP1, MLF1IP, PBIP1, CENPU " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022550 79682 CENPU http://www.ncbi.nlm.nih.gov/gene/?term=79682 "CENP50, CENPU50, KLIP1, MLF1IP, PBIP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022551 79685 SAP30L http://www.ncbi.nlm.nih.gov/gene/?term=79685 NS4ATP2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022552 79689 STEAP4 http://www.ncbi.nlm.nih.gov/gene/?term=79689 "STAMP2, TIARP, TNFAIP9 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022553 79689 STEAP4 http://www.ncbi.nlm.nih.gov/gene/?term=79689 "STAMP2, TIARP, TNFAIP9 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022554 79690 GAL3ST4 http://www.ncbi.nlm.nih.gov/gene/?term=79690 GAL3ST-4 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022555 79690 GAL3ST4 http://www.ncbi.nlm.nih.gov/gene/?term=79690 GAL3ST-4 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022556 79691 QTRT2 http://www.ncbi.nlm.nih.gov/gene/?term=79691 QTRTD1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022557 79691 QTRT2 http://www.ncbi.nlm.nih.gov/gene/?term=79691 QTRTD1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022558 79691 QTRT2 http://www.ncbi.nlm.nih.gov/gene/?term=79691 QTRTD1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022559 79693 YRDC http://www.ncbi.nlm.nih.gov/gene/?term=79693 "DRIP3, IRIP, SUA5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022560 79693 YRDC http://www.ncbi.nlm.nih.gov/gene/?term=79693 "DRIP3, IRIP, SUA5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022561 79694 MANEA http://www.ncbi.nlm.nih.gov/gene/?term=79694 "ENDO, hEndo " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022562 79695 GALNT12 http://www.ncbi.nlm.nih.gov/gene/?term=79695 "CRCS1, GalNAc-T12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022563 79695 GALNT12 http://www.ncbi.nlm.nih.gov/gene/?term=79695 "CRCS1, GalNAc-T12 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022564 79697 C14orf169 http://www.ncbi.nlm.nih.gov/gene/?term=79697 "MAPJD, NO66, ROX, URLC2, hsNO66 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022565 79699 ZYG11B http://www.ncbi.nlm.nih.gov/gene/?term=79699 ZYG11 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022566 796 CALCA http://www.ncbi.nlm.nih.gov/gene/?term=796 "CALC1, CGRP, CGRP-I, CGRP1, CT, KC, PCT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022567 79701 OGFOD3 http://www.ncbi.nlm.nih.gov/gene/?term=79701 C17orf101 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022568 79701 OGFOD3 http://www.ncbi.nlm.nih.gov/gene/?term=79701 C17orf101 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022569 79703 C11orf80 http://www.ncbi.nlm.nih.gov/gene/?term=79703 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022570 79707 NOL9 http://www.ncbi.nlm.nih.gov/gene/?term=79707 "Grc3, NET6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022571 79707 NOL9 http://www.ncbi.nlm.nih.gov/gene/?term=79707 "Grc3, NET6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022572 79709 COLGALT1 http://www.ncbi.nlm.nih.gov/gene/?term=79709 GLT25D1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022573 79709 COLGALT1 http://www.ncbi.nlm.nih.gov/gene/?term=79709 GLT25D1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022574 79709 COLGALT1 http://www.ncbi.nlm.nih.gov/gene/?term=79709 GLT25D1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022575 79710 MORC4 http://www.ncbi.nlm.nih.gov/gene/?term=79710 "ZCW4, ZCWCC2, dJ75H8.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022576 79710 MORC4 http://www.ncbi.nlm.nih.gov/gene/?term=79710 "ZCW4, ZCWCC2, dJ75H8.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022577 79714 CCDC51 http://www.ncbi.nlm.nih.gov/gene/?term=79714 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022578 79717 PPCS http://www.ncbi.nlm.nih.gov/gene/?term=79717 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022579 79718 TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/?term=79718 "C21, DC42, IRA1, TBLR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022580 79718 TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/?term=79718 "C21, DC42, IRA1, TBLR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022581 79719 AAGAB http://www.ncbi.nlm.nih.gov/gene/?term=79719 "KPPP1, PPKP1, PPKP1A, p34 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022582 79719 AAGAB http://www.ncbi.nlm.nih.gov/gene/?term=79719 "KPPP1, PPKP1, PPKP1A, p34 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022583 79722 ANKRD55 http://www.ncbi.nlm.nih.gov/gene/?term=79722 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022584 79723 SUV39H2 http://www.ncbi.nlm.nih.gov/gene/?term=79723 KMT1B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022585 79727 LIN28A http://www.ncbi.nlm.nih.gov/gene/?term=79727 "CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022586 79727 LIN28A http://www.ncbi.nlm.nih.gov/gene/?term=79727 "CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022587 79728 PALB2 http://www.ncbi.nlm.nih.gov/gene/?term=79728 "FANCN, PNCA3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022588 79731 NARS2 http://www.ncbi.nlm.nih.gov/gene/?term=79731 "DFNB94, SLM5, asnRS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022589 79733 E2F8 http://www.ncbi.nlm.nih.gov/gene/?term=79733 E2F-8 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022590 79734 KCTD17 http://www.ncbi.nlm.nih.gov/gene/?term=79734 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022591 79736 TEFM http://www.ncbi.nlm.nih.gov/gene/?term=79736 C17orf42 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022592 79741 CCDC7 http://www.ncbi.nlm.nih.gov/gene/?term=79741 "BIOT2, BioT2-A, BioT2-B, BioT2-C, C10orf68 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022593 79746 ECHDC3 http://www.ncbi.nlm.nih.gov/gene/?term=79746 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022594 79748 LMAN1L http://www.ncbi.nlm.nih.gov/gene/?term=79748 "ERGIC-53L, ERGL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022595 79751 SLC25A22 http://www.ncbi.nlm.nih.gov/gene/?term=79751 "EIEE3, GC-1, GC1, NET44 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022596 79751 SLC25A22 http://www.ncbi.nlm.nih.gov/gene/?term=79751 "EIEE3, GC1, NET44 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022597 79752 ZFAND1 http://www.ncbi.nlm.nih.gov/gene/?term=79752 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022598 79754 ASB13 http://www.ncbi.nlm.nih.gov/gene/?term=79754 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022599 79754 ASB13 http://www.ncbi.nlm.nih.gov/gene/?term=79754 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022600 79758 DHRS12 http://www.ncbi.nlm.nih.gov/gene/?term=79758 SDR40C1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022601 7975 MAFK http://www.ncbi.nlm.nih.gov/gene/?term=7975 "NFE2U, P18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022602 79760 GEMIN7 http://www.ncbi.nlm.nih.gov/gene/?term=79760 SIP3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022603 79762 C1orf115 http://www.ncbi.nlm.nih.gov/gene/?term=79762 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022604 79763 ISOC2 http://www.ncbi.nlm.nih.gov/gene/?term=79763 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022605 79767 ELMO3 http://www.ncbi.nlm.nih.gov/gene/?term=79767 "CED-12, CED12, ELMO-3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022606 79768 KATNBL1 http://www.ncbi.nlm.nih.gov/gene/?term=79768 C15orf29 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022607 7976 FZD3 http://www.ncbi.nlm.nih.gov/gene/?term=7976 Fz-3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022608 79770 TXNDC15 http://www.ncbi.nlm.nih.gov/gene/?term=79770 "C5orf14, UNQ335 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022609 79770 TXNDC15 http://www.ncbi.nlm.nih.gov/gene/?term=79770 "C5orf14, UNQ335 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022610 79770 TXNDC15 http://www.ncbi.nlm.nih.gov/gene/?term=79770 "C5orf14, UNQ335 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022611 79774 GRTP1 http://www.ncbi.nlm.nih.gov/gene/?term=79774 TBC1D6 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022612 79774 GRTP1 http://www.ncbi.nlm.nih.gov/gene/?term=79774 TBC1D6 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022613 79776 ZFHX4 http://www.ncbi.nlm.nih.gov/gene/?term=79776 "ZFH4, ZHF4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022614 79776 ZFHX4 http://www.ncbi.nlm.nih.gov/gene/?term=79776 "ZFH4, ZHF4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022615 79777 ACBD4 http://www.ncbi.nlm.nih.gov/gene/?term=79777 HMFT0700 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022616 79778 MICALL2 http://www.ncbi.nlm.nih.gov/gene/?term=79778 "JRAB, MICAL-L2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022617 79778 MICALL2 http://www.ncbi.nlm.nih.gov/gene/?term=79778 "JRAB, MICAL-L2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022618 79782 LRRC31 http://www.ncbi.nlm.nih.gov/gene/?term=79782 HEL-S-293 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022619 7978 MTERF1 http://www.ncbi.nlm.nih.gov/gene/?term=7978 MTERF mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022620 79791 FBXO31 http://www.ncbi.nlm.nih.gov/gene/?term=79791 "FBX14, FBXO14, Fbx31, MRT45, pp2386 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022621 79791 FBXO31 http://www.ncbi.nlm.nih.gov/gene/?term=79791 "FBX14, FBXO14, Fbx31, MRT45, pp2386 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022622 79792 GSDMD http://www.ncbi.nlm.nih.gov/gene/?term=79792 "DF5L, DFNA5L, FKSG10C1, GSDMD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022623 79794 C12orf49 http://www.ncbi.nlm.nih.gov/gene/?term=79794 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022624 79794 C12orf49 http://www.ncbi.nlm.nih.gov/gene/?term=79794 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022625 7979 SHFM1 http://www.ncbi.nlm.nih.gov/gene/?term=7979 "DSS1, ECD, SEM1, SHFD1, SHSF1, Shfdg1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022626 7979 SHFM1 http://www.ncbi.nlm.nih.gov/gene/?term=7979 "DSS1, ECD, SEM1, SHFD1, SHSF1, Shfdg1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022627 797 CALCB http://www.ncbi.nlm.nih.gov/gene/?term=797 "CALC2, CGRP-II, CGRP2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022628 79801 SHCBP1 http://www.ncbi.nlm.nih.gov/gene/?term=79801 PAL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022629 79803 HPS6 http://www.ncbi.nlm.nih.gov/gene/?term=79803 BLOC2S3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022630 79807 GSTCD http://www.ncbi.nlm.nih.gov/gene/?term=79807 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022631 79809 TTC21B http://www.ncbi.nlm.nih.gov/gene/?term=79809 "ATD4, IFT139, IFT139B, JBTS11, NPHP12, Nbla10696, SRTD4, THM1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022632 79809 TTC21B http://www.ncbi.nlm.nih.gov/gene/?term=79809 "ATD4, IFT139, IFT139B, JBTS11, NPHP12, Nbla10696, SRTD4, THM1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022633 7980 TFPI2 http://www.ncbi.nlm.nih.gov/gene/?term=7980 "PP5, REF1, TFPI-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022634 79811 SLTM http://www.ncbi.nlm.nih.gov/gene/?term=79811 Met mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022635 79814 AGMAT http://www.ncbi.nlm.nih.gov/gene/?term=79814 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022636 79817 MOB3B http://www.ncbi.nlm.nih.gov/gene/?term=79817 "C9orf35, MOB1D, MOBKL2B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022637 79817 MOB3B http://www.ncbi.nlm.nih.gov/gene/?term=79817 "C9orf35, MOB1D, MOBKL2B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022638 79818 ZNF552 http://www.ncbi.nlm.nih.gov/gene/?term=79818 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022639 79818 ZNF552 http://www.ncbi.nlm.nih.gov/gene/?term=79818 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022640 79818 ZNF552 http://www.ncbi.nlm.nih.gov/gene/?term=79818 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022641 79822 ARHGAP28 http://www.ncbi.nlm.nih.gov/gene/?term=79822 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022642 79828 METTL8 http://www.ncbi.nlm.nih.gov/gene/?term=79828 TIP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022643 79828 METTL8 http://www.ncbi.nlm.nih.gov/gene/?term=79828 TIP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022644 79828 METTL8 http://www.ncbi.nlm.nih.gov/gene/?term=79828 TIP mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022645 79828 METTL8 http://www.ncbi.nlm.nih.gov/gene/?term=79828 TIP mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022646 79828 METTL8 http://www.ncbi.nlm.nih.gov/gene/?term=79828 TIP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022647 79829 NAA40 http://www.ncbi.nlm.nih.gov/gene/?term=79829 "NAT11, PATT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022648 7982 ST7 http://www.ncbi.nlm.nih.gov/gene/?term=7982 "ETS7q, FAM4A, FAM4A1, HELG, RAY1, SEN4, TSG7 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022649 7982 ST7 http://www.ncbi.nlm.nih.gov/gene/?term=7982 "ETS7q, FAM4A, FAM4A1, HELG, RAY1, SEN4, TSG7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022650 79830 ZMYM1 http://www.ncbi.nlm.nih.gov/gene/?term=79830 MYM mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022651 79832 QSER1 http://www.ncbi.nlm.nih.gov/gene/?term=79832 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022652 79833 GEMIN6 http://www.ncbi.nlm.nih.gov/gene/?term=79833 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022653 79837 PIP4K2C http://www.ncbi.nlm.nih.gov/gene/?term=79837 PIP5K2C mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022654 79842 ZBTB3 http://www.ncbi.nlm.nih.gov/gene/?term=79842 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022655 79842 ZBTB3 http://www.ncbi.nlm.nih.gov/gene/?term=79842 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022656 79847 MFSD13A http://www.ncbi.nlm.nih.gov/gene/?term=79847 "C10orf77, TMEM180, bA18I14.8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022657 79847 MFSD13A http://www.ncbi.nlm.nih.gov/gene/?term=79847 "C10orf77, TMEM180, bA18I14.8 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022658 79848 CSPP1 http://www.ncbi.nlm.nih.gov/gene/?term=79848 "CSPP, JBTS21 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022659 79850 FAM57A http://www.ncbi.nlm.nih.gov/gene/?term=79850 CT120 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022660 79856 SNX22 http://www.ncbi.nlm.nih.gov/gene/?term=79856 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022661 79861 TUBAL3 http://www.ncbi.nlm.nih.gov/gene/?term=79861 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022662 79863 RBFA http://www.ncbi.nlm.nih.gov/gene/?term=79863 "C18orf22, HsT169 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022663 79865 TREML2 http://www.ncbi.nlm.nih.gov/gene/?term=79865 "C6orf76, TLT-2, TLT2, dJ238O23.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022664 79866 BORA http://www.ncbi.nlm.nih.gov/gene/?term=79866 C13orf34 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022665 79867 TCTN2 http://www.ncbi.nlm.nih.gov/gene/?term=79867 "C12orf38, JBTS24, MKS8, TECT2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022666 79867 TCTN2 http://www.ncbi.nlm.nih.gov/gene/?term=79867 "C12orf38, JBTS24, MKS8, TECT2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022667 79867 TCTN2 http://www.ncbi.nlm.nih.gov/gene/?term=79867 "C12orf38, JBTS24, MKS8, TECT2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022668 79868 ALG13 http://www.ncbi.nlm.nih.gov/gene/?term=79868 "CDG1S, CXorf45, GLT28D1, MDS031, TDRD13, YGL047W " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022669 79869 CPSF7 http://www.ncbi.nlm.nih.gov/gene/?term=79869 CFIm59 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022670 79869 CPSF7 http://www.ncbi.nlm.nih.gov/gene/?term=79869 CFIm59 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022671 79871 RPAP2 http://www.ncbi.nlm.nih.gov/gene/?term=79871 "C1orf82, Rtr1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022672 79873 NUDT18 http://www.ncbi.nlm.nih.gov/gene/?term=79873 MTH3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022673 79874 RABEP2 http://www.ncbi.nlm.nih.gov/gene/?term=79874 FRA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022674 79876 UBA5 http://www.ncbi.nlm.nih.gov/gene/?term=79876 "THIFP1, UBE1DC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022675 79879 CCDC134 http://www.ncbi.nlm.nih.gov/gene/?term=79879 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022676 79882 ZC3H14 http://www.ncbi.nlm.nih.gov/gene/?term=79882 "MSUT-2, NY-REN-37, SUT2, UKp68 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022677 79885 HDAC11 http://www.ncbi.nlm.nih.gov/gene/?term=79885 HD11 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022678 79886 CAAP1 http://www.ncbi.nlm.nih.gov/gene/?term=79886 "C9orf82, CAAP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022679 79886 CAAP1 http://www.ncbi.nlm.nih.gov/gene/?term=79886 "C9orf82, CAAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022680 79887 PLBD1 http://www.ncbi.nlm.nih.gov/gene/?term=79887 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022681 79888 LPCAT1 http://www.ncbi.nlm.nih.gov/gene/?term=79888 "AGPAT10, AGPAT9, AYTL2, PFAAP3, lpcat " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022682 79888 LPCAT1 http://www.ncbi.nlm.nih.gov/gene/?term=79888 "AGPAT10, AGPAT9, AYTL2, PFAAP3, lpcat " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022683 79888 LPCAT1 http://www.ncbi.nlm.nih.gov/gene/?term=79888 "AGPAT10, AGPAT9, AYTL2, PFAAP3, lpcat " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022684 7988 ZNF212 http://www.ncbi.nlm.nih.gov/gene/?term=7988 "C2H2-150, ZNF182, ZNFC150 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022685 79892 MCMBP http://www.ncbi.nlm.nih.gov/gene/?term=79892 "C10orf119, MCM-BP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022686 79892 MCMBP http://www.ncbi.nlm.nih.gov/gene/?term=79892 "C10orf119, MCM-BP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022687 79893 GGNBP2 http://www.ncbi.nlm.nih.gov/gene/?term=79893 "DIF-3, DIF3, LCRG1, LZK1, ZFP403, ZNF403 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022688 79893 GGNBP2 http://www.ncbi.nlm.nih.gov/gene/?term=79893 "DIF-3, DIF3, LCRG1, LZK1, ZFP403, ZNF403 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022689 79894 ZNF672 http://www.ncbi.nlm.nih.gov/gene/?term=79894 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022690 79896 THNSL1 http://www.ncbi.nlm.nih.gov/gene/?term=79896 TSH1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022691 79897 RPP21 http://www.ncbi.nlm.nih.gov/gene/?term=79897 "C6orf135, CAT60 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022692 79901 CYBRD1 http://www.ncbi.nlm.nih.gov/gene/?term=79901 "CYB561A2, DCYTB, FRRS3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022693 79902 NUP85 http://www.ncbi.nlm.nih.gov/gene/?term=79902 "FROUNT, Nup75 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022694 79902 NUP85 http://www.ncbi.nlm.nih.gov/gene/?term=79902 "FROUNT, Nup75 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022695 79902 NUP85 http://www.ncbi.nlm.nih.gov/gene/?term=79902 "FROUNT, Nup75 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022696 79906 MORN1 http://www.ncbi.nlm.nih.gov/gene/?term=79906 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022697 79912 PYROXD1 http://www.ncbi.nlm.nih.gov/gene/?term=79912 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022698 79918 SETD6 http://www.ncbi.nlm.nih.gov/gene/?term=79918 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022699 79918 SETD6 http://www.ncbi.nlm.nih.gov/gene/?term=79918 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022700 7991 TUSC3 http://www.ncbi.nlm.nih.gov/gene/?term=7991 "D8S1992, M33, MRT22, MRT7, N33, OST3A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022701 79921 TCEAL4 http://www.ncbi.nlm.nih.gov/gene/?term=79921 "NPD017, WEX7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022702 79921 TCEAL4 http://www.ncbi.nlm.nih.gov/gene/?term=79921 "NPD017, WEX7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022703 79923 NANOG http://www.ncbi.nlm.nih.gov/gene/?term=79923 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022704 79923 NANOG http://www.ncbi.nlm.nih.gov/gene/?term=79923 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022705 79925 SPEF2 http://www.ncbi.nlm.nih.gov/gene/?term=79925 "CT122, KPL2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022706 79932 KIAA0319L http://www.ncbi.nlm.nih.gov/gene/?term=79932 AAVR mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022707 79932 KIAA0319L http://www.ncbi.nlm.nih.gov/gene/?term=79932 AAVR mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022708 79933 SYNPO2L http://www.ncbi.nlm.nih.gov/gene/?term=79933 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022709 79933 SYNPO2L http://www.ncbi.nlm.nih.gov/gene/?term=79933 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022710 79939 SLC35E1 http://www.ncbi.nlm.nih.gov/gene/?term=79939 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022711 79939 SLC35E1 http://www.ncbi.nlm.nih.gov/gene/?term=79939 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022712 79939 SLC35E1 http://www.ncbi.nlm.nih.gov/gene/?term=79939 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022713 7993 UBXN8 http://www.ncbi.nlm.nih.gov/gene/?term=7993 "D8S2298E, REP8, UBXD6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022714 79940 LINC00472 http://www.ncbi.nlm.nih.gov/gene/?term=79940 C6orf155 lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00022715 79940 LINC00472 http://www.ncbi.nlm.nih.gov/gene/?term=79940 C6orf155 lncRNA Homo sapiens 25630241 Nucleus Hela cell qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00022716 7994 KAT6A http://www.ncbi.nlm.nih.gov/gene/?term=7994 "MOZ, MRD32, MYST-3, MYST3, RUNXBP2, ZC2HC6A, ZNF220 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022717 7994 KAT6A http://www.ncbi.nlm.nih.gov/gene/?term=7994 "MOZ, MRD32, MYST-3, MYST3, RUNXBP2, ZC2HC6A, ZNF220 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022718 79954 NOL10 http://www.ncbi.nlm.nih.gov/gene/?term=79954 PQBP5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022719 79954 NOL10 http://www.ncbi.nlm.nih.gov/gene/?term=79954 PQBP5 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022720 79954 NOL10 http://www.ncbi.nlm.nih.gov/gene/?term=79954 PQBP5 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022721 79956 ERMP1 http://www.ncbi.nlm.nih.gov/gene/?term=79956 "FXNA, KIAA1815, bA207C16.3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022722 79956 ERMP1 http://www.ncbi.nlm.nih.gov/gene/?term=79956 "FXNA, KIAA1815, bA207C16.3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022723 79959 CEP76 http://www.ncbi.nlm.nih.gov/gene/?term=79959 "C18orf9, HsT1705 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022724 79960 JADE1 http://www.ncbi.nlm.nih.gov/gene/?term=79960 PHF17 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022725 79960 JADE1 http://www.ncbi.nlm.nih.gov/gene/?term=79960 PHF17 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022726 79960 JADE1 http://www.ncbi.nlm.nih.gov/gene/?term=79960 PHF17 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022727 79960 JADE1 http://www.ncbi.nlm.nih.gov/gene/?term=79960 PHF17 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022728 79960 JADE1 http://www.ncbi.nlm.nih.gov/gene/?term=79960 PHF17 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022729 79962 DNAJC22 http://www.ncbi.nlm.nih.gov/gene/?term=79962 wus mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022730 79963 ABCA11P http://www.ncbi.nlm.nih.gov/gene/?term=79963 "ABCA11, EST1133530 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022731 79966 SCD5 http://www.ncbi.nlm.nih.gov/gene/?term=79966 "ACOD4, FADS4, HSCD5, SCD2, SCD4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022732 79966 SCD5 http://www.ncbi.nlm.nih.gov/gene/?term=79966 "ACOD4, FADS4, HSCD5, SCD2, SCD4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022733 79966 SCD5 http://www.ncbi.nlm.nih.gov/gene/?term=79966 "ACOD4, FADS4, HSCD5, SCD2, SCD4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022734 79971 WLS http://www.ncbi.nlm.nih.gov/gene/?term=79971 "C1orf139, EVI, GPR177, MRP, mig-14 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022735 79977 GRHL2 http://www.ncbi.nlm.nih.gov/gene/?term=79977 "BOM, DFNA28, ECTDS, TFCP2L3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022736 79979 TRMT2B http://www.ncbi.nlm.nih.gov/gene/?term=79979 "CXorf34, dJ341D10.3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022737 79979 TRMT2B http://www.ncbi.nlm.nih.gov/gene/?term=79979 "CXorf34, dJ341D10.3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022738 79979 TRMT2B http://www.ncbi.nlm.nih.gov/gene/?term=79979 "CXorf34, dJ341D10.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022739 79980 DSN1 http://www.ncbi.nlm.nih.gov/gene/?term=79980 "C20orf172, KNL3, MIS13, dJ469A13.2, hKNL-3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022740 79982 DNAJB14 http://www.ncbi.nlm.nih.gov/gene/?term=79982 "EGNR9427, PRO34683 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022741 79987 SVEP1 http://www.ncbi.nlm.nih.gov/gene/?term=79987 "C9orf13, CCP22, POLYDOM, SEL-OB, SELOB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022742 79990 PLEKHH3 http://www.ncbi.nlm.nih.gov/gene/?term=79990 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022743 79990 PLEKHH3 http://www.ncbi.nlm.nih.gov/gene/?term=79990 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022744 79991 OBFC1 http://www.ncbi.nlm.nih.gov/gene/?term=79991 "AAF-44, AAF44, RPA-32, STN1, bA541N10.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022745 79993 ELOVL7 http://www.ncbi.nlm.nih.gov/gene/?term=79993 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022746 79993 ELOVL7 http://www.ncbi.nlm.nih.gov/gene/?term=79993 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022747 80000 GREB1L http://www.ncbi.nlm.nih.gov/gene/?term=80000 "C18orf6, KIAA1772 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022748 80003 PCNX2 http://www.ncbi.nlm.nih.gov/gene/?term=80003 PCNXL2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022749 80004 ESRP2 http://www.ncbi.nlm.nih.gov/gene/?term=80004 RBM35B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022750 80005 DOCK5 http://www.ncbi.nlm.nih.gov/gene/?term=80005 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022751 80006 TRAPPC13 http://www.ncbi.nlm.nih.gov/gene/?term=80006 C5orf44 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022752 80006 TRAPPC13 http://www.ncbi.nlm.nih.gov/gene/?term=80006 C5orf44 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022753 80007 C10orf88 http://www.ncbi.nlm.nih.gov/gene/?term=80007 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022754 80010 RMI1 http://www.ncbi.nlm.nih.gov/gene/?term=80010 "BLAP75, C9orf76, FAAP75 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022755 80011 FAM192A http://www.ncbi.nlm.nih.gov/gene/?term=80011 "C16orf94, CDA018, CDA10, NIP30 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022756 80011 FAM192A http://www.ncbi.nlm.nih.gov/gene/?term=80011 "C16orf94, CDA018, CDA10, NIP30 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022757 80014 WWC2 http://www.ncbi.nlm.nih.gov/gene/?term=80014 BOMB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022758 80018 NAA25 http://www.ncbi.nlm.nih.gov/gene/?term=80018 "C12orf30, MDM20, NAP1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022759 80018 NAA25 http://www.ncbi.nlm.nih.gov/gene/?term=80018 "C12orf30, MDM20, NAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022760 80019 UBTD1 http://www.ncbi.nlm.nih.gov/gene/?term=80019 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022761 80020 FOXRED2 http://www.ncbi.nlm.nih.gov/gene/?term=80020 ERFAD mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022762 80020 FOXRED2 http://www.ncbi.nlm.nih.gov/gene/?term=80020 ERFAD mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022763 80020 FOXRED2 http://www.ncbi.nlm.nih.gov/gene/?term=80020 ERFAD mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022764 80024 SLC8B1 http://www.ncbi.nlm.nih.gov/gene/?term=80024 "NCKX6, NCLX, SLC24A6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022765 80024 SLC8B1 http://www.ncbi.nlm.nih.gov/gene/?term=80024 "NCKX6, NCLX, SLC24A6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022766 80025 PANK2 http://www.ncbi.nlm.nih.gov/gene/?term=80025 "C20orf48, HARP, HSS, NBIA1, PKAN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022767 80025 PANK2 http://www.ncbi.nlm.nih.gov/gene/?term=80025 "C20orf48, HARP, HSS, NBIA1, PKAN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022768 80028 FBXL18 http://www.ncbi.nlm.nih.gov/gene/?term=80028 Fbl18 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022769 80028 FBXL18 http://www.ncbi.nlm.nih.gov/gene/?term=80028 Fbl18 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022770 80031 SEMA6D http://www.ncbi.nlm.nih.gov/gene/?term=80031 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022771 80045 GPR157 http://www.ncbi.nlm.nih.gov/gene/?term=80045 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022772 80055 PGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=80055 "Bst1, ISPD3024, MRT42, SPG67 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022773 80055 PGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=80055 "Bst1, ISPD3024, MRT42, SPG67 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022774 80063 ATF7IP2 http://www.ncbi.nlm.nih.gov/gene/?term=80063 MCAF2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022775 80063 ATF7IP2 http://www.ncbi.nlm.nih.gov/gene/?term=80063 MCAF2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022776 80063 ATF7IP2 http://www.ncbi.nlm.nih.gov/gene/?term=80063 MCAF2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022777 80095 ZNF606 http://www.ncbi.nlm.nih.gov/gene/?term=80095 ZNF328 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022778 80097 MZT2B http://www.ncbi.nlm.nih.gov/gene/?term=80097 "FAM128B, MOZART2B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022779 800 CALD1 http://www.ncbi.nlm.nih.gov/gene/?term=800 "CDM, H-CAD, HCAD, L-CAD, LCAD, NAG22 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022780 80115 BAIAP2L2 http://www.ncbi.nlm.nih.gov/gene/?term=80115 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022781 80124 VCPIP1 http://www.ncbi.nlm.nih.gov/gene/?term=80124 "DUBA3, VCIP135 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022782 80135 RPF1 http://www.ncbi.nlm.nih.gov/gene/?term=80135 BXDC5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022783 8013 NR4A3 http://www.ncbi.nlm.nih.gov/gene/?term=8013 "CHN, CSMF, MINOR, NOR1, TEC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022784 80142 PTGES2 http://www.ncbi.nlm.nih.gov/gene/?term=80142 "C9orf15, GBF-1, GBF1, PGES2, mPGES-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022785 80142 PTGES2 http://www.ncbi.nlm.nih.gov/gene/?term=80142 "C9orf15, GBF-1, GBF1, PGES2, mPGES-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022786 80143 SIKE1 http://www.ncbi.nlm.nih.gov/gene/?term=80143 SIKE mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022787 80143 SIKE1 http://www.ncbi.nlm.nih.gov/gene/?term=80143 SIKE mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022788 80143 SIKE1 http://www.ncbi.nlm.nih.gov/gene/?term=80143 SIKE mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022789 80143 SIKE1 http://www.ncbi.nlm.nih.gov/gene/?term=80143 SIKE mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022790 80144 FRAS1 http://www.ncbi.nlm.nih.gov/gene/?term=80144 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022791 80145 THOC7 http://www.ncbi.nlm.nih.gov/gene/?term=80145 "NIF3L1BP1, fSAP24, hTREX30 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022792 80146 UXS1 http://www.ncbi.nlm.nih.gov/gene/?term=80146 "SDR6E1, UGD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022793 80146 UXS1 http://www.ncbi.nlm.nih.gov/gene/?term=80146 "SDR6E1, UGD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022794 80148 PQLC1 http://www.ncbi.nlm.nih.gov/gene/?term=80148 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022795 80148 PQLC1 http://www.ncbi.nlm.nih.gov/gene/?term=80148 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022796 80150 ASRGL1 http://www.ncbi.nlm.nih.gov/gene/?term=80150 "ALP, ALP1, CRASH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022797 80153 EDC3 http://www.ncbi.nlm.nih.gov/gene/?term=80153 "LSM16, MRT50, YJDC, YJEFN2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022798 80153 EDC3 http://www.ncbi.nlm.nih.gov/gene/?term=80153 "LSM16, MRT50, YJDC, YJEFN2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022799 80155 NAA15 http://www.ncbi.nlm.nih.gov/gene/?term=80155 "Ga19, NARG1, NAT1P, NATH, TBDN, TBDN100 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022800 80169 CTC1 http://www.ncbi.nlm.nih.gov/gene/?term=80169 "AAF-132, AAF132, C17orf68, CRMCC, tmp494178 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022801 80169 CTC1 http://www.ncbi.nlm.nih.gov/gene/?term=80169 "AAF-132, AAF132, C17orf68, CRMCC, tmp494178 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022802 80169 CTC1 http://www.ncbi.nlm.nih.gov/gene/?term=80169 "AAF-132, AAF132, C17orf68, CRMCC, tmp494178 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022803 80177 MYCT1 http://www.ncbi.nlm.nih.gov/gene/?term=80177 MTLC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022804 80178 C16orf59 http://www.ncbi.nlm.nih.gov/gene/?term=80178 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022805 80179 MYO19 http://www.ncbi.nlm.nih.gov/gene/?term=80179 MYOHD1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022806 80179 MYO19 http://www.ncbi.nlm.nih.gov/gene/?term=80179 MYOHD1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022807 80184 CEP290 http://www.ncbi.nlm.nih.gov/gene/?term=80184 "3H11Ag, BBS14, CT87, JBTS5, LCA10, MKS4, NPHP6, POC3, SLSN6, rd16 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022808 80184 CEP290 http://www.ncbi.nlm.nih.gov/gene/?term=80184 "3H11Ag, BBS14, CT87, JBTS5, LCA10, MKS4, NPHP6, POC3, SLSN6, rd16 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022809 80185 TTI2 http://www.ncbi.nlm.nih.gov/gene/?term=80185 "C8orf41, MRT39 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022810 80185 TTI2 http://www.ncbi.nlm.nih.gov/gene/?term=80185 "C8orf41, MRT39 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022811 80194 TMEM134 http://www.ncbi.nlm.nih.gov/gene/?term=80194 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022812 80194 TMEM134 http://www.ncbi.nlm.nih.gov/gene/?term=80194 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022813 80195 TMEM254 http://www.ncbi.nlm.nih.gov/gene/?term=80195 "C10orf57, bA369J21.6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022814 80198 MUS81 http://www.ncbi.nlm.nih.gov/gene/?term=80198 SLX3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022815 8019 BRD3 http://www.ncbi.nlm.nih.gov/gene/?term=8019 "ORFX, RING3L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022816 801 CALM1 http://www.ncbi.nlm.nih.gov/gene/?term=801 "CALML2, CAMI, CPVT4, DD132, LQT14, PHKD, caM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022817 80201 HKDC1 http://www.ncbi.nlm.nih.gov/gene/?term=80201 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022818 80204 FBXO11 http://www.ncbi.nlm.nih.gov/gene/?term=80204 "FBX11, PRMT9, UBR6, UG063H01, VIT1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022819 80204 FBXO11 http://www.ncbi.nlm.nih.gov/gene/?term=80204 "FBX11, PRMT9, UBR6, UG063H01, VIT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022820 80205 CHD9 http://www.ncbi.nlm.nih.gov/gene/?term=80205 "AD013, CHD-9, CReMM, KISH2, PRIC320 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022821 80205 CHD9 http://www.ncbi.nlm.nih.gov/gene/?term=80205 "AD013, CHD-9, CReMM, KISH2, PRIC320 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022822 80207 OPA3 http://www.ncbi.nlm.nih.gov/gene/?term=80207 MGA3 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022823 80207 OPA3 http://www.ncbi.nlm.nih.gov/gene/?term=80207 MGA3 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022824 80208 SPG11 http://www.ncbi.nlm.nih.gov/gene/?term=80208 "ALS5, CMT2X, KIAA1840 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022825 80218 NAA50 http://www.ncbi.nlm.nih.gov/gene/?term=80218 "MAK3, NAT13, NAT13P, NAT5, NAT5P, SAN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022826 80218 NAA50 http://www.ncbi.nlm.nih.gov/gene/?term=80218 "MAK3, NAT13, NAT13P, NAT5, NAT5P, SAN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022827 80219 COQ10B http://www.ncbi.nlm.nih.gov/gene/?term=80219 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022828 80219 COQ10B http://www.ncbi.nlm.nih.gov/gene/?term=80219 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022829 8021 NUP214 http://www.ncbi.nlm.nih.gov/gene/?term=8021 "CAIN, CAN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022830 80221 ACSF2 http://www.ncbi.nlm.nih.gov/gene/?term=80221 "ACSMW, AVYV493 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022831 80222 TARS2 http://www.ncbi.nlm.nih.gov/gene/?term=80222 "COXPD21, TARSL1, thrRS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022832 80223 RAB11FIP1 http://www.ncbi.nlm.nih.gov/gene/?term=80223 "NOEL1A, RCP, rab11-FIP1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022833 80223 RAB11FIP1 http://www.ncbi.nlm.nih.gov/gene/?term=80223 "NOEL1A, RCP, rab11-FIP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022834 80227 PAAF1 http://www.ncbi.nlm.nih.gov/gene/?term=80227 "PAAF, Rpn14, WDR71 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022835 80227 PAAF1 http://www.ncbi.nlm.nih.gov/gene/?term=80227 "PAAF, Rpn14, WDR71 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022836 80228 ORAI2 http://www.ncbi.nlm.nih.gov/gene/?term=80228 "C7orf19, CBCIP2, MEM142B, TMEM142B " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022837 80228 ORAI2 http://www.ncbi.nlm.nih.gov/gene/?term=80228 "C7orf19, CBCIP2, MEM142B, TMEM142B " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022838 80230 RUFY1 http://www.ncbi.nlm.nih.gov/gene/?term=80230 "RABIP4, ZFYVE12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022839 80232 WDR26 http://www.ncbi.nlm.nih.gov/gene/?term=80232 "CDW2, GID7, MIP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022840 80232 WDR26 http://www.ncbi.nlm.nih.gov/gene/?term=80232 "CDW2, GID7, MIP2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022841 80232 WDR26 http://www.ncbi.nlm.nih.gov/gene/?term=80232 "CDW2, GID7, MIP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022842 80237 ELL3 http://www.ncbi.nlm.nih.gov/gene/?term=80237 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022843 80243 PREX2 http://www.ncbi.nlm.nih.gov/gene/?term=80243 "6230420N16Rik, DEP.2, DEPDC2, P-REX2, PPP1R129 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022844 80255 SLC35F5 http://www.ncbi.nlm.nih.gov/gene/?term=80255 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022845 80255 SLC35F5 http://www.ncbi.nlm.nih.gov/gene/?term=80255 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022846 80256 FAM214B http://www.ncbi.nlm.nih.gov/gene/?term=80256 KIAA1539 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022847 80262 C16orf70 http://www.ncbi.nlm.nih.gov/gene/?term=80262 "C16orf6, LIN10, lin-10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022848 80262 C16orf70 http://www.ncbi.nlm.nih.gov/gene/?term=80262 "C16orf6, LIN10, lin-10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022849 80263 TRIM45 http://www.ncbi.nlm.nih.gov/gene/?term=80263 RNF99 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022850 80263 TRIM45 http://www.ncbi.nlm.nih.gov/gene/?term=80263 RNF99 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022851 80267 EDEM3 http://www.ncbi.nlm.nih.gov/gene/?term=80267 C1orf22 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022852 80267 EDEM3 http://www.ncbi.nlm.nih.gov/gene/?term=80267 C1orf22 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022853 80270 HSD3B7 http://www.ncbi.nlm.nih.gov/gene/?term=80270 "CBAS1, PFIC4, SDR11E3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022854 80270 HSD3B7 http://www.ncbi.nlm.nih.gov/gene/?term=80270 "CBAS1, PFIC4, SDR11E3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022855 80270 HSD3B7 http://www.ncbi.nlm.nih.gov/gene/?term=80270 "CBAS1, PFIC4, SDR11E3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022856 80271 ITPKC http://www.ncbi.nlm.nih.gov/gene/?term=80271 "IP3-3KC, IP3KC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022857 80273 GRPEL1 http://www.ncbi.nlm.nih.gov/gene/?term=80273 "GrpE, HMGE, mt-GrpE#1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022858 80273 GRPEL1 http://www.ncbi.nlm.nih.gov/gene/?term=80273 "GrpE, HMGE, mt-GrpE#1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022859 8027 STAM http://www.ncbi.nlm.nih.gov/gene/?term=8027 "STAM-11, STAM " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022860 8027 STAM http://www.ncbi.nlm.nih.gov/gene/?term=8027 "STAM-1, STAM1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022861 80281 Cttnbp2nl http://www.ncbi.nlm.nih.gov/gene/?term=80281 "AA552995, AA589392, AU018624, BC003236, mKIAA1433 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022862 80284 Smim12 http://www.ncbi.nlm.nih.gov/gene/?term=80284 BC003266 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022863 80286 Tusc3 http://www.ncbi.nlm.nih.gov/gene/?term=80286 "AU022242, BC003311, N33 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022864 8028 MLLT10 http://www.ncbi.nlm.nih.gov/gene/?term=8028 AF10 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022865 8028 MLLT10 http://www.ncbi.nlm.nih.gov/gene/?term=8028 AF10 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022866 80291 Rilpl2 http://www.ncbi.nlm.nih.gov/gene/?term=80291 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022867 80297 Sptbn4 http://www.ncbi.nlm.nih.gov/gene/?term=80297 "1700022P15Rik, 5830426A08Rik, ROSA62, SpbIV, Spnb4, dyn, lnd, nmf261, nmf379, qv " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022868 80298 MTERF2 http://www.ncbi.nlm.nih.gov/gene/?term=80298 "MTERFD3, mTERFL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022869 8029 CUBN http://www.ncbi.nlm.nih.gov/gene/?term=8029 "IFCR, MGA1, gp280 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022870 80304 C2orf44 http://www.ncbi.nlm.nih.gov/gene/?term=80304 "PP384, WDCP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022871 80304 WDCP http://www.ncbi.nlm.nih.gov/gene/?term=80304 "PP384, WDCP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022872 80305 TRABD http://www.ncbi.nlm.nih.gov/gene/?term=80305 "LP6054, PP2447 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022873 80305 TRABD http://www.ncbi.nlm.nih.gov/gene/?term=80305 "LP6054, PP2447 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022874 80306 MED28 http://www.ncbi.nlm.nih.gov/gene/?term=80306 "1500003D12Rik, EG1, magicin " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022875 80306 MED28 http://www.ncbi.nlm.nih.gov/gene/?term=80306 "1500003D12Rik, EG1, magicin " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022876 80306 MED28 http://www.ncbi.nlm.nih.gov/gene/?term=80306 "1500003D12Rik, EG1, magicin " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022877 80307 FER1L4 http://www.ncbi.nlm.nih.gov/gene/?term=80307 C20orf124 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022878 80308 FLAD1 http://www.ncbi.nlm.nih.gov/gene/?term=80308 "FAD1, FADS, PP591 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022879 8030 CCDC6 http://www.ncbi.nlm.nih.gov/gene/?term=8030 "D10S170, H4, PTC, TPC, TST1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022880 8030 CCDC6 http://www.ncbi.nlm.nih.gov/gene/?term=8030 "D10S170, H4, PTC, TPC, TST1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022881 8030 CCDC6 http://www.ncbi.nlm.nih.gov/gene/?term=8030 "D10S170, H4, PTC, TPC, TST1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022882 80313 LRRC27 http://www.ncbi.nlm.nih.gov/gene/?term=80313 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022883 80313 LRRC27 http://www.ncbi.nlm.nih.gov/gene/?term=80313 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022884 80314 EPC1 http://www.ncbi.nlm.nih.gov/gene/?term=80314 Epl1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022885 80314 EPC1 http://www.ncbi.nlm.nih.gov/gene/?term=80314 Epl1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022886 80315 CPEB4 http://www.ncbi.nlm.nih.gov/gene/?term=80315 "CPE-BP4, hCPEB-4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022887 80315 CPEB4 http://www.ncbi.nlm.nih.gov/gene/?term=80315 "CPE-BP4, hCPEB-4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022888 80319 CXXC4 http://www.ncbi.nlm.nih.gov/gene/?term=80319 IDAX mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022889 8031 NCOA4 http://www.ncbi.nlm.nih.gov/gene/?term=8031 "ARA70, ELE1, PTC3, RFG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022890 80321 CEP70 http://www.ncbi.nlm.nih.gov/gene/?term=80321 BITE mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022891 80321 CEP70 http://www.ncbi.nlm.nih.gov/gene/?term=80321 BITE mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022892 80324 PUS1 http://www.ncbi.nlm.nih.gov/gene/?term=80324 MLASA1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022893 80328 ULBP2 http://www.ncbi.nlm.nih.gov/gene/?term=80328 "ALCAN-alpha, N2DL2, NKG2DL2, RAET1H " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022894 80329 ULBP1 http://www.ncbi.nlm.nih.gov/gene/?term=80329 "N2DL-1, NKG2DL1, RAET1I " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022895 80329 ULBP1 http://www.ncbi.nlm.nih.gov/gene/?term=80329 "N2DL-1, NKG2DL1, RAET1I " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022896 80331 DNAJC5 http://www.ncbi.nlm.nih.gov/gene/?term=80331 "CLN4, CLN4B, CSPA, NCL, mir-941-2, mir-941-3, mir-941-4, mir-941-5, DNAJC5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022897 80333 KCNIP4 http://www.ncbi.nlm.nih.gov/gene/?term=80333 "CALP, KCHIP4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022898 80335 WDR82 http://www.ncbi.nlm.nih.gov/gene/?term=80335 "MST107, MSTP107, PRO2730, PRO34047, SWD2, TMEM113A, WDR82 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022899 80344 DCAF11 http://www.ncbi.nlm.nih.gov/gene/?term=80344 "GL014, PRO2389, WDR23 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022900 80346 REEP4 http://www.ncbi.nlm.nih.gov/gene/?term=80346 "C8orf20, PP432, Yip2c " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022901 80347 COASY http://www.ncbi.nlm.nih.gov/gene/?term=80347 "DPCK, NBIA6, NBP, PPAT, UKR1, pOV-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022902 80347 COASY http://www.ncbi.nlm.nih.gov/gene/?term=80347 "DPCK, NBIA6, NBP, PPAT, UKR1, pOV-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022903 80349 WDR61 http://www.ncbi.nlm.nih.gov/gene/?term=80349 "REC14, SKI8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022904 8034 SLC25A16 http://www.ncbi.nlm.nih.gov/gene/?term=8034 "D10S105E, GDA, GDC, HGT.1, ML7, hML7 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022905 8034 SLC25A16 http://www.ncbi.nlm.nih.gov/gene/?term=8034 "D10S105E, GDA, GDC, HGT.1, ML7, hML7 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022906 8034 SLC25A16 http://www.ncbi.nlm.nih.gov/gene/?term=8034 "D10S105E, GDA, GDC, HGT.1, ML7, hML7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022907 80351 TNKS2 http://www.ncbi.nlm.nih.gov/gene/?term=80351 "ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, pART6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022908 80351 TNKS2 http://www.ncbi.nlm.nih.gov/gene/?term=80351 "ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, pART6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022909 80351 TNKS2 http://www.ncbi.nlm.nih.gov/gene/?term=80351 "ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, pART6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022910 80352 RNF39 http://www.ncbi.nlm.nih.gov/gene/?term=80352 "HZF, HZFW, LIRF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022911 80381 CD276 http://www.ncbi.nlm.nih.gov/gene/?term=80381 "4Ig-B7-H3, B7-H3, B7H3, B7RP-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022912 80384 Tex21 http://www.ncbi.nlm.nih.gov/gene/?term=80384 "4931406F04Rik, 4931412D23Rik, 4931421K24Rik, tsec-2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022913 80385 Tusc2 http://www.ncbi.nlm.nih.gov/gene/?term=80385 "1190001E22Rik, AA407686, Fus1, Lgcc, PAP, Pdap2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022914 8038 ADAM12 http://www.ncbi.nlm.nih.gov/gene/?term=8038 "ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022915 804477 ND2 http://www.ncbi.nlm.nih.gov/gene/?term=804477 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00022916 8050 PDHX http://www.ncbi.nlm.nih.gov/gene/?term=8050 "DLDBP, E3BP, OPDX, PDX1, proX " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022917 8050 PDHX http://www.ncbi.nlm.nih.gov/gene/?term=8050 "DLDBP, E3BP, OPDX, PDX1, proX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022918 805 CALM2 http://www.ncbi.nlm.nih.gov/gene/?term=805 "CAMII, LQT15, PHKD, PHKD2, caM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022919 8061 FOSL1 http://www.ncbi.nlm.nih.gov/gene/?term=8061 "FRA, FRA1, fra-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022920 8065 CUL5 http://www.ncbi.nlm.nih.gov/gene/?term=8065 "VACM-1, VACM1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022921 8065 CUL5 http://www.ncbi.nlm.nih.gov/gene/?term=8065 "VACM-1, VACM1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022922 8065 CUL5 http://www.ncbi.nlm.nih.gov/gene/?term=8065 "VACM-1, VACM1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022923 80700 UBXN6 http://www.ncbi.nlm.nih.gov/gene/?term=80700 "UBXD1, UBXDC2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022924 80700 UBXN6 http://www.ncbi.nlm.nih.gov/gene/?term=80700 "UBXD1, UBXDC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022925 80707 Wwox http://www.ncbi.nlm.nih.gov/gene/?term=80707 "5330426P09Rik, 9030416C10Rik, WOX1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022926 80719 Igsf6 http://www.ncbi.nlm.nih.gov/gene/?term=80719 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022927 80724 ACAD10 http://www.ncbi.nlm.nih.gov/gene/?term=80724 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022928 80727 TTYH3 http://www.ncbi.nlm.nih.gov/gene/?term=80727 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022929 80727 TTYH3 http://www.ncbi.nlm.nih.gov/gene/?term=80727 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022930 80728 ARHGAP39 http://www.ncbi.nlm.nih.gov/gene/?term=80728 "CrGAP, Vilse " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022931 80732 Mynn http://www.ncbi.nlm.nih.gov/gene/?term=80732 "2810011C24Rik, AA415053, AI661031, AW049392, Mynr, SBBIZ1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022932 8073 PTP4A2 http://www.ncbi.nlm.nih.gov/gene/?term=8073 "HH13, HH7-2, HU-PP-1, OV-1, PRL-2, PRL2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022933 8073 PTP4A2 http://www.ncbi.nlm.nih.gov/gene/?term=8073 "HH13, HH7-2, HU-PP-1, OV-1, PRL-2, PRL2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022934 80742 PRR3 http://www.ncbi.nlm.nih.gov/gene/?term=80742 CAT56 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022935 80743 Vps16 http://www.ncbi.nlm.nih.gov/gene/?term=80743 1810074M16Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022936 80745 THUMPD2 http://www.ncbi.nlm.nih.gov/gene/?term=80745 C2orf8 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022937 80746 TSEN2 http://www.ncbi.nlm.nih.gov/gene/?term=80746 "PCH2B, SEN2, SEN2L " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022938 80746 TSEN2 http://www.ncbi.nlm.nih.gov/gene/?term=80746 "PCH2B, SEN2, SEN2L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022939 80750 N4bp1 http://www.ncbi.nlm.nih.gov/gene/?term=80750 "AI481586, C81621 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022940 80755 AARSD1 http://www.ncbi.nlm.nih.gov/gene/?term=80755 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022941 80758 PRR7 http://www.ncbi.nlm.nih.gov/gene/?term=80758 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022942 80759 KHDC1 http://www.ncbi.nlm.nih.gov/gene/?term=80759 "C6orf147, C6orf148, Em:AC019205.8, NDG1, bA257K9.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022943 80762 NDFIP1 http://www.ncbi.nlm.nih.gov/gene/?term=80762 N4WBP5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022944 80762 NDFIP1 http://www.ncbi.nlm.nih.gov/gene/?term=80762 N4WBP5 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022945 80764 THAP7 http://www.ncbi.nlm.nih.gov/gene/?term=80764 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022946 8076 MFAP5 http://www.ncbi.nlm.nih.gov/gene/?term=8076 "AAT9, MAGP-2, MAGP2, MFAP-5, MP25 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022947 80772 CPTP http://www.ncbi.nlm.nih.gov/gene/?term=80772 GLTPD1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022948 80775 TMEM177 http://www.ncbi.nlm.nih.gov/gene/?term=80775 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022949 80776 B9D2 http://www.ncbi.nlm.nih.gov/gene/?term=80776 "ICIS-1, MKS10, MKSR2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022950 80777 CYB5B http://www.ncbi.nlm.nih.gov/gene/?term=80777 "CYB5-M, CYPB5M, OMB5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022951 80777 CYB5B http://www.ncbi.nlm.nih.gov/gene/?term=80777 "CYB5-M, CYPB5M, OMB5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022952 80781 COL18A1 http://www.ncbi.nlm.nih.gov/gene/?term=80781 "KNO, KNO1, KS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022953 80781 COL18A1 http://www.ncbi.nlm.nih.gov/gene/?term=80781 "KNO, KNO1, KS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022954 80789 INTS5 http://www.ncbi.nlm.nih.gov/gene/?term=80789 "INT5, KIAA1698 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022955 80789 INTS5 http://www.ncbi.nlm.nih.gov/gene/?term=80789 "INT5, KIAA1698 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022956 8078 USP5 http://www.ncbi.nlm.nih.gov/gene/?term=8078 ISOT mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022957 8078 USP5 http://www.ncbi.nlm.nih.gov/gene/?term=8078 ISOT mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022958 8078 USP5 http://www.ncbi.nlm.nih.gov/gene/?term=8078 ISOT mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022959 80790 CMIP http://www.ncbi.nlm.nih.gov/gene/?term=80790 TCMIP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022960 8079 MLF2 http://www.ncbi.nlm.nih.gov/gene/?term=8079 NTN4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022961 8079 MLF2 http://www.ncbi.nlm.nih.gov/gene/?term=8079 NTN4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022962 80817 CEP44 http://www.ncbi.nlm.nih.gov/gene/?term=80817 "KIAA1712, PS1TP3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022963 80817 CEP44 http://www.ncbi.nlm.nih.gov/gene/?term=80817 "KIAA1712, PS1TP3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022964 80817 CEP44 http://www.ncbi.nlm.nih.gov/gene/?term=80817 "KIAA1712, PS1TP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022965 80818 ZNF436 http://www.ncbi.nlm.nih.gov/gene/?term=80818 "ZNF, Zfp46 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022966 80821 DDHD1 http://www.ncbi.nlm.nih.gov/gene/?term=80821 "PA-PLA1, PAPLA1, SPG28 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022967 80824 DUSP16 http://www.ncbi.nlm.nih.gov/gene/?term=80824 "MKP-7, MKP7 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022968 80824 DUSP16 http://www.ncbi.nlm.nih.gov/gene/?term=80824 "MKP-7, MKP7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022969 80830 APOL6 http://www.ncbi.nlm.nih.gov/gene/?term=80830 "APOL-VI, APOLVI " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022970 80830 APOL6 http://www.ncbi.nlm.nih.gov/gene/?term=80830 "APOL-VI, APOLVI " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00022971 80838 Hist1h1a http://www.ncbi.nlm.nih.gov/gene/?term=80838 "H1.1, H1a, H1f1, H1var3 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022972 80843 Sec61a1 http://www.ncbi.nlm.nih.gov/gene/80843 Sec61a mRNA Rattus norvegicus 15485813 Mitochondrion Hepatoma cell qRT-PCR "Real-time RT-PCR revealed that the sec61a transcript was found in the mitochondrial fraction, but unlike ucp2 and oxa1 mRNA, sec61α mRNA was not removed from this fraction when mitochondria were harvested without attached polysomes (Fig. 4) (25). " RLID00022973 80851 SH3BP5L http://www.ncbi.nlm.nih.gov/gene/?term=80851 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022974 80853 KDM7A http://www.ncbi.nlm.nih.gov/gene/?term=80853 JHDM1D mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022975 80854 SETD7 http://www.ncbi.nlm.nih.gov/gene/?term=80854 "KMT7, SET7, SET7/9, SET9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022976 80856 KIAA1715 http://www.ncbi.nlm.nih.gov/gene/?term=80856 "LNP, LNP1, Ul, ulnaless " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022977 80859 Nfkbiz http://www.ncbi.nlm.nih.gov/gene/?term=80859 "AA408868, INAP, Mail " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022978 8087 FXR1 http://www.ncbi.nlm.nih.gov/gene/?term=8087 FXR1P mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00022979 8087 FXR1 http://www.ncbi.nlm.nih.gov/gene/?term=8087 FXR1P mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022980 8087 FXR1 http://www.ncbi.nlm.nih.gov/gene/?term=8087 FXR1P mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022981 80886 Senp3 http://www.ncbi.nlm.nih.gov/gene/?term=80886 "AA408656, Smt3ip, Smt3ip1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022982 80890 Trim2 http://www.ncbi.nlm.nih.gov/gene/?term=80890 "mKIAA0517, narf " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00022983 80892 Zfhx4 http://www.ncbi.nlm.nih.gov/gene/?term=80892 "A930021B15, C130041O22Rik, Zfh-4, Zfh4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022984 80895 ILKAP http://www.ncbi.nlm.nih.gov/gene/?term=80895 "ILKAP23, PP2C-DELTA, PPM1O, ILKAP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022985 80896 NPL http://www.ncbi.nlm.nih.gov/gene/?term=80896 "C112, C1orf13, NAL, NPL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022986 80898 Erap1 http://www.ncbi.nlm.nih.gov/gene/?term=80898 "Arts1, ERAAP, PILSA, PILSAP " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022987 8089 YEATS4 http://www.ncbi.nlm.nih.gov/gene/?term=8089 "4930573H17Rik, B230215M10Rik, GAS41, NUBI-1, YAF9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022988 8089 YEATS4 http://www.ncbi.nlm.nih.gov/gene/?term=8089 "4930573H17Rik, B230215M10Rik, GAS41, NUBI-1, YAF9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022989 808 CALM3 http://www.ncbi.nlm.nih.gov/gene/?term=808 "HEL-S-72, PHKD, PHKD3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022990 80902 Zfp202 http://www.ncbi.nlm.nih.gov/gene/?term=80902 "C130037E22Rik, Znf202 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022991 80905 Polh http://www.ncbi.nlm.nih.gov/gene/?term=80905 "RAD30A, XPV " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022992 80912 Pum1 http://www.ncbi.nlm.nih.gov/gene/?term=80912 "AA517475, Pumm, mKIAA0099 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022993 80913 Pum2 http://www.ncbi.nlm.nih.gov/gene/?term=80913 "5730503J23Rik, Pumm2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022994 8091 HMGA2 http://www.ncbi.nlm.nih.gov/gene/?term=8091 "BABL, HMGI-C, HMGIC, LIPO, STQTL9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022995 80986 Ckap2 http://www.ncbi.nlm.nih.gov/gene/?term=80986 "AI461656, AW228814, LB1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00022996 8099 CDK2AP1 http://www.ncbi.nlm.nih.gov/gene/?term=8099 "DOC1, DORC1, ST19, doc-1, p12DOC-1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00022997 8099 CDK2AP1 http://www.ncbi.nlm.nih.gov/gene/?term=8099 "DOC1, DORC1, ST19, doc-1, p12DOC-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00022998 8099 CDK2AP1 http://www.ncbi.nlm.nih.gov/gene/?term=8099 "DOC1, DORC1, ST19, doc-1, p12DOC-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00022999 81000 Rad54l2 http://www.ncbi.nlm.nih.gov/gene/?term=81000 "Arip4, D130058C05, G630026H09Rik, Srisnf2l " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023000 81003 Trim23 http://www.ncbi.nlm.nih.gov/gene/?term=81003 "6330516O20Rik, AI450195, Arfd1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023001 8100 IFT88 http://www.ncbi.nlm.nih.gov/gene/?term=8100 "D13S1056E, DAF19, TG737, TTC10, hTg737 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023002 81011 Vmn1r148 http://www.ncbi.nlm.nih.gov/gene/?term=81011 "V1rd14, V3R8 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00023003 81012 Vmn1r171 http://www.ncbi.nlm.nih.gov/gene/?term=81012 "V1rd7, V3R7 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023004 81013 Vmn1r65 http://www.ncbi.nlm.nih.gov/gene/?term=81013 "V1rd6, V3R6 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023005 81027 TUBB1 http://www.ncbi.nlm.nih.gov/gene/?term=81027 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023006 81029 WNT5B http://www.ncbi.nlm.nih.gov/gene/?term=81029 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023007 81031 SLC2A10 http://www.ncbi.nlm.nih.gov/gene/?term=81031 "ATS, GLUT10 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023008 81031 SLC2A10 http://www.ncbi.nlm.nih.gov/gene/?term=81031 "ATS, GLUT10 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023009 81031 SLC2A10 http://www.ncbi.nlm.nih.gov/gene/?term=81031 "ATS, GLUT10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023010 81034 SLC25A32 http://www.ncbi.nlm.nih.gov/gene/?term=81034 "MFT, MFTC, RREI " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023011 81034 SLC25A32 http://www.ncbi.nlm.nih.gov/gene/?term=81034 "MFT, MFTC, RREI " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023012 81034 SLC25A32 http://www.ncbi.nlm.nih.gov/gene/?term=81034 "MFT, MFTC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023013 81037 CLPTM1L http://www.ncbi.nlm.nih.gov/gene/?term=81037 CRR9 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023014 8106 PABPN1 http://www.ncbi.nlm.nih.gov/gene/?term=8106 "OPMD, PAB2, PABII, PABP-2, PABP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023015 8106 PABPN1 http://www.ncbi.nlm.nih.gov/gene/?term=8106 "OPMD, PAB2, PABII, PABP-2, PABP2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023016 8106 PABPN1 http://www.ncbi.nlm.nih.gov/gene/?term=8106 "OPMD, PAB2, PABII, PABP-2, PABP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023017 811 CALR http://www.ncbi.nlm.nih.gov/gene/?term=811 "CRT, HEL-S-99n, RO, SSA, cC1qR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023018 811 CALR http://www.ncbi.nlm.nih.gov/gene/?term=811 "CRT, HEL-S-99n, RO, SSA, cC1qR " mRNA Homo sapiens 12923260 Endoplasmic reticulum T-cell line Jurkat S1 nuclease protection assays "Oligonucleotide probes were designed to hybridize with mRNAs encoding representative members of three classes of protein: soluble (GAPDH, Hsp90, and LDH), ER resident membrane (Sec61a and calnexin), and ER resident lumenal (BiP, calreticulin, and GRP94). " RLID00023019 811 CALR http://www.ncbi.nlm.nih.gov/gene/?term=811 "CRT, HEL-S-99n, RO, SSA, cC1qR " mRNA Homo sapiens 12923260 Ribosome T-cell line Jurkat S1 nuclease protection assays "Using the procedures described above, the subcellular distribution of individual mRNAs in the cytosol and rough ER polysome fractions of Jurkat and J558 cells was determined. mRNAs for resident proteins of the ER lumen, including BiP, calreticulin, and GRP94, were also highly enriched on membrane-bound polysomes. " RLID00023020 811 CALR http://www.ncbi.nlm.nih.gov/gene/?term=811 "CRT, HEL-S-99n, RO, SSA, cC1qR " mRNA Homo sapiens 21431749 Endoplasmic reticulum HEK293 cell Northern blot "Similarly, Northern blot analysis of the mRNA composition of the cytosol and membrane fractions show that the cytosol fraction is enriched for mRNAs encoding histone (H3F3A) and GAPDH, whereas the membrane fraction is enriched in mRNAs encoding ER resident proteins, such as GRP94 and calreticulin (Fig. 2 B). " RLID00023021 811 CALR http://www.ncbi.nlm.nih.gov/gene/?term=811 "CRT, HEL-S-99n, RO, SSA, cC1qR " mRNA Homo sapiens 25063809 Ribosome HeLa cell qRT-PCR Figure 1: Endoplasmic reticulum-associated mRNAs are partitioned between detergent-resistant and detergent-sensitive membrane domains. Data are collected from Figure 1. RLID00023022 811 CALR http://www.ncbi.nlm.nih.gov/gene/?term=811 "CRT, HEL-S-99n, RO, SSA, cC1qR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023023 811 CALR http://www.ncbi.nlm.nih.gov/gene/?term=811 "CRT, HEL-S-99n, RO, SSA, cC1qR " mRNA Homo sapiens 22679391 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "Figure 2: ALPP and CALR, but not t-ftz or INSL3, mRNA remain associated with the ER independently of ribosomes and translation. (A–E) COS-7 cells were transfected with plasmids containing either the t-ftz (A), INSL3 (A–B), ALPP (A, C), cyto-ALPP (a version of ALPP lacking signal sequence and transmembrane domain coding regions; A, D–E), or CALR (A) genes and allowed to express mRNA for 18�4 h. The cells were then treated with DMSO (Cont), puromycin, or HHT for 30 min, and then extracted with digitonin alone or with 20 mM EDTA. Cells were then fixed, stained for mRNA using specific FISH probes, and imaged (see panels B–D for examples). The fluorescence intensities of mRNA in the ER and nucleus in the micrographs were quantified (A). Each bar represents the average and standard error of three independent experiments, each consisting of the average integrated intensity of 30 cells over background. Note that although ribosome disruption caused INSL3 mRNA to dissociate from the ER, the nuclear mRNA was unaffected (B, nuclei are denoted by arrows). (E) A single field of view containing a single HHT-treated, digitonin-extracted, COS-7 cell expressing cyto-ALPP mRNA. cyto-ALPP mRNA was visualized by FISH and for Trapα protein by immunofluorescence. Note the extensive co-localization of cyto-ALPP mRNA (red) and Trapα (green) in the overlay. All scale bars?=?20 um. Data are collected from Figure 2. " RLID00023024 811 CALR http://www.ncbi.nlm.nih.gov/gene/?term=811 "CRT, HEL-S-99n, RO, SSA, cC1qR " mRNA Homo sapiens 22679391 Endoplasmic reticulum U2OS cell RT-PCR "Figure 3B: The levels of several transcripts in the ER fraction were analyzed as in (A). Measured transcripts include those encoding ER luminal proteins (BiP, Calreticulin), ER membrane proteins (Inositol-3-phosphate Receptor (IP3 Receptor), Sec61α, Trapα, and Fatty Acid Desaturase 3 (FADS3)), a Golgi protein (Mannosidase 2A (Man2A)), plasma membrane proteins (Integrin β1, and Transferrin Receptor (Tf Receptor)), and a secreted protein (Interleukin 7 (IL7)). All measurements were standardized to the level of mRNA in the ER fraction from control cells. Data are collected from Figure 3B. " RLID00023025 811 CALR http://www.ncbi.nlm.nih.gov/gene/?term=811 "CRT, HEL-S-99n, RO, SSA, cC1qR " mRNA Homo sapiens 22679391 Nucleus COS-7 cell Fluorescence in situ hybridization "Figure 2: ALPP and CALR, but not t-ftz or INSL3, mRNA remain associated with the ER independently of ribosomes and translation. (A–E) COS-7 cells were transfected with plasmids containing either the t-ftz (A), INSL3 (A–B), ALPP (A, C), cyto-ALPP (a version of ALPP lacking signal sequence and transmembrane domain coding regions; A, D–E), or CALR (A) genes and allowed to express mRNA for 18�4 h. The cells were then treated with DMSO (Cont), puromycin, or HHT for 30 min, and then extracted with digitonin alone or with 20 mM EDTA. Cells were then fixed, stained for mRNA using specific FISH probes, and imaged (see panels B–D for examples). The fluorescence intensities of mRNA in the ER and nucleus in the micrographs were quantified (A). Each bar represents the average and standard error of three independent experiments, each consisting of the average integrated intensity of 30 cells over background. Note that although ribosome disruption caused INSL3 mRNA to dissociate from the ER, the nuclear mRNA was unaffected (B, nuclei are denoted by arrows). (E) A single field of view containing a single HHT-treated, digitonin-extracted, COS-7 cell expressing cyto-ALPP mRNA. cyto-ALPP mRNA was visualized by FISH and for Trapα protein by immunofluorescence. Note the extensive co-localization of cyto-ALPP mRNA (red) and Trapα (green) in the overlay. All scale bars?=?20 um. Data are collected from Figure 2. " RLID00023026 811 CALR http://www.ncbi.nlm.nih.gov/gene/?term=811 "CRT, HEL-S-99n, RO, SSA, cC1qR " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023027 811 CALR http://www.ncbi.nlm.nih.gov/gene/?term=811 "RO, CRT, SSA, cC1qR, HEL-S-99n " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00023028 8120 AP3B2 http://www.ncbi.nlm.nih.gov/gene/?term=8120 NAPTB mRNA Homo sapiens 24019514 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmid containing either full-length ALPP, t-ftz, AP1, AP2, AP3, AP4, or AP5 and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (C or Ctrl) or HHT (H) for 30 min and then extracted with digitonin. Cells were then fixed, stained for mRNAs using specific FISH probes (ftz probe was used to detect AP1-5), and imaged. Figure 3A, quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 3. " RLID00023029 8120 AP3B2 http://www.ncbi.nlm.nih.gov/gene/?term=8120 NAPTB mRNA Homo sapiens 24019514 Nucleus COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmid containing either full-length ALPP, t-ftz, AP1, AP2, AP3, AP4, or AP5 and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (C or Ctrl) or HHT (H) for 30 min and then extracted with digitonin. Cells were then fixed, stained for mRNAs using specific FISH probes (ftz probe was used to detect AP1-5), and imaged. Figure 3A, quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 3. " RLID00023030 8120 AP3B2 http://www.ncbi.nlm.nih.gov/gene/?term=8120 NAPTB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023031 8123 PWAR5 http://www.ncbi.nlm.nih.gov/gene/?term=8123 "D15S226E, PAR-5, PAR5 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023032 8125 ANP32A http://www.ncbi.nlm.nih.gov/gene/?term=8125 "C15orf1, HPPCn, I1PP2A, LANP, MAPM, PHAP1, PHAPI, PP32 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023033 81285 OR51E2 http://www.ncbi.nlm.nih.gov/gene/?term=81285 "OR51E3P, OR52A2, PSGR " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023034 81285 OR51E2 http://www.ncbi.nlm.nih.gov/gene/?term=81285 "OR51E3P, OR52A2, PSGR " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023035 8131 NPRL3 http://www.ncbi.nlm.nih.gov/gene/?term=8131 "C16orf35, CGTHBA, HS-40, MARE, NPR3, RMD11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023036 8139 GAN http://www.ncbi.nlm.nih.gov/gene/?term=8139 "GAN1, KLHL16 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023037 8139 GAN http://www.ncbi.nlm.nih.gov/gene/?term=8139 "GAN1, KLHL16 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023038 813 CALU http://www.ncbi.nlm.nih.gov/gene/?term=813 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023039 813 CALU http://www.ncbi.nlm.nih.gov/gene/?term=813 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023040 813 CALU http://www.ncbi.nlm.nih.gov/gene/?term=813 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023041 8140 SLC7A5 http://www.ncbi.nlm.nih.gov/gene/?term=8140 "4F2LC, CD98, D16S469E, E16, LAT1, MPE16, hLAT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023042 8140 SLC7A5 http://www.ncbi.nlm.nih.gov/gene/?term=8140 "4F2LC, CD98, D16S469E, E16, LAT1, MPE16, hLAT1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023043 8140 SLC7A5 http://www.ncbi.nlm.nih.gov/gene/?term=8140 "4F2LC, CD98, D16S469E, E16, LAT1, MPE16, hLAT1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023044 8140 SLC7A5 http://www.ncbi.nlm.nih.gov/gene/?term=8140 "4F2LC, CD98, D16S469E, E16, LAT1, MPE16, hLAT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023045 814596 nad4 http://www.ncbi.nlm.nih.gov/gene/?term=814596 ArthMp051 mRNA Arabidopsis thaliana 21251101 Mitochondrion Plant Next-generation sequencing A restorer of fertility-like PPR gene is required for 5-end processing of the nad4 mRNA in mitochondria of Arabidopsis thaliana. RLID00023046 814686 RGA1 http://www.ncbi.nlm.nih.gov/gene/?term=814686 "AT2G01570, F2I9.19, F2I9_19, REPRESSOR OF GA, REPRESSOR OF GA1-3 1, RGA " mRNA Arabidopsis thaliana 23622241 Ribosome - RT-PCR "MiRNA target transcripts, such as AGO1, PHB, CSD2, SPL3, SCL6, and TCP4, showed a significant increase in membrane-bound polysomes (MBPs) association in the double mutant, whereas non-target transcripts such as UBQ5, eIF4A, ACTIN8, At2g01570, At5g28770, and At5g66770 were similarly distributed along membrane-bound polysomes (MBPs) fractions in wild type and amp1 lamp1 (Fig 6E). " RLID00023047 81488 POLR2M http://www.ncbi.nlm.nih.gov/gene/?term=81488 "GCOM1, GRINL1A, Gdown, Gdown1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023048 81488 POLR2M http://www.ncbi.nlm.nih.gov/gene/?term=81488 "GCOM1, GRINL1A, Gdown, Gdown1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023049 81488 POLR2M http://www.ncbi.nlm.nih.gov/gene/?term=81488 "GCOM1, GRINL1A, Gdown, Gdown1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023050 81489 Dnajb1 http://www.ncbi.nlm.nih.gov/gene/?term=81489 "0610007I11Rik, DjB1, HSPF1, Hdj1, Hsp40 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023051 8148 TAF15 http://www.ncbi.nlm.nih.gov/gene/?term=8148 "Npl3, RBP56, TAF2N, TAFII68 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023052 81490 PTDSS2 http://www.ncbi.nlm.nih.gov/gene/?term=81490 PSS2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023053 81493 SYNC http://www.ncbi.nlm.nih.gov/gene/?term=81493 "SYNC1, SYNCOILIN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023054 81502 HM13 http://www.ncbi.nlm.nih.gov/gene/?term=81502 "H13, IMP1, IMPAS, IMPAS-1, MSTP086, PSENL3, PSL3, SPP, SPPL1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023055 81532 MOB2 http://www.ncbi.nlm.nih.gov/gene/?term=81532 HCCA2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023056 81533 ITFG1 http://www.ncbi.nlm.nih.gov/gene/?term=81533 "2310047C21Rik, CDA08, LNKN-1, TIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023057 81533 ITFG1 http://www.ncbi.nlm.nih.gov/gene/?term=81533 "2310047C21Rik, CDA08, LNKN-1, TIP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023058 81535 Sgpp1 http://www.ncbi.nlm.nih.gov/gene/?term=81535 "AI463453, SPP, SPP1, Spph1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023059 81537 SGPP1 http://www.ncbi.nlm.nih.gov/gene/?term=81537 SPPase1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023060 81537 SGPP1 http://www.ncbi.nlm.nih.gov/gene/?term=81537 SPPase1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023061 81537 SGPP1 http://www.ncbi.nlm.nih.gov/gene/?term=81537 SPPase1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023062 81539 SLC38A1 http://www.ncbi.nlm.nih.gov/gene/?term=81539 "ATA1, NAT2, SAT1, SNAT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023063 8153 RND2 http://www.ncbi.nlm.nih.gov/gene/?term=8153 "ARHN, RHO7, RhoN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023064 8153 RND2 http://www.ncbi.nlm.nih.gov/gene/?term=8153 "ARHN, RHO7, RhoN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023065 8153 RND2 http://www.ncbi.nlm.nih.gov/gene/?term=8153 "ARHN, RHO7, RhoN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023066 81542 TMX1 http://www.ncbi.nlm.nih.gov/gene/?term=81542 "PDIA11, TMX, TXNDC, TXNDC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023067 81542 TMX1 http://www.ncbi.nlm.nih.gov/gene/?term=81542 "PDIA11, TMX, TXNDC, TXNDC1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023068 81542 TMX1 http://www.ncbi.nlm.nih.gov/gene/?term=81542 "PDIA11, TMX, TXNDC, TXNDC1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023069 81542 TMX1 http://www.ncbi.nlm.nih.gov/gene/?term=81542 "PDIA11, TMX, TXNDC, TXNDC1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023070 81545 FBXO38 http://www.ncbi.nlm.nih.gov/gene/?term=81545 "Fbx38, HMN2D, MOKA, SP329 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023071 81545 FBXO38 http://www.ncbi.nlm.nih.gov/gene/?term=81545 "Fbx38, HMN2D, MOKA, SP329 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023072 81550 TDRD3 http://www.ncbi.nlm.nih.gov/gene/?term=81550 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023073 81550 TDRD3 http://www.ncbi.nlm.nih.gov/gene/?term=81550 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023074 81550 TDRD3 http://www.ncbi.nlm.nih.gov/gene/?term=81550 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023075 81553 FAM49A http://www.ncbi.nlm.nih.gov/gene/?term=81553 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023076 81555 YIPF5 http://www.ncbi.nlm.nih.gov/gene/?term=81555 "FinGER5, SB140, SMAP-5, SMAP5, YIP1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023077 81555 YIPF5 http://www.ncbi.nlm.nih.gov/gene/?term=81555 "FinGER5, SB140, SMAP-5, SMAP5, YIP1A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023078 81555 YIPF5 http://www.ncbi.nlm.nih.gov/gene/?term=81555 "FinGER5, SB140, SMAP-5, SMAP5, YIP1A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023079 81556 VWA9 http://www.ncbi.nlm.nih.gov/gene/?term=81556 C15orf44 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023080 81557 MAGED4B http://www.ncbi.nlm.nih.gov/gene/?term=81557 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023081 81559 TRIM11 http://www.ncbi.nlm.nih.gov/gene/?term=81559 "BIA1, RNF92 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023082 81559 TRIM11 http://www.ncbi.nlm.nih.gov/gene/?term=81559 "BIA1, RNF92 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023083 81562 LMAN2L http://www.ncbi.nlm.nih.gov/gene/?term=81562 "MRT52, VIPL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023084 81562 LMAN2L http://www.ncbi.nlm.nih.gov/gene/?term=81562 VIPL mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023085 81565 NDEL1 http://www.ncbi.nlm.nih.gov/gene/?term=81565 "EOPA, MITAP1, NDE1L1, NDE2, NUDEL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023086 81565 NDEL1 http://www.ncbi.nlm.nih.gov/gene/?term=81565 "EOPA, MITAP1, NDE1L1, NDE2, NUDEL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023087 81566 CSRNP2 http://www.ncbi.nlm.nih.gov/gene/?term=81566 "C12orf2, C12orf22, FAM130A1, PPP1R72, TAIP-12 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023088 81567 TXNDC5 http://www.ncbi.nlm.nih.gov/gene/?term=81567 "ENDOPDI, ERP46, HCC-2, HCC2, PDIA15, STRF8, UNQ364 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023089 81567 TXNDC5 http://www.ncbi.nlm.nih.gov/gene/?term=81567 "ENDOPDI, ERP46, HCC-2, HCC2, PDIA15, STRF8, UNQ364 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023090 81567 TXNDC5 http://www.ncbi.nlm.nih.gov/gene/?term=81567 "ENDOPDI, ERP46, HCC-2, HCC2, PDIA15, STRF8, UNQ364 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023091 81570 CLPB http://www.ncbi.nlm.nih.gov/gene/?term=81570 "ANKCLB, HSP78, MEGCANN, MGCA7, SKD3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023092 81570 CLPB http://www.ncbi.nlm.nih.gov/gene/?term=81570 "ANKCLB, HSP78, MEGCANN, MGCA7, SKD3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023093 81572 PDRG1 http://www.ncbi.nlm.nih.gov/gene/?term=81572 "C20orf126, PDRG " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023094 81573 ANKRD13C http://www.ncbi.nlm.nih.gov/gene/?term=81573 dJ677H15.3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023095 81575 APOLD1 http://www.ncbi.nlm.nih.gov/gene/?term=81575 VERGE mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023096 81576 CCDC130 http://www.ncbi.nlm.nih.gov/gene/?term=81576 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023097 81577 GFOD2 http://www.ncbi.nlm.nih.gov/gene/?term=81577 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023098 81579 PLA2G12A http://www.ncbi.nlm.nih.gov/gene/?term=81579 "GXII, PLA2G12, ROSSY " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023099 81579 PLA2G12A http://www.ncbi.nlm.nih.gov/gene/?term=81579 "GXII, PLA2G12, ROSSY " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023100 81579 PLA2G12A http://www.ncbi.nlm.nih.gov/gene/?term=81579 "GXII, PLA2G12, ROSSY " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023101 815 CAMK2A http://www.ncbi.nlm.nih.gov/gene/?term=815 CAMKA mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023102 81602 CDADC1 http://www.ncbi.nlm.nih.gov/gene/?term=81602 "NYD-SP15, bA103J18.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023103 81603 TRIM8 http://www.ncbi.nlm.nih.gov/gene/?term=81603 "GERP, RNF27 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023104 81605 URM1 http://www.ncbi.nlm.nih.gov/gene/?term=81605 C9orf74 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023105 81605 URM1 http://www.ncbi.nlm.nih.gov/gene/?term=81605 C9orf74 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023106 81605 URM1 http://www.ncbi.nlm.nih.gov/gene/?term=81605 C9orf74 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023107 81609 SNX27 http://www.ncbi.nlm.nih.gov/gene/?term=81609 "MRT1, MY014 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023108 81609 SNX27 http://www.ncbi.nlm.nih.gov/gene/?term=81609 "MRT1, MY014 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023109 81609 SNX27 http://www.ncbi.nlm.nih.gov/gene/?term=81609 "MRT1, MY014 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023110 81609 SNX27 http://www.ncbi.nlm.nih.gov/gene/?term=81609 "MRT1, MY014 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023111 81609 SNX27 http://www.ncbi.nlm.nih.gov/gene/?term=81609 "MRT1, MY014 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023112 81610 FAM83D http://www.ncbi.nlm.nih.gov/gene/?term=81610 "C20orf129, CHICA, dJ616B8.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023113 81610 FAM83D http://www.ncbi.nlm.nih.gov/gene/?term=81610 "C20orf129, CHICA, dJ616B8.3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023114 81610 FAM83D http://www.ncbi.nlm.nih.gov/gene/?term=81610 "C20orf129, CHICA, dJ616B8.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023115 81611 ANP32E http://www.ncbi.nlm.nih.gov/gene/?term=81611 "LANP-L, LANPL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023116 81611 ANP32E http://www.ncbi.nlm.nih.gov/gene/?term=81611 "LANP-L, LANPL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023117 81611 ANP32E http://www.ncbi.nlm.nih.gov/gene/?term=81611 "LANP-L, LANPL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023118 81614 NIPA2 http://www.ncbi.nlm.nih.gov/gene/?term=81614 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023119 81614 NIPA2 http://www.ncbi.nlm.nih.gov/gene/?term=81614 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023120 81618 ITM2C http://www.ncbi.nlm.nih.gov/gene/?term=81618 "BRI3, BRICD2C, E25, E25C, ITM3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023121 81618 ITM2C http://www.ncbi.nlm.nih.gov/gene/?term=81618 "BRI3, BRICD2C, E25, E25C, ITM3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023122 81619 TSPAN14 http://www.ncbi.nlm.nih.gov/gene/?term=81619 "DC-TM4F2, TM4SF14 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023123 8161 COIL http://www.ncbi.nlm.nih.gov/gene/?term=8161 "CLN80, p80-coilin " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023124 81620 CDT1 http://www.ncbi.nlm.nih.gov/gene/?term=81620 "DUP, RIS2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023125 81622 UNC93B1 http://www.ncbi.nlm.nih.gov/gene/?term=81622 "IIAE1, UNC93, UNC93B, Unc-93B1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023126 81627 TRMT1L http://www.ncbi.nlm.nih.gov/gene/?term=81627 "C1orf25, MST070, MSTP070, TRM1L, bG120K12.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023127 81628 TSC22D4 http://www.ncbi.nlm.nih.gov/gene/?term=81628 "THG-1, THG1, TILZ2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023128 81628 TSC22D4 http://www.ncbi.nlm.nih.gov/gene/?term=81628 "THG-1, THG1, TILZ2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023129 81631 MAP1LC3B http://www.ncbi.nlm.nih.gov/gene/?term=81631 "ATG8F, LC3B, MAP1A/1BLC3-a, MAP1LC3B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023130 81631 MAP1LC3B http://www.ncbi.nlm.nih.gov/gene/?term=81631 "ATG8F, LC3B, MAP1A/1BLC3-a, MAP1LC3B " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023131 81631 MAP1LC3B http://www.ncbi.nlm.nih.gov/gene/?term=81631 "ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023132 81657 Gabbr1 http://www.ncbi.nlm.nih.gov/gene/?term=81657 "MRG15, Tex189, TEG-189, MORFRG15, mKIAA4002 " mRNA Rattus norvegicus 12081654 Dendrite Spinal neuron In situ hybridization "On spinal neurons both r1 and r2 mRNAs showed somatodendritic localization, extending out for >100 mm with punctate appearance especially in adult cells. Interestingly, a dendritic localization of the r1 and r2 mRNAs (Fig. 4C, arrows) was observed. However, in several neuronsthe mRNAs for r1 or r2 could be found more than 100 mm away from the cell soma, indicating localization to distal dendrites (Table 1). " RLID00023133 8165 AKAP1 http://www.ncbi.nlm.nih.gov/gene/?term=8165 "AKAP, AKAP121, AKAP149, AKAP84, D-AKAP1, PPP1R43, PRKA1, SAKAP84, TDRD17 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023134 81669 CCNL2 http://www.ncbi.nlm.nih.gov/gene/?term=81669 "ANIA-6B, CCNM, CCNS, HCLA-ISO, HLA-ISO, PCEE, SB138 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023135 81671 VMP1 http://www.ncbi.nlm.nih.gov/gene/?term=81671 "EPG3, TANGO5, TMEM49 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023136 81671 VMP1 http://www.ncbi.nlm.nih.gov/gene/?term=81671 "EPG3, TANGO5, TMEM49 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023137 81687 Mmp9 http://www.ncbi.nlm.nih.gov/gene/?term=81687 mRNA Rattus norvegicus 23077039 Dendrite Hippocampus Fluorescence in situ hybridization "In aggregate, our findings show that MMP-9 mRNA is transported to dendrites and locally translated and that the protein is released in an activity-dependent manner. " RLID00023138 81688 C6orf62 http://www.ncbi.nlm.nih.gov/gene/?term=81688 "Nbla00237, XTP12, dJ30M3.2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023139 81688 C6orf62 http://www.ncbi.nlm.nih.gov/gene/?term=81688 "Nbla00237, XTP12, dJ30M3.2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023140 81688 C6orf62 http://www.ncbi.nlm.nih.gov/gene/?term=81688 "Nbla00237, XTP12, dJ30M3.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023141 81689 ISCA1 http://www.ncbi.nlm.nih.gov/gene/?term=81689 "HBLD2, ISA1, hIscA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023142 81689 ISCA1 http://www.ncbi.nlm.nih.gov/gene/?term=81689 "HBLD2, ISA1, hIscA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023143 81691 LOC81691 http://www.ncbi.nlm.nih.gov/gene/?term=81691 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023144 81693 AMN http://www.ncbi.nlm.nih.gov/gene/?term=81693 "PRO1028, amnionless " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023145 81702 Ankrd17 http://www.ncbi.nlm.nih.gov/gene/?term=81702 "4933425K22Rik, A130069E23Rik, A930008M01, AA407558, AA516750, AU040470, Foe, Gtar, Mask, mKIAA0697 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023146 81704 DOCK8 http://www.ncbi.nlm.nih.gov/gene/?term=81704 "HEL-205, MRD2, ZIR8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023147 81706 PPP1R14C http://www.ncbi.nlm.nih.gov/gene/?term=81706 "CPI17-like, KEPI, NY-BR-81 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023148 81706 PPP1R14C http://www.ncbi.nlm.nih.gov/gene/?term=81706 "CPI17-like, KEPI, NY-BR-81 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023149 8170 SLC14A2 http://www.ncbi.nlm.nih.gov/gene/?term=8170 "HUT2, UT-A2, UT2, UTA, UTR, hUT-A6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023150 8170 SLC14A2 http://www.ncbi.nlm.nih.gov/gene/?term=8170 "HUT2, UT-A2, UT2, UTA, UTR, hUT-A6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023151 817365 CSD2 http://www.ncbi.nlm.nih.gov/gene/?term=817365 "AT2G28190, COPPER/ZINC SUPEROXIDE DISMUTASE, COPPER/ZINC SUPEROXIDE DISMUTASE 2, CZSOD2, F24D13.2, F24D13_2, copper/zinc superoxide dismutase 2 " mRNA Arabidopsis thaliana 23622241 Ribosome - RT-PCR "MiRNA target transcripts, such as AGO1, PHB, CSD2, SPL3, SCL6, and TCP4, showed a significant increase in membrane-bound polysomes (MBPs) association in the double mutant, whereas non-target transcripts such as UBQ5, eIF4A, ACTIN8, At2g01570, At5g28770, and At5g66770 were similarly distributed along membrane-bound polysomes (MBPs) fractions in wild type and amp1 lamp1 (Fig 6E). " RLID00023152 8175 SF3A2 http://www.ncbi.nlm.nih.gov/gene/?term=8175 "PRP11, PRPF11, SAP62, SF3a66 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023153 81768 Rpl22 http://www.ncbi.nlm.nih.gov/gene/?term=81768 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00023154 81770 Rpl37 http://www.ncbi.nlm.nih.gov/gene/?term=81770 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00023155 81786 TRIM7 http://www.ncbi.nlm.nih.gov/gene/?term=81786 "GNIP, RNF90 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023156 81788 NUAK2 http://www.ncbi.nlm.nih.gov/gene/?term=81788 SNARK mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023157 81788 NUAK2 http://www.ncbi.nlm.nih.gov/gene/?term=81788 SNARK mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023158 81789 TIGD6 http://www.ncbi.nlm.nih.gov/gene/?term=81789 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023159 8178 ELL http://www.ncbi.nlm.nih.gov/gene/?term=8178 "C19orf17, ELL1, MEN, PPP1R68 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023160 81790 RNF170 http://www.ncbi.nlm.nih.gov/gene/?term=81790 "ADSA, SNAX1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023161 81790 RNF170 http://www.ncbi.nlm.nih.gov/gene/?term=81790 "ADSA, SNAX1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023162 817948 SPL3 http://www.ncbi.nlm.nih.gov/gene/?term=817948 "AT2G33810, T1B8.11, T1B8_11, squamosa promoter binding protein-like 3 " mRNA Arabidopsis thaliana 23622241 Ribosome - RT-PCR "MiRNA target transcripts, such as AGO1, PHB, CSD2, SPL3, SCL6, and TCP4, showed a significant increase in membrane-bound polysomes (MBPs) association in the double mutant, whereas non-target transcripts such as UBQ5, eIF4A, ACTIN8, At2g01570, At5g28770, and At5g66770 were similarly distributed along membrane-bound polysomes (MBPs) fractions in wild type and amp1 lamp1 (Fig 6E). " RLID00023163 817 CAMK2D http://www.ncbi.nlm.nih.gov/gene/?term=817 CAMKD mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023164 817 CAMK2D http://www.ncbi.nlm.nih.gov/gene/?term=817 CAMKD mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023165 817 CAMK2D http://www.ncbi.nlm.nih.gov/gene/?term=817 CAMKD mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023166 818036 PHB http://www.ncbi.nlm.nih.gov/gene/?term=818036 "AT2G34710, ARABIDOPSIS THALIANA HOMEOBOX PROTEIN 14, ATHB-14, ATHB14, PHABULOSA, PHABULOSA 1D, PHB-1D, T29F13.8, T29F13_8 " mRNA Arabidopsis thaliana 23622241 Ribosome - RT-PCR "MiRNA target transcripts, such as AGO1, PHB, CSD2, SPL3, SCL6, and TCP4, showed a significant increase in membrane-bound polysomes (MBPs) association in the double mutant, whereas non-target transcripts such as UBQ5, eIF4A, ACTIN8, At2g01570, At5g28770, and At5g66770 were similarly distributed along membrane-bound polysomes (MBPs) fractions in wild type and amp1 lamp1 (Fig 6E). " RLID00023167 81814 Tmsb4x http://www.ncbi.nlm.nih.gov/gene/?term=81814 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00023168 81818 Vim http://www.ncbi.nlm.nih.gov/gene/?term=81818 mRNA Rattus norvegicus 15673657 Axon Dorsal root ganglia RT-PCR "By RT-PCR, we were able to detect peripherin, vimentin, and cofilin mRNAs in DRG axonal preparations (Fig. 4A). By RT-PCR, rTpm3 mRNA was detected in axonal preparations from the cultured DRGs (Fig. 4A). alpha-B crystallin and HSP70 mRNAs appeared more concentrated in the axonal than in the cellbody RNA preparations. HSP60 and HSP90 mRNAs show relatively equal levels in the axonal and cell-body RNAs, whereas HSP27 and grp75 appear more concentrated in the cell-body than in the axonal RNAs. Resident-ER proteins and encoding mRNAs in DRG axons. A, RT-PCR for rat grp78/BiP, calreticulin, and ERp29 mRNAs shows that these transcripts extend into the DRG axons. Ubiquitin C-terminal hydrolase L1 (Uch-L1), SP22, r-synuclein, and dismutase (SOD1) were detected by the MS analyses, and RT-PCR confirmed that the mRNAs encoding each of these extends into the DRG axons (Fig. 7A). " RLID00023169 81818 Vim http://www.ncbi.nlm.nih.gov/gene/?term=81818 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00023170 81822 Actb http://www.ncbi.nlm.nih.gov/gene/?term=81822 Actx mRNA Rattus norvegicus 20118926 Axon Sensory neuron RT-PCR "Few 3’UTRs that direct the transport of mRNAs to dendrites have been identified. beta-actin mRNA (Actb) transport in axons, for example, is regulated by the interaction of the 3’zipcode element with the zipcode binding protein (ZBP), and a localization motif within the 3’UTR of the Ran GTPase RanBP1 mRNA (Ranbp1) contributes to the axonal targeting of this transcript in adult sensory neurons. " RLID00023171 81822 Actb http://www.ncbi.nlm.nih.gov/gene/?term=81822 Actx mRNA Rattus norvegicus 20308067 Axon Neuron Fluorescence in situ hybridization "Beta-Actin and gamma-actin mRNAs show characteristic localization, with beta-actin mRNA extending into the distal axons and gamma-actin mRNA being restricted to the proximal segment of the axon. " RLID00023172 81822 Actb http://www.ncbi.nlm.nih.gov/gene/?term=81822 Actx mRNA Rattus norvegicus 21471362 Dendrite Hippocampus|Cortical cell Fluorescence in situ hybridization Zipcode binding protein 1 (ZBP1) controls β-actin mRNA transport and translation in dendrites. Fluorescence in situ hybridization with probes specific to β-actin mRNA revealed its presence in puncta in cell soma and in dendrites of control cells transfected with pSuper on DIV7 (Fig. 8A). RLID00023173 81822 Actb http://www.ncbi.nlm.nih.gov/gene/?term=81822 Actx mRNA Rattus norvegicus 22355657 Dendrite Cortical neuron Fluorescence in situ hybridization "Here we report that Htt and the huntingtin-associated protein 1 (HAP1) are co-localized with the microtubule motor proteins, the KIF5A kinesin and dynein, during dendritic transport of β-actin mRNA. " RLID00023174 81822 Actb http://www.ncbi.nlm.nih.gov/gene/?term=81822 Actx mRNA Rattus norvegicus 26180210 Axon Spinal cord In situ hybridization "By quantitative fluorescent in situ hybridization combined with immunofluorescence to unambiguously distinguish intra-axonal mRNAs, we show that regenerating spinal cord axons contain β-actin, GAP-43, Neuritin, Reg3a, Hamp, and Importin β1 mRNAs. " RLID00023175 81822 Actb http://www.ncbi.nlm.nih.gov/gene/?term=81822 Actx mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00023176 81839 VANGL1 http://www.ncbi.nlm.nih.gov/gene/?term=81839 "KITENIN, LPP2, STB2, STBM2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023177 81839 VANGL1 http://www.ncbi.nlm.nih.gov/gene/?term=81839 "KITENIN, LPP2, STB2, STBM2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023178 81846 SBF2 http://www.ncbi.nlm.nih.gov/gene/?term=81846 "CMT4B2, DENND7B, MTMR13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023179 81846 SBF2 http://www.ncbi.nlm.nih.gov/gene/?term=81846 "CMT4B2, DENND7B, MTMR13 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023180 81846 SBF2 http://www.ncbi.nlm.nih.gov/gene/?term=81846 "CMT4B2, DENND7B, MTMR13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023181 81848 SPRY4 http://www.ncbi.nlm.nih.gov/gene/?term=81848 HH17 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023182 81853 TMEM14B http://www.ncbi.nlm.nih.gov/gene/?term=81853 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023183 81853 TMEM14B http://www.ncbi.nlm.nih.gov/gene/?term=81853 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023184 81855 SFXN3 http://www.ncbi.nlm.nih.gov/gene/?term=81855 "BA108L7.2, SFX3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023185 81858 SHARPIN http://www.ncbi.nlm.nih.gov/gene/?term=81858 SIPL1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023186 81858 SHARPIN http://www.ncbi.nlm.nih.gov/gene/?term=81858 SIPL1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023187 81873 ARPC5L http://www.ncbi.nlm.nih.gov/gene/?term=81873 ARC16-2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023188 81876 RAB1B http://www.ncbi.nlm.nih.gov/gene/?term=81876 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023189 81876 RAB1B http://www.ncbi.nlm.nih.gov/gene/?term=81876 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023190 81876 RAB1B http://www.ncbi.nlm.nih.gov/gene/?term=81876 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023191 81888 HYI http://www.ncbi.nlm.nih.gov/gene/?term=81888 HT036 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023192 81889 FAHD1 http://www.ncbi.nlm.nih.gov/gene/?term=81889 "C16orf36, YISKL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023193 81890 QTRT1 http://www.ncbi.nlm.nih.gov/gene/?term=81890 "FP3235, TGT, TGUT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023194 81892 SLIRP http://www.ncbi.nlm.nih.gov/gene/?term=81892 "C14orf156, DC50, PD04872 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023195 81898 Sf3b1 http://www.ncbi.nlm.nih.gov/gene/?term=81898 "155kDa, 2810001M05Rik, AA409119, Prp10, SAP155, SF3b155, TA-8, Targ4 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023196 8189 SYMPK http://www.ncbi.nlm.nih.gov/gene/?term=8189 "SPK, SYM " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023197 8189 SYMPK http://www.ncbi.nlm.nih.gov/gene/?term=8189 "SPK, SYM " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023198 8189 SYMPK http://www.ncbi.nlm.nih.gov/gene/?term=8189 "SPK, SYM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023199 818 CAMK2G http://www.ncbi.nlm.nih.gov/gene/?term=818 "CAMK, CAMK-II, CAMKG " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023200 818 CAMK2G http://www.ncbi.nlm.nih.gov/gene/?term=818 "CAMK, CAMK-II, CAMKG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023201 81909 Zfpl1 http://www.ncbi.nlm.nih.gov/gene/?term=81909 1500015B20Rik mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023202 81910 Rrbp1 http://www.ncbi.nlm.nih.gov/gene/?term=81910 "1700087N07Rik, 5730465C04Rik, ES/130, mKIAA1398, mRRp0, mRRp1.8, mRRp10, mRRp15a, mRRp15b, mRRp16.8, mRRp2, mRRp41, mRRp47, mRRp5.4, p180 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023203 81918 Pard3 http://www.ncbi.nlm.nih.gov/gene/?term=81918 Par3 mRNA Rattus norvegicus 19620967 Axon Neuron Fluorescence in situ hybridization "Par3 mRNA is localized to developing axons, and NGF and netrin-1 trigger its local translation. " RLID00023204 81926 ABHD17A http://www.ncbi.nlm.nih.gov/gene/?term=81926 "C19orf27, FAM108A1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023205 81926 ABHD17A http://www.ncbi.nlm.nih.gov/gene/?term=81926 "C19orf27, FAM108A1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023206 81928 CABLES2 http://www.ncbi.nlm.nih.gov/gene/?term=81928 "C20orf150, dJ908M14.2, ik3-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023207 81929 SEH1L http://www.ncbi.nlm.nih.gov/gene/?term=81929 "SEC13L, SEH1A, SEH1B, Seh1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023208 81929 SEH1L http://www.ncbi.nlm.nih.gov/gene/?term=81929 "SEC13L, SEH1A, SEH1B, Seh1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023209 8192 CLPP http://www.ncbi.nlm.nih.gov/gene/?term=8192 "DFNB81, PRLTS3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023210 81931 ZNF93 http://www.ncbi.nlm.nih.gov/gene/?term=81931 "HPF34, HTF34, TF34, ZNF505 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023211 81932 HDHD3 http://www.ncbi.nlm.nih.gov/gene/?term=81932 "2810435D12Rik, C9orf158 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023212 81932 HDHD3 http://www.ncbi.nlm.nih.gov/gene/?term=81932 "2810435D12Rik, C9orf158 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023213 8195 MKKS http://www.ncbi.nlm.nih.gov/gene/?term=8195 "BBS6, HMCS, KMS, MKS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023214 819 CAMLG http://www.ncbi.nlm.nih.gov/gene/?term=819 "CAML, GET2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023215 819 CAMLG http://www.ncbi.nlm.nih.gov/gene/?term=819 "CAML, GET2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023216 819 CAMLG http://www.ncbi.nlm.nih.gov/gene/?term=819 "CAML, GET2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023217 81 ACTN4 http://www.ncbi.nlm.nih.gov/gene/?term=81 "ACTININ-4, FSGS, FSGS1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023218 81 ACTN4 http://www.ncbi.nlm.nih.gov/gene/?term=81 "ACTININ-4, FSGS, FSGS1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023219 81 ACTN4 http://www.ncbi.nlm.nih.gov/gene/?term=81 "ACTININ-4, FSGS, FSGS1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023220 8202 NCOA3 http://www.ncbi.nlm.nih.gov/gene/?term=8202 "ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023221 8202 NCOA3 http://www.ncbi.nlm.nih.gov/gene/?term=8202 "ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023222 8204 NRIP1 http://www.ncbi.nlm.nih.gov/gene/?term=8204 RIP140 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023223 8204 NRIP1 http://www.ncbi.nlm.nih.gov/gene/?term=8204 RIP140 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023224 820605 EIF4A1 http://www.ncbi.nlm.nih.gov/gene/?term=820605 "AT3G13920, RH4, TIF4A1, eukaryotic translation initiation factor 4A1 " mRNA Arabidopsis thaliana 23622241 Ribosome - RT-PCR "MiRNA target transcripts, such as AGO1, PHB, CSD2, SPL3, SCL6, and TCP4, showed a significant increase in membrane-bound polysomes (MBPs) association in the double mutant, whereas non-target transcripts such as UBQ5, eIF4A, ACTIN8, At2g01570, At5g28770, and At5g66770 were similarly distributed along membrane-bound polysomes (MBPs) fractions in wild type and amp1 lamp1 (Fig 6E). " RLID00023225 820732 TCP4 http://www.ncbi.nlm.nih.gov/gene/?term=820732 "AT3G15030, MEE35, TCP family transcription factor 4, maternal effect embryo arrest 35 " mRNA Arabidopsis thaliana 23622241 Ribosome - RT-PCR "MiRNA target transcripts, such as AGO1, PHB, CSD2, SPL3, SCL6, and TCP4, showed a significant increase in membrane-bound polysomes (MBPs) association in the double mutant, whereas non-target transcripts such as UBQ5, eIF4A, ACTIN8, At2g01570, At5g28770, and At5g66770 were similarly distributed along membrane-bound polysomes (MBPs) fractions in wild type and amp1 lamp1 (Fig 6E). " RLID00023226 8208 CHAF1B http://www.ncbi.nlm.nih.gov/gene/?term=8208 "CAF-1, CAF-IP60, CAF1, CAF1A, CAF1P60, MPHOSPH7, MPP7 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023227 8208 CHAF1B http://www.ncbi.nlm.nih.gov/gene/?term=8208 "CAF-1, CAF-IP60, CAF1, CAF1A, CAF1P60, MPHOSPH7, MPP7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023228 8209 C21orf33 http://www.ncbi.nlm.nih.gov/gene/?term=8209 "ES1, GT335, HES1, KNPH, KNPI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023229 8209 C21orf33 http://www.ncbi.nlm.nih.gov/gene/?term=8209 "ES1, GT335, HES1, KNPH, KNPI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023230 8214 DGCR6 http://www.ncbi.nlm.nih.gov/gene/?term=8214 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023231 8216 LZTR1 http://www.ncbi.nlm.nih.gov/gene/?term=8216 "BTBD29, LZTR-1, NS10, SWNTS2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023232 8216 LZTR1 http://www.ncbi.nlm.nih.gov/gene/?term=8216 "BTBD29, LZTR-1, NS10, SWNTS2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023233 8218 CLTCL1 http://www.ncbi.nlm.nih.gov/gene/?term=8218 "CHC22, CLH22, CLTCL, CLTD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023234 821 CANX http://www.ncbi.nlm.nih.gov/gene/?term=821 "CNX, IP90, P90 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023235 821 CANX http://www.ncbi.nlm.nih.gov/gene/?term=821 "CNX, IP90, P90 " mRNA Homo sapiens 12923260 Endoplasmic reticulum T-cell line Jurkat S1 nuclease protection assays "Oligonucleotide probes were designed to hybridize with mRNAs encoding representative members of three classes of protein: soluble (GAPDH, Hsp90, and LDH), ER resident membrane (Sec61a and calnexin), and ER resident lumenal (BiP, calreticulin, and GRP94). " RLID00023236 821 CANX http://www.ncbi.nlm.nih.gov/gene/?term=821 "CNX, IP90, P90 " mRNA Homo sapiens 12923260 Ribosome T-cell line Jurkat S1 nuclease protection assays "Using the procedures described above, the subcellular distribution of individual mRNAs in the cytosol and rough ER polysome fractions of Jurkat and J558 cells was determined. As depicted in Figure 4, Sec61a and calnexin were highly enriched in the membrane-bound fraction, as may be predicted for those mRNAs encoding signal sequences. " RLID00023237 821 CANX http://www.ncbi.nlm.nih.gov/gene/?term=821 "CNX, IP90, P90 " mRNA Homo sapiens 20453113 Ribosome NCI/ADR-RES cell qRT-PCR "The relative partitioning of both cytosolic (ACTB, H3.3) and ER-bound (MDR1, CANX) transcripts between both fractions was marked, despite the small carryover of cytosol in the ER fraction (Fig. 2B). Polysome profile analyses from the isolated fractions indicated that these transcripts migrated in polyribosome-containing fractions (Fig. 2C). Notably, the distribution of ER-bound transcripts between the ER and cytosol did not change on arsenite treatment of NCI/ADR-RES cells (Fig. 2D). Data are collected from Figure 2. " RLID00023238 821 CANX http://www.ncbi.nlm.nih.gov/gene/?term=821 "CNX, IP90, P90 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023239 821 CANX http://www.ncbi.nlm.nih.gov/gene/?term=821 "CNX, IP90, P90 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023240 821 CANX http://www.ncbi.nlm.nih.gov/gene/?term=821 "CNX, P90, IP90 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Northern blot "FIGURE 4. Steady-state mRNA partitioning between cytosolic and ER-bound polysomes. Total RNA was isolated from cytosol and ER membrane fractions of Jurkat and J558 cells, as indicated in Figure 1A. For each reaction, 10 ug of RNA was incubated with one of eight [32P]-labeled oligonucleotide probes representing three different classes of genes, based on the type of protein encoded: cytosolic, ER membrane, and ER lumenal. The nuclease-protected RNA fragments from parallel reactions with cytosol and ER-derived RNA were purified and separated by denaturing acrylamide gel electrophoresis. Quantification was performed by phosphorimager analysis; photostimulated luminescence output (PSL) values are indicated. Digital images of the phosphorimager output are depicted. The data are collected from Figure 4. " RLID00023241 8220 DGCR14 http://www.ncbi.nlm.nih.gov/gene/?term=8220 "DGCR13, DGS-H, DGS-I, DGSH, DGSI, ES2, Es2el " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023242 8225 GTPBP6 http://www.ncbi.nlm.nih.gov/gene/?term=8225 PGPL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023243 8226 PUDP http://www.ncbi.nlm.nih.gov/gene/?term=8226 "DXF68S1E, FAM16AX, GS1, HDHD1, HDHD1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023244 8226 PUDP http://www.ncbi.nlm.nih.gov/gene/?term=8226 "DXF68S1E, FAM16AX, GS1, HDHD1, HDHD1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023245 8228 PNPLA4 http://www.ncbi.nlm.nih.gov/gene/?term=8228 "DXS1283E, GS2, iPLA2eta " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023246 8228 PNPLA4 http://www.ncbi.nlm.nih.gov/gene/?term=8228 "DXS1283E, GS2, iPLA2eta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023247 822 CAPG http://www.ncbi.nlm.nih.gov/gene/?term=822 "AFCP, HEL-S-66, MCP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023248 8233 ZRSR2 http://www.ncbi.nlm.nih.gov/gene/?term=8233 "U2AF1-RS2, U2AF1L2, U2AF1RS2, URP, ZC3H22 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023249 8239 USP9X http://www.ncbi.nlm.nih.gov/gene/?term=8239 "DFFRX, FAF, FAM, MRX99, MRXS99F " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023250 8239 USP9X http://www.ncbi.nlm.nih.gov/gene/?term=8239 "DFFRX, FAF, FAM, MRX99, MRXS99F " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023251 8239 USP9X http://www.ncbi.nlm.nih.gov/gene/?term=8239 "DFFRX, FAF, FAM, MRX99, MRXS99F " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023252 8239 USP9X http://www.ncbi.nlm.nih.gov/gene/?term=8239 "DFFRX, FAF, FAM, MRX99, MRXS99F " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023253 8239 USP9X http://www.ncbi.nlm.nih.gov/gene/?term=8239 "DFFRX, FAF, FAM, MRX99 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023254 823 CAPN1 http://www.ncbi.nlm.nih.gov/gene/?term=823 "CANP, CANP1, CANPL1, muCANP, muCL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023255 823 CAPN1 http://www.ncbi.nlm.nih.gov/gene/?term=823 "CANP, CANP1, CANPL1, muCANP, muCL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023256 8241 RBM10 http://www.ncbi.nlm.nih.gov/gene/?term=8241 "DXS8237E, GPATC9, GPATCH9, S1-1, TARPS, ZRANB5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023257 8241 RBM10 http://www.ncbi.nlm.nih.gov/gene/?term=8241 "DXS8237E, GPATC9, GPATCH9, S1-1, TARPS, ZRANB5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023258 8242 KDM5C http://www.ncbi.nlm.nih.gov/gene/?term=8242 "DXS1272E, JARID1C, MRX13, MRXJ, MRXSCJ, MRXSJ, SMCX, XE169 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023259 8242 KDM5C http://www.ncbi.nlm.nih.gov/gene/?term=8242 "DXS1272E, JARID1C, MRX13, MRXJ, MRXSCJ, MRXSJ, SMCX, XE169 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023260 8243 SMC1A http://www.ncbi.nlm.nih.gov/gene/?term=8243 "CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023261 8243 SMC1A http://www.ncbi.nlm.nih.gov/gene/?term=8243 "CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023262 8243 SMC1A http://www.ncbi.nlm.nih.gov/gene/?term=8243 "CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023263 824 CAPN2 http://www.ncbi.nlm.nih.gov/gene/?term=824 "CANP2, CANPL2, CANPml, mCANP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023264 824 CAPN2 http://www.ncbi.nlm.nih.gov/gene/?term=824 "CANP2, CANPL2, CANPml, mCANP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023265 824 CAPN2 http://www.ncbi.nlm.nih.gov/gene/?term=824 "CANP2, CANPL2, CANPml, mCANP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023266 825398 UBQ5 http://www.ncbi.nlm.nih.gov/gene/?term=825398 "AT3G62250, ubiquitin 5 " mRNA Arabidopsis thaliana 23622241 Ribosome - RT-PCR "MiRNA target transcripts, such as AGO1, PHB, CSD2, SPL3, SCL6, and TCP4, showed a significant increase in membrane-bound polysomes (MBPs) association in the double mutant, whereas non-target transcripts such as UBQ5, eIF4A, ACTIN8, At2g01570, At5g28770, and At5g66770 were similarly distributed along membrane-bound polysomes (MBPs) fractions in wild type and amp1 lamp1 (Fig 6E). " RLID00023267 825 CAPN3 http://www.ncbi.nlm.nih.gov/gene/?term=825 "CANP3, CANPL3, LGMD2, LGMD2A, nCL-1, p94 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023268 8260 NAA10 http://www.ncbi.nlm.nih.gov/gene/?term=8260 "ARD1, ARD1A, ARD1P, DXS707, MCOPS1, NATD, OGDNS, TE2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023269 8260 NAA10 http://www.ncbi.nlm.nih.gov/gene/?term=8260 "ARD1, ARD1A, ARD1P, DXS707, MCOPS1, NATD, OGDNS, TE2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023270 8266 UBL4A http://www.ncbi.nlm.nih.gov/gene/?term=8266 "DX254E, DXS254E, G6PD, GDX, GET5, MDY2, TMA24, UBL4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023271 8266 UBL4A http://www.ncbi.nlm.nih.gov/gene/?term=8266 "DX254E, DXS254E, G6PD, GDX, GET5, MDY2, TMA24, UBL4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023272 8266 UBL4A http://www.ncbi.nlm.nih.gov/gene/?term=8266 "DX254E, DXS254E, G6PD, GDX, GET5, MDY2, TMA24, UBL4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023273 8269 TMEM187 http://www.ncbi.nlm.nih.gov/gene/?term=8269 "CXorf12, DXS9878E, ITBA1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023274 826 CAPNS1 http://www.ncbi.nlm.nih.gov/gene/?term=826 "CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023275 826 CAPNS1 http://www.ncbi.nlm.nih.gov/gene/?term=826 "CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023276 826 CAPNS1 http://www.ncbi.nlm.nih.gov/gene/?term=826 "CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023277 8270 LAGE3 http://www.ncbi.nlm.nih.gov/gene/?term=8270 "CVG5, DXS9879E, DXS9951E, ESO3, ITBA2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023278 8270 LAGE3 http://www.ncbi.nlm.nih.gov/gene/?term=8270 "CVG5, DXS9879E, DXS9951E, ESO3, ITBA2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023279 8273 SLC10A3 http://www.ncbi.nlm.nih.gov/gene/?term=8273 "DXS253E, P3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023280 8287 USP9Y http://www.ncbi.nlm.nih.gov/gene/?term=8287 "DFFRY, SPGFY2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023281 8290 HIST3H3 http://www.ncbi.nlm.nih.gov/gene/?term=8290 "H3.4, H3/g, H3FT, H3t " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023282 8290 HIST3H3 http://www.ncbi.nlm.nih.gov/gene/?term=8290 "H3.4, H3/g, H3FT, H3t " mRNA Homo sapiens 20453113 Cytosol NCI/ADR-RES cell qRT-PCR "The relative partitioning of both cytosolic (ACTB, H3.3) and ER-bound (MDR1, CANX) transcripts between both fractions was marked, despite the small carryover of cytosol in the ER fraction (Fig. 2B). Polysome profile analyses from the isolated fractions indicated that these transcripts migrated in polyribosome-containing fractions (Fig. 2C). Notably, the distribution of ER-bound transcripts between the ER and cytosol did not change on arsenite treatment of NCI/ADR-RES cells (Fig. 2D). Data are collected from Figure 2. " RLID00023283 8293 SERF1A http://www.ncbi.nlm.nih.gov/gene/?term=8293 "4F5, FAM2A, H4F5, SERF1, SMAM1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023284 8293 SERF1A http://www.ncbi.nlm.nih.gov/gene/?term=8293 "4F5, FAM2A, H4F5, SERF1, SMAM1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023285 8293 SERF1A http://www.ncbi.nlm.nih.gov/gene/?term=8293 "4F5, FAM2A, H4F5, SERF1, SMAM1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023286 8294 HIST1H4I http://www.ncbi.nlm.nih.gov/gene/?term=8294 "H4/m, H4FM, H4M " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023287 8294 HIST1H4I http://www.ncbi.nlm.nih.gov/gene/?term=8294 "H4/m, H4FM, H4M " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023288 8295 TRRAP http://www.ncbi.nlm.nih.gov/gene/?term=8295 "PAF350/400, PAF400, STAF40, TR-AP, Tra1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023289 829 CAPZA1 http://www.ncbi.nlm.nih.gov/gene/?term=829 "CAPPA1, CAPZ, CAZ1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023290 829 CAPZA1 http://www.ncbi.nlm.nih.gov/gene/?term=829 "CAPPA1, CAPZ, CAZ1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023291 8301 PICALM http://www.ncbi.nlm.nih.gov/gene/?term=8301 "CALM, CLTH, LAP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023292 8301 PICALM http://www.ncbi.nlm.nih.gov/gene/?term=8301 "CALM, CLTH, LAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023293 8303 SNN http://www.ncbi.nlm.nih.gov/gene/?term=8303 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023294 830 CAPZA2 http://www.ncbi.nlm.nih.gov/gene/?term=830 "CAPPA2, CAPZ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023295 830 CAPZA2 http://www.ncbi.nlm.nih.gov/gene/?term=830 "CAPPA2, CAPZ " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023296 8310 ACOX3 http://www.ncbi.nlm.nih.gov/gene/?term=8310 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023297 8313 AXIN2 http://www.ncbi.nlm.nih.gov/gene/?term=8313 "AXIL, ODCRCS " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023298 8314 BAP1 http://www.ncbi.nlm.nih.gov/gene/?term=8314 "HUCEP-13, UCHL2, hucep-6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023299 8314 BAP1 http://www.ncbi.nlm.nih.gov/gene/?term=8314 "HUCEP-13, UCHL2, hucep-6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023300 8317 CDC7 http://www.ncbi.nlm.nih.gov/gene/?term=8317 "CDC7L1, HsCDC7, Hsk1, huCDC7 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023301 8317 CDC7 http://www.ncbi.nlm.nih.gov/gene/?term=8317 "CDC7L1, HsCDC7, Hsk1, huCDC7 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023302 8317 CDC7 http://www.ncbi.nlm.nih.gov/gene/?term=8317 "CDC7L1, HsCDC7, Hsk1, huCDC7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023303 8318 CDC45 http://www.ncbi.nlm.nih.gov/gene/?term=8318 "CDC45LL2, PORC-PI-1, CDC45 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023304 8318 CDC45 http://www.ncbi.nlm.nih.gov/gene/?term=8318 "CDC45L, CDC45L2, PORC-PI-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023305 831 CAST http://www.ncbi.nlm.nih.gov/gene/?term=831 "BS-17, PLACK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023306 831 CAST http://www.ncbi.nlm.nih.gov/gene/?term=831 "BS-17, PLACK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023307 8321 FZD1 http://www.ncbi.nlm.nih.gov/gene/?term=8321 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023308 8322 FZD4 http://www.ncbi.nlm.nih.gov/gene/?term=8322 "CD344, EVR1, FEVRS, Fz-4, Fz4, FzE4, GPCR, hFz4, FZD4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023309 8322 FZD4 http://www.ncbi.nlm.nih.gov/gene/?term=8322 "CD344, EVR1, FEVRS, Fz-4, Fz4, FzE4, GPCR, hFz4, FZD4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023310 8322 FZD4 http://www.ncbi.nlm.nih.gov/gene/?term=8322 "CD344, EVR1, FEVRS, Fz-4, Fz4, FzE4, GPCR, hFz4, FZD4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023311 8323 FZD6 http://www.ncbi.nlm.nih.gov/gene/?term=8323 "FZ-6, FZ6, HFZ6, NDNC10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023312 8323 FZD6 http://www.ncbi.nlm.nih.gov/gene/?term=8323 "FZ-6, FZ6, HFZ6, NDNC10 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023313 8323 FZD6 http://www.ncbi.nlm.nih.gov/gene/?term=8323 "FZ-6, FZ6, HFZ6, NDNC10 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023314 8324 FZD7 http://www.ncbi.nlm.nih.gov/gene/?term=8324 FzE3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023315 8325 FZD8 http://www.ncbi.nlm.nih.gov/gene/?term=8325 "FZ-8, hFZ8 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023316 832990 BZO2H3 http://www.ncbi.nlm.nih.gov/gene/?term=832990 "AT5G28770, Arabidopsis thaliana basic leucine zipper 63, AtbZIP63, T32B20.4, T32B20_4 " mRNA Arabidopsis thaliana 23622241 Ribosome - RT-PCR "MiRNA target transcripts, such as AGO1, PHB, CSD2, SPL3, SCL6, and TCP4, showed a significant increase in membrane-bound polysomes (MBPs) association in the double mutant, whereas non-target transcripts such as UBQ5, eIF4A, ACTIN8, At2g01570, At5g28770, and At5g66770 were similarly distributed along membrane-bound polysomes (MBPs) fractions in wild type and amp1 lamp1 (Fig 6E). " RLID00023317 8329 HIST1H2AI http://www.ncbi.nlm.nih.gov/gene/?term=8329 "H2A/c, H2AFC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023318 832 CAPZB http://www.ncbi.nlm.nih.gov/gene/?term=832 "CAPB, CAPPB, CAPZ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023319 832 CAPZB http://www.ncbi.nlm.nih.gov/gene/?term=832 "CAPB, CAPPB, CAPZ " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023320 832 CAPZB http://www.ncbi.nlm.nih.gov/gene/?term=832 "CAPB, CAPPB, CAPZ " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023321 8334 HIST1H2AC http://www.ncbi.nlm.nih.gov/gene/?term=8334 "H2A/l, H2AFL, dJ221C16.4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023322 8334 HIST1H2AC http://www.ncbi.nlm.nih.gov/gene/?term=8334 "H2A/l, H2AFL, dJ221C16.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023323 83379 Klb http://www.ncbi.nlm.nih.gov/gene/?term=83379 "AV071179, betaKlotho " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023324 8337 HIST2H2AA3 http://www.ncbi.nlm.nih.gov/gene/?term=8337 "H2A, H2A.2, H2A/O, H2A/q, H2AFO, H2a-615, HIST2H2AA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023325 83383 Tfap4 http://www.ncbi.nlm.nih.gov/gene/?term=83383 "AI642933, AP-4, D930048N17Rik, Tcfap4, bHLHc41 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023326 8338 HIST2H2AC http://www.ncbi.nlm.nih.gov/gene/?term=8338 "H2A, H2A-GL101, H2A/q, H2AFQ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023327 833 CARS http://www.ncbi.nlm.nih.gov/gene/?term=833 "CARS1, CYSRS, MGC:11246 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023328 833 CARS http://www.ncbi.nlm.nih.gov/gene/?term=833 "CARS1, CYSRS, MGC:11246 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023329 8340 HIST1H2BL http://www.ncbi.nlm.nih.gov/gene/?term=8340 "H2B/c, H2BFC, dJ97D16.4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023330 8341 HIST1H2BN http://www.ncbi.nlm.nih.gov/gene/?term=8341 "H2B/d, H2BFD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023331 83435 Plekha3 http://www.ncbi.nlm.nih.gov/gene/?term=83435 FAPP1 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00023332 83439 TCF7L1 http://www.ncbi.nlm.nih.gov/gene/?term=83439 "TCF-3, TCF3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023333 83440 ADPGK http://www.ncbi.nlm.nih.gov/gene/?term=83440 "2610017G09Rik, ADP-GK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023334 83442 SH3BGRL3 http://www.ncbi.nlm.nih.gov/gene/?term=83442 "HEL-S-297, SH3BP-1, TIP-B1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023335 83442 SH3BGRL3 http://www.ncbi.nlm.nih.gov/gene/?term=83442 "HEL-S-297, SH3BP-1, TIP-B1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023336 83442 SH3BGRL3 http://www.ncbi.nlm.nih.gov/gene/?term=83442 "HEL-S-297, SH3BP-1, TIP-B1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023337 83443 SF3B5 http://www.ncbi.nlm.nih.gov/gene/?term=83443 "SF3b10, Ysf3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023338 83443 SF3B5 http://www.ncbi.nlm.nih.gov/gene/?term=83443 "SF3b10, Ysf3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023339 83444 INO80B http://www.ncbi.nlm.nih.gov/gene/?term=83444 "HMGA1L4, HMGIYL4, IES2, PAP-1BP, PAPA-1, PAPA1, ZNHIT4, hIes2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023340 83448 PUS7L http://www.ncbi.nlm.nih.gov/gene/?term=83448 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023341 83450 DRC3 http://www.ncbi.nlm.nih.gov/gene/?term=83450 "CFAP134, LRRC48 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023342 83451 ABHD11 http://www.ncbi.nlm.nih.gov/gene/?term=83451 "PP1226, WBSCR21 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023343 83451 ABHD11 http://www.ncbi.nlm.nih.gov/gene/?term=83451 "PP1226, WBSCR21 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023344 83452 RAB33B http://www.ncbi.nlm.nih.gov/gene/?term=83452 SMC2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023345 83452 RAB33B http://www.ncbi.nlm.nih.gov/gene/?term=83452 SMC2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023346 8345 HIST1H2BH http://www.ncbi.nlm.nih.gov/gene/?term=8345 "H2B/j, H2BFJ " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023347 8345 HIST1H2BH http://www.ncbi.nlm.nih.gov/gene/?term=8345 "H2B/j, H2BFJ " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023348 83460 EMC6 http://www.ncbi.nlm.nih.gov/gene/?term=83460 TMEM93 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023349 83460 EMC6 http://www.ncbi.nlm.nih.gov/gene/?term=83460 TMEM93 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023350 83461 CDCA3 http://www.ncbi.nlm.nih.gov/gene/?term=83461 "GRCC8, TOME-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023351 83463 MXD3 http://www.ncbi.nlm.nih.gov/gene/?term=83463 "BHLHC13, MAD3, MYX " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023352 83464 APH1B http://www.ncbi.nlm.nih.gov/gene/?term=83464 "APH-1B, PRO1328, PSFL, TAAV688 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023353 83478 ARHGAP24 http://www.ncbi.nlm.nih.gov/gene/?term=83478 "FILGAP, RC-GAP72, RCGAP72, p73, p73RhoGAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023354 83479 DDX59 http://www.ncbi.nlm.nih.gov/gene/?term=83479 "OFD5, ZNHIT5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023355 8347 HIST1H2BC http://www.ncbi.nlm.nih.gov/gene/?term=8347 "H2B.1, H2B/l, H2BFL, dJ221C16.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023356 8347 HIST1H2BC http://www.ncbi.nlm.nih.gov/gene/?term=8347 "H2B.1, H2B/l, H2BFL, dJ221C16.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023357 83480 PUS3 http://www.ncbi.nlm.nih.gov/gene/?term=83480 "2610020J05Rik, FKSG32 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023358 83486 Rbm5 http://www.ncbi.nlm.nih.gov/gene/?term=83486 D030069N10Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023359 83486 Rbm5 http://www.ncbi.nlm.nih.gov/gene/?term=83486 D030069N10Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00023360 83493 Sacm1l http://www.ncbi.nlm.nih.gov/gene/?term=83493 "SAC1, Sac1p, mKIAA0851 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023361 8349 HIST2H2BE http://www.ncbi.nlm.nih.gov/gene/?term=8349 "GL105, H2B, H2B.1, H2BFQ, H2BGL105, H2BQ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023362 8349 HIST2H2BE http://www.ncbi.nlm.nih.gov/gene/?term=8349 "GL105, H2B, H2B.1, H2BFQ, H2BGL105, H2BQ " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023363 83523 Impa1 http://www.ncbi.nlm.nih.gov/gene/?term=83523 Impa1-L mRNA Rattus norvegicus 20118926 Axon Neuron Fluorescence in situ hybridization "Although MyrdEGFP-Impa1-S mRNA was visible in the cell bodies and proximal axonal segments, the signal was much lower in distal axons. These data indicate that the 120-nt element within the 3�UTR of Impa1-L transcript is sufficient to target MyrdEGFP mRNA to distal axons. " RLID00023364 83523 Impa1 http://www.ncbi.nlm.nih.gov/gene/?term=83523 Impa1-L mRNA Rattus norvegicus 20118926 Cell body Neuron Fluorescence in situ hybridization "Although MyrdEGFP-Impa1-S mRNA was visible in the cell bodies and proximal axonal segments, the signal was much lower in distal axons. These data indicate that the 120-nt element within the 3�UTR of Impa1-L transcript is sufficient to target MyrdEGFP mRNA to distal axons. " RLID00023365 83532 Vdac3 http://www.ncbi.nlm.nih.gov/gene/?term=83532 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00023366 83540 NUF2 http://www.ncbi.nlm.nih.gov/gene/?term=83540 "CDCA1, CT106, NUF2R " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023367 83541 FAM110A http://www.ncbi.nlm.nih.gov/gene/?term=83541 "C20orf55, F10, bA371L19.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023368 83543 AIF1L http://www.ncbi.nlm.nih.gov/gene/?term=83543 "C9orf58, IBA2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023369 83544 DNAL1 http://www.ncbi.nlm.nih.gov/gene/?term=83544 "C14orf168, CILD16 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023370 83544 DNAL1 http://www.ncbi.nlm.nih.gov/gene/?term=83544 "C14orf168, CILD16 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023371 835478 CUC2 http://www.ncbi.nlm.nih.gov/gene/?term=835478 "AT5G53950, ANAC098, ATCUC2, Arabidopsis NAC domain containing protein 98, CUP-SHAPED COTYLEDON 2, K19P17.12, K19P17_12 " mRNA Arabidopsis thaliana 23622241 Ribosome - RT-PCR "MiRNA target transcripts, such as AGO1, PHB, CSD2, SPL3, SCL6, and TCP4, showed a significant increase in membrane-bound polysomes (MBPs) association in the double mutant, whereas non-target transcripts such as UBQ5, eIF4A, ACTIN8, At2g01570, At5g28770, and At5g66770 were similarly distributed along membrane-bound polysomes (MBPs) fractions in wild type and amp1 lamp1 (Fig 6E). " RLID00023372 83547 RILP http://www.ncbi.nlm.nih.gov/gene/?term=83547 PP10141 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023373 83547 RILP http://www.ncbi.nlm.nih.gov/gene/?term=83547 PP10141 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023374 83548 COG3 http://www.ncbi.nlm.nih.gov/gene/?term=83548 SEC34 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023375 83548 COG3 http://www.ncbi.nlm.nih.gov/gene/?term=83548 SEC34 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023376 83549 UCK1 http://www.ncbi.nlm.nih.gov/gene/?term=83549 URK1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023377 83549 UCK1 http://www.ncbi.nlm.nih.gov/gene/?term=83549 URK1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023378 83555 Tex13 http://www.ncbi.nlm.nih.gov/gene/?term=83555 "4933403J23Rikb, Tex13 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023379 83555 Tex13 http://www.ncbi.nlm.nih.gov/gene/?term=83555 "4933403J23Rikb, Tex13 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00023380 83564 Nlrp4c http://www.ncbi.nlm.nih.gov/gene/?term=83564 "Nalp-alpha, Nalp4c, Rnh2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023381 8356 HIST1H3J http://www.ncbi.nlm.nih.gov/gene/?term=8356 "H3/j, H3FJ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023382 83590 TMUB1 http://www.ncbi.nlm.nih.gov/gene/?term=83590 "C7orf21, DULP, SB144 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023383 83591 THAP2 http://www.ncbi.nlm.nih.gov/gene/?term=83591 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023384 83591 THAP2 http://www.ncbi.nlm.nih.gov/gene/?term=83591 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023385 83596 BCL2L12 http://www.ncbi.nlm.nih.gov/gene/?term=83596 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023386 835 CASP2 http://www.ncbi.nlm.nih.gov/gene/?term=835 "CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023387 835 CASP2 http://www.ncbi.nlm.nih.gov/gene/?term=835 "CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023388 83603 Elovl4 http://www.ncbi.nlm.nih.gov/gene/?term=83603 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023389 83604 TMEM47 http://www.ncbi.nlm.nih.gov/gene/?term=83604 "BCMP1, TM4SF10 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023390 83605 CCM2 http://www.ncbi.nlm.nih.gov/gene/?term=83605 "C7orf22, OSM, PP10187 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023391 83606 GUCD1 http://www.ncbi.nlm.nih.gov/gene/?term=83606 "C22orf13, LLN4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023392 83606 GUCD1 http://www.ncbi.nlm.nih.gov/gene/?term=83606 "C22orf13, LLN4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023393 83606 GUCD1 http://www.ncbi.nlm.nih.gov/gene/?term=83606 "C22orf13, LLN4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023394 83607 AMMECR1L http://www.ncbi.nlm.nih.gov/gene/?term=83607 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023395 83608 C18orf21 http://www.ncbi.nlm.nih.gov/gene/?term=83608 "HsT3108, PNAS-124, PNAS-131, XTP13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023396 83613 Nefl http://www.ncbi.nlm.nih.gov/gene/?term=83613 "NF-L, Nfl " mRNA Rattus norvegicus 9322162 Cell body Hippocampus In situ hybridization "The mRNAs for b-tubulin, neurofilament 68, and F1/GAP43 were restricted to the region of the cell body and very proximal dendrites in most neurons. " RLID00023397 83613 Nefl http://www.ncbi.nlm.nih.gov/gene/?term=83613 "NF-L, Nfl " mRNA Rattus norvegicus 9322162 Dendrite Hippocampus In situ hybridization "The mRNAs for b-tubulin, neurofilament 68, and F1/GAP43 were restricted to the region of the cell body and very proximal dendrites in most neurons. " RLID00023398 8362 HIST1H4K http://www.ncbi.nlm.nih.gov/gene/?term=8362 "H4/d, H4F2iii, H4FD, dJ160A22.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023399 8362 HIST1H4K http://www.ncbi.nlm.nih.gov/gene/?term=8362 "H4/d, H4F2iii, H4FD, dJ160A22.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023400 83633 Gabbr2 http://www.ncbi.nlm.nih.gov/gene/?term=83633 Gpr51 mRNA Rattus norvegicus 12081654 Dendrite Spinal neuron In situ hybridization "On spinal neurons both r1 and r2 mRNAs showed somatodendritic localization, extending out for >100 mm with punctate appearance especially in adult cells. Interestingly, a dendritic localization of the r1 and r2 mRNAs (Fig. 4C?, arrows) was observed. However, in several neuronsthe mRNAs for r1 or r2 could be found more than 100 mm away from the cell soma, indicating localization to distal dendrites (Table 1). " RLID00023401 83636 C19orf12 http://www.ncbi.nlm.nih.gov/gene/?term=83636 "NBIA3, NBIA4, SPG43 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023402 83636 C19orf12 http://www.ncbi.nlm.nih.gov/gene/?term=83636 "NBIA3, NBIA4, SPG43 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023403 83636 C19orf12 http://www.ncbi.nlm.nih.gov/gene/?term=83636 "NBIA3, NBIA4, SPG43 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023404 83636 C19orf12 http://www.ncbi.nlm.nih.gov/gene/?term=83636 "NBIA3, NBIA4, SPG43 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023405 83637 ZMIZ2 http://www.ncbi.nlm.nih.gov/gene/?term=83637 "NET27, TRAFIP20, ZIMP7, hZIMP7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023406 83638 C11orf68 http://www.ncbi.nlm.nih.gov/gene/?term=83638 "BLES03, P5326 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023407 83638 C11orf68 http://www.ncbi.nlm.nih.gov/gene/?term=83638 "BLES03, P5326 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023408 8363 HIST1H4J http://www.ncbi.nlm.nih.gov/gene/?term=8363 "H4/e, H4F2iv, H4FE, dJ160A22.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023409 8363 HIST1H4J http://www.ncbi.nlm.nih.gov/gene/?term=8363 "H4/e, H4F2iv, H4FE, dJ160A22.2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023410 8363 HIST1H4J http://www.ncbi.nlm.nih.gov/gene/?term=8363 "H4/e, H4F2iv, H4FE, dJ160A22.2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023411 83640 FAM103A1 http://www.ncbi.nlm.nih.gov/gene/?term=83640 "C15orf18, HsT19360, RAM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023412 83640 FAM103A1 http://www.ncbi.nlm.nih.gov/gene/?term=83640 "C15orf18, HsT19360, RAM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023413 8364 HIST1H4C http://www.ncbi.nlm.nih.gov/gene/?term=8364 "H4/g, H4FG, dJ221C16.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023414 8364 HIST1H4C http://www.ncbi.nlm.nih.gov/gene/?term=8364 "H4/g, H4FG, dJ221C16.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023415 8364 HIST1H4C http://www.ncbi.nlm.nih.gov/gene/?term=8364 "H4/g, H4FG, dJ221C16.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023416 8364 HIST1H4C http://www.ncbi.nlm.nih.gov/gene/?term=8364 "H4/g, H4FG, dJ221C16.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023417 83658 DYNLRB1 http://www.ncbi.nlm.nih.gov/gene/?term=83658 "BITH, BLP, DNCL2A, DNLC2A, ROBLD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023418 8365 HIST1H4H http://www.ncbi.nlm.nih.gov/gene/?term=8365 "H4/h, H4FH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023419 83660 TLN2 http://www.ncbi.nlm.nih.gov/gene/?term=83660 ILWEQ mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023420 83660 TLN2 http://www.ncbi.nlm.nih.gov/gene/?term=83660 ILWEQ mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023421 83661 MS4A8 http://www.ncbi.nlm.nih.gov/gene/?term=83661 "4SPAN4, CD20L5, MS4A4, MS4A8B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023422 83666 PARP9 http://www.ncbi.nlm.nih.gov/gene/?term=83666 "ARTD9, BAL, BAL1, MGC:7868 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023423 83667 SESN2 http://www.ncbi.nlm.nih.gov/gene/?term=83667 "HI95, SES2, SEST2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023424 83667 SESN2 http://www.ncbi.nlm.nih.gov/gene/?term=83667 "HI95, SES2, SEST2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023425 8366 HIST1H4B http://www.ncbi.nlm.nih.gov/gene/?term=8366 "H4/I, H4FI " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023426 8366 HIST1H4B http://www.ncbi.nlm.nih.gov/gene/?term=8366 "H4/I, H4FI " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023427 83673 Snhg1 http://www.ncbi.nlm.nih.gov/gene/?term=83673 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023428 83675 Bicc1 http://www.ncbi.nlm.nih.gov/gene/?term=83675 "Bic-C, bpk, jcpk " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00023429 8367 HIST1H4E http://www.ncbi.nlm.nih.gov/gene/?term=8367 "H4/j, H4FJ " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023430 836810 AT5G66770 http://www.ncbi.nlm.nih.gov/gene/?term=836810 "AT5G66770, MUD21.1, MUD21_1 " mRNA Arabidopsis thaliana 23622241 Ribosome - RT-PCR "MiRNA target transcripts, such as AGO1, PHB, CSD2, SPL3, SCL6, and TCP4, showed a significant increase in membrane-bound polysomes (MBPs) association in the double mutant, whereas non-target transcripts such as UBQ5, eIF4A, ACTIN8, At2g01570, At5g28770, and At5g66770 were similarly distributed along membrane-bound polysomes (MBPs) fractions in wild type and amp1 lamp1 (Fig 6E). " RLID00023431 83690 CRISPLD1 http://www.ncbi.nlm.nih.gov/gene/?term=83690 "CRISP-10, CRISP10, LCRISP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023432 83690 CRISPLD1 http://www.ncbi.nlm.nih.gov/gene/?term=83690 "CRISP-10, CRISP10, LCRISP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023433 83690 CRISPLD1 http://www.ncbi.nlm.nih.gov/gene/?term=83690 "CRISP-10, CRISP10, LCRISP1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023434 83692 CD99L2 http://www.ncbi.nlm.nih.gov/gene/?term=83692 "CD99B, MIC2L1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023435 83693 HSDL1 http://www.ncbi.nlm.nih.gov/gene/?term=83693 SDR12C3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023436 83693 HSDL1 http://www.ncbi.nlm.nih.gov/gene/?term=83693 SDR12C3 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023437 83693 HSDL1 http://www.ncbi.nlm.nih.gov/gene/?term=83693 SDR12C3 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023438 83694 RPS6KL1 http://www.ncbi.nlm.nih.gov/gene/?term=83694 RSKL2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023439 83695 RHNO1 http://www.ncbi.nlm.nih.gov/gene/?term=83695 "C12orf32, HKMT1188, RHINO " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023440 83695 RHNO1 http://www.ncbi.nlm.nih.gov/gene/?term=83695 "C12orf32, HKMT1188, RHINO " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023441 83695 RHNO1 http://www.ncbi.nlm.nih.gov/gene/?term=83695 "C12orf32, HKMT1188, RHINO " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023442 83695 RHNO1 http://www.ncbi.nlm.nih.gov/gene/?term=83695 "C12orf32, HKMT1188, RHINO " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023443 83699 SH3BGRL2 http://www.ncbi.nlm.nih.gov/gene/?term=83699 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023444 836 CASP3 http://www.ncbi.nlm.nih.gov/gene/?term=836 "CPP32, CPP32B, SCA-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023445 836 CASP3 http://www.ncbi.nlm.nih.gov/gene/?term=836 "CPP32, CPP32B, SCA-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023446 83701 Srrt http://www.ncbi.nlm.nih.gov/gene/?term=83701 "2810019G02Rik, ASR2A, ASR2B, ASR2C, ASR2D, Ars2, Asr2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023447 83706 FERMT3 http://www.ncbi.nlm.nih.gov/gene/?term=83706 "KIND3, MIG-2, MIG2B, UNC112C, URP2, URP2SF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023448 83707 TRPT1 http://www.ncbi.nlm.nih.gov/gene/?term=83707 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023449 83715 ESPN http://www.ncbi.nlm.nih.gov/gene/?term=83715 "DFNB36, LP2654 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023450 83719 YPEL3 http://www.ncbi.nlm.nih.gov/gene/?term=83719 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023451 8372 HYAL3 http://www.ncbi.nlm.nih.gov/gene/?term=8372 "HYAL-3, LUCA-3, LUCA3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023452 8372 HYAL3 http://www.ncbi.nlm.nih.gov/gene/?term=8372 "HYAL-3, LUCA-3, LUCA3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023453 83732 RIOK1 http://www.ncbi.nlm.nih.gov/gene/?term=83732 "AD034, RRP10, bA288G3.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023454 83734 ATG10 http://www.ncbi.nlm.nih.gov/gene/?term=83734 "APG10, APG10L, pp12616 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023455 83734 ATG10 http://www.ncbi.nlm.nih.gov/gene/?term=83734 "APG10, APG10L, pp12616 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023456 83737 ITCH http://www.ncbi.nlm.nih.gov/gene/?term=83737 "ADMFD, AIF4, AIP4, NAPP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023457 83742 MARVELD1 http://www.ncbi.nlm.nih.gov/gene/?term=83742 "GB14, MARVD1, MRVLDC1, bA548K23.8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023458 83743 GRWD1 http://www.ncbi.nlm.nih.gov/gene/?term=83743 "CDW4, GRWD, RRB1, WDR28 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023459 83743 GRWD1 http://www.ncbi.nlm.nih.gov/gene/?term=83743 "CDW4, GRWD, RRB1, WDR28 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023460 83743 GRWD1 http://www.ncbi.nlm.nih.gov/gene/?term=83743 "CDW4, GRWD, RRB1, WDR28 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023461 83743 GRWD1 http://www.ncbi.nlm.nih.gov/gene/?term=83743 "CDW4, GRWD, RRB1, WDR28 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023462 83746 L3MBTL2 http://www.ncbi.nlm.nih.gov/gene/?term=83746 "H-l(3)mbt-l, L3MBT " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023463 83752 LONP2 http://www.ncbi.nlm.nih.gov/gene/?term=83752 "LONP, LONPL " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023464 83752 LONP2 http://www.ncbi.nlm.nih.gov/gene/?term=83752 "LONP, LONPL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023465 83752 LONP2 http://www.ncbi.nlm.nih.gov/gene/?term=83752 "LONP, LONPL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023466 83786 FRMD8 http://www.ncbi.nlm.nih.gov/gene/?term=83786 FKSG44 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023467 83786 FRMD8 http://www.ncbi.nlm.nih.gov/gene/?term=83786 FKSG44 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023468 83786 FRMD8 http://www.ncbi.nlm.nih.gov/gene/?term=83786 FKSG44 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023469 83786 FRMD8 http://www.ncbi.nlm.nih.gov/gene/?term=83786 FKSG44 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023470 83787 ARMC10 http://www.ncbi.nlm.nih.gov/gene/?term=83787 "PNAS-112, PNAS112, PSEC0198, SVH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023471 83787 ARMC10 http://www.ncbi.nlm.nih.gov/gene/?term=83787 "PNAS-112, PNAS112, PSEC0198, SVH " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023472 83796 Smarcd2 http://www.ncbi.nlm.nih.gov/gene/?term=83796 "AW322457, Baf60b " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00023473 83797 Smarcd1 http://www.ncbi.nlm.nih.gov/gene/?term=83797 "AA407987, Baf60a, D15Kz1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023474 8379 MAD1L1 http://www.ncbi.nlm.nih.gov/gene/?term=8379 "MAD1, PIG9, TP53I9, TXBP181 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023475 837 CASP4 http://www.ncbi.nlm.nih.gov/gene/?term=837 "ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023476 83813 Tnk1 http://www.ncbi.nlm.nih.gov/gene/?term=83813 "Kos1a, Tnk1b, Tnk1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00023477 83815 Cenpq http://www.ncbi.nlm.nih.gov/gene/?term=83815 2610528M18Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023478 8382 NME5 http://www.ncbi.nlm.nih.gov/gene/?term=8382 "NM23-H5, NM23H5, RSPH23 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023479 83834 Nrn1 http://www.ncbi.nlm.nih.gov/gene/?term=83834 Nrn mRNA Rattus norvegicus 23966695 Axon Sensory neuron RT-PCR "Neuritin mRNA shifts from cell body to axon predominantly after nerve crush injury, suggesting that it encodes a growth-associated protein. Consistent with this, overexpression of neuritin increases axon growth but only when its mRNA localizes into the axons. " RLID00023480 83834 Nrn1 http://www.ncbi.nlm.nih.gov/gene/?term=83834 Nrn mRNA Rattus norvegicus 26180210 Axon Spinal cord In situ hybridization "By quantitative fluorescent in situ hybridization combined with immunofluorescence to unambiguously distinguish intra-axonal mRNAs, we show that regenerating spinal cord axons contain β-actin, GAP-43, Neuritin, Reg3a, Hamp, and Importin β1 mRNAs. " RLID00023481 83834 Nrn1 http://www.ncbi.nlm.nih.gov/gene/?term=83834 Nrn mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00023482 83849 SYT15 http://www.ncbi.nlm.nih.gov/gene/?term=83849 "CHR10SYT, sytXV " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023483 83849 SYT15 http://www.ncbi.nlm.nih.gov/gene/?term=83849 "CHR10SYT, sytXV " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023484 83852 SETDB2 http://www.ncbi.nlm.nih.gov/gene/?term=83852 "C13orf4, CLLD8, CLLL8, KMT1F " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023485 83855 KLF16 http://www.ncbi.nlm.nih.gov/gene/?term=83855 "BTEB4, DRRF, NSLP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023486 83857 TMTC1 http://www.ncbi.nlm.nih.gov/gene/?term=83857 "ARG99, OLF, TMTC1A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023487 83858 ATAD3B http://www.ncbi.nlm.nih.gov/gene/?term=83858 "AAA-TOB3, TOB3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023488 83860 TAF3 http://www.ncbi.nlm.nih.gov/gene/?term=83860 "TAF140, TAFII-140, TAFII140 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023489 83862 TMEM120A http://www.ncbi.nlm.nih.gov/gene/?term=83862 "NET29, TMPIT " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023490 83874 TBC1D10A http://www.ncbi.nlm.nih.gov/gene/?term=83874 "EPI64, TBC1D10, dJ130H16.1, dJ130H16.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023491 83876 MRO http://www.ncbi.nlm.nih.gov/gene/?term=83876 "B29, C18orf3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023492 83876 MRO http://www.ncbi.nlm.nih.gov/gene/?term=83876 "B29, C18orf3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023493 83877 TM2D2 http://www.ncbi.nlm.nih.gov/gene/?term=83877 BLP1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023494 83878 USHBP1 http://www.ncbi.nlm.nih.gov/gene/?term=83878 "AIEBP, MCC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023495 83879 CDCA7 http://www.ncbi.nlm.nih.gov/gene/?term=83879 JPO1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023496 83879 CDCA7 http://www.ncbi.nlm.nih.gov/gene/?term=83879 JPO1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023497 83887 TTLL2 http://www.ncbi.nlm.nih.gov/gene/?term=83887 "C6orf104, NYD-TSPG, dJ366N23.3 " mRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00023498 83890 SPATA9 http://www.ncbi.nlm.nih.gov/gene/?term=83890 NYD-SP16 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023499 83891 SNX25 http://www.ncbi.nlm.nih.gov/gene/?term=83891 "MSTP043, SBBI31 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023500 83892 KCTD10 http://www.ncbi.nlm.nih.gov/gene/?term=83892 "BTBD28, MSTP028, ULRO61, hBACURD3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023501 83892 KCTD10 http://www.ncbi.nlm.nih.gov/gene/?term=83892 "BTBD28, MSTP028, ULRO61, hBACURD3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023502 83892 KCTD10 http://www.ncbi.nlm.nih.gov/gene/?term=83892 "BTBD28, MSTP028, ULRO61, hBACURD3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023503 83892 KCTD10 http://www.ncbi.nlm.nih.gov/gene/?term=83892 "BTBD28, MSTP028, ULRO61, hBACURD3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023504 83903 GSG2 http://www.ncbi.nlm.nih.gov/gene/?term=83903 HASPIN mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023505 83921 Tmem2 http://www.ncbi.nlm.nih.gov/gene/?term=83921 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023506 83925 Trps1 http://www.ncbi.nlm.nih.gov/gene/?term=83925 "AI115454, AI447310, D15Ertd586e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023507 83925 Trps1 http://www.ncbi.nlm.nih.gov/gene/?term=83925 "AI115454, AI447310, D15Ertd586e " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00023508 83931 STK40 http://www.ncbi.nlm.nih.gov/gene/?term=83931 "SHIK, SgK495 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023509 83931 STK40 http://www.ncbi.nlm.nih.gov/gene/?term=83931 "SHIK, SgK495 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023510 83933 HDAC10 http://www.ncbi.nlm.nih.gov/gene/?term=83933 HD10 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023511 83937 RASSF4 http://www.ncbi.nlm.nih.gov/gene/?term=83937 AD037 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023512 83939 EIF2A http://www.ncbi.nlm.nih.gov/gene/?term=83939 "CDA02, EIF-2A, MST089, MSTP004, MSTP089 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023513 83939 EIF2A http://www.ncbi.nlm.nih.gov/gene/?term=83939 "CDA02, EIF-2A, MST089, MSTP004, MSTP089 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023514 83939 EIF2A http://www.ncbi.nlm.nih.gov/gene/?term=83939 "CDA02, EIF-2A, MST089, MSTP004, MSTP089 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023515 83941 TM2D1 http://www.ncbi.nlm.nih.gov/gene/?term=83941 BBP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023516 83941 TM2D1 http://www.ncbi.nlm.nih.gov/gene/?term=83941 BBP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023517 83943 IMMP2L http://www.ncbi.nlm.nih.gov/gene/?term=83943 "IMMP2L-IT1, IMP2, IMP2-LIKE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023518 83946 Phip http://www.ncbi.nlm.nih.gov/gene/?term=83946 "2810004D21Rik, 4632404O06Rik, Ndrp, Wdr11 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023519 8394 PIP5K1A http://www.ncbi.nlm.nih.gov/gene/?term=8394 mRNA Homo sapiens 23452202 Ribosome Lung fibroblast qRT-PCR "Cell spreading is also associated with an increase in the association of PIP5K1a mRNA with ribosomes (Table 1), suggesting that localized protein synthesis could modulate PtdIns(3,4,5)P3 levels, facilitating mTOR activation and WAVE complex clustering. " RLID00023520 8394 PIP5K1A http://www.ncbi.nlm.nih.gov/gene/?term=8394 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023521 8395 PIP5K1B http://www.ncbi.nlm.nih.gov/gene/?term=8395 "MSS4, STM7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023522 83962 Btbd1 http://www.ncbi.nlm.nih.gov/gene/?term=83962 1190005H08Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00023523 83964 Jam3 http://www.ncbi.nlm.nih.gov/gene/?term=83964 "1110002N23Rik, JAM-3, JAM-C, Jcam3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023524 83982 IFI27L2 http://www.ncbi.nlm.nih.gov/gene/?term=83982 "FAM14A, ISG12B, TLH29 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023525 83983 TSSK6 http://www.ncbi.nlm.nih.gov/gene/?term=83983 "CT72, FKSG82, SSTK, TSSK4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023526 83986 FAM234A http://www.ncbi.nlm.nih.gov/gene/?term=83986 "C16orf9, ITFG3, gs19 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023527 83987 CCDC8 http://www.ncbi.nlm.nih.gov/gene/?term=83987 "3M3, PPP1R20, p90 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023528 83987 CCDC8 http://www.ncbi.nlm.nih.gov/gene/?term=83987 "3M3, PPP1R20, p90 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023529 83987 CCDC8 http://www.ncbi.nlm.nih.gov/gene/?term=83987 "3M3, PPP1R20, p90 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023530 83988 NCALD http://www.ncbi.nlm.nih.gov/gene/?term=83988 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023531 83989 FAM172A http://www.ncbi.nlm.nih.gov/gene/?term=83989 C5orf21 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023532 83989 FAM172A http://www.ncbi.nlm.nih.gov/gene/?term=83989 C5orf21 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023533 83990 BRIP1 http://www.ncbi.nlm.nih.gov/gene/?term=83990 "BACH1, FANCJ, OF " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023534 83998 REG4 http://www.ncbi.nlm.nih.gov/gene/?term=83998 "GISP, REG-IV, RELP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023535 83998 REG4 http://www.ncbi.nlm.nih.gov/gene/?term=83998 "GISP, REG-IV, RELP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023536 83999 KREMEN1 http://www.ncbi.nlm.nih.gov/gene/?term=83999 "KREMEN, KRM1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023537 8399 PLA2G10 http://www.ncbi.nlm.nih.gov/gene/?term=8399 "GXPLA2, GXSPLA2, SPLA2, sPLA2-X " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023538 8399 PLA2G10 http://www.ncbi.nlm.nih.gov/gene/?term=8399 "GXPLA2, GXSPLA2, SPLA2, sPLA2-X " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023539 839 CASP6 http://www.ncbi.nlm.nih.gov/gene/?term=839 MCH2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023540 839 CASP6 http://www.ncbi.nlm.nih.gov/gene/?term=839 MCH2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023541 839 CASP6 http://www.ncbi.nlm.nih.gov/gene/?term=839 MCH2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023542 84000 TMPRSS13 http://www.ncbi.nlm.nih.gov/gene/?term=84000 "MSP, MSPL, MSPS, TMPRSS11 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023543 84002 B3GNT5 http://www.ncbi.nlm.nih.gov/gene/?term=84002 "B3GN-T5, beta3Gn-T5 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023544 84002 B3GNT5 http://www.ncbi.nlm.nih.gov/gene/?term=84002 "B3GN-T5, beta3Gn-T5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023545 84027 Gsk3b http://www.ncbi.nlm.nih.gov/gene/?term=84027 mRNA Rattus norvegicus 24898526 Axon Spinal motoneuron In situ hybridization|qRT-PCR "In cultured cortical neurons which do not store glycogen but nevertheless express glycogen synthase, the GS mRNA is also subject to axonal and dendritic localization. In spinal motoneurons and trigeminal neurons in situ, however, the mRNAs could only be demonstrated in the neuronal somata but not in the nerves. " RLID00023546 84027 Gsk3b http://www.ncbi.nlm.nih.gov/gene/?term=84027 mRNA Rattus norvegicus 24898526 Dendrite Spinal motoneuron In situ hybridization|qRT-PCR "In cultured cortical neurons which do not store glycogen but nevertheless express glycogen synthase, the GS mRNA is also subject to axonal and dendritic localization. In spinal motoneurons and trigeminal neurons in situ, however, the mRNAs could only be demonstrated in the neuronal somata but not in the nerves. " RLID00023547 8402 SLC25A11 http://www.ncbi.nlm.nih.gov/gene/?term=8402 "OGC, SLC20A4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023548 8402 SLC25A11 http://www.ncbi.nlm.nih.gov/gene/?term=8402 "OGC, SLC20A4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023549 84033 OBSCN http://www.ncbi.nlm.nih.gov/gene/?term=84033 "ARHGEF30, UNC89 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023550 84034 EMILIN2 http://www.ncbi.nlm.nih.gov/gene/?term=84034 "EMILIN-2, FOAP-10 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023551 8404 SPARCL1 http://www.ncbi.nlm.nih.gov/gene/?term=8404 "MAST 9, MAST9, PIG33, SC1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023552 84056 KATNAL1 http://www.ncbi.nlm.nih.gov/gene/?term=84056 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023553 84056 KATNAL1 http://www.ncbi.nlm.nih.gov/gene/?term=84056 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023554 84056 KATNAL1 http://www.ncbi.nlm.nih.gov/gene/?term=84056 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023555 84059 ADGRV1 http://www.ncbi.nlm.nih.gov/gene/?term=84059 "FEB4, GPR98, MASS1, USH2B, USH2C, VLGR1, VLGR1b " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023556 8405 SPOP http://www.ncbi.nlm.nih.gov/gene/?term=8405 "BTBD32, TEF2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023557 8405 SPOP http://www.ncbi.nlm.nih.gov/gene/?term=8405 "BTBD32, TEF2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023558 8405 SPOP http://www.ncbi.nlm.nih.gov/gene/?term=8405 "BTBD32, TEF2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023559 8405 SPOP http://www.ncbi.nlm.nih.gov/gene/?term=8405 "BTBD32, TEF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023560 84060 RBM48 http://www.ncbi.nlm.nih.gov/gene/?term=84060 "C7orf64, HSPC304, MGC16142 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023561 84060 RBM48 http://www.ncbi.nlm.nih.gov/gene/?term=84060 "C7orf64, HSPC304, MGC16142 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023562 84061 MAGT1 http://www.ncbi.nlm.nih.gov/gene/?term=84061 "IAP, MRX95, OST3B, PRO0756, XMEN, bA217H1.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023563 84061 MAGT1 http://www.ncbi.nlm.nih.gov/gene/?term=84061 "IAP, MRX95, OST3B, PRO0756, XMEN, bA217H1.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023564 84061 MAGT1 http://www.ncbi.nlm.nih.gov/gene/?term=84061 "IAP, MRX95, OST3B, PRO0756, XMEN, bA217H1.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023565 84061 MAGT1 http://www.ncbi.nlm.nih.gov/gene/?term=84061 "IAP, MRX95, OST3B, PRO0756, XMEN, bA217H1.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023566 84064 HDHD2 http://www.ncbi.nlm.nih.gov/gene/?term=84064 "3110052N05Rik, HEL-S-301 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023567 84065 TMEM222 http://www.ncbi.nlm.nih.gov/gene/?term=84065 C1orf160 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023568 84067 FAM160A2 http://www.ncbi.nlm.nih.gov/gene/?term=84067 C11orf56 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023569 84068 SLC10A7 http://www.ncbi.nlm.nih.gov/gene/?term=84068 "C4orf13, P7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023570 84078 KBTBD7 http://www.ncbi.nlm.nih.gov/gene/?term=84078 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023571 84079 ANKRD27 http://www.ncbi.nlm.nih.gov/gene/?term=84079 "PP12899, VARP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023572 84079 ANKRD27 http://www.ncbi.nlm.nih.gov/gene/?term=84079 "PP12899, VARP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023573 84079 ANKRD27 http://www.ncbi.nlm.nih.gov/gene/?term=84079 "PP12899, VARP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023574 8407 TAGLN2 http://www.ncbi.nlm.nih.gov/gene/?term=8407 HA1756 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023575 8407 TAGLN2 http://www.ncbi.nlm.nih.gov/gene/?term=8407 HA1756 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023576 84080 ENKD1 http://www.ncbi.nlm.nih.gov/gene/?term=84080 "C16orf48, DAKV6410 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023577 84081 NSRP1 http://www.ncbi.nlm.nih.gov/gene/?term=84081 "CCDC55, HSPC095, NSrp70 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023578 8408 ULK1 http://www.ncbi.nlm.nih.gov/gene/?term=8408 "ATG1, ATG1A, UNC51, Unc51.1, hATG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023579 84092 Usp8 http://www.ncbi.nlm.nih.gov/gene/?term=84092 "AI574262, AW557536, Ubpy, mKIAA0055 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023580 8409 UXT http://www.ncbi.nlm.nih.gov/gene/?term=8409 "ART-27, STAP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023581 8409 UXT http://www.ncbi.nlm.nih.gov/gene/?term=8409 "ART-27, STAP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023582 8409 UXT http://www.ncbi.nlm.nih.gov/gene/?term=8409 "ART-27, STAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023583 840 CASP7 http://www.ncbi.nlm.nih.gov/gene/?term=840 "CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023584 840 CASP7 http://www.ncbi.nlm.nih.gov/gene/?term=840 "CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023585 840 CASP7 http://www.ncbi.nlm.nih.gov/gene/?term=840 "CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023586 84101 USP44 http://www.ncbi.nlm.nih.gov/gene/?term=84101 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023587 84105 PCBD2 http://www.ncbi.nlm.nih.gov/gene/?term=84105 "DCOH2, DCOHM, PHS2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023588 84105 PCBD2 http://www.ncbi.nlm.nih.gov/gene/?term=84105 "DCOH2, DCOHM, PHS2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023589 84109 QRFPR http://www.ncbi.nlm.nih.gov/gene/?term=84109 "AQ27, GPR103, SP9155 " mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00023590 8411 EEA1 http://www.ncbi.nlm.nih.gov/gene/?term=8411 "MST105, MSTP105, ZFYVE2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023591 841262 AGO1 http://www.ncbi.nlm.nih.gov/gene/?term=841262 "AT1G48410, ARGONAUTE 1, T1N15.2, T1N15_2 " mRNA Arabidopsis thaliana 23622241 Ribosome - RT-PCR "MiRNA target transcripts, such as AGO1, PHB, CSD2, SPL3, SCL6, and TCP4, showed a significant increase in membrane-bound polysomes (MBPs) association in the double mutant, whereas non-target transcripts such as UBQ5, eIF4A, ACTIN8, At2g01570, At5g28770, and At5g66770 were similarly distributed along membrane-bound polysomes (MBPs) fractions in wild type and amp1 lamp1 (Fig 6E). " RLID00023592 84128 WDR75 http://www.ncbi.nlm.nih.gov/gene/?term=84128 "NET16, UTP17 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023593 84131 CEP78 http://www.ncbi.nlm.nih.gov/gene/?term=84131 "C9orf81, IP63 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023594 84132 USP42 http://www.ncbi.nlm.nih.gov/gene/?term=84132 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023595 84132 USP42 http://www.ncbi.nlm.nih.gov/gene/?term=84132 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023596 84133 ZNRF3 http://www.ncbi.nlm.nih.gov/gene/?term=84133 "BK747E2.3, RNF203 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023597 84133 ZNRF3 http://www.ncbi.nlm.nih.gov/gene/?term=84133 "BK747E2.3, RNF203 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023598 84133 ZNRF3 http://www.ncbi.nlm.nih.gov/gene/?term=84133 "BK747E2.3, RNF203 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023599 84133 ZNRF3 http://www.ncbi.nlm.nih.gov/gene/?term=84133 "BK747E2.3, RNF203 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023600 841347 ACT8 http://www.ncbi.nlm.nih.gov/gene/?term=841347 "AT1G49240, F27J15.1, F27J15_1, actin 8 " mRNA Arabidopsis thaliana 23622241 Ribosome - RT-PCR "MiRNA target transcripts, such as AGO1, PHB, CSD2, SPL3, SCL6, and TCP4, showed a significant increase in membrane-bound polysomes (MBPs) association in the double mutant, whereas non-target transcripts such as UBQ5, eIF4A, ACTIN8, At2g01570, At5g28770, and At5g66770 were similarly distributed along membrane-bound polysomes (MBPs) fractions in wild type and amp1 lamp1 (Fig 6E). " RLID00023601 84134 TOMM40L http://www.ncbi.nlm.nih.gov/gene/?term=84134 TOMM40B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023602 84134 TOMM40L http://www.ncbi.nlm.nih.gov/gene/?term=84134 TOMM40B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023603 84135 UTP15 http://www.ncbi.nlm.nih.gov/gene/?term=84135 NET21 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023604 84135 UTP15 http://www.ncbi.nlm.nih.gov/gene/?term=84135 NET21 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023605 84138 SLC7A6OS http://www.ncbi.nlm.nih.gov/gene/?term=84138 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023606 84138 SLC7A6OS http://www.ncbi.nlm.nih.gov/gene/?term=84138 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023607 84140 FAM161A http://www.ncbi.nlm.nih.gov/gene/?term=84140 RP28 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023608 84140 FAM161A http://www.ncbi.nlm.nih.gov/gene/?term=84140 RP28 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023609 84144 SYDE2 http://www.ncbi.nlm.nih.gov/gene/?term=84144 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023610 84144 SYDE2 http://www.ncbi.nlm.nih.gov/gene/?term=84144 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023611 84146 ZNF644 http://www.ncbi.nlm.nih.gov/gene/?term=84146 "BM-005, MYP21, NatF, ZEP-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023612 84148 KAT8 http://www.ncbi.nlm.nih.gov/gene/?term=84148 "MOF, MYST1, ZC2HC8, hMOF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023613 84148 KAT8 http://www.ncbi.nlm.nih.gov/gene/?term=84148 "MOF, MYST1, ZC2HC8, hMOF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023614 84152 PPP1R1B http://www.ncbi.nlm.nih.gov/gene/?term=84152 "DARPP-32, DARPP32 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023615 84153 RNASEH2C http://www.ncbi.nlm.nih.gov/gene/?term=84153 "AGS3, AYP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023616 84154 RPF2 http://www.ncbi.nlm.nih.gov/gene/?term=84154 "BXDC1, bA397G5.4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023617 84159 ARID5B http://www.ncbi.nlm.nih.gov/gene/?term=84159 "DESRT, MRF-2, MRF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023618 84162 KIAA1109 http://www.ncbi.nlm.nih.gov/gene/?term=84162 "FSA, Tweek " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023619 84162 KIAA1109 http://www.ncbi.nlm.nih.gov/gene/?term=84162 "FSA, Tweek " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023620 84163 GTF2IRD2 http://www.ncbi.nlm.nih.gov/gene/?term=84163 "FP630 alpha, GTF2IRD2A, GTF2IRD2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023621 84163 GTF2IRD2 http://www.ncbi.nlm.nih.gov/gene/?term=84163 "FP630 alpha, GTF2IRD2A, GTF2IRD2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023622 84164 ASCC2 http://www.ncbi.nlm.nih.gov/gene/?term=84164 "ASC1p100, p100 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023623 84164 ASCC2 http://www.ncbi.nlm.nih.gov/gene/?term=84164 "ASC1p100, p100 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023624 84166 NLRC5 http://www.ncbi.nlm.nih.gov/gene/?term=84166 "CLR16.1, NOD27, NOD4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023625 84167 C19orf44 http://www.ncbi.nlm.nih.gov/gene/?term=84167 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023626 84168 ANTXR1 http://www.ncbi.nlm.nih.gov/gene/?term=84168 "ATR, GAPO, TEM8 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023627 84172 POLR1B http://www.ncbi.nlm.nih.gov/gene/?term=84172 "RPA135, RPA2, Rpo1-2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023628 84173 ELMOD3 http://www.ncbi.nlm.nih.gov/gene/?term=84173 "DFNB88, LST3, RBED1, RBM29 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023629 84174 SLA2 http://www.ncbi.nlm.nih.gov/gene/?term=84174 "C20orf156, MARS, SLAP-2, SLAP2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023630 84174 SLA2 http://www.ncbi.nlm.nih.gov/gene/?term=84174 "C20orf156, MARS, SLAP-2, SLAP2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023631 84179 MFSD7 http://www.ncbi.nlm.nih.gov/gene/?term=84179 LP2561 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023632 8417 STX7 http://www.ncbi.nlm.nih.gov/gene/?term=8417 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023633 84181 CHD6 http://www.ncbi.nlm.nih.gov/gene/?term=84181 "CHD-6, CHD5, RIGB " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023634 84181 CHD6 http://www.ncbi.nlm.nih.gov/gene/?term=84181 "CHD-6, CHD5, RIGB " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023635 84181 CHD6 http://www.ncbi.nlm.nih.gov/gene/?term=84181 "CHD-6, CHD5, RIGB " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023636 841868 EIF4A-2 http://www.ncbi.nlm.nih.gov/gene/?term=841868 "AT1G54270, F20D21.9, F20D21_9, eif4a-2 " mRNA Arabidopsis thaliana 23622241 Ribosome - RT-PCR "MiRNA target transcripts, such as AGO1, PHB, CSD2, SPL3, SCL6, and TCP4, showed a significant increase in membrane-bound polysomes (MBPs) association in the double mutant, whereas non-target transcripts such as UBQ5, eIF4A, ACTIN8, At2g01570, At5g28770, and At5g66770 were similarly distributed along membrane-bound polysomes (MBPs) fractions in wild type and amp1 lamp1 (Fig 6E). " RLID00023637 84186 ZCCHC7 http://www.ncbi.nlm.nih.gov/gene/?term=84186 "AIR1, HSPC086 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023638 84187 TMEM164 http://www.ncbi.nlm.nih.gov/gene/?term=84187 bB360B22.3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023639 84188 FAR1 http://www.ncbi.nlm.nih.gov/gene/?term=84188 "MLSTD2, PFCRD, SDR10E1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023640 84189 SLITRK6 http://www.ncbi.nlm.nih.gov/gene/?term=84189 DFNMYP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023641 84191 FAM96A http://www.ncbi.nlm.nih.gov/gene/?term=84191 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023642 84191 FAM96A http://www.ncbi.nlm.nih.gov/gene/?term=84191 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023643 84193 SETD3 http://www.ncbi.nlm.nih.gov/gene/?term=84193 C14orf154 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023644 84193 SETD3 http://www.ncbi.nlm.nih.gov/gene/?term=84193 C14orf154 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023645 84196 USP48 http://www.ncbi.nlm.nih.gov/gene/?term=84196 "RAP1GA1, USP31 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023646 84196 USP48 http://www.ncbi.nlm.nih.gov/gene/?term=84196 "RAP1GA1, USP31 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023647 84197 POMK http://www.ncbi.nlm.nih.gov/gene/?term=84197 "MDDGA12, MDDGC12, SGK196 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023648 841 CASP8 http://www.ncbi.nlm.nih.gov/gene/?term=841 "ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023649 841 CASP8 http://www.ncbi.nlm.nih.gov/gene/?term=841 "ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023650 841 CASP8 http://www.ncbi.nlm.nih.gov/gene/?term=841 "ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023651 8420 SNHG3 http://www.ncbi.nlm.nih.gov/gene/?term=8420 "NCRNA00014, RNU17C, RNU17D, U17HG, U17HG-A, U17HG-AB " lncRNA Homo sapiens 9671460 Cytoplasm HeLa cell Northern blot "We investigated the cellular localization of the U17HG RNA. Cell fractionation experiments indicated that U17HG RNA is enriched in the cytoplasm (Fig.5A), similar to UHG RNA, another noncoding snoRNA host having no protein-coding potential (Fig.5B). As expected, U17 snoRNA, used as a control, was found mainly in the nuclear fraction (Fig.5C). " RLID00023652 84219 WDR24 http://www.ncbi.nlm.nih.gov/gene/?term=84219 "C16orf21, JFP7 " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00023653 84219 WDR24 http://www.ncbi.nlm.nih.gov/gene/?term=84219 "C16orf21, JFP7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023654 84219 WDR24 http://www.ncbi.nlm.nih.gov/gene/?term=84219 "C16orf21, JFP7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023655 84220 RGPD5 http://www.ncbi.nlm.nih.gov/gene/?term=84220 "BS-63, BS63, HEL161, RGP5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023656 84220 RGPD5 http://www.ncbi.nlm.nih.gov/gene/?term=84220 "BS-63, BS63, HEL161, RGP5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023657 84221 SPATC1L http://www.ncbi.nlm.nih.gov/gene/?term=84221 C21orf56 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023658 84222 TMEM191A http://www.ncbi.nlm.nih.gov/gene/?term=84222 TMEM191AP lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023659 84225 ZMYND15 http://www.ncbi.nlm.nih.gov/gene/?term=84225 SPGF14 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023660 84230 LRRC8C http://www.ncbi.nlm.nih.gov/gene/?term=84230 "AD158, FAD158 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023661 84231 TRAF7 http://www.ncbi.nlm.nih.gov/gene/?term=84231 "RFWD1, RNF119 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023662 84232 MAF1 http://www.ncbi.nlm.nih.gov/gene/?term=84232 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023663 84232 MAF1 http://www.ncbi.nlm.nih.gov/gene/?term=84232 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023664 84233 TMEM126A http://www.ncbi.nlm.nih.gov/gene/?term=84233 OPA7 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023665 84233 TMEM126A http://www.ncbi.nlm.nih.gov/gene/?term=84233 OPA7 mRNA Homo sapiens 23500070 Mitochondrion SH-SY5Y cell Fluorescence in situ hybridization "TMEM126A mRNAs are strongly enriched in the vicinity of mitochondria and encode an inner mitochondrial membrane associated cristae protein. TMEM126A is a mitochondrial located mRNA (MLR) that may be translated in the mitochondrial surface and the protein is subsequently imported to the inner membrane. These results demonstrate that TMEM126A mRNA is an MLR, with asymmetric localization to the mitochondrial surface similar to UQCRC1 mRNA, which is known to encode a mitochondrial protein of the IM. " RLID00023666 84233 TMEM126A http://www.ncbi.nlm.nih.gov/gene/?term=84233 OPA7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023667 84236 RHBDD1 http://www.ncbi.nlm.nih.gov/gene/?term=84236 RRP4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023668 84240 ZCCHC9 http://www.ncbi.nlm.nih.gov/gene/?term=84240 PPP1R41 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023669 84243 ZDHHC18 http://www.ncbi.nlm.nih.gov/gene/?term=84243 "DHHC-18, DHHC18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023670 84243 ZDHHC18 http://www.ncbi.nlm.nih.gov/gene/?term=84243 "DHHC-18, DHHC18 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023671 84245 MRI1 http://www.ncbi.nlm.nih.gov/gene/?term=84245 "MRDI, MTNA, Ypr118w " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023672 84245 MRI1 http://www.ncbi.nlm.nih.gov/gene/?term=84245 "MRDI, MTNA, Ypr118w " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023673 84245 MRI1 http://www.ncbi.nlm.nih.gov/gene/?term=84245 "MRDI, MTNA, Ypr118w " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023674 84246 MED10 http://www.ncbi.nlm.nih.gov/gene/?term=84246 "L6, NUT2, TRG20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023675 84246 MED10 http://www.ncbi.nlm.nih.gov/gene/?term=84246 "L6, NUT2, TRG20 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023676 84247 LDOC1L http://www.ncbi.nlm.nih.gov/gene/?term=84247 "Mar6, Mart6, dJ1033E15.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023677 84247 LDOC1L http://www.ncbi.nlm.nih.gov/gene/?term=84247 "Mar6, Mart6, dJ1033E15.2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023678 84247 LDOC1L http://www.ncbi.nlm.nih.gov/gene/?term=84247 "Mar6, Mart6, dJ1033E15.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023679 84248 FYTTD1 http://www.ncbi.nlm.nih.gov/gene/?term=84248 UIF mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023680 84250 SLF1 http://www.ncbi.nlm.nih.gov/gene/?term=84250 "ANKRD32, BRCTD1, BRCTx " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023681 84251 SGIP1 http://www.ncbi.nlm.nih.gov/gene/?term=84251 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023682 84254 CAMKK1 http://www.ncbi.nlm.nih.gov/gene/?term=84254 CAMKKA mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023683 84255 SLC37A3 http://www.ncbi.nlm.nih.gov/gene/?term=84255 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023684 84255 SLC37A3 http://www.ncbi.nlm.nih.gov/gene/?term=84255 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023685 84259 DCUN1D5 http://www.ncbi.nlm.nih.gov/gene/?term=84259 SCCRO5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023686 84259 DCUN1D5 http://www.ncbi.nlm.nih.gov/gene/?term=84259 SCCRO5 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023687 8425 LTBP4 http://www.ncbi.nlm.nih.gov/gene/?term=8425 "ARCL1C, LTBP-4, LTBP4L, LTBP4S " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023688 84260 TCHP http://www.ncbi.nlm.nih.gov/gene/?term=84260 TpMs mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023689 84261 FBXW9 http://www.ncbi.nlm.nih.gov/gene/?term=84261 Fbw9 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023690 84262 PSMG3 http://www.ncbi.nlm.nih.gov/gene/?term=84262 "C7orf48, PAC3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023691 84262 PSMG3 http://www.ncbi.nlm.nih.gov/gene/?term=84262 "C7orf48, PAC3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023692 84263 HSDL2 http://www.ncbi.nlm.nih.gov/gene/?term=84263 "C9orf99, SDR13C1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023693 84263 HSDL2 http://www.ncbi.nlm.nih.gov/gene/?term=84263 "C9orf99, SDR13C1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023694 84264 HAGHL http://www.ncbi.nlm.nih.gov/gene/?term=84264 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023695 84265 POLR3GL http://www.ncbi.nlm.nih.gov/gene/?term=84265 "RPC32HOM, flj32422 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023696 84266 ALKBH7 http://www.ncbi.nlm.nih.gov/gene/?term=84266 "ABH7, SPATA11, UNQ6002 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023697 84266 ALKBH7 http://www.ncbi.nlm.nih.gov/gene/?term=84266 "ABH7, SPATA11, UNQ6002 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023698 84268 RPAIN http://www.ncbi.nlm.nih.gov/gene/?term=84268 "HRIP, RIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023699 84268 RPAIN http://www.ncbi.nlm.nih.gov/gene/?term=84268 "HRIP, RIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023700 84269 CHCHD5 http://www.ncbi.nlm.nih.gov/gene/?term=84269 "C2orf9, MIC14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023701 84270 CARD19 http://www.ncbi.nlm.nih.gov/gene/?term=84270 "BinCARD, C9orf89 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023702 84271 POLDIP3 http://www.ncbi.nlm.nih.gov/gene/?term=84271 "PDIP46, SKAR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023703 84271 POLDIP3 http://www.ncbi.nlm.nih.gov/gene/?term=84271 "PDIP46, SKAR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023704 84272 YIPF4 http://www.ncbi.nlm.nih.gov/gene/?term=84272 "FinGER4, Nbla11189 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023705 84272 YIPF4 http://www.ncbi.nlm.nih.gov/gene/?term=84272 "FinGER4, Nbla11189 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023706 84274 COQ5 http://www.ncbi.nlm.nih.gov/gene/?term=84274 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023707 84275 SLC25A33 http://www.ncbi.nlm.nih.gov/gene/?term=84275 "BMSC-MCP, PNC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023708 84275 SLC25A33 http://www.ncbi.nlm.nih.gov/gene/?term=84275 "BMSC-MCP, PNC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023709 84277 DNAJC30 http://www.ncbi.nlm.nih.gov/gene/?term=84277 WBSCR18 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023710 84277 DNAJC30 http://www.ncbi.nlm.nih.gov/gene/?term=84277 WBSCR18 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023711 84279 PRADC1 http://www.ncbi.nlm.nih.gov/gene/?term=84279 "C2orf7, PAP21 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023712 8427 ZNF282 http://www.ncbi.nlm.nih.gov/gene/?term=8427 HUB1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023713 84280 BTBD10 http://www.ncbi.nlm.nih.gov/gene/?term=84280 "GMRP-1, GMRP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023714 84280 BTBD10 http://www.ncbi.nlm.nih.gov/gene/?term=84280 "GMRP-1, GMRP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023715 84282 RNF135 http://www.ncbi.nlm.nih.gov/gene/?term=84282 "L13, MMFD, REUL, Riplet " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023716 84284 NTPCR http://www.ncbi.nlm.nih.gov/gene/?term=84284 "C1orf57, HCR-NTPase " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023717 84285 EIF1AD http://www.ncbi.nlm.nih.gov/gene/?term=84285 haponin mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023718 84285 EIF1AD http://www.ncbi.nlm.nih.gov/gene/?term=84285 haponin mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023719 84285 EIF1AD http://www.ncbi.nlm.nih.gov/gene/?term=84285 haponin mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023720 84287 ZDHHC16 http://www.ncbi.nlm.nih.gov/gene/?term=84287 "APH2, DHHC-16 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023721 84288 EFCAB2 http://www.ncbi.nlm.nih.gov/gene/?term=84288 "CFAP200, DRC8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023722 84289 ING5 http://www.ncbi.nlm.nih.gov/gene/?term=84289 p28ING5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023723 84289 ING5 http://www.ncbi.nlm.nih.gov/gene/?term=84289 p28ING5 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023724 84289 ING5 http://www.ncbi.nlm.nih.gov/gene/?term=84289 p28ING5 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023725 8428 STK24 http://www.ncbi.nlm.nih.gov/gene/?term=8428 "HEL-S-95, MST3, MST3B, STE20, STK3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023726 8428 STK24 http://www.ncbi.nlm.nih.gov/gene/?term=8428 "HEL-S-95, MST3, MST3B, STE20, STK3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023727 8428 STK24 http://www.ncbi.nlm.nih.gov/gene/?term=8428 "HEL-S-95, MST3, MST3B, STE20, STK3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023728 84293 FAM213A http://www.ncbi.nlm.nih.gov/gene/?term=84293 "C10orf58, PAMM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023729 84295 PHF6 http://www.ncbi.nlm.nih.gov/gene/?term=84295 "BFLS, BORJ, CENP-31 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023730 84298 LLPH http://www.ncbi.nlm.nih.gov/gene/?term=84298 "C12orf31, hLLP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023731 84299 MIEN1 http://www.ncbi.nlm.nih.gov/gene/?term=84299 "C17orf37, C35, ORB3, RDX12, XTP4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023732 842 CASP9 http://www.ncbi.nlm.nih.gov/gene/?term=842 "APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023733 842 CASP9 http://www.ncbi.nlm.nih.gov/gene/?term=842 "APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023734 84300 UQCC2 http://www.ncbi.nlm.nih.gov/gene/?term=84300 "C6orf125, Cbp6, M19, MNF1, bA6B20.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023735 84301 DDI2 http://www.ncbi.nlm.nih.gov/gene/?term=84301 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023736 84302 TMEM246 http://www.ncbi.nlm.nih.gov/gene/?term=84302 C9orf125 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023737 84302 TMEM246 http://www.ncbi.nlm.nih.gov/gene/?term=84302 C9orf125 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023738 84303 CHCHD6 http://www.ncbi.nlm.nih.gov/gene/?term=84303 "CHCM1, Mic25, PPP1R23 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023739 84304 NUDT22 http://www.ncbi.nlm.nih.gov/gene/?term=84304 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023740 84305 PYM1 http://www.ncbi.nlm.nih.gov/gene/?term=84305 "PYM, WIBG " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023741 84305 PYM1 http://www.ncbi.nlm.nih.gov/gene/?term=84305 "PYM, WIBG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023742 84306 PDCD2L http://www.ncbi.nlm.nih.gov/gene/?term=84306 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023743 84307 ZNF397 http://www.ncbi.nlm.nih.gov/gene/?term=84307 "ZNF47, ZSCAN15 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023744 84307 ZNF397 http://www.ncbi.nlm.nih.gov/gene/?term=84307 "ZNF47, ZSCAN15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023745 84309 NUDT16L1 http://www.ncbi.nlm.nih.gov/gene/?term=84309 SDOS mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023746 84310 C7orf50 http://www.ncbi.nlm.nih.gov/gene/?term=84310 YCR016W mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023747 84310 C7orf50 http://www.ncbi.nlm.nih.gov/gene/?term=84310 YCR016W mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023748 84311 MRPL45 http://www.ncbi.nlm.nih.gov/gene/?term=84311 "L45mt, MRP-L45 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023749 84313 VPS25 http://www.ncbi.nlm.nih.gov/gene/?term=84313 "DERP9, EAP20, FAP20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023750 84313 VPS25 http://www.ncbi.nlm.nih.gov/gene/?term=84313 "DERP9, EAP20, FAP20 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023751 84313 VPS25 http://www.ncbi.nlm.nih.gov/gene/?term=84313 "DERP9, EAP20, FAP20 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023752 84314 TMEM107 http://www.ncbi.nlm.nih.gov/gene/?term=84314 "GRVS638, PRO1268 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023753 84314 TMEM107 http://www.ncbi.nlm.nih.gov/gene/?term=84314 "GRVS638, PRO1268 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023754 84314 TMEM107 http://www.ncbi.nlm.nih.gov/gene/?term=84314 "GRVS638, PRO1268 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023755 84314 TMEM107 http://www.ncbi.nlm.nih.gov/gene/?term=84314 "GRVS638, PRO1268 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023756 84315 MON1A http://www.ncbi.nlm.nih.gov/gene/?term=84315 SAND1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023757 84315 MON1A http://www.ncbi.nlm.nih.gov/gene/?term=84315 SAND1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023758 84316 NAA38 http://www.ncbi.nlm.nih.gov/gene/?term=84316 "LSMD1, PFAAP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023759 84317 CCDC115 http://www.ncbi.nlm.nih.gov/gene/?term=84317 "CDG2O, ccp1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023760 84317 CCDC115 http://www.ncbi.nlm.nih.gov/gene/?term=84317 ccp1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023761 84319 CMSS1 http://www.ncbi.nlm.nih.gov/gene/?term=84319 C3orf26 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023762 84319 CMSS1 http://www.ncbi.nlm.nih.gov/gene/?term=84319 C3orf26 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023763 84321 THOC3 http://www.ncbi.nlm.nih.gov/gene/?term=84321 "THO3, hTREX45 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023764 84324 SARNP http://www.ncbi.nlm.nih.gov/gene/?term=84324 "CIP29, HCC1, HSPC316, THO1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023765 84326 C16orf13 http://www.ncbi.nlm.nih.gov/gene/?term=84326 JFP2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023766 84326 C16orf13 http://www.ncbi.nlm.nih.gov/gene/?term=84326 JFP2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023767 84331 FAM195A http://www.ncbi.nlm.nih.gov/gene/?term=84331 "C16orf14, c349E10.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023768 84331 MCRIP2 http://www.ncbi.nlm.nih.gov/gene/?term=84331 "C16orf14, c349E10.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023769 84333 PCGF5 http://www.ncbi.nlm.nih.gov/gene/?term=84333 RNF159 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023770 84334 APOPT1 http://www.ncbi.nlm.nih.gov/gene/?term=84334 "APOP, APOP1, C14orf153 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023771 84335 AKT1S1 http://www.ncbi.nlm.nih.gov/gene/?term=84335 "Lobe, PRAS40 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023772 84335 AKT1S1 http://www.ncbi.nlm.nih.gov/gene/?term=84335 "Lobe, PRAS40 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023773 84336 TMEM101 http://www.ncbi.nlm.nih.gov/gene/?term=84336 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023774 84336 TMEM101 http://www.ncbi.nlm.nih.gov/gene/?term=84336 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023775 84337 ELOF1 http://www.ncbi.nlm.nih.gov/gene/?term=84337 ELF1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023776 84337 ELOF1 http://www.ncbi.nlm.nih.gov/gene/?term=84337 ELF1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023777 84340 GFM2 http://www.ncbi.nlm.nih.gov/gene/?term=84340 "EF-G2mt, EFG2, MRRF2, MST027, MSTP027, RRF2, RRF2mt, hEFG2, mEF-G 2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023778 84340 GFM2 http://www.ncbi.nlm.nih.gov/gene/?term=84340 "EF-G2mt, EFG2, MRRF2, MST027, MSTP027, RRF2, RRF2mt, hEFG2, mEF-G 2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023779 84343 HPS3 http://www.ncbi.nlm.nih.gov/gene/?term=84343 "BLOC2S1, SUTAL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023780 84364 ARFGAP2 http://www.ncbi.nlm.nih.gov/gene/?term=84364 "IRZ, NBLA10535, ZFP289, ZNF289 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023781 84365 NIFK http://www.ncbi.nlm.nih.gov/gene/?term=84365 "MKI67IP, Nopp34 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023782 84365 NIFK http://www.ncbi.nlm.nih.gov/gene/?term=84365 "MKI67IP, Nopp34 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023783 84365 NIFK http://www.ncbi.nlm.nih.gov/gene/?term=84365 "MKI67IP, Nopp34 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023784 8436 SDPR http://www.ncbi.nlm.nih.gov/gene/?term=8436 "CAVIN2, PS-p68, SDR, cavin-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023785 84376 HOOK3 http://www.ncbi.nlm.nih.gov/gene/?term=84376 HK3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023786 84376 HOOK3 http://www.ncbi.nlm.nih.gov/gene/?term=84376 HK3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023787 8438 RAD54L http://www.ncbi.nlm.nih.gov/gene/?term=8438 "HR54, RAD54A, hHR54, hRAD54 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023788 8439 NSMAF http://www.ncbi.nlm.nih.gov/gene/?term=8439 "FAN, GRAMD5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023789 8439 NSMAF http://www.ncbi.nlm.nih.gov/gene/?term=8439 "FAN, GRAMD5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023790 843 CASP10 http://www.ncbi.nlm.nih.gov/gene/?term=843 "ALPS2, FLICE2, MCH4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023791 843 CASP10 http://www.ncbi.nlm.nih.gov/gene/?term=843 "ALPS2, FLICE2, MCH4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023792 843 CASP10 http://www.ncbi.nlm.nih.gov/gene/?term=843 "ALPS2, FLICE2, MCH4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023793 8440 NCK2 http://www.ncbi.nlm.nih.gov/gene/?term=8440 "GRB4, NCKbeta " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023794 84418 CYSTM1 http://www.ncbi.nlm.nih.gov/gene/?term=84418 "C5orf32, ORF1-FL49 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023795 84418 CYSTM1 http://www.ncbi.nlm.nih.gov/gene/?term=84418 "C5orf32, ORF1-FL49 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023796 84436 ZNF528 http://www.ncbi.nlm.nih.gov/gene/?term=84436 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023797 84436 ZNF528 http://www.ncbi.nlm.nih.gov/gene/?term=84436 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023798 84436 ZNF528 http://www.ncbi.nlm.nih.gov/gene/?term=84436 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023799 84437 MSANTD4 http://www.ncbi.nlm.nih.gov/gene/?term=84437 KIAA1826 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023800 8443 GNPAT http://www.ncbi.nlm.nih.gov/gene/?term=8443 "DAP-AT, DAPAT, DHAPAT, RCDP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023801 84440 RAB11FIP4 http://www.ncbi.nlm.nih.gov/gene/?term=84440 RAB11-FIP4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023802 84440 RAB11FIP4 http://www.ncbi.nlm.nih.gov/gene/?term=84440 RAB11-FIP4 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023803 84440 RAB11FIP4 http://www.ncbi.nlm.nih.gov/gene/?term=84440 RAB11-FIP4 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023804 84444 DOT1L http://www.ncbi.nlm.nih.gov/gene/?term=84444 "DOT1, KMT4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023805 84445 LZTS2 http://www.ncbi.nlm.nih.gov/gene/?term=84445 LAPSER1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023806 84445 LZTS2 http://www.ncbi.nlm.nih.gov/gene/?term=84445 LAPSER1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023807 84447 SYVN1 http://www.ncbi.nlm.nih.gov/gene/?term=84447 "DER3, HRD1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023808 8444 DYRK3 http://www.ncbi.nlm.nih.gov/gene/?term=8444 "DYRK5, RED, REDK, hYAK3-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023809 84450 ZNF512 http://www.ncbi.nlm.nih.gov/gene/?term=84450 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023810 84455 EFCAB7 http://www.ncbi.nlm.nih.gov/gene/?term=84455 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023811 84458 LCOR http://www.ncbi.nlm.nih.gov/gene/?term=84458 MLR2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023812 8445 DYRK2 http://www.ncbi.nlm.nih.gov/gene/?term=8445 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023813 8445 DYRK2 http://www.ncbi.nlm.nih.gov/gene/?term=8445 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023814 84460 ZMAT1 http://www.ncbi.nlm.nih.gov/gene/?term=84460 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023815 84460 ZMAT1 http://www.ncbi.nlm.nih.gov/gene/?term=84460 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023816 84461 NEURL4 http://www.ncbi.nlm.nih.gov/gene/?term=84461 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023817 84464 SLX4 http://www.ncbi.nlm.nih.gov/gene/?term=84464 "BTBD12, FANCP, MUS312 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023818 84464 SLX4 http://www.ncbi.nlm.nih.gov/gene/?term=84464 "BTBD12, FANCP, MUS312 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023819 8446 DUSP11 http://www.ncbi.nlm.nih.gov/gene/?term=8446 PIR1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023820 8446 DUSP11 http://www.ncbi.nlm.nih.gov/gene/?term=8446 PIR1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023821 84498 FAM120B http://www.ncbi.nlm.nih.gov/gene/?term=84498 "CCPG, KIAA1838, PGCC1, dJ894D12.1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023822 8449 DHX16 http://www.ncbi.nlm.nih.gov/gene/?term=8449 "DBP2, DDX16, PRO2014, PRP8, PRPF2, Prp2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023823 84501 SPIRE2 http://www.ncbi.nlm.nih.gov/gene/?term=84501 Spir-2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023824 84502 JPH4 http://www.ncbi.nlm.nih.gov/gene/?term=84502 "JP4, JPHL1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023825 84503 ZNF527 http://www.ncbi.nlm.nih.gov/gene/?term=84503 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023826 84503 ZNF527 http://www.ncbi.nlm.nih.gov/gene/?term=84503 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023827 84505 Setdb1 http://www.ncbi.nlm.nih.gov/gene/?term=84505 "AU022152, ESET, KMT1E, mKIAA0067 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00023828 84506 Hamp http://www.ncbi.nlm.nih.gov/gene/?term=84506 "Hamp1, Hepc, Hepc1 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00023829 84513 PLPP5 http://www.ncbi.nlm.nih.gov/gene/?term=84513 "DPPL1, HTPAP, PPAPDC1B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023830 84514 GHDC http://www.ncbi.nlm.nih.gov/gene/?term=84514 "D11LGP1, LGP1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023831 84514 GHDC http://www.ncbi.nlm.nih.gov/gene/?term=84514 "D11LGP1, LGP1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023832 84515 MCM8 http://www.ncbi.nlm.nih.gov/gene/?term=84515 "C20orf154, POF10, dJ967N21.5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023833 84515 MCM8 http://www.ncbi.nlm.nih.gov/gene/?term=84515 "C20orf154, POF10, dJ967N21.5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023834 84516 DCTN5 http://www.ncbi.nlm.nih.gov/gene/?term=84516 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023835 84516 DCTN5 http://www.ncbi.nlm.nih.gov/gene/?term=84516 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023836 84516 DCTN5 http://www.ncbi.nlm.nih.gov/gene/?term=84516 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023837 8451 CUL4A http://www.ncbi.nlm.nih.gov/gene/?term=8451 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023838 84520 C14orf142 http://www.ncbi.nlm.nih.gov/gene/?term=84520 PNAS-127 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023839 84527 ZNF559 http://www.ncbi.nlm.nih.gov/gene/?term=84527 NBLA00121 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023840 84529 C15orf41 http://www.ncbi.nlm.nih.gov/gene/?term=84529 HH114 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023841 8452 CUL3 http://www.ncbi.nlm.nih.gov/gene/?term=8452 "CUL-3, PHA2E " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023842 8452 CUL3 http://www.ncbi.nlm.nih.gov/gene/?term=8452 "CUL-3, PHA2E " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023843 8452 CUL3 http://www.ncbi.nlm.nih.gov/gene/?term=8452 "CUL-3, PHA2E " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023844 8452 CUL3 http://www.ncbi.nlm.nih.gov/gene/?term=8452 "CUL-3, PHA2E " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023845 84530 SRRM4 http://www.ncbi.nlm.nih.gov/gene/?term=84530 "KIAA1853, MU-MB-2.76, nSR100 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023846 8453 CUL2 http://www.ncbi.nlm.nih.gov/gene/?term=8453 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023847 84545 MRPL43 http://www.ncbi.nlm.nih.gov/gene/?term=84545 "L43mt, MRP-L43, bMRP36a " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023848 84545 MRPL43 http://www.ncbi.nlm.nih.gov/gene/?term=84545 "L43mt, MRP-L43, bMRP36a " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023849 84548 TMEM185A http://www.ncbi.nlm.nih.gov/gene/?term=84548 "CXorf13, FAM11A, FRAXF, ee3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023850 84549 MAK16 http://www.ncbi.nlm.nih.gov/gene/?term=84549 "MAK16L, RBM13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023851 8454 CUL1 http://www.ncbi.nlm.nih.gov/gene/?term=8454 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023852 8454 CUL1 http://www.ncbi.nlm.nih.gov/gene/?term=8454 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023853 84552 PARD6G http://www.ncbi.nlm.nih.gov/gene/?term=84552 "PAR-6G, PAR6gamma " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023854 84552 PARD6G http://www.ncbi.nlm.nih.gov/gene/?term=84552 "PAR-6G, PAR6gamma " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023855 84557 MAP1LC3A http://www.ncbi.nlm.nih.gov/gene/?term=84557 "ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023856 84557 MAP1LC3A http://www.ncbi.nlm.nih.gov/gene/?term=84557 "ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023857 8455 ATRN http://www.ncbi.nlm.nih.gov/gene/?term=8455 "DPPT-L, MGCA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023858 8455 ATRN http://www.ncbi.nlm.nih.gov/gene/?term=8455 "DPPT-L, MGCA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023859 84561 SLC12A8 http://www.ncbi.nlm.nih.gov/gene/?term=84561 CCC9 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023860 84572 GNPTG http://www.ncbi.nlm.nih.gov/gene/?term=84572 "C16orf27, GNPTAG, LP2537, RJD9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023861 84572 GNPTG http://www.ncbi.nlm.nih.gov/gene/?term=84572 "C16orf27, GNPTAG, LP2537, RJD9 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023862 8458 TTF2 http://www.ncbi.nlm.nih.gov/gene/?term=8458 "HuF2, ZGRF6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023863 8459 TPST2 http://www.ncbi.nlm.nih.gov/gene/?term=8459 TANGO13B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023864 8459 TPST2 http://www.ncbi.nlm.nih.gov/gene/?term=8459 TANGO13B mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023865 84604 Hamp http://www.ncbi.nlm.nih.gov/gene/?term=84604 Hepc mRNA Rattus norvegicus 26180210 Axon Spinal cord In situ hybridization "By quantitative fluorescent in situ hybridization combined with immunofluorescence to unambiguously distinguish intra-axonal mRNAs, we show that regenerating spinal cord axons contain β-actin, GAP-43, Neuritin, Reg3a, Hamp, and Importin β1 mRNAs. " RLID00023866 84612 PARD6B http://www.ncbi.nlm.nih.gov/gene/?term=84612 PAR6B mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023867 84612 PARD6B http://www.ncbi.nlm.nih.gov/gene/?term=84612 PAR6B mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023868 84617 TUBB6 http://www.ncbi.nlm.nih.gov/gene/?term=84617 "HsT1601, TUBB-5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023869 84624 FNDC1 http://www.ncbi.nlm.nih.gov/gene/?term=84624 "AGS8, FNDC2, MEL4B3, bA243O10.1, dJ322A24.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023870 84626 KRBA1 http://www.ncbi.nlm.nih.gov/gene/?term=84626 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023871 84629 TNRC18 http://www.ncbi.nlm.nih.gov/gene/?term=84629 "CAGL79, TNRC18A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023872 84631 SLITRK2 http://www.ncbi.nlm.nih.gov/gene/?term=84631 "CXorf2, SLITL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023873 84632 AFAP1L2 http://www.ncbi.nlm.nih.gov/gene/?term=84632 "CTB-1144G6.4, KIAA1914, XB130 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023874 8463 TEAD2 http://www.ncbi.nlm.nih.gov/gene/?term=8463 "ETF, TEAD-2, TEF-4, TEF4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023875 84640 USP38 http://www.ncbi.nlm.nih.gov/gene/?term=84640 HP43.8KD mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023876 84640 USP38 http://www.ncbi.nlm.nih.gov/gene/?term=84640 HP43.8KD mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023877 84641 MFSD14B http://www.ncbi.nlm.nih.gov/gene/?term=84641 HIATL1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023878 84641 MFSD14B http://www.ncbi.nlm.nih.gov/gene/?term=84641 HIATL1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023879 84649 DGAT2 http://www.ncbi.nlm.nih.gov/gene/?term=84649 "ARAT, GS1999FULL, HMFN1045 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023880 84649 DGAT2 http://www.ncbi.nlm.nih.gov/gene/?term=84649 "ARAT, GS1999FULL, HMFN1045 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023881 84650 EBPL http://www.ncbi.nlm.nih.gov/gene/?term=84650 EBRP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023882 84650 EBPL http://www.ncbi.nlm.nih.gov/gene/?term=84650 EBRP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023883 84661 DPY30 http://www.ncbi.nlm.nih.gov/gene/?term=84661 "Cps25, HDPY-30, Saf19 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023884 84661 DPY30 http://www.ncbi.nlm.nih.gov/gene/?term=84661 "Cps25, HDPY-30, Saf19 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023885 84662 GLIS2 http://www.ncbi.nlm.nih.gov/gene/?term=84662 "NKL, NPHP7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023886 84665 MYPN http://www.ncbi.nlm.nih.gov/gene/?term=84665 "CMD1DD, CMH22, MYOP, RCM4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023887 84666 RETNLB http://www.ncbi.nlm.nih.gov/gene/?term=84666 "FIZZ1, FIZZ2, HXCP2, RELM-beta, RELMb, RELMbeta, XCP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023888 84668 FAM126A http://www.ncbi.nlm.nih.gov/gene/?term=84668 "DRCTNNB1A, HCC, HLD5, HYCC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023889 84668 FAM126A http://www.ncbi.nlm.nih.gov/gene/?term=84668 "DRCTNNB1A, HCC, HLD5, HYCC1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023890 84668 FAM126A http://www.ncbi.nlm.nih.gov/gene/?term=84668 "DRCTNNB1A, HCC, HLD5, HYCC1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023891 84669 USP32 http://www.ncbi.nlm.nih.gov/gene/?term=84669 "NY-REN-60, USP10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023892 84678 KDM2B http://www.ncbi.nlm.nih.gov/gene/?term=84678 "CXXC2, FBXL10, Fbl10, JHDM1B, PCCX2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023893 8467 SMARCA5 http://www.ncbi.nlm.nih.gov/gene/?term=8467 "ISWI, SNF2H, WCRF135, hISWI, hSNF2H " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023894 8467 SMARCA5 http://www.ncbi.nlm.nih.gov/gene/?term=8467 "ISWI, SNF2H, WCRF135, hISWI, hSNF2H " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023895 84681 HINT2 http://www.ncbi.nlm.nih.gov/gene/?term=84681 HIT-17 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023896 84681 HINT2 http://www.ncbi.nlm.nih.gov/gene/?term=84681 HIT-17 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023897 84682 Cox4i2 http://www.ncbi.nlm.nih.gov/gene/?term=84682 "Cox4b, CoxIV-2 " mRNA Mus musculus 24152552 Axon Motorneuron RT-PCR Two mRNAs (Anxa2 and Cox4i2) colocalize with the SMN protein in axons from differentiated NSC-34 cells and that their axonal localization is dramatically reduced in SMN-deficient cells RLID00023898 84695 LOXL3 http://www.ncbi.nlm.nih.gov/gene/?term=84695 LOXL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023899 84705 GTPBP3 http://www.ncbi.nlm.nih.gov/gene/?term=84705 "COXPD23, GTPBG3, MSS1, MTGP1, THDF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023900 84705 GTPBP3 http://www.ncbi.nlm.nih.gov/gene/?term=84705 "COXPD23, GTPBG3, MSS1, MTGP1, THDF1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023901 84705 GTPBP3 http://www.ncbi.nlm.nih.gov/gene/?term=84705 "COXPD23, GTPBG3, MSS1, MTGP1, THDF1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023902 84706 GPT2 http://www.ncbi.nlm.nih.gov/gene/?term=84706 "ALT2, GPT 2, MRT49 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023903 84720 PIGO http://www.ncbi.nlm.nih.gov/gene/?term=84720 HPMRS2 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023904 84720 PIGO http://www.ncbi.nlm.nih.gov/gene/?term=84720 HPMRS2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023905 84722 PSRC1 http://www.ncbi.nlm.nih.gov/gene/?term=84722 "DDA3, FP3214 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023906 84725 PLEKHA8 http://www.ncbi.nlm.nih.gov/gene/?term=84725 FAPP2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023907 84725 PLEKHA8 http://www.ncbi.nlm.nih.gov/gene/?term=84725 FAPP2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023908 84726 PRRC2B http://www.ncbi.nlm.nih.gov/gene/?term=84726 "BAT2L, BAT2L1, KIAA0515, LQFBS-1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023909 8473 OGT http://www.ncbi.nlm.nih.gov/gene/?term=8473 "HINCUT-1, HRNT1, O-GLCNAC " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023910 8473 OGT http://www.ncbi.nlm.nih.gov/gene/?term=8473 "HINCUT-1, HRNT1, O-GLCNAC " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023911 8473 OGT http://www.ncbi.nlm.nih.gov/gene/?term=8473 "HINCUT-1, HRNT1, O-GLCNAC " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023912 84740 AFAP1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=84740 "AFAP1-AS, AFAP1AS " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023913 84747 UNC119B http://www.ncbi.nlm.nih.gov/gene/?term=84747 POC7B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023914 84749 USP30 http://www.ncbi.nlm.nih.gov/gene/?term=84749 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023915 84752 B3GNT9 http://www.ncbi.nlm.nih.gov/gene/?term=84752 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023916 84769 MPV17L2 http://www.ncbi.nlm.nih.gov/gene/?term=84769 FKSG24 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023917 8476 CDC42BPA http://www.ncbi.nlm.nih.gov/gene/?term=8476 "MRCK, MRCKA, PK428 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023918 8476 CDC42BPA http://www.ncbi.nlm.nih.gov/gene/?term=8476 "MRCK, MRCKA, PK428 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023919 8476 CDC42BPA http://www.ncbi.nlm.nih.gov/gene/?term=8476 "MRCK, MRCKA, PK428 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023920 84790 TUBA1C http://www.ncbi.nlm.nih.gov/gene/?term=84790 "TUBA6, bcm948 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023921 84790 TUBA1C http://www.ncbi.nlm.nih.gov/gene/?term=84790 "TUBA6, bcm948 " mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00023922 84791 LINC00467 http://www.ncbi.nlm.nih.gov/gene/?term=84791 C1orf97 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023923 84792 FAM220A http://www.ncbi.nlm.nih.gov/gene/?term=84792 "ACPIN1, C7orf70, SIPAR " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023924 84798 C19orf48 http://www.ncbi.nlm.nih.gov/gene/?term=84798 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023925 8479 HIRIP3 http://www.ncbi.nlm.nih.gov/gene/?term=8479 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023926 847 CAT http://www.ncbi.nlm.nih.gov/gene/?term=847 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023927 847 CAT http://www.ncbi.nlm.nih.gov/gene/?term=847 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023928 84804 MFSD9 http://www.ncbi.nlm.nih.gov/gene/?term=84804 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023929 84809 CROCCP2 http://www.ncbi.nlm.nih.gov/gene/?term=84809 CROCCL1 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023930 8480 RAE1 http://www.ncbi.nlm.nih.gov/gene/?term=8480 "MIG14, MRNP41, Mnrp41, dJ481F12.3, dJ800J21.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023931 8480 RAE1 http://www.ncbi.nlm.nih.gov/gene/?term=8480 "MIG14, MRNP41, Mnrp41, dJ481F12.3, dJ800J21.1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023932 8480 RAE1 http://www.ncbi.nlm.nih.gov/gene/?term=8480 "MIG14, MRNP41, Mnrp41, dJ481F12.3, dJ800J21.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023933 84811 BUD13 http://www.ncbi.nlm.nih.gov/gene/?term=84811 "Cwc26, fSAP71 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023934 84811 BUD13 http://www.ncbi.nlm.nih.gov/gene/?term=84811 "Cwc26, fSAP71 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023935 84816 RTN4IP1 http://www.ncbi.nlm.nih.gov/gene/?term=84816 "NIMP, OPA10 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023936 84816 RTN4IP1 http://www.ncbi.nlm.nih.gov/gene/?term=84816 "NIMP, OPA10 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023937 84817 TXNDC17 http://www.ncbi.nlm.nih.gov/gene/?term=84817 "TRP14, TXNL5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023938 84817 TXNDC17 http://www.ncbi.nlm.nih.gov/gene/?term=84817 "TRP14, TXNL5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023939 84818 IL17RC http://www.ncbi.nlm.nih.gov/gene/?term=84818 "CANDF9, IL17-RL, IL17RL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023940 8481 OFD1 http://www.ncbi.nlm.nih.gov/gene/?term=8481 "71-7A, CXorf5, JBTS10, RP23, SGBS2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023941 8481 OFD1 http://www.ncbi.nlm.nih.gov/gene/?term=8481 "71-7A, CXorf5, JBTS10, RP23, SGBS2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023942 84823 LMNB2 http://www.ncbi.nlm.nih.gov/gene/?term=84823 "EPM9, LAMB2, LMN2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023943 84823 LMNB2 http://www.ncbi.nlm.nih.gov/gene/?term=84823 "EPM9, LAMB2, LMN2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023944 84824 FCRLA http://www.ncbi.nlm.nih.gov/gene/?term=84824 "FCRL, FCRL1, FCRLM1, FCRLX, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRX, FREB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023945 84826 SFT2D3 http://www.ncbi.nlm.nih.gov/gene/?term=84826 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023946 84826 SFT2D3 http://www.ncbi.nlm.nih.gov/gene/?term=84826 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023947 8482 SEMA7A http://www.ncbi.nlm.nih.gov/gene/?term=8482 "CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023948 84830 ADTRP http://www.ncbi.nlm.nih.gov/gene/?term=84830 "AIG1L, C6orf105, dJ413H6.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023949 84833 USMG5 http://www.ncbi.nlm.nih.gov/gene/?term=84833 "DAPIT, HCVFTP2, bA792D24.4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023950 84838 ZNF496 http://www.ncbi.nlm.nih.gov/gene/?term=84838 "NIZP1, ZFP496, ZKSCAN17, ZSCAN49 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023951 84844 PHF5A http://www.ncbi.nlm.nih.gov/gene/?term=84844 "INI, Rds3, SAP14b, SF3B7, SF3b14b, bK223H9.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023952 84844 PHF5A http://www.ncbi.nlm.nih.gov/gene/?term=84844 "INI, Rds3, SAP14b, SF3B7, SF3b14b, bK223H9.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023953 84859 LRCH3 http://www.ncbi.nlm.nih.gov/gene/?term=84859 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023954 84864 MINA http://www.ncbi.nlm.nih.gov/gene/?term=84864 "MDIG53, NO52, ROX, MINA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023955 84864 MINA http://www.ncbi.nlm.nih.gov/gene/?term=84864 "MDIG53, NO52, ROX, MINA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023956 84864 MINA http://www.ncbi.nlm.nih.gov/gene/?term=84864 "MDIG, MINA53, NO52, ROX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023957 84866 TMEM25 http://www.ncbi.nlm.nih.gov/gene/?term=84866 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023958 84868 HAVCR2 http://www.ncbi.nlm.nih.gov/gene/?term=84868 "CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023959 84868 HAVCR2 http://www.ncbi.nlm.nih.gov/gene/?term=84868 "CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023960 84869 CBR4 http://www.ncbi.nlm.nih.gov/gene/?term=84869 SDR45C1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023961 84869 CBR4 http://www.ncbi.nlm.nih.gov/gene/?term=84869 SDR45C1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023962 84869 CBR4 http://www.ncbi.nlm.nih.gov/gene/?term=84869 SDR45C1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023963 84872 ZC3H10 http://www.ncbi.nlm.nih.gov/gene/?term=84872 ZC3HDC10 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023964 84876 ORAI1 http://www.ncbi.nlm.nih.gov/gene/?term=84876 "CRACM1, IMD9, ORAT1, TAM2, TMEM142A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023965 84879 MFSD2A http://www.ncbi.nlm.nih.gov/gene/?term=84879 "MCPH15, MFSD2, NLS1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023966 8487 GEMIN2 http://www.ncbi.nlm.nih.gov/gene/?term=8487 "SIP1, SIP1-delta " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023967 84881 RPUSD4 http://www.ncbi.nlm.nih.gov/gene/?term=84881 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023968 84881 RPUSD4 http://www.ncbi.nlm.nih.gov/gene/?term=84881 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023969 84883 AIFM2 http://www.ncbi.nlm.nih.gov/gene/?term=84883 "AMID, PRG3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023970 84883 AIFM2 http://www.ncbi.nlm.nih.gov/gene/?term=84883 "AMID, PRG3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023971 84883 AIFM2 http://www.ncbi.nlm.nih.gov/gene/?term=84883 "AMID, PRG3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023972 84883 AIFM2 http://www.ncbi.nlm.nih.gov/gene/?term=84883 "AMID, PRG3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023973 84885 ZDHHC12 http://www.ncbi.nlm.nih.gov/gene/?term=84885 "DHHC-12, ZNF400 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023974 84886 C1orf198 http://www.ncbi.nlm.nih.gov/gene/?term=84886 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023975 84886 C1orf198 http://www.ncbi.nlm.nih.gov/gene/?term=84886 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023976 84888 SPPL2A http://www.ncbi.nlm.nih.gov/gene/?term=84888 "IMP3, PSL2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023977 84888 SPPL2A http://www.ncbi.nlm.nih.gov/gene/?term=84888 "IMP3, PSL2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023978 84893 FBXO18 http://www.ncbi.nlm.nih.gov/gene/?term=84893 "FBH1, Fbx18, hFBH1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023979 84893 FBXO18 http://www.ncbi.nlm.nih.gov/gene/?term=84893 "FBH1, Fbx18, hFBH1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023980 84895 FAM73B http://www.ncbi.nlm.nih.gov/gene/?term=84895 C9orf54 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023981 84896 ATAD1 http://www.ncbi.nlm.nih.gov/gene/?term=84896 "AFDC1, FNP001, THORASE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023982 84896 ATAD1 http://www.ncbi.nlm.nih.gov/gene/?term=84896 "AFDC1, FNP001, THORASE " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023983 84897 TBRG1 http://www.ncbi.nlm.nih.gov/gene/?term=84897 "NIAM, TB-5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023984 84897 TBRG1 http://www.ncbi.nlm.nih.gov/gene/?term=84897 "NIAM, TB-5 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023985 84897 TBRG1 http://www.ncbi.nlm.nih.gov/gene/?term=84897 "NIAM, TB-5 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023986 84897 TBRG1 http://www.ncbi.nlm.nih.gov/gene/?term=84897 "NIAM, TB-5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023987 84900 RNFT2 http://www.ncbi.nlm.nih.gov/gene/?term=84900 TMEM118 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023988 84900 RNFT2 http://www.ncbi.nlm.nih.gov/gene/?term=84900 TMEM118 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023989 84901 NFATC2IP http://www.ncbi.nlm.nih.gov/gene/?term=84901 "ESC2, NIP45, RAD60 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023990 84904 ARHGEF39 http://www.ncbi.nlm.nih.gov/gene/?term=84904 C9orf100 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023991 84908 FAM136A http://www.ncbi.nlm.nih.gov/gene/?term=84908 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023992 84908 FAM136A http://www.ncbi.nlm.nih.gov/gene/?term=84908 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00023993 84908 FAM136A http://www.ncbi.nlm.nih.gov/gene/?term=84908 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023994 84909 C9orf3 http://www.ncbi.nlm.nih.gov/gene/?term=84909 "AOPEP, AP-O, APO, C90RF3, ONPEP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023995 8490 RGS5 http://www.ncbi.nlm.nih.gov/gene/?term=8490 "MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023996 84910 TMEM87B http://www.ncbi.nlm.nih.gov/gene/?term=84910 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00023997 84914 ZNF587 http://www.ncbi.nlm.nih.gov/gene/?term=84914 ZF6 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00023998 84914 ZNF587 http://www.ncbi.nlm.nih.gov/gene/?term=84914 ZF6 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00023999 84914 ZNF587 http://www.ncbi.nlm.nih.gov/gene/?term=84914 ZF6 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024000 84916 UTP4 http://www.ncbi.nlm.nih.gov/gene/?term=84916 "CIRH1A, CIRHIN, NAIC, TEX292 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024001 84916 UTP4 http://www.ncbi.nlm.nih.gov/gene/?term=84916 "CIRH1A, CIRHIN, NAIC, TEX292 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024002 84918 LRP11 http://www.ncbi.nlm.nih.gov/gene/?term=84918 "MANSC3, bA350J20.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024003 84919 PPP1R15B http://www.ncbi.nlm.nih.gov/gene/?term=84919 "CREP, MSSGM2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024004 84919 PPP1R15B http://www.ncbi.nlm.nih.gov/gene/?term=84919 "CREP, MSSGM2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024005 84919 PPP1R15B http://www.ncbi.nlm.nih.gov/gene/?term=84919 "CREP, MSSGM2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024006 84919 PPP1R15B http://www.ncbi.nlm.nih.gov/gene/?term=84919 "CREP, MSSGM2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024007 8491 MAP4K3 http://www.ncbi.nlm.nih.gov/gene/?term=8491 "GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024008 84920 ALG10 http://www.ncbi.nlm.nih.gov/gene/?term=84920 "ALG10A, DIE2, KCR1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024009 84920 ALG10 http://www.ncbi.nlm.nih.gov/gene/?term=84920 "ALG10A, DIE2, KCR1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024010 84923 FAM104A http://www.ncbi.nlm.nih.gov/gene/?term=84923 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024011 84923 FAM104A http://www.ncbi.nlm.nih.gov/gene/?term=84923 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024012 84925 DIRC2 http://www.ncbi.nlm.nih.gov/gene/?term=84925 RCC4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024013 84926 SPRYD3 http://www.ncbi.nlm.nih.gov/gene/?term=84926 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024014 84929 FIBCD1 http://www.ncbi.nlm.nih.gov/gene/?term=84929 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024015 8492 PRSS12 http://www.ncbi.nlm.nih.gov/gene/?term=8492 "BSSP-3, BSSP3, MRT1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024016 84930 MASTL http://www.ncbi.nlm.nih.gov/gene/?term=84930 "GREATWALL, GW, GWL, MAST-L, THC2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024017 84933 C8orf76 http://www.ncbi.nlm.nih.gov/gene/?term=84933 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024018 84934 RITA1 http://www.ncbi.nlm.nih.gov/gene/?term=84934 "C12orf52, RITA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024019 84934 RITA1 http://www.ncbi.nlm.nih.gov/gene/?term=84934 "C12orf52, RITA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024020 84936 ZFYVE19 http://www.ncbi.nlm.nih.gov/gene/?term=84936 "ANCHR, MPFYVE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024021 84936 ZFYVE19 http://www.ncbi.nlm.nih.gov/gene/?term=84936 "ANCHR, MPFYVE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024022 84937 ZNRF1 http://www.ncbi.nlm.nih.gov/gene/?term=84937 NIN283 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024023 84937 ZNRF1 http://www.ncbi.nlm.nih.gov/gene/?term=84937 NIN283 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024024 84938 ATG4C http://www.ncbi.nlm.nih.gov/gene/?term=84938 "APG4-C, APG4C, AUTL1, AUTL3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024025 84939 MUM1 http://www.ncbi.nlm.nih.gov/gene/?term=84939 "EXPAND1, HSPC211, MUM-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024026 8493 PPM1D http://www.ncbi.nlm.nih.gov/gene/?term=8493 "PP2C-DELTA, WIP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024027 84942 WDR73 http://www.ncbi.nlm.nih.gov/gene/?term=84942 "GAMOS, HSPC264 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024028 84945 ABHD13 http://www.ncbi.nlm.nih.gov/gene/?term=84945 "BEM46L1, C13orf6, bA153I24.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024029 84946 LTV1 http://www.ncbi.nlm.nih.gov/gene/?term=84946 "C6orf93, dJ468K18.4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024030 84946 LTV1 http://www.ncbi.nlm.nih.gov/gene/?term=84946 "C6orf93, dJ468K18.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024031 84947 SERAC1 http://www.ncbi.nlm.nih.gov/gene/?term=84947 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024032 84948 TIGD5 http://www.ncbi.nlm.nih.gov/gene/?term=84948 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024033 84948 TIGD5 http://www.ncbi.nlm.nih.gov/gene/?term=84948 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024034 84950 PRPF38A http://www.ncbi.nlm.nih.gov/gene/?term=84950 Prp38 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024035 84950 PRPF38A http://www.ncbi.nlm.nih.gov/gene/?term=84950 Prp38 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024036 84954 MPND http://www.ncbi.nlm.nih.gov/gene/?term=84954 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024037 84955 NUDCD1 http://www.ncbi.nlm.nih.gov/gene/?term=84955 "CML66, OVA66 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024038 84958 SYTL1 http://www.ncbi.nlm.nih.gov/gene/?term=84958 "JFC1, SLP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024039 84959 UBASH3B http://www.ncbi.nlm.nih.gov/gene/?term=84959 "STS-1, STS1, TULA-2, TULA2, p70 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024040 84959 UBASH3B http://www.ncbi.nlm.nih.gov/gene/?term=84959 "STS-1, STS1, TULA-2, TULA2, p70 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024041 84959 UBASH3B http://www.ncbi.nlm.nih.gov/gene/?term=84959 "STS-1, STS1, TULA-2, TULA2, p70 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024042 8495 PPFIBP2 http://www.ncbi.nlm.nih.gov/gene/?term=8495 Cclp1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024043 84962 AJUBA http://www.ncbi.nlm.nih.gov/gene/?term=84962 JUB mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024044 84967 LSM10 http://www.ncbi.nlm.nih.gov/gene/?term=84967 "MST074, MSTP074 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024045 8496 PPFIBP1 http://www.ncbi.nlm.nih.gov/gene/?term=8496 "L2, SGT2, hSGT2, hSgt2p " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024046 8496 PPFIBP1 http://www.ncbi.nlm.nih.gov/gene/?term=8496 "L2, SGT2, hSGT2, hSgt2p " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024047 84971 ATG4D http://www.ncbi.nlm.nih.gov/gene/?term=84971 "APG4-D, APG4D, AUTL4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024048 84973 SNHG7 http://www.ncbi.nlm.nih.gov/gene/?term=84973 NCRNA00061 lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024049 84975 MFSD5 http://www.ncbi.nlm.nih.gov/gene/?term=84975 hsMOT2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024050 84976 DISP1 http://www.ncbi.nlm.nih.gov/gene/?term=84976 DISPA mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024051 84981 MIR22HG http://www.ncbi.nlm.nih.gov/gene/?term=84981 C17orf91 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024052 84984 CEP19 http://www.ncbi.nlm.nih.gov/gene/?term=84984 "C3orf34, MOSPGF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024053 84985 FAM83A http://www.ncbi.nlm.nih.gov/gene/?term=84985 BJ-TSA-9 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024054 84986 ARHGAP19 http://www.ncbi.nlm.nih.gov/gene/?term=84986 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024055 84987 COX14 http://www.ncbi.nlm.nih.gov/gene/?term=84987 C12orf62 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024056 84987 COX14 http://www.ncbi.nlm.nih.gov/gene/?term=84987 C12orf62 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024057 84988 PPP1R16A http://www.ncbi.nlm.nih.gov/gene/?term=84988 MYPT3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024058 8498 RANBP3 http://www.ncbi.nlm.nih.gov/gene/?term=8498 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024059 84991 RBM17 http://www.ncbi.nlm.nih.gov/gene/?term=84991 SPF45 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024060 84991 RBM17 http://www.ncbi.nlm.nih.gov/gene/?term=84991 SPF45 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024061 84992 PIGY http://www.ncbi.nlm.nih.gov/gene/?term=84992 "HPMRS6, PIG-Y " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024062 84996 URB1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=84996 "C21orf119, PRED84 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024063 8499 PPFIA2 http://www.ncbi.nlm.nih.gov/gene/?term=8499 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024064 8499 PPFIA2 http://www.ncbi.nlm.nih.gov/gene/?term=8499 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024065 8499 PPFIA2 http://www.ncbi.nlm.nih.gov/gene/?term=8499 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024066 85002 FAM86B1 http://www.ncbi.nlm.nih.gov/gene/?term=85002 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024067 85007 PHYKPL http://www.ncbi.nlm.nih.gov/gene/?term=85007 "AGXT2L2, PHLU " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024068 8500 PPFIA1 http://www.ncbi.nlm.nih.gov/gene/?term=8500 "LIP.1, LIP1, LIPRIN " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024069 8500 PPFIA1 http://www.ncbi.nlm.nih.gov/gene/?term=8500 "LIP.1, LIP1, LIPRIN " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024070 8500 PPFIA1 http://www.ncbi.nlm.nih.gov/gene/?term=8500 "LIP.1, LIP1, LIPRIN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024071 8500 PPFIA1 http://www.ncbi.nlm.nih.gov/gene/?term=8500 "LIP.1, LIP1, LIPRIN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024072 8500 PPFIA1 http://www.ncbi.nlm.nih.gov/gene/?term=8500 "LIP.1, LIP1, LIPRIN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024073 85013 TMEM128 http://www.ncbi.nlm.nih.gov/gene/?term=85013 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024074 85014 TMEM141 http://www.ncbi.nlm.nih.gov/gene/?term=85014 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024075 85019 TMEM241 http://www.ncbi.nlm.nih.gov/gene/?term=85019 "C18orf45, hVVT " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024076 8501 SLC43A1 http://www.ncbi.nlm.nih.gov/gene/?term=8501 "LAT3, PB39, POV1, R00504 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024077 85021 REPS1 http://www.ncbi.nlm.nih.gov/gene/?term=85021 RALBP1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024078 85026 ARRDC1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=85026 C9orf37 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024079 85028 SNHG12 http://www.ncbi.nlm.nih.gov/gene/?term=85028 "ASLNC04080, C1orf79, LINC00100, NCRNA00100 " lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024080 85028 SNHG12 http://www.ncbi.nlm.nih.gov/gene/?term=85028 "ASLNC04080, C1orf79, LINC00100, NCRNA00100 " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024081 850295 CHA1 http://www.ncbi.nlm.nih.gov/gene/?term=850295 YCL064C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024082 8502 PKP4 http://www.ncbi.nlm.nih.gov/gene/?term=8502 p0071 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024083 850305 PBN1 http://www.ncbi.nlm.nih.gov/gene/?term=850305 YCL052C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024084 850308 YCL049C http://www.ncbi.nlm.nih.gov/gene/?term=850308 YCL049C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024085 850312 EMC1 http://www.ncbi.nlm.nih.gov/gene/?term=850312 YCL045C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024086 850314 PDI1 http://www.ncbi.nlm.nih.gov/gene/?term=850314 "YCL043C, MFP1, TRG1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024087 850319 ATG22 http://www.ncbi.nlm.nih.gov/gene/?term=850319 "YCL038C, AUT4 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024088 850343 NFS1 http://www.ncbi.nlm.nih.gov/gene/?term=850343 "YCL017C, SPL1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024089 850348 ILV6 http://www.ncbi.nlm.nih.gov/gene/?term=850348 YCL009C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024090 850361 CIT2 http://www.ncbi.nlm.nih.gov/gene/?term=850361 YCR005C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024091 850361 CIT2 http://www.ncbi.nlm.nih.gov/gene/?term=850361 YCR005C mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024092 850375 YCR016W http://www.ncbi.nlm.nih.gov/gene/?term=850375 YCR016W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024093 850385 HSP30 http://www.ncbi.nlm.nih.gov/gene/?term=850385 "YCR021C, YRO1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024094 850389 PMP1 http://www.ncbi.nlm.nih.gov/gene/?term=850389 YCR024C-A mRNA Saccharomyces cerevisiae 18492794 Ribosome Yeast Fluorescence in situ hybridization "By this method, the majority of PMP1 transcript, either expressed from its genomic loci (PMP1) or from a plasmid (pPMP1), appeared mostly in the fraction of membrane-bound polysomes (Fig. 5A). " RLID00024095 8503 PIK3R3 http://www.ncbi.nlm.nih.gov/gene/?term=8503 "p55, p55-GAMMA, p55PIK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024096 8503 PIK3R3 http://www.ncbi.nlm.nih.gov/gene/?term=8503 "p55, p55-GAMMA, p55PIK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024097 850403 PHO87 http://www.ncbi.nlm.nih.gov/gene/?term=850403 YCR037C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024098 850432 ATG15 http://www.ncbi.nlm.nih.gov/gene/?term=850432 "YCR068W, AUT5, CVT17 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024099 850433 CPR4 http://www.ncbi.nlm.nih.gov/gene/?term=850433 "YCR069W, CYP4, SCC3, YCR070W " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024100 850456 CDC50 http://www.ncbi.nlm.nih.gov/gene/?term=850456 YCR094W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024101 850463 YCR099C http://www.ncbi.nlm.nih.gov/gene/?term=850463 YCR099C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024102 850476 YFL068W http://www.ncbi.nlm.nih.gov/gene/?term=850476 YFL068W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024103 850477 YFL067W http://www.ncbi.nlm.nih.gov/gene/?term=850477 YFL067W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024104 850478 YFL066C http://www.ncbi.nlm.nih.gov/gene/?term=850478 YFL066C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024105 850482 COS4 http://www.ncbi.nlm.nih.gov/gene/?term=850482 YFL062W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024106 850488 AAD6 http://www.ncbi.nlm.nih.gov/gene/?term=850488 "YFL056C, YFL057C " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024107 850502 FET5 http://www.ncbi.nlm.nih.gov/gene/?term=850502 YFL041W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024108 850505 YPT1 http://www.ncbi.nlm.nih.gov/gene/?term=850505 YFL038C mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization "As SEC4 mRNA is asymmetrically distributed to the bud prior to nuclear division, similar to ASH1 mRNA, we examined the localization of other POL mRNAs by FISH (Fig. 1B). Endogenous mRNAs encoding the Cdc42 and Rho3 GTPases (31); the Sec1, Sro7, and Sro77 SNARE regulators (23,25); the Sec3 and Exo84 exocyst components (27); and Ypt1, a GTPase involved in ER-Golgi transport, localized at least in part to the buds of G2/M phase cells prior to nuclear division. This pattern was discerned in �0% of cells for each mRNA examined (Fig. 1B), indicating that these mRNAs were also exported from mother cells. Asymmetric POL mRNA localization correlates with the bud-specific pattern of protein localization seen during cell division. " RLID00024109 850505 YPT1 http://www.ncbi.nlm.nih.gov/gene/?term=850505 YFL038C mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization Figure 1B: Endogenous mRNAs encoding bud-localized proteins also localize to the bud tip prior to nuclear division. WT yeast cells were treated as above and hybridized in situ with specific digoxigenin-labeled RNA antisense probes for different POL genes (as labeled). Representative small-budded (early G2/M) cells are shown. Data are collected from Figure 1B. RLID00024110 850505 YPT1 http://www.ncbi.nlm.nih.gov/gene/?term=850505 YFL038C mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024111 850518 STE2 http://www.ncbi.nlm.nih.gov/gene/?term=850518 YFL026W mRNA Saccharomyces cerevisiae 20457760 Cellular bud Yeast Fluorescence microscopy "In addition, we found that adding a single U3 element to the 3'end of STE2 mRNA was sufficient to localize STE2 mRNA to the distal tip of buds (Fig. S1). " RLID00024112 850527 LPD1 http://www.ncbi.nlm.nih.gov/gene/?term=850527 "YFL018C, HPD1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024113 850527 LPD1 http://www.ncbi.nlm.nih.gov/gene/?term=850527 "YFL018C, HPD1 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024114 850530 MDJ1 http://www.ncbi.nlm.nih.gov/gene/?term=850530 YFL016C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024115 850530 MDJ1 http://www.ncbi.nlm.nih.gov/gene/?term=850530 YFL016C mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024116 850536 HXT10 http://www.ncbi.nlm.nih.gov/gene/?term=850536 YFL011W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024117 850543 SEC4 http://www.ncbi.nlm.nih.gov/gene/?term=850543 "YFL005W, SRO6 " mRNA Saccharomyces cerevisiae 17339339 Endoplasmic reticulum Yeast RT-PCR "Importantly, mRNAs encoding Sec4, Cdc42, Sro7, and Snc1 were specifically enriched in the ER fraction, along with ASH1 mRNA (Fig. 9B), which was shown to be enriched on the ER (18). mRNAs encoding RDN18, a ribosomal rRNA, and TUB1 were found in both the ER and cytosolic fractions (Fig. 9B). " RLID00024118 850543 SEC4 http://www.ncbi.nlm.nih.gov/gene/?term=850543 "YFL005W, SRO6 " mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization Figure 1B: Endogenous mRNAs encoding bud-localized proteins also localize to the bud tip prior to nuclear division. WT yeast cells were treated as above and hybridized in situ with specific digoxigenin-labeled RNA antisense probes for different POL genes (as labeled). Representative small-budded (early G2/M) cells are shown. Data are collected from Figure 1B. RLID00024119 850543 SEC4 http://www.ncbi.nlm.nih.gov/gene/?term=850543 "YFL005W, SRO6 " mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization "As SEC4 mRNA is asymmetrically distributed to the bud prior to nuclear division, similar to ASH1 mRNA, we examined the localization of other POL mRNAs by FISH (Fig. ?(Fig.1B).1B). " RLID00024120 850543 SEC4 http://www.ncbi.nlm.nih.gov/gene/?term=850543 "YFL005W, SRO6 " mRNA Saccharomyces cerevisiae 17339339 Nucleus Yeast Fluorescence in situ hybridization "Cells in late G2/M also had SEC4 mRNA located in the nucleus of the mother cell. This may represent a maternal pool ofSEC4 mRNA yet to be exported. After mitosis, SEC4 mRNA was observed in both mother and daughter cells. " RLID00024121 850543 SEC4 http://www.ncbi.nlm.nih.gov/gene/?term=850543 "YFL005W, SRO6 " mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization "As most POL proteins are enriched in the bud, we examined the localization of their mRNAs during cell division by FISH with specific digoxigenin-labeled antisense probes (Fig. 1). First, we examined the localization of endogenous mRNA encoding Sec4 (Fig. 1A), a bud-localized GTPase that mediates secretory vesicle fusion with the plasma membrane, in WT cells. FISH labeling of endogenous SEC4 mRNA yielded single punctate structures located near the cell surface prior to budding (G1?phase). These structures were distinct from the nucleus, which was revealed by propidium iodide staining (Fig. 1A). In cells undergoing division (early G2/M phase), nearly all SEC4 mRNA was found in the bud even though nuclear division and segregation had yet to occur. This pattern was observed in 85% of the cells examined. Cells in late G2/M also had SEC4 mRNA located in the nucleus of the mother cell. This may represent a maternal pool ofSEC4 mRNA yet to be exported. After mitosis, SEC4 mRNA was observed in both mother and daughter cells. " RLID00024122 850543 SEC4 http://www.ncbi.nlm.nih.gov/gene/?term=850543 "YFL005W, SRO6 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024123 8505 PARG http://www.ncbi.nlm.nih.gov/gene/?term=8505 PARG99 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024124 8505 PARG http://www.ncbi.nlm.nih.gov/gene/?term=8505 PARG99 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024125 850602 ERJ5 http://www.ncbi.nlm.nih.gov/gene/?term=850602 YFR041C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024126 850605 DUG1 http://www.ncbi.nlm.nih.gov/gene/?term=850605 YFR044C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024127 850631 TPO1 http://www.ncbi.nlm.nih.gov/gene/?term=850631 YLL028W mRNA Saccharomyces cerevisiae 18805955 Cellular bud Yeast qRT-PCR "Khd1p associates with a subset of bud-tip-localized mRNAs. ASH1, MID2, and MTL1 mRNAs, but not BRO1 mRNA, were detected by RT-PCR in RNAs isolated from total extracts (Input) and from Khd1p-TAP affinity isolations (Khd1p).overexpression inhibits ASH1 expression (Irie et al. 2002). Therefore, we systematically examined whether Khd1p modifies protein expression of other bud-tip-localized mRNAs that are bound by Khd1p (MID2, MTL1, WSC2, SRL1, EGT2, and CLB2). " RLID00024128 850637 POM33 http://www.ncbi.nlm.nih.gov/gene/?term=850637 YLL023C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024129 850659 YLL067C http://www.ncbi.nlm.nih.gov/gene/?term=850659 YLL067C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024130 850660 YLL066C http://www.ncbi.nlm.nih.gov/gene/?term=850660 YLL066C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024131 850685 SDH2 http://www.ncbi.nlm.nih.gov/gene/?term=850685 "YLL041C, ACN17 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024132 850685 SDH2 http://www.ncbi.nlm.nih.gov/gene/?term=850685 "YLL041C, ACN17 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024133 850686 DNM1 http://www.ncbi.nlm.nih.gov/gene/?term=850686 YLL001W mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR TABLE 1: Localization of mRNAs encoding mitochondrial proteins in yeast. Data are collected from Table 1. RLID00024134 8506 CNTNAP1 http://www.ncbi.nlm.nih.gov/gene/?term=8506 "CASPR, CNTNAP, NRXN4, P190 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024135 850704 MEU1 http://www.ncbi.nlm.nih.gov/gene/?term=850704 YLR017W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024136 850706 PSR2 http://www.ncbi.nlm.nih.gov/gene/?term=850706 YLR019W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024137 850710 IZH3 http://www.ncbi.nlm.nih.gov/gene/?term=850710 YLR023C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024138 850714 AAT2 http://www.ncbi.nlm.nih.gov/gene/?term=850714 "YLR027C, ASP5 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024139 850714 AAT2 http://www.ncbi.nlm.nih.gov/gene/?term=850714 "YLR027C, ASP5 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024140 850745 ERG3 http://www.ncbi.nlm.nih.gov/gene/?term=850745 "YLR056W, PSO6, SYR1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024141 850770 GAL2 http://www.ncbi.nlm.nih.gov/gene/?term=850770 YLR081W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024142 850778 ALT1 http://www.ncbi.nlm.nih.gov/gene/?term=850778 YLR089C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024143 850782 NYV1 http://www.ncbi.nlm.nih.gov/gene/?term=850782 "YLR093C, MAM2 " mRNA Saccharomyces cerevisiae 23904265 Endoplasmic reticulum Yeast Confocal microscopy "We examined mRNA localization by confocal microscopy and found that 9 of 11 mSMPs tagged (ALG1, GOS1, ICE2, PEP12, PMT2, SUC2, SUR4, USE1, and YIP3) showed high levels of granule colocalization with ER (>70%; Figure 1 and Table 1), and 2 (NYV1 and SEC22) showed lower levels of ER localization (56%; Figure 1 and Table 1). A similar low level of ER localization was observed with two mRNAs that encode soluble SNAREs (SEC9 and SEC20) known to associate with the plasma and ER membranes (Figure 1 and Table 1). Of interest, some preference toward nER localization was observed with mSMPs such as PMT2, SUC2, SUR4, USE1, and YIP3, whereas in contrast, most of the mRNAs encoding SNAREs (e.g., GOS1, NYV1, PEP12, SEC9, and SEC22) demonstrated a preference for cER (Table 1). Data are collected from Table 1. " RLID00024144 850798 YLR108C http://www.ncbi.nlm.nih.gov/gene/?term=850798 YLR108C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024145 8507 ENC1 http://www.ncbi.nlm.nih.gov/gene/?term=8507 "CCL28, ENC-1, KLHL35, KLHL37, NRPB, PIG10, TP53I10 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024146 850811 YPS1 http://www.ncbi.nlm.nih.gov/gene/?term=850811 "YLR120C, YAP3 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024147 850829 NHA1 http://www.ncbi.nlm.nih.gov/gene/?term=850829 YLR138W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024148 850841 YLR149C http://www.ncbi.nlm.nih.gov/gene/?term=850841 YLR149C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024149 850844 PCD1 http://www.ncbi.nlm.nih.gov/gene/?term=850844 YLR151C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024150 850845 YLR152C http://www.ncbi.nlm.nih.gov/gene/?term=850845 YLR152C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024151 850871 IDP2 http://www.ncbi.nlm.nih.gov/gene/?term=850871 YLR174W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024152 850888 PEX13 http://www.ncbi.nlm.nih.gov/gene/?term=850888 "YLR191W, PAS20 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024153 850888 PEX13 http://www.ncbi.nlm.nih.gov/gene/?term=850888 "YLR191W, PAS20 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024154 850893 PWP1 http://www.ncbi.nlm.nih.gov/gene/?term=850893 YLR196W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024155 8508 NIPSNAP1 http://www.ncbi.nlm.nih.gov/gene/?term=8508 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024156 850900 MSS51 http://www.ncbi.nlm.nih.gov/gene/?term=850900 YLR203C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024157 850930 CDC42 http://www.ncbi.nlm.nih.gov/gene/?term=850930 YLR229C mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization "As SEC4 mRNA is asymmetrically distributed to the bud prior to nuclear division, similar to ASH1 mRNA, we examined the localization of other POL mRNAs by FISH (Fig. 1B). Endogenous mRNAs encoding the Cdc42 and Rho3 GTPases (31); the Sec1, Sro7, and Sro77 SNARE regulators (23,25); the Sec3 and Exo84 exocyst components (27); and Ypt1, a GTPase involved in ER-Golgi transport, localized at least in part to the buds of G2/M phase cells prior to nuclear division. This pattern was discerned in �0% of cells for each mRNA examined (Fig. 1B), indicating that these mRNAs were also exported from mother cells. Asymmetric POL mRNA localization correlates with the bud-specific pattern of protein localization seen during cell division. " RLID00024158 850930 CDC42 http://www.ncbi.nlm.nih.gov/gene/?term=850930 YLR229C mRNA Saccharomyces cerevisiae 17339339 Endoplasmic reticulum Yeast RT-PCR "Importantly, mRNAs encoding Sec4, Cdc42, Sro7, and Snc1 were specifically enriched in the ER fraction, along with ASH1 mRNA (Fig. 9B), which was shown to be enriched on the ER (18). mRNAs encoding RDN18, a ribosomal rRNA, and TUB1 were found in both the ER and cytosolic fractions (Fig. 9B). " RLID00024159 850930 CDC42 http://www.ncbi.nlm.nih.gov/gene/?term=850930 YLR229C mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization Figure 1B: Endogenous mRNAs encoding bud-localized proteins also localize to the bud tip prior to nuclear division. WT yeast cells were treated as above and hybridized in situ with specific digoxigenin-labeled RNA antisense probes for different POL genes (as labeled). Representative small-budded (early G2/M) cells are shown. Data are collected from Figure 1B. RLID00024160 850942 CSC1 http://www.ncbi.nlm.nih.gov/gene/?term=850942 YLR241W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024161 850952 SSP120 http://www.ncbi.nlm.nih.gov/gene/?term=850952 YLR250W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024162 850953 SYM1 http://www.ncbi.nlm.nih.gov/gene/?term=850953 YLR251W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024163 850963 HSP60 http://www.ncbi.nlm.nih.gov/gene/?term=850963 "YLR259C, CPN60, MIF4, MNA2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024164 850973 SEC22 http://www.ncbi.nlm.nih.gov/gene/?term=850973 "YLR268W, SLY2, TS26, TSL26 " mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024165 850973 SEC22 http://www.ncbi.nlm.nih.gov/gene/?term=850973 "YLR268W, SLY2, TS26, TSL26 " mRNA Saccharomyces cerevisiae 23904265 Endoplasmic reticulum Yeast Confocal microscopy "We examined mRNA localization by confocal microscopy and found that 9 of 11 mSMPs tagged (ALG1, GOS1, ICE2, PEP12, PMT2, SUC2, SUR4, USE1, and YIP3) showed high levels of granule colocalization with ER (>70%; Figure 1 and Table 1), and 2 (NYV1 and SEC22) showed lower levels of ER localization (56%; Figure 1 and Table 1). A similar low level of ER localization was observed with two mRNAs that encode soluble SNAREs (SEC9 and SEC20) known to associate with the plasma and ER membranes (Figure 1 and Table 1). Of interest, some preference toward nER localization was observed with mSMPs such as PMT2, SUC2, SUR4, USE1, and YIP3, whereas in contrast, most of the mRNAs encoding SNAREs (e.g., GOS1, NYV1, PEP12, SEC9, and SEC22) demonstrated a preference for cER (Table 1). Data are collected from Table 1. " RLID00024166 850990 ECI1 http://www.ncbi.nlm.nih.gov/gene/?term=850990 YLR284C mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024167 8509 NDST2 http://www.ncbi.nlm.nih.gov/gene/?term=8509 "HSST2, NST2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024168 851007 EXG1 http://www.ncbi.nlm.nih.gov/gene/?term=851007 "YLR300W, BGL1, SCW6 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024169 851013 ACO1 http://www.ncbi.nlm.nih.gov/gene/?term=851013 "YLR304C, GLU1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024170 851013 ACO1 http://www.ncbi.nlm.nih.gov/gene/?term=851013 "YLR304C, GLU1 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024171 851021 ATG39 http://www.ncbi.nlm.nih.gov/gene/?term=851021 YLR312C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024172 851042 MID2 http://www.ncbi.nlm.nih.gov/gene/?term=851042 "YLR332W, KAI1 " mRNA Saccharomyces cerevisiae 18805955 Cellular bud Yeast qRT-PCR "Khd1p colocalizes with a subset of mRNAs at the bud-tip of yeast cells.The U1A-GFP-tagged RNAs for ASH1, MID2, MTL1, and WSC2 colocalized with Khd1p, whereas BRO1 and TPO2 mRNAs did not colocalize. " RLID00024173 851069 ILV5 http://www.ncbi.nlm.nih.gov/gene/?term=851069 YLR355C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024174 851070 ATG33 http://www.ncbi.nlm.nih.gov/gene/?term=851070 YLR356W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024175 851087 ELO3 http://www.ncbi.nlm.nih.gov/gene/?term=851087 "YLR372W, APA1, SRE1, SUR4, VBM1 " mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024176 851087 ELO3 http://www.ncbi.nlm.nih.gov/gene/?term=851087 "YLR372W, APA1, SRE1, SUR4, VBM1 " mRNA Saccharomyces cerevisiae 23904265 Endoplasmic reticulum Yeast Confocal microscopy "We examined mRNA localization by confocal microscopy and found that 9 of 11 mSMPs tagged (ALG1, GOS1, ICE2, PEP12, PMT2, SUC2, SUR4, USE1, and YIP3) showed high levels of granule colocalization with ER (>70%; Figure 1 and Table 1), and 2 (NYV1 and SEC22) showed lower levels of ER localization (56%; Figure 1 and Table 1). A similar low level of ER localization was observed with two mRNAs that encode soluble SNAREs (SEC9 and SEC20) known to associate with the plasma and ER membranes (Figure 1 and Table 1). Of interest, some preference toward nER localization was observed with mSMPs such as PMT2, SUC2, SUR4, USE1, and YIP3, whereas in contrast, most of the mRNAs encoding SNAREs (e.g., GOS1, NYV1, PEP12, SEC9, and SEC22) demonstrated a preference for cER (Table 1). Data are collected from Table 1. " RLID00024177 851095 SEC61 http://www.ncbi.nlm.nih.gov/gene/?term=851095 YLR378C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024178 851095 SEC61 http://www.ncbi.nlm.nih.gov/gene/?term=851095 YLR378C mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024179 851107 CCW14 http://www.ncbi.nlm.nih.gov/gene/?term=851107 "YLR390W-A, SSR1, YLR391W, YLR391W-A " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024180 851109 ATP10 http://www.ncbi.nlm.nih.gov/gene/?term=851109 YLR393W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024181 851109 ATP10 http://www.ncbi.nlm.nih.gov/gene/?term=851109 YLR393W mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR "Out of 24 tagged mMPs, we found that the ATM1, ATP2, ATP10, CYB2, COX10,MDM10, and OXA1 mRNA granules exhibited very high levels of colocalization with mitochondria (e.g., >80%), while the CBS1, CYC3, and FIS1 mRNAs demonstrated low levels of colocalization (i.e., �4%) on glucose-containing medium (Fig. 1A; Table 1). Taken together, the data suggest that the 3�UTR is necessary for ATP2 and OXA1 mRNA localization to mitochondria (Table 3). " RLID00024182 851115 BDF1 http://www.ncbi.nlm.nih.gov/gene/?term=851115 YLR399C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024183 851132 PUN1 http://www.ncbi.nlm.nih.gov/gene/?term=851132 YLR414C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024184 851187 YRF1-4 http://www.ncbi.nlm.nih.gov/gene/?term=851187 "YLR466W, YRF1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024185 851192 CYC3 http://www.ncbi.nlm.nih.gov/gene/?term=851192 YAL039C mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR TABLE 1: Localization of mRNAs encoding mitochondrial proteins in yeast. Data are collected from Table 1. RLID00024186 851203 SNC1 http://www.ncbi.nlm.nih.gov/gene/?term=851203 YAL030W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024187 851203 SNC1 http://www.ncbi.nlm.nih.gov/gene/?term=851203 YAL030W mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization "As SEC4 mRNA is asymmetrically distributed to the bud prior to nuclear division, similar to ASH1 mRNA, we examined the localization of other POL mRNAs by FISH (Fig. 1B). Endogenous mRNAs encoding the Cdc42 and Rho3 GTPases (31); the Sec1, Sro7, and Sro77 SNARE regulators (23,25); the Sec3 and Exo84 exocyst components (27); and Ypt1, a GTPase involved in ER-Golgi transport, localized at least in part to the buds of G2/M phase cells prior to nuclear division. This pattern was discerned in �0% of cells for each mRNA examined (Fig. 1B), indicating that these mRNAs were also exported from mother cells. Asymmetric POL mRNA localization correlates with the bud-specific pattern of protein localization seen during cell division. " RLID00024188 851203 SNC1 http://www.ncbi.nlm.nih.gov/gene/?term=851203 YAL030W mRNA Saccharomyces cerevisiae 17339339 Endoplasmic reticulum Yeast RT-PCR "Importantly, mRNAs encoding Sec4, Cdc42, Sro7, and Snc1 were specifically enriched in the ER fraction, along with ASH1 mRNA (Fig. 9B), which was shown to be enriched on the ER (18). mRNAs encoding RDN18, a ribosomal rRNA, and TUB1 were found in both the ER and cytosolic fractions (Fig. 9B). " RLID00024189 851203 SNC1 http://www.ncbi.nlm.nih.gov/gene/?term=851203 YAL030W mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization Figure 1B: Endogenous mRNAs encoding bud-localized proteins also localize to the bud tip prior to nuclear division. WT yeast cells were treated as above and hybridized in situ with specific digoxigenin-labeled RNA antisense probes for different POL genes (as labeled). Representative small-budded (early G2/M) cells are shown. Data are collected from Figure 1B. RLID00024190 851203 SNC1 http://www.ncbi.nlm.nih.gov/gene/?term=851203 YAL030W mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024191 851210 PMT2 http://www.ncbi.nlm.nih.gov/gene/?term=851210 "YAL023C, FUN25 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024192 851210 PMT2 http://www.ncbi.nlm.nih.gov/gene/?term=851210 "YAL023C, FUN25 " mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024193 851210 PMT2 http://www.ncbi.nlm.nih.gov/gene/?term=851210 "YAL023C, FUN25 " mRNA Saccharomyces cerevisiae 23904265 Endoplasmic reticulum Yeast Confocal microscopy "We examined mRNA localization by confocal microscopy and found that 9 of 11 mSMPs tagged (ALG1, GOS1, ICE2, PEP12, PMT2, SUC2, SUR4, USE1, and YIP3) showed high levels of granule colocalization with ER (>70%; Figure 1 and Table 1), and 2 (NYV1 and SEC22) showed lower levels of ER localization (56%; Figure 1 and Table 1). A similar low level of ER localization was observed with two mRNAs that encode soluble SNAREs (SEC9 and SEC20) known to associate with the plasma and ER membranes (Figure 1 and Table 1). Of interest, some preference toward nER localization was observed with mSMPs such as PMT2, SUC2, SUR4, USE1, and YIP3, whereas in contrast, most of the mRNAs encoding SNAREs (e.g., GOS1, NYV1, PEP12, SEC9, and SEC22) demonstrated a preference for cER (Table 1). Data are collected from Table 1. " RLID00024194 851211 FUN26 http://www.ncbi.nlm.nih.gov/gene/?term=851211 YAL022C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024195 851223 MDM10 http://www.ncbi.nlm.nih.gov/gene/?term=851223 "YAL010C, FUN37 " mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR TABLE 1: Localization of mRNAs encoding mitochondrial proteins in yeast. Data are collected from Table 1. RLID00024196 851226 ERP2 http://www.ncbi.nlm.nih.gov/gene/?term=851226 YAL007C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024197 851238 BDH2 http://www.ncbi.nlm.nih.gov/gene/?term=851238 YAL061W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024198 851246 FLC2 http://www.ncbi.nlm.nih.gov/gene/?term=851246 YAL053W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024199 851256 ERV46 http://www.ncbi.nlm.nih.gov/gene/?term=851256 "YAL042W, FUN9 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024200 851279 UIP3 http://www.ncbi.nlm.nih.gov/gene/?term=851279 YAR027W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024201 851282 PRM9 http://www.ncbi.nlm.nih.gov/gene/?term=851282 YAR031W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024202 851292 YAR061W http://www.ncbi.nlm.nih.gov/gene/?term=851292 "YAR061W, YAR062W " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024203 851304 FMP45 http://www.ncbi.nlm.nih.gov/gene/?term=851304 YDL222C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024204 851308 YDL218W http://www.ncbi.nlm.nih.gov/gene/?term=851308 YDL218W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024205 851314 SHR3 http://www.ncbi.nlm.nih.gov/gene/?term=851314 "YDL212W, APF1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024206 851323 RTN2 http://www.ncbi.nlm.nih.gov/gene/?term=851323 YDL204W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024207 851348 COS7 http://www.ncbi.nlm.nih.gov/gene/?term=851348 YDL248W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024208 851352 HXT15 http://www.ncbi.nlm.nih.gov/gene/?term=851352 YDL245C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024209 851376 DLD2 http://www.ncbi.nlm.nih.gov/gene/?term=851376 "YDL178W, AIP2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024210 851380 DLD1 http://www.ncbi.nlm.nih.gov/gene/?term=851380 YDL174C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024211 851415 RPO21 http://www.ncbi.nlm.nih.gov/gene/?term=851415 "YDL140C, RPB1, RPB220, SUA8 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024212 851429 VCX1 http://www.ncbi.nlm.nih.gov/gene/?term=851429 "YDL128W, HUM1, MNR1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024213 851462 PMT1 http://www.ncbi.nlm.nih.gov/gene/?term=851462 YDL095W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024214 851481 MDH3 http://www.ncbi.nlm.nih.gov/gene/?term=851481 YDL078C mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024215 851487 YET3 http://www.ncbi.nlm.nih.gov/gene/?term=851487 YDL072C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024216 851488 BDF2 http://www.ncbi.nlm.nih.gov/gene/?term=851488 YDL070W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024217 851491 CBS1 http://www.ncbi.nlm.nih.gov/gene/?term=851491 YDL069C mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR TABLE 1: Localization of mRNAs encoding mitochondrial proteins in yeast. Data are collected from Table 1. RLID00024218 851491 CBS1 http://www.ncbi.nlm.nih.gov/gene/?term=851491 YDL069C mRNA Saccharomyces cerevisiae 25971974 Mitochondrion Ski2 cell Northern blot The tRNA splicing endonuclease complex cleaves the mitochondria-localized CBP1 mRNA. RLID00024219 851493 IDP1 http://www.ncbi.nlm.nih.gov/gene/?term=851493 YDL066W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024220 8514 KCNAB2 http://www.ncbi.nlm.nih.gov/gene/?term=8514 "AKR6A5, HKvbeta2, HKvbeta2.1, HKvbeta2.2, KCNA2B, KV-BETA-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024221 851506 MCH1 http://www.ncbi.nlm.nih.gov/gene/?term=851506 YDL054C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024222 851514 NPC2 http://www.ncbi.nlm.nih.gov/gene/?term=851514 YDL046W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024223 851516 FAD1 http://www.ncbi.nlm.nih.gov/gene/?term=851516 YDL045C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024224 851527 GPR1 http://www.ncbi.nlm.nih.gov/gene/?term=851527 YDL035C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024225 851535 MRX9 http://www.ncbi.nlm.nih.gov/gene/?term=851535 YDL027C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024226 851537 DIA3 http://www.ncbi.nlm.nih.gov/gene/?term=851537 YDL024C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024227 851539 GPD1 http://www.ncbi.nlm.nih.gov/gene/?term=851539 "YDL022W, DAR1, HOR1, OSG1, OSR5 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024228 851539 GPD1 http://www.ncbi.nlm.nih.gov/gene/?term=851539 "YDL022W, DAR1, HOR1, OSG1, OSR5 " mRNA Saccharomyces cerevisiae 19903887 Endoplasmic reticulum Yeast RT-PCR "To further analyze the specificity of mPP targeting, we examined the localization of the POX1 and GPD1 mRNAs in cells expressing Sec63-RFP (Fig. S1 B and C and Table S3). Interestingly, a high percentage of both RNAs colocalized with Sec63-RFP (59% and 71%, respectively; Table S3 and Fig. S1B and C). While mRNA localization to the ER could be due to the fact that ER fills much of the cell volume (see, e.g., Fig. S1B and C), we also demonstrated that peroxisomes decorate both nuclear and cortical ER (Fig. S1D). Thus, discerning whether mPP localization to the ER results from a direct association with ER membranes or is a consequence of binding to ER-associated peroxisomes is difficult. Alternatively, GPD1 mRNA, which encodes a glycerol-3-phosphate dehydrogenase found in the cytosol and peroxisomes, may preferentially localize to ER-like mRNAs encoding cytoplasmic proteins (13). This could allow for protein distribution to either compartment. Data are collected from Table S3: Localization of mPPs to ER. " RLID00024229 851539 GPD1 http://www.ncbi.nlm.nih.gov/gene/?term=851539 "YDL022W, DAR1, HOR1, OSG1, OSR5 " mRNA Saccharomyces cerevisiae 19903887 Cell cortex Yeast RT-PCR "To further analyze the specificity of mPP targeting, we examined the localization of the POX1 and GPD1 mRNAs in cells expressing Sec63-RFP (Fig. S1 B and C and Table S3). Interestingly, a high percentage of both RNAs colocalized with Sec63-RFP (59% and 71%, respectively; Table S3 and Fig. S1B and C). While mRNA localization to the ER could be due to the fact that ER fills much of the cell volume (see, e.g., Fig. S1B and C), we also demonstrated that peroxisomes decorate both nuclear and cortical ER (Fig. S1D). Thus, discerning whether mPP localization to the ER results from a direct association with ER membranes or is a consequence of binding to ER-associated peroxisomes is difficult. Alternatively, GPD1 mRNA, which encodes a glycerol-3-phosphate dehydrogenase found in the cytosol and peroxisomes, may preferentially localize to ER-like mRNAs encoding cytoplasmic proteins (13). This could allow for protein distribution to either compartment. Data are collected from Table S3: Localization of mPPs to ER. " RLID00024230 851547 TSC13 http://www.ncbi.nlm.nih.gov/gene/?term=851547 YDL015C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024231 851551 GRX6 http://www.ncbi.nlm.nih.gov/gene/?term=851551 YDL010W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024232 851560 ATP16 http://www.ncbi.nlm.nih.gov/gene/?term=851560 YDL004W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024233 851566 RCR2 http://www.ncbi.nlm.nih.gov/gene/?term=851566 "YDR003W, SSH5 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024234 851570 TRP1 http://www.ncbi.nlm.nih.gov/gene/?term=851570 YDR007W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024235 851581 YDR018C http://www.ncbi.nlm.nih.gov/gene/?term=851581 YDR018C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024236 851582 GCV1 http://www.ncbi.nlm.nih.gov/gene/?term=851582 "YDR019C, GSD1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024237 851597 MRH1 http://www.ncbi.nlm.nih.gov/gene/?term=851597 YDR033W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024238 851608 ENA5 http://www.ncbi.nlm.nih.gov/gene/?term=851608 YDR038C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024239 851609 ENA2 http://www.ncbi.nlm.nih.gov/gene/?term=851609 YDR039C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024240 851610 ENA1 http://www.ncbi.nlm.nih.gov/gene/?term=851610 "YDR040C, HOR6, PMR2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024241 851611 RSM10 http://www.ncbi.nlm.nih.gov/gene/?term=851611 YDR041W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024242 851616 BAP3 http://www.ncbi.nlm.nih.gov/gene/?term=851616 "YDR046C, PAP1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024243 851625 PST1 http://www.ncbi.nlm.nih.gov/gene/?term=851625 "YDR055W, HPF2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024244 851626 EMC10 http://www.ncbi.nlm.nih.gov/gene/?term=851626 YDR056C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024245 851627 YOS9 http://www.ncbi.nlm.nih.gov/gene/?term=851627 YDR057W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024246 851634 LCB2 http://www.ncbi.nlm.nih.gov/gene/?term=851634 "YDR062W, SCS1, TSC1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024247 851649 SED1 http://www.ncbi.nlm.nih.gov/gene/?term=851649 YDR077W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024248 851677 TVP15 http://www.ncbi.nlm.nih.gov/gene/?term=851677 YDR100W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024249 851687 YDR109C http://www.ncbi.nlm.nih.gov/gene/?term=851687 YDR109C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024250 851694 MRPL1 http://www.ncbi.nlm.nih.gov/gene/?term=851694 YDR116C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024251 851701 INO2 http://www.ncbi.nlm.nih.gov/gene/?term=851701 "YDR123C, DIE1, SCS1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024252 851726 KGD2 http://www.ncbi.nlm.nih.gov/gene/?term=851726 YDR148C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024253 851726 KGD2 http://www.ncbi.nlm.nih.gov/gene/?term=851726 YDR148C mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024254 851742 SEC1 http://www.ncbi.nlm.nih.gov/gene/?term=851742 YDR164C mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization "As SEC4 mRNA is asymmetrically distributed to the bud prior to nuclear division, similar to ASH1 mRNA, we examined the localization of other POL mRNAs by FISH (Fig. 1B). Endogenous mRNAs encoding the Cdc42 and Rho3 GTPases (31); the Sec1, Sro7, and Sro77 SNARE regulators (23,25); the Sec3 and Exo84 exocyst components (27); and Ypt1, a GTPase involved in ER-Golgi transport, localized at least in part to the buds of G2/M phase cells prior to nuclear division. This pattern was discerned in �0% of cells for each mRNA examined (Fig. 1B), indicating that these mRNAs were also exported from mother cells. Asymmetric POL mRNA localization correlates with the bud-specific pattern of protein localization seen during cell division. " RLID00024255 851742 SEC1 http://www.ncbi.nlm.nih.gov/gene/?term=851742 YDR164C mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization Figure 1B: Endogenous mRNAs encoding bud-localized proteins also localize to the bud tip prior to nuclear division. WT yeast cells were treated as above and hybridized in situ with specific digoxigenin-labeled RNA antisense probes for different POL genes (as labeled). Representative small-budded (early G2/M) cells are shown. Data are collected from Figure 1B. RLID00024256 851756 NGG1 http://www.ncbi.nlm.nih.gov/gene/?term=851756 "YDR176W, ADA3, SWI7 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024257 851763 CDC1 http://www.ncbi.nlm.nih.gov/gene/?term=851763 "YDR182W, DSC1, DSR1, ESP2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024258 851775 MSS116 http://www.ncbi.nlm.nih.gov/gene/?term=851775 YDR194C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024259 851785 COQ4 http://www.ncbi.nlm.nih.gov/gene/?term=851785 YDR204W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024260 851807 GTB1 http://www.ncbi.nlm.nih.gov/gene/?term=851807 YDR221W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024261 851819 RTN1 http://www.ncbi.nlm.nih.gov/gene/?term=851819 YDR233C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024262 851831 PEX5 http://www.ncbi.nlm.nih.gov/gene/?term=851831 "YDR244W, PAS10 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024263 851831 PEX5 http://www.ncbi.nlm.nih.gov/gene/?term=851831 "YDR244W, PAS10 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024264 851843 CTA1 http://www.ncbi.nlm.nih.gov/gene/?term=851843 YDR256C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024265 851843 CTA1 http://www.ncbi.nlm.nih.gov/gene/?term=851843 YDR256C mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024266 851843 CTA1 http://www.ncbi.nlm.nih.gov/gene/?term=851843 YDR256C mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024267 851855 YDR262W http://www.ncbi.nlm.nih.gov/gene/?term=851855 YDR262W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024268 851857 AKR1 http://www.ncbi.nlm.nih.gov/gene/?term=851857 YDR264C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024269 851858 PEX10 http://www.ncbi.nlm.nih.gov/gene/?term=851858 "YDR265W, PAS4 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024270 851866 DON1 http://www.ncbi.nlm.nih.gov/gene/?term=851866 YDR273W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024271 851868 BSC2 http://www.ncbi.nlm.nih.gov/gene/?term=851868 YDR275W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024272 851878 DPP1 http://www.ncbi.nlm.nih.gov/gene/?term=851878 "YDR284C, ZRG1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024273 851888 DPL1 http://www.ncbi.nlm.nih.gov/gene/?term=851888 "YDR294C, BST1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024274 8518 IKBKAP http://www.ncbi.nlm.nih.gov/gene/?term=8518 "DYS, ELP1, FD, IKAP, IKI3, TOT1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024275 8518 IKBKAP http://www.ncbi.nlm.nih.gov/gene/?term=8518 "DYS, ELP1, FD, IKAP, IKI3, TOT1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024276 8518 IKBKAP http://www.ncbi.nlm.nih.gov/gene/?term=8518 "DYS, ELP1, FD, IKAP, IKI3, TOT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024277 851902 PMT7 http://www.ncbi.nlm.nih.gov/gene/?term=851902 YDR307W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024278 851929 PEX3 http://www.ncbi.nlm.nih.gov/gene/?term=851929 "YDR329C, PAS3 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024279 851929 PEX3 http://www.ncbi.nlm.nih.gov/gene/?term=851929 "YDR329C, PAS3 " mRNA Saccharomyces cerevisiae 17417645 Endoplasmic reticulum Yeast qRT-PCR "We previously demonstrated that SRO7 mRNA undergoes polarized transport, along with cortical ER, to the bud tip11. Thus, PEX3 mRNA localizes to the endoplasmic reticulum, as seen previously11, and Pex3 is functional after MS2L integration into the PEX3 locus. We observed typical tubular-punctate mitochondrial morphology with Oxa1-RFP19. " RLID00024280 851929 PEX3 http://www.ncbi.nlm.nih.gov/gene/?term=851929 "YDR329C, PAS3 " mRNA Saccharomyces cerevisiae 19903887 Endoplasmic reticulum Yeast RT-PCR "To further analyze the specificity of mPP targeting, we examined the localization of the POX1 and GPD1 mRNAs in cells expressing Sec63-RFP (Fig. S1 B and C and Table S3). Interestingly, a high percentage of both RNAs colocalized with Sec63-RFP (59% and 71%, respectively; Table S3 and Fig. S1B and C). While mRNA localization to the ER could be due to the fact that ER fills much of the cell volume (see, e.g., Fig. S1B and C), we also demonstrated that peroxisomes decorate both nuclear and cortical ER (Fig. S1D). Thus, discerning whether mPP localization to the ER results from a direct association with ER membranes or is a consequence of binding to ER-associated peroxisomes is difficult. Alternatively, GPD1 mRNA, which encodes a glycerol-3-phosphate dehydrogenase found in the cytosol and peroxisomes, may preferentially localize to ER-like mRNAs encoding cytoplasmic proteins (13). This could allow for protein distribution to either compartment. Data are collected from Table S3: Localization of mPPs to ER. " RLID00024281 851929 PEX3 http://www.ncbi.nlm.nih.gov/gene/?term=851929 "YDR329C, PAS3 " mRNA Saccharomyces cerevisiae 19903887 Cell cortex Yeast RT-PCR "To further analyze the specificity of mPP targeting, we examined the localization of the POX1 and GPD1 mRNAs in cells expressing Sec63-RFP (Fig. S1 B and C and Table S3). Interestingly, a high percentage of both RNAs colocalized with Sec63-RFP (59% and 71%, respectively; Table S3 and Fig. S1B and C). While mRNA localization to the ER could be due to the fact that ER fills much of the cell volume (see, e.g., Fig. S1B and C), we also demonstrated that peroxisomes decorate both nuclear and cortical ER (Fig. S1D). Thus, discerning whether mPP localization to the ER results from a direct association with ER membranes or is a consequence of binding to ER-associated peroxisomes is difficult. Alternatively, GPD1 mRNA, which encodes a glycerol-3-phosphate dehydrogenase found in the cytosol and peroxisomes, may preferentially localize to ER-like mRNAs encoding cytoplasmic proteins (13). This could allow for protein distribution to either compartment. Data are collected from Table S3: Localization of mPPs to ER. " RLID00024282 851929 PEX3 http://www.ncbi.nlm.nih.gov/gene/?term=851929 "YDR329C, PAS3 " mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024283 851929 PEX3 http://www.ncbi.nlm.nih.gov/gene/?term=851929 "YDR329C, PAS3 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024284 851931 GPI8 http://www.ncbi.nlm.nih.gov/gene/?term=851931 YDR331W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024285 851943 HXT7 http://www.ncbi.nlm.nih.gov/gene/?term=851943 YDR342C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024286 851944 HXT6 http://www.ncbi.nlm.nih.gov/gene/?term=851944 YDR343C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024287 851946 HXT3 http://www.ncbi.nlm.nih.gov/gene/?term=851946 YDR345C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024288 8519 IFITM1 http://www.ncbi.nlm.nih.gov/gene/?term=8519 "9-27, CD225, DSPA2a, IFI17, LEU13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024289 8519 IFITM1 http://www.ncbi.nlm.nih.gov/gene/?term=8519 "9-27, CD225, DSPA2a, IFI17, LEU13 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024290 852044 GPI17 http://www.ncbi.nlm.nih.gov/gene/?term=852044 YDR434W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024291 852063 PPN1 http://www.ncbi.nlm.nih.gov/gene/?term=852063 "YDR452W, PHM5 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024292 852066 NHX1 http://www.ncbi.nlm.nih.gov/gene/?term=852066 "YDR456W, NHA2, VPL27, VPS44 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024293 852090 PEX29 http://www.ncbi.nlm.nih.gov/gene/?term=852090 YDR479C mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024294 852092 PHO8 http://www.ncbi.nlm.nih.gov/gene/?term=852092 YDR481C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024295 852094 KRE2 http://www.ncbi.nlm.nih.gov/gene/?term=852094 "YDR483W, MNT1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024296 8520 HAT1 http://www.ncbi.nlm.nih.gov/gene/?term=8520 KAT1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024297 8520 HAT1 http://www.ncbi.nlm.nih.gov/gene/?term=8520 KAT1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024298 8520 HAT1 http://www.ncbi.nlm.nih.gov/gene/?term=8520 KAT1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024299 852108 ITR1 http://www.ncbi.nlm.nih.gov/gene/?term=852108 YDR497C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024300 852109 SEC20 http://www.ncbi.nlm.nih.gov/gene/?term=852109 YDR498C mRNA Saccharomyces cerevisiae 23904265 Endoplasmic reticulum Yeast Confocal microscopy "We examined mRNA localization by confocal microscopy and found that 9 of 11 mSMPs tagged (ALG1, GOS1, ICE2, PEP12, PMT2, SUC2, SUR4, USE1, and YIP3) showed high levels of granule colocalization with ER (>70%; Figure 1 and Table 1), and 2 (NYV1 and SEC22) showed lower levels of ER localization (56%; Figure 1 and Table 1). A similar low level of ER localization was observed with two mRNAs that encode soluble SNAREs (SEC9 and SEC20) known to associate with the plasma and ER membranes (Figure 1 and Table 1). Of interest, some preference toward nER localization was observed with mSMPs such as PMT2, SUC2, SUR4, USE1, and YIP3, whereas in contrast, most of the mRNAs encoding SNAREs (e.g., GOS1, NYV1, PEP12, SEC9, and SEC22) demonstrated a preference for cER (Table 1). Data are collected from Table 1. " RLID00024301 852114 LPP1 http://www.ncbi.nlm.nih.gov/gene/?term=852114 YDR503C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024302 852121 GNP1 http://www.ncbi.nlm.nih.gov/gene/?term=852121 YDR508C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024303 852123 SDH7 http://www.ncbi.nlm.nih.gov/gene/?term=852123 "YDR511W, ACN9 " mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR TABLE 1: Localization of mRNAs encoding mitochondrial proteins in yeast. Data are collected from Table 1. RLID00024304 852149 STL1 http://www.ncbi.nlm.nih.gov/gene/?term=852149 YDR536W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024305 852158 YRF1-1 http://www.ncbi.nlm.nih.gov/gene/?term=852158 "YDR545W, YRF1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024306 852159 YBL113C http://www.ncbi.nlm.nih.gov/gene/?term=852159 YBL113C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024307 852160 YBL112C http://www.ncbi.nlm.nih.gov/gene/?term=852160 YBL112C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024308 852161 YBL111C http://www.ncbi.nlm.nih.gov/gene/?term=852161 YBL111C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024309 852168 SRO77 http://www.ncbi.nlm.nih.gov/gene/?term=852168 "YBL106C, SNI2, SOP2 " mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization "As SEC4 mRNA is asymmetrically distributed to the bud prior to nuclear division, similar to ASH1 mRNA, we examined the localization of other POL mRNAs by FISH (Fig. 1B). Endogenous mRNAs encoding the Cdc42 and Rho3 GTPases (31); the Sec1, Sro7, and Sro77 SNARE regulators (23,25); the Sec3 and Exo84 exocyst components (27); and Ypt1, a GTPase involved in ER-Golgi transport, localized at least in part to the buds of G2/M phase cells prior to nuclear division. This pattern was discerned in �0% of cells for each mRNA examined (Fig. 1B), indicating that these mRNAs were also exported from mother cells. Asymmetric POL mRNA localization correlates with the bud-specific pattern of protein localization seen during cell division. " RLID00024310 852168 SRO77 http://www.ncbi.nlm.nih.gov/gene/?term=852168 "YBL106C, SNI2, SOP2 " mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization Figure 1B: Endogenous mRNAs encoding bud-localized proteins also localize to the bud tip prior to nuclear division. WT yeast cells were treated as above and hybridized in situ with specific digoxigenin-labeled RNA antisense probes for different POL genes (as labeled). Representative small-budded (early G2/M) cells are shown. Data are collected from Figure 1B. RLID00024311 852173 ECM21 http://www.ncbi.nlm.nih.gov/gene/?term=852173 "YBL101C, ART2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024312 852177 ATP1 http://www.ncbi.nlm.nih.gov/gene/?term=852177 YBL099W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024313 852177 ATP1 http://www.ncbi.nlm.nih.gov/gene/?term=852177 YBL099W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024314 852179 BNA4 http://www.ncbi.nlm.nih.gov/gene/?term=852179 YBL098W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024315 8521 GCM1 http://www.ncbi.nlm.nih.gov/gene/?term=8521 "GCMA, hGCMa " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024316 8521 GCM1 http://www.ncbi.nlm.nih.gov/gene/?term=8521 "GCMA, hGCMa " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024317 852200 ATG8 http://www.ncbi.nlm.nih.gov/gene/?term=852200 "YBL078C, APG8, AUT7, CVT5 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024318 852215 PRX1 http://www.ncbi.nlm.nih.gov/gene/?term=852215 YBL064C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024319 852235 COR1 http://www.ncbi.nlm.nih.gov/gene/?term=852235 "YBL045C, QCR1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024320 852235 COR1 http://www.ncbi.nlm.nih.gov/gene/?term=852235 "YBL045C, QCR1 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024321 852259 PIM1 http://www.ncbi.nlm.nih.gov/gene/?term=852259 YBL022C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024322 852264 PEP1 http://www.ncbi.nlm.nih.gov/gene/?term=852264 "YBL017C, VPS10, VPT1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024323 852266 ACH1 http://www.ncbi.nlm.nih.gov/gene/?term=852266 YBL015W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024324 852271 SCT1 http://www.ncbi.nlm.nih.gov/gene/?term=852271 "YBL011W, GAT2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024325 852292 DSF2 http://www.ncbi.nlm.nih.gov/gene/?term=852292 YBR007C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024326 8522 GAS7 http://www.ncbi.nlm.nih.gov/gene/?term=8522 MLL/GAS7 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024327 8522 GAS7 http://www.ncbi.nlm.nih.gov/gene/?term=8522 MLL/GAS7 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024328 8522 GAS7 http://www.ncbi.nlm.nih.gov/gene/?term=8522 MLL/GAS7 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024329 852302 GRX7 http://www.ncbi.nlm.nih.gov/gene/?term=852302 YBR014C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024330 852311 CHS3 http://www.ncbi.nlm.nih.gov/gene/?term=852311 "YBR023C, CAL1, CSD2, DIT101, KTI2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024331 852314 ETR1 http://www.ncbi.nlm.nih.gov/gene/?term=852314 "YBR026C, MRF1, MRF1' " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024332 852324 CSG2 http://www.ncbi.nlm.nih.gov/gene/?term=852324 "YBR036C, CLS2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024333 852325 SCO1 http://www.ncbi.nlm.nih.gov/gene/?term=852325 "YBR037C, PET161 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024334 852327 ATP3 http://www.ncbi.nlm.nih.gov/gene/?term=852327 YBR039W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024335 852327 ATP3 http://www.ncbi.nlm.nih.gov/gene/?term=852327 YBR039W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024336 852329 FAT1 http://www.ncbi.nlm.nih.gov/gene/?term=852329 YBR041W mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024337 852329 FAT1 http://www.ncbi.nlm.nih.gov/gene/?term=852329 YBR041W mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024338 852332 TCM62 http://www.ncbi.nlm.nih.gov/gene/?term=852332 YBR044C mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024339 852335 ZTA1 http://www.ncbi.nlm.nih.gov/gene/?term=852335 YBR046C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024340 852343 YRO2 http://www.ncbi.nlm.nih.gov/gene/?term=852343 YBR054W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024341 852360 BAP2 http://www.ncbi.nlm.nih.gov/gene/?term=852360 YBR068C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024342 852366 PFF1 http://www.ncbi.nlm.nih.gov/gene/?term=852366 "YBR074W, YBR075W " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024343 85236 HIST1H2BK http://www.ncbi.nlm.nih.gov/gene/?term=85236 "H2B/S, H2BFAiii, H2BFT, H2BK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024344 85236 HIST1H2BK http://www.ncbi.nlm.nih.gov/gene/?term=85236 "H2B/S, H2BFAiii, H2BFT, H2BK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024345 852370 ECM33 http://www.ncbi.nlm.nih.gov/gene/?term=852370 YBR078W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024346 852382 IST2 http://www.ncbi.nlm.nih.gov/gene/?term=852382 YBR086C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024347 852382 IST2 http://www.ncbi.nlm.nih.gov/gene/?term=852382 YBR086C mRNA Saccharomyces cerevisiae 14691136 Cellular bud Yeast In situ hybridization "We found that IST2 mRNA localized to the bud tip in wild-type cells and in an aux1Δ mutant, lacking the entire AUX1 gene (Fig. 8 A). Similar results were obtained when the localization of ASH1 mRNA was examined (not depicted). " RLID00024348 852382 IST2 http://www.ncbi.nlm.nih.gov/gene/?term=852382 YBR086C mRNA Saccharomyces cerevisiae 20713510 Cellular bud Yeast Chip-seq "In yeast, the RNA-binding protein She2p binds several mRNAs and targets them for localization at the bud. Here we report that She2p is recruited cotranscriptionally to the nascent bud-localized ASH1, IST2, and EAR1 mRNA. " RLID00024349 852382 IST2 http://www.ncbi.nlm.nih.gov/gene/?term=852382 YBR086C mRNA Saccharomyces cerevisiae 22994588 Cytoplasm Yeast qRT-PCR "Figure 2. Deletion of AUX1 perturbs localization of WSC2, IST2, SRL1 and EAR1 mRNAs. Arrowheads indicate cytoplasmic mRNPs with tagged WSC2, IST2 or EAR1 mRNA. " RLID00024350 852389 PHO3 http://www.ncbi.nlm.nih.gov/gene/?term=852389 YBR092C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024351 852393 YBR096W http://www.ncbi.nlm.nih.gov/gene/?term=852393 YBR096W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024352 852398 EXO84 http://www.ncbi.nlm.nih.gov/gene/?term=852398 "YBR102C, USA3 " mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization "As SEC4 mRNA is asymmetrically distributed to the bud prior to nuclear division, similar to ASH1 mRNA, we examined the localization of other POL mRNAs by FISH (Fig. 1B). Endogenous mRNAs encoding the Cdc42 and Rho3 GTPases (31); the Sec1, Sro7, and Sro77 SNARE regulators (23,25); the Sec3 and Exo84 exocyst components (27); and Ypt1, a GTPase involved in ER-Golgi transport, localized at least in part to the buds of G2/M phase cells prior to nuclear division. This pattern was discerned in �0% of cells for each mRNA examined (Fig. 1B), indicating that these mRNAs were also exported from mother cells. Asymmetric POL mRNA localization correlates with the bud-specific pattern of protein localization seen during cell division. " RLID00024353 852398 EXO84 http://www.ncbi.nlm.nih.gov/gene/?term=852398 "YBR102C, USA3 " mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization Figure 1B: Endogenous mRNAs encoding bud-localized proteins also localize to the bud tip prior to nuclear division. WT yeast cells were treated as above and hybridized in situ with specific digoxigenin-labeled RNA antisense probes for different POL genes (as labeled). Representative small-budded (early G2/M) cells are shown. RLID00024354 852398 EXO84 http://www.ncbi.nlm.nih.gov/gene/?term=852398 "YBR102C, USA3 " mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization Figure 1B: Endogenous mRNAs encoding bud-localized proteins also localize to the bud tip prior to nuclear division. WT yeast cells were treated as above and hybridized in situ with specific digoxigenin-labeled RNA antisense probes for different POL genes (as labeled). Representative small-budded (early G2/M) cells are shown. Data are collected from Figure 1B. RLID00024355 852407 ALG1 http://www.ncbi.nlm.nih.gov/gene/?term=852407 YBR110W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024356 852407 ALG1 http://www.ncbi.nlm.nih.gov/gene/?term=852407 YBR110W mRNA Saccharomyces cerevisiae 23904265 Endoplasmic reticulum Yeast Confocal microscopy "We examined mRNA localization by confocal microscopy and found that 9 of 11 mSMPs tagged (ALG1, GOS1, ICE2, PEP12, PMT2, SUC2, SUR4, USE1, and YIP3) showed high levels of granule colocalization with ER (>70%; Figure 1 and Table 1), and 2 (NYV1 and SEC22) showed lower levels of ER localization (56%; Figure 1 and Table 1). A similar low level of ER localization was observed with two mRNAs that encode soluble SNAREs (SEC9 and SEC20) known to associate with the plasma and ER membranes (Figure 1 and Table 1). Of interest, some preference toward nER localization was observed with mSMPs such as PMT2, SUC2, SUR4, USE1, and YIP3, whereas in contrast, most of the mRNAs encoding SNAREs (e.g., GOS1, NYV1, PEP12, SEC9, and SEC22) demonstrated a preference for cER (Table 1). Data are collected from Table 1. " RLID00024357 852429 AGP2 http://www.ncbi.nlm.nih.gov/gene/?term=852429 YBR132C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024358 852436 YBR139W http://www.ncbi.nlm.nih.gov/gene/?term=852436 YBR139W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024359 852456 IFA38 http://www.ncbi.nlm.nih.gov/gene/?term=852456 YBR159W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024360 852463 UBS1 http://www.ncbi.nlm.nih.gov/gene/?term=852463 YBR165W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024361 852482 YBR184W http://www.ncbi.nlm.nih.gov/gene/?term=852482 YBR184W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024362 852498 KTR4 http://www.ncbi.nlm.nih.gov/gene/?term=852498 YBR199W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024363 852504 KTR3 http://www.ncbi.nlm.nih.gov/gene/?term=852504 YBR205W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024364 852506 FTH1 http://www.ncbi.nlm.nih.gov/gene/?term=852506 YBR207W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024365 852521 YBR220C http://www.ncbi.nlm.nih.gov/gene/?term=852521 YBR220C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024366 852522 PDB1 http://www.ncbi.nlm.nih.gov/gene/?term=852522 YBR221C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024367 852523 PCS60 http://www.ncbi.nlm.nih.gov/gene/?term=852523 "YBR222C, FAT2 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024368 852523 PCS60 http://www.ncbi.nlm.nih.gov/gene/?term=852523 "YBR222C, FAT2 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024369 852543 YBR241C http://www.ncbi.nlm.nih.gov/gene/?term=852543 YBR241C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024370 852565 SHM1 http://www.ncbi.nlm.nih.gov/gene/?term=852565 "YBR263W, SHMT1, TMP3 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024371 852583 SAF1 http://www.ncbi.nlm.nih.gov/gene/?term=852583 YBR280C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024372 852586 SSH1 http://www.ncbi.nlm.nih.gov/gene/?term=852586 YBR283C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024373 852589 APE3 http://www.ncbi.nlm.nih.gov/gene/?term=852589 "YBR286W, APY1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024374 852590 YBR287W http://www.ncbi.nlm.nih.gov/gene/?term=852590 YBR287W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024375 852599 PHO89 http://www.ncbi.nlm.nih.gov/gene/?term=852599 "YBR296C, ITN1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024376 8525 DGKZ http://www.ncbi.nlm.nih.gov/gene/?term=8525 "DAGK5, DAGK6, DGK-ZETA, hDGKzeta " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024377 8525 DGKZ http://www.ncbi.nlm.nih.gov/gene/?term=8525 "DAGK5, DAGK6, DGK-ZETA, hDGKzeta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024378 852623 SHE10 http://www.ncbi.nlm.nih.gov/gene/?term=852623 YGL228W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024379 852637 ZRT1 http://www.ncbi.nlm.nih.gov/gene/?term=852637 YGL255W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024380 852654 MDM34 http://www.ncbi.nlm.nih.gov/gene/?term=852654 "YGL219C, MMM2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024381 852667 POX1 http://www.ncbi.nlm.nih.gov/gene/?term=852667 "YGL205W, FOX1 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024382 852667 POX1 http://www.ncbi.nlm.nih.gov/gene/?term=852667 "YGL205W, FOX1 " mRNA Saccharomyces cerevisiae 19903887 Mitochondrion Yeast RT-PCR "We next examined the localization of POX1 mRNA in cells expressing Oxa1-RFP, a mitochondrial marker, and found that 44% of POX1 granules colocalized with mitochondria (Table S4). In contrast, 82% of OXA1 mRNA granules [which localize to mitochondria (13, 14)] colocalized with Oxa1-RFP. The large number of cells having POX1 mRNA localized to mitochondria might stem from the fact that Oxa1-RFP-labeled mitochondria fill a substantial volume of the cell. " RLID00024383 852667 POX1 http://www.ncbi.nlm.nih.gov/gene/?term=852667 "YGL205W, FOX1 " mRNA Saccharomyces cerevisiae 19903887 Endoplasmic reticulum Yeast RT-PCR "To further analyze the specificity of mPP targeting, we examined the localization of the POX1 and GPD1 mRNAs in cells expressing Sec63-RFP (Fig. S1 B and C and Table S3). Interestingly, a high percentage of both RNAs colocalized with Sec63-RFP (59% and 71%, respectively; Table S3 and Fig. S1B and C). While mRNA localization to the ER could be due to the fact that ER fills much of the cell volume (see, e.g., Fig. S1B and C), we also demonstrated that peroxisomes decorate both nuclear and cortical ER (Fig. S1D). Thus, discerning whether mPP localization to the ER results from a direct association with ER membranes or is a consequence of binding to ER-associated peroxisomes is difficult. Alternatively, GPD1 mRNA, which encodes a glycerol-3-phosphate dehydrogenase found in the cytosol and peroxisomes, may preferentially localize to ER-like mRNAs encoding cytoplasmic proteins (13). This could allow for protein distribution to either compartment. Data are collected from Table S3: Localization of mPPs to ER. " RLID00024384 852667 POX1 http://www.ncbi.nlm.nih.gov/gene/?term=852667 "YGL205W, FOX1 " mRNA Saccharomyces cerevisiae 19903887 Cell cortex Yeast RT-PCR "To further analyze the specificity of mPP targeting, we examined the localization of the POX1 and GPD1 mRNAs in cells expressing Sec63-RFP (Fig. S1 B and C and Table S3). Interestingly, a high percentage of both RNAs colocalized with Sec63-RFP (59% and 71%, respectively; Table S3 and Fig. S1B and C). While mRNA localization to the ER could be due to the fact that ER fills much of the cell volume (see, e.g., Fig. S1B and C), we also demonstrated that peroxisomes decorate both nuclear and cortical ER (Fig. S1D). Thus, discerning whether mPP localization to the ER results from a direct association with ER membranes or is a consequence of binding to ER-associated peroxisomes is difficult. Alternatively, GPD1 mRNA, which encodes a glycerol-3-phosphate dehydrogenase found in the cytosol and peroxisomes, may preferentially localize to ER-like mRNAs encoding cytoplasmic proteins (13). This could allow for protein distribution to either compartment. Data are collected from Table S3: Localization of mPPs to ER. " RLID00024385 852667 POX1 http://www.ncbi.nlm.nih.gov/gene/?term=852667 "YGL205W, FOX1 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024386 852670 KEX1 http://www.ncbi.nlm.nih.gov/gene/?term=852670 YGL203C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024387 852675 EMP24 http://www.ncbi.nlm.nih.gov/gene/?term=852675 "YGL200C, BST2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024388 8526 DGKE http://www.ncbi.nlm.nih.gov/gene/?term=8526 "AHUS7, DAGK5, DAGK6, DGK, NPHS7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024389 852708 HUR1 http://www.ncbi.nlm.nih.gov/gene/?term=852708 YGL168W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024390 852709 PMR1 http://www.ncbi.nlm.nih.gov/gene/?term=852709 "YGL167C, BSD1, LDB1, SSC1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024391 852716 AIM14 http://www.ncbi.nlm.nih.gov/gene/?term=852716 "YGL160W, YNO1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024392 852724 PEX14 http://www.ncbi.nlm.nih.gov/gene/?term=852724 YGL153W mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024393 852724 PEX14 http://www.ncbi.nlm.nih.gov/gene/?term=852724 YGL153W mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024394 852738 FLC3 http://www.ncbi.nlm.nih.gov/gene/?term=852738 YGL139W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024395 852764 YGL114W http://www.ncbi.nlm.nih.gov/gene/?term=852764 YGL114W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024396 852775 RPL28 http://www.ncbi.nlm.nih.gov/gene/?term=852775 "YGL103W, CYH2 " mRNA Saccharomyces cerevisiae 8405926 Ribosome Yeast Northern blot "Fig. 1. Segregation of secretory protein mRNA to membrane- bound ribosomes. Northern blot analysis with CYH2, PRC1 and PH05. DNA fragments from the genes CYH2, PRC1 and PH05 hybridized to a Northern blot of 1 ug poly(A)+-RNA from membrane-bound (MBP) and free polysomes (FP). Data are collected from Figure 1. " RLID00024397 852780 USE1 http://www.ncbi.nlm.nih.gov/gene/?term=852780 "YGL098W, SLT1 " mRNA Saccharomyces cerevisiae 21705432 Nucleus Yeast Microarray|RT-PCR "We found that the USE1 and YIP3 mRNAs localized primarily with ER peripheral to the nucleus (nuclear ER; nER) (i.e., 52% colocalization with nER and 26% colocalization with cER for USE1 [78% ER total]; and 40% colocalization with nER and 29% colocalization with cER for YIP3 [69% ER total]) (data not shown), but exhibited only low levels of colocalization with mitochondria (e.g., 28% and 32%) (Table 1). " RLID00024398 852780 USE1 http://www.ncbi.nlm.nih.gov/gene/?term=852780 "YGL098W, SLT1 " mRNA Saccharomyces cerevisiae 21705432 Cell cortex Yeast Microarray|RT-PCR "We found that the USE1 and YIP3 mRNAs localized primarily with ER peripheral to the nucleus (nuclear ER; nER) (i.e., 52% colocalization with nER and 26% colocalization with cER for USE1 [78% ER total]; and 40% colocalization with nER and 29% colocalization with cER for YIP3 [69% ER total]) (data not shown), but exhibited only low levels of colocalization with mitochondria (e.g., 28% and 32%) (Table 1). " RLID00024399 852780 USE1 http://www.ncbi.nlm.nih.gov/gene/?term=852780 "YGL098W, SLT1 " mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024400 852780 USE1 http://www.ncbi.nlm.nih.gov/gene/?term=852780 "YGL098W, SLT1 " mRNA Saccharomyces cerevisiae 23904265 Endoplasmic reticulum Yeast Confocal microscopy "We examined mRNA localization by confocal microscopy and found that 9 of 11 mSMPs tagged (ALG1, GOS1, ICE2, PEP12, PMT2, SUC2, SUR4, USE1, and YIP3) showed high levels of granule colocalization with ER (>70%; Figure 1 and Table 1), and 2 (NYV1 and SEC22) showed lower levels of ER localization (56%; Figure 1 and Table 1). A similar low level of ER localization was observed with two mRNAs that encode soluble SNAREs (SEC9 and SEC20) known to associate with the plasma and ER membranes (Figure 1 and Table 1). Of interest, some preference toward nER localization was observed with mSMPs such as PMT2, SUC2, SUR4, USE1, and YIP3, whereas in contrast, most of the mRNAs encoding SNAREs (e.g., GOS1, NYV1, PEP12, SEC9, and SEC22) demonstrated a preference for cER (Table 1). Data are collected from Table 1. " RLID00024401 8527 DGKD http://www.ncbi.nlm.nih.gov/gene/?term=8527 "DGKdelta, dgkd-2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024402 8527 DGKD http://www.ncbi.nlm.nih.gov/gene/?term=8527 "DGKdelta, dgkd-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024403 852813 NPY1 http://www.ncbi.nlm.nih.gov/gene/?term=852813 YGL067W mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024404 852813 NPY1 http://www.ncbi.nlm.nih.gov/gene/?term=852813 YGL067W mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024405 852825 OLE1 http://www.ncbi.nlm.nih.gov/gene/?term=852825 "YGL055W, MDM2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024406 852830 MST27 http://www.ncbi.nlm.nih.gov/gene/?term=852830 YGL051W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024407 852844 YGL039W http://www.ncbi.nlm.nih.gov/gene/?term=852844 YGL039W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024408 852857 CWH41 http://www.ncbi.nlm.nih.gov/gene/?term=852857 "YGL027C, DER7, GLS1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024409 852862 STT3 http://www.ncbi.nlm.nih.gov/gene/?term=852862 YGL022W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024410 852872 ERG4 http://www.ncbi.nlm.nih.gov/gene/?term=852872 YGL012W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024411 852874 MPO1 http://www.ncbi.nlm.nih.gov/gene/?term=852874 YGL010W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024412 852876 PMA1 http://www.ncbi.nlm.nih.gov/gene/?term=852876 "YGL008C, KTI10 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024413 852892 SEC9 http://www.ncbi.nlm.nih.gov/gene/?term=852892 "YGR009C, HSS7 " mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024414 852892 SEC9 http://www.ncbi.nlm.nih.gov/gene/?term=852892 "YGR009C, HSS7 " mRNA Saccharomyces cerevisiae 23904265 Endoplasmic reticulum Yeast Confocal microscopy "We examined mRNA localization by confocal microscopy and found that 9 of 11 mSMPs tagged (ALG1, GOS1, ICE2, PEP12, PMT2, SUC2, SUR4, USE1, and YIP3) showed high levels of granule colocalization with ER (>70%; Figure 1 and Table 1), and 2 (NYV1 and SEC22) showed lower levels of ER localization (56%; Figure 1 and Table 1). A similar low level of ER localization was observed with two mRNAs that encode soluble SNAREs (SEC9 and SEC20) known to associate with the plasma and ER membranes (Figure 1 and Table 1). Of interest, some preference toward nER localization was observed with mSMPs such as PMT2, SUC2, SUR4, USE1, and YIP3, whereas in contrast, most of the mRNAs encoding SNAREs (e.g., GOS1, NYV1, PEP12, SEC9, and SEC22) demonstrated a preference for cER (Table 1). Data are collected from Table 1. " RLID00024415 852905 MTL1 http://www.ncbi.nlm.nih.gov/gene/?term=852905 YGR023W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024416 852905 MTL1 http://www.ncbi.nlm.nih.gov/gene/?term=852905 YGR023W mRNA Saccharomyces cerevisiae 18805955 Cellular bud Yeast qRT-PCR "Khd1p colocalizes with a subset of mRNAs at the bud-tip of yeast cells.The U1A-GFP-tagged RNAs for ASH1, MID2, MTL1, and WSC2 colocalized with Khd1p, whereas BRO1 and TPO3 mRNAs did not colocalize. " RLID00024417 852910 YGR026W http://www.ncbi.nlm.nih.gov/gene/?term=852910 YGR026W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024418 852919 IMO32 http://www.ncbi.nlm.nih.gov/gene/?term=852919 YGR031W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024419 852920 GSC2 http://www.ncbi.nlm.nih.gov/gene/?term=852920 "YGR032W, FKS2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024420 852921 TIM21 http://www.ncbi.nlm.nih.gov/gene/?term=852921 YGR033C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024421 852937 TAM41 http://www.ncbi.nlm.nih.gov/gene/?term=852937 "YGR046W, MMP37 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024422 852946 MUP1 http://www.ncbi.nlm.nih.gov/gene/?term=852946 YGR055W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024423 852968 PEX8 http://www.ncbi.nlm.nih.gov/gene/?term=852968 "YGR077C, PAS6 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024424 852968 PEX8 http://www.ncbi.nlm.nih.gov/gene/?term=852968 "YGR077C, PAS6 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024425 852980 NNF2 http://www.ncbi.nlm.nih.gov/gene/?term=852980 YGR089W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024426 852998 VOA1 http://www.ncbi.nlm.nih.gov/gene/?term=852998 YGR106C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024427 853009 SHY1 http://www.ncbi.nlm.nih.gov/gene/?term=853009 YGR112W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024428 853019 MEP1 http://www.ncbi.nlm.nih.gov/gene/?term=853019 "YGR121C, AMT1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024429 853026 YGR125W http://www.ncbi.nlm.nih.gov/gene/?term=853026 YGR125W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024430 853039 TPO2 http://www.ncbi.nlm.nih.gov/gene/?term=853039 YGR138C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024431 853042 VPS62 http://www.ncbi.nlm.nih.gov/gene/?term=853042 YGR141W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024432 853045 SKN1 http://www.ncbi.nlm.nih.gov/gene/?term=853045 YGR143W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024433 853050 NAT2 http://www.ncbi.nlm.nih.gov/gene/?term=853050 YGR147C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024434 853052 YGR149W http://www.ncbi.nlm.nih.gov/gene/?term=853052 YGR149W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024435 853053 CCM1 http://www.ncbi.nlm.nih.gov/gene/?term=853053 "YGR150C, DMR1, RRG2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024436 853061 CHO2 http://www.ncbi.nlm.nih.gov/gene/?term=853061 "YGR157W, PEM1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024437 85308 Emc9 http://www.ncbi.nlm.nih.gov/gene/?term=85308 "1500005A01Rik, Cgi112, Fam158a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00024438 853102 CRH1 http://www.ncbi.nlm.nih.gov/gene/?term=853102 YGR189C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024439 853104 HIP1 http://www.ncbi.nlm.nih.gov/gene/?term=853104 YGR191W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024440 853111 SNG1 http://www.ncbi.nlm.nih.gov/gene/?term=853111 YGR197C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024441 853139 AZR1 http://www.ncbi.nlm.nih.gov/gene/?term=853139 YGR224W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024442 853146 PHB2 http://www.ncbi.nlm.nih.gov/gene/?term=853146 YGR231C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024443 853151 SPG1 http://www.ncbi.nlm.nih.gov/gene/?term=853151 YGR236C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024444 853153 KEL2 http://www.ncbi.nlm.nih.gov/gene/?term=853153 YGR238C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024445 853154 PEX21 http://www.ncbi.nlm.nih.gov/gene/?term=853154 YGR239C mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024446 853159 LSC2 http://www.ncbi.nlm.nih.gov/gene/?term=853159 YGR244C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024447 853159 LSC2 http://www.ncbi.nlm.nih.gov/gene/?term=853159 YGR244C mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024448 85315 PAQR8 http://www.ncbi.nlm.nih.gov/gene/?term=85315 "C6orf33, LMPB1, MPRB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024449 85315 PAQR8 http://www.ncbi.nlm.nih.gov/gene/?term=85315 "C6orf33, LMPB1, MPRB " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024450 85315 PAQR8 http://www.ncbi.nlm.nih.gov/gene/?term=85315 "C6orf33, LMPB1, MPRB " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024451 853196 SCW4 http://www.ncbi.nlm.nih.gov/gene/?term=853196 YGR279C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024452 853198 YOR1 http://www.ncbi.nlm.nih.gov/gene/?term=853198 "YGR281W, YRS1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024453 853199 BGL2 http://www.ncbi.nlm.nih.gov/gene/?term=853199 "YGR282C, SCW9 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024454 8531 YBX3 http://www.ncbi.nlm.nih.gov/gene/?term=8531 "CSDA, CSDA1, DBPA, ZONAB " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024455 8531 YBX3 http://www.ncbi.nlm.nih.gov/gene/?term=8531 "CSDA, CSDA1, DBPA, ZONAB " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024456 8531 YBX3 http://www.ncbi.nlm.nih.gov/gene/?term=8531 "CSDA, CSDA1, DBPA, ZONAB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024457 853201 ERV29 http://www.ncbi.nlm.nih.gov/gene/?term=853201 YGR284C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024458 853203 BIO2 http://www.ncbi.nlm.nih.gov/gene/?term=853203 YGR286C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024459 853212 COS6 http://www.ncbi.nlm.nih.gov/gene/?term=853212 YGR295C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024460 853213 YRF1-3 http://www.ncbi.nlm.nih.gov/gene/?term=853213 "YGR296W, YRF1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024461 853216 HXT8 http://www.ncbi.nlm.nih.gov/gene/?term=853216 YJL214W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024462 853231 YJL225C http://www.ncbi.nlm.nih.gov/gene/?term=853231 YJL225C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024463 853233 VTH2 http://www.ncbi.nlm.nih.gov/gene/?term=853233 YJL222W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024464 853236 HXT9 http://www.ncbi.nlm.nih.gov/gene/?term=853236 YJL219W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024465 853265 KRE9 http://www.ncbi.nlm.nih.gov/gene/?term=853265 YJL174W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024466 853267 CPS1 http://www.ncbi.nlm.nih.gov/gene/?term=853267 YJL172W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024467 853276 YJL163C http://www.ncbi.nlm.nih.gov/gene/?term=853276 YJL163C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024468 853280 PIR5 http://www.ncbi.nlm.nih.gov/gene/?term=853280 YJL160C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024469 853281 HSP150 http://www.ncbi.nlm.nih.gov/gene/?term=853281 "YJL159W, CCW7, ORE1, PIR2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024470 853282 CIS3 http://www.ncbi.nlm.nih.gov/gene/?term=853282 "YJL158C, CCW11, CCW5, PIR4, SCW8 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024471 853297 YJL144W http://www.ncbi.nlm.nih.gov/gene/?term=853297 YJL144W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024472 8532 CPZ http://www.ncbi.nlm.nih.gov/gene/?term=8532 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024473 853304 GLG2 http://www.ncbi.nlm.nih.gov/gene/?term=853304 YJL137C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024474 853307 LCB3 http://www.ncbi.nlm.nih.gov/gene/?term=853307 "YJL134W, LBP1, YSR2 " mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024475 853325 PHO86 http://www.ncbi.nlm.nih.gov/gene/?term=853325 YJL117W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024476 853356 SIP4 http://www.ncbi.nlm.nih.gov/gene/?term=853356 YJL089W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024477 853357 ARG3 http://www.ncbi.nlm.nih.gov/gene/?term=853357 YJL088W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024478 853366 PRY1 http://www.ncbi.nlm.nih.gov/gene/?term=853366 YJL079C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024479 853392 TIM54 http://www.ncbi.nlm.nih.gov/gene/?term=853392 YJL054W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024480 8533 COPS3 http://www.ncbi.nlm.nih.gov/gene/?term=8533 "CSN3, SGN3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024481 8533 COPS3 http://www.ncbi.nlm.nih.gov/gene/?term=8533 "CSN3, SGN3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024482 8533 COPS3 http://www.ncbi.nlm.nih.gov/gene/?term=8533 "CSN3, SGN3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024483 853405 YJL045W http://www.ncbi.nlm.nih.gov/gene/?term=853405 YJL045W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024484 853418 KAR2 http://www.ncbi.nlm.nih.gov/gene/?term=853418 "YJL034W, GRP78 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024485 853455 OST1 http://www.ncbi.nlm.nih.gov/gene/?term=853455 "YJL002C, NLT1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024486 853464 MHO1 http://www.ncbi.nlm.nih.gov/gene/?term=853464 YJR008W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024487 853472 YJR015W http://www.ncbi.nlm.nih.gov/gene/?term=853472 YJR015W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024488 853473 ILV3 http://www.ncbi.nlm.nih.gov/gene/?term=853473 YJR016C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024489 8534 CHST1 http://www.ncbi.nlm.nih.gov/gene/?term=8534 "C6ST, GST-1, KS6ST, KSGal6ST, KSST " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024490 853503 SSC1 http://www.ncbi.nlm.nih.gov/gene/?term=853503 "YJR045C, ENS1 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024491 853503 SSC1 http://www.ncbi.nlm.nih.gov/gene/?term=853503 "YJR045C, ENS1 " mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR TABLE 1: Localization of mRNAs encoding mitochondrial proteins in yeast. Data are collected from Table 1. RLID00024492 853510 OSM1 http://www.ncbi.nlm.nih.gov/gene/?term=853510 YJR051W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024493 853528 ARP3 http://www.ncbi.nlm.nih.gov/gene/?term=853528 "YJR065C, ACT4 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024494 853538 HOC1 http://www.ncbi.nlm.nih.gov/gene/?term=853538 YJR075W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024495 853540 MIR1 http://www.ncbi.nlm.nih.gov/gene/?term=853540 YJR077C mRNA Saccharomyces cerevisiae 11027259 Ribosome Yeast Northern blot "In contrast, mRNAs encoding Cox6p, Cox5a, Aac1p, and Mir1p are found enriched in free cytoplasmic polysome fractions. Transcripts coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p are exclusively localized to mitochondrion-bound polysomes, while mRNAs encoding Cox6p, Cox5ap, Aac1p, and Mir1p are enriched in free cytoplasmic polysomes. The third family mRNAs were those predominantly associated with free cytoplasmic polysomes (Fig. ?(Fig.1A,1A, lanes F-P), such as COX6, COX5a, AAC1, and MIR1. " RLID00024496 853543 AIM24 http://www.ncbi.nlm.nih.gov/gene/?term=853543 "YJR080C, FMP26 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024497 853581 STE24 http://www.ncbi.nlm.nih.gov/gene/?term=853581 "YJR117W, AFC1, PIO2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024498 853584 YJR120W http://www.ncbi.nlm.nih.gov/gene/?term=853584 YJR120W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024499 853585 ATP2 http://www.ncbi.nlm.nih.gov/gene/?term=853585 YJR121W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024500 853585 ATP2 http://www.ncbi.nlm.nih.gov/gene/?term=853585 YJR121W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024501 853585 ATP2 http://www.ncbi.nlm.nih.gov/gene/?term=853585 YJR121W mRNA Saccharomyces cerevisiae 11027259 Ribosome Yeast Northern blot "Some mRNAs exclusively localize to mitochondrion-bound polysomes, such as the ones coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p. Transcripts coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p are exclusively localized to mitochondrion-bound polysomes, while mRNAs encoding Cox6p, Cox5ap, Aac1p, and Mir1p are enriched in free cytoplasmic polysomes. The first family includes mRNAs exclusively localized to polysomes bound to mitochondria (Fig. ?(Fig.1A,1A, lanes M-P), such as ATM1, COX10, TIM44, ATP2, and COT1 mRNAs. " RLID00024502 853585 ATP2 http://www.ncbi.nlm.nih.gov/gene/?term=853585 YJR121W mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR TABLE 1: Localization of mRNAs encoding mitochondrial proteins in yeast. Data are collected from Table 1. RLID00024503 853585 ATP2 http://www.ncbi.nlm.nih.gov/gene/?term=853585 YJR121W mRNA Saccharomyces cerevisiae 21705432 Endoplasmic reticulum Yeast Microarray|RT-PCR TABLE 2. OXA1 and ATP2 mRNA localization to mitochondria and ER. RLID00024504 85359 DGCR6L http://www.ncbi.nlm.nih.gov/gene/?term=85359 DGCR6 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024505 85359 DGCR6L http://www.ncbi.nlm.nih.gov/gene/?term=85359 DGCR6 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024506 8535 CBX4 http://www.ncbi.nlm.nih.gov/gene/?term=8535 "NBP16, PC2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024507 853607 YJR142W http://www.ncbi.nlm.nih.gov/gene/?term=853607 YJR142W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024508 853636 PEX1 http://www.ncbi.nlm.nih.gov/gene/?term=853636 "YKL197C, PAS1 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024509 853636 PEX1 http://www.ncbi.nlm.nih.gov/gene/?term=853636 "YKL197C, PAS1 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024510 853638 YKT6 http://www.ncbi.nlm.nih.gov/gene/?term=853638 YKL196C mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024511 853639 MIA40 http://www.ncbi.nlm.nih.gov/gene/?term=853639 "YKL195W, FMP15, TIM40 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024512 853639 MIA40 http://www.ncbi.nlm.nih.gov/gene/?term=853639 "YKL195W, FMP15, TIM40 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024513 85363 TRIM5 http://www.ncbi.nlm.nih.gov/gene/?term=85363 "RNF88alpha, TRIM5 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024514 85363 TRIM5 http://www.ncbi.nlm.nih.gov/gene/?term=85363 "RNF88alpha, TRIM5 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024515 853647 PXA2 http://www.ncbi.nlm.nih.gov/gene/?term=853647 "YKL188C, PAT1 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024516 85364 ZCCHC3 http://www.ncbi.nlm.nih.gov/gene/?term=85364 C20orf99 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024517 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 9809065 Cellular bud Yeast In situ hybridization "ASH1 mRNA localizes to the bud tip in Saccharomyces cerevisiae to establish asymmetry of HO expression, important for mating type switching. " RLID00024518 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 12504008 Cellular bud Yeast In situ hybridization "ASH1 mRNA localizes at the bud tip of late-anaphase yeast, resulting in accumulation of Ash1p in the daughter nucleus. " RLID00024519 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 14662358 Cellular bud Yeast Fluorescence in situ hybridization Active transport and localized translation of the ASH1 mRNA at the bud tip of the budding yeast Saccharomyces cerevisiae is an essential process that is required for the regulation of the mating type switching. RLID00024520 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 14691136 Cellular bud Yeast In situ hybridization "We found that IST2 mRNA localized to the bud tip in wild-type cells and in an aux1Δ mutant, lacking the entire AUX1 gene (Fig. 8 A). Similar results were obtained when the localization of ASH1 mRNA was examined (not depicted). " RLID00024521 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 15328357 Cellular bud Yeast In situ hybridization "In Saccharomyces cerevisiae, the localization of ASH1 mRNA to the distal tip of budding cells results in the asymmetric sorting of Ash1p to daughter cell nuclei. " RLID00024522 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 15356266 Cellular bud Yeast Fluorescence in situ hybridization "Figure 6. Arf1p and Pab1p are required for ASH1 mRNA localization to the bud tip. In the wild-type strain, >60% of cells showed the correct localization of ASH1 mRNA in the bud tip at 30 and 16°C. Our results indicate that restricting ASH1 mRNA to the bud tip requires functional ER-Golgi transport. " RLID00024523 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 15601259 Cellular bud Yeast In situ hybridization Figure 1: Intracellular distribution of ASH1 mRNA DNA oligonucleotide probes (red) complementary to ASH1 mRNA were used for in situ hybridization (left-hand panel). ASH1 mRNA is localized at distal tip of anaphase cells. Also shown (right-hand panel) is the corresponding DAPI (blue)/Nomarski merged image. RLID00024524 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 15852043 Cellular bud Yeast - "The best understood example of active transport of mRNA is the localization of ASH1 mRNA to the bud tip in S. cerevisiae, which results in the repression of MATING TYPE SWITCHING in the daughter cell (FIG. 1a,b). " RLID00024525 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 16890529 Ribosome She2 cell Fluorescence in situ hybridization "Here, a genome-wide analysis of translated mRNAs demonstrated that ASH1 is mainly translated on ER bound polysomes. " RLID00024526 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization "As SEC4 mRNA is asymmetrically distributed to the bud prior to nuclear division, similar to ASH1 mRNA, we examined the localization of other POL mRNAs by FISH (Fig. (Fig.1B).1B). " RLID00024527 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 17339339 Endoplasmic reticulum Yeast RT-PCR "Importantly, mRNAs encoding Sec4, Cdc42, Sro7, and Snc1 were specifically enriched in the ER fraction, along with ASH1 mRNA (Fig. 9B), which was shown to be enriched on the ER (18). mRNAs encoding RDN18, a ribosomal rRNA, and TUB1 were found in both the ER and cytosolic fractions (Fig. 9B). " RLID00024528 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 17588515 Cellular bud Yeast Fluorescence in situ hybridization "To determine if this defective sorting of Ash1p was caused by a decreased localization of the ASH1 mRNA at the bud tip in a khd1 strain, the localization of this transcript was assessed by FISH. " RLID00024529 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 18413716 Cell cortex Yeast qRT-PCR "In the wild-type strain, 80% of ASH1 mRNA was localized at the distal cortex of the bud. However, in the fun12 mutant, ASH1 mRNA was localized diffusely within the bud (62%), in the neck (16%), or in the mother and bud (12%) (Fig. 2G) " RLID00024530 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 18805955 Cellular bud Yeast qRT-PCR "Khd1p associates with a subset of bud-tip-localized mRNAs. ASH1, MID2, and MTL1 mRNAs, but not BRO1 mRNA, were detected by RT-PCR in RNAs isolated from total extracts (Input) and from Khd1p-TAP affinity isolations (Khd1p).overexpression inhibits ASH1 expression (Irie et al. 2002). Therefore, we systematically examined whether Khd1p modifies protein expression of other bud-tip-localized mRNAs that are bound by Khd1p (MID2, MTL1, WSC2, SRL1, EGT2, and CLB2). " RLID00024531 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 19244342 Cellular bud Yeast Fluorescence in situ hybridization "In yeast, the nucleocytoplasmic shuttling protein She2 binds the ASH1 mRNA and targets it for localization at the bud tip by recruiting the She3p-Myo4p complex. " RLID00024532 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 20457760 Cellular bud Yeast Fluorescence microscopy "Taken together, our data suggest that continuous transport of ASH1 mRNA to the bud tip is generated by recruiting multiple nonprocessive Myo4 motors to a localizatione element, possibly through interactions with the tetrameric She2. " RLID00024533 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 20713510 Cytoplasm Yeast Fluorescence in situ hybridization "Altogether, these results provide evidence that the cotranscriptional recruitment of She2p on the ASH1 gene via the Spt4-Spt5 elongation complex is important for cytoplasmic ASH1 mRNA localization. " RLID00024534 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 20713510 Cellular bud Yeast Chip-seq "In yeast, the RNA-binding protein She2p binds several mRNAs and targets them for localization at the bud. Here we report that She2p is recruited cotranscriptionally to the nascent bud-localized ASH1, IST2, and EAR1 mRNA. " RLID00024535 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 21705432 Cellular bud Yeast Microarray|RT-PCR "We found that tagged ASH1 and MYO2 mRNAs both localized to the bud tip and showed only a very low level of colocalization with mitochondria (e.g., 18% and 12%, respectively) (Table 1). " RLID00024536 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 22994588 Endoplasmic reticulum Yeast qRT-PCR Figure 1. Distribution of endogenous ASH1 mRNA is not impaired in a mutant that affects cER segregation. Figure S5. Localization of MS2-tagged ASH1 mRNA in ER segregation or morphology mutants. RLID00024537 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 22994588 Cellular bud Yeast Microscopy "Together with our previous observation that aux1 cells properly localize ASH1 mRNA, this indicates that ASH1 mRNA is transported to the bud tip independently of ER. Intriguingly, as has been described before, loss of Sec3p increases the number of mislocalizedASH1 mRNP particles, which suggests that Sec3p might have a more direct role in RNA localization at the bud tip (see Discussion). " RLID00024538 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 24056370 Cellular bud Yeast - "In budding yeast, mRNA localization has been studied mainly using ASH1 mRNA as a model RNA. ASH1 encodes a transcriptional repressor and cell fate determinant and is localized to the tip of the mature bud (the daughter cell).Besides ASH1, more than 30 additional mRNAs are localized in a Myo4p- and She2p-dependent way to the bud tip. " RLID00024539 853650 ASH1 http://www.ncbi.nlm.nih.gov/gene/?term=853650 YKL185W mRNA Saccharomyces cerevisiae 10359695 Cellular bud Yeast Fluorescence in situ hybridization Our live-cell studies reveal that ASH1 mRNA is anchored to cortical sites near the bud tip in vegetative cells as well as near the mating projection during karyogamy (fusion of haploid nuclei upon mating). RLID00024540 85365 ALG2 http://www.ncbi.nlm.nih.gov/gene/?term=85365 "CDGIi, CMS14, CMSTA3, NET38, hALPG2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024541 85365 ALG2 http://www.ncbi.nlm.nih.gov/gene/?term=85365 "CDGIi, CMS14, CMSTA3, NET38, hALPG2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024542 853663 JEN1 http://www.ncbi.nlm.nih.gov/gene/?term=853663 YKL217W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024543 853677 STE3 http://www.ncbi.nlm.nih.gov/gene/?term=853677 "YKL178C, DAF2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024544 853679 ZRT3 http://www.ncbi.nlm.nih.gov/gene/?term=853679 YKL175W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024545 853692 PIR1 http://www.ncbi.nlm.nih.gov/gene/?term=853692 "YKL164C, CCW6 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024546 853693 PIR3 http://www.ncbi.nlm.nih.gov/gene/?term=853693 "YKL163W, CCW8 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024547 85369 STRIP1 http://www.ncbi.nlm.nih.gov/gene/?term=85369 "FAM40A, FAR11A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024548 8536 CAMK1 http://www.ncbi.nlm.nih.gov/gene/?term=8536 CAMKI mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024549 8536 CAMK1 http://www.ncbi.nlm.nih.gov/gene/?term=8536 CAMKI mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024550 8536 CAMK1 http://www.ncbi.nlm.nih.gov/gene/?term=8536 CAMKI mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024551 853706 YKL151C http://www.ncbi.nlm.nih.gov/gene/?term=853706 YKL151C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024552 853707 MCR1 http://www.ncbi.nlm.nih.gov/gene/?term=853707 YKL150W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024553 853707 MCR1 http://www.ncbi.nlm.nih.gov/gene/?term=853707 YKL150W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024554 853709 SDH1 http://www.ncbi.nlm.nih.gov/gene/?term=853709 YKL148C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024555 853709 SDH1 http://www.ncbi.nlm.nih.gov/gene/?term=853709 YKL148C mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024556 853710 AVT3 http://www.ncbi.nlm.nih.gov/gene/?term=853710 YKL146W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024557 853716 SDH3 http://www.ncbi.nlm.nih.gov/gene/?term=853716 "YKL141W, CYB3, YKL4 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024558 853725 YKL133C http://www.ncbi.nlm.nih.gov/gene/?term=853725 YKL133C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024559 853728 SHE2 http://www.ncbi.nlm.nih.gov/gene/?term=853728 YKL130C mRNA Saccharomyces cerevisiae 24056370 Endoplasmic reticulum Yeast Binding assay "FIGURE 3: Recombinant She2p binds to ER microsomes but not to mitochondria. A, pelleting of purified microsomes with recombinant She2p and GST. She2p or GST were mixed with ER membranes or buffer before centrifugation through a 1.2 m sucrose cushion. Equivalent amounts of the pellet (Pel), supernatant (Sup), or input material were analyzed by Western blotting against She2p, GST, or Sec61p. She2p is detectable in the pellet only in the presence of membranes. Spurious amounts of GST can be seen in the pellet fraction. B, the indicated amounts of She2p were incubated with 40 μl of microsomes (corresponding to 40 μg of membrane-associated protein). Input and bound She2p were analyzed by quantitative Western blotting, and the ratio of bound She2p signal versus input was quantified. The mean ratio (in percent) and S.D. of three experiments is displayed. C, purified microsomes or yeast mitochondria were mixed with She2p and pelleted through a sucrose cushion. She2p copellets only with microsomes. Sec61p served as an ER marker, whereas Mcr1p indicated mitochondria. In the absence of membranes, She2p can only be detected in the supernatant. Inp, input. Data are collected from Figure 3. " RLID00024560 853747 RAD27 http://www.ncbi.nlm.nih.gov/gene/?term=853747 "YKL113C, ERC11, FEN1, RTH1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024561 853753 YKL107W http://www.ncbi.nlm.nih.gov/gene/?term=853753 YKL107W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024562 853763 MTC2 http://www.ncbi.nlm.nih.gov/gene/?term=853763 YKL098W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024563 853777 MDH1 http://www.ncbi.nlm.nih.gov/gene/?term=853777 YKL085W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024564 853777 MDH1 http://www.ncbi.nlm.nih.gov/gene/?term=853777 YKL085W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024565 85377 MICALL1 http://www.ncbi.nlm.nih.gov/gene/?term=85377 "MICAL-L1, MIRAB13 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024566 85377 MICALL1 http://www.ncbi.nlm.nih.gov/gene/?term=85377 "MICAL-L1, MIRAB13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024567 853780 RRP14 http://www.ncbi.nlm.nih.gov/gene/?term=853780 YKL082C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024568 853785 YKL077W http://www.ncbi.nlm.nih.gov/gene/?term=853785 YKL077W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024569 85379 KIAA1671 http://www.ncbi.nlm.nih.gov/gene/?term=85379 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024570 85379 KIAA1671 http://www.ncbi.nlm.nih.gov/gene/?term=85379 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024571 853801 MNR2 http://www.ncbi.nlm.nih.gov/gene/?term=853801 YKL064W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024572 853820 DCW1 http://www.ncbi.nlm.nih.gov/gene/?term=853820 YKL046C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024573 853832 TUL1 http://www.ncbi.nlm.nih.gov/gene/?term=853832 YKL034W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024574 853882 PRY2 http://www.ncbi.nlm.nih.gov/gene/?term=853882 "YKR013W, YFW12 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024575 85389 SNORD14C http://www.ncbi.nlm.nih.gov/gene/?term=85389 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00024576 853916 UTH1 http://www.ncbi.nlm.nih.gov/gene/?term=853916 YKR042W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024577 85391 SNORD14E http://www.ncbi.nlm.nih.gov/gene/?term=85391 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024578 85391 SNORD14E http://www.ncbi.nlm.nih.gov/gene/?term=85391 snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00024579 853940 CCP1 http://www.ncbi.nlm.nih.gov/gene/?term=853940 YKR066C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024580 853940 CCP1 http://www.ncbi.nlm.nih.gov/gene/?term=853940 YKR066C mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024581 85395 FAM207A http://www.ncbi.nlm.nih.gov/gene/?term=85395 "C21orf70, PRED56 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024582 85397 RGS8 http://www.ncbi.nlm.nih.gov/gene/?term=85397 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024583 853991 VPS68 http://www.ncbi.nlm.nih.gov/gene/?term=853991 YOL129W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024584 8539 API5 http://www.ncbi.nlm.nih.gov/gene/?term=8539 "AAC-11, AAC11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024585 8539 API5 http://www.ncbi.nlm.nih.gov/gene/?term=8539 "AAC-11, AAC11 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024586 8539 API5 http://www.ncbi.nlm.nih.gov/gene/?term=8539 "AAC-11, AAC11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024587 854009 HXT11 http://www.ncbi.nlm.nih.gov/gene/?term=854009 "YOL156W, LGT3 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024588 854018 PEX11 http://www.ncbi.nlm.nih.gov/gene/?term=854018 "YOL147C, PMP24, PMP27 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024589 854018 PEX11 http://www.ncbi.nlm.nih.gov/gene/?term=854018 "YOL147C, PMP24, PMP27 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024590 854030 MCH4 http://www.ncbi.nlm.nih.gov/gene/?term=854030 YOL119C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024591 85403 EAF1 http://www.ncbi.nlm.nih.gov/gene/?term=85403 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024592 854057 COQ3 http://www.ncbi.nlm.nih.gov/gene/?term=854057 YOL096C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024593 85406 DNAJC14 http://www.ncbi.nlm.nih.gov/gene/?term=85406 "DNAJ, DRIP78, HDJ3, LIP6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024594 85406 DNAJC14 http://www.ncbi.nlm.nih.gov/gene/?term=85406 "DNAJ, DRIP78, HDJ3, LIP6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024595 85406 DNAJC14 http://www.ncbi.nlm.nih.gov/gene/?term=85406 "DNAJ, DRIP78, HDJ3, LIP6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024596 85406 DNAJC14 http://www.ncbi.nlm.nih.gov/gene/?term=85406 "DNAJ, DRIP78, HDJ3, LIP6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024597 854070 PHM7 http://www.ncbi.nlm.nih.gov/gene/?term=854070 YOL084W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024598 854071 ATG34 http://www.ncbi.nlm.nih.gov/gene/?term=854071 YOL083W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024599 854081 DSC2 http://www.ncbi.nlm.nih.gov/gene/?term=854081 YOL073C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024600 8540 AGPS http://www.ncbi.nlm.nih.gov/gene/?term=8540 "ADAP-S, ADAS, ADHAPS, ADPS, ALDHPSY, RCDP3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024601 854109 RRT8 http://www.ncbi.nlm.nih.gov/gene/?term=854109 YOL048C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024602 854113 PEX15 http://www.ncbi.nlm.nih.gov/gene/?term=854113 "YOL044W, PAS21 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024603 854113 PEX15 http://www.ncbi.nlm.nih.gov/gene/?term=854113 "YOL044W, PAS21 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024604 854127 GAS5 http://www.ncbi.nlm.nih.gov/gene/?term=854127 YOL030W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024605 854130 MDM38 http://www.ncbi.nlm.nih.gov/gene/?term=854130 "YOL027C, MKH1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024606 854144 CMK2 http://www.ncbi.nlm.nih.gov/gene/?term=854144 YOL016C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024607 85414 SLC45A3 http://www.ncbi.nlm.nih.gov/gene/?term=85414 "IPCA-2, IPCA-6, IPCA-8, IPCA6, PCANAP2, PCANAP6, PCANAP8, PRST " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024608 85414 SLC45A3 http://www.ncbi.nlm.nih.gov/gene/?term=85414 "IPCA-2, IPCA-6, IPCA-8, IPCA6, PCANAP2, PCANAP6, PCANAP8, PRST " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024609 85415 RHPN2 http://www.ncbi.nlm.nih.gov/gene/?term=85415 "P76RBE, RHOBP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024610 85415 RHPN2 http://www.ncbi.nlm.nih.gov/gene/?term=85415 "P76RBE, RHOBP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024611 85415 RHPN2 http://www.ncbi.nlm.nih.gov/gene/?term=85415 "P76RBE, RHOBP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024612 85415 RHPN2 http://www.ncbi.nlm.nih.gov/gene/?term=85415 "P76RBE, RHOBP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024613 85415 RHPN2 http://www.ncbi.nlm.nih.gov/gene/?term=85415 "P76RBE, RHOBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024614 854170 SLG1 http://www.ncbi.nlm.nih.gov/gene/?term=854170 "YOR008C, HCS77, WSC1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024615 854188 AHC1 http://www.ncbi.nlm.nih.gov/gene/?term=854188 YOR023C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024616 8541 PPFIA3 http://www.ncbi.nlm.nih.gov/gene/?term=8541 LPNA3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024617 854201 PEP12 http://www.ncbi.nlm.nih.gov/gene/?term=854201 "YOR036W, VPL6, VPS6, VPT13 " mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024618 854201 PEP12 http://www.ncbi.nlm.nih.gov/gene/?term=854201 "YOR036W, VPL6, VPS6, VPT13 " mRNA Saccharomyces cerevisiae 23904265 Endoplasmic reticulum Yeast Confocal microscopy "We examined mRNA localization by confocal microscopy and found that 9 of 11 mSMPs tagged (ALG1, GOS1, ICE2, PEP12, PMT2, SUC2, SUR4, USE1, and YIP3) showed high levels of granule colocalization with ER (>70%; Figure 1 and Table 1), and 2 (NYV1 and SEC22) showed lower levels of ER localization (56%; Figure 1 and Table 1). A similar low level of ER localization was observed with two mRNAs that encode soluble SNAREs (SEC9 and SEC20) known to associate with the plasma and ER membranes (Figure 1 and Table 1). Of interest, some preference toward nER localization was observed with mSMPs such as PMT2, SUC2, SUR4, USE1, and YIP3, whereas in contrast, most of the mRNAs encoding SNAREs (e.g., GOS1, NYV1, PEP12, SEC9, and SEC22) demonstrated a preference for cER (Table 1). Data are collected from Table 1. " RLID00024619 854231 CYT1 http://www.ncbi.nlm.nih.gov/gene/?term=854231 "YOR065W, CTC1, YOR29-16 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024620 854266 KTR1 http://www.ncbi.nlm.nih.gov/gene/?term=854266 YOR099W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024621 854275 LEU9 http://www.ncbi.nlm.nih.gov/gene/?term=854275 YOR108W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024622 8542 APOL1 http://www.ncbi.nlm.nih.gov/gene/?term=8542 "APO-L, APOL, APOL-I, FSGS4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024623 8542 APOL1 http://www.ncbi.nlm.nih.gov/gene/?term=8542 "APO-L, APOL, APOL-I, FSGS4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024624 854303 IDH2 http://www.ncbi.nlm.nih.gov/gene/?term=854303 YOR136W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024625 854303 IDH2 http://www.ncbi.nlm.nih.gov/gene/?term=854303 YOR136W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024626 854310 LSC1 http://www.ncbi.nlm.nih.gov/gene/?term=854310 YOR142W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024627 854332 PNS1 http://www.ncbi.nlm.nih.gov/gene/?term=854332 YOR161C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024628 854352 DCI1 http://www.ncbi.nlm.nih.gov/gene/?term=854352 "YOR180C, ECI2 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024629 854352 DCI1 http://www.ncbi.nlm.nih.gov/gene/?term=854352 "YOR180C, ECI2 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024630 854359 TUF1 http://www.ncbi.nlm.nih.gov/gene/?term=854359 YOR187W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024631 854368 PEX27 http://www.ncbi.nlm.nih.gov/gene/?term=854368 YOR193W mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024632 854371 LIP5 http://www.ncbi.nlm.nih.gov/gene/?term=854371 YOR196C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024633 85437 ZCRB1 http://www.ncbi.nlm.nih.gov/gene/?term=85437 "MADP-1, MADP1, RBM36, SNRNP31, ZCCHC19 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024634 854386 MGM1 http://www.ncbi.nlm.nih.gov/gene/?term=854386 "YOR211C, MNA1 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024635 854396 MCT1 http://www.ncbi.nlm.nih.gov/gene/?term=854396 YOR221C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024636 85439 STON2 http://www.ncbi.nlm.nih.gov/gene/?term=85439 "STN2, STNB, STNB2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024637 8543 LMO4 http://www.ncbi.nlm.nih.gov/gene/?term=8543 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024638 854407 MGE1 http://www.ncbi.nlm.nih.gov/gene/?term=854407 "YOR232W, YGE1 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024639 85440 DOCK7 http://www.ncbi.nlm.nih.gov/gene/?term=85440 "EIEE23, ZIR2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024640 854419 DGA1 http://www.ncbi.nlm.nih.gov/gene/?term=854419 YOR245C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024641 85441 HELZ2 http://www.ncbi.nlm.nih.gov/gene/?term=85441 "PDIP-1, PRIC285 " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00024642 854421 SRL1 http://www.ncbi.nlm.nih.gov/gene/?term=854421 YOR247W mRNA Saccharomyces cerevisiae 18805955 Cellular bud Yeast qRT-PCR "Khd1p associates with a subset of bud-tip-localized mRNAs. ASH1, MID2, and MTL1 mRNAs, but not BRO1 mRNA, were detected by RT-PCR in RNAs isolated from total extracts (Input) and from Khd1p-TAP affinity isolations (Khd1p).overexpression inhibits ASH1 expression (Irie et al. 2002). Therefore, we systematically examined whether Khd1p modifies protein expression of other bud-tip-localized mRNAs that are bound by Khd1p (MID2, MTL1, WSC2, SRL1, EGT2, and CLB2). " RLID00024643 854421 SRL1 http://www.ncbi.nlm.nih.gov/gene/?term=854421 YOR247W mRNA Saccharomyces cerevisiae 22994588 Cytoplasm Yeast qRT-PCR "Figure 2. Deletion of AUX1 perturbs localization of WSC2, IST2, SRL1 and EAR1 mRNAs. Arrowheads indicate cytoplasmic mRNPs with tagged WSC2, IST2 or EAR1 mRNA. " RLID00024644 85442 KNDC1 http://www.ncbi.nlm.nih.gov/gene/?term=85442 "C10orf23, RASGEF2, bB439H18.3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024645 854447 TPO4 http://www.ncbi.nlm.nih.gov/gene/?term=854447 YOR273C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024646 854454 FSH3 http://www.ncbi.nlm.nih.gov/gene/?term=854454 YOR280C mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024647 854494 COT1 http://www.ncbi.nlm.nih.gov/gene/?term=854494 YOR316C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024648 854494 COT1 http://www.ncbi.nlm.nih.gov/gene/?term=854494 YOR316C mRNA Saccharomyces cerevisiae 11027259 Ribosome Yeast Northern blot "Some mRNAs exclusively localize to mitochondrion-bound polysomes, such as the ones coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p. Transcripts coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p are exclusively localized to mitochondrion-bound polysomes, while mRNAs encoding Cox6p, Cox5ap, Aac1p, and Mir1p are enriched in free cytoplasmic polysomes. The first family includes mRNAs exclusively localized to polysomes bound to mitochondria (Fig. ?(Fig.1A,1A, lanes M-P), such as ATM1, COX10, TIM44, ATP2, and COT1 mRNAs. " RLID00024649 854495 FAA1 http://www.ncbi.nlm.nih.gov/gene/?term=854495 YOR317W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024650 85449 KIAA1755 http://www.ncbi.nlm.nih.gov/gene/?term=85449 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024651 85449 KIAA1755 http://www.ncbi.nlm.nih.gov/gene/?term=85449 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024652 8544 PIR http://www.ncbi.nlm.nih.gov/gene/?term=8544 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024653 854504 MYO2 http://www.ncbi.nlm.nih.gov/gene/?term=854504 "YOR326W, CDC66 " mRNA Saccharomyces cerevisiae 21705432 Cellular bud Yeast Microarray|RT-PCR "We found that tagged ASH1 and MYO2 mRNAs both localized to the bud tip and showed only a very low level of colocalization with mitochondria (e.g., 18% and 12%, respectively) (Table 1). " RLID00024654 85450 ITPRIP http://www.ncbi.nlm.nih.gov/gene/?term=85450 "DANGER, KIAA1754, bA127L20, bA127L20.2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024655 85451 UNK http://www.ncbi.nlm.nih.gov/gene/?term=85451 "UNKEMPT, ZC3H5, ZC3HDC5 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024656 85452 CFAP74 http://www.ncbi.nlm.nih.gov/gene/?term=85452 "C1orf222, KIAA1751 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024657 85452 CFAP74 http://www.ncbi.nlm.nih.gov/gene/?term=85452 "C1orf222, KIAA1751 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024658 854538 CIR2 http://www.ncbi.nlm.nih.gov/gene/?term=854538 YOR356W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024659 854556 ALD4 http://www.ncbi.nlm.nih.gov/gene/?term=854556 "YOR374W, ALD7 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024660 85456 TNKS1BP1 http://www.ncbi.nlm.nih.gov/gene/?term=85456 TAB182 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024661 85458 DIXDC1 http://www.ncbi.nlm.nih.gov/gene/?term=85458 CCD1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024662 85459 CEP295 http://www.ncbi.nlm.nih.gov/gene/?term=85459 KIAA1731 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024663 854622 COX2 http://www.ncbi.nlm.nih.gov/gene/?term=854622 "Q0250, OXI1, OXII " mRNA Pisum sativum 11788705 Mitochondrion Pea RT-PCR RT-PCR analysis of 5' to 3'-end-ligated mRNAs identifies the extremities of cox2 transcripts in pea mitochondria. RLID00024664 85462 FHDC1 http://www.ncbi.nlm.nih.gov/gene/?term=85462 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024665 85462 FHDC1 http://www.ncbi.nlm.nih.gov/gene/?term=85462 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024666 854636 HXT12 http://www.ncbi.nlm.nih.gov/gene/?term=854636 YIL170W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024667 85463 ZC3H12C http://www.ncbi.nlm.nih.gov/gene/?term=85463 MCPIP3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024668 854642 NIT1 http://www.ncbi.nlm.nih.gov/gene/?term=854642 YIL164C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024669 854644 SUC2 http://www.ncbi.nlm.nih.gov/gene/?term=854644 YIL162W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024670 854644 SUC2 http://www.ncbi.nlm.nih.gov/gene/?term=854644 YIL162W mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024671 854644 SUC2 http://www.ncbi.nlm.nih.gov/gene/?term=854644 YIL162W mRNA Saccharomyces cerevisiae 23904265 Endoplasmic reticulum Yeast Confocal microscopy "We examined mRNA localization by confocal microscopy and found that 9 of 11 mSMPs tagged (ALG1, GOS1, ICE2, PEP12, PMT2, SUC2, SUR4, USE1, and YIP3) showed high levels of granule colocalization with ER (>70%; Figure 1 and Table 1), and 2 (NYV1 and SEC22) showed lower levels of ER localization (56%; Figure 1 and Table 1). A similar low level of ER localization was observed with two mRNAs that encode soluble SNAREs (SEC9 and SEC20) known to associate with the plasma and ER membranes (Figure 1 and Table 1). Of interest, some preference toward nER localization was observed with mSMPs such as PMT2, SUC2, SUR4, USE1, and YIP3, whereas in contrast, most of the mRNAs encoding SNAREs (e.g., GOS1, NYV1, PEP12, SEC9, and SEC22) demonstrated a preference for cER (Table 1). Data are collected from Table 1. " RLID00024672 854651 GUT2 http://www.ncbi.nlm.nih.gov/gene/?term=854651 YIL155C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024673 85465 EPT1 http://www.ncbi.nlm.nih.gov/gene/?term=85465 "SELI, SEPI " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024674 854666 AXL2 http://www.ncbi.nlm.nih.gov/gene/?term=854666 "YIL140W, BUD10, SRO4 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024675 854668 TPM2 http://www.ncbi.nlm.nih.gov/gene/?term=854668 YIL138C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024676 854670 OM45 http://www.ncbi.nlm.nih.gov/gene/?term=854670 YIL136W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024677 854681 KGD1 http://www.ncbi.nlm.nih.gov/gene/?term=854681 "YIL125W, OGD1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024678 854681 KGD1 http://www.ncbi.nlm.nih.gov/gene/?term=854681 "YIL125W, OGD1 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024679 854683 SIM1 http://www.ncbi.nlm.nih.gov/gene/?term=854683 YIL123W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024680 854685 QDR2 http://www.ncbi.nlm.nih.gov/gene/?term=854685 YIL121W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024681 854688 RHO3 http://www.ncbi.nlm.nih.gov/gene/?term=854688 YIL118W mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization "As SEC4 mRNA is asymmetrically distributed to the bud prior to nuclear division, similar to ASH1 mRNA, we examined the localization of other POL mRNAs by FISH (Fig. 1B). Endogenous mRNAs encoding the Cdc42 and Rho3 GTPases (31); the Sec1, Sro7, and Sro77 SNARE regulators (23,25); the Sec3 and Exo84 exocyst components (27); and Ypt1, a GTPase involved in ER-Golgi transport, localized at least in part to the buds of G2/M phase cells prior to nuclear division. This pattern was discerned in �0% of cells for each mRNA examined (Fig. 1B), indicating that these mRNAs were also exported from mother cells. Asymmetric POL mRNA localization correlates with the bud-specific pattern of protein localization seen during cell division. " RLID00024682 854688 RHO3 http://www.ncbi.nlm.nih.gov/gene/?term=854688 YIL118W mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization Figure 1B: Endogenous mRNAs encoding bud-localized proteins also localize to the bud tip prior to nuclear division. WT yeast cells were treated as above and hybridized in situ with specific digoxigenin-labeled RNA antisense probes for different POL genes (as labeled). Representative small-budded (early G2/M) cells are shown. Data are collected from Figure 1B. RLID00024683 854714 LYS12 http://www.ncbi.nlm.nih.gov/gene/?term=854714 "YIL094C, LYS10, LYS11 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024684 854718 ICE2 http://www.ncbi.nlm.nih.gov/gene/?term=854718 YIL090W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024685 854718 ICE2 http://www.ncbi.nlm.nih.gov/gene/?term=854718 YIL090W mRNA Saccharomyces cerevisiae 23904265 Endoplasmic reticulum Yeast Confocal microscopy "We examined mRNA localization by confocal microscopy and found that 9 of 11 mSMPs tagged (ALG1, GOS1, ICE2, PEP12, PMT2, SUC2, SUR4, USE1, and YIP3) showed high levels of granule colocalization with ER (>70%; Figure 1 and Table 1), and 2 (NYV1 and SEC22) showed lower levels of ER localization (56%; Figure 1 and Table 1). A similar low level of ER localization was observed with two mRNAs that encode soluble SNAREs (SEC9 and SEC20) known to associate with the plasma and ER membranes (Figure 1 and Table 1). Of interest, some preference toward nER localization was observed with mSMPs such as PMT2, SUC2, SUR4, USE1, and YIP3, whereas in contrast, most of the mRNAs encoding SNAREs (e.g., GOS1, NYV1, PEP12, SEC9, and SEC22) demonstrated a preference for cER (Table 1). Data are collected from Table 1. " RLID00024686 854721 AVT7 http://www.ncbi.nlm.nih.gov/gene/?term=854721 YIL088C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024687 854764 SYG1 http://www.ncbi.nlm.nih.gov/gene/?term=854764 YIL047C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024688 854765 MET30 http://www.ncbi.nlm.nih.gov/gene/?term=854765 "YIL046W, ZRG11 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024689 854769 PKP1 http://www.ncbi.nlm.nih.gov/gene/?term=854769 YIL042C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024690 85476 GFM1 http://www.ncbi.nlm.nih.gov/gene/?term=85476 "COXPD1, EFG, EFG1, EFGM, EGF1, GFM, hEFG1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024691 85476 GFM1 http://www.ncbi.nlm.nih.gov/gene/?term=85476 "COXPD1, EFG, EFG1, EFGM, EGF1, GFM, hEFG1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024692 854771 APQ12 http://www.ncbi.nlm.nih.gov/gene/?term=854771 YIL040W mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024693 854772 TED1 http://www.ncbi.nlm.nih.gov/gene/?term=854772 YIL039W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024694 854781 SSM4 http://www.ncbi.nlm.nih.gov/gene/?term=854781 "YIL030C, DOA10, KIS3 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024695 854790 TIM44 http://www.ncbi.nlm.nih.gov/gene/?term=854790 "YIL022W, ISP45, MIM44, MPI1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024696 854790 TIM44 http://www.ncbi.nlm.nih.gov/gene/?term=854790 "YIL022W, ISP45, MIM44, MPI1 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024697 854790 TIM44 http://www.ncbi.nlm.nih.gov/gene/?term=854790 "YIL022W, ISP45, MIM44, MPI1 " mRNA Saccharomyces cerevisiae 11027259 Ribosome Yeast Northern blot "Some mRNAs exclusively localize to mitochondrion-bound polysomes, such as the ones coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p. Transcripts coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p are exclusively localized to mitochondrion-bound polysomes, while mRNAs encoding Cox6p, Cox5ap, Aac1p, and Mir1p are enriched in free cytoplasmic polysomes. The first family includes mRNAs exclusively localized to polysomes bound to mitochondria (Fig. ?(Fig.1A,1A, lanes M-P), such as ATM1, COX10, TIM44, ATP2, and COT1 mRNAs. " RLID00024698 854841 DAL81 http://www.ncbi.nlm.nih.gov/gene/?term=854841 "YIR023W, UGA35 " mRNA Saccharomyces cerevisiae 17094940 Cellular bud Yeast Fluorescence in situ hybridization "As described above, the long sequences of these mRNAs (3.4 kb ORF for CSR2 and 2.9 kb ORF for DAL81) might generate signals of the nucleus. To confirm that, 30 -tagged mRNAs, CSR2-U1A and DAL81-U1A, were constructed by insertion of the 4· U1A-tag between their ORF and 30-UTR. CSR2-U1A and DAL81-U1A were expressed from the GAL1 promoter and subjected to the U1A-tag-GFP system. They were detected at the bud-tip but not in the nucleus (Fig. 3A, c and g), whereas signals of both the 50-tagged and the 30-tagged mRNAs were detected in the nucleus and at the bud-tip by in situ hybridization (Fig. 3A, FISH column). These results suggested that CSR2 and DAL81 mRNAs were localized at the bud-tip after transcription. " RLID00024699 854857 YPS6 http://www.ncbi.nlm.nih.gov/gene/?term=854857 YIR039C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024700 854861 YIR043C http://www.ncbi.nlm.nih.gov/gene/?term=854861 "YIR043C, YIR044C " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024701 854872 TSL1 http://www.ncbi.nlm.nih.gov/gene/?term=854872 YML100W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024702 854883 RPM2 http://www.ncbi.nlm.nih.gov/gene/?term=854883 YML091C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024703 854886 UFO1 http://www.ncbi.nlm.nih.gov/gene/?term=854886 YML088W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024704 854889 TUB1 http://www.ncbi.nlm.nih.gov/gene/?term=854889 YML085C mRNA Saccharomyces cerevisiae 17339339 Endoplasmic reticulum Yeast RT-PCR "Importantly, mRNAs encoding Sec4, Cdc42, Sro7, and Snc1 were specifically enriched in the ER fraction, along with ASH1 mRNA (Fig. 9B), which was shown to be enriched on the ER (18). mRNAs encoding RDN18, a ribosomal rRNA, and TUB1 were found in both the ER and cytosolic fractions (Fig. 9B). " RLID00024705 854889 TUB1 http://www.ncbi.nlm.nih.gov/gene/?term=854889 YML085C mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization Figure 1B: Endogenous mRNAs encoding bud-localized proteins also localize to the bud tip prior to nuclear division. WT yeast cells were treated as above and hybridized in situ with specific digoxigenin-labeled RNA antisense probes for different POL genes (as labeled). Representative small-budded (early G2/M) cells are shown. Data are collected from Figure 1B. RLID00024706 854889 TUB1 http://www.ncbi.nlm.nih.gov/gene/?term=854889 YML085C mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024707 8548 BLZF1 http://www.ncbi.nlm.nih.gov/gene/?term=8548 "GOLGIN-45, JEM-1, JEM-1s, JEM1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024708 8548 BLZF1 http://www.ncbi.nlm.nih.gov/gene/?term=8548 "GOLGIN-45, JEM-1, JEM-1s, JEM1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024709 854907 COS3 http://www.ncbi.nlm.nih.gov/gene/?term=854907 YML132W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024710 854911 MSC1 http://www.ncbi.nlm.nih.gov/gene/?term=854911 YML128C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024711 854919 NDI1 http://www.ncbi.nlm.nih.gov/gene/?term=854919 YML120C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024712 854925 VAN1 http://www.ncbi.nlm.nih.gov/gene/?term=854925 "YML115C, LDB13, VRG7, VRG8 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024713 854930 COQ5 http://www.ncbi.nlm.nih.gov/gene/?term=854930 "YML110C, DBI56 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024714 854950 CYB2 http://www.ncbi.nlm.nih.gov/gene/?term=854950 "YML054C, FCB2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024715 854950 CYB2 http://www.ncbi.nlm.nih.gov/gene/?term=854950 "YML054C, FCB2 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024716 854950 CYB2 http://www.ncbi.nlm.nih.gov/gene/?term=854950 "YML054C, FCB2 " mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR TABLE 1: Localization of mRNAs encoding mitochondrial proteins in yeast. Data are collected from Table 1. RLID00024717 854950 CYB2 http://www.ncbi.nlm.nih.gov/gene/?term=854950 "YML054C, FCB2 " mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR "Out of 24 tagged mMPs, we found that the ATM1, ATP2, ATP10, CYB2, COX10,MDM10, and OXA1 mRNA granules exhibited very high levels of colocalization with mitochondria (e.g., >80%), while the CBS1, CYC3, and FIS1 mRNAs demonstrated low levels of colocalization (i.e., �4%) on glucose-containing medium (Fig. 1A; Table 1). Taken together, the data suggest that the 3�UTR is necessary for ATP2 and OXA1 mRNA localization to mitochondria (Table 3). " RLID00024718 85495 RPPH1 http://www.ncbi.nlm.nih.gov/gene/?term=85495 "H1RNA-1, RPPH1 " lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024719 85495 RPPH1 http://www.ncbi.nlm.nih.gov/gene/?term=85495 "H1RNA-1, RPPH1 " tRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00024720 85495 RPPH1 http://www.ncbi.nlm.nih.gov/gene/?term=85495 "H1RNA-1, RPPH1 " lncRNA Homo sapiens 25690653 Cytoplasm P493-6 cell qRT-PCR "To validate the isolation of nuclear and cytoplasmic fractions, the enrichment of 3 nuclear (ANRIL, MIAT, XIST) and 3 cytoplasmic (RPPH1, DANCR, tRNA-Lys) RNAs was analyzed by qRT-PCR. " RLID00024721 854969 YML039W http://www.ncbi.nlm.nih.gov/gene/?term=854969 YML039W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024722 8549 LGR5 http://www.ncbi.nlm.nih.gov/gene/?term=8549 "FEX, GPR49, GPR67, GRP49, HG38 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024723 8549 LGR5 http://www.ncbi.nlm.nih.gov/gene/?term=8549 "FEX, GPR49, GPR67, GRP49, HG38 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024724 8549 LGR5 http://www.ncbi.nlm.nih.gov/gene/?term=8549 "FEX, GPR49, GPR67, GRP49, HG38 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024725 855020 PLB1 http://www.ncbi.nlm.nih.gov/gene/?term=855020 YMR008C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024726 855023 HXT2 http://www.ncbi.nlm.nih.gov/gene/?term=855023 YMR011W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024727 855029 ERG5 http://www.ncbi.nlm.nih.gov/gene/?term=855029 "YMR015C, CYP61 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024728 855041 PEX12 http://www.ncbi.nlm.nih.gov/gene/?term=855041 "YMR026C, PAS11 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024729 855041 PEX12 http://www.ncbi.nlm.nih.gov/gene/?term=855041 "YMR026C, PAS11 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024730 855061 IOC4 http://www.ncbi.nlm.nih.gov/gene/?term=855061 YMR044W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024731 855070 YMR050C http://www.ncbi.nlm.nih.gov/gene/?term=855070 YMR050C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024732 855078 AAC1 http://www.ncbi.nlm.nih.gov/gene/?term=855078 YMR056C mRNA Saccharomyces cerevisiae 11027259 Ribosome Yeast Northern blot "In contrast, mRNAs encoding Cox6p, Cox5a, Aac1p, and Mir1p are found enriched in free cytoplasmic polysome fractions. Transcripts coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p are exclusively localized to mitochondrion-bound polysomes, while mRNAs encoding Cox6p, Cox5ap, Aac1p, and Mir1p are enriched in free cytoplasmic polysomes. The third family mRNAs were those predominantly associated with free cytoplasmic polysomes (Fig. ?(Fig.1A,1A, lanes F-P), such as COX6, COX5a, AAC1, and MIR1. " RLID00024733 855134 SPG4 http://www.ncbi.nlm.nih.gov/gene/?term=855134 YMR107W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024734 855176 NDE1 http://www.ncbi.nlm.nih.gov/gene/?term=855176 "YMR145C, NDH1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024735 855198 INP2 http://www.ncbi.nlm.nih.gov/gene/?term=855198 YMR163C mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024736 855207 EAR1 http://www.ncbi.nlm.nih.gov/gene/?term=855207 YMR171C mRNA Saccharomyces cerevisiae 20713510 Cellular bud Yeast Chip-seq "In yeast, the RNA-binding protein She2p binds several mRNAs and targets them for localization at the bud. Here we report that She2p is recruited cotranscriptionally to the nascent bud-localized ASH1, IST2, and EAR1 mRNA. " RLID00024737 855207 EAR1 http://www.ncbi.nlm.nih.gov/gene/?term=855207 YMR171C mRNA Saccharomyces cerevisiae 22994588 Cytoplasm Yeast qRT-PCR "Figure 2. Deletion of AUX1 perturbs localization of WSC2, IST2, SRL1 and EAR1 mRNAs. Arrowheads indicate cytoplasmic mRNPs with tagged WSC2, IST2 or EAR1 mRNA. " RLID00024738 855229 SPG5 http://www.ncbi.nlm.nih.gov/gene/?term=855229 YMR191W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024739 855231 MRPL24 http://www.ncbi.nlm.nih.gov/gene/?term=855231 YMR193W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024740 855240 ROT1 http://www.ncbi.nlm.nih.gov/gene/?term=855240 YMR200W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024741 855284 ZRC1 http://www.ncbi.nlm.nih.gov/gene/?term=855284 "YMR243C, OSR1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024742 855315 SCS7 http://www.ncbi.nlm.nih.gov/gene/?term=855315 "YMR272C, FAH1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024743 855335 HAS1 http://www.ncbi.nlm.nih.gov/gene/?term=855335 YMR290C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024744 855343 PRC1 http://www.ncbi.nlm.nih.gov/gene/?term=855343 "YMR297W, CPY1, LBC1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024745 855343 PRC1 http://www.ncbi.nlm.nih.gov/gene/?term=855343 "YMR297W, CPY1, LBC1 " mRNA Saccharomyces cerevisiae 8405926 Ribosome Yeast Northern blot "Fig. 1. Segregation of secretory protein mRNA to membrane- bound ribosomes. Northern blot analysis with CYH2, PRC1 and PH05. DNA fragments from the genes CYH2, PRC1 and PH05 hybridized to a Northern blot of 1 ug poly(A)+-RNA from membrane-bound (MBP) and free polysomes (FP). Data are collected from Figure 1. " RLID00024746 855347 ATM1 http://www.ncbi.nlm.nih.gov/gene/?term=855347 YMR301C mRNA Saccharomyces cerevisiae 11027259 Ribosome Yeast Northern blot "Some mRNAs exclusively localize to mitochondrion-bound polysomes, such as the ones coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p. Transcripts coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p are exclusively localized to mitochondrion-bound polysomes, while mRNAs encoding Cox6p, Cox5ap, Aac1p, and Mir1p are enriched in free cytoplasmic polysomes. The first family includes mRNAs exclusively localized to polysomes bound to mitochondria (Fig.(Fig.1A,1A, lanes M-P), such as ATM1, COX10, TIM44, ATP2, and COT1 mRNAs. " RLID00024747 855347 ATM1 http://www.ncbi.nlm.nih.gov/gene/?term=855347 YMR301C mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR "Out of 24 tagged mMPs, we found that the ATM1, ATP2, ATP10, CYB2, COX10,MDM10, and OXA1 mRNA granules exhibited very high levels of colocalization with mitochondria (e.g., >80%), while the CBS1, CYC3, and FIS1 mRNAs demonstrated low levels of colocalization (i.e., �4%) on glucose-containing medium (Fig. 1A; Table 1). Taken together, the data suggest that the 3�UTR is necessary for ATP2 and OXA1 mRNA localization to mitochondria (Table 3). " RLID00024748 855348 YME2 http://www.ncbi.nlm.nih.gov/gene/?term=855348 "YMR302C, PRP12, RNA12 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024749 855355 GAS1 http://www.ncbi.nlm.nih.gov/gene/?term=855355 "YMR307W, CWH52, GGP1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024750 855369 FET4 http://www.ncbi.nlm.nih.gov/gene/?term=855369 YMR319C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024751 855380 COS1 http://www.ncbi.nlm.nih.gov/gene/?term=855380 YNL336W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024752 855383 SNZ2 http://www.ncbi.nlm.nih.gov/gene/?term=855383 YNL333W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024753 855387 PEX6 http://www.ncbi.nlm.nih.gov/gene/?term=855387 "YNL329C, PAS8 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024754 855389 EGT2 http://www.ncbi.nlm.nih.gov/gene/?term=855389 YNL327W mRNA Saccharomyces cerevisiae 18805955 Cellular bud Yeast qRT-PCR "Khd1p associates with a subset of bud-tip-localized mRNAs. ASH1, MID2, and MTL1 mRNAs, but not BRO1 mRNA, were detected by RT-PCR in RNAs isolated from total extracts (Input) and from Khd1p-TAP affinity isolations (Khd1p).overexpression inhibits ASH1 expression (Irie et al. 2002). Therefore, we systematically examined whether Khd1p modifies protein expression of other bud-tip-localized mRNAs that are bound by Khd1p (MID2, MTL1, WSC2, SRL1, EGT2, and CLB2). " RLID00024755 855394 KRE1 http://www.ncbi.nlm.nih.gov/gene/?term=855394 YNL322C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024756 855411 BXI1 http://www.ncbi.nlm.nih.gov/gene/?term=855411 "YNL305C, YBH3 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024757 855422 RIM21 http://www.ncbi.nlm.nih.gov/gene/?term=855422 "YNL294C, PAL2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024758 855438 WSC2 http://www.ncbi.nlm.nih.gov/gene/?term=855438 "YNL283C, STA3 " mRNA Saccharomyces cerevisiae 18805955 Cellular bud Yeast qRT-PCR "Khd1p colocalizes with a subset of mRNAs at the bud-tip of yeast cells.The U1A-GFP-tagged RNAs for ASH1, MID2, MTL1, and WSC2 colocalized with Khd1p, whereas BRO1 and TPO4 mRNAs did not colocalize. " RLID00024759 855438 WSC2 http://www.ncbi.nlm.nih.gov/gene/?term=855438 "YNL283C, STA3 " mRNA Saccharomyces cerevisiae 22994588 Endoplasmic reticulum Yeast qRT-PCR Figure S4. Co-localization of WSC2-MS2 mRNA and ER in wild type and Δaux1 cells. WSC2-MS2 mRNA was imaged in wild type cells (RJY3786; left) or Δaux1 cells (RJY4168; right) expressing the ER marker protein Scs2-TMD-dsRed. RLID00024760 855438 WSC2 http://www.ncbi.nlm.nih.gov/gene/?term=855438 "YNL283C, STA3 " mRNA Saccharomyces cerevisiae 22994588 Cytoplasm Yeast qRT-PCR "Figure 2. Deletion of AUX1 perturbs localization of WSC2, IST2, SRL1 and EAR1 mRNAs. Arrowheads indicate cytoplasmic mRNPs with tagged WSC2, IST2 or EAR1 mRNA. " RLID00024761 855438 WSC2 http://www.ncbi.nlm.nih.gov/gene/?term=855438 "YNL283C, STA3 " mRNA Saccharomyces cerevisiae 24906800 Endoplasmic reticulum Yeast Flotation assay "For colocalization studies, MS2L-tagged WSC2 mRNA was expressed in cells carrying Rtn1-mCherry as the ER marker. Wild-type cells showed a colocalization of WSC2-MS2L mRNPs and cortical ER at the bud tip, indicating that both are transported to the bud (Fig.3A, top row). " RLID00024762 855438 WSC2 http://www.ncbi.nlm.nih.gov/gene/?term=855438 "YNL283C, STA3 " mRNA Saccharomyces cerevisiae 24906800 Cellular bud Yeast Flotation assay "For colocalization studies, MS2L-tagged WSC2 mRNA was expressed in cells carrying Rtn1-mCherry as the ER marker. Wild-type cells showed a colocalization of WSC2-MS2L mRNPs and cortical ER at the bud tip, indicating that both are transported to the bud (Fig.3A, top row). " RLID00024763 855441 ERG24 http://www.ncbi.nlm.nih.gov/gene/?term=855441 YNL280C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024764 855444 MET2 http://www.ncbi.nlm.nih.gov/gene/?term=855444 YNL277W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024765 855449 SEC2 http://www.ncbi.nlm.nih.gov/gene/?term=855449 YNL272C mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024766 8554 PIAS1 http://www.ncbi.nlm.nih.gov/gene/?term=8554 "DDXBP1, GBP, GU/RH-II, ZMIZ3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024767 855502 ALG9 http://www.ncbi.nlm.nih.gov/gene/?term=855502 YNL219C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024768 855526 YNL195C http://www.ncbi.nlm.nih.gov/gene/?term=855526 YNL195C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024769 855527 YNL194C http://www.ncbi.nlm.nih.gov/gene/?term=855527 YNL194C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024770 855529 CHS1 http://www.ncbi.nlm.nih.gov/gene/?term=855529 "YNL192W, USA4 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024771 855531 YNL190W http://www.ncbi.nlm.nih.gov/gene/?term=855531 YNL190W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024772 855562 YGP1 http://www.ncbi.nlm.nih.gov/gene/?term=855562 YNL160W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024773 855593 CPT1 http://www.ncbi.nlm.nih.gov/gene/?term=855593 YNL130C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024774 8555 CDC14B http://www.ncbi.nlm.nih.gov/gene/?term=8555 "CDC14B3, Cdc14B1, Cdc14B2, hCDC14B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024775 855602 TOM70 http://www.ncbi.nlm.nih.gov/gene/?term=855602 "YNL121C, MAS70, MOM72, OMP1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024776 855602 TOM70 http://www.ncbi.nlm.nih.gov/gene/?term=855602 "YNL121C, MAS70, MOM72, OMP1 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024777 855608 YNL115C http://www.ncbi.nlm.nih.gov/gene/?term=855608 YNL115C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024778 855619 LEU4 http://www.ncbi.nlm.nih.gov/gene/?term=855619 YNL104C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024779 855630 APP1 http://www.ncbi.nlm.nih.gov/gene/?term=855630 YNL094W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024780 855653 LAT1 http://www.ncbi.nlm.nih.gov/gene/?term=855653 "YNL071W, ODP2, PDA2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024781 855675 COX5A http://www.ncbi.nlm.nih.gov/gene/?term=855675 YNL052W mRNA Saccharomyces cerevisiae 11027259 Ribosome Yeast Northern blot "In contrast, mRNAs encoding Cox6p, Cox5a, Aac1p, and Mir1p are found enriched in free cytoplasmic polysome fractions. Transcripts coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p are exclusively localized to mitochondrion-bound polysomes, while mRNAs encoding Cox6p, Cox5ap, Aac1p, and Mir1p are enriched in free cytoplasmic polysomes. The third family mRNAs were those predominantly associated with free cytoplasmic polysomes (Fig. ?(Fig.1A,1A, lanes F-P), such as COX6, COX5a, AAC1, and MIR1. " RLID00024782 855683 YIP3 http://www.ncbi.nlm.nih.gov/gene/?term=855683 YNL044W mRNA Saccharomyces cerevisiae 21705432 Cell cortex Yeast Microarray|RT-PCR "We found that the USE1 and YIP3 mRNAs localized primarily with ER peripheral to the nucleus (nuclear ER; nER) (i.e., 52% colocalization with nER and 26% colocalization with cER for USE1 [78% ER total]; and 40% colocalization with nER and 29% colocalization with cER for YIP3 [69% ER total]) (data not shown), but exhibited only low levels of colocalization with mitochondria (e.g., 28% and 32%) (Table 1). " RLID00024783 855683 YIP3 http://www.ncbi.nlm.nih.gov/gene/?term=855683 YNL044W mRNA Saccharomyces cerevisiae 21705432 Nucleus Yeast Microarray|RT-PCR "We found that the USE1 and YIP3 mRNAs localized primarily with ER peripheral to the nucleus (nuclear ER; nER) (i.e., 52% colocalization with nER and 26% colocalization with cER for USE1 [78% ER total]; and 40% colocalization with nER and 29% colocalization with cER for YIP3 [69% ER total]) (data not shown), but exhibited only low levels of colocalization with mitochondria (e.g., 28% and 32%) (Table 1). " RLID00024784 855683 YIP3 http://www.ncbi.nlm.nih.gov/gene/?term=855683 YNL044W mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024785 855683 YIP3 http://www.ncbi.nlm.nih.gov/gene/?term=855683 YNL044W mRNA Saccharomyces cerevisiae 23904265 Endoplasmic reticulum Yeast Confocal microscopy "We examined mRNA localization by confocal microscopy and found that 9 of 11 mSMPs tagged (ALG1, GOS1, ICE2, PEP12, PMT2, SUC2, SUR4, USE1, and YIP3) showed high levels of granule colocalization with ER (>70%; Figure 1 and Table 1), and 2 (NYV1 and SEC22) showed lower levels of ER localization (56%; Figure 1 and Table 1). A similar low level of ER localization was observed with two mRNAs that encode soluble SNAREs (SEC9 and SEC20) known to associate with the plasma and ER membranes (Figure 1 and Table 1). Of interest, some preference toward nER localization was observed with mSMPs such as PMT2, SUC2, SUR4, USE1, and YIP3, whereas in contrast, most of the mRNAs encoding SNAREs (e.g., GOS1, NYV1, PEP12, SEC9, and SEC22) demonstrated a preference for cER (Table 1). Data are collected from Table 1. " RLID00024786 855691 IDH1 http://www.ncbi.nlm.nih.gov/gene/?term=855691 YNL037C mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024787 8556 CDC14A http://www.ncbi.nlm.nih.gov/gene/?term=8556 "cdc14, hCDC14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024788 855705 SAM50 http://www.ncbi.nlm.nih.gov/gene/?term=855705 "YNL026W, OMP85, TOB55 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024789 855723 IDP3 http://www.ncbi.nlm.nih.gov/gene/?term=855723 YNL009W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024790 855732 CIT1 http://www.ncbi.nlm.nih.gov/gene/?term=855732 "YNR001C, LYS6 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024791 855732 CIT1 http://www.ncbi.nlm.nih.gov/gene/?term=855732 "YNR001C, LYS6 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024792 855732 CIT1 http://www.ncbi.nlm.nih.gov/gene/?term=855732 "YNR001C, LYS6 " mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR TABLE 1: Localization of mRNAs encoding mitochondrial proteins in yeast. Data are collected from Table 1. RLID00024793 855753 ARE2 http://www.ncbi.nlm.nih.gov/gene/?term=855753 "YNR019W, SAT1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024794 8557 TCAP http://www.ncbi.nlm.nih.gov/gene/?term=8557 "CMD1N, CMH25, LGMD2G, T-cap, TELE, telethonin " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024795 855866 FUM1 http://www.ncbi.nlm.nih.gov/gene/?term=855866 YPL262W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024796 855866 FUM1 http://www.ncbi.nlm.nih.gov/gene/?term=855866 YPL262W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024797 855879 FMP40 http://www.ncbi.nlm.nih.gov/gene/?term=855879 YPL222W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024798 855883 SAR1 http://www.ncbi.nlm.nih.gov/gene/?term=855883 YPL218W mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024799 855886 CBP3 http://www.ncbi.nlm.nih.gov/gene/?term=855886 YPL215W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024800 855914 MF(ALPHA)1 http://www.ncbi.nlm.nih.gov/gene/?term=855914 YPL187W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024801 855927 TRE1 http://www.ncbi.nlm.nih.gov/gene/?term=855927 YPL176C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024802 855931 COX10 http://www.ncbi.nlm.nih.gov/gene/?term=855931 YPL172C mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024803 855931 COX10 http://www.ncbi.nlm.nih.gov/gene/?term=855931 YPL172C mRNA Saccharomyces cerevisiae 11027259 Ribosome Yeast Northern blot "Some mRNAs exclusively localize to mitochondrion-bound polysomes, such as the ones coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p. Transcripts coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p are exclusively localized to mitochondrion-bound polysomes, while mRNAs encoding Cox6p, Cox5ap, Aac1p, and Mir1p are enriched in free cytoplasmic polysomes. The first family includes mRNAs exclusively localized to polysomes bound to mitochondria (Fig. ?(Fig.1A,1A, lanes M-P), such as ATM1, COX10, TIM44, ATP2, and COT1 mRNAs. " RLID00024804 855931 COX10 http://www.ncbi.nlm.nih.gov/gene/?term=855931 YPL172C mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR TABLE 1: Localization of mRNAs encoding mitochondrial proteins in yeast. Data are collected from Table 1. RLID00024805 855931 COX10 http://www.ncbi.nlm.nih.gov/gene/?term=855931 YPL172C mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR "Out of 24 tagged mMPs, we found that the ATM1, ATP2, ATP10, CYB2, COX10,MDM10, and OXA1 mRNA granules exhibited very high levels of colocalization with mitochondria (e.g., >80%), while the CBS1, CYC3, and FIS1 mRNAs demonstrated low levels of colocalization (i.e., �4%) on glucose-containing medium (Fig. 1A; Table 1). Taken together, the data suggest that the 3�UTR is necessary for ATP2 and OXA1 mRNA localization to mitochondria (Table 3). " RLID00024806 855949 PEP4 http://www.ncbi.nlm.nih.gov/gene/?term=855949 "YPL154C, PHO9, PRA1, yscA " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024807 855956 PXA1 http://www.ncbi.nlm.nih.gov/gene/?term=855956 "YPL147W, LPI1, PAL1, PAT2, SSH2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024808 855956 PXA1 http://www.ncbi.nlm.nih.gov/gene/?term=855956 "YPL147W, LPI1, PAL1, PAT2, SSH2 " mRNA Saccharomyces cerevisiae 19903887 Peroxisome Yeast RT-PCR "To examine endogenous mPP localization, we used m-TAG to create strains tagged with the MS2L sequence (Table S1). We first localized mRNAs encoding proteins involved in peroxisome biogenesis, called peroxins (PEX1-3, 5-8, 10-15, 17, 19, 21, 22, 27-30, and 32). On the expression of MS2-CP-GFP(x3) in cells bearing the tagged genes, we observed that few had fluorescent RNA granules when grown on glucose-containing medium. But when grown under conditions that induce peroxisome proliferation (i.e., media containing oleate), we saw a large increase in the number of cells bearing fluorescent granules. We then determined that between 56% and 80% of granules seen in the MS2L-tagged PEX1, 5, 8, 11, 12, 13, 14, or 15 strains colocalized with peroxisomes labeled with a peroxisomal matrix marker, RFP-PTS1 (68%, 56%, 66%, 80%, 58%, 78%, 60%, and 78% colocalization, respectively; Fig. 1A and Table S2). Thus, mPPs associate with peroxisomes, although we noted that the number of RFP-labeled peroxisomes observed per cell (2-6) was usually greater than the number of granules (1-3). This may indicate that mPPs are in transient/intermittent association with peroxisomes, or that there are distinct (i.e., mature) peroxisomes that do not associate with mRNA. Data are collected from Table S2. " RLID00024809 855956 PXA1 http://www.ncbi.nlm.nih.gov/gene/?term=855956 "YPL147W, LPI1, PAL1, PAT2, SSH2 " mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024810 855969 ODC1 http://www.ncbi.nlm.nih.gov/gene/?term=855969 YPL134C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024811 855971 COX11 http://www.ncbi.nlm.nih.gov/gene/?term=855971 "YPL132W, LPI13, PSO7 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024812 8559 PRPF18 http://www.ncbi.nlm.nih.gov/gene/?term=8559 "PRP18, hPrp18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024813 856002 ELP4 http://www.ncbi.nlm.nih.gov/gene/?term=856002 "YPL101W, HAP1, KTI9, TOT7 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024814 856021 BRO1 http://www.ncbi.nlm.nih.gov/gene/?term=856021 "YPL084W, ASI6, LPF2, NPI3, VPS31 " mRNA Saccharomyces cerevisiae 18805955 Cellular bud Yeast qRT-PCR "Khd1p associates with a subset of bud-tip-localized mRNAs. ASH1, MID2, and MTL1 mRNAs, but not BRO1 mRNA, were detected by RT-PCR in RNAs isolated from total extracts (Input) and from Khd1p-TAP affinity isolations (Khd1p).overexpression inhibits ASH1 expression (Irie et al. 2002). Therefore, we systematically examined whether Khd1p modifies protein expression of other bud-tip-localized mRNAs that are bound by Khd1p (MID2, MTL1, WSC2, SRL1, EGT2, and CLB2). " RLID00024815 856027 ATP4 http://www.ncbi.nlm.nih.gov/gene/?term=856027 "YPL078C, LPF7 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024816 856027 ATP4 http://www.ncbi.nlm.nih.gov/gene/?term=856027 "YPL078C, LPF7 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024817 856042 TIM50 http://www.ncbi.nlm.nih.gov/gene/?term=856042 YPL063W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024818 856042 TIM50 http://www.ncbi.nlm.nih.gov/gene/?term=856042 YPL063W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024819 856050 SUR1 http://www.ncbi.nlm.nih.gov/gene/?term=856050 "YPL057C, BCL21, CSG1, LPE15 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024820 856054 KTR6 http://www.ncbi.nlm.nih.gov/gene/?term=856054 "YPL053C, MNN6 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024821 856071 PMA2 http://www.ncbi.nlm.nih.gov/gene/?term=856071 YPL036W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024822 8560 DEGS1 http://www.ncbi.nlm.nih.gov/gene/?term=8560 "DEGS, DEGS-1, DES1, Des-1, FADS7, MIG15, MLD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024823 8560 DEGS1 http://www.ncbi.nlm.nih.gov/gene/?term=8560 "DEGS, DEGS-1, DES1, Des-1, FADS7, MIG15, MLD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024824 856107 CIT3 http://www.ncbi.nlm.nih.gov/gene/?term=856107 YPR001W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024825 856107 CIT3 http://www.ncbi.nlm.nih.gov/gene/?term=856107 YPR001W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024826 856137 ATH1 http://www.ncbi.nlm.nih.gov/gene/?term=856137 YPR026W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024827 856142 CSR2 http://www.ncbi.nlm.nih.gov/gene/?term=856142 "YPR030W, ART8, MRG19 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024828 856142 CSR2 http://www.ncbi.nlm.nih.gov/gene/?term=856142 "YPR030W, ART8, MRG19 " mRNA Saccharomyces cerevisiae 17094940 Cellular bud Yeast Fluorescence in situ hybridization "As described above, the long sequences of these mRNAs (3.4 kb ORF for CSR2 and 2.9 kb ORF for DAL81) might generate signals of the nucleus. To confirm that, 30 -tagged mRNAs, CSR2-U1A and DAL81-U1A, were constructed by insertion of the 4· U1A-tag between their ORF and 30-UTR. CSR2-U1A and DAL81-U1A were expressed from the GAL1 promoter and subjected to the U1A-tag-GFP system. They were detected at the bud-tip but not in the nucleus (Fig. 3A, c and g), whereas signals of both the 50-tagged and the 30-tagged mRNAs were detected in the nucleus and at the bud-tip by in situ hybridization (Fig. 3A, FISH column). These results suggested that CSR2 and DAL81 mRNAs were localized at the bud-tip after transcription. " RLID00024829 856144 SRO7 http://www.ncbi.nlm.nih.gov/gene/?term=856144 "YPR032W, SNI1, SOP1 " mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization "As SEC4 mRNA is asymmetrically distributed to the bud prior to nuclear division, similar to ASH1 mRNA, we examined the localization of other POL mRNAs by FISH (Fig. 1B). Endogenous mRNAs encoding the Cdc42 and Rho3 GTPases (31); the Sec1, Sro7, and Sro77 SNARE regulators (23,25); the Sec3 and Exo84 exocyst components (27); and Ypt1, a GTPase involved in ER-Golgi transport, localized at least in part to the buds of G2/M phase cells prior to nuclear division. This pattern was discerned in �0% of cells for each mRNA examined (Fig. 1B), indicating that these mRNAs were also exported from mother cells. Asymmetric POL mRNA localization correlates with the bud-specific pattern of protein localization seen during cell division. " RLID00024830 856144 SRO7 http://www.ncbi.nlm.nih.gov/gene/?term=856144 "YPR032W, SNI1, SOP1 " mRNA Saccharomyces cerevisiae 17339339 Endoplasmic reticulum Yeast RT-PCR "Importantly, mRNAs encoding Sec4, Cdc42, Sro7, and Snc1 were specifically enriched in the ER fraction, along with ASH1 mRNA (Fig. 9B), which was shown to be enriched on the ER (18). mRNAs encoding RDN18, a ribosomal rRNA, and TUB1 were found in both the ER and cytosolic fractions (Fig. 9B). " RLID00024831 856144 SRO7 http://www.ncbi.nlm.nih.gov/gene/?term=856144 "YPR032W, SNI1, SOP1 " mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization Figure 1B: Endogenous mRNAs encoding bud-localized proteins also localize to the bud tip prior to nuclear division. WT yeast cells were treated as above and hybridized in situ with specific digoxigenin-labeled RNA antisense probes for different POL genes (as labeled). Representative small-budded (early G2/M) cells are shown. Data are collected from Figure 1B. RLID00024832 856144 SRO7 http://www.ncbi.nlm.nih.gov/gene/?term=856144 "YPR032W, SNI1, SOP1 " mRNA Saccharomyces cerevisiae 17417645 Endoplasmic reticulum Yeast qRT-PCR "We previously demonstrated that SRO7 mRNA undergoes polarized transport, along with cortical ER, to the bud tip11. Thus, PEX3 mRNA localizes to the endoplasmic reticulum, as seen previously11, and Pex3 is functional after MS2L integration into the PEX3 locus. We observed typical tubular-punctate mitochondrial morphology with Oxa1-RFP19. " RLID00024833 856144 SRO7 http://www.ncbi.nlm.nih.gov/gene/?term=856144 "YPR032W, SNI1, SOP1 " mRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00024834 856236 CLB2 http://www.ncbi.nlm.nih.gov/gene/?term=856236 YPR119W mRNA Saccharomyces cerevisiae 18805955 Cellular bud Yeast qRT-PCR "Khd1p associates with a subset of bud-tip-localized mRNAs. ASH1, MID2, and MTL1 mRNAs, but not BRO1 mRNA, were detected by RT-PCR in RNAs isolated from total extracts (Input) and from Khd1p-TAP affinity isolations (Khd1p).overexpression inhibits ASH1 expression (Irie et al. 2002). Therefore, we systematically examined whether Khd1p modifies protein expression of other bud-tip-localized mRNAs that are bound by Khd1p (MID2, MTL1, WSC2, SRL1, EGT2, and CLB2). " RLID00024835 856243 YLH47 http://www.ncbi.nlm.nih.gov/gene/?term=856243 "YPR125W, MRS7 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024836 856271 YPR148C http://www.ncbi.nlm.nih.gov/gene/?term=856271 YPR148C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024837 856272 NCE102 http://www.ncbi.nlm.nih.gov/gene/?term=856272 "YPR149W, NCE2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024838 856279 TPO3 http://www.ncbi.nlm.nih.gov/gene/?term=856279 YPR156C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024839 8562 DENR http://www.ncbi.nlm.nih.gov/gene/?term=8562 "DRP, DRP1, SMAP-3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024840 8562 DENR http://www.ncbi.nlm.nih.gov/gene/?term=8562 "DRP, DRP1, SMAP-3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024841 8562 DENR http://www.ncbi.nlm.nih.gov/gene/?term=8562 "DRP, DRP1, SMAP-3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024842 856321 QCR2 http://www.ncbi.nlm.nih.gov/gene/?term=856321 "YPR191W, COR2, UCR2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024843 856321 QCR2 http://www.ncbi.nlm.nih.gov/gene/?term=856321 "YPR191W, COR2, UCR2 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024844 856334 YPR204W http://www.ncbi.nlm.nih.gov/gene/?term=856334 YPR204W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024845 856335 YHL050C http://www.ncbi.nlm.nih.gov/gene/?term=856335 YHL050C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024846 856337 COS8 http://www.ncbi.nlm.nih.gov/gene/?term=856337 YHL048W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024847 856353 GUT1 http://www.ncbi.nlm.nih.gov/gene/?term=856353 YHL032C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024848 856354 GOS1 http://www.ncbi.nlm.nih.gov/gene/?term=856354 YHL031C mRNA Saccharomyces cerevisiae 23904265 Endoplasmic reticulum Yeast Confocal microscopy "We examined mRNA localization by confocal microscopy and found that 9 of 11 mSMPs tagged (ALG1, GOS1, ICE2, PEP12, PMT2, SUC2, SUR4, USE1, and YIP3) showed high levels of granule colocalization with ER (>70%; Figure 1 and Table 1), and 2 (NYV1 and SEC22) showed lower levels of ER localization (56%; Figure 1 and Table 1). A similar low level of ER localization was observed with two mRNAs that encode soluble SNAREs (SEC9 and SEC20) known to associate with the plasma and ER membranes (Figure 1 and Table 1). Of interest, some preference toward nER localization was observed with mSMPs such as PMT2, SUC2, SUR4, USE1, and YIP3, whereas in contrast, most of the mRNAs encoding SNAREs (e.g., GOS1, NYV1, PEP12, SEC9, and SEC22) demonstrated a preference for cER (Table 1). Data are collected from Table 1. " RLID00024849 856365 AIM17 http://www.ncbi.nlm.nih.gov/gene/?term=856365 "YHL021C, FMP12 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024850 856398 ERG11 http://www.ncbi.nlm.nih.gov/gene/?term=856398 "YHR007C, CYP51 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024851 8563 THOC5 http://www.ncbi.nlm.nih.gov/gene/?term=8563 "C22orf19, Fmip, PK1.3, fSAP79 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024852 8563 THOC5 http://www.ncbi.nlm.nih.gov/gene/?term=8563 "C22orf19, Fmip, PK1.3, fSAP79 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024853 856423 DAP2 http://www.ncbi.nlm.nih.gov/gene/?term=856423 "YHR028C, DPP2 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024854 856435 VMA10 http://www.ncbi.nlm.nih.gov/gene/?term=856435 "YHR039C-A, YHR039C-B " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024855 856438 NCP1 http://www.ncbi.nlm.nih.gov/gene/?term=856438 "YHR042W, CPR1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024856 856444 YHK8 http://www.ncbi.nlm.nih.gov/gene/?term=856444 YHR048W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024857 856448 COX6 http://www.ncbi.nlm.nih.gov/gene/?term=856448 YHR051W mRNA Saccharomyces cerevisiae 11027259 Ribosome Yeast Northern blot "In contrast, mRNAs encoding Cox6p, Cox5a, Aac1p, and Mir1p are found enriched in free cytoplasmic polysome fractions. Transcripts coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p are exclusively localized to mitochondrion-bound polysomes, while mRNAs encoding Cox6p, Cox5ap, Aac1p, and Mir1p are enriched in free cytoplasmic polysomes. The third family mRNAs were those predominantly associated with free cytoplasmic polysomes (Fig. ?(Fig.1A,1A, lanes F-P), such as COX6, COX5a, AAC1, and MIR1. " RLID00024858 856451 YHR054C http://www.ncbi.nlm.nih.gov/gene/?term=856451 YHR054C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024859 856475 PTC7 http://www.ncbi.nlm.nih.gov/gene/?term=856475 YHR076W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024860 856492 HXT4 http://www.ncbi.nlm.nih.gov/gene/?term=856492 "YHR092C, LGT1, RAG1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024861 856494 HXT1 http://www.ncbi.nlm.nih.gov/gene/?term=856494 "YHR094C, HOR4 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024862 856496 HXT5 http://www.ncbi.nlm.nih.gov/gene/?term=856496 YHR096C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024863 856499 TRA1 http://www.ncbi.nlm.nih.gov/gene/?term=856499 YHR099W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024864 8564 KMO http://www.ncbi.nlm.nih.gov/gene/?term=8564 dJ317G22.1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024865 8564 KMO http://www.ncbi.nlm.nih.gov/gene/?term=8564 dJ317G22.1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024866 856500 GEP4 http://www.ncbi.nlm.nih.gov/gene/?term=856500 YHR100C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024867 856517 TOM71 http://www.ncbi.nlm.nih.gov/gene/?term=856517 "YHR117W, TOM72 " mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024868 856533 ECM14 http://www.ncbi.nlm.nih.gov/gene/?term=856533 YHR132C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024869 856535 NSG1 http://www.ncbi.nlm.nih.gov/gene/?term=856535 YHR133C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024870 856541 SPS100 http://www.ncbi.nlm.nih.gov/gene/?term=856541 YHR139C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024871 856543 YHR140W http://www.ncbi.nlm.nih.gov/gene/?term=856543 YHR140W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024872 856555 PEX28 http://www.ncbi.nlm.nih.gov/gene/?term=856555 YHR150W mRNA Saccharomyces cerevisiae 26367800 Peroxisome Yeast RT-PCR Table 1: Predicted yeast mPP translation sites based on ER enrichment and imaging. A list of yeast peroxisomal genes was generated according to PeroxisomeDB 2.0. Data are collected from Table 1. RLID00024873 8565 YARS http://www.ncbi.nlm.nih.gov/gene/?term=8565 "CMTDIC, TYRRS, YRS, YTS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024874 8565 YARS http://www.ncbi.nlm.nih.gov/gene/?term=8565 "CMTDIC, TYRRS, YRS, YTS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024875 8565 YARS http://www.ncbi.nlm.nih.gov/gene/?term=8565 "CMTDIC, TYRRS, YRS, YTS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024876 856602 NVJ1 http://www.ncbi.nlm.nih.gov/gene/?term=856602 "YHR195W, VAB36 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024877 856606 AIM46 http://www.ncbi.nlm.nih.gov/gene/?term=856606 "YHR199C, FMP34 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024878 856628 YHR218W http://www.ncbi.nlm.nih.gov/gene/?term=856628 YHR218W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024879 856629 YHR219W http://www.ncbi.nlm.nih.gov/gene/?term=856629 YHR219W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024880 856630 YEL077C http://www.ncbi.nlm.nih.gov/gene/?term=856630 YEL077C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024881 856638 DLD3 http://www.ncbi.nlm.nih.gov/gene/?term=856638 YEL071W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024882 856658 AFG1 http://www.ncbi.nlm.nih.gov/gene/?term=856658 YEL052W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024883 856660 RML2 http://www.ncbi.nlm.nih.gov/gene/?term=856660 YEL050C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024884 856668 YEL043W http://www.ncbi.nlm.nih.gov/gene/?term=856668 YEL043W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024885 856669 GDA1 http://www.ncbi.nlm.nih.gov/gene/?term=856669 YEL042W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024886 856689 RIP1 http://www.ncbi.nlm.nih.gov/gene/?term=856689 YEL024W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024887 856690 YEL023C http://www.ncbi.nlm.nih.gov/gene/?term=856690 YEL023C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024888 856692 URA3 http://www.ncbi.nlm.nih.gov/gene/?term=856692 YEL021W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024889 856694 YEL020C http://www.ncbi.nlm.nih.gov/gene/?term=856694 YEL020C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024890 8566 PDXK http://www.ncbi.nlm.nih.gov/gene/?term=8566 "C21orf124, C21orf97, HEL-S-1a, PKH, PNK, PRED79 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024891 8566 PDXK http://www.ncbi.nlm.nih.gov/gene/?term=8566 "C21orf124, C21orf97, HEL-S-1a, PKH, PNK, PRED79 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024892 8566 PDXK http://www.ncbi.nlm.nih.gov/gene/?term=8566 "C21orf124, C21orf97, HEL-S-1a, PKH, PNK, PRED79 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024893 856716 WBP1 http://www.ncbi.nlm.nih.gov/gene/?term=856716 YEL002C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024894 856717 IRC22 http://www.ncbi.nlm.nih.gov/gene/?term=856717 YEL001C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024895 856719 NOP16 http://www.ncbi.nlm.nih.gov/gene/?term=856719 YER002W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024896 856726 SEC3 http://www.ncbi.nlm.nih.gov/gene/?term=856726 "YER008C, PSL1 " mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization "As SEC4 mRNA is asymmetrically distributed to the bud prior to nuclear division, similar to ASH1 mRNA, we examined the localization of other POL mRNAs by FISH (Fig. 1B). Endogenous mRNAs encoding the Cdc42 and Rho3 GTPases (31); the Sec1, Sro7, and Sro77 SNARE regulators (23,25); the Sec3 and Exo84 exocyst components (27); and Ypt1, a GTPase involved in ER-Golgi transport, localized at least in part to the buds of G2/M phase cells prior to nuclear division. This pattern was discerned in �0% of cells for each mRNA examined (Fig. 1B), indicating that these mRNAs were also exported from mother cells. Asymmetric POL mRNA localization correlates with the bud-specific pattern of protein localization seen during cell division. " RLID00024897 856726 SEC3 http://www.ncbi.nlm.nih.gov/gene/?term=856726 "YER008C, PSL1 " mRNA Saccharomyces cerevisiae 17339339 Cellular bud Yeast Fluorescence in situ hybridization Figure 1B: Endogenous mRNAs encoding bud-localized proteins also localize to the bud tip prior to nuclear division. WT yeast cells were treated as above and hybridized in situ with specific digoxigenin-labeled RNA antisense probes for different POL genes (as labeled). Representative small-budded (early G2/M) cells are shown. Data are collected from Figure 1B. RLID00024898 856733 HEM14 http://www.ncbi.nlm.nih.gov/gene/?term=856733 YER014W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024899 856745 YAT2 http://www.ncbi.nlm.nih.gov/gene/?term=856745 YER024W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024900 856788 FCY21 http://www.ncbi.nlm.nih.gov/gene/?term=856788 YER060W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024901 856789 FCY22 http://www.ncbi.nlm.nih.gov/gene/?term=856789 YER060W-A mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024902 8567 MADD http://www.ncbi.nlm.nih.gov/gene/?term=8567 "DENN, IG20, RAB3GEP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024903 8567 MADD http://www.ncbi.nlm.nih.gov/gene/?term=8567 "DENN, IG20, RAB3GEP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024904 856810 MRX1 http://www.ncbi.nlm.nih.gov/gene/?term=856810 YER077C mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024905 856813 AIM9 http://www.ncbi.nlm.nih.gov/gene/?term=856813 "YER080W, FMP29 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024906 856819 ILV1 http://www.ncbi.nlm.nih.gov/gene/?term=856819 "YER086W, ISO1 " mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024907 856884 COX15 http://www.ncbi.nlm.nih.gov/gene/?term=856884 YER141W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024908 856884 COX15 http://www.ncbi.nlm.nih.gov/gene/?term=856884 YER141W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024909 856893 SPI1 http://www.ncbi.nlm.nih.gov/gene/?term=856893 YER150W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024910 856898 OXA1 http://www.ncbi.nlm.nih.gov/gene/?term=856898 YER154W mRNA Saccharomyces cerevisiae 17108321 Mitochondrion Yeast RT-PCR "MRNA from 112 genes was studied, and the percentage of each mRNA associated with mitochondria-bound polysomes was between 0 and 57% (Supplementary Table S1 and Supplementary Figure S1). Data are collected from Table S1 - Biochemical analysis of the mRNA localization of 107 mRNAs coding for the subunits of seven mitochondrial complexes. " RLID00024911 856898 OXA1 http://www.ncbi.nlm.nih.gov/gene/?term=856898 YER154W mRNA Saccharomyces cerevisiae 17417645 Mitochondrion Yeast qRT-PCR "We previously demonstrated that SRO7 mRNA undergoes polarized transport, along with cortical ER, to the bud tip11. Thus, PEX3 mRNA localizes to the endoplasmic reticulum, as seen previously11, and Pex3 is functional after MS2L integration into the PEX3 locus. We observed typical tubular-punctate mitochondrial morphology with Oxa1-RFP19. " RLID00024912 856898 OXA1 http://www.ncbi.nlm.nih.gov/gene/?term=856898 YER154W mRNA Saccharomyces cerevisiae 19903887 Mitochondrion Yeast RT-PCR "We next examined the localization of POX1 mRNA in cells expressing Oxa1-RFP, a mitochondrial marker, and found that 44% of POX1 granules colocalized with mitochondria (Table S4). In contrast, 82% of OXA1 mRNA granules [which localize to mitochondria (13, 14)] colocalized with Oxa1-RFP. The large number of cells having POX1 mRNA localized to mitochondria might stem from the fact that Oxa1-RFP-labeled mitochondria fill a substantial volume of the cell. " RLID00024913 856898 OXA1 http://www.ncbi.nlm.nih.gov/gene/?term=856898 YER154W mRNA Saccharomyces cerevisiae 21705432 Mitochondrion Yeast Microarray|RT-PCR "Out of 24 tagged mMPs, we found that the ATM1, ATP2, ATP10, CYB2, COX10,MDM10, and OXA1 mRNA granules exhibited very high levels of colocalization with mitochondria (e.g., >80%), while the CBS1, CYC3, and FIS1 mRNAs demonstrated low levels of colocalization (i.e., �4%) on glucose-containing medium (Fig. 1A; Table 1). Taken together, the data suggest that the 3�UTR is necessary for ATP2 and OXA1 mRNA localization to mitochondria (Table 3). " RLID00024914 856898 OXA1 http://www.ncbi.nlm.nih.gov/gene/?term=856898 YER154W mRNA Saccharomyces cerevisiae 21705432 Endoplasmic reticulum Yeast Microarray|RT-PCR TABLE 2. OXA1 and ATP2 mRNA localization to mitochondria and ER. Data are collected from Table 2. RLID00024915 8568 RRP1 http://www.ncbi.nlm.nih.gov/gene/?term=8568 "D21S2056E, NNP-1, NOP52A, RRP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024916 856913 DNF1 http://www.ncbi.nlm.nih.gov/gene/?term=856913 YER166W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024917 856925 PDA1 http://www.ncbi.nlm.nih.gov/gene/?term=856925 YER178W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024918 856931 FMP10 http://www.ncbi.nlm.nih.gov/gene/?term=856931 YER182W mRNA Saccharomyces cerevisiae 11818335 Mitochondrion Yeast Microarray Genome-wide analysis of mRNAs targeted to yeast mitochondria: all data have been shown in supplementary file : list of the 467 ORFs found to have a mitochondrial localization of mRNA (MLR) >80 in this study. RLID00024919 8569 MKNK1 http://www.ncbi.nlm.nih.gov/gene/?term=8569 MNK1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024920 8569 MKNK1 http://www.ncbi.nlm.nih.gov/gene/?term=8569 MNK1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024921 8569 MKNK1 http://www.ncbi.nlm.nih.gov/gene/?term=8569 MNK1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024922 8570 KHSRP http://www.ncbi.nlm.nih.gov/gene/?term=8570 "FBP2, FUBP2, KSRP " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024923 8570 KHSRP http://www.ncbi.nlm.nih.gov/gene/?term=8570 "FBP2, FUBP2, KSRP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024924 8570 KHSRP http://www.ncbi.nlm.nih.gov/gene/?term=8570 "FBP2, FUBP2, KSRP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024925 8573 CASK http://www.ncbi.nlm.nih.gov/gene/?term=8573 "CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024926 8573 CASK http://www.ncbi.nlm.nih.gov/gene/?term=8573 "CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024927 8574 AKR7A2 http://www.ncbi.nlm.nih.gov/gene/?term=8574 "AFAR, AFAR1, AFB1-AR1, AKR7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024928 8574 AKR7A2 http://www.ncbi.nlm.nih.gov/gene/?term=8574 "AFAR, AFAR1, AFB1-AR1, AKR7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024929 8576 STK16 http://www.ncbi.nlm.nih.gov/gene/?term=8576 "KRCT, MPSK, PKL12, TSF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024930 8577 TMEFF1 http://www.ncbi.nlm.nih.gov/gene/?term=8577 "C9orf2, CT120.1, H7365, TR-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024931 8578 SCARF1 http://www.ncbi.nlm.nih.gov/gene/?term=8578 "SREC, SREC-I, SREC1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024932 8578 SCARF1 http://www.ncbi.nlm.nih.gov/gene/?term=8578 "SREC, SREC-I, SREC1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024933 857 CAV1 http://www.ncbi.nlm.nih.gov/gene/?term=857 "BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024934 858 CAV2 http://www.ncbi.nlm.nih.gov/gene/?term=858 CAV mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024935 858 CAV2 http://www.ncbi.nlm.nih.gov/gene/?term=858 CAV mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024936 8602 NOP14 http://www.ncbi.nlm.nih.gov/gene/?term=8602 "C4orf9, NOL14, RES4-25, RES425, UTP2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024937 8602 NOP14 http://www.ncbi.nlm.nih.gov/gene/?term=8602 "C4orf9, NOL14, RES4-25, RES425, UTP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024938 8603 FAM193A http://www.ncbi.nlm.nih.gov/gene/?term=8603 "C4orf8, RES4-22 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024939 8607 RUVBL1 http://www.ncbi.nlm.nih.gov/gene/?term=8607 "ECP-54, ECP54, INO80H, NMP 238, NMP238, PONTIN, Pontin52, RVB1, TIH1, TIP49, TIP49A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024940 8609 KLF7 http://www.ncbi.nlm.nih.gov/gene/?term=8609 UKLF mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024941 860 RUNX2 http://www.ncbi.nlm.nih.gov/gene/?term=860 "AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024942 8611 PLPP1 http://www.ncbi.nlm.nih.gov/gene/?term=8611 "LLP1a, LPP1, PAP-2a, PAP2, PPAP2A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024943 8612 PLPP2 http://www.ncbi.nlm.nih.gov/gene/?term=8612 "LPP2, PAP-2c, PAP2-g, PPAP2C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024944 8614 STC2 http://www.ncbi.nlm.nih.gov/gene/?term=8614 "STC-2, STCRP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024945 8614 STC2 http://www.ncbi.nlm.nih.gov/gene/?term=8614 "STC-2, STCRP " mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00024946 8614 STC2 http://www.ncbi.nlm.nih.gov/gene/?term=8614 "STC-2, STCRP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024947 8615 USO1 http://www.ncbi.nlm.nih.gov/gene/?term=8615 "P115, TAP, VDP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024948 8615 USO1 http://www.ncbi.nlm.nih.gov/gene/?term=8615 "P115, TAP, VDP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024949 8615 USO1 http://www.ncbi.nlm.nih.gov/gene/?term=8615 "P115, TAP, VDP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024950 861 RUNX1 http://www.ncbi.nlm.nih.gov/gene/?term=861 "AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024951 8620 NPFF http://www.ncbi.nlm.nih.gov/gene/?term=8620 FMRFAL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024952 8621 CDK13 http://www.ncbi.nlm.nih.gov/gene/?term=8621 "CDC2L, CDC2L5, CHED, hCDK13 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024953 8621 CDK13 http://www.ncbi.nlm.nih.gov/gene/?term=8621 "CDC2L, CDC2L5, CHED, hCDK13 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024954 8623 ASMTL http://www.ncbi.nlm.nih.gov/gene/?term=8623 "ASMTLX, ASMTLY, ASTML " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024955 8624 PSMG1 http://www.ncbi.nlm.nih.gov/gene/?term=8624 "C21LRP, DSCR2, LRPC21, PAC-1, PAC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024956 8624 PSMG1 http://www.ncbi.nlm.nih.gov/gene/?term=8624 "C21LRP, DSCR2, LRPC21, PAC-1, PAC1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024957 8624 PSMG1 http://www.ncbi.nlm.nih.gov/gene/?term=8624 "C21LRP, DSCR2, LRPC21, PAC-1, PAC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024958 8625 RFXANK http://www.ncbi.nlm.nih.gov/gene/?term=8625 "ANKRA1, BLS, F14150_1, RFX-B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024959 8625 RFXANK http://www.ncbi.nlm.nih.gov/gene/?term=8625 "ANKRA1, BLS, F14150_1, RFX-B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024960 8629 JRK http://www.ncbi.nlm.nih.gov/gene/?term=8629 "JH8, jerky " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024961 8629 JRK http://www.ncbi.nlm.nih.gov/gene/?term=8629 "JH8, jerky " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024962 862 RUNX1T1 http://www.ncbi.nlm.nih.gov/gene/?term=862 "AML1-MTG8, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024963 8630 HSD17B6 http://www.ncbi.nlm.nih.gov/gene/?term=8630 "HSE, RODH, SDR9C6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024964 8634 RTCA http://www.ncbi.nlm.nih.gov/gene/?term=8634 "RPC, RTC1, RTCD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024965 8634 RTCA http://www.ncbi.nlm.nih.gov/gene/?term=8634 "RPC, RTC1, RTCD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024966 8635 RNASET2 http://www.ncbi.nlm.nih.gov/gene/?term=8635 "RNASE6PL, bA514O12.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024967 8635 RNASET2 http://www.ncbi.nlm.nih.gov/gene/?term=8635 "RNASE6PL, bA514O12.3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024968 8635 RNASET2 http://www.ncbi.nlm.nih.gov/gene/?term=8635 "RNASE6PL, bA514O12.3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024969 8636 SSNA1 http://www.ncbi.nlm.nih.gov/gene/?term=8636 "N14, NA-14, NA14 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024970 8639 AOC3 http://www.ncbi.nlm.nih.gov/gene/?term=8639 "HPAO, SSAO, VAP-1, VAP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024971 8644 AKR1C3 http://www.ncbi.nlm.nih.gov/gene/?term=8644 "DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024972 8644 AKR1C3 http://www.ncbi.nlm.nih.gov/gene/?term=8644 "DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024973 8648 NCOA1 http://www.ncbi.nlm.nih.gov/gene/?term=8648 "F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024974 8649 LAMTOR3 http://www.ncbi.nlm.nih.gov/gene/?term=8649 "MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024975 8649 LAMTOR3 http://www.ncbi.nlm.nih.gov/gene/?term=8649 "MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024976 8649 LAMTOR3 http://www.ncbi.nlm.nih.gov/gene/?term=8649 "MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024977 8650 NUMB http://www.ncbi.nlm.nih.gov/gene/?term=8650 "C14orf41, S171, c14_5527 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024978 8650 NUMB http://www.ncbi.nlm.nih.gov/gene/?term=8650 "C14orf41, S171, c14_5527 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024979 8651 SOCS1 http://www.ncbi.nlm.nih.gov/gene/?term=8651 "CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024980 8653 DDX3Y http://www.ncbi.nlm.nih.gov/gene/?term=8653 DBY mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024981 8653 DDX3Y http://www.ncbi.nlm.nih.gov/gene/?term=8653 DBY mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024982 8653 DDX3Y http://www.ncbi.nlm.nih.gov/gene/?term=8653 DBY mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024983 8655 DYNLL1 http://www.ncbi.nlm.nih.gov/gene/?term=8655 "DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024984 8655 DYNLL1 http://www.ncbi.nlm.nih.gov/gene/?term=8655 "DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024985 8655 DYNLL1 http://www.ncbi.nlm.nih.gov/gene/?term=8655 "DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024986 865 CBFB http://www.ncbi.nlm.nih.gov/gene/?term=865 PEBP2B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024987 865 CBFB http://www.ncbi.nlm.nih.gov/gene/?term=865 PEBP2B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024988 8661 EIF3A http://www.ncbi.nlm.nih.gov/gene/?term=8661 "EIF3, EIF3S10, P167, TIF32, eIF3-p170, eIF3-theta, p180, p185 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024989 8661 EIF3A http://www.ncbi.nlm.nih.gov/gene/?term=8661 "EIF3, EIF3S10, P167, TIF32, eIF3-p170, eIF3-theta, p180, p185 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00024990 8662 EIF3B http://www.ncbi.nlm.nih.gov/gene/?term=8662 "EIF3-ETA, EIF3-P110, EIF3-P116, EIF3S9, PRT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024991 8663 EIF3C http://www.ncbi.nlm.nih.gov/gene/?term=8663 "EIF3CL, EIF3S8, eIF3-p110 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024992 8664 EIF3D http://www.ncbi.nlm.nih.gov/gene/?term=8664 "EIF3S7, eIF3-p66, eIF3-zeta " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024993 8666 EIF3G http://www.ncbi.nlm.nih.gov/gene/?term=8666 "EIF3-P42, EIF3S4, eIF3-delta, eIF3-p44 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024994 8666 EIF3G http://www.ncbi.nlm.nih.gov/gene/?term=8666 "EIF3-P42, EIF3S4, eIF3-delta, eIF3-p44 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024995 8666 EIF3G http://www.ncbi.nlm.nih.gov/gene/?term=8666 "EIF3-P42, EIF3S4, eIF3-delta, eIF3-p44 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00024996 8667 EIF3H http://www.ncbi.nlm.nih.gov/gene/?term=8667 "EIF3S3, eIF3-gamma, eIF3-p40 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024997 8668 EIF3I http://www.ncbi.nlm.nih.gov/gene/?term=8668 "EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00024998 8668 EIF3I http://www.ncbi.nlm.nih.gov/gene/?term=8668 "EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00024999 8668 EIF3I http://www.ncbi.nlm.nih.gov/gene/?term=8668 "EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025000 8668 EIF3I http://www.ncbi.nlm.nih.gov/gene/?term=8668 "EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025001 8668 EIF3I http://www.ncbi.nlm.nih.gov/gene/?term=8668 "EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025002 8669 EIF3J http://www.ncbi.nlm.nih.gov/gene/?term=8669 "EIF3S1, eIF3-alpha, eIF3-p35 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025003 8669 EIF3J http://www.ncbi.nlm.nih.gov/gene/?term=8669 "EIF3S1, eIF3-alpha, eIF3-p35 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025004 8669 EIF3J http://www.ncbi.nlm.nih.gov/gene/?term=8669 "EIF3S1, eIF3-alpha, eIF3-p35 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025005 8672 EIF4G3 http://www.ncbi.nlm.nih.gov/gene/?term=8672 "eIF-4G 3, eIF4G 3, eIF4GII " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025006 8673 VAMP8 http://www.ncbi.nlm.nih.gov/gene/?term=8673 "EDB, VAMP-8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025007 8674055 mgl http://www.ncbi.nlm.nih.gov/gene/?term=8674055 "Dmel_CG42611, CG12139, CG12654, CG15316, CG34339, CG34352, CG42611, CT7830, Dm CG34352, Dmel\CG42611, Dmel_CG12139, Dmel_CG12654, Dmel_CG34339, Dmel_CG34352, LDLR, SOSIE, anon-WO0140519.108 " mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00025008 8674 VAMP4 http://www.ncbi.nlm.nih.gov/gene/?term=8674 "VAMP-4, VAMP24 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025009 8675 STX16 http://www.ncbi.nlm.nih.gov/gene/?term=8675 SYN16 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025010 8676 STX11 http://www.ncbi.nlm.nih.gov/gene/?term=8676 "FHL4, HLH4, HPLH4 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025011 8676 STX11 http://www.ncbi.nlm.nih.gov/gene/?term=8676 "FHL4, HLH4, HPLH4 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025012 8677 STX10 http://www.ncbi.nlm.nih.gov/gene/?term=8677 "SYN10, hsyn10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025013 8678 BECN1 http://www.ncbi.nlm.nih.gov/gene/?term=8678 "ATG6, VPS30, beclin1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025014 867 CBL http://www.ncbi.nlm.nih.gov/gene/?term=867 "C-CBL2, FRA11B, NSLL, RNF55, CBL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025015 867 CBL http://www.ncbi.nlm.nih.gov/gene/?term=867 "C-CBL2, FRA11B, NSLL, RNF55, CBL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025016 867 CBL http://www.ncbi.nlm.nih.gov/gene/?term=867 "C-CBL2, FRA11B, NSLL, RNF55, CBL " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025017 867 CBL http://www.ncbi.nlm.nih.gov/gene/?term=867 "C-CBL2, FRA11B, NSLL, RNF55, CBL " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025018 867 CBL http://www.ncbi.nlm.nih.gov/gene/?term=867 "C-CBL, CBL2, FRA11B, NSLL, RNF55 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025019 8682 PEA15 http://www.ncbi.nlm.nih.gov/gene/?term=8682 "HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025020 8682 PEA15 http://www.ncbi.nlm.nih.gov/gene/?term=8682 "HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025021 8682 PEA15 http://www.ncbi.nlm.nih.gov/gene/?term=8682 "HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025022 8683 SRSF9 http://www.ncbi.nlm.nih.gov/gene/?term=8683 "SFRS9, SRp30c " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025023 8683 SRSF9 http://www.ncbi.nlm.nih.gov/gene/?term=8683 "SFRS9, SRp30c " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025024 868 CBLB http://www.ncbi.nlm.nih.gov/gene/?term=868 "Cbl-b, Nbla00127, RNF56 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025025 8690 JRKL http://www.ncbi.nlm.nih.gov/gene/?term=8690 HHMJG mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025026 8692 HYAL2 http://www.ncbi.nlm.nih.gov/gene/?term=8692 LUCA2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025027 8694 DGAT1 http://www.ncbi.nlm.nih.gov/gene/?term=8694 "ARAT, ARGP1, DGAT, DIAR7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025028 8694 DGAT1 http://www.ncbi.nlm.nih.gov/gene/?term=8694 "ARAT, ARGP1, DGAT, DIAR7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025029 8697 CDC23 http://www.ncbi.nlm.nih.gov/gene/?term=8697 "ANAPC8, APC8, CUT23 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025030 86 ACTL6A http://www.ncbi.nlm.nih.gov/gene/?term=86 "ACTL6, ARPN-BETA, Arp4, BAF53A, INO80K " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025031 86 ACTL6A http://www.ncbi.nlm.nih.gov/gene/?term=86 "ACTL6, ARPN-BETA, Arp4, BAF53A, INO80K " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025032 8702 B4GALT4 http://www.ncbi.nlm.nih.gov/gene/?term=8702 "B4Gal-T4, beta4Gal-T4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025033 8703 B4GALT3 http://www.ncbi.nlm.nih.gov/gene/?term=8703 beta4Gal-T3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025034 8704 B4GALT2 http://www.ncbi.nlm.nih.gov/gene/?term=8704 "B4Gal-T2, B4Gal-T3, beta4Gal-T2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025035 8705 B3GALT4 http://www.ncbi.nlm.nih.gov/gene/?term=8705 "BETA3GALT4, GALT2, GALT4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025036 8714 ABCC3 http://www.ncbi.nlm.nih.gov/gene/?term=8714 "ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025037 87178 PNPT1 http://www.ncbi.nlm.nih.gov/gene/?term=87178 "COXPD13, DFNB70, OLD35, PNPASE, old-35 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025038 87178 PNPT1 http://www.ncbi.nlm.nih.gov/gene/?term=87178 "COXPD13, DFNB70, OLD35, PNPASE, old-35 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025039 87178 PNPT1 http://www.ncbi.nlm.nih.gov/gene/?term=87178 "COXPD13, DFNB70, OLD35, PNPASE, old-35 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025040 8717 TRADD http://www.ncbi.nlm.nih.gov/gene/?term=8717 Hs.89862 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025041 8717 TRADD http://www.ncbi.nlm.nih.gov/gene/?term=8717 Hs.89862 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025042 8718 TNFRSF25 http://www.ncbi.nlm.nih.gov/gene/?term=8718 "APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025043 871 SERPINH1 http://www.ncbi.nlm.nih.gov/gene/?term=871 "AsTP3, CBP1, CBP2, HSP47, OI10, PIG14, PPROM, RA-A47, SERPINH2, gp46 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025044 871 SERPINH1 http://www.ncbi.nlm.nih.gov/gene/?term=871 "AsTP3, CBP1, CBP2, HSP47, OI10, PIG14, PPROM, RA-A47, SERPINH2, gp46 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025045 8720 MBTPS1 http://www.ncbi.nlm.nih.gov/gene/?term=8720 "PCSK8, S1P, SKI-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025046 8720 MBTPS1 http://www.ncbi.nlm.nih.gov/gene/?term=8720 "PCSK8, S1P, SKI-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025047 8721 EDF1 http://www.ncbi.nlm.nih.gov/gene/?term=8721 "CFAP280, EDF-1, MBF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025048 8723 SNX4 http://www.ncbi.nlm.nih.gov/gene/?term=8723 ATG24B mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025049 8723 SNX4 http://www.ncbi.nlm.nih.gov/gene/?term=8723 ATG24B mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025050 8723 SNX4 http://www.ncbi.nlm.nih.gov/gene/?term=8723 ATG24B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025051 8724 SNX3 http://www.ncbi.nlm.nih.gov/gene/?term=8724 "Grd19, MCOPS8, SDP3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025052 8725 URI1 http://www.ncbi.nlm.nih.gov/gene/?term=8725 "C19orf2, NNX3, PPP1R19, RMP, URI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025053 8726 EED http://www.ncbi.nlm.nih.gov/gene/?term=8726 "HEED, WAIT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025054 8727 CTNNAL1 http://www.ncbi.nlm.nih.gov/gene/?term=8727 "ACRP, CLLP, alpha-CATU " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025055 8727 CTNNAL1 http://www.ncbi.nlm.nih.gov/gene/?term=8727 "ACRP, CLLP, alpha-CATU " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025056 8727 CTNNAL1 http://www.ncbi.nlm.nih.gov/gene/?term=8727 "ACRP, CLLP, alpha-CATU " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025057 8729 GBF1 http://www.ncbi.nlm.nih.gov/gene/?term=8729 ARF1GEF mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025058 8729 GBF1 http://www.ncbi.nlm.nih.gov/gene/?term=8729 ARF1GEF mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025059 8731 RNMT http://www.ncbi.nlm.nih.gov/gene/?term=8731 "CMT1, CMT1c, MET, Met, RG7MT1, cm1p, hCMT1, hMet " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025060 8731 RNMT http://www.ncbi.nlm.nih.gov/gene/?term=8731 "CMT1, CMT1c, MET, Met, RG7MT1, cm1p, hCMT1, hMet " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025061 8733 GPAA1 http://www.ncbi.nlm.nih.gov/gene/?term=8733 "GAA1, hGAA1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025062 8737 RIPK1 http://www.ncbi.nlm.nih.gov/gene/?term=8737 "RIP, RIP-1, RIP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025063 8737 RIPK1 http://www.ncbi.nlm.nih.gov/gene/?term=8737 "RIP, RIP-1, RIP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025064 8738 CRADD http://www.ncbi.nlm.nih.gov/gene/?term=8738 "MRT34, RAIDD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025065 8738 CRADD http://www.ncbi.nlm.nih.gov/gene/?term=8738 "MRT34, RAIDD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025066 873 CBR1 http://www.ncbi.nlm.nih.gov/gene/?term=873 "CBR, SDR21C1, hCBR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025067 873 CBR1 http://www.ncbi.nlm.nih.gov/gene/?term=873 "CBR, SDR21C1, hCBR1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025068 873 CBR1 http://www.ncbi.nlm.nih.gov/gene/?term=873 "CBR, SDR21C1, hCBR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025069 8741 TNFSF13 http://www.ncbi.nlm.nih.gov/gene/?term=8741 "APRIL, CD256, TALL-2, TALL2, TNLG7B, TRDL-1, UNQ383/PRO715, ZTNF2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025070 8743 TNFSF10 http://www.ncbi.nlm.nih.gov/gene/?term=8743 "APO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025071 8744 TNFSF9 http://www.ncbi.nlm.nih.gov/gene/?term=8744 "4-1BB-L, CD137L, TNLG5A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025072 8745 ADAM23 http://www.ncbi.nlm.nih.gov/gene/?term=8745 "MDC-3, MDC3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025073 8751 ADAM15 http://www.ncbi.nlm.nih.gov/gene/?term=8751 MDC15 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025074 8751 ADAM15 http://www.ncbi.nlm.nih.gov/gene/?term=8751 MDC15 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025075 8754 ADAM9 http://www.ncbi.nlm.nih.gov/gene/?term=8754 "CORD9, MCMP, MDC9, Mltng " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025076 8754 ADAM9 http://www.ncbi.nlm.nih.gov/gene/?term=8754 "CORD9, MCMP, MDC9, Mltng " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025077 8754 ADAM9 http://www.ncbi.nlm.nih.gov/gene/?term=8754 "CORD9, MCMP, MDC9, Mltng " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025078 875 CBS http://www.ncbi.nlm.nih.gov/gene/?term=875 HIP4 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025079 875 CBS http://www.ncbi.nlm.nih.gov/gene/?term=875 HIP4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025080 8761 PABPC4 http://www.ncbi.nlm.nih.gov/gene/?term=8761 "APP-1, APP1, PABP4, iPABP " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025081 8763 CD164 http://www.ncbi.nlm.nih.gov/gene/?term=8763 "DFNA66, MGC-24, MUC-24, endolyn " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025082 8763 CD164 http://www.ncbi.nlm.nih.gov/gene/?term=8763 "DFNA66, MGC-24, MUC-24, endolyn " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025083 8764 TNFRSF14 http://www.ncbi.nlm.nih.gov/gene/?term=8764 "ATAR, CD270, HVEA, HVEM, LIGHTR, TR2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025084 8766 RAB11A http://www.ncbi.nlm.nih.gov/gene/?term=8766 YL8 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025085 8766 RAB11A http://www.ncbi.nlm.nih.gov/gene/?term=8766 YL8 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025086 8772 FADD http://www.ncbi.nlm.nih.gov/gene/?term=8772 "GIG3, MORT1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025087 8772 FADD http://www.ncbi.nlm.nih.gov/gene/?term=8772 "GIG3, MORT1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025088 8772 FADD http://www.ncbi.nlm.nih.gov/gene/?term=8772 "GIG3, MORT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025089 8773 SNAP23 http://www.ncbi.nlm.nih.gov/gene/?term=8773 "HsT17016, SNAP-23A, SNAP23B, SNAP23 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025090 8773 SNAP23 http://www.ncbi.nlm.nih.gov/gene/?term=8773 "HsT17016, SNAP-23A, SNAP23B, SNAP23 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025091 8773 SNAP23 http://www.ncbi.nlm.nih.gov/gene/?term=8773 "HsT17016, SNAP-23, SNAP23A, SNAP23B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025092 8774 NAPG http://www.ncbi.nlm.nih.gov/gene/?term=8774 GAMMASNAP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025093 8775 NAPA http://www.ncbi.nlm.nih.gov/gene/?term=8775 SNAPA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025094 8775 NAPA http://www.ncbi.nlm.nih.gov/gene/?term=8775 SNAPA mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025095 8776 MTMR1 http://www.ncbi.nlm.nih.gov/gene/?term=8776 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025096 8780 RIOK3 http://www.ncbi.nlm.nih.gov/gene/?term=8780 SUDD mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025097 8780 RIOK3 http://www.ncbi.nlm.nih.gov/gene/?term=8780 SUDD mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025098 8784 TNFRSF18 http://www.ncbi.nlm.nih.gov/gene/?term=8784 "AITR, CD357, GITR, GITR-D " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025099 8788 DLK1 http://www.ncbi.nlm.nih.gov/gene/?term=8788 "DLK, DLK-1, Delta1, FA1, PREF1, Pref-1, ZOG, pG2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025100 8790 FPGT http://www.ncbi.nlm.nih.gov/gene/?term=8790 GFPP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025101 8790 FPGT http://www.ncbi.nlm.nih.gov/gene/?term=8790 GFPP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025102 8793 TNFRSF10D http://www.ncbi.nlm.nih.gov/gene/?term=8793 "CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025103 8793 TNFRSF10D http://www.ncbi.nlm.nih.gov/gene/?term=8793 "CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025104 8795 TNFRSF10B http://www.ncbi.nlm.nih.gov/gene/?term=8795 "CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025105 8795 TNFRSF10B http://www.ncbi.nlm.nih.gov/gene/?term=8795 "CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025106 8795 TNFRSF10B http://www.ncbi.nlm.nih.gov/gene/?term=8795 "CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025107 8795 TNFRSF10B http://www.ncbi.nlm.nih.gov/gene/?term=8795 "CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025108 8796 SCEL http://www.ncbi.nlm.nih.gov/gene/?term=8796 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025109 8797 TNFRSF10A http://www.ncbi.nlm.nih.gov/gene/?term=8797 "APO2, CD261, DR4, TRAILR-1, TRAILR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025110 8798 DYRK4 http://www.ncbi.nlm.nih.gov/gene/?term=8798 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025111 8798 DYRK4 http://www.ncbi.nlm.nih.gov/gene/?term=8798 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025112 8799 PEX11B http://www.ncbi.nlm.nih.gov/gene/?term=8799 "PEX11-BETA, PEX14B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025113 87 ACTN1 http://www.ncbi.nlm.nih.gov/gene/?term=87 BDPLT15 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025114 8801 SUCLG2 http://www.ncbi.nlm.nih.gov/gene/?term=8801 GBETA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025115 8801 SUCLG2 http://www.ncbi.nlm.nih.gov/gene/?term=8801 GBETA mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025116 8802 SUCLG1 http://www.ncbi.nlm.nih.gov/gene/?term=8802 "GALPHA, MTDPS9, SUCLA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025117 8803 SUCLA2 http://www.ncbi.nlm.nih.gov/gene/?term=8803 "A-BETA, MTDPS5, SCS-betaA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025118 8804 CREG1 http://www.ncbi.nlm.nih.gov/gene/?term=8804 CREG mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025119 8804 CREG1 http://www.ncbi.nlm.nih.gov/gene/?term=8804 CREG mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025120 8804 CREG1 http://www.ncbi.nlm.nih.gov/gene/?term=8804 CREG mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025121 8805 TRIM24 http://www.ncbi.nlm.nih.gov/gene/?term=8805 "PTC6, RNF82, TF1A, TIF1, TIF1A, TIF1ALPHA, hTIF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025122 8809 IL18R1 http://www.ncbi.nlm.nih.gov/gene/?term=8809 "CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025123 8809 IL18R1 http://www.ncbi.nlm.nih.gov/gene/?term=8809 "CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025124 8809 IL18R1 http://www.ncbi.nlm.nih.gov/gene/?term=8809 "CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025125 8813 DPM1 http://www.ncbi.nlm.nih.gov/gene/?term=8813 "CDGIE, MPDS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025126 8813 DPM1 http://www.ncbi.nlm.nih.gov/gene/?term=8813 "CDGIE, MPDS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025127 8815 BANF1 http://www.ncbi.nlm.nih.gov/gene/?term=8815 "BAF, BCRP1, D14S1460, NGPS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025128 8815 BANF1 http://www.ncbi.nlm.nih.gov/gene/?term=8815 "BAF, BCRP1, D14S1460, NGPS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025129 8815 BANF1 http://www.ncbi.nlm.nih.gov/gene/?term=8815 "BAF, BCRP1, D14S1460, NGPS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025130 8816 DCAF5 http://www.ncbi.nlm.nih.gov/gene/?term=8816 "BCRG2, BCRP2, D14S1461E, WDR22 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025131 8818 DPM2 http://www.ncbi.nlm.nih.gov/gene/?term=8818 CDG1U mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025132 8818 DPM2 http://www.ncbi.nlm.nih.gov/gene/?term=8818 CDG1U mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025133 8818 DPM2 http://www.ncbi.nlm.nih.gov/gene/?term=8818 CDG1U mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025134 8819 SAP30 http://www.ncbi.nlm.nih.gov/gene/?term=8819 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025135 8824 CES2 http://www.ncbi.nlm.nih.gov/gene/?term=8824 "CE-2, CES2A1, PCE-2, iCE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025136 8826 IQGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=8826 "HUMORFA01, SAR1, p195 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025137 8826 IQGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=8826 "HUMORFA01, SAR1, p195 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025138 8826 IQGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=8826 "HUMORFA01, SAR1, p195 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025139 8829 NRP1 http://www.ncbi.nlm.nih.gov/gene/?term=8829 "BDCA4, CD304, NP1, NRP, VEGF165R " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025140 8833 GMPS http://www.ncbi.nlm.nih.gov/gene/?term=8833 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025141 8833 GMPS http://www.ncbi.nlm.nih.gov/gene/?term=8833 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025142 8833 GMPS http://www.ncbi.nlm.nih.gov/gene/?term=8833 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025143 8834 TMEM11 http://www.ncbi.nlm.nih.gov/gene/?term=8834 "C17orf35, PM1, PMI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025144 8834 TMEM11 http://www.ncbi.nlm.nih.gov/gene/?term=8834 "C17orf35, PM1, PMI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025145 8835 SOCS2 http://www.ncbi.nlm.nih.gov/gene/?term=8835 "CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025146 8836 GGH http://www.ncbi.nlm.nih.gov/gene/?term=8836 GH mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025147 8836 GGH http://www.ncbi.nlm.nih.gov/gene/?term=8836 GH mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025148 8836 GGH http://www.ncbi.nlm.nih.gov/gene/?term=8836 GH mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025149 8837 CFLAR http://www.ncbi.nlm.nih.gov/gene/?term=8837 "CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025150 883 KYAT1 http://www.ncbi.nlm.nih.gov/gene/?term=883 "GTK, KAT1, KATI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025151 8841 HDAC3 http://www.ncbi.nlm.nih.gov/gene/?term=8841 "HD3, RPD3, RPD3-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025152 8841 HDAC3 http://www.ncbi.nlm.nih.gov/gene/?term=8841 "HD3, RPD3, RPD3-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025153 8841 HDAC3 http://www.ncbi.nlm.nih.gov/gene/?term=8841 "HD3, RPD3, RPD3-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025154 8841 HDAC3 http://www.ncbi.nlm.nih.gov/gene/?term=8841 "HD3, RPD3, RPD3-2 " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00025155 8842 PROM1 http://www.ncbi.nlm.nih.gov/gene/?term=8842 "AC133, CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025156 8846 ALKBH1 http://www.ncbi.nlm.nih.gov/gene/?term=8846 "ABH, ABH1, ALKBH, alkB, hABH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025157 8846 ALKBH1 http://www.ncbi.nlm.nih.gov/gene/?term=8846 "ABH, ABH1, ALKBH, alkB, hABH " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025158 8847 DLEU2 http://www.ncbi.nlm.nih.gov/gene/?term=8847 "1B4, BCMSUN, DLB2, LEU2, LINC00022, MIR15AHG, NCRNA00022, RFP2OS, TRIM13OS " lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025159 8848 TSC22D1 http://www.ncbi.nlm.nih.gov/gene/?term=8848 "Ptg-2, TGFB1I4, TSC22 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025160 8848 TSC22D1 http://www.ncbi.nlm.nih.gov/gene/?term=8848 "Ptg-2, TGFB1I4, TSC22 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025161 8848 TSC22D1 http://www.ncbi.nlm.nih.gov/gene/?term=8848 "Ptg-2, TGFB1I4, TSC22 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025162 8850 KAT2B http://www.ncbi.nlm.nih.gov/gene/?term=8850 "CAF, P/CAF, PCAF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025163 8853 ASAP2 http://www.ncbi.nlm.nih.gov/gene/?term=8853 "AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025164 8853 ASAP2 http://www.ncbi.nlm.nih.gov/gene/?term=8853 "AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025165 8854 ALDH1A2 http://www.ncbi.nlm.nih.gov/gene/?term=8854 "RALDH(II), RALDH2, RALDH2-T " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025166 8854 ALDH1A2 http://www.ncbi.nlm.nih.gov/gene/?term=8854 "RALDH(II), RALDH2, RALDH2-T " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025167 8857 FCGBP http://www.ncbi.nlm.nih.gov/gene/?term=8857 FC(GAMMA)BP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025168 8861 LDB1 http://www.ncbi.nlm.nih.gov/gene/?term=8861 "CLIM-2, CLIM2, LDB-1, NLI " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025169 8864 PER2 http://www.ncbi.nlm.nih.gov/gene/?term=8864 "FASPS, FASPS1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025170 8864 PER2 http://www.ncbi.nlm.nih.gov/gene/?term=8864 "FASPS, FASPS1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025171 8867 SYNJ1 http://www.ncbi.nlm.nih.gov/gene/?term=8867 "INPP5G, PARK20 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025172 8869 ST3GAL5 http://www.ncbi.nlm.nih.gov/gene/?term=8869 "SATI, SIAT9, SIATGM3S, ST3GalV " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025173 8869 ST3GAL5 http://www.ncbi.nlm.nih.gov/gene/?term=8869 "SATI, SIAT9, SIATGM3S, ST3GalV " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025174 8870 IER3 http://www.ncbi.nlm.nih.gov/gene/?term=8870 "DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025175 8870 IER3 http://www.ncbi.nlm.nih.gov/gene/?term=8870 "DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025176 8871 SYNJ2 http://www.ncbi.nlm.nih.gov/gene/?term=8871 INPP5H mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025177 8872 CDC123 http://www.ncbi.nlm.nih.gov/gene/?term=8872 "C10orf7, D123 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025178 8872 CDC123 http://www.ncbi.nlm.nih.gov/gene/?term=8872 "C10orf7, D123 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025179 8872 CDC123 http://www.ncbi.nlm.nih.gov/gene/?term=8872 "C10orf7, D123 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025180 88745 RRP36 http://www.ncbi.nlm.nih.gov/gene/?term=88745 "C6orf153, dJ20C7.4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025181 88745 RRP36 http://www.ncbi.nlm.nih.gov/gene/?term=88745 "C6orf153, dJ20C7.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025182 8874 ARHGEF7 http://www.ncbi.nlm.nih.gov/gene/?term=8874 "BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025183 8874 ARHGEF7 http://www.ncbi.nlm.nih.gov/gene/?term=8874 "BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025184 8876 VNN1 http://www.ncbi.nlm.nih.gov/gene/?term=8876 "HDLCQ8, Tiff66 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025185 8878 SQSTM1 http://www.ncbi.nlm.nih.gov/gene/?term=8878 "A170, FTDALS3, OSIL, PDB3, ZIP3, p60, p62, p62B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025186 8879 SGPL1 http://www.ncbi.nlm.nih.gov/gene/?term=8879 "S1PL, SPL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025187 8879 SGPL1 http://www.ncbi.nlm.nih.gov/gene/?term=8879 "S1PL, SPL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025188 8879 SGPL1 http://www.ncbi.nlm.nih.gov/gene/?term=8879 "S1PL, SPL " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025189 8879 SGPL1 http://www.ncbi.nlm.nih.gov/gene/?term=8879 "S1PL, SPL " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025190 8879 SGPL1 http://www.ncbi.nlm.nih.gov/gene/?term=8879 "S1PL, SPL " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025191 8880 FUBP1 http://www.ncbi.nlm.nih.gov/gene/?term=8880 "FBP, FUBP, hDH V " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025192 8880 FUBP1 http://www.ncbi.nlm.nih.gov/gene/?term=8880 "FBP, FUBP, hDH V " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025193 8881 CDC16 http://www.ncbi.nlm.nih.gov/gene/?term=8881 "ANAPC6, APC6Hs, CUT9, CDC16 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025194 8881 CDC16 http://www.ncbi.nlm.nih.gov/gene/?term=8881 "ANAPC6, APC6, CDC16Hs, CUT9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025195 8882 ZPR1 http://www.ncbi.nlm.nih.gov/gene/?term=8882 ZNF259 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025196 8883 NAE1 http://www.ncbi.nlm.nih.gov/gene/?term=8883 "A-116A10.1, APPBP1, HPP1, ula-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025197 8883 NAE1 http://www.ncbi.nlm.nih.gov/gene/?term=8883 "A-116A10.1, APPBP1, HPP1, ula-1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025198 8883 NAE1 http://www.ncbi.nlm.nih.gov/gene/?term=8883 "A-116A10.1, APPBP1, HPP1, ula-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025199 8884 SLC5A6 http://www.ncbi.nlm.nih.gov/gene/?term=8884 SMVT mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025200 8884 SLC5A6 http://www.ncbi.nlm.nih.gov/gene/?term=8884 SMVT mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025201 8884 SLC5A6 http://www.ncbi.nlm.nih.gov/gene/?term=8884 SMVT mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025202 8886 DDX18 http://www.ncbi.nlm.nih.gov/gene/?term=8886 MrDb mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025203 8886 DDX18 http://www.ncbi.nlm.nih.gov/gene/?term=8886 MrDb mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025204 8887 TAX1BP1 http://www.ncbi.nlm.nih.gov/gene/?term=8887 "CALCOCO3, T6BP, TXBP151 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025205 8887 TAX1BP1 http://www.ncbi.nlm.nih.gov/gene/?term=8887 "CALCOCO3, T6BP, TXBP151 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025206 8888 MCM3AP http://www.ncbi.nlm.nih.gov/gene/?term=8888 "GANP, MAP80, SAC3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025207 8888 MCM3AP http://www.ncbi.nlm.nih.gov/gene/?term=8888 "GANP, MAP80, SAC3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025208 8888 MCM3AP http://www.ncbi.nlm.nih.gov/gene/?term=8888 "GANP, MAP80, SAC3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025209 8890 EIF2B4 http://www.ncbi.nlm.nih.gov/gene/?term=8890 "EIF-2B, EIF2B, EIF2Bdelta " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025210 8890 EIF2B4 http://www.ncbi.nlm.nih.gov/gene/?term=8890 "EIF-2B, EIF2B, EIF2Bdelta " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025211 8890 EIF2B4 http://www.ncbi.nlm.nih.gov/gene/?term=8890 "EIF-2B, EIF2B, EIF2Bdelta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025212 8892 EIF2B2 http://www.ncbi.nlm.nih.gov/gene/?term=8892 "EIF-2Bbeta, EIF2B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025213 8892 EIF2B2 http://www.ncbi.nlm.nih.gov/gene/?term=8892 "EIF-2Bbeta, EIF2B " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025214 8892 EIF2B2 http://www.ncbi.nlm.nih.gov/gene/?term=8892 "EIF-2Bbeta, EIF2B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025215 8893 EIF2B5 http://www.ncbi.nlm.nih.gov/gene/?term=8893 "CACH, CLE, EIF-2B, EIF2Bepsilon, LVWM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025216 8894 EIF2S2 http://www.ncbi.nlm.nih.gov/gene/?term=8894 "EIF2, EIF2B, EIF2beta, PPP1R67, eIF-2-beta " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025217 8894 EIF2S2 http://www.ncbi.nlm.nih.gov/gene/?term=8894 "EIF2, EIF2B, EIF2beta, PPP1R67, eIF-2-beta " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025218 8895 CPNE3 http://www.ncbi.nlm.nih.gov/gene/?term=8895 "CPN3, PRO1071 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025219 8896 BUD31 http://www.ncbi.nlm.nih.gov/gene/?term=8896 "Cwc14, EDG-2, EDG2, G10, YCR063W, fSAP17 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025220 8896 BUD31 http://www.ncbi.nlm.nih.gov/gene/?term=8896 "Cwc14, EDG-2, EDG2, G10, YCR063W, fSAP17 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025221 8897 MTMR3 http://www.ncbi.nlm.nih.gov/gene/?term=8897 "FYVE-DSP1, ZFYVE10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025222 8898 MTMR2 http://www.ncbi.nlm.nih.gov/gene/?term=8898 "CMT4B, CMT4B1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025223 8898 MTMR2 http://www.ncbi.nlm.nih.gov/gene/?term=8898 "CMT4B, CMT4B1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025224 8898 MTMR2 http://www.ncbi.nlm.nih.gov/gene/?term=8898 "CMT4B, CMT4B1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025225 8899 PRPF4B http://www.ncbi.nlm.nih.gov/gene/?term=8899 "PR4H, PRP4, PRP4H, PRP4K, dJ1013A10.1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025226 8904 CPNE1 http://www.ncbi.nlm.nih.gov/gene/?term=8904 "COPN1, CPN1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025227 8904 CPNE1 http://www.ncbi.nlm.nih.gov/gene/?term=8904 "COPN1, CPN1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025228 8905 AP1S2 http://www.ncbi.nlm.nih.gov/gene/?term=8905 "DC22, MRX59, MRXS21, MRXS5, MRXSF, PGS, SIGMA1B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025229 8906 AP1G2 http://www.ncbi.nlm.nih.gov/gene/?term=8906 G2AD mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025230 8906 AP1G2 http://www.ncbi.nlm.nih.gov/gene/?term=8906 G2AD mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025231 8907 AP1M1 http://www.ncbi.nlm.nih.gov/gene/?term=8907 "AP47, CLAPM2, CLTNM, MU-1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025232 8908 GYG2 http://www.ncbi.nlm.nih.gov/gene/?term=8908 "GN-2, GN2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025233 890 CCNA2 http://www.ncbi.nlm.nih.gov/gene/?term=890 "CCN1, CCNA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025234 890 CCNA2 http://www.ncbi.nlm.nih.gov/gene/?term=890 "CCN1, CCNA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025235 890 CCNA2 http://www.ncbi.nlm.nih.gov/gene/?term=890 "CCN1, CCNA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025236 8910 SGCE http://www.ncbi.nlm.nih.gov/gene/?term=8910 "DYT11, ESG " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025237 8910 SGCE http://www.ncbi.nlm.nih.gov/gene/?term=8910 "DYT11, ESG " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025238 8911 CACNA1I http://www.ncbi.nlm.nih.gov/gene/?term=8911 "Cav3.3, ca(v)3.3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025239 8914 TIMELESS http://www.ncbi.nlm.nih.gov/gene/?term=8914 "TIM, TIM1, hTIM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025240 8915 BCL10 http://www.ncbi.nlm.nih.gov/gene/?term=8915 "CARMEN, CIPER, CLAP, IMD37, c-E10, mE10 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025241 8915 BCL10 http://www.ncbi.nlm.nih.gov/gene/?term=8915 "CARMEN, CIPER, CLAP, IMD37, c-E10, mE10 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025242 8916 HERC3 http://www.ncbi.nlm.nih.gov/gene/?term=8916 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025243 8916 HERC3 http://www.ncbi.nlm.nih.gov/gene/?term=8916 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025244 891 CCNB1 http://www.ncbi.nlm.nih.gov/gene/?term=891 CCNB mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025245 8924 HERC2 http://www.ncbi.nlm.nih.gov/gene/?term=8924 "D15F37S1, MRT38, SHEP1, jdf2, p528 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025246 8924 HERC2 http://www.ncbi.nlm.nih.gov/gene/?term=8924 "D15F37S1, MRT38, SHEP1, jdf2, p528 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025247 8925 HERC1 http://www.ncbi.nlm.nih.gov/gene/?term=8925 "p532, p619 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025248 892 CCNC http://www.ncbi.nlm.nih.gov/gene/?term=892 CycC mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025249 892 CCNC http://www.ncbi.nlm.nih.gov/gene/?term=892 CycC mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025250 8930 MBD4 http://www.ncbi.nlm.nih.gov/gene/?term=8930 MED1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025251 8930 MBD4 http://www.ncbi.nlm.nih.gov/gene/?term=8930 MED1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025252 8932 MBD2 http://www.ncbi.nlm.nih.gov/gene/?term=8932 "DMTase, NY-CO-41 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025253 8932 MBD2 http://www.ncbi.nlm.nih.gov/gene/?term=8932 "DMTase, NY-CO-41 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025254 8932 MBD2 http://www.ncbi.nlm.nih.gov/gene/?term=8932 "DMTase, NY-CO-41 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025255 8933 FAM127A http://www.ncbi.nlm.nih.gov/gene/?term=8933 "CXX1, MAR8C, MART8C, Mar8, Mart8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025256 8933 FAM127A http://www.ncbi.nlm.nih.gov/gene/?term=8933 "CXX1, MAR8C, MART8C, Mar8, Mart8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025257 8939 FUBP3 http://www.ncbi.nlm.nih.gov/gene/?term=8939 FBP3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025258 8939 FUBP3 http://www.ncbi.nlm.nih.gov/gene/?term=8939 FBP3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025259 8941 CDK5R2 http://www.ncbi.nlm.nih.gov/gene/?term=8941 "NCK5AI, P39, p39nck5ai " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025260 8943 AP3D1 http://www.ncbi.nlm.nih.gov/gene/?term=8943 "ADTD, hBLVR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025261 8943 AP3D1 http://www.ncbi.nlm.nih.gov/gene/?term=8943 "ADTD, hBLVR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025262 8944 SNORD73A http://www.ncbi.nlm.nih.gov/gene/?term=8944 "RNU73, RNU73A, U73, U73a " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00025263 894 CCND2 http://www.ncbi.nlm.nih.gov/gene/?term=894 "KIAK0002, MPPH3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025264 894 CCND2 http://www.ncbi.nlm.nih.gov/gene/?term=894 "KIAK0002, MPPH3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025265 8969 HIST1H2AG http://www.ncbi.nlm.nih.gov/gene/?term=8969 "H2A.1b, H2A/p, H2AFP, H2AG, pH2A/f " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025266 8969 HIST1H2AG http://www.ncbi.nlm.nih.gov/gene/?term=8969 "H2A.1b, H2A/p, H2AFP, H2AG, pH2A/f " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025267 8969 HIST1H2AG http://www.ncbi.nlm.nih.gov/gene/?term=8969 "H2A.1b, H2A/p, H2AFP, H2AG, pH2A/f " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025268 8970 HIST1H2BJ http://www.ncbi.nlm.nih.gov/gene/?term=8970 "H2B/r, H2BFR, H2BJ " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025269 8971 H1FX http://www.ncbi.nlm.nih.gov/gene/?term=8971 "H1.10, H1X " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025270 8971 H1FX http://www.ncbi.nlm.nih.gov/gene/?term=8971 "H1.10, H1X " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025271 8972 MGAM http://www.ncbi.nlm.nih.gov/gene/?term=8972 "MG, MGA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025272 8974 P4HA2 http://www.ncbi.nlm.nih.gov/gene/?term=8974 mRNA Homo sapiens 25753659 Endoplasmic reticulum HT1080 cell Fluorescence in situ hybridization Table 1. Motif enrichment in 5'- and 3'-UTRs of candidates that are increased in total mRNA level and being increasingly present at the ER during hypoxia in HT1080 cells. Data are collected from Table 1. RLID00025273 8975 USP13 http://www.ncbi.nlm.nih.gov/gene/?term=8975 "ISOT3, IsoT-3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025274 8976 WASL http://www.ncbi.nlm.nih.gov/gene/?term=8976 "N-WASP, NWASP, WASPB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025275 8976 WASL http://www.ncbi.nlm.nih.gov/gene/?term=8976 "N-WASP, NWASP, WASPB " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025276 8976 WASL http://www.ncbi.nlm.nih.gov/gene/?term=8976 "N-WASP, NWASP, WASPB " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025277 89781 HPS4 http://www.ncbi.nlm.nih.gov/gene/?term=89781 "BLOC3S2, LE " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025278 89781 HPS4 http://www.ncbi.nlm.nih.gov/gene/?term=89781 "BLOC3S2, LE " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025279 89781 HPS4 http://www.ncbi.nlm.nih.gov/gene/?term=89781 "BLOC3S2, LE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025280 89782 LMLN http://www.ncbi.nlm.nih.gov/gene/?term=89782 "GP63, INV, IX14, MSP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025281 89795 NAV3 http://www.ncbi.nlm.nih.gov/gene/?term=89795 "POMFIL1, STEERIN3, unc53H3 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025282 89796 NAV1 http://www.ncbi.nlm.nih.gov/gene/?term=89796 "POMFIL3, STEERIN1, UNC53H1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025283 89796 NAV1 http://www.ncbi.nlm.nih.gov/gene/?term=89796 "POMFIL3, STEERIN1, UNC53H1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025284 89796 NAV1 http://www.ncbi.nlm.nih.gov/gene/?term=89796 "POMFIL3, STEERIN1, UNC53H1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025285 89797 NAV2 http://www.ncbi.nlm.nih.gov/gene/?term=89797 "HELAD1, POMFIL2, RAINB1, STEERIN2, UNC53H2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025286 89797 NAV2 http://www.ncbi.nlm.nih.gov/gene/?term=89797 "HELAD1, POMFIL2, RAINB1, STEERIN2, UNC53H2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025287 89801 PPP1R3F http://www.ncbi.nlm.nih.gov/gene/?term=89801 "HB2E, R3F " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025288 89832 CHRFAM7A http://www.ncbi.nlm.nih.gov/gene/?term=89832 "CHRNA7, CHRNA7-DR1, D-10 " mRNA Homo sapiens 26206074 Nucleus Neocortex In situ hybridization "CHRNA7 and CHRFAM7A mRNAs were expressed in the same neuronal nuclei of the human neocortex. We demonstrated that CHRNA7 and CHRFAM7A mRNAs are colocalized in a subset of putative neuronal nuclei (large DAPI-stained nuclei), both in the dorsolateral prefrontal cortex and anterior cingulate cortex (Figure 3). " RLID00025289 89848 FCHSD1 http://www.ncbi.nlm.nih.gov/gene/?term=89848 NWK2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025290 89849 ATG16L2 http://www.ncbi.nlm.nih.gov/gene/?term=89849 "ATG16B, WDR80 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025291 89853 MVB12B http://www.ncbi.nlm.nih.gov/gene/?term=89853 "C9orf28, FAM125B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025292 89857 KLHL6 http://www.ncbi.nlm.nih.gov/gene/?term=89857 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025293 89857 KLHL6 http://www.ncbi.nlm.nih.gov/gene/?term=89857 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025294 8985 PLOD3 http://www.ncbi.nlm.nih.gov/gene/?term=8985 LH3 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025295 8985 PLOD3 http://www.ncbi.nlm.nih.gov/gene/?term=8985 LH3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025296 89870 TRIM15 http://www.ncbi.nlm.nih.gov/gene/?term=89870 "RNF93, ZNF178, ZNFB7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025297 89872 AQP10 http://www.ncbi.nlm.nih.gov/gene/?term=89872 AQPA_HUMAN mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00025298 89874 SLC25A21 http://www.ncbi.nlm.nih.gov/gene/?term=89874 "ODC, ODC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025299 89885 FATE1 http://www.ncbi.nlm.nih.gov/gene/?term=89885 "CT43, FATE " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025300 89891 WDR34 http://www.ncbi.nlm.nih.gov/gene/?term=89891 "DIC5, FAP133, SRTD11, bA216B9.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025301 89891 WDR34 http://www.ncbi.nlm.nih.gov/gene/?term=89891 "DIC5, FAP133, SRTD11, bA216B9.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025302 89894 TMEM116 http://www.ncbi.nlm.nih.gov/gene/?term=89894 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025303 89894 TMEM116 http://www.ncbi.nlm.nih.gov/gene/?term=89894 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025304 89894 TMEM116 http://www.ncbi.nlm.nih.gov/gene/?term=89894 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025305 898 CCNE1 http://www.ncbi.nlm.nih.gov/gene/?term=898 "CCNE, pCCNE1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025306 898 CCNE1 http://www.ncbi.nlm.nih.gov/gene/?term=898 "CCNE, pCCNE1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025307 89910 UBE3B http://www.ncbi.nlm.nih.gov/gene/?term=89910 "BPIDS, KOS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025308 8991 SELENBP1 http://www.ncbi.nlm.nih.gov/gene/?term=8991 "HEL-S-134P, LPSB, SBP56, SP56, hSBP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025309 8991 SELENBP1 http://www.ncbi.nlm.nih.gov/gene/?term=8991 "HEL-S-134P, LPSB, SBP56, SP56, hSBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025310 89927 C16orf45 http://www.ncbi.nlm.nih.gov/gene/?term=89927 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025311 8992 ATP6V0E1 http://www.ncbi.nlm.nih.gov/gene/?term=8992 "ATP6H, ATP6V0E, M9.2, Vma21, Vma21p " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025312 8992 ATP6V0E1 http://www.ncbi.nlm.nih.gov/gene/?term=8992 "ATP6H, ATP6V0E, M9.2, Vma21, Vma21p " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025313 89941 RHOT2 http://www.ncbi.nlm.nih.gov/gene/?term=89941 "ARHT2, C16orf39, MIRO-2, MIRO2, RASL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025314 89941 RHOT2 http://www.ncbi.nlm.nih.gov/gene/?term=89941 "ARHT2, C16orf39, MIRO-2, MIRO2, RASL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025315 89944 GLB1L2 http://www.ncbi.nlm.nih.gov/gene/?term=89944 "MST114, MSTP114 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025316 89944 GLB1L2 http://www.ncbi.nlm.nih.gov/gene/?term=89944 "MST114, MSTP114 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025317 8994 LIMD1 http://www.ncbi.nlm.nih.gov/gene/?term=8994 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025318 8994 LIMD1 http://www.ncbi.nlm.nih.gov/gene/?term=8994 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025319 8994 LIMD1 http://www.ncbi.nlm.nih.gov/gene/?term=8994 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025320 89953 KLC4 http://www.ncbi.nlm.nih.gov/gene/?term=89953 "KNSL8, bA387M24.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025321 89958 SAPCD2 http://www.ncbi.nlm.nih.gov/gene/?term=89958 "C9orf140, p42.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025322 89958 SAPCD2 http://www.ncbi.nlm.nih.gov/gene/?term=89958 "C9orf140, p42.3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025323 8996 NOL3 http://www.ncbi.nlm.nih.gov/gene/?term=8996 "ARC, FCM, MYP, NOP, NOP30 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025324 89970 RSPRY1 http://www.ncbi.nlm.nih.gov/gene/?term=89970 SEMDFA mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025325 89970 RSPRY1 http://www.ncbi.nlm.nih.gov/gene/?term=89970 SEMDFA mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025326 89970 RSPRY1 http://www.ncbi.nlm.nih.gov/gene/?term=89970 SEMDFA mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025327 89978 DPH6 http://www.ncbi.nlm.nih.gov/gene/?term=89978 ATPBD4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025328 899 CCNF http://www.ncbi.nlm.nih.gov/gene/?term=899 "FBX1, FBXO1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025329 89 ACTN3 http://www.ncbi.nlm.nih.gov/gene/?term=89 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025330 90011 KIR3DX1 http://www.ncbi.nlm.nih.gov/gene/?term=90011 "KIR3DL0, LENG12 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025331 90011 KIR3DX1 http://www.ncbi.nlm.nih.gov/gene/?term=90011 "KIR3DL0, LENG12 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025332 90024 FLJ20021 http://www.ncbi.nlm.nih.gov/gene/?term=90024 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025333 90025 UBE3D http://www.ncbi.nlm.nih.gov/gene/?term=90025 "C6orf157, H10BH, UBE2CBP, YJR141W " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025334 90025 UBE3D http://www.ncbi.nlm.nih.gov/gene/?term=90025 "C6orf157, H10BH, UBE2CBP, YJR141W " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025335 90075 ZNF30 http://www.ncbi.nlm.nih.gov/gene/?term=90075 KOX28 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025336 900 CCNG1 http://www.ncbi.nlm.nih.gov/gene/?term=900 CCNG mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025337 90120 C9orf69 http://www.ncbi.nlm.nih.gov/gene/?term=90120 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025338 90121 TSR2 http://www.ncbi.nlm.nih.gov/gene/?term=90121 "DBA14, DT1P1A10, WGG1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025339 90121 TSR2 http://www.ncbi.nlm.nih.gov/gene/?term=90121 "DBA14, DT1P1A10, WGG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025340 90133 KRT8P12 http://www.ncbi.nlm.nih.gov/gene/?term=90133 KRT8L2 lncRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025341 90134 KCNH7 http://www.ncbi.nlm.nih.gov/gene/?term=90134 "ERG3, HERG3, Kv11.3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025342 90135 BTBD6 http://www.ncbi.nlm.nih.gov/gene/?term=90135 BDPL mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025343 90135 BTBD6 http://www.ncbi.nlm.nih.gov/gene/?term=90135 BDPL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025344 90139 TSPAN18 http://www.ncbi.nlm.nih.gov/gene/?term=90139 TSPAN mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025345 9013 TAF1C http://www.ncbi.nlm.nih.gov/gene/?term=9013 "MGC:39976, SL1, TAFI110, TAFI95 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025346 90141 EFCAB11 http://www.ncbi.nlm.nih.gov/gene/?term=90141 C14orf143 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025347 90141 EFCAB11 http://www.ncbi.nlm.nih.gov/gene/?term=90141 C14orf143 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025348 9014 TAF1B http://www.ncbi.nlm.nih.gov/gene/?term=9014 "MGC:9349, RAF1B, RAFI63, SL1, TAFI63 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025349 9016 SLC25A14 http://www.ncbi.nlm.nih.gov/gene/?term=9016 "BMCP1, UCP5 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025350 90196 SYS1 http://www.ncbi.nlm.nih.gov/gene/?term=90196 "C20orf169, dJ453C12.4, dJ453C12.4.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025351 90199 WFDC8 http://www.ncbi.nlm.nih.gov/gene/?term=90199 "C20orf170, HEL-S-292, WAP8, dJ461P17.1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025352 90199 WFDC8 http://www.ncbi.nlm.nih.gov/gene/?term=90199 "C20orf170, HEL-S-292, WAP8, dJ461P17.1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025353 9019 MPZL1 http://www.ncbi.nlm.nih.gov/gene/?term=9019 "MPZL1b, PZR, PZR1b, PZRa, PZRb " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025354 9019 MPZL1 http://www.ncbi.nlm.nih.gov/gene/?term=9019 "MPZL1b, PZR, PZR1b, PZRa, PZRb " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025355 901 CCNG2 http://www.ncbi.nlm.nih.gov/gene/?term=901 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025356 901 CCNG2 http://www.ncbi.nlm.nih.gov/gene/?term=901 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025357 90203 SNX21 http://www.ncbi.nlm.nih.gov/gene/?term=90203 "C20orf161, PP3993, SNX-L, dJ337O18.4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025358 9021 SOCS3 http://www.ncbi.nlm.nih.gov/gene/?term=9021 "ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025359 9022 CLIC3 http://www.ncbi.nlm.nih.gov/gene/?term=9022 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025360 90231 KIAA2013 http://www.ncbi.nlm.nih.gov/gene/?term=90231 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025361 90233 ZNF551 http://www.ncbi.nlm.nih.gov/gene/?term=90233 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025362 9025 RNF8 http://www.ncbi.nlm.nih.gov/gene/?term=9025 hRNF8 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025363 9025 RNF8 http://www.ncbi.nlm.nih.gov/gene/?term=9025 hRNF8 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025364 9025 RNF8 http://www.ncbi.nlm.nih.gov/gene/?term=9025 hRNF8 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025365 9025 RNF8 http://www.ncbi.nlm.nih.gov/gene/?term=9025 hRNF8 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025366 90268 OTULIN http://www.ncbi.nlm.nih.gov/gene/?term=90268 "FAM105B, GUM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025367 90268 OTULIN http://www.ncbi.nlm.nih.gov/gene/?term=90268 "FAM105B, GUM " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025368 90268 OTULIN http://www.ncbi.nlm.nih.gov/gene/?term=90268 "FAM105B, GUM " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025369 90268 OTULIN http://www.ncbi.nlm.nih.gov/gene/?term=90268 "FAM105B, GUM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025370 9026 HIP1R http://www.ncbi.nlm.nih.gov/gene/?term=9026 "HIP12, HIP3, ILWEQ " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025371 90293 KLHL13 http://www.ncbi.nlm.nih.gov/gene/?term=90293 BKLHD2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025372 902 CCNH http://www.ncbi.nlm.nih.gov/gene/?term=902 "CAK, CycH, p34, p37 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025373 902 CCNH http://www.ncbi.nlm.nih.gov/gene/?term=902 "CAK, CycH, p34, p37 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025374 9031 BAZ1B http://www.ncbi.nlm.nih.gov/gene/?term=9031 "WBSCR10, WBSCR9, WSTF " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025375 9031 BAZ1B http://www.ncbi.nlm.nih.gov/gene/?term=9031 "WBSCR10, WBSCR9, WSTF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025376 90326 THAP3 http://www.ncbi.nlm.nih.gov/gene/?term=90326 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025377 90362 FAM110B http://www.ncbi.nlm.nih.gov/gene/?term=90362 C8orf72 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025378 90378 SAMD1 http://www.ncbi.nlm.nih.gov/gene/?term=90378 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025379 90379 DCAF15 http://www.ncbi.nlm.nih.gov/gene/?term=90379 C19orf72 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025380 9037 SEMA5A http://www.ncbi.nlm.nih.gov/gene/?term=9037 "SEMAF, semF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025381 90390 MED30 http://www.ncbi.nlm.nih.gov/gene/?term=90390 "MED30S, THRAP6, TRAP25 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025382 9039 UBA3 http://www.ncbi.nlm.nih.gov/gene/?term=9039 "NAE2, UBE1C, hUBA3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025383 90407 TMEM41A http://www.ncbi.nlm.nih.gov/gene/?term=90407 2900010K02Rik mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025384 9040 UBE2M http://www.ncbi.nlm.nih.gov/gene/?term=9040 "UBC-RS2, UBC12, hUbc12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025385 9040 UBE2M http://www.ncbi.nlm.nih.gov/gene/?term=9040 "UBC-RS2, UBC12, hUbc12 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025386 90410 IFT20 http://www.ncbi.nlm.nih.gov/gene/?term=90410 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025387 90410 IFT20 http://www.ncbi.nlm.nih.gov/gene/?term=90410 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025388 90410 IFT20 http://www.ncbi.nlm.nih.gov/gene/?term=90410 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025389 90411 MCFD2 http://www.ncbi.nlm.nih.gov/gene/?term=90411 "F5F8D, F5F8D2, LMAN1IP, SDNSF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025390 90411 MCFD2 http://www.ncbi.nlm.nih.gov/gene/?term=90411 "F5F8D, F5F8D2, LMAN1IP, SDNSF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025391 90416 C15orf57 http://www.ncbi.nlm.nih.gov/gene/?term=90416 CCDC32 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025392 90416 C15orf57 http://www.ncbi.nlm.nih.gov/gene/?term=90416 CCDC32 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025393 90417 KNSTRN http://www.ncbi.nlm.nih.gov/gene/?term=90417 "C15orf23, HSD11, SKAP, TRAF4AF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025394 90417 KNSTRN http://www.ncbi.nlm.nih.gov/gene/?term=90417 "C15orf23, HSD11, SKAP, TRAF4AF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025395 9044 BTAF1 http://www.ncbi.nlm.nih.gov/gene/?term=9044 "MOT1, TAF(II)170, TAF172, TAFII170 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025396 9044 BTAF1 http://www.ncbi.nlm.nih.gov/gene/?term=9044 "MOT1, TAF(II)170, TAF172, TAFII170 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025397 90459 ERI1 http://www.ncbi.nlm.nih.gov/gene/?term=90459 "3'HEXO, HEXO, THEX1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025398 90459 ERI1 http://www.ncbi.nlm.nih.gov/gene/?term=90459 "3'HEXO, HEXO, THEX1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025399 9045 RPL14 http://www.ncbi.nlm.nih.gov/gene/?term=9045 "CAG-ISL-7, CTG-B33, L14, RL14, hRL14 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025400 9045 RPL14 http://www.ncbi.nlm.nih.gov/gene/?term=9045 "CAG-ISL-7, CTG-B33, L14, RL14, hRL14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025401 9047 SH2D2A http://www.ncbi.nlm.nih.gov/gene/?term=9047 "F2771, SCAP, TSAD, VRAP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025402 90480 GADD45GIP1 http://www.ncbi.nlm.nih.gov/gene/?term=90480 "CKBBP2, CKbetaBP2, CRIF1, MRP-L59, PLINP, PLINP-1, PRG6, Plinp1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025403 90480 GADD45GIP1 http://www.ncbi.nlm.nih.gov/gene/?term=90480 "CKBBP2, CKbetaBP2, CRIF1, MRP-L59, PLINP, PLINP-1, PRG6, Plinp1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025404 90488 TMEM263 http://www.ncbi.nlm.nih.gov/gene/?term=90488 C12orf23 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025405 90488 TMEM263 http://www.ncbi.nlm.nih.gov/gene/?term=90488 C12orf23 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025406 9049 AIP http://www.ncbi.nlm.nih.gov/gene/?term=9049 "ARA9, FKBP16, FKBP37, SMTPHN, XAP-2, XAP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025407 9049 AIP http://www.ncbi.nlm.nih.gov/gene/?term=9049 "ARA9, FKBP16, FKBP37, SMTPHN, XAP-2, XAP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025408 904 CCNT1 http://www.ncbi.nlm.nih.gov/gene/?term=904 "CCNT, CYCT1, HIVE1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025409 904 CCNT1 http://www.ncbi.nlm.nih.gov/gene/?term=904 "CCNT, CYCT1, HIVE1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025410 9050 PSTPIP2 http://www.ncbi.nlm.nih.gov/gene/?term=9050 MAYP mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025411 9050 PSTPIP2 http://www.ncbi.nlm.nih.gov/gene/?term=9050 MAYP mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025412 90522 YIF1B http://www.ncbi.nlm.nih.gov/gene/?term=90522 FinGER8 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025413 90523 MLIP http://www.ncbi.nlm.nih.gov/gene/?term=90523 C6orf142 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025414 90527 DUOXA1 http://www.ncbi.nlm.nih.gov/gene/?term=90527 "NIP, NUMBIP, mol " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025415 90527 DUOXA1 http://www.ncbi.nlm.nih.gov/gene/?term=90527 "NIP, NUMBIP, mol " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025416 9052 GPRC5A http://www.ncbi.nlm.nih.gov/gene/?term=9052 "GPCR5A, PEIG-1, RAI3, RAIG1, TIG1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025417 9052 GPRC5A http://www.ncbi.nlm.nih.gov/gene/?term=9052 "GPCR5A, PEIG-1, RAI3, RAIG1, TIG1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025418 9052 GPRC5A http://www.ncbi.nlm.nih.gov/gene/?term=9052 "GPCR5A, PEIG-1, RAI3, RAIG1, TIG1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025419 9053 MAP7 http://www.ncbi.nlm.nih.gov/gene/?term=9053 "E-MAP-115, EMAP115 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025420 9053 MAP7 http://www.ncbi.nlm.nih.gov/gene/?term=9053 "E-MAP-115, EMAP115 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025421 9054 NFS1 http://www.ncbi.nlm.nih.gov/gene/?term=9054 "HUSSY-08, IscS, NIFS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025422 9054 NFS1 http://www.ncbi.nlm.nih.gov/gene/?term=9054 "HUSSY-08, IscS, NIFS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025423 90550 MCU http://www.ncbi.nlm.nih.gov/gene/?term=90550 "C10orf42, CCDC109A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025424 9055 PRC1 http://www.ncbi.nlm.nih.gov/gene/?term=9055 ASE1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025425 9055 PRC1 http://www.ncbi.nlm.nih.gov/gene/?term=9055 ASE1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025426 9055 PRC1 http://www.ncbi.nlm.nih.gov/gene/?term=9055 ASE1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025427 9056 SLC7A7 http://www.ncbi.nlm.nih.gov/gene/?term=9056 "LAT3, LPI, MOP-2, Y+LAT1, y+LAT-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025428 9057 SLC7A6 http://www.ncbi.nlm.nih.gov/gene/?term=9057 "LAT-2, LAT3, y+LAT-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025429 90580 C19orf52 http://www.ncbi.nlm.nih.gov/gene/?term=90580 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025430 905 CCNT2 http://www.ncbi.nlm.nih.gov/gene/?term=905 CYCT2 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025431 905 CCNT2 http://www.ncbi.nlm.nih.gov/gene/?term=905 CYCT2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025432 905 CCNT2 http://www.ncbi.nlm.nih.gov/gene/?term=905 CYCT2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025433 9060 PAPSS2 http://www.ncbi.nlm.nih.gov/gene/?term=9060 "ATPSK2, BCYM4, SK2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025434 9061 PAPSS1 http://www.ncbi.nlm.nih.gov/gene/?term=9061 "ATPSK1, PAPSS, SK1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025435 9061 PAPSS1 http://www.ncbi.nlm.nih.gov/gene/?term=9061 "ATPSK1, PAPSS, SK1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025436 90624 LYRM7 http://www.ncbi.nlm.nih.gov/gene/?term=90624 "C5orf31, MC3DN8, MZM1L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025437 90624 LYRM7 http://www.ncbi.nlm.nih.gov/gene/?term=90624 "C5orf31, MC3DN8, MZM1L " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025438 90624 LYRM7 http://www.ncbi.nlm.nih.gov/gene/?term=90624 "C5orf31, MC3DN8, MZM1L " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025439 90624 LYRM7 http://www.ncbi.nlm.nih.gov/gene/?term=90624 "C5orf31, MC3DN8, MZM1L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025440 90627 STARD13 http://www.ncbi.nlm.nih.gov/gene/?term=90627 "ARHGAP37, DLC2, GT650, LINC00464 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025441 90639 COX19 http://www.ncbi.nlm.nih.gov/gene/?term=90639 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025442 90639 COX19 http://www.ncbi.nlm.nih.gov/gene/?term=90639 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025443 9063 PIAS2 http://www.ncbi.nlm.nih.gov/gene/?term=9063 "ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025444 9064 MAP3K6 http://www.ncbi.nlm.nih.gov/gene/?term=9064 "ASK2, MAPKKK6, MEKK6 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025445 90668 CARMIL3 http://www.ncbi.nlm.nih.gov/gene/?term=90668 "C14orf121, CARMIL3, crml-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025446 9068 ANGPTL1 http://www.ncbi.nlm.nih.gov/gene/?term=9068 "ANG3, ANGPT3, ARP1, AngY, UNQ162, dJ595C2.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025447 90693 CCDC126 http://www.ncbi.nlm.nih.gov/gene/?term=90693 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025448 9069 CLDN12 http://www.ncbi.nlm.nih.gov/gene/?term=9069 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025449 90701 SEC11C http://www.ncbi.nlm.nih.gov/gene/?term=90701 "SEC11L3, SPC21, SPCS4C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025450 9071 CLDN10 http://www.ncbi.nlm.nih.gov/gene/?term=9071 "CPETRL3, OSP-L " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025451 9075 CLDN2 http://www.ncbi.nlm.nih.gov/gene/?term=9075 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025452 9076 CLDN1 http://www.ncbi.nlm.nih.gov/gene/?term=9076 "CLD1, ILVASC, SEMP1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025453 9077 DIRAS3 http://www.ncbi.nlm.nih.gov/gene/?term=9077 "ARHI, NOEY2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025454 90780 PYGO2 http://www.ncbi.nlm.nih.gov/gene/?term=90780 1190004M21Rik mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025455 90780 PYGO2 http://www.ncbi.nlm.nih.gov/gene/?term=90780 1190004M21Rik mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025456 90799 CEP95 http://www.ncbi.nlm.nih.gov/gene/?term=90799 CCDC45 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025457 90799 CEP95 http://www.ncbi.nlm.nih.gov/gene/?term=90799 CCDC45 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025458 90806 ANGEL2 http://www.ncbi.nlm.nih.gov/gene/?term=90806 "Ccr4d, KIAA0759L " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025459 90806 ANGEL2 http://www.ncbi.nlm.nih.gov/gene/?term=90806 "Ccr4d, KIAA0759L " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025460 90806 ANGEL2 http://www.ncbi.nlm.nih.gov/gene/?term=90806 "Ccr4d, KIAA0759L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025461 90809 TMEM55B http://www.ncbi.nlm.nih.gov/gene/?term=90809 C14orf9 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025462 90809 TMEM55B http://www.ncbi.nlm.nih.gov/gene/?term=90809 C14orf9 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025463 90826 PRMT9 http://www.ncbi.nlm.nih.gov/gene/?term=90826 PRMT10 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025464 90843 TCEAL8 http://www.ncbi.nlm.nih.gov/gene/?term=90843 WEX3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025465 90850 ZNF598 http://www.ncbi.nlm.nih.gov/gene/?term=90850 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025466 90850 ZNF598 http://www.ncbi.nlm.nih.gov/gene/?term=90850 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025467 90861 HN1L http://www.ncbi.nlm.nih.gov/gene/?term=90861 "C16orf34, L11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025468 90861 HN1L http://www.ncbi.nlm.nih.gov/gene/?term=90861 "C16orf34, L11 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025469 90861 HN1L http://www.ncbi.nlm.nih.gov/gene/?term=90861 "C16orf34, L11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025470 9086 EIF1AY http://www.ncbi.nlm.nih.gov/gene/?term=9086 eIF-4C mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025471 90871 TMEM261 http://www.ncbi.nlm.nih.gov/gene/?term=90871 C9orf123 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025472 90871 TMEM261 http://www.ncbi.nlm.nih.gov/gene/?term=90871 C9orf123 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025473 90874 ZNF697 http://www.ncbi.nlm.nih.gov/gene/?term=90874 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025474 9087 TMSB4Y http://www.ncbi.nlm.nih.gov/gene/?term=9087 TB4Y mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025475 9088 PKMYT1 http://www.ncbi.nlm.nih.gov/gene/?term=9088 "MYT1, PPP1R126 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025476 9088 PKMYT1 http://www.ncbi.nlm.nih.gov/gene/?term=9088 "MYT1, PPP1R126 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025477 908 CCT6A http://www.ncbi.nlm.nih.gov/gene/?term=908 "CCT-zeta, CCT-zeta-1, CCT6, Cctz, HTR3, MoDP-2, TCP-1-zeta, TCP20, TCPZ, TTCP20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025478 908 CCT6A http://www.ncbi.nlm.nih.gov/gene/?term=908 "CCT-zeta, CCT-zeta-1, CCT6, Cctz, HTR3, MoDP-2, TCP-1-zeta, TCP20, TCPZ, TTCP20 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025479 908 CCT6A http://www.ncbi.nlm.nih.gov/gene/?term=908 "CCT-zeta, CCT-zeta-1, CCT6, Cctz, HTR3, MoDP-2, TCP-1-zeta, TCP20, TCPZ, TTCP20 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025480 9091 PIGQ http://www.ncbi.nlm.nih.gov/gene/?term=9091 "GPI1, c407A10.1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025481 9091 PIGQ http://www.ncbi.nlm.nih.gov/gene/?term=9091 "GPI1, c407A10.1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025482 9092 SART1 http://www.ncbi.nlm.nih.gov/gene/?term=9092 "Ara1, HOMS1, SART1259, SNRNP110, Snu66 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025483 9093 DNAJA3 http://www.ncbi.nlm.nih.gov/gene/?term=9093 "HCA57, TID1, hTID-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025484 9094 UNC119 http://www.ncbi.nlm.nih.gov/gene/?term=9094 "HRG4, IMD13, POC7, POC7A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025485 9094 UNC119 http://www.ncbi.nlm.nih.gov/gene/?term=9094 "HRG4, IMD13, POC7, POC7A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025486 90956 ADCK2 http://www.ncbi.nlm.nih.gov/gene/?term=90956 AARF mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025487 90956 ADCK2 http://www.ncbi.nlm.nih.gov/gene/?term=90956 AARF mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025488 9097 USP14 http://www.ncbi.nlm.nih.gov/gene/?term=9097 TGT mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025489 9097 USP14 http://www.ncbi.nlm.nih.gov/gene/?term=9097 TGT mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025490 9097 USP14 http://www.ncbi.nlm.nih.gov/gene/?term=9097 TGT mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025491 90993 CREB3L1 http://www.ncbi.nlm.nih.gov/gene/?term=90993 OASIS mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025492 90 ACVR1 http://www.ncbi.nlm.nih.gov/gene/?term=90 "ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025493 9100 USP10 http://www.ncbi.nlm.nih.gov/gene/?term=9100 UBPO mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025494 9100 USP10 http://www.ncbi.nlm.nih.gov/gene/?term=9100 UBPO mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025495 91010 FMNL3 http://www.ncbi.nlm.nih.gov/gene/?term=91010 "FHOD3, FRL2, WBP-3, WBP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025496 91012 CERS5 http://www.ncbi.nlm.nih.gov/gene/?term=91012 "LASS5, Trh4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025497 91012 CERS5 http://www.ncbi.nlm.nih.gov/gene/?term=91012 "LASS5, Trh4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025498 9101 USP8 http://www.ncbi.nlm.nih.gov/gene/?term=9101 "HumORF8, SPG59, UBPY " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025499 9101 USP8 http://www.ncbi.nlm.nih.gov/gene/?term=9101 "HumORF8, SPG59, UBPY " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025500 91039 DPP9 http://www.ncbi.nlm.nih.gov/gene/?term=91039 "DP9, DPLP9, DPRP-2, DPRP2 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025501 91039 DPP9 http://www.ncbi.nlm.nih.gov/gene/?term=91039 "DP9, DPLP9, DPRP-2, DPRP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025502 9104 RGN http://www.ncbi.nlm.nih.gov/gene/?term=9104 "GNL, HEL-S-41, RC, SMP30 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025503 91050 CCDC149 http://www.ncbi.nlm.nih.gov/gene/?term=91050 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025504 91050 CCDC149 http://www.ncbi.nlm.nih.gov/gene/?term=91050 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025505 91056 AP5B1 http://www.ncbi.nlm.nih.gov/gene/?term=91056 "AP-5, PP1030 " mRNA Homo sapiens 24019514 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmid containing either full-length ALPP, t-ftz, AP1, AP2, AP3, AP4, or AP5 and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (C or Ctrl) or HHT (H) for 30 min and then extracted with digitonin. Cells were then fixed, stained for mRNAs using specific FISH probes (ftz probe was used to detect AP1-5), and imaged. Figure 3A, quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 3. " RLID00025506 91056 AP5B1 http://www.ncbi.nlm.nih.gov/gene/?term=91056 "AP-5, PP1030 " mRNA Homo sapiens 24019514 Nucleus COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmid containing either full-length ALPP, t-ftz, AP1, AP2, AP3, AP4, or AP5 and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (C or Ctrl) or HHT (H) for 30 min and then extracted with digitonin. Cells were then fixed, stained for mRNAs using specific FISH probes (ftz probe was used to detect AP1-5), and imaged. Figure 3A, quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 3. " RLID00025507 91056 AP5B1 http://www.ncbi.nlm.nih.gov/gene/?term=91056 "AP-5, PP1030 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025508 91056 AP5B1 http://www.ncbi.nlm.nih.gov/gene/?term=91056 "AP-5, PP1030 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025509 9107 MTMR6 http://www.ncbi.nlm.nih.gov/gene/?term=9107 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025510 91107 TRIM47 http://www.ncbi.nlm.nih.gov/gene/?term=91107 "GOA, RNF100 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025511 9110 MTMR4 http://www.ncbi.nlm.nih.gov/gene/?term=9110 "FYVE-DSP2, ZFYVE11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025512 9110 MTMR4 http://www.ncbi.nlm.nih.gov/gene/?term=9110 "FYVE-DSP2, ZFYVE11 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025513 9110 MTMR4 http://www.ncbi.nlm.nih.gov/gene/?term=9110 "FYVE-DSP2, ZFYVE11 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025514 9111 NMI http://www.ncbi.nlm.nih.gov/gene/?term=9111 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025515 9112 MTA1 http://www.ncbi.nlm.nih.gov/gene/?term=9112 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025516 9112 MTA1 http://www.ncbi.nlm.nih.gov/gene/?term=9112 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025517 9112 MTA1 http://www.ncbi.nlm.nih.gov/gene/?term=9112 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025518 91133 L3MBTL4 http://www.ncbi.nlm.nih.gov/gene/?term=91133 HsT1031 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025519 91137 SLC25A46 http://www.ncbi.nlm.nih.gov/gene/?term=91137 HMSN6B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025520 9114 ATP6V0D1 http://www.ncbi.nlm.nih.gov/gene/?term=9114 "ATP6D, ATP6DV, P39, VATX, VMA6, VPATPD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025521 9114 ATP6V0D1 http://www.ncbi.nlm.nih.gov/gene/?term=9114 "ATP6D, ATP6DV, P39, VATX, VMA6, VPATPD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025522 9117 SEC22C http://www.ncbi.nlm.nih.gov/gene/?term=9117 SEC22L3 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025523 9117 SEC22C http://www.ncbi.nlm.nih.gov/gene/?term=9117 SEC22L3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025524 9121 SLC16A5 http://www.ncbi.nlm.nih.gov/gene/?term=9121 "MCT5, MCT6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025525 91227 GGTLC2 http://www.ncbi.nlm.nih.gov/gene/?term=91227 GGTL4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025526 9122 SLC16A4 http://www.ncbi.nlm.nih.gov/gene/?term=9122 "MCT4, MCT5 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025527 9122 SLC16A4 http://www.ncbi.nlm.nih.gov/gene/?term=9122 "MCT4, MCT5 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025528 9123 SLC16A3 http://www.ncbi.nlm.nih.gov/gene/?term=9123 "MCT 3, MCT 4, MCT-3, MCT-4, MCT3, MCT4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025529 9123 SLC16A3 http://www.ncbi.nlm.nih.gov/gene/?term=9123 "MCT 3, MCT 4, MCT-3, MCT-4, MCT3, MCT4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025530 91252 SLC39A13 http://www.ncbi.nlm.nih.gov/gene/?term=91252 LZT-Hs9 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025531 9125 RQCD1 http://www.ncbi.nlm.nih.gov/gene/?term=9125 "CAF40, CNOT9, CT129, RCD-1, RCD1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025532 9125 CNOT9 http://www.ncbi.nlm.nih.gov/gene/?term=9125 "CAF40, CNOT9, CT129, RCD-1, RCD1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025533 9126 SMC3 http://www.ncbi.nlm.nih.gov/gene/?term=9126 "BAM, BMH, CDLS3, CSPG6, HCAPL1, SMC3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025534 9126 SMC3 http://www.ncbi.nlm.nih.gov/gene/?term=9126 "BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025535 91272 BOD1 http://www.ncbi.nlm.nih.gov/gene/?term=91272 FAM44B mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025536 91283 MSANTD3 http://www.ncbi.nlm.nih.gov/gene/?term=91283 "C9orf30, L8 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025537 91289 LMF2 http://www.ncbi.nlm.nih.gov/gene/?term=91289 "TMEM112B, TMEM153 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025538 9128 PRPF4 http://www.ncbi.nlm.nih.gov/gene/?term=9128 "HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025539 9128 PRPF4 http://www.ncbi.nlm.nih.gov/gene/?term=9128 "HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025540 91298 C12orf29 http://www.ncbi.nlm.nih.gov/gene/?term=91298 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025541 912 CD1D http://www.ncbi.nlm.nih.gov/gene/?term=912 "CD1A, R3, R3G1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025542 91304 TMEM259 http://www.ncbi.nlm.nih.gov/gene/?term=91304 "ASBABP1, C19orf6, MBRL, MEMBRALIN, R32184_3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025543 91304 TMEM259 http://www.ncbi.nlm.nih.gov/gene/?term=91304 "ASBABP1, C19orf6, MBRL, MEMBRALIN, R32184_3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025544 9130 FAM50A http://www.ncbi.nlm.nih.gov/gene/?term=9130 "9F, DXS9928E, HXC-26, HXC26, XAP5 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025545 9131 AIFM1 http://www.ncbi.nlm.nih.gov/gene/?term=9131 "AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025546 9131 AIFM1 http://www.ncbi.nlm.nih.gov/gene/?term=9131 "AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025547 9133 CCNB2 http://www.ncbi.nlm.nih.gov/gene/?term=9133 HsT17299 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025548 9134 CCNE2 http://www.ncbi.nlm.nih.gov/gene/?term=9134 CYCE2 mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00025549 9134 CCNE2 http://www.ncbi.nlm.nih.gov/gene/?term=9134 CYCE2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025550 9134 CCNE2 http://www.ncbi.nlm.nih.gov/gene/?term=9134 CYCE2 mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00025551 91351 DDX60L http://www.ncbi.nlm.nih.gov/gene/?term=91351 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025552 91351 DDX60L http://www.ncbi.nlm.nih.gov/gene/?term=91351 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025553 9135 RABEP1 http://www.ncbi.nlm.nih.gov/gene/?term=9135 "RAB5EP, RABPT5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025554 9135 RABEP1 http://www.ncbi.nlm.nih.gov/gene/?term=9135 "RAB5EP, RABPT5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025555 91368 CDKN2AIPNL http://www.ncbi.nlm.nih.gov/gene/?term=91368 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025556 91368 CDKN2AIPNL http://www.ncbi.nlm.nih.gov/gene/?term=91368 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025557 91369 ANKRD40 http://www.ncbi.nlm.nih.gov/gene/?term=91369 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025558 91369 ANKRD40 http://www.ncbi.nlm.nih.gov/gene/?term=91369 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025559 9136 RRP9 http://www.ncbi.nlm.nih.gov/gene/?term=9136 "RNU3IP2, U3-55K " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025560 9136 RRP9 http://www.ncbi.nlm.nih.gov/gene/?term=9136 "RNU3IP2, U3-55K " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025561 91373 UAP1L1 http://www.ncbi.nlm.nih.gov/gene/?term=91373 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025562 91373 UAP1L1 http://www.ncbi.nlm.nih.gov/gene/?term=91373 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025563 91373 UAP1L1 http://www.ncbi.nlm.nih.gov/gene/?term=91373 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025564 9138 ARHGEF1 http://www.ncbi.nlm.nih.gov/gene/?term=9138 "GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025565 9139 CBFA2T2 http://www.ncbi.nlm.nih.gov/gene/?term=9139 "EHT, MTGR1, ZMYND3, p85 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025566 9139 CBFA2T2 http://www.ncbi.nlm.nih.gov/gene/?term=9139 "EHT, MTGR1, ZMYND3, p85 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025567 9139 CBFA2T2 http://www.ncbi.nlm.nih.gov/gene/?term=9139 "EHT, MTGR1, ZMYND3, p85 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025568 91408 BTF3L4 http://www.ncbi.nlm.nih.gov/gene/?term=91408 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025569 9140 ATG12 http://www.ncbi.nlm.nih.gov/gene/?term=9140 "APG12, APG12L, FBR93, HAPG12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025570 91419 ATP23 http://www.ncbi.nlm.nih.gov/gene/?term=91419 "KUB3, XRCC6BP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025571 9141 PDCD5 http://www.ncbi.nlm.nih.gov/gene/?term=9141 TFAR19 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025572 9141 PDCD5 http://www.ncbi.nlm.nih.gov/gene/?term=9141 TFAR19 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025573 91433 RCCD1 http://www.ncbi.nlm.nih.gov/gene/?term=91433 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025574 91433 RCCD1 http://www.ncbi.nlm.nih.gov/gene/?term=91433 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025575 9143 SYNGR3 http://www.ncbi.nlm.nih.gov/gene/?term=9143 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025576 91445 RNF185 http://www.ncbi.nlm.nih.gov/gene/?term=91445 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025577 9144 SYNGR2 http://www.ncbi.nlm.nih.gov/gene/?term=9144 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025578 91452 ACBD5 http://www.ncbi.nlm.nih.gov/gene/?term=91452 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025579 9145 SYNGR1 http://www.ncbi.nlm.nih.gov/gene/?term=9145 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025580 9146 HGS http://www.ncbi.nlm.nih.gov/gene/?term=9146 HRS mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025581 9146 HGS http://www.ncbi.nlm.nih.gov/gene/?term=9146 HRS mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025582 9146 HGS http://www.ncbi.nlm.nih.gov/gene/?term=9146 HRS mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025583 9147 NEMF http://www.ncbi.nlm.nih.gov/gene/?term=9147 "NY-CO-1, SDCCAG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025584 9153 SLC28A2 http://www.ncbi.nlm.nih.gov/gene/?term=9153 "CNT2, HCNT2, HsT17153, SPNT1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025585 9153 SLC28A2 http://www.ncbi.nlm.nih.gov/gene/?term=9153 "CNT2, HCNT2, HsT17153, SPNT1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025586 91544 UBXN11 http://www.ncbi.nlm.nih.gov/gene/?term=91544 "COA-1, PP2243, SOC, SOCI, UBXD5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025587 9154 SLC28A1 http://www.ncbi.nlm.nih.gov/gene/?term=9154 "CNT1, HCNT1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025588 9156 EXO1 http://www.ncbi.nlm.nih.gov/gene/?term=9156 "HEX1, hExoI " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025589 91574 C12orf65 http://www.ncbi.nlm.nih.gov/gene/?term=91574 "COXPD7, SPG55 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025590 91582 RPS19BP1 http://www.ncbi.nlm.nih.gov/gene/?term=91582 "AROS, S19BP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025591 9158 FIBP http://www.ncbi.nlm.nih.gov/gene/?term=9158 "FGFIBP-1, FIBP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025592 9158 FIBP http://www.ncbi.nlm.nih.gov/gene/?term=9158 "FGFIBP, FIBP-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025593 9159 PCSK7 http://www.ncbi.nlm.nih.gov/gene/?term=9159 "LPC, PC7, PC8, SPC7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025594 9159 PCSK7 http://www.ncbi.nlm.nih.gov/gene/?term=9159 "LPC, PC7, PC8, SPC7 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025595 915 CD3D http://www.ncbi.nlm.nih.gov/gene/?term=915 "CD3-DELTA, IMD19, T3D " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025596 91603 ZNF830 http://www.ncbi.nlm.nih.gov/gene/?term=91603 "CCDC16, OMCG1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025597 91607 SLFN11 http://www.ncbi.nlm.nih.gov/gene/?term=91607 SLFN8/9 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025598 91607 SLFN11 http://www.ncbi.nlm.nih.gov/gene/?term=91607 SLFN8/9 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025599 91612 CHURC1 http://www.ncbi.nlm.nih.gov/gene/?term=91612 "C14orf52, My015, chch " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025600 91614 DEPDC7 http://www.ncbi.nlm.nih.gov/gene/?term=91614 "TR2, dJ85M6.4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025601 91647 ATPAF2 http://www.ncbi.nlm.nih.gov/gene/?term=91647 "ATP12, ATP12p, LP3663, MC5DN1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025602 91647 ATPAF2 http://www.ncbi.nlm.nih.gov/gene/?term=91647 "ATP12, ATP12p, LP3663, MC5DN1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025603 9164923 RDN18-1 http://www.ncbi.nlm.nih.gov/gene/?term=9164923 RDN18-1 rRNA Saccharomyces cerevisiae 17339339 Endoplasmic reticulum Yeast RT-PCR "Importantly, mRNAs encoding Sec4, Cdc42, Sro7, and Snc1 were specifically enriched in the ER fraction, along with ASH1 mRNA (Fig. 9B), which was shown to be enriched on the ER (18). mRNAs encoding RDN18, a ribosomal rRNA, and TUB1 were found in both the ER and cytosolic fractions (Fig. 9B). " RLID00025604 9164923 RDN18-1 http://www.ncbi.nlm.nih.gov/gene/?term=9164923 RDN18-1 rRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00025605 9164932 RDN18-2 http://www.ncbi.nlm.nih.gov/gene/?term=9164932 RDN18-2 rRNA Saccharomyces cerevisiae 17339339 Cytosol Yeast RT-PCR "Importantly, mRNAs encoding Sec4, Cdc42, Sro7, and Snc1 were specifically enriched in the ER fraction, along with ASH1 mRNA (Fig. 9B), which was shown to be enriched on the ER (18). mRNAs encoding RDN18, a ribosomal rRNA, and TUB1 were found in both the ER and cytosolic fractions (Fig. 9B). " RLID00025606 9164932 RDN18-2 http://www.ncbi.nlm.nih.gov/gene/?term=9164932 RDN18-2 rRNA Saccharomyces cerevisiae 23904265 Cytosol Yeast RT-PCR "Figure 2: mSMPs cofractionate with ER in WT cells. (A) Fractionation of lysates into ER (microsomal) and cytosolic fractions. WT yeast were lysed and subjected to sucrose density gradient centrifugation as described in Materials and Methods. Aliquots from the different fractions obtained through centrifugation were subjected to SDS–PAGE and detected in blots with antibodies against an ER marker, dolichol phosphate mannose (anti-Dpm1) synthase, or a cytosolic marker, phosphoglycerate kinase (anti-PGK1). Note lack of overlap between markers in the different fractions. (B) Distribution of mSMPs. Total mRNA isolated from the fractions (ER or cytosol [Cyt]) obtained using density gradient centrifugation was subjected to DNase I treatment and RT-PCR with oligonucleotide pairs specific to each mSMP. Genomic DNA served as a positive control for the PCR (Genomic), and RT without RNA template served as a negative control (�. PCR amplification of RNA from the ER and cytosolic fractions without reverse transcription (–RT) served as controls to detect DNA contamination. PCR amplification of RNA from the ER and cytosolic fractions with reverse transcription (+RT) is shown in duplicate. Samples were electrophoresed on agarose gels and documented by ethidium bromide labeling. (C) Distribution of an mRNA encoding a cytosolic protein. Same as in B except that an oligonucleotide pair specific to FSH3 was used. (D) Distribution of mRNAs not encoding mSMPs. Same as in B except that oligonucleotide pairs specific to mRNAs encoding proteins not translocated into the ER, but instead associated either with the cytosolic leaflet of the secretory pathway (SAR1, SEC9, SRO7, YKT6, YPT1) or ribosome (RDN18) were used. Data are collected from Figure 2. " RLID00025607 91661 ZNF765 http://www.ncbi.nlm.nih.gov/gene/?term=91661 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025608 91661 ZNF765 http://www.ncbi.nlm.nih.gov/gene/?term=91661 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025609 91663 MYADM http://www.ncbi.nlm.nih.gov/gene/?term=91663 SB135 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025610 91663 MYADM http://www.ncbi.nlm.nih.gov/gene/?term=91663 SB135 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025611 91663 MYADM http://www.ncbi.nlm.nih.gov/gene/?term=91663 SB135 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025612 9166 EBAG9 http://www.ncbi.nlm.nih.gov/gene/?term=9166 "EB9, PDAF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025613 9167 COX7A2L http://www.ncbi.nlm.nih.gov/gene/?term=9167 "COX7AR, COX7RP, EB1, SIG81 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025614 9167 COX7A2L http://www.ncbi.nlm.nih.gov/gene/?term=9167 "COX7AR, COX7RP, EB1, SIG81 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025615 91689 SMDT1 http://www.ncbi.nlm.nih.gov/gene/?term=91689 "C22orf32, DDDD, EMRE, dJ186O1.1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025616 91689 SMDT1 http://www.ncbi.nlm.nih.gov/gene/?term=91689 "C22orf32, DDDD, EMRE, dJ186O1.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025617 9168 TMSB10 http://www.ncbi.nlm.nih.gov/gene/?term=9168 "MIG12, TB10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025618 9168 TMSB10 http://www.ncbi.nlm.nih.gov/gene/?term=9168 "MIG12, TB10 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025619 9168 TMSB10 http://www.ncbi.nlm.nih.gov/gene/?term=9168 "MIG12, TB10 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025620 9168 TMSB10 http://www.ncbi.nlm.nih.gov/gene/?term=9168 "MIG12, TB10 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025621 9169 SCAF11 http://www.ncbi.nlm.nih.gov/gene/?term=9169 "CASP11, SFRS2IP, SIP1, SRRP129, SRSF2IP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025622 9169 SCAF11 http://www.ncbi.nlm.nih.gov/gene/?term=9169 "CASP11, SFRS2IP, SIP1, SRRP129, SRSF2IP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025623 91703 ACY3 http://www.ncbi.nlm.nih.gov/gene/?term=91703 "ACY-3, HCBP1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025624 9170 LPAR2 http://www.ncbi.nlm.nih.gov/gene/?term=9170 "EDG-4, EDG4, LPA-2, LPA2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025625 9170 LPAR2 http://www.ncbi.nlm.nih.gov/gene/?term=9170 "EDG-4, EDG4, LPA-2, LPA2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025626 91734 IDI2 http://www.ncbi.nlm.nih.gov/gene/?term=91734 IPPI2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025627 9173 IL1RL1 http://www.ncbi.nlm.nih.gov/gene/?term=9173 "DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025628 91746 YTHDC1 http://www.ncbi.nlm.nih.gov/gene/?term=91746 "YT521, YT521-B " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025629 91746 YTHDC1 http://www.ncbi.nlm.nih.gov/gene/?term=91746 "YT521, YT521-B " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025630 91748 ELMSAN1 http://www.ncbi.nlm.nih.gov/gene/?term=91748 "C14orf117, C14orf43, LSR68, MIDEAS, c14_5541 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025631 91748 ELMSAN1 http://www.ncbi.nlm.nih.gov/gene/?term=91748 "C14orf117, C14orf43, LSR68, MIDEAS, c14_5541 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025632 91748 ELMSAN1 http://www.ncbi.nlm.nih.gov/gene/?term=91748 "C14orf117, C14orf43, LSR68, MIDEAS, c14_5541 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025633 91749 MFSD4B http://www.ncbi.nlm.nih.gov/gene/?term=91749 "KIAA1919, NaGLT1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025634 91749 MFSD4B http://www.ncbi.nlm.nih.gov/gene/?term=91749 "KIAA1919, NaGLT1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025635 91754 NEK9 http://www.ncbi.nlm.nih.gov/gene/?term=91754 "NERCC, NERCC1, Nek8 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025636 91754 NEK9 http://www.ncbi.nlm.nih.gov/gene/?term=91754 "NERCC, NERCC1, Nek8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025637 91754 NEK9 http://www.ncbi.nlm.nih.gov/gene/?term=91754 "NERCC, NERCC1, Nek8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025638 9175 MAP3K13 http://www.ncbi.nlm.nih.gov/gene/?term=9175 "LZK, MEKK13, MLK " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025639 9175 MAP3K13 http://www.ncbi.nlm.nih.gov/gene/?term=9175 "LZK, MEKK13, MLK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025640 91775 NXPE3 http://www.ncbi.nlm.nih.gov/gene/?term=91775 "FAM55C, MST115, MSTP115 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025641 91775 NXPE3 http://www.ncbi.nlm.nih.gov/gene/?term=91775 "FAM55C, MST115, MSTP115 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025642 91775 NXPE3 http://www.ncbi.nlm.nih.gov/gene/?term=91775 "FAM55C, MST115, MSTP115 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025643 91782 CHMP7 http://www.ncbi.nlm.nih.gov/gene/?term=91782 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025644 9179 AP4M1 http://www.ncbi.nlm.nih.gov/gene/?term=9179 "CPSQ3, MU-4, MU-ARP2, SPG50 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025645 917 CD3G http://www.ncbi.nlm.nih.gov/gene/?term=917 "CD3-GAMMA, IMD17, T3G " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025646 91807 MYLK3 http://www.ncbi.nlm.nih.gov/gene/?term=91807 "MLCK, MLCK2, caMLCK " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025647 91807 MYLK3 http://www.ncbi.nlm.nih.gov/gene/?term=91807 "MLCK, MLCK2, caMLCK " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025648 9181 ARHGEF2 http://www.ncbi.nlm.nih.gov/gene/?term=9181 "GEF, GEF-H1, GEFH1, LFP40, P40 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025649 91833 WDR20 http://www.ncbi.nlm.nih.gov/gene/?term=91833 DMR mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025650 9183 ZW10 http://www.ncbi.nlm.nih.gov/gene/?term=9183 "HZW10, KNTC1AP " mRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00025651 9183 ZW10 http://www.ncbi.nlm.nih.gov/gene/?term=9183 "HZW10, KNTC1AP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025652 9183 ZW10 http://www.ncbi.nlm.nih.gov/gene/?term=9183 "HZW10, KNTC1AP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025653 9183 ZW10 http://www.ncbi.nlm.nih.gov/gene/?term=9183 "HZW10, KNTC1AP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025654 9184 BUB3 http://www.ncbi.nlm.nih.gov/gene/?term=9184 "BUB3L, hBUB3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025655 9184 BUB3 http://www.ncbi.nlm.nih.gov/gene/?term=9184 "BUB3L, hBUB3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025656 9185 REPS2 http://www.ncbi.nlm.nih.gov/gene/?term=9185 POB1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025657 9185 REPS2 http://www.ncbi.nlm.nih.gov/gene/?term=9185 POB1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025658 91862 MARVELD3 http://www.ncbi.nlm.nih.gov/gene/?term=91862 "MARVD3, MRVLDC3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025659 91875 TTC5 http://www.ncbi.nlm.nih.gov/gene/?term=91875 Strap mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025660 91875 TTC5 http://www.ncbi.nlm.nih.gov/gene/?term=91875 Strap mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025661 91875 TTC5 http://www.ncbi.nlm.nih.gov/gene/?term=91875 Strap mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025662 9187 SLC24A1 http://www.ncbi.nlm.nih.gov/gene/?term=9187 "CSNB1D, HsT17412, NCKX, NCKX1, RODX " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025663 9188 DDX21 http://www.ncbi.nlm.nih.gov/gene/?term=9188 "GUA, GURDB, RH-II/GU, RH-II/GuA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025664 9188 DDX21 http://www.ncbi.nlm.nih.gov/gene/?term=9188 "GUA, GURDB, RH-II/GU, RH-II/GuA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025665 91893 FDXACB1 http://www.ncbi.nlm.nih.gov/gene/?term=91893 hCG_2033039 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025666 91893 FDXACB1 http://www.ncbi.nlm.nih.gov/gene/?term=91893 hCG_2033039 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025667 91893 FDXACB1 http://www.ncbi.nlm.nih.gov/gene/?term=91893 hCG_2033039 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025668 9189 ZBED1 http://www.ncbi.nlm.nih.gov/gene/?term=9189 "ALTE, DREF, TRAMP, hDREF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025669 9191 DEDD http://www.ncbi.nlm.nih.gov/gene/?term=9191 "CASP8IP11, DEFT, FLDED1, KE05, DEDD " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025670 9191 DEDD http://www.ncbi.nlm.nih.gov/gene/?term=9191 "CASP8IP1, DEDD1, DEFT, FLDED1, KE05 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025671 91942 NDUFAF2 http://www.ncbi.nlm.nih.gov/gene/?term=91942 "B17.2L, MMTN, NDUFA12L, mimitin " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025672 91949 COG7 http://www.ncbi.nlm.nih.gov/gene/?term=91949 CDG2E mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025673 91966 CXorf40A http://www.ncbi.nlm.nih.gov/gene/?term=91966 "CXorf40, EOLA1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025674 9197 SLC33A1 http://www.ncbi.nlm.nih.gov/gene/?term=9197 "ACATN, AT-1, AT1, CCHLND, SPG42 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025675 9197 SLC33A1 http://www.ncbi.nlm.nih.gov/gene/?term=9197 "ACATN, AT-1, AT1, CCHLND, SPG42 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025676 9197 SLC33A1 http://www.ncbi.nlm.nih.gov/gene/?term=9197 "ACATN, AT-1, AT1, CCHLND, SPG42 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025677 91 ACVR1B http://www.ncbi.nlm.nih.gov/gene/?term=91 "ACTRIB, ACVRLK4, ALK4, SKR2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025678 9200 HACD1 http://www.ncbi.nlm.nih.gov/gene/?term=9200 "CAP, PTPLA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025679 92014 SLC25A51 http://www.ncbi.nlm.nih.gov/gene/?term=92014 "CG7943, MCART1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025680 9201 DCLK1 http://www.ncbi.nlm.nih.gov/gene/?term=9201 "CL1, CLICK1, DCAMKL1, DCDC3A, DCLK " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025681 9202 ZMYM4 http://www.ncbi.nlm.nih.gov/gene/?term=9202 "CDIR, MYM, ZNF198L3, ZNF262 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025682 9203 ZMYM3 http://www.ncbi.nlm.nih.gov/gene/?term=9203 "DXS6673E, MYM, XFIM, ZNF198L2, ZNF261 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025683 9204 ZMYM6 http://www.ncbi.nlm.nih.gov/gene/?term=9204 "Buster2, MYM, ZBED7, ZNF198L4, ZNF258 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025684 9204 ZMYM6 http://www.ncbi.nlm.nih.gov/gene/?term=9204 "Buster2, MYM, ZBED7, ZNF198L4, ZNF258 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025685 9204 ZMYM6 http://www.ncbi.nlm.nih.gov/gene/?term=9204 "Buster2, MYM, ZBED7, ZNF198L4, ZNF258 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025686 92070 CTBP1-AS2 http://www.ncbi.nlm.nih.gov/gene/?term=92070 "C4orf42, CTBP1-AS1 " lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025687 9208 LRRFIP1 http://www.ncbi.nlm.nih.gov/gene/?term=9208 "FLAP-1, FLAP1, FLIIAP1, GCF-2, GCF2, HUFI-1, TRIP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025688 9208 LRRFIP1 http://www.ncbi.nlm.nih.gov/gene/?term=9208 "FLAP-1, FLAP1, FLIIAP1, GCF-2, GCF2, HUFI-1, TRIP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025689 92092 ZC3HAV1L http://www.ncbi.nlm.nih.gov/gene/?term=92092 C7orf39 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025690 920 CD4 http://www.ncbi.nlm.nih.gov/gene/?term=920 CD4mut mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025691 92105 INTS4 http://www.ncbi.nlm.nih.gov/gene/?term=92105 "INT4, MST093 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025692 92106 OXNAD1 http://www.ncbi.nlm.nih.gov/gene/?term=92106 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025693 92126 DSEL http://www.ncbi.nlm.nih.gov/gene/?term=92126 C18orf4 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025694 92126 DSEL http://www.ncbi.nlm.nih.gov/gene/?term=92126 C18orf4 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025695 9212 AURKB http://www.ncbi.nlm.nih.gov/gene/?term=9212 "AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5, aurkb-sv1, aurkb-sv2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025696 9212 AURKB http://www.ncbi.nlm.nih.gov/gene/?term=9212 "AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5, aurkb-sv1, aurkb-sv2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025697 9213 XPR1 http://www.ncbi.nlm.nih.gov/gene/?term=9213 "IBGC6, SYG1, X3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025698 9213 XPR1 http://www.ncbi.nlm.nih.gov/gene/?term=9213 "IBGC6, SYG1, X3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025699 92140 MTDH http://www.ncbi.nlm.nih.gov/gene/?term=92140 "3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025700 92140 MTDH http://www.ncbi.nlm.nih.gov/gene/?term=92140 "3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025701 9215 LARGE http://www.ncbi.nlm.nih.gov/gene/?term=9215 "MDC1D, MDDGA6, MDDGB6 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025702 92170 MTG1 http://www.ncbi.nlm.nih.gov/gene/?term=92170 "GTP, GTPBP7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025703 9217 VAPB http://www.ncbi.nlm.nih.gov/gene/?term=9217 "ALS8, VAMP-B, VAP-B " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025704 9217 VAPB http://www.ncbi.nlm.nih.gov/gene/?term=9217 "ALS8, VAMP-B, VAP-B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025705 92181 UBTD2 http://www.ncbi.nlm.nih.gov/gene/?term=92181 DCUBP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025706 92181 UBTD2 http://www.ncbi.nlm.nih.gov/gene/?term=92181 DCUBP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025707 9218 VAPA http://www.ncbi.nlm.nih.gov/gene/?term=9218 "VAP-33, VAP-A, VAP33, hVAP-33 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025708 9218 VAPA http://www.ncbi.nlm.nih.gov/gene/?term=9218 "VAP-33, VAP-A, VAP33, hVAP-33 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025709 9218 VAPA http://www.ncbi.nlm.nih.gov/gene/?term=9218 "VAP-33, VAP-A, VAP33, hVAP-33 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025710 9218 VAPA http://www.ncbi.nlm.nih.gov/gene/?term=9218 "VAP-33, VAP-A, VAP33, hVAP-33 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025711 9219 MTA2 http://www.ncbi.nlm.nih.gov/gene/?term=9219 "MTA1L1, PID " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025712 9220 TIAF1 http://www.ncbi.nlm.nih.gov/gene/?term=9220 "MAJN, SPR210 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025713 9221 NOLC1 http://www.ncbi.nlm.nih.gov/gene/?term=9221 "NOPP130, NOPP140, NS5ATP13, P130 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025714 92235 DUSP27 http://www.ncbi.nlm.nih.gov/gene/?term=92235 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025715 9223 MAGI1 http://www.ncbi.nlm.nih.gov/gene/?term=9223 "AIP-3, AIP3, BAIAP1, BAP-1, BAP1, MAGI-1, Magi1d, TNRC19, WWP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025716 92249 LINC01278 http://www.ncbi.nlm.nih.gov/gene/?term=92249 lncRNA Homo sapiens 25630241 Cytoplasm Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00025717 92249 LINC01278 http://www.ncbi.nlm.nih.gov/gene/?term=92249 lncRNA Homo sapiens 25630241 Nucleus Hela cell qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00025718 92249 LINC01278 http://www.ncbi.nlm.nih.gov/gene/?term=92249 lncRNA Homo sapiens 25630241 Nucleus Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00025719 92259 MRPS36 http://www.ncbi.nlm.nih.gov/gene/?term=92259 "DC47, MRP-S36 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025720 92270 ATP6AP1L http://www.ncbi.nlm.nih.gov/gene/?term=92270 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025721 9227 LRAT http://www.ncbi.nlm.nih.gov/gene/?term=9227 LCA14 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025722 9227 LRAT http://www.ncbi.nlm.nih.gov/gene/?term=9227 LCA14 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025723 92283 ZNF461 http://www.ncbi.nlm.nih.gov/gene/?term=92283 "GIOT-1, GIOT1, HZF28 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025724 92283 ZNF461 http://www.ncbi.nlm.nih.gov/gene/?term=92283 "GIOT-1, GIOT1, HZF28 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025725 92305 TMEM129 http://www.ncbi.nlm.nih.gov/gene/?term=92305 D4S2561E mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025726 92305 TMEM129 http://www.ncbi.nlm.nih.gov/gene/?term=92305 D4S2561E mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025727 9230 RAB11B http://www.ncbi.nlm.nih.gov/gene/?term=9230 H-YPT3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025728 9230 RAB11B http://www.ncbi.nlm.nih.gov/gene/?term=9230 H-YPT3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025729 9231 DLG5 http://www.ncbi.nlm.nih.gov/gene/?term=9231 "LP-DLG, P-DLG5, PDLG " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025730 9231 DLG5 http://www.ncbi.nlm.nih.gov/gene/?term=9231 "LP-DLG, P-DLG5, PDLG " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025731 9231 DLG5 http://www.ncbi.nlm.nih.gov/gene/?term=9231 "LP-DLG, P-DLG5, PDLG " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025732 9231 DLG5 http://www.ncbi.nlm.nih.gov/gene/?term=9231 "LP-DLG, P-DLG5, PDLG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025733 9232 PTTG1 http://www.ncbi.nlm.nih.gov/gene/?term=9232 "EAP1, HPTTG, PTTG, TUTR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025734 9232 PTTG1 http://www.ncbi.nlm.nih.gov/gene/?term=9232 "EAP1, HPTTG, PTTG, TUTR1 " mRNA Homo sapiens 25627474 Cytoplasm AGS cell|SGC7901 cell qRT-PCR "PTTG1 expression was nuclear and cytoplasmic, with higher cytoplasmic expression. PTTG1 was expressed in the nuclear and cytoplasmic fractions. These results suggest that PTTG1 exhibits nuclear and cytoplasmic expression, with slightly higher cytoplasmic expression. " RLID00025735 9232 PTTG1 http://www.ncbi.nlm.nih.gov/gene/?term=9232 "EAP1, HPTTG, PTTG, TUTR1 " mRNA Homo sapiens 25627474 Nucleus AGS cell|SGC7901 cell qRT-PCR "PTTG1 expression was nuclear and cytoplasmic, with higher cytoplasmic expression. PTTG1 was expressed in the nuclear and cytoplasmic fractions. These results suggest that PTTG1 exhibits nuclear and cytoplasmic expression, with slightly higher cytoplasmic expression. " RLID00025736 9232 PTTG1 http://www.ncbi.nlm.nih.gov/gene/?term=9232 "EAP1, HPTTG, PTTG, TUTR1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025737 9232 PTTG1 http://www.ncbi.nlm.nih.gov/gene/?term=9232 "EAP1, HPTTG, PTTG, TUTR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025738 92335 STRADA http://www.ncbi.nlm.nih.gov/gene/?term=92335 "LYK5, NY-BR-96, PMSE, STRAD, Stlk " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025739 92342 METTL18 http://www.ncbi.nlm.nih.gov/gene/?term=92342 "AsTP2, C1orf156, HPM1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025740 92344 GORAB http://www.ncbi.nlm.nih.gov/gene/?term=92344 "GO, NTKLBP1, SCYL1BP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025741 92359 CRB3 http://www.ncbi.nlm.nih.gov/gene/?term=92359 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025742 9235 IL32 http://www.ncbi.nlm.nih.gov/gene/?term=9235 "IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025743 9235 IL32 http://www.ncbi.nlm.nih.gov/gene/?term=9235 "IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025744 9236 CCPG1 http://www.ncbi.nlm.nih.gov/gene/?term=9236 CPR8 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025745 92370 PXYLP1 http://www.ncbi.nlm.nih.gov/gene/?term=92370 "ACPL2, HEL124, XYLP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025746 9238 TBRG4 http://www.ncbi.nlm.nih.gov/gene/?term=9238 "CPR2, FASTKD4 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025747 9238 TBRG4 http://www.ncbi.nlm.nih.gov/gene/?term=9238 "CPR2, FASTKD4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025748 92399 MRRF http://www.ncbi.nlm.nih.gov/gene/?term=92399 "MRFF, MTRRF, RRF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025749 92400 RBM18 http://www.ncbi.nlm.nih.gov/gene/?term=92400 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025750 92421 CHMP4C http://www.ncbi.nlm.nih.gov/gene/?term=92421 "SNF7-3, Shax3, VPS32C " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025751 92421 CHMP4C http://www.ncbi.nlm.nih.gov/gene/?term=92421 "SNF7-3, Shax3, VPS32C " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025752 92421 CHMP4C http://www.ncbi.nlm.nih.gov/gene/?term=92421 "SNF7-3, Shax3, VPS32C " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025753 9246 UBE2L6 http://www.ncbi.nlm.nih.gov/gene/?term=9246 "RIG-B, UBCH8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025754 9246 UBE2L6 http://www.ncbi.nlm.nih.gov/gene/?term=9246 "RIG-B, UBCH8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025755 92482 BBIP1 http://www.ncbi.nlm.nih.gov/gene/?term=92482 "BBIP10, BBS18, NCRNA00081, bA348N5.3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025756 9249 DHRS3 http://www.ncbi.nlm.nih.gov/gene/?term=9249 "DD83.1, RDH17, Rsdr1, SDR1, SDR16C1, retSDR1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025757 92521 SPECC1 http://www.ncbi.nlm.nih.gov/gene/?term=92521 "CYTSB, HCMOGT-1, HCMOGT1, NSP " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025758 92521 SPECC1 http://www.ncbi.nlm.nih.gov/gene/?term=92521 "CYTSB, HCMOGT-1, HCMOGT1, NSP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025759 9252 RPS6KA5 http://www.ncbi.nlm.nih.gov/gene/?term=9252 "MSK1, MSPK1, RLPK " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025760 9252 RPS6KA5 http://www.ncbi.nlm.nih.gov/gene/?term=9252 "MSK1, MSPK1, RLPK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025761 9254 CACNA2D2 http://www.ncbi.nlm.nih.gov/gene/?term=9254 CACNA2D mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025762 9255 AIMP1 http://www.ncbi.nlm.nih.gov/gene/?term=9255 "EMAP2, EMAPII, HLD3, SCYE1, p43 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025763 9255 AIMP1 http://www.ncbi.nlm.nih.gov/gene/?term=9255 "EMAP2, EMAPII, HLD3, SCYE1, p43 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025764 92579 G6PC3 http://www.ncbi.nlm.nih.gov/gene/?term=92579 "SCN4, UGRP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025765 9258 MFHAS1 http://www.ncbi.nlm.nih.gov/gene/?term=9258 "LRRC65, MASL1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025766 92591 ASB16 http://www.ncbi.nlm.nih.gov/gene/?term=92591 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025767 92591 ASB16 http://www.ncbi.nlm.nih.gov/gene/?term=92591 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025768 92595 ZNF764 http://www.ncbi.nlm.nih.gov/gene/?term=92595 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025769 92595 ZNF764 http://www.ncbi.nlm.nih.gov/gene/?term=92595 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025770 92595 ZNF764 http://www.ncbi.nlm.nih.gov/gene/?term=92595 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025771 92597 MOB1B http://www.ncbi.nlm.nih.gov/gene/?term=92597 "MATS2, MOB4A, MOBKL1A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025772 92597 MOB1B http://www.ncbi.nlm.nih.gov/gene/?term=92597 "MATS2, MOB4A, MOBKL1A " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025773 92597 MOB1B http://www.ncbi.nlm.nih.gov/gene/?term=92597 "MATS2, MOB4A, MOBKL1A " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025774 92597 MOB1B http://www.ncbi.nlm.nih.gov/gene/?term=92597 "MATS2, MOB4A, MOBKL1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025775 92609 TIMM50 http://www.ncbi.nlm.nih.gov/gene/?term=92609 "TIM50, TIM50L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025776 9260 PDLIM7 http://www.ncbi.nlm.nih.gov/gene/?term=9260 "LMP1, LMP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025777 9261 MAPKAPK2 http://www.ncbi.nlm.nih.gov/gene/?term=9261 "MAPKAP-K2, MK-2, MK2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025778 9261 MAPKAPK2 http://www.ncbi.nlm.nih.gov/gene/?term=9261 "MAPKAP-K2, MK-2, MK2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025779 9262 STK17B http://www.ncbi.nlm.nih.gov/gene/?term=9262 DRAK2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025780 9263 STK17A http://www.ncbi.nlm.nih.gov/gene/?term=9263 DRAK1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025781 9263 STK17A http://www.ncbi.nlm.nih.gov/gene/?term=9263 DRAK1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025782 92659 MAFG-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=92659 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025783 9266 CYTH2 http://www.ncbi.nlm.nih.gov/gene/?term=9266 "ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025784 9266 CYTH2 http://www.ncbi.nlm.nih.gov/gene/?term=9266 "ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025785 9266 CYTH2 http://www.ncbi.nlm.nih.gov/gene/?term=9266 "ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025786 9266 CYTH2 http://www.ncbi.nlm.nih.gov/gene/?term=9266 "ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025787 92675 DTD1 http://www.ncbi.nlm.nih.gov/gene/?term=92675 "C20orf88, DUE-B, DUEB, HARS2, pqn-68 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025788 9267 CYTH1 http://www.ncbi.nlm.nih.gov/gene/?term=9267 "B2-1, CYTOHESIN-1, D17S811E, PSCD1, SEC7 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025789 9267 CYTH1 http://www.ncbi.nlm.nih.gov/gene/?term=9267 "B2-1, CYTOHESIN-1, D17S811E, PSCD1, SEC7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025790 92689 FAM114A1 http://www.ncbi.nlm.nih.gov/gene/?term=92689 Noxp20 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025791 92691 TMEM169 http://www.ncbi.nlm.nih.gov/gene/?term=92691 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025792 92691 TMEM169 http://www.ncbi.nlm.nih.gov/gene/?term=92691 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025793 92691 TMEM169 http://www.ncbi.nlm.nih.gov/gene/?term=92691 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025794 926 CD8B http://www.ncbi.nlm.nih.gov/gene/?term=926 "CD8B1, LEU2, LY3, LYT3, P37 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025795 92703 TMEM183A http://www.ncbi.nlm.nih.gov/gene/?term=92703 C1orf37 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025796 92703 TMEM183A http://www.ncbi.nlm.nih.gov/gene/?term=92703 C1orf37 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025797 9270 ITGB1BP1 http://www.ncbi.nlm.nih.gov/gene/?term=9270 "ICAP-1A, ICAP-1B, ICAP-1alpha, ICAP1, ICAP1A, ICAP1B " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025798 9270 ITGB1BP1 http://www.ncbi.nlm.nih.gov/gene/?term=9270 "ICAP-1A, ICAP-1B, ICAP-1alpha, ICAP1, ICAP1A, ICAP1B " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025799 9270 ITGB1BP1 http://www.ncbi.nlm.nih.gov/gene/?term=9270 "ICAP-1A, ICAP-1B, ICAP-1alpha, ICAP1, ICAP1A, ICAP1B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025800 92714 ARRDC1 http://www.ncbi.nlm.nih.gov/gene/?term=92714 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025801 9271 PIWIL1 http://www.ncbi.nlm.nih.gov/gene/?term=9271 "CT80.1, HIWI, MIWI, PIWI " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025802 9274 BCL7C http://www.ncbi.nlm.nih.gov/gene/?term=9274 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025803 9275 BCL7B http://www.ncbi.nlm.nih.gov/gene/?term=9275 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025804 9275 BCL7B http://www.ncbi.nlm.nih.gov/gene/?term=9275 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025805 9276 COPB2 http://www.ncbi.nlm.nih.gov/gene/?term=9276 beta'-COP mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025806 9276 COPB2 http://www.ncbi.nlm.nih.gov/gene/?term=9276 beta'-COP mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025807 9276 COPB2 http://www.ncbi.nlm.nih.gov/gene/?term=9276 beta'-COP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025808 9277 WDR46 http://www.ncbi.nlm.nih.gov/gene/?term=9277 "BING4, C6orf11, FP221, UTP7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025809 9278 ZBTB22 http://www.ncbi.nlm.nih.gov/gene/?term=9278 "BING1A, ZNF297, ZNF297A, fru, fruitless, ZBTB22 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025810 9278 ZBTB22 http://www.ncbi.nlm.nih.gov/gene/?term=9278 "BING1, ZBTB22A, ZNF297, ZNF297A, fru, fruitless " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025811 92799 SHKBP1 http://www.ncbi.nlm.nih.gov/gene/?term=92799 "PP203, Sb1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025812 92799 SHKBP1 http://www.ncbi.nlm.nih.gov/gene/?term=92799 "PP203, Sb1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025813 92815 HIST3H2A http://www.ncbi.nlm.nih.gov/gene/?term=92815 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025814 92815 HIST3H2A http://www.ncbi.nlm.nih.gov/gene/?term=92815 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025815 9282 MED14 http://www.ncbi.nlm.nih.gov/gene/?term=9282 "CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, RGR1, TRAP170 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025816 9283 GPR37L1 http://www.ncbi.nlm.nih.gov/gene/?term=9283 "ET(B)R-LP-2, ETBR-LP-2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025817 9283 GPR37L1 http://www.ncbi.nlm.nih.gov/gene/?term=9283 "ET(B)R-LP-2, ETBR-LP-2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025818 92840 REEP6 http://www.ncbi.nlm.nih.gov/gene/?term=92840 "C19orf32, DP1L1, TB2L1, Yip2f " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025819 92840 REEP6 http://www.ncbi.nlm.nih.gov/gene/?term=92840 "C19orf32, DP1L1, TB2L1, Yip2f " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025820 92856 IMP4 http://www.ncbi.nlm.nih.gov/gene/?term=92856 BXDC4 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025821 92856 IMP4 http://www.ncbi.nlm.nih.gov/gene/?term=92856 BXDC4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025822 9289 ADGRG1 http://www.ncbi.nlm.nih.gov/gene/?term=9289 "BFPP, BPPR, GPR56, TM7LN4, TM7XN1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025823 9289 ADGRG1 http://www.ncbi.nlm.nih.gov/gene/?term=9289 "BFPP, BPPR, GPR56, TM7LN4, TM7XN1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025824 928 CD9 http://www.ncbi.nlm.nih.gov/gene/?term=928 "BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025825 928 CD9 http://www.ncbi.nlm.nih.gov/gene/?term=928 "BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025826 928 CD9 http://www.ncbi.nlm.nih.gov/gene/?term=928 "BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025827 92906 HNRNPLL http://www.ncbi.nlm.nih.gov/gene/?term=92906 "HNRPLL, SRRF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025828 92906 HNRNPLL http://www.ncbi.nlm.nih.gov/gene/?term=92906 "HNRPLL, SRRF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025829 92912 UBE2Q2 http://www.ncbi.nlm.nih.gov/gene/?term=92912 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025830 92935 MARS2 http://www.ncbi.nlm.nih.gov/gene/?term=92935 "COXPD25, MetRS, mtMetRS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025831 92949 ADAMTSL1 http://www.ncbi.nlm.nih.gov/gene/?term=92949 "ADAMTSL-1, ADAMTSR1, C9orf94, PUNCTIN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025832 92949 ADAMTSL1 http://www.ncbi.nlm.nih.gov/gene/?term=92949 "ADAMTSL-1, ADAMTSR1, C9orf94, PUNCTIN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025833 9294 S1PR2 http://www.ncbi.nlm.nih.gov/gene/?term=9294 "AGR16, DFNB68, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025834 9294 S1PR2 http://www.ncbi.nlm.nih.gov/gene/?term=9294 "AGR16, DFNB68, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025835 9294 S1PR2 http://www.ncbi.nlm.nih.gov/gene/?term=9294 "AGR16, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025836 9295 SRSF11 http://www.ncbi.nlm.nih.gov/gene/?term=9295 "NET2, SFRS11, dJ677H15.2, p54 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025837 9295 SRSF11 http://www.ncbi.nlm.nih.gov/gene/?term=9295 "NET2, SFRS11, dJ677H15.2, p54 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025838 9296 ATP6V1F http://www.ncbi.nlm.nih.gov/gene/?term=9296 "ATP6S14, VATF, Vma7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025839 9296 ATP6V1F http://www.ncbi.nlm.nih.gov/gene/?term=9296 "ATP6S14, VATF, Vma7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025840 92979 MARCH9 http://www.ncbi.nlm.nih.gov/gene/?term=92979 "MARCH-IX, RNF179 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025841 9297 SNORD29 http://www.ncbi.nlm.nih.gov/gene/?term=9297 "RNU29, U29 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025842 9298 SNORD31 http://www.ncbi.nlm.nih.gov/gene/?term=9298 "RNU31A, U31, SNORD31 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00025843 9298 SNORD31 http://www.ncbi.nlm.nih.gov/gene/?term=9298 "RNU31A, U31, SNORD31 " snoRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "The most abundant snoRNA found in the serum exosomes were SNORD100, SNORD27 and SNORD31 (Supplementary file). The functions of these snoRNA species are largely unknown; however, they have been detected in myeloma. " RLID00025844 9298 SNORD31 http://www.ncbi.nlm.nih.gov/gene/?term=9298 "RNU31A, U31, SNORD31 " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00025845 9298 SNORD31 http://www.ncbi.nlm.nih.gov/gene/?term=9298 "RNU31A, U31, SNORD31 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00025846 9298 SNORD31 http://www.ncbi.nlm.nih.gov/gene/?term=9298 "RNU31A, U31, SNORD31 " snoRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00025847 9298 SNORD31 http://www.ncbi.nlm.nih.gov/gene/?term=9298 "RNU31A, U31, SNORD31 " snoRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 6. Ten Most Highly Expressed snoRNAs of Exosome I, Exosome II and W. Data are collected from Table 6. " RLID00025848 9298 SNORD31 http://www.ncbi.nlm.nih.gov/gene/?term=9298 "RNU31A, U31, SNORD31 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025849 9299 SNORD30 http://www.ncbi.nlm.nih.gov/gene/?term=9299 "RNU30, U30 " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00025850 9299 SNORD30 http://www.ncbi.nlm.nih.gov/gene/?term=9299 "RNU30, U30 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00025851 9299 SNORD30 http://www.ncbi.nlm.nih.gov/gene/?term=9299 "RNU30, U30 " snoRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 6. Ten Most Highly Expressed snoRNAs of Exosome I, Exosome II and W. Data are collected from Table 6. " RLID00025852 929 CD14 http://www.ncbi.nlm.nih.gov/gene/?term=929 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025853 92 ACVR2A http://www.ncbi.nlm.nih.gov/gene/?term=92 "ACTRII, ACVR2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025854 92 ACVR2A http://www.ncbi.nlm.nih.gov/gene/?term=92 "ACTRII, ACVR2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025855 9300 SNORD28 http://www.ncbi.nlm.nih.gov/gene/?term=9300 "RNU28A, U28, SNORD28 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025856 9300 SNORD28 http://www.ncbi.nlm.nih.gov/gene/?term=9300 "RNU28A, U28, SNORD28 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025857 9301 SNORD27 http://www.ncbi.nlm.nih.gov/gene/?term=9301 "RNU27, U27 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00025858 9301 SNORD27 http://www.ncbi.nlm.nih.gov/gene/?term=9301 "RNU27, U27 " snoRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "The most abundant snoRNA found in the serum exosomes were SNORD100, SNORD27 and SNORD31 (Supplementary file). The functions of these snoRNA species are largely unknown; however, they have been detected in myeloma. " RLID00025859 9301 SNORD27 http://www.ncbi.nlm.nih.gov/gene/?term=9301 "RNU27, U27 " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00025860 9301 SNORD27 http://www.ncbi.nlm.nih.gov/gene/?term=9301 "RNU27, U27 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00025861 9301 SNORD27 http://www.ncbi.nlm.nih.gov/gene/?term=9301 "RNU27, U27 " snoRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 6. Ten Most Highly Expressed snoRNAs of Exosome I, Exosome II and W. Data are collected from Table 6. " RLID00025862 9301 SNORD27 http://www.ncbi.nlm.nih.gov/gene/?term=9301 "RNU27, U27 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025863 9301 SNORD27 http://www.ncbi.nlm.nih.gov/gene/?term=9301 "RNU27, U27 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025864 9302 SNORD26 http://www.ncbi.nlm.nih.gov/gene/?term=9302 "RNU26, U26 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00025865 9302 SNORD26 http://www.ncbi.nlm.nih.gov/gene/?term=9302 "RNU26, U26 " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00025866 9302 SNORD26 http://www.ncbi.nlm.nih.gov/gene/?term=9302 "RNU26, U26 " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00025867 9302 SNORD26 http://www.ncbi.nlm.nih.gov/gene/?term=9302 "RNU26, U26 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025868 9303 SNORD25 http://www.ncbi.nlm.nih.gov/gene/?term=9303 "RNU25, U25 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00025869 9304 SNORD22 http://www.ncbi.nlm.nih.gov/gene/?term=9304 "RNU22, U22 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00025870 9304 SNORD22 http://www.ncbi.nlm.nih.gov/gene/?term=9304 "RNU22, U22 " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025871 9304 SNORD22 http://www.ncbi.nlm.nih.gov/gene/?term=9304 "RNU22, U22 " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025872 9306 SOCS6 http://www.ncbi.nlm.nih.gov/gene/?term=9306 "CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025873 9306 SOCS6 http://www.ncbi.nlm.nih.gov/gene/?term=9306 "CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025874 93081 TEX30 http://www.ncbi.nlm.nih.gov/gene/?term=93081 C13orf27 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025875 93099 DMKN http://www.ncbi.nlm.nih.gov/gene/?term=93099 "UNQ729, ZD52F10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025876 93100 NAPRT http://www.ncbi.nlm.nih.gov/gene/?term=93100 "NAPRT1, PP3856 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025877 93100 NAPRT http://www.ncbi.nlm.nih.gov/gene/?term=93100 "NAPRT1, PP3856 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025878 93109 TMEM44 http://www.ncbi.nlm.nih.gov/gene/?term=93109 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025879 93109 TMEM44 http://www.ncbi.nlm.nih.gov/gene/?term=93109 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025880 93145 OLFM2 http://www.ncbi.nlm.nih.gov/gene/?term=93145 "NOE2, NOELIN2, NOELIN2_V1, OlfC " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025881 9314 KLF4 http://www.ncbi.nlm.nih.gov/gene/?term=9314 "EZF, GKLF " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025882 9314 KLF4 http://www.ncbi.nlm.nih.gov/gene/?term=9314 "EZF, GKLF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025883 93183 PIGM http://www.ncbi.nlm.nih.gov/gene/?term=93183 GPI-MT-I mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025884 93183 PIGM http://www.ncbi.nlm.nih.gov/gene/?term=93183 GPI-MT-I mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025885 93183 PIGM http://www.ncbi.nlm.nih.gov/gene/?term=93183 GPI-MT-I mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025886 9318 COPS2 http://www.ncbi.nlm.nih.gov/gene/?term=9318 "ALIEN, CSN2, SGN2, TRIP15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025887 9318 COPS2 http://www.ncbi.nlm.nih.gov/gene/?term=9318 "ALIEN, CSN2, SGN2, TRIP15 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025888 9318 COPS2 http://www.ncbi.nlm.nih.gov/gene/?term=9318 "ALIEN, CSN2, SGN2, TRIP15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025889 93190 C1orf158 http://www.ncbi.nlm.nih.gov/gene/?term=93190 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025890 9319 TRIP13 http://www.ncbi.nlm.nih.gov/gene/?term=9319 16E1BP mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025891 9319 TRIP13 http://www.ncbi.nlm.nih.gov/gene/?term=9319 16E1BP mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025892 9320 TRIP12 http://www.ncbi.nlm.nih.gov/gene/?term=9320 "TRIP-12, ULF " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025893 9320 TRIP12 http://www.ncbi.nlm.nih.gov/gene/?term=9320 "TRIP-12, ULF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025894 93210 PGAP3 http://www.ncbi.nlm.nih.gov/gene/?term=93210 "AGLA546, CAB2, PERLD1, PP1498, hCOS16 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025895 9321 TRIP11 http://www.ncbi.nlm.nih.gov/gene/?term=9321 "ACG1A, CEV14, GMAP-210, GMAP210, TRIP-11, TRIP230 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025896 9322 TRIP10 http://www.ncbi.nlm.nih.gov/gene/?term=9322 "CIP4, HSTP, STOT, STP, TRIP-10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025897 9322 TRIP10 http://www.ncbi.nlm.nih.gov/gene/?term=9322 "CIP4, HSTP, STOT, STP, TRIP-10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025898 9324 HMGN3 http://www.ncbi.nlm.nih.gov/gene/?term=9324 "PNAS-24, PNAS-25, TRIP7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025899 9325 TRIP4 http://www.ncbi.nlm.nih.gov/gene/?term=9325 "ASC-1, ASC1, HsT17391, SMABF1, ZC2HC5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025900 9325 TRIP4 http://www.ncbi.nlm.nih.gov/gene/?term=9325 "ASC-1, ASC1, HsT17391, ZC2HC5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025901 9326 ZNHIT3 http://www.ncbi.nlm.nih.gov/gene/?term=9326 TRIP3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025902 9328 GTF3C5 http://www.ncbi.nlm.nih.gov/gene/?term=9328 "TFIIIC63, TFIIICepsilon, TFiiiC2-63 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025903 9329 GTF3C4 http://www.ncbi.nlm.nih.gov/gene/?term=9329 "KAT12, TF3C-delta, TFIII90, TFIIIC290, TFIIIC90, TFIIICDELTA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025904 9330 GTF3C3 http://www.ncbi.nlm.nih.gov/gene/?term=9330 "TFIIIC102, TFIIICgamma, TFiiiC2-102 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025905 9330 GTF3C3 http://www.ncbi.nlm.nih.gov/gene/?term=9330 "TFIIIC102, TFIIICgamma, TFiiiC2-102 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025906 93323 HAUS8 http://www.ncbi.nlm.nih.gov/gene/?term=93323 "DGT4, HICE1, NY-SAR-48 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025907 9332 CD163 http://www.ncbi.nlm.nih.gov/gene/?term=9332 "M130, MM130 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025908 93343 MVB12A http://www.ncbi.nlm.nih.gov/gene/?term=93343 "CFBP, FAM125A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025909 93343 MVB12A http://www.ncbi.nlm.nih.gov/gene/?term=93343 "CFBP, FAM125A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025910 93343 MVB12A http://www.ncbi.nlm.nih.gov/gene/?term=93343 "CFBP, FAM125A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025911 9337 CNOT8 http://www.ncbi.nlm.nih.gov/gene/?term=9337 "CAF1, CALIF, Caf1b, POP2, hCAF1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025912 9338 TCEAL1 http://www.ncbi.nlm.nih.gov/gene/?term=9338 "SIIR, WEX9, p21, pp21 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025913 933 CD22 http://www.ncbi.nlm.nih.gov/gene/?term=933 "SIGLEC-2, SIGLEC2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025914 93408 MYL10 http://www.ncbi.nlm.nih.gov/gene/?term=93408 "MYLC2PL, PLRLC " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025915 93408 MYL10 http://www.ncbi.nlm.nih.gov/gene/?term=93408 "MYLC2PL, PLRLC " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025916 9341 VAMP3 http://www.ncbi.nlm.nih.gov/gene/?term=9341 CEB mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025917 9341 VAMP3 http://www.ncbi.nlm.nih.gov/gene/?term=9341 CEB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025918 9342 SNAP29 http://www.ncbi.nlm.nih.gov/gene/?term=9342 "CEDNIK, SNAP-29 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025919 9342 SNAP29 http://www.ncbi.nlm.nih.gov/gene/?term=9342 "CEDNIK, SNAP-29 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025920 9342 SNAP29 http://www.ncbi.nlm.nih.gov/gene/?term=9342 "CEDNIK, SNAP-29 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025921 9342 SNAP29 http://www.ncbi.nlm.nih.gov/gene/?term=9342 "CEDNIK, SNAP-29 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025922 9342 SNAP29 http://www.ncbi.nlm.nih.gov/gene/?term=9342 "CEDNIK, SNAP-29 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025923 93436 ARMC6 http://www.ncbi.nlm.nih.gov/gene/?term=93436 R30923_1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025924 9343 EFTUD2 http://www.ncbi.nlm.nih.gov/gene/?term=9343 "MFDGA, MFDM, SNRNP116, Snrp116, Snu114, U5-116KD " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025925 9343 EFTUD2 http://www.ncbi.nlm.nih.gov/gene/?term=9343 "MFDGA, MFDM, SNRNP116, Snrp116, Snu114, U5-116KD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025926 9344 TAOK2 http://www.ncbi.nlm.nih.gov/gene/?term=9344 "MAP3K17, PSK, PSK1, PSK1-BETA, TAO1, TAO2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025927 93487 MAPK1IP1L http://www.ncbi.nlm.nih.gov/gene/?term=93487 "C14orf32, MISS, c14_5346 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025928 93487 MAPK1IP1L http://www.ncbi.nlm.nih.gov/gene/?term=93487 "C14orf32, MISS, c14_5346 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025929 93487 MAPK1IP1L http://www.ncbi.nlm.nih.gov/gene/?term=93487 "C14orf32, MISS, c14_5346 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025930 93487 MAPK1IP1L http://www.ncbi.nlm.nih.gov/gene/?term=93487 "C14orf32, MISS, c14_5346 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025931 9349 RPL23 http://www.ncbi.nlm.nih.gov/gene/?term=9349 "L23, rpL17 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025932 9349 RPL23 http://www.ncbi.nlm.nih.gov/gene/?term=9349 "L23, rpL17 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025933 9351 SLC9A3R2 http://www.ncbi.nlm.nih.gov/gene/?term=9351 "E3KARP, NHE3RF2, NHERF-2, NHERF2, OCTS2, SIP-1, SIP1, TKA-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025934 9351 SLC9A3R2 http://www.ncbi.nlm.nih.gov/gene/?term=9351 "E3KARP, NHE3RF2, NHERF-2, NHERF2, OCTS2, SIP-1, SIP1, TKA-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025935 9352 TXNL1 http://www.ncbi.nlm.nih.gov/gene/?term=9352 "HEL-S-114, TRP32, TXL-1, TXNL, Txl " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025936 9352 TXNL1 http://www.ncbi.nlm.nih.gov/gene/?term=9352 "HEL-S-114, TRP32, TXL-1, TXNL, Txl " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025937 9352 TXNL1 http://www.ncbi.nlm.nih.gov/gene/?term=9352 "HEL-S-114, TRP32, TXL-1, TXNL, Txl " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025938 9353 SLIT2 http://www.ncbi.nlm.nih.gov/gene/?term=9353 "SLIL3, Slit-2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025939 9353 SLIT2 http://www.ncbi.nlm.nih.gov/gene/?term=9353 "SLIL3, Slit-2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025940 9354 UBE4A http://www.ncbi.nlm.nih.gov/gene/?term=9354 "E4, UBOX2, UFD2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025941 9355 LHX2 http://www.ncbi.nlm.nih.gov/gene/?term=9355 "LH2, hLhx2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025942 9358 ITGBL1 http://www.ncbi.nlm.nih.gov/gene/?term=9358 "OSCP, TIED " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025943 93594 TBC1D31 http://www.ncbi.nlm.nih.gov/gene/?term=93594 "Gm85, WDR67 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025944 9360 PPIG http://www.ncbi.nlm.nih.gov/gene/?term=9360 "CARS-Cyp, CYP, SCAF10, SRCyp " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025945 93611 FBXO44 http://www.ncbi.nlm.nih.gov/gene/?term=93611 "FBG3, FBX30, FBX6A, Fbx44, Fbxo6a " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025946 93611 FBXO44 http://www.ncbi.nlm.nih.gov/gene/?term=93611 "FBG3, FBX30, FBX6A, Fbx44, Fbxo6a " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025947 9361 LONP1 http://www.ncbi.nlm.nih.gov/gene/?term=9361 "CODASS, LON, LONP, LonHS, PIM1, PRSS15, hLON " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025948 9361 LONP1 http://www.ncbi.nlm.nih.gov/gene/?term=9361 "CODASS, LON, LONP, LonHS, PIM1, PRSS15, hLON " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025949 9361 LONP1 http://www.ncbi.nlm.nih.gov/gene/?term=9361 "CODASS, LON, LONP, LonHS, PIM1, PRSS15, hLON " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025950 93621 MRFAP1 http://www.ncbi.nlm.nih.gov/gene/?term=93621 "PAM14, PGR1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025951 93621 MRFAP1 http://www.ncbi.nlm.nih.gov/gene/?term=93621 "PAM14, PGR1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025952 93621 MRFAP1 http://www.ncbi.nlm.nih.gov/gene/?term=93621 "PAM14, PGR1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025953 93622 LOC93622 http://www.ncbi.nlm.nih.gov/gene/?term=93622 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025954 93627 TBCK http://www.ncbi.nlm.nih.gov/gene/?term=93627 "HSPC302, TBCKL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025955 9364 RAB28 http://www.ncbi.nlm.nih.gov/gene/?term=9364 CORD18 mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025956 93663 ARHGAP18 http://www.ncbi.nlm.nih.gov/gene/?term=93663 "MacGAP, SENEX, bA307O14.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025957 93664 CADPS2 http://www.ncbi.nlm.nih.gov/gene/?term=93664 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025958 93667 Olfm1 http://www.ncbi.nlm.nih.gov/gene/?term=93667 "D2Sut1e, Noe1 " mRNA Rattus norvegicus 25301173 Dendrite Hippocampus In situ hybridization "Figure 2: In situ hybridization reveals species-specific patterns of localization in neuronal dendrites. Fluorescent Microscopy evaluation of biotin-conjugated oligoprobes on paraformaldehyde fixed 14-day cultured rat and mouse cortical neurons hybridized with nine biotin-conjugated oligoprobes detected with streptadivin-Alexa Fluor 568 (Invitrogen). For each probe images set, the small bottom left corner panels represent MAP2 immuno-staining. Scale bar = 20um. (A), Probes against SFRS16, ARHGDIA and HNRPK transcripts show higher dendritic localization in mouse neurons than in rat neurons (Red box). (B), Probes against ZFP410, COMMD3 and RSP6 transcripts show higher dendritic localization in rat neurons than in mouse neurons (Blue box). (C), Probes against UBA52, OLFM1 and H2AFZ transcripts show high dendritic localization in both rat and mouse neurons (Black box). Data are collected from Figure 2. " RLID00025959 9367 RAB9A http://www.ncbi.nlm.nih.gov/gene/?term=9367 RAB9 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025960 9367 RAB9A http://www.ncbi.nlm.nih.gov/gene/?term=9367 RAB9 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025961 93683 Glce http://www.ncbi.nlm.nih.gov/gene/?term=93683 "1110017N23Rik, AI747411, C130034A12Rik, Hsepi " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00025962 93683 Glce http://www.ncbi.nlm.nih.gov/gene/?term=93683 "1110017N23Rik, AI747411, C130034A12Rik, Hsepi " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00025963 93688 Klhl1 http://www.ncbi.nlm.nih.gov/gene/?term=93688 mKIAA1490 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00025964 9368 SLC9A3R1 http://www.ncbi.nlm.nih.gov/gene/?term=9368 "EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025965 9368 SLC9A3R1 http://www.ncbi.nlm.nih.gov/gene/?term=9368 "EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025966 9368 SLC9A3R1 http://www.ncbi.nlm.nih.gov/gene/?term=9368 "EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00025967 9368 SLC9A3R1 http://www.ncbi.nlm.nih.gov/gene/?term=9368 "EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025968 93691 Klf7 http://www.ncbi.nlm.nih.gov/gene/?term=93691 9830124P08Rik mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00025969 93691 Klf7 http://www.ncbi.nlm.nih.gov/gene/?term=93691 9830124P08Rik mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00025970 93695 Gpnmb http://www.ncbi.nlm.nih.gov/gene/?term=93695 "DC-HIL, Dchil, ipd " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00025971 93702 Pcdhgb5 http://www.ncbi.nlm.nih.gov/gene/?term=93702 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00025972 93703 Pcdhgb6 http://www.ncbi.nlm.nih.gov/gene/?term=93703 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00025973 93707 Pcdhgc4 http://www.ncbi.nlm.nih.gov/gene/?term=93707 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00025974 9371 KIF3B http://www.ncbi.nlm.nih.gov/gene/?term=9371 "FLA8, HH0048, KLP-11 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025975 9372 ZFYVE9 http://www.ncbi.nlm.nih.gov/gene/?term=9372 "MADHIP, NSP, PPP1R173, SARA, SMADIP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025976 93730 Lztfl1 http://www.ncbi.nlm.nih.gov/gene/?term=93730 "5530402H04Rik, 6130400H19Rik, AI414725, AW048545 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00025977 93736 Aff4 http://www.ncbi.nlm.nih.gov/gene/?term=93736 "AF5Q31, Alf4, Laf4l, MCEF " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00025978 9373 PLAA http://www.ncbi.nlm.nih.gov/gene/?term=9373 "DOA1, PLA2P, PLAP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025979 93742 Pard3 http://www.ncbi.nlm.nih.gov/gene/?term=93742 "AA960621, AI256638, Asip, D8Ertd580e, Par-3, Par3, Pard-3a, Phip, Pard3 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00025980 93757 Immp2l http://www.ncbi.nlm.nih.gov/gene/?term=93757 "AI853880, IMP2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00025981 93759 Sirt1 http://www.ncbi.nlm.nih.gov/gene/?term=93759 "AA673258, SIR2L1, Sir2, Sir2a, Sir2alpha " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00025982 93759 Sirt1 http://www.ncbi.nlm.nih.gov/gene/?term=93759 "AA673258, SIR2L1, Sir2, Sir2a, Sir2alpha " mRNA Mus musculus 24480879 Cytoplasm B16F1 cell|melanoblasts Immunostaining|RT-PCR The subcellular fractionation of B16F1 cells showed SIRT1 expression in the cytoplasm (Figure 1c). Figure 1. Cytoplasmic SIRT1 promotes the migration of B16F1 cells. (f) SIRT1 small interfering RNAs (SIRT1-siRNAs) suppressed SIRT1 mRNA expression. RLID00025983 9375 TM9SF2 http://www.ncbi.nlm.nih.gov/gene/?term=9375 P76 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025984 9375 TM9SF2 http://www.ncbi.nlm.nih.gov/gene/?term=9375 P76 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025985 9375 TM9SF2 http://www.ncbi.nlm.nih.gov/gene/?term=9375 P76 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025986 93762 Smarca5 http://www.ncbi.nlm.nih.gov/gene/?term=93762 "4933427E24Rik, D030040M08Rik, D330027N15Rik, MommeD4, Snf2h " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00025987 93762 Smarca5 http://www.ncbi.nlm.nih.gov/gene/?term=93762 "4933427E24Rik, D030040M08Rik, D330027N15Rik, MommeD4, Snf2h " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00025988 9377 COX5A http://www.ncbi.nlm.nih.gov/gene/?term=9377 "COX, COX-VA, VA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025989 9377 COX5A http://www.ncbi.nlm.nih.gov/gene/?term=9377 "COX, COX-VA, VA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025990 93790 Nipa2 http://www.ncbi.nlm.nih.gov/gene/?term=93790 "2600017P10Rik, 3830408P04Rik, AB041581 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00025991 9379 NRXN2 http://www.ncbi.nlm.nih.gov/gene/?term=9379 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025992 9380 GRHPR http://www.ncbi.nlm.nih.gov/gene/?term=9380 "GLXR, GLYD, PH2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025993 9380 GRHPR http://www.ncbi.nlm.nih.gov/gene/?term=9380 "GLXR, GLYD, PH2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00025994 9380 GRHPR http://www.ncbi.nlm.nih.gov/gene/?term=9380 "GLXR, GLYD, PH2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025995 9381 OTOF http://www.ncbi.nlm.nih.gov/gene/?term=9381 "AUNB1, DFNB6, DFNB9, FER1L2, NSRD9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025996 9382 COG1 http://www.ncbi.nlm.nih.gov/gene/?term=9382 "CDG2G, LDLB " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00025997 9382 COG1 http://www.ncbi.nlm.nih.gov/gene/?term=9382 "CDG2G, LDLB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00025998 93871 Brwd1 http://www.ncbi.nlm.nih.gov/gene/?term=93871 "5330419I02Rik, D530019K20Rik, G1-403-16, Wdr9, repro5 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00025999 93887 Pcdhb16 http://www.ncbi.nlm.nih.gov/gene/?term=93887 "Pcdhb8, PcdhbP " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026000 93888 Pcdhb17 http://www.ncbi.nlm.nih.gov/gene/?term=93888 "Pcdhb16, PcdhbQ, mKIAA1621 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026001 9388 LIPG http://www.ncbi.nlm.nih.gov/gene/?term=9388 "EDL, EL, PRO719 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026002 9388 LIPG http://www.ncbi.nlm.nih.gov/gene/?term=9388 "EDL, EL, PRO719 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026003 93893 Pcdhb22 http://www.ncbi.nlm.nih.gov/gene/?term=93893 "Pcdhb15, PcdhbV " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026004 9391 CIAO1 http://www.ncbi.nlm.nih.gov/gene/?term=9391 "CIA1, WDR39 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026005 9391 CIAO1 http://www.ncbi.nlm.nih.gov/gene/?term=9391 "CIA1, WDR39 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026006 9392 TGFBRAP1 http://www.ncbi.nlm.nih.gov/gene/?term=9392 "TRAP-1, TRAP1, VPS3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026007 9392 TGFBRAP1 http://www.ncbi.nlm.nih.gov/gene/?term=9392 "TRAP-1, TRAP1, VPS3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026008 9392 TGFBRAP1 http://www.ncbi.nlm.nih.gov/gene/?term=9392 "TRAP-1, TRAP1, VPS3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026009 9394 HS6ST1 http://www.ncbi.nlm.nih.gov/gene/?term=9394 "HH15, HS6ST " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026010 9394 HS6ST1 http://www.ncbi.nlm.nih.gov/gene/?term=9394 "HH15, HS6ST " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026011 93961 B3galt5 http://www.ncbi.nlm.nih.gov/gene/?term=93961 "1190002B21Rik, AU045265, b3Galt-V " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026012 93973 ACTR8 http://www.ncbi.nlm.nih.gov/gene/?term=93973 "ARP8, INO80N, hArp8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026013 93973 ACTR8 http://www.ncbi.nlm.nih.gov/gene/?term=93973 "ARP8, INO80N, hArp8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026014 93974 ATPIF1 http://www.ncbi.nlm.nih.gov/gene/?term=93974 "ATPI, ATPIP, IP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026015 93974 ATPIF1 http://www.ncbi.nlm.nih.gov/gene/?term=93974 "ATPI, ATPIP, IP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026016 93986 FOXP2 http://www.ncbi.nlm.nih.gov/gene/?term=93986 "CAGH44, SPCH1, TNRC10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026017 93 ACVR2B http://www.ncbi.nlm.nih.gov/gene/?term=93 "ACTRIIB, ActR-IIB, HTX4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026018 93 ACVR2B http://www.ncbi.nlm.nih.gov/gene/?term=93 "ACTRIIB, ActR-IIB, HTX4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026019 94005 PIGS http://www.ncbi.nlm.nih.gov/gene/?term=94005 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026020 94009 SERHL http://www.ncbi.nlm.nih.gov/gene/?term=94009 "BK126B4.1, BK126B4.2, HS126B42, dJ222E13.1 " lncRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026021 94015 TTYH2 http://www.ncbi.nlm.nih.gov/gene/?term=94015 C17orf29 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026022 9401 RECQL4 http://www.ncbi.nlm.nih.gov/gene/?term=9401 RECQ4 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026023 9401 RECQL4 http://www.ncbi.nlm.nih.gov/gene/?term=9401 RECQ4 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026024 94025 MUC16 http://www.ncbi.nlm.nih.gov/gene/?term=94025 CA125 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026025 94025 MUC16 http://www.ncbi.nlm.nih.gov/gene/?term=94025 CA125 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026026 9403 SEP15 http://www.ncbi.nlm.nih.gov/gene/?term=9403 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026027 94043 Tm2d1 http://www.ncbi.nlm.nih.gov/gene/?term=94043 "2310026L18Rik, AA990549, Bbp " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026028 9404 LPXN http://www.ncbi.nlm.nih.gov/gene/?term=9404 LDPL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026029 94056 SYAP1 http://www.ncbi.nlm.nih.gov/gene/?term=94056 PRO3113 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026030 94061 Mrpl1 http://www.ncbi.nlm.nih.gov/gene/?term=94061 "2410002L03Rik, 5830418D04Rik, AI462572, L1mt " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026031 94067 Mrpl43 http://www.ncbi.nlm.nih.gov/gene/?term=94067 "4930442D21Rik, bMRP36a " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026032 9406965 SPRRNA.34 http://www.ncbi.nlm.nih.gov/gene/?term=9406965 SPRRNA.34 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.34 RLID00026033 9406 ZRANB2 http://www.ncbi.nlm.nih.gov/gene/?term=9406 "ZIS, ZIS1, ZIS2, ZNF265 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026034 9406 ZRANB2 http://www.ncbi.nlm.nih.gov/gene/?term=9406 "ZIS, ZIS1, ZIS2, ZNF265 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026035 9407007 SPRRNA.39 http://www.ncbi.nlm.nih.gov/gene/?term=9407007 SPRRNA.39 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.39 RLID00026036 9407146 SPRRNA.40 http://www.ncbi.nlm.nih.gov/gene/?term=9407146 SPRRNA.40 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.40 RLID00026037 9407213 snoR61 http://www.ncbi.nlm.nih.gov/gene/?term=9407213 SPNCRNA.445 snoRNA Saccharomyces cerevisiae 25361970 Nucleolus - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPNCRNA.445 RLID00026038 9407306 SPRRNA.35 http://www.ncbi.nlm.nih.gov/gene/?term=9407306 SPRRNA.35 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.35 RLID00026039 9407315 SPRRNA.37 http://www.ncbi.nlm.nih.gov/gene/?term=9407315 SPRRNA.37 rRNA Saccharomyces cerevisiae 25361970 Ribosome - PomBase Data are collected from PomBase database: http://www.pombase.org/spombe/result/SPRRNA.37 RLID00026040 94081 SFXN1 http://www.ncbi.nlm.nih.gov/gene/?term=94081 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026041 94081 SFXN1 http://www.ncbi.nlm.nih.gov/gene/?term=94081 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026042 94081 SFXN1 http://www.ncbi.nlm.nih.gov/gene/?term=94081 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026043 94081 SFXN1 http://www.ncbi.nlm.nih.gov/gene/?term=94081 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026044 94097 SFXN5 http://www.ncbi.nlm.nih.gov/gene/?term=94097 BBG-TCC mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026045 94101 ORMDL1 http://www.ncbi.nlm.nih.gov/gene/?term=94101 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026046 94101 ORMDL1 http://www.ncbi.nlm.nih.gov/gene/?term=94101 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026047 94103 ORMDL3 http://www.ncbi.nlm.nih.gov/gene/?term=94103 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026048 94103 ORMDL3 http://www.ncbi.nlm.nih.gov/gene/?term=94103 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026049 94104 PAXBP1 http://www.ncbi.nlm.nih.gov/gene/?term=94104 "BM020, C21orf66, FSAP105, GCFC, GCFC1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026050 94104 PAXBP1 http://www.ncbi.nlm.nih.gov/gene/?term=94104 "BM020, C21orf66, FSAP105, GCFC, GCFC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026051 94107 TMEM203 http://www.ncbi.nlm.nih.gov/gene/?term=94107 HBEBP1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026052 94107 TMEM203 http://www.ncbi.nlm.nih.gov/gene/?term=94107 HBEBP1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026053 9410 SNRNP40 http://www.ncbi.nlm.nih.gov/gene/?term=9410 "40K, HPRP8BP, PRP8BP, PRPF8BP, SPF38, WDR57 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026054 9410 SNRNP40 http://www.ncbi.nlm.nih.gov/gene/?term=9410 "40K, HPRP8BP, PRP8BP, PRPF8BP, SPF38, WDR57 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026055 94111 Mepe http://www.ncbi.nlm.nih.gov/gene/?term=94111 Of45 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026056 9411 ARHGAP29 http://www.ncbi.nlm.nih.gov/gene/?term=9411 PARG1 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026057 9411 ARHGAP29 http://www.ncbi.nlm.nih.gov/gene/?term=9411 PARG1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026058 9412 MED21 http://www.ncbi.nlm.nih.gov/gene/?term=9412 "SRB7, SURB7, hSrb7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026059 94134 ARHGAP12 http://www.ncbi.nlm.nih.gov/gene/?term=94134 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026060 9415 FADS2 http://www.ncbi.nlm.nih.gov/gene/?term=9415 "D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026061 9415 FADS2 http://www.ncbi.nlm.nih.gov/gene/?term=9415 "D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026062 9415 FADS2 http://www.ncbi.nlm.nih.gov/gene/?term=9415 "D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026063 94161 SNORD46 http://www.ncbi.nlm.nih.gov/gene/?term=94161 "RNU40, RNU46, U40, U46 " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00026064 94161 SNORD46 http://www.ncbi.nlm.nih.gov/gene/?term=94161 "RNU40, RNU46, U40, U46 " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026065 94162 SNORD38A http://www.ncbi.nlm.nih.gov/gene/?term=94162 "RNU38A, U38A " snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026066 94162 SNORD38A http://www.ncbi.nlm.nih.gov/gene/?term=94162 "RNU38A, U38A " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00026067 94162 SNORD38A http://www.ncbi.nlm.nih.gov/gene/?term=94162 "RNU38A, U38A " snoRNA Homo sapiens 25203660 Nucleus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00026068 94162 SNORD38A http://www.ncbi.nlm.nih.gov/gene/?term=94162 "RNU38A, U38A " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026069 94163 SNORD38B http://www.ncbi.nlm.nih.gov/gene/?term=94163 "RNU38B, U38B " snoRNA Homo sapiens 24255815 Exosome Breast cancer cell Next-generation sequencing "Using these criteria, we obtained lower number of annotated transcripts (6,187 transcripts or 3,437 genes) compared to that when RPKM values were considered (Fig. S5 and Table S1). As a result, some transcripts showed high coverage with CDSs criteria (for example, ATPIF1) in exosomal RNA from MDA-MB-231 cells, even when the number of reads was small (less than 5) (Fig. 6B). Such genes were also taken into consideration in our analysis. Data are collected from Table S1. " RLID00026070 94163 SNORD38B http://www.ncbi.nlm.nih.gov/gene/?term=94163 "RNU38B, U38B " snoRNA Homo sapiens 25203660 Nucleolus HeLa cell Next-generation sequencing "Further analysis of the 68 snoRNA loci represented by more than 10 reads in any given fraction showed that 63 mapped to box C/D and 5 to box H/ACA snoRNA loci, respectively (Table S1) showing that box C/D snoRNA-derived reads were highly frequent. Table S1 contains the reads subcellular distribution of the snoRNAs. " RLID00026071 94163 SNORD38B http://www.ncbi.nlm.nih.gov/gene/?term=94163 "RNU38B, U38B " snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026072 94163 SNORD38B http://www.ncbi.nlm.nih.gov/gene/?term=94163 "RNU38B, U38B " snoRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026073 94167 Prdx6 http://www.ncbi.nlm.nih.gov/gene/?term=94167 mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00026074 9416 DDX23 http://www.ncbi.nlm.nih.gov/gene/?term=9416 "PRPF28, SNRNP100, U5-100K, U5-100KD, prp28 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026075 9416 DDX23 http://www.ncbi.nlm.nih.gov/gene/?term=9416 "PRPF28, SNRNP100, U5-100K, U5-100KD, prp28 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026076 94181 Nans http://www.ncbi.nlm.nih.gov/gene/?term=94181 "4632418E04Rik, BB056474, Sas " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00026077 94186 Strn3 http://www.ncbi.nlm.nih.gov/gene/?term=94186 "Gs2na, SG2NA " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026078 94192 C1galt1 http://www.ncbi.nlm.nih.gov/gene/?term=94192 "2210410E06Rik, AV284120, T-synthase " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026079 9419 CRIPT http://www.ncbi.nlm.nih.gov/gene/?term=9419 "HSPC139, SSMDF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026080 9419 CRIPT http://www.ncbi.nlm.nih.gov/gene/?term=9419 "HSPC139, SSMDF " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026081 9419 CRIPT http://www.ncbi.nlm.nih.gov/gene/?term=9419 "HSPC139, SSMDF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026082 9420 CYP7B1 http://www.ncbi.nlm.nih.gov/gene/?term=9420 "CBAS3, CP7B, SPG5A " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026083 94213 Ddx50 http://www.ncbi.nlm.nih.gov/gene/?term=94213 "4933429B04Rik, 8430408E17Rik, GU2, RH-II " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026084 94221 Gopc http://www.ncbi.nlm.nih.gov/gene/?term=94221 "2210402P09Rik, AI844555, CAL, FIG, GOPC1, PIST " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026085 94229 Slc4a10 http://www.ncbi.nlm.nih.gov/gene/?term=94229 "NCBE, mKIAA4136 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026086 9422 ZNF264 http://www.ncbi.nlm.nih.gov/gene/?term=9422 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026087 9422 ZNF264 http://www.ncbi.nlm.nih.gov/gene/?term=9422 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026088 94239 H2AFV http://www.ncbi.nlm.nih.gov/gene/?term=94239 "H2A.Z-2, H2AV " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026089 94239 H2AFV http://www.ncbi.nlm.nih.gov/gene/?term=94239 "H2A.Z-2, H2AV " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026090 94239 H2AFV http://www.ncbi.nlm.nih.gov/gene/?term=94239 "H2A.Z-2, H2AV " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026091 94239 H2AFV http://www.ncbi.nlm.nih.gov/gene/?term=94239 "H2A.Z-2, H2AV " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026092 9424 KCNK6 http://www.ncbi.nlm.nih.gov/gene/?term=9424 "K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026093 9425 CDYL http://www.ncbi.nlm.nih.gov/gene/?term=9425 CDYL1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026094 9425 CDYL http://www.ncbi.nlm.nih.gov/gene/?term=9425 CDYL1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026095 94274 PPP1R14A http://www.ncbi.nlm.nih.gov/gene/?term=94274 "CPI-17, CPI17, PPP1INL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026096 9427 ECEL1 http://www.ncbi.nlm.nih.gov/gene/?term=9427 "DA5D, DINE, ECEX, XCE " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026097 94284 Ugt1a6a http://www.ncbi.nlm.nih.gov/gene/?term=94284 "UDPGT, UDPGT 1-6, UGT1-06, UGT1.6, Ugt1a6, Ugt1a7 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026098 9429 ABCG2 http://www.ncbi.nlm.nih.gov/gene/?term=9429 "ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR-1, MXR1, UAQTL1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026099 94332 Cadm3 http://www.ncbi.nlm.nih.gov/gene/?term=94332 "BIgR, Igsf4b, Necl-1, Necl1, SynCAM3, Tsll1 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026100 94352 Loxl2 http://www.ncbi.nlm.nih.gov/gene/?term=94352 "1110004B06Rik, 4930526G11Rik, 9430067E15Rik " lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026101 943 TNFRSF8 http://www.ncbi.nlm.nih.gov/gene/?term=943 "CD30, D1S166E, Ki-1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026102 9440 MED17 http://www.ncbi.nlm.nih.gov/gene/?term=9440 "CRSP6, CRSP77, DRIP80, TRAP80 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026103 9440 MED17 http://www.ncbi.nlm.nih.gov/gene/?term=9440 "CRSP6, CRSP77, DRIP80, TRAP80 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026104 9440 MED17 http://www.ncbi.nlm.nih.gov/gene/?term=9440 "CRSP6, CRSP77, DRIP80, TRAP80 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026105 9440 MED17 http://www.ncbi.nlm.nih.gov/gene/?term=9440 "CRSP6, CRSP77, DRIP80, TRAP80 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026106 9442 MED27 http://www.ncbi.nlm.nih.gov/gene/?term=9442 "CRAP34, CRSP34, CRSP8, MED3, TRAP37 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026107 9443 MED7 http://www.ncbi.nlm.nih.gov/gene/?term=9443 "ARC34, CRSP33, CRSP9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026108 9444 QKI http://www.ncbi.nlm.nih.gov/gene/?term=9444 "Hqk, QK, QK1, QK3, hqkI " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026109 9444 QKI http://www.ncbi.nlm.nih.gov/gene/?term=9444 "Hqk, QK, QK1, QK3, hqkI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026110 9445 ITM2B http://www.ncbi.nlm.nih.gov/gene/?term=9445 "ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, RDGCA, imBRI2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026111 9445 ITM2B http://www.ncbi.nlm.nih.gov/gene/?term=9445 "ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, RDGCA, imBRI2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026112 9445 ITM2B http://www.ncbi.nlm.nih.gov/gene/?term=9445 "ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, RDGCA, imBRI2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026113 9446 GSTO1 http://www.ncbi.nlm.nih.gov/gene/?term=9446 "GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026114 9446 GSTO1 http://www.ncbi.nlm.nih.gov/gene/?term=9446 "GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026115 9446 GSTO1 http://www.ncbi.nlm.nih.gov/gene/?term=9446 "GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026116 9448 MAP4K4 http://www.ncbi.nlm.nih.gov/gene/?term=9448 "FLH21957, HEL-S-31, HGK, MEKKK4, NIK " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026117 9448 MAP4K4 http://www.ncbi.nlm.nih.gov/gene/?term=9448 "FLH21957, HEL-S-31, HGK, MEKKK4, NIK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026118 9451 EIF2AK3 http://www.ncbi.nlm.nih.gov/gene/?term=9451 "PEK, PERK, WRS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026119 9451 EIF2AK3 http://www.ncbi.nlm.nih.gov/gene/?term=9451 "PEK, PERK, WRS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026120 9452 ITM2A http://www.ncbi.nlm.nih.gov/gene/?term=9452 "BRICD2A, E25A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026121 9453 GGPS1 http://www.ncbi.nlm.nih.gov/gene/?term=9453 "GGPPS, GGPPS1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026122 9453 GGPS1 http://www.ncbi.nlm.nih.gov/gene/?term=9453 "GGPPS, GGPPS1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026123 9454 HOMER3 http://www.ncbi.nlm.nih.gov/gene/?term=9454 "HOMER-3, VESL3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026124 9459 ARHGEF6 http://www.ncbi.nlm.nih.gov/gene/?term=9459 "COOL2, Cool-2, MRX46, PIXA, alpha-PIX, alphaPIX " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026125 9459 ARHGEF6 http://www.ncbi.nlm.nih.gov/gene/?term=9459 "COOL2, Cool-2, MRX46, PIXA, alpha-PIX, alphaPIX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026126 9463 PICK1 http://www.ncbi.nlm.nih.gov/gene/?term=9463 "PICK, PRKCABP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026127 9467 SH3BP5 http://www.ncbi.nlm.nih.gov/gene/?term=9467 "SAB, SH3BP-5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026128 9468 PCYT1B http://www.ncbi.nlm.nih.gov/gene/?term=9468 "CCTB, CTB " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026129 9468 PCYT1B http://www.ncbi.nlm.nih.gov/gene/?term=9468 "CCTB, CTB " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026130 9469 CHST3 http://www.ncbi.nlm.nih.gov/gene/?term=9469 "C6ST, C6ST1, HSD " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026131 9470 EIF4E2 http://www.ncbi.nlm.nih.gov/gene/?term=9470 "4E-LP, 4EHP, EIF4EL3, IF4e " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026132 9470 EIF4E2 http://www.ncbi.nlm.nih.gov/gene/?term=9470 "4E-LP, 4EHP, EIF4EL3, IF4e " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026133 9470 EIF4E2 http://www.ncbi.nlm.nih.gov/gene/?term=9470 "4E-LP, 4EHP, EIF4EL3, IF4e " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026134 9474 ATG5 http://www.ncbi.nlm.nih.gov/gene/?term=9474 "APG5, APG5-LIKE, APG5L, ASP, hAPG5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026135 9474 ATG5 http://www.ncbi.nlm.nih.gov/gene/?term=9474 "APG5, APG5-LIKE, APG5L, ASP, hAPG5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026136 9475 ROCK2 http://www.ncbi.nlm.nih.gov/gene/?term=9475 ROCK-II mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026137 9475 ROCK2 http://www.ncbi.nlm.nih.gov/gene/?term=9475 ROCK-II mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026138 9475 ROCK2 http://www.ncbi.nlm.nih.gov/gene/?term=9475 ROCK-II mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026139 9477 MED20 http://www.ncbi.nlm.nih.gov/gene/?term=9477 "PRO0213, TRFP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026140 9477 MED20 http://www.ncbi.nlm.nih.gov/gene/?term=9477 "PRO0213, TRFP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026141 9479 MAPK8IP1 http://www.ncbi.nlm.nih.gov/gene/?term=9479 "IB1, JIP-1, JIP1, PRKM8IP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026142 947 CD34 http://www.ncbi.nlm.nih.gov/gene/?term=947 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026143 9482 STX8 http://www.ncbi.nlm.nih.gov/gene/?term=9482 CARB mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026144 9482 STX8 http://www.ncbi.nlm.nih.gov/gene/?term=9482 CARB mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026145 9486 CHST10 http://www.ncbi.nlm.nih.gov/gene/?term=9486 "HNK-1ST, HNK1ST " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026146 9486 CHST10 http://www.ncbi.nlm.nih.gov/gene/?term=9486 "HNK-1ST, HNK1ST " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026147 9488 PIGB http://www.ncbi.nlm.nih.gov/gene/?term=9488 "GPI-MT-III, PIG-B " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026148 948 CD36 http://www.ncbi.nlm.nih.gov/gene/?term=948 "BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026149 948 CD36 http://www.ncbi.nlm.nih.gov/gene/?term=948 "BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026150 948 CD36 http://www.ncbi.nlm.nih.gov/gene/?term=948 "BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026151 9491 PSMF1 http://www.ncbi.nlm.nih.gov/gene/?term=9491 PI31 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026152 9491 PSMF1 http://www.ncbi.nlm.nih.gov/gene/?term=9491 PI31 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026153 9493 KIF23 http://www.ncbi.nlm.nih.gov/gene/?term=9493 "CHO1, KNSL5, MKLP-1, MKLP1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026154 9493 KIF23 http://www.ncbi.nlm.nih.gov/gene/?term=9493 "CHO1, KNSL5, MKLP-1, MKLP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026155 9495 AKAP5 http://www.ncbi.nlm.nih.gov/gene/?term=9495 "AKAP75, AKAP79, H21 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026156 9495 AKAP5 http://www.ncbi.nlm.nih.gov/gene/?term=9495 "AKAP75, AKAP79, H21 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026157 9497 SLC4A7 http://www.ncbi.nlm.nih.gov/gene/?term=9497 "NBC2, NBC3, NBCN1, SBC2, SLC4A6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026158 9499 MYOT http://www.ncbi.nlm.nih.gov/gene/?term=9499 "LGMD1, LGMD1A, MFM3, TTID, TTOD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026159 949 SCARB1 http://www.ncbi.nlm.nih.gov/gene/?term=949 "CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026160 94 ACVRL1 http://www.ncbi.nlm.nih.gov/gene/?term=94 "ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026161 9501 RPH3AL http://www.ncbi.nlm.nih.gov/gene/?term=9501 NOC2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026162 9501 RPH3AL http://www.ncbi.nlm.nih.gov/gene/?term=9501 NOC2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026163 9501 RPH3AL http://www.ncbi.nlm.nih.gov/gene/?term=9501 NOC2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026164 9507 ADAMTS4 http://www.ncbi.nlm.nih.gov/gene/?term=9507 "ADAMTS-2, ADAMTS-4, ADMP-1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026165 9507 ADAMTS4 http://www.ncbi.nlm.nih.gov/gene/?term=9507 "ADAMTS-2, ADAMTS-4, ADMP-1 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026166 9508 ADAMTS3 http://www.ncbi.nlm.nih.gov/gene/?term=9508 ADAMTS-4 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026167 9509 ADAMTS2 http://www.ncbi.nlm.nih.gov/gene/?term=9509 "ADAM-TS2, ADAMTS-2, ADAMTS-3, NPI, PC I-NP, PCI-NP, PCINP, PCPNI, PNPI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026168 950 SCARB2 http://www.ncbi.nlm.nih.gov/gene/?term=950 "AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026169 950 SCARB2 http://www.ncbi.nlm.nih.gov/gene/?term=950 "AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026170 950 SCARB2 http://www.ncbi.nlm.nih.gov/gene/?term=950 "AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026171 950 SCARB2 http://www.ncbi.nlm.nih.gov/gene/?term=950 "AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026172 950 SCARB2 http://www.ncbi.nlm.nih.gov/gene/?term=950 "AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026173 9510 ADAMTS1 http://www.ncbi.nlm.nih.gov/gene/?term=9510 "C3-C5, METH1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026174 9512 PMPCB http://www.ncbi.nlm.nih.gov/gene/?term=9512 "Beta-MPP, MPP11, MPPB, MPPP52, P-52 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026175 9512 PMPCB http://www.ncbi.nlm.nih.gov/gene/?term=9512 "Beta-MPP, MPP11, MPPB, MPPP52, P-52 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026176 9513 FXR2 http://www.ncbi.nlm.nih.gov/gene/?term=9513 "FMR1L2P, FXR2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026177 9513 FXR2 http://www.ncbi.nlm.nih.gov/gene/?term=9513 "FMR1L2, FXR2P " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026178 9514 GAL3ST1 http://www.ncbi.nlm.nih.gov/gene/?term=9514 CST mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026179 9516 LITAF http://www.ncbi.nlm.nih.gov/gene/?term=9516 "PIG7, SIMPLE, TP53I7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026180 9516 LITAF http://www.ncbi.nlm.nih.gov/gene/?term=9516 "PIG7, SIMPLE, TP53I7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026181 9517 SPTLC2 http://www.ncbi.nlm.nih.gov/gene/?term=9517 "HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026182 9518 GDF15 http://www.ncbi.nlm.nih.gov/gene/?term=9518 "GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026183 9518 GDF15 http://www.ncbi.nlm.nih.gov/gene/?term=9518 "GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026184 9519 TBPL1 http://www.ncbi.nlm.nih.gov/gene/?term=9519 "MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026185 9519 TBPL1 http://www.ncbi.nlm.nih.gov/gene/?term=9519 "MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026186 9519 TBPL1 http://www.ncbi.nlm.nih.gov/gene/?term=9519 "MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026187 951 CD37 http://www.ncbi.nlm.nih.gov/gene/?term=951 "GP52-40, TSPAN26 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026188 9520 NPEPPS http://www.ncbi.nlm.nih.gov/gene/?term=9520 "AAP-S, MP100, PSA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026189 9520 NPEPPS http://www.ncbi.nlm.nih.gov/gene/?term=9520 "AAP-S, MP100, PSA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026190 9520 NPEPPS http://www.ncbi.nlm.nih.gov/gene/?term=9520 "AAP-S, MP100, PSA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026191 9521 EEF1E1 http://www.ncbi.nlm.nih.gov/gene/?term=9521 "AIMP3, P18 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026192 9521 EEF1E1 http://www.ncbi.nlm.nih.gov/gene/?term=9521 "AIMP3, P18 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026193 9521 EEF1E1 http://www.ncbi.nlm.nih.gov/gene/?term=9521 "AIMP3, P18 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026194 9522 SCAMP1 http://www.ncbi.nlm.nih.gov/gene/?term=9522 "SCAMP, SCAMP37 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026195 9522 SCAMP1 http://www.ncbi.nlm.nih.gov/gene/?term=9522 "SCAMP, SCAMP37 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026196 9522 SCAMP1 http://www.ncbi.nlm.nih.gov/gene/?term=9522 "SCAMP, SCAMP37 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026197 9524 TECR http://www.ncbi.nlm.nih.gov/gene/?term=9524 "GPSN2, MRT14, SC2, TER " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026198 9525 VPS4B http://www.ncbi.nlm.nih.gov/gene/?term=9525 "MIG1, SKD1, SKD1B, VPS4-2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026199 9526 MPDU1 http://www.ncbi.nlm.nih.gov/gene/?term=9526 "CDGIF, HBEBP2BPA, Lec35, My008, PP3958, PQLC5, SL15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026200 9526 MPDU1 http://www.ncbi.nlm.nih.gov/gene/?term=9526 "CDGIF, HBEBP2BPA, Lec35, My008, PP3958, PQLC5, SL15 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026201 9526 MPDU1 http://www.ncbi.nlm.nih.gov/gene/?term=9526 "CDGIF, HBEBP2BPA, Lec35, My008, PP3958, PQLC5, SL15 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026202 9527 GOSR1 http://www.ncbi.nlm.nih.gov/gene/?term=9527 "GOLIM2, GOS-28, GOS28, GOS28/P28, GS28, P28 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026203 9527 GOSR1 http://www.ncbi.nlm.nih.gov/gene/?term=9527 "GOLIM2, GOS-28, GOS28, GOS28/P28, GS28, P28 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026204 9527 GOSR1 http://www.ncbi.nlm.nih.gov/gene/?term=9527 "GOLIM2, GOS-28, GOS28, GOS28/P28, GS28, P28 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026205 9527 GOSR1 http://www.ncbi.nlm.nih.gov/gene/?term=9527 "GOLIM2, GOS-28, GOS28, GOS28/P28, GS28, P28 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026206 9528 TMEM59 http://www.ncbi.nlm.nih.gov/gene/?term=9528 "C1orf8, DCF1, HSPC001, PRO195, UNQ169 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026207 9529 BAG5 http://www.ncbi.nlm.nih.gov/gene/?term=9529 BAG-5 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026208 9530 BAG4 http://www.ncbi.nlm.nih.gov/gene/?term=9530 "BAG-4, SODD " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026209 9530 BAG4 http://www.ncbi.nlm.nih.gov/gene/?term=9530 "BAG-4, SODD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026210 9532 BAG2 http://www.ncbi.nlm.nih.gov/gene/?term=9532 "BAG-2, dJ417I1.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026211 9532 BAG2 http://www.ncbi.nlm.nih.gov/gene/?term=9532 "BAG-2, dJ417I1.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026212 9533 POLR1C http://www.ncbi.nlm.nih.gov/gene/?term=9533 "AC40, HLD11, RPA39, RPA40, RPA5, RPAC1, RPC40, TCS3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026213 9533 POLR1C http://www.ncbi.nlm.nih.gov/gene/?term=9533 "AC40, HLD11, RPA39, RPA40, RPA5, RPAC1, RPC40, TCS3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026214 9537 TP53I11 http://www.ncbi.nlm.nih.gov/gene/?term=9537 PIG11 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026215 9538 EI24 http://www.ncbi.nlm.nih.gov/gene/?term=9538 "EPG4, PIG8, TP53I8 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026216 9538 EI24 http://www.ncbi.nlm.nih.gov/gene/?term=9538 "EPG4, PIG8, TP53I8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026217 953 ENTPD1 http://www.ncbi.nlm.nih.gov/gene/?term=953 "ATPDase, CD39, NTPDase-1, SPG64 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026218 953 ENTPD1 http://www.ncbi.nlm.nih.gov/gene/?term=953 "ATPDase, CD39, NTPDase-1, SPG64 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026219 953 ENTPD1 http://www.ncbi.nlm.nih.gov/gene/?term=953 "ATPDase, CD39, NTPDase-1, SPG64 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026220 9540 TP53I3 http://www.ncbi.nlm.nih.gov/gene/?term=9540 PIG3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026221 9540 TP53I3 http://www.ncbi.nlm.nih.gov/gene/?term=9540 PIG3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026222 9541 CIR1 http://www.ncbi.nlm.nih.gov/gene/?term=9541 CIR mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026223 9542 NRG2 http://www.ncbi.nlm.nih.gov/gene/?term=9542 "DON1, HRG2, NTAK " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026224 9545 RAB3D http://www.ncbi.nlm.nih.gov/gene/?term=9545 "D2-2, GOV, RAB16, RAD3D " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026225 9546 APBA3 http://www.ncbi.nlm.nih.gov/gene/?term=9546 "MGC:15815, X11L2, mint3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026226 9546 APBA3 http://www.ncbi.nlm.nih.gov/gene/?term=9546 "MGC:15815, X11L2, mint3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026227 9550 ATP6V1G1 http://www.ncbi.nlm.nih.gov/gene/?term=9550 "ATP6G, ATP6G1, ATP6GL, ATP6J, Vma10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026228 9550 ATP6V1G1 http://www.ncbi.nlm.nih.gov/gene/?term=9550 "ATP6G, ATP6G1, ATP6GL, ATP6J, Vma10 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026229 9551 ATP5J2 http://www.ncbi.nlm.nih.gov/gene/?term=9551 ATP5JL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026230 9551 ATP5J2 http://www.ncbi.nlm.nih.gov/gene/?term=9551 ATP5JL mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026231 9552 SPAG7 http://www.ncbi.nlm.nih.gov/gene/?term=9552 "ACRP, FSA-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026232 9553 MRPL33 http://www.ncbi.nlm.nih.gov/gene/?term=9553 "C2orf1, L33mt, MRP-L33, RPL33L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026233 9553 MRPL33 http://www.ncbi.nlm.nih.gov/gene/?term=9553 "C2orf1, L33mt, MRP-L33, RPL33L " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026234 9554 SEC22B http://www.ncbi.nlm.nih.gov/gene/?term=9554 "ERS-24, SEC22L1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026235 9555 H2AFY http://www.ncbi.nlm.nih.gov/gene/?term=9555 "H2A.y, H2A/y, H2AF12M, MACROH2A1.1, mH2A1, macroH2A1.2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026236 9555 H2AFY http://www.ncbi.nlm.nih.gov/gene/?term=9555 "H2A.y, H2A/y, H2AF12M, MACROH2A1.1, mH2A1, macroH2A1.2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026237 9556 C14orf2 http://www.ncbi.nlm.nih.gov/gene/?term=9556 "MP68, PLPM " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026238 9556 C14orf2 http://www.ncbi.nlm.nih.gov/gene/?term=9556 "MP68, PLPM " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026239 9557 CHD1L http://www.ncbi.nlm.nih.gov/gene/?term=9557 "ALC1, CHDL " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026240 9559 VPS26A http://www.ncbi.nlm.nih.gov/gene/?term=9559 "HB58, Hbeta58, PEP8A, VPS26 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026241 9559 VPS26A http://www.ncbi.nlm.nih.gov/gene/?term=9559 "HB58, Hbeta58, PEP8A, VPS26 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026242 9559 VPS26A http://www.ncbi.nlm.nih.gov/gene/?term=9559 "HB58, Hbeta58, PEP8A, VPS26 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026243 955 ENTPD6 http://www.ncbi.nlm.nih.gov/gene/?term=955 "CD39L2, IL-6SAG, IL6ST2, NTPDase-6, dJ738P15.3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026244 9562 MINPP1 http://www.ncbi.nlm.nih.gov/gene/?term=9562 "HIPER1, MINPP2, MIPP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026245 9562 MINPP1 http://www.ncbi.nlm.nih.gov/gene/?term=9562 "HIPER1, MINPP2, MIPP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026246 9563 H6PD http://www.ncbi.nlm.nih.gov/gene/?term=9563 "CORTRD1, G6PDH, GDH " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026247 9563 H6PD http://www.ncbi.nlm.nih.gov/gene/?term=9563 "CORTRD1, G6PDH, GDH " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026248 9563 H6PD http://www.ncbi.nlm.nih.gov/gene/?term=9563 "CORTRD1, G6PDH, GDH " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026249 9563 H6PD http://www.ncbi.nlm.nih.gov/gene/?term=9563 "CORTRD1, G6PDH, GDH " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026250 9564 BCAR1 http://www.ncbi.nlm.nih.gov/gene/?term=9564 "CAS, CAS1, CASS1, CRKAS, P130Cas " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026251 9567 GTPBP1 http://www.ncbi.nlm.nih.gov/gene/?term=9567 "GP-1, GP1, HSPC018 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026252 9567 GTPBP1 http://www.ncbi.nlm.nih.gov/gene/?term=9567 "GP-1, GP1, HSPC018 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026253 9567 GTPBP1 http://www.ncbi.nlm.nih.gov/gene/?term=9567 "GP-1, GP1, HSPC018 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026254 9567 GTPBP1 http://www.ncbi.nlm.nih.gov/gene/?term=9567 "GP-1, GP1, HSPC018 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026255 95681 CEP41 http://www.ncbi.nlm.nih.gov/gene/?term=95681 "JBTS15, TSGA14 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026256 9570 GOSR2 http://www.ncbi.nlm.nih.gov/gene/?term=9570 "Bos1, EPM6, GS27 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026257 9570 GOSR2 http://www.ncbi.nlm.nih.gov/gene/?term=9570 "Bos1, EPM6, GS27 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026258 9572 NR1D1 http://www.ncbi.nlm.nih.gov/gene/?term=9572 "EAR1, THRA1, THRAL, ear-1, hRev " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026259 9572 NR1D1 http://www.ncbi.nlm.nih.gov/gene/?term=9572 "EAR1, THRA1, THRAL, ear-1, hRev " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026260 9572 NR1D1 http://www.ncbi.nlm.nih.gov/gene/?term=9572 "EAR1, THRA1, THRAL, ear-1, hRev " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026261 9575 CLOCK http://www.ncbi.nlm.nih.gov/gene/?term=9575 "KAT13D, bHLHe8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026262 9575 CLOCK http://www.ncbi.nlm.nih.gov/gene/?term=9575 "KAT13D, bHLHe8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026263 9577 BRE http://www.ncbi.nlm.nih.gov/gene/?term=9577 "BRCC4, BRCC45 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026264 9577 BRE http://www.ncbi.nlm.nih.gov/gene/?term=9577 "BRCC4, BRCC45 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026265 9578 CDC42BPB http://www.ncbi.nlm.nih.gov/gene/?term=9578 MRCKB mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026266 9578 CDC42BPB http://www.ncbi.nlm.nih.gov/gene/?term=9578 MRCKB mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026267 9578 CDC42BPB http://www.ncbi.nlm.nih.gov/gene/?term=9578 MRCKB mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026268 957 ENTPD5 http://www.ncbi.nlm.nih.gov/gene/?term=957 "CD39L4, NTPDase-5, PCPH " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026269 9581 PREPL http://www.ncbi.nlm.nih.gov/gene/?term=9581 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026270 9581 PREPL http://www.ncbi.nlm.nih.gov/gene/?term=9581 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026271 9581 PREPL http://www.ncbi.nlm.nih.gov/gene/?term=9581 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026272 9583 ENTPD4 http://www.ncbi.nlm.nih.gov/gene/?term=9583 "LALP70, LAP70, LYSAL1, NTPDase-4, UDPase " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026273 9583 ENTPD4 http://www.ncbi.nlm.nih.gov/gene/?term=9583 "LALP70, LAP70, LYSAL1, NTPDase-4, UDPase " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026274 9583 ENTPD4 http://www.ncbi.nlm.nih.gov/gene/?term=9583 "LALP70, LAP70, LYSAL1, NTPDase-4, UDPase " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026275 9583 ENTPD4 http://www.ncbi.nlm.nih.gov/gene/?term=9583 "LALP70, LAP70, LYSAL1, NTPDase-4, UDPase " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026276 9583 ENTPD4 http://www.ncbi.nlm.nih.gov/gene/?term=9583 "LALP70, LAP70, LYSAL1, NTPDase-4, UDPase " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026277 9584 RBM39 http://www.ncbi.nlm.nih.gov/gene/?term=9584 "CAPER, CAPERalpha, FSAP59, HCC1, RNPC2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026278 9584 RBM39 http://www.ncbi.nlm.nih.gov/gene/?term=9584 "CAPER, CAPERalpha, FSAP59, HCC1, RNPC2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026279 9584 RBM39 http://www.ncbi.nlm.nih.gov/gene/?term=9584 "CAPER, CAPERalpha, FSAP59, HCC1, RNPC2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026280 9584 RBM39 http://www.ncbi.nlm.nih.gov/gene/?term=9584 "CAPER, CAPERalpha, FSAP59, HCC1, RNPC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026281 9585 KIF20B http://www.ncbi.nlm.nih.gov/gene/?term=9585 "CT90, KRMP1, MPHOSPH1, MPP-1, MPP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026282 9585 KIF20B http://www.ncbi.nlm.nih.gov/gene/?term=9585 "CT90, KRMP1, MPHOSPH1, MPP-1, MPP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026283 9586 CREB5 http://www.ncbi.nlm.nih.gov/gene/?term=9586 "CRE-BPA, CREB-5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026284 9587 MAD2L1BP http://www.ncbi.nlm.nih.gov/gene/?term=9587 CMT2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026285 9587 MAD2L1BP http://www.ncbi.nlm.nih.gov/gene/?term=9587 CMT2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026286 9587 MAD2L1BP http://www.ncbi.nlm.nih.gov/gene/?term=9587 CMT2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026287 9588 PRDX6 http://www.ncbi.nlm.nih.gov/gene/?term=9588 "1-Cys, AOP2, HEL-S-128m, NSGPx, PRX, aiPLA2, p29 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026288 9588 PRDX6 http://www.ncbi.nlm.nih.gov/gene/?term=9588 "1-Cys, AOP2, HEL-S-128m, NSGPx, PRX, aiPLA2, p29 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026289 9588 PRDX6 http://www.ncbi.nlm.nih.gov/gene/?term=9588 "1-Cys, AOP2, HEL-S-128m, NSGPx, PRX, aiPLA2, p29 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026290 958 CD40 http://www.ncbi.nlm.nih.gov/gene/?term=958 "Bp50, CDW40, TNFRSF5, p50 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026291 9590 AKAP12 http://www.ncbi.nlm.nih.gov/gene/?term=9590 "AKAP250, SSeCKS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026292 9590 AKAP12 http://www.ncbi.nlm.nih.gov/gene/?term=9590 "AKAP250, SSeCKS " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026293 9592 IER2 http://www.ncbi.nlm.nih.gov/gene/?term=9592 ETR101 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026294 9592 IER2 http://www.ncbi.nlm.nih.gov/gene/?term=9592 ETR101 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026295 9592 IER2 http://www.ncbi.nlm.nih.gov/gene/?term=9592 ETR101 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026296 95 ACY1 http://www.ncbi.nlm.nih.gov/gene/?term=95 "ACY-1, ACY1D, HEL-S-5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026297 9600 PITPNM1 http://www.ncbi.nlm.nih.gov/gene/?term=9600 "DRES9, NIR2, PITPNM, RDGB, RDGB1, RDGBA, RDGBA1, Rd9 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026298 9600 PITPNM1 http://www.ncbi.nlm.nih.gov/gene/?term=9600 "DRES9, NIR2, PITPNM, RDGB, RDGB1, RDGBA, RDGBA1, Rd9 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026299 9601 PDIA4 http://www.ncbi.nlm.nih.gov/gene/?term=9601 "ERP70, ERP72, ERp-72 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026300 9601 PDIA4 http://www.ncbi.nlm.nih.gov/gene/?term=9601 "ERP70, ERP72, ERp-72 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026301 9603 NFE2L3 http://www.ncbi.nlm.nih.gov/gene/?term=9603 NRF3 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026302 9603 NFE2L3 http://www.ncbi.nlm.nih.gov/gene/?term=9603 NRF3 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026303 9604 RNF14 http://www.ncbi.nlm.nih.gov/gene/?term=9604 "ARA54, HFB30, HRIHFB2038, TRIAD2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026304 9604 RNF14 http://www.ncbi.nlm.nih.gov/gene/?term=9604 "ARA54, HFB30, HRIHFB2038, TRIAD2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026305 9604 RNF14 http://www.ncbi.nlm.nih.gov/gene/?term=9604 "ARA54, HFB30, HRIHFB2038, TRIAD2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026306 9605 VPS9D1 http://www.ncbi.nlm.nih.gov/gene/?term=9605 "ATP-BL, C16orf7 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026307 9609 RAB36 http://www.ncbi.nlm.nih.gov/gene/?term=9609 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026308 9609 RAB36 http://www.ncbi.nlm.nih.gov/gene/?term=9609 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026309 960 CD44 http://www.ncbi.nlm.nih.gov/gene/?term=960 "CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026310 960 CD44 http://www.ncbi.nlm.nih.gov/gene/?term=960 "CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026311 9610 RIN1 http://www.ncbi.nlm.nih.gov/gene/?term=9610 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026312 9611 NCOR1 http://www.ncbi.nlm.nih.gov/gene/?term=9611 "N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026313 9611 NCOR1 http://www.ncbi.nlm.nih.gov/gene/?term=9611 "N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026314 9611 NCOR1 http://www.ncbi.nlm.nih.gov/gene/?term=9611 "N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026315 9611 NCOR1 http://www.ncbi.nlm.nih.gov/gene/?term=9611 "N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026316 9612 NCOR2 http://www.ncbi.nlm.nih.gov/gene/?term=9612 "CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026317 9615 GDA http://www.ncbi.nlm.nih.gov/gene/?term=9615 "CYPIN, GUANASE, NEDASIN " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026318 9616 RNF7 http://www.ncbi.nlm.nih.gov/gene/?term=9616 "CKBBP1, ROC2, SAG " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026319 9616 RNF7 http://www.ncbi.nlm.nih.gov/gene/?term=9616 "CKBBP1, ROC2, SAG " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026320 9616 RNF7 http://www.ncbi.nlm.nih.gov/gene/?term=9616 "CKBBP1, ROC2, SAG " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026321 9618 TRAF4 http://www.ncbi.nlm.nih.gov/gene/?term=9618 "CART1, MLN62, RNF83 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026322 9618 TRAF4 http://www.ncbi.nlm.nih.gov/gene/?term=9618 "CART1, MLN62, RNF83 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026323 9618 TRAF4 http://www.ncbi.nlm.nih.gov/gene/?term=9618 "CART1, MLN62, RNF83 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026324 9619 ABCG1 http://www.ncbi.nlm.nih.gov/gene/?term=9619 "ABC8, WHITE1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026325 961 CD47 http://www.ncbi.nlm.nih.gov/gene/?term=961 "IAP, MER6, OA3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026326 961 CD47 http://www.ncbi.nlm.nih.gov/gene/?term=961 "IAP, MER6, OA3 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026327 961 CD47 http://www.ncbi.nlm.nih.gov/gene/?term=961 "IAP, MER6, OA3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026328 9628 RGS6 http://www.ncbi.nlm.nih.gov/gene/?term=9628 GAP mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026329 962 CD48 http://www.ncbi.nlm.nih.gov/gene/?term=962 "BCM1, BLAST, BLAST1, MEM-102, SLAMF2, hCD48, mCD48 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026330 9631 NUP155 http://www.ncbi.nlm.nih.gov/gene/?term=9631 "ATFB15, N155 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026331 9631 NUP155 http://www.ncbi.nlm.nih.gov/gene/?term=9631 "ATFB15, N155 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026332 9632 SEC24C http://www.ncbi.nlm.nih.gov/gene/?term=9632 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026333 9632 SEC24C http://www.ncbi.nlm.nih.gov/gene/?term=9632 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026334 9632 SEC24C http://www.ncbi.nlm.nih.gov/gene/?term=9632 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026335 9632 SEC24C http://www.ncbi.nlm.nih.gov/gene/?term=9632 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026336 9633 MTL5 http://www.ncbi.nlm.nih.gov/gene/?term=9633 "CXCDC2, MTLT, TESMIN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026337 9633 MTL5 http://www.ncbi.nlm.nih.gov/gene/?term=9633 "CXCDC2, MTLT, TESMIN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026338 9636 ISG15 http://www.ncbi.nlm.nih.gov/gene/?term=9636 "G1P2, IFI15, IMD38, IP17, UCRP, hUCRP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026339 9636 ISG15 http://www.ncbi.nlm.nih.gov/gene/?term=9636 "G1P2, IFI15, IMD38, IP17, UCRP, hUCRP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026340 9637 FEZ2 http://www.ncbi.nlm.nih.gov/gene/?term=9637 HUM3CL mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026341 9638 FEZ1 http://www.ncbi.nlm.nih.gov/gene/?term=9638 UNC-76 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026342 9638 FEZ1 http://www.ncbi.nlm.nih.gov/gene/?term=9638 UNC-76 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026343 9638 FEZ1 http://www.ncbi.nlm.nih.gov/gene/?term=9638 UNC-76 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026344 9639 ARHGEF10 http://www.ncbi.nlm.nih.gov/gene/?term=9639 "GEF10, SNCV " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026345 963 CD53 http://www.ncbi.nlm.nih.gov/gene/?term=963 "MOX44, TSPAN25 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026346 9640 ZNF592 http://www.ncbi.nlm.nih.gov/gene/?term=9640 "CAMOS, SCAR5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026347 9641 IKBKE http://www.ncbi.nlm.nih.gov/gene/?term=9641 "IKK-E, IKK-i, IKKE, IKKI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026348 9643 MORF4L2 http://www.ncbi.nlm.nih.gov/gene/?term=9643 "MORFL2, MRGX " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026349 9643 MORF4L2 http://www.ncbi.nlm.nih.gov/gene/?term=9643 "MORFL2, MRGX " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026350 96459 FNIP1 http://www.ncbi.nlm.nih.gov/gene/?term=96459 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026351 96459 FNIP1 http://www.ncbi.nlm.nih.gov/gene/?term=96459 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026352 96459 FNIP1 http://www.ncbi.nlm.nih.gov/gene/?term=96459 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026353 9645 MICAL2 http://www.ncbi.nlm.nih.gov/gene/?term=9645 "MICAL-2PV1, MICAL2PV2, MICAL2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026354 9645 MICAL2 http://www.ncbi.nlm.nih.gov/gene/?term=9645 "MICAL-2, MICAL2PV1, MICAL2PV2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026355 9646 CTR9 http://www.ncbi.nlm.nih.gov/gene/?term=9646 "SH2BP1, TSBP, p150, p150TSP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026356 9647 PPM1F http://www.ncbi.nlm.nih.gov/gene/?term=9647 "CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026357 9647 PPM1F http://www.ncbi.nlm.nih.gov/gene/?term=9647 "CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026358 9650 MTFR1 http://www.ncbi.nlm.nih.gov/gene/?term=9650 "CHPPR, FAM54A2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026359 9652 TTC37 http://www.ncbi.nlm.nih.gov/gene/?term=9652 "KIAA0372, Ski3, THES " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026360 9652 TTC37 http://www.ncbi.nlm.nih.gov/gene/?term=9652 "KIAA0372, Ski3, THES " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026361 9653 HS2ST1 http://www.ncbi.nlm.nih.gov/gene/?term=9653 dJ604K5.2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026362 9654 TTLL4 http://www.ncbi.nlm.nih.gov/gene/?term=9654 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026363 9655 SOCS5 http://www.ncbi.nlm.nih.gov/gene/?term=9655 "CIS6, CISH6, Cish5, SOCS-5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026364 9656 MDC1 http://www.ncbi.nlm.nih.gov/gene/?term=9656 NFBD1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026365 9657 IQCB1 http://www.ncbi.nlm.nih.gov/gene/?term=9657 "NPHP5, PIQ, SLSN5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026366 9657 IQCB1 http://www.ncbi.nlm.nih.gov/gene/?term=9657 "NPHP5, PIQ, SLSN5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026367 9659 PDE4DIP http://www.ncbi.nlm.nih.gov/gene/?term=9659 "CMYA2, MMGL " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026368 9659 PDE4DIP http://www.ncbi.nlm.nih.gov/gene/?term=9659 "CMYA2, MMGL " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026369 965 CD58 http://www.ncbi.nlm.nih.gov/gene/?term=965 "LFA-3, LFA3, ag3 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026370 96626 LIMS3 http://www.ncbi.nlm.nih.gov/gene/?term=96626 PINCH-3 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026371 9665 KIAA0430 http://www.ncbi.nlm.nih.gov/gene/?term=9665 "LKAP, MARF1, PPP1R34 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026372 9666 DZIP3 http://www.ncbi.nlm.nih.gov/gene/?term=9666 "PPP1R66, UURF2, hRUL138 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026373 9666 DZIP3 http://www.ncbi.nlm.nih.gov/gene/?term=9666 "PPP1R66, UURF2, hRUL138 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026374 9667 SAFB2 http://www.ncbi.nlm.nih.gov/gene/?term=9667 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026375 9667 SAFB2 http://www.ncbi.nlm.nih.gov/gene/?term=9667 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026376 9669 EIF5B http://www.ncbi.nlm.nih.gov/gene/?term=9669 IF2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026377 9669 EIF5B http://www.ncbi.nlm.nih.gov/gene/?term=9669 IF2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026378 966 CD59 http://www.ncbi.nlm.nih.gov/gene/?term=966 "16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026379 966 CD59 http://www.ncbi.nlm.nih.gov/gene/?term=966 "16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026380 9670 IPO13 http://www.ncbi.nlm.nih.gov/gene/?term=9670 "IMP13, KAP13, LGL2, RANBP13 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026381 9671 WSCD2 http://www.ncbi.nlm.nih.gov/gene/?term=9671 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026382 9672 SDC3 http://www.ncbi.nlm.nih.gov/gene/?term=9672 "SDCN, SYND3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026383 9674 KIAA0040 http://www.ncbi.nlm.nih.gov/gene/?term=9674 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026384 96764 TGS1 http://www.ncbi.nlm.nih.gov/gene/?term=96764 "NCOA6IP, PIMT, PIPMT " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026385 96764 TGS1 http://www.ncbi.nlm.nih.gov/gene/?term=96764 "NCOA6IP, PIMT, PIPMT " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026386 96764 TGS1 http://www.ncbi.nlm.nih.gov/gene/?term=96764 "NCOA6IP, PIMT, PIPMT " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026387 9677 PPIP5K1 http://www.ncbi.nlm.nih.gov/gene/?term=9677 "HISPPD2A, IP6K, IPS1, VIP1, hsVIP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026388 9678 PHF14 http://www.ncbi.nlm.nih.gov/gene/?term=9678 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026389 9679 FAM53B http://www.ncbi.nlm.nih.gov/gene/?term=9679 "KIAA0140, bA12J10.2, smp " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026390 967 CD63 http://www.ncbi.nlm.nih.gov/gene/?term=967 "LAMP-3, ME491, MLA1, OMA81H, TSPAN30 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026391 9682 KDM4A http://www.ncbi.nlm.nih.gov/gene/?term=9682 "JHDM3A, JMJD2, JMJD2A, TDRD14A " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026392 9682 KDM4A http://www.ncbi.nlm.nih.gov/gene/?term=9682 "JHDM3A, JMJD2, JMJD2A, TDRD14A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026393 9683 N4BP1 http://www.ncbi.nlm.nih.gov/gene/?term=9683 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026394 9685 CLINT1 http://www.ncbi.nlm.nih.gov/gene/?term=9685 "CLINT, ENTH, EPN4, EPNR " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026395 9685 CLINT1 http://www.ncbi.nlm.nih.gov/gene/?term=9685 "CLINT, ENTH, EPN4, EPNR " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026396 9685 CLINT1 http://www.ncbi.nlm.nih.gov/gene/?term=9685 "CLINT, ENTH, EPN4, EPNR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026397 9687 GREB1 http://www.ncbi.nlm.nih.gov/gene/?term=9687 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026398 9687 GREB1 http://www.ncbi.nlm.nih.gov/gene/?term=9687 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026399 9688 NUP93 http://www.ncbi.nlm.nih.gov/gene/?term=9688 "NIC96, NPHS12 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026400 9688 NUP93 http://www.ncbi.nlm.nih.gov/gene/?term=9688 NIC96 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026401 96891 C79246 http://www.ncbi.nlm.nih.gov/gene/?term=96891 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026402 9689 BZW1 http://www.ncbi.nlm.nih.gov/gene/?term=9689 "BZAP45, Nbla10236 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026403 9689 BZW1 http://www.ncbi.nlm.nih.gov/gene/?term=9689 "BZAP45, Nbla10236 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026404 9689 BZW1 http://www.ncbi.nlm.nih.gov/gene/?term=9689 "BZAP45, Nbla10236 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026405 968 CD68 http://www.ncbi.nlm.nih.gov/gene/?term=968 "GP110, LAMP4, SCARD1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026406 96907 C81001 http://www.ncbi.nlm.nih.gov/gene/?term=96907 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026407 9690 UBE3C http://www.ncbi.nlm.nih.gov/gene/?term=9690 HECTH2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026408 9690 UBE3C http://www.ncbi.nlm.nih.gov/gene/?term=9690 HECTH2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026409 9692 KIAA0391 http://www.ncbi.nlm.nih.gov/gene/?term=9692 "MRPP3, PRORP " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026410 9693 RAPGEF2 http://www.ncbi.nlm.nih.gov/gene/?term=9693 "CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026411 9694 EMC2 http://www.ncbi.nlm.nih.gov/gene/?term=9694 "KIAA0103, TTC35 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026412 9695 EDEM1 http://www.ncbi.nlm.nih.gov/gene/?term=9695 EDEM mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026413 9695 EDEM1 http://www.ncbi.nlm.nih.gov/gene/?term=9695 EDEM mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026414 9695 EDEM1 http://www.ncbi.nlm.nih.gov/gene/?term=9695 EDEM mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026415 96961 C77609 http://www.ncbi.nlm.nih.gov/gene/?term=96961 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026416 96979 Ptges2 http://www.ncbi.nlm.nih.gov/gene/?term=96979 "0610038H10Rik, C79137, Gbf1, Mpges2, Pges2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026417 9697 TRAM2 http://www.ncbi.nlm.nih.gov/gene/?term=9697 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026418 9697 TRAM2 http://www.ncbi.nlm.nih.gov/gene/?term=9697 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026419 9698 PUM1 http://www.ncbi.nlm.nih.gov/gene/?term=9698 "HSPUM, PUMH, PUMH1, PUML1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026420 9699 RIMS2 http://www.ncbi.nlm.nih.gov/gene/?term=9699 "OBOE, RAB3IP3, RIM2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026421 9700 ESPL1 http://www.ncbi.nlm.nih.gov/gene/?term=9700 "ESP1, SEPA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026422 9700 ESPL1 http://www.ncbi.nlm.nih.gov/gene/?term=9700 "ESP1, SEPA " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026423 9700 ESPL1 http://www.ncbi.nlm.nih.gov/gene/?term=9700 "ESP1, SEPA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026424 9701 PPP6R2 http://www.ncbi.nlm.nih.gov/gene/?term=9701 "KIAA0685, PP6R2, SAP190, SAPS2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026425 9702 CEP57 http://www.ncbi.nlm.nih.gov/gene/?term=9702 "MVA2, PIG8, TSP57 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026426 9702 CEP57 http://www.ncbi.nlm.nih.gov/gene/?term=9702 "MVA2, PIG8, TSP57 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026427 9702 CEP57 http://www.ncbi.nlm.nih.gov/gene/?term=9702 "MVA2, PIG8, TSP57 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026428 97031 Tprn http://www.ncbi.nlm.nih.gov/gene/?term=97031 "C430004E15Rik, C87750 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026429 9703 KIAA0100 http://www.ncbi.nlm.nih.gov/gene/?term=9703 "BCOX, BCOX1, CT101 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026430 9703 KIAA0100 http://www.ncbi.nlm.nih.gov/gene/?term=9703 "BCOX, BCOX1, CT101 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026431 9703 KIAA0100 http://www.ncbi.nlm.nih.gov/gene/?term=9703 "BCOX, BCOX1, CT101 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026432 9704 DHX34 http://www.ncbi.nlm.nih.gov/gene/?term=9704 "DDX34, HRH1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026433 9704 DHX34 http://www.ncbi.nlm.nih.gov/gene/?term=9704 "DDX34, HRH1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026434 97067 C78651 http://www.ncbi.nlm.nih.gov/gene/?term=97067 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026435 9709 HERPUD1 http://www.ncbi.nlm.nih.gov/gene/?term=9709 "HERP, Mif1, SUP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026436 970 CD70 http://www.ncbi.nlm.nih.gov/gene/?term=970 "CD27L, CD27LG, TNFSF7, TNLG8A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026437 9710 KIAA0355 http://www.ncbi.nlm.nih.gov/gene/?term=9710 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026438 97112 Nmd3 http://www.ncbi.nlm.nih.gov/gene/?term=97112 C87860 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026439 9711 RUBCN http://www.ncbi.nlm.nih.gov/gene/?term=9711 "KIAA0226, RUBICON, SCAR15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026440 9712 USP6NL http://www.ncbi.nlm.nih.gov/gene/?term=9712 "RNTRE, TRE2NL, USP6NL-IT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026441 97148 C78692 http://www.ncbi.nlm.nih.gov/gene/?term=97148 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026442 97165 Hmgb2 http://www.ncbi.nlm.nih.gov/gene/?term=97165 "C80539, HMG-2, Hmg2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026443 9716 AQR http://www.ncbi.nlm.nih.gov/gene/?term=9716 "IBP160, fSAP164 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026444 9716 AQR http://www.ncbi.nlm.nih.gov/gene/?term=9716 "IBP160, fSAP164 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026445 9718 ECE2 http://www.ncbi.nlm.nih.gov/gene/?term=9718 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026446 97225 C77815 http://www.ncbi.nlm.nih.gov/gene/?term=97225 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026447 9725 TMEM63A http://www.ncbi.nlm.nih.gov/gene/?term=9725 KIAA0792 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026448 9725 TMEM63A http://www.ncbi.nlm.nih.gov/gene/?term=9725 KIAA0792 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026449 9726 ZNF646 http://www.ncbi.nlm.nih.gov/gene/?term=9726 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026450 9727 RAB11FIP3 http://www.ncbi.nlm.nih.gov/gene/?term=9727 "CART1, Rab11-FIP3 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026451 9727 RAB11FIP3 http://www.ncbi.nlm.nih.gov/gene/?term=9727 "CART1, Rab11-FIP3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026452 9728 SECISBP2L http://www.ncbi.nlm.nih.gov/gene/?term=9728 "SBP2L, SLAN " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026453 9731 CEP104 http://www.ncbi.nlm.nih.gov/gene/?term=9731 "CFAP256, GlyBP, JBTS25, KIAA0562, ROC22 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026454 9731 CEP104 http://www.ncbi.nlm.nih.gov/gene/?term=9731 "CFAP256, GlyBP, JBTS25, KIAA0562, ROC22 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026455 9733 SART3 http://www.ncbi.nlm.nih.gov/gene/?term=9733 "DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb) " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026456 9733 SART3 http://www.ncbi.nlm.nih.gov/gene/?term=9733 "DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb) " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026457 9733 SART3 http://www.ncbi.nlm.nih.gov/gene/?term=9733 "DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb) " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026458 9734 HDAC9 http://www.ncbi.nlm.nih.gov/gene/?term=9734 "HD7, HD9, HD7b, HDAC, HDRP, MITR, HDAC7, HDAC7B, HDAC9B, HDAC9FL " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00026459 9735 KNTC1 http://www.ncbi.nlm.nih.gov/gene/?term=9735 ROD mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026460 9736 USP34 http://www.ncbi.nlm.nih.gov/gene/?term=9736 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026461 9737 GPRASP1 http://www.ncbi.nlm.nih.gov/gene/?term=9737 "GASP, GASP-1, GASP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026462 97389 C80893 http://www.ncbi.nlm.nih.gov/gene/?term=97389 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026463 9738 CCP110 http://www.ncbi.nlm.nih.gov/gene/?term=9738 "CP110, Cep110 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026464 9739 SETD1A http://www.ncbi.nlm.nih.gov/gene/?term=9739 "KMT2F, Set1, Set1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026465 9741 LAPTM4A http://www.ncbi.nlm.nih.gov/gene/?term=9741 "HUMORF13, LAPTM4, MBNT, Mtrp " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026466 9741 LAPTM4A http://www.ncbi.nlm.nih.gov/gene/?term=9741 "HUMORF13, LAPTM4, MBNT, Mtrp " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026467 9743 ARHGAP32 http://www.ncbi.nlm.nih.gov/gene/?term=9743 "GC-GAP, GRIT, PX-RICS, RICS, p200RhoGAP, p250GAP " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026468 97455 C78859 http://www.ncbi.nlm.nih.gov/gene/?term=97455 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026469 9746 CLSTN3 http://www.ncbi.nlm.nih.gov/gene/?term=9746 "CDHR14, CSTN3, alcbeta " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026470 97476 Fam90a1a http://www.ncbi.nlm.nih.gov/gene/?term=97476 C86695 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026471 9747 TCAF1 http://www.ncbi.nlm.nih.gov/gene/?term=9747 FAM115A mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026472 97484 Cog8 http://www.ncbi.nlm.nih.gov/gene/?term=97484 "BB235941, C87832 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026473 97487 Cmtm4 http://www.ncbi.nlm.nih.gov/gene/?term=97487 "Cklfsf4, D19397, ENSMUSG00000051554, Gm9853 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026474 9748 SLK http://www.ncbi.nlm.nih.gov/gene/?term=9748 "LOSK, STK2, bA16H23.1, se20-9 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026475 9748 SLK http://www.ncbi.nlm.nih.gov/gene/?term=9748 "LOSK, STK2, bA16H23.1, se20-9 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026476 9748 SLK http://www.ncbi.nlm.nih.gov/gene/?term=9748 "LOSK, STK2, bA16H23.1, se20-9 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026477 9749 PHACTR2 http://www.ncbi.nlm.nih.gov/gene/?term=9749 C6orf56 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026478 9751 SNPH http://www.ncbi.nlm.nih.gov/gene/?term=9751 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026479 9752 PCDHA9 http://www.ncbi.nlm.nih.gov/gene/?term=9752 PCDH-ALPHA9 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026480 9752 PCDHA9 http://www.ncbi.nlm.nih.gov/gene/?term=9752 PCDH-ALPHA9 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026481 9755 TBKBP1 http://www.ncbi.nlm.nih.gov/gene/?term=9755 "ProSAPiP2, SINTBAD " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026482 97569 C87580 http://www.ncbi.nlm.nih.gov/gene/?term=97569 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026483 9759 HDAC4 http://www.ncbi.nlm.nih.gov/gene/?term=9759 "HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A " mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00026484 975 CD81 http://www.ncbi.nlm.nih.gov/gene/?term=975 "CVID6, S5.7, TAPA1, TSPAN28 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026485 975 CD81 http://www.ncbi.nlm.nih.gov/gene/?term=975 "CVID6, S5.7, TAPA1, TSPAN28 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026486 975 CD81 http://www.ncbi.nlm.nih.gov/gene/?term=975 "CVID6, S5.7, TAPA1, TSPAN28 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026487 9761 MLEC http://www.ncbi.nlm.nih.gov/gene/?term=9761 KIAA0152 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026488 9761 MLEC http://www.ncbi.nlm.nih.gov/gene/?term=9761 KIAA0152 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026489 9762 LZTS3 http://www.ncbi.nlm.nih.gov/gene/?term=9762 PROSAPIP1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026490 9764 KIAA0513 http://www.ncbi.nlm.nih.gov/gene/?term=9764 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026491 9764 KIAA0513 http://www.ncbi.nlm.nih.gov/gene/?term=9764 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026492 9764 KIAA0513 http://www.ncbi.nlm.nih.gov/gene/?term=9764 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026493 9765 ZFYVE16 http://www.ncbi.nlm.nih.gov/gene/?term=9765 PPP1R69 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026494 9765 ZFYVE16 http://www.ncbi.nlm.nih.gov/gene/?term=9765 PPP1R69 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026495 97662 C86090 http://www.ncbi.nlm.nih.gov/gene/?term=97662 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026496 9766 SUSD6 http://www.ncbi.nlm.nih.gov/gene/?term=9766 "DRAGO, KIAA0247 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026497 9768 KIAA0101 http://www.ncbi.nlm.nih.gov/gene/?term=9768 "L5, NS5ATP9, OEATC, OEATC-1, OEATC1, PAF, PAF15, p15(PAF), p15/PAF, p15PAF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026498 976 ADGRE5 http://www.ncbi.nlm.nih.gov/gene/?term=976 "CD97, TM7LN1 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026499 9770 RASSF2 http://www.ncbi.nlm.nih.gov/gene/?term=9770 "CENP-34, RASFADIN " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026500 9770 RASSF2 http://www.ncbi.nlm.nih.gov/gene/?term=9770 "CENP-34, RASFADIN " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026501 97714 C78891 http://www.ncbi.nlm.nih.gov/gene/?term=97714 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026502 97726 C80165 http://www.ncbi.nlm.nih.gov/gene/?term=97726 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026503 9772 TMEM94 http://www.ncbi.nlm.nih.gov/gene/?term=9772 KIAA0195 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026504 9774 BCLAF1 http://www.ncbi.nlm.nih.gov/gene/?term=9774 "BTF, bK211L9.1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026505 9774 BCLAF1 http://www.ncbi.nlm.nih.gov/gene/?term=9774 "BTF, bK211L9.1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026506 9774 BCLAF1 http://www.ncbi.nlm.nih.gov/gene/?term=9774 "BTF, bK211L9.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026507 9775 EIF4A3 http://www.ncbi.nlm.nih.gov/gene/?term=9775 "DDX48, MUK34, NMP265, NUK34, RCPS, eIF4AIII " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026508 9775 EIF4A3 http://www.ncbi.nlm.nih.gov/gene/?term=9775 "DDX48, MUK34, NMP265, NUK34, RCPS, eIF4AIII " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026509 9775 EIF4A3 http://www.ncbi.nlm.nih.gov/gene/?term=9775 "DDX48, MUK34, NMP265, NUK34, RCPS, eIF4AIII " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026510 9776 ATG13 http://www.ncbi.nlm.nih.gov/gene/?term=9776 "KIAA0652, PARATARG8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026511 9776 ATG13 http://www.ncbi.nlm.nih.gov/gene/?term=9776 "KIAA0652, PARATARG8 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026512 9776 ATG13 http://www.ncbi.nlm.nih.gov/gene/?term=9776 "KIAA0652, PARATARG8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026513 9777 TM9SF4 http://www.ncbi.nlm.nih.gov/gene/?term=9777 dJ836N17.2 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026514 9777 TM9SF4 http://www.ncbi.nlm.nih.gov/gene/?term=9777 dJ836N17.2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026515 97783 C76336 http://www.ncbi.nlm.nih.gov/gene/?term=97783 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026516 97784 C76472 http://www.ncbi.nlm.nih.gov/gene/?term=97784 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026517 97787 C76872 http://www.ncbi.nlm.nih.gov/gene/?term=97787 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026518 9778 KIAA0232 http://www.ncbi.nlm.nih.gov/gene/?term=9778 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026519 9779 TBC1D5 http://www.ncbi.nlm.nih.gov/gene/?term=9779 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026520 9779 TBC1D5 http://www.ncbi.nlm.nih.gov/gene/?term=9779 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026521 9779 TBC1D5 http://www.ncbi.nlm.nih.gov/gene/?term=9779 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026522 977 CD151 http://www.ncbi.nlm.nih.gov/gene/?term=977 "GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026523 977 CD151 http://www.ncbi.nlm.nih.gov/gene/?term=977 "GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026524 9780 PIEZO1 http://www.ncbi.nlm.nih.gov/gene/?term=9780 "DHS, FAM38A, Mib " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026525 97820 4833439L19Rik http://www.ncbi.nlm.nih.gov/gene/?term=97820 "4930558H15Rik, C81457, Kiaa1191, P33monox " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026526 9782 MATR3 http://www.ncbi.nlm.nih.gov/gene/?term=9782 "ALS21, MPD2, VCPDM " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026527 9783 RIMS3 http://www.ncbi.nlm.nih.gov/gene/?term=9783 "NIM3, RIM3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026528 9784 SNX17 http://www.ncbi.nlm.nih.gov/gene/?term=9784 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026529 9785 DHX38 http://www.ncbi.nlm.nih.gov/gene/?term=9785 "DDX38, PRP16, PRPF16 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026530 97863 Fam8a1 http://www.ncbi.nlm.nih.gov/gene/?term=97863 C78339 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026531 9787 DLGAP5 http://www.ncbi.nlm.nih.gov/gene/?term=9787 "DLG7, HURP " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026532 9787 DLGAP5 http://www.ncbi.nlm.nih.gov/gene/?term=9787 "DLG7, HURP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026533 97884 B3galnt2 http://www.ncbi.nlm.nih.gov/gene/?term=97884 "A930105D20Rik, C80633, D230016N13Rik " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026534 9789 SPCS2 http://www.ncbi.nlm.nih.gov/gene/?term=9789 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026535 9789 SPCS2 http://www.ncbi.nlm.nih.gov/gene/?term=9789 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026536 9791 PTDSS1 http://www.ncbi.nlm.nih.gov/gene/?term=9791 "LMHD, PSS1, PSSA " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026537 9791 PTDSS1 http://www.ncbi.nlm.nih.gov/gene/?term=9791 "LMHD, PSS1, PSSA " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026538 9792 SERTAD2 http://www.ncbi.nlm.nih.gov/gene/?term=9792 "Sei-2, TRIP-Br2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026539 9792 SERTAD2 http://www.ncbi.nlm.nih.gov/gene/?term=9792 "Sei-2, TRIP-Br2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026540 9793 CKAP5 http://www.ncbi.nlm.nih.gov/gene/?term=9793 "CHTOG, MSPS, TOG, TOGp, ch-TOG " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026541 9793 CKAP5 http://www.ncbi.nlm.nih.gov/gene/?term=9793 "CHTOG, MSPS, TOG, TOGp, ch-TOG " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026542 9794 MAML1 http://www.ncbi.nlm.nih.gov/gene/?term=9794 "Mam-1, Mam1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026543 9794 MAML1 http://www.ncbi.nlm.nih.gov/gene/?term=9794 "Mam-1, Mam1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026544 9797 TATDN2 http://www.ncbi.nlm.nih.gov/gene/?term=9797 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026545 9798 IST1 http://www.ncbi.nlm.nih.gov/gene/?term=9798 OLC1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026546 97 ACYP1 http://www.ncbi.nlm.nih.gov/gene/?term=97 ACYPE mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026547 98013 C78549 http://www.ncbi.nlm.nih.gov/gene/?term=98013 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026548 9801 MRPL19 http://www.ncbi.nlm.nih.gov/gene/?term=9801 "L19mt, MRP-L15, MRP-L19, MRPL15, RLX1, RPML15 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026549 9801 MRPL19 http://www.ncbi.nlm.nih.gov/gene/?term=9801 "L19mt, MRP-L15, MRP-L19, MRPL15, RLX1, RPML15 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026550 9802 DAZAP2 http://www.ncbi.nlm.nih.gov/gene/?term=9802 PRTB mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026551 9802 DAZAP2 http://www.ncbi.nlm.nih.gov/gene/?term=9802 PRTB mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026552 9804 TOMM20 http://www.ncbi.nlm.nih.gov/gene/?term=9804 "MAS20, MOM19, TOM20 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026553 9804 TOMM20 http://www.ncbi.nlm.nih.gov/gene/?term=9804 "MAS20, MOM19, TOM20 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026554 9805 SCRN1 http://www.ncbi.nlm.nih.gov/gene/?term=9805 SES1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026555 9805 SCRN1 http://www.ncbi.nlm.nih.gov/gene/?term=9805 SES1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026556 9805 SCRN1 http://www.ncbi.nlm.nih.gov/gene/?term=9805 SES1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026557 9806 SPOCK2 http://www.ncbi.nlm.nih.gov/gene/?term=9806 testican-2 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026558 9807 IP6K1 http://www.ncbi.nlm.nih.gov/gene/?term=9807 "IHPK1, PiUS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026559 9807 IP6K1 http://www.ncbi.nlm.nih.gov/gene/?term=9807 "IHPK1, PiUS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026560 9810 RNF40 http://www.ncbi.nlm.nih.gov/gene/?term=9810 "BRE1B, RBP95, STARING " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026561 9810 RNF40 http://www.ncbi.nlm.nih.gov/gene/?term=9810 "BRE1B, RBP95, STARING " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026562 9811 CTIF http://www.ncbi.nlm.nih.gov/gene/?term=9811 "Gm672, KIAA0427 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026563 9812 KIAA0141 http://www.ncbi.nlm.nih.gov/gene/?term=9812 DELE mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026564 9812 KIAA0141 http://www.ncbi.nlm.nih.gov/gene/?term=9812 DELE mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026565 9813 EFCAB14 http://www.ncbi.nlm.nih.gov/gene/?term=9813 KIAA0494 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026566 98146 C78505 http://www.ncbi.nlm.nih.gov/gene/?term=98146 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026567 9816 URB2 http://www.ncbi.nlm.nih.gov/gene/?term=9816 "KIAA0133, NET10, NPA2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026568 9816 URB2 http://www.ncbi.nlm.nih.gov/gene/?term=9816 "KIAA0133, NET10, NPA2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026569 98170 Tmem132a http://www.ncbi.nlm.nih.gov/gene/?term=98170 "6720481D13Rik, Hspa5bp1, Orai1, R74613 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026570 9817 KEAP1 http://www.ncbi.nlm.nih.gov/gene/?term=9817 "INrf2, KLHL19 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026571 9817 KEAP1 http://www.ncbi.nlm.nih.gov/gene/?term=9817 "INrf2, KLHL19 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026572 9817 KEAP1 http://www.ncbi.nlm.nih.gov/gene/?term=9817 "INrf2, KLHL19 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026573 9818 NUP58 http://www.ncbi.nlm.nih.gov/gene/?term=9818 "NUP45, NUPL1, PRO2463 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026574 9819 TSC22D2 http://www.ncbi.nlm.nih.gov/gene/?term=9819 "TILZ4a, TILZ4b, TILZ4c " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026575 9819 TSC22D2 http://www.ncbi.nlm.nih.gov/gene/?term=9819 "TILZ4a, TILZ4b, TILZ4c " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026576 9820 CUL7 http://www.ncbi.nlm.nih.gov/gene/?term=9820 "3M1, KIAA0076, dJ20C7.5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026577 9821 RB1CC1 http://www.ncbi.nlm.nih.gov/gene/?term=9821 "ATG17, CC1, FIP200, PPP1R131 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026578 9824 ARHGAP11A http://www.ncbi.nlm.nih.gov/gene/?term=9824 GAP (1-12) mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026579 9824 ARHGAP11A http://www.ncbi.nlm.nih.gov/gene/?term=9824 GAP (1-12) mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026580 9824 ARHGAP11A http://www.ncbi.nlm.nih.gov/gene/?term=9824 GAP (1-12) mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026581 98267 Stk17b http://www.ncbi.nlm.nih.gov/gene/?term=98267 "3110009A03Rik, AI120141, Drak2 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026582 9826 ARHGEF11 http://www.ncbi.nlm.nih.gov/gene/?term=9826 "GTRAP48, PDZ-RHOGEF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026583 9826 ARHGEF11 http://www.ncbi.nlm.nih.gov/gene/?term=9826 "GTRAP48, PDZ-RHOGEF " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026584 9827 RGP1 http://www.ncbi.nlm.nih.gov/gene/?term=9827 KIAA0258 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026585 9828 ARHGEF17 http://www.ncbi.nlm.nih.gov/gene/?term=9828 "P164RHOGEF, TEM4, p164-RhoGEF " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026586 9829 DNAJC6 http://www.ncbi.nlm.nih.gov/gene/?term=9829 "DJC6, PARK19 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026587 98303 D630023F18Rik http://www.ncbi.nlm.nih.gov/gene/?term=98303 AI314969 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026588 9830 TRIM14 http://www.ncbi.nlm.nih.gov/gene/?term=9830 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026589 9830 TRIM14 http://www.ncbi.nlm.nih.gov/gene/?term=9830 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026590 9832 JAKMIP2 http://www.ncbi.nlm.nih.gov/gene/?term=9832 "JAMIP2, NECC1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026591 98365 Slamf9 http://www.ncbi.nlm.nih.gov/gene/?term=98365 "2310026I04Rik, AI462096, CD2F-10, CD84-H1, Cd2f10, SF2001 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026592 9837 GINS1 http://www.ncbi.nlm.nih.gov/gene/?term=9837 PSF1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026593 9837 GINS1 http://www.ncbi.nlm.nih.gov/gene/?term=9837 PSF1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026594 98386 Lbr http://www.ncbi.nlm.nih.gov/gene/?term=98386 "AI505894, ic " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026595 9839 ZEB2 http://www.ncbi.nlm.nih.gov/gene/?term=9839 "HSPC082, SIP-1, SIP1, SMADIP1, ZFHX1B " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026596 983 CDK1 http://www.ncbi.nlm.nih.gov/gene/?term=983 "CDC2, CDC28A, P34CDC2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026597 983 CDK1 http://www.ncbi.nlm.nih.gov/gene/?term=983 "CDC2, CDC28A, P34CDC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026598 98415 Nucks1 http://www.ncbi.nlm.nih.gov/gene/?term=98415 "2700010L10Rik, 8430423A01Rik, AI647518, C78391, Nucks " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026599 9842 PLEKHM1 http://www.ncbi.nlm.nih.gov/gene/?term=9842 "AP162, B2, OPTB6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026600 9843 HEPH http://www.ncbi.nlm.nih.gov/gene/?term=9843 CPL mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026601 9843 HEPH http://www.ncbi.nlm.nih.gov/gene/?term=9843 CPL mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026602 9844 ELMO1 http://www.ncbi.nlm.nih.gov/gene/?term=9844 "CED-12, CED12, ELMO-1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026603 9847 C2CD5 http://www.ncbi.nlm.nih.gov/gene/?term=9847 "CDP138, KIAA0528 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026604 9849 ZNF518A http://www.ncbi.nlm.nih.gov/gene/?term=9849 ZNF518 lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026605 9849 ZNF518A http://www.ncbi.nlm.nih.gov/gene/?term=9849 ZNF518 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026606 9853 RUSC2 http://www.ncbi.nlm.nih.gov/gene/?term=9853 Iporin mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026607 9854 C2CD2L http://www.ncbi.nlm.nih.gov/gene/?term=9854 "DLNB23, TMEM24 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026608 9857 CEP350 http://www.ncbi.nlm.nih.gov/gene/?term=9857 "CAP350, GM133 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026609 9857 CEP350 http://www.ncbi.nlm.nih.gov/gene/?term=9857 "CAP350, GM133 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026610 9858 PPP1R26 http://www.ncbi.nlm.nih.gov/gene/?term=9858 KIAA0649 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026611 9858 PPP1R26 http://www.ncbi.nlm.nih.gov/gene/?term=9858 KIAA0649 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026612 9859 CEP170 http://www.ncbi.nlm.nih.gov/gene/?term=9859 "FAM68A, KAB, KIAA0470 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026613 9859 CEP170 http://www.ncbi.nlm.nih.gov/gene/?term=9859 "FAM68A, KAB, KIAA0470 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026614 9860 LRIG2 http://www.ncbi.nlm.nih.gov/gene/?term=9860 "LIG-2, LIG2, UFS2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026615 9860 LRIG2 http://www.ncbi.nlm.nih.gov/gene/?term=9860 "LIG-2, LIG2, UFS2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026616 9861 PSMD6 http://www.ncbi.nlm.nih.gov/gene/?term=9861 "Rpn7, S10, SGA-113M, p42A, p44S10 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026617 9862 MED24 http://www.ncbi.nlm.nih.gov/gene/?term=9862 "ARC100, CRSP100, CRSP4, DRIP100, MED5, THRAP4, TRAP100 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026618 9862 MED24 http://www.ncbi.nlm.nih.gov/gene/?term=9862 "ARC100, CRSP100, CRSP4, DRIP100, MED5, THRAP4, TRAP100 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026619 9867 PJA2 http://www.ncbi.nlm.nih.gov/gene/?term=9867 "Neurodap1, RNF131 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026620 9867 PJA2 http://www.ncbi.nlm.nih.gov/gene/?term=9867 "Neurodap1, RNF131 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026621 98685 Trmt1l http://www.ncbi.nlm.nih.gov/gene/?term=98685 "1190005F20Rik, AW226554, C1orf25, Trm1-like, Trm1l " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026622 9868 TOMM70 http://www.ncbi.nlm.nih.gov/gene/?term=9868 "TOMM70A, Tom70 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026623 9868 TOMM70 http://www.ncbi.nlm.nih.gov/gene/?term=9868 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026624 9869 SETDB1 http://www.ncbi.nlm.nih.gov/gene/?term=9869 "ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026625 9870 AREL1 http://www.ncbi.nlm.nih.gov/gene/?term=9870 KIAA0317 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026626 9870 AREL1 http://www.ncbi.nlm.nih.gov/gene/?term=9870 KIAA0317 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026627 98711 Rdh10 http://www.ncbi.nlm.nih.gov/gene/?term=98711 "3110069K09Rik, 4921506A21Rik, AI875664, AW549993, D1Ertd762e, m366Asp " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026628 9871 SEC24D http://www.ncbi.nlm.nih.gov/gene/?term=9871 CLCRP2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026629 9871 SEC24D http://www.ncbi.nlm.nih.gov/gene/?term=9871 CLCRP2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026630 98732 Rab3gap2 http://www.ncbi.nlm.nih.gov/gene/?term=98732 "1110059F07Rik, 2010002H18Rik, 5830469C09, AI851069, AW743433, RAB3-GAP150, mKIAA0839 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026631 98733 Obsl1 http://www.ncbi.nlm.nih.gov/gene/?term=98733 AW822216 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026632 9873 FCHSD2 http://www.ncbi.nlm.nih.gov/gene/?term=9873 "NWK, SH3MD3 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026633 9874 TLK1 http://www.ncbi.nlm.nih.gov/gene/?term=9874 PKU-beta mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026634 98758 Hnrnpf http://www.ncbi.nlm.nih.gov/gene/?term=98758 "4833420I20Rik, AA407306, Hnrpf " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026635 9875 URB1 http://www.ncbi.nlm.nih.gov/gene/?term=9875 "C21orf108, NPA1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026636 9875 URB1 http://www.ncbi.nlm.nih.gov/gene/?term=9875 "C21orf108, NPA1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026637 9877 ZC3H11A http://www.ncbi.nlm.nih.gov/gene/?term=9877 ZC3HDC11A mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026638 9877 ZC3H11A http://www.ncbi.nlm.nih.gov/gene/?term=9877 ZC3HDC11A mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026639 9878 TOX4 http://www.ncbi.nlm.nih.gov/gene/?term=9878 "C14orf92, KIAA0737, LCP1, MIG7 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026640 9878 TOX4 http://www.ncbi.nlm.nih.gov/gene/?term=9878 "C14orf92, KIAA0737, LCP1, MIG7 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026641 9878 TOX4 http://www.ncbi.nlm.nih.gov/gene/?term=9878 "C14orf92, KIAA0737, LCP1, MIG7 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026642 9879 DDX46 http://www.ncbi.nlm.nih.gov/gene/?term=9879 "PRPF5, Prp5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026643 987 LRBA http://www.ncbi.nlm.nih.gov/gene/?term=987 "BGL, CDC4L, CVID8, LAB300, LBA " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026644 987 LRBA http://www.ncbi.nlm.nih.gov/gene/?term=987 "BGL, CDC4L, CVID8, LAB300, LBA " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026645 9880 ZBTB39 http://www.ncbi.nlm.nih.gov/gene/?term=9880 ZNF922 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026646 9881 TRANK1 http://www.ncbi.nlm.nih.gov/gene/?term=9881 LBA1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026647 9882 TBC1D4 http://www.ncbi.nlm.nih.gov/gene/?term=9882 "AS160, NIDDM5 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026648 9882 TBC1D4 http://www.ncbi.nlm.nih.gov/gene/?term=9882 "AS160, NIDDM5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026649 9883 POM121 http://www.ncbi.nlm.nih.gov/gene/?term=9883 "P145, POM121A " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026650 9885 OSBPL2 http://www.ncbi.nlm.nih.gov/gene/?term=9885 "DFNA67, DNFA67, ORP-2, ORP2 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026651 9885 OSBPL2 http://www.ncbi.nlm.nih.gov/gene/?term=9885 "DFNA67, DNFA67, ORP-2, ORP2 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026652 9885 OSBPL2 http://www.ncbi.nlm.nih.gov/gene/?term=9885 "DFNA67, DNFA67, ORP-2, ORP2 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026653 9886 RHOBTB1 http://www.ncbi.nlm.nih.gov/gene/?term=9886 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026654 98878 Ehd4 http://www.ncbi.nlm.nih.gov/gene/?term=98878 "2210022F10Rik, AI197390, AI846352, AV006278, Past2 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026655 9887 SMG7 http://www.ncbi.nlm.nih.gov/gene/?term=9887 "C1orf16, EST1C, SGA56M " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026656 9887 SMG7 http://www.ncbi.nlm.nih.gov/gene/?term=9887 "C1orf16, EST1C, SGA56M " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026657 9887 SMG7 http://www.ncbi.nlm.nih.gov/gene/?term=9887 "C1orf16, EST1C, SGA56M " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026658 988 CDC5L http://www.ncbi.nlm.nih.gov/gene/?term=988 "CDC5, CDC5-LIKE, CEF1, PCDC5RP, dJ319D22.1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026659 988 CDC5L http://www.ncbi.nlm.nih.gov/gene/?term=988 "CDC5, CDC5-LIKE, CEF1, PCDC5RP, dJ319D22.1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026660 988 CDC5L http://www.ncbi.nlm.nih.gov/gene/?term=988 "CDC5, CDC5-LIKE, CEF1, PCDC5RP, dJ319D22.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026661 9894 TELO2 http://www.ncbi.nlm.nih.gov/gene/?term=9894 "CLK2, TEL2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026662 9895 TECPR2 http://www.ncbi.nlm.nih.gov/gene/?term=9895 "KIAA0329, SPG49 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026663 9896 FIG4 http://www.ncbi.nlm.nih.gov/gene/?term=9896 "ALS11, BTOP, CMT4J, KIAA0274, SAC3, YVS, dJ249I4.1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026664 9897 KIAA0196 http://www.ncbi.nlm.nih.gov/gene/?term=9897 "RTSC, RTSC1, SPG8 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026665 9897 KIAA0196 http://www.ncbi.nlm.nih.gov/gene/?term=9897 "RTSC, RTSC1, SPG8 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026666 9897 KIAA0196 http://www.ncbi.nlm.nih.gov/gene/?term=9897 "RTSC, RTSC1, SPG8 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026667 9897 KIAA0196 http://www.ncbi.nlm.nih.gov/gene/?term=9897 "RTSC, RTSC1, SPG8 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026668 98985 Clp1 http://www.ncbi.nlm.nih.gov/gene/?term=98985 "AI462438, Heab " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026669 9898 UBAP2L http://www.ncbi.nlm.nih.gov/gene/?term=9898 "NICE-4, NICE4 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026670 9898 UBAP2L http://www.ncbi.nlm.nih.gov/gene/?term=9898 "NICE-4, NICE4 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026671 9899 SV2B http://www.ncbi.nlm.nih.gov/gene/?term=9899 HsT19680 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026672 98 ACYP2 http://www.ncbi.nlm.nih.gov/gene/?term=98 "ACYM, ACYP " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026673 99003 Qser1 http://www.ncbi.nlm.nih.gov/gene/?term=99003 "4732486I23Rik, AI502974 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026674 9901 SRGAP3 http://www.ncbi.nlm.nih.gov/gene/?term=9901 "ARHGAP14, MEGAP, SRGAP2, WRP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026675 9902 MRC2 http://www.ncbi.nlm.nih.gov/gene/?term=9902 "CD280, CLEC13E, ENDO180, UPARAP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026676 99031 Osbpl6 http://www.ncbi.nlm.nih.gov/gene/?term=99031 "1110062M20Rik, AI596402, ORP-6, mKIAA4128 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026677 9903 KLHL21 http://www.ncbi.nlm.nih.gov/gene/?term=9903 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026678 99045 Mrps26 http://www.ncbi.nlm.nih.gov/gene/?term=99045 "AI648866, GI008, MRP-S13, MRP-S26, Rpms13 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026679 9905 SGSM2 http://www.ncbi.nlm.nih.gov/gene/?term=9905 RUTBC1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026680 9908 G3BP2 http://www.ncbi.nlm.nih.gov/gene/?term=9908 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026681 9908 G3BP2 http://www.ncbi.nlm.nih.gov/gene/?term=9908 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026682 9908 G3BP2 http://www.ncbi.nlm.nih.gov/gene/?term=9908 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026683 9909 DENND4B http://www.ncbi.nlm.nih.gov/gene/?term=9909 KIAA0476 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026684 990 CDC6 http://www.ncbi.nlm.nih.gov/gene/?term=990 "CDC18L, HsCDC18, HsCDC6 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026685 990 CDC6 http://www.ncbi.nlm.nih.gov/gene/?term=990 "CDC18L, HsCDC18, HsCDC6 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026686 990 CDC6 http://www.ncbi.nlm.nih.gov/gene/?term=990 "CDC18L, HsCDC18, HsCDC6 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026687 990 CDC6 http://www.ncbi.nlm.nih.gov/gene/?term=990 "CDC18L, HsCDC18, HsCDC6 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026688 990 CDC6 http://www.ncbi.nlm.nih.gov/gene/?term=990 "CDC18L, HsCDC18, HsCDC6 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026689 9910 RABGAP1L http://www.ncbi.nlm.nih.gov/gene/?term=9910 "HHL, TBC1D18 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026690 9910 RABGAP1L http://www.ncbi.nlm.nih.gov/gene/?term=9910 "HHL, TBC1D18 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026691 99138 Stard7 http://www.ncbi.nlm.nih.gov/gene/?term=99138 "AI852671, AL022671, AW544915 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026692 9913 SUPT7L http://www.ncbi.nlm.nih.gov/gene/?term=9913 "SPT7L, STAF65, STAF65(gamma), STAF65G, SUPT7H " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026693 9913 SUPT7L http://www.ncbi.nlm.nih.gov/gene/?term=9913 "SPT7L, STAF65, STAF65(gamma), STAF65G, SUPT7H " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026694 9913 SUPT7L http://www.ncbi.nlm.nih.gov/gene/?term=9913 "SPT7L, STAF65, STAF65(gamma), STAF65G, SUPT7H " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026695 9913 SUPT7L http://www.ncbi.nlm.nih.gov/gene/?term=9913 "SPT7L, STAF65, STAF65(gamma), STAF65G, SUPT7H " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026696 9914 ATP2C2 http://www.ncbi.nlm.nih.gov/gene/?term=9914 SPCA2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026697 9915 ARNT2 http://www.ncbi.nlm.nih.gov/gene/?term=9915 "WEDAS, bHLHe1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026698 99167 Ssx2ip http://www.ncbi.nlm.nih.gov/gene/?term=99167 "AU014939, AU042321, Adip " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026699 9917 FAM20B http://www.ncbi.nlm.nih.gov/gene/?term=9917 gxk1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026700 9917 FAM20B http://www.ncbi.nlm.nih.gov/gene/?term=9917 gxk1 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026701 9917 FAM20B http://www.ncbi.nlm.nih.gov/gene/?term=9917 gxk1 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026702 9917 FAM20B http://www.ncbi.nlm.nih.gov/gene/?term=9917 gxk1 mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026703 9918 NCAPD2 http://www.ncbi.nlm.nih.gov/gene/?term=9918 "CAP-D2, CNAP1, hCAP-D2 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026704 9919 SEC16A http://www.ncbi.nlm.nih.gov/gene/?term=9919 "KIAA0310, SEC16L, p250 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026705 9919 SEC16A http://www.ncbi.nlm.nih.gov/gene/?term=9919 "KIAA0310, SEC16L, p250 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026706 991 CDC20 http://www.ncbi.nlm.nih.gov/gene/?term=991 "CDC20A, bA276H19.3, p55CDC " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026707 9921 RNF10 http://www.ncbi.nlm.nih.gov/gene/?term=9921 RIE2 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026708 9921 RNF10 http://www.ncbi.nlm.nih.gov/gene/?term=9921 RIE2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026709 9923 ZBTB40 http://www.ncbi.nlm.nih.gov/gene/?term=9923 ZNF923 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026710 9923 ZBTB40 http://www.ncbi.nlm.nih.gov/gene/?term=9923 ZNF923 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026711 9923 ZBTB40 http://www.ncbi.nlm.nih.gov/gene/?term=9923 ZNF923 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026712 9924 PAN2 http://www.ncbi.nlm.nih.gov/gene/?term=9924 USP52 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026713 9925 ZBTB5 http://www.ncbi.nlm.nih.gov/gene/?term=9925 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026714 9926 LPGAT1 http://www.ncbi.nlm.nih.gov/gene/?term=9926 "FAM34A, FAM34A1, NET8 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026715 9926 LPGAT1 http://www.ncbi.nlm.nih.gov/gene/?term=9926 "FAM34A, FAM34A1, NET8 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026716 9926 LPGAT1 http://www.ncbi.nlm.nih.gov/gene/?term=9926 "FAM34A, FAM34A1, NET8 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026717 9926 LPGAT1 http://www.ncbi.nlm.nih.gov/gene/?term=9926 "FAM34A, FAM34A1, NET8 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026718 9927 MFN2 http://www.ncbi.nlm.nih.gov/gene/?term=9927 "CMT2A, CMT2A2, CPRP1, HMSN6A, HSG, MARF " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026719 9928 KIF14 http://www.ncbi.nlm.nih.gov/gene/?term=9928 MKS12 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026720 9928 KIF14 http://www.ncbi.nlm.nih.gov/gene/?term=9928 MKS12 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026721 9929 JOSD1 http://www.ncbi.nlm.nih.gov/gene/?term=9929 dJ508I15.2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026722 9929 JOSD1 http://www.ncbi.nlm.nih.gov/gene/?term=9929 dJ508I15.2 mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026723 9929 JOSD1 http://www.ncbi.nlm.nih.gov/gene/?term=9929 dJ508I15.2 mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026724 9929 JOSD1 http://www.ncbi.nlm.nih.gov/gene/?term=9929 dJ508I15.2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026725 9931 HELZ http://www.ncbi.nlm.nih.gov/gene/?term=9931 "DHRC, DRHC, HUMORF5 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026726 9931 HELZ http://www.ncbi.nlm.nih.gov/gene/?term=9931 "DHRC, DRHC, HUMORF5 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026727 9931 HELZ http://www.ncbi.nlm.nih.gov/gene/?term=9931 "DHRC, DRHC, HUMORF5 " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026728 9931 HELZ http://www.ncbi.nlm.nih.gov/gene/?term=9931 "DHRC, DRHC, HUMORF5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026729 9933 PUM3 http://www.ncbi.nlm.nih.gov/gene/?term=9933 "HA-8, HLA-HA8, KIAA0020, PEN, PUF-A, PUF6, XTP5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026730 9936 CD302 http://www.ncbi.nlm.nih.gov/gene/?term=9936 "BIMLEC, CLEC13A, DCL-1, DCL1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026731 99375 Cul4a http://www.ncbi.nlm.nih.gov/gene/?term=99375 "2810470J21Rik, AW495282 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026732 9937 DCLRE1A http://www.ncbi.nlm.nih.gov/gene/?term=9937 "PSO2, SNM1, SNM1A " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026733 9937 DCLRE1A http://www.ncbi.nlm.nih.gov/gene/?term=9937 "PSO2, SNM1, SNM1A " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026734 99382 Abtb2 http://www.ncbi.nlm.nih.gov/gene/?term=99382 "AW539457, BPOZ-2 " mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026735 9939 RBM8A http://www.ncbi.nlm.nih.gov/gene/?term=9939 "BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026736 9939 RBM8A http://www.ncbi.nlm.nih.gov/gene/?term=9939 "BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026737 993 CDC25A http://www.ncbi.nlm.nih.gov/gene/?term=993 CDC25A2 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026738 993 CDC25A http://www.ncbi.nlm.nih.gov/gene/?term=993 CDC25A2 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026739 99413 AW555355 http://www.ncbi.nlm.nih.gov/gene/?term=99413 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026740 99413 AW555355 http://www.ncbi.nlm.nih.gov/gene/?term=99413 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026741 9943 OXSR1 http://www.ncbi.nlm.nih.gov/gene/?term=9943 OSR1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026742 9943 OXSR1 http://www.ncbi.nlm.nih.gov/gene/?term=9943 OSR1 mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026743 9943 OXSR1 http://www.ncbi.nlm.nih.gov/gene/?term=9943 OSR1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026744 99458 BB166591 http://www.ncbi.nlm.nih.gov/gene/?term=99458 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026745 99470 Magi3 http://www.ncbi.nlm.nih.gov/gene/?term=99470 "4732496O19Rik, 6530407C02Rik, AA407180, AI120132, mKIAA1634 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026746 99480 Dnttip2 http://www.ncbi.nlm.nih.gov/gene/?term=99480 "4930588M11Rik, AA408582, AU014960, HSU15552 " mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026747 9948 WDR1 http://www.ncbi.nlm.nih.gov/gene/?term=9948 "AIP1, HEL-S-52, NORI-1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026748 9949 AMMECR1 http://www.ncbi.nlm.nih.gov/gene/?term=9949 AMMERC1 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026749 9949 AMMECR1 http://www.ncbi.nlm.nih.gov/gene/?term=9949 AMMERC1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026750 994 CDC25B http://www.ncbi.nlm.nih.gov/gene/?term=994 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026751 994 CDC25B http://www.ncbi.nlm.nih.gov/gene/?term=994 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026752 9953 HS3ST3B1 http://www.ncbi.nlm.nih.gov/gene/?term=9953 "3-OST-3B, 3OST3B1, h3-OST-3B " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026753 9955 HS3ST3A1 http://www.ncbi.nlm.nih.gov/gene/?term=9955 "3-OST-3A, 3OST3A1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026754 99586 Dpyd http://www.ncbi.nlm.nih.gov/gene/?term=99586 "AI315208, DPD, E330028L06Rik " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026755 9958 USP15 http://www.ncbi.nlm.nih.gov/gene/?term=9958 "UNPH-2, UNPH4 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026756 9958 USP15 http://www.ncbi.nlm.nih.gov/gene/?term=9958 "UNPH-2, UNPH4 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026757 995 CDC25C http://www.ncbi.nlm.nih.gov/gene/?term=995 "CDC25, PPP1R60 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026758 995 CDC25C http://www.ncbi.nlm.nih.gov/gene/?term=995 "CDC25, PPP1R60 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026759 9960 USP3 http://www.ncbi.nlm.nih.gov/gene/?term=9960 "SIH003, UBP " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026760 9961 MVP http://www.ncbi.nlm.nih.gov/gene/?term=9961 "LRP, VAULT1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026761 9961 MVP http://www.ncbi.nlm.nih.gov/gene/?term=9961 "LRP, VAULT1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026762 9962 SLC23A2 http://www.ncbi.nlm.nih.gov/gene/?term=9962 "NBTL1, SLC23A1, SVCT2, YSPL2, hSVCT2 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026763 9962 SLC23A2 http://www.ncbi.nlm.nih.gov/gene/?term=9962 "NBTL1, SLC23A1, SVCT2, YSPL2 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026764 99633 Adgrl2 http://www.ncbi.nlm.nih.gov/gene/?term=99633 "AI450192, CIRL-2, Gm619, Lec1, Lphh1, Lphn2, mKIAA0786 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026765 9967 THRAP3 http://www.ncbi.nlm.nih.gov/gene/?term=9967 TRAP150 mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026766 9967 THRAP3 http://www.ncbi.nlm.nih.gov/gene/?term=9967 TRAP150 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026767 99683 Sec24b http://www.ncbi.nlm.nih.gov/gene/?term=99683 "AI605202, SEC24 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026768 9968 MED12 http://www.ncbi.nlm.nih.gov/gene/?term=9968 "ARC240, CAGH45, FGS1, HOPA, MED12S, OHDOX, OKS, OPA1, TNRC11, TRAP230 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026769 9969 MED13 http://www.ncbi.nlm.nih.gov/gene/?term=9969 "ARC250, DRIP250, HSPC221, THRAP1, TRAP240 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026770 9969 MED13 http://www.ncbi.nlm.nih.gov/gene/?term=9969 "ARC250, DRIP250, HSPC221, THRAP1, TRAP240 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026771 996 CDC27 http://www.ncbi.nlm.nih.gov/gene/?term=996 "ANAPC3, APC3Hs, D0S1430E, D17S978E, H-NUC, HNUC, NUC2, CDC27 " mRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026772 996 CDC27 http://www.ncbi.nlm.nih.gov/gene/?term=996 "ANAPC3, APC3Hs, D0S1430E, D17S978E, H-NUC, HNUC, NUC2, CDC27 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026773 996 CDC27 http://www.ncbi.nlm.nih.gov/gene/?term=996 "ANAPC3, APC3, CDC27Hs, D0S1430E, D17S978E, H-NUC, HNUC, NUC2 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026774 99712 Cept1 http://www.ncbi.nlm.nih.gov/gene/?term=99712 "9930118K05Rik, mCEPT1 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026775 9972 NUP153 http://www.ncbi.nlm.nih.gov/gene/?term=9972 "HNUP153, N153 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026776 9972 NUP153 http://www.ncbi.nlm.nih.gov/gene/?term=9972 "HNUP153, N153 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026777 99730 Taf13 http://www.ncbi.nlm.nih.gov/gene/?term=99730 "1810004N01Rik, 2010309N11Rik, AI847295, TAFII18 " mRNA Mus musculus 24152552 Axon Motorneuron Microarray "To identify SMN-associated mRNAs in these repertoires, we compared our microarray data with the transcriptome analyses of (1) axons from dorsal root ganglion neurons (Willis et al. 2007), (2) uninjured and regenerating cortical axons (Taylor et al. 2009), and (3) embryonic and adult sensory axons (Gumy et al. 2011). This identified 75 localized mRNAs present in SMN complexes (Fig. 4). Data are collected from Figure 4: SMN interacts with a subset of mRNAs known to be localized in axons. " RLID00026778 9973 CCS http://www.ncbi.nlm.nih.gov/gene/?term=9973 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026779 9975 NR1D2 http://www.ncbi.nlm.nih.gov/gene/?term=9975 "BD73, EAR-1R, RVR " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026780 9975 NR1D2 http://www.ncbi.nlm.nih.gov/gene/?term=9975 "BD73, EAR-1R, RVR " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026781 9976 CLEC2B http://www.ncbi.nlm.nih.gov/gene/?term=9976 "AICL, CLECSF2, HP10085, IFNRG1 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026782 9978 RBX1 http://www.ncbi.nlm.nih.gov/gene/?term=9978 "BA554C12.1, RNF75, ROC1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026783 9978 RBX1 http://www.ncbi.nlm.nih.gov/gene/?term=9978 "BA554C12.1, RNF75, ROC1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026784 9978 RBX1 http://www.ncbi.nlm.nih.gov/gene/?term=9978 "BA554C12.1, RNF75, ROC1 " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026785 9978 RBX1 http://www.ncbi.nlm.nih.gov/gene/?term=9978 "BA554C12.1, RNF75, ROC1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026786 997 CDC34 http://www.ncbi.nlm.nih.gov/gene/?term=997 "E2-CDC34, UBC3, UBCH3, UBE2R1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026787 997 CDC34 http://www.ncbi.nlm.nih.gov/gene/?term=997 "E2-CDC34, UBC3, UBCH3, UBE2R1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026788 9982 FGFBP1 http://www.ncbi.nlm.nih.gov/gene/?term=9982 "FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026789 9984 THOC1 http://www.ncbi.nlm.nih.gov/gene/?term=9984 "HPR1, P84, P84N5 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026790 9986 RCE1 http://www.ncbi.nlm.nih.gov/gene/?term=9986 "FACE2A, RCE1B, RCE1 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026791 9987 HNRNPDL http://www.ncbi.nlm.nih.gov/gene/?term=9987 "HNRNP, HNRPDL, JKTBP, JKTBP2, LGMD1G, laAUF1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026792 9987 HNRNPDL http://www.ncbi.nlm.nih.gov/gene/?term=9987 "HNRNP, HNRPDL, JKTBP, JKTBP2, LGMD1G, laAUF1 " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026793 9987 HNRNPDL http://www.ncbi.nlm.nih.gov/gene/?term=9987 "HNRNP, HNRPDL, JKTBP, JKTBP2, LGMD1G, laAUF1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026794 99889 Arfip1 http://www.ncbi.nlm.nih.gov/gene/?term=99889 "2310030I10Rik, Arfaptin, D3Ertd598e " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026795 9988 DMTF1 http://www.ncbi.nlm.nih.gov/gene/?term=9988 "DMP1, DMTF, MRUL, hDMP1 " mRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026796 9989 PPP4R1 http://www.ncbi.nlm.nih.gov/gene/?term=9989 "MEG1, PP4(Rmeg), PP4R1 " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026797 998 CDC42 http://www.ncbi.nlm.nih.gov/gene/?term=998 "CDC42Hs, G25K, TKS " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026798 998 CDC42 http://www.ncbi.nlm.nih.gov/gene/?term=998 "CDC42Hs, G25K, TKS " mRNA Homo sapiens 22199352 Ribosome HEK293 cell Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00026799 998 CDC42 http://www.ncbi.nlm.nih.gov/gene/?term=998 "CDC42Hs, G25K, TKS " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026800 998 CDC42 http://www.ncbi.nlm.nih.gov/gene/?term=998 "CDC42Hs, G25K, TKS " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026801 998 CDC42 http://www.ncbi.nlm.nih.gov/gene/?term=998 "CDC42Hs, G25K, TKS " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026802 9990 SLC12A6 http://www.ncbi.nlm.nih.gov/gene/?term=9990 "ACCPN, KCC3, KCC3A, KCC3B " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026803 9990 SLC12A6 http://www.ncbi.nlm.nih.gov/gene/?term=9990 "ACCPN, KCC3, KCC3A, KCC3B " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026804 9991 PTBP3 http://www.ncbi.nlm.nih.gov/gene/?term=9991 ROD1 mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026805 99929 Tiparp http://www.ncbi.nlm.nih.gov/gene/?term=99929 "ARTD14, AW558171, PARP7 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026806 9993 DGCR2 http://www.ncbi.nlm.nih.gov/gene/?term=9993 "DGS-C, IDD, LAN, SEZ-12 " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026807 9993 DGCR2 http://www.ncbi.nlm.nih.gov/gene/?term=9993 "DGS-C, IDD, LAN, SEZ-12 " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026808 9994 CASP8AP2 http://www.ncbi.nlm.nih.gov/gene/?term=9994 "CED-4, FLASH, RIP25 " lncRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026809 9997 SCO2 http://www.ncbi.nlm.nih.gov/gene/?term=9997 "CEMCOX1, MYP6, SCO1L " mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00026810 99982 Kdm1a http://www.ncbi.nlm.nih.gov/gene/?term=99982 "1810043O07Rik, AA408884, Aof2, D4Ertd478e, Kdm1, Lsd1, mKIAA0601 " mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026811 999 CDH1 http://www.ncbi.nlm.nih.gov/gene/?term=999 "Arc-1, CD324, CDHE, ECAD, LCAM, UVO " mRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026812 999 CDH1 http://www.ncbi.nlm.nih.gov/gene/?term=999 "Arc-1, CD324, CDHE, ECAD, LCAM, UVO " mRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00026813 999 CDH1 http://www.ncbi.nlm.nih.gov/gene/?term=999 "Arc-1, CD324, CDHE, ECAD, LCAM, UVO " mRNA Homo sapiens 21613539 Endoplasmic reticulum Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026814 9 NAT1 http://www.ncbi.nlm.nih.gov/gene/?term=9 "AAC1, MNAT, NAT-1, NATI " mRNA Homo sapiens 21613539 Cytosol Myeloma cell qRT-PCR "The mRNA transcriptome is currently thought to be partitioned between the cytosol and endoplasmic reticulum (ER) compartments by binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. Data are collected from Supplemental Data - The gene lists selected by the described GO categories are listed. Gene ID and subcellular distribution values, in log2 as well as fractional ER enrichment are listed. " RLID00026815 AA153229 AA153229 http://www.ncbi.nlm.nih.gov/nuccore/AA153229 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026816 AA413531 AA413531 http://www.ncbi.nlm.nih.gov/nuccore/AA413531 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026817 AA690930 AA690930 http://www.ncbi.nlm.nih.gov/nuccore/AA690930 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026818 AA798895 AA798895 http://www.ncbi.nlm.nih.gov/nuccore/AA798895 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026819 AB048287 AB048287 http://www.ncbi.nlm.nih.gov/nuccore/AB048287 lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00026820 AB055854 AB055854 http://www.ncbi.nlm.nih.gov/nuccore/AB055854 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026821 AB116666 Khps1 http://www.ncbi.nlm.nih.gov/nuccore/AB116666 lncRNA Rattus norvegicus 15325271 Cytoplasm Liver|Brain In situ hybridization|Northern blot "The expression of Khps1 in the primary cell culture preparation from rat fetuses was investigated (Fig. 2D). Expression was detected in the cytoplasm as well as nuclei in some cells, indicating that Khps1 is exported to the cytoplasm. " RLID00026822 AB116666 Khps1 http://www.ncbi.nlm.nih.gov/nuccore/AB116666 lncRNA Rattus norvegicus 15325271 Nucleus Liver|Brain In situ hybridization|Northern blot "The expression of Khps1 in the primary cell culture preparation from rat fetuses was investigated (Fig. 2D). Expression was detected in the cytoplasm as well as nuclei in some cells, indicating that Khps1 is exported to the cytoplasm. " RLID00026823 AC008472 Alpha-250 http://www.ncbi.nlm.nih.gov/nuccore/AC008472 lncRNA Homo sapiens 7867928 Cytoplasm HeLa cell Binding assays "Although alpha-280 is detected among both the cells' nuclear and cytoplasmic RNAs, the great majority of alpha-250 is found in the cytoplasmic subcellular compartment. " RLID00026824 AC008472 Alpha-280 http://www.ncbi.nlm.nih.gov/nuccore/AC008472 lncRNA Homo sapiens 7867928 Nucleus HeLa cell Binding assays "Although alpha-280 is detected among both the cells' nuclear and cytoplasmic RNAs, the great majority of alpha-250 is found in the cytoplasmic subcellular compartment. As judged by its resistance to high concentrations of alpha-amanitin, cell-free transcription of alpha-250 and alpha-280 appears to involve RNA polymerase I. Tissue culture transfection and cell-free transcription experiments demonstrate that alpha-250 and alpha-280 stimulate S14 mRNA transcription, whereas free ribosomal protein S14 inhibits it. " RLID00026825 AC008472 Alpha-280 http://www.ncbi.nlm.nih.gov/nuccore/AC008472 lncRNA Homo sapiens 7867928 Cytoplasm HeLa cell Binding assays "Although alpha-280 is detected among both the cells' nuclear and cytoplasmic RNAs, the great majority of alpha-250 is found in the cytoplasmic subcellular compartment. As judged by its resistance to high concentrations of alpha-amanitin, cell-free transcription of alpha-250 and alpha-280 appears to involve RNA polymerase I. Tissue culture transfection and cell-free transcription experiments demonstrate that alpha-250 and alpha-280 stimulate S14 mRNA transcription, whereas free ribosomal protein S14 inhibits it. " RLID00026826 AF085738 AF085738 http://www.ncbi.nlm.nih.gov/nuccore/AF085738 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026827 AF145043 AF145043 http://www.ncbi.nlm.nih.gov/nuccore/?term=AF145043 Nerve growth factor(NGF) mRNA Cervus elaphus 17215957 Axon Antler In situ hybridization|Northern blot Denervation experiments suggested a causal relationship exists between NGF mRNA expression in arterial smooth muscle and sensory axons in the antler tip. RLID00026828 AI118114 AI118114 http://www.ncbi.nlm.nih.gov/nuccore/AI118114 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026829 AI326469 AI326469 http://www.ncbi.nlm.nih.gov/nuccore/AI326469 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026830 AI414004 AI414004 http://www.ncbi.nlm.nih.gov/nuccore/AI414004 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026831 AI447935 AI447935 http://www.ncbi.nlm.nih.gov/nuccore/AI447935 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026832 AI448156 AI448156 http://www.ncbi.nlm.nih.gov/nuccore/AI448156 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026833 AI481875 AI481875 http://www.ncbi.nlm.nih.gov/nuccore/AI481875 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026834 AI506532 AI506532 http://www.ncbi.nlm.nih.gov/nuccore/AI506532 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026835 AI506565 AI506565 http://www.ncbi.nlm.nih.gov/nuccore/AI506565 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026836 AI506888 AI506888 http://www.ncbi.nlm.nih.gov/nuccore/AI506888 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026837 AI585789 AI585789 http://www.ncbi.nlm.nih.gov/nuccore/AI585789 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026838 AI585995 AI585995 http://www.ncbi.nlm.nih.gov/nuccore/AI585995 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026839 AI606070 AI606070 http://www.ncbi.nlm.nih.gov/nuccore/AI606070 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026840 AI643819 AI643819 http://www.ncbi.nlm.nih.gov/nuccore/AI643819 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026841 AI648759 AI648759 http://www.ncbi.nlm.nih.gov/nuccore/AI648759 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026842 AI843353 AI843353 http://www.ncbi.nlm.nih.gov/nuccore/AI843353 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026843 AJ409505 AJ409505 http://www.ncbi.nlm.nih.gov/nuccore/AJ409505 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026844 AK003956 AK003956 http://www.ncbi.nlm.nih.gov/nuccore/?term=AK003956 mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00026845 AK006399 AK006399 http://www.ncbi.nlm.nih.gov/nuccore/AK006399 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026846 AK006751 AK006751 http://www.ncbi.nlm.nih.gov/nuccore/AK006751 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026847 AK012243 AK012243 http://www.ncbi.nlm.nih.gov/nuccore/AK012243 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026848 AK013287 AK013287 http://www.ncbi.nlm.nih.gov/nuccore/?term=AK013287 mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00026849 AK013702 AK013702 http://www.ncbi.nlm.nih.gov/nuccore/AK013702 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026850 AK015332 AK015332 http://www.ncbi.nlm.nih.gov/nuccore/AK015332 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026851 AK015425 AK015425 http://www.ncbi.nlm.nih.gov/nuccore/AK015425 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00026852 AK016846 AK016846 http://www.ncbi.nlm.nih.gov/nuccore/AK016846 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026853 AK020545 AK020545 http://www.ncbi.nlm.nih.gov/nuccore/AK020545 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026854 AK021084 AK021084 http://www.ncbi.nlm.nih.gov/nuccore/AK021084 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026855 AK028006 AK028006 http://www.ncbi.nlm.nih.gov/nuccore/AK028006 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026856 AK029643 AK029643 http://www.ncbi.nlm.nih.gov/nuccore/AK029643 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026857 AK031372 AK031372 http://www.ncbi.nlm.nih.gov/nuccore/AK031372 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026858 AK032119 AK032119 http://www.ncbi.nlm.nih.gov/nuccore/AK032119 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026859 AK032198 AK032198 http://www.ncbi.nlm.nih.gov/nuccore/AK032198 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026860 AK032433 AK032433 http://www.ncbi.nlm.nih.gov/nuccore/AK032433 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026861 AK032710 AK032710 http://www.ncbi.nlm.nih.gov/nuccore/AK032710 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026862 AK032810 AK032810 http://www.ncbi.nlm.nih.gov/nuccore/AK032810 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026863 AK032971 AK032971 http://www.ncbi.nlm.nih.gov/nuccore/AK032971 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026864 AK033359 AK033359 http://www.ncbi.nlm.nih.gov/nuccore/AK033359 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026865 AK033546 AK033546 http://www.ncbi.nlm.nih.gov/nuccore/AK033546 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026866 AK033881 AK033881 http://www.ncbi.nlm.nih.gov/nuccore/AK033881 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026867 AK034929 AK034929 http://www.ncbi.nlm.nih.gov/nuccore/AK034929 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026868 AK035021 AK035021 http://www.ncbi.nlm.nih.gov/nuccore/AK035021 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026869 AK035820 AK035820 http://www.ncbi.nlm.nih.gov/nuccore/AK035820 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026870 AK037080 AK037080 http://www.ncbi.nlm.nih.gov/nuccore/AK037080 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026871 AK038908 AK038908 http://www.ncbi.nlm.nih.gov/nuccore/AK038908 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026872 AK039317 AK039317 http://www.ncbi.nlm.nih.gov/nuccore/AK039317 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026873 AK039415 AK039415 http://www.ncbi.nlm.nih.gov/nuccore/AK039415 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026874 AK039687 AK039687 http://www.ncbi.nlm.nih.gov/nuccore/AK039687 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026875 AK039697 AK039697 http://www.ncbi.nlm.nih.gov/nuccore/AK039697 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026876 AK039862 AK039862 http://www.ncbi.nlm.nih.gov/nuccore/AK039862 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026877 AK039914 AK039914 http://www.ncbi.nlm.nih.gov/nuccore/AK039914 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026878 AK040695 AK040695 http://www.ncbi.nlm.nih.gov/nuccore/AK040695 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026879 AK041029 AK041029 http://www.ncbi.nlm.nih.gov/nuccore/AK041029 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026880 AK041105 AK041105 http://www.ncbi.nlm.nih.gov/nuccore/AK041105 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026881 AK041297 AK041297 http://www.ncbi.nlm.nih.gov/nuccore/AK041297 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026882 AK041799 AK041799 http://www.ncbi.nlm.nih.gov/nuccore/AK041799 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026883 AK042227 AK042227 http://www.ncbi.nlm.nih.gov/nuccore/AK042227 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026884 AK042390 AK042390 http://www.ncbi.nlm.nih.gov/nuccore/AK042390 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026885 AK042797 AK042797 http://www.ncbi.nlm.nih.gov/nuccore/AK042797 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026886 AK043453 AK043453 http://www.ncbi.nlm.nih.gov/nuccore/AK043453 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026887 AK043655 AK043655 http://www.ncbi.nlm.nih.gov/nuccore/AK043655 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026888 AK043715 AK043715 http://www.ncbi.nlm.nih.gov/nuccore/AK043715 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026889 AK043785 AK043785 http://www.ncbi.nlm.nih.gov/nuccore/AK043785 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026890 AK044354 AK044354 http://www.ncbi.nlm.nih.gov/nuccore/AK044354 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026891 AK044373 AK044373 http://www.ncbi.nlm.nih.gov/nuccore/AK044373 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026892 AK044844 AK044844 http://www.ncbi.nlm.nih.gov/nuccore/AK044844 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026893 AK045229 AK045229 http://www.ncbi.nlm.nih.gov/nuccore/AK045229 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026894 AK045243 AK045243 http://www.ncbi.nlm.nih.gov/nuccore/AK045243 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026895 AK045559 AK045559 http://www.ncbi.nlm.nih.gov/nuccore/AK045559 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026896 AK046710 AK046710 http://www.ncbi.nlm.nih.gov/nuccore/AK046710 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026897 AK046731 AK046731 http://www.ncbi.nlm.nih.gov/nuccore/AK046731 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026898 AK046917 AK046917 http://www.ncbi.nlm.nih.gov/nuccore/AK046917 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026899 AK047329 AK047329 http://www.ncbi.nlm.nih.gov/nuccore/AK047329 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026900 AK047560 AK047560 http://www.ncbi.nlm.nih.gov/nuccore/AK047560 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026901 AK047744 AK047744 http://www.ncbi.nlm.nih.gov/nuccore/AK047744 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026902 AK047802 AK047802 http://www.ncbi.nlm.nih.gov/nuccore/AK047802 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026903 AK048192 AK048192 http://www.ncbi.nlm.nih.gov/nuccore/AK048192 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026904 AK048225 AK048225 http://www.ncbi.nlm.nih.gov/nuccore/AK048225 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026905 AK048391 AK048391 http://www.ncbi.nlm.nih.gov/nuccore/AK048391 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026906 AK048510 AK048510 http://www.ncbi.nlm.nih.gov/nuccore/AK048510 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026907 AK048712 AK048712 http://www.ncbi.nlm.nih.gov/nuccore/AK048712 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026908 AK049451 AK049451 http://www.ncbi.nlm.nih.gov/nuccore/AK049451 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026909 AK049757 AK049757 http://www.ncbi.nlm.nih.gov/nuccore/AK049757 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026910 AK049962 AK049962 http://www.ncbi.nlm.nih.gov/nuccore/AK049962 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026911 AK050685 AK050685 http://www.ncbi.nlm.nih.gov/nuccore/AK050685 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026912 AK050712 AK050712 http://www.ncbi.nlm.nih.gov/nuccore/AK050712 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026913 AK051340 AK051340 http://www.ncbi.nlm.nih.gov/nuccore/AK051340 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026914 AK051554 AK051554 http://www.ncbi.nlm.nih.gov/nuccore/AK051554 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026915 AK051785 AK051785 http://www.ncbi.nlm.nih.gov/nuccore/AK051785 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026916 AK051928 AK051928 http://www.ncbi.nlm.nih.gov/nuccore/AK051928 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026917 AK052078 AK052078 http://www.ncbi.nlm.nih.gov/nuccore/AK052078 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026918 AK052349 AK052349 http://www.ncbi.nlm.nih.gov/nuccore/AK052349 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026919 AK053610 AK053610 http://www.ncbi.nlm.nih.gov/nuccore/AK053610 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026920 AK053770 AK053770 http://www.ncbi.nlm.nih.gov/nuccore/AK053770 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026921 AK076845 AK076845 http://www.ncbi.nlm.nih.gov/nuccore/AK076845 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026922 AK076878 AK076878 http://www.ncbi.nlm.nih.gov/nuccore/AK076878 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026923 AK077428 AK077428 http://www.ncbi.nlm.nih.gov/nuccore/AK077428 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026924 AK078296 AK078296 http://www.ncbi.nlm.nih.gov/nuccore/AK078296 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026925 AK078359 AK078359 http://www.ncbi.nlm.nih.gov/nuccore/AK078359 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026926 AK078978 AK078978 http://www.ncbi.nlm.nih.gov/nuccore/AK078978 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026927 AK078983 AK078983 http://www.ncbi.nlm.nih.gov/nuccore/AK078983 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026928 AK079655 AK079655 http://www.ncbi.nlm.nih.gov/nuccore/AK079655 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026929 AK080153 AK080153 http://www.ncbi.nlm.nih.gov/nuccore/AK080153 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026930 AK080436 AK080436 http://www.ncbi.nlm.nih.gov/nuccore/AK080436 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026931 AK080586 AK080586 http://www.ncbi.nlm.nih.gov/nuccore/AK080586 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026932 AK081070 AK081070 http://www.ncbi.nlm.nih.gov/nuccore/AK081070 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026933 AK081105 AK081105 http://www.ncbi.nlm.nih.gov/nuccore/AK081105 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026934 AK081403 AK081403 http://www.ncbi.nlm.nih.gov/nuccore/AK081403 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026935 AK081423 AK081423 http://www.ncbi.nlm.nih.gov/nuccore/AK081423 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026936 AK082143 AK082143 http://www.ncbi.nlm.nih.gov/nuccore/AK082143 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026937 AK083508 AK083508 http://www.ncbi.nlm.nih.gov/nuccore/AK083508 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026938 AK084036 AK084036 http://www.ncbi.nlm.nih.gov/nuccore/AK084036 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026939 AK084095 AK084095 http://www.ncbi.nlm.nih.gov/nuccore/AK084095 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026940 AK084102 AK084102 http://www.ncbi.nlm.nih.gov/nuccore/AK084102 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026941 AK084115 AK084115 http://www.ncbi.nlm.nih.gov/nuccore/AK084115 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026942 AK084189 AK084189 http://www.ncbi.nlm.nih.gov/nuccore/AK084189 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026943 AK084363 AK084363 http://www.ncbi.nlm.nih.gov/nuccore/AK084363 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026944 AK084753 AK084753 http://www.ncbi.nlm.nih.gov/nuccore/AK084753 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026945 AK084755 AK084755 http://www.ncbi.nlm.nih.gov/nuccore/AK084755 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026946 AK085609 AK085609 http://www.ncbi.nlm.nih.gov/nuccore/AK085609 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026947 AK085783 AK085783 http://www.ncbi.nlm.nih.gov/nuccore/AK085783 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026948 AK085978 AK085978 http://www.ncbi.nlm.nih.gov/nuccore/AK085978 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026949 AK086030 AK086030 http://www.ncbi.nlm.nih.gov/nuccore/AK086030 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026950 AK086184 AK086184 http://www.ncbi.nlm.nih.gov/nuccore/AK086184 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026951 AK086690 AK086690 http://www.ncbi.nlm.nih.gov/nuccore/AK086690 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026952 AK087613 AK087613 http://www.ncbi.nlm.nih.gov/nuccore/AK087613 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026953 AK089491 AK089491 http://www.ncbi.nlm.nih.gov/nuccore/AK089491 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026954 AK089590 AK089590 http://www.ncbi.nlm.nih.gov/nuccore/AK089590 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026955 AK089614 AK089614 http://www.ncbi.nlm.nih.gov/nuccore/AK089614 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026956 AK089617 AK089617 http://www.ncbi.nlm.nih.gov/nuccore/AK089617 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026957 AK089620 AK089620 http://www.ncbi.nlm.nih.gov/nuccore/AK089620 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026958 AK089735 AK089735 http://www.ncbi.nlm.nih.gov/nuccore/AK089735 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026959 AK089776 AK089776 http://www.ncbi.nlm.nih.gov/nuccore/AK089776 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026960 AK089849 AK089849 http://www.ncbi.nlm.nih.gov/nuccore/AK089849 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026961 AK089870 AK089870 http://www.ncbi.nlm.nih.gov/nuccore/AK089870 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026962 AK090205 AK090205 http://www.ncbi.nlm.nih.gov/nuccore/AK090205 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026963 AK090293 AK090293 http://www.ncbi.nlm.nih.gov/nuccore/AK090293 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026964 AK131756 AK131756 http://www.ncbi.nlm.nih.gov/nuccore/AK131756 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026965 AK131878 AK131878 http://www.ncbi.nlm.nih.gov/nuccore/AK131878 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026966 AK132507 AK132507 http://www.ncbi.nlm.nih.gov/nuccore/AK132507 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026967 AK132620 AK132620 http://www.ncbi.nlm.nih.gov/nuccore/AK132620 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026968 AK132818 AK132818 http://www.ncbi.nlm.nih.gov/nuccore/AK132818 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026969 AK132844 AK132844 http://www.ncbi.nlm.nih.gov/nuccore/AK132844 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026970 AK133692 AK133692 http://www.ncbi.nlm.nih.gov/nuccore/AK133692 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026971 AK133765 AK133765 http://www.ncbi.nlm.nih.gov/nuccore/AK133765 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026972 AK133808 AK133808 http://www.ncbi.nlm.nih.gov/nuccore/AK133808 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026973 AK134145 AK134145 http://www.ncbi.nlm.nih.gov/nuccore/AK134145 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026974 AK135459 AK135459 http://www.ncbi.nlm.nih.gov/nuccore/AK135459 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026975 AK135695 AK135695 http://www.ncbi.nlm.nih.gov/nuccore/AK135695 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026976 AK135830 AK135830 http://www.ncbi.nlm.nih.gov/nuccore/AK135830 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026977 AK136392 AK136392 http://www.ncbi.nlm.nih.gov/nuccore/AK136392 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026978 AK136693 AK136693 http://www.ncbi.nlm.nih.gov/nuccore/AK136693 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026979 AK136989 AK136989 http://www.ncbi.nlm.nih.gov/nuccore/AK136989 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026980 AK137670 AK137670 http://www.ncbi.nlm.nih.gov/nuccore/AK137670 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026981 AK138107 AK138107 http://www.ncbi.nlm.nih.gov/nuccore/AK138107 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026982 AK138425 AK138425 http://www.ncbi.nlm.nih.gov/nuccore/AK138425 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026983 AK138551 AK138551 http://www.ncbi.nlm.nih.gov/nuccore/AK138551 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026984 AK138620 AK138620 http://www.ncbi.nlm.nih.gov/nuccore/AK138620 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026985 AK138862 AK138862 http://www.ncbi.nlm.nih.gov/nuccore/AK138862 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026986 AK138914 AK138914 http://www.ncbi.nlm.nih.gov/nuccore/AK138914 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026987 AK139228 AK139228 http://www.ncbi.nlm.nih.gov/nuccore/AK139228 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026988 AK139316 AK139316 http://www.ncbi.nlm.nih.gov/nuccore/AK139316 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026989 AK139755 AK139755 http://www.ncbi.nlm.nih.gov/nuccore/AK139755 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026990 AK139932 AK139932 http://www.ncbi.nlm.nih.gov/nuccore/AK139932 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026991 AK140106 AK140106 http://www.ncbi.nlm.nih.gov/nuccore/AK140106 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026992 AK140518 AK140518 http://www.ncbi.nlm.nih.gov/nuccore/AK140518 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026993 AK140787 AK140787 http://www.ncbi.nlm.nih.gov/nuccore/AK140787 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026994 AK140835 AK140835 http://www.ncbi.nlm.nih.gov/nuccore/AK140835 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026995 AK140883 AK140883 http://www.ncbi.nlm.nih.gov/nuccore/AK140883 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026996 AK140958 AK140958 http://www.ncbi.nlm.nih.gov/nuccore/AK140958 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026997 AK141540 AK141540 http://www.ncbi.nlm.nih.gov/nuccore/AK141540 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026998 AK141628 AK141628 http://www.ncbi.nlm.nih.gov/nuccore/AK141628 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00026999 AK142013 AK142013 http://www.ncbi.nlm.nih.gov/nuccore/AK142013 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027000 AK142410 AK142410 http://www.ncbi.nlm.nih.gov/nuccore/AK142410 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027001 AK142416 AK142416 http://www.ncbi.nlm.nih.gov/nuccore/AK142416 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027002 AK142482 AK142482 http://www.ncbi.nlm.nih.gov/nuccore/AK142482 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027003 AK142778 AK142778 http://www.ncbi.nlm.nih.gov/nuccore/AK142778 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027004 AK142958 AK142958 http://www.ncbi.nlm.nih.gov/nuccore/AK142958 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027005 AK143034 AK143034 http://www.ncbi.nlm.nih.gov/nuccore/AK143034 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027006 AK143146 AK143146 http://www.ncbi.nlm.nih.gov/nuccore/AK143146 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027007 AK144104 AK144104 http://www.ncbi.nlm.nih.gov/nuccore/AK144104 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027008 AK144201 AK144201 http://www.ncbi.nlm.nih.gov/nuccore/AK144201 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027009 AK144914 AK144914 http://www.ncbi.nlm.nih.gov/nuccore/AK144914 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027010 AK149037 AK149037 http://www.ncbi.nlm.nih.gov/nuccore/AK149037 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027011 AK149172 AK149172 http://www.ncbi.nlm.nih.gov/nuccore/AK149172 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027012 AK149691 AK149691 http://www.ncbi.nlm.nih.gov/nuccore/AK149691 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027013 AK150079 AK150079 http://www.ncbi.nlm.nih.gov/nuccore/AK150079 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027014 AK153753 AK153753 http://www.ncbi.nlm.nih.gov/nuccore/AK153753 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027015 AK155780 AK155780 http://www.ncbi.nlm.nih.gov/nuccore/AK155780 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027016 AK156229 AK156229 http://www.ncbi.nlm.nih.gov/nuccore/AK156229 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027017 AK156578 AK156578 http://www.ncbi.nlm.nih.gov/nuccore/AK156578 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027018 AK156672 AK156672 http://www.ncbi.nlm.nih.gov/nuccore/AK156672 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027019 AK156802 AK156802 http://www.ncbi.nlm.nih.gov/nuccore/AK156802 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027020 AK157094 AK157094 http://www.ncbi.nlm.nih.gov/nuccore/AK157094 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027021 AK157185 AK157185 http://www.ncbi.nlm.nih.gov/nuccore/AK157185 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027022 AK157495 AK157495 http://www.ncbi.nlm.nih.gov/nuccore/AK157495 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027023 AK157498 AK157498 http://www.ncbi.nlm.nih.gov/nuccore/AK157498 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027024 AK157530 AK157530 http://www.ncbi.nlm.nih.gov/nuccore/AK157530 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027025 AK157564 AK157564 http://www.ncbi.nlm.nih.gov/nuccore/AK157564 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027026 AK158741 AK158741 http://www.ncbi.nlm.nih.gov/nuccore/AK158741 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027027 AK158887 AK158887 http://www.ncbi.nlm.nih.gov/nuccore/AK158887 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027028 AK162735 AK162735 http://www.ncbi.nlm.nih.gov/nuccore/AK162735 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027029 AK162998 AK162998 http://www.ncbi.nlm.nih.gov/nuccore/AK162998 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027030 AK171827 AK171827 http://www.ncbi.nlm.nih.gov/nuccore/AK171827 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027031 AK180240 AK180240 http://www.ncbi.nlm.nih.gov/nuccore/AK180240 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027032 AK191463 AK191463 http://www.ncbi.nlm.nih.gov/nuccore/AK191463 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027033 AK197782 AK197782 http://www.ncbi.nlm.nih.gov/nuccore/AK197782 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027034 AK212600 AK212600 http://www.ncbi.nlm.nih.gov/nuccore/AK212600 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027035 AK214167 AK214167 http://www.ncbi.nlm.nih.gov/nuccore/AK214167 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027036 AU016662 AU016662 http://www.ncbi.nlm.nih.gov/nuccore/AU016662 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027037 AU019880 AU019880 http://www.ncbi.nlm.nih.gov/nuccore/AU019880 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027038 AU022045 AU022045 http://www.ncbi.nlm.nih.gov/nuccore/AU022045 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027039 AU040911 AU040911 http://www.ncbi.nlm.nih.gov/nuccore/AU040911 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027040 AU042851 AU042851 http://www.ncbi.nlm.nih.gov/nuccore/AU042851 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027041 AV045102 AV045102 http://www.ncbi.nlm.nih.gov/nuccore/AV045102 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027042 AV057789 AV057789 http://www.ncbi.nlm.nih.gov/nuccore/AV057789 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027043 AV110871 AV110871 http://www.ncbi.nlm.nih.gov/nuccore/AV110871 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027044 AV127023 AV127023 http://www.ncbi.nlm.nih.gov/nuccore/AV127023 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027045 AV170241 AV170241 http://www.ncbi.nlm.nih.gov/nuccore/AV170241 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027046 AV213405 AV213405 http://www.ncbi.nlm.nih.gov/nuccore/AV213405 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027047 AV216984 AV216984 http://www.ncbi.nlm.nih.gov/nuccore/AV216984 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027048 AV229195 AV229195 http://www.ncbi.nlm.nih.gov/nuccore/AV229195 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027049 AV271189 AV271189 http://www.ncbi.nlm.nih.gov/nuccore/AV271189 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027050 AV309800 AV309800 http://www.ncbi.nlm.nih.gov/nuccore/AV309800 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027051 AV337624 AV337624 http://www.ncbi.nlm.nih.gov/nuccore/AV337624 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027052 AW121856 AW121856 http://www.ncbi.nlm.nih.gov/nuccore/AW121856 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027053 AW123678 AW123678 http://www.ncbi.nlm.nih.gov/nuccore/AW123678 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027054 AW494074 AW494074 http://www.ncbi.nlm.nih.gov/nuccore/AW494074 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027055 AW495413 AW495413 http://www.ncbi.nlm.nih.gov/nuccore/AW495413 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027056 AW543447 AW543447 http://www.ncbi.nlm.nih.gov/nuccore/AW543447 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027057 AW543705 AW543705 http://www.ncbi.nlm.nih.gov/nuccore/?term=AW543705 mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00027058 AW544672 AW544672 http://www.ncbi.nlm.nih.gov/nuccore/AW544672 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027059 AW553423 AW553423 http://www.ncbi.nlm.nih.gov/nuccore/AW553423 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027060 AW555202 AW555202 http://www.ncbi.nlm.nih.gov/nuccore/AW555202 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027061 AW555368 AW555368 http://www.ncbi.nlm.nih.gov/nuccore/AW555368 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027062 AW556834 AW556834 http://www.ncbi.nlm.nih.gov/nuccore/AW556834 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027063 AW557641 AW557641 http://www.ncbi.nlm.nih.gov/nuccore/AW557641 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027064 AW558862 AW558862 http://www.ncbi.nlm.nih.gov/nuccore/AW558862 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027065 AW909306 AW909306 http://www.ncbi.nlm.nih.gov/nuccore/AW909306 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027066 AY178855 AY178855 http://www.ncbi.nlm.nih.gov/nuccore/AY178855 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027067 BB012661 BB012661 http://www.ncbi.nlm.nih.gov/nuccore/BB012661 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027068 BB016866 BB016866 http://www.ncbi.nlm.nih.gov/nuccore/BB016866 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027069 BB017018 BB017018 http://www.ncbi.nlm.nih.gov/nuccore/BB017018 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027070 BB043897 BB043897 http://www.ncbi.nlm.nih.gov/nuccore/BB043897 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027071 BB051562 BB051562 http://www.ncbi.nlm.nih.gov/nuccore/BB051562 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027072 BB080140 BB080140 http://www.ncbi.nlm.nih.gov/nuccore/BB080140 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027073 BB085906 BB085906 http://www.ncbi.nlm.nih.gov/nuccore/BB085906 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027074 BB097040 BB097040 http://www.ncbi.nlm.nih.gov/nuccore/BB097040 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027075 BB099980 BB099980 http://www.ncbi.nlm.nih.gov/nuccore/BB099980 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027076 BB117670 BB117670 http://www.ncbi.nlm.nih.gov/nuccore/BB117670 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027077 BB121580 BB121580 http://www.ncbi.nlm.nih.gov/nuccore/BB121580 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027078 BB158810 BB158810 http://www.ncbi.nlm.nih.gov/nuccore/BB158810 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027079 BB183984 BB183984 http://www.ncbi.nlm.nih.gov/nuccore/BB183984 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027080 BB193921 BB193921 http://www.ncbi.nlm.nih.gov/nuccore/BB193921 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027081 BB195788 BB195788 http://www.ncbi.nlm.nih.gov/nuccore/BB195788 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027082 BB205199 BB205199 http://www.ncbi.nlm.nih.gov/nuccore/BB205199 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027083 BB223643 BB223643 http://www.ncbi.nlm.nih.gov/nuccore/BB223643 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027084 BB241135 BB241135 http://www.ncbi.nlm.nih.gov/nuccore/BB241135 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027085 BB255841 BB255841 http://www.ncbi.nlm.nih.gov/nuccore/BB255841 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027086 BB273287 BB273287 http://www.ncbi.nlm.nih.gov/nuccore/BB273287 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027087 BB276575 BB276575 http://www.ncbi.nlm.nih.gov/nuccore/BB276575 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027088 BB315798 BB315798 http://www.ncbi.nlm.nih.gov/nuccore/BB315798 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027089 BB335101 BB335101 http://www.ncbi.nlm.nih.gov/nuccore/BB335101 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027090 BB344838 BB344838 http://www.ncbi.nlm.nih.gov/nuccore/BB344838 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027091 BB345991 BB345991 http://www.ncbi.nlm.nih.gov/nuccore/BB345991 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027092 BB359521 BB359521 http://www.ncbi.nlm.nih.gov/nuccore/BB359521 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027093 BB381966 BB381966 http://www.ncbi.nlm.nih.gov/nuccore/?term=BB381966 mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00027094 BB393078 BB393078 http://www.ncbi.nlm.nih.gov/nuccore/BB393078 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027095 BB470306 BB470306 http://www.ncbi.nlm.nih.gov/nuccore/BB470306 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027096 BB473929 BB473929 http://www.ncbi.nlm.nih.gov/nuccore/BB473929 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027097 BB496295 BB496295 http://www.ncbi.nlm.nih.gov/nuccore/BB496295 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027098 BB521034 BB521034 http://www.ncbi.nlm.nih.gov/nuccore/BB521034 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027099 BB529352 BB529352 http://www.ncbi.nlm.nih.gov/nuccore/BB529352 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027100 BB662083 BB662083 http://www.ncbi.nlm.nih.gov/nuccore/BB662083 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027101 BB703378 BB703378 http://www.ncbi.nlm.nih.gov/nuccore/BB703378 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027102 BB709387 BB709387 http://www.ncbi.nlm.nih.gov/nuccore/BB709387 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027103 BB710064 BB710064 http://www.ncbi.nlm.nih.gov/nuccore/BB710064 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027104 BB712583 BB712583 http://www.ncbi.nlm.nih.gov/nuccore/BB712583 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027105 BB713391 BB713391 http://www.ncbi.nlm.nih.gov/nuccore/BB713391 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027106 BB728372 BB728372 http://www.ncbi.nlm.nih.gov/nuccore/BB728372 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027107 BB735036 BB735036 http://www.ncbi.nlm.nih.gov/nuccore/BB735036 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027108 BB754142 BB754142 http://www.ncbi.nlm.nih.gov/nuccore/BB754142 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027109 BB763701 BB763701 http://www.ncbi.nlm.nih.gov/nuccore/BB763701 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027110 BB767243 BB767243 http://www.ncbi.nlm.nih.gov/nuccore/BB767243 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027111 BB794742 BB794742 http://www.ncbi.nlm.nih.gov/nuccore/BB794742 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027112 BB829165 BB829165 http://www.ncbi.nlm.nih.gov/nuccore/BB829165 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027113 BC003764 BC003764 http://www.ncbi.nlm.nih.gov/nuccore/?term=BC003764 mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00027114 BC018588 BC018588 http://www.ncbi.nlm.nih.gov/nuccore/BC018588 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027115 BC021831 BC021831 http://www.ncbi.nlm.nih.gov/nuccore/BC021831 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027116 BC024416 BC024416 http://www.ncbi.nlm.nih.gov/nuccore/BC024416 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027117 BC029124 BC029124 http://www.ncbi.nlm.nih.gov/nuccore/BC029124 lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027118 BC030004 BC030004 http://www.ncbi.nlm.nih.gov/nuccore/BC030004 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027119 BC035532 BC035532 http://www.ncbi.nlm.nih.gov/nuccore/BC035532 lncRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027120 BC035679 BC035679 http://www.ncbi.nlm.nih.gov/nuccore/BC035679 lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027121 BC038538 BC038538 http://www.ncbi.nlm.nih.gov/nuccore/BC038538 lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027122 BC038887 BC038887 http://www.ncbi.nlm.nih.gov/nuccore/BC038887 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027123 BC055052 BC055052 http://www.ncbi.nlm.nih.gov/nuccore/BC055052 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027124 BC058854 BC058854 http://www.ncbi.nlm.nih.gov/nuccore/BC058854 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027125 BC065566 BC065566 http://www.ncbi.nlm.nih.gov/nuccore/BC065566 lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027126 BC067836 BC067836 http://www.ncbi.nlm.nih.gov/nuccore/BC067836 lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027127 BC071254 BC071254 http://www.ncbi.nlm.nih.gov/nuccore/BC071254 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027128 BC075654 BC075654 http://www.ncbi.nlm.nih.gov/nuccore/BC075654 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027129 BC127080 BC127080 http://www.ncbi.nlm.nih.gov/nuccore/BC127080 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00027130 BE628832 BE628832 http://www.ncbi.nlm.nih.gov/nuccore/BE628832 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027131 BE650311 BE650311 http://www.ncbi.nlm.nih.gov/nuccore/BE650311 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027132 BE945748 BE945748 http://www.ncbi.nlm.nih.gov/nuccore/BE945748 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027133 BE948370 BE948370 http://www.ncbi.nlm.nih.gov/nuccore/BE948370 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027134 BE951647 BE951647 http://www.ncbi.nlm.nih.gov/nuccore/BE951647 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027135 BE987947 BE987947 http://www.ncbi.nlm.nih.gov/nuccore/BE987947 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027136 BE992875 BE992875 http://www.ncbi.nlm.nih.gov/nuccore/BE992875 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027137 BF148780 BF148780 http://www.ncbi.nlm.nih.gov/nuccore/BF148780 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027138 BF166000 BF166000 http://www.ncbi.nlm.nih.gov/nuccore/BF166000 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027139 BF227338 BF227338 http://www.ncbi.nlm.nih.gov/nuccore/BF227338 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027140 BF321332 BF321332 http://www.ncbi.nlm.nih.gov/nuccore/BF321332 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027141 BF455409 BF455409 http://www.ncbi.nlm.nih.gov/nuccore/BF455409 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027142 BF730541 BF730541 http://www.ncbi.nlm.nih.gov/nuccore/BF730541 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027143 BG063240 BG063240 http://www.ncbi.nlm.nih.gov/nuccore/BG063240 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027144 BG065705 BG065705 http://www.ncbi.nlm.nih.gov/nuccore/BG065705 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027145 BG066175 BG066175 http://www.ncbi.nlm.nih.gov/nuccore/BG066175 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027146 BG066346 BG066346 http://www.ncbi.nlm.nih.gov/nuccore/BG066346 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027147 BG066533 BG066533 http://www.ncbi.nlm.nih.gov/nuccore/BG066533 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027148 BG066727 BG066727 http://www.ncbi.nlm.nih.gov/nuccore/BG066727 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027149 BG066746 BG066746 http://www.ncbi.nlm.nih.gov/nuccore/BG066746 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027150 BG066901 BG066901 http://www.ncbi.nlm.nih.gov/nuccore/BG066901 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027151 BG067289 BG067289 http://www.ncbi.nlm.nih.gov/nuccore/BG067289 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027152 BG067993 BG067993 http://www.ncbi.nlm.nih.gov/nuccore/BG067993 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027153 BG068123 BG068123 http://www.ncbi.nlm.nih.gov/nuccore/BG068123 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027154 BG068591 BG068591 http://www.ncbi.nlm.nih.gov/nuccore/BG068591 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027155 BG068672 BG068672 http://www.ncbi.nlm.nih.gov/nuccore/BG068672 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027156 BG068681 BG068681 http://www.ncbi.nlm.nih.gov/nuccore/BG068681 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027157 BG068807 BG068807 http://www.ncbi.nlm.nih.gov/nuccore/BG068807 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027158 BG068932 BG068932 http://www.ncbi.nlm.nih.gov/nuccore/BG068932 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027159 BG068986 BG068986 http://www.ncbi.nlm.nih.gov/nuccore/BG068986 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027160 BG068989 BG068989 http://www.ncbi.nlm.nih.gov/nuccore/BG068989 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027161 BG069080 BG069080 http://www.ncbi.nlm.nih.gov/nuccore/BG069080 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027162 BG069109 BG069109 http://www.ncbi.nlm.nih.gov/nuccore/BG069109 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027163 BG069648 BG069648 http://www.ncbi.nlm.nih.gov/nuccore/BG069648 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027164 BG069857 BG069857 http://www.ncbi.nlm.nih.gov/nuccore/BG069857 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027165 BG069991 BG069991 http://www.ncbi.nlm.nih.gov/nuccore/BG069991 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027166 BG070566 BG070566 http://www.ncbi.nlm.nih.gov/nuccore/BG070566 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027167 BG070611 BG070611 http://www.ncbi.nlm.nih.gov/nuccore/BG070611 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027168 BG070655 BG070655 http://www.ncbi.nlm.nih.gov/nuccore/BG070655 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027169 BG070910 BG070910 http://www.ncbi.nlm.nih.gov/nuccore/BG070910 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027170 BG071002 BG071002 http://www.ncbi.nlm.nih.gov/nuccore/BG071002 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027171 BG071600 BG071600 http://www.ncbi.nlm.nih.gov/nuccore/BG071600 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027172 BG072319 BG072319 http://www.ncbi.nlm.nih.gov/nuccore/BG072319 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027173 BG073432 BG073432 http://www.ncbi.nlm.nih.gov/nuccore/BG073432 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027174 BG073921 BG073921 http://www.ncbi.nlm.nih.gov/nuccore/BG073921 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027175 BG074150 BG074150 http://www.ncbi.nlm.nih.gov/nuccore/BG074150 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027176 BG074624 BG074624 http://www.ncbi.nlm.nih.gov/nuccore/BG074624 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027177 BG074662 BG074662 http://www.ncbi.nlm.nih.gov/nuccore/BG074662 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027178 BG075370 BG075370 http://www.ncbi.nlm.nih.gov/nuccore/BG075370 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027179 BG076014 BG076014 http://www.ncbi.nlm.nih.gov/nuccore/BG076014 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027180 BG076325 BG076325 http://www.ncbi.nlm.nih.gov/nuccore/BG076325 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027181 BG078857 BG078857 http://www.ncbi.nlm.nih.gov/nuccore/BG078857 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027182 BG083020 BG083020 http://www.ncbi.nlm.nih.gov/nuccore/BG083020 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027183 BG083989 BG083989 http://www.ncbi.nlm.nih.gov/nuccore/BG083989 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027184 BG141806 BG141806 http://www.ncbi.nlm.nih.gov/nuccore/BG141806 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027185 BG297038 1300007C21Rik http://www.ncbi.nlm.nih.gov/nuccore/BG297038 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027186 BG796845 BG796845 http://www.ncbi.nlm.nih.gov/nuccore/?term=BG796845 mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00027187 BG963792 BG963792 http://www.ncbi.nlm.nih.gov/nuccore/BG963792 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027188 BG966742 BG966742 http://www.ncbi.nlm.nih.gov/nuccore/BG966742 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027189 BG976607 BG976607 http://www.ncbi.nlm.nih.gov/nuccore/BG976607 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027190 BI076698 BI076698 http://www.ncbi.nlm.nih.gov/nuccore/BI076698 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027191 BI076708 BI076708 http://www.ncbi.nlm.nih.gov/nuccore/BI076708 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027192 BI076711 BI076711 http://www.ncbi.nlm.nih.gov/nuccore/BI076711 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027193 BI076834 BI076834 http://www.ncbi.nlm.nih.gov/nuccore/BI076834 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027194 BI499978 BI499978 http://www.ncbi.nlm.nih.gov/nuccore/BI499978 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027195 BI651113 BI651113 http://www.ncbi.nlm.nih.gov/nuccore/BI651113 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027196 BI736050 BI736050 http://www.ncbi.nlm.nih.gov/nuccore/BI736050 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027197 BI963564 BI963564 http://www.ncbi.nlm.nih.gov/nuccore/BI963564 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027198 BJ625728 BJ625728 http://www.ncbi.nlm.nih.gov/nuccore/?term=BJ625728 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00027199 BM115860 BM115860 http://www.ncbi.nlm.nih.gov/nuccore/BM115860 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027200 BM117404 BM117404 http://www.ncbi.nlm.nih.gov/nuccore/BM117404 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027201 BM117570 BM117570 http://www.ncbi.nlm.nih.gov/nuccore/BM117570 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027202 BM195235 BM195235 http://www.ncbi.nlm.nih.gov/nuccore/BM195235 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027203 BM198753 BM198753 http://www.ncbi.nlm.nih.gov/nuccore/BM198753 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027204 BM213788 BM213788 http://www.ncbi.nlm.nih.gov/nuccore/BM213788 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027205 BM222792 BM222792 http://www.ncbi.nlm.nih.gov/nuccore/?term=BM222792 mRNA Mus musculus 18451862 Pseudopodium Migrating cell qRT-PCR About 50 RNAs were significantly enriched in pseudopodia in response to both migratory stimuli (table 1 and S1). Data are collected from Table 1 and S1. RLID00027206 BM225255 BM225255 http://www.ncbi.nlm.nih.gov/nuccore/BM225255 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027207 BM232203 BM232203 http://www.ncbi.nlm.nih.gov/nuccore/BM232203 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027208 BM239430 4833416J08Rik http://www.ncbi.nlm.nih.gov/nuccore/BM239430 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027209 BM241271 BM241271 http://www.ncbi.nlm.nih.gov/nuccore/BM241271 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027210 BM247957 BM247957 http://www.ncbi.nlm.nih.gov/nuccore/BM247957 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027211 BQ176181 BQ176181 http://www.ncbi.nlm.nih.gov/nuccore/BQ176181 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027212 BX647987 BX647987 http://www.ncbi.nlm.nih.gov/nuccore/BX647987 lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027213 BX772720 BX772720 http://www.ncbi.nlm.nih.gov/nuccore/?term=BX772720 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00027214 C77540 C77540 http://www.ncbi.nlm.nih.gov/nuccore/C77540 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027215 C79035 C79035 http://www.ncbi.nlm.nih.gov/nuccore/C79035 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027216 C79752 C79752 http://www.ncbi.nlm.nih.gov/nuccore/C79752 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027217 C81225 C81225 http://www.ncbi.nlm.nih.gov/nuccore/C81225 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027218 C86506 C86506 http://www.ncbi.nlm.nih.gov/nuccore/C86506 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027219 CA971768 CA971768 http://www.ncbi.nlm.nih.gov/nuccore/?term=CA971768 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00027220 DQ359732 DQ359732 http://www.ncbi.nlm.nih.gov/nuccore/?term=DQ359732 mRNA Spisula solidissima 22356233 Centrosome Oocyte RT-PCR "TABLE 1: Similarity between centrosome-associated RNAs and viral sequences (from ref. [32], with modifications). Data are collected from Table 1. " RLID00027221 DQ539895 piR-7 http://www.ncbi.nlm.nih.gov/nuccore/DQ539895 piRNA Mus musculus 18204908 Nucleolus Sertoli cell In situ hybridization|Northern blot|Microarray "FISH analysis of piRNA localization revealed a strong signal in the nucleolus of Sertoli cells, in agreement with our observed miRNA pattern. The images of the two piRNAs shown in Figure 6S are essentially identical to all piRNAs tested. This nucleolar localization was abolished in MIWI-null testis (Figure 6C; Sertoli cell, insert, yellow arrow). The effect of MIWI deletion is surprising since expression of MIWI protein was reported in the cytoplasm of spermatocytes and spermatids but not Sertoli cells (Deng & Lin 2002, Kotaja et al. 2006). It is possible that the greater levels of expression in spermatocytes and spermatids have obscured visual- ization of MIWI staining in the Sertoli cells where MIWI could be responsible for localization of piRNAs to the nucleolus and possibly their processing. In meiotic spreads, only piR-7 and piR-17005 showed strong localization to the dense body, chromosome cores and possibly telomeres, while the other three (piR-17037, 17043, 17080) showed very weak or no association (Figure 6D). MIWI deletion did not affect piRNAs localization in the meiotic nucleus. " RLID00027222 DQ548893 piR-17005 http://www.ncbi.nlm.nih.gov/nuccore/DQ548893 piRNA Mus musculus 18204908 Nucleolus Sertoli cell In situ hybridization|Northern blot|Microarray "FISH analysis of piRNA localization revealed a strong signal in the nucleolus of Sertoli cells, in agreement with our observed miRNA pattern. The images of the two piRNAs shown in Figure 6S are essentially identical to all piRNAs tested. This nucleolar localization was abolished in MIWI-null testis (Figure 6C; Sertoli cell, insert, yellow arrow). The effect of MIWI deletion is surprising since expression of MIWI protein was reported in the cytoplasm of spermatocytes and spermatids but not Sertoli cells (Deng & Lin 2002, Kotaja et al. 2006). It is possible that the greater levels of expression in spermatocytes and spermatids have obscured visual- ization of MIWI staining in the Sertoli cells where MIWI could be responsible for localization of piRNAs to the nucleolus and possibly their processing. In meiotic spreads, only piR-7 and piR-17005 showed strong localization to the dense body, chromosome cores and possibly telomeres, while the other three (piR-17037, 17043, 17080) showed very weak or no association (Figure 6D). MIWI deletion did not affect piRNAs localization in the meiotic nucleus. " RLID00027223 DQ548925 piR-17037 http://www.ncbi.nlm.nih.gov/nuccore/DQ548925 piRNA Mus musculus 18204908 Nucleolus Sertoli cell In situ hybridization|Northern blot|Microarray "FISH analysis of piRNA localization revealed a strong signal in the nucleolus of Sertoli cells, in agreement with our observed miRNA pattern. The images of the two piRNAs shown in Figure 6S are essentially identical to all piRNAs tested. This nucleolar localization was abolished in MIWI-null testis (Figure 6C; Sertoli cell, insert, yellow arrow). The effect of MIWI deletion is surprising since expression of MIWI protein was reported in the cytoplasm of spermatocytes and spermatids but not Sertoli cells (Deng & Lin 2002, Kotaja et al. 2006). It is possible that the greater levels of expression in spermatocytes and spermatids have obscured visual- ization of MIWI staining in the Sertoli cells where MIWI could be responsible for localization of piRNAs to the nucleolus and possibly their processing. In meiotic spreads, only piR-7 and piR-17005 showed strong localization to the dense body, chromosome cores and possibly telomeres, while the other three (piR-17037, 17043, 17080) showed very weak or no association (Figure 6D). MIWI deletion did not affect piRNAs localization in the meiotic nucleus. " RLID00027224 DQ548931 piR-17043 http://www.ncbi.nlm.nih.gov/nuccore/DQ548931 piRNA Mus musculus 18204908 Nucleolus Sertoli cell In situ hybridization|Northern blot|Microarray "FISH analysis of piRNA localization revealed a strong signal in the nucleolus of Sertoli cells, in agreement with our observed miRNA pattern. The images of the two piRNAs shown in Figure 6S are essentially identical to all piRNAs tested. This nucleolar localization was abolished in MIWI-null testis (Figure 6C; Sertoli cell, insert, yellow arrow). The effect of MIWI deletion is surprising since expression of MIWI protein was reported in the cytoplasm of spermatocytes and spermatids but not Sertoli cells (Deng & Lin 2002, Kotaja et al. 2006). It is possible that the greater levels of expression in spermatocytes and spermatids have obscured visual- ization of MIWI staining in the Sertoli cells where MIWI could be responsible for localization of piRNAs to the nucleolus and possibly their processing. In meiotic spreads, only piR-7 and piR-17005 showed strong localization to the dense body, chromosome cores and possibly telomeres, while the other three (piR-17037, 17043, 17080) showed very weak or no association (Figure 6D). MIWI deletion did not affect piRNAs localization in the meiotic nucleus. " RLID00027225 DQ548968 piR-17080 http://www.ncbi.nlm.nih.gov/nuccore/DQ548968 piRNA Mus musculus 18204908 Nucleolus Sertoli cell In situ hybridization|Northern blot|Microarray "FISH analysis of piRNA localization revealed a strong signal in the nucleolus of Sertoli cells, in agreement with our observed miRNA pattern. The images of the two piRNAs shown in Figure 6S are essentially identical to all piRNAs tested. This nucleolar localization was abolished in MIWI-null testis (Figure 6C; Sertoli cell, insert, yellow arrow). The effect of MIWI deletion is surprising since expression of MIWI protein was reported in the cytoplasm of spermatocytes and spermatids but not Sertoli cells (Deng & Lin 2002, Kotaja et al. 2006). It is possible that the greater levels of expression in spermatocytes and spermatids have obscured visual- ization of MIWI staining in the Sertoli cells where MIWI could be responsible for localization of piRNAs to the nucleolus and possibly their processing. In meiotic spreads, only piR-7 and piR-17005 showed strong localization to the dense body, chromosome cores and possibly telomeres, while the other three (piR-17037, 17043, 17080) showed very weak or no association (Figure 6D). MIWI deletion did not affect piRNAs localization in the meiotic nucleus. " RLID00027226 DQ571378 piR-31490 http://www.ncbi.nlm.nih.gov/nuccore/DQ571378 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027227 DQ571524 piR-31636 http://www.ncbi.nlm.nih.gov/nuccore/DQ571524 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027228 DQ571525 piR-31637 http://www.ncbi.nlm.nih.gov/nuccore/DQ571525 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027229 DQ571526 piR-31638 http://www.ncbi.nlm.nih.gov/nuccore/DQ571526 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027230 DQ571874 piR-31986 http://www.ncbi.nlm.nih.gov/nuccore/DQ571874 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027231 DQ571875 piR-31987 http://www.ncbi.nlm.nih.gov/nuccore/DQ571875 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027232 DQ579193 piR-47305 http://www.ncbi.nlm.nih.gov/nuccore/DQ579193 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027233 DQ582036 piR-32148 http://www.ncbi.nlm.nih.gov/nuccore/DQ582036 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027234 DQ582264 piR-32376 http://www.ncbi.nlm.nih.gov/nuccore/DQ582264 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027235 DQ582459 piR-32571 http://www.ncbi.nlm.nih.gov/nuccore/DQ582459 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027236 DQ582567 piR-32679 http://www.ncbi.nlm.nih.gov/nuccore/DQ582567 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027237 DQ584697 piR-51809 http://www.ncbi.nlm.nih.gov/nuccore/DQ584697 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027238 DQ584698 piR-51810 http://www.ncbi.nlm.nih.gov/nuccore/DQ584698 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027239 DQ590013 piR-57125 http://www.ncbi.nlm.nih.gov/nuccore/DQ590013 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027240 DQ590407 piR-57519 http://www.ncbi.nlm.nih.gov/nuccore/DQ590407 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027241 DQ591357 piR-58469 http://www.ncbi.nlm.nih.gov/nuccore/DQ591357 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027242 DQ592931 piR-33043 http://www.ncbi.nlm.nih.gov/nuccore/DQ592931 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027243 DQ593039 piR-33151 http://www.ncbi.nlm.nih.gov/nuccore/DQ593039 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027244 DQ593292 piR-33404 http://www.ncbi.nlm.nih.gov/nuccore/DQ593292 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027245 DQ593325 piR-33437 http://www.ncbi.nlm.nih.gov/nuccore/DQ593325 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027246 DQ593671 piR-33783 http://www.ncbi.nlm.nih.gov/nuccore/DQ593671 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027247 DQ594453 piR-60565 http://www.ncbi.nlm.nih.gov/nuccore/DQ594453 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027248 DQ594465 piR-60577 http://www.ncbi.nlm.nih.gov/nuccore/DQ594465 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027249 DQ595535 piR-61647 http://www.ncbi.nlm.nih.gov/nuccore/DQ595535 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027250 DQ595539 piR-61651 http://www.ncbi.nlm.nih.gov/nuccore/DQ595539 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027251 DQ596276 piR-34342 http://www.ncbi.nlm.nih.gov/nuccore/DQ596276 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027252 DQ596468 piR-34534 http://www.ncbi.nlm.nih.gov/nuccore/DQ596468 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027253 DQ596469 piR-34535 http://www.ncbi.nlm.nih.gov/nuccore/DQ596469 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027254 DQ596470 piR-34536 http://www.ncbi.nlm.nih.gov/nuccore/DQ596470 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027255 DQ596738 piR-34804 http://www.ncbi.nlm.nih.gov/nuccore/DQ596738 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027256 DQ596805 piR-34871 http://www.ncbi.nlm.nih.gov/nuccore/DQ596805 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027257 DQ597155 piR-35221 http://www.ncbi.nlm.nih.gov/nuccore/DQ597155 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027258 DQ597347 piR-35413 http://www.ncbi.nlm.nih.gov/nuccore/DQ597347 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027259 DQ597403 piR-35469 http://www.ncbi.nlm.nih.gov/nuccore/DQ597403 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027260 DQ597482 piR-35548 http://www.ncbi.nlm.nih.gov/nuccore/DQ597482 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027261 DQ597483 piR-35549 http://www.ncbi.nlm.nih.gov/nuccore/DQ597483 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027262 DQ597484 piR-35550 http://www.ncbi.nlm.nih.gov/nuccore/DQ597484 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027263 DQ597975 piR-36041 http://www.ncbi.nlm.nih.gov/nuccore/DQ597975 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027264 DQ597990 piR-36056 http://www.ncbi.nlm.nih.gov/nuccore/DQ597990 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027265 DQ597997 piR-36063 http://www.ncbi.nlm.nih.gov/nuccore/DQ597997 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027266 DQ598159 piR-36225 http://www.ncbi.nlm.nih.gov/nuccore/DQ598159 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027267 DQ598167 piR-36233 http://www.ncbi.nlm.nih.gov/nuccore/DQ598167 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027268 DQ598175 piR-36241 http://www.ncbi.nlm.nih.gov/nuccore/DQ598175 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027269 DQ598263 piR-36329 http://www.ncbi.nlm.nih.gov/nuccore/DQ598263 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027270 DQ598375 piR-36441 http://www.ncbi.nlm.nih.gov/nuccore/DQ598375 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027271 DQ598641 piR-36707 http://www.ncbi.nlm.nih.gov/nuccore/DQ598641 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027272 DQ598675 piR-36741 http://www.ncbi.nlm.nih.gov/nuccore/DQ598675 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027273 DQ598677 piR-36743 http://www.ncbi.nlm.nih.gov/nuccore/DQ598677 piRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027274 DQ600436 piR-38502 http://www.ncbi.nlm.nih.gov/nuccore/DQ600436 piRNA Homo sapiens 24602614 Mitochondrion Hela cell|HEK293 cell Next-generation sequencing "Fig. 1:Mitochondrial genomic location of the 29 piRNAs. The panel has two tracks: the 29-piRNAs (upper track) and mtDNA annotations (lower track). The piRNAs are located throughout mitochondrial genome, including rRNA regions, tRNA regions, and protein-coding regions. Data are collected from Figure 1. " RLID00027275 DQ869571 DQ869571 http://www.ncbi.nlm.nih.gov/nuccore/?term=DQ869571 CheFz1 mRNA mRNA Clytia hemisphaerica 17355179 Cytoplasm Eggs|Embryo|Planula larvae In situ hybridization "In situ hybridisation of C. hemisphaerica eggs, embryos, and planula larvae (fixed at 1 and 3 d after fertilisation), showing the concentration of CheFz1 RNA (top row) in the animal cytoplasm of the egg and around the nuclei during first cleavage, and its graded oral-aboral distribution in blastula and early gastrula stages. " RLID00027276 DQ869572 DQ869572 http://www.ncbi.nlm.nih.gov/nuccore/?term=DQ869572 CheFz3 RNA mRNA Clytia hemisphaerica 17355179 Vegetal Eggs|Embryo|Planula larvae In situ hybridization "CheFz3, whose RNA is localised at the egg vegetal cortex, was found to oppose CheFz1 function and to define an aboral territory. " RLID00027277 DY566077 DY566077 http://www.ncbi.nlm.nih.gov/nuccore/?term=DY566077 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00027278 EB732697 EB732697 http://www.ncbi.nlm.nih.gov/nuccore/?term=EB732697 mRNA Xenopus laevis 26337391 Vegetal Oocyte In situ hybridization FIGURE 1: Identification of novel vegetally localizing RNAs in X. laevis oocytes. Data are collected from Figure 1. RLID00027279 EF565083 lncRNA_ES2 http://www.ncbi.nlm.nih.gov/nuccore/EF565083 lncRNA Homo sapiens 22193719 Nucleus Embryonic stem cell qRT-PCR|Microarray "By means of RNA fractionation followed by quantitative PCR (qPCR), we found that lncRNA_ES1, lncRNA_ES2 and lncRNA_ES3 were preferentially retained in the nucleus (Figure 5A). " RLID00027280 ENSG00000194297 RNU1-75P http://asia.ensembl.org/id/ENSG00000194297 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027281 ENSG00000199308 RNU6-222P http://asia.ensembl.org/id/ENSG00000199308 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027282 ENSG00000199313 RNU4-82P http://asia.ensembl.org/id/ENSG00000199313 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027283 ENSG00000199325 RNU4-39P http://asia.ensembl.org/id/ENSG00000199325 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027284 ENSG00000199488 RNU1-70P http://asia.ensembl.org/id/ENSG00000199488 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027285 ENSG00000199562 RNU6-37P http://asia.ensembl.org/id/ENSG00000199562 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027286 ENSG00000199664 RNU6-1266P http://asia.ensembl.org/id/ENSG00000199664 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027287 ENSG00000199695 RNU6-1128P http://asia.ensembl.org/id/ENSG00000199695 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027288 ENSG00000199709 RNU4-23P http://asia.ensembl.org/id/ENSG00000199709 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027289 ENSG00000199731 RNU6-1079P http://asia.ensembl.org/id/ENSG00000199731 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027290 ENSG00000199805 RNU1-134P http://asia.ensembl.org/id/ENSG00000199805 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027291 ENSG00000199812 RNU6-428P http://asia.ensembl.org/id/ENSG00000199812 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027292 ENSG00000200026 U8 http://asia.ensembl.org/id/ENSG00000200026 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027293 ENSG00000200062 RNU4-58P http://asia.ensembl.org/id/ENSG00000200062 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027294 ENSG00000200107 RNU6-1249P http://asia.ensembl.org/id/ENSG00000200107 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027295 ENSG00000200183 RNU6-238P http://asia.ensembl.org/id/ENSG00000200183 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027296 ENSG00000200296 RNU1-83P http://asia.ensembl.org/id/ENSG00000200296 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027297 ENSG00000200496 U8 http://asia.ensembl.org/id/ENSG00000200496 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027298 ENSG00000200597 RNU1-87P http://asia.ensembl.org/id/ENSG00000200597 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027299 ENSG00000200728 RNU6-271P http://asia.ensembl.org/id/ENSG00000200728 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027300 ENSG00000200731 RNU1-124P http://asia.ensembl.org/id/ENSG00000200731 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027301 ENSG00000200779 RNU6-105P http://asia.ensembl.org/id/ENSG00000200779 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027302 ENSG00000200889 RNU4-13P http://asia.ensembl.org/id/ENSG00000200889 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027303 ENSG00000200903 RNU1-42P http://asia.ensembl.org/id/ENSG00000200903 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027304 ENSG00000200972 RNU5A-8P http://asia.ensembl.org/id/ENSG00000200972 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027305 ENSG00000200975 RNU1-7P http://asia.ensembl.org/id/ENSG00000200975 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027306 ENSG00000201104 RNU6-11P http://asia.ensembl.org/id/ENSG00000201104 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027307 ENSG00000201180 RNU6-115P http://asia.ensembl.org/id/ENSG00000201180 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027308 ENSG00000201223 RNU6-1305P http://asia.ensembl.org/id/ENSG00000201223 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027309 ENSG00000201291 RNU1-34P http://asia.ensembl.org/id/ENSG00000201291 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027310 ENSG00000201317 RNU4-59P http://asia.ensembl.org/id/ENSG00000201317 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027311 ENSG00000201372 RNU6-1251P http://asia.ensembl.org/id/ENSG00000201372 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027312 ENSG00000201388 SNORA68 http://asia.ensembl.org/id/ENSG00000201388 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027313 ENSG00000201441 RNU6-646P http://asia.ensembl.org/id/ENSG00000201441 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027314 ENSG00000201458 RNU4-4P http://asia.ensembl.org/id/ENSG00000201458 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027315 ENSG00000201474 RNU6-164P http://asia.ensembl.org/id/ENSG00000201474 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027316 ENSG00000201517 RNU6-707P http://asia.ensembl.org/id/ENSG00000201517 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027317 ENSG00000201614 RNU4-19P http://asia.ensembl.org/id/ENSG00000201614 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027318 ENSG00000201616 RNU1-91P http://asia.ensembl.org/id/ENSG00000201616 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027319 ENSG00000201648 RNU4-91P http://asia.ensembl.org/id/ENSG00000201648 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027320 ENSG00000201852 RNU6-702P http://asia.ensembl.org/id/ENSG00000201852 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027321 ENSG00000201910 RNU1-140P http://asia.ensembl.org/id/ENSG00000201910 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027322 ENSG00000201922 RNU1-43P http://asia.ensembl.org/id/ENSG00000201922 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027323 ENSG00000202199 RNU1-115P http://asia.ensembl.org/id/ENSG00000202199 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027324 ENSG00000202300 RNU6-487P http://asia.ensembl.org/id/ENSG00000202300 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027325 ENSG00000202313 RNU1-64P http://asia.ensembl.org/id/ENSG00000202313 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027326 ENSG00000202317 RNU1-84P http://asia.ensembl.org/id/ENSG00000202317 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027327 ENSG00000202380 RNU1-55P http://asia.ensembl.org/id/ENSG00000202380 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027328 ENSG00000202534 RNU6-1329P http://asia.ensembl.org/id/ENSG00000202534 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027329 ENSG00000206593 RNU6-47P http://asia.ensembl.org/id/ENSG00000206593 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027330 ENSG00000206599 RNU6-841P http://asia.ensembl.org/id/ENSG00000206599 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027331 ENSG00000206600 RNU6-25P http://asia.ensembl.org/id/ENSG00000206600 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027332 ENSG00000206601 RNU6-431P http://asia.ensembl.org/id/ENSG00000206601 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027333 ENSG00000206629 RNU1-63P http://asia.ensembl.org/id/ENSG00000206629 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027334 ENSG00000206675 RNU6-32P http://asia.ensembl.org/id/ENSG00000206675 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027335 ENSG00000206744 RNU6-620P http://asia.ensembl.org/id/ENSG00000206744 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027336 ENSG00000206772 RNU6-44P http://asia.ensembl.org/id/ENSG00000206772 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027337 ENSG00000206820 RNU1-138P http://asia.ensembl.org/id/ENSG00000206820 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027338 ENSG00000206833 RNU6-20P http://asia.ensembl.org/id/ENSG00000206833 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027339 ENSG00000206875 RNU6-761P http://asia.ensembl.org/id/ENSG00000206875 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027340 ENSG00000206900 RNU6-98P http://asia.ensembl.org/id/ENSG00000206900 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027341 ENSG00000206908 RNU1-136P http://asia.ensembl.org/id/ENSG00000206908 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027342 ENSG00000206932 RNU6-4P http://asia.ensembl.org/id/ENSG00000206932 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027343 ENSG00000206954 RNU6-1201P http://asia.ensembl.org/id/ENSG00000206954 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027344 ENSG00000206965 RNU6-5P http://asia.ensembl.org/id/ENSG00000206965 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027345 ENSG00000206972 RNU6-17P http://asia.ensembl.org/id/ENSG00000206972 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027346 ENSG00000206973 RNU6-1145P http://asia.ensembl.org/id/ENSG00000206973 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027347 ENSG00000206975 RNU6-13P http://asia.ensembl.org/id/ENSG00000206975 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027348 ENSG00000206981 RNU6-40P http://asia.ensembl.org/id/ENSG00000206981 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027349 ENSG00000207000 RNU6-820P http://asia.ensembl.org/id/ENSG00000207000 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027350 ENSG00000207003 RNU6-611P http://asia.ensembl.org/id/ENSG00000207003 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027351 ENSG00000207029 RNU6-43P http://asia.ensembl.org/id/ENSG00000207029 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027352 ENSG00000207041 RNU6-3P http://asia.ensembl.org/id/ENSG00000207041 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027353 ENSG00000207052 RNU6-378P http://asia.ensembl.org/id/ENSG00000207052 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027354 ENSG00000207083 RNU6-22P http://asia.ensembl.org/id/ENSG00000207083 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027355 ENSG00000207099 RNU6-166P http://asia.ensembl.org/id/ENSG00000207099 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027356 ENSG00000207110 RNU1-106P http://asia.ensembl.org/id/ENSG00000207110 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027357 ENSG00000207138 RNU6-869P http://asia.ensembl.org/id/ENSG00000207138 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027358 ENSG00000207154 RNU1-46P http://asia.ensembl.org/id/ENSG00000207154 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027359 ENSG00000207175 RNU1-67P http://asia.ensembl.org/id/ENSG00000207175 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027360 ENSG00000207182 RNU1-44P http://asia.ensembl.org/id/ENSG00000207182 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027361 ENSG00000207201 RNU1-148P http://asia.ensembl.org/id/ENSG00000207201 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027362 ENSG00000207256 RNU6-880P http://asia.ensembl.org/id/ENSG00000207256 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027363 ENSG00000207257 RNU6-18P http://asia.ensembl.org/id/ENSG00000207257 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027364 ENSG00000207296 RNU6-140P http://asia.ensembl.org/id/ENSG00000207296 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027365 ENSG00000207307 RNU6-145P http://asia.ensembl.org/id/ENSG00000207307 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027366 ENSG00000207322 RNU1-89P http://asia.ensembl.org/id/ENSG00000207322 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027367 ENSG00000207334 RNU6-12P http://asia.ensembl.org/id/ENSG00000207334 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027368 ENSG00000207336 RNU6-658P http://asia.ensembl.org/id/ENSG00000207336 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027369 ENSG00000207352 RNU6-540P http://asia.ensembl.org/id/ENSG00000207352 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027370 ENSG00000207367 RNU6-29P http://asia.ensembl.org/id/ENSG00000207367 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027371 ENSG00000207434 RNU6-1072P http://asia.ensembl.org/id/ENSG00000207434 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027372 ENSG00000207454 RNU6-1104P http://asia.ensembl.org/id/ENSG00000207454 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027373 ENSG00000207472 RNU6-41P http://asia.ensembl.org/id/ENSG00000207472 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027374 ENSG00000207483 RNU6-1067P http://asia.ensembl.org/id/ENSG00000207483 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027375 ENSG00000207511 RNU6-771P http://asia.ensembl.org/id/ENSG00000207511 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027376 ENSG00000210841 RNU6ATAC26P http://asia.ensembl.org/id/ENSG00000210841 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027377 ENSG00000212144 U8 http://asia.ensembl.org/id/ENSG00000212144 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027378 ENSG00000212153 RNU1-82P http://asia.ensembl.org/id/ENSG00000212153 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027379 ENSG00000212170 RNU1-77P http://asia.ensembl.org/id/ENSG00000212170 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027380 ENSG00000212424 RNU1-119P http://asia.ensembl.org/id/ENSG00000212424 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027381 ENSG00000212473 RNU1-101P http://asia.ensembl.org/id/ENSG00000212473 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027382 ENSG00000212550 RNU1-78P http://asia.ensembl.org/id/ENSG00000212550 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027383 ENSG00000212605 RNU1-56P http://asia.ensembl.org/id/ENSG00000212605 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027384 ENSG00000221038 RNU6ATAC7P http://asia.ensembl.org/id/ENSG00000221038 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027385 ENSG00000221562 RNU6ATAC10P http://asia.ensembl.org/id/ENSG00000221562 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027386 ENSG00000221719 SNORA3 http://asia.ensembl.org/id/ENSG00000221719 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027387 ENSG00000222126 RNU2-9P http://asia.ensembl.org/id/ENSG00000222126 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027388 ENSG00000222177 RNU4-30P http://asia.ensembl.org/id/ENSG00000222177 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027389 ENSG00000222222 RNU2-17P http://asia.ensembl.org/id/ENSG00000222222 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027390 ENSG00000222276 RNU2-33P http://asia.ensembl.org/id/ENSG00000222276 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027391 ENSG00000222293 RNU2-36P http://asia.ensembl.org/id/ENSG00000222293 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027392 ENSG00000222355 RNU2-29P http://asia.ensembl.org/id/ENSG00000222355 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027393 ENSG00000222389 RNU2-28P http://asia.ensembl.org/id/ENSG00000222389 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027394 ENSG00000222414 RNU2-59P http://asia.ensembl.org/id/ENSG00000222414 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027395 ENSG00000222438 RNU6-1077P http://asia.ensembl.org/id/ENSG00000222438 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027396 ENSG00000222440 RNU2-26P http://asia.ensembl.org/id/ENSG00000222440 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027397 ENSG00000222449 RNU6-1140P http://asia.ensembl.org/id/ENSG00000222449 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027398 ENSG00000222477 RNU2-23P http://asia.ensembl.org/id/ENSG00000222477 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027399 ENSG00000222501 RNU4-25P http://asia.ensembl.org/id/ENSG00000222501 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027400 ENSG00000222612 RNU2-52P http://asia.ensembl.org/id/ENSG00000222612 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027401 ENSG00000222624 RNU2-15P http://asia.ensembl.org/id/ENSG00000222624 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027402 ENSG00000222626 RNU2-48P http://asia.ensembl.org/id/ENSG00000222626 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027403 ENSG00000222627 RNU2-37P http://asia.ensembl.org/id/ENSG00000222627 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027404 ENSG00000222640 RNU2-51P http://asia.ensembl.org/id/ENSG00000222640 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027405 ENSG00000222644 RNU2-16P http://asia.ensembl.org/id/ENSG00000222644 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027406 ENSG00000222650 RNU2-70P http://asia.ensembl.org/id/ENSG00000222650 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027407 ENSG00000222724 RNU2-63P http://asia.ensembl.org/id/ENSG00000222724 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027408 ENSG00000222760 RNU4-53P http://asia.ensembl.org/id/ENSG00000222760 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027409 ENSG00000222788 RNU2-38P http://asia.ensembl.org/id/ENSG00000222788 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027410 ENSG00000222810 RNU2-68P http://asia.ensembl.org/id/ENSG00000222810 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027411 ENSG00000222923 RNU2-41P http://asia.ensembl.org/id/ENSG00000222923 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027412 ENSG00000222985 RNU2-14P http://asia.ensembl.org/id/ENSG00000222985 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027413 ENSG00000223001 RNU2-61P http://asia.ensembl.org/id/ENSG00000223001 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027414 ENSG00000223078 RNU2-55P http://asia.ensembl.org/id/ENSG00000223078 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027415 ENSG00000223119 RNU6-1139P http://asia.ensembl.org/id/ENSG00000223119 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027416 ENSG00000223125 RNU2-32P http://asia.ensembl.org/id/ENSG00000223125 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027417 ENSG00000223247 RNU2-64P http://asia.ensembl.org/id/ENSG00000223247 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027418 ENSG00000223327 RNU2-71P http://asia.ensembl.org/id/ENSG00000223327 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027419 ENSG00000228549 RP11-108M9.3 http://asia.ensembl.org/id/ENSG00000228549 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027420 ENSG00000232019 AC074183.4 http://asia.ensembl.org/id/ENSG00000232019 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027421 ENSG00000232533 AC093673.5 http://asia.ensembl.org/id/ENSG00000232533 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027422 ENSG00000233421 RP5-875O13.1 http://asia.ensembl.org/id/ENSG00000233421 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027423 ENSG00000233461 RP11-295G20.2 http://asia.ensembl.org/id/ENSG00000233461 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027424 ENSG00000234949 AC104667.3 http://asia.ensembl.org/id/ENSG00000234949 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027425 ENSG00000236663 AP001631.9 http://asia.ensembl.org/id/ENSG00000236663 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027426 ENSG00000238554 RNU1-88P http://asia.ensembl.org/id/ENSG00000238554 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027427 ENSG00000238561 RNU6ATAC28P http://asia.ensembl.org/id/ENSG00000238561 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027428 ENSG00000238833 RNU1-131P http://asia.ensembl.org/id/ENSG00000238833 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027429 ENSG00000239023 RNU1-98P http://asia.ensembl.org/id/ENSG00000239023 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027430 ENSG00000239128 snoU13 http://asia.ensembl.org/id/ENSG00000239128 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027431 ENSG00000239178 RNU6-671P http://asia.ensembl.org/id/ENSG00000239178 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027432 ENSG00000246350 RP5-1186N24.3 http://asia.ensembl.org/id/ENSG00000246350 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027433 ENSG00000250920 RP11-297P16.4 http://asia.ensembl.org/id/ENSG00000250920 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027434 ENSG00000251629 RP11-774D14.1 http://asia.ensembl.org/id/ENSG00000251629 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027435 ENSG00000251870 RNU2-69P http://asia.ensembl.org/id/ENSG00000251870 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027436 ENSG00000251954 RNU6-496P http://asia.ensembl.org/id/ENSG00000251954 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027437 ENSG00000251955 RNU6-27P http://asia.ensembl.org/id/ENSG00000251955 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027438 ENSG00000252018 RNU2-30P http://asia.ensembl.org/id/ENSG00000252018 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027439 ENSG00000252145 RNU6-1225P http://asia.ensembl.org/id/ENSG00000252145 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027440 ENSG00000252201 RNU6-1058P http://asia.ensembl.org/id/ENSG00000252201 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027441 ENSG00000252213 SNORA74 http://asia.ensembl.org/id/ENSG00000252213 snoRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027442 ENSG00000252237 RNU4-54P http://asia.ensembl.org/id/ENSG00000252237 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027443 ENSG00000252247 RNU6-70P http://asia.ensembl.org/id/ENSG00000252247 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027444 ENSG00000252311 RNU1-103P http://asia.ensembl.org/id/ENSG00000252311 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027445 ENSG00000252373 RNU6-358P http://asia.ensembl.org/id/ENSG00000252373 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027446 ENSG00000252468 RNU2-57P http://asia.ensembl.org/id/ENSG00000252468 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027447 ENSG00000252635 RNU2-56P http://asia.ensembl.org/id/ENSG00000252635 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027448 ENSG00000252636 RNU6-826P http://asia.ensembl.org/id/ENSG00000252636 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027449 ENSG00000252839 RNU6-419P http://asia.ensembl.org/id/ENSG00000252839 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027450 ENSG00000252847 RNU2-46P http://asia.ensembl.org/id/ENSG00000252847 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027451 ENSG00000252850 RNU1-117P http://asia.ensembl.org/id/ENSG00000252850 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027452 ENSG00000253086 RNU6-537P http://asia.ensembl.org/id/ENSG00000253086 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027453 ENSG00000253089 RNU1-104P http://asia.ensembl.org/id/ENSG00000253089 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027454 ENSG00000253097 RNU2-19P http://asia.ensembl.org/id/ENSG00000253097 snRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027455 ENSG00000253190 AC084082.3 http://asia.ensembl.org/id/ENSG00000253190 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027456 ENSG00000254144 RP11-661A12.4 http://asia.ensembl.org/id/ENSG00000254144 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027457 ENSG00000260464 RP4-561L24.3 http://asia.ensembl.org/id/ENSG00000260464 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027458 ENSG00000261183 RP11-532F12.5 http://asia.ensembl.org/id/ENSG00000261183 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027459 ENSG00000261441 RP11-217B1.2 http://asia.ensembl.org/id/ENSG00000261441 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027460 ENSG00000261519 RP11-403P17.4 http://asia.ensembl.org/id/ENSG00000261519 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027461 ENSG00000261889 RP11-473M20.16 http://asia.ensembl.org/id/ENSG00000261889 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027462 ENSG00000262899 LA16c-360H6.3 http://asia.ensembl.org/id/ENSG00000262899 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027463 ENSG00000264727 RP11-680C21.1 http://asia.ensembl.org/id/ENSG00000264727 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027464 ENSG00000265091 RP11-835E18.5 http://asia.ensembl.org/id/ENSG00000265091 lncRNA Homo sapiens 24393600 Cytosol Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027465 ENSG00000265706 SNORD53_SNORD92 http://asia.ensembl.org/id/ENSG00000265706 snoRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027466 ENSG00000266208 CTD-2267D19.3 http://asia.ensembl.org/id/ENSG00000266208 mRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027467 ENSG00000267321 RP11-1094M14.11 http://asia.ensembl.org/id/ENSG00000267321 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027468 ENSG00000271739 U1 http://asia.ensembl.org/id/ENSG00000271739 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027469 ENSG00000272086 CTD-2186M15.3 http://asia.ensembl.org/id/ENSG00000272086 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027470 ENSG00000272189 RP3-325F22.5 http://asia.ensembl.org/id/ENSG00000272189 lncRNA Homo sapiens 24393600 Ribosome Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027471 ENSG00000272292 U6 http://asia.ensembl.org/id/ENSG00000272292 snRNA Homo sapiens 24393600 Nucleus Colon cancer cell Next-generation sequencing "The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A. " RLID00027472 EU069824 EU069824 http://www.ncbi.nlm.nih.gov/nuccore/?term=EU069824 mRNA Spisula solidissima 22356233 Centrosome Oocyte RT-PCR "TABLE 1: Similarity between centrosome-associated RNAs and viral sequences (from ref. [32], with modifications). Data are collected from Table 1. " RLID00027473 EU199802 EU199802 http://www.ncbi.nlm.nih.gov/nuccore/?term=EU199802 mRNA Clytia hemisphaerica 22309706 Germ plasm Oocyte In situ hybridization Figure 2: Perinuclear concentration of “germ plasm�in growing oocytes. A-E: Characteristic perinuclear distribution of the five mRNAs in very early oocyte stages (cyt: cytoplasm; nu: nucleus). Data are collected from Figure 2. RLID00027474 JQ397273 JQ397273 http://www.ncbi.nlm.nih.gov/nuccore/?term=JQ397273 mRNA Clytia hemisphaerica 22309706 Germ plasm Oocyte In situ hybridization Figure 2: Perinuclear concentration of “germ plasm�in growing oocytes. A-E: Characteristic perinuclear distribution of the five mRNAs in very early oocyte stages (cyt: cytoplasm; nu: nucleus). Data are collected from Figure 2. RLID00027475 JQ397274 JQ397274 http://www.ncbi.nlm.nih.gov/nuccore/?term=JQ397274 mRNA Clytia hemisphaerica 22309706 Germ plasm Oocyte In situ hybridization Figure 2: Perinuclear concentration of “germ plasm�in growing oocytes. A-E: Characteristic perinuclear distribution of the five mRNAs in very early oocyte stages (cyt: cytoplasm; nu: nucleus). Data are collected from Figure 2. RLID00027476 JQ397275 JQ397275 http://www.ncbi.nlm.nih.gov/nuccore/?term=JQ397275 mRNA Clytia hemisphaerica 22309706 Germ plasm Oocyte In situ hybridization Figure 2: Perinuclear concentration of “germ plasm�in growing oocytes. A-E: Characteristic perinuclear distribution of the five mRNAs in very early oocyte stages (cyt: cytoplasm; nu: nucleus). Data are collected from Figure 2. RLID00027477 JQ397276 JQ397276 http://www.ncbi.nlm.nih.gov/nuccore/?term=JQ397276 mRNA Clytia hemisphaerica 22309706 Germ plasm Oocyte In situ hybridization Figure 2: Perinuclear concentration of “germ plasm�in growing oocytes. A-E: Characteristic perinuclear distribution of the five mRNAs in very early oocyte stages (cyt: cytoplasm; nu: nucleus). Data are collected from Figure 2. RLID00027478 KC190025 LincRNA-EPS http://www.ncbi.nlm.nih.gov/nuccore/KC190025 lncRNA Mus musculus 22155924 Nucleus 293T cell RT-PCR "RT-PCR analysis revealed that LincRNA-EPS was predominantly detected in the nuclear fraction (Supplemental Fig. S3A,B). " RLID00027479 KR095173 AS-IL1A http://www.ncbi.nlm.nih.gov/nuccore/?term=KR095173 lncRNA Mus musculus 26179904 Nucleus Macrophage qRT-PCR AS-IL1α is located in the nucleus and did not alter the stability of IL-1α mRNA. AS-IL1a was primarily nuclear (Fig. 4A). RLID00027480 L36162 L36162 http://www.ncbi.nlm.nih.gov/nuccore/L36162 lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00027481 M18237 M18237 http://www.ncbi.nlm.nih.gov/nuccore/M18237 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027482 M73818 M73818 http://www.ncbi.nlm.nih.gov/nuccore/M73818 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00027483 MI0000060 hsa-let-7a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000060 hsa-let-7a-1L miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027484 MI0000060 hsa-let-7a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000060 hsa-let-7a-1L miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027485 MI0000060 hsa-let-7a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000060 hsa-let-7a-1L miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027486 MI0000061 hsa-let-7a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000061 hsa-let-7a-2L miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027487 MI0000061 hsa-let-7a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000061 hsa-let-7a-2L miRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027488 MI0000061 hsa-let-7a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000061 hsa-let-7a-2L miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027489 MI0000062 hsa-let-7a-3 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000062 hsa-let-7a-3L miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027490 MI0000062 hsa-let-7a-3 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000062 hsa-let-7a-3L miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027491 MI0000062 hsa-let-7a-3 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000062 hsa-let-7a-3L miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027492 MI0000063 hsa-let-7b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000063 hsa-let-7bL miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027493 MI0000063 hsa-let-7b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000063 hsa-let-7bL miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00027494 MI0000063 hsa-let-7b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000063 hsa-let-7bL miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00027495 MI0000063 hsa-let-7b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000063 hsa-let-7bL miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027496 MI0000063 hsa-let-7b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000063 hsa-let-7bL miRNA Homo sapiens 21637849 Mitochondrion Myoblast In situ hybridization "In situ hybridization of pre-mir-302a, pre-let-7b and mir-365, using specific labelled locked nucleic acids and confocal microscopy, demonstrated that these miRNA were localized in mitochondria of human myoblasts. Strikingly, we also observed that two pre-miRNAs, pre-mir302a and pre-let-7b were located within mitochondria surrounding the nucleus (Figures 5E, F). The present study demonstrated for the first time the localization of pre-miRNA (pre-mir-302a, pre-let-7b) and miRNA in human mitochondria isolated from muscular cells. " RLID00027497 MI0000063 hsa-let-7b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000063 hsa-let-7bL miRNA Homo sapiens 21637849 Nucleus Skeletal muscular cell In situ hybridizationq|qRT-PCR Mir 365 exhibited a strong signal in the mitochondria but also in some areas of the nucleus (Figure 3D). The same observation was made for pre-let-7b (Figure 3E). RLID00027498 MI0000064 hsa-let-7c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 hsa-let-7cL miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027499 MI0000064 hsa-let-7c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 hsa-let-7cL miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00027500 MI0000064 hsa-let-7c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 hsa-let-7cL miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027501 MI0000064 hsa-let-7c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 hsa-let-7cL miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00027502 MI0000064 hsa-let-7c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 hsa-let-7cL miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00027503 MI0000064 hsa-let-7c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 hsa-let-7cL miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027504 MI0000064 hsa-let-7c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 hsa-let-7cL miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027505 MI0000064 hsa-let-7c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 hsa-let-7cL miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027506 MI0000064 hsa-let-7c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 hsa-let-7cL miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027507 MI0000064 hsa-let-7c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000064 hsa-let-7cL miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00027508 MI0000065 hsa-let-7d http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000065 hsa-let-7dL miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027509 MI0000065 hsa-let-7d http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000065 hsa-let-7dL miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00027510 MI0000066 hsa-let-7e http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000066 hsa-let-7eL miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027511 MI0000067 hsa-let-7f-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000067 hsa-let-7f-1L miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027512 MI0000067 hsa-let-7f-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000067 hsa-let-7f-1L miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027513 MI0000067 hsa-let-7f-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000067 hsa-let-7f-1L miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027514 MI0000068 hsa-let-7f-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000068 hsa-let-7f-2L miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027515 MI0000068 hsa-let-7f-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000068 hsa-let-7f-2L miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027516 MI0000069 hsa-mir-15a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000069 hsa-mir-15 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027517 MI0000070 hsa-mir-16-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000070 "hsa-mir-16-13, hsa-mir-16 " miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027518 MI0000072 hsa-mir-18a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000072 hsa-mir-18 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027519 MI0000074 hsa-mir-19b-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000074 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027520 MI0000076 hsa-mir-20a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 hsa-mir-20 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027521 MI0000076 hsa-mir-20a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 hsa-mir-20 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027522 MI0000076 hsa-mir-20a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000076 hsa-mir-20 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027523 MI0000077 hsa-mir-21 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000077 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027524 MI0000077 hsa-mir-21 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000077 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027525 MI0000077 hsa-mir-21 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000077 miRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027526 MI0000077 hsa-mir-21 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000077 miRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027527 MI0000077 hsa-mir-21 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000077 miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00027528 MI0000077 hsa-mir-21 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000077 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027529 MI0000080 hsa-mir-24-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000080 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027530 MI0000080 hsa-mir-24-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000080 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027531 MI0000081 hsa-mir-24-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000081 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027532 MI0000081 hsa-mir-24-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000081 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027533 MI0000081 hsa-mir-24-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000081 miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00027534 MI0000083 hsa-mir-26a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000083 hsa-mir-26a miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027535 MI0000083 hsa-mir-26a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000083 hsa-mir-26a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027536 MI0000083 hsa-mir-26a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000083 hsa-mir-26a miRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027537 MI0000085 hsa-mir-27a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000085 hsa-mir-27 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027538 MI0000088 hsa-mir-30a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 hsa-mir-30 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027539 MI0000088 hsa-mir-30a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 hsa-mir-30 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027540 MI0000088 hsa-mir-30a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 hsa-mir-30 miRNA Homo sapiens 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00027541 MI0000088 hsa-mir-30a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 hsa-mir-30 miRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027542 MI0000088 hsa-mir-30a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 hsa-mir-30 miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00027543 MI0000088 hsa-mir-30a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 hsa-mir-30 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027544 MI0000088 hsa-mir-30a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 hsa-mir-30 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027545 MI0000088 hsa-mir-30a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000088 hsa-mir-30 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027546 MI0000090 hsa-mir-32 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000090 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027547 MI0000095 hsa-mir-93 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000095 "hsa-mir-93-7.1, hsa-mir-93-1 " miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027548 MI0000095 hsa-mir-93 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000095 "hsa-mir-93-7.1, hsa-mir-93-1 " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027549 MI0000097 hsa-mir-95 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000097 hsa-mir-95-4 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00027550 MI0000097 hsa-mir-95 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000097 hsa-mir-95-4 miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00027551 MI0000098 hsa-mir-96 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000098 hsa-mir-96-7 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027552 MI0000100 hsa-mir-98 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000100 hsa-mir-98-X miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027553 MI0000100 hsa-mir-98 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000100 hsa-mir-98-X miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027554 MI0000101 hsa-mir-99a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000101 "hsa-mir-99-21, hsa-mir-99 " miRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027555 MI0000102 hsa-mir-100 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000102 hsa-mir-100-11 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027556 MI0000102 hsa-mir-100 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000102 hsa-mir-100-11 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027557 MI0000103 hsa-mir-101-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000103 "hsa-mir-101-1, hsa-mir-101 " miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027558 MI0000108 hsa-mir-103a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000108 "hsa-mir-103-20, hsa-mir-103-2 " miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027559 MI0000109 hsa-mir-103a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000109 "hsa-mir-103-5, hsa-mir-103-1 " miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027560 MI0000115 hsa-mir-16-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000115 hsa-mir-16-3 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027561 MI0000118 dme-mir-2a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000118 miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027562 MI0000127 dme-mir-7 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000127 miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027563 MI0000128 dme-mir-8 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000128 miRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027564 MI0000128 dme-mir-8 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000128 miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027565 MI0000131 dme-mir-11 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000131 miRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027566 MI0000131 dme-mir-11 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000131 miRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027567 MI0000131 dme-mir-11 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000131 miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027568 MI0000136 dme-mir-14 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000136 miRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027569 MI0000136 dme-mir-14 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000136 miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027570 MI0000146 mmu-mir-99a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000146 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "As shown in fig. 6, microRNA precursors were readily detected within the SYN fraction, at levels that were comparable to the total homogenate. Data are collected from Figure 6. " RLID00027571 MI0000146 mmu-mir-99a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000146 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Synaptosomes were extracted with non-ionic detergent and measurements were made of the soluble extract vs. the insoluble residue (i.e., the PSD fraction). As shown in fig.17b, the microRNA precursors were all predominantly associated with the PSD fractionIn contrast, the mature microRNAs were predominantly detected in the Triton-soluble fraction (fig. 7b). Data are collected from Figure 7B.. " RLID00027572 MI0000150 mmu-mir-124-3 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000150 "mmu-mir-124a, mmu-mir-124a-3 " miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Synaptosomes were extracted with non-ionic detergent and measurements were made of the soluble extract vs. the insoluble residue (i.e., the PSD fraction). As shown in fig.12b, the microRNA precursors were all predominantly associated with the PSD fractionIn contrast, the mature microRNAs were predominantly detected in the Triton-soluble fraction (fig. 7b). Data are collected from Figure 7B.. " RLID00027573 MI0000152 mmu-mir-125b-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000152 mmu-mir-125b miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "As shown in fig. 6, microRNA precursors were readily detected within the SYN fraction, at levels that were comparable to the total homogenate. Data are collected from Figure 6. " RLID00027574 MI0000152 mmu-mir-125b-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000152 mmu-mir-125b miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Synaptosomes were extracted with non-ionic detergent and measurements were made of the soluble extract vs. the insoluble residue (i.e., the PSD fraction). As shown in fig.14b, the microRNA precursors were all predominantly associated with the PSD fractionIn contrast, the mature microRNAs were predominantly detected in the Triton-soluble fraction (fig. 7b). Data are collected from Figure 7B.. " RLID00027575 MI0000160 mmu-mir-134 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000160 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "As shown in fig. 6, microRNA precursors were readily detected within the SYN fraction, at levels that were comparable to the total homogenate. Data are collected from Figure 6. " RLID00027576 MI0000160 mmu-mir-134 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000160 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Synaptosomes were extracted with non-ionic detergent and measurements were made of the soluble extract vs. the insoluble residue (i.e., the PSD fraction). As shown in fig.15b, the microRNA precursors were all predominantly associated with the PSD fractionIn contrast, the mature microRNAs were predominantly detected in the Triton-soluble fraction (fig. 7b). Data are collected from Figure 7B.. " RLID00027577 MI0000254 hsa-mir-30c-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000254 hsa-mir-30c miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027578 MI0000255 hsa-mir-30d http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000255 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027579 MI0000257 mmu-mir-143 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000257 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Individual microRNAs showed a wide range of relative enrichment ratios (fig.3). The lowest ratio was observed with mir-143, which was ?7-fold less abundant in the SYN fraction than in the total homogenate, whereas on the other hand, mir-200c was ?5-fold more abundant in the SYN fraction. " RLID00027580 MI0000261 hsa-mir-139 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000261 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027581 MI0000263 hsa-mir-7-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000263 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027582 MI0000263 hsa-mir-7-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000263 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027583 MI0000263 hsa-mir-7-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000263 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027584 MI0000269 hsa-mir-181a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000269 hsa-mir-181a miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027585 MI0000272 hsa-mir-182 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000272 hsa-mir-182-as miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027586 MI0000273 hsa-mir-183 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000273 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027587 MI0000279 hsa-mir-196a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000279 hsa-mir-196-2 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027588 MI0000279 hsa-mir-196a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000279 hsa-mir-196-2 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027589 MI0000284 hsa-mir-204 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000284 miRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027590 MI0000285 hsa-mir-205 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000285 miRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027591 MI0000289 hsa-mir-181a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000289 hsa-mir-213 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027592 MI0000292 hsa-mir-216a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000292 hsa-mir-216 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027593 MI0000292 hsa-mir-216a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000292 hsa-mir-216 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027594 MI0000296 hsa-mir-219a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000296 hsa-mir-219 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027595 MI0000298 hsa-mir-221 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000298 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027596 MI0000300 hsa-mir-223 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000300 miRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027597 MI0000343 dme-mir-263a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000343 dme-mir-263 miRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027598 MI0000354 dme-mir-184 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000354 miRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027599 MI0000354 dme-mir-184 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000354 miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027600 MI0000356 dme-mir-275 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000356 miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027601 MI0000357 dme-mir-92a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000357 miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027602 MI0000363 dme-mir-279 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000363 miRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027603 MI0000363 dme-mir-279 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000363 miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027604 MI0000367 dme-mir-282 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000367 miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027605 MI0000368 dme-mir-283 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000368 miRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027606 MI0000370 dme-mir-281-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000370 miRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027607 MI0000370 dme-mir-281-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000370 miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027608 MI0000378 dme-mir-100 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000378 miRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027609 MI0000387 dme-bantam http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000387 "dme-bantam, bantam " miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027610 MI0000409 dme-mir-303 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000409 miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027611 MI0000410 dme-mir-31b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000410 miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027612 MI0000413 dme-mir-9c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000413 miRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027613 MI0000430 dme-mir-318 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000430 miRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00027614 MI0000433 hsa-let-7g http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027615 MI0000433 hsa-let-7g http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000433 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00027616 MI0000434 hsa-let-7i http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000434 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027617 MI0000434 hsa-let-7i http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000434 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00027618 MI0000434 hsa-let-7i http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000434 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027619 MI0000438 hsa-mir-15b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000438 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027620 MI0000439 hsa-mir-23b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000439 miRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027621 MI0000456 hsa-mir-140 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000456 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027622 MI0000458 hsa-mir-142 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000458 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027623 MI0000462 hsa-mir-152 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000462 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027624 MI0000462 hsa-mir-152 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000462 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027625 MI0000462 hsa-mir-152 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000462 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027626 MI0000462 hsa-mir-152 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000462 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027627 MI0000462 hsa-mir-152 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000462 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027628 MI0000466 hsa-mir-9-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000466 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027629 MI0000467 hsa-mir-9-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000467 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027630 MI0000468 hsa-mir-9-3 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000468 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027631 MI0000469 hsa-mir-125a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000469 miRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027632 MI0000471 hsa-mir-126 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000471 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027633 MI0000471 hsa-mir-126 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000471 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027634 MI0000474 hsa-mir-134 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000474 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027635 MI0000474 hsa-mir-134 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000474 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027636 MI0000474 hsa-mir-134 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000474 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00027637 MI0000476 hsa-mir-138-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000476 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027638 MI0000476 hsa-mir-138-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000476 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027639 MI0000483 hsa-mir-186 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000483 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027640 MI0000483 hsa-mir-186 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000483 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027641 MI0000484 hsa-mir-188 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000484 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027642 MI0000621 mmu-mir-339 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000621 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "As shown in fig. 6, microRNA precursors were readily detected within the SYN fraction, at levels that were comparable to the total homogenate. Data are collected from Figure 6. " RLID00027643 MI0000621 mmu-mir-339 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000621 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Synaptosomes were extracted with non-ionic detergent and measurements were made of the soluble extract vs. the insoluble residue (i.e., the PSD fraction). As shown in fig.16b, the microRNA precursors were all predominantly associated with the PSD fractionIn contrast, the mature microRNAs were predominantly detected in the Triton-soluble fraction (fig. 7b). Data are collected from Figure 7B.. " RLID00027644 MI0000694 mmu-mir-200c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000694 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Individual microRNAs showed a wide range of relative enrichment ratios (fig.3). The lowest ratio was observed with mir-143, which was ?7-fold less abundant in the SYN fraction than in the total homogenate, whereas on the other hand, mir-200c was ?5-fold more abundant in the SYN fraction. " RLID00027645 MI0000725 mmu-mir-125b-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000725 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "As shown in fig. 6, microRNA precursors were readily detected within the SYN fraction, at levels that were comparable to the total homogenate. Data are collected from Figure 6. " RLID00027646 MI0000725 mmu-mir-125b-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000725 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Synaptosomes were extracted with non-ionic detergent and measurements were made of the soluble extract vs. the insoluble residue (i.e., the PSD fraction). As shown in fig.13b, the microRNA precursors were all predominantly associated with the PSD fractionIn contrast, the mature microRNAs were predominantly detected in the Triton-soluble fraction (fig. 7b). Data are collected from Figure 7B.. " RLID00027647 MI0000727 hsa-mir-128-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000727 hsa-mir-128b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00027648 MI0000734 hsa-mir-106b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000734 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027649 MI0000734 hsa-mir-106b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000734 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027650 MI0000738 hsa-mir-302a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000738 hsa-mir-302 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00027651 MI0000738 hsa-mir-302a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000738 hsa-mir-302 miRNA Homo sapiens 21637849 Mitochondrion Myoblast In situ hybridization "In situ hybridization of pre-mir-302a, pre-let-7b and mir-365, using specific labelled locked nucleic acids and confocal microscopy, demonstrated that these miRNA were localized in mitochondria of human myoblasts. Strikingly, we also observed that two pre-miRNAs, pre-mir302a and pre-let-7b were located within mitochondria surrounding the nucleus (Figures 5E, F). The present study demonstrated for the first time the localization of pre-miRNA (pre-mir-302a, pre-let-7b) and miRNA in human mitochondria isolated from muscular cells. " RLID00027652 MI0000739 hsa-mir-101-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000739 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027653 MI0000746 hsa-mir-99b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000746 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027654 MI0000746 hsa-mir-99b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000746 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027655 MI0000749 hsa-mir-30e http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000749 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027656 MI0000750 hsa-mir-26a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000750 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027657 MI0000760 hsa-mir-361 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000760 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027658 MI0000767 hsa-mir-365a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000767 hsa-mir-365-1 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "In situ hybridization of pre-mir-302a, pre-let-7b and mir-365, using specific labelled locked nucleic acids and confocal microscopy, demonstrated that these miRNA were localized in mitochondria of human myoblasts. " RLID00027659 MI0000767 hsa-mir-365a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000767 hsa-mir-365-1 miRNA Homo sapiens 21637849 Mitochondrion Myoblast In situ hybridization "In situ hybridization of pre-mir-302a, pre-let-7b and mir-367, using specific labelled locked nucleic acids and confocal microscopy, demonstrated that these miRNA were localized in mitochondria of human myoblasts. The top-20 most detected microRNA in the mitochondria of the human myotubes were mir-720, 133b, 1974, 24, 133a, 125a-5p, 1979, 103, 125b, 103, 221, 23a, let-7b, 423-3p, 106a, 23b, 92a, 193b and 365. Among them, the mir-365, detected by in situ hybridization, was confirmed. " RLID00027660 MI0000767 hsa-mir-365a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000767 hsa-mir-365-1 miRNA Homo sapiens 21637849 Nucleus Skeletal muscular cell In situ hybridizationq|qRT-PCR Mir 365 exhibited a strong signal in the mitochondria but also in some areas of the nucleus (Figure 3D). The same observation was made for pre-let-7b (Figure 3E). RLID00027661 MI0000778 hsa-mir-370 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000778 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027662 MI0000778 hsa-mir-370 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000778 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027663 MI0000778 hsa-mir-370 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000778 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00027664 MI0000782 hsa-mir-374a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000782 hsa-mir-374 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027665 MI0000786 hsa-mir-378a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000786 hsa-mir-378 miRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027666 MI0000786 hsa-mir-378a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000786 hsa-mir-378 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027667 MI0000787 hsa-mir-379 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000787 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027668 MI0000791 hsa-mir-383 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000791 miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00027669 MI0000809 hsa-mir-151a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000809 hsa-mir-151 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027670 MI0000810 hsa-mir-135b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000810 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027671 MI0000811 hsa-mir-148b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000811 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027672 MI0000811 hsa-mir-148b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000811 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027673 MI0000813 hsa-mir-324 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000813 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027674 MI0000815 hsa-mir-339 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000815 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027675 MI0000815 hsa-mir-339 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000815 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027676 MI0000825 hsa-mir-345 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000825 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027677 MI0000856 rno-mir-25 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000856 miRNA Rattus norvegicus 25919946 Cell body DRG neurons Fluorescence in situ hybridization "In cultured DRG neurons, pre-miRNA-25 was visible by FISH in cell body and axons (arrows). " RLID00027678 MI0000856 rno-mir-25 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000856 miRNA Rattus norvegicus 25919946 Axon DRG neurons Fluorescence in situ hybridization "In cultured DRG neurons, pre-miRNA-25 was visible by FISH in cell body and axons (arrows). " RLID00027679 MI0000907 rno-mir-134 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000907 miRNA Rattus norvegicus 23651854 Dendrite Hippocampus Fluorescence in situ hybridization|qRT-PCR "We found that the neuronal precursor-miRNA-134 (pre-miR-134) accumulates in dendrites of hippocampal neurons and at synapses in vivo. Together, our data obtained with synaptosomes, FISH, and compartmentalized neuron cultures support a specific localization of endogenous pre-miR-134 in dendrites of primary hippocampal neurons and at synapses in vivo. " RLID00027680 MI0000907 rno-mir-134 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000907 miRNA Rattus norvegicus 23651854 Synapse Hippocampus Fluorescence in situ hybridization|qRT-PCR "We found that the neuronal precursor-miRNA-134 (pre-miR-134) accumulates in dendrites of hippocampal neurons and at synapses in vivo. Together, our data obtained with synaptosomes, FISH, and compartmentalized neuron cultures support a specific localization of endogenous pre-miR-134 in dendrites of primary hippocampal neurons and at synapses in vivo. " RLID00027681 MI0000912 rno-mir-138-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000912 miRNA Rattus norvegicus 25919946 Cell body DRG neurons PCR "Amplicons for pre-miRNAs-138-1, 150 and 320 were readily visualized in RNA prepared from the cell body. " RLID00027682 MI0000920 rno-mir-150 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000920 miRNA Rattus norvegicus 25919946 Cell body DRG neurons PCR "Amplicons for pre-miRNAs-138-1, 150 and 320 were readily visualized in RNA prepared from the cell body. " RLID00027683 MI0000972 rno-mir-320 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000972 miRNA Rattus norvegicus 25919946 Cell body DRG neurons PCR "Amplicons for pre-miRNAs-138-1, 150 and 320 were readily visualized in RNA prepared from the cell body. " RLID00027684 MI0001150 hsa-mir-196b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001150 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027685 MI0001445 hsa-mir-423 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001445 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027686 MI0001445 hsa-mir-423 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001445 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027687 MI0001448 hsa-mir-425 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001448 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027688 MI0001448 hsa-mir-425 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001448 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027689 MI0001448 hsa-mir-425 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001448 miRNA Homo sapiens 24937531 Exosome Plasma qRT-PCR "For miRNome analysis, two homogeneous samples were created: one by pooling 2 μL of RNA from exosomes of diabetic patients and the other by pooling RNA from exosomes of control subjects. After reverse transcription (mirCURY LNA universal cDNA synthesis kit; Exiqon), the reaction was performed on a serum/plasma focus miRNA PCR panel 384 well (V1.R) (Exiqon) using the ABI 7900HT (Applied Biosystems). The most stable miRNAs (miR-425 and miR-423-5p) were identified by NormFinder and GeNorm, validated on each sample, and used as normalizators for circulating miRNAs. " RLID00027690 MI0001652 hsa-mir-450a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001652 "hsa-mir-450, hsa-mir-450-1 " miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027691 MI0001723 hsa-mir-433 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001723 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00027692 MI0001724 rno-mir-433 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001724 miRNA Rattus norvegicus 25919946 Axon DRG neurons Fluorescence in situ hybridization "Pre-miRNA-433 in the axons of cultured DRG neurons, and sciatic nerve FISH samples showed clear increase in pre-miRNA-433 in axons in vivo after sciatic nerve crush " RLID00027693 MI0001729 hsa-mir-451a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001729 hsa-mir-451 miRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027694 MI0001729 hsa-mir-451a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001729 hsa-mir-451 miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00027695 MI0001729 hsa-mir-451a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001729 hsa-mir-451 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027696 MI0001733 hsa-mir-452 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001733 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027697 MI0001733 hsa-mir-452 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001733 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027698 MI0001733 hsa-mir-452 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0001733 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027699 MI0002412 ssc-mir-106a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002412 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027700 MI0002413 ssc-mir-122 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002413 ssc-mir-122a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027701 MI0002414 ssc-mir-125b-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002414 ssc-mir-125b miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027702 MI0002417 ssc-mir-145 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002417 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027703 MI0002418 ssc-mir-148a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002418 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027704 MI0002419 ssc-mir-15b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002419 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027705 MI0002420 ssc-mir-181b-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002420 ssc-mir-181b miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027706 MI0002421 ssc-mir-184 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002421 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027707 MI0002427 ssc-mir-23a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002427 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027708 MI0002428 ssc-mir-24-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002428 ssc-mir-24 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027709 MI0002429 ssc-mir-26a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002429 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027710 MI0002430 ssc-mir-28 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002430 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027711 MI0002431 ssc-mir-29b-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002431 ssc-mir-29b miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027712 MI0002433 ssc-mir-323 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002433 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027713 MI0002434 ssc-mir-326 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002434 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027714 MI0002435 ssc-mir-7-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002435 ssc-mir-7 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027715 MI0002437 ssc-mir-140 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002437 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027716 MI0002438 ssc-mir-181c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002438 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027717 MI0002439 ssc-mir-183 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002439 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027718 MI0002440 ssc-mir-205 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002440 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027719 MI0002442 ssc-mir-27a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002442 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027720 MI0002445 ssc-let-7c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002445 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027721 MI0002446 ssc-let-7f-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002446 ssc-let-7f miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027722 MI0002447 ssc-let-7i http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002447 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027723 MI0002448 ssc-mir-103-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002448 ssc-mir-103 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027724 MI0002449 ssc-mir-107 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002449 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027725 MI0002450 ssc-mir-124a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002450 ssc-mir-124a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027726 MI0002451 ssc-mir-128-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002451 "ssc-mir-128a, ssc-mir-128 " miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027727 MI0002453 ssc-mir-139 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002453 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027728 MI0002455 ssc-mir-18a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002455 ssc-mir-18 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027729 MI0002456 ssc-mir-186 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002456 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027730 MI0002458 ssc-mir-204 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002458 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027731 MI0002459 ssc-mir-21 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002459 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027732 MI0002460 ssc-mir-29c http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002460 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027733 MI0002461 ssc-mir-30c-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002461 ssc-mir-30c miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027734 MI0002462 ssc-mir-9-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002462 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027735 MI0002463 ssc-mir-9-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002463 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027736 MI0002465 hsa-mir-410 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002465 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00027737 MI0002468 hsa-mir-484 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002468 miRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027738 MI0002470 hsa-mir-486-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0002470 hsa-mir-486 miRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027739 MI0003139 hsa-mir-181d http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003139 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00027740 MI0003184 hsa-mir-500a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003184 hsa-mir-500 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027741 MI0003184 hsa-mir-500a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003184 hsa-mir-500 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027742 MI0003185 hsa-mir-501 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003185 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027743 MI0003187 hsa-mir-450a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003187 hsa-mir-450-2 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027744 MI0003188 hsa-mir-503 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003188 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027745 MI0003188 hsa-mir-503 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003188 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027746 MI0003189 hsa-mir-504 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003189 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027747 MI0003513 hsa-mir-455 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003513 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027748 MI0003560 hsa-mir-92b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003560 miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00027749 MI0003591 hsa-mir-584 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003591 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027750 MI0003609 hsa-mir-597 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003609 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027751 MI0003610 hsa-mir-598 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003610 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00027752 MI0003641 hsa-mir-627 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003641 miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00027753 MI0003642 hsa-mir-628 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003642 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027754 MI0003643 hsa-mir-629 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003643 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027755 MI0003643 hsa-mir-629 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003643 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027756 MI0003646 hsa-mir-33b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003646 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027757 MI0003646 hsa-mir-33b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003646 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027758 MI0003685 hsa-mir-421 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003685 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027759 MI0003686 hsa-mir-542 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003686 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027760 MI0003686 hsa-mir-542 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003686 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027761 MI0003686 hsa-mir-542 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003686 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027762 MI0003763 hsa-mir-767 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003763 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027763 MI0003763 hsa-mir-767 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003763 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027764 MI0003780 hsa-mir-1296 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003780 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027765 MI0003815 hsa-mir-1301 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003815 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00027766 MI0003815 hsa-mir-1301 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003815 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027767 MI0003815 hsa-mir-1301 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0003815 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027768 MI0005416 hsa-mir-675 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005416 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027769 MI0005532 hsa-mir-874 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005532 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00027770 MI0005532 hsa-mir-874 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005532 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00027771 MI0005559 hsa-mir-744 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005559 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027772 MI0005559 hsa-mir-744 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005559 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027773 MI0005561 hsa-mir-877 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005561 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027774 MI0005562 hsa-mir-887 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005562 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). RLID00027775 MI0005762 hsa-mir-940 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0005762 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027776 MI0006273 hsa-mir-1180 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006273 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027777 MI0006273 hsa-mir-1180 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006273 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027778 MI0006273 hsa-mir-1180 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006273 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027779 MI0006311 hsa-mir-1225 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006311 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027780 MI0006313 hsa-mir-1226 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006313 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027781 MI0006326 hsa-mir-1236 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006326 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027782 MI0006353 hsa-mir-1291 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006353 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027783 MI0006353 hsa-mir-1291 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006353 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027784 MI0006383 hsa-mir-1248 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006383 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027785 MI0006383 hsa-mir-1248 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006383 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027786 MI0006419 hsa-mir-1277 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006419 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027787 MI0006442 hsa-mir-664a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006442 hsa-mir-664 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027788 MI0006442 hsa-mir-664a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006442 hsa-mir-664 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027789 MI0006444 hsa-mir-1307 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006444 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027790 MI0006444 hsa-mir-1307 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0006444 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027791 MI0007077 ssc-mir-99b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007077 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027792 MI0007258 hsa-mir-1537 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007258 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027793 MI0007261 hsa-mir-103b-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007261 hsa-mir-103-1-as miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027794 MI0007262 hsa-mir-103b-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0007262 hsa-mir-103-2-as miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027795 MI0008211 ssc-mir-15a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008211 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027796 MI0008213 ssc-mir-16-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008213 ssc-mir-16-2 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027797 MI0008214 ssc-mir-17 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008214 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027798 MI0008215 ssc-mir-30b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008215 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027799 MI0008216 ssc-mir-34a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008216 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027800 MI0008217 ssc-mir-130a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008217 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027801 MI0008218 ssc-mir-185 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008218 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027802 MI0008219 ssc-mir-199b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008219 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027803 MI0008220 ssc-mir-210 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008220 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027804 MI0008221 ssc-mir-221 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008221 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027805 MI0008329 hsa-mir-1908 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0008329 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027806 MI0010678 ssc-mir-101-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010678 ssc-mir-101a-1 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027807 MI0010679 ssc-mir-101-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010679 ssc-mir-101a-2 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027808 MI0010680 ssc-mir-124a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010680 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027809 MI0010681 ssc-mir-133a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010681 ssc-mir-133a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027810 MI0010682 ssc-mir-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010682 ssc-mir-1a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027811 MI0010685 ssc-mir-146b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010685 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027812 MI0010686 ssc-mir-181a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010686 ssc-mir-181a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027813 MI0010688 ssc-mir-30a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0010688 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027814 MI0011284 hsa-mir-2277 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0011284 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027815 MI0011284 hsa-mir-2277 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0011284 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027816 MI0013084 ssc-mir-206 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013084 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027817 MI0013085 ssc-let-7a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013085 ssc-let-7a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027818 MI0013086 ssc-let-7e http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013086 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027819 MI0013087 ssc-let-7g http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013087 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027820 MI0013088 ssc-mir-378-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013088 ssc-mir-378 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027821 MI0013090 ssc-mir-29a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013090 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027822 MI0013091 ssc-mir-30d http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013091 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027823 MI0013092 ssc-mir-30e http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013092 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027824 MI0013093 ssc-mir-199a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013093 ssc-mir-199a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027825 MI0013094 ssc-mir-128-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013094 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027826 MI0013095 ssc-mir-191 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013095 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027827 MI0013097 ssc-mir-320 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013097 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027828 MI0013098 ssc-mir-143 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013098 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027829 MI0013100 ssc-mir-151 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013100 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027830 MI0013101 ssc-mir-10a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013101 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027831 MI0013102 ssc-mir-10b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013102 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027832 MI0013103 ssc-mir-486-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013103 ssc-mir-486 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027833 MI0013104 ssc-mir-152 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013104 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027834 MI0013105 ssc-mir-103-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013105 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027835 MI0013106 ssc-mir-181a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013106 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027836 MI0013107 ssc-mir-181b-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013107 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027837 MI0013108 ssc-mir-181d http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013108 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027838 MI0013109 ssc-mir-27b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013109 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027839 MI0013110 ssc-mir-340-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013110 ssc-mir-340 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027840 MI0013111 ssc-mir-24-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013111 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027841 MI0013112 ssc-mir-23b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013112 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027842 MI0013113 ssc-mir-193a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013113 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027843 MI0013114 ssc-mir-99a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013114 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027844 MI0013115 ssc-mir-125a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013115 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027845 MI0013117 ssc-mir-345-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013117 ssc-mir-345 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027846 MI0013118 ssc-mir-148b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013118 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027847 MI0013120 ssc-mir-365-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013120 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027848 MI0013122 ssc-mir-98 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013122 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027849 MI0013124 ssc-mir-92a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013124 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027850 MI0013125 ssc-mir-92a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013125 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027851 MI0013127 ssc-mir-192 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013127 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027852 MI0013128 ssc-mir-100 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013128 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027853 MI0013130 ssc-mir-374a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013130 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027854 MI0013131 ssc-mir-374b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013131 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027855 MI0013132 ssc-mir-34c-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013132 ssc-mir-34c miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3’UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027856 MI0013134 ssc-mir-142 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013134 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027857 MI0013136 ssc-mir-130b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013136 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027858 MI0013137 ssc-mir-196b-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013137 ssc-mir-196b miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027859 MI0013139 ssc-mir-497 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013139 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027860 MI0013142 ssc-mir-331 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013142 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027861 MI0013143 ssc-mir-504 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013143 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027862 MI0013144 ssc-mir-127 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013144 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027863 MI0013145 ssc-mir-361 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013145 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027864 MI0013147 ssc-mir-1307 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013147 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027865 MI0013148 ssc-mir-1306 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013148 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027866 MI0013149 ssc-mir-339-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013149 ssc-mir-339 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027867 MI0013151 ssc-mir-222 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013151 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027868 MI0013152 ssc-mir-676-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013152 ssc-mir-676 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027869 MI0013153 ssc-mir-342 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013153 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027870 MI0013156 ssc-mir-935 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013156 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027871 MI0013158 ssc-mir-328 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013158 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027872 MI0013159 ssc-mir-19b-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013159 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027873 MI0013160 ssc-mir-19b-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013160 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027874 MI0013161 ssc-mir-574 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013161 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027875 MI0013162 ssc-mir-1839 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013162 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027876 MI0013164 ssc-mir-1285 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013164 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027877 MI0013166 ssc-mir-500 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013166 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027878 MI0013167 ssc-mir-324 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013167 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027879 MI0013169 ssc-mir-129a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013169 ssc-mir-129 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027880 MI0013171 ssc-mir-505 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013171 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027881 MI0013172 ssc-mir-125b-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0013172 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027882 MI0014189 hsa-mir-3160-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0014189 miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00027883 MI0014769 ssc-mir-744 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0014769 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027884 MI0014770 ssc-mir-22 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0014770 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027885 MI0014771 ssc-mir-363-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0014771 ssc-mir-363 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027886 MI0014772 ssc-mir-299 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0014772 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027887 MI0014773 ssc-mir-338 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0014773 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027888 MI0015903 hsa-mir-500b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0015903 miRNA Homo sapiens 22058130 Cytoplasm HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027889 MI0015906 ssc-mir-296 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0015906 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027890 MI0015910 ssc-mir-4331 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0015910 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027891 MI0015911 ssc-mir-382 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0015911 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027892 MI0015913 ssc-mir-362 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0015913 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027893 MI0015917 ssc-mir-4332 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0015917 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027894 MI0015922 ssc-mir-1271 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0015922 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027895 MI0016618 ssc-mir-30c-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0016618 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027896 MI0016620 ssc-mir-149 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0016620 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027897 MI0016621 ssc-mir-199a-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0016621 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027898 MI0016622 ssc-mir-378-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0016622 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027899 MI0016623 ssc-mir-451 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0016623 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027900 MI0016691 csi-MIR156 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0016691 miRNA Citrus sinensis 26033697 Nucleus - Immunoprecipitation The co-immunoprecipitation of viral 24K protein with pre-miR156a or pre-miR171a suggests that the alteration in the processing of these precursors might be caused by a direct or indirect interaction with this particular viral protein. This result is also consistent with the nuclear localization of both miRNA precursors and the CPsV 24K protein. RLID00027901 MI0016699 csi-MIR171a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0016699 miRNA Citrus sinensis 26033697 Nucleus - Immunoprecipitation The co-immunoprecipitation of viral 24K protein with pre-miR156a or pre-miR171a suggests that the alteration in the processing of these precursors might be caused by a direct or indirect interaction with this particular viral protein. This result is also consistent with the nuclear localization of both miRNA precursors and the CPsV 24K protein. RLID00027902 MI0016792 hsa-mir-4449 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0016792 miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00027903 MI0017360 hsa-mir-451b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017360 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027904 MI0017984 ssc-let-7a-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017984 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027905 MI0017986 ssc-mir-129b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017986 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027906 MI0017988 ssc-mir-190b http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017988 ssc-mir-190 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027907 MI0017990 ssc-mir-219a http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017990 ssc-mir-219 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027908 MI0017991 ssc-mir-429 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017991 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027909 MI0017992 ssc-mir-486-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017992 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027910 MI0017993 ssc-mir-491 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017993 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027911 MI0017996 ssc-mir-1343 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017996 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027912 MI0017997 ssc-mir-2320 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0017997 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027913 MI0022120 ssc-let-7d http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0022120 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027914 MI0022121 ssc-let-7f-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0022121 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027915 MI0022124 ssc-mir-20b-1 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0022124 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027916 MI0022125 ssc-mir-20b-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0022125 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027917 MI0022128 ssc-mir-34c-2 http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0022128 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00027918 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00027919 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00027920 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00027921 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00027922 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 24937531 Circulating Plasma qRT-PCR "Quantitative RT-PCR validation confirmed the significant up-regulation of miR-326 (P = .004) and down-regulation of let-7a (P < .001) and let-7f (P = .003). Notably, an inverse negative correlation was found between circulating miR-326 and its putative target adiponectin (p = -0.479, P = .009). " RLID00027923 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00027924 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00027925 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00027926 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00027927 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00027928 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00027929 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 22427800 Exosome Serum RT-PCR The miRNAs tested in serum and saliva samples are shown in Table 1. These miRNAs were selected because they are either ubiquitously expressed or have been reported as biomarkers (Table 1). The relative concentration of these microRNAs was determined by calculating the difference of Ct values between the exosome samples and the exosome-depleted supernatant. A 1-unit difference in the Ct value between the miRNAs isolated from the exosomal pellet or supernatant represents a 2-fold difference in the amount of input miRNA. Data are collected from Table 1: List of miRNAs tested in serum and saliva samples. RLID00027930 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00027931 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00027932 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 24468161 Exosome Breast cancer cell RT-PCR|Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00027933 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00027934 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00027935 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 19011622 Microvesicle Glioblastoma cell qRT-PCR|Microarray "Approximately 4,700 different mRNAs were detected exclusively in microvesicles on both arrays, indicating a selective enrichment process within the microvesicles (Supplementary Table 1). Data are collected from Table S1. " RLID00027936 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00027937 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00027938 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00027939 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00027940 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00027941 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00027942 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00027943 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027944 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00027945 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00027946 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027947 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027948 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00027949 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027950 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027951 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 26304123 Endoplasmic reticulum HEK293 cell Northern blo|RT-PCR "To confirm the association of miRNA and Ago2 protein with rER and associated structures, we fractionated isotonic HEK293 cell lysates on a 3-30% OptiPrep gradient and analyzed the individual fractions. We observed that the majority of Ago2 and let-7a miRNA accumulated with the ER-positive fractions (Fig. 1C). " RLID00027952 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 22529849 Exosome Gastric cancer cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00027953 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 22529849 Exosome Glioblastoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00027954 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00027955 MIMAT0000062 hsa-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000062 hsa-let-7a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00027956 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 22884882 Circulating Plasma Microarray "To explore a potential novel biomarker, we examined the cellular and plasma miRNA profiles in adult T-cell leukemia (ATL) characterized by diverse clinical features. Methods and results : Using CD4-positive cells isolated from 2 non-infected healthy individuals, 3 chronic ATL patients and 3 acute ATL patients, cellular miRNAs were profiled by microarray. The microarray screened 5 miRNAs namely miR-155, let-7g, miR-126, miR-130a and let-7b because of the large difference in their expression in diseased vs. that of healthy controls. " RLID00027957 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00027958 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00027959 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00027960 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00027961 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00027962 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00027963 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00027964 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00027965 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00027966 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00027967 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00027968 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00027969 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00027970 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00027971 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00027972 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00027973 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00027974 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00027975 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00027976 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00027977 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00027978 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00027979 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00027980 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00027981 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00027982 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00027983 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00027984 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00027985 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00027986 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00027987 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027988 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00027989 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 24633190 Circulating Plasma RT-PCR We also selected 1 miRNA (miR-150-5p) from these 3 mildly up-regulated miRNAs that expressed >= 50 copies in at least one group. The expression levels and the related functions of 8 selected miRNAs are shown in Table 2. Data are collected from Table 2. RLID00027990 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027991 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00027992 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 21637849 Mitochondrion Myoblast In situ hybridization|qRT-PCR "Other members of the let-7 familly, detected by RT-qPCR, had putative targets. These results suggested that some miRNA detected in the mitochondria like let-7 familly (let-7b, c, d, e, f, i) and mir-133a could be involved in a mitochondrial mRNA silencing regulation. " RLID00027993 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 22529849 Exosome Gastric cancer cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00027994 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00027995 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00027996 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00027997 MIMAT0000063 hsa-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000063 hsa-let-7b miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00027998 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 21098710 Circulating Serum qRT-PCR "By selecting miRNAs that have 3-fold higher expression in HBV compared with control serum, we identified total of 13 upregulated miRNAs, including miR-375, miR-92a, miR-10a, miR-223, miR-423, miR-23b/a, miR-342-3p, miR-99a, miR-122a, miR-125b, miR-150, and let-7c. As shown in Figure 2, the upregulation of these 13 miRNA expressions in the serum of HBV cases, compared with those of controls, was largely consistent when detected by Solexa in pooled samples and qRT-PCR in individual samples. Data are collected from Figure 2. " RLID00027999 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 23424776 Circulating Blood qRT-PCR|Microarray "Five miRNAs (let-7c, miR-16, miR- 449, miR-181a and miR-181b) were found to exhibit similar expression patterns (p < 0.05) in peripheral blood when compared to data obtained by using bone marrow aspirates from MM patients in other studies. " RLID00028000 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028001 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028002 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028003 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00028004 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028005 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028006 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028007 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028008 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00028009 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00028010 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028011 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028012 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00028013 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028014 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028015 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028016 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00028017 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028018 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028019 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028020 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028021 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028022 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028023 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028024 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00028025 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028026 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 21637849 Mitochondrion Myoblast In situ hybridization|qRT-PCR "Other members of the let-7 familly, detected by RT-qPCR, had putative targets. These results suggested that some miRNA detected in the mitochondria like let-7 familly (let-7b, c, d, e, f, i) and mir-135a could be involved in a mitochondrial mRNA silencing regulation. " RLID00028027 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 22529849 Exosome Gastric cancer cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028028 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028029 MIMAT0000064 hsa-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000064 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028030 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00028031 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028032 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028033 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028034 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 24577456 Circulating Serum qRT-PCR|Next-generation sequencing The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. Table 2 has displayed the data. RLID00028035 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028036 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028037 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028038 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00028039 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028040 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028041 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00028042 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028043 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028044 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028045 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00028046 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00028047 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028048 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028049 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028050 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028051 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028052 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028053 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028054 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00028055 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028056 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00028057 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028058 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028059 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028060 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028061 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 20864815 Cytoplasm Colon cancer cell RT-PCR|Northern blot|Microarray "MicroRNAs such as let-7d, miR-19a, miR-19b and miR-200b, demonstrated nuclear localization at a level similar to that of cytoplasm. " RLID00028062 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 21637849 Mitochondrion Myoblast In situ hybridization|qRT-PCR "Other members of the let-7 familly, detected by RT-qPCR, had putative targets. These results suggested that some miRNA detected in the mitochondria like let-7 familly (let-7b, c, d, e, f, i) and mir-136a could be involved in a mitochondrial mRNA silencing regulation. " RLID00028063 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 22529849 Exosome Gastric cancer cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028064 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028065 MIMAT0000065 hsa-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000065 hsa-let-7d miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00028066 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 21690488 Circulating Plasma qRT-PCR "The expressions of selected miRNAs (miR-296-5p, let-7e, and a human cytomegalovirus [HCMV]-encoded miRNA, hcmv-miR-UL112) were validated independently in plasma samples from 24 hypertensive patients and 22 control subjects. " RLID00028067 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028068 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028069 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028070 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028071 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028072 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028073 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00028074 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028075 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 21924071 Circulating Plasma Microarray "MiR-296-5p (Fold change 0.47, P = 0.013) and miR-133b (Fold change 0.57, P = 0.033) were consistently down-regulated in the patient plasma, whereas let-7e (Fold change 1.62, P = 0.009) and hcmv-miR-UL112 (Fold change 2.72, P = 0.004), one human cytomegalovirus encoded microRNAs, were up-regulated in the patient samples. " RLID00028076 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00028077 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028078 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028079 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028080 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00028081 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00028082 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028083 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028084 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028085 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028086 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028087 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028088 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028089 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00028090 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028091 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028092 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028093 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028094 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 19628621 Nucleolus Myoblast Microarray "Five miRNAs, miR-340-5p, miR-351, miR-494, miR-664, and let-7e, were significantly concentrated (two- to eightfold) in the nucleolus compared with the nucleoplasm and/or the cytoplasm (Fig. 2A; Supplemental Table 1). " RLID00028095 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 21637849 Mitochondrion Myoblast In situ hybridization|qRT-PCR "Other members of the let-7 familly, detected by RT-qPCR, had putative targets. These results suggested that some miRNA detected in the mitochondria like let-7 familly (let-7b, c, d, e, f, i) and mir-138a could be involved in a mitochondrial mRNA silencing regulation. " RLID00028096 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 22529849 Exosome Gastric cancer cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028097 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028098 MIMAT0000066 hsa-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000066 hsa-let-7e miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028099 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028100 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028101 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028102 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 24937531 Circulating Plasma qRT-PCR "Quantitative RT-PCR validation confirmed the significant up-regulation of miR-326 (P = .004) and down-regulation of let-7a (P < .001) and let-7f (P = .003). Notably, an inverse negative correlation was found between circulating miR-326 and its putative target adiponectin (p = -0.479, P = .009). " RLID00028103 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028104 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028105 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00028106 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028107 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028108 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028109 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028110 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00028111 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00028112 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028113 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028114 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00028115 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028116 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028117 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028118 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00028119 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028120 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00028121 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028122 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028123 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028124 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028125 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028126 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 21637849 Mitochondrion Myoblast In situ hybridization|qRT-PCR "Other members of the let-7 familly, detected by RT-qPCR, had putative targets. These results suggested that some miRNA detected in the mitochondria like let-7 familly (let-7b, c, d, e, f, i) and mir-139a could be involved in a mitochondrial mRNA silencing regulation. " RLID00028127 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 22529849 Exosome Gastric cancer cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028128 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028129 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028130 MIMAT0000067 hsa-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000067 hsa-let-7f miRNA Homo sapiens 22997154 Circulating Plasma Microarray "Co-transfection with HBV replicative constructs suggested that let-7f, miR-939 and miR-638 can modulate HBV replication. Therefore, we propose that the miRNA profile constitutes a novel circulating marker that can help to predict response to IFN treatment in CHB patients. " RLID00028131 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028132 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028133 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028134 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028135 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028136 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00028137 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028138 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028139 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00028140 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00028141 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028142 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028143 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00028144 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028145 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028146 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028147 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028148 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00028149 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028150 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028151 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028152 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028153 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028154 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028155 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028156 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028157 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00028158 MIMAT0000068 hsa-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000068 hsa-miR-15a miRNA Homo sapiens 24130905 Circulating Plasma RT-PCR "Overall expression levels of circulating miRNAs: most miRNAs from the designated list were successfully detected (with Ct values between 18 and 35) in virtually all samples. The highest signal was detected for miR-451, -223, -15a, -486-5p, -16, and -21, which is in agreement with literature data " RLID00028159 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00028160 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 20883153 Circulating Plasma qRT-PCR|Microarray "In mild TBI patients (GCS score >=12), miR-765 levels were unchanged, while the plasma levels of miR-92a and miR-16 were significantly increased within the first 24h of injury compared to healthy volunteers, and had AUC values of 0.78 and 0.82, respectively. " RLID00028161 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00028162 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028163 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028164 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028165 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028166 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028167 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028168 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028169 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028170 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028171 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028172 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028173 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00028174 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00028175 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 19011622 Microvesicle Glioblastoma cell qRT-PCR|Microarray "Approximately 4,700 different mRNAs were detected exclusively in microvesicles on both arrays, indicating a selective enrichment process within the microvesicles (Supplementary Table 1). Data are collected from Table S1. " RLID00028176 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028177 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028178 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00028179 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028180 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028181 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028182 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00028183 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028184 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028185 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028186 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028187 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028188 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 24633190 Circulating Plasma RT-PCR We also selected 1 miRNA (miR-150-5p) from these 3 mildly up-regulated miRNAs that expressed >= 50 copies in at least one group. The expression levels and the related functions of 8 selected miRNAs are shown in Table 2. Data are collected from Table 2. RLID00028189 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00028190 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00028191 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028192 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 22529849 Exosome Liver carcinoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028193 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 22529849 Exosome Kidney cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028194 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 22529849 Exosome Glioblastoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028195 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028196 MIMAT0000069 hsa-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000069 hsa-miR-16 miRNA Homo sapiens 24130905 Circulating Plasma RT-PCR "Overall expression levels of circulating miRNAs: most miRNAs from the designated list were successfully detected (with Ct values between 18 and 35) in virtually all samples. The highest signal was detected for miR-451, -223, -15a, -486-5p, -16, and -21, which is in agreement with literature data " RLID00028197 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 22094284 Circulating serum qRT-PCR|RNA-seq "When compared with family schizophrenia patients, circulating miR-219-2-3p, miR-92a, miR-346, let-7g and miR-17 were significantly higher in sporadic schizophrenia ( p < 0.001, Fig. 4 ). On contrary, miR-181b and miR-195 were significantlydown-regulated in sporadic schizophrenia compared with family schizophrenia patients ( p < 0.001), miR-1308 was slightly lower in sporadic schizophrenia compared family schizophrenia patients (0.05 < p < 0.001), and miR-103 was highly consistent between sporadic schizophrenia and family schizophrenia patients ( p > 0.05). These data indicate that there is a close relationship between levels of circulating miRNAs and schizophrenia patients whether they have the family history or not. " RLID00028198 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00028199 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 23056289 Circulating Serum qRT-PCR "Circulating miR-17, miR-20a, miR-29c, and miR-223 combined as non-invasive biomarkers in nasopharyngeal carcinoma. " RLID00028200 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028201 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 24456939 Circulating Plasma - "In gastric cancer, several circulating miRNAs have been studied as potential diagnostic biomarkers by evaluating their amount in serum, plasma and gastric juice (Table 2). Data are collected from Table 2. " RLID00028202 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028203 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00028204 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028205 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028206 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028207 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00028208 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028209 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028210 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028211 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028212 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028213 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00028214 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028215 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028216 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028217 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028218 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028219 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028220 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00028221 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028222 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00028223 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028224 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00028225 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00028226 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028227 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028228 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028229 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028230 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028231 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028232 MIMAT0000070 hsa-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000070 "hsa-miR-17-5p, hsa-miR-17 " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028233 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00028234 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028235 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 19289371 Exosome Plasma Microarray Figure 1: Intensities for specific microRNAs derived from the tumor and exosomes isolated from the plasma of the patients. Data are collected from Figure 1. RLID00028236 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028237 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028238 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028239 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028240 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 21203553 Mitochondrion Prostate epithelial cell Northern blot|RT-PCR|Microarray Our study demonstrates that miR-17* is a negative regulator for three important antioxidant enzymes located in mitochondria. RLID00028241 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028242 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028243 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028244 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028245 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00028246 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00028247 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028248 MIMAT0000071 hsa-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000071 "hsa-miR-17-3p, hsa-miR-17* " miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00028249 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028250 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00028251 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028252 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028253 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028254 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028255 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028256 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00028257 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028258 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028259 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028260 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028261 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028262 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028263 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028264 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028265 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00028266 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00028267 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028268 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028269 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028270 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028271 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028272 MIMAT0000072 hsa-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000072 "hsa-miR-18, hsa-miR-18a " miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028273 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028274 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028275 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028276 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028277 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028278 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028279 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00028280 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028281 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028282 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00028283 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028284 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00028285 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00028286 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028287 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00028288 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028289 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00028290 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028291 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028292 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028293 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028294 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00028295 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 20864815 Cytoplasm Colon cancer cell RT-PCR|Northern blot|Microarray "MicroRNAs such as let-7d, miR-19a, miR-19b and miR-200b, demonstrated nuclear localization at a level similar to that of cytoplasm. " RLID00028296 MIMAT0000073 hsa-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000073 hsa-miR-19a miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028297 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00028298 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028299 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028300 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028301 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028302 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028303 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028304 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028305 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028306 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028307 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028308 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028309 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00028310 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 19011622 Microvesicle Glioblastoma cell qRT-PCR|Microarray "Approximately 4,700 different mRNAs were detected exclusively in microvesicles on both arrays, indicating a selective enrichment process within the microvesicles (Supplementary Table 1). Data are collected from Table S1. " RLID00028311 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028312 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028313 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028314 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028315 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028316 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028317 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00028318 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00028319 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028320 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00028321 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028322 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028323 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028324 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028325 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00028326 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 25126405 Circulating Serum qRT-PCR "Circulating miRNAs in the serum and plasma are remarkably stable and are suggested to have promise as noninvasive biomarkers for neurological and neurodevelopmental disorders. Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated. " RLID00028327 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 20864815 Cytoplasm Colon cancer cell RT-PCR|Northern blot|Microarray "MicroRNAs such as let-7d, miR-19a, miR-19b and miR-200b, demonstrated nuclear localization at a level similar to that of cytoplasm. " RLID00028328 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028329 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 22529849 Exosome Glioblastoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028330 MIMAT0000074 hsa-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000074 hsa-miR-19b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00028331 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 20145944 Circulating Blood RT-PCR|Microarray "Our results highlight four miRNA markers for blood identification (miR-20a, miR-106a, miR-185, and miR-144) and five for semen identification (miR-135a, miR-10a, miR-507, miR-943, and miR-891a). Of those, two miRNA markers for blood (miR-144 and miR-185) and two others for semen (miR-135a and miR-897a) are suggestive to be most useful for body fluid identification in future forensic applications, and the respective RT-PCR assays used here for their detection were highly sensitive, allowing the reliable marker detection from subpicogram amounts of total RNA. Our results proved the applicability of the miRNA approach for forensic body fluids identification. " RLID00028332 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00028333 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00028334 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 23056289 Circulating Serum qRT-PCR "Circulating miR-17, miR-20a, miR-29c, and miR-223 combined as non-invasive biomarkers in nasopharyngeal carcinoma. " RLID00028335 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028336 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 24456939 Circulating Serum - "In gastric cancer, several circulating miRNAs have been studied as potential diagnostic biomarkers by evaluating their amount in serum, plasma and gastric juice (Table 2). Data are collected from Table 2. " RLID00028337 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028338 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00028339 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028340 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028341 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028342 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028343 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028344 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00028345 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028346 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028347 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028348 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00028349 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00028350 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 19011622 Microvesicle Glioblastoma cell qRT-PCR|Microarray "Approximately 4,700 different mRNAs were detected exclusively in microvesicles on both arrays, indicating a selective enrichment process within the microvesicles (Supplementary Table 1). Data are collected from Table S1. " RLID00028351 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028352 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028353 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00028354 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028355 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028356 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028357 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028358 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00028359 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028360 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00028361 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00028362 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028363 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028364 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028365 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028366 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028367 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 23940654 Cytoplasm HeLa cell qRT-PCR|In situ hybridization "The miRNA identified in the qPCR screen to be nucleolus-excluded, miR-20a, was indeed found by ISH to be mostly cytoplasmic. " RLID00028368 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 22529849 Exosome Glioblastoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028369 MIMAT0000075 hsa-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000075 "hsa-miR-20, hsa-miR-20a " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00028370 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 18954897 Circulating Serum qRT-PCR Fig. 2. Median fold-change differences in differentially expressed miRNAs between patient and control serum. Data are collected from Figure 2. RLID00028371 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 22105822 Circulating plasma qRT-PCR "Our study revealed that plasma miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a, and miR-801 were potential circulating markers for diagnosing HCC. The microRNA panel with the seven microRNAs from the multivariate logistic regression model demonstrated high accuracy in the diagnosis of HCC, especially for patients with early BCLC stages (0 and A). " RLID00028372 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00028373 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028374 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028375 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028376 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028377 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 24456939 Circulating Gastric juice - "In gastric cancer, several circulating miRNAs have been studied as potential diagnostic biomarkers by evaluating their amount in serum, plasma and gastric juice (Table 2). Data are collected from Table 2. " RLID00028378 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 24456939 Circulating Plasma - "In gastric cancer, several circulating miRNAs have been studied as potential diagnostic biomarkers by evaluating their amount in serum, plasma and gastric juice (Table 2). Data are collected from Table 2. " RLID00028379 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028380 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00028381 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028382 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028383 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028384 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 19289371 Exosome Plasma Microarray Figure 1: Intensities for specific microRNAs derived from the tumor and exosomes isolated from the plasma of the patients. Data are collected from Figure 1. RLID00028385 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00028386 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028387 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028388 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 21601258 Exosome Ascites qRT-PCR "Fig. 2. Biochemical marker analysis of exosomes. (A) Exosomes isolated from ascites or pleural effusions of tumor or LC patients were analyzed using the indi cated mAb followed by peroxidase-conjugated secondary antibody and ECL detection. 10 μ g exosomes were applied per lane. Note that HSP70, ADAM10, Annexin-1 and CD9 are considered as general exosome markers. HLA-DR was used as a marker for immune cell derived exosomes. Note that in BrCa patients #9�4 samples were derived from pleural effusions and #15 and 16 were from ascites. (B) The content of the indicated miRNAs was quantified by real-time RT-PCR in exosomes from ascites of OvCa (n=10) or LC patients (n=6) or BrCa pleural effusions (n=7). Note, that low Ct values re fl ect high expression levels of the respective miRNA. P-values in the fi gure are indicated as follows: * < 0.05, ** < 0.01 *** < 0.001. Data are collected from Figure 2. " RLID00028389 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00028390 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 22895844 Exosome Colon|Liver|Lung qRT-PCR "When the RNA species within exosomes derived from the three CRC cell lines were examined, the mRNAs of housekeeping genes such as ACTB and GAPDH, the microRNAs such as miR-21, miR-192 and miR-221, and the natural antisense RNAs of LRRC24, MDM2 and CDKN1A genes, were detected. " RLID00028391 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028392 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 23559272 Circulating Serum Microarray "Using microarray-based expression profiling followed by real-time quantitative polymerase chain reaction validation, we compared the levels of a series of circulating miRNAs (miR-21, miR-155, miR-182, and miR-197) in serum from patients with lung cancer (n = 65), pulmonary tuberculosis (n = 29), pneumonia (n = 29), and transudate (n = 16) compared with matched healthy controls (n = 37). " RLID00028393 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028394 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 24373621 Circulating Plasma qRT-PCR "Unsupervised clustering of the expression profiles using the six most regulated miRNAs (miR-425-5p, miR-21-5p, miR-106b-5p, miR-590-5p, miR-574-3p, miR-885-3p) significantly (p = 0.012) separated plasma samples collected prior to treatment from plasma samples collected after two days of radiochemotherapy. " RLID00028395 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00028396 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00028397 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 19011622 Microvesicle Glioblastoma cell qRT-PCR|Microarray "Approximately 4,700 different mRNAs were detected exclusively in microvesicles on both arrays, indicating a selective enrichment process within the microvesicles (Supplementary Table 1). Data are collected from Table S1. " RLID00028398 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028399 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028400 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028401 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00028402 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028403 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028404 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028405 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028406 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028407 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00028408 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028409 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028410 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028411 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028412 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028413 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00028414 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00028415 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 22529849 Exosome Placenta - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028416 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 22529849 Exosome Kidney cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028417 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 22529849 Exosome Glioblastoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028418 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028419 MIMAT0000076 hsa-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000076 hsa-miR-21 miRNA Homo sapiens 24130905 Circulating Plasma RT-PCR "Overall expression levels of circulating miRNAs: most miRNAs from the designated list were successfully detected (with Ct values between 18 and 35) in virtually all samples. The highest signal was detected for miR-451, -223, -15a, -486-5p, -16, and -21, which is in agreement with literature data " RLID00028420 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028421 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028422 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028423 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00028424 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028425 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028426 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028427 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028428 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028429 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028430 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028431 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028432 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028433 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028434 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00028435 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028436 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028437 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028438 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028439 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028440 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00028441 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00028442 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028443 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028444 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028445 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028446 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00028447 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00028448 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028449 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028450 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028451 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 22529849 Exosome Liver carcinoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028452 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028453 MIMAT0000077 hsa-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000077 hsa-miR-22 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00028454 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 21098710 Circulating Serum qRT-PCR "By selecting miRNAs that have 3-fold higher expression in HBV compared with control serum, we identified total of 13 upregulated miRNAs, including miR-375, miR-92a, miR-10a, miR-223, miR-423, miR-23b/a, miR-342-3p, miR-99a, miR-122a, miR-125b, miR-150, and let-7c. As shown in Figure 2, the upregulation of these 13 miRNA expressions in the serum of HBV cases, compared with those of controls, was largely consistent when detected by Solexa in pooled samples and qRT-PCR in individual samples. Data are collected from Figure 2. " RLID00028455 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028456 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028457 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028458 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 24981880 Circulating Serum qRT-PCR "Results from recent studies revealed that circulating miRNAs are also potential diagnostic biomarkers and prognostic factors in diabetes. The results of qRT-PCR assessment revealed low serum levels of miR-23a, let-7i, miR-486, miR-96, miR-186, miR-191, miR-192, and miR-146a in T2D. " RLID00028459 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00028460 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028461 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028462 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028463 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028464 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00028465 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028466 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028467 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028468 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028469 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028470 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028471 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028472 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028473 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028474 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028475 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028476 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00028477 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028478 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00028479 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028480 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00028481 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00028482 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028483 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028484 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028485 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028486 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00028487 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00028488 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028489 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028490 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028491 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 22529849 Exosome Liver carcinoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028492 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028493 MIMAT0000078 hsa-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000078 hsa-miR-23a miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00028494 MIMAT0000079 hsa-miR-24-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000079 "hsa-miR-189, hsa-miR-24-1* " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028495 MIMAT0000079 hsa-miR-24-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000079 "hsa-miR-189, hsa-miR-24-1* " miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00028496 MIMAT0000079 hsa-miR-24-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000079 "hsa-miR-189, hsa-miR-24-1* " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028497 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 23424776 Circulating Blood qRT-PCR|Microarray "Five miRNAs (let-7c, miR-16, miR- 449, miR-181a and miR-181b) were found to exhibit similar expression patterns (p < 0.05) in peripheral blood when compared to data obtained by using bone marrow aspirates from MM patients in other studies. " RLID00028498 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028499 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028500 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028501 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028502 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028503 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028504 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028505 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00028506 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028507 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028508 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028509 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028510 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028511 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028512 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00028513 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028514 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028515 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028516 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028517 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00028518 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028519 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028520 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028521 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028522 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028523 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 24633190 Circulating Plasma RT-PCR We also selected 1 miRNA (miR-150-5p) from these 3 mildly up-regulated miRNAs that expressed >= 50 copies in at least one group. The expression levels and the related functions of 8 selected miRNAs are shown in Table 2. Data are collected from Table 2. RLID00028524 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028525 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028526 MIMAT0000080 hsa-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000080 hsa-miR-24 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00028527 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00028528 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028529 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028530 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028531 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028532 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00028533 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028534 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028535 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00028536 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028537 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028538 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028539 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028540 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028541 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00028542 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028543 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028544 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00028545 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028546 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028547 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028548 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00028549 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028550 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028551 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028552 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028553 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028554 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028555 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00028556 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028557 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028558 MIMAT0000081 hsa-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000081 hsa-miR-25 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028559 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 20857419 Circulating Serum Microarray "Microarray analysis of miRNAs was performed on human aortic SMCs undergoing phenotypic switching in response to serum withdrawal, and identified 31 significantly regulated entities. We chose the highly conserved candidate miRNA-26a for additional studies. " RLID00028560 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 22105822 Circulating plasma qRT-PCR "Our study revealed that plasma miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a, and miR-801 were potential circulating markers for diagnosing HCC. The microRNA panel with the seven microRNAs from the multivariate logistic regression model demonstrated high accuracy in the diagnosis of HCC, especially for patients with early BCLC stages (0 and A). " RLID00028561 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028562 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028563 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028564 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028565 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00028566 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028567 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028568 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00028569 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028570 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028571 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028572 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028573 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00028574 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00028575 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00028576 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 19011622 Microvesicle Glioblastoma cell qRT-PCR|Microarray "Approximately 4,700 different mRNAs were detected exclusively in microvesicles on both arrays, indicating a selective enrichment process within the microvesicles (Supplementary Table 1). Data are collected from Table S1. " RLID00028577 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028578 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028579 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028580 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028581 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028582 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028583 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00028584 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00028585 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00028586 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028587 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 25238238 Circulating Serum qRT-PCR "Our study revealed that serum hsa-miR-206, hsa-miR-141-3p, hsa-miR-433-3p, hsa-miR-1228-5p, hsa-miR-199a-5p, hsa-miR-122-5p, hsa-miR-192-5p, and hsa-miR-26a-5p were potential circulating markers for HCC diagnosis. " RLID00028588 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028589 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028590 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028591 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028592 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 22529849 Exosome Glioblastoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028593 MIMAT0000082 hsa-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000082 hsa-miR-26a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028594 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028595 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028596 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028597 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028598 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028599 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028600 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00028601 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028602 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028603 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00028604 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028605 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028606 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028607 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00028608 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028609 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028610 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028611 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028612 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028613 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00028614 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028615 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028616 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028617 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028618 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028619 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00028620 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00028621 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028622 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 22529849 Exosome Liver carcinoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028623 MIMAT0000083 hsa-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000083 hsa-miR-26b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028624 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 22105822 Circulating Plasma qRT-PCR "Our study revealed that plasma miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a, and miR-801 were potential circulating markers for diagnosing HCC. The microRNA panel with the seven microRNAs from the multivariate logistic regression model demonstrated high accuracy in the diagnosis of HCC, especially for patients with early BCLC stages (0 and A). " RLID00028625 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028626 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028627 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028628 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028629 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 24456939 Circulating Serum - "In gastric cancer, several circulating miRNAs have been studied as potential diagnostic biomarkers by evaluating their amount in serum, plasma and gastric juice (Table 2). Data are collected from Table 2. " RLID00028630 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028631 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028632 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028633 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028634 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00028635 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028636 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028637 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00028638 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028639 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028640 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028641 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 19011622 Microvesicle Glioblastoma cell qRT-PCR|Microarray "Approximately 4,700 different mRNAs were detected exclusively in microvesicles on both arrays, indicating a selective enrichment process within the microvesicles (Supplementary Table 1). Data are collected from Table S1. " RLID00028642 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028643 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028644 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00028645 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028646 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028647 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028648 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028649 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028650 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028651 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028652 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028653 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 24633190 Circulating Plasma RT-PCR We also selected 1 miRNA (miR-150-5p) from these 3 mildly up-regulated miRNAs that expressed >= 50 copies in at least one group. The expression levels and the related functions of 8 selected miRNAs are shown in Table 2. Data are collected from Table 2. RLID00028654 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 24577456 Circulating Serum Next-generation sequencing The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. Table 2 has displayed the data. RLID00028655 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 22529849 Exosome Glioblastoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028656 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028657 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028658 MIMAT0000084 hsa-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000084 hsa-miR-27a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028659 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028660 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028661 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028662 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00028663 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028664 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028665 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028666 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028667 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028668 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028669 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028670 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00028671 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028672 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028673 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028674 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028675 MIMAT0000085 hsa-miR-28-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000085 hsa-miR-28 miRNA Homo sapiens 24633190 Circulating Plasma RT-PCR We also selected 1 miRNA (miR-150-5p) from these 3 mildly up-regulated miRNAs that expressed >= 50 copies in at least one group. The expression levels and the related functions of 8 selected miRNAs are shown in Table 2. Data are collected from Table 2. RLID00028676 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 18954897 Circulating Serum qRT-PCR Fig. 2. Median fold-change differences in differentially expressed miRNAs between patient and control serum. Data are collected from Figure 2. RLID00028677 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028678 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028679 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028680 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028681 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028682 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028683 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028684 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028685 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028686 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028687 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028688 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028689 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 19951903 Microvesicle Plasma qRT-PCR|Microarray "Thus, miR-29a was up-regulated in both blood microvesicles and colon tissue of IBS patients with increased membrane permeability. " RLID00028690 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028691 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028692 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028693 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00028694 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028695 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028696 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028697 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028698 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028699 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00028700 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028701 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028702 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028703 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028704 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00028705 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00028706 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028707 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028708 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 22529849 Exosome Liver carcinoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028709 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028710 MIMAT0000086 hsa-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000086 hsa-miR-29a miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00028711 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028712 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028713 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028714 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028715 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028716 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028717 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028718 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028719 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028720 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028721 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028722 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00028723 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028724 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028725 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028726 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00028727 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028728 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028729 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028730 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028731 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028732 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028733 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00028734 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028735 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028736 MIMAT0000087 hsa-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000087 "hsa-miR-30a-5p, hsa-miR-30a " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028737 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028738 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028739 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028740 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028741 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028742 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028743 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028744 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028745 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028746 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028747 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028748 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028749 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028750 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028751 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00028752 MIMAT0000088 hsa-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000088 "hsa-miR-30a-3p, hsa-miR-30a* " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028753 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028754 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028755 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028756 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028757 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00028758 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028759 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028760 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028761 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028762 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028763 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028764 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028765 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028766 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028767 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028768 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00028769 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028770 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028771 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028772 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028773 MIMAT0000089 hsa-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000089 hsa-miR-31 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028774 MIMAT0000090 hsa-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000090 hsa-miR-32 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028775 MIMAT0000090 hsa-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000090 hsa-miR-32 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028776 MIMAT0000090 hsa-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000090 hsa-miR-32 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028777 MIMAT0000090 hsa-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000090 hsa-miR-32 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028778 MIMAT0000090 hsa-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000090 hsa-miR-32 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028779 MIMAT0000090 hsa-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000090 hsa-miR-32 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00028780 MIMAT0000090 hsa-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000090 hsa-miR-32 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028781 MIMAT0000090 hsa-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000090 hsa-miR-32 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028782 MIMAT0000090 hsa-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000090 hsa-miR-32 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028783 MIMAT0000090 hsa-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000090 hsa-miR-32 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028784 MIMAT0000090 hsa-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000090 hsa-miR-32 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028785 MIMAT0000090 hsa-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000090 hsa-miR-32 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028786 MIMAT0000090 hsa-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000090 hsa-miR-32 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00028787 MIMAT0000090 hsa-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000090 hsa-miR-32 miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028788 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028789 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028790 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028791 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028792 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028793 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028794 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028795 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028796 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028797 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028798 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028799 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028800 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028801 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028802 MIMAT0000091 hsa-miR-33a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000091 "hsa-miR-33, hsa-miR-33a " miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028803 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 18954897 Circulating Serum qRT-PCR Fig. 2. Median fold-change differences in differentially expressed miRNAs between patient and control serum. Data are collected from Figure 2. RLID00028804 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00028805 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 20883153 Circulating Plasma qRT-PCR|Microarray "In mild TBI patients (GCS score >=12), miR-765 levels were unchanged, while the plasma levels of miR-92a and miR-16 were significantly increased within the first 24h of injury compared to healthy volunteers, and had AUC values of 0.78 and 0.82, respectively. " RLID00028806 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 21098710 Circulating Serum qRT-PCR "By selecting miRNAs that have 3-fold higher expression in HBV compared with control serum, we identified total of 13 upregulated miRNAs, including miR-375, miR-92a, miR-10a, miR-223, miR-423, miR-23b/a, miR-342-3p, miR-99a, miR-122a, miR-125b, miR-150, and let-7c. As shown in Figure 2, the upregulation of these 13 miRNA expressions in the serum of HBV cases, compared with those of controls, was largely consistent when detected by Solexa in pooled samples and qRT-PCR in individual samples. Data are collected from Figure 2. " RLID00028807 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 21383985 Circulating Plasma qRT-PCR DLBCL patients with low plasma miR-92a relapsed significantly compared with those with normal range plasma miR-92a (5/12 versus 1/22; P?=?.007 by the chi-square test; Table 1). RLID00028808 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 22094284 Circulating serum qRT-PCR|RNA-seq "When compared with family schizophrenia patients, circulating miR-219-2-3p, miR-92a, miR-346, let-7g and miR-17 were significantly higher in sporadic schizophrenia ( p < 0.001, Fig. 4 ). On contrary, miR-181b and miR-195 were significantlydown-regulated in sporadic schizophrenia compared with family schizophrenia patients ( p < 0.001), miR-1308 was slightly lower in sporadic schizophrenia compared family schizophrenia patients (0.05 < p < 0.001), and miR-103 was highly consistent between sporadic schizophrenia and family schizophrenia patients ( p > 0.05). These data indicate that there is a close relationship between levels of circulating miRNAs and schizophrenia patients whether they have the family history or not. " RLID00028809 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00028810 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00028811 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028812 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028813 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028814 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028815 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028816 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028817 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028818 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00028819 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028820 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028821 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 22427800 Circulating Serum RT-PCR The miRNAs tested in serum and saliva samples are shown in Table 1. These miRNAs were selected because they are either ubiquitously expressed or have been reported as biomarkers (Table 1). The relative concentration of these microRNAs was determined by calculating the difference of Ct values between the exosome samples and the exosome-depleted supernatant. A 1-unit difference in the Ct value between the miRNAs isolated from the exosomal pellet or supernatant represents a 2-fold difference in the amount of input miRNA. Data are collected from Table 1: List of miRNAs tested in serum and saliva samples. RLID00028822 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028823 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028824 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00028825 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 19011622 Microvesicle Glioblastoma cell qRT-PCR|Microarray "Approximately 4,700 different mRNAs were detected exclusively in microvesicles on both arrays, indicating a selective enrichment process within the microvesicles (Supplementary Table 1). Data are collected from Table S1. " RLID00028826 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028827 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028828 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028829 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028830 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028831 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028832 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028833 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028834 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00028835 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 25165030 Circulating Serum RT-PCR "Although serum microRNAs (miRNAs) play essential roles in the diagnosis of various diseases, little is known about circulating miRNAs in the aging process. Solexa sequencing demonstrated 17 markedly altered miRNAs in the aging process. Quantitative reversn-PCR analysis identified five downregulated miRNAs (miR-29b, miR-106b, miR-130b, miR-142-5p, and miR-340) and three upregulated miRNAs (miR-92a, miR-222, and miR-375) with age. " RLID00028836 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00028837 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028838 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028839 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028840 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028841 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 24105805 Cytoplasm Umbilical vein endothelial cell TEPA-PCL "Our data indicated that miR-92a-C formulated in TEPA-PCL accumulated in and was spread throughout the cytoplasm in a time-dependent manner, and was taken up into the cells by macropinosome-mediated endocytosis. " RLID00028842 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028843 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 22529849 Exosome Glioblastoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028844 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028845 MIMAT0000092 hsa-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000092 "hsa-miR-92, hsa-miR-92a " miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00028846 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 18954897 Circulating Serum qRT-PCR Fig. 2. Median fold-change differences in differentially expressed miRNAs between patient and control serum. Data are collected from Figure 2. RLID00028847 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028848 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028849 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028850 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028851 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00028852 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00028853 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028854 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028855 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028856 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028857 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028858 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028859 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028860 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00028861 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00028862 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00028863 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 19011622 Microvesicle Glioblastoma cell qRT-PCR|Microarray "Approximately 4,700 different mRNAs were detected exclusively in microvesicles on both arrays, indicating a selective enrichment process within the microvesicles (Supplementary Table 1). Data are collected from Table S1. " RLID00028864 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028865 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028866 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00028867 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028868 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028869 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028870 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028871 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00028872 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028873 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028874 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028875 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028876 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028877 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028878 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 22529849 Exosome Glioblastoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028879 MIMAT0000093 hsa-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000093 hsa-miR-93 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028880 MIMAT0000094 hsa-miR-95-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000094 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028881 MIMAT0000094 hsa-miR-95-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000094 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028882 MIMAT0000094 hsa-miR-95-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000094 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028883 MIMAT0000094 hsa-miR-95-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000094 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028884 MIMAT0000094 hsa-miR-95-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000094 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028885 MIMAT0000094 hsa-miR-95-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000094 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028886 MIMAT0000094 hsa-miR-95-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000094 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028887 MIMAT0000094 hsa-miR-95-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000094 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028888 MIMAT0000094 hsa-miR-95-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000094 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00028889 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00028890 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 24981880 Circulating Serum qRT-PCR "Results from recent studies revealed that circulating miRNAs are also potential diagnostic biomarkers and prognostic factors in diabetes. The results of qRT-PCR assessment revealed low serum levels of miR-23a, let-7i, miR-486, miR-96, miR-186, miR-191, miR-192, and miR-146a in T2D. " RLID00028891 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028892 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028893 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028894 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028895 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028896 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00028897 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00028898 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028899 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028900 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028901 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00028902 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028903 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028904 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028905 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028906 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028907 MIMAT0000095 hsa-miR-96-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000095 hsa-miR-96 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028908 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028909 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028910 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028911 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028912 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028913 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00028914 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028915 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028916 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028917 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028918 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028919 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028920 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028921 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00028922 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 25330373 Microvesicle Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00028923 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028924 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028925 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028926 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 24577456 Circulating Serum Next-generation sequencing The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. Table 2 has displayed the data. RLID00028927 MIMAT0000096 hsa-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000096 hsa-miR-98 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028928 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 21098710 Circulating Serum qRT-PCR "By selecting miRNAs that have 3-fold higher expression in HBV compared with control serum, we identified total of 13 upregulated miRNAs, including miR-375, miR-92a, miR-10a, miR-223, miR-423, miR-23b/a, miR-342-3p, miR-99a, miR-122a, miR-125b, miR-150, and let-7c. As shown in Figure 2, the upregulation of these 13 miRNA expressions in the serum of HBV cases, compared with those of controls, was largely consistent when detected by Solexa in pooled samples and qRT-PCR in individual samples. Data are collected from Figure 2. " RLID00028929 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028930 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028931 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028932 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00028933 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00028934 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028935 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00028936 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00028937 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028938 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028939 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028940 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028941 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028942 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028943 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028944 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028945 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028946 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028947 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028948 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028949 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00028950 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028951 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028952 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028953 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028954 MIMAT0000097 hsa-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000097 hsa-miR-99a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00028955 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028956 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028957 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00028958 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00028959 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00028960 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028961 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00028962 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028963 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028964 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00028965 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00028966 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028967 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00028968 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00028969 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00028970 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028971 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028972 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028973 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00028974 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00028975 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00028976 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028977 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028978 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028979 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00028980 MIMAT0000098 hsa-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000098 hsa-miR-100 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00028981 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028982 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00028983 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028984 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00028985 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028986 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00028987 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00028988 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00028989 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00028990 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In contrast to oncomirs, an miRNA that is involved in tumor-suppressing activities, is taken as a tumor suppressor (oncosuppressor). The aberrantly expressed miR-223, which directly targeted Stathmin 1 to inhibit HCC growth, was only found in MVs of liver cancer cell line in our study (table 2). Data are collected from Table 2. " RLID00028991 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00028992 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028993 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00028994 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00028995 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00028996 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00028997 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028998 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00028999 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029000 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029001 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 25126405 Circulating Serum qRT-PCR "Circulating miRNAs in the serum and plasma are remarkably stable and are suggested to have promise as noninvasive biomarkers for neurological and neurodevelopmental disorders. Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated. " RLID00029002 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029003 MIMAT0000099 hsa-miR-101-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000099 hsa-miR-101 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029004 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029005 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029006 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00029007 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029008 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029009 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029010 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029011 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029012 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029013 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029014 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 17204650 Nucleus HeLa cell In situ hybridization|RT-PCR "We showed that human miR-29b, in contrast to other studied animal miRNAs, is predominantly localized to the nucleus. " RLID00029015 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029016 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 25165030 Circulating Serum RT-PCR "Although serum microRNAs (miRNAs) play essential roles in the diagnosis of various diseases, little is known about circulating miRNAs in the aging process. Solexa sequencing demonstrated 17 markedly altered miRNAs in the aging process. Quantitative reversn-PCR analysis identified five downregulated miRNAs (miR-29b, miR-106b, miR-130b, miR-142-5p, and miR-340) and three upregulated miRNAs (miR-92a, miR-222, and miR-375) with age. " RLID00029017 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029018 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029019 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029020 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029021 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029022 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00029023 MIMAT0000100 hsa-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000100 hsa-miR-29b miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00029024 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00029025 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 22094284 Circulating serum qRT-PCR|RNA-seq "When compared with family schizophrenia patients, circulating miR-219-2-3p, miR-92a, miR-346, let-7g and miR-17 were significantly higher in sporadic schizophrenia ( p < 0.001, Fig. 4 ). On contrary, miR-181b and miR-195 were significantlydown-regulated in sporadic schizophrenia compared with family schizophrenia patients ( p < 0.001), miR-1308 was slightly lower in sporadic schizophrenia compared family schizophrenia patients (0.05 < p < 0.001), and miR-103 was highly consistent between sporadic schizophrenia and family schizophrenia patients ( p > 0.05). These data indicate that there is a close relationship between levels of circulating miRNAs and schizophrenia patients whether they have the family history or not. " RLID00029026 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029027 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029028 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029029 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00029030 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029031 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00029032 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00029033 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029034 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029035 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029036 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029037 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00029038 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00029039 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029040 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029041 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029042 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029043 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029044 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029045 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00029046 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00029047 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029048 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029049 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029050 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029051 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 24865854 Circulating Plasma qRT-PCR|Next-generation sequcencing "Further exploration of their levels in the plasma of CAD patient and control cases, only circulating miR-361-5p and miR-484 were more abundant in CAD cases by RT-qPCR (Fig. 2D). Levels of circulating miR-140-5p showed no different between healthy and disease population (Fig. 2D). Moreover, levels of miR-342-3p, miR-125b-5p, miR-34a-5p, miR-103a-3p, and miR-125a-5p were even reduced significantly in patient circulation (Fig. 2D). " RLID00029052 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029053 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029054 MIMAT0000101 hsa-miR-103a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000101 "hsa-miR-103, hsa-miR-103a " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029055 MIMAT0000102 hsa-miR-105-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000102 hsa-miR-105 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029056 MIMAT0000102 hsa-miR-105-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000102 hsa-miR-105 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029057 MIMAT0000102 hsa-miR-105-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000102 hsa-miR-105 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029058 MIMAT0000102 hsa-miR-105-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000102 hsa-miR-105 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029059 MIMAT0000102 hsa-miR-105-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000102 hsa-miR-105 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029060 MIMAT0000102 hsa-miR-105-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000102 hsa-miR-105 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029061 MIMAT0000102 hsa-miR-105-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000102 hsa-miR-105 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029062 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 20145944 Circulating Blood RT-PCR|Microarray "Our results highlight four miRNA markers for blood identification (miR-20a, miR-106a, miR-185, and miR-144) and five for semen identification (miR-135a, miR-10a, miR-507, miR-943, and miR-891a). Of those, two miRNA markers for blood (miR-144 and miR-185) and two others for semen (miR-135a and miR-897a) are suggestive to be most useful for body fluid identification in future forensic applications, and the respective RT-PCR assays used here for their detection were highly sensitive, allowing the reliable marker detection from subpicogram amounts of total RNA. Our results proved the applicability of the miRNA approach for forensic body fluids identification. " RLID00029063 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00029064 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029065 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 24456939 Circulating Gastric juice - "In gastric cancer, several circulating miRNAs have been studied as potential diagnostic biomarkers by evaluating their amount in serum, plasma and gastric juice (Table 2). Data are collected from Table 2. " RLID00029066 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 24456939 Circulating Plasma - "In gastric cancer, several circulating miRNAs have been studied as potential diagnostic biomarkers by evaluating their amount in serum, plasma and gastric juice (Table 2). Data are collected from Table 2. " RLID00029067 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00029068 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00029069 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029070 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 19289371 Exosome Plasma Microarray Figure 1: Intensities for specific microRNAs derived from the tumor and exosomes isolated from the plasma of the patients. Data are collected from Figure 1. RLID00029071 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00029072 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029073 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029074 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029075 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 24670448 Circulating Plasma Microarray|RT-PCR The plasma levels of miR-106a expression were significantly higher in the cancer patients than in the healthy control group (P=0.012). RLID00029076 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00029077 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00029078 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029079 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029080 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029081 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029082 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029083 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029084 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00029085 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00029086 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00029087 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029088 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029089 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029090 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029091 MIMAT0000103 hsa-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000103 hsa-miR-106a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029092 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00029093 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029094 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029095 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029096 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00029097 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00029098 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029099 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00029100 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029101 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029102 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029103 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029104 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029105 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029106 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00029107 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00029108 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029109 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00029110 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029111 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029112 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029113 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029114 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00029115 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029116 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00029117 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00029118 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029119 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029120 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029121 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029122 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029123 MIMAT0000104 hsa-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000104 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00029124 MIMAT0000121 mmu-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000121 mmu-let-7g miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00029125 MIMAT0000121 mmu-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000121 mmu-let-7g miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029126 MIMAT0000121 mmu-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000121 mmu-let-7g miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029127 MIMAT0000121 mmu-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000121 mmu-let-7g miRNA Mus musculus 21862971 Nucleus Liver cell Microarray "Supplementary information, Figure S4 Screening for the target miRNAs of miR-709 in the nucleus via microarray assay (only top 44 miRNAs were showed). Data are collected from Figure S4. " RLID00029128 MIMAT0000121 mmu-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000121 mmu-let-7g miRNA Mus musculus 23897634 Cell body Neuron ball cultures Fluorescence in situ hybridization Data are collected from Table 2: Cell Body-Enriched miRNAs. RLID00029129 MIMAT0000122 mmu-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000122 mmu-let-7i miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029130 MIMAT0000122 mmu-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000122 mmu-let-7i miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029131 MIMAT0000122 mmu-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000122 mmu-let-7i miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029132 MIMAT0000122 mmu-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000122 mmu-let-7i miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029133 MIMAT0000123 mmu-miR-1a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000123 "mmu-miR-1, mmu-miR-1a " miRNA Mus musculus 25083871 Mitochondrion Myoblast qRT-PCR|Northern blot|CLIP-seq "Here, we report that miR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it unexpectedly stimulates, rather than represses, the translation of specific mitochondrial genome-encoded transcripts. " RLID00029134 MIMAT0000123 mmu-miR-1a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000123 "mmu-miR-1, mmu-miR-1a " miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029135 MIMAT0000123 mmu-miR-1a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000123 "mmu-miR-1, mmu-miR-1a " miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00029136 MIMAT0000124 mmu-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000124 mmu-miR-15b miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029137 MIMAT0000124 mmu-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000124 mmu-miR-15b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029138 MIMAT0000124 mmu-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000124 mmu-miR-15b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029139 MIMAT0000124 mmu-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000124 mmu-miR-15b miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029140 MIMAT0000124 mmu-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000124 mmu-miR-15b miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029141 MIMAT0000125 mmu-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000125 mmu-miR-23b miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00029142 MIMAT0000125 mmu-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000125 mmu-miR-23b miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029143 MIMAT0000125 mmu-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000125 mmu-miR-23b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029144 MIMAT0000125 mmu-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000125 mmu-miR-23b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029145 MIMAT0000125 mmu-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000125 mmu-miR-23b miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029146 MIMAT0000125 mmu-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000125 mmu-miR-23b miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029147 MIMAT0000126 mmu-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000126 mmu-miR-27b miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029148 MIMAT0000126 mmu-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000126 mmu-miR-27b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029149 MIMAT0000126 mmu-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000126 mmu-miR-27b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029150 MIMAT0000126 mmu-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000126 mmu-miR-27b miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029151 MIMAT0000127 mmu-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000127 mmu-miR-29b miRNA Mus musculus 21862971 Nucleus Liver cell Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029152 MIMAT0000127 mmu-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000127 mmu-miR-29b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029153 MIMAT0000127 mmu-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000127 mmu-miR-29b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029154 MIMAT0000127 mmu-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000127 mmu-miR-29b miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029155 MIMAT0000127 mmu-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000127 mmu-miR-29b miRNA Mus musculus 17204650 Nucleus NIH 3T3 cell Fluorescence in situ hybridization "miR-29b also shows mitotic accumulation and nuclear enrichment in murine NIH 3T3 cells (fig. S6), demonstrating the conservation of this pathway in other mammalian cell lines. " RLID00029156 MIMAT0000127 mmu-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000127 mmu-miR-29b miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00029157 MIMAT0000128 mmu-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000128 "mmu-miR-30a-5p, mmu-miR-30a " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029158 MIMAT0000128 mmu-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000128 "mmu-miR-30a-5p, mmu-miR-30a " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029159 MIMAT0000130 mmu-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000130 mmu-miR-30b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029160 MIMAT0000130 mmu-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000130 mmu-miR-30b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029161 MIMAT0000130 mmu-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000130 mmu-miR-30b miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029162 MIMAT0000130 mmu-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000130 mmu-miR-30b miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00029163 MIMAT0000131 mmu-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000131 mmu-miR-99a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029164 MIMAT0000131 mmu-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000131 mmu-miR-99a miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029165 MIMAT0000131 mmu-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000131 mmu-miR-99a miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029166 MIMAT0000131 mmu-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000131 mmu-miR-99a miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Synaptosomes were extracted with non-ionic detergent and measurements were made of the soluble extract vs. the insoluble residue (i.e., the PSD fraction). As shown in fig.11b, the microRNA precursors were all predominantly associated with the PSD fractionIn contrast, the mature microRNAs were predominantly detected in the Triton-soluble fraction (fig. 7b). Data are collected from Figure 7B.. " RLID00029167 MIMAT0000131 mmu-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000131 mmu-miR-99a miRNA Mus musculus 18410515 Synapse ForeBrain qRT-PCR|Microarray Table 2: Enrichment ratios (synaptoneurosomes/total homogenate) of selected mature microRNAs measured by real-time qRT-PCR. Data are collected from Table 2. RLID00029168 MIMAT0000132 mmu-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000132 mmu-miR-99b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029169 MIMAT0000132 mmu-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000132 mmu-miR-99b miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029170 MIMAT0000133 mmu-miR-101a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000133 mmu-miR-101a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029171 MIMAT0000133 mmu-miR-101a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000133 mmu-miR-101a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029172 MIMAT0000133 mmu-miR-101a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000133 mmu-miR-101a miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00029173 MIMAT0000133 mmu-miR-101a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000133 mmu-miR-101a miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029174 MIMAT0000133 mmu-miR-101a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000133 mmu-miR-101a miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00029175 MIMAT0000134 mmu-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000134 "mmu-miR-124a, mmu-miR-124 " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029176 MIMAT0000134 mmu-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000134 "mmu-miR-124a, mmu-miR-124 " miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "As shown in fig. 6, microRNA precursors were readily detected within the SYN fraction, at levels that were comparable to the total homogenate. Data are collected from Figure 6. " RLID00029177 MIMAT0000134 mmu-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000134 "mmu-miR-124a, mmu-miR-124 " miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Synaptosomes were extracted with non-ionic detergent and measurements were made of the soluble extract vs. the insoluble residue (i.e., the PSD fraction). As shown in fig. 7b, the microRNA precursors were all predominantly associated with the PSD fraction. In contrast, the mature microRNAs were predominantly detected in the Triton-soluble fraction (fig. 7b). Data are collected from Figure 7B. " RLID00029178 MIMAT0000134 mmu-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000134 "mmu-miR-124a, mmu-miR-124 " miRNA Mus musculus 24784359 Dendrite Hippocampus Fluorescence in situ hybridization|qRT-PCR "In contrast, we detected significant concentrations of miR-124 in dendrites. We conclude that GluA2 is a predominantly somatically restricted mRNA, while miR-124 is present in somata and in dendrites. Using these probes, we detected clear dendritic signals for miR-124. Together with the fact that RT-qPCR experiments revealed significant concentrations of miR-124 in synaptosome fractions (Figure 2), our results provide strong evidence that miR-124 is dendritically localized in mouse hippocampal neurons. " RLID00029179 MIMAT0000134 mmu-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000134 "mmu-miR-124a, mmu-miR-124 " miRNA Mus musculus 23897634 Cell body Neuron ball cultures Fluorescence in situ hybridization Data are collected from Table 2: Cell Body-Enriched miRNAs. RLID00029180 MIMAT0000135 mmu-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000135 mmu-miR-125a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029181 MIMAT0000135 mmu-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000135 mmu-miR-125a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029182 MIMAT0000135 mmu-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000135 mmu-miR-125a miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029183 MIMAT0000135 mmu-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000135 mmu-miR-125a miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029184 MIMAT0000135 mmu-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000135 mmu-miR-125a miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00029185 MIMAT0000135 mmu-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000135 mmu-miR-125a miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00029186 MIMAT0000136 mmu-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000136 mmu-miR-125b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029187 MIMAT0000136 mmu-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000136 mmu-miR-125b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029188 MIMAT0000136 mmu-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000136 mmu-miR-125b miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029189 MIMAT0000136 mmu-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000136 mmu-miR-125b miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029190 MIMAT0000136 mmu-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000136 mmu-miR-125b miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "As shown in fig. 6, microRNA precursors were readily detected within the SYN fraction, at levels that were comparable to the total homogenate. Data are collected from Figure 6. " RLID00029191 MIMAT0000136 mmu-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000136 mmu-miR-125b miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Synaptosomes were extracted with non-ionic detergent and measurements were made of the soluble extract vs. the insoluble residue (i.e., the PSD fraction). As shown in fig. 8b, the microRNA precursors were all predominantly associated with the PSD fractionIn contrast, the mature microRNAs were predominantly detected in the Triton-soluble fraction (fig. 7b). Data are collected from Figure 7B.. " RLID00029192 MIMAT0000136 mmu-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000136 mmu-miR-125b miRNA Mus musculus 18410515 Synapse ForeBrain qRT-PCR|Microarray Table 2: Enrichment ratios (synaptoneurosomes/total homogenate) of selected mature microRNAs measured by real-time qRT-PCR. Data are collected from Table 2. RLID00029193 MIMAT0000137 mmu-miR-126a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000137 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029194 MIMAT0000137 mmu-miR-126a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000137 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029195 MIMAT0000137 mmu-miR-126a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000137 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029196 MIMAT0000137 mmu-miR-126a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000137 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00029197 MIMAT0000138 mmu-miR-126a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000138 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029198 MIMAT0000138 mmu-miR-126a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000138 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029199 MIMAT0000138 mmu-miR-126a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000138 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029200 MIMAT0000138 mmu-miR-126a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000138 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00029201 MIMAT0000139 mmu-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000139 mmu-miR-127 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029202 MIMAT0000140 mmu-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000140 "mmu-miR-128a, mmu-miR-128 " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029203 MIMAT0000141 mmu-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000141 mmu-miR-130a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029204 MIMAT0000141 mmu-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000141 mmu-miR-130a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029205 MIMAT0000141 mmu-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000141 mmu-miR-130a miRNA Mus musculus 21862971 Nucleus Liver cell Microarray "Supplementary information, Figure S4 Screening for the target miRNAs of miR-709 in the nucleus via microarray assay (only top 44 miRNAs were showed). Data are collected from Figure S4. " RLID00029206 MIMAT0000141 mmu-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000141 mmu-miR-130a miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029207 MIMAT0000142 mmu-miR-9-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000142 mmu-miR-9 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029208 MIMAT0000142 mmu-miR-9-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000142 mmu-miR-9 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029209 MIMAT0000143 mmu-miR-9-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000143 mmu-miR-9* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029210 MIMAT0000143 mmu-miR-9-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000143 mmu-miR-9* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029211 MIMAT0000143 mmu-miR-9-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000143 mmu-miR-9* miRNA Mus musculus 23897634 Cell body Neuron ball cultures Fluorescence in situ hybridization Data are collected from Table 2: Cell Body-Enriched miRNAs. RLID00029212 MIMAT0000144 mmu-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000144 mmu-miR-132 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029213 MIMAT0000144 mmu-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000144 mmu-miR-132 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029214 MIMAT0000144 mmu-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000144 mmu-miR-132 miRNA Mus musculus 24381269 Axon Dorsal root ganglion qRT-PCR "High axonal expression and preferential localization were observed for miR-132, a miRNA previously known for roles in dendrites and dysregulation in major neurologic diseases. miR-132 knockdown reduced extension of cultured DRG axons, whereas overexpression increased extension. " RLID00029215 MIMAT0000144 mmu-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000144 mmu-miR-132 miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00029216 MIMAT0000144 mmu-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000144 mmu-miR-132 miRNA Mus musculus 20506192 Dendrite Hippocampal neuroprogenitors In situ hybridization "Several miRNAs are found to be localized and functioning in dendrites and synapses. Among them, miR-132 and miR-137 are both enriched in dendritic spines, but whereas miR-132 represses spine volume, miR-137 shows no effect on spine volume. " RLID00029217 MIMAT0000145 mmu-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000145 mmu-miR-133a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029218 MIMAT0000146 mmu-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000146 mmu-miR-134 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029219 MIMAT0000146 mmu-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000146 mmu-miR-134 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00029220 MIMAT0000146 mmu-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000146 mmu-miR-134 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "As shown in fig. 6, microRNA precursors were readily detected within the SYN fraction, at levels that were comparable to the total homogenate. Data are collected from Figure 6. " RLID00029221 MIMAT0000146 mmu-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000146 mmu-miR-134 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Synaptosomes were extracted with non-ionic detergent and measurements were made of the soluble extract vs. the insoluble residue (i.e., the PSD fraction). As shown in fig. 9b, the microRNA precursors were all predominantly associated with the PSD fractionIn contrast, the mature microRNAs were predominantly detected in the Triton-soluble fraction (fig. 7b). Data are collected from Figure 7B.. " RLID00029222 MIMAT0000146 mmu-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000146 mmu-miR-134 miRNA Mus musculus 23897634 Synapse Neuron ball cultures Fluorescence in situ hybridization "Moreover, of these 12 miRNAs, six were significantly enriched in axons when compared with the mean cell body–axon gradient calculated from all miRNAs (Table 1). miR-134, which was reported to be enriched in synapses (Schratt et al., 2006), and detected in axonal growth cones by FISH (Han et al., 2011) was also enriched in axons in our preparation, although the Ct value of cell bodies was below our cutoff value (i.e., 33; Table 1). " RLID00029223 MIMAT0000146 mmu-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000146 mmu-miR-134 miRNA Mus musculus 23897634 Axon Neuron ball cultures Fluorescence in situ hybridization "Moreover, of these 12 miRNAs, six were significantly enriched in axons when compared with the mean cell body–axon gradient calculated from all miRNAs (Table 1). miR-134, which was reported to be enriched in synapses (Schratt et al., 2006), and detected in axonal growth cones by FISH (Han et al., 2011) was also enriched in axons in our preparation, although the Ct value of cell bodies was below our cutoff value (i.e., 33; Table 1). " RLID00029224 MIMAT0000146 mmu-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000146 mmu-miR-134 miRNA Mus musculus 24874920 Dendrite Hippocampus In situ hybridization "MicroRNA-134 (miR-134) is enriched in dendrites of hippocampal neurons, where it negatively regulates spine volume. Recent work identified upregulation of miR-134 in experimental and human epilepsy. " RLID00029225 MIMAT0000146 mmu-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000146 mmu-miR-134 miRNA Mus musculus 18410515 Synapse ForeBrain qRT-PCR|Microarray Table 2: Enrichment ratios (synaptoneurosomes/total homogenate) of selected mature microRNAs measured by real-time qRT-PCR. Data are collected from Table 2. RLID00029226 MIMAT0000147 mmu-miR-135a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000147 mmu-miR-135a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029227 MIMAT0000147 mmu-miR-135a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000147 mmu-miR-135a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029228 MIMAT0000147 mmu-miR-135a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000147 mmu-miR-135a miRNA Mus musculus 23897634 Cell body Neuron ball cultures Fluorescence in situ hybridization Data are collected from Table 2: Cell Body-Enriched miRNAs. RLID00029229 MIMAT0000148 mmu-miR-136-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000148 mmu-miR-136 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029230 MIMAT0000149 mmu-miR-137-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000149 mmu-miR-137 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029231 MIMAT0000149 mmu-miR-137-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000149 mmu-miR-137 miRNA Mus musculus 20506192 Dendrite Hippocampal neuroprogenitors In situ hybridization "Several miRNAs are found to be localized and functioning in dendrites and synapses. Among them, miR-132 and miR-137 are both enriched in dendritic spines, but whereas miR-132 represses spine volume, miR-137 shows no effect on spine volume. " RLID00029232 MIMAT0000149 mmu-miR-137-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000149 mmu-miR-137 miRNA Mus musculus 23897634 Cell body Neuron ball cultures Fluorescence in situ hybridization Data are collected from Table 2: Cell Body-Enriched miRNAs. RLID00029233 MIMAT0000150 mmu-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000150 mmu-miR-138 miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00029234 MIMAT0000150 mmu-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000150 mmu-miR-138 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029235 MIMAT0000150 mmu-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000150 mmu-miR-138 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029236 MIMAT0000150 mmu-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000150 mmu-miR-138 miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00029237 MIMAT0000151 mmu-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000151 mmu-miR-140 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029238 MIMAT0000151 mmu-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000151 mmu-miR-140 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029239 MIMAT0000152 mmu-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000152 mmu-miR-140* miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00029240 MIMAT0000152 mmu-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000152 mmu-miR-140* miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029241 MIMAT0000152 mmu-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000152 mmu-miR-140* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029242 MIMAT0000152 mmu-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000152 mmu-miR-140* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029243 MIMAT0000154 mmu-miR-142a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000154 mmu-miR-142-5p miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00029244 MIMAT0000154 mmu-miR-142a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000154 mmu-miR-142-5p miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029245 MIMAT0000154 mmu-miR-142a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000154 mmu-miR-142-5p miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029246 MIMAT0000154 mmu-miR-142a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000154 mmu-miR-142-5p miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029247 MIMAT0000154 mmu-miR-142a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000154 mmu-miR-142-5p miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029248 MIMAT0000154 mmu-miR-142a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000154 mmu-miR-142-5p miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00029249 MIMAT0000155 mmu-miR-142a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000155 mmu-miR-142-3p miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029250 MIMAT0000155 mmu-miR-142a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000155 mmu-miR-142-3p miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029251 MIMAT0000155 mmu-miR-142a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000155 mmu-miR-142-3p miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029252 MIMAT0000155 mmu-miR-142a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000155 mmu-miR-142-3p miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029253 MIMAT0000155 mmu-miR-142a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000155 mmu-miR-142-3p miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00029254 MIMAT0000156 mmu-miR-144-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000156 mmu-miR-144 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029255 MIMAT0000157 mmu-miR-145a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000157 "mmu-miR-145, mmu-miR-145-5p " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029256 MIMAT0000157 mmu-miR-145a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000157 "mmu-miR-145, mmu-miR-145-5p " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029257 MIMAT0000157 mmu-miR-145a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000157 "mmu-miR-145, mmu-miR-145-5p " miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029258 MIMAT0000157 mmu-miR-145a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000157 "mmu-miR-145, mmu-miR-145-5p " miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00029259 MIMAT0000158 mmu-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000158 "mmu-miR-146, mmu-miR-146a " miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00029260 MIMAT0000158 mmu-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000158 "mmu-miR-146, mmu-miR-146a " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029261 MIMAT0000158 mmu-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000158 "mmu-miR-146, mmu-miR-146a " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029262 MIMAT0000158 mmu-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000158 "mmu-miR-146, mmu-miR-146a " miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00029263 MIMAT0000158 mmu-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000158 "mmu-miR-146, mmu-miR-146a " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029264 MIMAT0000158 mmu-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000158 "mmu-miR-146, mmu-miR-146a " miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00029265 MIMAT0000158 mmu-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000158 "mmu-miR-146, mmu-miR-146a " miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00029266 MIMAT0000159 mmu-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000159 mmu-miR-149 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029267 MIMAT0000159 mmu-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000159 mmu-miR-149 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029268 MIMAT0000160 mmu-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000160 mmu-miR-150 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029269 MIMAT0000160 mmu-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000160 mmu-miR-150 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029270 MIMAT0000160 mmu-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000160 mmu-miR-150 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029271 MIMAT0000160 mmu-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000160 mmu-miR-150 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029272 MIMAT0000160 mmu-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000160 mmu-miR-150 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00029273 MIMAT0000161 mmu-miR-151-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000161 mmu-miR-151 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029274 MIMAT0000161 mmu-miR-151-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000161 mmu-miR-151 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029275 MIMAT0000162 mmu-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000162 mmu-miR-152 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029276 MIMAT0000162 mmu-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000162 mmu-miR-152 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029277 MIMAT0000162 mmu-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000162 mmu-miR-152 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029278 MIMAT0000163 mmu-miR-153-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000163 mmu-miR-153 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00029279 MIMAT0000164 mmu-miR-154-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000164 mmu-miR-154 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029280 MIMAT0000165 mmu-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000165 mmu-miR-155 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029281 MIMAT0000165 mmu-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000165 mmu-miR-155 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029282 MIMAT0000165 mmu-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000165 mmu-miR-155 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00029283 MIMAT0000209 mmu-miR-129-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000209 mmu-miR-129 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029284 MIMAT0000209 mmu-miR-129-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000209 mmu-miR-129 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029285 MIMAT0000210 mmu-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000210 mmu-miR-181a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029286 MIMAT0000210 mmu-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000210 mmu-miR-181a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029287 MIMAT0000210 mmu-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000210 mmu-miR-181a miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029288 MIMAT0000211 mmu-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000211 mmu-miR-182 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029289 MIMAT0000211 mmu-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000211 mmu-miR-182 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029290 MIMAT0000211 mmu-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000211 mmu-miR-182 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029291 MIMAT0000211 mmu-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000211 mmu-miR-182 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029292 MIMAT0000211 mmu-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000211 mmu-miR-182 miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00029293 MIMAT0000211 mmu-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000211 mmu-miR-182 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00029294 MIMAT0000212 mmu-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000212 mmu-miR-183 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029295 MIMAT0000212 mmu-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000212 mmu-miR-183 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029296 MIMAT0000212 mmu-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000212 mmu-miR-183 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00029297 MIMAT0000213 mmu-miR-184-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000213 mmu-miR-184 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029298 MIMAT0000213 mmu-miR-184-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000213 mmu-miR-184 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029299 MIMAT0000213 mmu-miR-184-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000213 mmu-miR-184 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029300 MIMAT0000214 mmu-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000214 mmu-miR-185 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029301 MIMAT0000214 mmu-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000214 mmu-miR-185 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029302 MIMAT0000214 mmu-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000214 mmu-miR-185 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029303 MIMAT0000214 mmu-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000214 mmu-miR-185 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029304 MIMAT0000214 mmu-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000214 mmu-miR-185 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029305 MIMAT0000215 mmu-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000215 mmu-miR-186 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029306 MIMAT0000216 mmu-miR-187-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000216 mmu-miR-187 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029307 MIMAT0000216 mmu-miR-187-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000216 mmu-miR-187 miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00029308 MIMAT0000216 mmu-miR-187-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000216 mmu-miR-187 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029309 MIMAT0000217 mmu-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000217 mmu-miR-188 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029310 MIMAT0000217 mmu-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000217 mmu-miR-188 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029311 MIMAT0000217 mmu-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000217 mmu-miR-188 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00029312 MIMAT0000217 mmu-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000217 mmu-miR-188 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029313 MIMAT0000217 mmu-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000217 mmu-miR-188 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029314 MIMAT0000217 mmu-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000217 mmu-miR-188 miRNA Mus musculus 23897634 Cell body Neuron ball cultures Fluorescence in situ hybridization Data are collected from Table 2: Cell Body-Enriched miRNAs. RLID00029315 MIMAT0000219 mmu-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000219 mmu-miR-24 miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00029316 MIMAT0000219 mmu-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000219 mmu-miR-24 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029317 MIMAT0000219 mmu-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000219 mmu-miR-24 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029318 MIMAT0000219 mmu-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000219 mmu-miR-24 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029319 MIMAT0000219 mmu-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000219 mmu-miR-24 miRNA Mus musculus 18204908 Nucleolus Spermatocyte In situ hybridization|Microarray "Hybridization signals with all miRNA probes tested localized to the Sertoli cells (Figure 5A), with some also present in the cytoplasm of the germ cells (miR-214) and others (miR-24) having a distinct localization pattern in the nuclei of spermatocytes (Figure 5A). " RLID00029320 MIMAT0000219 mmu-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000219 mmu-miR-24 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029321 MIMAT0000219 mmu-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000219 mmu-miR-24 miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00029322 MIMAT0000220 mmu-miR-190a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000220 "mmu-miR-190, mmu-miR-190-5p " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029323 MIMAT0000220 mmu-miR-190a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000220 "mmu-miR-190, mmu-miR-190-5p " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029324 MIMAT0000221 mmu-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000221 mmu-miR-191 miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00029325 MIMAT0000221 mmu-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000221 mmu-miR-191 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029326 MIMAT0000221 mmu-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000221 mmu-miR-191 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029327 MIMAT0000221 mmu-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000221 mmu-miR-191 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029328 MIMAT0000221 mmu-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000221 mmu-miR-191 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029329 MIMAT0000221 mmu-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000221 mmu-miR-191 miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00029330 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 22105822 Circulating plasma qRT-PCR "Our study revealed that plasma miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a, and miR-801 were potential circulating markers for diagnosing HCC. The microRNA panel with the seven microRNAs from the multivariate logistic regression model demonstrated high accuracy in the diagnosis of HCC, especially for patients with early BCLC stages (0 and A). " RLID00029331 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029332 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029333 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029334 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 24981880 Circulating Serum qRT-PCR "Results from recent studies revealed that circulating miRNAs are also potential diagnostic biomarkers and prognostic factors in diabetes. The results of qRT-PCR assessment revealed low serum levels of miR-23a, let-7i, miR-486, miR-96, miR-186, miR-191, miR-192, and miR-146a in T2D. " RLID00029335 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00029336 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 25405200 Circulating Serum qRT-PCR "Individual qRT-PCR results (expression level) of serum miRNA expression in macrosomia and controls is shown in Table 3, including has-miR-122, has-miR-192, has-miR-194, has-miR-296-5p, has-miR-376a, has-miR-487b, has-miR-505, has-miR-1262 " RLID00029337 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029338 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00029339 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029340 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 19289371 Exosome Plasma Microarray Figure 1: Intensities for specific microRNAs derived from the tumor and exosomes isolated from the plasma of the patients. Data are collected from Figure 1. RLID00029341 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029342 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 22895844 Exosome Colon|Liver|Lung qRT-PCR "When the RNA species within exosomes derived from the three CRC cell lines were examined, the mRNAs of housekeeping genes such as ACTB and GAPDH, the microRNAs such as miR-21, miR-192 and miR-221, and the natural antisense RNAs of LRRC24, MDM2 and CDKN1A genes, were detected. " RLID00029343 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029344 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029345 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00029346 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029347 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029348 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029349 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029350 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029351 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029352 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 25238238 Circulating Serum qRT-PCR "Our study revealed that serum hsa-miR-206, hsa-miR-141-3p, hsa-miR-433-3p, hsa-miR-1228-5p, hsa-miR-199a-5p, hsa-miR-122-5p, hsa-miR-192-5p, and hsa-miR-26a-5p were potential circulating markers for HCC diagnosis. " RLID00029353 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029354 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029355 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029356 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029357 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00029358 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029359 MIMAT0000222 hsa-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000222 hsa-miR-192 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029360 MIMAT0000223 mmu-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000223 "mmu-miR-193, mmu-miR-193-3p " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029361 MIMAT0000224 mmu-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000224 mmu-miR-194 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029362 MIMAT0000224 mmu-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000224 mmu-miR-194 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029363 MIMAT0000224 mmu-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000224 mmu-miR-194 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00029364 MIMAT0000224 mmu-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000224 mmu-miR-194 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029365 MIMAT0000225 mmu-miR-195a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000225 "mmu-miR-195, mmu-miR-195-5p " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029366 MIMAT0000225 mmu-miR-195a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000225 "mmu-miR-195, mmu-miR-195-5p " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029367 MIMAT0000225 mmu-miR-195a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000225 "mmu-miR-195, mmu-miR-195-5p " miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029368 MIMAT0000225 mmu-miR-195a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000225 "mmu-miR-195, mmu-miR-195-5p " miRNA Mus musculus 23897634 Cell body Neuron ball cultures Fluorescence in situ hybridization Data are collected from Table 2: Cell Body-Enriched miRNAs. RLID00029369 MIMAT0000226 hsa-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000226 hsa-miR-196a miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00029370 MIMAT0000226 hsa-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000226 hsa-miR-196a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029371 MIMAT0000226 hsa-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000226 hsa-miR-196a miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029372 MIMAT0000226 hsa-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000226 hsa-miR-196a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029373 MIMAT0000226 hsa-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000226 hsa-miR-196a miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00029374 MIMAT0000226 hsa-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000226 hsa-miR-196a miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029375 MIMAT0000226 hsa-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000226 hsa-miR-196a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029376 MIMAT0000226 hsa-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000226 hsa-miR-196a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029377 MIMAT0000226 hsa-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000226 hsa-miR-196a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029378 MIMAT0000226 hsa-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000226 hsa-miR-196a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029379 MIMAT0000226 hsa-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000226 hsa-miR-196a miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029380 MIMAT0000226 hsa-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000226 hsa-miR-196a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029381 MIMAT0000226 hsa-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000226 hsa-miR-196a miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00029382 MIMAT0000226 hsa-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000226 hsa-miR-196a miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00029383 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00029384 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029385 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029386 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029387 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029388 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00029389 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029390 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029391 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029392 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029393 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029394 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 23559272 Circulating Serum Microarray "Using microarray-based expression profiling followed by real-time quantitative polymerase chain reaction validation, we compared the levels of a series of circulating miRNAs (miR-21, miR-155, miR-182, and miR-197) in serum from patients with lung cancer (n = 65), pulmonary tuberculosis (n = 29), pneumonia (n = 29), and transudate (n = 16) compared with matched healthy controls (n = 37). " RLID00029395 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029396 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00029397 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029398 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029399 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029400 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00029401 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029402 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00029403 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029404 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029405 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029406 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029407 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029408 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029409 MIMAT0000227 hsa-miR-197-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000227 hsa-miR-197 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029410 MIMAT0000228 hsa-miR-198 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000228 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029411 MIMAT0000228 hsa-miR-198 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000228 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029412 MIMAT0000228 hsa-miR-198 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000228 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029413 MIMAT0000228 hsa-miR-198 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000228 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029414 MIMAT0000228 hsa-miR-198 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000228 miRNA Homo sapiens 24468161 Exosome Breast cancer cell RT-PCR|Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00029415 MIMAT0000228 hsa-miR-198 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000228 miRNA Homo sapiens 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00029416 MIMAT0000228 hsa-miR-198 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000228 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00029417 MIMAT0000230 mmu-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000230 mmu-miR-199a* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029418 MIMAT0000231 hsa-miR-199a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000231 hsa-miR-199a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029419 MIMAT0000231 hsa-miR-199a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000231 hsa-miR-199a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029420 MIMAT0000231 hsa-miR-199a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000231 hsa-miR-199a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029421 MIMAT0000231 hsa-miR-199a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000231 hsa-miR-199a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029422 MIMAT0000231 hsa-miR-199a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000231 hsa-miR-199a miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029423 MIMAT0000231 hsa-miR-199a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000231 hsa-miR-199a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029424 MIMAT0000231 hsa-miR-199a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000231 hsa-miR-199a miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00029425 MIMAT0000231 hsa-miR-199a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000231 hsa-miR-199a miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00029426 MIMAT0000231 hsa-miR-199a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000231 hsa-miR-199a miRNA Homo sapiens 25238238 Circulating Serum qRT-PCR "Our study revealed that serum hsa-miR-206, hsa-miR-141-3p, hsa-miR-433-3p, hsa-miR-1228-5p, hsa-miR-199a-5p, hsa-miR-122-5p, hsa-miR-192-5p, and hsa-miR-26a-5p were potential circulating markers for HCC diagnosis. " RLID00029427 MIMAT0000231 hsa-miR-199a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000231 hsa-miR-199a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029428 MIMAT0000231 hsa-miR-199a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000231 hsa-miR-199a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029429 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029430 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029431 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029432 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029433 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029434 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00029435 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00029436 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029437 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029438 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029439 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00029440 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029441 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029442 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029443 MIMAT0000232 hsa-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000232 hsa-miR-199a* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029444 MIMAT0000233 mmu-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000233 mmu-miR-200b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029445 MIMAT0000233 mmu-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000233 mmu-miR-200b miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00029446 MIMAT0000235 mmu-miR-202-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000235 mmu-miR-202 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029447 MIMAT0000235 mmu-miR-202-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000235 mmu-miR-202 miRNA Mus musculus 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00029448 MIMAT0000235 mmu-miR-202-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000235 mmu-miR-202 miRNA Mus musculus 18204908 Nucleolus Spermatocyte In situ hybridization|Microarray "This round mass contained little DNA and appeared in the surrounding DNA as a darker structure resembling the nucleolus (Thiry 1993). Other miRNAs tested miR-320, 20 and 202 exhibited similar patterns except that miR-320 localized to the Sertoli cell nucleolus and also displayed a diffuse pattern in the nucleus but not in the cytoplasm of germ cells (data not shown). " RLID00029449 MIMAT0000236 mmu-miR-203-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000236 mmu-miR-203 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029450 MIMAT0000236 mmu-miR-203-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000236 mmu-miR-203 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029451 MIMAT0000237 mmu-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000237 mmu-miR-204 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029452 MIMAT0000239 mmu-miR-206-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000239 mmu-miR-206 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029453 MIMAT0000240 mmu-miR-207 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000240 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00029454 MIMAT0000241 hsa-miR-208a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000241 hsa-miR-208 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029455 MIMAT0000241 hsa-miR-208a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000241 hsa-miR-208 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029456 MIMAT0000242 hsa-miR-129-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000242 hsa-miR-129 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029457 MIMAT0000242 hsa-miR-129-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000242 hsa-miR-129 miRNA Homo sapiens 24456939 Circulating Gastric juice - "In gastric cancer, several circulating miRNAs have been studied as potential diagnostic biomarkers by evaluating their amount in serum, plasma and gastric juice (Table 2). Data are collected from Table 2. " RLID00029458 MIMAT0000242 hsa-miR-129-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000242 hsa-miR-129 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029459 MIMAT0000242 hsa-miR-129-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000242 hsa-miR-129 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029460 MIMAT0000242 hsa-miR-129-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000242 hsa-miR-129 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029461 MIMAT0000242 hsa-miR-129-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000242 hsa-miR-129 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029462 MIMAT0000242 hsa-miR-129-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000242 hsa-miR-129 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00029463 MIMAT0000242 hsa-miR-129-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000242 hsa-miR-129 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029464 MIMAT0000242 hsa-miR-129-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000242 hsa-miR-129 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00029465 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029466 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029467 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029468 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00029469 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029470 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00029471 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029472 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029473 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029474 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00029475 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029476 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029477 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00029478 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029479 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00029480 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029481 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029482 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029483 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029484 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00029485 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029486 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029487 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029488 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029489 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 25376581 Exosome Saliva RNA-seq "Previous reports suggested that the majority of miRNAs in saliva were concentrated in exosomes. We tested the presence of miRNAs in exosome and nonexosome fractions of saliva in a subset of samples (Fig. 1C; online Supplemental Fig. 4). Two miRNAs (miR-223-3p and miR-148a-3p) detected in RNA-Seq data of multiple individuals were chosen for this experiment. As shown in Fig. 1C, both miRNAs can be detected in all 3 individuals, and they are predominantly present in the exosomal RNA fraction in 2 of 3 individuals. For 1 individual (S1), both miRNAs were detected in both exosomal and nonexosomal fractions. " RLID00029490 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029491 MIMAT0000243 hsa-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000243 hsa-miR-148a miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00029492 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00029493 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029494 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029495 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029496 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00029497 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029498 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00029499 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029500 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029501 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029502 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029503 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00029504 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029505 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029506 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029507 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029508 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029509 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00029510 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00029511 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029512 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029513 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029514 MIMAT0000244 hsa-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000244 hsa-miR-30c miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029515 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 20194856 Circulating Serum Next-generation sequencing "Endogenous circulating miRNAs are stable, are well protected from RNases, and remain stable even after being subjected to harsh conditions. Eleven serum miRNAs were found to be altered more than five-fold by Solexa sequencing between longer-survival and shorter-survival groups, and levels of four miRNAs (ie, miR-486, miR-30d, miR-1 and miR-501) were significantly associated with overall survival. " RLID00029516 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029517 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029518 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029519 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029520 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00029521 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029522 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00029523 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029524 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029525 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029526 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029527 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00029528 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00029529 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029530 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029531 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In contrast to oncomirs, an miRNA that is involved in tumor-suppressing activities, is taken as a tumor suppressor (oncosuppressor). The aberrantly expressed miR-223, which directly targeted Stathmin 1 to inhibit HCC growth, was only found in MVs of liver cancer cell line in our study (table 2). Data are collected from Table 2. " RLID00029532 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029533 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029534 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029535 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029536 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00029537 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00029538 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029539 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029540 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029541 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00029542 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00029543 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029544 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029545 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 22529849 Exosome Liver carcinoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029546 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029547 MIMAT0000245 hsa-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000245 hsa-miR-30d miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00029548 MIMAT0000246 mmu-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000246 "mmu-miR-122a, mmu-miR-122 " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029549 MIMAT0000246 mmu-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000246 "mmu-miR-122a, mmu-miR-122 " miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00029550 MIMAT0000246 mmu-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000246 "mmu-miR-122a, mmu-miR-122 " miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029551 MIMAT0000247 mmu-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000247 mmu-miR-143 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029552 MIMAT0000247 mmu-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000247 mmu-miR-143 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029553 MIMAT0000247 mmu-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000247 mmu-miR-143 miRNA Mus musculus 18410515 Synapse ForeBrain qRT-PCR|Microarray Table 2: Enrichment ratios (synaptoneurosomes/total homogenate) of selected mature microRNAs measured by real-time qRT-PCR. Data are collected from Table 2. RLID00029554 MIMAT0000247 mmu-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000247 mmu-miR-143 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00029555 MIMAT0000248 mmu-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000248 mmu-miR-30e miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029556 MIMAT0000248 mmu-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000248 mmu-miR-30e miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00029557 MIMAT0000248 mmu-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000248 mmu-miR-30e miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00029558 MIMAT0000248 mmu-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000248 mmu-miR-30e miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00029559 MIMAT0000249 mmu-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000249 mmu-miR-30e* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00029560 MIMAT0000250 hsa-miR-139-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000250 hsa-miR-139 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029561 MIMAT0000250 hsa-miR-139-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000250 hsa-miR-139 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029562 MIMAT0000250 hsa-miR-139-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000250 hsa-miR-139 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029563 MIMAT0000250 hsa-miR-139-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000250 hsa-miR-139 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029564 MIMAT0000250 hsa-miR-139-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000250 hsa-miR-139 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029565 MIMAT0000250 hsa-miR-139-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000250 hsa-miR-139 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029566 MIMAT0000250 hsa-miR-139-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000250 hsa-miR-139 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00029567 MIMAT0000251 hsa-miR-147a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000251 hsa-miR-147 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029568 MIMAT0000251 hsa-miR-147a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000251 hsa-miR-147 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029569 MIMAT0000251 hsa-miR-147a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000251 hsa-miR-147 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029570 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00029571 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029572 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029573 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029574 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029575 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00029576 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029577 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029578 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029579 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029580 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00029581 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029582 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029583 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029584 MIMAT0000252 hsa-miR-7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000252 hsa-miR-7 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029585 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 20145944 Circulating Semen RT-PCR|Microarray "Our results highlight four miRNA markers for blood identification (miR-20a, miR-106a, miR-185, and miR-144) and five for semen identification (miR-135a, miR-10a, miR-507, miR-943, and miR-891a). Of those, two miRNA markers for blood (miR-144 and miR-185) and two others for semen (miR-135a and miR-897a) are suggestive to be most useful for body fluid identification in future forensic applications, and the respective RT-PCR assays used here for their detection were highly sensitive, allowing the reliable marker detection from subpicogram amounts of total RNA. Our results proved the applicability of the miRNA approach for forensic body fluids identification. " RLID00029586 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 21098710 Circulating Serum qRT-PCR "By selecting miRNAs that have 3-fold higher expression in HBV compared with control serum, we identified total of 13 upregulated miRNAs, including miR-375, miR-92a, miR-10a, miR-223, miR-423, miR-23b/a, miR-342-3p, miR-99a, miR-122a, miR-125b, miR-150, and let-7c. As shown in Figure 2, the upregulation of these 13 miRNA expressions in the serum of HBV cases, compared with those of controls, was largely consistent when detected by Solexa in pooled samples and qRT-PCR in individual samples. Data are collected from Figure 2. " RLID00029587 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029588 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029589 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029590 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029591 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00029592 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029593 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029594 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029595 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00029596 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029597 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00029598 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029599 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029600 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029601 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00029602 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029603 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00029604 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00029605 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00029606 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00029607 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029608 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029609 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029610 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029611 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00029612 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029613 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029614 MIMAT0000253 hsa-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000253 hsa-miR-10a miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00029615 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 21398193 Circulating Blood qRT-PCR "Figure 3: Elevated levels of RNA and miRs in blood of lung cancer patients. The box plot shows the significantly different amounts of RNA, miR10b, miR34a, miR141 and miR155 which circulate in blood of healthy individuals (n = 28), patients with benign lung disease (n = 7) and patients with lung cancer (n = 35). " RLID00029616 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029617 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029618 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029619 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00029620 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029621 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029622 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029623 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029624 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029625 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00029626 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029627 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029628 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029629 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00029630 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00029631 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00029632 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00029633 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00029634 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029635 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029636 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029637 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029638 MIMAT0000254 hsa-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000254 hsa-miR-10b miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00029639 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 21398193 Circulating Blood qRT-PCR "Figure 3: Elevated levels of RNA and miRs in blood of lung cancer patients. The box plot shows the significantly different amounts of RNA, miR10b, miR34a, miR141 and miR155 which circulate in blood of healthy individuals (n = 28), patients with benign lung disease (n = 7) and patients with lung cancer (n = 35). " RLID00029640 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029641 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 24456939 Circulating Serum - "In gastric cancer, several circulating miRNAs have been studied as potential diagnostic biomarkers by evaluating their amount in serum, plasma and gastric juice (Table 2). Data are collected from Table 2. " RLID00029642 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00029643 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029644 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029645 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00029646 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029647 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029648 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029649 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00029650 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029651 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029652 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029653 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029654 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029655 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029656 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029657 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029658 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029659 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 24865854 Circulating Plasma qRT-PCR|Next-generation sequcencing "Further exploration of their levels in the plasma of CAD patient and control cases, only circulating miR-361-5p and miR-484 were more abundant in CAD cases by RT-qPCR (Fig. 2D). Levels of circulating miR-140-5p showed no different between healthy and disease population (Fig. 2D). Moreover, levels of miR-342-3p, miR-125b-5p, miR-34a-5p, miR-103a-3p, and miR-125a-5p were even reduced significantly in patient circulation (Fig. 2D). " RLID00029660 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00029661 MIMAT0000255 hsa-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000255 hsa-miR-34a miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00029662 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 23424776 Circulating Blood qRT-PCR|Microarray "Five miRNAs (let-7c, miR-16, miR- 449, miR-181a and miR-181b) were found to exhibit similar expression patterns (p < 0.05) in peripheral blood when compared to data obtained by using bone marrow aspirates from MM patients in other studies. " RLID00029663 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029664 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029665 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029666 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029667 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00029668 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029669 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029670 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029671 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00029672 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029673 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029674 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029675 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029676 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029677 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029678 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00029679 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029680 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029681 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029682 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029683 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00029684 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029685 MIMAT0000256 hsa-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000256 hsa-miR-181a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029686 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 22094284 Circulating serum qRT-PCR|RNA-seq "When compared with family schizophrenia patients, circulating miR-219-2-3p, miR-92a, miR-346, let-7g and miR-17 were significantly higher in sporadic schizophrenia ( p < 0.001, Fig. 4 ). On contrary, miR-181b and miR-195 were significantlydown-regulated in sporadic schizophrenia compared with family schizophrenia patients ( p < 0.001), miR-1308 was slightly lower in sporadic schizophrenia compared family schizophrenia patients (0.05 < p < 0.001), and miR-103 was highly consistent between sporadic schizophrenia and family schizophrenia patients ( p > 0.05). These data indicate that there is a close relationship between levels of circulating miRNAs and schizophrenia patients whether they have the family history or not. " RLID00029687 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 23424776 Circulating Blood qRT-PCR|Microarray "Five miRNAs (let-7c, miR-16, miR- 449, miR-181a and miR-181b) were found to exhibit similar expression patterns (p < 0.05) in peripheral blood when compared to data obtained by using bone marrow aspirates from MM patients in other studies. " RLID00029688 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029689 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029690 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029691 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 23805240 Circulating Plasma qRT-PCR "Circulating microRNAs as a Fingerprint for Liver Cirrhosis. Our study demonstrated that the combined detection of miR-106b and miR-181b has a considerable clinical value to diagnose patients with liver cirrhosis, especially those at early stage. " RLID00029692 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 25126405 Circulating Serum qRT-PCR "Circulating miRNAs in the serum and plasma are remarkably stable and are suggested to have promise as noninvasive biomarkers for neurological and neurodevelopmental disorders. Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated. " RLID00029693 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029694 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029695 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029696 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029697 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029698 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029699 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00029700 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In contrast to oncomirs, an miRNA that is involved in tumor-suppressing activities, is taken as a tumor suppressor (oncosuppressor). The aberrantly expressed miR-223, which directly targeted Stathmin 1 to inhibit HCC growth, was only found in MVs of liver cancer cell line in our study (table 2). Data are collected from Table 2. " RLID00029701 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029702 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029703 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029704 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029705 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029706 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00029707 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029708 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029709 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029710 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029711 MIMAT0000257 hsa-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000257 hsa-miR-181b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029712 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029713 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029714 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029715 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029716 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029717 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029718 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029719 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029720 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029721 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029722 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00029723 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00029724 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029725 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00029726 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029727 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029728 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00029729 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00029730 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029731 MIMAT0000258 hsa-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000258 hsa-miR-181c miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029732 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029733 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029734 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029735 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029736 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00029737 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029738 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00029739 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029740 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00029741 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029742 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029743 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 23559272 Circulating Serum Microarray "Using microarray-based expression profiling followed by real-time quantitative polymerase chain reaction validation, we compared the levels of a series of circulating miRNAs (miR-21, miR-155, miR-182, and miR-197) in serum from patients with lung cancer (n = 65), pulmonary tuberculosis (n = 29), pneumonia (n = 29), and transudate (n = 16) compared with matched healthy controls (n = 37). " RLID00029744 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029745 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029746 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029747 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029748 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029749 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00029750 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029751 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00029752 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00029753 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029754 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029755 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029756 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029757 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00029758 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029759 MIMAT0000259 hsa-miR-182-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000259 hsa-miR-182 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029760 MIMAT0000260 hsa-miR-182-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000260 hsa-miR-182* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00029761 MIMAT0000260 hsa-miR-182-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000260 hsa-miR-182* miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00029762 MIMAT0000260 hsa-miR-182-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000260 hsa-miR-182* miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00029763 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00029764 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029765 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029766 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029767 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029768 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00029769 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029770 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00029771 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029772 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00029773 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029774 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029775 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00029776 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029777 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029778 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029779 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00029780 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029781 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029782 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029783 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029784 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029785 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029786 MIMAT0000261 hsa-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000261 hsa-miR-183 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029787 MIMAT0000262 hsa-miR-187-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000262 hsa-miR-187 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029788 MIMAT0000262 hsa-miR-187-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000262 hsa-miR-187 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00029789 MIMAT0000262 hsa-miR-187-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000262 hsa-miR-187 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029790 MIMAT0000262 hsa-miR-187-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000262 hsa-miR-187 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029791 MIMAT0000262 hsa-miR-187-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000262 hsa-miR-187 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029792 MIMAT0000262 hsa-miR-187-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000262 hsa-miR-187 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029793 MIMAT0000262 hsa-miR-187-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000262 hsa-miR-187 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029794 MIMAT0000262 hsa-miR-187-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000262 hsa-miR-187 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029795 MIMAT0000263 hsa-miR-199b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000263 hsa-miR-199b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029796 MIMAT0000263 hsa-miR-199b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000263 hsa-miR-199b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029797 MIMAT0000263 hsa-miR-199b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000263 hsa-miR-199b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029798 MIMAT0000263 hsa-miR-199b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000263 hsa-miR-199b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029799 MIMAT0000263 hsa-miR-199b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000263 hsa-miR-199b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029800 MIMAT0000263 hsa-miR-199b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000263 hsa-miR-199b miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00029801 MIMAT0000263 hsa-miR-199b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000263 hsa-miR-199b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029802 MIMAT0000263 hsa-miR-199b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000263 hsa-miR-199b miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00029803 MIMAT0000263 hsa-miR-199b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000263 hsa-miR-199b miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00029804 MIMAT0000263 hsa-miR-199b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000263 hsa-miR-199b miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00029805 MIMAT0000263 hsa-miR-199b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000263 hsa-miR-199b miRNA Homo sapiens 22529849 Exosome Liver carcinoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029806 MIMAT0000263 hsa-miR-199b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000263 hsa-miR-199b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00029807 MIMAT0000263 hsa-miR-199b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000263 hsa-miR-199b miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00029808 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029809 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029810 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 19289371 Exosome Plasma Microarray Figure 1: Intensities for specific microRNAs derived from the tumor and exosomes isolated from the plasma of the patients. Data are collected from Figure 1. RLID00029811 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00029812 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00029813 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00029814 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029815 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029816 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029817 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029818 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00029819 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029820 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029821 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029822 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00029823 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 25330373 Microvesicle Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00029824 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029825 MIMAT0000264 hsa-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000264 hsa-miR-203a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029826 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00029827 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029828 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029829 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029830 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029831 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00029832 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029833 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029834 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029835 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00029836 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00029837 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 25330373 Microvesicle Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00029838 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00029839 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029840 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029841 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00029842 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00029843 MIMAT0000265 hsa-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000265 hsa-miR-204 miRNA Homo sapiens 22529849 Exosome Liver carcinoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029844 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00029845 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029846 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029847 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 19289371 Exosome Plasma Microarray Figure 1: Intensities for specific microRNAs derived from the tumor and exosomes isolated from the plasma of the patients. Data are collected from Figure 1. RLID00029848 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 21601258 Exosome Ascites qRT-PCR "Fig. 2. Biochemical marker analysis of exosomes. (A) Exosomes isolated from ascites or pleural effusions of tumor or LC patients were analyzed using the indi cated mAb followed by peroxidase-conjugated secondary antibody and ECL detection. 10 μ g exosomes were applied per lane. Note that HSP70, ADAM10, Annexin-1 and CD9 are considered as general exosome markers. HLA-DR was used as a marker for immune cell derived exosomes. Note that in BrCa patients #9�4 samples were derived from pleural effusions and #15 and 16 were from ascites. (B) The content of the indicated miRNAs was quantified by real-time RT-PCR in exosomes from ascites of OvCa (n=10) or LC patients (n=6) or BrCa pleural effusions (n=7). Note, that low Ct values re fl ect high expression levels of the respective miRNA. P-values in the fi gure are indicated as follows: * < 0.05, ** < 0.01 *** < 0.001. Data are collected from Figure 2. " RLID00029849 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029850 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029851 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029852 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029853 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029854 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 25422181 Cytoplasm Head|Neck tumor tissue In situ hybridization "LNA-ISH revealed that miR-205 exhibited significant differential cytoplasmic and nuclear staining among inflammation, benign and malignant tumors of head and neck. miR-205 was not only exclusively expressed in squamous epithelial malignancy. " RLID00029855 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00029856 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029857 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 25422181 Nucleus Head|Neck tumor tissue In situ hybridization "LNA-ISH revealed that miR-205 exhibited significant differential cytoplasmic and nuclear staining among inflammation, benign and malignant tumors of head and neck. miR-205 was not only exclusively expressed in squamous epithelial malignancy. " RLID00029858 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029859 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00029860 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00029861 MIMAT0000266 hsa-miR-205-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000266 hsa-miR-205 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029862 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029863 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029864 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029865 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00029866 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029867 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029868 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00029869 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029870 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029871 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029872 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029873 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029874 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029875 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029876 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029877 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029878 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029879 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029880 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029881 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029882 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029883 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029884 MIMAT0000267 hsa-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000267 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00029885 MIMAT0000268 hsa-miR-211-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000268 hsa-miR-211 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029886 MIMAT0000268 hsa-miR-211-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000268 hsa-miR-211 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029887 MIMAT0000268 hsa-miR-211-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000268 hsa-miR-211 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029888 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029889 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029890 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 19289371 Exosome Plasma Microarray Figure 1: Intensities for specific microRNAs derived from the tumor and exosomes isolated from the plasma of the patients. Data are collected from Figure 1. RLID00029891 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00029892 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029893 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029894 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029895 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029896 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029897 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029898 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029899 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029900 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029901 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029902 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00029903 MIMAT0000269 hsa-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000269 hsa-miR-212 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029904 MIMAT0000270 hsa-miR-181a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000270 "hsa-miR-213, hsa-miR-181a* " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029905 MIMAT0000270 hsa-miR-181a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000270 "hsa-miR-213, hsa-miR-181a* " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029906 MIMAT0000270 hsa-miR-181a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000270 "hsa-miR-213, hsa-miR-181a* " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029907 MIMAT0000270 hsa-miR-181a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000270 "hsa-miR-213, hsa-miR-181a* " miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029908 MIMAT0000270 hsa-miR-181a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000270 "hsa-miR-213, hsa-miR-181a* " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029909 MIMAT0000270 hsa-miR-181a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000270 "hsa-miR-213, hsa-miR-181a* " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029910 MIMAT0000270 hsa-miR-181a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000270 "hsa-miR-213, hsa-miR-181a* " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029911 MIMAT0000270 hsa-miR-181a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000270 "hsa-miR-213, hsa-miR-181a* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029912 MIMAT0000270 hsa-miR-181a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000270 "hsa-miR-213, hsa-miR-181a* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029913 MIMAT0000270 hsa-miR-181a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000270 "hsa-miR-213, hsa-miR-181a* " miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00029914 MIMAT0000271 hsa-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000271 hsa-miR-214 miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00029915 MIMAT0000271 hsa-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000271 hsa-miR-214 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029916 MIMAT0000271 hsa-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000271 hsa-miR-214 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029917 MIMAT0000271 hsa-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000271 hsa-miR-214 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029918 MIMAT0000271 hsa-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000271 hsa-miR-214 miRNA Homo sapiens 19289371 Exosome Plasma Microarray Figure 1: Intensities for specific microRNAs derived from the tumor and exosomes isolated from the plasma of the patients. Data are collected from Figure 1. RLID00029919 MIMAT0000271 hsa-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000271 hsa-miR-214 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029920 MIMAT0000271 hsa-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000271 hsa-miR-214 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029921 MIMAT0000271 hsa-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000271 hsa-miR-214 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029922 MIMAT0000271 hsa-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000271 hsa-miR-214 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029923 MIMAT0000271 hsa-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000271 hsa-miR-214 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029924 MIMAT0000271 hsa-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000271 hsa-miR-214 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029925 MIMAT0000271 hsa-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000271 hsa-miR-214 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029926 MIMAT0000271 hsa-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000271 hsa-miR-214 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029927 MIMAT0000272 hsa-miR-215-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000272 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029928 MIMAT0000272 hsa-miR-215-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000272 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029929 MIMAT0000272 hsa-miR-215-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000272 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029930 MIMAT0000272 hsa-miR-215-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000272 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029931 MIMAT0000272 hsa-miR-215-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000272 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029932 MIMAT0000272 hsa-miR-215-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000272 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029933 MIMAT0000272 hsa-miR-215-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000272 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029934 MIMAT0000272 hsa-miR-215-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000272 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029935 MIMAT0000272 hsa-miR-215-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000272 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029936 MIMAT0000272 hsa-miR-215-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000272 miRNA Homo sapiens 22529849 Exosome HCC cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029937 MIMAT0000273 hsa-miR-216a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000273 "hsa-miR-216, hsa-miR-216a " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029938 MIMAT0000273 hsa-miR-216a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000273 "hsa-miR-216, hsa-miR-216a " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029939 MIMAT0000274 hsa-miR-217 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000274 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029940 MIMAT0000274 hsa-miR-217 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000274 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029941 MIMAT0000274 hsa-miR-217 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000274 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029942 MIMAT0000275 hsa-miR-218-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000275 hsa-miR-218 miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00029943 MIMAT0000275 hsa-miR-218-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000275 hsa-miR-218 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029944 MIMAT0000275 hsa-miR-218-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000275 hsa-miR-218 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029945 MIMAT0000275 hsa-miR-218-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000275 hsa-miR-218 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029946 MIMAT0000275 hsa-miR-218-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000275 hsa-miR-218 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029947 MIMAT0000275 hsa-miR-218-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000275 hsa-miR-218 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00029948 MIMAT0000275 hsa-miR-218-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000275 hsa-miR-218 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029949 MIMAT0000276 hsa-miR-219a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000276 hsa-miR-219 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029950 MIMAT0000276 hsa-miR-219a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000276 hsa-miR-219 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029951 MIMAT0000276 hsa-miR-219a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000276 hsa-miR-219 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00029952 MIMAT0000276 hsa-miR-219a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000276 hsa-miR-219 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00029953 MIMAT0000276 hsa-miR-219a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000276 hsa-miR-219 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00029954 MIMAT0000276 hsa-miR-219a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000276 hsa-miR-219 miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029955 MIMAT0000276 hsa-miR-219a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000276 hsa-miR-219 miRNA Homo sapiens 22529849 Exosome Liver carcinoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00029956 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029957 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029958 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029959 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029960 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00029961 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00029962 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00029963 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029964 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029965 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 22895844 Exosome Colon|Liver|Lung qRT-PCR "When the RNA species within exosomes derived from the three CRC cell lines were examined, the mRNAs of housekeeping genes such as ACTB and GAPDH, the microRNAs such as miR-21, miR-192 and miR-221, and the natural antisense RNAs of LRRC24, MDM2 and CDKN1A genes, were detected. " RLID00029966 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029967 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029968 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00029969 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00029970 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In contrast to oncomirs, an miRNA that is involved in tumor-suppressing activities, is taken as a tumor suppressor (oncosuppressor). The aberrantly expressed miR-223, which directly targeted Stathmin 1 to inhibit HCC growth, was only found in MVs of liver cancer cell line in our study (table 2). Data are collected from Table 2. " RLID00029971 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00029972 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029973 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00029974 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029975 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00029976 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00029977 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00029978 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029979 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00029980 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00029981 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00029982 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00029983 MIMAT0000278 hsa-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000278 hsa-miR-221 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00029984 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00029985 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029986 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00029987 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00029988 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00029989 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00029990 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00029991 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00029992 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00029993 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00029994 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00029995 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00029996 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00029997 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00029998 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00029999 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030000 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030001 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In contrast to oncomirs, an miRNA that is involved in tumor-suppressing activities, is taken as a tumor suppressor (oncosuppressor). The aberrantly expressed miR-223, which directly targeted Stathmin 1 to inhibit HCC growth, was only found in MVs of liver cancer cell line in our study (table 2). Data are collected from Table 2. " RLID00030002 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030003 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030004 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030005 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030006 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00030007 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030008 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 25165030 Circulating Serum RT-PCR "Although serum microRNAs (miRNAs) play essential roles in the diagnosis of various diseases, little is known about circulating miRNAs in the aging process. Solexa sequencing demonstrated 17 markedly altered miRNAs in the aging process. Quantitative reversn-PCR analysis identified five downregulated miRNAs (miR-29b, miR-106b, miR-130b, miR-142-5p, and miR-340) and three upregulated miRNAs (miR-92a, miR-222, and miR-375) with age. " RLID00030009 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030010 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030011 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030012 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030013 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030014 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030015 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030016 MIMAT0000279 hsa-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000279 hsa-miR-222 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030017 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 21098710 Circulating Serum qRT-PCR "By selecting miRNAs that have 3-fold higher expression in HBV compared with control serum, we identified total of 13 upregulated miRNAs, including miR-375, miR-92a, miR-10a, miR-223, miR-423, miR-23b/a, miR-342-3p, miR-99a, miR-122a, miR-125b, miR-150, and let-7c. As shown in Figure 2, the upregulation of these 13 miRNA expressions in the serum of HBV cases, compared with those of controls, was largely consistent when detected by Solexa in pooled samples and qRT-PCR in individual samples. Data are collected from Figure 2. " RLID00030018 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 22105822 Circulating plasma qRT-PCR "Our study revealed that plasma miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a, and miR-801 were potential circulating markers for diagnosing HCC. The microRNA panel with the seven microRNAs from the multivariate logistic regression model demonstrated high accuracy in the diagnosis of HCC, especially for patients with early BCLC stages (0 and A). " RLID00030019 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 23056289 Circulating Serum qRT-PCR "Circulating miR-17, miR-20a, miR-29c, and miR-223 combined as non-invasive biomarkers in nasopharyngeal carcinoma. " RLID00030020 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030021 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030022 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030023 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030024 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030025 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030026 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030027 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030028 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030029 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 21939504 Exosome Macrophage RT-PCR "MiR-223, a miRNA specific for IL-4-activated macrophages, was detected within the exosomes released by macrophages and was significantly elevated in the co-cultivated SKBR3 and MDA-MB-231 cells. " RLID00030030 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030031 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030032 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In contrast to oncomirs, an miRNA that is involved in tumor-suppressing activities, is taken as a tumor suppressor (oncosuppressor). The aberrantly expressed miR-223, which directly targeted Stathmin 1 to inhibit HCC growth, was only found in MVs of liver cancer cell line in our study (table 2). Data are collected from Table 2. " RLID00030033 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00030034 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030035 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030036 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 25376581 Exosome Saliva RNA-seq "Previous reports suggested that the majority of miRNAs in saliva were concentrated in exosomes. We tested the presence of miRNAs in exosome and nonexosome fractions of saliva in a subset of samples (Fig. 1C; online Supplemental Fig. 4). Two miRNAs (miR-223-3p and miR-148a-3p) detected in RNA-Seq data of multiple individuals were chosen for this experiment. As shown in Fig. 1C, both miRNAs can be detected in all 3 individuals, and they are predominantly present in the exosomal RNA fraction in 2 of 3 individuals. For 1 individual (S1), both miRNAs were detected in both exosomal and nonexosomal fractions. " RLID00030037 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 22529849 Exosome Breast cancer cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030038 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030039 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030040 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 24130905 Circulating Plasma RT-PCR "Overall expression levels of circulating miRNAs: most miRNAs from the designated list were successfully detected (with Ct values between 18 and 35) in virtually all samples. The highest signal was detected for miR-451, -223, -15a, -486-5p, -16, and -21, which is in agreement with literature data " RLID00030041 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00030042 MIMAT0000280 hsa-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000280 hsa-miR-223 miRNA Homo sapiens 20668554 Microvesicle MSC cell qRT-PCR Table 5: Selectively expressed miRNAs from MSC MVs and their cells of origin. Data are collected from Table 5. RLID00030043 MIMAT0000281 hsa-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000281 hsa-miR-224 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030044 MIMAT0000281 hsa-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000281 hsa-miR-224 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 1: Ten miRNAs differentially expressed in both tumor tissue and serum. Data are collected from Table 1. RLID00030045 MIMAT0000281 hsa-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000281 hsa-miR-224 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030046 MIMAT0000281 hsa-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000281 hsa-miR-224 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030047 MIMAT0000281 hsa-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000281 hsa-miR-224 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030048 MIMAT0000281 hsa-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000281 hsa-miR-224 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030049 MIMAT0000281 hsa-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000281 hsa-miR-224 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030050 MIMAT0000281 hsa-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000281 hsa-miR-224 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030051 MIMAT0000281 hsa-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000281 hsa-miR-224 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00030052 MIMAT0000281 hsa-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000281 hsa-miR-224 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030053 MIMAT0000281 hsa-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000281 hsa-miR-224 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030054 MIMAT0000281 hsa-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000281 hsa-miR-224 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030055 MIMAT0000318 hsa-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000318 hsa-miR-200b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030056 MIMAT0000318 hsa-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000318 hsa-miR-200b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030057 MIMAT0000318 hsa-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000318 hsa-miR-200b miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00030058 MIMAT0000318 hsa-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000318 hsa-miR-200b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030059 MIMAT0000318 hsa-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000318 hsa-miR-200b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030060 MIMAT0000318 hsa-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000318 hsa-miR-200b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030061 MIMAT0000318 hsa-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000318 hsa-miR-200b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030062 MIMAT0000318 hsa-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000318 hsa-miR-200b miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00030063 MIMAT0000318 hsa-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000318 hsa-miR-200b miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00030064 MIMAT0000318 hsa-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000318 hsa-miR-200b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030065 MIMAT0000318 hsa-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000318 hsa-miR-200b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030066 MIMAT0000318 hsa-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000318 hsa-miR-200b miRNA Homo sapiens 20864815 Cytoplasm Colon cancer cell RT-PCR|Northern blot|Microarray "MicroRNAs such as let-7d, miR-19a, miR-19b and miR-200b, demonstrated nuclear localization at a level similar to that of cytoplasm. " RLID00030067 MIMAT0000318 hsa-miR-200b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000318 hsa-miR-200b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030068 MIMAT0000366 mmu-miR-290a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000366 mmu-miR-290 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00030069 MIMAT0000366 mmu-miR-290a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000366 mmu-miR-290 miRNA Mus musculus 19266099 Microvesicle Embryonic stem cell qRT-PCR "Figure 5: ESMVs contain miRNAs. The relative abundance of several miRNAs in ESMVs compared with ESCs was determined by real time quantitative RT-PCR. The miRNAs tested include miR-16 (lane 1), miR-21 (lane 2), miR-22 (lane 3), miR-290 (lane 4), miR-291-3p (lane 5), miR-292-3p (lane 6), miR-294 (lane 7), miR-295 (lane 8), and the small nuclear RNA, RNU6b (lane 9). Data are collected from Figure 5. " RLID00030070 MIMAT0000367 mmu-miR-291a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000367 mmu-miR-291-5p miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00030071 MIMAT0000368 mmu-miR-291a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000368 mmu-miR-291-3p miRNA Mus musculus 19266099 Microvesicle Embryonic stem cell qRT-PCR "Figure 5: ESMVs contain miRNAs. The relative abundance of several miRNAs in ESMVs compared with ESCs was determined by real time quantitative RT-PCR. The miRNAs tested include miR-16 (lane 1), miR-21 (lane 2), miR-22 (lane 3), miR-290 (lane 4), miR-291-3p (lane 5), miR-292-3p (lane 6), miR-294 (lane 7), miR-295 (lane 8), and the small nuclear RNA, RNU6b (lane 9). Data are collected from Figure 5. " RLID00030072 MIMAT0000369 mmu-miR-292a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000369 mmu-miR-292-5p miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00030073 MIMAT0000370 mmu-miR-292a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000370 mmu-miR-292-3p miRNA Mus musculus 19266099 Microvesicle Embryonic stem cell qRT-PCR "Figure 5: ESMVs contain miRNAs. The relative abundance of several miRNAs in ESMVs compared with ESCs was determined by real time quantitative RT-PCR. The miRNAs tested include miR-16 (lane 1), miR-21 (lane 2), miR-22 (lane 3), miR-290 (lane 4), miR-291-3p (lane 5), miR-292-3p (lane 6), miR-294 (lane 7), miR-295 (lane 8), and the small nuclear RNA, RNU6b (lane 9). Data are collected from Figure 5. " RLID00030074 MIMAT0000370 mmu-miR-292a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000370 mmu-miR-292-3p miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00030075 MIMAT0000372 mmu-miR-294-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000372 mmu-miR-294 miRNA Mus musculus 19266099 Microvesicle Embryonic stem cell qRT-PCR "Figure 5: ESMVs contain miRNAs. The relative abundance of several miRNAs in ESMVs compared with ESCs was determined by real time quantitative RT-PCR. The miRNAs tested include miR-16 (lane 1), miR-21 (lane 2), miR-22 (lane 3), miR-290 (lane 4), miR-291-3p (lane 5), miR-292-3p (lane 6), miR-294 (lane 7), miR-295 (lane 8), and the small nuclear RNA, RNU6b (lane 9). Data are collected from Figure 5. " RLID00030076 MIMAT0000373 mmu-miR-295-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000373 mmu-miR-295 miRNA Mus musculus 19266099 Microvesicle Embryonic stem cell qRT-PCR "Figure 5: ESMVs contain miRNAs. The relative abundance of several miRNAs in ESMVs compared with ESCs was determined by real time quantitative RT-PCR. The miRNAs tested include miR-16 (lane 1), miR-21 (lane 2), miR-22 (lane 3), miR-290 (lane 4), miR-291-3p (lane 5), miR-292-3p (lane 6), miR-294 (lane 7), miR-295 (lane 8), and the small nuclear RNA, RNU6b (lane 9). Data are collected from Figure 5. " RLID00030077 MIMAT0000374 mmu-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000374 mmu-miR-296 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00030078 MIMAT0000374 mmu-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000374 mmu-miR-296 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00030079 MIMAT0000374 mmu-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000374 mmu-miR-296 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00030080 MIMAT0000374 mmu-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000374 mmu-miR-296 miRNA Mus musculus 23897634 Cell body Neuron ball cultures Fluorescence in situ hybridization Data are collected from Table 2: Cell Body-Enriched miRNAs. RLID00030081 MIMAT0000375 mmu-miR-297a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000375 "mmu-miR-297, mmu-miR-297a " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00030082 MIMAT0000375 mmu-miR-297a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000375 "mmu-miR-297, mmu-miR-297a " miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00030083 MIMAT0000376 mmu-miR-298-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000376 mmu-miR-298 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00030084 MIMAT0000376 mmu-miR-298-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000376 mmu-miR-298 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00030085 MIMAT0000376 mmu-miR-298-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000376 mmu-miR-298 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00030086 MIMAT0000378 mmu-miR-300-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000378 mmu-miR-300 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00030087 MIMAT0000379 mmu-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000379 "mmu-miR-301, mmu-miR-301a " miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00030088 MIMAT0000379 mmu-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000379 "mmu-miR-301, mmu-miR-301a " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00030089 MIMAT0000379 mmu-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000379 "mmu-miR-301, mmu-miR-301a " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00030090 MIMAT0000379 mmu-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000379 "mmu-miR-301, mmu-miR-301a " miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00030091 MIMAT0000381 mmu-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000381 mmu-miR-34c miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00030092 MIMAT0000381 mmu-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000381 mmu-miR-34c miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00030093 MIMAT0000382 mmu-miR-34b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000382 mmu-miR-34b miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00030094 MIMAT0000383 mmu-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000383 mmu-let-7d miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00030095 MIMAT0000383 mmu-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000383 mmu-let-7d miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00030096 MIMAT0000383 mmu-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000383 mmu-let-7d miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00030097 MIMAT0000383 mmu-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000383 mmu-let-7d miRNA Mus musculus 21862971 Nucleus Liver cell Microarray "Supplementary information, Figure S4 Screening for the target miRNAs of miR-709 in the nucleus via microarray assay (only top 44 miRNAs were showed). Data are collected from Figure S4. " RLID00030098 MIMAT0000383 mmu-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000383 mmu-let-7d miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00030099 MIMAT0000384 mmu-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000384 mmu-let-7d* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00030100 MIMAT0000385 mmu-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000385 mmu-miR-106a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00030101 MIMAT0000385 mmu-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000385 mmu-miR-106a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00030102 MIMAT0000385 mmu-miR-106a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000385 mmu-miR-106a miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00030103 MIMAT0000386 mmu-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000386 mmu-miR-106b miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00030104 MIMAT0000386 mmu-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000386 mmu-miR-106b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00030105 MIMAT0000386 mmu-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000386 mmu-miR-106b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00030106 MIMAT0000387 mmu-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000387 mmu-miR-130b miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00030107 MIMAT0000387 mmu-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000387 mmu-miR-130b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00030108 MIMAT0000387 mmu-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000387 mmu-miR-130b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00030109 MIMAT0000387 mmu-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000387 mmu-miR-130b miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00030110 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 22094284 Circulating serum qRT-PCR|RNA-seq "When compared with family schizophrenia patients, circulating miR-219-2-3p, miR-92a, miR-346, let-7g and miR-17 were significantly higher in sporadic schizophrenia ( p < 0.001, Fig. 4 ). On contrary, miR-181b and miR-195 were significantlydown-regulated in sporadic schizophrenia compared with family schizophrenia patients ( p < 0.001), miR-1308 was slightly lower in sporadic schizophrenia compared family schizophrenia patients (0.05 < p < 0.001), and miR-103 was highly consistent between sporadic schizophrenia and family schizophrenia patients ( p > 0.05). These data indicate that there is a close relationship between levels of circulating miRNAs and schizophrenia patients whether they have the family history or not. " RLID00030111 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 22884882 Circulating Plasma Microarray "To explore a potential novel biomarker, we examined the cellular and plasma miRNA profiles in adult T-cell leukemia (ATL) characterized by diverse clinical features. Methods and results : Using CD4-positive cells isolated from 2 non-infected healthy individuals, 3 chronic ATL patients and 3 acute ATL patients, cellular miRNAs were profiled by microarray. The microarray screened 5 miRNAs namely miR-155, let-7g, miR-126, miR-130a and let-7b because of the large difference in their expression in diseased vs. that of healthy controls. " RLID00030112 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030113 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030114 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 24577456 Circulating Serum Next-generation sequencing The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. Table 2 has displayed the data. RLID00030115 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030116 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030117 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030118 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00030119 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030120 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030121 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030122 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030123 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030124 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030125 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00030126 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030127 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030128 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030129 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030130 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030131 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030132 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030133 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030134 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030135 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure (Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00030136 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00030137 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00030138 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00030139 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030140 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030141 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030142 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 21637849 Mitochondrion Myoblast In situ hybridization|qRT-PCR "Other members of the let-7 familly, detected by RT-qPCR, had putative targets. These results suggested that some miRNA detected in the mitochondria like let-7 familly (let-7b, c, d, e, f, i) and mir-140a could be involved in a mitochondrial mRNA silencing regulation. " RLID00030143 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 22529849 Exosome Gastric cancer cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030144 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030145 MIMAT0000414 hsa-let-7g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000414 hsa-let-7g miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030146 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030147 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030148 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030149 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 24981880 Circulating Serum qRT-PCR "Results from recent studies revealed that circulating miRNAs are also potential diagnostic biomarkers and prognostic factors in diabetes. The results of qRT-PCR assessment revealed low serum levels of miR-23a, let-7i, miR-486, miR-96, miR-186, miR-191, miR-192, and miR-146a in T2D. " RLID00030150 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030151 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00030152 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030153 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00030154 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030155 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030156 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030157 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030158 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030159 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00030160 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030161 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030162 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030163 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030164 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030165 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030166 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030167 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00030168 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00030169 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030170 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030171 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030172 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030173 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 21637849 Mitochondrion Myoblast In situ hybridization|qRT-PCR "Other members of the let-7 familly, detected by RT-qPCR, had putative targets. These results suggested that some miRNA detected in the mitochondria like let-7 familly (let-7b, c, d, e, f, i) and mir-141a could be involved in a mitochondrial mRNA silencing regulation. " RLID00030174 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 22529849 Exosome Gastric cancer cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030175 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030176 MIMAT0000415 hsa-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000415 hsa-let-7i miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030177 MIMAT0000416 hsa-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000416 hsa-miR-1 miRNA Homo sapiens 20194856 Circulating Serum Next-generation sequencing "Endogenous circulating miRNAs are stable, are well protected from RNases, and remain stable even after being subjected to harsh conditions. Eleven serum miRNAs were found to be altered more than five-fold by Solexa sequencing between longer-survival and shorter-survival groups, and levels of four miRNAs (ie, miR-486, miR-30d, miR-1 and miR-501) were significantly associated with overall survival. " RLID00030178 MIMAT0000416 hsa-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000416 hsa-miR-1 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030179 MIMAT0000416 hsa-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000416 hsa-miR-1 miRNA Homo sapiens 24456939 Circulating Serum - "In gastric cancer, several circulating miRNAs have been studied as potential diagnostic biomarkers by evaluating their amount in serum, plasma and gastric juice (Table 2). Data are collected from Table 2. " RLID00030180 MIMAT0000416 hsa-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000416 hsa-miR-1 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030181 MIMAT0000416 hsa-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000416 hsa-miR-1 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030182 MIMAT0000416 hsa-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000416 hsa-miR-1 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030183 MIMAT0000416 hsa-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000416 hsa-miR-1 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030184 MIMAT0000416 hsa-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000416 hsa-miR-1 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030185 MIMAT0000416 hsa-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000416 hsa-miR-1 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030186 MIMAT0000416 hsa-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000416 hsa-miR-1 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030187 MIMAT0000416 hsa-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000416 hsa-miR-1 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030188 MIMAT0000416 hsa-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000416 hsa-miR-1 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030189 MIMAT0000416 hsa-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000416 hsa-miR-1 miRNA Homo sapiens 22529849 Exosome Myocard - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030190 MIMAT0000416 hsa-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000416 hsa-miR-1 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030191 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030192 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030193 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030194 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00030195 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00030196 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030197 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030198 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00030199 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030200 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030201 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030202 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030203 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030204 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030205 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030206 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 19011622 Microvesicle Glioblastoma cell qRT-PCR|Microarray "Approximately 4,700 different mRNAs were detected exclusively in microvesicles on both arrays, indicating a selective enrichment process within the microvesicles (Supplementary Table 1). Data are collected from Table S1. " RLID00030207 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030208 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030209 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030210 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030211 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030212 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030213 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00030214 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030215 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00030216 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00030217 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030218 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030219 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030220 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030221 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00030222 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00030223 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030224 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030225 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 22529849 Exosome Glioblastoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030226 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030227 MIMAT0000417 hsa-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000417 hsa-miR-15b miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030228 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 21098710 Circulating Serum qRT-PCR "By selecting miRNAs that have 3-fold higher expression in HBV compared with control serum, we identified total of 13 upregulated miRNAs, including miR-375, miR-92a, miR-10a, miR-223, miR-423, miR-23b/a, miR-342-3p, miR-99a, miR-122a, miR-125b, miR-150, and let-7c. As shown in Figure 2, the upregulation of these 13 miRNA expressions in the serum of HBV cases, compared with those of controls, was largely consistent when detected by Solexa in pooled samples and qRT-PCR in individual samples. Data are collected from Figure 2. " RLID00030229 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030230 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030231 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030232 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00030233 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030234 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030235 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030236 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00030237 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030238 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030239 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030240 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030241 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030242 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030243 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030244 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030245 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030246 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030247 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030248 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030249 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00030250 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030251 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00030252 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030253 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030254 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030255 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030256 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030257 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030258 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030259 MIMAT0000418 hsa-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000418 hsa-miR-23b miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030260 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030261 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030262 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030263 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00030264 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030265 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00030266 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030267 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030268 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00030269 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030270 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030271 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030272 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030273 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030274 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030275 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00030276 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030277 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030278 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00030279 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030280 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030281 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030282 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00030283 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030284 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030285 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030286 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00030287 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00030288 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030289 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030290 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030291 MIMAT0000419 hsa-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000419 hsa-miR-27b miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030292 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030293 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00030294 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030295 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030296 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030297 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00030298 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030299 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030300 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030301 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030302 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030303 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030304 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030305 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030306 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030307 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030308 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030309 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00030310 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030311 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030312 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030313 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030314 MIMAT0000420 hsa-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000420 hsa-miR-30b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030315 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 21098710 Circulating Serum qRT-PCR "By selecting miRNAs that have 3-fold higher expression in HBV compared with control serum, we identified total of 13 upregulated miRNAs, including miR-375, miR-92a, miR-10a, miR-223, miR-423, miR-23b/a, miR-342-3p, miR-99a, miR-122a, miR-125b, miR-150, and let-7c. As shown in Figure 2, the upregulation of these 13 miRNA expressions in the serum of HBV cases, compared with those of controls, was largely consistent when detected by Solexa in pooled samples and qRT-PCR in individual samples. Data are collected from Figure 2. " RLID00030316 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 22105822 Circulating plasma qRT-PCR "Our study revealed that plasma miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a, and miR-801 were potential circulating markers for diagnosing HCC. The microRNA panel with the seven microRNAs from the multivariate logistic regression model demonstrated high accuracy in the diagnosis of HCC, especially for patients with early BCLC stages (0 and A). " RLID00030317 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030318 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030319 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00030320 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 25405200 Circulating Serum qRT-PCR "Individual qRT-PCR results (expression level) of serum miRNA expression in macrosomia and controls is shown in Table 3, including has-miR-122, has-miR-192, has-miR-194, has-miR-296-5p, has-miR-376a, has-miR-487b, has-miR-505, has-miR-1262 " RLID00030321 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030322 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030323 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030324 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030325 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030326 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030327 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030328 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030329 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030330 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00030331 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 25238238 Circulating Serum qRT-PCR "Our study revealed that serum hsa-miR-206, hsa-miR-141-3p, hsa-miR-433-3p, hsa-miR-1228-5p, hsa-miR-199a-5p, hsa-miR-122-5p, hsa-miR-192-5p, and hsa-miR-26a-5p were potential circulating markers for HCC diagnosis. " RLID00030332 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030333 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030334 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 26304123 Endoplasmic reticulum HEK293 cell qRT-PCR "This phenomenon is not HEK293- or let-7a miRNA-specific, and we documented a similar observation for a let-7a reporter in RAW264.7 mouse monocyte/macrophage cells and also for an miR-122 reporter in Huh7 cells expressing miR-122 (Fig. 1, G–I). Data are collected from Figure 1. " RLID00030335 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030336 MIMAT0000421 hsa-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000421 "hsa-miR-122a, hsa-miR-122 " miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030337 MIMAT0000422 hsa-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000422 "hsa-miR-124a, hsa-miR-124 " miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00030338 MIMAT0000422 hsa-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000422 "hsa-miR-124a, hsa-miR-124 " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030339 MIMAT0000422 hsa-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000422 "hsa-miR-124a, hsa-miR-124 " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030340 MIMAT0000422 hsa-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000422 "hsa-miR-124a, hsa-miR-124 " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030341 MIMAT0000422 hsa-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000422 "hsa-miR-124a, hsa-miR-124 " miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00030342 MIMAT0000422 hsa-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000422 "hsa-miR-124a, hsa-miR-124 " miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00030343 MIMAT0000422 hsa-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000422 "hsa-miR-124a, hsa-miR-124 " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030344 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 21098710 Circulating Serum qRT-PCR "By selecting miRNAs that have 3-fold higher expression in HBV compared with control serum, we identified total of 13 upregulated miRNAs, including miR-375, miR-92a, miR-10a, miR-223, miR-423, miR-23b/a, miR-342-3p, miR-99a, miR-122a, miR-125b, miR-150, and let-7c. As shown in Figure 2, the upregulation of these 13 miRNA expressions in the serum of HBV cases, compared with those of controls, was largely consistent when detected by Solexa in pooled samples and qRT-PCR in individual samples. Data are collected from Figure 2. " RLID00030345 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030346 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030347 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030348 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00030349 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00030350 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030351 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00030352 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00030353 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030354 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030355 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030356 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030357 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030358 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00030359 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030360 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030361 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00030362 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030363 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030364 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030365 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030366 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00030367 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00030368 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00030369 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 24627568 Circulating Plasma qRT-PCR "The plasma levels of miR-320b and miR-125b were significantly lower in patients with AMI when compared with controls, and these miRNAs may be involved in the pathogenesis of coronary heart disease. " RLID00030370 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030371 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030372 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030373 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030374 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 24865854 Circulating Plasma qRT-PCR|Next-generation sequcencing "Further exploration of their levels in the plasma of CAD patient and control cases, only circulating miR-361-5p and miR-484 were more abundant in CAD cases by RT-qPCR (Fig. 2D). Levels of circulating miR-140-5p showed no different between healthy and disease population (Fig. 2D). Moreover, levels of miR-342-3p, miR-125b-5p, miR-34a-5p, miR-103a-3p, and miR-125a-5p were even reduced significantly in patient circulation (Fig. 2D). " RLID00030375 MIMAT0000423 hsa-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000423 hsa-miR-125b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030376 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030377 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030378 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030379 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030380 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030381 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00030382 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030383 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030384 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030385 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030386 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030387 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030388 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030389 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030390 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030391 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00030392 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030393 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00030394 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030395 MIMAT0000424 hsa-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000424 hsa-miR-128a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030396 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030397 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030398 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030399 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030400 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00030401 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030402 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00030403 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00030404 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030405 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030406 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030407 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 22884882 Circulating Plasma Microarray "To explore a potential novel biomarker, we examined the cellular and plasma miRNA profiles in adult T-cell leukemia (ATL) characterized by diverse clinical features. Methods and results : Using CD4-positive cells isolated from 2 non-infected healthy individuals, 3 chronic ATL patients and 3 acute ATL patients, cellular miRNAs were profiled by microarray. The microarray screened 5 miRNAs namely miR-155, let-7g, miR-126, miR-130a and let-7b because of the large difference in their expression in diseased vs. that of healthy controls. " RLID00030408 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030409 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030410 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030411 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 24468161 Exosome Breast cancer cell RT-PCR|Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00030412 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030413 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030414 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00030415 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030416 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030417 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030418 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030419 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00030420 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030421 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00030422 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030423 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030424 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030425 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030426 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 25126405 Circulating Serum qRT-PCR "Circulating miRNAs in the serum and plasma are remarkably stable and are suggested to have promise as noninvasive biomarkers for neurological and neurodevelopmental disorders. Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated. " RLID00030427 MIMAT0000425 hsa-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000425 hsa-miR-130a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030428 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030429 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00030430 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030431 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030432 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030433 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030434 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030435 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030436 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030437 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030438 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030439 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030440 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030441 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030442 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030443 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030444 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030445 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030446 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030447 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00030448 MIMAT0000426 hsa-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000426 hsa-miR-132 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030449 MIMAT0000427 hsa-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000427 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030450 MIMAT0000427 hsa-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000427 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030451 MIMAT0000427 hsa-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000427 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030452 MIMAT0000427 hsa-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000427 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030453 MIMAT0000427 hsa-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000427 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030454 MIMAT0000427 hsa-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000427 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030455 MIMAT0000427 hsa-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000427 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030456 MIMAT0000427 hsa-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000427 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030457 MIMAT0000427 hsa-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000427 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030458 MIMAT0000427 hsa-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000427 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00030459 MIMAT0000427 hsa-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000427 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00030460 MIMAT0000427 hsa-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000427 miRNA Homo sapiens 22529849 Exosome Myocard - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030461 MIMAT0000427 hsa-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000427 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030462 MIMAT0000428 hsa-miR-135a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000428 hsa-miR-135a miRNA Homo sapiens 20145944 Circulating Semen RT-PCR|Microarray "Our results highlight four miRNA markers for blood identification (miR-20a, miR-106a, miR-185, and miR-144) and five for semen identification (miR-135a, miR-10a, miR-507, miR-943, and miR-891a). Of those, two miRNA markers for blood (miR-144 and miR-185) and two others for semen (miR-135a and miR-897a) are suggestive to be most useful for body fluid identification in future forensic applications, and the respective RT-PCR assays used here for their detection were highly sensitive, allowing the reliable marker detection from subpicogram amounts of total RNA. Our results proved the applicability of the miRNA approach for forensic body fluids identification. " RLID00030463 MIMAT0000428 hsa-miR-135a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000428 hsa-miR-135a miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00030464 MIMAT0000428 hsa-miR-135a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000428 hsa-miR-135a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030465 MIMAT0000428 hsa-miR-135a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000428 hsa-miR-135a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030466 MIMAT0000428 hsa-miR-135a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000428 hsa-miR-135a miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00030467 MIMAT0000428 hsa-miR-135a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000428 hsa-miR-135a miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030468 MIMAT0000429 hsa-miR-137 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000429 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030469 MIMAT0000429 hsa-miR-137 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000429 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030470 MIMAT0000429 hsa-miR-137 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000429 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030471 MIMAT0000429 hsa-miR-137 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000429 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030472 MIMAT0000429 hsa-miR-137 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000429 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030473 MIMAT0000430 hsa-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000430 hsa-miR-138 miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00030474 MIMAT0000430 hsa-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000430 hsa-miR-138 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030475 MIMAT0000430 hsa-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000430 hsa-miR-138 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030476 MIMAT0000430 hsa-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000430 hsa-miR-138 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030477 MIMAT0000430 hsa-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000430 hsa-miR-138 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030478 MIMAT0000430 hsa-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000430 hsa-miR-138 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030479 MIMAT0000430 hsa-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000430 hsa-miR-138 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030480 MIMAT0000430 hsa-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000430 hsa-miR-138 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00030481 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030482 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030483 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030484 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030485 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030486 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030487 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030488 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030489 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030490 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030491 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00030492 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030493 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030494 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00030495 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00030496 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030497 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030498 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030499 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030500 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 24865854 Circulating Plasma qRT-PCR|Next-generation sequcencing "Further exploration of their levels in the plasma of CAD patient and control cases, only circulating miR-361-5p and miR-484 were more abundant in CAD cases by RT-qPCR (Fig. 2D). Levels of circulating miR-140-5p showed no different between healthy and disease population (Fig. 2D). Moreover, levels of miR-342-3p, miR-125b-5p, miR-34a-5p, miR-103a-3p, and miR-125a-5p were even reduced significantly in patient circulation (Fig. 2D). " RLID00030501 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030502 MIMAT0000431 hsa-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000431 hsa-miR-140 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030503 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 18663219 Circulating Serum qRT-PCR "Circulating microRNAs as stable blood-based markers for cancer detection. This concept extends to cancer in humans, where serum levels of miR-141 (a miRNA expressed in prostate cancer) can distinguish patients with prostate cancer from healthy controls. " RLID00030504 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 21398193 Circulating Blood qRT-PCR "Figure 3: Elevated levels of RNA and miRs in blood of lung cancer patients. The box plot shows the significantly different amounts of RNA, miR10b, miR34a, miR141 and miR155 which circulate in blood of healthy individuals (n = 28), patients with benign lung disease (n = 7) and patients with lung cancer (n = 35). " RLID00030505 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030506 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030507 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030508 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030509 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030510 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030511 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00030512 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00030513 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030514 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030515 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 25238238 Circulating Serum qRT-PCR "Our study revealed that serum hsa-miR-206, hsa-miR-141-3p, hsa-miR-433-3p, hsa-miR-1228-5p, hsa-miR-199a-5p, hsa-miR-122-5p, hsa-miR-192-5p, and hsa-miR-26a-5p were potential circulating markers for HCC diagnosis. " RLID00030516 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030517 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030518 MIMAT0000432 hsa-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000432 hsa-miR-141 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030519 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030520 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030521 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030522 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030523 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030524 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030525 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030526 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030527 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030528 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030529 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030530 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 24633190 Circulating Plasma RT-PCR We also selected 1 miRNA (miR-150-5p) from these 3 mildly up-regulated miRNAs that expressed >= 50 copies in at least one group. The expression levels and the related functions of 8 selected miRNAs are shown in Table 2. Data are collected from Table 2. RLID00030531 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 25165030 Circulating Serum RT-PCR "Although serum microRNAs (miRNAs) play essential roles in the diagnosis of various diseases, little is known about circulating miRNAs in the aging process. Solexa sequencing demonstrated 17 markedly altered miRNAs in the aging process. Quantitative reversn-PCR analysis identified five downregulated miRNAs (miR-29b, miR-106b, miR-130b, miR-142-5p, and miR-340) and three upregulated miRNAs (miR-92a, miR-222, and miR-375) with age. " RLID00030532 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030533 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030534 MIMAT0000433 hsa-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000433 miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00030535 MIMAT0000434 hsa-miR-142-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000434 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030536 MIMAT0000434 hsa-miR-142-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000434 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030537 MIMAT0000434 hsa-miR-142-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000434 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030538 MIMAT0000434 hsa-miR-142-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000434 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030539 MIMAT0000434 hsa-miR-142-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000434 miRNA Homo sapiens 22427800 Exosome Serum RT-PCR The miRNAs tested in serum and saliva samples are shown in Table 1. These miRNAs were selected because they are either ubiquitously expressed or have been reported as biomarkers (Table 1). The relative concentration of these microRNAs was determined by calculating the difference of Ct values between the exosome samples and the exosome-depleted supernatant. A 1-unit difference in the Ct value between the miRNAs isolated from the exosomal pellet or supernatant represents a 2-fold difference in the amount of input miRNA. Data are collected from Table 1: List of miRNAs tested in serum and saliva samples. RLID00030540 MIMAT0000434 hsa-miR-142-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000434 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030541 MIMAT0000434 hsa-miR-142-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000434 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030542 MIMAT0000434 hsa-miR-142-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000434 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030543 MIMAT0000434 hsa-miR-142-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000434 miRNA Homo sapiens 19951903 Microvesicle Plasma qRT-PCR|Microarray "We found several miRNAs whose expression was consistently up-regulated in blood microvesicles samples from IBS patients with increased membrane permeability compared to controls (Figure 2A-lower, left panel). Three up-regulated miRNAs with a p<0.001 were identified: miR-142-3p, miRNA-29a and miR-148b (Figure 2A-lower, left panel). " RLID00030544 MIMAT0000434 hsa-miR-142-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000434 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00030545 MIMAT0000434 hsa-miR-142-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000434 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030546 MIMAT0000434 hsa-miR-142-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000434 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030547 MIMAT0000434 hsa-miR-142-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000434 miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00030548 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00030549 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030550 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030551 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030552 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030553 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030554 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030555 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030556 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00030557 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030558 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In contrast to oncomirs, an miRNA that is involved in tumor-suppressing activities, is taken as a tumor suppressor (oncosuppressor). The aberrantly expressed miR-223, which directly targeted Stathmin 1 to inhibit HCC growth, was only found in MVs of liver cancer cell line in our study (table 2). Data are collected from Table 2. " RLID00030559 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030560 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00030561 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00030562 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00030563 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030564 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030565 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030566 MIMAT0000435 hsa-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000435 hsa-miR-143 miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00030567 MIMAT0000436 hsa-miR-144-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000436 hsa-miR-144 miRNA Homo sapiens 20145944 Circulating Blood RT-PCR|Microarray "Our results highlight four miRNA markers for blood identification (miR-20a, miR-106a, miR-185, and miR-144) and five for semen identification (miR-135a, miR-10a, miR-507, miR-943, and miR-891a). Of those, two miRNA markers for blood (miR-144 and miR-185) and two others for semen (miR-135a and miR-897a) are suggestive to be most useful for body fluid identification in future forensic applications, and the respective RT-PCR assays used here for their detection were highly sensitive, allowing the reliable marker detection from subpicogram amounts of total RNA. Our results proved the applicability of the miRNA approach for forensic body fluids identification. " RLID00030568 MIMAT0000436 hsa-miR-144-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000436 hsa-miR-144 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030569 MIMAT0000436 hsa-miR-144-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000436 hsa-miR-144 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030570 MIMAT0000436 hsa-miR-144-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000436 hsa-miR-144 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030571 MIMAT0000436 hsa-miR-144-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000436 hsa-miR-144 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030572 MIMAT0000436 hsa-miR-144-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000436 hsa-miR-144 miRNA Homo sapiens 25017274 Circulating Serum qRT-PCR "The expression of four miRNAs (miR-1233, miR-520, miR-210, miR-144) was validated by quantitative real-time polymerase chain reaction analysis. MiR-1233 was the most overexpressed in the serum of women who later developed sPE. Circulating miRNAs deserve further investigation in order to explore their potential role in the pathogenesis of preeclampsia. In particular, miR-1233 might represent a potential marker of early sPE. " RLID00030573 MIMAT0000436 hsa-miR-144-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000436 hsa-miR-144 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00030574 MIMAT0000436 hsa-miR-144-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000436 hsa-miR-144 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00030575 MIMAT0000436 hsa-miR-144-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000436 hsa-miR-144 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030576 MIMAT0000436 hsa-miR-144-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000436 hsa-miR-144 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030577 MIMAT0000436 hsa-miR-144-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000436 hsa-miR-144 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030578 MIMAT0000437 hsa-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000437 hsa-miR-145 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030579 MIMAT0000437 hsa-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000437 hsa-miR-145 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030580 MIMAT0000437 hsa-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000437 hsa-miR-145 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030581 MIMAT0000437 hsa-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000437 hsa-miR-145 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030582 MIMAT0000437 hsa-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000437 hsa-miR-145 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030583 MIMAT0000437 hsa-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000437 hsa-miR-145 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030584 MIMAT0000437 hsa-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000437 hsa-miR-145 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030585 MIMAT0000437 hsa-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000437 hsa-miR-145 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030586 MIMAT0000437 hsa-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000437 hsa-miR-145 miRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00030587 MIMAT0000437 hsa-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000437 hsa-miR-145 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00030588 MIMAT0000437 hsa-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000437 hsa-miR-145 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00030589 MIMAT0000437 hsa-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000437 hsa-miR-145 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030590 MIMAT0000437 hsa-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000437 hsa-miR-145 miRNA Homo sapiens 22529849 Exosome Liver carcinoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030591 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030592 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030593 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030594 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00030595 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030596 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00030597 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030598 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030599 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030600 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030601 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030602 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030603 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030604 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030605 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030606 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030607 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030608 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030609 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030610 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00030611 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030612 MIMAT0000438 hsa-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000438 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030613 MIMAT0000439 hsa-miR-153-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000439 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030614 MIMAT0000439 hsa-miR-153-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000439 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030615 MIMAT0000439 hsa-miR-153-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000439 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030616 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030617 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030618 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030619 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030620 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 24981880 Circulating Serum qRT-PCR "Results from recent studies revealed that circulating miRNAs are also potential diagnostic biomarkers and prognostic factors in diabetes. The results of qRT-PCR assessment revealed low serum levels of miR-23a, let-7i, miR-486, miR-96, miR-186, miR-191, miR-192, and miR-146a in T2D. " RLID00030621 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030622 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00030623 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030624 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030625 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 19289371 Exosome Plasma Microarray Figure 1: Intensities for specific microRNAs derived from the tumor and exosomes isolated from the plasma of the patients. Data are collected from Figure 1. RLID00030626 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00030627 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030628 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030629 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030630 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030631 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030632 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030633 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030634 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030635 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030636 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00030637 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030638 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030639 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030640 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR "Even under such stringent criteria, 11 miRNAs can be identified as miRNAs that are detectable in the nucleolus with very high levels of confidence (Figure 1D, Table S2). Since the detected nucleolar contents of many of these RNAs are very high, we termed these 11 miRNAs as nucleolar miRNAs. " RLID00030641 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030642 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00030643 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030644 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00030645 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00030646 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00030647 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00030648 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030649 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030650 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030651 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030652 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 24577456 Circulating Serum Next-generation sequencing The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. Table 2 has displayed the data. RLID00030653 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR|In situ hybridization "Through in situ hybridisation, we have localised these miRNAs, including miR-191 and miR-484, in the nucleolus of a diversity of human and rodent cell lines. Four cleolar miRNAs; miR191, miR-484, miR-574-3p and miR-193b, were tested in our ISH experiments, and all four miRNAs exhibit strong nucleolar localisation (Figure 2A). " RLID00030654 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030655 MIMAT0000440 hsa-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000440 hsa-miR-191 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030656 MIMAT0000441 hsa-miR-9-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000441 hsa-miR-9 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030657 MIMAT0000441 hsa-miR-9-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000441 hsa-miR-9 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00030658 MIMAT0000441 hsa-miR-9-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000441 hsa-miR-9 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030659 MIMAT0000441 hsa-miR-9-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000441 hsa-miR-9 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030660 MIMAT0000441 hsa-miR-9-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000441 hsa-miR-9 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030661 MIMAT0000441 hsa-miR-9-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000441 hsa-miR-9 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030662 MIMAT0000441 hsa-miR-9-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000441 hsa-miR-9 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030663 MIMAT0000441 hsa-miR-9-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000441 hsa-miR-9 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00030664 MIMAT0000441 hsa-miR-9-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000441 hsa-miR-9 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00030665 MIMAT0000441 hsa-miR-9-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000441 hsa-miR-9 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00030666 MIMAT0000441 hsa-miR-9-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000441 hsa-miR-9 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00030667 MIMAT0000442 hsa-miR-9-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000442 hsa-miR-9* miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00030668 MIMAT0000442 hsa-miR-9-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000442 hsa-miR-9* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030669 MIMAT0000442 hsa-miR-9-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000442 hsa-miR-9* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030670 MIMAT0000442 hsa-miR-9-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000442 hsa-miR-9* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030671 MIMAT0000442 hsa-miR-9-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000442 hsa-miR-9* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030672 MIMAT0000442 hsa-miR-9-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000442 hsa-miR-9* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030673 MIMAT0000442 hsa-miR-9-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000442 hsa-miR-9* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030674 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030675 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030676 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030677 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030678 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030679 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030680 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00030681 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030682 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030683 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030684 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030685 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030686 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030687 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030688 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00030689 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030690 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030691 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030692 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR "Even under such stringent criteria, 11 miRNAs can be identified as miRNAs that are detectable in the nucleolus with very high levels of confidence (Figure 1D, Table S2). Since the detected nucleolar contents of many of these RNAs are very high, we termed these 11 miRNAs as nucleolar miRNAs. " RLID00030693 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030694 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030695 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00030696 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00030697 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030698 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030699 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 24865854 Circulating Plasma qRT-PCR|Next-generation sequcencing "Further exploration of their levels in the plasma of CAD patient and control cases, only circulating miR-361-5p and miR-484 were more abundant in CAD cases by RT-qPCR (Fig. 2D). Levels of circulating miR-140-5p showed no different between healthy and disease population (Fig. 2D). Moreover, levels of miR-342-3p, miR-125b-5p, miR-34a-5p, miR-103a-3p, and miR-125a-5p were even reduced significantly in patient circulation (Fig. 2D). " RLID00030700 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00030701 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00030702 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00030703 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030704 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030705 MIMAT0000443 hsa-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000443 hsa-miR-125a miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030706 MIMAT0000444 hsa-miR-126-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000444 hsa-miR-126* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030707 MIMAT0000444 hsa-miR-126-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000444 hsa-miR-126* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030708 MIMAT0000444 hsa-miR-126-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000444 hsa-miR-126* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030709 MIMAT0000444 hsa-miR-126-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000444 hsa-miR-126* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030710 MIMAT0000444 hsa-miR-126-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000444 hsa-miR-126* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030711 MIMAT0000444 hsa-miR-126-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000444 hsa-miR-126* miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030712 MIMAT0000444 hsa-miR-126-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000444 hsa-miR-126* miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030713 MIMAT0000444 hsa-miR-126-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000444 hsa-miR-126* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030714 MIMAT0000444 hsa-miR-126-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000444 hsa-miR-126* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00030715 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 18954897 Circulating Serum qRT-PCR Fig. 2. Median fold-change differences in differentially expressed miRNAs between patient and control serum. Data are collected from Figure 2. RLID00030716 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030717 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030718 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030719 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030720 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030721 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00030722 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030723 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030724 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 22884882 Circulating Plasma Microarray|qRT-PCR "To explore a potential novel biomarker, we examined the cellular and plasma miRNA profiles in adult T-cell leukemia (ATL) characterized by diverse clinical features. Methods and results : Using CD4-positive cells isolated from 2 non-infected healthy individuals, 3 chronic ATL patients and 3 acute ATL patients, cellular miRNAs were profiled by microarray. The microarray screened 5 miRNAs namely miR-155, let-7g, miR-126, miR-130a and let-7b because of the large difference in their expression in diseased vs. that of healthy controls. " RLID00030725 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030726 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030727 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030728 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030729 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030730 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030731 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030732 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030733 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00030734 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00030735 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030736 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030737 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030738 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030739 MIMAT0000445 hsa-miR-126-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000445 hsa-miR-126 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030740 MIMAT0000446 hsa-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000446 hsa-miR-127 miRNA Homo sapiens 18954897 Circulating Serum qRT-PCR Fig. 2. Median fold-change differences in differentially expressed miRNAs between patient and control serum. Data are collected from Figure 2. RLID00030741 MIMAT0000446 hsa-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000446 hsa-miR-127 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030742 MIMAT0000446 hsa-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000446 hsa-miR-127 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030743 MIMAT0000446 hsa-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000446 hsa-miR-127 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030744 MIMAT0000446 hsa-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000446 hsa-miR-127 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030745 MIMAT0000446 hsa-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000446 hsa-miR-127 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030746 MIMAT0000446 hsa-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000446 hsa-miR-127 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030747 MIMAT0000446 hsa-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000446 hsa-miR-127 miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00030748 MIMAT0000446 hsa-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000446 hsa-miR-127 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00030749 MIMAT0000446 hsa-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000446 hsa-miR-127 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030750 MIMAT0000446 hsa-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000446 hsa-miR-127 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030751 MIMAT0000446 hsa-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000446 hsa-miR-127 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00030752 MIMAT0000446 hsa-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000446 hsa-miR-127 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00030753 MIMAT0000446 hsa-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000446 hsa-miR-127 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030754 MIMAT0000447 hsa-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000447 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030755 MIMAT0000447 hsa-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000447 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00030756 MIMAT0000447 hsa-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000447 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030757 MIMAT0000447 hsa-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000447 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030758 MIMAT0000447 hsa-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000447 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030759 MIMAT0000447 hsa-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000447 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030760 MIMAT0000447 hsa-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000447 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030761 MIMAT0000447 hsa-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000447 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030762 MIMAT0000448 hsa-miR-136-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000448 hsa-miR-136 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030763 MIMAT0000448 hsa-miR-136-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000448 hsa-miR-136 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030764 MIMAT0000448 hsa-miR-136-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000448 hsa-miR-136 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030765 MIMAT0000448 hsa-miR-136-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000448 hsa-miR-136 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030766 MIMAT0000448 hsa-miR-136-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000448 hsa-miR-136 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00030767 MIMAT0000448 hsa-miR-136-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000448 hsa-miR-136 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030768 MIMAT0000448 hsa-miR-136-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000448 hsa-miR-136 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030769 MIMAT0000448 hsa-miR-136-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000448 hsa-miR-136 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00030770 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00030771 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030772 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030773 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030774 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030775 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 24981880 Circulating Serum qRT-PCR "Results from recent studies revealed that circulating miRNAs are also potential diagnostic biomarkers and prognostic factors in diabetes. The results of qRT-PCR assessment revealed low serum levels of miR-23a, let-7i, miR-486, miR-96, miR-186, miR-191, miR-192, and miR-146a in T2D. " RLID00030776 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030777 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030778 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 19289371 Exosome Plasma Microarray Figure 1: Intensities for specific microRNAs derived from the tumor and exosomes isolated from the plasma of the patients. Data are collected from Figure 1. RLID00030779 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030780 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030781 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030782 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030783 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030784 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030785 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030786 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030787 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030788 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030789 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00030790 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00030791 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030792 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030793 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030794 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00030795 MIMAT0000449 hsa-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000449 "hsa-miR-146, hsa-miR-146a " miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030796 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030797 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030798 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030799 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030800 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030801 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030802 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030803 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030804 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030805 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030806 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030807 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030808 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030809 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030810 MIMAT0000450 hsa-miR-149-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000450 hsa-miR-149 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030811 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 21098710 Circulating Serum qRT-PCR "By selecting miRNAs that have 3-fold higher expression in HBV compared with control serum, we identified total of 13 upregulated miRNAs, including miR-375, miR-92a, miR-10a, miR-223, miR-423, miR-23b/a, miR-342-3p, miR-99a, miR-122a, miR-125b, miR-150, and let-7c. As shown in Figure 2, the upregulation of these 13 miRNA expressions in the serum of HBV cases, compared with those of controls, was largely consistent when detected by Solexa in pooled samples and qRT-PCR in individual samples. Data are collected from Figure 2. " RLID00030812 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030813 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030814 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030815 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030816 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 19823581 Exosome Plasma qRT-PCR|Microarray MiR-150 levels in plasma are significantly reduced in sepsis patients compared with controls and correlate with the Level of sepsis severity. RLID00030817 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030818 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030819 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030820 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030821 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030822 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030823 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030824 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030825 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00030826 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030827 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030828 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 24633190 Circulating Plasma RT-PCR We also selected 1 miRNA (miR-150-5p) from these 3 mildly up-regulated miRNAs that expressed >= 50 copies in at least one group. The expression levels and the related functions of 8 selected miRNAs are shown in Table 2. Data are collected from Table 2. RLID00030829 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030830 MIMAT0000451 hsa-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000451 hsa-miR-150 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00030831 MIMAT0000452 hsa-miR-154-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000452 hsa-miR-154 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030832 MIMAT0000452 hsa-miR-154-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000452 hsa-miR-154 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030833 MIMAT0000452 hsa-miR-154-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000452 hsa-miR-154 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030834 MIMAT0000452 hsa-miR-154-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000452 hsa-miR-154 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030835 MIMAT0000453 hsa-miR-154-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000453 hsa-miR-154* miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00030836 MIMAT0000453 hsa-miR-154-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000453 hsa-miR-154* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030837 MIMAT0000453 hsa-miR-154-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000453 hsa-miR-154* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030838 MIMAT0000453 hsa-miR-154-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000453 hsa-miR-154* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030839 MIMAT0000453 hsa-miR-154-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000453 hsa-miR-154* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030840 MIMAT0000454 hsa-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000454 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 1: Ten miRNAs differentially expressed in both tumor tissue and serum. Data are collected from Table 1. RLID00030841 MIMAT0000454 hsa-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000454 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030842 MIMAT0000454 hsa-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000454 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030843 MIMAT0000454 hsa-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000454 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030844 MIMAT0000454 hsa-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000454 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030845 MIMAT0000454 hsa-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000454 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030846 MIMAT0000454 hsa-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000454 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030847 MIMAT0000454 hsa-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000454 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030848 MIMAT0000454 hsa-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000454 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00030849 MIMAT0000454 hsa-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000454 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00030850 MIMAT0000454 hsa-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000454 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030851 MIMAT0000454 hsa-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000454 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030852 MIMAT0000454 hsa-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000454 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030853 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 20145944 Circulating Blood RT-PCR|Microarray "Our results highlight four miRNA markers for blood identification (miR-20a, miR-106a, miR-185, and miR-144) and five for semen identification (miR-135a, miR-10a, miR-507, miR-943, and miR-891a). Of those, two miRNA markers for blood (miR-144 and miR-185) and two others for semen (miR-135a and miR-897a) are suggestive to be most useful for body fluid identification in future forensic applications, and the respective RT-PCR assays used here for their detection were highly sensitive, allowing the reliable marker detection from subpicogram amounts of total RNA. Our results proved the applicability of the miRNA approach for forensic body fluids identification. " RLID00030854 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030855 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030856 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030857 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030858 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030859 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030860 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030861 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030862 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030863 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030864 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030865 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030866 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030867 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030868 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030869 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030870 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030871 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00030872 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030873 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030874 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030875 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030876 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030877 MIMAT0000455 hsa-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000455 hsa-miR-185 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030878 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030879 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030880 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030881 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030882 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 24981880 Circulating Serum qRT-PCR "Results from recent studies revealed that circulating miRNAs are also potential diagnostic biomarkers and prognostic factors in diabetes. The results of qRT-PCR assessment revealed low serum levels of miR-23a, let-7i, miR-486, miR-96, miR-186, miR-191, miR-192, and miR-146a in T2D. " RLID00030883 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030884 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030885 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030886 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030887 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030888 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030889 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030890 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030891 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030892 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00030893 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030894 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030895 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030896 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030897 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030898 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00030899 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030900 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00030901 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030902 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030903 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030904 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030905 MIMAT0000456 hsa-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000456 hsa-miR-186 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030906 MIMAT0000457 hsa-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000457 hsa-miR-188 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030907 MIMAT0000457 hsa-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000457 hsa-miR-188 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030908 MIMAT0000457 hsa-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000457 hsa-miR-188 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030909 MIMAT0000457 hsa-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000457 hsa-miR-188 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030910 MIMAT0000457 hsa-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000457 hsa-miR-188 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030911 MIMAT0000457 hsa-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000457 hsa-miR-188 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030912 MIMAT0000457 hsa-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000457 hsa-miR-188 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030913 MIMAT0000457 hsa-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000457 hsa-miR-188 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00030914 MIMAT0000457 hsa-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000457 hsa-miR-188 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030915 MIMAT0000457 hsa-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000457 hsa-miR-188 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030916 MIMAT0000457 hsa-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000457 hsa-miR-188 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030917 MIMAT0000457 hsa-miR-188-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000457 hsa-miR-188 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030918 MIMAT0000458 hsa-miR-190a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000458 hsa-miR-190 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030919 MIMAT0000458 hsa-miR-190a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000458 hsa-miR-190 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030920 MIMAT0000458 hsa-miR-190a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000458 hsa-miR-190 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030921 MIMAT0000458 hsa-miR-190a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000458 hsa-miR-190 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030922 MIMAT0000458 hsa-miR-190a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000458 hsa-miR-190 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030923 MIMAT0000458 hsa-miR-190a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000458 hsa-miR-190 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00030924 MIMAT0000458 hsa-miR-190a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000458 hsa-miR-190 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00030925 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030926 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030927 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030928 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030929 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030930 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030931 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030932 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030933 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00030934 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030935 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030936 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00030937 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 25330373 Microvesicle Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00030938 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030939 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030940 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00030941 MIMAT0000459 hsa-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000459 "hsa-miR-193, hsa-miR-193a " miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00030942 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030943 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030944 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00030945 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 25405200 Circulating Serum qRT-PCR "Individual qRT-PCR results (expression level) of serum miRNA expression in macrosomia and controls is shown in Table 3, including has-miR-122, has-miR-192, has-miR-194, has-miR-296-5p, has-miR-376a, has-miR-487b, has-miR-505, has-miR-1262 " RLID00030946 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030947 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030948 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030949 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030950 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030951 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030952 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00030953 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030954 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030955 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030956 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030957 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030958 MIMAT0000460 hsa-miR-194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000460 hsa-miR-194 miRNA Homo sapiens 20668554 Microvesicle MSC cell qRT-PCR Table 5: Selectively expressed miRNAs from MSC MVs and their cells of origin. Data are collected from Table 5. RLID00030959 MIMAT0000461 hsa-miR-195-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000461 hsa-miR-195 miRNA Homo sapiens 22094284 Circulating serum qRT-PCR|RNA-seq "When compared with family schizophrenia patients, circulating miR-219-2-3p, miR-92a, miR-346, let-7g and miR-17 were significantly higher in sporadic schizophrenia ( p < 0.001, Fig. 4 ). On contrary, miR-181b and miR-195 were significantlydown-regulated in sporadic schizophrenia compared with family schizophrenia patients ( p < 0.001), miR-1308 was slightly lower in sporadic schizophrenia compared family schizophrenia patients (0.05 < p < 0.001), and miR-103 was highly consistent between sporadic schizophrenia and family schizophrenia patients ( p > 0.05). These data indicate that there is a close relationship between levels of circulating miRNAs and schizophrenia patients whether they have the family history or not. " RLID00030960 MIMAT0000461 hsa-miR-195-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000461 hsa-miR-195 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00030961 MIMAT0000461 hsa-miR-195-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000461 hsa-miR-195 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030962 MIMAT0000461 hsa-miR-195-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000461 hsa-miR-195 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030963 MIMAT0000461 hsa-miR-195-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000461 hsa-miR-195 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030964 MIMAT0000461 hsa-miR-195-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000461 hsa-miR-195 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030965 MIMAT0000461 hsa-miR-195-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000461 hsa-miR-195 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030966 MIMAT0000461 hsa-miR-195-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000461 hsa-miR-195 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00030967 MIMAT0000461 hsa-miR-195-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000461 hsa-miR-195 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030968 MIMAT0000461 hsa-miR-195-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000461 hsa-miR-195 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00030969 MIMAT0000461 hsa-miR-195-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000461 hsa-miR-195 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00030970 MIMAT0000461 hsa-miR-195-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000461 hsa-miR-195 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030971 MIMAT0000461 hsa-miR-195-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000461 hsa-miR-195 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030972 MIMAT0000461 hsa-miR-195-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000461 hsa-miR-195 miRNA Homo sapiens 25126405 Circulating Serum qRT-PCR "Circulating miRNAs in the serum and plasma are remarkably stable and are suggested to have promise as noninvasive biomarkers for neurological and neurodevelopmental disorders. Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated. " RLID00030973 MIMAT0000462 hsa-miR-206 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000462 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030974 MIMAT0000462 hsa-miR-206 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000462 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030975 MIMAT0000462 hsa-miR-206 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000462 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00030976 MIMAT0000462 hsa-miR-206 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000462 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030977 MIMAT0000462 hsa-miR-206 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000462 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030978 MIMAT0000462 hsa-miR-206 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000462 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00030979 MIMAT0000462 hsa-miR-206 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000462 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00030980 MIMAT0000462 hsa-miR-206 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000462 miRNA Homo sapiens 25238238 Circulating Serum qRT-PCR "Our study revealed that serum hsa-miR-206, hsa-miR-141-3p, hsa-miR-433-3p, hsa-miR-1228-5p, hsa-miR-199a-5p, hsa-miR-122-5p, hsa-miR-192-5p, and hsa-miR-26a-5p were potential circulating markers for HCC diagnosis. " RLID00030981 MIMAT0000462 hsa-miR-206 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000462 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00030982 MIMAT0000462 hsa-miR-206 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000462 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00030983 MIMAT0000462 hsa-miR-206 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000462 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00030984 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030985 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00030986 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00030987 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00030988 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 25126405 Circulating Serum qRT-PCR "Circulating miRNAs in the serum and plasma are remarkably stable and are suggested to have promise as noninvasive biomarkers for neurological and neurodevelopmental disorders. Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated. " RLID00030989 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00030990 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00030991 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00030992 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00030993 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00030994 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00030995 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00030996 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00030997 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00030998 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 19011622 Microvesicle Glioblastoma cell qRT-PCR|Microarray "Approximately 4,700 different mRNAs were detected exclusively in microvesicles on both arrays, indicating a selective enrichment process within the microvesicles (Supplementary Table 1). Data are collected from Table S1. " RLID00030999 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00031000 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031001 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031002 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031003 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031004 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031005 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031006 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00031007 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031008 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00031009 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00031010 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00031011 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00031012 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00031013 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031014 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031015 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031016 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031017 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00031018 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031019 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 22529849 Exosome Glioblastoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031020 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031021 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031022 MIMAT0000510 hsa-miR-320a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000510 hsa-miR-320 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00031023 MIMAT0000513 mmu-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000513 mmu-miR-19b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031024 MIMAT0000513 mmu-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000513 mmu-miR-19b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031025 MIMAT0000513 mmu-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000513 mmu-miR-19b miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031026 MIMAT0000513 mmu-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000513 mmu-miR-19b miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00031027 MIMAT0000513 mmu-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000513 mmu-miR-19b miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031028 MIMAT0000514 mmu-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000514 mmu-miR-30c miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031029 MIMAT0000514 mmu-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000514 mmu-miR-30c miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031030 MIMAT0000514 mmu-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000514 mmu-miR-30c miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031031 MIMAT0000514 mmu-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000514 mmu-miR-30c miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031032 MIMAT0000514 mmu-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000514 mmu-miR-30c miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00031033 MIMAT0000515 mmu-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000515 mmu-miR-30d miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031034 MIMAT0000515 mmu-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000515 mmu-miR-30d miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031035 MIMAT0000516 mmu-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000516 mmu-miR-148a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031036 MIMAT0000516 mmu-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000516 mmu-miR-148a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031037 MIMAT0000516 mmu-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000516 mmu-miR-148a miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031038 MIMAT0000517 mmu-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000517 mmu-miR-192 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031039 MIMAT0000517 mmu-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000517 mmu-miR-192 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031040 MIMAT0000517 mmu-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000517 mmu-miR-192 miRNA Mus musculus 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00031041 MIMAT0000517 mmu-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000517 mmu-miR-192 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031042 MIMAT0000517 mmu-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000517 mmu-miR-192 miRNA Mus musculus 23897634 Axon Neuron ball cultures Fluorescence in situ hybridization "We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)].We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)]. Data are collected from Table 1. " RLID00031043 MIMAT0000518 mmu-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000518 mmu-miR-196a miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031044 MIMAT0000521 mmu-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000521 mmu-let-7a miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031045 MIMAT0000521 mmu-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000521 mmu-let-7a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031046 MIMAT0000521 mmu-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000521 mmu-let-7a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031047 MIMAT0000521 mmu-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000521 mmu-let-7a miRNA Mus musculus 21862971 Nucleus Liver cell Microarray "Supplementary information, Figure S4 Screening for the target miRNAs of miR-709 in the nucleus via microarray assay (only top 44 miRNAs were showed). Data are collected from Figure S4. " RLID00031048 MIMAT0000521 mmu-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000521 mmu-let-7a miRNA Mus musculus 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00031049 MIMAT0000522 mmu-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000522 mmu-let-7b miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031050 MIMAT0000522 mmu-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000522 mmu-let-7b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031051 MIMAT0000522 mmu-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000522 mmu-let-7b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031052 MIMAT0000522 mmu-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000522 mmu-let-7b miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031053 MIMAT0000522 mmu-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000522 mmu-let-7b miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031054 MIMAT0000523 mmu-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000523 mmu-let-7c miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031055 MIMAT0000523 mmu-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000523 mmu-let-7c miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031056 MIMAT0000523 mmu-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000523 mmu-let-7c miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031057 MIMAT0000523 mmu-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000523 mmu-let-7c miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031058 MIMAT0000524 mmu-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000524 mmu-let-7e miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031059 MIMAT0000524 mmu-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000524 mmu-let-7e miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031060 MIMAT0000524 mmu-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000524 mmu-let-7e miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031061 MIMAT0000524 mmu-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000524 mmu-let-7e miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031062 MIMAT0000524 mmu-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000524 mmu-let-7e miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031063 MIMAT0000524 mmu-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000524 mmu-let-7e miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00031064 MIMAT0000525 mmu-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000525 mmu-let-7f miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031065 MIMAT0000525 mmu-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000525 mmu-let-7f miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031066 MIMAT0000525 mmu-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000525 mmu-let-7f miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (?42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031067 MIMAT0000525 mmu-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000525 mmu-let-7f miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00031068 MIMAT0000525 mmu-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000525 mmu-let-7f miRNA Mus musculus 21862971 Nucleus Liver cell Microarray "Supplementary information, Figure S4 Screening for the target miRNAs of miR-709 in the nucleus via microarray assay (only top 44 miRNAs were showed). Data are collected from Figure S4. " RLID00031069 MIMAT0000526 mmu-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000526 mmu-miR-15a miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031070 MIMAT0000526 mmu-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000526 mmu-miR-15a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031071 MIMAT0000526 mmu-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000526 mmu-miR-15a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031072 MIMAT0000526 mmu-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000526 mmu-miR-15a miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00031073 MIMAT0000526 mmu-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000526 mmu-miR-15a miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031074 MIMAT0000526 mmu-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000526 mmu-miR-15a miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031075 MIMAT0000526 mmu-miR-15a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000526 mmu-miR-15a miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00031076 MIMAT0000527 mmu-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000527 mmu-miR-16 miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00031077 MIMAT0000527 mmu-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000527 mmu-miR-16 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031078 MIMAT0000527 mmu-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000527 mmu-miR-16 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031079 MIMAT0000527 mmu-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000527 mmu-miR-16 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031080 MIMAT0000527 mmu-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000527 mmu-miR-16 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031081 MIMAT0000527 mmu-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000527 mmu-miR-16 miRNA Mus musculus 19266099 Microvesicle Embryonic stem cell qRT-PCR "Figure 5: ESMVs contain miRNAs. The relative abundance of several miRNAs in ESMVs compared with ESCs was determined by real time quantitative RT-PCR. The miRNAs tested include miR-16 (lane 1), miR-21 (lane 2), miR-22 (lane 3), miR-290 (lane 4), miR-291-3p (lane 5), miR-292-3p (lane 6), miR-294 (lane 7), miR-295 (lane 8), and the small nuclear RNA, RNU6b (lane 9). Data are collected from Figure 5. " RLID00031082 MIMAT0000527 mmu-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000527 mmu-miR-16 miRNA Mus musculus 23897634 Cell body Neuron ball cultures Fluorescence in situ hybridization Data are collected from Table 2: Cell Body-Enriched miRNAs. RLID00031083 MIMAT0000528 mmu-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000528 "mmu-miR-18, mmu-miR-18a " miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031084 MIMAT0000528 mmu-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000528 "mmu-miR-18, mmu-miR-18a " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031085 MIMAT0000528 mmu-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000528 "mmu-miR-18, mmu-miR-18a " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031086 MIMAT0000529 mmu-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000529 "mmu-miR-20, mmu-miR-20a " miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031087 MIMAT0000529 mmu-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000529 "mmu-miR-20, mmu-miR-20a " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031088 MIMAT0000529 mmu-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000529 "mmu-miR-20, mmu-miR-20a " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031089 MIMAT0000530 mmu-miR-21a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000530 "mmu-miR-21, mmu-miR-21-5p " miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00031090 MIMAT0000530 mmu-miR-21a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000530 "mmu-miR-21, mmu-miR-21-5p " miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031091 MIMAT0000530 mmu-miR-21a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000530 "mmu-miR-21, mmu-miR-21-5p " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031092 MIMAT0000530 mmu-miR-21a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000530 "mmu-miR-21, mmu-miR-21-5p " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031093 MIMAT0000530 mmu-miR-21a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000530 "mmu-miR-21, mmu-miR-21-5p " miRNA Mus musculus 21862971 Nucleus Liver cell Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031094 MIMAT0000530 mmu-miR-21a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000530 "mmu-miR-21, mmu-miR-21-5p " miRNA Mus musculus 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00031095 MIMAT0000530 mmu-miR-21a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000530 "mmu-miR-21, mmu-miR-21-5p " miRNA Mus musculus 19266099 Microvesicle Embryonic stem cell qRT-PCR "Figure 5: ESMVs contain miRNAs. The relative abundance of several miRNAs in ESMVs compared with ESCs was determined by real time quantitative RT-PCR. The miRNAs tested include miR-16 (lane 1), miR-21 (lane 2), miR-22 (lane 3), miR-290 (lane 4), miR-291-3p (lane 5), miR-292-3p (lane 6), miR-294 (lane 7), miR-295 (lane 8), and the small nuclear RNA, RNU6b (lane 9). Data are collected from Figure 5. " RLID00031096 MIMAT0000531 mmu-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000531 mmu-miR-22 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031097 MIMAT0000531 mmu-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000531 mmu-miR-22 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00031098 MIMAT0000531 mmu-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000531 mmu-miR-22 miRNA Mus musculus 21862971 Nucleus Liver cell Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031099 MIMAT0000531 mmu-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000531 mmu-miR-22 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031100 MIMAT0000531 mmu-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000531 mmu-miR-22 miRNA Mus musculus 19266099 Microvesicle Embryonic stem cell qRT-PCR "Figure 5: ESMVs contain miRNAs. The relative abundance of several miRNAs in ESMVs compared with ESCs was determined by real time quantitative RT-PCR. The miRNAs tested include miR-16 (lane 1), miR-21 (lane 2), miR-22 (lane 3), miR-290 (lane 4), miR-291-3p (lane 5), miR-292-3p (lane 6), miR-294 (lane 7), miR-295 (lane 8), and the small nuclear RNA, RNU6b (lane 9). Data are collected from Figure 5. " RLID00031101 MIMAT0000532 mmu-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000532 mmu-miR-23a miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00031102 MIMAT0000532 mmu-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000532 mmu-miR-23a miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031103 MIMAT0000532 mmu-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000532 mmu-miR-23a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031104 MIMAT0000532 mmu-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000532 mmu-miR-23a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031105 MIMAT0000532 mmu-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000532 mmu-miR-23a miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031106 MIMAT0000533 mmu-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000533 mmu-miR-26a miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031107 MIMAT0000533 mmu-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000533 mmu-miR-26a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031108 MIMAT0000533 mmu-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000533 mmu-miR-26a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031109 MIMAT0000533 mmu-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000533 mmu-miR-26a miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031110 MIMAT0000534 mmu-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000534 mmu-miR-26b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031111 MIMAT0000534 mmu-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000534 mmu-miR-26b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031112 MIMAT0000534 mmu-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000534 mmu-miR-26b miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031113 MIMAT0000535 mmu-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000535 mmu-miR-29a miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00031114 MIMAT0000535 mmu-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000535 mmu-miR-29a miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031115 MIMAT0000535 mmu-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000535 mmu-miR-29a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031116 MIMAT0000535 mmu-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000535 mmu-miR-29a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031117 MIMAT0000535 mmu-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000535 mmu-miR-29a miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00031118 MIMAT0000535 mmu-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000535 mmu-miR-29a miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031119 MIMAT0000535 mmu-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000535 mmu-miR-29a miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00031120 MIMAT0000536 mmu-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000536 mmu-miR-29c miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031121 MIMAT0000536 mmu-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000536 mmu-miR-29c miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031122 MIMAT0000536 mmu-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000536 mmu-miR-29c miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00031123 MIMAT0000536 mmu-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000536 mmu-miR-29c miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031124 MIMAT0000536 mmu-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000536 mmu-miR-29c miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031125 MIMAT0000537 mmu-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000537 mmu-miR-27a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031126 MIMAT0000537 mmu-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000537 mmu-miR-27a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031127 MIMAT0000537 mmu-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000537 mmu-miR-27a miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031128 MIMAT0000538 mmu-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000538 mmu-miR-31 miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00031129 MIMAT0000538 mmu-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000538 mmu-miR-31 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031130 MIMAT0000538 mmu-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000538 mmu-miR-31 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031131 MIMAT0000538 mmu-miR-31-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000538 mmu-miR-31 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031132 MIMAT0000539 mmu-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000539 "mmu-miR-92, mmu-miR-92a " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031133 MIMAT0000539 mmu-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000539 "mmu-miR-92, mmu-miR-92a " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031134 MIMAT0000539 mmu-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000539 "mmu-miR-92, mmu-miR-92a " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031135 MIMAT0000540 mmu-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000540 mmu-miR-93 miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00031136 MIMAT0000540 mmu-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000540 mmu-miR-93 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031137 MIMAT0000540 mmu-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000540 mmu-miR-93 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031138 MIMAT0000542 mmu-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000542 mmu-miR-34a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031139 MIMAT0000544 mmu-miR-129-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000544 mmu-miR-129-3p miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031140 MIMAT0000545 mmu-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000545 mmu-miR-98 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031141 MIMAT0000545 mmu-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000545 mmu-miR-98 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031142 MIMAT0000546 mmu-miR-103-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000546 mmu-miR-103 miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00031143 MIMAT0000546 mmu-miR-103-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000546 mmu-miR-103 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031144 MIMAT0000546 mmu-miR-103-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000546 mmu-miR-103 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031145 MIMAT0000546 mmu-miR-103-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000546 mmu-miR-103 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00031146 MIMAT0000547 rno-miR-322-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000547 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031147 MIMAT0000547 rno-miR-322-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000547 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00031148 MIMAT0000548 mmu-miR-322-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000548 "mmu-miR-322-5p, mmu-miR-424, mmu-miR-322 " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031149 MIMAT0000548 mmu-miR-322-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000548 "mmu-miR-322-5p, mmu-miR-424, mmu-miR-322 " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031150 MIMAT0000548 mmu-miR-322-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000548 "mmu-miR-322-5p, mmu-miR-424, mmu-miR-322 " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031151 MIMAT0000548 mmu-miR-322-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000548 "mmu-miR-322-5p, mmu-miR-424, mmu-miR-322 " miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031152 MIMAT0000549 mmu-miR-322-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000549 "mmu-miR-322-3p, mmu-miR-322, mmu-miR-322* " miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00031153 MIMAT0000549 mmu-miR-322-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000549 "mmu-miR-322-3p, mmu-miR-322, mmu-miR-322* " miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031154 MIMAT0000550 rno-miR-323-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000550 rno-miR-323 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00031155 MIMAT0000550 rno-miR-323-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000550 rno-miR-323 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00031156 MIMAT0000551 mmu-miR-323-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000551 mmu-miR-323 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031157 MIMAT0000552 rno-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000552 "rno-miR-301, rno-miR-301a " miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031158 MIMAT0000552 rno-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000552 "rno-miR-301, rno-miR-301a " miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00031159 MIMAT0000552 rno-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000552 "rno-miR-301, rno-miR-301a " miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031160 MIMAT0000552 rno-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000552 "rno-miR-301, rno-miR-301a " miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031161 MIMAT0000553 rno-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000553 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00031162 MIMAT0000554 rno-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000554 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00031163 MIMAT0000555 mmu-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000555 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031164 MIMAT0000555 mmu-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000555 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031165 MIMAT0000556 mmu-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000556 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031166 MIMAT0000556 mmu-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000556 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031167 MIMAT0000556 mmu-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000556 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031168 MIMAT0000556 mmu-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000556 miRNA Mus musculus 23897634 Axon Neuron ball cultures Fluorescence in situ hybridization "We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)].We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)]. Data are collected from Table 1. " RLID00031169 MIMAT0000557 rno-miR-325-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000557 rno-miR-325 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00031170 MIMAT0000558 mmu-miR-325-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000558 "mmu-miR-325, mmu-miR-325* " miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031171 MIMAT0000559 mmu-miR-326-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000559 mmu-miR-326 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031172 MIMAT0000559 mmu-miR-326-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000559 mmu-miR-326 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031173 MIMAT0000560 rno-miR-326-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000560 rno-miR-326 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00031174 MIMAT0000560 rno-miR-326-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000560 rno-miR-326 miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031175 MIMAT0000561 rno-miR-327 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000561 miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031176 MIMAT0000561 rno-miR-327 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000561 miRNA Rattus norvegicus 24553149 Circulating Plasma qRT-PCR|Microarray "Microarray assay results showed a total of 36 differentially-expressed miRNAs, among which 15 miRNAs were considered as aberrantly expressed with a more than 2-fold change when calculating the ratio of fluorescence intense between the 2 groups. The elevated miRNAs included miR-290, miR-874, miR-292-5p, miR-327, miR-374, miR-98, miR-352, miR-132, miR-146b, and miR-196a. The down-regulated miRNAs included miR-145, miR-329, miR-375, miR-140*, and miR-29a. Validation of microarray assay by qRT-PCR showed similar results and the ΔΔCt value compared to the sham group are shown in Figure 1. " RLID00031177 MIMAT0000562 rno-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000562 rno-let-7d miRNA Rattus norvegicus 17592044 Dendrite Hippocampus In situ hybridization|RT-PCR "Dendritic miRNAs appeared punctate by in situ hybridization (Fig. 4), a pattern typical of many dendritic mRNA populations. Fogure 4: miRNAs appear granular by in situ hybridization in cultured hippocampal neurons. (A) rno-miR-26a. (B) High power of rno-miR-26a puncta; (C) rno-miR-92; (D) rno-let-7d; and (E) rno-124a. Images were acquired using a confocal microscope. (A,C,D,E) Scale bar, 50 um; (B) scale bar, 5 um. " RLID00031178 MIMAT0000564 rno-miR-328a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000564 "rno-miR-328, rno-miR-328a " miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00031179 MIMAT0000565 mmu-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000565 mmu-miR-328 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031180 MIMAT0000565 mmu-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000565 mmu-miR-328 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031181 MIMAT0000565 mmu-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000565 mmu-miR-328 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031182 MIMAT0000565 mmu-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000565 mmu-miR-328 miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00031183 MIMAT0000565 mmu-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000565 mmu-miR-328 miRNA Mus musculus 23897634 Cell body Neuron ball cultures Fluorescence in situ hybridization Data are collected from Table 2: Cell Body-Enriched miRNAs. RLID00031184 MIMAT0000566 rno-miR-329-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000566 rno-miR-329 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031185 MIMAT0000566 rno-miR-329-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000566 rno-miR-329 miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031186 MIMAT0000566 rno-miR-329-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000566 rno-miR-329 miRNA Rattus norvegicus 24553149 Circulating Plasma qRT-PCR|Microarray "Microarray assay results showed a total of 36 differentially-expressed miRNAs, among which 15 miRNAs were considered as aberrantly expressed with a more than 2-fold change when calculating the ratio of fluorescence intense between the 2 groups. The elevated miRNAs included miR-290, miR-874, miR-292-5p, miR-327, miR-374, miR-98, miR-352, miR-132, miR-146b, and miR-196a. The down-regulated miRNAs included miR-145, miR-329, miR-375, miR-140*, and miR-29a. Validation of microarray assay by qRT-PCR showed similar results and the ΔΔCt value compared to the sham group are shown in Figure 1. " RLID00031187 MIMAT0000566 rno-miR-329-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000566 rno-miR-329 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00031188 MIMAT0000567 mmu-miR-329-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000567 mmu-miR-329 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031189 MIMAT0000570 rno-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000570 rno-miR-331 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00031190 MIMAT0000571 mmu-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000571 mmu-miR-331 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031191 MIMAT0000571 mmu-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000571 mmu-miR-331 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031192 MIMAT0000573 rno-miR-140-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000573 rno-miR-140 miRNA Rattus norvegicus 19106625 Mitochondrion livers qRT-PCR|Microarray "To further define whether the miRNAs were present within the mitochondria, we used deoxycholic acid (DCA) to induce opening of the mitochondrial megapore channel33 and induction of the mitochondria permeability transition (MPT) in the isolated mitochondria.This disruption of mitochondrial integrity resulted in a significant loss of miRNAs by RT-PCR in the DCA treated mitochondria relative to the control vehicle group. The release of miR-130a and b, miR-320 and miR-494 was about 50% and that of miR-140 almost 80%. " RLID00031193 MIMAT0000574 rno-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000574 rno-miR-140* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00031194 MIMAT0000574 rno-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000574 rno-miR-140* miRNA Rattus norvegicus 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00031195 MIMAT0000575 rno-miR-335 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000575 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00031196 MIMAT0000578 mmu-miR-337-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000578 mmu-miR-337 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031197 MIMAT0000578 mmu-miR-337-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000578 mmu-miR-337 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031198 MIMAT0000579 rno-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000579 rno-miR-148b miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031199 MIMAT0000580 mmu-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000580 mmu-miR-148b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031200 MIMAT0000580 mmu-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000580 mmu-miR-148b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031201 MIMAT0000582 mmu-miR-338-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000582 mmu-miR-338 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031202 MIMAT0000582 mmu-miR-338-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000582 mmu-miR-338 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031203 MIMAT0000582 mmu-miR-338-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000582 mmu-miR-338 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031204 MIMAT0000584 mmu-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000584 mmu-miR-339 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031205 MIMAT0000584 mmu-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000584 mmu-miR-339 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031206 MIMAT0000584 mmu-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000584 mmu-miR-339 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031207 MIMAT0000584 mmu-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000584 mmu-miR-339 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Nevertheless, the qRT-PCR method did confirm that both miR-339 and miR-350 were significantly SYN-enriched " RLID00031208 MIMAT0000584 mmu-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000584 mmu-miR-339 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Synaptosomes were extracted with non-ionic detergent and measurements were made of the soluble extract vs. the insoluble residue (i.e., the PSD fraction). As shown in fig.10b, the microRNA precursors were all predominantly associated with the PSD fractionIn contrast, the mature microRNAs were predominantly detected in the Triton-soluble fraction (fig. 7b). Data are collected from Figure 7B.. " RLID00031209 MIMAT0000584 mmu-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000584 mmu-miR-339 miRNA Mus musculus 18410515 Synapse ForeBrain qRT-PCR|Microarray Table 2: Enrichment ratios (synaptoneurosomes/total homogenate) of selected mature microRNAs measured by real-time qRT-PCR. Data are collected from Table 2. RLID00031210 MIMAT0000584 mmu-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000584 mmu-miR-339 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031211 MIMAT0000586 mmu-miR-340-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000586 mmu-miR-340 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031212 MIMAT0000586 mmu-miR-340-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000586 mmu-miR-340 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031213 MIMAT0000586 mmu-miR-340-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000586 mmu-miR-340 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031214 MIMAT0000588 mmu-miR-341-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000588 mmu-miR-341 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031215 MIMAT0000589 rno-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000589 rno-miR-342 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00031216 MIMAT0000590 mmu-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000590 mmu-miR-342 miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00031217 MIMAT0000590 mmu-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000590 mmu-miR-342 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031218 MIMAT0000590 mmu-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000590 mmu-miR-342 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031219 MIMAT0000590 mmu-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000590 miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00031220 MIMAT0000592 rno-miR-344a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000592 "rno-miR-344, rno-miR-344-3p " miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00031221 MIMAT0000593 mmu-miR-344-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000593 mmu-miR-344 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031222 MIMAT0000593 mmu-miR-344-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000593 mmu-miR-344 miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00031223 MIMAT0000595 mmu-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000595 mmu-miR-345 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031224 MIMAT0000595 mmu-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000595 mmu-miR-345 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031225 MIMAT0000596 rno-miR-346 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000596 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00031226 MIMAT0000597 mmu-miR-346-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000597 mmu-miR-346 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031227 MIMAT0000598 rno-miR-347 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000598 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031228 MIMAT0000598 rno-miR-347 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000598 miRNA Rattus norvegicus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031229 MIMAT0000600 rno-miR-129-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000600 rno-miR-129 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031230 MIMAT0000602 rno-miR-20a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000602 "rno-miR-20, rno-miR-20a " miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031231 MIMAT0000605 mmu-miR-350-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000605 mmu-miR-350 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031232 MIMAT0000605 mmu-miR-350-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000605 mmu-miR-350 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031233 MIMAT0000605 mmu-miR-350-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000605 mmu-miR-350 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031234 MIMAT0000605 mmu-miR-350-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000605 mmu-miR-350 miRNA Mus musculus 18410515 Synapse Forebrains qRT-PCR|Microarray "Nevertheless, the qRT-PCR method did confirm that both miR-339 and miR-350 were significantly SYN-enriched " RLID00031235 MIMAT0000605 mmu-miR-350-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000605 mmu-miR-350 miRNA Mus musculus 18410515 Synapse ForeBrain qRT-PCR|Microarray Table 2: Enrichment ratios (synaptoneurosomes/total homogenate) of selected mature microRNAs measured by real-time qRT-PCR. Data are collected from Table 2. RLID00031236 MIMAT0000605 mmu-miR-350-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000605 mmu-miR-350 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031237 MIMAT0000606 rno-miR-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000606 "rno-miR-7, rno-miR-7a " miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00031238 MIMAT0000606 rno-miR-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000606 "rno-miR-7, rno-miR-7a " miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031239 MIMAT0000606 rno-miR-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000606 "rno-miR-7, rno-miR-7a " miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031240 MIMAT0000607 rno-miR-7a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000607 "rno-miR-7*, rno-miR-7a*, rno-miR-7a-1* " miRNA Rattus norvegicus 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031241 MIMAT0000608 rno-miR-351-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000608 miRNA Rattus norvegicus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031242 MIMAT0000608 rno-miR-351-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000608 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00031243 MIMAT0000608 rno-miR-351-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000608 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Five miRNAs, miR-340-5p, miR-351, miR-494, miR-664, and let-7e, were significantly concentrated (two- to eightfold) in the nucleolus compared with the nucleoplasm and/or the cytoplasm (Fig. 2A; Supplemental Table 1). " RLID00031244 MIMAT0000609 mmu-miR-351-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000609 mmu-miR-351 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031245 MIMAT0000609 mmu-miR-351-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000609 mmu-miR-351 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031246 MIMAT0000609 mmu-miR-351-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000609 mmu-miR-351 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031247 MIMAT0000609 mmu-miR-351-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000609 mmu-miR-351 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00031248 MIMAT0000609 mmu-miR-351-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000609 mmu-miR-351 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031249 MIMAT0000610 rno-miR-352 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000610 miRNA Rattus norvegicus 24553149 Circulating Plasma qRT-PCR|Microarray "Microarray assay results showed a total of 36 differentially-expressed miRNAs, among which 15 miRNAs were considered as aberrantly expressed with a more than 2-fold change when calculating the ratio of fluorescence intense between the 2 groups. The elevated miRNAs included miR-290, miR-874, miR-292-5p, miR-327, miR-374, miR-98, miR-352, miR-132, miR-146b, and miR-196a. The down-regulated miRNAs included miR-145, miR-329, miR-375, miR-140*, and miR-29a. Validation of microarray assay by qRT-PCR showed similar results and the ΔΔCt value compared to the sham group are shown in Figure 1. " RLID00031250 MIMAT0000612 mmu-miR-135b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000612 mmu-miR-135b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031251 MIMAT0000613 rno-miR-151-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000613 "rno-miR-151*, rno-miR-151 " miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00031252 MIMAT0000613 rno-miR-151-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000613 "rno-miR-151*, rno-miR-151 " miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00031253 MIMAT0000616 mmu-miR-101b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000616 mmu-miR-101b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031254 MIMAT0000616 mmu-miR-101b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000616 mmu-miR-101b miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00031255 MIMAT0000616 mmu-miR-101b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000616 mmu-miR-101b miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031256 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 24259014 Circulating Serum Microarray "Elevated Serum Level of MicroRNA (miRNA)-200c nd miRNA-371-5p in Children with Kawasaki Disease. Two miRNAs, miR-200c and miR-371-5p, were differentially expressed between children with and without KD (Fig.2). Both miRNAs were significantly upregulated in the KD group compared with the control group (p=0.032 in both). " RLID00031257 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031258 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031259 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00031260 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031261 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 21601258 Exosome Ascites qRT-PCR "Fig. 2. Biochemical marker analysis of exosomes. (A) Exosomes isolated from ascites or pleural effusions of tumor or LC patients were analyzed using the indi cated mAb followed by peroxidase-conjugated secondary antibody and ECL detection. 10 μ g exosomes were applied per lane. Note that HSP70, ADAM10, Annexin-1 and CD9 are considered as general exosome markers. HLA-DR was used as a marker for immune cell derived exosomes. Note that in BrCa patients #9�4 samples were derived from pleural effusions and #15 and 16 were from ascites. (B) The content of the indicated miRNAs was quantified by real-time RT-PCR in exosomes from ascites of OvCa (n=10) or LC patients (n=6) or BrCa pleural effusions (n=7). Note, that low Ct values re fl ect high expression levels of the respective miRNA. P-values in the fi gure are indicated as follows: * < 0.05, ** < 0.01 *** < 0.001. Data are collected from Figure 2. " RLID00031262 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031263 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031264 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031265 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031266 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031267 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00031268 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031269 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00031270 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00031271 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031272 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031273 MIMAT0000617 hsa-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000617 hsa-miR-200c miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031274 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 18954897 Circulating Serum qRT-PCR Fig. 2. Median fold-change differences in differentially expressed miRNAs between patient and control serum. Data are collected from Figure 2. RLID00031275 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 21398193 Circulating Blood qRT-PCR "Figure 3: Elevated levels of RNA and miRs in blood of lung cancer patients. The box plot shows the significantly different amounts of RNA, miR10b, miR34a, miR141 and miR155 which circulate in blood of healthy individuals (n = 28), patients with benign lung disease (n = 7) and patients with lung cancer (n = 35). " RLID00031276 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031277 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031278 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031279 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 19289371 Exosome Plasma Microarray Figure 1: Intensities for specific microRNAs derived from the tumor and exosomes isolated from the plasma of the patients. Data are collected from Figure 1. RLID00031280 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031281 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031282 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00031283 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 22884882 Circulating Plasma Microarray|qRT-PCR "To explore a potential novel biomarker, we examined the cellular and plasma miRNA profiles in adult T-cell leukemia (ATL) characterized by diverse clinical features. Methods and results : Using CD4-positive cells isolated from 2 non-infected healthy individuals, 3 chronic ATL patients and 3 acute ATL patients, cellular miRNAs were profiled by microarray. The microarray screened 5 miRNAs namely miR-155, let-7g, miR-126, miR-130a and let-7b because of the large difference in their expression in diseased vs. that of healthy controls. " RLID00031284 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031285 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 23559272 Circulating Serum Microarray "Using microarray-based expression profiling followed by real-time quantitative polymerase chain reaction validation, we compared the levels of a series of circulating miRNAs (miR-21, miR-155, miR-182, and miR-197) in serum from patients with lung cancer (n = 65), pulmonary tuberculosis (n = 29), pneumonia (n = 29), and transudate (n = 16) compared with matched healthy controls (n = 37). " RLID00031286 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031287 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00031288 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031289 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031290 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031291 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031292 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031293 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031294 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031295 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031296 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 22529849 Exosome Kidney cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031297 MIMAT0000646 hsa-miR-155-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000646 hsa-miR-155 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00031298 MIMAT0000647 mmu-miR-107-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000647 mmu-miR-107 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031299 MIMAT0000647 mmu-miR-107-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000647 mmu-miR-107 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031300 MIMAT0000647 mmu-miR-107-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000647 mmu-miR-107 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00031301 MIMAT0000648 mmu-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000648 mmu-miR-10a miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031302 MIMAT0000648 mmu-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000648 mmu-miR-10a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031303 MIMAT0000648 mmu-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000648 mmu-miR-10a miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031304 MIMAT0000648 mmu-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000648 mmu-miR-10a miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00031305 MIMAT0000649 mmu-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000649 "mmu-miR-17-5p, mmu-miR-17 " miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031306 MIMAT0000649 mmu-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000649 "mmu-miR-17-5p, mmu-miR-17 " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031307 MIMAT0000649 mmu-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000649 "mmu-miR-17-5p, mmu-miR-17 " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031308 MIMAT0000649 mmu-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000649 "mmu-miR-17-5p, mmu-miR-17 " miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00031309 MIMAT0000649 mmu-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000649 "mmu-miR-17-5p, mmu-miR-17 " miRNA Mus musculus 23897634 Axon Neuron ball cultures Fluorescence in situ hybridization "We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)].We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)]. Data are collected from Table 1. " RLID00031310 MIMAT0000650 mmu-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000650 "mmu-miR-17-3p, mmu-miR-17* " miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031311 MIMAT0000650 mmu-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000650 "mmu-miR-17-3p, mmu-miR-17* " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031312 MIMAT0000651 mmu-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000651 mmu-miR-19a miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031313 MIMAT0000651 mmu-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000651 mmu-miR-19a miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031314 MIMAT0000651 mmu-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000651 mmu-miR-19a miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031315 MIMAT0000652 mmu-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000652 mmu-miR-25 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031316 MIMAT0000652 mmu-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000652 mmu-miR-25 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031317 MIMAT0000652 mmu-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000652 mmu-miR-25 miRNA Mus musculus 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00031318 MIMAT0000652 mmu-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000652 mmu-miR-25 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031319 MIMAT0000653 mmu-miR-28a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000653 "mmu-miR-28, mmu-miR-28-5p " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031320 MIMAT0000653 mmu-miR-28a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000653 "mmu-miR-28, mmu-miR-28-5p " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031321 MIMAT0000653 mmu-miR-28a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000653 "mmu-miR-28, mmu-miR-28-5p " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031322 MIMAT0000654 mmu-miR-32-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000654 mmu-miR-32 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031323 MIMAT0000655 mmu-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000655 mmu-miR-100 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031324 MIMAT0000655 mmu-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000655 mmu-miR-100 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031325 MIMAT0000656 mmu-miR-139-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000656 mmu-miR-139 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031326 MIMAT0000656 mmu-miR-139-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000656 mmu-miR-139 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031327 MIMAT0000657 mmu-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000657 mmu-miR-200c miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031328 MIMAT0000657 mmu-miR-200c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000657 mmu-miR-200c miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031329 MIMAT0000658 mmu-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000658 mmu-miR-210 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031330 MIMAT0000658 mmu-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000658 mmu-miR-210 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00031331 MIMAT0000658 mmu-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000658 mmu-miR-210 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031332 MIMAT0000659 mmu-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000659 mmu-miR-212 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031333 MIMAT0000659 mmu-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000659 mmu-miR-212 miRNA Mus musculus 23897634 Axon Neuron ball cultures Fluorescence in situ hybridization "We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)].We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)]. Data are collected from Table 1. " RLID00031334 MIMAT0000660 mmu-miR-181a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000660 "mmu-miR-213, mmu-miR-181a*, mmu-miR-181a-1* " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031335 MIMAT0000660 mmu-miR-181a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000660 "mmu-miR-213, mmu-miR-181a*, mmu-miR-181a-1* " miRNA Mus musculus 23897634 Axon Neuron ball cultures Fluorescence in situ hybridization "We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)].We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)]. Data are collected from Table 1. " RLID00031336 MIMAT0000661 mmu-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000661 mmu-miR-214 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031337 MIMAT0000661 mmu-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000661 mmu-miR-214 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00031338 MIMAT0000661 mmu-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000661 mmu-miR-214 miRNA Mus musculus 18204908 Cytoplasm Spermatocyte In situ hybridization|Microarray "Hybridization signals with all miRNA probes tested localized to the Sertoli cells (Figure 5A), with some also present in the cytoplasm of the germ cells (miR-214) and others (miR-24) having a distinct localization pattern in the nuclei of spermatocytes (Figure 5A). " RLID00031339 MIMAT0000661 mmu-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000661 mmu-miR-214 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031340 MIMAT0000663 mmu-miR-218-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000663 mmu-miR-218 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031341 MIMAT0000663 mmu-miR-218-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000663 mmu-miR-218 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031342 MIMAT0000663 mmu-miR-218-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000663 mmu-miR-218 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031343 MIMAT0000663 mmu-miR-218-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000663 mmu-miR-218 miRNA Mus musculus 23897634 Cell body Neuron ball cultures Fluorescence in situ hybridization Data are collected from Table 2: Cell Body-Enriched miRNAs. RLID00031344 MIMAT0000664 mmu-miR-219a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000664 mmu-miR-219 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031345 MIMAT0000664 mmu-miR-219a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000664 mmu-miR-219 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031346 MIMAT0000664 mmu-miR-219a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000664 mmu-miR-219 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031347 MIMAT0000664 mmu-miR-219a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000664 mmu-miR-219 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031348 MIMAT0000665 mmu-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000665 mmu-miR-223 miRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "We found strong concordance when ranking the different RNAs based on their abundance in the shuttle RNA. We calculated the correlation between the (ranked) small shuttle RNA sequencing data of the replicates. A high correlation was observed between the replicates (Pearson’s correlation 0.97, P-value <2.2e-16; Supplementary Figure S1). Data are collected from Figure S1. " RLID00031349 MIMAT0000665 mmu-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000665 mmu-miR-223 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031350 MIMAT0000665 mmu-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000665 mmu-miR-223 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031351 MIMAT0000665 mmu-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000665 mmu-miR-223 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00031352 MIMAT0000665 mmu-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000665 mmu-miR-223 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031353 MIMAT0000665 mmu-miR-223-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000665 mmu-miR-223 miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00031354 MIMAT0000666 mmu-miR-320-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000666 mmu-miR-320 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031355 MIMAT0000666 mmu-miR-320-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000666 mmu-miR-320 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031356 MIMAT0000666 mmu-miR-320-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000666 mmu-miR-320 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031357 MIMAT0000666 mmu-miR-320-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000666 mmu-miR-320 miRNA Mus musculus 18204908 Nucleolus Spermatocyte In situ hybridization|Microarray "FISH analysis of piRNA localization revealed a strong signal in the nucleolus of Sertoli cells, in agreement with our observed miRNA pattern. The images of the two piRNAs shown in Figure 6S are essentially identical to all piRNAs tested. This nucleolar localization was abolished in MIWI-null testis (Figure 6C; Sertoli cell, insert, yellow arrow). The effect of MIWI deletion is surprising since expression of MIWI protein was reported in the cytoplasm of spermatocytes and spermatids but not Sertoli cells (Deng & Lin 2002, Kotaja et al. 2006). It is possible that the greater levels of expression in spermatocytes and spermatids have obscured visual- ization of MIWI staining in the Sertoli cells where MIWI could be responsible for localization of piRNAs to the nucleolus and possibly their processing. In meiotic spreads, only piR-7 and piR-17005 showed strong localization to the dense body, chromosome cores and possibly telomeres, while the other three (piR-17037, 17043, 17080) showed very weak or no association (Figure 6D). MIWI deletion did not affect piRNAs localization in the meiotic nucleus. " RLID00031358 MIMAT0000666 mmu-miR-320-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000666 mmu-miR-320 miRNA Mus musculus 18204908 Nucleus Spermatocyte In situ hybridization|Microarray "FISH analysis of piRNA localization revealed a strong signal in the nucleolus of Sertoli cells, in agreement with our observed miRNA pattern. The images of the two piRNAs shown in Figure 6S are essentially identical to all piRNAs tested. This nucleolar localization was abolished in MIWI-null testis (Figure 6C; Sertoli cell, insert, yellow arrow). The effect of MIWI deletion is surprising since expression of MIWI protein was reported in the cytoplasm of spermatocytes and spermatids but not Sertoli cells (Deng & Lin 2002, Kotaja et al. 2006). It is possible that the greater levels of expression in spermatocytes and spermatids have obscured visual- ization of MIWI staining in the Sertoli cells where MIWI could be responsible for localization of piRNAs to the nucleolus and possibly their processing. In meiotic spreads, only piR-7 and piR-17005 showed strong localization to the dense body, chromosome cores and possibly telomeres, while the other three (piR-17037, 17043, 17080) showed very weak or no association (Figure 6D). MIWI deletion did not affect piRNAs localization in the meiotic nucleus. " RLID00031359 MIMAT0000666 mmu-miR-320-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000666 mmu-miR-320 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031360 MIMAT0000667 mmu-miR-33-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000667 mmu-miR-33 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031361 MIMAT0000669 mmu-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000669 mmu-miR-221 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031362 MIMAT0000669 mmu-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000669 mmu-miR-221 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031363 MIMAT0000669 mmu-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000669 mmu-miR-221 miRNA Mus musculus 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00031364 MIMAT0000669 mmu-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000669 mmu-miR-221 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031365 MIMAT0000670 mmu-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000670 mmu-miR-222 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031366 MIMAT0000670 mmu-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000670 mmu-miR-222 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031367 MIMAT0000670 mmu-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000670 mmu-miR-222 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031368 MIMAT0000670 mmu-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000670 mmu-miR-222 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031369 MIMAT0000671 mmu-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000671 mmu-miR-224 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031370 MIMAT0000671 mmu-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000671 mmu-miR-224 miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00031371 MIMAT0000673 mmu-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000673 mmu-miR-181b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031372 MIMAT0000673 mmu-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000673 mmu-miR-181b miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00031373 MIMAT0000673 mmu-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000673 mmu-miR-181b miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00031374 MIMAT0000674 mmu-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000674 mmu-miR-181c miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031375 MIMAT0000674 mmu-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000674 mmu-miR-181c miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031376 MIMAT0000674 mmu-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000674 mmu-miR-181c miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031377 MIMAT0000677 mmu-miR-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000677 "mmu-miR-7, mmu-miR-7a " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031378 MIMAT0000677 mmu-miR-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000677 "mmu-miR-7, mmu-miR-7a " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031379 MIMAT0000678 mmu-miR-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000678 mmu-miR-7b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031380 MIMAT0000678 mmu-miR-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000678 mmu-miR-7b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031381 MIMAT0000678 mmu-miR-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000678 mmu-miR-7b miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031382 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031383 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031384 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 23805240 Circulating Plasma qRT-PCR "Circulating microRNAs as a Fingerprint for Liver Cirrhosis. Our study demonstrated that the combined detection of miR-106b and miR-181b has a considerable clinical value to diagnose patients with liver cirrhosis, especially those at early stage. " RLID00031385 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 24456939 Circulating Plasma - "In gastric cancer, several circulating miRNAs have been studied as potential diagnostic biomarkers by evaluating their amount in serum, plasma and gastric juice (Table 2). Data are collected from Table 2. " RLID00031386 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031387 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00031388 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031389 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00031390 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031391 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031392 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031393 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031394 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031395 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00031396 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00031397 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00031398 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031399 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031400 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00031401 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031402 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00031403 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 25165030 Circulating Serum RT-PCR "Although serum microRNAs (miRNAs) play essential roles in the diagnosis of various diseases, little is known about circulating miRNAs in the aging process. Solexa sequencing demonstrated 17 markedly altered miRNAs in the aging process. Quantitative reversn-PCR analysis identified five downregulated miRNAs (miR-29b, miR-106b, miR-130b, miR-142-5p, and miR-340) and three upregulated miRNAs (miR-92a, miR-222, and miR-375) with age. " RLID00031404 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00031405 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031406 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031407 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031408 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031409 MIMAT0000680 hsa-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000680 hsa-miR-106b miRNA Homo sapiens 25126405 Circulating Serum qRT-PCR "Circulating miRNAs in the serum and plasma are remarkably stable and are suggested to have promise as noninvasive biomarkers for neurological and neurodevelopmental disorders. Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated. " RLID00031410 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 23056289 Circulating Serum qRT-PCR "Circulating miR-17, miR-20a, miR-29c, and miR-223 combined as non-invasive biomarkers in nasopharyngeal carcinoma. " RLID00031411 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031412 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031413 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031414 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031415 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00031416 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031417 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031418 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00031419 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031420 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031421 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031422 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031423 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00031424 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031425 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031426 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031427 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031428 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031429 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031430 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031431 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031432 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031433 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00031434 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00031435 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031436 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031437 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031438 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00031439 MIMAT0000681 hsa-miR-29c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000681 hsa-miR-29c miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00031440 MIMAT0000682 hsa-miR-200a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000682 hsa-miR-200a miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031441 MIMAT0000682 hsa-miR-200a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000682 hsa-miR-200a miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031442 MIMAT0000682 hsa-miR-200a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000682 hsa-miR-200a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031443 MIMAT0000682 hsa-miR-200a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000682 hsa-miR-200a miRNA Homo sapiens 21601258 Exosome Ascites qRT-PCR "Fig. 2. Biochemical marker analysis of exosomes. (A) Exosomes isolated from ascites or pleural effusions of tumor or LC patients were analyzed using the indi cated mAb followed by peroxidase-conjugated secondary antibody and ECL detection. 10 μ g exosomes were applied per lane. Note that HSP70, ADAM10, Annexin-1 and CD9 are considered as general exosome markers. HLA-DR was used as a marker for immune cell derived exosomes. Note that in BrCa patients #9�4 samples were derived from pleural effusions and #15 and 16 were from ascites. (B) The content of the indicated miRNAs was quantified by real-time RT-PCR in exosomes from ascites of OvCa (n=10) or LC patients (n=6) or BrCa pleural effusions (n=7). Note, that low Ct values re fl ect high expression levels of the respective miRNA. P-values in the fi gure are indicated as follows: * < 0.05, ** < 0.01 *** < 0.001. Data are collected from Figure 2. " RLID00031444 MIMAT0000682 hsa-miR-200a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000682 hsa-miR-200a miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00031445 MIMAT0000682 hsa-miR-200a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000682 hsa-miR-200a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031446 MIMAT0000682 hsa-miR-200a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000682 hsa-miR-200a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031447 MIMAT0000682 hsa-miR-200a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000682 hsa-miR-200a miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031448 MIMAT0000682 hsa-miR-200a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000682 hsa-miR-200a miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031449 MIMAT0000682 hsa-miR-200a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000682 hsa-miR-200a miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00031450 MIMAT0000682 hsa-miR-200a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000682 hsa-miR-200a miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031451 MIMAT0000682 hsa-miR-200a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000682 hsa-miR-200a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031452 MIMAT0000682 hsa-miR-200a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000682 hsa-miR-200a miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031453 MIMAT0000683 hsa-miR-302a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000683 hsa-miR-302a* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031454 MIMAT0000683 hsa-miR-302a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000683 hsa-miR-302a* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031455 MIMAT0000684 hsa-miR-302a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000684 hsa-miR-302a miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031456 MIMAT0000684 hsa-miR-302a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000684 hsa-miR-302a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031457 MIMAT0000684 hsa-miR-302a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000684 hsa-miR-302a miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00031458 MIMAT0000685 hsa-miR-34b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000685 "hsa-miR-34b, hsa-miR-34b* " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031459 MIMAT0000685 hsa-miR-34b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000685 "hsa-miR-34b, hsa-miR-34b* " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031460 MIMAT0000685 hsa-miR-34b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000685 "hsa-miR-34b, hsa-miR-34b* " miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031461 MIMAT0000685 hsa-miR-34b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000685 "hsa-miR-34b, hsa-miR-34b* " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031462 MIMAT0000685 hsa-miR-34b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000685 "hsa-miR-34b, hsa-miR-34b* " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031463 MIMAT0000685 hsa-miR-34b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000685 "hsa-miR-34b, hsa-miR-34b* " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031464 MIMAT0000685 hsa-miR-34b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000685 "hsa-miR-34b, hsa-miR-34b* " miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00031465 MIMAT0000685 hsa-miR-34b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000685 "hsa-miR-34b, hsa-miR-34b* " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031466 MIMAT0000686 hsa-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000686 hsa-miR-34c miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 1: Ten miRNAs differentially expressed in both tumor tissue and serum. Data are collected from Table 1. RLID00031467 MIMAT0000686 hsa-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000686 hsa-miR-34c miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031468 MIMAT0000686 hsa-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000686 hsa-miR-34c miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031469 MIMAT0000686 hsa-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000686 hsa-miR-34c miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031470 MIMAT0000686 hsa-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000686 hsa-miR-34c miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031471 MIMAT0000686 hsa-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000686 hsa-miR-34c miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031472 MIMAT0000686 hsa-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000686 hsa-miR-34c miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031473 MIMAT0000686 hsa-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000686 hsa-miR-34c miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031474 MIMAT0000686 hsa-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000686 hsa-miR-34c miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031475 MIMAT0000686 hsa-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000686 hsa-miR-34c miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00031476 MIMAT0000686 hsa-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000686 hsa-miR-34c miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031477 MIMAT0000687 hsa-miR-299-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000687 "hsa-miR-299, hsa-miR-299-5p " miRNA Homo sapiens 21505438 Exosome Primary dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031478 MIMAT0000687 hsa-miR-299-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000687 "hsa-miR-299, hsa-miR-299-5p " miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031479 MIMAT0000687 hsa-miR-299-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000687 "hsa-miR-299, hsa-miR-299-5p " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031480 MIMAT0000687 hsa-miR-299-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000687 "hsa-miR-299, hsa-miR-299-5p " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031481 MIMAT0000687 hsa-miR-299-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000687 "hsa-miR-299, hsa-miR-299-5p " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031482 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031483 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031484 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00031485 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031486 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031487 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031488 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031489 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00031490 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031491 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00031492 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031493 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031494 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031495 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031496 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031497 MIMAT0000688 hsa-miR-301a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000688 "hsa-miR-301, hsa-miR-301a " miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031498 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 18954897 Circulating Serum qRT-PCR Fig. 2. Median fold-change differences in differentially expressed miRNAs between patient and control serum. Data are collected from Figure 2. RLID00031499 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031500 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031501 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031502 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031503 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031504 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00031505 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031506 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00031507 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00031508 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031509 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031510 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031511 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031512 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031513 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031514 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031515 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031516 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031517 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00031518 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00031519 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00031520 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031521 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031522 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031523 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031524 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031525 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031526 MIMAT0000689 hsa-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000689 hsa-miR-99b miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00031527 MIMAT0000690 hsa-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000690 hsa-miR-296 miRNA Homo sapiens 21690488 Circulating Plasma qRT-PCR "The expressions of selected miRNAs (miR-296-5p, let-7e, and a human cytomegalovirus [HCMV]-encoded miRNA, hcmv-miR-UL112) were validated independently in plasma samples from 24 hypertensive patients and 22 control subjects. " RLID00031528 MIMAT0000690 hsa-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000690 hsa-miR-296 miRNA Homo sapiens 25405200 Circulating Serum qRT-PCR "Individual qRT-PCR results (expression level) of serum miRNA expression in macrosomia and controls is shown in Table 3, including has-miR-122, has-miR-192, has-miR-194, has-miR-296-5p, has-miR-376a, has-miR-487b, has-miR-505, has-miR-1262 " RLID00031529 MIMAT0000690 hsa-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000690 hsa-miR-296 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031530 MIMAT0000690 hsa-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000690 hsa-miR-296 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031531 MIMAT0000690 hsa-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000690 hsa-miR-296 miRNA Homo sapiens 21924071 Circulating Plasma Microarray "MiR-296-5p (Fold change 0.47, P = 0.013) and miR-133b (Fold change 0.57, P = 0.033) were consistently down-regulated in the patient plasma, whereas let-7e (Fold change 1.62, P = 0.009) and hcmv-miR-UL112 (Fold change 2.72, P = 0.004), one human cytomegalovirus encoded microRNAs, were up-regulated in the patient samples. " RLID00031532 MIMAT0000690 hsa-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000690 hsa-miR-296 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031533 MIMAT0000690 hsa-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000690 hsa-miR-296 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031534 MIMAT0000690 hsa-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000690 hsa-miR-296 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031535 MIMAT0000690 hsa-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000690 hsa-miR-296 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031536 MIMAT0000690 hsa-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000690 hsa-miR-296 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031537 MIMAT0000690 hsa-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000690 hsa-miR-296 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031538 MIMAT0000690 hsa-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000690 hsa-miR-296 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00031539 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031540 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031541 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031542 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00031543 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031544 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00031545 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031546 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031547 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031548 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031549 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031550 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031551 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031552 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031553 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031554 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031555 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031556 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031557 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00031558 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 25165030 Circulating Serum RT-PCR "Although serum microRNAs (miRNAs) play essential roles in the diagnosis of various diseases, little is known about circulating miRNAs in the aging process. Solexa sequencing demonstrated 17 markedly altered miRNAs in the aging process. Quantitative reversn-PCR analysis identified five downregulated miRNAs (miR-29b, miR-106b, miR-130b, miR-142-5p, and miR-340) and three upregulated miRNAs (miR-92a, miR-222, and miR-375) with age. " RLID00031559 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00031560 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031561 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031562 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031563 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031564 MIMAT0000691 hsa-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000691 hsa-miR-130b miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00031565 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031566 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031567 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031568 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031569 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00031570 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031571 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031572 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00031573 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031574 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031575 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00031576 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00031577 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031578 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00031579 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031580 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031581 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031582 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031583 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031584 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031585 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031586 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031587 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 24577456 Circulating Serum Next-generation sequencing The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. Table 2 has displayed the data. RLID00031588 MIMAT0000692 hsa-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000692 "hsa-miR-30e-5p, hsa-miR-30e " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031589 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031590 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031591 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031592 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031593 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031594 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031595 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00031596 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031597 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031598 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031599 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031600 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031601 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031602 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031603 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00031604 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031605 MIMAT0000693 hsa-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000693 "hsa-miR-30e-3p, hsa-miR-30e* " miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00031606 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031607 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031608 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00031609 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031610 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00031611 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00031612 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031613 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00031614 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031615 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031616 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031617 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031618 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031619 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 24865854 Circulating Plasma qRT-PCR|Next-generation sequcencing "Further exploration of their levels in the plasma of CAD patient and control cases, only circulating miR-361-5p and miR-484 were more abundant in CAD cases by RT-qPCR (Fig. 2D). Levels of circulating miR-140-5p showed no different between healthy and disease population (Fig. 2D). Moreover, levels of miR-342-3p, miR-125b-5p, miR-34a-5p, miR-103a-3p, and miR-125a-5p were even reduced significantly in patient circulation (Fig. 2D). " RLID00031620 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00031621 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031622 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031623 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031624 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031625 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031626 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031627 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031628 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031629 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031630 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031631 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00031632 MIMAT0000703 hsa-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000703 hsa-miR-361 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00031633 MIMAT0000704 mmu-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000704 mmu-miR-361 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031634 MIMAT0000704 mmu-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000704 mmu-miR-361 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031635 MIMAT0000704 mmu-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000704 mmu-miR-361 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00031636 MIMAT0000704 mmu-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000704 mmu-miR-361 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031637 MIMAT0000704 mmu-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000704 mmu-miR-361 miRNA Mus musculus 23897634 Axon Neuron ball cultures Fluorescence in situ hybridization "We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)].We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)]. Data are collected from Table 1. " RLID00031638 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031639 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031640 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031641 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031642 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031643 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031644 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031645 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031646 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031647 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00031648 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031649 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031650 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031651 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031652 MIMAT0000705 hsa-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000705 hsa-miR-362 miRNA Homo sapiens 20668554 Microvesicle MSC cell qRT-PCR Table 5: Selectively expressed miRNAs from MSC MVs and their cells of origin. Data are collected from Table 5. RLID00031653 MIMAT0000706 mmu-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000706 mmu-miR-362 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00031654 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031655 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031656 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031657 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00031658 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00031659 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031660 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031661 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00031662 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031663 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031664 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031665 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031666 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031667 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031668 MIMAT0000707 hsa-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000707 hsa-miR-363 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031669 MIMAT0000708 mmu-miR-363-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000708 mmu-miR-363 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031670 MIMAT0000710 hsa-miR-365a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000710 hsa-miR-365 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031671 MIMAT0000710 hsa-miR-365a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000710 hsa-miR-365 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031672 MIMAT0000710 hsa-miR-365a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000710 hsa-miR-365 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031673 MIMAT0000710 hsa-miR-365a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000710 hsa-miR-365 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031674 MIMAT0000710 hsa-miR-365a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000710 hsa-miR-365 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031675 MIMAT0000710 hsa-miR-365a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000710 hsa-miR-365 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031676 MIMAT0000710 hsa-miR-365a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000710 hsa-miR-365 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031677 MIMAT0000710 hsa-miR-365a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000710 hsa-miR-365 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031678 MIMAT0000710 hsa-miR-365a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000710 hsa-miR-365 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00031679 MIMAT0000710 hsa-miR-365a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000710 hsa-miR-365 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00031680 MIMAT0000710 hsa-miR-365a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000710 hsa-miR-365 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031681 MIMAT0000710 hsa-miR-365a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000710 hsa-miR-365 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031682 MIMAT0000710 hsa-miR-365a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000710 hsa-miR-365 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00031683 MIMAT0000711 mmu-miR-365-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000711 mmu-miR-365 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031684 MIMAT0000711 mmu-miR-365-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000711 mmu-miR-365 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031685 MIMAT0000711 mmu-miR-365-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000711 mmu-miR-365 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00031686 MIMAT0000714 hsa-miR-302b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000714 hsa-miR-302b* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031687 MIMAT0000715 hsa-miR-302b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000715 hsa-miR-302b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031688 MIMAT0000715 hsa-miR-302b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000715 hsa-miR-302b miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00031689 MIMAT0000715 hsa-miR-302b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000715 hsa-miR-302b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031690 MIMAT0000716 hsa-miR-302c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000716 hsa-miR-302c* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031691 MIMAT0000717 hsa-miR-302c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000717 hsa-miR-302c miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031692 MIMAT0000717 hsa-miR-302c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000717 hsa-miR-302c miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00031693 MIMAT0000717 hsa-miR-302c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000717 hsa-miR-302c miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00031694 MIMAT0000717 hsa-miR-302c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000717 hsa-miR-302c miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031695 MIMAT0000718 hsa-miR-302d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000718 hsa-miR-302d miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031696 MIMAT0000719 hsa-miR-367-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000719 hsa-miR-367 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031697 MIMAT0000719 hsa-miR-367-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000719 hsa-miR-367 miRNA Homo sapiens 22529849 Exosome HCC cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031698 MIMAT0000720 hsa-miR-376c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000720 "hsa-miR-368, hsa-miR-376c " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031699 MIMAT0000720 hsa-miR-376c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000720 "hsa-miR-368, hsa-miR-376c " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031700 MIMAT0000720 hsa-miR-376c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000720 "hsa-miR-368, hsa-miR-376c " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031701 MIMAT0000720 hsa-miR-376c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000720 "hsa-miR-368, hsa-miR-376c " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031702 MIMAT0000720 hsa-miR-376c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000720 "hsa-miR-368, hsa-miR-376c " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031703 MIMAT0000720 hsa-miR-376c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000720 "hsa-miR-368, hsa-miR-376c " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031704 MIMAT0000721 hsa-miR-369-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000721 hsa-miR-369 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031705 MIMAT0000721 hsa-miR-369-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000721 hsa-miR-369 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031706 MIMAT0000721 hsa-miR-369-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000721 hsa-miR-369 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00031707 MIMAT0000721 hsa-miR-369-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000721 hsa-miR-369 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00031708 MIMAT0000722 hsa-miR-370-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000722 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031709 MIMAT0000722 hsa-miR-370-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000722 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00031710 MIMAT0000722 hsa-miR-370-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000722 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031711 MIMAT0000722 hsa-miR-370-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000722 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031712 MIMAT0000722 hsa-miR-370-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000722 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031713 MIMAT0000722 hsa-miR-370-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000722 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031714 MIMAT0000722 hsa-miR-370-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000722 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031715 MIMAT0000722 hsa-miR-370-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000722 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031716 MIMAT0000722 hsa-miR-370-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000722 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031717 MIMAT0000723 hsa-miR-371a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000723 "hsa-miR-371, hsa-miR-371-3p " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031718 MIMAT0000723 hsa-miR-371a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000723 "hsa-miR-371, hsa-miR-371-3p " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031719 MIMAT0000724 hsa-miR-372-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000724 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031720 MIMAT0000724 hsa-miR-372-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000724 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031721 MIMAT0000725 hsa-miR-373-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000725 hsa-miR-373* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031722 MIMAT0000725 hsa-miR-373-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000725 hsa-miR-373* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031723 MIMAT0000726 hsa-miR-373-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000726 hsa-miR-373 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031724 MIMAT0000726 hsa-miR-373-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000726 hsa-miR-373 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031725 MIMAT0000726 hsa-miR-373-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000726 hsa-miR-373 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031726 MIMAT0000726 hsa-miR-373-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000726 hsa-miR-373 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00031727 MIMAT0000726 hsa-miR-373-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000726 hsa-miR-373 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00031728 MIMAT0000726 hsa-miR-373-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000726 hsa-miR-373 miRNA Homo sapiens 22529849 Exosome Liver carcinoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031729 MIMAT0000726 hsa-miR-373-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000726 hsa-miR-373 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031730 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031731 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031732 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031733 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00031734 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031735 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031736 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031737 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00031738 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00031739 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031740 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031741 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031742 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031743 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031744 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031745 MIMAT0000727 hsa-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000727 "hsa-miR-374, hsa-miR-374a " miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031746 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 21098710 Circulating Serum qRT-PCR "By selecting miRNAs that have 3-fold higher expression in HBV compared with control serum, we identified total of 13 upregulated miRNAs, including miR-375, miR-92a, miR-10a, miR-223, miR-423, miR-23b/a, miR-342-3p, miR-99a, miR-122a, miR-125b, miR-150, and let-7c. As shown in Figure 2, the upregulation of these 13 miRNA expressions in the serum of HBV cases, compared with those of controls, was largely consistent when detected by Solexa in pooled samples and qRT-PCR in individual samples. Data are collected from Figure 2. " RLID00031747 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031748 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031749 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031750 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031751 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031752 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031753 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031754 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 23461060 Circulating Serum qRT-PCR "The circulating serum levels of miR-375 in patients who had distal gastric adenocarcinoma were also much lower than normal controls (p < 0.001). As a biomarker, miR-375 yielded a receiver operating characteristic area under the curve of 0.835. " RLID00031755 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031756 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031757 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031758 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031759 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00031760 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00031761 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031762 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00031763 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00031764 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 25165030 Circulating Serum RT-PCR "Although serum microRNAs (miRNAs) play essential roles in the diagnosis of various diseases, little is known about circulating miRNAs in the aging process. Solexa sequencing demonstrated 17 markedly altered miRNAs in the aging process. Quantitative reversn-PCR analysis identified five downregulated miRNAs (miR-29b, miR-106b, miR-130b, miR-142-5p, and miR-340) and three upregulated miRNAs (miR-92a, miR-222, and miR-375) with age. " RLID00031765 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031766 MIMAT0000728 hsa-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000728 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031767 MIMAT0000729 hsa-miR-376a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000729 hsa-miR-376a miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031768 MIMAT0000729 hsa-miR-376a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000729 hsa-miR-376a miRNA Homo sapiens 25405200 Circulating Serum qRT-PCR "Individual qRT-PCR results (expression level) of serum miRNA expression in macrosomia and controls is shown in Table 3, including has-miR-122, has-miR-192, has-miR-194, has-miR-296-5p, has-miR-376a, has-miR-487b, has-miR-505, has-miR-1262 " RLID00031769 MIMAT0000729 hsa-miR-376a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000729 hsa-miR-376a miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031770 MIMAT0000729 hsa-miR-376a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000729 hsa-miR-376a miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00031771 MIMAT0000729 hsa-miR-376a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000729 hsa-miR-376a miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031772 MIMAT0000729 hsa-miR-376a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000729 hsa-miR-376a miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031773 MIMAT0000729 hsa-miR-376a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000729 hsa-miR-376a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031774 MIMAT0000729 hsa-miR-376a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000729 hsa-miR-376a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031775 MIMAT0000729 hsa-miR-376a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000729 hsa-miR-376a miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031776 MIMAT0000729 hsa-miR-376a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000729 hsa-miR-376a miRNA Homo sapiens 22529849 Exosome HCC cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031777 MIMAT0000729 hsa-miR-376a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000729 hsa-miR-376a miRNA Homo sapiens 20668554 Microvesicle MSC cell qRT-PCR Table 5: Selectively expressed miRNAs from MSC MVs and their cells of origin. Data are collected from Table 5. RLID00031778 MIMAT0000730 hsa-miR-377-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000730 hsa-miR-377 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00031779 MIMAT0000730 hsa-miR-377-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000730 hsa-miR-377 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031780 MIMAT0000730 hsa-miR-377-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000730 hsa-miR-377 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031781 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031782 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00031783 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031784 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031785 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031786 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031787 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00031788 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031789 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031790 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031791 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031792 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031793 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031794 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031795 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031796 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031797 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031798 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00031799 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031800 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 22529849 Exosome HCC cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031801 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031802 MIMAT0000731 hsa-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000731 "hsa-miR-378, hsa-miR-378* " miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00031803 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031804 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031805 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031806 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00031807 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031808 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031809 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031810 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031811 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00031812 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031813 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031814 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031815 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00031816 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031817 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031818 MIMAT0000732 hsa-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000732 "hsa-miR-422b, hsa-miR-378 " miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00031819 MIMAT0000733 hsa-miR-379-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000733 hsa-miR-379 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00031820 MIMAT0000733 hsa-miR-379-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000733 hsa-miR-379 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031821 MIMAT0000733 hsa-miR-379-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000733 hsa-miR-379 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031822 MIMAT0000733 hsa-miR-379-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000733 hsa-miR-379 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00031823 MIMAT0000733 hsa-miR-379-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000733 hsa-miR-379 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031824 MIMAT0000733 hsa-miR-379-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000733 hsa-miR-379 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031825 MIMAT0000734 hsa-miR-380-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000734 "hsa-miR-380-5p, hsa-miR-380* " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031826 MIMAT0000734 hsa-miR-380-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000734 "hsa-miR-380-5p, hsa-miR-380* " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031827 MIMAT0000735 hsa-miR-380-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000735 "hsa-miR-380-3p, hsa-miR-380 " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031828 MIMAT0000735 hsa-miR-380-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000735 "hsa-miR-380-3p, hsa-miR-380 " miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00031829 MIMAT0000735 hsa-miR-380-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000735 "hsa-miR-380-3p, hsa-miR-380 " miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00031830 MIMAT0000736 hsa-miR-381-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000736 hsa-miR-381 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00031831 MIMAT0000736 hsa-miR-381-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000736 hsa-miR-381 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031832 MIMAT0000736 hsa-miR-381-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000736 hsa-miR-381 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031833 MIMAT0000736 hsa-miR-381-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000736 hsa-miR-381 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00031834 MIMAT0000736 hsa-miR-381-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000736 hsa-miR-381 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031835 MIMAT0000736 hsa-miR-381-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000736 hsa-miR-381 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00031836 MIMAT0000737 hsa-miR-382-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000737 hsa-miR-382 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031837 MIMAT0000737 hsa-miR-382-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000737 hsa-miR-382 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00031838 MIMAT0000737 hsa-miR-382-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000737 hsa-miR-382 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031839 MIMAT0000737 hsa-miR-382-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000737 hsa-miR-382 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031840 MIMAT0000737 hsa-miR-382-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000737 hsa-miR-382 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031841 MIMAT0000737 hsa-miR-382-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000737 hsa-miR-382 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031842 MIMAT0000737 hsa-miR-382-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000737 hsa-miR-382 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00031843 MIMAT0000737 hsa-miR-382-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000737 hsa-miR-382 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031844 MIMAT0000737 hsa-miR-382-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000737 hsa-miR-382 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031845 MIMAT0000737 hsa-miR-382-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000737 hsa-miR-382 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00031846 MIMAT0000737 hsa-miR-382-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000737 hsa-miR-382 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00031847 MIMAT0000738 hsa-miR-383-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000738 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031848 MIMAT0000738 hsa-miR-383-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000738 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031849 MIMAT0000739 mmu-miR-375-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000739 mmu-miR-375 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031850 MIMAT0000741 mmu-miR-377-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000741 mmu-miR-377 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00031851 MIMAT0000742 mmu-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000742 "mmu-miR-378, mmu-miR-378*, mmu-miR-378-5p " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00031852 MIMAT0000742 mmu-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000742 "mmu-miR-378, mmu-miR-378*, mmu-miR-378-5p " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031853 MIMAT0000743 mmu-miR-379-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000743 mmu-miR-379 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031854 MIMAT0000743 mmu-miR-379-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000743 mmu-miR-379 miRNA Mus musculus 23897634 Cell body Neuron ball cultures Fluorescence in situ hybridization Data are collected from Table 2: Cell Body-Enriched miRNAs. RLID00031855 MIMAT0000744 mmu-miR-380-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000744 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031856 MIMAT0000746 mmu-miR-381-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000746 mmu-miR-381 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00031857 MIMAT0000746 mmu-miR-381-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000746 mmu-miR-381 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00031858 MIMAT0000747 mmu-miR-382-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000747 mmu-miR-382 miRNA Mus musculus 23897634 Axon Neuron ball cultures Fluorescence in situ hybridization "We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)].We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)]. Data are collected from Table 1. " RLID00031859 MIMAT0000750 hsa-miR-340-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000750 "hsa-miR-340, hsa-miR-340* " miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00031860 MIMAT0000750 hsa-miR-340-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000750 "hsa-miR-340, hsa-miR-340* " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031861 MIMAT0000750 hsa-miR-340-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000750 "hsa-miR-340, hsa-miR-340* " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031862 MIMAT0000750 hsa-miR-340-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000750 "hsa-miR-340, hsa-miR-340* " miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00031863 MIMAT0000750 hsa-miR-340-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000750 "hsa-miR-340, hsa-miR-340* " miRNA Homo sapiens 25165030 Circulating Serum RT-PCR "Although serum microRNAs (miRNAs) play essential roles in the diagnosis of various diseases, little is known about circulating miRNAs in the aging process. Solexa sequencing demonstrated 17 markedly altered miRNAs in the aging process. Quantitative reversn-PCR analysis identified five downregulated miRNAs (miR-29b, miR-106b, miR-130b, miR-142-5p, and miR-340) and three upregulated miRNAs (miR-92a, miR-222, and miR-375) with age. " RLID00031864 MIMAT0000750 hsa-miR-340-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000750 "hsa-miR-340, hsa-miR-340* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031865 MIMAT0000750 hsa-miR-340-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000750 "hsa-miR-340, hsa-miR-340* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031866 MIMAT0000750 hsa-miR-340-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000750 "hsa-miR-340, hsa-miR-340* " miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00031867 MIMAT0000751 hsa-miR-330-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000751 hsa-miR-330 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031868 MIMAT0000751 hsa-miR-330-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000751 hsa-miR-330 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031869 MIMAT0000751 hsa-miR-330-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000751 hsa-miR-330 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031870 MIMAT0000751 hsa-miR-330-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000751 hsa-miR-330 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031871 MIMAT0000751 hsa-miR-330-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000751 hsa-miR-330 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031872 MIMAT0000751 hsa-miR-330-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000751 hsa-miR-330 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031873 MIMAT0000751 hsa-miR-330-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000751 hsa-miR-330 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031874 MIMAT0000751 hsa-miR-330-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000751 hsa-miR-330 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031875 MIMAT0000751 hsa-miR-330-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000751 hsa-miR-330 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031876 MIMAT0000751 hsa-miR-330-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000751 hsa-miR-330 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031877 MIMAT0000751 hsa-miR-330-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000751 hsa-miR-330 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031878 MIMAT0000751 hsa-miR-330-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000751 hsa-miR-330 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031879 MIMAT0000751 hsa-miR-330-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000751 hsa-miR-330 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031880 MIMAT0000751 hsa-miR-330-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000751 hsa-miR-330 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031881 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00031882 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031883 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031884 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031885 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 25126405 Circulating Serum qRT-PCR "Circulating miRNAs in the serum and plasma are remarkably stable and are suggested to have promise as noninvasive biomarkers for neurological and neurodevelopmental disorders. Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated. " RLID00031886 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00031887 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031888 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031889 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031890 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031891 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00031892 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031893 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00031894 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031895 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031896 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031897 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray|RT-PCR "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00031898 MIMAT0000752 hsa-miR-328-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000752 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031899 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 21098710 Circulating Serum qRT-PCR "By selecting miRNAs that have 3-fold higher expression in HBV compared with control serum, we identified total of 13 upregulated miRNAs, including miR-375, miR-92a, miR-10a, miR-223, miR-423, miR-23b/a, miR-342-3p, miR-99a, miR-122a, miR-125b, miR-150, and let-7c. As shown in Figure 2, the upregulation of these 13 miRNA expressions in the serum of HBV cases, compared with those of controls, was largely consistent when detected by Solexa in pooled samples and qRT-PCR in individual samples. Data are collected from Figure 2. " RLID00031900 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031901 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031902 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031903 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031904 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031905 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00031906 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031907 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031908 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031909 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031910 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031911 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00031912 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031913 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031914 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031915 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031916 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031917 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR "Even under such stringent criteria, 11 miRNAs can be identified as miRNAs that are detectable in the nucleolus with very high levels of confidence (Figure 1D, Table S2). Since the detected nucleolar contents of many of these RNAs are very high, we termed these 11 miRNAs as nucleolar miRNAs. " RLID00031918 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031919 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00031920 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031921 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00031922 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00031923 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00031924 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00031925 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031926 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031927 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031928 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031929 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 24865854 Circulating Plasma qRT-PCR|Next-generation sequcencing "Further exploration of their levels in the plasma of CAD patient and control cases, only circulating miR-361-5p and miR-484 were more abundant in CAD cases by RT-qPCR (Fig. 2D). Levels of circulating miR-140-5p showed no different between healthy and disease population (Fig. 2D). Moreover, levels of miR-342-3p, miR-125b-5p, miR-34a-5p, miR-103a-3p, and miR-125a-5p were even reduced significantly in patient circulation (Fig. 2D). " RLID00031930 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 24577456 Circulating Serum Next-generation sequencing The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. Table 2 has displayed the data. RLID00031931 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00031932 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00031933 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031934 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 22529849 Exosome Liver carcinoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031935 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031936 MIMAT0000753 hsa-miR-342-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000753 hsa-miR-342 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00031937 MIMAT0000754 hsa-miR-337-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000754 hsa-miR-337 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031938 MIMAT0000754 hsa-miR-337-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000754 hsa-miR-337 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031939 MIMAT0000754 hsa-miR-337-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000754 hsa-miR-337 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031940 MIMAT0000754 hsa-miR-337-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000754 hsa-miR-337 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031941 MIMAT0000754 hsa-miR-337-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000754 hsa-miR-337 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031942 MIMAT0000755 hsa-miR-323a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000755 "hsa-miR-323, hsa-miR-323-3p " miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00031943 MIMAT0000755 hsa-miR-323a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000755 "hsa-miR-323, hsa-miR-323-3p " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031944 MIMAT0000755 hsa-miR-323a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000755 "hsa-miR-323, hsa-miR-323-3p " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031945 MIMAT0000755 hsa-miR-323a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000755 "hsa-miR-323, hsa-miR-323-3p " miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031946 MIMAT0000755 hsa-miR-323a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000755 "hsa-miR-323, hsa-miR-323-3p " miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031947 MIMAT0000755 hsa-miR-323a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000755 "hsa-miR-323, hsa-miR-323-3p " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031948 MIMAT0000755 hsa-miR-323a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000755 "hsa-miR-323, hsa-miR-323-3p " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031949 MIMAT0000755 hsa-miR-323a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000755 "hsa-miR-323, hsa-miR-323-3p " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031950 MIMAT0000755 hsa-miR-323a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000755 "hsa-miR-323, hsa-miR-323-3p " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031951 MIMAT0000755 hsa-miR-323a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000755 "hsa-miR-323, hsa-miR-323-3p " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031952 MIMAT0000755 hsa-miR-323a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000755 "hsa-miR-323, hsa-miR-323-3p " miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00031953 MIMAT0000755 hsa-miR-323a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000755 "hsa-miR-323, hsa-miR-323-3p " miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00031954 MIMAT0000755 hsa-miR-323a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000755 "hsa-miR-323, hsa-miR-323-3p " miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00031955 MIMAT0000756 hsa-miR-326 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000756 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031956 MIMAT0000756 hsa-miR-326 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000756 miRNA Homo sapiens 24937531 Circulating Plasma qRT-PCR "Quantitative RT-PCR validation confirmed the significant up-regulation of miR-326 (P = .004) and down-regulation of let-7a (P < .001) and let-7f (P = .003). Notably, an inverse negative correlation was found between circulating miR-326 and its putative target adiponectin (p = -0.479, P = .009). " RLID00031957 MIMAT0000756 hsa-miR-326 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000756 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031958 MIMAT0000756 hsa-miR-326 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000756 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031959 MIMAT0000756 hsa-miR-326 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000756 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031960 MIMAT0000756 hsa-miR-326 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000756 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031961 MIMAT0000756 hsa-miR-326 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000756 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031962 MIMAT0000756 hsa-miR-326 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000756 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031963 MIMAT0000756 hsa-miR-326 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000756 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00031964 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031965 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00031966 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00031967 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031968 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 25126405 Circulating Serum qRT-PCR "Circulating miRNAs in the serum and plasma are remarkably stable and are suggested to have promise as noninvasive biomarkers for neurological and neurodevelopmental disorders. Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated. " RLID00031969 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031970 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00031971 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031972 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00031973 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00031974 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00031975 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031976 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031977 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00031978 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00031979 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00031980 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00031981 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031982 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00031983 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031984 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00031985 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00031986 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031987 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00031988 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031989 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031990 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00031991 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031992 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00031993 MIMAT0000757 hsa-miR-151a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000757 "hsa-miR-151, hsa-miR-151-3p " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00031994 MIMAT0000758 hsa-miR-135b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000758 hsa-miR-135b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00031995 MIMAT0000758 hsa-miR-135b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000758 hsa-miR-135b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00031996 MIMAT0000758 hsa-miR-135b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000758 hsa-miR-135b miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00031997 MIMAT0000758 hsa-miR-135b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000758 hsa-miR-135b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00031998 MIMAT0000758 hsa-miR-135b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000758 hsa-miR-135b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00031999 MIMAT0000758 hsa-miR-135b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000758 hsa-miR-135b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032000 MIMAT0000758 hsa-miR-135b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000758 hsa-miR-135b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032001 MIMAT0000758 hsa-miR-135b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000758 hsa-miR-135b miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032002 MIMAT0000758 hsa-miR-135b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000758 hsa-miR-135b miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032003 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032004 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032005 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00032006 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032007 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00032008 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032009 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032010 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032011 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032012 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 19951903 Microvesicle Plasma qRT-PCR|Microarray "We found several miRNAs whose expression was consistently up-regulated in blood microvesicles samples from IBS patients with increased membrane permeability compared to controls (Figure 2A-lower, left panel). Three up-regulated miRNAs with a p<0.001 were identified: miR-142-3p, miRNA-29a and miR-148b (Figure 2A-lower, left panel). " RLID00032013 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00032014 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00032015 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032016 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032017 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032018 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032019 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032020 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032021 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032022 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00032023 MIMAT0000759 hsa-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000759 hsa-miR-148b miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032024 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032025 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032026 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032027 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032028 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032029 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032030 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00032031 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032032 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032033 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032034 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00032035 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032036 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032037 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032038 MIMAT0000760 hsa-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000760 hsa-miR-331 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032039 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032040 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032041 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00032042 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032043 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032044 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032045 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032046 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032047 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032048 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032049 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032050 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032051 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00032052 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032053 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032054 MIMAT0000761 hsa-miR-324-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000761 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032055 MIMAT0000762 hsa-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000762 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032056 MIMAT0000762 hsa-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000762 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032057 MIMAT0000762 hsa-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000762 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032058 MIMAT0000762 hsa-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000762 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032059 MIMAT0000762 hsa-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000762 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032060 MIMAT0000762 hsa-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000762 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032061 MIMAT0000762 hsa-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000762 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032062 MIMAT0000762 hsa-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000762 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032063 MIMAT0000762 hsa-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000762 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00032064 MIMAT0000762 hsa-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000762 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032065 MIMAT0000762 hsa-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000762 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032066 MIMAT0000762 hsa-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000762 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032067 MIMAT0000762 hsa-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000762 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032068 MIMAT0000762 hsa-miR-324-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000762 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032069 MIMAT0000763 hsa-miR-338-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000763 hsa-miR-338 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032070 MIMAT0000763 hsa-miR-338-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000763 hsa-miR-338 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032071 MIMAT0000763 hsa-miR-338-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000763 hsa-miR-338 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032072 MIMAT0000763 hsa-miR-338-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000763 hsa-miR-338 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032073 MIMAT0000763 hsa-miR-338-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000763 hsa-miR-338 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032074 MIMAT0000763 hsa-miR-338-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000763 hsa-miR-338 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032075 MIMAT0000763 hsa-miR-338-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000763 hsa-miR-338 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032076 MIMAT0000763 hsa-miR-338-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000763 hsa-miR-338 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032077 MIMAT0000763 hsa-miR-338-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000763 hsa-miR-338 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00032078 MIMAT0000763 hsa-miR-338-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000763 hsa-miR-338 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032079 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032080 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00032081 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032082 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00032083 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032084 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032085 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032086 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00032087 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032088 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032089 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032090 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032091 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032092 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032093 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032094 MIMAT0000764 hsa-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000764 hsa-miR-339 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032095 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032096 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032097 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00032098 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032099 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 21505438 Exosome Primary dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032100 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00032101 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032102 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032103 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032104 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00032105 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032106 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00032107 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032108 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032109 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032110 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 22529849 Exosome T cell|B cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032111 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032112 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032113 MIMAT0000765 hsa-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000765 hsa-miR-335 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00032114 MIMAT0000766 mmu-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000766 mmu-miR-335 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00032115 MIMAT0000766 mmu-miR-335-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000766 mmu-miR-335 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00032116 MIMAT0000770 hsa-miR-133b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000770 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00032117 MIMAT0000770 hsa-miR-133b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000770 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032118 MIMAT0000770 hsa-miR-133b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000770 miRNA Homo sapiens 21924071 Circulating Plasma Microarray "MiR-296-5p (Fold change 0.47, P = 0.013) and miR-133b (Fold change 0.57, P = 0.033) were consistently down-regulated in the patient plasma, whereas let-7e (Fold change 1.62, P = 0.009) and hcmv-miR-UL112 (Fold change 2.72, P = 0.004), one human cytomegalovirus encoded microRNAs, were up-regulated in the patient samples. " RLID00032119 MIMAT0000770 hsa-miR-133b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000770 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032120 MIMAT0000770 hsa-miR-133b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000770 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00032121 MIMAT0000770 hsa-miR-133b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000770 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032122 MIMAT0000770 hsa-miR-133b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000770 miRNA Homo sapiens 22529849 Exosome HCC cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032123 MIMAT0000770 hsa-miR-133b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000770 miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032124 MIMAT0000771 hsa-miR-325 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000771 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032125 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032126 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032127 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032128 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032129 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032130 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032131 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032132 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032133 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00032134 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00032135 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032136 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032137 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00032138 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032139 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032140 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032141 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032142 MIMAT0000772 hsa-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000772 hsa-miR-345 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032143 MIMAT0000773 hsa-miR-346 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000773 miRNA Homo sapiens 22094284 Circulating serum qRT-PCR|RNA-seq "When compared with family schizophrenia patients, circulating miR-219-2-3p, miR-92a, miR-346, let-7g and miR-17 were significantly higher in sporadic schizophrenia ( p < 0.001, Fig. 4 ). On contrary, miR-181b and miR-195 were significantlydown-regulated in sporadic schizophrenia compared with family schizophrenia patients ( p < 0.001), miR-1308 was slightly lower in sporadic schizophrenia compared family schizophrenia patients (0.05 < p < 0.001), and miR-103 was highly consistent between sporadic schizophrenia and family schizophrenia patients ( p > 0.05). These data indicate that there is a close relationship between levels of circulating miRNAs and schizophrenia patients whether they have the family history or not. " RLID00032144 MIMAT0000773 hsa-miR-346 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000773 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032145 MIMAT0000773 hsa-miR-346 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000773 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032146 MIMAT0000773 hsa-miR-346 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000773 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032147 MIMAT0000773 hsa-miR-346 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000773 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032148 MIMAT0000773 hsa-miR-346 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000773 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032149 MIMAT0000773 hsa-miR-346 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000773 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032150 MIMAT0000774 rno-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000774 rno-let-7a miRNA Rattus norvegicus 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00032151 MIMAT0000774 rno-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000774 rno-let-7a miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032152 MIMAT0000775 rno-let-7b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000775 rno-let-7b miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032153 MIMAT0000776 rno-let-7c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000776 rno-let-7c miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032154 MIMAT0000777 rno-let-7e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000777 rno-let-7e miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032155 MIMAT0000781 rno-miR-9a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000781 rno-miR-9 miRNA Rattus norvegicus 19465924 Synapse Hippocampus In situ hybridization|Northern blot "The observed enrichment of several miRNAs in RNA preparations from synaptosomes was validated for selected candidates by Northern blot analysis (Fig. 2A). To monitor the subcellular localization of miRNAs identified in our screen, we performed in situ hybridization (ISH) in rat hippocampal neurons at 18 days in vitro (DIV) (Fig. 2B), using probes for miR-9, miR-218, miR-138 and miR-124 as a control (Fig. 2A, Suppl. Table 1). Data are collected from Figure 2. " RLID00032156 MIMAT0000783 rno-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000783 rno-miR-10b miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032157 MIMAT0000784 rno-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000784 rno-miR-15b miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032158 MIMAT0000784 rno-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000784 rno-miR-15b miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "However, a number of miRNAs were observed that were significantly enriched in the axons compared with the cell bodies, while others were enriched or present only in the cell bodies. For example, miR-204, miR-221, miR-15b, and miR-16 are characterized by the former pattern, while miR-297, miR-206, and miR-124a are examples of the latter pattern. " RLID00032159 MIMAT0000784 rno-miR-15b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000784 rno-miR-15b miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032160 MIMAT0000785 rno-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000785 rno-miR-16 miRNA Rattus norvegicus 21435393 Microvesicle Serum RT-PCR "By using RT-PCR and specific forward/reverse primers these microRNAs were all detected in microvesicles, that had been released from primary and differentiated rat adipocytes after 6 and 24h incubation, respectively, as well as in microvesicles from rat serum(Fig. 6; shown only for miR-16, miR-27a, miR-146b and miR-222). " RLID00032161 MIMAT0000785 rno-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000785 rno-miR-16 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "However, a number of miRNAs were observed that were significantly enriched in the axons compared with the cell bodies, while others were enriched or present only in the cell bodies. For example, miR-204, miR-221, miR-15b, and miR-16 are characterized by the former pattern, while miR-297, miR-206, and miR-124a are examples of the latter pattern. " RLID00032162 MIMAT0000785 rno-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000785 rno-miR-16 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032163 MIMAT0000785 rno-miR-16-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000785 rno-miR-16 miRNA Rattus norvegicus 22529849 Exosome Adipocytes - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032164 MIMAT0000787 rno-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000787 "rno-miR-18, rno-miR-18a " miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032165 MIMAT0000787 rno-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000787 "rno-miR-18, rno-miR-18a " miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032166 MIMAT0000787 rno-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000787 "rno-miR-18, rno-miR-18a " miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032167 MIMAT0000787 rno-miR-18a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000787 "rno-miR-18, rno-miR-18a " miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032168 MIMAT0000788 rno-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000788 rno-miR-19b miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032169 MIMAT0000788 rno-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000788 rno-miR-19b miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032170 MIMAT0000788 rno-miR-19b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000788 rno-miR-19b miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032171 MIMAT0000789 rno-miR-19a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000789 rno-miR-19a miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032172 MIMAT0000790 rno-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000790 rno-miR-21 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032173 MIMAT0000790 rno-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000790 rno-miR-21 miRNA Rattus norvegicus 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00032174 MIMAT0000790 rno-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000790 rno-miR-21 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032175 MIMAT0000790 rno-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000790 rno-miR-21 miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032176 MIMAT0000790 rno-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000790 rno-miR-21 miRNA Rattus norvegicus 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00032177 MIMAT0000790 rno-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000790 rno-miR-21 miRNA Rattus norvegicus 23978520 Microvesicle NRK-52E cell qRT-PCR|In situ hybridization "These results demonstrate that tubular cells can secrete miR-21 and deliver it into recipient tubules by microvesicles, where the exogenous miR-21 can target PTEN protein and enhance Akt signaling in recipient cells. " RLID00032178 MIMAT0000790 rno-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000790 rno-miR-21 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032179 MIMAT0000791 rno-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000791 rno-miR-22 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032180 MIMAT0000791 rno-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000791 rno-miR-22 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032181 MIMAT0000791 rno-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000791 rno-miR-22 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032182 MIMAT0000791 rno-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000791 rno-miR-22 miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032183 MIMAT0000791 rno-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000791 rno-miR-22 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032184 MIMAT0000792 rno-miR-23a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000792 rno-miR-23a miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032185 MIMAT0000793 rno-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000793 rno-miR-23b miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032186 MIMAT0000793 rno-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000793 rno-miR-23b miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032187 MIMAT0000793 rno-miR-23b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000793 rno-miR-23b miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032188 MIMAT0000794 rno-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000794 rno-miR-24 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032189 MIMAT0000794 rno-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000794 rno-miR-24 miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032190 MIMAT0000794 rno-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000794 rno-miR-24 miRNA Rattus norvegicus 24324399 Nucleus Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032191 MIMAT0000794 rno-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000794 rno-miR-24 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032192 MIMAT0000795 rno-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000795 rno-miR-25 miRNA Rattus norvegicus 24324399 Nucleus Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032193 MIMAT0000795 rno-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000795 rno-miR-25 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032194 MIMAT0000795 rno-miR-25-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000795 rno-miR-25 miRNA Rattus norvegicus 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00032195 MIMAT0000796 rno-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000796 rno-miR-26a miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032196 MIMAT0000796 rno-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000796 rno-miR-26a miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032197 MIMAT0000796 rno-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000796 rno-miR-26a miRNA Rattus norvegicus 17592044 Dendrite Hippocampus In situ hybridization|RT-PCR "Dendritic miRNAs appeared punctate by in situ hybridization (Fig. 4), a pattern typical of many dendritic mRNA populations. Fogure 4: miRNAs appear granular by in situ hybridization in cultured hippocampal neurons. (A) rno-miR-26a. (B) High power of rno-miR-26a puncta; (C) rno-miR-92; (D) rno-let-7d; and (E) rno-124a. Images were acquired using a confocal microscope. (A,C,D,E) Scale bar, 50 um; (B) scale bar, 5 um. " RLID00032198 MIMAT0000796 rno-miR-26a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000796 rno-miR-26a miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032199 MIMAT0000797 rno-miR-26b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000797 rno-miR-26b miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032200 MIMAT0000798 rno-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000798 rno-miR-27b miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032201 MIMAT0000799 rno-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000799 rno-miR-27a miRNA Rattus norvegicus 21435393 Microvesicle Serum RT-PCR "By using RT-PCR and specific forward/reverse primers these microRNAs were all detected in microvesicles, that had been released from primary and differentiated rat adipocytes after 6 and 24h incubation, respectively, as well as in microvesicles from rat serum(Fig. 6; shown only for miR-16, miR-27a, miR-146b and miR-222). " RLID00032202 MIMAT0000799 rno-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000799 rno-miR-27a miRNA Rattus norvegicus 24324399 Nucleus Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032203 MIMAT0000799 rno-miR-27a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000799 rno-miR-27a miRNA Rattus norvegicus 22529849 Exosome Adipocytes - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032204 MIMAT0000801 rno-miR-29b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000801 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032205 MIMAT0000802 rno-miR-29a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000802 rno-miR-29a miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032206 MIMAT0000804 rno-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000804 rno-miR-30c miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032207 MIMAT0000804 rno-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000804 rno-miR-30c miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032208 MIMAT0000804 rno-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000804 rno-miR-30c miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032209 MIMAT0000804 rno-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000804 rno-miR-30c miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032210 MIMAT0000805 rno-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000805 rno-miR-30e miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032211 MIMAT0000805 rno-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000805 rno-miR-30e miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032212 MIMAT0000805 rno-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000805 rno-miR-30e miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032213 MIMAT0000805 rno-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000805 rno-miR-30e miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032214 MIMAT0000806 rno-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000806 rno-miR-30b miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032215 MIMAT0000806 rno-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000806 rno-miR-30b miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032216 MIMAT0000807 rno-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000807 rno-miR-30d miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032217 MIMAT0000807 rno-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000807 rno-miR-30d miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032218 MIMAT0000807 rno-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000807 rno-miR-30d miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032219 MIMAT0000807 rno-miR-30d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000807 rno-miR-30d miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032220 MIMAT0000808 rno-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000808 "rno-miR-30a-5p, rno-miR-30a " miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032221 MIMAT0000808 rno-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000808 "rno-miR-30a-5p, rno-miR-30a " miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032222 MIMAT0000810 rno-miR-31a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000810 rno-miR-31 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032223 MIMAT0000810 rno-miR-31a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000810 rno-miR-31 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032224 MIMAT0000813 rno-miR-34b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000813 rno-miR-34b miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032225 MIMAT0000813 rno-miR-34b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000813 rno-miR-34b miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032226 MIMAT0000813 rno-miR-34b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000813 rno-miR-34b miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032227 MIMAT0000814 rno-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000814 rno-miR-34c miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032228 MIMAT0000814 rno-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000814 rno-miR-34c miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032229 MIMAT0000814 rno-miR-34c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000814 rno-miR-34c miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032230 MIMAT0000815 rno-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000815 rno-miR-34a miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032231 MIMAT0000815 rno-miR-34a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000815 rno-miR-34a miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032232 MIMAT0000816 rno-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000816 "rno-miR-92, rno-miR-92a " miRNA Rattus norvegicus 24324399 Nucleus Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032233 MIMAT0000816 rno-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000816 "rno-miR-92, rno-miR-92a " miRNA Rattus norvegicus 17592044 Dendrite Hippocampus In situ hybridization|RT-PCR "Dendritic miRNAs appeared punctate by in situ hybridization (Fig. 4), a pattern typical of many dendritic mRNA populations. Fogure 4: miRNAs appear granular by in situ hybridization in cultured hippocampal neurons. (A) rno-miR-26a. (B) High power of rno-miR-26a puncta; (C) rno-miR-92; (D) rno-let-7d; and (E) rno-124a. Images were acquired using a confocal microscope. (A,C,D,E) Scale bar, 50 um; (B) scale bar, 5 um. " RLID00032234 MIMAT0000817 rno-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000817 rno-miR-93 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032235 MIMAT0000817 rno-miR-93-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000817 rno-miR-93 miRNA Rattus norvegicus 24324399 Nucleus Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032236 MIMAT0000819 rno-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000819 rno-miR-98 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032237 MIMAT0000819 rno-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000819 rno-miR-98 miRNA Rattus norvegicus 24553149 Circulating Plasma qRT-PCR|Microarray "Microarray assay results showed a total of 36 differentially-expressed miRNAs, among which 15 miRNAs were considered as aberrantly expressed with a more than 2-fold change when calculating the ratio of fluorescence intense between the 2 groups. The elevated miRNAs included miR-290, miR-874, miR-292-5p, miR-327, miR-374, miR-98, miR-352, miR-132, miR-146b, and miR-196a. The down-regulated miRNAs included miR-145, miR-329, miR-375, miR-140*, and miR-29a. Validation of microarray assay by qRT-PCR showed similar results and the ΔΔCt value compared to the sham group are shown in Figure 1. " RLID00032238 MIMAT0000819 rno-miR-98-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000819 rno-miR-98 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032239 MIMAT0000820 rno-miR-99a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000820 rno-miR-99a miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032240 MIMAT0000821 rno-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000821 rno-miR-99b miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032241 MIMAT0000821 rno-miR-99b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000821 rno-miR-99b miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032242 MIMAT0000822 rno-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000822 rno-miR-100 miRNA Rattus norvegicus 25297646 Circulating Plasma qRT-PCR|Microarray "In plasma, miRNA upregulation was observed for miR-133a and miR-133b following PH and SL, whereas miR-100 and miR-466c were similarly downregulated following anesthesia and surgery. " RLID00032243 MIMAT0000822 rno-miR-100-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000822 rno-miR-100 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032244 MIMAT0000823 rno-miR-101a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000823 "rno-miR-101, rno-miR-101a " miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032245 MIMAT0000823 rno-miR-101a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000823 "rno-miR-101, rno-miR-101a " miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032246 MIMAT0000823 rno-miR-101a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000823 "rno-miR-101, rno-miR-101a " miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032247 MIMAT0000824 rno-miR-103-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000824 rno-miR-103 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032248 MIMAT0000824 rno-miR-103-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000824 rno-miR-103 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032249 MIMAT0000825 rno-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000825 rno-miR-106b miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032250 MIMAT0000825 rno-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000825 rno-miR-106b miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032251 MIMAT0000825 rno-miR-106b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000825 rno-miR-106b miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032252 MIMAT0000826 rno-miR-107-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000826 rno-miR-107 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032253 MIMAT0000826 rno-miR-107-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000826 rno-miR-107 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032254 MIMAT0000827 rno-miR-122-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000827 "rno-miR-122a, rno-miR-122 " miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032255 MIMAT0000828 rno-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000828 "rno-miR-124a, rno-miR-124 " miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032256 MIMAT0000828 rno-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000828 "rno-miR-124a, rno-miR-124 " miRNA Rattus norvegicus 17592044 Dendrite Hippocampus In situ hybridization|RT-PCR "Dendritic miRNAs appeared punctate by in situ hybridization (Fig. 4), a pattern typical of many dendritic mRNA populations. Fogure 4: miRNAs appear granular by in situ hybridization in cultured hippocampal neurons. (A) rno-miR-26a. (B) High power of rno-miR-26a puncta; (C) rno-miR-92; (D) rno-let-7d; and (E) rno-124a. Images were acquired using a confocal microscope. (A,C,D,E) Scale bar, 50 um; (B) scale bar, 5 um. " RLID00032257 MIMAT0000828 rno-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000828 "rno-miR-124a, rno-miR-124 " miRNA Rattus norvegicus 19465924 Synapse Hippocampus In situ hybridization|Northern blot "The observed enrichment of several miRNAs in RNA preparations from synaptosomes was validated for selected candidates by Northern blot analysis (Fig. 2A). To monitor the subcellular localization of miRNAs identified in our screen, we performed in situ hybridization (ISH) in rat hippocampal neurons at 18 days in vitro (DIV) (Fig. 2B), using probes for miR-9, miR-218, miR-138 and miR-124 as a control (Fig. 2A, Suppl. Table 1). Data are collected from Figure 2. " RLID00032258 MIMAT0000828 rno-miR-124-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000828 "rno-miR-124a, rno-miR-124 " miRNA Rattus norvegicus 20584895 Cell body Sympathetic neurons Microarray "However, a number of miRNAs were observed that were significantly enriched in the axons compared with the cell bodies, while others were enriched or present only in the cell bodies. For example, miR-204, miR-221, miR-15b, and miR-16 are characterized by the former pattern, while miR-297, miR-206, and miR-124a are examples of the latter pattern. " RLID00032259 MIMAT0000829 rno-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000829 rno-miR-125a miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast In situ hybridization "MiR-199a-3p and miR-125a-5p appeared more concentrated in the nucleoplasm and cytoplasm compared with the nucleolus; their hybridization pattern more closely resembled that of let-7a, a microRNA that earlier in situ hybridization experiments had shown not to be concentrated in the nucleolus (Fig. 3; Politz et al. 2006). " RLID00032260 MIMAT0000829 rno-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000829 rno-miR-125a miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast In situ hybridization "MiR-199a-3p and miR-125a-5p appeared more concentrated in the nucleoplasm and cytoplasm compared with the nucleolus; their hybridization pattern more closely resembled that of let-7a, a microRNA that earlier in situ hybridization experiments had shown not to be concentrated in the nucleolus (Fig. 3; Politz et al. 2006). " RLID00032261 MIMAT0000829 rno-miR-125a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000829 rno-miR-125a miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032262 MIMAT0000830 rno-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000830 rno-miR-125b miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032263 MIMAT0000830 rno-miR-125b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000830 rno-miR-125b miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032264 MIMAT0000833 rno-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000833 rno-miR-127 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032265 MIMAT0000833 rno-miR-127-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000833 rno-miR-127 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032266 MIMAT0000834 rno-miR-128-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000834 "rno-miR-128a, rno-miR-128 " miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032267 MIMAT0000836 rno-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000836 rno-miR-130a miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032268 MIMAT0000836 rno-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000836 rno-miR-130a miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032269 MIMAT0000836 rno-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000836 rno-miR-130a miRNA Rattus norvegicus 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00032270 MIMAT0000836 rno-miR-130a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000836 rno-miR-130a miRNA Rattus norvegicus 19106625 Mitochondrion livers qRT-PCR|Microarray "To further define whether the miRNAs were present within the mitochondria, we used deoxycholic acid (DCA) to induce opening of the mitochondrial megapore channel33 and induction of the mitochondria permeability transition (MPT) in the isolated mitochondria.This disruption of mitochondrial integrity resulted in a significant loss of miRNAs by RT-PCR in the DCA treated mitochondria relative to the control vehicle group. The release of miR-130a and b, miR-320 and miR-494 was about 50% and that of miR-140 almost 80%. " RLID00032271 MIMAT0000837 rno-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000837 rno-miR-130b miRNA Rattus norvegicus 24324399 Nucleus Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032272 MIMAT0000837 rno-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000837 rno-miR-130b miRNA Rattus norvegicus 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00032273 MIMAT0000837 rno-miR-130b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000837 rno-miR-130b miRNA Rattus norvegicus 19106625 Mitochondrion livers qRT-PCR|Microarray "To further define whether the miRNAs were present within the mitochondria, we used deoxycholic acid (DCA) to induce opening of the mitochondrial megapore channel33 and induction of the mitochondria permeability transition (MPT) in the isolated mitochondria.This disruption of mitochondrial integrity resulted in a significant loss of miRNAs by RT-PCR in the DCA treated mitochondria relative to the control vehicle group. The release of miR-130a and b, miR-320 and miR-494 was about 50% and that of miR-140 almost 80%. " RLID00032274 MIMAT0000838 rno-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000838 rno-miR-132 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032275 MIMAT0000838 rno-miR-132-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000838 rno-miR-132 miRNA Rattus norvegicus 24553149 Circulating Plasma qRT-PCR|Microarray "Microarray assay results showed a total of 36 differentially-expressed miRNAs, among which 15 miRNAs were considered as aberrantly expressed with a more than 2-fold change when calculating the ratio of fluorescence intense between the 2 groups. The elevated miRNAs included miR-290, miR-874, miR-292-5p, miR-327, miR-374, miR-98, miR-352, miR-132, miR-146b, and miR-196a. The down-regulated miRNAs included miR-145, miR-329, miR-375, miR-140*, and miR-29a. Validation of microarray assay by qRT-PCR showed similar results and the ΔΔCt value compared to the sham group are shown in Figure 1. " RLID00032276 MIMAT0000839 rno-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000839 rno-miR-133a miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032277 MIMAT0000839 rno-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000839 rno-miR-133a miRNA Rattus norvegicus 25092230 Circulating Plasma Microarray "From the above results, miRNAs were selected as candidate plasma miRNA biomarkers as follows: miR-208 (rno-miR- 208a-3p) for cardiotoxicity; miR-1 (rno-miR-1-3p), miR-133a (rno-miR-133a-3p), miR-133a* (rno-miR-133a-5p), and miR-133b (rno-miR-133b-3p) for shared cardiotoxicity and skeletal muscle toxicity; and miR- 206 (rno-miR-206-3p) for skeletal muscle toxicity. " RLID00032278 MIMAT0000839 rno-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000839 rno-miR-133a miRNA Rattus norvegicus 25297646 Circulating Plasma qRT-PCR|Microarray "In plasma, miRNA upregulation was observed for miR-133a and miR-133b following PH and SL, whereas miR-100 and miR-466c were similarly downregulated following anesthesia and surgery. " RLID00032279 MIMAT0000839 rno-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000839 rno-miR-133a miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032280 MIMAT0000840 rno-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000840 rno-miR-134 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032281 MIMAT0000840 rno-miR-134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000840 rno-miR-134 miRNA Rattus norvegicus 16421561 Dendrite Hippocampus In situ hybridization "Here we show that a brain-specific microRNA, miR-134, is localized to the synaptodendritic compartment of rat hippocampal neurons and negatively regulates the size of dendritic spines �postsynapticsites of excitatory synaptic transmission. A substantial fraction of the dendritic miR-134 was found to partially colocalize with synapsin immunostaining, indicating that miR-134 is present near synaptic sites on dendrites (Fig. 1d, lower panel and inset at higher magnification). " RLID00032282 MIMAT0000844 rno-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000844 rno-miR-138 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032283 MIMAT0000844 rno-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000844 rno-miR-138 miRNA Rattus norvegicus 19465924 Dendrite Hippocampus In situ hybridization|Northern blot "One of the identified miRNAs, miR-138, is highly enriched in the brain, localized within dendrites and negatively regulates the size of dendritic spines in rat hippocampal neurons. The observed enrichment of several miRNAs in RNA preparations from synaptosomes was validated for selected candidates by Northern blot analysis (Fig. 2A). To monitor the subcellular localization of miRNAs identified in our screen, we performed in situ hybridization (ISH) in rat hippocampal neurons at 18 days in vitro (DIV) (Fig. 2B), using probes for miR-9, miR-218, miR-138 and miR-124 as a control (Fig. 2A, Suppl. Table 1). " RLID00032284 MIMAT0000844 rno-miR-138-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000844 rno-miR-138 miRNA Rattus norvegicus 25919946 Dendrite DRG neurons PCR MiRNAs-150 and -138 have been shown to be localize to dendrites. RLID00032285 MIMAT0000849 rno-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000849 rno-miR-143 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032286 MIMAT0000849 rno-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000849 rno-miR-143 miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032287 MIMAT0000851 rno-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000851 rno-miR-145 miRNA Rattus norvegicus 24553149 Circulating Plasma qRT-PCR|Microarray "Microarray assay results showed a total of 36 differentially-expressed miRNAs, among which 15 miRNAs were considered as aberrantly expressed with a more than 2-fold change when calculating the ratio of fluorescence intense between the 2 groups. The elevated miRNAs included miR-290, miR-874, miR-292-5p, miR-327, miR-374, miR-98, miR-352, miR-132, miR-146b, and miR-196a. The down-regulated miRNAs included miR-145, miR-329, miR-375, miR-140*, and miR-29a. Validation of microarray assay by qRT-PCR showed similar results and the ΔΔCt value compared to the sham group are shown in Figure 1. " RLID00032288 MIMAT0000852 rno-miR-146a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000852 "rno-miR-146, rno-miR-146a " miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032289 MIMAT0000853 rno-miR-150-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000853 rno-miR-150 miRNA Rattus norvegicus 25919946 Dendrite DRG neurons PCR MiRNAs-150 and -138 have been shown to be localize to dendrites. RLID00032290 MIMAT0000854 rno-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000854 rno-miR-152 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032291 MIMAT0000854 rno-miR-152-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000854 rno-miR-152 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032292 MIMAT0000856 rno-miR-154-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000856 rno-miR-154 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032293 MIMAT0000857 rno-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000857 rno-miR-181c miRNA Rattus norvegicus 22518031 Mitochondrion Heart qRT-PCR|Microarray "We find that miR-181c is encoded in the nucleus, assembled in the cytoplasm, and finally translocated into the mitochondria of cardiac myocytes. " RLID00032294 MIMAT0000857 rno-miR-181c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000857 rno-miR-181c miRNA Rattus norvegicus 22518031 Mitochondrion Heart qRT-PCR "We validated our microarray data using qPCR. 12S rRNA, a mitochondrial gene product 1, served as our internal control. We confirmed that miR-181c was predominantly localized to the mitochondrial fraction; its expression in the mitochondrial fraction was similar to that in the total heart fraction (Fig. 2A). In addition, fluorescence in situ hybridization (FISH) (Fig. 2C) shows co-localization of miR-181c with the mitochondrial marker, mitoTracker red. We also examined miR-181c expression in both cytosolic and mitochondrial fractions (Fig. 2B, left panel), using qPCR and found that miR-181c was enriched primarily in the mitochondrial fraction. We evaluated several other miRNAs as negative controls for mitochondrial localization, and miR-1192 data are included in Fig. 2B (right panel). We used 5S rRNA as an internal control for these sets of qPCR data, as it is known that this gene is present in both the cytosol and mitochondrial fractions 18. Data are collected from Figure 2. " RLID00032295 MIMAT0000858 rno-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000858 rno-miR-181a miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032296 MIMAT0000858 rno-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000858 rno-miR-181a miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032297 MIMAT0000859 rno-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000859 rno-miR-181b miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032298 MIMAT0000859 rno-miR-181b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000859 rno-miR-181b miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032299 MIMAT0000860 rno-miR-183-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000860 rno-miR-183 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032300 MIMAT0000861 rno-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000861 miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032301 MIMAT0000862 rno-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000862 rno-miR-185 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032302 MIMAT0000862 rno-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000862 rno-miR-185 miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032303 MIMAT0000862 rno-miR-185-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000862 rno-miR-185 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032304 MIMAT0000863 rno-miR-186-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000863 rno-miR-186 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032305 MIMAT0000865 rno-miR-190a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000865 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032306 MIMAT0000865 rno-miR-190a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000865 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032307 MIMAT0000866 rno-miR-191a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000866 rno-miR-191 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032308 MIMAT0000866 rno-miR-191a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000866 rno-miR-191 miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032309 MIMAT0000866 rno-miR-191a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000866 rno-miR-191 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032310 MIMAT0000867 rno-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000867 rno-miR-192 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032311 MIMAT0000867 rno-miR-192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000867 rno-miR-192 miRNA Rattus norvegicus 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00032312 MIMAT0000868 rno-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000868 rno-miR-193-3p miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032313 MIMAT0000868 rno-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000868 rno-miR-193-3p miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032314 MIMAT0000871 rno-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000871 rno-miR-196a miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032315 MIMAT0000871 rno-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000871 rno-miR-196a miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032316 MIMAT0000871 rno-miR-196a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000871 rno-miR-196a miRNA Rattus norvegicus 24553149 Circulating Plasma qRT-PCR|Microarray "Microarray assay results showed a total of 36 differentially-expressed miRNAs, among which 15 miRNAs were considered as aberrantly expressed with a more than 2-fold change when calculating the ratio of fluorescence intense between the 2 groups. The elevated miRNAs included miR-290, miR-874, miR-292-5p, miR-327, miR-374, miR-98, miR-352, miR-132, miR-146b, and miR-196a. The down-regulated miRNAs included miR-145, miR-329, miR-375, miR-140*, and miR-29a. Validation of microarray assay by qRT-PCR showed similar results and the ΔΔCt value compared to the sham group are shown in Figure 1. " RLID00032317 MIMAT0000872 rno-miR-199a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000872 rno-miR-199a miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032318 MIMAT0000876 rno-miR-203a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000876 rno-miR-203 miRNA Rattus norvegicus 23682678 Circulating Serum qRT-PCR|Microarray "Generally,there were 25 up-regulated and seven down-regulated miRNAs between serum of ASH and control groups as well as 20 up-regulated and 14 down-regulated miRNAs between liver tissues of ASH and control groups (Table 2). Data are collected from Table 2. " RLID00032319 MIMAT0000877 rno-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000877 rno-miR-204 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "However, a number of miRNAs were observed that were significantly enriched in the axons compared with the cell bodies, while others were enriched or present only in the cell bodies. For example, miR-204, miR-221, miR-15b, and miR-16 are characterized by the former pattern, while miR-297, miR-206, and miR-124a are examples of the latter pattern. " RLID00032320 MIMAT0000877 rno-miR-204-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000877 rno-miR-204 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032321 MIMAT0000879 rno-miR-206-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000879 rno-miR-206 miRNA Rattus norvegicus 17135348 Cytoplasm Myogenic cell In situ hybridization "These results suggest that miR-206 may associate both with nascent ribosomes in the nucleolus and with exported, functional ribosomes in the cytoplasm. " RLID00032322 MIMAT0000879 rno-miR-206-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000879 rno-miR-206 miRNA Rattus norvegicus 25092230 Circulating Plasma Microarray "From the above results, miRNAs were selected as candidate plasma miRNA biomarkers as follows: miR-208 (rno-miR- 208a-3p) for cardiotoxicity; miR-1 (rno-miR-1-3p), miR-133a (rno-miR-133a-3p), miR-133a* (rno-miR-133a-5p), and miR-133b (rno-miR-133b-3p) for shared cardiotoxicity and skeletal muscle toxicity; and miR- 206 (rno-miR-206-3p) for skeletal muscle toxicity. " RLID00032323 MIMAT0000879 rno-miR-206-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000879 rno-miR-206 miRNA Rattus norvegicus 17135348 Nucleolus Myogenic cell In situ hybridization "These results suggest that miR-206 may associate both with nascent ribosomes in the nucleolus and with exported, functional ribosomes in the cytoplasm. " RLID00032324 MIMAT0000879 rno-miR-206-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000879 rno-miR-206 miRNA Rattus norvegicus 17135348 Ribosome Myogenic cell In situ hybridization "These results suggest that miR-206 may associate both with nascent ribosomes in the nucleolus and with exported, functional ribosomes in the cytoplasm. " RLID00032325 MIMAT0000879 rno-miR-206-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000879 rno-miR-206 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032326 MIMAT0000879 rno-miR-206-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000879 rno-miR-206 miRNA Rattus norvegicus 20584895 Cell body Sympathetic neurons Microarray "However, a number of miRNAs were observed that were significantly enriched in the axons compared with the cell bodies, while others were enriched or present only in the cell bodies. For example, miR-204, miR-221, miR-15b, and miR-16 are characterized by the former pattern, while miR-297, miR-206, and miR-124a are examples of the latter pattern. " RLID00032327 MIMAT0000879 rno-miR-206-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000879 rno-miR-206 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032328 MIMAT0000881 rno-miR-210-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000881 rno-miR-210 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032329 MIMAT0000883 rno-miR-212-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000883 rno-miR-212 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032330 MIMAT0000885 rno-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000885 rno-miR-214 miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032331 MIMAT0000885 rno-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000885 rno-miR-214 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032332 MIMAT0000885 rno-miR-214-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000885 rno-miR-214 miRNA Rattus norvegicus 23682678 Circulating Serum qRT-PCR|Microarray "Generally,there were 25 up-regulated and seven down-regulated miRNAs between serum of ASH and control groups as well as 20 up-regulated and 14 down-regulated miRNAs between liver tissues of ASH and control groups (Table 2). Data are collected from Table 2. " RLID00032333 MIMAT0000888 rno-miR-218a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000888 "rno-miR-218, rno-miR-218a " miRNA Rattus norvegicus 19465924 Synapse Hippocampus In situ hybridization|Northern blot "The observed enrichment of several miRNAs in RNA preparations from synaptosomes was validated for selected candidates by Northern blot analysis (Fig. 2A). To monitor the subcellular localization of miRNAs identified in our screen, we performed in situ hybridization (ISH) in rat hippocampal neurons at 18 days in vitro (DIV) (Fig. 2B), using probes for miR-9, miR-218, miR-138 and miR-124 as a control (Fig. 2A, Suppl. Table 1). Data are collected from Figure 2. " RLID00032334 MIMAT0000888 rno-miR-218a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000888 "rno-miR-218, rno-miR-218a " miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032335 MIMAT0000890 rno-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000890 rno-miR-221 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032336 MIMAT0000890 rno-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000890 rno-miR-221 miRNA Rattus norvegicus 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00032337 MIMAT0000890 rno-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000890 rno-miR-221 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "However, a number of miRNAs were observed that were significantly enriched in the axons compared with the cell bodies, while others were enriched or present only in the cell bodies. For example, miR-204, miR-221, miR-15b, and miR-16 are characterized by the former pattern, while miR-297, miR-206, and miR-124a are examples of the latter pattern. " RLID00032338 MIMAT0000890 rno-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000890 rno-miR-221 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032339 MIMAT0000891 rno-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000891 rno-miR-222 miRNA Rattus norvegicus 21435393 Microvesicle Serum RT-PCR "By using RT-PCR and specific forward/reverse primers these microRNAs were all detected in microvesicles, that had been released from primary and differentiated rat adipocytes after 6 and 24h incubation, respectively, as well as in microvesicles from rat serum(Fig. 6; shown only for miR-16, miR-27a, miR-146b and miR-222). " RLID00032340 MIMAT0000891 rno-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000891 rno-miR-222 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032341 MIMAT0000891 rno-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000891 rno-miR-222 miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032342 MIMAT0000891 rno-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000891 rno-miR-222 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032343 MIMAT0000891 rno-miR-222-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000891 rno-miR-222 miRNA Rattus norvegicus 22529849 Exosome Adipocytes - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032344 MIMAT0000893 rno-miR-290 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000893 miRNA Rattus norvegicus 24553149 Circulating Plasma qRT-PCR|Microarray "Microarray assay results showed a total of 36 differentially-expressed miRNAs, among which 15 miRNAs were considered as aberrantly expressed with a more than 2-fold change when calculating the ratio of fluorescence intense between the 2 groups. The elevated miRNAs included miR-290, miR-874, miR-292-5p, miR-327, miR-374, miR-98, miR-352, miR-132, miR-146b, and miR-196a. The down-regulated miRNAs included miR-145, miR-329, miR-375, miR-140*, and miR-29a. Validation of microarray assay by qRT-PCR showed similar results and the ΔΔCt value compared to the sham group are shown in Figure 1. " RLID00032345 MIMAT0000894 rno-miR-291a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000894 rno-miR-291-5p miRNA Rattus norvegicus 23713256 Circulating Blood RT-PCR The RT-PCR result of the expression of miR-291a-5p with the peak time efficiency on day 7 showed that the expressions of miR-291a-5p in the peripheral blood and the liver tissue were basically identical. RLID00032346 MIMAT0000896 rno-miR-292-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000896 miRNA Rattus norvegicus 24553149 Circulating Plasma qRT-PCR|Microarray "Microarray assay results showed a total of 36 differentially-expressed miRNAs, among which 15 miRNAs were considered as aberrantly expressed with a more than 2-fold change when calculating the ratio of fluorescence intense between the 2 groups. The elevated miRNAs included miR-290, miR-874, miR-292-5p, miR-327, miR-374, miR-98, miR-352, miR-132, miR-146b, and miR-196a. The down-regulated miRNAs included miR-145, miR-329, miR-375, miR-140*, and miR-29a. Validation of microarray assay by qRT-PCR showed similar results and the ΔΔCt value compared to the sham group are shown in Figure 1. " RLID00032347 MIMAT0000898 rno-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000898 "rno-miR-296, rno-miR-296* " miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032348 MIMAT0000899 rno-miR-297 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000899 miRNA Rattus norvegicus 20584895 Cell body Sympathetic neurons Microarray "However, a number of miRNAs were observed that were significantly enriched in the axons compared with the cell bodies, while others were enriched or present only in the cell bodies. For example, miR-204, miR-221, miR-15b, and miR-16 are characterized by the former pattern, while miR-297, miR-206, and miR-124a are examples of the latter pattern. " RLID00032349 MIMAT0000899 rno-miR-297 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000899 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032350 MIMAT0000900 rno-miR-298-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000900 rno-miR-298 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032351 MIMAT0000900 rno-miR-298-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000900 rno-miR-298 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032352 MIMAT0000902 rno-miR-300-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000902 rno-miR-300 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032353 MIMAT0000903 rno-miR-320-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000903 rno-miR-320 miRNA Rattus norvegicus 24324399 Nucleus Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032354 MIMAT0000903 rno-miR-320-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000903 rno-miR-320 miRNA Rattus norvegicus 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00032355 MIMAT0000903 rno-miR-320-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000903 rno-miR-320 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032356 MIMAT0000903 rno-miR-320-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000903 rno-miR-320 miRNA Rattus norvegicus 19106625 Mitochondrion livers qRT-PCR|Microarray "To further define whether the miRNAs were present within the mitochondria, we used deoxycholic acid (DCA) to induce opening of the mitochondrial megapore channel33 and induction of the mitochondria permeability transition (MPT) in the isolated mitochondria.This disruption of mitochondrial integrity resulted in a significant loss of miRNAs by RT-PCR in the DCA treated mitochondria relative to the control vehicle group. The release of miR-130a and b, miR-320 and miR-494 was about 50% and that of miR-140 almost 80%. " RLID00032357 MIMAT0000903 rno-miR-320-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000903 rno-miR-320 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032358 MIMAT0000996 ebv-miR-BHRF1-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0000996 ebv-miR-BHRF1-2* miRNA Human herpesvirus 4 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00032359 MIMAT0001075 hsa-miR-384 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001075 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032360 MIMAT0001075 hsa-miR-384 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001075 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032361 MIMAT0001076 mmu-miR-384-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001076 mmu-miR-384 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00032362 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032363 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00032364 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032365 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032366 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00032367 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00032368 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032369 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032370 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032371 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR "Even under such stringent criteria, 11 miRNAs can be identified as miRNAs that are detectable in the nucleolus with very high levels of confidence (Figure 1D, Table S2). Since the detected nucleolar contents of many of these RNAs are very high, we termed these 11 miRNAs as nucleolar miRNAs. " RLID00032372 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032373 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032374 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00032375 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032376 MIMAT0001080 hsa-miR-196b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001080 hsa-miR-196b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032377 MIMAT0001090 mmu-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001090 mmu-miR-409 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00032378 MIMAT0001090 mmu-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001090 mmu-miR-409 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00032379 MIMAT0001091 mmu-miR-410-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001091 mmu-miR-410 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00032380 MIMAT0001092 mmu-miR-376b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001092 mmu-miR-376b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00032381 MIMAT0001095 mmu-miR-370-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001095 mmu-miR-370 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00032382 MIMAT0001095 mmu-miR-370-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001095 mmu-miR-370 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00032383 MIMAT0001095 mmu-miR-370-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001095 mmu-miR-370 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00032384 MIMAT0001320 rno-miR-421-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001320 rno-miR-421 miRNA Rattus norvegicus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00032385 MIMAT0001339 hsa-miR-422a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001339 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032386 MIMAT0001339 hsa-miR-422a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001339 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032387 MIMAT0001339 hsa-miR-422a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001339 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032388 MIMAT0001339 hsa-miR-422a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001339 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032389 MIMAT0001339 hsa-miR-422a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001339 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032390 MIMAT0001339 hsa-miR-422a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001339 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032391 MIMAT0001339 hsa-miR-422a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001339 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032392 MIMAT0001339 hsa-miR-422a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001339 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032393 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 21098710 Circulating Serum qRT-PCR "By selecting miRNAs that have 3-fold higher expression in HBV compared with control serum, we identified total of 13 upregulated miRNAs, including miR-375, miR-92a, miR-10a, miR-223, miR-423, miR-23b/a, miR-342-3p, miR-99a, miR-122a, miR-125b, miR-150, and let-7c. As shown in Figure 2, the upregulation of these 13 miRNA expressions in the serum of HBV cases, compared with those of controls, was largely consistent when detected by Solexa in pooled samples and qRT-PCR in individual samples. Data are collected from Figure 2. " RLID00032394 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032395 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032396 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00032397 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032398 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00032399 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032400 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032401 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032402 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032403 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00032404 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00032405 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00032406 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032407 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032408 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032409 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032410 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032411 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032412 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032413 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032414 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00032415 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00032416 MIMAT0001340 hsa-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001340 hsa-miR-423 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00032417 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032418 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032419 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032420 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032421 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032422 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00032423 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032424 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032425 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032426 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032427 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032428 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032429 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032430 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032431 MIMAT0001341 hsa-miR-424-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001341 hsa-miR-424 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00032432 MIMAT0001342 mmu-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001342 "mmu-miR-425, mmu-miR-425* " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00032433 MIMAT0001342 mmu-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001342 "mmu-miR-425, mmu-miR-425* " miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00032434 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032435 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032436 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00032437 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032438 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00032439 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032440 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00032441 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032442 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032443 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032444 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032445 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00032446 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00032447 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00032448 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032449 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032450 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032451 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00032452 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032453 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032454 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00032455 MIMAT0001343 hsa-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001343 "hsa-miR-425, hsa-miR-425-3p, hsa-miR-425* " miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032456 MIMAT0001412 hsa-miR-18b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001412 hsa-miR-18b miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00032457 MIMAT0001412 hsa-miR-18b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001412 hsa-miR-18b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032458 MIMAT0001412 hsa-miR-18b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001412 hsa-miR-18b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032459 MIMAT0001412 hsa-miR-18b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001412 hsa-miR-18b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032460 MIMAT0001412 hsa-miR-18b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001412 hsa-miR-18b miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00032461 MIMAT0001412 hsa-miR-18b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001412 hsa-miR-18b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032462 MIMAT0001412 hsa-miR-18b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001412 hsa-miR-18b miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00032463 MIMAT0001412 hsa-miR-18b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001412 hsa-miR-18b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00032464 MIMAT0001412 hsa-miR-18b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001412 hsa-miR-18b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032465 MIMAT0001412 hsa-miR-18b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001412 hsa-miR-18b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032466 MIMAT0001412 hsa-miR-18b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001412 hsa-miR-18b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032467 MIMAT0001412 hsa-miR-18b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001412 hsa-miR-18b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032468 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032469 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00032470 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032471 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032472 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032473 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00032474 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032475 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032476 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032477 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00032478 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00032479 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032480 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032481 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00032482 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032483 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00032484 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032485 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032486 MIMAT0001413 hsa-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001413 hsa-miR-20b miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032487 MIMAT0001419 mmu-miR-433-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001419 "mmu-miR-433-5p, mmu-miR-433* " miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00032488 MIMAT0001419 mmu-miR-433-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001419 "mmu-miR-433-5p, mmu-miR-433* " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00032489 MIMAT0001419 mmu-miR-433-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001419 "mmu-miR-433-5p, mmu-miR-433* " miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00032490 MIMAT0001421 mmu-miR-434-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001421 miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00032491 MIMAT0001422 mmu-miR-434-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001422 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00032492 MIMAT0001422 mmu-miR-434-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001422 miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00032493 MIMAT0001422 mmu-miR-434-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001422 miRNA Mus musculus 23897634 Cell body Neuron ball cultures Fluorescence in situ hybridization Data are collected from Table 2: Cell Body-Enriched miRNAs. RLID00032494 MIMAT0001532 hsa-miR-448 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001532 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032495 MIMAT0001532 hsa-miR-448 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001532 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032496 MIMAT0001532 hsa-miR-448 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001532 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032497 MIMAT0001532 hsa-miR-448 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001532 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032498 MIMAT0001532 hsa-miR-448 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001532 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00032499 MIMAT0001536 hsa-miR-429 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001536 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032500 MIMAT0001536 hsa-miR-429 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001536 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032501 MIMAT0001536 hsa-miR-429 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001536 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00032502 MIMAT0001536 hsa-miR-429 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001536 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032503 MIMAT0001536 hsa-miR-429 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001536 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032504 MIMAT0001537 mmu-miR-429-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001537 mmu-miR-429 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00032505 MIMAT0001541 hsa-miR-449a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001541 hsa-miR-449 miRNA Homo sapiens 23424776 Circulating Blood qRT-PCR|Microarray "Five miRNAs (let-7c, miR-16, miR- 449, miR-181a and miR-181b) were found to exhibit similar expression patterns (p < 0.05) in peripheral blood when compared to data obtained by using bone marrow aspirates from MM patients in other studies. " RLID00032506 MIMAT0001541 hsa-miR-449a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001541 hsa-miR-449 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032507 MIMAT0001541 hsa-miR-449a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001541 hsa-miR-449 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032508 MIMAT0001541 hsa-miR-449a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001541 hsa-miR-449 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032509 MIMAT0001541 hsa-miR-449a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001541 hsa-miR-449 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032510 MIMAT0001541 hsa-miR-449a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001541 hsa-miR-449 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032511 MIMAT0001541 hsa-miR-449a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001541 hsa-miR-449 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032512 MIMAT0001542 mmu-miR-449a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001542 "mmu-miR-449, mmu-miR-449a " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00032513 MIMAT0001545 hsa-miR-450a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001545 "hsa-miR-450, hsa-miR-450a " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032514 MIMAT0001545 hsa-miR-450a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001545 "hsa-miR-450, hsa-miR-450a " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032515 MIMAT0001545 hsa-miR-450a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001545 "hsa-miR-450, hsa-miR-450a " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032516 MIMAT0001545 hsa-miR-450a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001545 "hsa-miR-450, hsa-miR-450a " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032517 MIMAT0001546 mmu-miR-450a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001546 "mmu-miR-450, mmu-miR-450a-5p, mmu-miR-450a " miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00032518 MIMAT0001546 mmu-miR-450a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001546 "mmu-miR-450, mmu-miR-450a-5p, mmu-miR-450a " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00032519 MIMAT0001547 rno-miR-450a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001547 "rno-miR-450, rno-miR-450a " miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032520 MIMAT0001547 rno-miR-450a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001547 "rno-miR-450, rno-miR-450a " miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032521 MIMAT0001547 rno-miR-450a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001547 "rno-miR-450, rno-miR-450a " miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00032522 MIMAT0001577 hcmv-miR-UL112-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001577 "hcv-miR-UL112-1, hcmv-miR-UL112-1 " miRNA Human herpesvirus 5 21924071 Circulating Plasma Microarray "MiR-296-5p (Fold change 0.47, P = 0.013) and miR-133b (Fold change 0.57, P = 0.033) were consistently down-regulated in the patient plasma, whereas let-7e (Fold change 1.62, P = 0.009) and hcmv-miR-UL112 (Fold change 2.72, P = 0.004), one human cytomegalovirus encoded microRNAs, were up-regulated in the patient samples. " RLID00032523 MIMAT0001578 hcmv-miR-UL148D http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001578 "hcv-miR-UL148D-1, hcmv-miR-UL148D-1 " miRNA Human herpesvirus 5 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00032524 MIMAT0001618 hsa-miR-191-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001618 hsa-miR-191* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032525 MIMAT0001618 hsa-miR-191-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001618 hsa-miR-191* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00032526 MIMAT0001618 hsa-miR-191-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001618 hsa-miR-191* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032527 MIMAT0001618 hsa-miR-191-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001618 hsa-miR-191* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032528 MIMAT0001618 hsa-miR-191-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001618 hsa-miR-191* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032529 MIMAT0001620 hsa-miR-200a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001620 hsa-miR-200a* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032530 MIMAT0001620 hsa-miR-200a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001620 hsa-miR-200a* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00032531 MIMAT0001620 hsa-miR-200a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001620 hsa-miR-200a* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032532 MIMAT0001620 hsa-miR-200a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001620 hsa-miR-200a* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032533 MIMAT0001621 hsa-miR-369-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001621 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032534 MIMAT0001621 hsa-miR-369-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001621 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00032535 MIMAT0001621 hsa-miR-369-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001621 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032536 MIMAT0001621 hsa-miR-369-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001621 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032537 MIMAT0001621 hsa-miR-369-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001621 miRNA Homo sapiens 20668554 Microvesicle MSC cell qRT-PCR Table 5: Selectively expressed miRNAs from MSC MVs and their cells of origin. Data are collected from Table 5. RLID00032538 MIMAT0001625 hsa-miR-431-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001625 hsa-miR-431 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032539 MIMAT0001625 hsa-miR-431-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001625 hsa-miR-431 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032540 MIMAT0001625 hsa-miR-431-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001625 hsa-miR-431 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032541 MIMAT0001625 hsa-miR-431-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001625 hsa-miR-431 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00032542 MIMAT0001625 hsa-miR-431-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001625 hsa-miR-431 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032543 MIMAT0001626 rno-miR-431 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001626 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00032544 MIMAT0001627 hsa-miR-433-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001627 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00032545 MIMAT0001627 hsa-miR-433-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001627 miRNA Homo sapiens 25126405 Circulating Serum qRT-PCR "Circulating miRNAs in the serum and plasma are remarkably stable and are suggested to have promise as noninvasive biomarkers for neurological and neurodevelopmental disorders. Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated. " RLID00032546 MIMAT0001627 hsa-miR-433-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001627 miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00032547 MIMAT0001627 hsa-miR-433-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001627 miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00032548 MIMAT0001627 hsa-miR-433-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001627 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032549 MIMAT0001627 hsa-miR-433-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001627 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032550 MIMAT0001627 hsa-miR-433-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001627 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032551 MIMAT0001627 hsa-miR-433-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001627 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00032552 MIMAT0001627 hsa-miR-433-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001627 miRNA Homo sapiens 25238238 Circulating Serum qRT-PCR "Our study revealed that serum hsa-miR-206, hsa-miR-141-3p, hsa-miR-433-3p, hsa-miR-1228-5p, hsa-miR-199a-5p, hsa-miR-122-5p, hsa-miR-192-5p, and hsa-miR-26a-5p were potential circulating markers for HCC diagnosis. " RLID00032553 MIMAT0001627 hsa-miR-433-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001627 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032554 MIMAT0001627 hsa-miR-433-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001627 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032555 MIMAT0001628 rno-miR-433-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001628 rno-miR-433 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00032556 MIMAT0001629 hsa-miR-329-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001629 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032557 MIMAT0001629 hsa-miR-329-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001629 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032558 MIMAT0001629 hsa-miR-329-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001629 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032559 MIMAT0001629 hsa-miR-329-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001629 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032560 MIMAT0001629 hsa-miR-329-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001629 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00032561 MIMAT0001630 hsa-miR-323b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001630 hsa-miR-453 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 1: Ten miRNAs differentially expressed in both tumor tissue and serum. Data are collected from Table 1. RLID00032562 MIMAT0001630 hsa-miR-323b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001630 hsa-miR-453 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032563 MIMAT0001630 hsa-miR-323b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001630 hsa-miR-453 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032564 MIMAT0001630 hsa-miR-323b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001630 hsa-miR-453 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032565 MIMAT0001630 hsa-miR-323b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001630 hsa-miR-453 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032566 MIMAT0001630 hsa-miR-323b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001630 hsa-miR-453 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032567 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00032568 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00032569 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032570 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032571 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00032572 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00032573 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00032574 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032575 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032576 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 23169280 Circulating Serum Microarray "Table 2 miRNAs detected in pooled patient and control samples, as detected by Agilent Human miRNA microarrays. All of these showed potential as biomarkers as the levels of miRNAs varied between the patient and control groups. The expression levels of six of these miRNAs (in bold) were verified using TaqMan qRT–PCR. Three miRNAs (miR-720, miR-1246 and miR-1308) chosen for further analysis in individual patient samples. TaqMan qRT–PCR assays for the remaining three miRNAs were not available or were unreliable. Data are collected from Table 2. " RLID00032577 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032578 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032579 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00032580 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 25330373 Extracellular vesicle Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00032581 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00032582 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032583 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032584 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00032585 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 24633190 Circulating Plasma RT-PCR We also selected 1 miRNA (miR-150-5p) from these 3 mildly up-regulated miRNAs that expressed >= 50 copies in at least one group. The expression levels and the related functions of 8 selected miRNAs are shown in Table 2. Data are collected from Table 2. RLID00032586 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00032587 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00032588 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 22529849 Exosome HCC cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032589 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032590 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00032591 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032592 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 24130905 Circulating Plasma RT-PCR "Overall expression levels of circulating miRNAs: most miRNAs from the designated list were successfully detected (with Ct values between 18 and 35) in virtually all samples. The highest signal was detected for miR-451, -223, -15a, -486-5p, -16, and -21, which is in agreement with literature data " RLID00032593 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00032594 MIMAT0001631 hsa-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001631 hsa-miR-451 miRNA Homo sapiens 20668554 Microvesicle MSC cell qRT-PCR Table 5: Selectively expressed miRNAs from MSC MVs and their cells of origin. Data are collected from Table 5. RLID00032595 MIMAT0001632 mmu-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001632 mmu-miR-451 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00032596 MIMAT0001632 mmu-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001632 mmu-miR-451 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00032597 MIMAT0001632 mmu-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001632 mmu-miR-451 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00032598 MIMAT0001632 mmu-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001632 mmu-miR-451 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00032599 MIMAT0001632 mmu-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001632 mmu-miR-451 miRNA Mus musculus 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00032600 MIMAT0001632 mmu-miR-451a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001632 mmu-miR-451 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00032601 MIMAT0001633 rno-miR-451-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001633 rno-miR-451 miRNA Rattus norvegicus 18766170 Circulating Serum qRT-PCR "We also showed that miRNA let-7a, miR-21, miR-223, miR-451, miR-24, and miR-20a were detected in the serum of rats (Ra.S), mice (Mo.S), calves (Ca.S), bovine fetuses (FBS), and horses (Ho.S) (Figure 1B). Data are collected from Figure 1B. " RLID00032602 MIMAT0001635 hsa-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001635 hsa-miR-452 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032603 MIMAT0001635 hsa-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001635 hsa-miR-452 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032604 MIMAT0001635 hsa-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001635 hsa-miR-452 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032605 MIMAT0001635 hsa-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001635 hsa-miR-452 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032606 MIMAT0001635 hsa-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001635 hsa-miR-452 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032607 MIMAT0001635 hsa-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001635 hsa-miR-452 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032608 MIMAT0001635 hsa-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001635 hsa-miR-452 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032609 MIMAT0001635 hsa-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001635 hsa-miR-452 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032610 MIMAT0001635 hsa-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001635 hsa-miR-452 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032611 MIMAT0001635 hsa-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001635 hsa-miR-452 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032612 MIMAT0001635 hsa-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001635 hsa-miR-452 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032613 MIMAT0001635 hsa-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001635 hsa-miR-452 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00032614 MIMAT0001635 hsa-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001635 hsa-miR-452 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00032615 MIMAT0001635 hsa-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001635 hsa-miR-452 miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032616 MIMAT0001636 hsa-miR-452-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001636 hsa-miR-452* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032617 MIMAT0001637 mmu-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001637 mmu-miR-452 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00032618 MIMAT0001637 mmu-miR-452-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001637 mmu-miR-452 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00032619 MIMAT0001638 hsa-miR-409-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001638 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032620 MIMAT0001638 hsa-miR-409-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001638 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032621 MIMAT0001638 hsa-miR-409-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001638 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032622 MIMAT0001638 hsa-miR-409-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001638 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00032623 MIMAT0001638 hsa-miR-409-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001638 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032624 MIMAT0001639 hsa-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001639 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032625 MIMAT0001639 hsa-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001639 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032626 MIMAT0001639 hsa-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001639 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00032627 MIMAT0001639 hsa-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001639 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032628 MIMAT0001639 hsa-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001639 miRNA Homo sapiens 21505438 Exosome Primary dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032629 MIMAT0001639 hsa-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001639 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032630 MIMAT0001639 hsa-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001639 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032631 MIMAT0001639 hsa-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001639 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032632 MIMAT0001639 hsa-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001639 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00032633 MIMAT0001639 hsa-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001639 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032634 MIMAT0001639 hsa-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001639 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032635 MIMAT0001639 hsa-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001639 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00032636 MIMAT0001639 hsa-miR-409-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0001639 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00032637 MIMAT0002104 mmu-miR-463-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002104 "mmu-miR-463, mmu-miR-463* " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00032638 MIMAT0002107 mmu-miR-466a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002107 mmu-miR-466 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00032639 MIMAT0002108 mmu-miR-467a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002108 "mmu-miR-467, mmu-miR-467a, mmu-miR-467a*, mmu-miR-467a-1*, mmu-miR-467a* " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00032640 MIMAT0002109 mmu-miR-468-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002109 mmu-miR-468 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00032641 MIMAT0002111 mmu-miR-470-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002111 mmu-miR-470 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00032642 MIMAT0002118 ssc-miR-106a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002118 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032643 MIMAT0002119 ssc-miR-122 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002119 ssc-miR-122a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032644 MIMAT0002120 ssc-miR-125b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002120 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032645 MIMAT0002123 ssc-miR-145-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002123 ssc-miR-145 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032646 MIMAT0002124 ssc-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002124 ssc-miR-148a miRNA Sus scrofa 25158130 Extracellular vesicle Mesenchymal stem cell Next-generation sequencing "RNA-seq generated reads for at least 386 annotated miRNAs, but only miR148a, miR532-5p, miR378, and let-7f were enriched in EVs compared to MSCs. " RLID00032647 MIMAT0002124 ssc-miR-148a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002124 ssc-miR-148a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032648 MIMAT0002125 ssc-miR-15b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002125 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032649 MIMAT0002126 ssc-miR-181b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002126 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032650 MIMAT0002127 ssc-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002127 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032651 MIMAT0002133 ssc-miR-23a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002133 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032652 MIMAT0002134 ssc-miR-24-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002134 ssc-miR-24 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032653 MIMAT0002135 ssc-miR-26a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002135 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032654 MIMAT0002137 ssc-miR-29b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002137 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032655 MIMAT0002139 ssc-miR-323 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002139 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032656 MIMAT0002140 ssc-miR-326 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002140 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032657 MIMAT0002141 ssc-miR-7 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002141 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032658 MIMAT0002144 ssc-miR-181c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002144 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032659 MIMAT0002145 ssc-miR-183 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002145 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032660 MIMAT0002146 ssc-miR-205 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002146 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032661 MIMAT0002148 ssc-miR-27a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002148 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032662 MIMAT0002151 ssc-let-7c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002151 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032663 MIMAT0002152 ssc-let-7f http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002152 miRNA Sus scrofa 25158130 Extracellular vesicle Mesenchymal stem cell Next-generation sequencing "RNA-seq generated reads for at least 386 annotated miRNAs, but only miR148a, miR532-5p, miR378, and let-7f were enriched in EVs compared to MSCs. " RLID00032664 MIMAT0002152 ssc-let-7f http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002152 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032665 MIMAT0002153 ssc-let-7i http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002153 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032666 MIMAT0002154 ssc-miR-103 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002154 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032667 MIMAT0002155 ssc-miR-107 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002155 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032668 MIMAT0002156 ssc-miR-124a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002156 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032669 MIMAT0002157 ssc-miR-128 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002157 ssc-miR-128a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032670 MIMAT0002159 ssc-miR-139-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002159 ssc-miR-139 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032671 MIMAT0002161 ssc-miR-18a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002161 ssc-miR-18 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032672 MIMAT0002162 ssc-miR-186 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002162 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032673 MIMAT0002164 ssc-miR-204 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002164 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032674 MIMAT0002165 ssc-miR-21 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002165 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032675 MIMAT0002166 ssc-miR-29c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002166 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032676 MIMAT0002167 ssc-miR-30c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002167 ssc-miR-30c miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032677 MIMAT0002168 ssc-miR-9-1 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002168 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032678 MIMAT0002169 ssc-miR-9-2 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002169 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00032679 MIMAT0002170 hsa-miR-412-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002170 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032680 MIMAT0002170 hsa-miR-412-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002170 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032681 MIMAT0002171 hsa-miR-410-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002171 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032682 MIMAT0002171 hsa-miR-410-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002171 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032683 MIMAT0002171 hsa-miR-410-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002171 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032684 MIMAT0002171 hsa-miR-410-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002171 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032685 MIMAT0002171 hsa-miR-410-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002171 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00032686 MIMAT0002172 hsa-miR-376b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002172 hsa-miR-376b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032687 MIMAT0002172 hsa-miR-376b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002172 hsa-miR-376b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032688 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 24961598 Circulating Plasma qRT-PCR "This is the first report of circulating miR biomarkers in LVAD patients. We demonstrate the feasibility of this approach, report the potential for miR-483-3p and miR-1202, respectively, to monitor and predict response to LVAD therapy, and propose further work to study these hypotheses and elucidate roles for miR-483-3p and miR-1202 in clinical practice and in underlying biological processes. " RLID00032689 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032690 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00032691 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 21505438 Exosome Primary dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032692 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032693 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032694 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00032695 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032696 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00032697 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032698 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 24577456 Circulating Serum Next-generation sequencing The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. Table 2 has displayed the data. RLID00032699 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032700 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032701 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00032702 MIMAT0002173 hsa-miR-483-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002173 hsa-miR-483 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032703 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00032704 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032705 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032706 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032707 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00032708 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032709 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 21505438 Exosome Primary dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032710 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032711 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032712 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032713 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00032714 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032715 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032716 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR "Even under such stringent criteria, 11 miRNAs can be identified as miRNAs that are detectable in the nucleolus with very high levels of confidence (Figure 1D, Table S2). Since the detected nucleolar contents of many of these RNAs are very high, we termed these 11 miRNAs as nucleolar miRNAs. " RLID00032717 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032718 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00032719 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032720 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032721 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032722 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032723 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 24865854 Circulating Plasma qRT-PCR|Next-generation sequcencing "Further exploration of their levels in the plasma of CAD patient and control cases, only circulating miR-361-5p and miR-484 were more abundant in CAD cases by RT-qPCR (Fig. 2D). Levels of circulating miR-140-5p showed no different between healthy and disease population (Fig. 2D). Moreover, levels of miR-342-3p, miR-125b-5p, miR-34a-5p, miR-103a-3p, and miR-125a-5p were even reduced significantly in patient circulation (Fig. 2D). " RLID00032724 MIMAT0002174 hsa-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002174 miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR|In situ hybridization "Through in situ hybridisation, we have localised these miRNAs, including miR-191 and miR-484, in the nucleolus of a diversity of human and rodent cell lines. Four cleolar miRNAs; miR191, miR-484, miR-574-3p and miR-193b, were tested in our ISH experiments, and all four miRNAs exhibit strong nucleolar localisation (Figure 2A). " RLID00032725 MIMAT0002175 hsa-miR-485-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002175 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032726 MIMAT0002175 hsa-miR-485-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002175 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00032727 MIMAT0002175 hsa-miR-485-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002175 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 1: Ten miRNAs differentially expressed in both tumor tissue and serum. Data are collected from Table 1. RLID00032728 MIMAT0002175 hsa-miR-485-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002175 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032729 MIMAT0002175 hsa-miR-485-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002175 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032730 MIMAT0002175 hsa-miR-485-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002175 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032731 MIMAT0002175 hsa-miR-485-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002175 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00032732 MIMAT0002175 hsa-miR-485-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002175 miRNA Homo sapiens 24577456 Circulating Serum Next-generation sequencing The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. Table 2 has displayed the data. RLID00032733 MIMAT0002175 hsa-miR-485-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002175 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00032734 MIMAT0002176 hsa-miR-485-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002176 miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00032735 MIMAT0002176 hsa-miR-485-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002176 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00032736 MIMAT0002176 hsa-miR-485-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002176 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032737 MIMAT0002176 hsa-miR-485-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002176 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032738 MIMAT0002176 hsa-miR-485-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002176 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032739 MIMAT0002176 hsa-miR-485-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002176 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032740 MIMAT0002176 hsa-miR-485-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002176 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032741 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00032742 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 20194856 Circulating Serum Next-generation sequencing "Endogenous circulating miRNAs are stable, are well protected from RNases, and remain stable even after being subjected to harsh conditions. Eleven serum miRNAs were found to be altered more than five-fold by Solexa sequencing between longer-survival and shorter-survival groups, and levels of four miRNAs (ie, miR-486, miR-30d, miR-1 and miR-501) were significantly associated with overall survival. " RLID00032743 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00032744 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032745 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032746 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00032747 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 24981880 Circulating Serum qRT-PCR "Results from recent studies revealed that circulating miRNAs are also potential diagnostic biomarkers and prognostic factors in diabetes. The results of qRT-PCR assessment revealed low serum levels of miR-23a, let-7i, miR-486, miR-96, miR-186, miR-191, miR-192, and miR-146a in T2D. " RLID00032748 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032749 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00032750 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032751 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032752 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032753 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032754 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00032755 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00032756 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032757 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032758 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032759 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00032760 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00032761 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032762 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032763 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 25793394 Cytoplasm GC cell In situ hybridization miR-486-5p was mainly located in the cytoplasm of GC cells and neighboring normal tissues. RLID00032764 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032765 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032766 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00032767 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 24130905 Circulating Plasma RT-PCR "Overall expression levels of circulating miRNAs: most miRNAs from the designated list were successfully detected (with Ct values between 18 and 35) in virtually all samples. The highest signal was detected for miR-451, -223, -15a, -486-5p, -16, and -21, which is in agreement with literature data " RLID00032768 MIMAT0002177 hsa-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002177 hsa-miR-486 miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00032769 MIMAT0002178 hsa-miR-487a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002178 hsa-miR-487 miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00032770 MIMAT0002178 hsa-miR-487a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002178 hsa-miR-487 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032771 MIMAT0002178 hsa-miR-487a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002178 hsa-miR-487 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032772 MIMAT0002178 hsa-miR-487a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002178 hsa-miR-487 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032773 MIMAT0002193 kshv-miR-K12-3-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002193 kshv-miR-K12-3 miRNA Human herpesvirus 8 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00032774 MIMAT0002194 kshv-miR-K12-3-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002194 kshv-miR-K12-3* miRNA Human herpesvirus 8 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00032775 MIMAT0002805 hsa-miR-489-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002805 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00032776 MIMAT0002805 hsa-miR-489-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002805 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032777 MIMAT0002805 hsa-miR-489-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002805 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032778 MIMAT0002806 hsa-miR-490-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002806 hsa-miR-490 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032779 MIMAT0002806 hsa-miR-490-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002806 hsa-miR-490 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032780 MIMAT0002806 hsa-miR-490-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002806 hsa-miR-490 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032781 MIMAT0002807 hsa-miR-491-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002807 hsa-miR-491 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032782 MIMAT0002807 hsa-miR-491-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002807 hsa-miR-491 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032783 MIMAT0002807 hsa-miR-491-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002807 hsa-miR-491 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032784 MIMAT0002807 hsa-miR-491-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002807 hsa-miR-491 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032785 MIMAT0002808 hsa-miR-511-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002808 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032786 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00032787 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032788 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032789 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00032790 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032791 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032792 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00032793 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032794 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032795 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032796 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032797 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032798 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032799 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032800 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032801 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032802 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table4. Forty Most Highly Expressed miRNAs of Exosome I, Exosome II and WS. Data are collected from Table 4. " RLID00032803 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032804 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032805 MIMAT0002809 hsa-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002809 hsa-miR-146b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00032806 MIMAT0002810 hsa-miR-202-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002810 hsa-miR-202* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032807 MIMAT0002811 hsa-miR-202-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002811 hsa-miR-202 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032808 MIMAT0002811 hsa-miR-202-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002811 hsa-miR-202 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032809 MIMAT0002811 hsa-miR-202-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002811 hsa-miR-202 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032810 MIMAT0002811 hsa-miR-202-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002811 hsa-miR-202 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032811 MIMAT0002811 hsa-miR-202-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002811 hsa-miR-202 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00032812 MIMAT0002811 hsa-miR-202-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002811 hsa-miR-202 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032813 MIMAT0002811 hsa-miR-202-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002811 hsa-miR-202 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032814 MIMAT0002812 hsa-miR-492 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002812 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032815 MIMAT0002812 hsa-miR-492 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002812 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032816 MIMAT0002812 hsa-miR-492 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002812 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032817 MIMAT0002813 hsa-miR-493-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002813 "hsa-miR-493, hsa-miR-493-5p, hsa-miR-493* " miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00032818 MIMAT0002813 hsa-miR-493-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002813 "hsa-miR-493, hsa-miR-493-5p, hsa-miR-493* " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032819 MIMAT0002813 hsa-miR-493-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002813 "hsa-miR-493, hsa-miR-493-5p, hsa-miR-493* " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032820 MIMAT0002813 hsa-miR-493-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002813 "hsa-miR-493, hsa-miR-493-5p, hsa-miR-493* " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032821 MIMAT0002813 hsa-miR-493-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002813 "hsa-miR-493, hsa-miR-493-5p, hsa-miR-493* " miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00032822 MIMAT0002813 hsa-miR-493-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002813 "hsa-miR-493, hsa-miR-493-5p, hsa-miR-493* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032823 MIMAT0002814 hsa-miR-432-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002814 hsa-miR-432 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032824 MIMAT0002814 hsa-miR-432-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002814 hsa-miR-432 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00032825 MIMAT0002814 hsa-miR-432-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002814 hsa-miR-432 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00032826 MIMAT0002814 hsa-miR-432-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002814 hsa-miR-432 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032827 MIMAT0002814 hsa-miR-432-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002814 hsa-miR-432 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032828 MIMAT0002814 hsa-miR-432-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002814 hsa-miR-432 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032829 MIMAT0002814 hsa-miR-432-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002814 hsa-miR-432 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032830 MIMAT0002814 hsa-miR-432-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002814 hsa-miR-432 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032831 MIMAT0002814 hsa-miR-432-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002814 hsa-miR-432 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032832 MIMAT0002814 hsa-miR-432-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002814 hsa-miR-432 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00032833 MIMAT0002814 hsa-miR-432-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002814 hsa-miR-432 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00032834 MIMAT0002814 hsa-miR-432-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002814 hsa-miR-432 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032835 MIMAT0002814 hsa-miR-432-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002814 hsa-miR-432 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032836 MIMAT0002814 hsa-miR-432-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002814 hsa-miR-432 miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00032837 MIMAT0002815 hsa-miR-432-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002815 hsa-miR-432* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032838 MIMAT0002815 hsa-miR-432-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002815 hsa-miR-432* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032839 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00032840 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032841 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032842 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00032843 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032844 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032845 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032846 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032847 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00032848 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00032849 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032850 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell RT-PCR|Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00032851 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00032852 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032853 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032854 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray|RT-PCR "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00032855 MIMAT0002816 hsa-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002816 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032856 MIMAT0002817 hsa-miR-495-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002817 hsa-miR-495 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032857 MIMAT0002817 hsa-miR-495-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002817 hsa-miR-495 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032858 MIMAT0002817 hsa-miR-495-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002817 hsa-miR-495 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032859 MIMAT0002817 hsa-miR-495-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002817 hsa-miR-495 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032860 MIMAT0002817 hsa-miR-495-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002817 hsa-miR-495 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032861 MIMAT0002817 hsa-miR-495-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002817 hsa-miR-495 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00032862 MIMAT0002818 hsa-miR-496 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002818 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032863 MIMAT0002818 hsa-miR-496 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002818 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032864 MIMAT0002818 hsa-miR-496 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002818 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032865 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032866 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032867 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032868 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00032869 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00032870 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032871 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032872 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032873 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032874 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032875 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032876 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00032877 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032878 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032879 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032880 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032881 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR "Even under such stringent criteria, 11 miRNAs can be identified as miRNAs that are detectable in the nucleolus with very high levels of confidence (Figure 1D, Table S2). Since the detected nucleolar contents of many of these RNAs are very high, we termed these 11 miRNAs as nucleolar miRNAs. " RLID00032882 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032883 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00032884 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032885 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032886 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032887 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032888 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR|In situ hybridization "Four nucleolar miRNAs; miR191, miR-484, miR-574-3p and miR-193b, were tested in our ISH experiments, and all four miRNAs exhibit strong nucleolar localisation (Figure 2A). " RLID00032889 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032890 MIMAT0002819 hsa-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002819 hsa-miR-193b miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032891 MIMAT0002820 hsa-miR-497-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002820 hsa-miR-497 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032892 MIMAT0002820 hsa-miR-497-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002820 hsa-miR-497 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00032893 MIMAT0002820 hsa-miR-497-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002820 hsa-miR-497 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00032894 MIMAT0002820 hsa-miR-497-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002820 hsa-miR-497 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032895 MIMAT0002820 hsa-miR-497-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002820 hsa-miR-497 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032896 MIMAT0002820 hsa-miR-497-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002820 hsa-miR-497 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00032897 MIMAT0002820 hsa-miR-497-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002820 hsa-miR-497 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032898 MIMAT0002820 hsa-miR-497-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002820 hsa-miR-497 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00032899 MIMAT0002820 hsa-miR-497-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002820 hsa-miR-497 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00032900 MIMAT0002820 hsa-miR-497-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002820 hsa-miR-497 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032901 MIMAT0002820 hsa-miR-497-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002820 hsa-miR-497 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00032902 MIMAT0002820 hsa-miR-497-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002820 hsa-miR-497 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032903 MIMAT0002820 hsa-miR-497-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002820 hsa-miR-497 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00032904 MIMAT0002821 hsa-miR-181d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002821 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032905 MIMAT0002821 hsa-miR-181d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002821 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032906 MIMAT0002821 hsa-miR-181d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002821 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032907 MIMAT0002821 hsa-miR-181d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002821 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00032908 MIMAT0002821 hsa-miR-181d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002821 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00032909 MIMAT0002821 hsa-miR-181d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002821 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032910 MIMAT0002821 hsa-miR-181d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002821 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00032911 MIMAT0002821 hsa-miR-181d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002821 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00032912 MIMAT0002821 hsa-miR-181d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002821 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032913 MIMAT0002821 hsa-miR-181d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002821 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00032914 MIMAT0002821 hsa-miR-181d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002821 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032915 MIMAT0002821 hsa-miR-181d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002821 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00032916 MIMAT0002822 hsa-miR-512-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002822 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032917 MIMAT0002822 hsa-miR-512-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002822 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032918 MIMAT0002823 hsa-miR-512-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002823 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032919 MIMAT0002823 hsa-miR-512-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002823 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032920 MIMAT0002824 hsa-miR-498 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002824 miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00032921 MIMAT0002824 hsa-miR-498 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002824 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032922 MIMAT0002824 hsa-miR-498 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002824 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00032923 MIMAT0002824 hsa-miR-498 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002824 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032924 MIMAT0002824 hsa-miR-498 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002824 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00032925 MIMAT0002824 hsa-miR-498 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002824 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032926 MIMAT0002825 hsa-miR-520e http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002825 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032927 MIMAT0002825 hsa-miR-520e http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002825 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032928 MIMAT0002826 hsa-miR-515-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002826 miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00032929 MIMAT0002826 hsa-miR-515-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002826 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032930 MIMAT0002826 hsa-miR-515-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002826 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00032931 MIMAT0002826 hsa-miR-515-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002826 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00032932 MIMAT0002826 hsa-miR-515-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002826 miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032933 MIMAT0002827 hsa-miR-515-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002827 miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00032934 MIMAT0002827 hsa-miR-515-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002827 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032935 MIMAT0002828 hsa-miR-519e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002828 hsa-miR-519e* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032936 MIMAT0002828 hsa-miR-519e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002828 hsa-miR-519e* miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00032937 MIMAT0002828 hsa-miR-519e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002828 hsa-miR-519e* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032938 MIMAT0002829 hsa-miR-519e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002829 hsa-miR-519e miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032939 MIMAT0002830 hsa-miR-520f-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002830 miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00032940 MIMAT0002830 hsa-miR-520f-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002830 miRNA Homo sapiens 22529849 Exosome HCC cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032941 MIMAT0002831 hsa-miR-519c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002831 hsa-miR-526c miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032942 MIMAT0002831 hsa-miR-519c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002831 hsa-miR-526c miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032943 MIMAT0002832 hsa-miR-519c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002832 hsa-miR-519c miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032944 MIMAT0002833 hsa-miR-520a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002833 hsa-miR-520a* miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00032945 MIMAT0002833 hsa-miR-520a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002833 hsa-miR-520a* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032946 MIMAT0002834 hsa-miR-520a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002834 hsa-miR-520a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032947 MIMAT0002834 hsa-miR-520a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002834 hsa-miR-520a miRNA Homo sapiens 25017274 Circulating Serum qRT-PCR "The expression of four miRNAs (miR-1233, miR-520, miR-210, miR-144) was validated by quantitative real-time polymerase chain reaction analysis. MiR-1233 was the most overexpressed in the serum of women who later developed sPE. Circulating miRNAs deserve further investigation in order to explore their potential role in the pathogenesis of preeclampsia. In particular, miR-1233 might represent a potential marker of early sPE. " RLID00032948 MIMAT0002835 hsa-miR-526b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002835 hsa-miR-526b miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00032949 MIMAT0002835 hsa-miR-526b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002835 hsa-miR-526b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032950 MIMAT0002835 hsa-miR-526b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002835 hsa-miR-526b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032951 MIMAT0002836 hsa-miR-526b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002836 hsa-miR-526b* miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00032952 MIMAT0002836 hsa-miR-526b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002836 hsa-miR-526b* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032953 MIMAT0002837 hsa-miR-519b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002837 hsa-miR-519b miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032954 MIMAT0002838 hsa-miR-525-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002838 hsa-miR-525 miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00032955 MIMAT0002838 hsa-miR-525-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002838 hsa-miR-525 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032956 MIMAT0002838 hsa-miR-525-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002838 hsa-miR-525 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00032957 MIMAT0002839 hsa-miR-525-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002839 hsa-miR-525* miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00032958 MIMAT0002839 hsa-miR-525-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002839 hsa-miR-525* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032959 MIMAT0002840 hsa-miR-523-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002840 hsa-miR-523 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032960 MIMAT0002840 hsa-miR-523-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002840 hsa-miR-523 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032961 MIMAT0002840 hsa-miR-523-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002840 hsa-miR-523 miRNA Homo sapiens 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00032962 MIMAT0002840 hsa-miR-523-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002840 hsa-miR-523 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00032963 MIMAT0002840 hsa-miR-523-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002840 hsa-miR-523 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032964 MIMAT0002841 hsa-miR-518f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002841 hsa-miR-518f* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032965 MIMAT0002841 hsa-miR-518f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002841 hsa-miR-518f* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032966 MIMAT0002842 hsa-miR-518f-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002842 hsa-miR-518f miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032967 MIMAT0002842 hsa-miR-518f-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002842 hsa-miR-518f miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032968 MIMAT0002842 hsa-miR-518f-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002842 hsa-miR-518f miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032969 MIMAT0002843 hsa-miR-520b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002843 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032970 MIMAT0002843 hsa-miR-520b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002843 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032971 MIMAT0002843 hsa-miR-520b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002843 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032972 MIMAT0002844 hsa-miR-518b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002844 miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00032973 MIMAT0002844 hsa-miR-518b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002844 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032974 MIMAT0002844 hsa-miR-518b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002844 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00032975 MIMAT0002845 hsa-miR-526a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002845 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032976 MIMAT0002845 hsa-miR-526a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002845 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032977 MIMAT0002845 hsa-miR-526a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002845 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032978 MIMAT0002846 hsa-miR-520c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002846 hsa-miR-520c miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032979 MIMAT0002846 hsa-miR-520c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002846 hsa-miR-520c miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032980 MIMAT0002846 hsa-miR-520c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002846 hsa-miR-520c miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00032981 MIMAT0002847 hsa-miR-518c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002847 hsa-miR-518c* miRNA Homo sapiens 20145944 Circulating Saliva RT-PCR|Microarray "Also the miRNAs, miR-583, miR-518c*, and miR-208b identified by microarray analysis as candidate markers for saliva and miR-617 for vaginal secretion, demonstrated a strong discordance between microarray and TaqMan data (Electronic supplementary materials, Fig. 2). " RLID00032982 MIMAT0002847 hsa-miR-518c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002847 hsa-miR-518c* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00032983 MIMAT0002847 hsa-miR-518c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002847 hsa-miR-518c* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032984 MIMAT0002847 hsa-miR-518c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002847 hsa-miR-518c* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00032985 MIMAT0002848 hsa-miR-518c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002848 hsa-miR-518c miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00032986 MIMAT0002848 hsa-miR-518c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002848 hsa-miR-518c miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032987 MIMAT0002849 hsa-miR-524-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002849 hsa-miR-524* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032988 MIMAT0002849 hsa-miR-524-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002849 hsa-miR-524* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00032989 MIMAT0002851 hsa-miR-517-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002851 hsa-miR-517* miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00032990 MIMAT0002851 hsa-miR-517-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002851 hsa-miR-517* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032991 MIMAT0002852 hsa-miR-517a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002852 hsa-miR-517a miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00032992 MIMAT0002852 hsa-miR-517a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002852 hsa-miR-517a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032993 MIMAT0002852 hsa-miR-517a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002852 hsa-miR-517a miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00032994 MIMAT0002852 hsa-miR-517a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002852 hsa-miR-517a miRNA Homo sapiens 22529849 Exosome Placenta - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00032995 MIMAT0002854 hsa-miR-521 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002854 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00032996 MIMAT0002854 hsa-miR-521 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002854 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032997 MIMAT0002855 hsa-miR-520d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002855 hsa-miR-520d* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032998 MIMAT0002856 hsa-miR-520d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002856 hsa-miR-520d miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00032999 MIMAT0002857 hsa-miR-517b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002857 hsa-miR-517b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033000 MIMAT0002858 hsa-miR-520g-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002858 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033001 MIMAT0002859 hsa-miR-516b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002859 "hsa-miR-516-5p, hsa-miR-516b " miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033002 MIMAT0002859 hsa-miR-516b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002859 "hsa-miR-516-5p, hsa-miR-516b " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033003 MIMAT0002859 hsa-miR-516b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002859 "hsa-miR-516-5p, hsa-miR-516b " miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00033004 MIMAT0002859 hsa-miR-516b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002859 "hsa-miR-516-5p, hsa-miR-516b " miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033005 MIMAT0002860 hsa-miR-516b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002860 "hsa-miR-516-3p, hsa-miR-516b*, hsa-miR-516a-3p, hsa-miR-516b*, hsa-miR-516a-3p, hsa-miR-516b* " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033006 MIMAT0002861 hsa-miR-518e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002861 hsa-miR-518e miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00033007 MIMAT0002861 hsa-miR-518e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002861 hsa-miR-518e miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033008 MIMAT0002862 hsa-miR-527 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002862 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033009 MIMAT0002862 hsa-miR-527 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002862 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033010 MIMAT0002862 hsa-miR-527 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002862 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033011 MIMAT0002862 hsa-miR-527 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002862 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033012 MIMAT0002863 hsa-miR-518a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002863 hsa-miR-518a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033013 MIMAT0002864 hsa-miR-518d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002864 hsa-miR-518d miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033014 MIMAT0002864 hsa-miR-518d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002864 hsa-miR-518d miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033015 MIMAT0002864 hsa-miR-518d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002864 hsa-miR-518d miRNA Homo sapiens 22529849 Exosome HCC cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033016 MIMAT0002866 hsa-miR-517c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002866 hsa-miR-517c miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00033017 MIMAT0002866 hsa-miR-517c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002866 hsa-miR-517c miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033018 MIMAT0002866 hsa-miR-517c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002866 hsa-miR-517c miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033019 MIMAT0002866 hsa-miR-517c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002866 hsa-miR-517c miRNA Homo sapiens 22529849 Exosome HCC cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033020 MIMAT0002867 hsa-miR-520h http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002867 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033021 MIMAT0002868 hsa-miR-522-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002868 hsa-miR-522 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033022 MIMAT0002868 hsa-miR-522-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002868 hsa-miR-522 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033023 MIMAT0002868 hsa-miR-522-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002868 hsa-miR-522 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033024 MIMAT0002869 hsa-miR-519a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002869 hsa-miR-519a miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00033025 MIMAT0002869 hsa-miR-519a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002869 hsa-miR-519a miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033026 MIMAT0002870 hsa-miR-499a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002870 "hsa-miR-499, hsa-miR-499-5p " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00033027 MIMAT0002870 hsa-miR-499a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002870 "hsa-miR-499, hsa-miR-499-5p " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033028 MIMAT0002870 hsa-miR-499a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002870 "hsa-miR-499, hsa-miR-499-5p " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033029 MIMAT0002870 hsa-miR-499a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002870 "hsa-miR-499, hsa-miR-499-5p " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033030 MIMAT0002870 hsa-miR-499a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002870 "hsa-miR-499, hsa-miR-499-5p " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00033031 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033032 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033033 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00033034 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00033035 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033036 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033037 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033038 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033039 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033040 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033041 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00033042 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00033043 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033044 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033045 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033046 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033047 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033048 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00033049 MIMAT0002871 hsa-miR-500a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002871 "hsa-miR-500, hsa-miR-500*, hsa-miR-500a* " miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033050 MIMAT0002872 hsa-miR-501-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002872 hsa-miR-501 miRNA Homo sapiens 20194856 Circulating Serum Next-generation sequencing "Endogenous circulating miRNAs are stable, are well protected from RNases, and remain stable even after being subjected to harsh conditions. Eleven serum miRNAs were found to be altered more than five-fold by Solexa sequencing between longer-survival and shorter-survival groups, and levels of four miRNAs (ie, miR-486, miR-30d, miR-1 and miR-501) were significantly associated with overall survival. " RLID00033051 MIMAT0002872 hsa-miR-501-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002872 hsa-miR-501 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033052 MIMAT0002872 hsa-miR-501-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002872 hsa-miR-501 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033053 MIMAT0002872 hsa-miR-501-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002872 hsa-miR-501 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033054 MIMAT0002872 hsa-miR-501-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002872 hsa-miR-501 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00033055 MIMAT0002872 hsa-miR-501-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002872 hsa-miR-501 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033056 MIMAT0002872 hsa-miR-501-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002872 hsa-miR-501 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033057 MIMAT0002872 hsa-miR-501-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002872 hsa-miR-501 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033058 MIMAT0002872 hsa-miR-501-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002872 hsa-miR-501 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033059 MIMAT0002872 hsa-miR-501-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002872 hsa-miR-501 miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00033060 MIMAT0002873 hsa-miR-502-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002873 hsa-miR-502 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033061 MIMAT0002873 hsa-miR-502-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002873 hsa-miR-502 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033062 MIMAT0002873 hsa-miR-502-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002873 hsa-miR-502 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033063 MIMAT0002873 hsa-miR-502-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002873 hsa-miR-502 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033064 MIMAT0002873 hsa-miR-502-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002873 hsa-miR-502 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033065 MIMAT0002873 hsa-miR-502-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002873 hsa-miR-502 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00033066 MIMAT0002873 hsa-miR-502-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002873 hsa-miR-502 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033067 MIMAT0002873 hsa-miR-502-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002873 hsa-miR-502 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033068 MIMAT0002873 hsa-miR-502-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002873 hsa-miR-502 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033069 MIMAT0002873 hsa-miR-502-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002873 hsa-miR-502 miRNA Homo sapiens 20668554 Microvesicle MSC cell qRT-PCR Table 5: Selectively expressed miRNAs from MSC MVs and their cells of origin. Data are collected from Table 5. RLID00033070 MIMAT0002873 hsa-miR-502-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002873 hsa-miR-502 miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00033071 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00033072 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033073 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033074 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033075 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033076 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033077 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033078 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033079 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033080 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033081 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033082 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033083 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033084 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033085 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00033086 MIMAT0002874 hsa-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002874 hsa-miR-503 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033087 MIMAT0002875 hsa-miR-504-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002875 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00033088 MIMAT0002875 hsa-miR-504-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002875 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033089 MIMAT0002875 hsa-miR-504-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002875 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033090 MIMAT0002875 hsa-miR-504-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002875 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033091 MIMAT0002875 hsa-miR-504-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002875 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033092 MIMAT0002876 hsa-miR-505-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002876 hsa-miR-505 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033093 MIMAT0002876 hsa-miR-505-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002876 hsa-miR-505 miRNA Homo sapiens 23938262 Circulating Plasma RT-PCR|Microarray "Plasma-based circulating MicroRNA biomarkers for Parkinson's disease. We identified 9 pairs of PD-predictive classifiers using k-TSP analysis and 13 most differentially-expressed miRNAs by SAM. A combination of both data sets produced a panel of PD-predictive biomarkers: k-TSP1 (miR-1826/miR-450b-3p), miR-626, and miR-505, and achieved the highest predictive power of 91% sensitivity, 100% specificity, 100% positive predicted value, and 88% negative predicted value in the replication set. However, low predictive values were shown in the validation set. " RLID00033094 MIMAT0002876 hsa-miR-505-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002876 hsa-miR-505 miRNA Homo sapiens 25405200 Circulating Serum qRT-PCR "Individual qRT-PCR results (expression level) of serum miRNA expression in macrosomia and controls is shown in Table 3, including has-miR-122, has-miR-192, has-miR-194, has-miR-296-5p, has-miR-376a, has-miR-487b, has-miR-505, has-miR-1262 " RLID00033095 MIMAT0002876 hsa-miR-505-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002876 hsa-miR-505 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033096 MIMAT0002876 hsa-miR-505-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002876 hsa-miR-505 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00033097 MIMAT0002876 hsa-miR-505-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002876 hsa-miR-505 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033098 MIMAT0002876 hsa-miR-505-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002876 hsa-miR-505 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033099 MIMAT0002876 hsa-miR-505-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002876 hsa-miR-505 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033100 MIMAT0002876 hsa-miR-505-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002876 hsa-miR-505 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033101 MIMAT0002876 hsa-miR-505-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002876 hsa-miR-505 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033102 MIMAT0002876 hsa-miR-505-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002876 hsa-miR-505 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033103 MIMAT0002876 hsa-miR-505-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002876 hsa-miR-505 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033104 MIMAT0002876 hsa-miR-505-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002876 hsa-miR-505 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033105 MIMAT0002876 hsa-miR-505-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002876 hsa-miR-505 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033106 MIMAT0002877 hsa-miR-513a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002877 "hsa-miR-513, hsa-miR-513-5p " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033107 MIMAT0002877 hsa-miR-513a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002877 "hsa-miR-513, hsa-miR-513-5p " miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033108 MIMAT0002877 hsa-miR-513a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002877 "hsa-miR-513, hsa-miR-513-5p " miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033109 MIMAT0002877 hsa-miR-513a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002877 "hsa-miR-513, hsa-miR-513-5p " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033110 MIMAT0002877 hsa-miR-513a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002877 "hsa-miR-513, hsa-miR-513-5p " miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00033111 MIMAT0002877 hsa-miR-513a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002877 "hsa-miR-513, hsa-miR-513-5p " miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray|RT-PCR "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00033112 MIMAT0002878 hsa-miR-506-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002878 hsa-miR-506 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033113 MIMAT0002879 hsa-miR-507 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002879 miRNA Homo sapiens 20145944 Circulating Semen RT-PCR|Microarray "Our results highlight four miRNA markers for blood identification (miR-20a, miR-106a, miR-185, and miR-144) and five for semen identification (miR-135a, miR-10a, miR-507, miR-943, and miR-891a). Of those, two miRNA markers for blood (miR-144 and miR-185) and two others for semen (miR-135a and miR-897a) are suggestive to be most useful for body fluid identification in future forensic applications, and the respective RT-PCR assays used here for their detection were highly sensitive, allowing the reliable marker detection from subpicogram amounts of total RNA. Our results proved the applicability of the miRNA approach for forensic body fluids identification. " RLID00033114 MIMAT0002879 hsa-miR-507 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002879 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033115 MIMAT0002880 hsa-miR-508-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002880 hsa-miR-508 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00033116 MIMAT0002880 hsa-miR-508-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002880 hsa-miR-508 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033117 MIMAT0002881 hsa-miR-509-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002881 hsa-miR-509 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033118 MIMAT0002881 hsa-miR-509-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002881 hsa-miR-509 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00033119 MIMAT0002882 hsa-miR-510-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002882 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033120 MIMAT0002882 hsa-miR-510-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002882 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033121 MIMAT0002883 hsa-miR-514a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002883 hsa-miR-514 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033122 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033123 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033124 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00033125 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033126 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033127 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00033128 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00033129 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033130 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033131 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033132 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033133 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00033134 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00033135 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033136 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033137 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033138 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033139 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033140 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033141 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00033142 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00033143 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033144 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033145 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033146 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033147 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033148 MIMAT0002888 hsa-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002888 hsa-miR-532 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00033149 MIMAT0002889 mmu-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002889 mmu-miR-532 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033150 MIMAT0002889 mmu-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002889 mmu-miR-532 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033151 MIMAT0002889 mmu-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002889 mmu-miR-532 miRNA Mus musculus 23897634 Axon Neuron ball cultures Fluorescence in situ hybridization "We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)].We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)]. Data are collected from Table 1. " RLID00033152 MIMAT0002890 hsa-miR-299-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002890 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033153 MIMAT0002890 hsa-miR-299-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002890 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033154 MIMAT0002890 hsa-miR-299-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002890 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00033155 MIMAT0002890 hsa-miR-299-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002890 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033156 MIMAT0002891 hsa-miR-18a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002891 hsa-miR-18a* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00033157 MIMAT0002891 hsa-miR-18a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002891 hsa-miR-18a* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033158 MIMAT0002891 hsa-miR-18a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002891 hsa-miR-18a* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033159 MIMAT0002891 hsa-miR-18a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002891 hsa-miR-18a* miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00033160 MIMAT0002891 hsa-miR-18a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002891 hsa-miR-18a* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033161 MIMAT0002891 hsa-miR-18a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0002891 hsa-miR-18a* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033162 MIMAT0003112 mmu-miR-489-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003112 mmu-miR-489 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033163 MIMAT0003112 mmu-miR-489-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003112 mmu-miR-489 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033164 MIMAT0003114 rno-miR-383-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003114 rno-miR-383 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00033165 MIMAT0003115 rno-miR-207 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003115 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00033166 MIMAT0003115 rno-miR-207 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003115 miRNA Rattus norvegicus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033167 MIMAT0003117 rno-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003117 rno-miR-361 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00033168 MIMAT0003117 rno-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003117 rno-miR-361 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00033169 MIMAT0003117 rno-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003117 rno-miR-361 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00033170 MIMAT0003119 rno-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003119 rno-miR-224 miRNA Rattus norvegicus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033171 MIMAT0003119 rno-miR-224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003119 rno-miR-224 miRNA Rattus norvegicus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00033172 MIMAT0003125 rno-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003125 rno-miR-1 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00033173 MIMAT0003125 rno-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003125 rno-miR-1 miRNA Rattus norvegicus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033174 MIMAT0003125 rno-miR-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003125 rno-miR-1 miRNA Rattus norvegicus 25092230 Circulating Plasma Microarray "From the above results, miRNAs were selected as candidate plasma miRNA biomarkers as follows: miR-208 (rno-miR- 208a-3p) for cardiotoxicity; miR-1 (rno-miR-1-3p), miR-133a (rno-miR-133a-3p), miR-133a* (rno-miR-133a-5p), and miR-133b (rno-miR-133b-3p) for shared cardiotoxicity and skeletal muscle toxicity; and miR- 206 (rno-miR-206-3p) for skeletal muscle toxicity. " RLID00033175 MIMAT0003126 rno-miR-133b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003126 rno-miR-133b miRNA Rattus norvegicus 25092230 Circulating Plasma Microarray "From the above results, miRNAs were selected as candidate plasma miRNA biomarkers as follows: miR-208 (rno-miR- 208a-3p) for cardiotoxicity; miR-1 (rno-miR-1-3p), miR-133a (rno-miR-133a-3p), miR-133a* (rno-miR-133a-5p), and miR-133b (rno-miR-133b-3p) for shared cardiotoxicity and skeletal muscle toxicity; and miR- 206 (rno-miR-206-3p) for skeletal muscle toxicity. " RLID00033176 MIMAT0003126 rno-miR-133b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003126 rno-miR-133b miRNA Rattus norvegicus 25297646 Circulating Plasma qRT-PCR|Microarray "In plasma, miRNA upregulation was observed for miR-133a and miR-133b following PH and SL, whereas miR-100 and miR-466c were similarly downregulated following anesthesia and surgery. " RLID00033177 MIMAT0003126 rno-miR-133b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003126 rno-miR-133b miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00033178 MIMAT0003127 mmu-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003127 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033179 MIMAT0003127 mmu-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003127 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033180 MIMAT0003127 mmu-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003127 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033181 MIMAT0003127 mmu-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003127 miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00033182 MIMAT0003130 mmu-miR-486a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003130 mmu-miR-486-5p miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033183 MIMAT0003150 hsa-miR-455-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003150 hsa-miR-455 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033184 MIMAT0003150 hsa-miR-455-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003150 hsa-miR-455 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033185 MIMAT0003150 hsa-miR-455-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003150 hsa-miR-455 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033186 MIMAT0003150 hsa-miR-455-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003150 hsa-miR-455 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033187 MIMAT0003150 hsa-miR-455-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003150 hsa-miR-455 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00033188 MIMAT0003150 hsa-miR-455-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003150 hsa-miR-455 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033189 MIMAT0003150 hsa-miR-455-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003150 hsa-miR-455 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033190 MIMAT0003150 hsa-miR-455-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003150 hsa-miR-455 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00033191 MIMAT0003151 mmu-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003151 "mmu-miR-422b, mmu-miR-378, mmu-miR-378-3p " miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00033192 MIMAT0003151 mmu-miR-378a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003151 "mmu-miR-422b, mmu-miR-378, mmu-miR-378-3p " miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00033193 MIMAT0003153 rno-miR-24-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003153 "rno-miR-189, rno-miR-24-1* " miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00033194 MIMAT0003161 hsa-miR-493-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003161 "hsa-miR-493-3p, hsa-miR-493 " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033195 MIMAT0003161 hsa-miR-493-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003161 "hsa-miR-493-3p, hsa-miR-493 " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033196 MIMAT0003161 hsa-miR-493-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003161 "hsa-miR-493-3p, hsa-miR-493 " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033197 MIMAT0003161 hsa-miR-493-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003161 "hsa-miR-493-3p, hsa-miR-493 " miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00033198 MIMAT0003161 hsa-miR-493-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003161 "hsa-miR-493-3p, hsa-miR-493 " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033199 MIMAT0003161 hsa-miR-493-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003161 "hsa-miR-493-3p, hsa-miR-493 " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033200 MIMAT0003163 hsa-miR-539-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003163 hsa-miR-539 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033201 MIMAT0003163 hsa-miR-539-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003163 hsa-miR-539 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033202 MIMAT0003163 hsa-miR-539-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003163 hsa-miR-539 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033203 MIMAT0003164 hsa-miR-544a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003164 hsa-miR-544 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033204 MIMAT0003165 hsa-miR-545-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003165 hsa-miR-545 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033205 MIMAT0003165 hsa-miR-545-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003165 hsa-miR-545 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033206 MIMAT0003165 hsa-miR-545-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003165 hsa-miR-545 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033207 MIMAT0003166 mmu-miR-546 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003166 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00033208 MIMAT0003171 mmu-miR-542-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003171 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00033209 MIMAT0003171 mmu-miR-542-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003171 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033210 MIMAT0003172 mmu-miR-542-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003172 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033211 MIMAT0003172 mmu-miR-542-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003172 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033212 MIMAT0003173 mmu-miR-547-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003173 mmu-miR-547 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033213 MIMAT0003176 rno-miR-539-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003176 rno-miR-539 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00033214 MIMAT0003176 rno-miR-539-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003176 rno-miR-539 miRNA Rattus norvegicus 23682678 Circulating Serum qRT-PCR|Microarray "Generally,there were 25 up-regulated and seven down-regulated miRNAs between serum of ASH and control groups as well as 20 up-regulated and 14 down-regulated miRNAs between liver tissues of ASH and control groups (Table 2). Data are collected from Table 2. " RLID00033215 MIMAT0003177 rno-miR-541-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003177 rno-miR-541 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00033216 MIMAT0003179 rno-miR-542-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003179 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00033217 MIMAT0003179 rno-miR-542-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003179 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00033218 MIMAT0003180 hsa-miR-487b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003180 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033219 MIMAT0003180 hsa-miR-487b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003180 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033220 MIMAT0003180 hsa-miR-487b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003180 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033221 MIMAT0003180 hsa-miR-487b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003180 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033222 MIMAT0003180 hsa-miR-487b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003180 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00033223 MIMAT0003180 hsa-miR-487b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003180 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033224 MIMAT0003180 hsa-miR-487b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003180 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033225 MIMAT0003180 hsa-miR-487b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003180 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00033226 MIMAT0003181 mmu-miR-367-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003181 mmu-miR-367 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033227 MIMAT0003182 mmu-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003182 mmu-miR-494 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00033228 MIMAT0003182 mmu-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003182 mmu-miR-494 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00033229 MIMAT0003183 mmu-miR-376c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003183 mmu-miR-376c miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033230 MIMAT0003187 mmu-miR-20b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003187 mmu-miR-20b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033231 MIMAT0003188 mmu-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003188 mmu-miR-503 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00033232 MIMAT0003188 mmu-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003188 mmu-miR-503 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033233 MIMAT0003188 mmu-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003188 mmu-miR-503 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033234 MIMAT0003189 mmu-miR-291b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003189 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00033235 MIMAT0003192 rno-miR-379-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003192 rno-miR-379 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00033236 MIMAT0003193 rno-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003193 rno-miR-494 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00033237 MIMAT0003193 rno-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003193 rno-miR-494 miRNA Rattus norvegicus 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00033238 MIMAT0003193 rno-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003193 rno-miR-494 miRNA Rattus norvegicus 19106625 Mitochondrion livers qRT-PCR|Microarray "Interestingly, miR-494 appears to be significantly enriched in mitochondria as its abundance in total RNA increased with purification as measured by qRT-PCR. To further define whether the miRNAs were present within the mitochondria, we used deoxycholic acid (DCA) to induce opening of the mitochondrial megapore channel33 and induction of the mitochondria permeability transition (MPT) in the isolated mitochondria.This disruption of mitochondrial integrity resulted in a significant loss of miRNAs by RT-PCR in the DCA treated mitochondria relative to the control vehicle group. The release of miR-130a and b, miR-320 and miR-494 was ~50% and that of miR-140 almost 80%. " RLID00033239 MIMAT0003193 rno-miR-494-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003193 rno-miR-494 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Five miRNAs, miR-340-5p, miR-351, miR-494, miR-664, and let-7e, were significantly concentrated (two- to eightfold) in the nucleolus compared with the nucleoplasm and/or the cytoplasm (Fig. 2A; Supplemental Table 1). " RLID00033240 MIMAT0003196 rno-miR-376b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003196 rno-miR-376b miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00033241 MIMAT0003199 rno-miR-381-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003199 rno-miR-381 miRNA Rattus norvegicus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033242 MIMAT0003200 rno-miR-487b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003200 rno-miR-487b miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00033243 MIMAT0003200 rno-miR-487b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003200 rno-miR-487b miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00033244 MIMAT0003201 rno-miR-382-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003201 rno-miR-382 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00033245 MIMAT0003203 rno-miR-485-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003203 rno-miR-485 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00033246 MIMAT0003203 rno-miR-485-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003203 rno-miR-485 miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00033247 MIMAT0003205 rno-miR-409a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003205 rno-miR-409-3p miRNA Rattus norvegicus 20584895 Axon Sympathetic neurons Microarray "Microarray expression profiling revealed that axons of rat sympathetic neurons contain a large, heterogeneous population of miRNAs (Supplemental Table S1): Several of these miRNAs are highly expressed in these neurons. A listing of miRNAs that are most abundant and/or enriched in the axon is provided in Table 1. Data are collected from Table S1. " RLID00033248 MIMAT0003208 rno-miR-374-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003208 rno-miR-374 miRNA Rattus norvegicus 24553149 Circulating Plasma qRT-PCR|Microarray "Microarray assay results showed a total of 36 differentially-expressed miRNAs, among which 15 miRNAs were considered as aberrantly expressed with a more than 2-fold change when calculating the ratio of fluorescence intense between the 2 groups. The elevated miRNAs included miR-290, miR-874, miR-292-5p, miR-327, miR-374, miR-98, miR-352, miR-132, miR-146b, and miR-196a. The down-regulated miRNAs included miR-145, miR-329, miR-375, miR-140*, and miR-29a. Validation of microarray assay by qRT-PCR showed similar results and the ΔΔCt value compared to the sham group are shown in Figure 1. " RLID00033249 MIMAT0003209 rno-miR-363-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003209 "rno-miR-363-5p, rno-miR-363* " miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00033250 MIMAT0003213 rno-miR-503-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003213 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00033251 MIMAT0003214 hsa-miR-551a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003214 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033252 MIMAT0003217 hsa-miR-554 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003217 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033253 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00033254 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00033255 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033256 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033257 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033258 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00033259 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033260 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033261 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033262 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033263 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00033264 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033265 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033266 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033267 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033268 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033269 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 25420022 Exosome Cerebrospinal fluid Next-generation sequencing Table 1: Reads from next generation sequencing of vesicle RNA isolated from CSF (less than 2 years) and aligned to the human genome. Data are collected from Table 1. RLID00033270 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033271 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033272 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033273 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033274 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00033275 MIMAT0003218 hsa-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003218 hsa-miR-92b miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033276 MIMAT0003219 hsa-miR-555 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003219 miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00033277 MIMAT0003220 hsa-miR-556-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003220 hsa-miR-556 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033278 MIMAT0003221 hsa-miR-557 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003221 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033279 MIMAT0003221 hsa-miR-557 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003221 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033280 MIMAT0003221 hsa-miR-557 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003221 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033281 MIMAT0003221 hsa-miR-557 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003221 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00033282 MIMAT0003221 hsa-miR-557 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003221 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033283 MIMAT0003221 hsa-miR-557 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003221 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033284 MIMAT0003225 hsa-miR-561-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003225 hsa-miR-561 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033285 MIMAT0003227 hsa-miR-563 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003227 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033286 MIMAT0003227 hsa-miR-563 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003227 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00033287 MIMAT0003228 hsa-miR-564 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003228 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033288 MIMAT0003228 hsa-miR-564 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003228 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033289 MIMAT0003228 hsa-miR-564 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003228 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00033290 MIMAT0003228 hsa-miR-564 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003228 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00033291 MIMAT0003228 hsa-miR-564 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003228 miRNA Homo sapiens 20668554 Microvesicle MSC cell qRT-PCR Table 5: Selectively expressed miRNAs from MSC MVs and their cells of origin. Data are collected from Table 5. RLID00033292 MIMAT0003233 hsa-miR-551b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003233 hsa-miR-551b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00033293 MIMAT0003233 hsa-miR-551b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003233 hsa-miR-551b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033294 MIMAT0003233 hsa-miR-551b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003233 hsa-miR-551b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033295 MIMAT0003233 hsa-miR-551b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003233 hsa-miR-551b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033296 MIMAT0003233 hsa-miR-551b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003233 hsa-miR-551b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033297 MIMAT0003236 hsa-miR-571 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003236 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033298 MIMAT0003237 hsa-miR-572 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003237 miRNA Homo sapiens 25126405 Circulating Serum qRT-PCR "Circulating miRNAs in the serum and plasma are remarkably stable and are suggested to have promise as noninvasive biomarkers for neurological and neurodevelopmental disorders. Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated. " RLID00033299 MIMAT0003237 hsa-miR-572 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003237 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033300 MIMAT0003237 hsa-miR-572 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003237 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033301 MIMAT0003238 hsa-miR-573 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003238 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033302 MIMAT0003238 hsa-miR-573 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003238 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00033303 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00033304 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033305 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00033306 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033307 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033308 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033309 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00033310 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00033311 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033312 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00033313 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033314 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033315 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 24373621 Circulating Plasma qRT-PCR "Unsupervised clustering of the expression profiles using the six most regulated miRNAs (miR-425-5p, miR-21-5p, miR-106b-5p, miR-590-5p, miR-574-3p, miR-885-3p) significantly (p = 0.012) separated plasma samples collected prior to treatment from plasma samples collected after two days of radiochemotherapy. " RLID00033316 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00033317 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00033318 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033319 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033320 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033321 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033322 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR "Even under such stringent criteria, 11 miRNAs can be identified as miRNAs that are detectable in the nucleolus with very high levels of confidence (Figure 1D, Table S2). Since the detected nucleolar contents of many of these RNAs are very high, we termed these 11 miRNAs as nucleolar miRNAs. " RLID00033323 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033324 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033325 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033326 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033327 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033328 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033329 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033330 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR|In situ hybridization "Four nucleolar miRNAs; miR191, miR-484, miR-574-3p and miR-193b, were tested in our ISH experiments, and all four miRNAs exhibit strong nucleolar localisation (Figure 2A). " RLID00033331 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033332 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033333 MIMAT0003239 hsa-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003239 hsa-miR-574 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00033334 MIMAT0003240 hsa-miR-575 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003240 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00033335 MIMAT0003240 hsa-miR-575 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003240 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033336 MIMAT0003240 hsa-miR-575 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003240 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033337 MIMAT0003240 hsa-miR-575 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003240 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033338 MIMAT0003240 hsa-miR-575 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003240 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00033339 MIMAT0003241 hsa-miR-576-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003241 hsa-miR-576 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033340 MIMAT0003241 hsa-miR-576-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003241 hsa-miR-576 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033341 MIMAT0003241 hsa-miR-576-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003241 hsa-miR-576 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033342 MIMAT0003241 hsa-miR-576-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003241 hsa-miR-576 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00033343 MIMAT0003241 hsa-miR-576-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003241 hsa-miR-576 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033344 MIMAT0003241 hsa-miR-576-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003241 hsa-miR-576 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033345 MIMAT0003242 hsa-miR-577 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003242 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033346 MIMAT0003242 hsa-miR-577 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003242 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00033347 MIMAT0003243 hsa-miR-578 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003243 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033348 MIMAT0003245 hsa-miR-580-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003245 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033349 MIMAT0003247 hsa-miR-582-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003247 hsa-miR-582 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033350 MIMAT0003247 hsa-miR-582-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003247 hsa-miR-582 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033351 MIMAT0003247 hsa-miR-582-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003247 hsa-miR-582 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033352 MIMAT0003247 hsa-miR-582-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003247 hsa-miR-582 miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00033353 MIMAT0003247 hsa-miR-582-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003247 hsa-miR-582 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033354 MIMAT0003247 hsa-miR-582-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003247 hsa-miR-582 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033355 MIMAT0003247 hsa-miR-582-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003247 hsa-miR-582 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033356 MIMAT0003247 hsa-miR-582-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003247 hsa-miR-582 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033357 MIMAT0003247 hsa-miR-582-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003247 hsa-miR-582 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033358 MIMAT0003247 hsa-miR-582-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003247 hsa-miR-582 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033359 MIMAT0003248 hsa-miR-583 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003248 miRNA Homo sapiens 20145944 Circulating Saliva RT-PCR|Microarray "Also the miRNAs, miR-583, miR-518c*, and miR-208b identified by microarray analysis as candidate markers for saliva and miR-617 for vaginal secretion, demonstrated a strong discordance between microarray and TaqMan data (Electronic supplementary materials, Fig. 2). " RLID00033360 MIMAT0003248 hsa-miR-583 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003248 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033361 MIMAT0003248 hsa-miR-583 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003248 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033362 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033363 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033364 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00033365 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033366 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033367 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00033368 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033369 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033370 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033371 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033372 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033373 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033374 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033375 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00033376 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033377 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033378 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 22529849 Exosome HCC cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033379 MIMAT0003249 hsa-miR-584-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003249 hsa-miR-584 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033380 MIMAT0003250 hsa-miR-585-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003250 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033381 MIMAT0003250 hsa-miR-585-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003250 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00033382 MIMAT0003251 hsa-miR-548a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003251 hsa-miR-548a miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033383 MIMAT0003251 hsa-miR-548a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003251 hsa-miR-548a miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033384 MIMAT0003256 hsa-miR-589-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003256 "hsa-miR-589, hsa-miR-589* " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033385 MIMAT0003256 hsa-miR-589-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003256 "hsa-miR-589, hsa-miR-589* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033386 MIMAT0003256 hsa-miR-589-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003256 "hsa-miR-589, hsa-miR-589* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033387 MIMAT0003257 hsa-miR-550a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003257 "hsa-miR-550, hsa-miR-550*, hsa-miR-550a* " miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033388 MIMAT0003257 hsa-miR-550a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003257 "hsa-miR-550, hsa-miR-550*, hsa-miR-550a* " miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033389 MIMAT0003257 hsa-miR-550a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003257 "hsa-miR-550, hsa-miR-550*, hsa-miR-550a* " miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00033390 MIMAT0003257 hsa-miR-550a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003257 "hsa-miR-550, hsa-miR-550*, hsa-miR-550a* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033391 MIMAT0003257 hsa-miR-550a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003257 "hsa-miR-550, hsa-miR-550*, hsa-miR-550a* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033392 MIMAT0003258 hsa-miR-590-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003258 hsa-miR-590 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033393 MIMAT0003258 hsa-miR-590-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003258 hsa-miR-590 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033394 MIMAT0003258 hsa-miR-590-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003258 hsa-miR-590 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033395 MIMAT0003258 hsa-miR-590-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003258 hsa-miR-590 miRNA Homo sapiens 24373621 Circulating Plasma qRT-PCR "Unsupervised clustering of the expression profiles using the six most regulated miRNAs (miR-425-5p, miR-21-5p, miR-106b-5p, miR-590-5p, miR-574-3p, miR-885-3p) significantly (p = 0.012) separated plasma samples collected prior to treatment from plasma samples collected after two days of radiochemotherapy. " RLID00033396 MIMAT0003258 hsa-miR-590-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003258 hsa-miR-590 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033397 MIMAT0003258 hsa-miR-590-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003258 hsa-miR-590 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00033398 MIMAT0003258 hsa-miR-590-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003258 hsa-miR-590 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033399 MIMAT0003258 hsa-miR-590-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003258 hsa-miR-590 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033400 MIMAT0003258 hsa-miR-590-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003258 hsa-miR-590 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033401 MIMAT0003258 hsa-miR-590-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003258 hsa-miR-590 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033402 MIMAT0003258 hsa-miR-590-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003258 hsa-miR-590 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033403 MIMAT0003258 hsa-miR-590-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003258 hsa-miR-590 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033404 MIMAT0003260 hsa-miR-592 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003260 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033405 MIMAT0003260 hsa-miR-592 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003260 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033406 MIMAT0003261 hsa-miR-593-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003261 "hsa-miR-593, hsa-miR-593* " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033407 MIMAT0003261 hsa-miR-593-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003261 "hsa-miR-593, hsa-miR-593* " miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033408 MIMAT0003263 hsa-miR-595 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003263 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033409 MIMAT0003263 hsa-miR-595 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003263 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033410 MIMAT0003263 hsa-miR-595 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003263 miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00033411 MIMAT0003263 hsa-miR-595 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003263 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033412 MIMAT0003264 hsa-miR-596 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003264 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00033413 MIMAT0003265 hsa-miR-597-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003265 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033414 MIMAT0003266 hsa-miR-598-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003266 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033415 MIMAT0003266 hsa-miR-598-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003266 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 1: Ten miRNAs differentially expressed in both tumor tissue and serum. Data are collected from Table 1. RLID00033416 MIMAT0003266 hsa-miR-598-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003266 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033417 MIMAT0003266 hsa-miR-598-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003266 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033418 MIMAT0003266 hsa-miR-598-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003266 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00033419 MIMAT0003266 hsa-miR-598-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003266 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00033420 MIMAT0003266 hsa-miR-598-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003266 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033421 MIMAT0003266 hsa-miR-598-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003266 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033422 MIMAT0003269 hsa-miR-601 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003269 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033423 MIMAT0003269 hsa-miR-601 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003269 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033424 MIMAT0003269 hsa-miR-601 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003269 miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00033425 MIMAT0003270 hsa-miR-602 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003270 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033426 MIMAT0003270 hsa-miR-602 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003270 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033427 MIMAT0003270 hsa-miR-602 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003270 miRNA Homo sapiens 24468161 Exosome Breast cancer cell RT-PCR|Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00033428 MIMAT0003270 hsa-miR-602 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003270 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In contrast to oncomirs, an miRNA that is involved in tumor-suppressing activities, is taken as a tumor suppressor (oncosuppressor). The aberrantly expressed miR-223, which directly targeted Stathmin 1 to inhibit HCC growth, was only found in MVs of liver cancer cell line in our study (table 2). Data are collected from Table 2. " RLID00033429 MIMAT0003270 hsa-miR-602 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003270 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033430 MIMAT0003271 hsa-miR-603 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003271 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033431 MIMAT0003271 hsa-miR-603 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003271 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033432 MIMAT0003271 hsa-miR-603 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003271 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033433 MIMAT0003271 hsa-miR-603 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003271 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033434 MIMAT0003271 hsa-miR-603 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003271 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033435 MIMAT0003273 hsa-miR-605-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003273 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033436 MIMAT0003276 hsa-miR-608 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003276 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033437 MIMAT0003276 hsa-miR-608 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003276 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033438 MIMAT0003277 hsa-miR-609 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003277 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033439 MIMAT0003278 hsa-miR-610 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003278 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033440 MIMAT0003278 hsa-miR-610 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003278 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033441 MIMAT0003279 hsa-miR-611 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003279 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033442 MIMAT0003280 hsa-miR-612 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003280 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033443 MIMAT0003280 hsa-miR-612 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003280 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00033444 MIMAT0003280 hsa-miR-612 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003280 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00033445 MIMAT0003280 hsa-miR-612 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003280 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033446 MIMAT0003281 hsa-miR-613 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003281 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033447 MIMAT0003282 hsa-miR-614 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003282 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033448 MIMAT0003283 hsa-miR-615-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003283 hsa-miR-615 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033449 MIMAT0003283 hsa-miR-615-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003283 hsa-miR-615 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033450 MIMAT0003283 hsa-miR-615-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003283 hsa-miR-615 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033451 MIMAT0003283 hsa-miR-615-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003283 hsa-miR-615 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033452 MIMAT0003283 hsa-miR-615-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003283 hsa-miR-615 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033453 MIMAT0003284 hsa-miR-616-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003284 "hsa-miR-616, hsa-miR-616* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033454 MIMAT0003286 hsa-miR-617 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003286 miRNA Homo sapiens 20145944 Circulating Vaginal secretion RT-PCR|Microarray "Also the miRNAs, miR-583, miR-518c*, and miR-208b identified by microarray analysis as candidate markers for saliva and miR-617 for vaginal secretion, demonstrated a strong discordance between microarray and TaqMan data (Electronic supplementary materials, Fig. 2). " RLID00033455 MIMAT0003286 hsa-miR-617 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003286 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033456 MIMAT0003286 hsa-miR-617 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003286 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033457 MIMAT0003286 hsa-miR-617 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003286 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033458 MIMAT0003287 hsa-miR-618 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003287 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033459 MIMAT0003287 hsa-miR-618 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003287 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033460 MIMAT0003288 hsa-miR-619-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003288 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033461 MIMAT0003290 hsa-miR-621 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003290 miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00033462 MIMAT0003290 hsa-miR-621 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003290 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033463 MIMAT0003291 hsa-miR-622 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003291 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033464 MIMAT0003292 hsa-miR-623 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003292 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033465 MIMAT0003292 hsa-miR-623 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003292 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033466 MIMAT0003293 hsa-miR-624-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003293 "hsa-miR-624, hsa-miR-624* " miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033467 MIMAT0003293 hsa-miR-624-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003293 "hsa-miR-624, hsa-miR-624* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033468 MIMAT0003293 hsa-miR-624-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003293 "hsa-miR-624, hsa-miR-624* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033469 MIMAT0003294 hsa-miR-625-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003294 hsa-miR-625 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033470 MIMAT0003294 hsa-miR-625-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003294 hsa-miR-625 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033471 MIMAT0003294 hsa-miR-625-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003294 hsa-miR-625 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00033472 MIMAT0003294 hsa-miR-625-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003294 hsa-miR-625 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033473 MIMAT0003294 hsa-miR-625-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003294 hsa-miR-625 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033474 MIMAT0003295 hsa-miR-626 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003295 miRNA Homo sapiens 23938262 Circulating Plasma RT-PCR|Microarray "Plasma-based circulating MicroRNA biomarkers for Parkinson's disease. We identified 9 pairs of PD-predictive classifiers using k-TSP analysis and 13 most differentially-expressed miRNAs by SAM. A combination of both data sets produced a panel of PD-predictive biomarkers: k-TSP1 (miR-1826/miR-450b-3p), miR-626, and miR-505, and achieved the highest predictive power of 91% sensitivity, 100% specificity, 100% positive predicted value, and 88% negative predicted value in the replication set. However, low predictive values were shown in the validation set. " RLID00033475 MIMAT0003295 hsa-miR-626 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003295 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00033476 MIMAT0003296 hsa-miR-627-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003296 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033477 MIMAT0003296 hsa-miR-627-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003296 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033478 MIMAT0003296 hsa-miR-627-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003296 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033479 MIMAT0003297 hsa-miR-628-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003297 hsa-miR-628 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00033480 MIMAT0003297 hsa-miR-628-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003297 hsa-miR-628 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033481 MIMAT0003297 hsa-miR-628-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003297 hsa-miR-628 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033482 MIMAT0003297 hsa-miR-628-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003297 hsa-miR-628 miRNA Homo sapiens 24352417 Circulating Blood platelet Next-generation sequencing "Platelets in both groups demonstrated miRNA expression profiles comparable to previously published data. The statistical analysis unveiled a signature of only three miRNAs (miR-377-5p, miR-628-3p, miR-3137) with high reselection probabilities in resampling techniques. " RLID00033483 MIMAT0003297 hsa-miR-628-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003297 hsa-miR-628 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00033484 MIMAT0003297 hsa-miR-628-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003297 hsa-miR-628 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033485 MIMAT0003297 hsa-miR-628-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003297 hsa-miR-628 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033486 MIMAT0003297 hsa-miR-628-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003297 hsa-miR-628 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033487 MIMAT0003297 hsa-miR-628-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003297 hsa-miR-628 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00033488 MIMAT0003297 hsa-miR-628-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003297 hsa-miR-628 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033489 MIMAT0003298 hsa-miR-629-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003298 "hsa-miR-629, hsa-miR-629* " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033490 MIMAT0003298 hsa-miR-629-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003298 "hsa-miR-629, hsa-miR-629* " miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033491 MIMAT0003298 hsa-miR-629-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003298 "hsa-miR-629, hsa-miR-629* " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00033492 MIMAT0003298 hsa-miR-629-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003298 "hsa-miR-629, hsa-miR-629* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033493 MIMAT0003298 hsa-miR-629-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003298 "hsa-miR-629, hsa-miR-629* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033494 MIMAT0003299 hsa-miR-630 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003299 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033495 MIMAT0003299 hsa-miR-630 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003299 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033496 MIMAT0003299 hsa-miR-630 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003299 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033497 MIMAT0003300 hsa-miR-631 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003300 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033498 MIMAT0003300 hsa-miR-631 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003300 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033499 MIMAT0003301 hsa-miR-33b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003301 hsa-miR-33b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033500 MIMAT0003301 hsa-miR-33b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003301 hsa-miR-33b miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033501 MIMAT0003301 hsa-miR-33b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003301 hsa-miR-33b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033502 MIMAT0003301 hsa-miR-33b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003301 hsa-miR-33b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033503 MIMAT0003301 hsa-miR-33b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003301 hsa-miR-33b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033504 MIMAT0003301 hsa-miR-33b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003301 hsa-miR-33b miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00033505 MIMAT0003302 hsa-miR-632 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003302 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033506 MIMAT0003304 hsa-miR-634 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003304 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033507 MIMAT0003304 hsa-miR-634 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003304 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033508 MIMAT0003304 hsa-miR-634 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003304 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033509 MIMAT0003304 hsa-miR-634 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003304 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033510 MIMAT0003306 hsa-miR-636 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003306 miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00033511 MIMAT0003306 hsa-miR-636 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003306 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033512 MIMAT0003306 hsa-miR-636 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003306 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033513 MIMAT0003306 hsa-miR-636 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003306 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033514 MIMAT0003306 hsa-miR-636 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003306 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033515 MIMAT0003307 hsa-miR-637 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003307 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033516 MIMAT0003307 hsa-miR-637 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003307 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033517 MIMAT0003307 hsa-miR-637 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003307 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033518 MIMAT0003308 hsa-miR-638 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003308 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033519 MIMAT0003308 hsa-miR-638 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003308 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00033520 MIMAT0003308 hsa-miR-638 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003308 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033521 MIMAT0003308 hsa-miR-638 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003308 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033522 MIMAT0003308 hsa-miR-638 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003308 miRNA Homo sapiens 22997154 Circulating Plasma Microarray "Co-transfection with HBV replicative constructs suggested that let-7f, miR-939 and miR-638 can modulate HBV replication. Therefore, we propose that the miRNA profile constitutes a novel circulating marker that can help to predict response to IFN treatment in CHB patients. " RLID00033523 MIMAT0003308 hsa-miR-638 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003308 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033524 MIMAT0003308 hsa-miR-638 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003308 miRNA Homo sapiens 23169280 Circulating Serum Microarray "Table 2 miRNAs detected in pooled patient and control samples, as detected by Agilent Human miRNA microarrays. All of these showed potential as biomarkers as the levels of miRNAs varied between the patient and control groups. The expression levels of six of these miRNAs (in bold) were verified using TaqMan qRT–PCR. Three miRNAs (miR-720, miR-1246 and miR-1308) chosen for further analysis in individual patient samples. TaqMan qRT–PCR assays for the remaining three miRNAs were not available or were unreliable. Data are collected from Table 2. " RLID00033525 MIMAT0003308 hsa-miR-638 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003308 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00033526 MIMAT0003308 hsa-miR-638 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003308 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00033527 MIMAT0003308 hsa-miR-638 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003308 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00033528 MIMAT0003308 hsa-miR-638 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003308 miRNA Homo sapiens 25394686 Exosome Hepatocellular cancer cell qRT-PCR "These data suggest that SMPD3 plays an important role in the release of a number of microRNAs, including miR-638, and that microRNAs accumulated in cells following the inhibition of exosome membrane formation by GW4869. " RLID00033529 MIMAT0003308 hsa-miR-638 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003308 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray|RT-PCR "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00033530 MIMAT0003309 hsa-miR-639 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003309 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033531 MIMAT0003310 hsa-miR-640 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003310 miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00033532 MIMAT0003310 hsa-miR-640 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003310 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033533 MIMAT0003311 hsa-miR-641 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003311 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033534 MIMAT0003311 hsa-miR-641 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003311 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033535 MIMAT0003311 hsa-miR-641 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003311 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033536 MIMAT0003312 hsa-miR-642a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003312 "hsa-miR-642, hsa-miR-642a " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033537 MIMAT0003312 hsa-miR-642a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003312 "hsa-miR-642, hsa-miR-642a " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033538 MIMAT0003312 hsa-miR-642a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003312 "hsa-miR-642, hsa-miR-642a " miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033539 MIMAT0003312 hsa-miR-642a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003312 "hsa-miR-642, hsa-miR-642a " miRNA Homo sapiens 20668554 Microvesicle Liver stem cell qRT-PCR Table 4: Selectively expressed miRNAs from HLSC MVs and their cells of origin. Data are collected from Table 4. RLID00033540 MIMAT0003313 hsa-miR-643 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003313 miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00033541 MIMAT0003313 hsa-miR-643 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003313 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033542 MIMAT0003315 hsa-miR-645 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003315 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033543 MIMAT0003316 hsa-miR-646 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003316 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00033544 MIMAT0003316 hsa-miR-646 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003316 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00033545 MIMAT0003316 hsa-miR-646 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003316 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033546 MIMAT0003316 hsa-miR-646 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003316 miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033547 MIMAT0003316 hsa-miR-646 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003316 miRNA Homo sapiens 22529849 Exosome Liver carcinoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033548 MIMAT0003317 hsa-miR-647 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003317 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033549 MIMAT0003317 hsa-miR-647 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003317 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033550 MIMAT0003318 hsa-miR-648 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003318 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00033551 MIMAT0003318 hsa-miR-648 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003318 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00033552 MIMAT0003319 hsa-miR-649 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003319 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033553 MIMAT0003319 hsa-miR-649 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003319 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033554 MIMAT0003320 hsa-miR-650 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003320 miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033555 MIMAT0003321 hsa-miR-651-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003321 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033556 MIMAT0003321 hsa-miR-651-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003321 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033557 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033558 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033559 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00033560 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00033561 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033562 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00033563 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00033564 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033565 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033566 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033567 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00033568 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033569 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033570 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033571 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00033572 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033573 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033574 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033575 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033576 MIMAT0003322 hsa-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003322 hsa-miR-652 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033577 MIMAT0003324 hsa-miR-661 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003324 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033578 MIMAT0003325 hsa-miR-662 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003325 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033579 MIMAT0003325 hsa-miR-662 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003325 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033580 MIMAT0003326 hsa-miR-663a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003326 hsa-miR-663 miRNA Homo sapiens 25126405 Circulating Serum qRT-PCR "Circulating miRNAs in the serum and plasma are remarkably stable and are suggested to have promise as noninvasive biomarkers for neurological and neurodevelopmental disorders. Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated. " RLID00033581 MIMAT0003326 hsa-miR-663a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003326 hsa-miR-663 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033582 MIMAT0003326 hsa-miR-663a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003326 hsa-miR-663 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00033583 MIMAT0003326 hsa-miR-663a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003326 hsa-miR-663 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033584 MIMAT0003326 hsa-miR-663a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003326 hsa-miR-663 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033585 MIMAT0003326 hsa-miR-663a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003326 hsa-miR-663 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00033586 MIMAT0003326 hsa-miR-663a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003326 hsa-miR-663 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033587 MIMAT0003326 hsa-miR-663a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003326 hsa-miR-663 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033588 MIMAT0003326 hsa-miR-663a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003326 hsa-miR-663 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033589 MIMAT0003326 hsa-miR-663a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003326 hsa-miR-663 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033590 MIMAT0003326 hsa-miR-663a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003326 hsa-miR-663 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033591 MIMAT0003327 hsa-miR-449b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003327 hsa-miR-449b miRNA Homo sapiens 22529849 Exosome Renal carcinomas cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033592 MIMAT0003329 hsa-miR-411-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003329 hsa-miR-411 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033593 MIMAT0003329 hsa-miR-411-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003329 hsa-miR-411 miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00033594 MIMAT0003329 hsa-miR-411-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003329 hsa-miR-411 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033595 MIMAT0003329 hsa-miR-411-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003329 hsa-miR-411 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033596 MIMAT0003329 hsa-miR-411-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003329 hsa-miR-411 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033597 MIMAT0003329 hsa-miR-411-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003329 hsa-miR-411 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033598 MIMAT0003329 hsa-miR-411-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003329 hsa-miR-411 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00033599 MIMAT0003329 hsa-miR-411-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003329 hsa-miR-411 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033600 MIMAT0003329 hsa-miR-411-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003329 hsa-miR-411 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00033601 MIMAT0003330 hsa-miR-654-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003330 hsa-miR-654 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00033602 MIMAT0003330 hsa-miR-654-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003330 hsa-miR-654 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033603 MIMAT0003330 hsa-miR-654-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003330 hsa-miR-654 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033604 MIMAT0003330 hsa-miR-654-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003330 hsa-miR-654 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033605 MIMAT0003330 hsa-miR-654-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003330 hsa-miR-654 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033606 MIMAT0003330 hsa-miR-654-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003330 hsa-miR-654 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00033607 MIMAT0003330 hsa-miR-654-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003330 hsa-miR-654 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033608 MIMAT0003330 hsa-miR-654-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003330 hsa-miR-654 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033609 MIMAT0003330 hsa-miR-654-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003330 hsa-miR-654 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033610 MIMAT0003331 hsa-miR-655-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003331 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033611 MIMAT0003333 hsa-miR-549a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003333 hsa-miR-549 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00033612 MIMAT0003335 hsa-miR-657 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003335 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033613 MIMAT0003336 hsa-miR-658 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003336 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033614 MIMAT0003336 hsa-miR-658 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003336 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033615 MIMAT0003336 hsa-miR-658 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003336 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033616 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033617 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033618 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00033619 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033620 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033621 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033622 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033623 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00033624 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00033625 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033626 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033627 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033628 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033629 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033630 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033631 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033632 MIMAT0003338 hsa-miR-660-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003338 hsa-miR-660 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033633 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033634 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033635 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 24456939 Circulating Gastric juice - "In gastric cancer, several circulating miRNAs have been studied as potential diagnostic biomarkers by evaluating their amount in serum, plasma and gastric juice (Table 2). Data are collected from Table 2. " RLID00033636 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033637 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00033638 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033639 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033640 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00033641 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033642 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033643 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033644 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033645 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033646 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033647 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033648 MIMAT0003339 hsa-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003339 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033649 MIMAT0003340 hsa-miR-542-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003340 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033650 MIMAT0003340 hsa-miR-542-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003340 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033651 MIMAT0003340 hsa-miR-542-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003340 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033652 MIMAT0003340 hsa-miR-542-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003340 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033653 MIMAT0003340 hsa-miR-542-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003340 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033654 MIMAT0003344 sv40-miR-S1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003344 miRNA Simian virus 40 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00033655 MIMAT0003378 rno-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003378 "rno-miR-378, rno-miR-378* " miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00033656 MIMAT0003378 rno-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003378 "rno-miR-378, rno-miR-378* " miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00033657 MIMAT0003378 rno-miR-378a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003378 "rno-miR-378, rno-miR-378* " miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00033658 MIMAT0003382 rno-miR-664-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003382 rno-miR-664 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00033659 MIMAT0003382 rno-miR-664-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003382 rno-miR-664 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Five miRNAs, miR-340-5p, miR-351, miR-494, miR-664, and let-7e, were significantly concentrated (two- to eightfold) in the nucleolus compared with the nucleoplasm and/or the cytoplasm (Fig. 2A; Supplemental Table 1). " RLID00033660 MIMAT0003383 rno-miR-497-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003383 rno-miR-497 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00033661 MIMAT0003385 hsa-miR-363-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003385 hsa-miR-363* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00033662 MIMAT0003385 hsa-miR-363-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003385 hsa-miR-363* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033663 MIMAT0003385 hsa-miR-363-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003385 hsa-miR-363* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033664 MIMAT0003385 hsa-miR-363-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003385 hsa-miR-363* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033665 MIMAT0003386 hsa-miR-376a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003386 hsa-miR-376a* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033666 MIMAT0003386 hsa-miR-376a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003386 hsa-miR-376a* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033667 MIMAT0003389 hsa-miR-542-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003389 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033668 MIMAT0003389 hsa-miR-542-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003389 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033669 MIMAT0003389 hsa-miR-542-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003389 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033670 MIMAT0003389 hsa-miR-542-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003389 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033671 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033672 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033673 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033674 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033675 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033676 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033677 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 24373621 Circulating Plasma qRT-PCR "Unsupervised clustering of the expression profiles using the six most regulated miRNAs (miR-425-5p, miR-21-5p, miR-106b-5p, miR-590-5p, miR-574-3p, miR-885-3p) significantly (p = 0.012) separated plasma samples collected prior to treatment from plasma samples collected after two days of radiochemotherapy. " RLID00033678 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00033679 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033680 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033681 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033682 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033683 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033684 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033685 MIMAT0003393 hsa-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003393 "hsa-miR-425-5p, hsa-miR-425 " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00033686 MIMAT0003409 mmu-miR-467a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003409 "mmu-miR-467*, mmu-miR-467a " miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00033687 MIMAT0003409 mmu-miR-467a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003409 "mmu-miR-467*, mmu-miR-467a " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033688 MIMAT0003450 mmu-miR-488-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003450 "mmu-miR-488*, mmu-miR-488 " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033689 MIMAT0003453 mmu-miR-497a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003453 mmu-miR-497-5p miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033690 MIMAT0003454 mmu-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003454 mmu-miR-423 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033691 MIMAT0003454 mmu-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003454 mmu-miR-423 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033692 MIMAT0003454 mmu-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003454 mmu-miR-423 miRNA Mus musculus 23897634 Cell body Neuron ball cultures Fluorescence in situ hybridization Data are collected from Table 2: Cell Body-Enriched miRNAs. RLID00033693 MIMAT0003455 mmu-miR-679-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003455 mmu-miR-679 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033694 MIMAT0003456 mmu-miR-495-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003456 mmu-miR-495 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033695 MIMAT0003456 mmu-miR-495-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003456 mmu-miR-495 miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00033696 MIMAT0003457 mmu-miR-680 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003457 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033697 MIMAT0003457 mmu-miR-680 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003457 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00033698 MIMAT0003457 mmu-miR-680 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003457 miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00033699 MIMAT0003459 mmu-miR-682 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003459 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033700 MIMAT0003459 mmu-miR-682 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003459 miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00033701 MIMAT0003460 mmu-miR-449c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003460 "mmu-miR-449b, mmu-miR-449c " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033702 MIMAT0003461 mmu-miR-683 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003461 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033703 MIMAT0003469 mmu-miR-690 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003469 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033704 MIMAT0003469 mmu-miR-690 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003469 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00033705 MIMAT0003469 mmu-miR-690 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003469 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00033706 MIMAT0003469 mmu-miR-690 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003469 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033707 MIMAT0003471 mmu-miR-692 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003471 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00033708 MIMAT0003475 mmu-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003475 mmu-miR-146b miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00033709 MIMAT0003475 mmu-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003475 mmu-miR-146b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033710 MIMAT0003475 mmu-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003475 mmu-miR-146b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033711 MIMAT0003478 mmu-miR-467b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003478 "mmu-miR-467b, mmu-miR-467b* " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033712 MIMAT0003479 mmu-miR-669c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003479 mmu-miR-669c miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033713 MIMAT0003483 mmu-miR-696 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003483 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00033714 MIMAT0003485 mmu-miR-455-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003485 "mmu-miR-455, mmu-miR-455-5p, mmu-miR-455* " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033715 MIMAT0003485 mmu-miR-455-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003485 "mmu-miR-455, mmu-miR-455-5p, mmu-miR-455* " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033716 MIMAT0003486 mmu-miR-491-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003486 mmu-miR-491 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033717 MIMAT0003490 mmu-miR-700-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003490 mmu-miR-700 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033718 MIMAT0003493 mmu-miR-703 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003493 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033719 MIMAT0003493 mmu-miR-703 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003493 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00033720 MIMAT0003494 mmu-miR-704 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003494 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033721 MIMAT0003495 mmu-miR-705 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003495 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00033722 MIMAT0003495 mmu-miR-705 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003495 miRNA Mus musculus 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00033723 MIMAT0003495 mmu-miR-705 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003495 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00033724 MIMAT0003496 mmu-miR-706 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003496 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033725 MIMAT0003496 mmu-miR-706 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003496 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033726 MIMAT0003498 mmu-miR-708-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003498 "mmu-miR-708, mmu-miR-708* " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033727 MIMAT0003499 mmu-miR-709 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003499 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033728 MIMAT0003499 mmu-miR-709 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003499 miRNA Mus musculus 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00033729 MIMAT0003499 mmu-miR-709 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003499 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00033730 MIMAT0003499 mmu-miR-709 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003499 miRNA Mus musculus 23897634 Axon Neuron ball cultures Fluorescence in situ hybridization "We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)].We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)]. Data are collected from Table 1. " RLID00033731 MIMAT0003501 mmu-miR-711 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003501 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00033732 MIMAT0003501 mmu-miR-711 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003501 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00033733 MIMAT0003501 mmu-miR-711 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003501 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00033734 MIMAT0003502 mmu-miR-712-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003502 mmu-miR-712 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033735 MIMAT0003502 mmu-miR-712-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003502 mmu-miR-712 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033736 MIMAT0003507 mmu-miR-500-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003507 mmu-miR-500 miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00033737 MIMAT0003507 mmu-miR-500-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003507 mmu-miR-500 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033738 MIMAT0003507 mmu-miR-500-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003507 mmu-miR-500 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033739 MIMAT0003507 mmu-miR-500-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003507 mmu-miR-500 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00033740 MIMAT0003508 mmu-miR-501-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003508 mmu-miR-501 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033741 MIMAT0003509 mmu-miR-501-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003509 mmu-miR-501* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033742 MIMAT0003509 mmu-miR-501-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003509 mmu-miR-501* miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00033743 MIMAT0003512 mmu-miR-450b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003512 mmu-miR-450b* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033744 MIMAT0003515 mmu-miR-721 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003515 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00033745 MIMAT0003515 mmu-miR-721 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003515 miRNA Mus musculus 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00033746 MIMAT0003518 bta-miR-29a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003518 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033747 MIMAT0003522 bta-miR-148a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003522 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033748 MIMAT0003524 bta-miR-151-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003524 bta-miR-151 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033749 MIMAT0003528 bta-miR-21-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003528 bta-miR-21 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033750 MIMAT0003538 bta-miR-125a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003538 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033751 MIMAT0003548 bta-miR-31 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003548 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033752 MIMAT0003711 mmu-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003711 mmu-miR-652 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033753 MIMAT0003711 mmu-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003711 mmu-miR-652 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033754 MIMAT0003711 mmu-miR-652-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003711 mmu-miR-652 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033755 MIMAT0003727 mmu-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003727 "mmu-miR-374-5p, mmu-miR-374, mmu-miR-374-5p " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033756 MIMAT0003730 mmu-miR-592-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003730 mmu-miR-592 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033757 MIMAT0003731 mmu-miR-671-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003731 mmu-miR-671 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00033758 MIMAT0003733 mmu-miR-665-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003733 mmu-miR-665 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033759 MIMAT0003734 mmu-miR-667-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003734 mmu-miR-667 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033760 MIMAT0003735 mmu-miR-672-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003735 mmu-miR-672 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033761 MIMAT0003739 mmu-miR-673-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003739 mmu-miR-673 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033762 MIMAT0003740 mmu-miR-674-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003740 "mmu-miR-674-5p, mmu-miR-674 " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033763 MIMAT0003740 mmu-miR-674-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003740 "mmu-miR-674-5p, mmu-miR-674 " miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033764 MIMAT0003741 mmu-miR-674-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003741 "mmu-miR-674-3p, mmu-miR-674* " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033765 MIMAT0003782 mmu-miR-676-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003782 mmu-miR-676 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033766 MIMAT0003782 mmu-miR-676-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003782 mmu-miR-676 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033767 MIMAT0003782 mmu-miR-676-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003782 mmu-miR-676 miRNA Mus musculus 23897634 Axon Neuron ball cultures Fluorescence in situ hybridization "We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)].We used LNA probes for FISH analyses to validate the localization of the above axon-enriched miRNAs shown to be associated with the RISC in vivo. FISH signals of miR-181a-1* (passenger strand of miR-181a-1) and miR-532, two axon-enriched miRNAs (Table 1), distributed as distinct granules in axons and growth cones as well as cell bodies in cultured cortical neurons [Fig. 3(A)]. Data are collected from Table 1. " RLID00033768 MIMAT0003783 mmu-miR-615-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003783 mmu-miR-615 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033769 MIMAT0003792 bta-miR-15b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003792 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033770 MIMAT0003800 bta-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003800 bta-miR-345 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033771 MIMAT0003810 bta-let-7d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003810 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033772 MIMAT0003815 bta-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003815 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033773 MIMAT0003816 bta-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003816 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033774 MIMAT0003819 bta-miR-191 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003819 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033775 MIMAT0003825 bta-miR-214 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003825 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033776 MIMAT0003827 bta-miR-23a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003827 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033777 MIMAT0003830 bta-miR-361 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003830 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033778 MIMAT0003831 bta-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003831 bta-miR-423 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033779 MIMAT0003841 bta-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003841 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033780 MIMAT0003844 bta-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003844 bta-let-7a miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033781 MIMAT0003879 hsa-miR-758-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003879 hsa-miR-758 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00033782 MIMAT0003879 hsa-miR-758-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003879 hsa-miR-758 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033783 MIMAT0003879 hsa-miR-758-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003879 hsa-miR-758 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033784 MIMAT0003880 hsa-miR-671-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003880 hsa-miR-671 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00033785 MIMAT0003880 hsa-miR-671-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003880 hsa-miR-671 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033786 MIMAT0003880 hsa-miR-671-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003880 hsa-miR-671 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033787 MIMAT0003880 hsa-miR-671-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003880 hsa-miR-671 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033788 MIMAT0003880 hsa-miR-671-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003880 hsa-miR-671 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033789 MIMAT0003880 hsa-miR-671-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003880 hsa-miR-671 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033790 MIMAT0003880 hsa-miR-671-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003880 hsa-miR-671 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033791 MIMAT0003880 hsa-miR-671-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003880 hsa-miR-671 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033792 MIMAT0003880 hsa-miR-671-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003880 hsa-miR-671 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033793 MIMAT0003880 hsa-miR-671-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003880 hsa-miR-671 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033794 MIMAT0003880 hsa-miR-671-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003880 hsa-miR-671 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00033795 MIMAT0003880 hsa-miR-671-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003880 hsa-miR-671 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00033796 MIMAT0003880 hsa-miR-671-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003880 hsa-miR-671 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033797 MIMAT0003881 hsa-miR-668-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003881 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033798 MIMAT0003881 hsa-miR-668-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003881 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033799 MIMAT0003882 hsa-miR-767-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003882 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033800 MIMAT0003882 hsa-miR-767-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003882 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033801 MIMAT0003882 hsa-miR-767-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003882 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033802 MIMAT0003882 hsa-miR-767-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003882 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033803 MIMAT0003882 hsa-miR-767-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003882 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033804 MIMAT0003883 hsa-miR-767-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003883 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033805 MIMAT0003883 hsa-miR-767-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003883 miRNA Homo sapiens 21505438 Exosome Primary dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033806 MIMAT0003883 hsa-miR-767-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003883 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033807 MIMAT0003883 hsa-miR-767-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003883 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033808 MIMAT0003884 hsa-miR-454-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003884 "hsa-miR-454-5p, hsa-miR-454* " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033809 MIMAT0003884 hsa-miR-454-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003884 "hsa-miR-454-5p, hsa-miR-454* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033810 MIMAT0003884 hsa-miR-454-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003884 "hsa-miR-454-5p, hsa-miR-454* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033811 MIMAT0003885 hsa-miR-454-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003885 "hsa-miR-454-3p, hsa-miR-454 " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033812 MIMAT0003885 hsa-miR-454-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003885 "hsa-miR-454-3p, hsa-miR-454 " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033813 MIMAT0003885 hsa-miR-454-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003885 "hsa-miR-454-3p, hsa-miR-454 " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033814 MIMAT0003885 hsa-miR-454-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003885 "hsa-miR-454-3p, hsa-miR-454 " miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00033815 MIMAT0003885 hsa-miR-454-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003885 "hsa-miR-454-3p, hsa-miR-454 " miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00033816 MIMAT0003885 hsa-miR-454-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003885 "hsa-miR-454-3p, hsa-miR-454 " miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033817 MIMAT0003885 hsa-miR-454-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003885 "hsa-miR-454-3p, hsa-miR-454 " miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR "Even under such stringent criteria, 11 miRNAs can be identified as miRNAs that are detectable in the nucleolus with very high levels of confidence (Figure 1D, Table S2). Since the detected nucleolar contents of many of these RNAs are very high, we termed these 11 miRNAs as nucleolar miRNAs. " RLID00033818 MIMAT0003885 hsa-miR-454-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003885 "hsa-miR-454-3p, hsa-miR-454 " miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033819 MIMAT0003885 hsa-miR-454-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003885 "hsa-miR-454-3p, hsa-miR-454 " miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033820 MIMAT0003885 hsa-miR-454-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003885 "hsa-miR-454-3p, hsa-miR-454 " miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033821 MIMAT0003886 hsa-miR-769-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003886 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033822 MIMAT0003886 hsa-miR-769-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003886 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033823 MIMAT0003886 hsa-miR-769-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003886 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033824 MIMAT0003886 hsa-miR-769-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003886 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033825 MIMAT0003886 hsa-miR-769-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003886 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033826 MIMAT0003886 hsa-miR-769-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003886 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033827 MIMAT0003886 hsa-miR-769-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003886 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033828 MIMAT0003886 hsa-miR-769-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003886 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033829 MIMAT0003886 hsa-miR-769-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003886 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033830 MIMAT0003886 hsa-miR-769-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003886 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033831 MIMAT0003886 hsa-miR-769-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003886 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033832 MIMAT0003886 hsa-miR-769-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003886 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00033833 MIMAT0003887 hsa-miR-769-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003887 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033834 MIMAT0003887 hsa-miR-769-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003887 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033835 MIMAT0003887 hsa-miR-769-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003887 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033836 MIMAT0003887 hsa-miR-769-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003887 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033837 MIMAT0003888 hsa-miR-766-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003888 hsa-miR-766 miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00033838 MIMAT0003888 hsa-miR-766-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003888 hsa-miR-766 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033839 MIMAT0003888 hsa-miR-766-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003888 hsa-miR-766 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033840 MIMAT0003888 hsa-miR-766-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003888 hsa-miR-766 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033841 MIMAT0003888 hsa-miR-766-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003888 hsa-miR-766 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033842 MIMAT0003888 hsa-miR-766-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003888 hsa-miR-766 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033843 MIMAT0003888 hsa-miR-766-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003888 hsa-miR-766 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033844 MIMAT0003888 hsa-miR-766-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003888 hsa-miR-766 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033845 MIMAT0003888 hsa-miR-766-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003888 hsa-miR-766 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033846 MIMAT0003888 hsa-miR-766-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003888 hsa-miR-766 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033847 MIMAT0003888 hsa-miR-766-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003888 hsa-miR-766 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033848 MIMAT0003890 mmu-miR-551b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003890 mmu-miR-551b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033849 MIMAT0003892 mmu-miR-762 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003892 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00033850 MIMAT0003892 mmu-miR-762 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003892 miRNA Mus musculus 21862971 Nucleus Liver cell qRT-PCR|Microarray Nuclear miRNA expression profile in C57BL/6J mouse liver as detected by miRNA microarray. Relative expression levels for the 50 miRNAs that exhibited a signal stronger than 2 000 detected on the microarray chip are shown in six columns corresponding to two groups of samples (cells and nuclei). Colors indicate relative signal intensity. The miRNA expression profile was sorted using a hierarchical clustering method (Cluster 3.0 software and Java TreeView). MiR-709 was specifically enriched in the nucleus. Data are collected from Table S1: Liver nucleus miRNA expression profile (top 44) validated via RT-qPCR. RLID00033851 MIMAT0003893 mmu-miR-761 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003893 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00033852 MIMAT0003893 mmu-miR-761 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003893 miRNA Mus musculus 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00033853 MIMAT0003896 mmu-miR-763 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003896 miRNA Mus musculus 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00033854 MIMAT0003945 hsa-miR-765 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003945 miRNA Homo sapiens 20883153 Circulating Plasma qRT-PCR|Microarray "In mild TBI patients (GCS score >=12), miR-765 levels were unchanged, while the plasma levels of miR-92a and miR-16 were significantly increased within the first 24h of injury compared to healthy volunteers, and had AUC values of 0.78 and 0.82, respectively. " RLID00033855 MIMAT0003945 hsa-miR-765 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003945 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00033856 MIMAT0003945 hsa-miR-765 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003945 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033857 MIMAT0003945 hsa-miR-765 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003945 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033858 MIMAT0003945 hsa-miR-765 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003945 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033859 MIMAT0003945 hsa-miR-765 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003945 miRNA Homo sapiens 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00033860 MIMAT0003945 hsa-miR-765 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003945 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00033861 MIMAT0003945 hsa-miR-765 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003945 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00033862 MIMAT0003948 hsa-miR-770-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003948 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033863 MIMAT0003948 hsa-miR-770-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003948 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033864 MIMAT0004089 mdo-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004089 miRNA Monodelphis domestica 25417092 Exosome Serum Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033865 MIMAT0004090 mdo-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004090 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033866 MIMAT0004090 mdo-miR-10b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004090 miRNA Monodelphis domestica 25417092 Exosome Serum Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033867 MIMAT0004092 mdo-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004092 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033868 MIMAT0004092 mdo-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004092 miRNA Monodelphis domestica 25417092 Exosome Serum Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033869 MIMAT0004093 mdo-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004093 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033870 MIMAT0004113 mdo-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004113 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033871 MIMAT0004113 mdo-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004113 miRNA Monodelphis domestica 25417092 Exosome Serum Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033872 MIMAT0004119 mdo-miR-184-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004119 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033873 MIMAT0004127 mdo-miR-204 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004127 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033874 MIMAT0004138 mdo-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004138 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033875 MIMAT0004138 mdo-miR-375 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004138 miRNA Monodelphis domestica 25417092 Exosome Serum Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033876 MIMAT0004141 mdo-let-7a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004141 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033877 MIMAT0004143 mdo-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004143 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033878 MIMAT0004143 mdo-let-7i-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004143 miRNA Monodelphis domestica 25417092 Exosome Serum Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033879 MIMAT0004151 mdo-miR-141-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004151 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033880 MIMAT0004152 mdo-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004152 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033881 MIMAT0004152 mdo-miR-191-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004152 miRNA Monodelphis domestica 25417092 Exosome Serum Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033882 MIMAT0004154 mdo-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004154 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033883 MIMAT0004154 mdo-miR-181a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004154 miRNA Monodelphis domestica 25417092 Exosome Serum Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033884 MIMAT0004161 mdo-let-7f-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004161 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033885 MIMAT0004171 mdo-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004171 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033886 MIMAT0004171 mdo-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004171 miRNA Monodelphis domestica 25417092 Exosome Serum Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033887 MIMAT0004179 mdo-miR-25 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004179 miRNA Monodelphis domestica 25417092 Exosome Serum Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00033888 MIMAT0004186 mmu-miR-301b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004186 mmu-miR-301b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033889 MIMAT0004186 mmu-miR-301b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004186 mmu-miR-301b miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033890 MIMAT0004187 mmu-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004187 mmu-miR-744 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00033891 MIMAT0004187 mmu-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004187 mmu-miR-744 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00033892 MIMAT0004187 mmu-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004187 mmu-miR-744 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00033893 MIMAT0004187 mmu-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004187 mmu-miR-744 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00033894 MIMAT0004238 mmu-miR-743a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004238 "mmu-miR-743, mmu-miR-743a " miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00033895 MIMAT0004284 hsa-miR-675-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004284 hsa-miR-675 miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00033896 MIMAT0004284 hsa-miR-675-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004284 hsa-miR-675 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033897 MIMAT0004284 hsa-miR-675-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004284 hsa-miR-675 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033898 MIMAT0004284 hsa-miR-675-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004284 hsa-miR-675 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00033899 MIMAT0004284 hsa-miR-675-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004284 hsa-miR-675 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033900 MIMAT0004284 hsa-miR-675-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004284 hsa-miR-675 miRNA Homo sapiens 25330373 Microvesicle Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00033901 MIMAT0004284 hsa-miR-675-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004284 hsa-miR-675 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00033902 MIMAT0004324 mmu-miR-181d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004324 mmu-miR-181d miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00033903 MIMAT0004331 bta-let-7b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004331 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033904 MIMAT0004332 bta-let-7c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004332 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033905 MIMAT0004336 bta-miR-19a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004336 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033906 MIMAT0004337 bta-miR-19b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004337 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00033907 MIMAT0004450 hsa-miR-297 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004450 miRNA Homo sapiens 22344312 Circulating Serum Microarray|qRT-PCR "Serum micro-RNAs (miRNAs) can be used for the diagnosis and prognosis of various diseases. Using genome-wide scans, we sought to identify serum miRNAs that could be used as prognostic predictors for sepsis patients. We used microarray screens to identify differentially expressed serum miRNAs by comparing samples from 12 surviving and 12 nonsurviving sepsis patients. These differentially expressed serum miRNAs were validated by quantitative reverse transcriptase-polymerase chain reaction assays for 118 sepsis patients. The validated miRNAs along with sepsis patients' clinical indictors were analyzed in a multivariate logistic regression model. Microarray analysis showed that miR-297 and miR-574-5p were differentially expressed in sepsis survivors and nonsurvivors. Upon validation with 118 sepsis patients' samples, these two miRNA expressions were significantly different, with P < 0.001. miR-297 was more closely associated with survival from sepsis, whereas miR-574-5p was associated with death from sepsis. " RLID00033908 MIMAT0004450 hsa-miR-297 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004450 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00033909 MIMAT0004481 hsa-let-7a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004481 hsa-let-7a* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033910 MIMAT0004481 hsa-let-7a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004481 hsa-let-7a* miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00033911 MIMAT0004481 hsa-let-7a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004481 hsa-let-7a* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033912 MIMAT0004481 hsa-let-7a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004481 hsa-let-7a* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033913 MIMAT0004481 hsa-let-7a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004481 hsa-let-7a* miRNA Homo sapiens 25330373 Extracellular vesicle Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00033914 MIMAT0004482 hsa-let-7b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004482 hsa-let-7b* miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00033915 MIMAT0004482 hsa-let-7b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004482 hsa-let-7b* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033916 MIMAT0004482 hsa-let-7b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004482 hsa-let-7b* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033917 MIMAT0004482 hsa-let-7b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004482 hsa-let-7b* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033918 MIMAT0004482 hsa-let-7b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004482 hsa-let-7b* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033919 MIMAT0004482 hsa-let-7b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004482 hsa-let-7b* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033920 MIMAT0004482 hsa-let-7b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004482 hsa-let-7b* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033921 MIMAT0004482 hsa-let-7b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004482 hsa-let-7b* miRNA Homo sapiens 21637849 Mitochondrion Myoblast In situ hybridization|qRT-PCR "Other members of the let-7 familly, detected by RT-qPCR, had putative targets. These results suggested that some miRNA detected in the mitochondria like let-7 familly (let-7b, c, d, e, f, i) and mir-134a could be involved in a mitochondrial mRNA silencing regulation. " RLID00033922 MIMAT0004484 hsa-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004484 hsa-let-7d* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033923 MIMAT0004484 hsa-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004484 hsa-let-7d* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033924 MIMAT0004484 hsa-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004484 hsa-let-7d* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00033925 MIMAT0004484 hsa-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004484 hsa-let-7d* miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00033926 MIMAT0004484 hsa-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004484 hsa-let-7d* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033927 MIMAT0004484 hsa-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004484 hsa-let-7d* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00033928 MIMAT0004484 hsa-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004484 hsa-let-7d* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033929 MIMAT0004484 hsa-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004484 hsa-let-7d* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033930 MIMAT0004484 hsa-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004484 hsa-let-7d* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033931 MIMAT0004484 hsa-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004484 hsa-let-7d* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033932 MIMAT0004484 hsa-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004484 hsa-let-7d* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033933 MIMAT0004484 hsa-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004484 hsa-let-7d* miRNA Homo sapiens 21637849 Mitochondrion Myoblast In situ hybridization|qRT-PCR "Other members of the let-7 familly, detected by RT-qPCR, had putative targets. These results suggested that some miRNA detected in the mitochondria like let-7 familly (let-7b, c, d, e, f, i) and mir-137a could be involved in a mitochondrial mRNA silencing regulation. " RLID00033934 MIMAT0004484 hsa-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004484 hsa-let-7d* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00033935 MIMAT0004485 hsa-let-7e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004485 hsa-let-7e* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00033936 MIMAT0004485 hsa-let-7e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004485 hsa-let-7e* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00033937 MIMAT0004485 hsa-let-7e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004485 hsa-let-7e* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033938 MIMAT0004485 hsa-let-7e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004485 hsa-let-7e* miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00033939 MIMAT0004486 hsa-let-7f-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004486 hsa-let-7f-1* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033940 MIMAT0004486 hsa-let-7f-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004486 hsa-let-7f-1* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033941 MIMAT0004486 hsa-let-7f-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004486 hsa-let-7f-1* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033942 MIMAT0004486 hsa-let-7f-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004486 hsa-let-7f-1* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033943 MIMAT0004486 hsa-let-7f-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004486 hsa-let-7f-1* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033944 MIMAT0004486 hsa-let-7f-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004486 hsa-let-7f-1* miRNA Homo sapiens 25330373 Extracellular vesicle Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00033945 MIMAT0004487 hsa-let-7f-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004487 hsa-let-7f-2* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033946 MIMAT0004488 hsa-miR-15a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004488 hsa-miR-15a* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033947 MIMAT0004488 hsa-miR-15a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004488 hsa-miR-15a* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00033948 MIMAT0004488 hsa-miR-15a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004488 hsa-miR-15a* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033949 MIMAT0004488 hsa-miR-15a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004488 hsa-miR-15a* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033950 MIMAT0004489 hsa-miR-16-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004489 hsa-miR-16-1* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033951 MIMAT0004490 hsa-miR-19a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004490 hsa-miR-19a* miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00033952 MIMAT0004491 hsa-miR-19b-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004491 hsa-miR-19b-1* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033953 MIMAT0004491 hsa-miR-19b-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004491 hsa-miR-19b-1* miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00033954 MIMAT0004491 hsa-miR-19b-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004491 hsa-miR-19b-1* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033955 MIMAT0004491 hsa-miR-19b-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004491 hsa-miR-19b-1* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033956 MIMAT0004491 hsa-miR-19b-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004491 hsa-miR-19b-1* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033957 MIMAT0004492 hsa-miR-19b-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004492 hsa-miR-19b-2* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033958 MIMAT0004493 hsa-miR-20a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004493 hsa-miR-20a* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033959 MIMAT0004493 hsa-miR-20a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004493 hsa-miR-20a* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00033960 MIMAT0004494 hsa-miR-21-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004494 hsa-miR-21* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033961 MIMAT0004494 hsa-miR-21-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004494 hsa-miR-21* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033962 MIMAT0004494 hsa-miR-21-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004494 hsa-miR-21* miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033963 MIMAT0004494 hsa-miR-21-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004494 hsa-miR-21* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033964 MIMAT0004494 hsa-miR-21-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004494 hsa-miR-21* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00033965 MIMAT0004494 hsa-miR-21-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004494 hsa-miR-21* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033966 MIMAT0004494 hsa-miR-21-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004494 hsa-miR-21* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033967 MIMAT0004494 hsa-miR-21-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004494 hsa-miR-21* miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00033968 MIMAT0004494 hsa-miR-21-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004494 hsa-miR-21* miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00033969 MIMAT0004495 hsa-miR-22-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004495 hsa-miR-22* miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00033970 MIMAT0004495 hsa-miR-22-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004495 hsa-miR-22* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033971 MIMAT0004495 hsa-miR-22-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004495 hsa-miR-22* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033972 MIMAT0004495 hsa-miR-22-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004495 hsa-miR-22* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033973 MIMAT0004495 hsa-miR-22-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004495 hsa-miR-22* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033974 MIMAT0004495 hsa-miR-22-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004495 hsa-miR-22* miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00033975 MIMAT0004495 hsa-miR-22-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004495 hsa-miR-22* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00033976 MIMAT0004496 hsa-miR-23a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004496 hsa-miR-23a* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00033977 MIMAT0004496 hsa-miR-23a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004496 hsa-miR-23a* miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00033978 MIMAT0004496 hsa-miR-23a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004496 hsa-miR-23a* miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00033979 MIMAT0004496 hsa-miR-23a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004496 hsa-miR-23a* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00033980 MIMAT0004497 hsa-miR-24-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004497 hsa-miR-24-2* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033981 MIMAT0004497 hsa-miR-24-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004497 hsa-miR-24-2* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033982 MIMAT0004497 hsa-miR-24-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004497 hsa-miR-24-2* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033983 MIMAT0004497 hsa-miR-24-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004497 hsa-miR-24-2* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033984 MIMAT0004498 hsa-miR-25-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004498 hsa-miR-25* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00033985 MIMAT0004498 hsa-miR-25-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004498 hsa-miR-25* miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00033986 MIMAT0004498 hsa-miR-25-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004498 hsa-miR-25* miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033987 MIMAT0004498 hsa-miR-25-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004498 hsa-miR-25* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033988 MIMAT0004498 hsa-miR-25-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004498 hsa-miR-25* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00033989 MIMAT0004498 hsa-miR-25-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004498 hsa-miR-25* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00033990 MIMAT0004499 hsa-miR-26a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004499 hsa-miR-26a-1* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033991 MIMAT0004499 hsa-miR-26a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004499 hsa-miR-26a-1* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00033992 MIMAT0004499 hsa-miR-26a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004499 hsa-miR-26a-1* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00033993 MIMAT0004499 hsa-miR-26a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004499 hsa-miR-26a-1* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033994 MIMAT0004499 hsa-miR-26a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004499 hsa-miR-26a-1* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00033995 MIMAT0004500 hsa-miR-26b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004500 hsa-miR-26b* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00033996 MIMAT0004500 hsa-miR-26b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004500 hsa-miR-26b* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00033997 MIMAT0004500 hsa-miR-26b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004500 hsa-miR-26b* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00033998 MIMAT0004500 hsa-miR-26b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004500 hsa-miR-26b* miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00033999 MIMAT0004500 hsa-miR-26b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004500 hsa-miR-26b* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034000 MIMAT0004500 hsa-miR-26b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004500 hsa-miR-26b* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034001 MIMAT0004500 hsa-miR-26b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004500 hsa-miR-26b* miRNA Homo sapiens 24577456 Circulating Serum Next-generation sequencing The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. Table 2 has displayed the data. RLID00034002 MIMAT0004501 hsa-miR-27a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004501 hsa-miR-27a* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034003 MIMAT0004501 hsa-miR-27a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004501 hsa-miR-27a* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034004 MIMAT0004501 hsa-miR-27a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004501 hsa-miR-27a* miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00034005 MIMAT0004501 hsa-miR-27a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004501 hsa-miR-27a* miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00034006 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034007 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034008 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034009 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034010 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034011 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00034012 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034013 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034014 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034015 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034016 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034017 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034018 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034019 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00034020 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034021 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034022 MIMAT0004502 hsa-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004502 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00034023 MIMAT0004503 hsa-miR-29a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004503 hsa-miR-29a* miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00034024 MIMAT0004503 hsa-miR-29a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004503 hsa-miR-29a* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034025 MIMAT0004504 hsa-miR-31-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004504 hsa-miR-31* miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034026 MIMAT0004505 hsa-miR-32-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004505 hsa-miR-32* miRNA Homo sapiens 21505438 Exosome Primary dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034027 MIMAT0004505 hsa-miR-32-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004505 hsa-miR-32* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034028 MIMAT0004506 hsa-miR-33a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004506 hsa-miR-33a* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034029 MIMAT0004506 hsa-miR-33a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004506 hsa-miR-33a* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034030 MIMAT0004507 hsa-miR-92a-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004507 hsa-miR-92a-1* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034031 MIMAT0004507 hsa-miR-92a-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004507 hsa-miR-92a-1* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034032 MIMAT0004507 hsa-miR-92a-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004507 hsa-miR-92a-1* miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00034033 MIMAT0004507 hsa-miR-92a-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004507 hsa-miR-92a-1* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034034 MIMAT0004507 hsa-miR-92a-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004507 hsa-miR-92a-1* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034035 MIMAT0004507 hsa-miR-92a-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004507 hsa-miR-92a-1* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034036 MIMAT0004507 hsa-miR-92a-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004507 hsa-miR-92a-1* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034037 MIMAT0004507 hsa-miR-92a-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004507 hsa-miR-92a-1* miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00034038 MIMAT0004507 hsa-miR-92a-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004507 hsa-miR-92a-1* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034039 MIMAT0004508 hsa-miR-92a-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004508 hsa-miR-92a-2* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034040 MIMAT0004508 hsa-miR-92a-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004508 hsa-miR-92a-2* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034041 MIMAT0004508 hsa-miR-92a-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004508 hsa-miR-92a-2* miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00034042 MIMAT0004509 hsa-miR-93-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004509 hsa-miR-93* miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034043 MIMAT0004509 hsa-miR-93-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004509 hsa-miR-93* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034044 MIMAT0004509 hsa-miR-93-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004509 hsa-miR-93* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034045 MIMAT0004509 hsa-miR-93-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004509 hsa-miR-93* miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034046 MIMAT0004509 hsa-miR-93-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004509 hsa-miR-93* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034047 MIMAT0004509 hsa-miR-93-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004509 hsa-miR-93* miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR "Even under such stringent criteria, 11 miRNAs can be identified as miRNAs that are detectable in the nucleolus with very high levels of confidence (Figure 1D, Table S2). Since the detected nucleolar contents of many of these RNAs are very high, we termed these 11 miRNAs as nucleolar miRNAs. " RLID00034048 MIMAT0004509 hsa-miR-93-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004509 hsa-miR-93* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034049 MIMAT0004509 hsa-miR-93-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004509 hsa-miR-93* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034050 MIMAT0004509 hsa-miR-93-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004509 hsa-miR-93* miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00034051 MIMAT0004509 hsa-miR-93-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004509 hsa-miR-93* miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00034052 MIMAT0004510 hsa-miR-96-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004510 hsa-miR-96* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034053 MIMAT0004511 hsa-miR-99a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004511 hsa-miR-99a* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034054 MIMAT0004511 hsa-miR-99a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004511 hsa-miR-99a* miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034055 MIMAT0004511 hsa-miR-99a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004511 hsa-miR-99a* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034056 MIMAT0004511 hsa-miR-99a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004511 hsa-miR-99a* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034057 MIMAT0004512 hsa-miR-100-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004512 hsa-miR-100* miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00034058 MIMAT0004513 hsa-miR-101-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004513 hsa-miR-101* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034059 MIMAT0004513 hsa-miR-101-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004513 hsa-miR-101* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034060 MIMAT0004513 hsa-miR-101-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004513 hsa-miR-101* miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In contrast to oncomirs, an miRNA that is involved in tumor-suppressing activities, is taken as a tumor suppressor (oncosuppressor). The aberrantly expressed miR-223, which directly targeted Stathmin 1 to inhibit HCC growth, was only found in MVs of liver cancer cell line in our study (table 2). Data are collected from Table 2. " RLID00034061 MIMAT0004513 hsa-miR-101-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004513 hsa-miR-101* miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00034062 MIMAT0004514 hsa-miR-29b-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004514 hsa-miR-29b-1* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034063 MIMAT0004514 hsa-miR-29b-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004514 hsa-miR-29b-1* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034064 MIMAT0004515 hsa-miR-29b-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004515 hsa-miR-29b-2* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034065 MIMAT0004515 hsa-miR-29b-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004515 hsa-miR-29b-2* miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00034066 MIMAT0004515 hsa-miR-29b-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004515 hsa-miR-29b-2* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034067 MIMAT0004515 hsa-miR-29b-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004515 hsa-miR-29b-2* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034068 MIMAT0004515 hsa-miR-29b-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004515 hsa-miR-29b-2* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034069 MIMAT0004516 hsa-miR-105-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004516 hsa-miR-105* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034070 MIMAT0004516 hsa-miR-105-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004516 hsa-miR-105* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034071 MIMAT0004517 hsa-miR-106a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004517 hsa-miR-106a* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034072 MIMAT0004517 hsa-miR-106a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004517 hsa-miR-106a* miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00034073 MIMAT0004518 hsa-miR-16-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004518 hsa-miR-16-2* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034074 MIMAT0004518 hsa-miR-16-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004518 hsa-miR-16-2* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034075 MIMAT0004518 hsa-miR-16-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004518 hsa-miR-16-2* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034076 MIMAT0004518 hsa-miR-16-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004518 hsa-miR-16-2* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034077 MIMAT0004518 hsa-miR-16-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004518 hsa-miR-16-2* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034078 MIMAT0004518 hsa-miR-16-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004518 hsa-miR-16-2* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034079 MIMAT0004518 hsa-miR-16-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004518 hsa-miR-16-2* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034080 MIMAT0004518 hsa-miR-16-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004518 hsa-miR-16-2* miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00034081 MIMAT0004521 mmu-miR-15b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004521 mmu-miR-15b* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034082 MIMAT0004523 mmu-miR-29b-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004523 "mmu-miR-29b*, mmu-miR-29b-1* " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034083 MIMAT0004528 mmu-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004528 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034084 MIMAT0004528 mmu-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004528 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034085 MIMAT0004536 mmu-miR-151-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004536 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034086 MIMAT0004542 mmu-miR-191-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004542 mmu-miR-191* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034087 MIMAT0004543 hsa-miR-192-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004543 hsa-miR-192* miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00034088 MIMAT0004544 mmu-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004544 "mmu-miR-193*, mmu-miR-193-5p " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034089 MIMAT0004544 mmu-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004544 "mmu-miR-193*, mmu-miR-193-5p " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034090 MIMAT0004546 mmu-miR-202-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004546 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00034091 MIMAT0004548 hsa-miR-129-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004548 hsa-miR-129* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034092 MIMAT0004548 hsa-miR-129-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004548 hsa-miR-129* miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034093 MIMAT0004548 hsa-miR-129-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004548 hsa-miR-129* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034094 MIMAT0004549 hsa-miR-148a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004549 hsa-miR-148a* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034095 MIMAT0004549 hsa-miR-148a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004549 hsa-miR-148a* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034096 MIMAT0004549 hsa-miR-148a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004549 hsa-miR-148a* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034097 MIMAT0004549 hsa-miR-148a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004549 hsa-miR-148a* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034098 MIMAT0004549 hsa-miR-148a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004549 hsa-miR-148a* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034099 MIMAT0004549 hsa-miR-148a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004549 hsa-miR-148a* miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00034100 MIMAT0004549 hsa-miR-148a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004549 hsa-miR-148a* miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00034101 MIMAT0004549 hsa-miR-148a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004549 hsa-miR-148a* miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00034102 MIMAT0004550 hsa-miR-30c-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004550 hsa-miR-30c-2* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034103 MIMAT0004550 hsa-miR-30c-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004550 hsa-miR-30c-2* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034104 MIMAT0004550 hsa-miR-30c-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004550 hsa-miR-30c-2* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034105 MIMAT0004550 hsa-miR-30c-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004550 hsa-miR-30c-2* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034106 MIMAT0004550 hsa-miR-30c-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004550 hsa-miR-30c-2* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034107 MIMAT0004550 hsa-miR-30c-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004550 hsa-miR-30c-2* miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00034108 MIMAT0004550 hsa-miR-30c-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004550 hsa-miR-30c-2* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034109 MIMAT0004551 hsa-miR-30d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004551 hsa-miR-30d* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034110 MIMAT0004551 hsa-miR-30d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004551 hsa-miR-30d* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034111 MIMAT0004551 hsa-miR-30d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004551 hsa-miR-30d* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034112 MIMAT0004551 hsa-miR-30d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004551 hsa-miR-30d* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034113 MIMAT0004552 hsa-miR-139-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004552 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034114 MIMAT0004552 hsa-miR-139-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004552 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034115 MIMAT0004552 hsa-miR-139-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004552 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034116 MIMAT0004552 hsa-miR-139-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004552 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034117 MIMAT0004552 hsa-miR-139-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004552 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034118 MIMAT0004552 hsa-miR-139-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004552 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034119 MIMAT0004552 hsa-miR-139-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004552 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034120 MIMAT0004553 hsa-miR-7-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004553 hsa-miR-7-1* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034121 MIMAT0004553 hsa-miR-7-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004553 hsa-miR-7-1* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034122 MIMAT0004553 hsa-miR-7-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004553 hsa-miR-7-1* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034123 MIMAT0004553 hsa-miR-7-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004553 hsa-miR-7-1* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034124 MIMAT0004553 hsa-miR-7-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004553 hsa-miR-7-1* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034125 MIMAT0004554 hsa-miR-7-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004554 hsa-miR-7-2* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034126 MIMAT0004555 hsa-miR-10a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004555 hsa-miR-10a* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034127 MIMAT0004555 hsa-miR-10a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004555 hsa-miR-10a* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034128 MIMAT0004555 hsa-miR-10a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004555 hsa-miR-10a* miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00034129 MIMAT0004555 hsa-miR-10a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004555 hsa-miR-10a* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034130 MIMAT0004555 hsa-miR-10a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004555 hsa-miR-10a* miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00034131 MIMAT0004556 hsa-miR-10b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004556 hsa-miR-10b* miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034132 MIMAT0004556 hsa-miR-10b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004556 hsa-miR-10b* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034133 MIMAT0004556 hsa-miR-10b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004556 hsa-miR-10b* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034134 MIMAT0004556 hsa-miR-10b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004556 hsa-miR-10b* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034135 MIMAT0004556 hsa-miR-10b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004556 hsa-miR-10b* miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034136 MIMAT0004556 hsa-miR-10b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004556 hsa-miR-10b* miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00034137 MIMAT0004556 hsa-miR-10b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004556 hsa-miR-10b* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034138 MIMAT0004557 hsa-miR-34a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004557 hsa-miR-34a* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034139 MIMAT0004558 hsa-miR-181a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004558 hsa-miR-181a-2* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034140 MIMAT0004558 hsa-miR-181a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004558 hsa-miR-181a-2* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034141 MIMAT0004558 hsa-miR-181a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004558 hsa-miR-181a-2* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034142 MIMAT0004558 hsa-miR-181a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004558 hsa-miR-181a-2* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034143 MIMAT0004558 hsa-miR-181a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004558 hsa-miR-181a-2* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034144 MIMAT0004558 hsa-miR-181a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004558 hsa-miR-181a-2* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034145 MIMAT0004558 hsa-miR-181a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004558 hsa-miR-181a-2* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034146 MIMAT0004558 hsa-miR-181a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004558 hsa-miR-181a-2* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034147 MIMAT0004559 hsa-miR-181c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004559 hsa-miR-181c* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034148 MIMAT0004559 hsa-miR-181c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004559 hsa-miR-181c* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034149 MIMAT0004559 hsa-miR-181c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004559 hsa-miR-181c* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034150 MIMAT0004559 hsa-miR-181c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004559 hsa-miR-181c* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034151 MIMAT0004559 hsa-miR-181c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004559 hsa-miR-181c* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034152 MIMAT0004559 hsa-miR-181c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004559 hsa-miR-181c* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034153 MIMAT0004559 hsa-miR-181c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004559 hsa-miR-181c* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034154 MIMAT0004559 hsa-miR-181c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004559 hsa-miR-181c* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034155 MIMAT0004560 hsa-miR-183-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004560 hsa-miR-183* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034156 MIMAT0004560 hsa-miR-183-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004560 hsa-miR-183* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034157 MIMAT0004560 hsa-miR-183-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004560 hsa-miR-183* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034158 MIMAT0004560 hsa-miR-183-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004560 hsa-miR-183* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034159 MIMAT0004561 hsa-miR-187-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004561 hsa-miR-187* miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00034160 MIMAT0004561 hsa-miR-187-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004561 hsa-miR-187* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034161 MIMAT0004561 hsa-miR-187-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004561 hsa-miR-187* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034162 MIMAT0004562 hsa-miR-196a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004562 hsa-miR-196a* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034163 MIMAT0004563 hsa-miR-199b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004563 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034164 MIMAT0004563 hsa-miR-199b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004563 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034165 MIMAT0004563 hsa-miR-199b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004563 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034166 MIMAT0004563 hsa-miR-199b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004563 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034167 MIMAT0004563 hsa-miR-199b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004563 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00034168 MIMAT0004563 hsa-miR-199b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004563 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034169 MIMAT0004563 hsa-miR-199b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004563 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00034170 MIMAT0004563 hsa-miR-199b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004563 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034171 MIMAT0004563 hsa-miR-199b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004563 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034172 MIMAT0004563 hsa-miR-199b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004563 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034173 MIMAT0004564 hsa-miR-214-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004564 hsa-miR-214* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034174 MIMAT0004564 hsa-miR-214-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004564 hsa-miR-214* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034175 MIMAT0004566 hsa-miR-218-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004566 hsa-miR-218-2* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034176 MIMAT0004567 hsa-miR-219a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004567 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034177 MIMAT0004567 hsa-miR-219a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004567 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034178 MIMAT0004568 hsa-miR-221-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004568 hsa-miR-221* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034179 MIMAT0004568 hsa-miR-221-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004568 hsa-miR-221* miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034180 MIMAT0004568 hsa-miR-221-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004568 hsa-miR-221* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034181 MIMAT0004568 hsa-miR-221-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004568 hsa-miR-221* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034182 MIMAT0004568 hsa-miR-221-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004568 hsa-miR-221* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034183 MIMAT0004568 hsa-miR-221-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004568 hsa-miR-221* miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00034184 MIMAT0004570 hsa-miR-223-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004570 hsa-miR-223* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034185 MIMAT0004570 hsa-miR-223-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004570 hsa-miR-223* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034186 MIMAT0004570 hsa-miR-223-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004570 hsa-miR-223* miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034187 MIMAT0004570 hsa-miR-223-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004570 hsa-miR-223* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034188 MIMAT0004570 hsa-miR-223-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004570 hsa-miR-223* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034189 MIMAT0004570 hsa-miR-223-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004570 hsa-miR-223* miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00034190 MIMAT0004570 hsa-miR-223-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004570 hsa-miR-223* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034191 MIMAT0004570 hsa-miR-223-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004570 hsa-miR-223* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034192 MIMAT0004571 hsa-miR-200b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004571 hsa-miR-200b* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034193 MIMAT0004571 hsa-miR-200b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004571 hsa-miR-200b* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034194 MIMAT0004576 mmu-miR-296-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004576 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034195 MIMAT0004576 mmu-miR-296-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004576 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00034196 MIMAT0004580 mmu-miR-34c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004580 mmu-miR-34c* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034197 MIMAT0004581 mmu-miR-34b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004581 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034198 MIMAT0004582 mmu-miR-106b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004582 mmu-miR-106b* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034199 MIMAT0004582 mmu-miR-106b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004582 mmu-miR-106b* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034200 MIMAT0004583 mmu-miR-130b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004583 mmu-miR-130b* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034201 MIMAT0004583 mmu-miR-130b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004583 mmu-miR-130b* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034202 MIMAT0004584 hsa-let-7g-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004584 hsa-let-7g* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034203 MIMAT0004584 hsa-let-7g-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004584 hsa-let-7g* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00034204 MIMAT0004584 hsa-let-7g-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004584 hsa-let-7g* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034205 MIMAT0004584 hsa-let-7g-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004584 hsa-let-7g* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034206 MIMAT0004584 hsa-let-7g-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004584 hsa-let-7g* miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00034207 MIMAT0004585 hsa-let-7i-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004585 hsa-let-7i* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034208 MIMAT0004585 hsa-let-7i-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004585 hsa-let-7i* miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034209 MIMAT0004585 hsa-let-7i-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004585 hsa-let-7i* miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00034210 MIMAT0004585 hsa-let-7i-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004585 hsa-let-7i* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034211 MIMAT0004585 hsa-let-7i-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004585 hsa-let-7i* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034212 MIMAT0004585 hsa-let-7i-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004585 hsa-let-7i* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034213 MIMAT0004585 hsa-let-7i-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004585 hsa-let-7i* miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00034214 MIMAT0004585 hsa-let-7i-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004585 hsa-let-7i* miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00034215 MIMAT0004585 hsa-let-7i-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004585 hsa-let-7i* miRNA Homo sapiens 21637849 Mitochondrion Myoblast In situ hybridization|qRT-PCR "Other members of the let-7 familly, detected by RT-qPCR, had putative targets. These results suggested that some miRNA detected in the mitochondria like let-7 familly (let-7b, c, d, e, f, i) and mir-142a could be involved in a mitochondrial mRNA silencing regulation. " RLID00034216 MIMAT0004586 hsa-miR-15b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004586 hsa-miR-15b* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034217 MIMAT0004586 hsa-miR-15b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004586 hsa-miR-15b* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034218 MIMAT0004586 hsa-miR-15b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004586 hsa-miR-15b* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034219 MIMAT0004586 hsa-miR-15b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004586 hsa-miR-15b* miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00034220 MIMAT0004586 hsa-miR-15b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004586 hsa-miR-15b* miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00034221 MIMAT0004586 hsa-miR-15b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004586 hsa-miR-15b* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034222 MIMAT0004586 hsa-miR-15b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004586 hsa-miR-15b* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034223 MIMAT0004586 hsa-miR-15b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004586 hsa-miR-15b* miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00034224 MIMAT0004587 hsa-miR-23b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004587 hsa-miR-23b* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034225 MIMAT0004587 hsa-miR-23b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004587 hsa-miR-23b* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034226 MIMAT0004587 hsa-miR-23b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004587 hsa-miR-23b* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034227 MIMAT0004587 hsa-miR-23b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004587 hsa-miR-23b* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034228 MIMAT0004587 hsa-miR-23b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004587 hsa-miR-23b* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034229 MIMAT0004587 hsa-miR-23b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004587 hsa-miR-23b* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034230 MIMAT0004588 hsa-miR-27b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004588 hsa-miR-27b* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034231 MIMAT0004588 hsa-miR-27b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004588 hsa-miR-27b* miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00034232 MIMAT0004588 hsa-miR-27b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004588 hsa-miR-27b* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034233 MIMAT0004588 hsa-miR-27b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004588 hsa-miR-27b* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034234 MIMAT0004588 hsa-miR-27b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004588 hsa-miR-27b* miRNA Homo sapiens 19002258 Microvesicle Plasma qRT-PCR The filtered and normalized data were subjected to hierarchical cluster analysis comparing the miRNA expression profile between the PBMC and plasma microvesicles samples (Figure 3). Data are collectedf from figure 3: miRNA expression from peripheral blood microvesicles and PBMC. RLID00034235 MIMAT0004588 hsa-miR-27b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004588 hsa-miR-27b* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034236 MIMAT0004589 hsa-miR-30b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004589 hsa-miR-30b* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034237 MIMAT0004589 hsa-miR-30b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004589 hsa-miR-30b* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034238 MIMAT0004589 hsa-miR-30b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004589 hsa-miR-30b* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034239 MIMAT0004589 hsa-miR-30b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004589 hsa-miR-30b* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00034240 MIMAT0004589 hsa-miR-30b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004589 hsa-miR-30b* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034241 MIMAT0004590 hsa-miR-122-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004590 hsa-miR-122* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034242 MIMAT0004590 hsa-miR-122-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004590 hsa-miR-122* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034243 MIMAT0004591 hsa-miR-124-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004591 hsa-miR-124* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034244 MIMAT0004591 hsa-miR-124-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004591 hsa-miR-124* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034245 MIMAT0004591 hsa-miR-124-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004591 hsa-miR-124* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034246 MIMAT0004592 hsa-miR-125b-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004592 hsa-miR-125b-1* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034247 MIMAT0004592 hsa-miR-125b-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004592 hsa-miR-125b-1* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034248 MIMAT0004592 hsa-miR-125b-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004592 hsa-miR-125b-1* miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 1: Ten miRNAs differentially expressed in both tumor tissue and serum. Data are collected from Table 1. RLID00034249 MIMAT0004592 hsa-miR-125b-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004592 hsa-miR-125b-1* miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00034250 MIMAT0004592 hsa-miR-125b-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004592 hsa-miR-125b-1* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034251 MIMAT0004592 hsa-miR-125b-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004592 hsa-miR-125b-1* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034252 MIMAT0004592 hsa-miR-125b-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004592 hsa-miR-125b-1* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034253 MIMAT0004592 hsa-miR-125b-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004592 hsa-miR-125b-1* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034254 MIMAT0004592 hsa-miR-125b-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004592 hsa-miR-125b-1* miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00034255 MIMAT0004592 hsa-miR-125b-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004592 hsa-miR-125b-1* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034256 MIMAT0004593 hsa-miR-130a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004593 hsa-miR-130a* miRNA Homo sapiens 24468161 Exosome Breast cancer cell RT-PCR|Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00034257 MIMAT0004593 hsa-miR-130a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004593 hsa-miR-130a* miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00034258 MIMAT0004594 hsa-miR-132-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004594 hsa-miR-132* miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 1: Ten miRNAs differentially expressed in both tumor tissue and serum. Data are collected from Table 1. RLID00034259 MIMAT0004594 hsa-miR-132-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004594 hsa-miR-132* miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034260 MIMAT0004594 hsa-miR-132-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004594 hsa-miR-132* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034261 MIMAT0004594 hsa-miR-132-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004594 hsa-miR-132* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034262 MIMAT0004594 hsa-miR-132-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004594 hsa-miR-132* miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00034263 MIMAT0004595 hsa-miR-135a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004595 hsa-miR-135a* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034264 MIMAT0004595 hsa-miR-135a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004595 hsa-miR-135a* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034265 MIMAT0004595 hsa-miR-135a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004595 hsa-miR-135a* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034266 MIMAT0004595 hsa-miR-135a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004595 hsa-miR-135a* miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00034267 MIMAT0004595 hsa-miR-135a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004595 hsa-miR-135a* miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00034268 MIMAT0004596 hsa-miR-138-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004596 hsa-miR-138-2* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034269 MIMAT0004596 hsa-miR-138-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004596 hsa-miR-138-2* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034270 MIMAT0004596 hsa-miR-138-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004596 hsa-miR-138-2* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034271 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034272 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034273 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034274 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034275 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034276 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034277 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00034278 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034279 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00034280 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034281 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034282 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034283 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034284 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00034285 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00034286 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034287 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034288 MIMAT0004597 hsa-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004597 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034289 MIMAT0004598 hsa-miR-141-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004598 hsa-miR-141* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034290 MIMAT0004598 hsa-miR-141-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004598 hsa-miR-141* miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00034291 MIMAT0004598 hsa-miR-141-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004598 hsa-miR-141* miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00034292 MIMAT0004599 hsa-miR-143-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004599 hsa-miR-143* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034293 MIMAT0004599 hsa-miR-143-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004599 hsa-miR-143* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034294 MIMAT0004599 hsa-miR-143-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004599 hsa-miR-143* miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In contrast to oncomirs, an miRNA that is involved in tumor-suppressing activities, is taken as a tumor suppressor (oncosuppressor). The aberrantly expressed miR-223, which directly targeted Stathmin 1 to inhibit HCC growth, was only found in MVs of liver cancer cell line in our study (table 2). Data are collected from Table 2. " RLID00034295 MIMAT0004599 hsa-miR-143-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004599 hsa-miR-143* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034296 MIMAT0004600 hsa-miR-144-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004600 hsa-miR-144* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034297 MIMAT0004600 hsa-miR-144-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004600 hsa-miR-144* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034298 MIMAT0004600 hsa-miR-144-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004600 hsa-miR-144* miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00034299 MIMAT0004600 hsa-miR-144-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004600 hsa-miR-144* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034300 MIMAT0004600 hsa-miR-144-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004600 hsa-miR-144* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034301 MIMAT0004600 hsa-miR-144-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004600 hsa-miR-144* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034302 MIMAT0004601 hsa-miR-145-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004601 hsa-miR-145* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034303 MIMAT0004601 hsa-miR-145-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004601 hsa-miR-145* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034304 MIMAT0004601 hsa-miR-145-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004601 hsa-miR-145* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034305 MIMAT0004601 hsa-miR-145-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004601 hsa-miR-145* miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00034306 MIMAT0004601 hsa-miR-145-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004601 hsa-miR-145* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034307 MIMAT0004601 hsa-miR-145-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004601 hsa-miR-145* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034308 MIMAT0004602 hsa-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004602 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034309 MIMAT0004602 hsa-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004602 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034310 MIMAT0004602 hsa-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004602 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034311 MIMAT0004602 hsa-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004602 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034312 MIMAT0004602 hsa-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004602 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034313 MIMAT0004602 hsa-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004602 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034314 MIMAT0004602 hsa-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004602 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00034315 MIMAT0004602 hsa-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004602 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034316 MIMAT0004602 hsa-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004602 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034317 MIMAT0004602 hsa-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004602 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034318 MIMAT0004602 hsa-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004602 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034319 MIMAT0004602 hsa-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004602 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00034320 MIMAT0004602 hsa-miR-125a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004602 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00034321 MIMAT0004603 hsa-miR-125b-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004603 hsa-miR-125b-2* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034322 MIMAT0004603 hsa-miR-125b-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004603 hsa-miR-125b-2* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034323 MIMAT0004603 hsa-miR-125b-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004603 hsa-miR-125b-2* miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00034324 MIMAT0004603 hsa-miR-125b-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004603 hsa-miR-125b-2* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034325 MIMAT0004603 hsa-miR-125b-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004603 hsa-miR-125b-2* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034326 MIMAT0004603 hsa-miR-125b-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004603 hsa-miR-125b-2* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034327 MIMAT0004603 hsa-miR-125b-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004603 hsa-miR-125b-2* miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00034328 MIMAT0004603 hsa-miR-125b-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004603 hsa-miR-125b-2* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034329 MIMAT0004604 hsa-miR-127-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004604 miRNA Homo sapiens 22798503 Circulating Serum qRT-PCR "Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages. " RLID00034330 MIMAT0004604 hsa-miR-127-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004604 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034331 MIMAT0004604 hsa-miR-127-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004604 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00034332 MIMAT0004604 hsa-miR-127-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004604 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00034333 MIMAT0004605 hsa-miR-129-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004605 hsa-miR-129-3p miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034334 MIMAT0004605 hsa-miR-129-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004605 hsa-miR-129-3p miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034335 MIMAT0004605 hsa-miR-129-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004605 hsa-miR-129-3p miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034336 MIMAT0004605 hsa-miR-129-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004605 hsa-miR-129-3p miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034337 MIMAT0004605 hsa-miR-129-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004605 hsa-miR-129-3p miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00034338 MIMAT0004606 hsa-miR-136-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004606 hsa-miR-136* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034339 MIMAT0004606 hsa-miR-136-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004606 hsa-miR-136* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034340 MIMAT0004606 hsa-miR-136-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004606 hsa-miR-136* miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034341 MIMAT0004606 hsa-miR-136-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004606 hsa-miR-136* miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00034342 MIMAT0004606 hsa-miR-136-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004606 hsa-miR-136* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034343 MIMAT0004606 hsa-miR-136-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004606 hsa-miR-136* miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00034344 MIMAT0004607 hsa-miR-138-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004607 hsa-miR-138-1* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034345 MIMAT0004607 hsa-miR-138-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004607 hsa-miR-138-1* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034346 MIMAT0004609 hsa-miR-149-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004609 hsa-miR-149* miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00034347 MIMAT0004609 hsa-miR-149-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004609 hsa-miR-149* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034348 MIMAT0004609 hsa-miR-149-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004609 hsa-miR-149* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034349 MIMAT0004609 hsa-miR-149-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004609 hsa-miR-149* miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00034350 MIMAT0004609 hsa-miR-149-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004609 hsa-miR-149* miRNA Homo sapiens 24468161 Exosome Breast cancer cell RT-PCR|Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00034351 MIMAT0004609 hsa-miR-149-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004609 hsa-miR-149* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034352 MIMAT0004609 hsa-miR-149-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004609 hsa-miR-149* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034353 MIMAT0004610 hsa-miR-150-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004610 hsa-miR-150* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034354 MIMAT0004610 hsa-miR-150-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004610 hsa-miR-150* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034355 MIMAT0004610 hsa-miR-150-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004610 hsa-miR-150* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034356 MIMAT0004610 hsa-miR-150-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004610 hsa-miR-150* miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00034357 MIMAT0004610 hsa-miR-150-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004610 hsa-miR-150* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034358 MIMAT0004610 hsa-miR-150-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004610 hsa-miR-150* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034359 MIMAT0004610 hsa-miR-150-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004610 hsa-miR-150* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034360 MIMAT0004610 hsa-miR-150-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004610 hsa-miR-150* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034361 MIMAT0004610 hsa-miR-150-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004610 hsa-miR-150* miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00034362 MIMAT0004611 hsa-miR-185-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004611 hsa-miR-185* miRNA Homo sapiens 20145944 Circulating Blood RT-PCR|Microarray "Our results highlight four miRNA markers for blood identification (miR-20a, miR-106a, miR-185, and miR-144) and five for semen identification (miR-135a, miR-10a, miR-507, miR-943, and miR-891a). Of those, two miRNA markers for blood (miR-144 and miR-185) and two others for semen (miR-135a and miR-897a) are suggestive to be most useful for body fluid identification in future forensic applications, and the respective RT-PCR assays used here for their detection were highly sensitive, allowing the reliable marker detection from subpicogram amounts of total RNA. Our results proved the applicability of the miRNA approach for forensic body fluids identification. " RLID00034363 MIMAT0004611 hsa-miR-185-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004611 hsa-miR-185* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034364 MIMAT0004611 hsa-miR-185-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004611 hsa-miR-185* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034365 MIMAT0004611 hsa-miR-185-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004611 hsa-miR-185* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034366 MIMAT0004611 hsa-miR-185-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004611 hsa-miR-185* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034367 MIMAT0004611 hsa-miR-185-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004611 hsa-miR-185* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034368 MIMAT0004611 hsa-miR-185-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004611 hsa-miR-185* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034369 MIMAT0004612 hsa-miR-186-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004612 hsa-miR-186* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034370 MIMAT0004613 hsa-miR-188-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004613 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034371 MIMAT0004613 hsa-miR-188-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004613 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034372 MIMAT0004613 hsa-miR-188-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004613 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034373 MIMAT0004614 hsa-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004614 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034374 MIMAT0004614 hsa-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004614 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034375 MIMAT0004614 hsa-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004614 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034376 MIMAT0004614 hsa-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004614 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034377 MIMAT0004614 hsa-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004614 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034378 MIMAT0004614 hsa-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004614 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034379 MIMAT0004614 hsa-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004614 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034380 MIMAT0004614 hsa-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004614 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034381 MIMAT0004614 hsa-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004614 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034382 MIMAT0004614 hsa-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004614 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00034383 MIMAT0004614 hsa-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004614 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034384 MIMAT0004614 hsa-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004614 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034385 MIMAT0004615 hsa-miR-195-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004615 hsa-miR-195* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034386 MIMAT0004615 hsa-miR-195-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004615 hsa-miR-195* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034387 MIMAT0004615 hsa-miR-195-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004615 hsa-miR-195* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034388 MIMAT0004620 mmu-let-7a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004620 "mmu-let-7a*, mmu-let-7a-1* " miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00034389 MIMAT0004622 mmu-let-7c-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004622 mmu-let-7c-1* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034390 MIMAT0004625 mmu-miR-16-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004625 "mmu-miR-16*, mmu-miR-16-1* " miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034391 MIMAT0004626 mmu-miR-18a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004626 mmu-miR-18a* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034392 MIMAT0004626 mmu-miR-18a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004626 mmu-miR-18a* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034393 MIMAT0004627 mmu-miR-20a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004627 mmu-miR-20a* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034394 MIMAT0004628 mmu-miR-21a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004628 "mmu-miR-21*, mmu-miR-21-3p " miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00034395 MIMAT0004629 mmu-miR-22-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004629 mmu-miR-22* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034396 MIMAT0004629 mmu-miR-22-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004629 mmu-miR-22* miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00034397 MIMAT0004629 mmu-miR-22-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004629 mmu-miR-22* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034398 MIMAT0004630 mmu-miR-26b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004630 mmu-miR-26b* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034399 MIMAT0004631 mmu-miR-29a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004631 mmu-miR-29a* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034400 MIMAT0004636 mmu-miR-93-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004636 mmu-miR-93* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034401 MIMAT0004640 mmu-miR-325-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004640 mmu-miR-325 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034402 MIMAT0004640 mmu-miR-325-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004640 mmu-miR-325 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00034403 MIMAT0004642 mmu-miR-330-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004642 mmu-miR-330 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034404 MIMAT0004643 mmu-miR-331-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004643 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034405 MIMAT0004643 mmu-miR-331-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004643 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034406 MIMAT0004644 mmu-miR-337-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004644 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034407 MIMAT0004646 rno-miR-338-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004646 rno-miR-338* miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00034408 MIMAT0004647 mmu-miR-338-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004647 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034409 MIMAT0004648 rno-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004648 miRNA Rattus norvegicus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034410 MIMAT0004649 mmu-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004649 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034411 MIMAT0004650 rno-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004650 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00034412 MIMAT0004650 rno-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004650 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Five miRNAs, miR-340-5p, miR-351, miR-494, miR-664, and let-7e, were significantly concentrated (two- to eightfold) in the nucleolus compared with the nucleoplasm and/or the cytoplasm (Fig. 2A; Supplemental Table 1). " RLID00034413 MIMAT0004651 mmu-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004651 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034414 MIMAT0004651 mmu-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004651 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034415 MIMAT0004651 mmu-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004651 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034416 MIMAT0004652 rno-miR-342-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004652 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00034417 MIMAT0004653 mmu-miR-342-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004653 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034418 MIMAT0004653 mmu-miR-342-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004653 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034419 MIMAT0004655 rno-miR-345-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004655 miRNA Rattus norvegicus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034420 MIMAT0004656 mmu-miR-345-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004656 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034421 MIMAT0004661 mmu-miR-28a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004661 "mmu-miR-28*, mmu-miR-28-3p " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034422 MIMAT0004662 mmu-miR-139-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004662 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034423 MIMAT0004663 mmu-miR-200c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004663 mmu-miR-200c* miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00034424 MIMAT0004667 mmu-miR-199b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004667 mmu-miR-199b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034425 MIMAT0004669 mmu-miR-125b-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004669 mmu-miR-125b-3p miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034426 MIMAT0004670 mmu-miR-7a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004670 "mmu-miR-7a*, mmu-miR-7a-1* " miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034427 MIMAT0004672 hsa-miR-106b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004672 hsa-miR-106b* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034428 MIMAT0004672 hsa-miR-106b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004672 hsa-miR-106b* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034429 MIMAT0004672 hsa-miR-106b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004672 hsa-miR-106b* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034430 MIMAT0004672 hsa-miR-106b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004672 hsa-miR-106b* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034431 MIMAT0004672 hsa-miR-106b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004672 hsa-miR-106b* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034432 MIMAT0004672 hsa-miR-106b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004672 hsa-miR-106b* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034433 MIMAT0004672 hsa-miR-106b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004672 hsa-miR-106b* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034434 MIMAT0004672 hsa-miR-106b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004672 hsa-miR-106b* miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00034435 MIMAT0004672 hsa-miR-106b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004672 hsa-miR-106b* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034436 MIMAT0004672 hsa-miR-106b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004672 hsa-miR-106b* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034437 MIMAT0004672 hsa-miR-106b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004672 hsa-miR-106b* miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00034438 MIMAT0004672 hsa-miR-106b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004672 hsa-miR-106b* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034439 MIMAT0004673 hsa-miR-29c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004673 hsa-miR-29c* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034440 MIMAT0004673 hsa-miR-29c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004673 hsa-miR-29c* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034441 MIMAT0004673 hsa-miR-29c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004673 hsa-miR-29c* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034442 MIMAT0004673 hsa-miR-29c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004673 hsa-miR-29c* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034443 MIMAT0004673 hsa-miR-29c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004673 hsa-miR-29c* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034444 MIMAT0004674 hsa-miR-30c-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004674 hsa-miR-30c-1* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034445 MIMAT0004674 hsa-miR-30c-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004674 hsa-miR-30c-1* miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00034446 MIMAT0004674 hsa-miR-30c-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004674 hsa-miR-30c-1* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034447 MIMAT0004674 hsa-miR-30c-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004674 hsa-miR-30c-1* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034448 MIMAT0004674 hsa-miR-30c-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004674 hsa-miR-30c-1* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034449 MIMAT0004675 hsa-miR-219a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004675 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034450 MIMAT0004675 hsa-miR-219a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004675 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034451 MIMAT0004675 hsa-miR-219a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004675 miRNA Homo sapiens 22094284 Circulating serum qRT-PCR|RNA-seq "When compared with family schizophrenia patients, circulating miR-219-2-3p, miR-92a, miR-346, let-7g and miR-17 were significantly higher in sporadic schizophrenia ( p < 0.001, Fig. 4 ). On contrary, miR-181b and miR-195 were significantlydown-regulated in sporadic schizophrenia compared with family schizophrenia patients ( p < 0.001), miR-1308 was slightly lower in sporadic schizophrenia compared family schizophrenia patients (0.05 < p < 0.001), and miR-103 was highly consistent between sporadic schizophrenia and family schizophrenia patients ( p > 0.05). These data indicate that there is a close relationship between levels of circulating miRNAs and schizophrenia patients whether they have the family history or not. " RLID00034452 MIMAT0004675 hsa-miR-219a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004675 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00034453 MIMAT0004675 hsa-miR-219a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004675 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034454 MIMAT0004676 hsa-miR-34b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004676 hsa-miR-34b miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00034455 MIMAT0004676 hsa-miR-34b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004676 hsa-miR-34b miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034456 MIMAT0004676 hsa-miR-34b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004676 hsa-miR-34b miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034457 MIMAT0004676 hsa-miR-34b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004676 hsa-miR-34b miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00034458 MIMAT0004677 hsa-miR-34c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004677 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034459 MIMAT0004678 hsa-miR-99b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004678 hsa-miR-99b* miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034460 MIMAT0004678 hsa-miR-99b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004678 hsa-miR-99b* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034461 MIMAT0004678 hsa-miR-99b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004678 hsa-miR-99b* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034462 MIMAT0004678 hsa-miR-99b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004678 hsa-miR-99b* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034463 MIMAT0004678 hsa-miR-99b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004678 hsa-miR-99b* miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034464 MIMAT0004678 hsa-miR-99b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004678 hsa-miR-99b* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034465 MIMAT0004678 hsa-miR-99b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004678 hsa-miR-99b* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034466 MIMAT0004678 hsa-miR-99b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004678 hsa-miR-99b* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034467 MIMAT0004678 hsa-miR-99b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004678 hsa-miR-99b* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034468 MIMAT0004679 hsa-miR-296-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004679 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034469 MIMAT0004680 hsa-miR-130b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004680 hsa-miR-130b* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034470 MIMAT0004680 hsa-miR-130b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004680 hsa-miR-130b* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034471 MIMAT0004680 hsa-miR-130b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004680 hsa-miR-130b* miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00034472 MIMAT0004680 hsa-miR-130b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004680 hsa-miR-130b* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034473 MIMAT0004680 hsa-miR-130b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004680 hsa-miR-130b* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034474 MIMAT0004681 hsa-miR-26a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004681 hsa-miR-26a-2* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034475 MIMAT0004681 hsa-miR-26a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004681 hsa-miR-26a-2* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034476 MIMAT0004681 hsa-miR-26a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004681 hsa-miR-26a-2* miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00034477 MIMAT0004682 hsa-miR-361-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004682 miRNA Homo sapiens 22675530 Circulating Serum qRT-PCR Low levels of cell-free circulating miR-361-3p and miR-625* as blood-based markers for discriminating malignant from benign lung tumors. RLID00034478 MIMAT0004682 hsa-miR-361-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004682 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034479 MIMAT0004682 hsa-miR-361-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004682 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034480 MIMAT0004682 hsa-miR-361-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004682 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034481 MIMAT0004682 hsa-miR-361-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004682 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034482 MIMAT0004682 hsa-miR-361-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004682 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034483 MIMAT0004682 hsa-miR-361-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004682 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034484 MIMAT0004682 hsa-miR-361-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004682 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034485 MIMAT0004682 hsa-miR-361-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004682 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034486 MIMAT0004683 hsa-miR-362-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004683 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034487 MIMAT0004683 hsa-miR-362-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004683 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034488 MIMAT0004683 hsa-miR-362-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004683 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034489 MIMAT0004683 hsa-miR-362-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004683 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034490 MIMAT0004683 hsa-miR-362-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004683 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00034491 MIMAT0004684 mmu-miR-362-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004684 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034492 MIMAT0004684 mmu-miR-362-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004684 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034493 MIMAT0004684 mmu-miR-362-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004684 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034494 MIMAT0004686 hsa-miR-367-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004686 hsa-miR-367* miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00034495 MIMAT0004686 hsa-miR-367-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004686 hsa-miR-367* miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00034496 MIMAT0004687 hsa-miR-371a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004687 hsa-miR-371-5p miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034497 MIMAT0004687 hsa-miR-371a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004687 hsa-miR-371-5p miRNA Homo sapiens 24259014 Circulating Serum Microarray "Elevated Serum Level of MicroRNA (miRNA)-200c nd miRNA-371-5p in Children with Kawasaki Disease. Two miRNAs, miR-200c and miR-371-5p, were differentially expressed between children with and without KD (Fig.2). Both miRNAs were significantly upregulated in the KD group compared with the control group (p=0.032 in both). " RLID00034498 MIMAT0004687 hsa-miR-371a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004687 hsa-miR-371-5p miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034499 MIMAT0004687 hsa-miR-371a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004687 hsa-miR-371-5p miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034500 MIMAT0004687 hsa-miR-371a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004687 hsa-miR-371-5p miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034501 MIMAT0004689 hsa-miR-377-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004689 hsa-miR-377* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034502 MIMAT0004689 hsa-miR-377-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004689 hsa-miR-377* miRNA Homo sapiens 24352417 Circulating Blood platelet Next-generation sequencing "Platelets in both groups demonstrated miRNA expression profiles comparable to previously published data. The statistical analysis unveiled a signature of only three miRNAs (miR-377-5p, miR-628-3p, miR-3137) with high reselection probabilities in resampling techniques. " RLID00034503 MIMAT0004689 hsa-miR-377-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004689 hsa-miR-377* miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00034504 MIMAT0004690 hsa-miR-379-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004690 hsa-miR-379* miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00034505 MIMAT0004690 hsa-miR-379-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004690 hsa-miR-379* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034506 MIMAT0004690 hsa-miR-379-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004690 hsa-miR-379* miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00034507 MIMAT0004692 hsa-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004692 hsa-miR-340 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034508 MIMAT0004692 hsa-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004692 hsa-miR-340 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034509 MIMAT0004692 hsa-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004692 hsa-miR-340 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034510 MIMAT0004692 hsa-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004692 hsa-miR-340 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00034511 MIMAT0004692 hsa-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004692 hsa-miR-340 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034512 MIMAT0004692 hsa-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004692 hsa-miR-340 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034513 MIMAT0004692 hsa-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004692 hsa-miR-340 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034514 MIMAT0004692 hsa-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004692 hsa-miR-340 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034515 MIMAT0004692 hsa-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004692 hsa-miR-340 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034516 MIMAT0004692 hsa-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004692 hsa-miR-340 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00034517 MIMAT0004692 hsa-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004692 hsa-miR-340 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00034518 MIMAT0004692 hsa-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004692 hsa-miR-340 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034519 MIMAT0004692 hsa-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004692 hsa-miR-340 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034520 MIMAT0004692 hsa-miR-340-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004692 hsa-miR-340 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034521 MIMAT0004693 hsa-miR-330-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004693 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034522 MIMAT0004693 hsa-miR-330-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004693 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034523 MIMAT0004693 hsa-miR-330-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004693 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034524 MIMAT0004693 hsa-miR-330-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004693 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034525 MIMAT0004694 hsa-miR-342-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004694 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034526 MIMAT0004694 hsa-miR-342-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004694 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034527 MIMAT0004694 hsa-miR-342-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004694 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034528 MIMAT0004694 hsa-miR-342-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004694 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034529 MIMAT0004694 hsa-miR-342-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004694 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034530 MIMAT0004694 hsa-miR-342-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004694 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034531 MIMAT0004694 hsa-miR-342-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004694 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034532 MIMAT0004694 hsa-miR-342-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004694 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034533 MIMAT0004694 hsa-miR-342-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004694 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034534 MIMAT0004694 hsa-miR-342-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004694 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034535 MIMAT0004695 hsa-miR-337-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004695 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034536 MIMAT0004695 hsa-miR-337-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004695 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034537 MIMAT0004695 hsa-miR-337-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004695 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034538 MIMAT0004696 hsa-miR-323a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004696 hsa-miR-323-5p miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034539 MIMAT0004696 hsa-miR-323a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004696 hsa-miR-323-5p miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00034540 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034541 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034542 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034543 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034544 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00034545 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034546 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034547 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034548 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034549 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034550 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034551 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034552 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034553 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034554 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034555 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034556 MIMAT0004697 hsa-miR-151a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004697 hsa-miR-151-5p miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034557 MIMAT0004700 hsa-miR-331-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004700 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034558 MIMAT0004700 hsa-miR-331-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004700 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034559 MIMAT0004700 hsa-miR-331-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004700 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034560 MIMAT0004700 hsa-miR-331-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004700 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00034561 MIMAT0004700 hsa-miR-331-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004700 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034562 MIMAT0004700 hsa-miR-331-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004700 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034563 MIMAT0004701 hsa-miR-338-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004701 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034564 MIMAT0004701 hsa-miR-338-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004701 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034565 MIMAT0004701 hsa-miR-338-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004701 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034566 MIMAT0004701 hsa-miR-338-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004701 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034567 MIMAT0004701 hsa-miR-338-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004701 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034568 MIMAT0004701 hsa-miR-338-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004701 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034569 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034570 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034571 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034572 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034573 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034574 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034575 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034576 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034577 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034578 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034579 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00034580 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034581 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034582 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034583 MIMAT0004702 hsa-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004702 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00034584 MIMAT0004703 hsa-miR-335-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004703 hsa-miR-335* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034585 MIMAT0004703 hsa-miR-335-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004703 hsa-miR-335* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034586 MIMAT0004703 hsa-miR-335-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004703 hsa-miR-335* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034587 MIMAT0004705 rno-let-7b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004705 rno-let-7b* miRNA Rattus norvegicus 24324399 Nucleus Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00034588 MIMAT0004713 rno-miR-25-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004713 rno-miR-25* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00034589 MIMAT0004728 rno-miR-124-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004728 rno-miR-124* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00034590 MIMAT0004730 rno-miR-125b-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004730 rno-miR-125b-3p miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00034591 MIMAT0004730 rno-miR-125b-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004730 rno-miR-125b-3p miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00034592 MIMAT0004734 rno-miR-138-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004734 "rno-miR-138*, rno-miR-138-1* " miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00034593 MIMAT0004735 rno-miR-139-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004735 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00034594 MIMAT0004736 rno-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004736 rno-miR-193-5p miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00034595 MIMAT0004738 rno-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004738 miRNA Rattus norvegicus 19628621 Nucleoplasm Myoblast In situ hybridization "MiR-199a-3p and miR-125a-5p appeared more concentrated in the nucleoplasm and cytoplasm compared with the nucleolus; their hybridization pattern more closely resembled that of let-7a, a microRNA that earlier in situ hybridization experiments had shown not to be concentrated in the nucleolus (Fig. 3; Politz et al. 2006). " RLID00034596 MIMAT0004738 rno-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004738 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast In situ hybridization "MiR-199a-3p and miR-125a-5p appeared more concentrated in the nucleoplasm and cytoplasm compared with the nucleolus; their hybridization pattern more closely resembled that of let-7a, a microRNA that earlier in situ hybridization experiments had shown not to be concentrated in the nucleolus (Fig. 3; Politz et al. 2006). " RLID00034597 MIMAT0004741 rno-miR-219a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004741 miRNA Rattus norvegicus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034598 MIMAT0004745 mmu-miR-384-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004745 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034599 MIMAT0004745 mmu-miR-384-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004745 miRNA Mus musculus 24381269 Axon DRG neuron qRT-PCR "We only considered miRNAs with average CT (threshold cycle) values lower than 35, since a mature miRNA CT >35 is reported to be below the reliable detection limit (Chen et al., 2009). The axonal miRNAs were also ranked in order of abundance in axons (Fig. 2E; Table 1). Of the top 20 most abundant axonal miRNAs, only 11 were >1.5-fold enriched in axons, indicating that enrichment is not a simple reflection of abundance. Data are collected from Table 1. " RLID00034600 MIMAT0004747 mmu-miR-411-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004747 mmu-miR-411 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034601 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034602 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034603 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034604 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034605 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 24456939 Circulating Serum - "In gastric cancer, several circulating miRNAs have been studied as potential diagnostic biomarkers by evaluating their amount in serum, plasma and gastric juice (Table 2). Data are collected from Table 2. " RLID00034606 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034607 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034608 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00034609 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00034610 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00034611 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00034612 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034613 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034614 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034615 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034616 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034617 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034618 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00034619 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00034620 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00034621 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034622 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034623 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 24937531 Exosome Plasma qRT-PCR "For miRNome analysis, two homogeneous samples were created: one by pooling 2 μL of RNA from exosomes of diabetic patients and the other by pooling RNA from exosomes of control subjects. After reverse transcription (mirCURY LNA universal cDNA synthesis kit; Exiqon), the reaction was performed on a serum/plasma focus miRNA PCR panel 384 well (V1.R) (Exiqon) using the ABI 7900HT (Applied Biosystems). The most stable miRNAs (miR-425 and miR-423-5p) were identified by NormFinder and GeNorm, validated on each sample, and used as normalizators for circulating miRNAs. - See more at: http://press.endocrine.org/doi/10.1210/jc.2013-3843?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&#sthash.kodyGYkk.dpuf " RLID00034624 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034625 MIMAT0004748 hsa-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004748 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034626 MIMAT0004749 hsa-miR-424-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004749 hsa-miR-424* miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034627 MIMAT0004749 hsa-miR-424-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004749 hsa-miR-424* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034628 MIMAT0004749 hsa-miR-424-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004749 hsa-miR-424* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034629 MIMAT0004749 hsa-miR-424-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004749 hsa-miR-424* miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034630 MIMAT0004749 hsa-miR-424-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004749 hsa-miR-424* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034631 MIMAT0004749 hsa-miR-424-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004749 hsa-miR-424* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034632 MIMAT0004749 hsa-miR-424-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004749 hsa-miR-424* miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034633 MIMAT0004749 hsa-miR-424-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004749 hsa-miR-424* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034634 MIMAT0004749 hsa-miR-424-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004749 hsa-miR-424* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034635 MIMAT0004749 hsa-miR-424-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004749 hsa-miR-424* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034636 MIMAT0004749 hsa-miR-424-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004749 hsa-miR-424* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034637 MIMAT0004749 hsa-miR-424-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004749 hsa-miR-424* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034638 MIMAT0004750 mmu-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004750 mmu-miR-425 miRNA Mus musculus 18410515 Synapse ForeBrain Microarray Table 3: microRNAs most and least enriched in synaptoneurosomes as measured by microarray. Data are collected from Table 3. RLID00034639 MIMAT0004751 hsa-miR-18b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004751 hsa-miR-18b* miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034640 MIMAT0004752 hsa-miR-20b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004752 hsa-miR-20b* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034641 MIMAT0004752 hsa-miR-20b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004752 hsa-miR-20b* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034642 MIMAT0004752 hsa-miR-20b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004752 hsa-miR-20b* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034643 MIMAT0004755 hcmv-miR-US25-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004755 hcmv-miR-US25-1* miRNA Human herpesvirus 5 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00034644 MIMAT0004757 hsa-miR-431-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004757 hsa-miR-431* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034645 MIMAT0004757 hsa-miR-431-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004757 hsa-miR-431* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034646 MIMAT0004757 hsa-miR-431-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004757 hsa-miR-431* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034647 MIMAT0004757 hsa-miR-431-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004757 hsa-miR-431* miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00034648 MIMAT0004758 mmu-miR-463-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004758 mmu-miR-463 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034649 MIMAT0004759 mmu-miR-466a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004759 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034650 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034651 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034652 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034653 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00034654 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00034655 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00034656 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034657 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034658 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034659 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034660 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034661 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034662 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00034663 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00034664 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00034665 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 22529849 Exosome Liver carcinoma cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00034666 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00034667 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034668 MIMAT0004761 hsa-miR-483-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004761 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034669 MIMAT0004762 hsa-miR-486-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004762 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034670 MIMAT0004762 hsa-miR-486-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004762 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034671 MIMAT0004762 hsa-miR-486-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004762 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034672 MIMAT0004762 hsa-miR-486-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004762 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034673 MIMAT0004762 hsa-miR-486-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004762 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034674 MIMAT0004762 hsa-miR-486-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004762 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034675 MIMAT0004762 hsa-miR-486-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004762 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034676 MIMAT0004762 hsa-miR-486-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004762 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00034677 MIMAT0004763 hsa-miR-488-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004763 hsa-miR-488 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00034678 MIMAT0004763 hsa-miR-488-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004763 hsa-miR-488 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00034679 MIMAT0004763 hsa-miR-488-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004763 hsa-miR-488 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00034680 MIMAT0004763 hsa-miR-488-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004763 hsa-miR-488 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00034681 MIMAT0004763 hsa-miR-488-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004763 hsa-miR-488 miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00034682 MIMAT0004764 hsa-miR-490-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004764 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034683 MIMAT0004764 hsa-miR-490-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004764 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034684 MIMAT0004766 hsa-miR-146b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004766 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034685 MIMAT0004766 hsa-miR-146b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004766 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034686 MIMAT0004766 hsa-miR-146b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004766 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034687 MIMAT0004767 hsa-miR-193b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004767 hsa-miR-193b* miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034688 MIMAT0004767 hsa-miR-193b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004767 hsa-miR-193b* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034689 MIMAT0004767 hsa-miR-193b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004767 hsa-miR-193b* miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034690 MIMAT0004767 hsa-miR-193b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004767 hsa-miR-193b* miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00034691 MIMAT0004767 hsa-miR-193b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004767 hsa-miR-193b* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034692 MIMAT0004767 hsa-miR-193b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004767 hsa-miR-193b* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034693 MIMAT0004767 hsa-miR-193b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004767 hsa-miR-193b* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034694 MIMAT0004767 hsa-miR-193b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004767 hsa-miR-193b* miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034695 MIMAT0004767 hsa-miR-193b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004767 hsa-miR-193b* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034696 MIMAT0004767 hsa-miR-193b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004767 hsa-miR-193b* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034697 MIMAT0004767 hsa-miR-193b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004767 hsa-miR-193b* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034698 MIMAT0004767 hsa-miR-193b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004767 hsa-miR-193b* miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00034699 MIMAT0004767 hsa-miR-193b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004767 hsa-miR-193b* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034700 MIMAT0004767 hsa-miR-193b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004767 hsa-miR-193b* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034701 MIMAT0004770 hsa-miR-516a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004770 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034702 MIMAT0004773 hsa-miR-500a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004773 "hsa-miR-500, hsa-miR-500a " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034703 MIMAT0004773 hsa-miR-500a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004773 "hsa-miR-500, hsa-miR-500a " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034704 MIMAT0004773 hsa-miR-500a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004773 "hsa-miR-500, hsa-miR-500a " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034705 MIMAT0004773 hsa-miR-500a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004773 "hsa-miR-500, hsa-miR-500a " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034706 MIMAT0004774 hsa-miR-501-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004774 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034707 MIMAT0004774 hsa-miR-501-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004774 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034708 MIMAT0004774 hsa-miR-501-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004774 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034709 MIMAT0004774 hsa-miR-501-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004774 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034710 MIMAT0004774 hsa-miR-501-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004774 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034711 MIMAT0004774 hsa-miR-501-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004774 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034712 MIMAT0004774 hsa-miR-501-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004774 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034713 MIMAT0004774 hsa-miR-501-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004774 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034714 MIMAT0004774 hsa-miR-501-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004774 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034715 MIMAT0004774 hsa-miR-501-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004774 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034716 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034717 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034718 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034719 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034720 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034721 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034722 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00034723 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034724 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034725 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034726 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00034727 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034728 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034729 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034730 MIMAT0004775 hsa-miR-502-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004775 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034731 MIMAT0004776 hsa-miR-505-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004776 hsa-miR-505* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034732 MIMAT0004776 hsa-miR-505-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004776 hsa-miR-505* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034733 MIMAT0004776 hsa-miR-505-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004776 hsa-miR-505* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034734 MIMAT0004776 hsa-miR-505-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004776 hsa-miR-505* miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00034735 MIMAT0004776 hsa-miR-505-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004776 hsa-miR-505* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034736 MIMAT0004776 hsa-miR-505-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004776 hsa-miR-505* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034737 MIMAT0004777 hsa-miR-513a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004777 hsa-miR-513-3p miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034738 MIMAT0004777 hsa-miR-513a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004777 hsa-miR-513-3p miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034739 MIMAT0004777 hsa-miR-513a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004777 hsa-miR-513-3p miRNA Homo sapiens 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00034740 MIMAT0004777 hsa-miR-513a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004777 hsa-miR-513-3p miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00034741 MIMAT0004778 hsa-miR-508-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004778 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00034742 MIMAT0004779 hsa-miR-509-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004779 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034743 MIMAT0004779 hsa-miR-509-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004779 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034744 MIMAT0004780 hsa-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004780 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034745 MIMAT0004780 hsa-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004780 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034746 MIMAT0004780 hsa-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004780 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034747 MIMAT0004780 hsa-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004780 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034748 MIMAT0004780 hsa-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004780 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034749 MIMAT0004780 hsa-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004780 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034750 MIMAT0004780 hsa-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004780 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034751 MIMAT0004780 hsa-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004780 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034752 MIMAT0004780 hsa-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004780 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034753 MIMAT0004781 mmu-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004781 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034754 MIMAT0004781 mmu-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004781 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034755 MIMAT0004781 mmu-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004781 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034756 MIMAT0004781 mmu-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004781 miRNA Mus musculus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00034757 MIMAT0004784 hsa-miR-455-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004784 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00034758 MIMAT0004784 hsa-miR-455-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004784 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034759 MIMAT0004784 hsa-miR-455-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004784 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034760 MIMAT0004784 hsa-miR-455-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004784 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034761 MIMAT0004784 hsa-miR-455-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004784 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034762 MIMAT0004784 hsa-miR-455-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004784 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034763 MIMAT0004784 hsa-miR-455-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004784 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034764 MIMAT0004785 hsa-miR-545-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004785 hsa-miR-545* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034765 MIMAT0004790 mmu-miR-503-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004790 mmu-miR-503* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034766 MIMAT0004792 hsa-miR-92b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004792 hsa-miR-92b* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034767 MIMAT0004792 hsa-miR-92b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004792 hsa-miR-92b* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034768 MIMAT0004792 hsa-miR-92b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004792 hsa-miR-92b* miRNA Homo sapiens 24468161 Exosome Breast cancer cell RT-PCR|Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00034769 MIMAT0004792 hsa-miR-92b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004792 hsa-miR-92b* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034770 MIMAT0004792 hsa-miR-92b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004792 hsa-miR-92b* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034771 MIMAT0004792 hsa-miR-92b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004792 hsa-miR-92b* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034772 MIMAT0004794 hsa-miR-551b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004794 hsa-miR-551b* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034773 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 21258252 Circulating Serum qRT-PCR The utility of miR-1254 and miR-574-5p serum-based biomarkers as minimally invasive screening and triage tools for subsequent diagnostic evaluation warrants additional validation. RLID00034774 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 22344312 Circulating Serum Microarray|qRT-PCR "Serum micro-RNAs (miRNAs) can be used for the diagnosis and prognosis of various diseases. Using genome-wide scans, we sought to identify serum miRNAs that could be used as prognostic predictors for sepsis patients. We used microarray screens to identify differentially expressed serum miRNAs by comparing samples from 12 surviving and 12 nonsurviving sepsis patients. These differentially expressed serum miRNAs were validated by quantitative reverse transcriptase-polymerase chain reaction assays for 118 sepsis patients. The validated miRNAs along with sepsis patients' clinical indictors were analyzed in a multivariate logistic regression model. Microarray analysis showed that miR-297 and miR-574-5p were differentially expressed in sepsis survivors and nonsurvivors. Upon validation with 118 sepsis patients' samples, these two miRNA expressions were significantly different, with P < 0.001. miR-297 was more closely associated with survival from sepsis, whereas miR-574-5p was associated with death from sepsis. " RLID00034775 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034776 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034777 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00034778 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034779 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00034780 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 23169280 Circulating Serum Microarray "Table 2 miRNAs detected in pooled patient and control samples, as detected by Agilent Human miRNA microarrays. All of these showed potential as biomarkers as the levels of miRNAs varied between the patient and control groups. The expression levels of six of these miRNAs (in bold) were verified using TaqMan qRT–PCR. Three miRNAs (miR-720, miR-1246 and miR-1308) chosen for further analysis in individual patient samples. TaqMan qRT–PCR assays for the remaining three miRNAs were not available or were unreliable. Data are collected from Table 2. " RLID00034781 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034782 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034783 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034784 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034785 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 25330373 Extracellular vesicle Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00034786 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034787 MIMAT0004795 hsa-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004795 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034788 MIMAT0004796 hsa-miR-576-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004796 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034789 MIMAT0004796 hsa-miR-576-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004796 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034790 MIMAT0004796 hsa-miR-576-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004796 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00034791 MIMAT0004797 hsa-miR-582-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004797 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034792 MIMAT0004797 hsa-miR-582-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004797 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034793 MIMAT0004797 hsa-miR-582-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004797 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034794 MIMAT0004799 hsa-miR-589-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004799 hsa-miR-589 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034795 MIMAT0004799 hsa-miR-589-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004799 hsa-miR-589 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034796 MIMAT0004799 hsa-miR-589-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004799 hsa-miR-589 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034797 MIMAT0004799 hsa-miR-589-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004799 hsa-miR-589 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034798 MIMAT0004799 hsa-miR-589-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004799 hsa-miR-589 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034799 MIMAT0004799 hsa-miR-589-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004799 hsa-miR-589 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034800 MIMAT0004799 hsa-miR-589-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004799 hsa-miR-589 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034801 MIMAT0004799 hsa-miR-589-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004799 hsa-miR-589 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034802 MIMAT0004799 hsa-miR-589-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004799 hsa-miR-589 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034803 MIMAT0004799 hsa-miR-589-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004799 hsa-miR-589 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034804 MIMAT0004800 hsa-miR-550a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004800 "hsa-miR-550, hsa-miR-550a " miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00034805 MIMAT0004800 hsa-miR-550a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004800 "hsa-miR-550, hsa-miR-550a " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034806 MIMAT0004800 hsa-miR-550a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004800 "hsa-miR-550, hsa-miR-550a " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034807 MIMAT0004800 hsa-miR-550a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004800 "hsa-miR-550, hsa-miR-550a " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034808 MIMAT0004801 hsa-miR-590-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004801 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034809 MIMAT0004801 hsa-miR-590-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004801 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034810 MIMAT0004801 hsa-miR-590-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004801 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034811 MIMAT0004801 hsa-miR-590-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004801 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034812 MIMAT0004802 hsa-miR-593-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004802 hsa-miR-593 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00034813 MIMAT0004803 hsa-miR-548a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004803 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034814 MIMAT0004804 hsa-miR-615-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004804 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034815 MIMAT0004804 hsa-miR-615-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004804 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034816 MIMAT0004804 hsa-miR-615-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004804 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034817 MIMAT0004804 hsa-miR-615-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004804 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034818 MIMAT0004806 hsa-miR-548c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004806 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034819 MIMAT0004806 hsa-miR-548c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004806 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034820 MIMAT0004806 hsa-miR-548c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004806 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00034821 MIMAT0004808 hsa-miR-625-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004808 hsa-miR-625* miRNA Homo sapiens 22675530 Circulating Serum qRT-PCR Low levels of cell-free circulating miR-361-3p and miR-625* as blood-based markers for discriminating malignant from benign lung tumors. RLID00034822 MIMAT0004808 hsa-miR-625-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004808 hsa-miR-625* miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034823 MIMAT0004808 hsa-miR-625-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004808 hsa-miR-625* miRNA Homo sapiens 21505438 Exosome Primary dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034824 MIMAT0004808 hsa-miR-625-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004808 hsa-miR-625* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034825 MIMAT0004808 hsa-miR-625-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004808 hsa-miR-625* miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00034826 MIMAT0004808 hsa-miR-625-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004808 hsa-miR-625* miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034827 MIMAT0004808 hsa-miR-625-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004808 hsa-miR-625* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034828 MIMAT0004808 hsa-miR-625-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004808 hsa-miR-625* miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034829 MIMAT0004809 hsa-miR-628-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004809 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034830 MIMAT0004809 hsa-miR-628-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004809 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034831 MIMAT0004809 hsa-miR-628-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004809 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034832 MIMAT0004809 hsa-miR-628-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004809 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034833 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034834 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034835 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034836 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00034837 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034838 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034839 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034840 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034841 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034842 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00034843 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034844 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034845 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00034846 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034847 MIMAT0004810 hsa-miR-629-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004810 hsa-miR-629 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034848 MIMAT0004811 hsa-miR-33b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004811 hsa-miR-33b* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034849 MIMAT0004812 hsa-miR-548d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004812 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034850 MIMAT0004813 hsa-miR-411-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004813 hsa-miR-411* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034851 MIMAT0004813 hsa-miR-411-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004813 hsa-miR-411* miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00034852 MIMAT0004813 hsa-miR-411-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004813 hsa-miR-411* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034853 MIMAT0004814 hsa-miR-654-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004814 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034854 MIMAT0004814 hsa-miR-654-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004814 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034855 MIMAT0004814 hsa-miR-654-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0003330 hsa-miR-654 miRNA Homo sapiens 20668554 Microvesicle MSC cell qRT-PCR Table 5: Selectively expressed miRNAs from MSC MVs and their cells of origin. Data are collected from Table 5. RLID00034856 MIMAT0004819 hsa-miR-671-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004819 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00034857 MIMAT0004819 hsa-miR-671-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004819 miRNA Homo sapiens 21505438 Exosome Primary dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034858 MIMAT0004819 hsa-miR-671-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004819 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034859 MIMAT0004819 hsa-miR-671-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004819 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034860 MIMAT0004819 hsa-miR-671-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004819 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034861 MIMAT0004819 hsa-miR-671-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004819 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00034862 MIMAT0004819 hsa-miR-671-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004819 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00034863 MIMAT0004819 hsa-miR-671-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004819 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00034864 MIMAT0004820 mmu-miR-744-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004820 mmu-miR-744* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034865 MIMAT0004821 mmu-miR-671-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004821 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034866 MIMAT0004825 mmu-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004825 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034867 MIMAT0004825 mmu-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004825 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034868 MIMAT0004827 mmu-miR-297b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004827 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034869 MIMAT0004828 mmu-miR-708-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004828 mmu-miR-708 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034870 MIMAT0004857 mmu-miR-147-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004857 mmu-miR-147 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00034871 MIMAT0004859 mmu-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004859 mmu-miR-193b miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034872 MIMAT0004859 mmu-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004859 mmu-miR-193b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034873 MIMAT0004859 mmu-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004859 mmu-miR-193b miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00034874 MIMAT0004859 mmu-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004859 mmu-miR-193b miRNA Mus musculus 21862971 Nucleus Liver cell Microarray "Supplementary information, Figure S4 Screening for the target miRNAs of miR-709 in the nucleus via microarray assay (only top 44 miRNAs were showed). Data are collected from Figure S4. " RLID00034875 MIMAT0004859 mmu-miR-193b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004859 mmu-miR-193b miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034876 MIMAT0004861 mmu-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004861 mmu-miR-877 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034877 MIMAT0004862 mmu-miR-877-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004862 mmu-miR-877* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034878 MIMAT0004862 mmu-miR-877-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004862 mmu-miR-877* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034879 MIMAT0004865 mmu-miR-297c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004865 mmu-miR-297c miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034880 MIMAT0004869 mmu-miR-421-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004869 mmu-miR-421 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034881 MIMAT0004869 mmu-miR-421-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004869 mmu-miR-421 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034882 MIMAT0004871 mmu-miR-465b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004871 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034883 MIMAT0004873 mmu-miR-465c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004873 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034884 MIMAT0004876 mmu-miR-466b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004876 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034885 MIMAT0004878 mmu-miR-466c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004878 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034886 MIMAT0004880 mmu-miR-466e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004880 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034887 MIMAT0004882 mmu-miR-466f-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004882 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034888 MIMAT0004883 mmu-miR-466g http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004883 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034889 MIMAT0004884 mmu-miR-466h-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004884 mmu-miR-466h miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034890 MIMAT0004885 mmu-miR-467c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004885 mmu-miR-467c miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034891 MIMAT0004887 mmu-miR-467d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004887 mmu-miR-467d* miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034892 MIMAT0004889 mmu-miR-504-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004889 mmu-miR-504 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034893 MIMAT0004891 mmu-miR-509-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004891 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034894 MIMAT0004893 mmu-miR-574-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004893 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034895 MIMAT0004894 mmu-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004894 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034896 MIMAT0004894 mmu-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004894 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034897 MIMAT0004894 mmu-miR-574-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004894 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034898 MIMAT0004898 mmu-miR-654-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004898 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034899 MIMAT0004901 hsa-miR-298 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004901 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00034900 MIMAT0004902 hsa-miR-891a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004902 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00034901 MIMAT0004902 hsa-miR-891a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004902 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00034902 MIMAT0004902 hsa-miR-891a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004902 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034903 MIMAT0004909 hsa-miR-450b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004909 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034904 MIMAT0004909 hsa-miR-450b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004909 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034905 MIMAT0004910 hsa-miR-450b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004910 miRNA Homo sapiens 23938262 Circulating Plasma RT-PCR|Microarray "Plasma-based circulating MicroRNA biomarkers for Parkinson's disease. We identified 9 pairs of PD-predictive classifiers using k-TSP analysis and 13 most differentially-expressed miRNAs by SAM. A combination of both data sets produced a panel of PD-predictive biomarkers: k-TSP1 (miR-1826/miR-450b-3p), miR-626, and miR-505, and achieved the highest predictive power of 91% sensitivity, 100% specificity, 100% positive predicted value, and 88% negative predicted value in the replication set. However, low predictive values were shown in the validation set. " RLID00034906 MIMAT0004911 hsa-miR-874-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004911 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034907 MIMAT0004911 hsa-miR-874-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004911 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034908 MIMAT0004911 hsa-miR-874-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004911 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034909 MIMAT0004911 hsa-miR-874-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004911 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034910 MIMAT0004911 hsa-miR-874-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004911 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00034911 MIMAT0004911 hsa-miR-874-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004911 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034912 MIMAT0004911 hsa-miR-874-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004911 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034913 MIMAT0004912 hsa-miR-890 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004912 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00034914 MIMAT0004917 hsa-miR-888-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004917 hsa-miR-888* miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00034915 MIMAT0004917 hsa-miR-888-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004917 hsa-miR-888* miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00034916 MIMAT0004918 hsa-miR-892b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004918 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034917 MIMAT0004918 hsa-miR-892b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004918 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034918 MIMAT0004918 hsa-miR-892b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004918 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00034919 MIMAT0004919 hsa-miR-541-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004919 hsa-miR-541* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034920 MIMAT0004919 hsa-miR-541-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004919 hsa-miR-541* miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00034921 MIMAT0004919 hsa-miR-541-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004919 hsa-miR-541* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034922 MIMAT0004920 hsa-miR-541-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004920 hsa-miR-541 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00034923 MIMAT0004920 hsa-miR-541-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004920 hsa-miR-541 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034924 MIMAT0004920 hsa-miR-541-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004920 hsa-miR-541 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034925 MIMAT0004921 hsa-miR-889-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004921 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034926 MIMAT0004924 hsa-miR-876-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004924 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034927 MIMAT0004925 hsa-miR-876-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004925 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034928 MIMAT0004926 hsa-miR-708-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004926 hsa-miR-708 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034929 MIMAT0004926 hsa-miR-708-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004926 hsa-miR-708 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034930 MIMAT0004926 hsa-miR-708-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004926 hsa-miR-708 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034931 MIMAT0004926 hsa-miR-708-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004926 hsa-miR-708 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00034932 MIMAT0004927 hsa-miR-708-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004927 hsa-miR-708* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034933 MIMAT0004927 hsa-miR-708-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004927 hsa-miR-708* miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00034934 MIMAT0004929 hsa-miR-190b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004929 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034935 MIMAT0004931 mmu-miR-466d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004931 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00034936 MIMAT0004933 mmu-miR-878-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004933 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034937 MIMAT0004934 mmu-miR-872-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004934 mmu-miR-872 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034938 MIMAT0004937 mmu-miR-875-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004937 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034939 MIMAT0004940 mmu-miR-511-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004940 mmu-miR-511 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00034940 MIMAT0004941 mmu-miR-544-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004941 mmu-miR-544 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034941 MIMAT0004942 mmu-miR-598-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004942 mmu-miR-598 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00034942 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034943 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034944 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034945 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00034946 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00034947 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034948 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00034949 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034950 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00034951 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00034952 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00034953 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034954 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034955 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034956 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034957 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034958 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034959 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034960 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034961 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00034962 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00034963 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034964 MIMAT0004945 hsa-miR-744-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004945 hsa-miR-744 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00034965 MIMAT0004946 hsa-miR-744-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004946 hsa-miR-744* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034966 MIMAT0004946 hsa-miR-744-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004946 hsa-miR-744* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034967 MIMAT0004946 hsa-miR-744-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004946 hsa-miR-744* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034968 MIMAT0004947 hsa-miR-885-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004947 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00034969 MIMAT0004947 hsa-miR-885-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004947 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034970 MIMAT0004947 hsa-miR-885-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004947 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034971 MIMAT0004947 hsa-miR-885-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004947 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00034972 MIMAT0004947 hsa-miR-885-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004947 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034973 MIMAT0004947 hsa-miR-885-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004947 miRNA Homo sapiens 24577456 Circulating Serum Next-generation sequencing The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. Table 2 has displayed the data. RLID00034974 MIMAT0004948 hsa-miR-885-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004948 miRNA Homo sapiens 19597549 Circulating Serum Microarray "In a comparison of stages 3 and 4 prostate cancer sera and normal donor serum miRNA levels, we found that 15 miRNAs (miR-16, -92a, -103, -107, -197, -34b, -328, -485-3p, -486-5p, -92b, -574-3p, -636, -640, -766, -885-5p) were up-regulated in serum from prostate cancer patients compared to normal donor sera. " RLID00034975 MIMAT0004948 hsa-miR-885-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004948 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034976 MIMAT0004948 hsa-miR-885-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004948 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00034977 MIMAT0004948 hsa-miR-885-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004948 miRNA Homo sapiens 24373621 Circulating Plasma qRT-PCR "Unsupervised clustering of the expression profiles using the six most regulated miRNAs (miR-425-5p, miR-21-5p, miR-106b-5p, miR-590-5p, miR-574-3p, miR-885-3p) significantly (p = 0.012) separated plasma samples collected prior to treatment from plasma samples collected after two days of radiochemotherapy. " RLID00034978 MIMAT0004948 hsa-miR-885-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004948 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034979 MIMAT0004948 hsa-miR-885-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004948 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034980 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00034981 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00034982 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034983 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00034984 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034985 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034986 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00034987 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00034988 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00034989 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034990 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00034991 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00034992 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00034993 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034994 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00034995 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00034996 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00034997 MIMAT0004949 hsa-miR-877-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004949 hsa-miR-877 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00034998 MIMAT0004950 hsa-miR-877-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004950 hsa-miR-877* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00034999 MIMAT0004950 hsa-miR-877-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004950 hsa-miR-877* miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00035000 MIMAT0004951 hsa-miR-887-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004951 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035001 MIMAT0004951 hsa-miR-887-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004951 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035002 MIMAT0004952 hsa-miR-665 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004952 miRNA Homo sapiens 21505438 Exosome Primary dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035003 MIMAT0004952 hsa-miR-665 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004952 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035004 MIMAT0004952 hsa-miR-665 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004952 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035005 MIMAT0004952 hsa-miR-665 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004952 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00035006 MIMAT0004952 hsa-miR-665 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004952 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00035007 MIMAT0004953 hsa-miR-873-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004953 hsa-miR-873 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035008 MIMAT0004953 hsa-miR-873-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004953 hsa-miR-873 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035009 MIMAT0004953 hsa-miR-873-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004953 hsa-miR-873 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035010 MIMAT0004953 hsa-miR-873-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004953 hsa-miR-873 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035011 MIMAT0004953 hsa-miR-873-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004953 hsa-miR-873 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00035012 MIMAT0004953 hsa-miR-873-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004953 hsa-miR-873 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00035013 MIMAT0004953 hsa-miR-873-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004953 hsa-miR-873 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00035014 MIMAT0004954 hsa-miR-543 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004954 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035015 MIMAT0004954 hsa-miR-543 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004954 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00035016 MIMAT0004954 hsa-miR-543 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004954 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035017 MIMAT0004954 hsa-miR-543 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004954 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035018 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035019 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035020 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00035021 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035022 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035023 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00035024 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035025 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035026 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035027 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00035028 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035029 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00035030 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00035031 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035032 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035033 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00035034 MIMAT0004955 hsa-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004955 hsa-miR-374b miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00035035 MIMAT0004957 hsa-miR-760 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004957 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035036 MIMAT0004957 hsa-miR-760 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004957 miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00035037 MIMAT0004957 hsa-miR-760 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004957 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035038 MIMAT0004957 hsa-miR-760 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004957 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035039 MIMAT0004957 hsa-miR-760 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004957 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035040 MIMAT0004957 hsa-miR-760 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004957 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00035041 MIMAT0004957 hsa-miR-760 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004957 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035042 MIMAT0004957 hsa-miR-760 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004957 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035043 MIMAT0004957 hsa-miR-760 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004957 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035044 MIMAT0004957 hsa-miR-760 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004957 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00035045 MIMAT0004957 hsa-miR-760 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004957 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00035046 MIMAT0004958 hsa-miR-301b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004958 hsa-miR-301b miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00035047 MIMAT0004958 hsa-miR-301b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004958 hsa-miR-301b miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035048 MIMAT0004958 hsa-miR-301b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004958 hsa-miR-301b miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035049 MIMAT0004958 hsa-miR-301b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004958 hsa-miR-301b miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035050 MIMAT0004959 hsa-miR-216b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004959 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035051 MIMAT0004959 hsa-miR-216b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004959 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035052 MIMAT0004960 hsa-miR-208b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004960 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035053 MIMAT0004971 hsa-miR-921 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004971 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035054 MIMAT0004971 hsa-miR-921 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004971 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035055 MIMAT0004976 hsa-miR-933 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004976 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035056 MIMAT0004976 hsa-miR-933 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004976 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035057 MIMAT0004978 hsa-miR-935 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004978 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00035058 MIMAT0004978 hsa-miR-935 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004978 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035059 MIMAT0004978 hsa-miR-935 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004978 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035060 MIMAT0004978 hsa-miR-935 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004978 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035061 MIMAT0004978 hsa-miR-935 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004978 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035062 MIMAT0004979 hsa-miR-936 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004979 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035063 MIMAT0004979 hsa-miR-936 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004979 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035064 MIMAT0004980 hsa-miR-937-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004980 hsa-miR-937 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035065 MIMAT0004980 hsa-miR-937-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004980 hsa-miR-937 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00035066 MIMAT0004982 hsa-miR-939-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004982 hsa-miR-939 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035067 MIMAT0004982 hsa-miR-939-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004982 hsa-miR-939 miRNA Homo sapiens 22997154 Circulating Plasma Microarray "Co-transfection with HBV replicative constructs suggested that let-7f, miR-939 and miR-638 can modulate HBV replication. Therefore, we propose that the miRNA profile constitutes a novel circulating marker that can help to predict response to IFN treatment in CHB patients. " RLID00035068 MIMAT0004982 hsa-miR-939-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004982 hsa-miR-939 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035069 MIMAT0004982 hsa-miR-939-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004982 hsa-miR-939 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035070 MIMAT0004983 hsa-miR-940 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004983 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035071 MIMAT0004983 hsa-miR-940 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004983 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035072 MIMAT0004983 hsa-miR-940 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004983 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00035073 MIMAT0004983 hsa-miR-940 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004983 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00035074 MIMAT0004983 hsa-miR-940 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004983 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035075 MIMAT0004983 hsa-miR-940 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004983 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035076 MIMAT0004983 hsa-miR-940 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004983 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035077 MIMAT0004983 hsa-miR-940 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004983 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035078 MIMAT0004983 hsa-miR-940 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004983 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00035079 MIMAT0004984 hsa-miR-941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004984 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035080 MIMAT0004984 hsa-miR-941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004984 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035081 MIMAT0004984 hsa-miR-941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004984 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035082 MIMAT0004984 hsa-miR-941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004984 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035083 MIMAT0004984 hsa-miR-941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004984 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00035084 MIMAT0004984 hsa-miR-941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004984 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035085 MIMAT0004984 hsa-miR-941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004984 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035086 MIMAT0004984 hsa-miR-941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004984 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035087 MIMAT0004984 hsa-miR-941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004984 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035088 MIMAT0004984 hsa-miR-941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004984 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035089 MIMAT0004984 hsa-miR-941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004984 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035090 MIMAT0004985 hsa-miR-942-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004985 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035091 MIMAT0004985 hsa-miR-942-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004985 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035092 MIMAT0004985 hsa-miR-942-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004985 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035093 MIMAT0004985 hsa-miR-942-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004985 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035094 MIMAT0004985 hsa-miR-942-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004985 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035095 MIMAT0004986 hsa-miR-943 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004986 miRNA Homo sapiens 20145944 Circulating Semen RT-PCR|Microarray "Our results highlight four miRNA markers for blood identification (miR-20a, miR-106a, miR-185, and miR-144) and five for semen identification (miR-135a, miR-10a, miR-507, miR-943, and miR-891a). Of those, two miRNA markers for blood (miR-144 and miR-185) and two others for semen (miR-135a and miR-897a) are suggestive to be most useful for body fluid identification in future forensic applications, and the respective RT-PCR assays used here for their detection were highly sensitive, allowing the reliable marker detection from subpicogram amounts of total RNA. Our results proved the applicability of the miRNA approach for forensic body fluids identification. " RLID00035096 MIMAT0004986 hsa-miR-943 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004986 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035097 MIMAT0004986 hsa-miR-943 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004986 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00035098 MIMAT0004986 hsa-miR-943 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004986 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00035099 MIMAT0004986 hsa-miR-943 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004986 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00035100 MIMAT0004987 hsa-miR-944 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004987 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035101 MIMAT0004987 hsa-miR-944 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0004987 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035102 MIMAT0005202 ppt-miR1073-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005202 miRNA Physcomitrella patens 23749811 Chloroplast Protonemata RT-PCR "From analysis of P. patens microRNA, miR1073 was predicted to target CuZn-SOD mRNAs. We noticed that two chloroplastic CuZn-SOD genes contain the miR1073 target sequence in the 3¡ä untranslated region; however, the cytosolic isozyme genes lack this sequence. In this study, we investigated the involvement of miR1073 in the expression of CuZn-SOD genes in P. patens. When protonemata of P. patens were cultured on a copper-depleted medium, SOD activity and mRNA levels of chloroplastic CuZn-SODs were decreased markedly. In contrast, cytosolic CuZn-SODs showed little or no change in mRNA levels or SOD activity. The precursor transcript and the mature form of miR1073 were induced by copper deficiency. The chloroplastic CuZn-SOD (PpCSD1) mRNA was cleaved at the miR1073 target site under copper deficiency. These results suggest that miR1073 is involved in the down-regulation of PpCSD1 expression. " RLID00035103 MIMAT0005203 ppt-miR1073-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005203 miRNA Physcomitrella patens 23749811 Chloroplast Protonemata RT-PCR "From analysis of P. patens microRNA, miR1073 was predicted to target CuZn-SOD mRNAs. We noticed that two chloroplastic CuZn-SOD genes contain the miR1073 target sequence in the 3¡ä untranslated region; however, the cytosolic isozyme genes lack this sequence. In this study, we investigated the involvement of miR1073 in the expression of CuZn-SOD genes in P. patens. When protonemata of P. patens were cultured on a copper-depleted medium, SOD activity and mRNA levels of chloroplastic CuZn-SODs were decreased markedly. In contrast, cytosolic CuZn-SODs showed little or no change in mRNA levels or SOD activity. The precursor transcript and the mature form of miR1073 were induced by copper deficiency. The chloroplastic CuZn-SOD (PpCSD1) mRNA was cleaved at the miR1073 target site under copper deficiency. These results suggest that miR1073 is involved in the down-regulation of PpCSD1 expression. " RLID00035104 MIMAT0005279 rno-miR-466c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005279 rno-miR-466c miRNA Rattus norvegicus 25297646 Circulating Plasma qRT-PCR|Microarray "In plasma, miRNA upregulation was observed for miR-133a and miR-133b following PH and SL, whereas miR-100 and miR-466c were similarly downregulated following anesthesia and surgery. " RLID00035105 MIMAT0005284 rno-miR-874-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005284 rno-miR-874 miRNA Rattus norvegicus 24324399 Nucleus Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035106 MIMAT0005284 rno-miR-874-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005284 rno-miR-874 miRNA Rattus norvegicus 24553149 Circulating Plasma qRT-PCR|Microarray "Microarray assay results showed a total of 36 differentially-expressed miRNAs, among which 15 miRNAs were considered as aberrantly expressed with a more than 2-fold change when calculating the ratio of fluorescence intense between the 2 groups. The elevated miRNAs included miR-290, miR-874, miR-292-5p, miR-327, miR-374, miR-98, miR-352, miR-132, miR-146b, and miR-196a. The down-regulated miRNAs included miR-145, miR-329, miR-375, miR-140*, and miR-29a. Validation of microarray assay by qRT-PCR showed similar results and the ΔΔCt value compared to the sham group are shown in Figure 1. " RLID00035107 MIMAT0005290 rno-miR-883-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005290 rno-miR-883 miRNA Rattus norvegicus 22518031 Mitochondrion Heart qRT-PCR "We validated our microarray data using qPCR. 12S rRNA, a mitochondrial gene product 1, served as our internal control. We confirmed that miR-181c was predominantly localized to the mitochondrial fraction; its expression in the mitochondrial fraction was similar to that in the total heart fraction (Fig. 2A). In addition, fluorescence in situ hybridization (FISH) (Fig. 2C) shows co-localization of miR-181c with the mitochondrial marker, mitoTracker red. We also examined miR-181c expression in both cytosolic and mitochondrial fractions (Fig. 2B, left panel), using qPCR and found that miR-181c was enriched primarily in the mitochondrial fraction. We evaluated several other miRNAs as negative controls for mitochondrial localization, and miR-1192 data are included in Fig. 2B (right panel). We used 5S rRNA as an internal control for these sets of qPCR data, as it is known that this gene is present in both the cytosol and mitochondrial fractions 18. Data are collected from Figure 2. " RLID00035108 MIMAT0005291 mmu-miR-582-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005291 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00035109 MIMAT0005293 mmu-miR-467e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005293 mmu-miR-467e miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00035110 MIMAT0005300 rno-miR-182 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005300 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035111 MIMAT0005302 rno-miR-190b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005302 rno-miR-190b miRNA Rattus norvegicus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00035112 MIMAT0005303 rno-miR-196c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005303 rno-miR-196c miRNA Rattus norvegicus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00035113 MIMAT0005307 rno-miR-375-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005307 rno-miR-375 miRNA Rattus norvegicus 24553149 Circulating Plasma qRT-PCR|Microarray "Microarray assay results showed a total of 36 differentially-expressed miRNAs, among which 15 miRNAs were considered as aberrantly expressed with a more than 2-fold change when calculating the ratio of fluorescence intense between the 2 groups. The elevated miRNAs included miR-290, miR-874, miR-292-5p, miR-327, miR-374, miR-98, miR-352, miR-132, miR-146b, and miR-196a. The down-regulated miRNAs included miR-145, miR-329, miR-375, miR-140*, and miR-29a. Validation of microarray assay by qRT-PCR showed similar results and the ΔΔCt value compared to the sham group are shown in Figure 1. " RLID00035114 MIMAT0005309 rno-miR-384-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005309 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035115 MIMAT0005312 rno-miR-411-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005312 rno-miR-411 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035116 MIMAT0005314 rno-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005314 rno-miR-425 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00035117 MIMAT0005314 rno-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005314 rno-miR-425 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035118 MIMAT0005315 rno-miR-434-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005315 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035119 MIMAT0005315 rno-miR-434-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005315 miRNA Rattus norvegicus 19628621 Nucleolus Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00035120 MIMAT0005319 rno-miR-484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005319 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035121 MIMAT0005321 rno-miR-500-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005321 rno-miR-500 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035122 MIMAT0005321 rno-miR-500-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005321 rno-miR-500 miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00035123 MIMAT0005322 rno-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005322 miRNA Rattus norvegicus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00035124 MIMAT0005322 rno-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005322 miRNA Rattus norvegicus 25562527 Mitochondrion Hippocampus qRT-PCR "The levels of several mitochondria-associated miRNAs were found to increase following TBI. Among them, miR-155 and miR-223 levels were significantly elevated to 7.3 and 4.63 fold higher, respectively, in mitochondria fractions of injured relative to na?ve (uninjured) rats (Table 1). Data are collected from Table 1: Changes in mitochondria-associated and cytosolic miRNAs at 12 hr following TBI. " RLID00035125 MIMAT0005323 rno-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005323 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035126 MIMAT0005324 rno-miR-598-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005324 miRNA Rattus norvegicus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00035127 MIMAT0005325 rno-miR-598-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005325 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035128 MIMAT0005326 rno-miR-671 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005326 miRNA Rattus norvegicus 19106625 Mitochondrion Liver cell qRT-PCR|Microarray "We used a custom miRNA microarray system to survey miRNA expression at a genome-wide scale in the isolated mitochondria. The array had probes derived from rat (rno), mouse (mmu), or human (hsa) miRNAs. Using this array, 15 miRNA probes were identified that yielded signals significantly above background in each of the mitochondrial fractions and were also present following RNase treatment of the purified structures (Table 1). Data are collected from Table 1: miRNAs identified in RNA isolated from purified rat liver mitochondria " RLID00035129 MIMAT0005331 rno-miR-708-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005331 rno-miR-708 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035130 MIMAT0005340 rno-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005340 rno-miR-92b miRNA Rattus norvegicus 24324399 Nucleus Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035131 MIMAT0005439 mmu-let-7c-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005439 mmu-let-7c-2* miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00035132 MIMAT0005440 mmu-miR-24-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005440 mmu-miR-24-2* miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00035133 MIMAT0005441 rno-miR-24-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005441 rno-miR-24-2* miRNA Rattus norvegicus 19628621 Cytoplasm Myoblast Microarray "Supplementary Table 1: This table contains data from a miRNA expression matrix for nucleolar (NO), nucleoplasmic (NU) and cytoplasmic (CY) fractions from L6 myoblasts. Data are collected from Table S1. " RLID00035134 MIMAT0005442 rno-miR-30c-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005442 rno-miR-30c-2* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035135 MIMAT0005449 hsa-miR-523-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005449 hsa-miR-523* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00035136 MIMAT0005450 hsa-miR-518e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005450 hsa-miR-518e* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035137 MIMAT0005450 hsa-miR-518e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005450 hsa-miR-518e* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00035138 MIMAT0005451 hsa-miR-522-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005451 hsa-miR-522* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00035139 MIMAT0005452 hsa-miR-519a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005452 hsa-miR-519a* miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00035140 MIMAT0005454 hsa-miR-519b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005454 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00035141 MIMAT0005454 hsa-miR-519b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005454 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00035142 MIMAT0005455 hsa-miR-520c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005455 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00035143 MIMAT0005456 hsa-miR-518d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005456 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00035144 MIMAT0005457 hsa-miR-518a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005457 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00035145 MIMAT0005457 hsa-miR-518a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005457 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00035146 MIMAT0005458 hsa-miR-1224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005458 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035147 MIMAT0005458 hsa-miR-1224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005458 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035148 MIMAT0005458 hsa-miR-1224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005458 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035149 MIMAT0005458 hsa-miR-1224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005458 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035150 MIMAT0005458 hsa-miR-1224-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005458 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00035151 MIMAT0005459 hsa-miR-1224-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005459 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035152 MIMAT0005572 hsa-miR-1225-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005572 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035153 MIMAT0005572 hsa-miR-1225-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005572 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035154 MIMAT0005573 hsa-miR-1225-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005573 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035155 MIMAT0005576 hsa-miR-1226-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005576 hsa-miR-1226* miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035156 MIMAT0005576 hsa-miR-1226-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005576 hsa-miR-1226* miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035157 MIMAT0005576 hsa-miR-1226-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005576 hsa-miR-1226* miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00035158 MIMAT0005577 hsa-miR-1226-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005577 hsa-miR-1226 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035159 MIMAT0005580 hsa-miR-1227-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005580 hsa-miR-1227 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035160 MIMAT0005580 hsa-miR-1227-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005580 hsa-miR-1227 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00035161 MIMAT0005580 hsa-miR-1227-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005580 hsa-miR-1227 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035162 MIMAT0005580 hsa-miR-1227-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005580 hsa-miR-1227 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035163 MIMAT0005582 hsa-miR-1228-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005582 hsa-miR-1228* miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00035164 MIMAT0005582 hsa-miR-1228-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005582 hsa-miR-1228* miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00035165 MIMAT0005582 hsa-miR-1228-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005582 hsa-miR-1228* miRNA Homo sapiens 25238238 Circulating Serum qRT-PCR "Our study revealed that serum hsa-miR-206, hsa-miR-141-3p, hsa-miR-433-3p, hsa-miR-1228-5p, hsa-miR-199a-5p, hsa-miR-122-5p, hsa-miR-192-5p, and hsa-miR-26a-5p were potential circulating markers for HCC diagnosis. " RLID00035166 MIMAT0005582 hsa-miR-1228-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005582 hsa-miR-1228* miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035167 MIMAT0005582 hsa-miR-1228-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005582 hsa-miR-1228* miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00035168 MIMAT0005583 hsa-miR-1228-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005583 hsa-miR-1228 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035169 MIMAT0005583 hsa-miR-1228-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005583 hsa-miR-1228 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035170 MIMAT0005583 hsa-miR-1228-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005583 hsa-miR-1228 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035171 MIMAT0005583 hsa-miR-1228-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005583 hsa-miR-1228 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00035172 MIMAT0005584 hsa-miR-1229-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005584 hsa-miR-1229 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035173 MIMAT0005584 hsa-miR-1229-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005584 hsa-miR-1229 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035174 MIMAT0005584 hsa-miR-1229-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005584 hsa-miR-1229 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035175 MIMAT0005584 hsa-miR-1229-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005584 hsa-miR-1229 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035176 MIMAT0005586 hsa-miR-1231 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005586 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035177 MIMAT0005588 hsa-miR-1233-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005588 hsa-miR-1233 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035178 MIMAT0005588 hsa-miR-1233-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005588 hsa-miR-1233 miRNA Homo sapiens 25017274 Circulating Serum qRT-PCR "The expression of four miRNAs (miR-1233, miR-520, miR-210, miR-144) was validated by quantitative real-time polymerase chain reaction analysis. MiR-1233 was the most overexpressed in the serum of women who later developed sPE. Circulating miRNAs deserve further investigation in order to explore their potential role in the pathogenesis of preeclampsia. In particular, miR-1233 might represent a potential marker of early sPE. " RLID00035179 MIMAT0005589 hsa-miR-1234-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005589 hsa-miR-1234 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035180 MIMAT0005589 hsa-miR-1234-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005589 hsa-miR-1234 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035181 MIMAT0005589 hsa-miR-1234-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005589 hsa-miR-1234 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00035182 MIMAT0005589 hsa-miR-1234-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005589 hsa-miR-1234 miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00035183 MIMAT0005591 hsa-miR-1236-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005591 hsa-miR-1236 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035184 MIMAT0005591 hsa-miR-1236-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005591 hsa-miR-1236 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035185 MIMAT0005592 hsa-miR-1237-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005592 hsa-miR-1237 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035186 MIMAT0005592 hsa-miR-1237-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005592 hsa-miR-1237 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035187 MIMAT0005593 hsa-miR-1238-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005593 hsa-miR-1238 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035188 MIMAT0005593 hsa-miR-1238-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005593 hsa-miR-1238 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035189 MIMAT0005593 hsa-miR-1238-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005593 hsa-miR-1238 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00035190 MIMAT0005595 rno-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005595 rno-miR-146b miRNA Rattus norvegicus 21435393 Microvesicle Serum RT-PCR "By using RT-PCR and specific forward/reverse primers these microRNAs were all detected in microvesicles, that had been released from primary and differentiated rat adipocytes after 6 and 24h incubation, respectively, as well as in microvesicles from rat serum(Fig. 6; shown only for miR-16, miR-27a, miR-146b and miR-222). " RLID00035191 MIMAT0005595 rno-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005595 rno-miR-146b miRNA Rattus norvegicus 24553149 Circulating Plasma qRT-PCR|Microarray "Microarray assay results showed a total of 36 differentially-expressed miRNAs, among which 15 miRNAs were considered as aberrantly expressed with a more than 2-fold change when calculating the ratio of fluorescence intense between the 2 groups. The elevated miRNAs included miR-290, miR-874, miR-292-5p, miR-327, miR-374, miR-98, miR-352, miR-132, miR-146b, and miR-196a. The down-regulated miRNAs included miR-145, miR-329, miR-375, miR-140*, and miR-29a. Validation of microarray assay by qRT-PCR showed similar results and the ΔΔCt value compared to the sham group are shown in Figure 1. " RLID00035192 MIMAT0005595 rno-miR-146b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005595 rno-miR-146b miRNA Rattus norvegicus 22529849 Exosome Adipocytes - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00035193 MIMAT0005596 rno-miR-551b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005596 rno-miR-551b miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035194 MIMAT0005788 hsa-miR-513b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005788 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035195 MIMAT0005789 hsa-miR-513c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005789 hsa-miR-513c miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035196 MIMAT0005789 hsa-miR-513c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005789 hsa-miR-513c miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035197 MIMAT0005790 osa-miR444a-3p.2 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005790 osa-miR444a.2 miRNA Oryza sativa 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035198 MIMAT0005791 hsa-miR-1264 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005791 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035199 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035200 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035201 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035202 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00035203 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035204 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00035205 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035206 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00035207 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035208 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00035209 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00035210 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00035211 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035212 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035213 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035214 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035215 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00035216 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00035217 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035218 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035219 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00035220 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00035221 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00035222 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 24627568 Circulating Plasma qRT-PCR "The plasma levels of miR-320b and miR-125b were significantly lower in patients with AMI when compared with controls, and these miRNAs may be involved in the pathogenesis of coronary heart disease. " RLID00035223 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00035224 MIMAT0005792 hsa-miR-320b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005792 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00035225 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035226 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035227 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035228 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00035229 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035230 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00035231 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035232 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00035233 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035234 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035235 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035236 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035237 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035238 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00035239 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035240 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035241 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00035242 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00035243 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00035244 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 22529849 Exosome Ovarian - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00035245 MIMAT0005793 hsa-miR-320c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005793 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00035246 MIMAT0005794 hsa-miR-1296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005794 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035247 MIMAT0005794 hsa-miR-1296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005794 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035248 MIMAT0005794 hsa-miR-1296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005794 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00035249 MIMAT0005794 hsa-miR-1296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005794 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035250 MIMAT0005795 hsa-miR-1323 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005795 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035251 MIMAT0005795 hsa-miR-1323 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005795 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00035252 MIMAT0005796 hsa-miR-1271-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005796 hsa-miR-1271 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035253 MIMAT0005796 hsa-miR-1271-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005796 hsa-miR-1271 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00035254 MIMAT0005796 hsa-miR-1271-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005796 hsa-miR-1271 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035255 MIMAT0005796 hsa-miR-1271-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005796 hsa-miR-1271 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00035256 MIMAT0005797 hsa-miR-1301-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005797 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035257 MIMAT0005797 hsa-miR-1301-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005797 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035258 MIMAT0005797 hsa-miR-1301-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005797 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035259 MIMAT0005797 hsa-miR-1301-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005797 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035260 MIMAT0005800 hsa-miR-1298-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005800 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035261 MIMAT0005800 hsa-miR-1298-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005800 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035262 MIMAT0005800 hsa-miR-1298-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005800 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00035263 MIMAT0005823 hsa-miR-1178-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005823 hsa-miR-1178 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035264 MIMAT0005825 hsa-miR-1180-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005825 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035265 MIMAT0005825 hsa-miR-1180-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005825 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035266 MIMAT0005825 hsa-miR-1180-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005825 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035267 MIMAT0005825 hsa-miR-1180-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005825 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035268 MIMAT0005825 hsa-miR-1180-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005825 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035269 MIMAT0005825 hsa-miR-1180-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005825 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035270 MIMAT0005834 mmu-miR-466i-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005834 mmu-miR-466i miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00035271 MIMAT0005837 mmu-miR-1187 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005837 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00035272 MIMAT0005839 mmu-miR-669f-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005839 mmu-miR-669f miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00035273 MIMAT0005844 mmu-miR-466f http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005844 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00035274 MIMAT0005846 mmu-miR-467f http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005846 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00035275 MIMAT0005846 mmu-miR-467f http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005846 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00035276 MIMAT0005855 mmu-miR-467h http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005855 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00035277 MIMAT0005856 mmu-miR-1195 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005856 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00035278 MIMAT0005859 mmu-miR-1198-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005859 mmu-miR-1198 miRNA Mus musculus 22031862 Exosome Dendritic cell Microarray "Figure 1: miRNA in BMDC-derived immature and mature exosomes. (A) Western blot analysis (top) of 1-mL density fractions from a continuous sucrose gradient used to purify BMDC exosomes. Exosomes, detected by their CD9 expression, were enriched in those fractions with characteristic exosome density. The digital gel (bottom), obtained with Agilent 2100 Bioanalyzer, shows the presence of miRNAs in the density fractions in which exosomes were present. One of 2 experiments is shown. (B) Digital gel (Agilent 2100 Bioanalyzer) showing the presence of similar levels of miRNAs isolated from exosomes treated (or not) with proteinase K and then incubated (or not) with RNase A. Results are representative of 2 independent experiments. (C) Analysis of miRNAs from BMDC exosomes showing intensity of expression of miRNAs against their rank position. Signals above the 2500 cutoff were considered positive. (D) Venn diagram with the numbers of miRNAs detected in immature and mature exosomes released by BMDCs. List with the miRNAs detected by Illumina miRNA Expression Array. In those cases were the probe did not resolve miRNAs differing at only 1 or 2 positions, miRNAs were listed in parentheses. Results are based on the miRNA profiling of 4 different samples of each type of exosomes. Data are collected from Figure 1. " RLID00035279 MIMAT0005859 mmu-miR-1198-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005859 mmu-miR-1198 miRNA Mus musculus 25159140 Exosome Bone marrow Macrophage qRT-PCR "We profiled the miRNA transcriptome of BMDMs and their exo-macs, either UT (n = 3) or IL-4 treated (IL-4; n = 3), by low-density quantitative PCR (qPCR) arrays. A total of 178 (29%) of the 618 miRNAs present in the arrays were detected in at least two out of three biological replicates of both BMDMs and exo-macs (Table S1). " RLID00035280 MIMAT0005863 hsa-miR-1200 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005863 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035281 MIMAT0005865 hsa-miR-1202 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005865 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00035282 MIMAT0005865 hsa-miR-1202 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005865 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035283 MIMAT0005865 hsa-miR-1202 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005865 miRNA Homo sapiens 24961598 Circulating Plasma qRT-PCR "This is the first report of circulating miR biomarkers in LVAD patients. We demonstrate the feasibility of this approach, report the potential for miR-483-3p and miR-1202, respectively, to monitor and predict response to LVAD therapy, and propose further work to study these hypotheses and elucidate roles for miR-483-3p and miR-1202 in clinical practice and in underlying biological processes. " RLID00035284 MIMAT0005866 hsa-miR-1203 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005866 miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00035285 MIMAT0005866 hsa-miR-1203 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005866 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00035286 MIMAT0005867 hsa-miR-663b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005867 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00035287 MIMAT0005867 hsa-miR-663b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005867 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00035288 MIMAT0005868 hsa-miR-1204 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005868 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035289 MIMAT0005874 hsa-miR-548e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005874 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035290 MIMAT0005874 hsa-miR-548e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005874 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035291 MIMAT0005874 hsa-miR-548e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005874 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035292 MIMAT0005875 hsa-miR-548j-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005875 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035293 MIMAT0005875 hsa-miR-548j-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005875 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035294 MIMAT0005876 hsa-miR-1285-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005876 hsa-miR-1285 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035295 MIMAT0005876 hsa-miR-1285-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005876 hsa-miR-1285 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035296 MIMAT0005876 hsa-miR-1285-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005876 hsa-miR-1285 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035297 MIMAT0005876 hsa-miR-1285-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005876 hsa-miR-1285 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035298 MIMAT0005876 hsa-miR-1285-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005876 hsa-miR-1285 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035299 MIMAT0005876 hsa-miR-1285-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005876 hsa-miR-1285 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035300 MIMAT0005876 hsa-miR-1285-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005876 hsa-miR-1285 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00035301 MIMAT0005876 hsa-miR-1285-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005876 hsa-miR-1285 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00035302 MIMAT0005878 hsa-miR-1287-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005878 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035303 MIMAT0005878 hsa-miR-1287-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005878 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035304 MIMAT0005878 hsa-miR-1287-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005878 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035305 MIMAT0005878 hsa-miR-1287-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005878 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035306 MIMAT0005878 hsa-miR-1287-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005878 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035307 MIMAT0005878 hsa-miR-1287-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005878 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035308 MIMAT0005880 hsa-miR-1290 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005880 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00035309 MIMAT0005880 hsa-miR-1290 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005880 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035310 MIMAT0005880 hsa-miR-1290 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005880 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00035311 MIMAT0005880 hsa-miR-1290 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005880 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00035312 MIMAT0005881 hsa-miR-1291 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005881 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00035313 MIMAT0005881 hsa-miR-1291 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005881 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035314 MIMAT0005881 hsa-miR-1291 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005881 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035315 MIMAT0005882 hsa-miR-548k http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005882 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035316 MIMAT0005882 hsa-miR-548k http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005882 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035317 MIMAT0005882 hsa-miR-548k http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005882 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035318 MIMAT0005883 hsa-miR-1293 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005883 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035319 MIMAT0005883 hsa-miR-1293 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005883 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035320 MIMAT0005883 hsa-miR-1293 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005883 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035321 MIMAT0005883 hsa-miR-1293 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005883 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035322 MIMAT0005883 hsa-miR-1293 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005883 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035323 MIMAT0005884 hsa-miR-1294 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005884 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035324 MIMAT0005884 hsa-miR-1294 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005884 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035325 MIMAT0005884 hsa-miR-1294 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005884 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00035326 MIMAT0005887 hsa-miR-1299 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005887 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00035327 MIMAT0005889 hsa-miR-548l http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005889 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035328 MIMAT0005889 hsa-miR-548l http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005889 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00035329 MIMAT0005892 hsa-miR-1304-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005892 hsa-miR-1304 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035330 MIMAT0005892 hsa-miR-1304-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005892 hsa-miR-1304 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035331 MIMAT0005892 hsa-miR-1304-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005892 hsa-miR-1304 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035332 MIMAT0005892 hsa-miR-1304-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005892 hsa-miR-1304 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00035333 MIMAT0005893 hsa-miR-1305 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005893 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00035334 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035335 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035336 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 1: Ten miRNAs differentially expressed in both tumor tissue and serum. Data are collected from Table 1. RLID00035337 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00035338 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00035339 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035340 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 23169280 Circulating Serum Microarray "Table 2 miRNAs detected in pooled patient and control samples, as detected by Agilent Human miRNA microarrays. All of these showed potential as biomarkers as the levels of miRNAs varied between the patient and control groups. The expression levels of six of these miRNAs (in bold) were verified using TaqMan qRT–PCR. Three miRNAs (miR-720, miR-1246 and miR-1308) chosen for further analysis in individual patient samples. TaqMan qRT–PCR assays for the remaining three miRNAs were not available or were unreliable. Data are collected from Table 2. " RLID00035341 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035342 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00035343 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035344 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035345 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035346 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00035347 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00035348 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035349 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray|RT-PCR "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00035350 MIMAT0005898 hsa-miR-1246 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005898 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00035351 MIMAT0005899 hsa-miR-1247-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005899 hsa-miR-1247 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00035352 MIMAT0005899 hsa-miR-1247-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005899 hsa-miR-1247 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035353 MIMAT0005899 hsa-miR-1247-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005899 hsa-miR-1247 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00035354 MIMAT0005899 hsa-miR-1247-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005899 hsa-miR-1247 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035355 MIMAT0005900 hsa-miR-1248 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005900 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00035356 MIMAT0005901 hsa-miR-1249-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005901 hsa-miR-1249 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035357 MIMAT0005901 hsa-miR-1249-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005901 hsa-miR-1249 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00035358 MIMAT0005901 hsa-miR-1249-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005901 hsa-miR-1249 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035359 MIMAT0005902 hsa-miR-1250-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005902 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035360 MIMAT0005902 hsa-miR-1250-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005902 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035361 MIMAT0005902 hsa-miR-1250-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005902 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00035362 MIMAT0005903 hsa-miR-1251-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005903 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035363 MIMAT0005905 hsa-miR-1254 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005905 miRNA Homo sapiens 21258252 Circulating Serum qRT-PCR The utility of miR-1254 and miR-574-5p serum-based biomarkers as minimally invasive screening and triage tools for subsequent diagnostic evaluation warrants additional validation. RLID00035364 MIMAT0005905 hsa-miR-1254 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005905 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00035365 MIMAT0005905 hsa-miR-1254 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005905 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035366 MIMAT0005905 hsa-miR-1254 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005905 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00035367 MIMAT0005905 hsa-miR-1254 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005905 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035368 MIMAT0005905 hsa-miR-1254 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005905 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035369 MIMAT0005905 hsa-miR-1254 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005905 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035370 MIMAT0005905 hsa-miR-1254 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005905 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035371 MIMAT0005905 hsa-miR-1254 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005905 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035372 MIMAT0005906 hsa-miR-1255a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005906 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035373 MIMAT0005906 hsa-miR-1255a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005906 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035374 MIMAT0005906 hsa-miR-1255a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005906 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035375 MIMAT0005907 hsa-miR-1256 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005907 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035376 MIMAT0005908 hsa-miR-1257 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005908 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035377 MIMAT0005911 hsa-miR-1260a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005911 hsa-miR-1260 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035378 MIMAT0005911 hsa-miR-1260a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005911 hsa-miR-1260 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00035379 MIMAT0005911 hsa-miR-1260a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005911 hsa-miR-1260 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035380 MIMAT0005911 hsa-miR-1260a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005911 hsa-miR-1260 miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR "Even under such stringent criteria, 11 miRNAs can be identified as miRNAs that are detectable in the nucleolus with very high levels of confidence (Figure 1D, Table S2). Since the detected nucleolar contents of many of these RNAs are very high, we termed these 11 miRNAs as nucleolar miRNAs. " RLID00035381 MIMAT0005914 hsa-miR-1262 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005914 miRNA Homo sapiens 25405200 Circulating Serum qRT-PCR "Individual qRT-PCR results (expression level) of serum miRNA expression in macrosomia and controls is shown in Table 3, including has-miR-122, has-miR-192, has-miR-194, has-miR-296-5p, has-miR-376a, has-miR-487b, has-miR-505, has-miR-1262 " RLID00035382 MIMAT0005914 hsa-miR-1262 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005914 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035383 MIMAT0005914 hsa-miR-1262 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005914 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035384 MIMAT0005915 hsa-miR-1263 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005915 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035385 MIMAT0005920 hsa-miR-1266-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005920 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035386 MIMAT0005920 hsa-miR-1266-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005920 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00035387 MIMAT0005922 hsa-miR-1268a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005922 hsa-miR-1268 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035388 MIMAT0005922 hsa-miR-1268a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005922 hsa-miR-1268 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00035389 MIMAT0005922 hsa-miR-1268a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005922 hsa-miR-1268 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00035390 MIMAT0005922 hsa-miR-1268a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005922 hsa-miR-1268 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035391 MIMAT0005922 hsa-miR-1268a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005922 hsa-miR-1268 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00035392 MIMAT0005922 hsa-miR-1268a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005922 hsa-miR-1268 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035393 MIMAT0005922 hsa-miR-1268a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005922 hsa-miR-1268 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035394 MIMAT0005922 hsa-miR-1268a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005922 hsa-miR-1268 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035395 MIMAT0005924 hsa-miR-1270 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005924 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035396 MIMAT0005924 hsa-miR-1270 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005924 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00035397 MIMAT0005924 hsa-miR-1270 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005924 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035398 MIMAT0005924 hsa-miR-1270 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005924 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00035399 MIMAT0005925 hsa-miR-1272 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005925 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035400 MIMAT0005925 hsa-miR-1272 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005925 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035401 MIMAT0005926 hsa-miR-1273a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005926 hsa-miR-1273 miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00035402 MIMAT0005928 hsa-miR-548h-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005928 hsa-miR-548h miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035403 MIMAT0005928 hsa-miR-548h-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005928 hsa-miR-548h miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035404 MIMAT0005929 hsa-miR-1275 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005929 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00035405 MIMAT0005929 hsa-miR-1275 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005929 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035406 MIMAT0005929 hsa-miR-1275 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005929 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035407 MIMAT0005929 hsa-miR-1275 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005929 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00035408 MIMAT0005929 hsa-miR-1275 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005929 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035409 MIMAT0005929 hsa-miR-1275 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005929 miRNA Homo sapiens 23940654 Nucleolus HeLa cell qRT-PCR "Even under such stringent criteria, 11 miRNAs can be identified as miRNAs that are detectable in the nucleolus with very high levels of confidence (Figure 1D, Table S2). Since the detected nucleolar contents of many of these RNAs are very high, we termed these 11 miRNAs as nucleolar miRNAs. " RLID00035410 MIMAT0005929 hsa-miR-1275 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005929 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035411 MIMAT0005929 hsa-miR-1275 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005929 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00035412 MIMAT0005929 hsa-miR-1275 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005929 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray|RT-PCR "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00035413 MIMAT0005930 hsa-miR-1276 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005930 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035414 MIMAT0005931 hsa-miR-302e http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005931 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035415 MIMAT0005933 hsa-miR-1277-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005933 hsa-miR-1277 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035416 MIMAT0005936 hsa-miR-1278 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005936 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035417 MIMAT0005936 hsa-miR-1278 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005936 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035418 MIMAT0005939 hsa-miR-1281 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005939 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035419 MIMAT0005939 hsa-miR-1281 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005939 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035420 MIMAT0005941 hsa-miR-1284 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005941 miRNA Homo sapiens 23056502 Exosome Epidermal melanocyte Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035421 MIMAT0005943 hsa-miR-1292-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005943 hsa-miR-1292 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00035422 MIMAT0005943 hsa-miR-1292-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005943 hsa-miR-1292 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035423 MIMAT0005943 hsa-miR-1292-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005943 hsa-miR-1292 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035424 MIMAT0005943 hsa-miR-1292-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005943 hsa-miR-1292 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035425 MIMAT0005943 hsa-miR-1292-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005943 hsa-miR-1292 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035426 MIMAT0005943 hsa-miR-1292-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005943 hsa-miR-1292 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035427 MIMAT0005945 hsa-miR-1255b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005945 hsa-miR-1255b miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035428 MIMAT0005945 hsa-miR-1255b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005945 hsa-miR-1255b miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00035429 MIMAT0005948 hsa-miR-664a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005948 "hsa-miR-664*, hsa-miR-664-5p " miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035430 MIMAT0005948 hsa-miR-664a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005948 "hsa-miR-664*, hsa-miR-664-5p " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035431 MIMAT0005948 hsa-miR-664a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005948 "hsa-miR-664*, hsa-miR-664-5p " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035432 MIMAT0005948 hsa-miR-664a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005948 "hsa-miR-664*, hsa-miR-664-5p " miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035433 MIMAT0005948 hsa-miR-664a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005948 "hsa-miR-664*, hsa-miR-664-5p " miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035434 MIMAT0005948 hsa-miR-664a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005948 "hsa-miR-664*, hsa-miR-664-5p " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035435 MIMAT0005948 hsa-miR-664a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005948 "hsa-miR-664*, hsa-miR-664-5p " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035436 MIMAT0005948 hsa-miR-664a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005948 "hsa-miR-664*, hsa-miR-664-5p " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00035437 MIMAT0005949 hsa-miR-664a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005949 "hsa-miR-664, hsa-miR-664-3p " miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035438 MIMAT0005949 hsa-miR-664a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005949 "hsa-miR-664, hsa-miR-664-3p " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035439 MIMAT0005949 hsa-miR-664a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005949 "hsa-miR-664, hsa-miR-664-3p " miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035440 MIMAT0005949 hsa-miR-664a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005949 "hsa-miR-664, hsa-miR-664-3p " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00035441 MIMAT0005949 hsa-miR-664a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005949 "hsa-miR-664, hsa-miR-664-3p " miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035442 MIMAT0005949 hsa-miR-664a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005949 "hsa-miR-664, hsa-miR-664-3p " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035443 MIMAT0005949 hsa-miR-664a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005949 "hsa-miR-664, hsa-miR-664-3p " miRNA Homo sapiens 25330373 Microvesicle Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00035444 MIMAT0005949 hsa-miR-664a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005949 "hsa-miR-664, hsa-miR-664-3p " miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00035445 MIMAT0005949 hsa-miR-664a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005949 "hsa-miR-664, hsa-miR-664-3p " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035446 MIMAT0005949 hsa-miR-664a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005949 "hsa-miR-664, hsa-miR-664-3p " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035447 MIMAT0005950 hsa-miR-1306-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005950 hsa-miR-1306 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035448 MIMAT0005950 hsa-miR-1306-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005950 hsa-miR-1306 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035449 MIMAT0005950 hsa-miR-1306-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005950 hsa-miR-1306 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035450 MIMAT0005950 hsa-miR-1306-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005950 hsa-miR-1306 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035451 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035452 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035453 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035454 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035455 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00035456 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035457 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035458 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035459 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035460 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035461 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035462 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035463 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035464 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035465 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00035466 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 24918059 Nucleus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00035467 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00035468 MIMAT0005951 hsa-miR-1307-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005951 hsa-miR-1307 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00035469 MIMAT0005953 hsa-miR-1322 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005953 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00035470 MIMAT0005955 hsa-miR-1197 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005955 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00035471 MIMAT0005955 hsa-miR-1197 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0005955 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035472 MIMAT0006018 ssc-miR-99b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006018 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035473 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035474 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035475 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00035476 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035477 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00035478 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 23077538 Microvesicle Plasma Next-generation sequencing "To characterize the stability of secreted miRNAs in plasma, we selected eight plasma miRNAs with relatively high copy numbers detected by Solexa sequencing (Table S1).Data are collected from Table S1: Plasma miRNA level detected by Solexa Sequencing. Total miRNA copy number = 3780436. Only miRNAs with copy number >= 1500 were shown. " RLID00035479 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035480 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S9. The expression level of all microRNAs that detected in the nuclear and cytoplasmic 18-30nt sRNA of 293T cell line. Table S5. The N/C values of all isomiRs. The isomiRs are shown only if it displayed a raw read count (non-normalized) more than 10 in at least one library. Data are collected from Table S5, S9. " RLID00035481 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035482 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035483 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00035484 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035485 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035486 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 24918059 Cytoplasm HeLa|MCF7 Microarray Data are collected from supplementary Table S2. MiRNA reads in the subcellular fractions. RLID00035487 MIMAT0006764 hsa-miR-320d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006764 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00035488 MIMAT0006765 hsa-miR-1825 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006765 miRNA Homo sapiens 23056502 Exosome Malignant melanoma cell Microarray "To distinguish miRNA signatures between melanoma cell-derived exosomes and normal melanocyte-derived exosomes, we compared the miRNome in A375 and HEMa-LP exosomes. We identified 130 miRNAs upregulated and 98 miRNAs downregulated in A375 versus HEMa-LP exosomes (Table S6). Data are collected from table S6. " RLID00035489 MIMAT0006767 hsa-miR-1827 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006767 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00035490 MIMAT0006778 hsa-miR-516a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006778 miRNA Homo sapiens 21505438 Exosome B cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00035491 MIMAT0006778 hsa-miR-516a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006778 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035492 MIMAT0006786 ssc-miR-140-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006786 ssc-miR-140* miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035493 MIMAT0006789 hsa-miR-1468-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006789 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035494 MIMAT0006789 hsa-miR-1468-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006789 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00035495 MIMAT0006790 hsa-miR-675-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0006790 "hsa-miR-675b, hsa-miR-675* " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00035496 MIMAT0007347 hsa-miR-1469 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007347 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00035497 MIMAT0007347 hsa-miR-1469 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007347 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00035498 MIMAT0007347 hsa-miR-1469 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007347 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035499 MIMAT0007402 hsa-miR-103b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007402 hsa-miR-103-as miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035500 MIMAT0007402 hsa-miR-103b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007402 hsa-miR-103-as miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035501 MIMAT0007753 ssc-miR-15a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007753 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035502 MIMAT0007754 ssc-miR-16 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007754 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035503 MIMAT0007755 ssc-miR-17-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007755 ssc-miR-17 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035504 MIMAT0007756 ssc-miR-30b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007756 ssc-miR-30b miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035505 MIMAT0007757 ssc-miR-34a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007757 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035506 MIMAT0007758 ssc-miR-130a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007758 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035507 MIMAT0007759 ssc-miR-185 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007759 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035508 MIMAT0007760 ssc-miR-199b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007760 ssc-miR-199b* miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035509 MIMAT0007761 ssc-miR-210 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007761 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035510 MIMAT0007762 ssc-miR-221-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007762 ssc-miR-221 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035511 MIMAT0007871 mmu-miR-1892 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007871 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00035512 MIMAT0007872 mmu-miR-1906 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007872 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00035513 MIMAT0007881 hsa-miR-1908-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007881 miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00035514 MIMAT0007881 hsa-miR-1908-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007881 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035515 MIMAT0007881 hsa-miR-1908-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007881 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00035516 MIMAT0007881 hsa-miR-1908-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007881 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00035517 MIMAT0007881 hsa-miR-1908-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007881 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035518 MIMAT0007881 hsa-miR-1908-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007881 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00035519 MIMAT0007881 hsa-miR-1908-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007881 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035520 MIMAT0007881 hsa-miR-1908-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007881 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035521 MIMAT0007881 hsa-miR-1908-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007881 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035522 MIMAT0007881 hsa-miR-1908-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007881 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035523 MIMAT0007881 hsa-miR-1908-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007881 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray|RT-PCR "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00035524 MIMAT0007881 hsa-miR-1908-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007881 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00035525 MIMAT0007882 hsa-miR-1909-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007882 hsa-miR-1909* miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00035526 MIMAT0007883 hsa-miR-1909-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007883 hsa-miR-1909 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00035527 MIMAT0007883 hsa-miR-1909-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007883 hsa-miR-1909 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035528 MIMAT0007884 hsa-miR-1910-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007884 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035529 MIMAT0007885 hsa-miR-1911-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007885 hsa-miR-1911 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035530 MIMAT0007885 hsa-miR-1911-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007885 hsa-miR-1911 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035531 MIMAT0007886 hsa-miR-1911-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007886 hsa-miR-1911* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035532 MIMAT0007887 hsa-miR-1912 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007887 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035533 MIMAT0007890 hsa-miR-1914-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007890 hsa-miR-1914* miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00035534 MIMAT0007892 hsa-miR-1915-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007892 hsa-miR-1915 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00035535 MIMAT0007892 hsa-miR-1915-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007892 hsa-miR-1915 miRNA Homo sapiens 23169280 Circulating Serum Microarray "Table 2 miRNAs detected in pooled patient and control samples, as detected by Agilent Human miRNA microarrays. All of these showed potential as biomarkers as the levels of miRNAs varied between the patient and control groups. The expression levels of six of these miRNAs (in bold) were verified using TaqMan qRT–PCR. Three miRNAs (miR-720, miR-1246 and miR-1308) chosen for further analysis in individual patient samples. TaqMan qRT–PCR assays for the remaining three miRNAs were not available or were unreliable. Data are collected from Table 2. " RLID00035536 MIMAT0007892 hsa-miR-1915-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007892 hsa-miR-1915 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00035537 MIMAT0007892 hsa-miR-1915-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0007892 hsa-miR-1915 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035538 MIMAT0009196 hsa-miR-103a-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009196 "hsa-miR-103-2*, hsa-miR-103a-2* " miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035539 MIMAT0009196 hsa-miR-103a-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009196 "hsa-miR-103-2*, hsa-miR-103a-2* " miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00035540 MIMAT0009196 hsa-miR-103a-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009196 "hsa-miR-103-2*, hsa-miR-103a-2* " miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035541 MIMAT0009196 hsa-miR-103a-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009196 "hsa-miR-103-2*, hsa-miR-103a-2* " miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00035542 MIMAT0009196 hsa-miR-103a-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009196 "hsa-miR-103-2*, hsa-miR-103a-2* " miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035543 MIMAT0009196 hsa-miR-103a-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009196 "hsa-miR-103-2*, hsa-miR-103a-2* " miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035544 MIMAT0009197 hsa-miR-205-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009197 hsa-miR-205* miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00035545 MIMAT0009199 hsa-miR-365a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009199 hsa-miR-365* miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035546 MIMAT0009199 hsa-miR-365a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009199 hsa-miR-365* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035547 MIMAT0009199 hsa-miR-365a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009199 hsa-miR-365* miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00035548 MIMAT0009199 hsa-miR-365a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009199 hsa-miR-365* miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035549 MIMAT0009199 hsa-miR-365a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009199 hsa-miR-365* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035550 MIMAT0009199 hsa-miR-365a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009199 hsa-miR-365* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035551 MIMAT0009201 hsa-miR-196b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009201 hsa-miR-196b* miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035552 MIMAT0009206 hsa-miR-2113 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009206 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035553 MIMAT0009218 bta-miR-106b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009218 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00035554 MIMAT0009232 bta-miR-141 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009232 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00035555 MIMAT0009233 bta-miR-143 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009233 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00035556 MIMAT0009242 bta-miR-16a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009242 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00035557 MIMAT0009270 bta-miR-223 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009270 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00035558 MIMAT0009315 bta-miR-429 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009315 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00035559 MIMAT0009416 mmu-miR-1949 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009416 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00035560 MIMAT0009447 hsa-miR-1972 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009447 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00035561 MIMAT0009447 hsa-miR-1972 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009447 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray|RT-PCR "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00035562 MIMAT0009448 hsa-miR-1973 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009448 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00035563 MIMAT0009448 hsa-miR-1973 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009448 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00035564 MIMAT0009448 hsa-miR-1973 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009448 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00035565 MIMAT0009448 hsa-miR-1973 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009448 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray|RT-PCR "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00035566 MIMAT0009451 hsa-miR-1976 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009451 miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00035567 MIMAT0009451 hsa-miR-1976 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0009451 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00035568 MIMAT0010133 hsa-miR-2110 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010133 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035569 MIMAT0010133 hsa-miR-2110 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010133 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035570 MIMAT0010133 hsa-miR-2110 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010133 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00035571 MIMAT0010133 hsa-miR-2110 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010133 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035572 MIMAT0010133 hsa-miR-2110 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010133 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035573 MIMAT0010133 hsa-miR-2110 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010133 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00035574 MIMAT0010133 hsa-miR-2110 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010133 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035575 MIMAT0010133 hsa-miR-2110 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010133 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035576 MIMAT0010133 hsa-miR-2110 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010133 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035577 MIMAT0010133 hsa-miR-2110 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010133 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00035578 MIMAT0010133 hsa-miR-2110 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010133 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035579 MIMAT0010133 hsa-miR-2110 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010133 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035580 MIMAT0010133 hsa-miR-2110 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010133 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00035581 MIMAT0010185 ssc-miR-101 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010185 ssc-miR-101a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035582 MIMAT0010186 ssc-miR-133a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010186 ssc-miR-133a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035583 MIMAT0010187 ssc-miR-1 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010187 ssc-miR-1a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035584 MIMAT0010190 ssc-miR-146b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010190 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035585 MIMAT0010191 ssc-miR-181a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010191 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035586 MIMAT0010193 ssc-miR-30a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010193 ssc-miR-30a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035587 MIMAT0010195 hsa-let-7a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010195 hsa-let-7a-2* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035588 MIMAT0010195 hsa-let-7a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010195 hsa-let-7a-2* miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035589 MIMAT0010214 hsa-miR-151b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010214 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00035590 MIMAT0010214 hsa-miR-151b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010214 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035591 MIMAT0010214 hsa-miR-151b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010214 miRNA Homo sapiens 24577456 Circulating Serum Next-generation sequencing The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. Table 2 has displayed the data. RLID00035592 MIMAT0010251 hsa-miR-449c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010251 hsa-miR-449c miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00035593 MIMAT0010313 hsa-miR-762 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010313 miRNA Homo sapiens 23169280 Circulating Serum Microarray "Table 2 miRNAs detected in pooled patient and control samples, as detected by Agilent Human miRNA microarrays. All of these showed potential as biomarkers as the levels of miRNAs varied between the patient and control groups. The expression levels of six of these miRNAs (in bold) were verified using TaqMan qRT–PCR. Three miRNAs (miR-720, miR-1246 and miR-1308) chosen for further analysis in individual patient samples. TaqMan qRT–PCR assays for the remaining three miRNAs were not available or were unreliable. Data are collected from Table 2. " RLID00035594 MIMAT0010313 hsa-miR-762 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010313 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035595 MIMAT0010313 hsa-miR-762 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0010313 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00035596 MIMAT0011159 hsa-miR-2115-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0011159 hsa-miR-2115* miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00035597 MIMAT0011160 hsa-miR-2116-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0011160 hsa-miR-2116 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035598 MIMAT0011212 mmu-miR-2136 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0011212 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00035599 MIMAT0011777 hsa-miR-2277-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0011777 hsa-miR-2277 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00035600 MIMAT0011778 hsa-miR-2278 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0011778 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00035601 MIMAT0012038 bta-miR-339b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0012038 miRNA Bos taurus 24614226 Extracellular vesicle Luminal fluid Next-generation sequencing "This analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). his analysis found 81 conserved mature miRNAs in the ULF extracellular vesicle small RNA sequences, with 53 in common between cyclic and pregnant samples and 1 unique annotated miRNA (bta-miR-423) in the day 14 pregnant samples (Fig. 5). Data are collected from Figure 5. " RLID00035602 MIMAT0012734 hsa-miR-711 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0012734 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00035603 MIMAT0012737 mdo-miR-148-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0012737 miRNA Monodelphis domestica 25417092 Exosome Milk Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00035604 MIMAT0012751 mdo-miR-215 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0012751 miRNA Monodelphis domestica 25417092 Exosome Serum Next-generation sequencing The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2).The ten most highly abundant miRNAs in milk at five lactation time points and blood serum samples at day 118 and 175 of lactation are summarized in (see Additional file 2). Data are collceted from Table S2. RLID00035605 MIMAT0012771 mmu-miR-432 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0012771 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00035606 MIMAT0012830 rno-miR-504 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0012830 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035607 MIMAT0012852 rno-miR-667-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0012852 rno-miR-667 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00035608 MIMAT0012951 eca-miR-101 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0012951 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035609 MIMAT0012952 eca-miR-135b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0012952 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035610 MIMAT0012959 eca-miR-197 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0012959 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035611 MIMAT0012966 eca-miR-92b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0012966 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035612 MIMAT0012986 eca-miR-23a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0012986 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035613 MIMAT0012987 eca-miR-24 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0012987 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035614 MIMAT0013005 eca-miR-30b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013005 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035615 MIMAT0013021 eca-miR-132 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013021 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035616 MIMAT0013027 eca-miR-195 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013027 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035617 MIMAT0013029 eca-miR-21 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013029 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035618 MIMAT0013031 eca-miR-22 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013031 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035619 MIMAT0013049 eca-miR-192 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013049 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035620 MIMAT0013057 eca-miR-25 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013057 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035621 MIMAT0013060 eca-miR-93 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013060 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035622 MIMAT0013068 eca-miR-378 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013068 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035623 MIMAT0013078 eca-miR-135a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013078 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035624 MIMAT0013079 eca-miR-191a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013079 eca-miR-191 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035625 MIMAT0013084 eca-miR-17 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013084 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035626 MIMAT0013087 eca-miR-19b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013087 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035627 MIMAT0013088 eca-miR-20a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013088 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035628 MIMAT0013089 eca-miR-92a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013089 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035629 MIMAT0013109 eca-miR-499-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013109 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035630 MIMAT0013113 eca-miR-23b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013113 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035631 MIMAT0013131 eca-miR-323-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013131 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035632 MIMAT0013158 eca-miR-433 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013158 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035633 MIMAT0013160 eca-miR-485-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013160 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035634 MIMAT0013178 eca-miR-181a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013178 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035635 MIMAT0013186 eca-miR-486-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013186 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035636 MIMAT0013190 eca-miR-215 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013190 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035637 MIMAT0013202 eca-miR-20b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013202 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035638 MIMAT0013205 eca-miR-223 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013205 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035639 MIMAT0013210 eca-miR-362-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013210 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035640 MIMAT0013216 eca-miR-421 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013216 miRNA Equus caballus 22116803 Exosome Follicular cell qRT-PCR TABLE 2: MicroRNAs enriched in microvesicle and exosome preparations obtained from follicular fluid. Data are collected from Table 2. RLID00035641 MIMAT0013771 hsa-miR-449c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013771 hsa-miR-449c* miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00035642 MIMAT0013802 hsa-miR-2861 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013802 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00035643 MIMAT0013864 ssc-miR-206 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013864 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035644 MIMAT0013865 ssc-let-7a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013865 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035645 MIMAT0013866 ssc-let-7e http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013866 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035646 MIMAT0013867 ssc-let-7g http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013867 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035647 MIMAT0013868 ssc-miR-378 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013868 miRNA Sus scrofa 25158130 Extracellular vesicle Mesenchymal stem cell Next-generation sequencing "RNA-seq generated reads for at least 386 annotated miRNAs, but only miR148a, miR532-5p, miR378, and let-7f were enriched in EVs compared to MSCs. " RLID00035648 MIMAT0013868 ssc-miR-378 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013868 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035649 MIMAT0013870 ssc-miR-29a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013870 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035650 MIMAT0013871 ssc-miR-30d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013871 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035651 MIMAT0013872 ssc-miR-30e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013872 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035652 MIMAT0013873 ssc-miR-30e-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013873 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035653 MIMAT0013874 ssc-miR-199a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013874 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035654 MIMAT0013875 ssc-miR-199a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013875 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035655 MIMAT0013876 ssc-miR-191 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013876 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035656 MIMAT0013877 ssc-miR-499-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013877 ssc-miR-499 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035657 MIMAT0013878 ssc-miR-320 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013878 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035658 MIMAT0013879 ssc-miR-143-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013879 ssc-miR-143 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035659 MIMAT0013880 ssc-miR-423-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013880 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035660 MIMAT0013881 ssc-miR-423-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013881 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035661 MIMAT0013882 ssc-miR-151-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013882 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035662 MIMAT0013883 ssc-miR-151-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013883 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035663 MIMAT0013884 ssc-miR-10a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013884 ssc-miR-10a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035664 MIMAT0013885 ssc-miR-10b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013885 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035665 MIMAT0013886 ssc-miR-486 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013886 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035666 MIMAT0013887 ssc-miR-152 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013887 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035667 MIMAT0013888 ssc-miR-181d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013888 ssc-miR-181d miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035668 MIMAT0013889 ssc-miR-27b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013889 ssc-miR-27b* miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035669 MIMAT0013890 ssc-miR-27b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013890 ssc-miR-27b miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035670 MIMAT0013891 ssc-miR-340 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013891 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035671 MIMAT0013893 ssc-miR-23b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013893 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035672 MIMAT0013894 ssc-miR-193a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013894 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035673 MIMAT0013895 ssc-miR-193a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013895 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035674 MIMAT0013896 ssc-miR-99a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013896 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035675 MIMAT0013897 ssc-miR-125a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013897 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035676 MIMAT0013899 ssc-miR-345-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013899 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035677 MIMAT0013900 ssc-miR-345-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013900 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035678 MIMAT0013901 ssc-miR-148b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013901 ssc-miR-148b miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035679 MIMAT0013902 ssc-miR-885-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013902 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035680 MIMAT0013903 ssc-miR-885-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013903 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035681 MIMAT0013904 ssc-miR-365-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013904 ssc-miR-365 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035682 MIMAT0013905 ssc-miR-98 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013905 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035683 MIMAT0013906 ssc-miR-664-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013906 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035684 MIMAT0013907 ssc-miR-664-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013907 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035685 MIMAT0013908 ssc-miR-92a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013908 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035686 MIMAT0013909 ssc-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013909 ssc-miR-92b miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035687 MIMAT0013910 ssc-miR-192 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013910 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035688 MIMAT0013911 ssc-miR-100 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013911 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035689 MIMAT0013913 ssc-miR-374a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013913 ssc-miR-374a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035690 MIMAT0013914 ssc-miR-374a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013914 ssc-miR-374a* miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035691 MIMAT0013915 ssc-miR-374b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013915 ssc-miR-374b miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035692 MIMAT0013916 ssc-miR-34c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013916 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035693 MIMAT0013917 ssc-miR-425-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013917 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035694 MIMAT0013918 ssc-miR-425-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013918 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035695 MIMAT0013919 ssc-miR-142-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013919 ssc-miR-142 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035696 MIMAT0013922 ssc-miR-130b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013922 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035697 MIMAT0013926 ssc-miR-497 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013926 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035698 MIMAT0013929 ssc-miR-331-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013929 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035699 MIMAT0013930 ssc-miR-331-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013930 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035700 MIMAT0013931 ssc-miR-504 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013931 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035701 MIMAT0013932 ssc-miR-127 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013932 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035702 MIMAT0013933 ssc-miR-361-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013933 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035703 MIMAT0013934 ssc-miR-361-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013934 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035704 MIMAT0013936 ssc-miR-1307 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013936 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035705 MIMAT0013937 ssc-miR-1306-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013937 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035706 MIMAT0013938 ssc-miR-1306-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013938 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035707 MIMAT0013939 ssc-miR-339-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013939 ssc-miR-339 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035708 MIMAT0013940 ssc-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013940 miRNA Sus scrofa 25158130 Extracellular vesicle Mesenchymal stem cell Next-generation sequencing "RNA-seq generated reads for at least 386 annotated miRNAs, but only miR148a, miR532-5p, miR378, and let-7f were enriched in EVs compared to MSCs. " RLID00035709 MIMAT0013940 ssc-miR-532-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013940 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035710 MIMAT0013941 ssc-miR-532-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013941 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035711 MIMAT0013942 ssc-miR-222 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013942 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035712 MIMAT0013943 ssc-miR-676-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013943 ssc-miR-676 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035713 MIMAT0013944 ssc-miR-342 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013944 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035714 MIMAT0013947 ssc-miR-935 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013947 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035715 MIMAT0013949 ssc-miR-328 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013949 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035716 MIMAT0013950 ssc-miR-19b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013950 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035717 MIMAT0013951 ssc-miR-574 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013951 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035718 MIMAT0013952 ssc-miR-1839-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013952 ssc-miR-1839 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035719 MIMAT0013954 ssc-miR-1285 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013954 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035720 MIMAT0013956 ssc-miR-500 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013956 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035721 MIMAT0013957 ssc-miR-324 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013957 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035722 MIMAT0013958 ssc-miR-769-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013958 ssc-miR-769 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035723 MIMAT0013959 ssc-miR-129a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013959 ssc-miR-129a miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035724 MIMAT0013960 ssc-miR-455-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013960 ssc-miR-455 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035725 MIMAT0013961 ssc-miR-505 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0013961 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00035726 MIMAT0014207 aae-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014207 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035727 MIMAT0014207 aae-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014207 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035728 MIMAT0014207 aae-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014207 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035729 MIMAT0014207 aae-miR-184 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014207 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035730 MIMAT0014208 aae-miR-275-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014208 aae-miR-275* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035731 MIMAT0014208 aae-miR-275-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014208 aae-miR-275* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035732 MIMAT0014208 aae-miR-275-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014208 aae-miR-275* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035733 MIMAT0014208 aae-miR-275-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014208 aae-miR-275* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035734 MIMAT0014209 aae-miR-275-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014209 aae-miR-275 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035735 MIMAT0014209 aae-miR-275-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014209 aae-miR-275 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035736 MIMAT0014209 aae-miR-275-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014209 aae-miR-275 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035737 MIMAT0014209 aae-miR-275-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014209 aae-miR-275 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035738 MIMAT0014211 aae-miR-277-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014211 aae-miR-277 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035739 MIMAT0014211 aae-miR-277-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014211 aae-miR-277 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035740 MIMAT0014211 aae-miR-277-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014211 aae-miR-277 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035741 MIMAT0014211 aae-miR-277-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014211 aae-miR-277 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035742 MIMAT0014212 aae-miR-9c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014212 aae-miR-9 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035743 MIMAT0014212 aae-miR-9c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014212 aae-miR-9 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035744 MIMAT0014212 aae-miR-9c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014212 aae-miR-9 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035745 MIMAT0014212 aae-miR-9c-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014212 aae-miR-9 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035746 MIMAT0014213 aae-miR-9c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014213 aae-miR-9* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035747 MIMAT0014213 aae-miR-9c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014213 aae-miR-9* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035748 MIMAT0014213 aae-miR-9c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014213 aae-miR-9* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035749 MIMAT0014213 aae-miR-9c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014213 aae-miR-9* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035750 MIMAT0014214 aae-miR-8-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014214 aae-miR-8* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035751 MIMAT0014214 aae-miR-8-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014214 aae-miR-8* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035752 MIMAT0014214 aae-miR-8-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014214 aae-miR-8* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035753 MIMAT0014214 aae-miR-8-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014214 aae-miR-8* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035754 MIMAT0014215 aae-miR-8-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014215 aae-miR-8 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035755 MIMAT0014215 aae-miR-8-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014215 aae-miR-8 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035756 MIMAT0014215 aae-miR-8-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014215 aae-miR-8 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035757 MIMAT0014215 aae-miR-8-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014215 aae-miR-8 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035758 MIMAT0014216 aae-miR-252-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014216 aae-miR-252 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035759 MIMAT0014216 aae-miR-252-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014216 aae-miR-252 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035760 MIMAT0014216 aae-miR-252-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014216 aae-miR-252 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035761 MIMAT0014218 aae-bantam-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014218 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035762 MIMAT0014218 aae-bantam-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014218 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035763 MIMAT0014218 aae-bantam-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014218 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035764 MIMAT0014218 aae-bantam-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014218 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035765 MIMAT0014219 aae-bantam-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014219 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035766 MIMAT0014219 aae-bantam-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014219 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035767 MIMAT0014219 aae-bantam-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014219 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035768 MIMAT0014219 aae-bantam-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014219 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035769 MIMAT0014220 aae-miR-71-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014220 aae-miR-71 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035770 MIMAT0014220 aae-miR-71-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014220 aae-miR-71 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035771 MIMAT0014220 aae-miR-71-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014220 aae-miR-71 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035772 MIMAT0014220 aae-miR-71-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014220 aae-miR-71 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035773 MIMAT0014221 aae-miR-71-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014221 aae-miR-71* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035774 MIMAT0014221 aae-miR-71-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014221 aae-miR-71* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035775 MIMAT0014221 aae-miR-71-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014221 aae-miR-71* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035776 MIMAT0014221 aae-miR-71-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014221 aae-miR-71* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035777 MIMAT0014223 aae-miR-276-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014223 aae-miR-276 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035778 MIMAT0014223 aae-miR-276-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014223 aae-miR-276 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035779 MIMAT0014223 aae-miR-276-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014223 aae-miR-276 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035780 MIMAT0014223 aae-miR-276-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014223 aae-miR-276 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035781 MIMAT0014224 aae-miR-317 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014224 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035782 MIMAT0014224 aae-miR-317 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014224 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035783 MIMAT0014224 aae-miR-317 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014224 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035784 MIMAT0014224 aae-miR-317 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014224 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035785 MIMAT0014226 aae-miR-2a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014226 aae-miR-2a miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035786 MIMAT0014226 aae-miR-2a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014226 aae-miR-2a miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035787 MIMAT0014226 aae-miR-2a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014226 aae-miR-2a miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035788 MIMAT0014226 aae-miR-2a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014226 aae-miR-2a miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035789 MIMAT0014227 aae-miR-998 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014227 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035790 MIMAT0014227 aae-miR-998 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014227 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035791 MIMAT0014227 aae-miR-998 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014227 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035792 MIMAT0014227 aae-miR-998 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014227 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035793 MIMAT0014228 aae-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014228 aae-miR-92a miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035794 MIMAT0014228 aae-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014228 aae-miR-92a miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035795 MIMAT0014228 aae-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014228 aae-miR-92a miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035796 MIMAT0014228 aae-miR-92a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014228 aae-miR-92a miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035797 MIMAT0014229 aae-miR-306-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014229 aae-miR-306 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035798 MIMAT0014229 aae-miR-306-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014229 aae-miR-306 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035799 MIMAT0014229 aae-miR-306-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014229 aae-miR-306 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035800 MIMAT0014229 aae-miR-306-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014229 aae-miR-306 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035801 MIMAT0014230 aae-miR-306-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014230 aae-miR-306* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035802 MIMAT0014230 aae-miR-306-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014230 aae-miR-306* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035803 MIMAT0014230 aae-miR-306-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014230 aae-miR-306* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035804 MIMAT0014230 aae-miR-306-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014230 aae-miR-306* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035805 MIMAT0014231 aae-miR-281-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014231 aae-miR-281 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035806 MIMAT0014231 aae-miR-281-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014231 aae-miR-281 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035807 MIMAT0014231 aae-miR-281-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014231 aae-miR-281 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035808 MIMAT0014231 aae-miR-281-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014231 aae-miR-281 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035809 MIMAT0014232 aae-miR-281-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014232 aae-miR-281* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035810 MIMAT0014232 aae-miR-281-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014232 aae-miR-281* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035811 MIMAT0014232 aae-miR-281-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014232 aae-miR-281* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035812 MIMAT0014232 aae-miR-281-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014232 aae-miR-281* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035813 MIMAT0014233 aae-miR-1889-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014233 aae-miR-1889* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035814 MIMAT0014233 aae-miR-1889-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014233 aae-miR-1889* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035815 MIMAT0014233 aae-miR-1889-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014233 aae-miR-1889* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035816 MIMAT0014233 aae-miR-1889-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014233 aae-miR-1889* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035817 MIMAT0014234 aae-miR-1889-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014234 aae-miR-1889 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035818 MIMAT0014234 aae-miR-1889-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014234 aae-miR-1889 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035819 MIMAT0014234 aae-miR-1889-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014234 aae-miR-1889 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035820 MIMAT0014237 aae-miR-278-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014237 aae-miR-278 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035821 MIMAT0014237 aae-miR-278-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014237 aae-miR-278 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035822 MIMAT0014237 aae-miR-278-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014237 aae-miR-278 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035823 MIMAT0014237 aae-miR-278-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014237 aae-miR-278 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035824 MIMAT0014238 aae-miR-278-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014238 aae-miR-278* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035825 MIMAT0014238 aae-miR-278-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014238 aae-miR-278* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035826 MIMAT0014238 aae-miR-278-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014238 aae-miR-278* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035827 MIMAT0014238 aae-miR-278-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014238 aae-miR-278* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035828 MIMAT0014239 aae-miR-989 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014239 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035829 MIMAT0014239 aae-miR-989 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014239 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035830 MIMAT0014239 aae-miR-989 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014239 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035831 MIMAT0014239 aae-miR-989 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014239 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035832 MIMAT0014240 aae-miR-14 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014240 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035833 MIMAT0014240 aae-miR-14 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014240 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035834 MIMAT0014240 aae-miR-14 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014240 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035835 MIMAT0014240 aae-miR-14 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014240 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035836 MIMAT0014241 aae-miR-11-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014241 aae-miR-11* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035837 MIMAT0014241 aae-miR-11-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014241 aae-miR-11* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035838 MIMAT0014241 aae-miR-11-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014241 aae-miR-11* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035839 MIMAT0014242 aae-miR-11-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014242 aae-miR-11 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035840 MIMAT0014242 aae-miR-11-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014242 aae-miR-11 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035841 MIMAT0014242 aae-miR-11-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014242 aae-miR-11 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035842 MIMAT0014242 aae-miR-11-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014242 aae-miR-11 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035843 MIMAT0014243 aae-miR-190 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014243 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035844 MIMAT0014243 aae-miR-190 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014243 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035845 MIMAT0014243 aae-miR-190 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014243 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035846 MIMAT0014243 aae-miR-190 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014243 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035847 MIMAT0014244 aae-miR-1 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014244 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035848 MIMAT0014244 aae-miR-1 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014244 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035849 MIMAT0014245 aae-miR-34-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014245 aae-miR-34 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035850 MIMAT0014245 aae-miR-34-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014245 aae-miR-34 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035851 MIMAT0014245 aae-miR-34-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014245 aae-miR-34 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035852 MIMAT0014245 aae-miR-34-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014245 aae-miR-34 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035853 MIMAT0014246 aae-miR-34-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014246 aae-miR-34* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035854 MIMAT0014246 aae-miR-34-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014246 aae-miR-34* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035855 MIMAT0014246 aae-miR-34-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014246 aae-miR-34* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035856 MIMAT0014247 aae-miR-1890 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014247 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035857 MIMAT0014247 aae-miR-1890 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014247 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035858 MIMAT0014247 aae-miR-1890 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014247 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035859 MIMAT0014249 aae-miR-305-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014249 aae-miR-305 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035860 MIMAT0014249 aae-miR-305-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014249 aae-miR-305 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035861 MIMAT0014249 aae-miR-305-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014249 aae-miR-305 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035862 MIMAT0014249 aae-miR-305-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014249 aae-miR-305 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035863 MIMAT0014250 aae-miR-305-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014250 aae-miR-305* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035864 MIMAT0014250 aae-miR-305-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014250 aae-miR-305* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035865 MIMAT0014250 aae-miR-305-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014250 aae-miR-305* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035866 MIMAT0014250 aae-miR-305-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014250 aae-miR-305* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035867 MIMAT0014251 aae-miR-996 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014251 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035868 MIMAT0014251 aae-miR-996 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014251 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035869 MIMAT0014251 aae-miR-996 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014251 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035870 MIMAT0014251 aae-miR-996 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014251 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035871 MIMAT0014252 aae-miR-87 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014252 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035872 MIMAT0014252 aae-miR-87 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014252 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035873 MIMAT0014252 aae-miR-87 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014252 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035874 MIMAT0014252 aae-miR-87 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014252 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035875 MIMAT0014253 aae-miR-12-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014253 aae-miR-12 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035876 MIMAT0014253 aae-miR-12-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014253 aae-miR-12 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035877 MIMAT0014253 aae-miR-12-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014253 aae-miR-12 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035878 MIMAT0014253 aae-miR-12-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014253 aae-miR-12 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035879 MIMAT0014254 aae-miR-12-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014254 aae-miR-12* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035880 MIMAT0014254 aae-miR-12-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014254 aae-miR-12* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035881 MIMAT0014255 aae-miR-13-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014255 aae-miR-13* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035882 MIMAT0014255 aae-miR-13-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014255 aae-miR-13* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035883 MIMAT0014255 aae-miR-13-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014255 aae-miR-13* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035884 MIMAT0014255 aae-miR-13-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014255 aae-miR-13* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035885 MIMAT0014256 aae-miR-13-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014256 aae-miR-13 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035886 MIMAT0014256 aae-miR-13-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014256 aae-miR-13 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035887 MIMAT0014256 aae-miR-13-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014256 aae-miR-13 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035888 MIMAT0014256 aae-miR-13-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014256 aae-miR-13 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035889 MIMAT0014258 aae-miR-125-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014258 aae-miR-125 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035890 MIMAT0014258 aae-miR-125-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014258 aae-miR-125 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035891 MIMAT0014258 aae-miR-125-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014258 aae-miR-125 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035892 MIMAT0014260 aae-miR-308-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014260 aae-miR-308 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035893 MIMAT0014260 aae-miR-308-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014260 aae-miR-308 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035894 MIMAT0014264 aae-miR-1175-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014264 aae-miR-1175 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035895 MIMAT0014264 aae-miR-1175-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014264 aae-miR-1175 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035896 MIMAT0014265 aae-miR-1174 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014265 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035897 MIMAT0014265 aae-miR-1174 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014265 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035898 MIMAT0014268 aae-miR-965 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014268 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035899 MIMAT0014269 aae-miR-932-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014269 aae-miR-932* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035900 MIMAT0014270 aae-miR-932-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014270 aae-miR-932 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035901 MIMAT0014273 aae-miR-285 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014273 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035902 MIMAT0014273 aae-miR-285 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014273 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035903 MIMAT0014274 aae-miR-137 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014274 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035904 MIMAT0014274 aae-miR-137 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014274 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035905 MIMAT0014277 aae-miR-10 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014277 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035906 MIMAT0014277 aae-miR-10 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014277 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035907 MIMAT0014277 aae-miR-10 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014277 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035908 MIMAT0014279 aae-miR-283 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014279 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035909 MIMAT0014279 aae-miR-283 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014279 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035910 MIMAT0014279 aae-miR-283 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014279 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035911 MIMAT0014279 aae-miR-283 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014279 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035912 MIMAT0014280 aae-miR-988-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014280 aae-miR-988* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035913 MIMAT0014281 aae-miR-988-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014281 aae-miR-988 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035914 MIMAT0014281 aae-miR-988-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014281 aae-miR-988 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035915 MIMAT0014281 aae-miR-988-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014281 aae-miR-988 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035916 MIMAT0014281 aae-miR-988-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014281 aae-miR-988 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035917 MIMAT0014282 aae-miR-124 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014282 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035918 MIMAT0014282 aae-miR-124 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014282 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035919 MIMAT0014283 aae-miR-2940-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014283 aae-miR-2940 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035920 MIMAT0014283 aae-miR-2940-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014283 aae-miR-2940 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035921 MIMAT0014283 aae-miR-2940-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014283 aae-miR-2940 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035922 MIMAT0014283 aae-miR-2940-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014283 aae-miR-2940 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035923 MIMAT0014284 aae-miR-2940-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014284 aae-miR-2940* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035924 MIMAT0014284 aae-miR-2940-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014284 aae-miR-2940* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035925 MIMAT0014284 aae-miR-2940-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014284 aae-miR-2940* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035926 MIMAT0014284 aae-miR-2940-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014284 aae-miR-2940* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035927 MIMAT0014285 aae-miR-2765 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014285 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035928 MIMAT0014285 aae-miR-2765 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014285 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035929 MIMAT0014285 aae-miR-2765 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014285 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035930 MIMAT0014285 aae-miR-2765 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014285 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035931 MIMAT0014286 aae-miR-2941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014286 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035932 MIMAT0014286 aae-miR-2941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014286 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035933 MIMAT0014286 aae-miR-2941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014286 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035934 MIMAT0014286 aae-miR-2941 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014286 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035935 MIMAT0014287 aae-miR-33 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014287 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035936 MIMAT0014288 aae-miR-279 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014288 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035937 MIMAT0014288 aae-miR-279 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014288 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035938 MIMAT0014288 aae-miR-279 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014288 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035939 MIMAT0014288 aae-miR-279 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014288 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035940 MIMAT0014289 aae-miR-263a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014289 aae-miR-263a miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035941 MIMAT0014289 aae-miR-263a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014289 aae-miR-263a miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035942 MIMAT0014289 aae-miR-263a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014289 aae-miR-263a miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035943 MIMAT0014289 aae-miR-263a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014289 aae-miR-263a miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035944 MIMAT0014290 aae-miR-7 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014290 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035945 MIMAT0014290 aae-miR-7 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014290 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035946 MIMAT0014290 aae-miR-7 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014290 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035947 MIMAT0014290 aae-miR-7 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014290 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035948 MIMAT0014291 aae-miR-100 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014291 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035949 MIMAT0014291 aae-miR-100 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014291 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035950 MIMAT0014291 aae-miR-100 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014291 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035951 MIMAT0014291 aae-miR-100 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014291 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035952 MIMAT0014292 aae-miR-970 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014292 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035953 MIMAT0014292 aae-miR-970 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014292 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035954 MIMAT0014292 aae-miR-970 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014292 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035955 MIMAT0014292 aae-miR-970 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014292 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035956 MIMAT0014293 aae-miR-210 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014293 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035957 MIMAT0014295 aae-miR-79-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014295 aae-miR-79* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035958 MIMAT0014297 aae-miR-1000 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014297 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035959 MIMAT0014297 aae-miR-1000 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014297 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035960 MIMAT0014299 aae-let-7 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014299 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035961 MIMAT0014299 aae-let-7 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014299 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035962 MIMAT0014299 aae-let-7 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014299 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035963 MIMAT0014299 aae-let-7 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014299 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035964 MIMAT0014306 aae-miR-2b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014306 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035965 MIMAT0014306 aae-miR-2b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014306 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035966 MIMAT0014306 aae-miR-2b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014306 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035967 MIMAT0014306 aae-miR-2b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014306 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035968 MIMAT0014307 aae-miR-219 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014307 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035969 MIMAT0014311 aae-miR-282-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014311 aae-miR-282 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035970 MIMAT0014311 aae-miR-282-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014311 aae-miR-282 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035971 MIMAT0014311 aae-miR-282-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014311 aae-miR-282 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035972 MIMAT0014313 aae-miR-286b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014313 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035973 MIMAT0014316 aae-miR-2945-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014316 aae-miR-2945 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035974 MIMAT0014316 aae-miR-2945-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014316 aae-miR-2945 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035975 MIMAT0014316 aae-miR-2945-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014316 aae-miR-2945 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035976 MIMAT0014316 aae-miR-2945-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014316 aae-miR-2945 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035977 MIMAT0014322 aae-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014322 aae-miR-92b miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035978 MIMAT0014322 aae-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014322 aae-miR-92b miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035979 MIMAT0014322 aae-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014322 aae-miR-92b miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035980 MIMAT0014322 aae-miR-92b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014322 aae-miR-92b miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035981 MIMAT0014323 aae-miR-9a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014323 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035982 MIMAT0014323 aae-miR-9a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014323 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035983 MIMAT0014324 aae-miR-9b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014324 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035984 MIMAT0014324 aae-miR-9b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014324 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035985 MIMAT0014324 aae-miR-9b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014324 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035986 MIMAT0014324 aae-miR-9b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014324 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035987 MIMAT0014325 aae-miR-2946 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014325 miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035988 MIMAT0014325 aae-miR-2946 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014325 miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035989 MIMAT0014325 aae-miR-2946 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014325 miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035990 MIMAT0014325 aae-miR-2946 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014325 miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00035991 MIMAT0014351 hsv2-miR-H7-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014351 miRNA Human herpesvirus 2 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00035992 MIMAT0014353 hsv2-miR-H10 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014353 miRNA Human herpesvirus 2 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00035993 MIMAT0014708 hsv2-miR-H25 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014708 miRNA Human herpesvirus 2 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00035994 MIMAT0014901 mmu-miR-3090-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014901 mmu-miR-3090* miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00035995 MIMAT0014926 mmu-miR-344b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014926 mmu-miR-344b miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00035996 MIMAT0014933 mmu-miR-3102-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014933 mmu-miR-3102* miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00035997 MIMAT0014982 hsa-miR-3120-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014982 hsa-miR-3120 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00035998 MIMAT0014982 hsa-miR-3120-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014982 hsa-miR-3120 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00035999 MIMAT0014988 hsa-miR-3125 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014988 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036000 MIMAT0014989 hsa-miR-3126-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014989 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036001 MIMAT0014990 hsa-miR-3127-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014990 hsa-miR-3127 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036002 MIMAT0014995 hsa-miR-3130-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014995 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036003 MIMAT0014999 hsa-miR-378b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014999 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036004 MIMAT0014999 hsa-miR-378b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0014999 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00036005 MIMAT0015005 hsa-miR-3137 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015005 miRNA Homo sapiens 24352417 Circulating Blood platelet Next-generation sequencing "Platelets in both groups demonstrated miRNA expression profiles comparable to previously published data. The statistical analysis unveiled a signature of only three miRNAs (miR-377-5p, miR-628-3p, miR-3137) with high reselection probabilities in resampling techniques. " RLID00036006 MIMAT0015006 hsa-miR-3138 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015006 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036007 MIMAT0015009 hsa-miR-548t-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015009 hsa-miR-548t miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00036008 MIMAT0015010 hsa-miR-3141 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015010 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036009 MIMAT0015012 hsa-miR-3143 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015012 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036010 MIMAT0015027 hsa-miR-3074-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015027 hsa-miR-3074 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036011 MIMAT0015027 hsa-miR-3074-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015027 hsa-miR-3074 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036012 MIMAT0015028 hsa-miR-3154 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015028 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00036013 MIMAT0015032 hsa-miR-3158-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015032 hsa-miR-3158 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036014 MIMAT0015032 hsa-miR-3158-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015032 hsa-miR-3158 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036015 MIMAT0015032 hsa-miR-3158-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015032 hsa-miR-3158 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036016 MIMAT0015032 hsa-miR-3158-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015032 hsa-miR-3158 miRNA Homo sapiens 24577456 Circulating Serum Next-generation sequencing The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. Table 2 has displayed the data. RLID00036017 MIMAT0015034 hsa-miR-3160-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015034 hsa-miR-3160 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036018 MIMAT0015036 hsa-miR-3162-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015036 hsa-miR-3162 miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00036019 MIMAT0015036 hsa-miR-3162-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015036 hsa-miR-3162 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036020 MIMAT0015041 hsa-miR-1260b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015041 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036021 MIMAT0015041 hsa-miR-1260b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015041 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036022 MIMAT0015041 hsa-miR-1260b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015041 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00036023 MIMAT0015041 hsa-miR-1260b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015041 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036024 MIMAT0015041 hsa-miR-1260b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015041 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036025 MIMAT0015043 hsa-miR-3168 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015043 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036026 MIMAT0015043 hsa-miR-3168 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015043 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036027 MIMAT0015044 hsa-miR-3169 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015044 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00036028 MIMAT0015046 hsa-miR-3171 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015046 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00036029 MIMAT0015050 hsa-miR-323b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015050 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036030 MIMAT0015050 hsa-miR-323b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015050 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00036031 MIMAT0015051 hsa-miR-3174 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015051 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036032 MIMAT0015052 hsa-miR-3175 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015052 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036033 MIMAT0015053 hsa-miR-3176 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015053 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036034 MIMAT0015053 hsa-miR-3176 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015053 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00036035 MIMAT0015054 hsa-miR-3177-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015054 hsa-miR-3177 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036036 MIMAT0015054 hsa-miR-3177-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015054 hsa-miR-3177 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036037 MIMAT0015055 hsa-miR-3178 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015055 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036038 MIMAT0015058 hsa-miR-3180-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015058 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036039 MIMAT0015061 hsa-miR-3181 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015061 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036040 MIMAT0015064 hsa-miR-3184-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015064 hsa-miR-3184 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036041 MIMAT0015064 hsa-miR-3184-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015064 hsa-miR-3184 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036042 MIMAT0015064 hsa-miR-3184-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015064 hsa-miR-3184 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036043 MIMAT0015065 hsa-miR-3185 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015065 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036044 MIMAT0015065 hsa-miR-3185 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015065 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036045 MIMAT0015066 hsa-miR-3065-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015066 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036046 MIMAT0015066 hsa-miR-3065-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015066 miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00036047 MIMAT0015066 hsa-miR-3065-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015066 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036048 MIMAT0015066 hsa-miR-3065-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015066 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036049 MIMAT0015066 hsa-miR-3065-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015066 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036050 MIMAT0015070 hsa-miR-3188 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015070 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036051 MIMAT0015070 hsa-miR-3188 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015070 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036052 MIMAT0015071 hsa-miR-3189-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015071 hsa-miR-3189 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036053 MIMAT0015072 hsa-miR-320e http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015072 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036054 MIMAT0015072 hsa-miR-320e http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015072 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036055 MIMAT0015072 hsa-miR-320e http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015072 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036056 MIMAT0015073 hsa-miR-3190-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015073 "hsa-miR-3190-5p, hsa-miR-3190 " miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036057 MIMAT0015073 hsa-miR-3190-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015073 "hsa-miR-3190-5p, hsa-miR-3190 " miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00036058 MIMAT0015076 hsa-miR-3192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015076 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036059 MIMAT0015076 hsa-miR-3192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015076 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036060 MIMAT0015076 hsa-miR-3192-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015076 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036061 MIMAT0015078 hsa-miR-3194-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015078 hsa-miR-3194 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036062 MIMAT0015079 hsa-miR-3195 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015079 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036063 MIMAT0015080 hsa-miR-3196 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015080 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036064 MIMAT0015082 hsa-miR-3197 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015082 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036065 MIMAT0015082 hsa-miR-3197 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015082 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036066 MIMAT0015083 hsa-miR-3198 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015083 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036067 MIMAT0015085 hsa-miR-3200-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015085 hsa-miR-3200 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036068 MIMAT0015085 hsa-miR-3200-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015085 hsa-miR-3200 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00036069 MIMAT0015085 hsa-miR-3200-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015085 hsa-miR-3200 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036070 MIMAT0015085 hsa-miR-3200-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015085 hsa-miR-3200 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00036071 MIMAT0015086 hsa-miR-3201 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015086 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036072 MIMAT0015089 hsa-miR-3202 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015089 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036073 MIMAT0015090 hsa-miR-1273d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015090 miRNA Homo sapiens 22427800 Exosome Saliva RT-PCR The miRNAs tested in serum and saliva samples are shown in Table 1. These miRNAs were selected because they are either ubiquitously expressed or have been reported as biomarkers (Table 1). The relative concentration of these microRNAs was determined by calculating the difference of Ct values between the exosome samples and the exosome-depleted supernatant. A 1-unit difference in the Ct value between the miRNAs isolated from the exosomal pellet or supernatant represents a 2-fold difference in the amount of input miRNA. Data are collected from Table 1: List of miRNAs tested in serum and saliva samples. RLID00036074 MIMAT0015090 hsa-miR-1273d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015090 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036075 MIMAT0015210 ssc-miR-24-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015210 ssc-miR-24* miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036076 MIMAT0015211 ssc-miR-28-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015211 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036077 MIMAT0015268 ssc-miR-17-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015268 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036078 MIMAT0015269 ssc-miR-30b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015269 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036079 MIMAT0015300 ssc-miR-30a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015300 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036080 MIMAT0015369 aae-miR-92a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015369 aae-miR-92a* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00036081 MIMAT0015369 aae-miR-92a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015369 aae-miR-92a* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00036082 MIMAT0015369 aae-miR-92a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015369 aae-miR-92a* miRNA Aedes aegypti 24759922 Nucleus Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00036083 MIMAT0015371 aae-miR-1175-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015371 aae-miR-1175* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00036084 MIMAT0015371 aae-miR-1175-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015371 aae-miR-1175* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00036085 MIMAT0015372 aae-miR-263a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015372 aae-miR-263a* miRNA Aedes aegypti 24759922 Cytoplasm Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00036086 MIMAT0015372 aae-miR-263a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015372 aae-miR-263a* miRNA Aedes aegypti 24759922 Nucleus Aag2 cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00036087 MIMAT0015372 aae-miR-263a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015372 aae-miR-263a* miRNA Aedes aegypti 24759922 Cytoplasm Wolbachia-infected cell Next-generation sequencing "Globally, 71 different miRNAs in Aag2 cells were identified; 62 were detected in the nucleus and 66 in the cytoplasm (Table S1). Data are collected from Table S1. " RLID00036088 MIMAT0015375 hsv2-miR-H7-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015375 miRNA Human herpesvirus 2 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036089 MIMAT0015378 hsa-miR-3065-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015378 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036090 MIMAT0015708 ssc-miR-744 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015708 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036091 MIMAT0015709 ssc-miR-22-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015709 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036092 MIMAT0015710 ssc-miR-22-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015710 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036093 MIMAT0015711 ssc-miR-363 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015711 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036094 MIMAT0015712 ssc-miR-299 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015712 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036095 MIMAT0015713 ssc-miR-338 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0015713 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036096 MIMAT0016847 hsa-miR-378c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016847 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036097 MIMAT0016847 hsa-miR-378c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016847 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036098 MIMAT0016847 hsa-miR-378c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016847 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036099 MIMAT0016847 hsa-miR-378c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016847 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00036100 MIMAT0016847 hsa-miR-378c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016847 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036101 MIMAT0016847 hsa-miR-378c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016847 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036102 MIMAT0016847 hsa-miR-378c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016847 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036103 MIMAT0016847 hsa-miR-378c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016847 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036104 MIMAT0016847 hsa-miR-378c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016847 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036105 MIMAT0016847 hsa-miR-378c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016847 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00036106 MIMAT0016847 hsa-miR-378c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016847 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036107 MIMAT0016847 hsa-miR-378c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016847 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00036108 MIMAT0016847 hsa-miR-378c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016847 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00036109 MIMAT0016852 hsa-miR-4298 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016852 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036110 MIMAT0016858 hsa-miR-4306 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016858 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036111 MIMAT0016880 hsa-miR-4259 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016880 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036112 MIMAT0016882 hsa-miR-4253 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016882 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036113 MIMAT0016888 hsa-miR-4326 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016888 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036114 MIMAT0016895 hsa-miR-2355-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016895 hsa-miR-2355 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036115 MIMAT0016896 hsa-miR-4268 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016896 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036116 MIMAT0016896 hsa-miR-4268 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016896 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00036117 MIMAT0016900 hsa-miR-4270 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016900 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036118 MIMAT0016905 hsa-miR-4275 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016905 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00036119 MIMAT0016907 hsa-miR-4281 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016907 miRNA Homo sapiens 23539611 Microvesicle Seminal Plasma Microarray "MiRNAs shuttled by SMVs in seminal plasma are potent non-invasive biomarkers to evaluate defects originating from the different organs of the male reproductive tract, including the epididymis (Wang et al., 2011). In order to assess the reversibility of post-vasectomy miRNA sequelae, we investigated whether SMV miRNAs altered by vasectomy could be retrieved in SMVs from normospermic vasovasostomized donors. miRNA microarray profiling performed on SMVs from normal, vasectomized and vasovasostomized donors identified 313 miRNAs whose intensity was above the threshold of detection. Among these miRNAs, 293 were detected in samples from normal donors, 275 in vasectomized donors and 298 in vasovasostomized donors (Fig. 3, Supplementary data, Table SIV). Data are collected from Table S4. " RLID00036120 MIMAT0016909 hsa-miR-4279 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016909 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036121 MIMAT0016909 hsa-miR-4279 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016909 miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00036122 MIMAT0016913 hsa-miR-4285 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016913 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036123 MIMAT0016916 hsa-miR-4286 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016916 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036124 MIMAT0016916 hsa-miR-4286 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016916 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036125 MIMAT0016916 hsa-miR-4286 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016916 miRNA Homo sapiens 22849433 Extracellular vesicle HEK293T|HMEC-1|Mononuclear cell Next-generation sequencing "The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1. " RLID00036126 MIMAT0016919 hsa-miR-4292 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016919 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036127 MIMAT0016919 hsa-miR-4292 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016919 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036128 MIMAT0016921 hsa-miR-4290 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016921 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036129 MIMAT0016925 hsa-miR-500b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016925 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036130 MIMAT0016980 mmu-miR-23b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0016980 mmu-miR-23b* miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00036131 MIMAT0017006 mmu-miR-143-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017006 mmu-miR-143* miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00036132 MIMAT0017029 rno-miR-328a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017029 rno-miR-328a* miRNA Rattus norvegicus 24324399 Nucleus Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036133 MIMAT0017031 rno-miR-329-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017031 rno-miR-329* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036134 MIMAT0017035 rno-miR-337-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017035 rno-miR-337* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036135 MIMAT0017048 mmu-miR-107-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017048 mmu-miR-107* miRNA Mus musculus 17486113 Exosome Mast cell Microarray "The results showed that exosomes carry approxi-mately 121 miRNAs that have been found in all four experiments (Fig. 4 and see Supplementary Information, Table S5). Data are collected from Table S5. " RLID00036136 MIMAT0017076 mmu-miR-363-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017076 miRNA Mus musculus 23385731 Exosome Serum qRT-PCR|Microarray Supplementary Table S2 List of 27 miRNAs coincidently up-regulated in sera and primary GCs of DCKO mice. Data are collected from Table S2. RLID00036137 MIMAT0017086 rno-let-7a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017086 rno-let-7a-2* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036138 MIMAT0017109 rno-miR-93-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017109 rno-miR-93* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036139 MIMAT0017117 rno-miR-127-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017117 rno-miR-127* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036140 MIMAT0017119 rno-miR-128-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017119 rno-miR-128-2* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036141 MIMAT0017126 rno-miR-137-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017126 rno-miR-137* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036142 MIMAT0017137 rno-miR-181c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017137 rno-miR-181c* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036143 MIMAT0017184 rno-miR-365-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017184 rno-miR-365* miRNA Rattus norvegicus 24324399 Nucleus Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036144 MIMAT0017198 rno-miR-501-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017198 rno-miR-501* miRNA Rattus norvegicus 25800054 Dendrite Hippocampal and cortical neuron qRT-PCR|In situ hybridization "miR-501-3p expression is up-regulated locally in dendrites through the NMDAR subunit GluN2A, and this regulation is required for NMDA-induced suppression of GluA1 expression and long-lasting remodeling of dendritic spines. Our further analysis of miR-501-3p shows that it is increased locally in dendrites after NMDAR activation and that this up-regulation of miR-501-3p is required for NMDAR-dependent inhibition of GluA1 expression, long-lasting spine shrinkage, and elimination. These NMDA-induced changes were preserved in the CA1 neuropil of the slice in which cell bodies were removed before NMDA stimulation (Fig. 4, E-G), suggesting that miR-501-3p can repress GluA1 protein expression locally in dendrites. " RLID00036145 MIMAT0017205 rno-miR-133b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017205 rno-miR-133b* miRNA Rattus norvegicus 24324399 Nucleus Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036146 MIMAT0017226 rno-miR-505-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017226 rno-miR-505* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036147 MIMAT0017245 mmu-miR-760-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017245 miRNA Mus musculus 20733615 Mitochondrion Liver tissue Microarray Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Data are collected from Supplementary information Table S1 and Table S2. RLID00036148 MIMAT0017307 rno-miR-434-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017307 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036149 MIMAT0017308 rno-miR-455-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017308 rno-miR-455* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036150 MIMAT0017317 rno-miR-770-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017317 rno-miR-770* miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036151 MIMAT0017339 ssc-miR-199b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017339 ssc-miR-199b miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036152 MIMAT0017374 ssc-miR-143-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017374 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036153 MIMAT0017376 ssc-miR-365-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017376 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036154 MIMAT0017377 ssc-miR-92b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017377 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036155 MIMAT0017379 ssc-miR-196b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017379 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036156 MIMAT0017381 ssc-miR-339-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017381 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036157 MIMAT0017382 ssc-miR-676-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017382 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036158 MIMAT0017385 ssc-miR-1839-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017385 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036159 MIMAT0017392 hsa-miR-3200-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017392 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036160 MIMAT0017392 hsa-miR-3200-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017392 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036161 MIMAT0017811 rno-miR-344b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017811 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036162 MIMAT0017952 ssc-miR-296-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017952 ssc-miR-296 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036163 MIMAT0017955 ssc-miR-4331 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017955 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036164 MIMAT0017956 ssc-miR-382 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017956 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036165 MIMAT0017958 ssc-miR-362 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017958 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036166 MIMAT0017962 ssc-miR-4332 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017962 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036167 MIMAT0017966 ssc-miR-4334-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017966 ssc-miR-4334 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036168 MIMAT0017967 ssc-miR-1271 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017967 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036169 MIMAT0017981 hsa-miR-3605-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017981 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036170 MIMAT0017982 hsa-miR-3605-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017982 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036171 MIMAT0017982 hsa-miR-3605-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017982 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00036172 MIMAT0017985 hsa-miR-3607-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017985 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036173 MIMAT0017988 hsa-miR-3611 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017988 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036174 MIMAT0017990 hsa-miR-3613-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017990 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036175 MIMAT0017991 hsa-miR-3613-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017991 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036176 MIMAT0017991 hsa-miR-3613-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017991 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036177 MIMAT0017991 hsa-miR-3613-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017991 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036178 MIMAT0017991 hsa-miR-3613-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017991 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00036179 MIMAT0017991 hsa-miR-3613-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017991 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00036180 MIMAT0017992 hsa-miR-3614-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017992 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036181 MIMAT0017994 hsa-miR-3615 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017994 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036182 MIMAT0017994 hsa-miR-3615 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017994 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036183 MIMAT0017994 hsa-miR-3615 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017994 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036184 MIMAT0017994 hsa-miR-3615 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017994 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036185 MIMAT0017994 hsa-miR-3615 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017994 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036186 MIMAT0017994 hsa-miR-3615 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017994 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036187 MIMAT0017994 hsa-miR-3615 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017994 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00036188 MIMAT0017997 hsa-miR-3617-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0017997 hsa-miR-3617 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036189 MIMAT0018000 hsa-miR-23c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018000 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036190 MIMAT0018000 hsa-miR-23c http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018000 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036191 MIMAT0018001 hsa-miR-3620-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018001 hsa-miR-3620 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036192 MIMAT0018001 hsa-miR-3620-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018001 hsa-miR-3620 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036193 MIMAT0018065 hsa-miR-3646 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018065 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036194 MIMAT0018068 hsa-miR-3648 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018068 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036195 MIMAT0018071 hsa-miR-3651 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018071 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036196 MIMAT0018072 hsa-miR-3652 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018072 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036197 MIMAT0018073 hsa-miR-3653-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018073 hsa-miR-3653 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036198 MIMAT0018074 hsa-miR-3654 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018074 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036199 MIMAT0018074 hsa-miR-3654 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018074 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036200 MIMAT0018079 hsa-miR-1273e http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018079 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00036201 MIMAT0018083 hsa-miR-3662 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018083 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036202 MIMAT0018083 hsa-miR-3662 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018083 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036203 MIMAT0018085 hsa-miR-3663-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018085 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036204 MIMAT0018087 hsa-miR-3665 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018087 miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00036205 MIMAT0018089 hsa-miR-3667-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018089 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036206 MIMAT0018101 hsa-miR-3677-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018101 hsa-miR-3677 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036207 MIMAT0018101 hsa-miR-3677-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018101 hsa-miR-3677 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00036208 MIMAT0018104 hsa-miR-3679-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018104 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036209 MIMAT0018114 hsa-miR-3686 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018114 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036210 MIMAT0018115 hsa-miR-3687 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018115 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036211 MIMAT0018115 hsa-miR-3687 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018115 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036212 MIMAT0018119 hsa-miR-3690 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018119 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00036213 MIMAT0018182 hsa-miR-3908 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018182 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036214 MIMAT0018183 hsa-miR-3909 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018183 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036215 MIMAT0018183 hsa-miR-3909 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018183 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036216 MIMAT0018186 hsa-miR-3912-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018186 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036217 MIMAT0018189 hsa-miR-3915 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018189 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036218 MIMAT0018191 hsa-miR-3917 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018191 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036219 MIMAT0018191 hsa-miR-3917 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018191 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036220 MIMAT0018194 hsa-miR-3150b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018194 hsa-miR-3150b miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036221 MIMAT0018204 hsa-miR-676-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018204 hsa-miR-676 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036222 MIMAT0018205 hsa-miR-3928-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018205 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036223 MIMAT0018356 hsa-miR-3940-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018356 hsa-miR-3940 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036224 MIMAT0018356 hsa-miR-3940-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018356 hsa-miR-3940 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036225 MIMAT0018379 ssc-miR-149 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018379 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036226 MIMAT0018382 ssc-miR-451 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018382 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036227 MIMAT0018925 hsa-miR-1268b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018925 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036228 MIMAT0018925 hsa-miR-1268b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018925 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036229 MIMAT0018926 hsa-miR-378d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018926 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036230 MIMAT0018926 hsa-miR-378d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018926 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036231 MIMAT0018926 hsa-miR-378d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018926 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036232 MIMAT0018926 hsa-miR-378d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018926 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00036233 MIMAT0018926 hsa-miR-378d http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018926 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00036234 MIMAT0018927 hsa-miR-378e http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018927 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036235 MIMAT0018932 hsa-miR-378f http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018932 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036236 MIMAT0018932 hsa-miR-378f http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018932 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036237 MIMAT0018932 hsa-miR-378f http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018932 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00036238 MIMAT0018933 hsa-miR-4420 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018933 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036239 MIMAT0018937 hsa-miR-378g http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018937 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036240 MIMAT0018937 hsa-miR-378g http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018937 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036241 MIMAT0018937 hsa-miR-378g http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018937 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036242 MIMAT0018944 hsa-miR-4429 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018944 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036243 MIMAT0018944 hsa-miR-4429 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018944 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036244 MIMAT0018949 hsa-miR-4433a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018949 hsa-miR-4433-3p miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036245 MIMAT0018949 hsa-miR-4433a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018949 hsa-miR-4433-3p miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036246 MIMAT0018949 hsa-miR-4433a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018949 hsa-miR-4433-3p miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036247 MIMAT0018949 hsa-miR-4433a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018949 hsa-miR-4433-3p miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036248 MIMAT0018965 hsa-miR-4446-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018965 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036249 MIMAT0018965 hsa-miR-4446-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018965 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036250 MIMAT0018965 hsa-miR-4446-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018965 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036251 MIMAT0018965 hsa-miR-4446-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018965 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036252 MIMAT0018967 hsa-miR-4448 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018967 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036253 MIMAT0018967 hsa-miR-4448 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018967 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00036254 MIMAT0018968 hsa-miR-4449 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018968 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036255 MIMAT0018976 hsa-miR-4454 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018976 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036256 MIMAT0018976 hsa-miR-4454 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018976 miRNA Homo sapiens 25330373 Extracellular vesicle Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00036257 MIMAT0018980 hsa-miR-4458 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018980 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036258 MIMAT0018984 hsa-miR-378h http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018984 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036259 MIMAT0018985 hsa-miR-3135b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018985 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036260 MIMAT0018994 hsa-miR-4467 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018994 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036261 MIMAT0018994 hsa-miR-4467 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0018994 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036262 MIMAT0019000 hsa-miR-4473 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019000 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036263 MIMAT0019018 hsa-miR-4484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019018 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036264 MIMAT0019018 hsa-miR-4484 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019018 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036265 MIMAT0019022 hsa-miR-4488 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019022 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036266 MIMAT0019022 hsa-miR-4488 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019022 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036267 MIMAT0019022 hsa-miR-4488 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019022 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036268 MIMAT0019027 hsa-miR-4492 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019027 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036269 MIMAT0019032 hsa-miR-4497 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019032 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036270 MIMAT0019032 hsa-miR-4497 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019032 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036271 MIMAT0019032 hsa-miR-4497 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019032 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036272 MIMAT0019044 hsa-miR-4507 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019044 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036273 MIMAT0019045 hsa-miR-4508 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019045 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036274 MIMAT0019045 hsa-miR-4508 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019045 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036275 MIMAT0019045 hsa-miR-4508 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019045 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036276 MIMAT0019053 hsa-miR-4516 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019053 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036277 MIMAT0019054 hsa-miR-4517 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019054 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036278 MIMAT0019055 hsa-miR-4518 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019055 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036279 MIMAT0019058 hsa-miR-4521 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019058 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036280 MIMAT0019059 hsa-miR-1269b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019059 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036281 MIMAT0019064 hsa-miR-4525 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019064 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036282 MIMAT0019074 hsa-miR-378i http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019074 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036283 MIMAT0019074 hsa-miR-378i http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019074 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036284 MIMAT0019077 hsa-miR-1587 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019077 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036285 MIMAT0019198 hsa-miR-3120-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019198 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036286 MIMAT0019198 hsa-miR-3120-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019198 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036287 MIMAT0019208 hsa-miR-3074-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019208 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036288 MIMAT0019220 hsa-miR-3664-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019220 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00036289 MIMAT0019337 hsa-miR-3960 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019337 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00036290 MIMAT0019337 hsa-miR-3960 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019337 miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00036291 MIMAT0019691 hsa-miR-4634 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019691 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036292 MIMAT0019699 hsa-miR-4640-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019699 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036293 MIMAT0019708 hsa-miR-4646-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019708 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036294 MIMAT0019738 hsa-miR-4664-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019738 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00036295 MIMAT0019772 hsa-miR-4685-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019772 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036296 MIMAT0019772 hsa-miR-4685-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019772 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036297 MIMAT0019775 hsa-miR-4687-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019775 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036298 MIMAT0019776 hsa-miR-1343-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019776 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036299 MIMAT0019813 hsa-miR-203b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019813 hsa-miR-3545-5p miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036300 MIMAT0019814 hsa-miR-203b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019814 hsa-miR-3545-3p miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00036301 MIMAT0019819 hsa-miR-4712-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019819 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00036302 MIMAT0019840 hsa-miR-451b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019840 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036303 MIMAT0019844 hsa-miR-4725-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019844 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036304 MIMAT0019845 hsa-miR-4726-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019845 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00036305 MIMAT0019849 hsa-miR-4728-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019849 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036306 MIMAT0019855 hsa-miR-4732-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019855 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036307 MIMAT0019855 hsa-miR-4732-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019855 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036308 MIMAT0019855 hsa-miR-4732-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019855 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036309 MIMAT0019856 hsa-miR-4732-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019856 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036310 MIMAT0019856 hsa-miR-4732-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019856 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036311 MIMAT0019856 hsa-miR-4732-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019856 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036312 MIMAT0019856 hsa-miR-4732-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019856 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036313 MIMAT0019864 hsa-miR-3064-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019864 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036314 MIMAT0019868 hsa-miR-4739 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019868 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036315 MIMAT0019868 hsa-miR-4739 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019868 miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00036316 MIMAT0019876 hsa-miR-3591-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019876 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036317 MIMAT0019876 hsa-miR-3591-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019876 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00036318 MIMAT0019878 hsa-miR-4745-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019878 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036319 MIMAT0019885 hsa-miR-4749-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019885 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036320 MIMAT0019887 hsa-miR-4750-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019887 hsa-miR-4750 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036321 MIMAT0019903 hsa-miR-4758-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019903 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036322 MIMAT0019926 hsa-miR-4772-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019926 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036323 MIMAT0019949 hsa-miR-4785 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019949 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036324 MIMAT0019957 hsa-miR-4787-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019957 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036325 MIMAT0019964 hsa-miR-4792 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019964 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00036326 MIMAT0019965 hsa-miR-4793-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019965 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00036327 MIMAT0019966 hsa-miR-4793-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019966 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00036328 MIMAT0019976 hsa-miR-4799-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0019976 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036329 MIMAT0020362 ssc-miR-142-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020362 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036330 MIMAT0020363 ssc-miR-769-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020363 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036331 MIMAT0020366 ssc-miR-4334-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020366 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036332 MIMAT0020586 ssc-miR-129b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020586 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036333 MIMAT0020588 ssc-miR-190b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020588 ssc-miR-190 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036334 MIMAT0020590 ssc-miR-219a http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020590 ssc-miR-219 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036335 MIMAT0020591 ssc-miR-429 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020591 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036336 MIMAT0020592 ssc-miR-491 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020592 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036337 MIMAT0020596 ssc-miR-1343 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020596 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036338 MIMAT0020597 ssc-miR-2320-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020597 ssc-miR-2320 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036339 MIMAT0020598 ssc-miR-2320-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020598 ssc-miR-2320* miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036340 MIMAT0020601 hsa-miR-1273f http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020601 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036341 MIMAT0020602 hsa-miR-1273g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020602 hsa-miR-1273g miRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00036342 MIMAT0020925 hsa-miR-550a-3-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020925 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00036343 MIMAT0020956 hsa-miR-4433a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020956 hsa-miR-4433-5p miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036344 MIMAT0020956 hsa-miR-4433a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0020956 hsa-miR-4433-5p miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036345 MIMAT0021021 hsa-miR-5001-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0021021 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036346 MIMAT0021044 hsa-miR-5010-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0021044 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036347 MIMAT0021044 hsa-miR-5010-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0021044 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036348 MIMAT0021120 hsa-miR-5189-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0021120 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036349 MIMAT0021120 hsa-miR-5189-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0021120 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036350 MIMAT0022255 hsa-miR-4524b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022255 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00036351 MIMAT0022260 hsa-miR-5572 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022260 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036352 MIMAT0022265 hsa-miR-548ar-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022265 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036353 MIMAT0022272 hsa-miR-664b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022272 hsa-miR-644b-3p miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036354 MIMAT0022286 hsa-miR-5585-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022286 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00036355 MIMAT0022303 hsa-miR-548av-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022303 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036356 MIMAT0022491 hsa-miR-5698 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022491 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036357 MIMAT0022494 hsa-miR-5701 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022494 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036358 MIMAT0022692 hsa-miR-181b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022692 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036359 MIMAT0022692 hsa-miR-181b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022692 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00036360 MIMAT0022692 hsa-miR-181b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022692 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In contrast to oncomirs, an miRNA that is involved in tumor-suppressing activities, is taken as a tumor suppressor (oncosuppressor). The aberrantly expressed miR-223, which directly targeted Stathmin 1 to inhibit HCC growth, was only found in MVs of liver cancer cell line in our study (table 2). Data are collected from Table 2. " RLID00036361 MIMAT0022693 hsa-miR-204-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022693 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036362 MIMAT0022693 hsa-miR-204-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022693 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036363 MIMAT0022695 hsa-miR-212-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022695 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00036364 MIMAT0022695 hsa-miR-212-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022695 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036365 MIMAT0022696 hsa-miR-301a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022696 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036366 MIMAT0022697 hsa-miR-382-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022697 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 1: Ten miRNAs differentially expressed in both tumor tissue and serum. Data are collected from Table 1. RLID00036367 MIMAT0022697 hsa-miR-382-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022697 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036368 MIMAT0022698 hsa-miR-345-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022698 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036369 MIMAT0022700 hsa-miR-450a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022700 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036370 MIMAT0022700 hsa-miR-450a-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022700 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036371 MIMAT0022705 hsa-miR-539-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022705 miRNA Homo sapiens 24904649 Circulating Serum Next-generation sequencing Table 2: Inconsistent expression change of 28 miRNAs between tumor tissue and serum. Data are collected from Table 2. RLID00036372 MIMAT0022705 hsa-miR-539-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022705 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036373 MIMAT0022705 hsa-miR-539-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022705 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036374 MIMAT0022708 hsa-miR-584-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022708 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036375 MIMAT0022708 hsa-miR-584-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022708 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036376 MIMAT0022709 hsa-miR-652-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022709 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036377 MIMAT0022711 hsa-miR-660-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022711 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036378 MIMAT0022711 hsa-miR-660-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022711 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036379 MIMAT0022717 hsa-miR-873-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022717 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036380 MIMAT0022717 hsa-miR-873-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022717 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036381 MIMAT0022717 hsa-miR-873-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022717 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036382 MIMAT0022717 hsa-miR-873-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022717 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036383 MIMAT0022717 hsa-miR-873-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022717 miRNA Homo sapiens 24797360 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 Table 1: Differentially expressed miRNAs detected in the cerebrospinal fluid (CSF). Data are collected from Table 1. RLID00036384 MIMAT0022717 hsa-miR-873-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022717 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00036385 MIMAT0022720 hsa-miR-1304-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022720 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036386 MIMAT0022720 hsa-miR-1304-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022720 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036387 MIMAT0022722 hsa-miR-548g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022722 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036388 MIMAT0022724 hsa-miR-1277-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022724 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036389 MIMAT0022725 hsa-miR-1255b-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022725 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00036390 MIMAT0022726 hsa-miR-1306-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022726 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036391 MIMAT0022726 hsa-miR-1306-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022726 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036392 MIMAT0022726 hsa-miR-1306-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022726 miRNA Homo sapiens 25349172 Exosome Serum Next-generation sequencing "Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. " RLID00036393 MIMAT0022726 hsa-miR-1306-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022726 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036394 MIMAT0022726 hsa-miR-1306-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022726 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036395 MIMAT0022727 hsa-miR-1307-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022727 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036396 MIMAT0022727 hsa-miR-1307-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022727 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036397 MIMAT0022727 hsa-miR-1307-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022727 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036398 MIMAT0022727 hsa-miR-1307-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022727 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036399 MIMAT0022727 hsa-miR-1307-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022727 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00036400 MIMAT0022727 hsa-miR-1307-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022727 miRNA Homo sapiens 24797360 Microvesicle Serum RNA-seq|miRDeep3 Table 2: Differentially expressed miRNAs detected in the serum (SER). Data are collected from Table 2. RLID00036401 MIMAT0022731 hsa-miR-3184-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022731 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036402 MIMAT0022731 hsa-miR-3184-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022731 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036403 MIMAT0022733 hsa-miR-548x-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022733 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036404 MIMAT0022735 hsa-miR-374c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022735 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036405 MIMAT0022735 hsa-miR-374c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022735 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036406 MIMAT0022737 hsa-miR-550b-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022737 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036407 MIMAT0022737 hsa-miR-550b-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022737 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036408 MIMAT0022739 hsa-miR-548aj-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022739 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036409 MIMAT0022741 hsa-miR-3529-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022741 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036410 MIMAT0022741 hsa-miR-3529-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022741 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036411 MIMAT0022741 hsa-miR-3529-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022741 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036412 MIMAT0022742 hsa-miR-1273g-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022742 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036413 MIMAT0022742 hsa-miR-1273g-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022742 miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00036414 MIMAT0022833 hsa-miR-365b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022833 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036415 MIMAT0022834 hsa-miR-365b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022834 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036416 MIMAT0022834 hsa-miR-365b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022834 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036417 MIMAT0022834 hsa-miR-365b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022834 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036418 MIMAT0022834 hsa-miR-365b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022834 miRNA Homo sapiens 25330373 Exosome Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00036419 MIMAT0022834 hsa-miR-365b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022834 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036420 MIMAT0022834 hsa-miR-365b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022834 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036421 MIMAT0022838 hsa-miR-1185-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022838 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036422 MIMAT0022838 hsa-miR-1185-1-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022838 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036423 MIMAT0022842 hsa-miR-98-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022842 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00036424 MIMAT0022842 hsa-miR-98-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022842 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00036425 MIMAT0022842 hsa-miR-98-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022842 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036426 MIMAT0022842 hsa-miR-98-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022842 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036427 MIMAT0022844 hsa-miR-216a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022844 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036428 MIMAT0022862 hsa-miR-381-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022862 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036429 MIMAT0022924 hsa-miR-495-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022924 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036430 MIMAT0022929 hsa-miR-758-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022929 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036431 MIMAT0022947 hsa-miR-1238-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022947 miRNA Homo sapiens 23771658 Microvesicle Hepatoma cell qRT-PCR|Microarray "In line with the difference in number of detectable miRNAs, the expression levels of these miRNAs also varied between MVs and cells. Statistical analysis of the 148 co-expressing miRNAs showed that 25 miRNAs were aberrantly elevated inMVs and 75 miRNAs were significantly elevated in cells with more than two folds change. Forty-eight miRNAs had the similar signal intensity in both groups (table 1). Data are collected from Table 1. " RLID00036432 MIMAT0022957 ssc-miR-455-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022957 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036433 MIMAT0022967 hsa-miR-3620-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0022967 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036434 MIMAT0023712 hsa-miR-6087 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0023712 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00036435 MIMAT0023712 hsa-miR-6087 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0023712 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036436 MIMAT0023712 hsa-miR-6087 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0023712 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036437 MIMAT0024615 hsa-miR-6131 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0024615 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036438 MIMAT0024616 hsa-miR-6132 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0024616 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036439 MIMAT0025356 ssc-let-7d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0025356 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036440 MIMAT0025357 ssc-let-7d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0025357 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036441 MIMAT0025359 ssc-miR-20b http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0025359 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036442 MIMAT0025483 hsa-miR-6513-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0025483 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036443 MIMAT0025487 hsa-miR-6515-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0025487 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036444 MIMAT0025487 hsa-miR-6515-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0025487 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036445 MIMAT0025846 hsa-miR-6717-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0025846 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036446 MIMAT0025853 hsa-miR-6722-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0025853 miRNA Homo sapiens 24683445 Exosome Plasma Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036447 MIMAT0025854 hsa-miR-6722-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0025854 miRNA Homo sapiens 24867291 Circulating Aqueous humor Microarray "There are three sources of extracellular miRNAs in the eye: tears, the vitreous humor, and the aqueous humor (AH). A receiver operating characteristic (ROC) analysis of the 11 up-regulated and 18 down-regulated miRNAs showed that they all had an area under the curve (AUC) greater than 0.74 (Figure 3b, c, and d). A hierarchal cluster analysis with these 29 miRNA markers showed a cluster composed only of glaucoma patients was formed (Figure 4). Data are collected from Figure 4: Cluster analysis of selected 29 miRNA markers for glaucoma. " RLID00036448 MIMAT0026467 rno-miR-125b-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026467 miRNA Rattus norvegicus 24324399 Cytoplasm Cortical cell|Hippocampal neuron Microarray "To determine expression levels of nuclear and cytoplasmic mature miRNAs, size-selected small RNA samples (3 nuclear and 3 cytoplasmic samples) were analyzed by miRNA microarrays (LCSciences), containing probes for 679 rat mature miRNAs (miRBase version 16). In total, we were able to detect 267 mature miRNAs which were common to both nucleus and cytoplasm (Table S1). Data are collected from Table S1. " RLID00036449 MIMAT0026472 hsa-let-7c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026472 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036450 MIMAT0026472 hsa-let-7c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026472 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036451 MIMAT0026472 hsa-let-7c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026472 miRNA Homo sapiens 21695135 Cytoplasm HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00036452 MIMAT0026472 hsa-let-7c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026472 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00036453 MIMAT0026472 hsa-let-7c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026472 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036454 MIMAT0026472 hsa-let-7c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026472 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036455 MIMAT0026472 hsa-let-7c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026472 miRNA Homo sapiens 25184951 Exosome Esophageal cancer cell Next-generation sequencing "All known miRNAs in exosomes were detected at lower levels compared with their corresponding cells, whereas several novel miRNAs in exosomes were detected at higher levels compared with their corresponding cells. Data are collected from Table 3. " RLID00036456 MIMAT0026472 hsa-let-7c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026472 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00036457 MIMAT0026472 hsa-let-7c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026472 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036458 MIMAT0026472 hsa-let-7c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026472 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036459 MIMAT0026472 hsa-let-7c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026472 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036460 MIMAT0026472 hsa-let-7c-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026472 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00036461 MIMAT0026473 hsa-miR-95-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026473 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00036462 MIMAT0026473 hsa-miR-95-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026473 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036463 MIMAT0026473 hsa-miR-95-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026473 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00036464 MIMAT0026473 hsa-miR-95-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026473 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036465 MIMAT0026473 hsa-miR-95-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026473 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036466 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036467 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036468 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036469 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 24212760 Circulating Serum qRT-PCR "Therefore, we investigated whether serum miR-210 could be a useful biomarker for the diagnosis and progression of CCC. " RLID00036470 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00036471 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 19289371 Exosome Plasma Microarray Figure 1: Intensities for specific microRNAs derived from the tumor and exosomes isolated from the plasma of the patients. Data are collected from Figure 1. RLID00036472 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00036473 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00036474 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036475 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036476 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 25017274 Circulating Serum qRT-PCR "The expression of four miRNAs (miR-1233, miR-520, miR-210, miR-144) was validated by quantitative real-time polymerase chain reaction analysis. MiR-1233 was the most overexpressed in the serum of women who later developed sPE. Circulating miRNAs deserve further investigation in order to explore their potential role in the pathogenesis of preeclampsia. In particular, miR-1233 might represent a potential marker of early sPE. " RLID00036477 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00036478 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036479 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036480 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 20864815 Nucleus Colon adenocarcinoma cell Microarray Table 2: Reported gene targets of nuclear-associated microRNAs. Data are collected from Table 2. RLID00036481 MIMAT0026475 hsa-miR-210-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026475 miRNA Homo sapiens 21363885 Nucleus Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00036482 MIMAT0026476 hsa-miR-215-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026476 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036483 MIMAT0026476 hsa-miR-215-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026476 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036484 MIMAT0026476 hsa-miR-215-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026476 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036485 MIMAT0026476 hsa-miR-215-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026476 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036486 MIMAT0026476 hsa-miR-215-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026476 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036487 MIMAT0026476 hsa-miR-215-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026476 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00036488 MIMAT0026477 hsa-miR-128-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026477 miRNA Homo sapiens 21363885 Cytoplasm Neural progenitor cell qRT-PCR|Microarray The miRNAs with nuclear or cytoplasmic dominance are shown in Table 1 (complete data in Supplement 4). RLID00036489 MIMAT0026477 hsa-miR-128-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026477 miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00036490 MIMAT0026477 hsa-miR-128-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026477 miRNA Homo sapiens 20976003 Exosome Breast cancer cell Microarray "Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. " RLID00036491 MIMAT0026477 hsa-miR-128-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026477 miRNA Homo sapiens 21505438 Exosome Dendritic cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00036492 MIMAT0026477 hsa-miR-128-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026477 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00036493 MIMAT0026477 hsa-miR-128-1-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026477 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036494 MIMAT0026478 hsa-miR-133a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026478 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036495 MIMAT0026478 hsa-miR-133a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026478 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036496 MIMAT0026478 hsa-miR-133a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026478 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00036497 MIMAT0026478 hsa-miR-133a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026478 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00036498 MIMAT0026478 hsa-miR-133a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026478 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036499 MIMAT0026478 hsa-miR-133a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026478 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036500 MIMAT0026478 hsa-miR-133a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026478 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036501 MIMAT0026479 hsa-miR-152-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026479 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036502 MIMAT0026479 hsa-miR-152-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026479 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036503 MIMAT0026479 hsa-miR-152-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026479 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00036504 MIMAT0026479 hsa-miR-152-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026479 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00036505 MIMAT0026479 hsa-miR-152-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026479 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036506 MIMAT0026479 hsa-miR-152-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026479 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036507 MIMAT0026479 hsa-miR-152-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026479 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036508 MIMAT0026479 hsa-miR-152-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026479 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036509 MIMAT0026480 hsa-miR-153-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026480 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036510 MIMAT0026480 hsa-miR-153-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026480 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036511 MIMAT0026481 hsa-miR-134-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026481 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036512 MIMAT0026481 hsa-miR-134-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026481 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036513 MIMAT0026481 hsa-miR-134-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026481 miRNA Homo sapiens 21505438 Exosome T cell Microarray Supplementary Data 1: Microarray analysis of exosomal miRNAs verses the miRNAs of their respective donor cells. Data are collected from Supplementary Data 1. RLID00036514 MIMAT0026481 hsa-miR-134-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026481 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036515 MIMAT0026481 hsa-miR-134-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026481 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036516 MIMAT0026481 hsa-miR-134-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026481 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00036517 MIMAT0026481 hsa-miR-134-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026481 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00036518 MIMAT0026481 hsa-miR-134-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026481 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00036519 MIMAT0026483 hsa-miR-370-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026483 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00036520 MIMAT0026483 hsa-miR-370-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026483 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036521 MIMAT0026483 hsa-miR-370-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026483 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036522 MIMAT0026483 hsa-miR-370-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026483 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00036523 MIMAT0026483 hsa-miR-370-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026483 miRNA Homo sapiens 22529849 Exosome Ovarian tumor cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00036524 MIMAT0026484 hsa-miR-372-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026484 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036525 MIMAT0026484 hsa-miR-372-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026484 miRNA Homo sapiens 25415674 Circulating Plasma Next-generation sequencing "To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2. " RLID00036526 MIMAT0026484 hsa-miR-372-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026484 miRNA Homo sapiens 24918059 Nucleolus HeLa|MCF7 Microarray Data are collected from supplementary Table S1.Top-ranking nucleolar miRNAs present in HeLa and MCF7 NCode arrays. RLID00036527 MIMAT0026485 hsa-miR-383-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026485 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036528 MIMAT0026485 hsa-miR-383-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026485 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036529 MIMAT0026486 hsa-miR-328-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026486 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036530 MIMAT0026486 hsa-miR-328-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026486 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036531 MIMAT0026486 hsa-miR-328-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026486 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036532 MIMAT0026486 hsa-miR-328-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026486 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00036533 MIMAT0026486 hsa-miR-328-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026486 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036534 MIMAT0026486 hsa-miR-328-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026486 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036535 MIMAT0026486 hsa-miR-328-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026486 miRNA Homo sapiens 24468161 Exosome Breast cancer cell RT-PCR|Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00036536 MIMAT0026486 hsa-miR-328-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026486 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00036537 MIMAT0026486 hsa-miR-328-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026486 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036538 MIMAT0026486 hsa-miR-328-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026486 miRNA Homo sapiens 22529849 Exosome PBMC - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00036539 MIMAT0026552 hcmv-miR-UL112-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026552 miRNA Human herpesvirus 5 21690488 Circulating Plasma qRT-PCR "The expressions of selected miRNAs (miR-296-5p, let-7e, and a human cytomegalovirus [HCMV]-encoded miRNA, hcmv-miR-UL112) were validated independently in plasma samples from 24 hypertensive patients and 22 control subjects. " RLID00036540 MIMAT0026552 hcmv-miR-UL112-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026552 miRNA Human herpesvirus 5 21924071 Circulating Plasma Microarray "MiR-296-5p (Fold change 0.47, P = 0.013) and miR-133b (Fold change 0.57, P = 0.033) were consistently down-regulated in the patient plasma, whereas let-7e (Fold change 1.62, P = 0.009) and hcmv-miR-UL112 (Fold change 2.72, P = 0.004), one human cytomegalovirus encoded microRNAs, were up-regulated in the patient samples. " RLID00036541 MIMAT0026554 hsa-miR-433-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026554 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036542 MIMAT0026554 hsa-miR-433-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026554 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036543 MIMAT0026554 hsa-miR-433-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026554 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00036544 MIMAT0026554 hsa-miR-433-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026554 miRNA Homo sapiens 25323050 Circulating serum Next-generation sequencing "Twenty seven candidate microRNAs were screened out from ONFH serum. Fifteen microRNAs, including miR-423-5p, miR-3960, miR-195-5p, miR-15b-3p and miR-1304-3p, were over-expressed. Twelve microRNAs, including miR-100-5p, miR-99a-5p, miR-532-5p, miR-140-5p, miR-10a-5p, miR-10b-5p, miR-181c-5p and miR-433, were under-expressed in ONFH serum compared with SLE controls and healthy controls (Fig. 3). Data are collected from Figure 3. " RLID00036545 MIMAT0026554 hsa-miR-433-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026554 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036546 MIMAT0026555 hsa-miR-329-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026555 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036547 MIMAT0026555 hsa-miR-329-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026555 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036548 MIMAT0026557 hsa-miR-412-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026557 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036549 MIMAT0026557 hsa-miR-412-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026557 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036550 MIMAT0026558 hsa-miR-410-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026558 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036551 MIMAT0026558 hsa-miR-410-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026558 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036552 MIMAT0026558 hsa-miR-410-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026558 miRNA Homo sapiens 23666971 Circulating Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00036553 MIMAT0026558 hsa-miR-410-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026558 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036554 MIMAT0026558 hsa-miR-410-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026558 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036555 MIMAT0026558 hsa-miR-410-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026558 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00036556 MIMAT0026558 hsa-miR-410-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026558 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00036557 MIMAT0026559 hsa-miR-487a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026559 miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00036558 MIMAT0026559 hsa-miR-487a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026559 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036559 MIMAT0026605 hsa-miR-489-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026605 miRNA Homo sapiens 25126405 Circulating Serum qRT-PCR "Circulating miRNAs in the serum and plasma are remarkably stable and are suggested to have promise as noninvasive biomarkers for neurological and neurodevelopmental disorders. Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated. " RLID00036560 MIMAT0026605 hsa-miR-489-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026605 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036561 MIMAT0026606 hsa-miR-511-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026606 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036562 MIMAT0026607 hsa-miR-494-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026607 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00036563 MIMAT0026607 hsa-miR-494-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026607 miRNA Homo sapiens 23666971 Microvesicle Follicular fluid Microarray "The TaqMan miRNA Array Card version 3.0, which includes 766 mature miRNAs, detected the presence of miRNAs in both the microvesicles and the supernatant. A total of 120 miRNAs (cycle threshold [Ct] <37) were found in the in microvesicles extracted from 8 mL fresh follicular fluid, and 82 miRNAs (Ct <37) were expressed in 500 uL supernatant (Table 2). Data are collected from Table 2. " RLID00036564 MIMAT0026607 hsa-miR-494-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026607 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell RT-PCR|Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00036565 MIMAT0026608 hsa-miR-181d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026608 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036566 MIMAT0026608 hsa-miR-181d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026608 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036567 MIMAT0026608 hsa-miR-181d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026608 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036568 MIMAT0026608 hsa-miR-181d-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026608 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036569 MIMAT0026610 hsa-miR-519d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026610 miRNA Homo sapiens 20729298 Circulating Plasma RT-PCR Table 1. List of pregnancy-associated miRNAs in maternal plasma. Data are collected from Table 1. RLID00036570 MIMAT0026610 hsa-miR-519d-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026610 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036571 MIMAT0026611 hsa-miR-520g-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026611 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036572 MIMAT0026612 hsa-miR-504-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026612 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036573 MIMAT0026612 hsa-miR-504-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026612 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036574 MIMAT0026612 hsa-miR-504-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026612 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036575 MIMAT0026613 hsa-miR-510-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026613 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036576 MIMAT0026614 hsa-miR-487b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026614 miRNA Homo sapiens 25405200 Circulating Serum qRT-PCR "Individual qRT-PCR results (expression level) of serum miRNA expression in macrosomia and controls is shown in Table 3, including has-miR-122, has-miR-192, has-miR-194, has-miR-296-5p, has-miR-376a, has-miR-487b, has-miR-505, has-miR-1262 " RLID00036577 MIMAT0026614 hsa-miR-487b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026614 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00036578 MIMAT0026614 hsa-miR-487b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026614 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036579 MIMAT0026614 hsa-miR-487b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026614 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036580 MIMAT0026616 hsa-miR-579-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026616 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036581 MIMAT0026616 hsa-miR-579-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026616 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036582 MIMAT0026616 hsa-miR-579-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026616 miRNA Homo sapiens 20615901 Microvesicle A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00036583 MIMAT0026616 hsa-miR-579-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026616 miRNA Homo sapiens 20615901 Exosome A549|HepG2 Microarrays|RT-PCR "These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. " RLID00036584 MIMAT0026616 hsa-miR-579-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026616 miRNA Homo sapiens 22529849 Exosome Epithelial cell - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00036585 MIMAT0026617 hsa-miR-580-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026617 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036586 MIMAT0026618 hsa-miR-585-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026618 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036587 MIMAT0026620 hsa-miR-598-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026620 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036588 MIMAT0026620 hsa-miR-598-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026620 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036589 MIMAT0026622 hsa-miR-619-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026622 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036590 MIMAT0026623 hsa-miR-627-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026623 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036591 MIMAT0026623 hsa-miR-627-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026623 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00036592 MIMAT0026624 hsa-miR-651-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026624 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036593 MIMAT0026624 hsa-miR-651-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026624 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036594 MIMAT0026626 hsa-miR-655-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026626 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036595 MIMAT0026627 hsa-miR-656-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026627 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036596 MIMAT0026627 hsa-miR-656-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026627 miRNA Homo sapiens 24683445 Exosome Serum Next-generation sequencing "Exosomes are enriched with miRNA: Small RNA libraries of the samples described above were constructed for small RNA-seq by NGS. The number of miRNA identified in this study was 943 of 2,233 known mature miRNA from miRBase V.20. Mapping to Ensembl Release 74 was performed to identify other non-coding RNA such as tRNA, rRNA, small nucleolar RNA (snoRNA) and LincRNA. The average across all 3 samples was calculated to obtain a representative profile of biological diversity between patients (standard deviations of reads in Supplementary file) " RLID00036597 MIMAT0026637 hsa-miR-1296-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026637 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036598 MIMAT0026637 hsa-miR-1296-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026637 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00036599 MIMAT0026637 hsa-miR-1296-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026637 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036600 MIMAT0026638 hsa-miR-1468-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026638 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036601 MIMAT0026639 hsa-miR-1301-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026639 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036602 MIMAT0026639 hsa-miR-1301-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026639 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036603 MIMAT0026639 hsa-miR-1301-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026639 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036604 MIMAT0026641 hsa-miR-1298-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026641 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036605 MIMAT0026641 hsa-miR-1298-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026641 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036606 MIMAT0026641 hsa-miR-1298-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026641 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00036607 MIMAT0026717 hsa-miR-891a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026717 miRNA Homo sapiens 20145944 Circulating Semen RT-PCR|Microarray "Our results highlight four miRNA markers for blood identification (miR-20a, miR-106a, miR-185, and miR-144) and five for semen identification (miR-135a, miR-10a, miR-507, miR-943, and miR-891a). Of those, two miRNA markers for blood (miR-144 and miR-185) and two others for semen (miR-135a and miR-897a) are suggestive to be most useful for body fluid identification in future forensic applications, and the respective RT-PCR assays used here for their detection were highly sensitive, allowing the reliable marker detection from subpicogram amounts of total RNA. Our results proved the applicability of the miRNA approach for forensic body fluids identification. " RLID00036608 MIMAT0026717 hsa-miR-891a-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026717 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036609 MIMAT0026718 hsa-miR-874-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026718 miRNA Homo sapiens 22262318 Circulating Plasma qRT-PCR Table 1: The miRNAs the level of which were markedly decreased in post-operative plasma. Data are collected from Table 1. RLID00036610 MIMAT0026718 hsa-miR-874-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026718 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036611 MIMAT0026718 hsa-miR-874-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026718 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036612 MIMAT0026718 hsa-miR-874-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026718 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036613 MIMAT0026718 hsa-miR-874-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026718 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036614 MIMAT0026719 hsa-miR-889-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026719 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036615 MIMAT0026719 hsa-miR-889-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026719 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036616 MIMAT0026719 hsa-miR-889-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026719 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00036617 MIMAT0026721 hsa-miR-216b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026721 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036618 MIMAT0026721 hsa-miR-216b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026721 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036619 MIMAT0026722 hsa-miR-208b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026722 miRNA Homo sapiens 20145944 Circulating Saliva RT-PCR|Microarray "Also the miRNAs, miR-583, miR-518c*, and miR-208b identified by microarray analysis as candidate markers for saliva and miR-617 for vaginal secretion, demonstrated a strong discordance between microarray and TaqMan data (Electronic supplementary materials, Fig. 2). " RLID00036620 MIMAT0026722 hsa-miR-208b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026722 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036621 MIMAT0026722 hsa-miR-208b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026722 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S1. The expression profiles of serum miRNAs in non-survivors of sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S1. RLID00036622 MIMAT0026734 hsa-miR-942-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026734 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036623 MIMAT0026734 hsa-miR-942-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026734 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036624 MIMAT0026735 hsa-miR-1180-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026735 miRNA Homo sapiens 23525801 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036625 MIMAT0026735 hsa-miR-1180-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026735 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036626 MIMAT0026735 hsa-miR-1180-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026735 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036627 MIMAT0026735 hsa-miR-1180-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026735 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036628 MIMAT0026735 hsa-miR-1180-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026735 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036629 MIMAT0026736 hsa-miR-548e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026736 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036630 MIMAT0026736 hsa-miR-548e-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026736 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036631 MIMAT0026737 hsa-miR-548j-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026737 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036632 MIMAT0026738 hsa-miR-1287-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026738 miRNA Homo sapiens 23525801 Circulating Serum Next-generation sequencing|RT-PCR "Next, we wanted to compare the miRNA identified in serum to miRNA present in CSF from the same subjects. We examined the miRNA profiles for five different subjects from whom both CSF and serum were collected (Supplemental Table 4). Data are collected from Table S4. " RLID00036633 MIMAT0026740 hsa-miR-1250-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026740 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036634 MIMAT0026740 hsa-miR-1250-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026740 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036635 MIMAT0026740 hsa-miR-1250-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026740 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00036636 MIMAT0026741 hsa-miR-1251-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026741 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036637 MIMAT0026742 hsa-miR-1266-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026742 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036638 MIMAT0026916 hsa-miR-1908-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026916 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036639 MIMAT0026916 hsa-miR-1908-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026916 miRNA Homo sapiens 19627513 Exosome Saliva Microarray "For a more comprehensive assessment of exosomal miRNAs we ran two miRNA microarrays: one microarray was hybridized with microRNAs from parotid saliva against microRNAs from submandibular saliva from the same normal volunteer, and the second microarray was hybridized with miRNAs from parotid saliva from a normal volunteer against miRNAs from a Sjogren's syndrome patient saliva sample (Table 1). Data are collected from Table 1: list of the most highly expressed human microRNAs in parotid exosomes. " RLID00036640 MIMAT0026916 hsa-miR-1908-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026916 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036641 MIMAT0026916 hsa-miR-1908-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026916 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036642 MIMAT0026916 hsa-miR-1908-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026916 miRNA Homo sapiens 24468161 Exosome Breast cancer cell Microarray "Figure 3: Differential gene expression in exosome-like vesicles. A) Hierarchical clustering was used to display miRNAs differentially expressed in each vesicle type. The extent of green (decreased fold change) or red (increased fold change) colors is directly proportional to the magnitude of differential expression of miRNAs. To perform these comparisons, probe sets whose target was not detected in any sample were eliminated from the data matrix. The data were grouped by type of exosome-like vesicles and members of each group were pooled, before a Student's t-test was used to identify those miRNAs that were expressed in a statistically significant manner (P < 0.05). B) miRNA profiles of the MDA-Exo versus MCF-Exo. Bars represent fold change of hybridization signals in MDA-Exo against MCF-Exo. Blue and red bars display relatively higher miRNA expressions in MDA-Exo and MCF-Exo, respectively. The miRNAs were quantified using the universal reference in equimolar concentrations and cross referenced with experimental data. Then the expression values were compared in two types of exosome-like vesicles (three independent experiments; P < 0.05). Data are collected from Figure 3. " RLID00036643 MIMAT0026916 hsa-miR-1908-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026916 miRNA Homo sapiens 21695135 Mitochondrion HeLa cell Microarray "While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5. " RLID00036644 MIMAT0026916 hsa-miR-1908-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026916 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036645 MIMAT0026916 hsa-miR-1908-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026916 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036646 MIMAT0026916 hsa-miR-1908-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0026916 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036647 MIMAT0027027 hsa-miR-3192-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0027027 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036648 MIMAT0027027 hsa-miR-3192-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0027027 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036649 MIMAT0027027 hsa-miR-3192-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0027027 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036650 MIMAT0027027 hsa-miR-3192-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0027027 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036651 MIMAT0027032 hsa-miR-500b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0027032 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036652 MIMAT0027037 hsa-miR-3928-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0027037 miRNA Homo sapiens 23641832 Circulating Serum Next-generation sequencing Additional file 2: Expression profile of serum miRNAs in pooled sera from healthy controls and AMI patients by solexa sequencing technology. Data are collected from Additional file 2. RLID00036653 MIMAT0027037 hsa-miR-3928-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0027037 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036654 MIMAT0027037 hsa-miR-3928-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0027037 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036655 MIMAT0027037 hsa-miR-3928-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0027037 miRNA Homo sapiens 22719975 Circulating Serum Next-generation sequencing Table S2: Expression profiles of serum miRNAs in surviving sepsis patients (n=9) detected by Solexa sequencing. Data are collected from Table S2. RLID00036656 MIMAT0027038 hsa-miR-1343-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0027038 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036657 MIMAT0027088 hsa-miR-5189-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0027088 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036658 MIMAT0027621 hsa-miR-6769b-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0027621 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036659 MIMAT0028143 ssc-miR-7134-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0028143 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036660 MIMAT0028144 ssc-miR-7134-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0028144 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036661 MIMAT0028149 ssc-miR-7137-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0028149 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036662 MIMAT0028150 ssc-miR-7137-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0028150 miRNA Sus scrofa 24499489 Exosome Milk Next-generation sequencing "In this study, exosomes of approximately 100 nm in diameter were isolated from porcine milk through serial centrifugation and ultracentrifugation procedures. Total RNA was extracted from exosomes, and 5S ribosomal RNA was found to be the major RNA component. Solexa sequencing showed a total of 491 miRNAs, including 176 known miRNAs and 315 novel mature miRNAs (representing 366 pre-miRNAs), which were distributed among 30 clusters and 35 families, and two predicted novel miRNAs were verified targeting 3'UTR of IGF-1R by luciferase assay. Interestingly, we observed that three miRNAs (ssc-let-7e, ssc-miR-27a, and ssc-miR-30a) could be generated from miRNA-offset RNAs (moRNAs). Data are collected from Additional file. " RLID00036663 MIMAT0029782 hsa-miR-7641 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0029782 miRNA Homo sapiens 25330373 Extracellular vesicle Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00036664 MIMAT0029894 mmu-miR-126b-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0029894 miRNA Mus musculus 22965126 Exosome Neuronal cell Microarray "In exosome preparations isolated from the same cells, we detected 157 (42%) specific miRNAs in both uninfected and prion-infected exosomes (Figure 2B and Supplementary Table S2). Data are collected from Table S2. " RLID00036665 MIMAT0030019 hsa-miR-7704 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0030019 miRNA Homo sapiens 25330373 Microvesicle Colon Cancer Cell Line qRT-PCR|RNA-seq "To assess whether some miRNAs are specifically sorted into EVs we conducted a miRNA-enrichment analysis for A33-Exos, EpCAM-Exos and sMVs. MiRNAs with <2 fold changes relative to CL miRNAs were filtered out, yielding 63 miRNAs for comparison (Table 2). Data are collected from Table 2. " RLID00036666 MIMAT0031074 hsa-miR-450a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0031074 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036667 MIMAT0031074 hsa-miR-450a-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0031074 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036668 MIMAT0031095 hsa-miR-128-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0031095 miRNA Homo sapiens 18589210 Exosome Serum Microarray Table 1:Association of microRNA with peripheral blood-derived tumor exosomes compared with microRNA isolated from their corresponding tumors. Data are collected from Table 1. RLID00036669 MIMAT0031095 hsa-miR-128-2-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0031095 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036670 MIMAT0031177 hsa-miR-7974 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0031177 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036671 MIMAT0031178 hsa-miR-7975 http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0031178 miRNA Homo sapiens 25242326 Exosome B cell Next-generation sequencing "Although the miRNA distribution in exosomal fractions is clearly influenced by cellular miRNA abundance, we identified a subset of miRNAs that were discordantly distributed between cells and exosomes (false discovery rate [FDR] < 0.05; Tables S1B and S1C). " RLID00036672 MIMAT0031890 hsa-miR-203a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0031890 miRNA Homo sapiens 22211110 Exosome Breast milk Next-generation sequencing "Reads from mRNA and ribosome footprinting libraries were then remapped to this subset of mRNAs, allowing each read to map to two locations, allowing two mismatches in a 25-nt seed region, and enabling the best and strata options. Mapping details are provided in supplemental Table S1 with abundance and ribosome loading of each mRNA specified in supplemental Table S2. Data are collected from Table S2. " RLID00036673 MIMAT0031890 hsa-miR-203a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0031890 miRNA Homo sapiens 23382797 Exosome Brain tissue Microarray "We performed miRNA expression analysis using a FlexMAP3D instrument by (Luminex Corporation, Austin, TX) and a manufacturer's assay for 312 miRNA (Table S1). Data are collected from Table S1. " RLID00036674 MIMAT0031890 hsa-miR-203a-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0031890 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036675 MIMAT0031893 hsa-miR-181b-2-3p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0031893 miRNA Homo sapiens 22058130 Nucleus HeLa cell Next-generation sequencing "Here, we present a data set excluding these RNA before sequencing through locked nucleic acids (LNA), greatly increasing pre-miRNA sequence counts with no discernable effect on pre-miRNA or mature miRNA sequencing. Analysis of profiles generated in total, nuclear and cytoplasmic cell fractions reveals that pre-miRNAs are subject to a wide range of regulatory processes involving loci-specific 3'- and 5'-end variation entailing complex cleavage patterns with co-occurring polyuridylation. Data were collected from Supplementary file. " RLID00036676 MIMAT0032029 hsa-miR-1249-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0032029 miRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "Because the abundance of most miRNAs is low in the exosomes, we defined detectable miRNAs as those that had at least one sequence per million mappable miRNA reads. Accordingly, we detected a total of 593 known miRNAs in the 14 libraries. In each individual library, the number of detectable known miRNAs varied from 380 to 474 with an average of 419 [see Additional file 2]. Data are collected from Additional file 2: Read counts of the miRNAs detected in the 14 libraries (normalized to read number per million mappable miRNA seqeuences). " RLID00036677 MIMAT0032029 hsa-miR-1249-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0032029 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036678 MIMAT0032116 hsa-miR-4485-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0032116 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036679 MIMAT0032116 hsa-miR-4485-5p http://www.mirbase.org/cgi-bin/mature.pl?mature_acc=MIMAT0032116 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing The differential association of miRNA to mitochondria of both HEK293 and HeLa has been summarized in Table S3. Data are collected from Table S3: Pattern of miRNAs associated with mitochondria of HEK293 and HeLa. RLID00036680 RLGI00001 hsa-novel_mir_36 miRNA Homo sapiens 24577456 Circulating Serum Next-generation sequencing The detected serum miRNAs then were validated by qRT-PCR in 158 patients and 155 controls. Table 2 has displayed the data. RLID00036681 RLGI00002 hsa-pmiR-chr1-2130 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00036682 RLGI00003 hsa-pmiR-chr19-5802 miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00036683 RLGI00004 hsa-pmiR-U2-snRNA miRNA Homo sapiens 25359176 Circulating Serum Next-generation sequencing "In this study, we focused on examining global circulating miRNA profiles in serum samples from subjects with liver injury caused by accidental acetaminophen (APAP) overdose. Upon applying next generation high-throughput sequencing of small RNA libraries, we identified 36 miRNAs, including 3 novel miRNA-like small nuclear RNAs, which were enriched in the serum of APAP overdosed subjects. The location of the best hit for the sequences is shown in Supplementary Table 2. Data are collected from Table S2. " RLID00036684 RLGI00005 gma-miR4422a miRNA Glycine max 21504877 Nucleus Leaf In situ hybridization "Furthermore, localization studies showed that a novel soybean miRNA, miR4422a, was nuclear-localized. " RLID00036685 RLGI00006 hcrsv-miR-H1-5p miRNA Hibiscus cannabinus 23155403 Nucleus Seedling RT-PCR|Northern blot "The vir-miRNA (hcrsv-miR-H1-5p) was detected using TaqMan stem-loop real-time PCR, and by northern blot using DIG-end labeled probe in HCRSV-infected kenaf leaves. Finally, a novel nuclear localization signal (NLS) was discovered in p23 of HCRSV. " RLID00036686 RLGI00007 hcrsv-miR-H1-5p miRNA Hibiscus chlorotic ringspot virus 23155403 Nucleus Seedling RT-PCR|Northern blot "The vir-miRNA (hcrsv-miR-H1-5p) was detected using TaqMan stem-loop real-time PCR, and by northern blot using DIG-end labeled probe in HCRSV-infected kenaf leaves. Finally, a novel nuclear localization signal (NLS) was discovered in p23 of HCRSV. " RLID00036687 RLGI00008 293m8-m0001 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036688 RLGI00009 293m8-m0002 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036689 RLGI00010 293m8-m0003 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036690 RLGI00011 293m8-m0004 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036691 RLGI00012 293m8-m0005 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036692 RLGI00013 293m8-m0006 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036693 RLGI00014 293m8-m0007 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036694 RLGI00015 293m8-m0008 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036695 RLGI00016 293m8-m0009 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036696 RLGI00017 293m8-m0010 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036697 RLGI00018 293m8-m0011 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036698 RLGI00019 293m8-m0012 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036699 RLGI00020 293m8-m0013 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036700 RLGI00021 293m8-m0014 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036701 RLGI00022 293m8-m0015 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036702 RLGI00023 293m8-m0016 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036703 RLGI00024 293m8-m0017 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036704 RLGI00025 293m8-m0018 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036705 RLGI00026 293m8-m0019 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036706 RLGI00027 293m8-m0020 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036707 RLGI00028 293m8-m0021 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036708 RLGI00029 293m8-m0022 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036709 RLGI00030 293m8-m0023 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036710 RLGI00031 293m8-m0024 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036711 RLGI00032 293m8-m0025 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036712 RLGI00033 293m8-m0026 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036713 RLGI00034 293m8-m0027 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036714 RLGI00035 293m8-m0028 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036715 RLGI00036 293m8-m0029 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036716 RLGI00037 293m8-m0030 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036717 RLGI00038 293m8-m0031 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036718 RLGI00039 293m8-m0032 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036719 RLGI00040 293m8-m0033 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036720 RLGI00041 293m8-m0034 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036721 RLGI00042 293m8-m0035 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036722 RLGI00043 293m8-m0036 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036723 RLGI00044 293m8-m0037 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036724 RLGI00045 293m8-m0038 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036725 RLGI00046 293m8-m0039 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036726 RLGI00047 293m8-m0040 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036727 RLGI00048 293m8-m0041 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036728 RLGI00049 293m8-m0042 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036729 RLGI00050 293m8-m0043 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036730 RLGI00051 293m8-m0044 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036731 RLGI00052 293m8-m0045 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036732 RLGI00053 293m8-m0046 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036733 RLGI00054 293m8-m0047 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036734 RLGI00055 293m8-m0048 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036735 RLGI00056 293m8-m0049 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036736 RLGI00057 293m8-m0050 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036737 RLGI00058 293m8-m0051 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036738 RLGI00059 293m8-m0052 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036739 RLGI00060 293m8-m0053 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036740 RLGI00061 293m8-m0054 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036741 RLGI00062 293m8-m0055 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036742 RLGI00063 293m8-m0056 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036743 RLGI00064 293m8-m0057 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036744 RLGI00065 293m8-m0058 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036745 RLGI00066 293m8-m0059 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036746 RLGI00067 293m8-m0060 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036747 RLGI00068 293m8-m0061 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036748 RLGI00069 293m8-m0062 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036749 RLGI00070 293m8-m0063 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036750 RLGI00071 293m8-m0064 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036751 RLGI00072 293m8-m0065 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036752 RLGI00073 293m8-m0066 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036753 RLGI00074 293m8-m0067 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036754 RLGI00075 293m8-m0068 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036755 RLGI00076 293m8-m0069 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036756 RLGI00077 293m8-m0070 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036757 RLGI00078 293m8-m0071 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036758 RLGI00079 293m8-m0072 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036759 RLGI00080 293m8-m0073 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036760 RLGI00081 293m8-m0074 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036761 RLGI00082 293m8-m0075 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036762 RLGI00083 293m8-m0076 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036763 RLGI00084 293m8-m0077 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036764 RLGI00085 293m8-m0078 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036765 RLGI00086 293m8-m0079 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036766 RLGI00087 293m8-m0080 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036767 RLGI00088 293m8-m0081 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036768 RLGI00089 293m8-m0082 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036769 RLGI00090 293m8-m0083 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036770 RLGI00091 293m8-m0084 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036771 RLGI00092 293m8-m0085 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036772 RLGI00093 293m8-m0086 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036773 RLGI00094 293m8-m0087 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036774 RLGI00095 293m8-m0088 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036775 RLGI00096 293m8-m0089 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036776 RLGI00097 293m8-m0090 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036777 RLGI00098 293m8-m0091 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036778 RLGI00099 293m8-m0092 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036779 RLGI00100 293m8-m0093 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036780 RLGI00101 293m8-m0094 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036781 RLGI00102 293m8-m0095 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036782 RLGI00103 293m8-m0096 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036783 RLGI00104 293m8-m0097 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036784 RLGI00105 293m8-m0098 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036785 RLGI00106 293m8-m0099 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036786 RLGI00107 293m8-m0100 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036787 RLGI00108 293m8-m0101 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036788 RLGI00109 293m8-m0102 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036789 RLGI00110 293m8-m0103 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036790 RLGI00111 293m8-m0104 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036791 RLGI00112 293m8-m0105 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036792 RLGI00113 293m8-m0106 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036793 RLGI00114 293m8-m0107 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036794 RLGI00115 293m8-m0108 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036795 RLGI00116 293m8-m0109 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036796 RLGI00117 293m8-m0110 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036797 RLGI00118 293m8-m0111 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036798 RLGI00119 293m8-m0112 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036799 RLGI00120 293m8-m0113 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036800 RLGI00121 293m8-m0114 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036801 RLGI00122 293m8-m0115 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036802 RLGI00123 293m8-m0116 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036803 RLGI00124 293m8-m0117 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036804 RLGI00125 293m8-m0118 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036805 RLGI00126 293m8-m0119 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036806 RLGI00127 293m8-m0120 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036807 RLGI00128 293m8-m0121 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036808 RLGI00129 293m8-m0122 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036809 RLGI00130 293m8-m0123 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036810 RLGI00131 293m8-m0124 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036811 RLGI00132 293m8-m0125 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036812 RLGI00133 293m8-m0126 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036813 RLGI00134 293m8-m0127 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036814 RLGI00135 293m8-m0128 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036815 RLGI00136 293m8-m0129 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036816 RLGI00137 293m8-m0130 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036817 RLGI00138 293m8-m0131 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036818 RLGI00139 293m8-m0132 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036819 RLGI00140 293m8-m0133 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036820 RLGI00141 293m8-m0134 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036821 RLGI00142 293m8-m0135 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036822 RLGI00143 293m8-m0136 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036823 RLGI00144 293m8-m0137 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036824 RLGI00145 293m8-m0138 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036825 RLGI00146 293m8-m0139 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036826 RLGI00147 293m8-m0140 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036827 RLGI00148 293m8-m0141 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036828 RLGI00149 293m8-m0142 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036829 RLGI00150 293m8-m0143 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036830 RLGI00151 293m8-m0144 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036831 RLGI00152 293m8-m0145 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036832 RLGI00153 293m8-m0146 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036833 RLGI00154 293m8-m0147 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036834 RLGI00155 293m8-m0148 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036835 RLGI00156 293m8-m0149 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036836 RLGI00157 293m8-m0150 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036837 RLGI00158 293m8-m0151 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036838 RLGI00159 293m8-m0152 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036839 RLGI00160 293m8-m0153 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036840 RLGI00161 293m8-m0154 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036841 RLGI00162 293m8-m0155 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036842 RLGI00163 293m8-m0156 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036843 RLGI00164 293m8-m0157 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036844 RLGI00165 293m8-m0158 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036845 RLGI00166 293m8-m0159 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036846 RLGI00167 293m8-m0160 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036847 RLGI00168 293m8-m0161 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036848 RLGI00169 293m8-m0162 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036849 RLGI00170 293m8-m0163 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036850 RLGI00171 293m8-m0164 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036851 RLGI00172 293m8-m0165 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036852 RLGI00173 293m8-m0166 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036853 RLGI00174 293m8-m0167 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036854 RLGI00175 293m8-m0168 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036855 RLGI00176 293m8-m0169 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036856 RLGI00177 293m8-m0170 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036857 RLGI00178 293m8-m0171 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036858 RLGI00179 293m8-m0172 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036859 RLGI00180 293m8-m0173 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036860 RLGI00181 293m8-m0174 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036861 RLGI00182 293m8-m0175 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036862 RLGI00183 293m8-m0176 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036863 RLGI00184 293m8-m0177 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036864 RLGI00185 293m8-m0178 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036865 RLGI00186 293m8-m0179 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036866 RLGI00187 293m8-m0180 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036867 RLGI00188 293m8-m0181 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036868 RLGI00189 293m8-m0182 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036869 RLGI00190 293m8-m0183 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036870 RLGI00191 293m8-m0184 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036871 RLGI00192 293m8-m0185 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036872 RLGI00193 293m8-m0186 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036873 RLGI00194 293m8-m0187 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036874 RLGI00195 293m8-m0188 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036875 RLGI00196 293m8-m0189 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036876 RLGI00197 293m8-m0190 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036877 RLGI00198 293m8-m0191 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036878 RLGI00199 293m8-m0192 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036879 RLGI00200 293m8-m0193 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036880 RLGI00201 293m8-m0194 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036881 RLGI00202 293m8-m0195 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036882 RLGI00203 293m8-m0196 miRNA Homo sapiens 22984580 Mitochondrion Eembryonic kidney cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036883 RLGI00204 HM3-m0001 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036884 RLGI00205 HM3-m0002 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036885 RLGI00206 HM3-m0003 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036886 RLGI00207 HM3-m0004 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036887 RLGI00208 HM3-m0005 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036888 RLGI00209 HM3-m0006 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036889 RLGI00210 HM3-m0007 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036890 RLGI00211 HM3-m0008 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036891 RLGI00212 HM3-m0009 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036892 RLGI00213 HM3-m0010 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036893 RLGI00214 HM3-m0011 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036894 RLGI00215 HM3-m0012 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036895 RLGI00216 HM3-m0013 miRNA Homo sapiens 22984580 Mitochondrion HeLa cell Next-generation sequencing "Reads were subsequently mapped to identify 4 395 094 and 3 676 525 reads that matched sequences in the mouse genome and miRBase in uninfected and prion-infected exosomes, respectively (Supplementary Table S4). Data are collected from Table S4: Putative novel miRNAs associated with mitochondria of HEK293 and HeLa. " RLID00036896 RLGI00217 hsa-miRPlus-A1031 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00036897 RLGI00218 hsa-miRPlus-C1087 miRNA Homo sapiens 24460325 Exosome K562 cell Microarray "Cluster analysis arranged samples and miRNAs into groups based on their expression levels, which allowed us to hypothesize the relationships between miRNAs and samples. Interestingly, 49 miRNAs were up regulated in exosomes as compared to K562 cells (Table 1), with both P-value of <= 0.05 and more than 1.5-fold changes. Data are collected from Table 1. Differentially Expressed miRNAs Between Exosomes and K562 Cells. " RLID00036898 RLGI00219 hsa-miRPlus-C1089 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00036899 RLGI00220 hsa-miRPlus-D1033 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00036900 RLGI00221 hsa-miRPlus-D1046 miRNA Homo sapiens 21637849 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR "Table 4: List of microRNA significantly detected in the mitochondrial mRNA at three increasing mtRNA inputs (1, 5 and 35 uL). Table S3 List of microRNA significantly detected (Cp<35) in the mitochondrial mRNA at the two highest mtRNA inputs (5 and 35 uL). Data are collected from Table 4 and S3. " RLID00036901 RLGI00222 novel-miR-01 miRNA Mus musculus 23761296 Circulating Serum Next-generation sequencing "In this way, we identified 39 putative novel miRNAs in the two libraries: 22 novel miRNAs in the lung tumor library and 17 in the normal adjacent lung tissue library. Nine novel miRNAs were shared by both libraries (Supplementary table S2). Data are collected from Table S2. " RLID00036902 RLGI00223 novel-miR-02 miRNA Mus musculus 23761296 Circulating Serum Next-generation sequencing "In this way, we identified 39 putative novel miRNAs in the two libraries: 22 novel miRNAs in the lung tumor library and 17 in the normal adjacent lung tissue library. Nine novel miRNAs were shared by both libraries (Supplementary table S2). Data are collected from Table S2. " RLID00036903 RLGI00224 novel-miR-03 miRNA Mus musculus 23761296 Circulating Serum Next-generation sequencing "In this way, we identified 39 putative novel miRNAs in the two libraries: 22 novel miRNAs in the lung tumor library and 17 in the normal adjacent lung tissue library. Nine novel miRNAs were shared by both libraries (Supplementary table S2). Data are collected from Table S2. " RLID00036904 RLGI00225 novel-miR-04 miRNA Mus musculus 23761296 Circulating Serum Next-generation sequencing "In this way, we identified 39 putative novel miRNAs in the two libraries: 22 novel miRNAs in the lung tumor library and 17 in the normal adjacent lung tissue library. Nine novel miRNAs were shared by both libraries (Supplementary table S2). Data are collected from Table S2. " RLID00036905 RLGI00226 novel-miR-05 miRNA Mus musculus 23761296 Circulating Serum Next-generation sequencing "In this way, we identified 39 putative novel miRNAs in the two libraries: 22 novel miRNAs in the lung tumor library and 17 in the normal adjacent lung tissue library. Nine novel miRNAs were shared by both libraries (Supplementary table S2). Data are collected from Table S2. " RLID00036906 RLGI00227 novel-miR-06 miRNA Mus musculus 23761296 Circulating Serum Next-generation sequencing "In this way, we identified 39 putative novel miRNAs in the two libraries: 22 novel miRNAs in the lung tumor library and 17 in the normal adjacent lung tissue library. Nine novel miRNAs were shared by both libraries (Supplementary table S2). Data are collected from Table S2. " RLID00036907 RLGI00228 novel-miR-07 miRNA Mus musculus 23761296 Circulating Serum Next-generation sequencing "In this way, we identified 39 putative novel miRNAs in the two libraries: 22 novel miRNAs in the lung tumor library and 17 in the normal adjacent lung tissue library. Nine novel miRNAs were shared by both libraries (Supplementary table S2). Data are collected from Table S2. " RLID00036908 RLGI00229 novel-miR-08 miRNA Mus musculus 23761296 Circulating Serum Next-generation sequencing "In this way, we identified 39 putative novel miRNAs in the two libraries: 22 novel miRNAs in the lung tumor library and 17 in the normal adjacent lung tissue library. Nine novel miRNAs were shared by both libraries (Supplementary table S2). Data are collected from Table S2. " RLID00036909 RLGI00230 novel-miR-09 miRNA Mus musculus 23761296 Circulating Serum Next-generation sequencing "In this way, we identified 39 putative novel miRNAs in the two libraries: 22 novel miRNAs in the lung tumor library and 17 in the normal adjacent lung tissue library. Nine novel miRNAs were shared by both libraries (Supplementary table S2). Data are collected from Table S2. " RLID00036910 RLGI00231 csR-16sr-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data are shown in supplementary material. RLID00036911 RLGI00232 csR-16sr-10 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036912 RLGI00233 csR-16sr-2 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036913 RLGI00234 csR-16sr-3 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036914 RLGI00235 csR-16sr-4 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036915 RLGI00236 csR-16sr-5 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036916 RLGI00237 csR-16sr-6 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036917 RLGI00238 csR-23sr-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036918 RLGI00239 csR-23sr-2 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036919 RLGI00240 csR-23sr-3 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036920 RLGI00241 csR-4.5sr-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036921 RLGI00242 csR-5sr-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036922 RLGI00243 csR-5sr-2 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036923 RLGI00244 csR-5sr-3 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036924 RLGI00245 csR-ig-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036925 RLGI00246 csR-ig-2 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036926 RLGI00247 csR-ig-3 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036927 RLGI00248 csR-ig-4 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036928 RLGI00249 csR-ig-5 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036929 RLGI00250 csR-ig-6 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036930 RLGI00251 csR-ig-7 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036931 RLGI00252 csR-mNDH-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036932 RLGI00253 csR-mPSB-3 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036933 RLGI00254 csR-mPSB-4 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036934 RLGI00255 csR-mPSB-5 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036935 RLGI00256 csR-mRPL-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036936 RLGI00257 csR-mYCF-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036937 RLGI00258 csR-mYCF-2 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036938 RLGI00259 csR-trnA-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036939 RLGI00260 csR-trnC-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036940 RLGI00261 csR-trnD-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036941 RLGI00262 csR-trnE-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036942 RLGI00263 csR-trnF-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036943 RLGI00264 csR-trnF-2 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036944 RLGI00265 csR-trnG-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036945 RLGI00266 csR-trnG-2 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036946 RLGI00267 csR-trnH-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036947 RLGI00268 csR-trnL-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036948 RLGI00269 csR-trnL-2 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036949 RLGI00270 csR-trnL-3 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036950 RLGI00271 csR-trnM-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036951 RLGI00272 csR-trnN-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036952 RLGI00273 csR-trnN-2 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036953 RLGI00274 csR-trnP-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036954 RLGI00275 csR-trnQ-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036955 RLGI00276 csR-trnS-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036956 RLGI00277 csR-trnT-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036957 RLGI00278 csR-trnV-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Microarray A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036958 RLGI00279 novel csRNA-1 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036959 RLGI00280 novel csRNA-2 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036960 RLGI00281 novel csRNA-3 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036961 RLGI00282 novel csRNA-4 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036962 RLGI00283 novel csRNA-5 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036963 RLGI00284 novel csRNA-6 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036964 RLGI00285 novel csRNA-7 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036965 RLGI00286 novel csRNA-8 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036966 RLGI00287 novel csRNA-9 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036967 RLGI00288 novel csRNA-10 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036968 RLGI00289 novel csRNA-11 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036969 RLGI00290 novel csRNA-12 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036970 RLGI00291 novel csRNA-13 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036971 RLGI00292 novel csRNA-14 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036972 RLGI00293 novel csRNA-15 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036973 RLGI00294 novel csRNA-16 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036974 RLGI00295 novel csRNA-17 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036975 RLGI00296 novel csRNA-18 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036976 RLGI00297 novel csRNA-19 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036977 RLGI00298 novel csRNA-20 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036978 RLGI00299 novel csRNA-21 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036979 RLGI00300 novel csRNA-22 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036980 RLGI00301 novel csRNA-23 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036981 RLGI00302 novel csRNA-24 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036982 RLGI00303 novel csRNA-25 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036983 RLGI00304 novel csRNA-26 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036984 RLGI00305 novel csRNA-27 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036985 RLGI00306 novel csRNA-28 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036986 RLGI00307 novel csRNA-29 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036987 RLGI00308 novel csRNA-30 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036988 RLGI00309 novel csRNA-31 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036989 RLGI00310 novel csRNA-32 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036990 RLGI00311 novel csRNA-33 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036991 RLGI00312 novel csRNA-34 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036992 RLGI00313 novel csRNA-35 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036993 RLGI00314 novel csRNA-36 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036994 RLGI00315 novel csRNA-37 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036995 RLGI00316 novel csRNA-38 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036996 RLGI00317 novel csRNA-39 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036997 RLGI00318 novel csRNA-40 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036998 RLGI00319 novel csRNA-41 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00036999 RLGI00320 novel csRNA-42 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00037000 RLGI00321 novel csRNA-43 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00037001 RLGI00322 novel csRNA-44 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00037002 RLGI00323 novel csRNA-45 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00037003 RLGI00324 novel csRNA-46 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00037004 RLGI00325 novel csRNA-47 csRNA Brassica rapa subsp. Pekinensis 21639890 Chloroplast Seedling Next-generation sequencing A novel class of heat-responsive small RNAs derived from the chloroplast genome of Chinese cabbage (Brassica rapa). Data is shown in supplementary material. RLID00037005 RLGI00326 ASAR6 Asynchronous replication and Autosomal RNA on chromosome 6 lncRNA Homo sapiens 23593023 Nucleus Skin fibroblast In situ hybridization|RT-PCR "ASAR6 RNA is synthesized by RNA Polymerase II, is not polyadenlyated, is restricted to the nucleus, and is subject to random mono-allelic expression. " RLID00037006 RLGI00327 1/2-sbsRNA1 lncRNA Homo sapiens 21307942 Cytoplasm HeLa cell qRT-PCR "RT-semiquantitative (sq)PCR (Supplementary Fig. 2a) demonstrated that 1/2-sbsRNA1 is detected in cytoplasmic but not nuclear HeLa-cell fractions and is polyadenylated (Supplementary Fig. 2b,c). " RLID00037007 RLGI00328 alncRNA-EC1 lncRNA Mus musculus 24200680 Nucleus Liver erythroid cell qRT-PCR We focus on 12 such candidates and find that they are nuclear-localized and exhibit complex developmental expression patterns. Data are collected from Figure 6. RLID00037008 RLGI00329 alncRNA-EC2 lncRNA Mus musculus 24200680 Nucleus Liver erythroid cell qRT-PCR We focus on 12 such candidates and find that they are nuclear-localized and exhibit complex developmental expression patterns. Data are collected from Figure 6. RLID00037009 RLGI00330 alncRNA-EC3 lncRNA Mus musculus 24200680 Nucleus Liver erythroid cell qRT-PCR We focus on 12 such candidates and find that they are nuclear-localized and exhibit complex developmental expression patterns. Data are collected from Figure 6. RLID00037010 RLGI00331 alncRNA-EC7 lncRNA Mus musculus 24200680 Nucleus Liver erythroid cell qRT-PCR We focus on 12 such candidates and find that they are nuclear-localized and exhibit complex developmental expression patterns. Data are collected from Figure 6. RLID00037011 RLGI00332 ASncmtRNAs-1 lncRNA Homo sapiens 21347712 Nucleus Kidney In situ hybridizationq|Electron microscopy "In normal human kidney and mouse testis the SncmtRNA and the ASncmtRNAs were found outside the organelle and especially localized in the nucleus associated to heterochromatin. In cancer cells, only the SncmtRNA was expressed and was found associated to heterochromatin and nucleoli. " RLID00037012 RLGI00332 ASncmtRNAs-1 lncRNA Mus musculus 21347712 Nucleus Testis In situ hybridizationq|Electron microscopy "In normal human kidney and mouse testis the SncmtRNA and the ASncmtRNAs were found outside the organelle and especially localized in the nucleus associated to heterochromatin. In cancer cells, only the SncmtRNA was expressed and was found associated to heterochromatin and nucleoli. " RLID00037013 RLGI00333 ASncmtRNAs-2 lncRNA Homo sapiens 21347712 Nucleus Kidney In situ hybridizationq|Electron microscopy "In normal human kidney and mouse testis the SncmtRNA and the ASncmtRNAs were found outside the organelle and especially localized in the nucleus associated to heterochromatin. In cancer cells, only the SncmtRNA was expressed and was found associated to heterochromatin and nucleoli. " RLID00037014 RLGI00333 ASncmtRNAs-2 lncRNA Mus musculus 21347712 Nucleus Testis In situ hybridizationq|Electron microscopy "In normal human kidney and mouse testis the SncmtRNA and the ASncmtRNAs were found outside the organelle and especially localized in the nucleus associated to heterochromatin. In cancer cells, only the SncmtRNA was expressed and was found associated to heterochromatin and nucleoli. " RLID00037015 RLGI00334 Bsr lncRNA Rattus norvegicus 17507654 Cytoplasm Fibroblast In situ hybridization "On drug treatments, a fraction of Bsr RNA relocalizes to the cytoplasm and associates with stress granules (SGs), but not with P-bodies, pointing to a potential link between SGs and the metabolism of ncRNA. Thus, Bsr might represent a novel type of nuclear-retained transcript. " RLID00037016 RLGI00334 Bsr lncRNA Rattus norvegicus 10095072 Nucleus Brain In situ hybridization None of the ORFs found in cDNA sequences is likely to be significant;Bsr RNA appears not to be polyadenylated at its 3'end;Bsr RNA was localized in the nucleus. RLID00037017 RLGI00335 elncRNA-EC1 lncRNA Mus musculus 24200680 Nucleus Liver erythroid cell qRT-PCR We focus on 12 such candidates and find that they are nuclear-localized and exhibit complex developmental expression patterns. Data are collected from Figure 6. RLID00037018 RLGI00335 elncRNA-EC3 lncRNA Mus musculus 24200680 Nucleus Liver erythroid cell qRT-PCR We focus on 12 such candidates and find that they are nuclear-localized and exhibit complex developmental expression patterns. Data are collected from Figure 6. RLID00037019 RLGI00336 lincMKLN-1 lncRNA Homo sapiens 19571010 Nucleus HFF|HLF|HeLa cell Fluorescence in situ hybridization "Figure 3b: Subcellular localization analysis of lincRNAs by RNA FISH demonstrates localization of lincRNAs to the nucleus. Each panel represents the in situ hybridization of �0 fluorescently labeled DNA oligos with complementarity to the interrogated lincRNA. RNA FISH experiments were performed in male hFF for each represented lincRNA (XIST, HOTAIR, TUG-1, lincMKLN-1, lincFOXF1, and lincSFPQ), and also in female hLF for XIST (XX). White “speckles�indicate the subcellular localization of each lincRNA. The nuclear compartment is demarked by DAPI staining (purple). " RLID00037020 RLGI00337 lincSFPQ lncRNA Homo sapiens 19571010 Nucleus HFF|HLF|HeLa cell Fluorescence in situ hybridization "Figure 3b: Subcellular localization analysis of lincRNAs by RNA FISH demonstrates localization of lincRNAs to the nucleus. Each panel represents the in situ hybridization of �0 fluorescently labeled DNA oligos with complementarity to the interrogated lincRNA. RNA FISH experiments were performed in male hFF for each represented lincRNA (XIST, HOTAIR, TUG-1, lincMKLN-1, lincFOXF1, and lincSFPQ), and also in female hLF for XIST (XX). White “speckles�indicate the subcellular localization of each lincRNA. The nuclear compartment is demarked by DAPI staining (purple). " RLID00037021 RLGI00337 lincSFPQ lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00037022 RLGI00337 lincSFPQ lncRNA Homo sapiens 25630241 Nucleus Hela cell qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00037023 RLGI00337 lincSFPQ lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00037024 RLGI00338 Delta-zein mRNA Oryza sativa 19508424 Endoplasmic reticulum Endosperm RT-PCR "When the 10-kDa Delta-zein RNAs were mis-localized to the cisternal ER (Figure 2d), zein polypeptides were evident only in the PSVs (Figures 2e,f and 4b). These results indicate that the final site of deposition of 10-kDa Delta-zein within the endomembrane system is dependent on its RNA location to distinct cortical ER subdomains. " RLID00037025 RLGI00338 Delta-zein mRNA Oryza sativa 19605415 Endoplasmic reticulum Endosperm RT-PCR "Fig. 1 shows the schematic representation of the 10 kDa δ-zein transgenes containing various segments of the glutelin transcript sequences as well as their spatial distribution to the PB-ER and cisternal ER as viewed by in situ RT-PCR using the 10 kDa δ-zein-specific primers. In the absence of glutelin sequences, the 10 kDa δ-zein RNA is targeted to the PB-ER in transgenic rice endosperm cells (Hamada et al. 2003b). The presence of intact glutelin transcript sequences as part of the 3�UTR resulted in re-directing RNA targeting to the cisternal ER. " RLID00037026 RLGI00339 ZNF2 lncRNA Saccharomyces cerevisiae 26588844 Nucleus Yeast Fluorescence in situ hybridization "Nonetheless, as expected for an mRNA, we observed ZNF2 transcripts in both the nucleus and the cytosol (Fig 7E and 7F). Interestingly, we observed a higher percentile of ZNF2 transcripts localized in the nuclei in the rze1Δ mutant (44.7% cytoplasmic: 55.2% nuclear distribution compared to that in the wild type (69.6% cytoplasmic: 30.4% nuclear distribution) (Fig 7G and S2 and S3 Tables). " RLID00037027 RLGI00339 ZNF2 mRNA Saccharomyces cerevisiae 26588844 Cytoplasm Yeast Fluorescence in situ hybridization "Nonetheless, as expected for an mRNA, we observed ZNF2 transcripts in both the nucleus and the cytosol (Fig 7E and 7F). Interestingly, we observed a higher percentile of ZNF2 transcripts localized in the nuclei in the rze1Δ mutant (44.7% cytoplasmic: 55.2% nuclear distribution compared to that in the wild type (69.6% cytoplasmic: 30.4% nuclear distribution) (Fig 7G and S2 and S3 Tables). " RLID00037028 RLGI00340 ZNF160 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037029 RLGI00341 ZF-1 mRNA Ascidian 17570671 Posterior Embryo Immunostaining "We observed localization of ZF-1 mRNA, which is a type I postplasmic/PEM mRNA, as an indicator for PVC . In control MO-injected embryos, ZF-1 mRNA was localized close to the posterior pole at the four- and eight-cell stages in all cases (n = 12 and 19 for the four- and eight- cell embryos, respectively; Figures 4 A-4B 0 , white arrows), whereas in embryos injected with Hr-PEM MO, ZF-1 mRNA was located more vegetally (92% and 100% of 13 and 14 cases at the four- and eight-cell stages, respectively; Figures 4 C-4D 0 ). " RLID00037030 RLGI00341 ZF-1 mRNA Ascidian 17570671 Vegetal Embryo Immunostaining "We observed localization of ZF-1 mRNA, which is a type I postplasmic/PEM mRNA, as an indicator for PVC . In control MO-injected embryos, ZF-1 mRNA was localized close to the posterior pole at the four- and eight-cell stages in all cases (n = 12 and 19 for the four- and eight- cell embryos, respectively; Figures 4 A-4B 0 , white arrows), whereas in embryos injected with Hr-PEM MO, ZF-1 mRNA was located more vegetally (92% and 100% of 13 and 14 cases at the four- and eight-cell stages, respectively; Figures 4 C-4D 0 ). " RLID00037031 RLGI00342 zein mRNA Oryza sativa 19508424 Endoplasmic reticulum Endosperm RT-PCR "These hybrid GFP-zein RNAs (Figure 1, constructs 3 and 4) were distributed not only to the PB-ER but also to the cisternal ER. " RLID00037032 RLGI00343 Xlsirt lncRNA Xenopus laevis 7505061 Mitochondrion Oocyte - Xlsirts are a family of interspersed repeat RNAs from Xenopus laevis that contain from 3 to 13 repeat units (each 79 to 81 nucleotides long) flanked by unique sequences. They are homologous to the mammalian Xist gene that is involved in X chromosome inactivation. Xlsirt RNA appears first in the mitochondrial cloud (Balbiani body) in stage 2 oocytes and is then translocated as island-like structures to the vegetal cortex at early stage 3 coincident with the localization of the germ plasm. Exogenous Xlsirt RNA injected into oocytes translocates to the location of the endogenous RNA at that particular stage. RLID00037033 RLGI00343 Xlsirt lncRNA Xenopus laevis 7505061 Vegetal Oocyte - Xlsirts are a family of interspersed repeat RNAs from Xenopus laevis that contain from 3 to 13 repeat units (each 79 to 81 nucleotides long) flanked by unique sequences. They are homologous to the mammalian Xist gene that is involved in X chromosome inactivation. Xlsirt RNA appears first in the mitochondrial cloud (Balbiani body) in stage 2 oocytes and is then translocated as island-like structures to the vegetal cortex at early stage 3 coincident with the localization of the germ plasm. Exogenous Xlsirt RNA injected into oocytes translocates to the location of the endogenous RNA at that particular stage. RLID00037034 RLGI00343 Xlsirt lncRNA Xenopus laevis 7539356 Mitochondrion Oocyte In situ hybridization "One of these, through which Xlsirts, Xcat2 and Xwnt11 are localized, involves transport during stages 1 and 2 of oogenesis via a region of the mitochondrial cloud that we call the message transport organizer or METRO. This pathway involved three steps, transport of RNA from the GV to the mitochondrial cloud, sorting of the RNAs to specific regions of the METRO, and translocation to and anchoring at the vegetal cortex. " RLID00037035 RLGI00343 Xlsirt lncRNA Xenopus laevis 8948579 Cytoplasm Oocyte In situ hybridization During translocation through the cytoplasm Xlsirt and Xcat2 RNAs were detected associated with cytoplasmic particles of different morphologies. RLID00037036 RLGI00343 Xlsirt lncRNA Xenopus laevis 8948579 Mitochondrion Oocyte In situ hybridization "In the present study we analyzed the properties of the METRO pathway, which localizes Xlsirt, Xcat2, and Xwnt11 RNAs to a specific region of the vegetal cortex during stage 1 of oogenesis. A combination of methodologies involving both fixed material and living oocytes was used to analyze RNA localization. We show that in early diplotene pre-stage 1 oocytes (25-50 microm in diameter) both endogenous and injected exogenous METRO RNAs translocated to multiple mitochondrial aggregates (pre-mitochondrial clouds) that surround the germinal vesicle (GV). However, by early stage 1 (diplotene oocytes, 50-200 microm), all three of the RNAs discriminated between the different clouds and translocated exclusively within the METRO of a single mitochondrial cloud. " RLID00037037 RLGI00343 Xlsirt lncRNA Xenopus laevis 8948579 Vegetal Oocyte In situ hybridization "In the present study we analyzed the properties of the METRO pathway, which localizes Xlsirt, Xcat2, and Xwnt11 RNAs to a specific region of the vegetal cortex during stage 1 of oogenesis. A combination of methodologies involving both fixed material and living oocytes was used to analyze RNA localization. We show that in early diplotene pre-stage 1 oocytes (25-50 microm in diameter) both endogenous and injected exogenous METRO RNAs translocated to multiple mitochondrial aggregates (pre-mitochondrial clouds) that surround the germinal vesicle (GV). However, by early stage 1 (diplotene oocytes, 50-200 microm), all three of the RNAs discriminated between the different clouds and translocated exclusively within the METRO of a single mitochondrial cloud. " RLID00037038 RLGI00343 Xlsirt lncRNA Xenopus laevis 9545550 Mitochondrion Oocyte In situ hybridization "To help distinguish between these alternatives, we made several constructs in which we linked the Xlsirts localization signals to various regions of the full-length Vg1 mRNA (Fig. 1) and tested the ability of the chimeric RNAs to move to the mitochondrial cloud in stage 1 oocytes. Fig. 2. Localization of endogenous and exogenous Xlsirts and Vg1 RNAs in oocytes. (A) Whole-mount in situ hybridization with Xlsirt RNA probe in late stage 1 oocytes. The arrow points to the endogenous Xlsirt RNA localized in the METRO region of the mitochondrial cloud. (C) Whole mount in situ hybridization with Vg1 RNA probe in late stage 1 oocytes, Vg1 RNA is dispersed in the oocyte cytoplasm and is excluded from the mitochondrial cloud (arrow). (D) Injected Vg1 RNA spreads throughout the cytoplasm and is excluded from the mitochondrial cloud in late stage 1 oocytes (arrow). (E) Stage 1 oocytes injected with Vg-Xlsirt chimeric RNA showing localization in the METRO region of the mitochondrial cloud (arrows). " RLID00037039 RLGI00343 Xlsirt lncRNA Xenopus laevis 9545550 Endoplasmic reticulum Oocyte In situ hybridization Stage 3 oocyte showing endogenous Xlsirts (in situ hybridization) localized at the vegetal cortex (blue) at the leading edge of the wedge-shaped ER (red) (the arrow is pointing to the Xlsirts at the leading edge of the ER). Note that by stage 2 the ER is also uniformly distributed throughout the entire cortical region. Late stage 3 oocyte showing Xlsirts localized within the cortex (blue) and the remnants of the wedge containing ER (red). RLID00037040 RLGI00343 Xlsirt lncRNA Xenopus laevis 9545550 Vegetal Oocyte In situ hybridization "To definitively demonstrate the co-localization of Vg1 mRNA with the wedge-shaped ER structure we performed in situ hybridization to identify the location of the Vg1 mRNA, and immunostaining with GRP-78 to identify the position of the ER. During stage 1, while Vg1 mRNA was dispersed throughout the cytoplasm, very little ER was associated with the cortex. (D) Stage 3 oocyte showing endogenous Xlsirts (in situ hybridization) localized at the vegetal cortex (blue) at the leading edge of the wedge-shaped ER (red) (the arrow is pointing to the Xlsirts at the leading edge of the ER). Note that by stage 2 the ER is also uniformly distributed throughout the entire cortical region. (E) Late stage 3 oocyte showing Xlsirts localized within the cortex (blue) and the remnants of the wedge containing ER (red). " RLID00037041 RLGI00343 Xlsirt lncRNA Xenopus laevis 9739112 Vegetal Oocyte In situ hybridization "We focused on Xlsirts, Xcat2, and Xwnt11 transcripts that are localized to the vegetal cortex through a region of the mitochondrial cloud called the messenger transport organizer (METRO) that also contains the nuage or germ plasm. At the ultrastructural level Xcat2 mRNA was detected on germinal granules while Xlsirts and Xwnt11 were associated with a fibrillar network of the germ plasm in stage-1 and stage-4 oocytes. " RLID00037042 RLGI00343 Xlsirt lncRNA Xenopus laevis 9739112 Mitochondrion Oocyte In situ hybridization "We focused on Xlsirts, Xcat2, and Xwnt11 transcripts that are localized to the vegetal cortex through a region of the mitochondrial cloud called the messenger transport organizer (METRO) that also contains the nuage or germ plasm. At the ultrastructural level Xcat2 mRNA was detected on germinal granules while Xlsirts and Xwnt11 were associated with a fibrillar network of the germ plasm in stage-1 and stage-4 oocytes. " RLID00037043 RLGI00343 Xlsirt lncRNA Xenopus laevis 9739112 Germ plasm Oocyte In situ hybridization "We focused on Xlsirts, Xcat2, and Xwnt11 transcripts that are localized to the vegetal cortex through a region of the mitochondrial cloud called the messenger transport organizer (METRO) that also contains the nuage or germ plasm. At the ultrastructural level Xcat2 mRNA was detected on germinal granules while Xlsirts and Xwnt11 were associated with a fibrillar network of the germ plasm in stage-1 and stage-4 oocytes. " RLID00037044 RLGI00343 Xlsirt lncRNA Xenopus laevis 11784096 Germ plasm Oocyte In situ hybridization "The germ plasm is a specialized region of oocyte cytoplasm that contains determinants of germ cell fate. In Xenopus oocytes, the germ plasm is a part of the METRO region of mitochondrial cloud. It contains the germinal granules and a variety of coding and noncoding RNAs that include Xcat2, Xlsirts, Xdazl, DEADSouth, Xpat, Xwnt11, fatVg, B7/Fingers, C10/XFACS, and mitochondrial large and small rRNA. We analyzed the distribution of these 11 different RNAs within the various compartments of germ plasm during Xenopus oogenesis and development by using whole-mount electron microscopy in situ hybridization. " RLID00037045 RLGI00343 Xlsirt lncRNA Xenopus laevis 11784096 Mitochondrion Oocyte In situ hybridization "The germ plasm is a specialized region of oocyte cytoplasm that contains determinants of germ cell fate. In Xenopus oocytes, the germ plasm is a part of the METRO region of mitochondrial cloud. It contains the germinal granules and a variety of coding and noncoding RNAs that include Xcat2, Xlsirts, Xdazl, DEADSouth, Xpat, Xwnt11, fatVg, B7/Fingers, C10/XFACS, and mitochondrial large and small rRNA. We analyzed the distribution of these 11 different RNAs within the various compartments of germ plasm during Xenopus oogenesis and development by using whole-mount electron microscopy in situ hybridization. " RLID00037046 RLGI00343 Xlsirt lncRNA Xenopus laevis 12676327 Vegetal Oocyte In situ hybridization It is likely that the Xlsirt RNA at the cortex was heterogeneous population and that the individual Xlsirt RNAs were too rare to detect by this methodology. RLID00037047 RLGI00343 Xlsirt lncRNA Xenopus laevis 19223445 Mitochondrion Oocyte Quantitative RNA localization assay "Early RNAs, such as Xcat-2, Xlsirt, and Xwnt, become localized to a large subcellular structure called the Balbiani body or mitochondrial cloud. " RLID00037048 RLGI00344 XLOC_012599 lncRNA Homo sapiens 25630241 Cytoplasm Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037049 RLGI00345 XLOC_011950 lncRNA Homo sapiens 25630241 Cytoplasm Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037050 RLGI00345 XLOC_011950 lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037051 RLGI00346 XLOC_011226 lncRNA Homo sapiens 25630241 Cytoplasm Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037052 RLGI00346 XLOC_011226 lncRNA Homo sapiens 25630241 Nucleus Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037053 RLGI00347 XLOC_011185 lncRNA Homo sapiens 25630241 Cytoplasm Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037054 RLGI00347 XLOC_011185 lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00037055 RLGI00347 XLOC_011185 lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037056 RLGI00348 XLOC_010514 lncRNA Homo sapiens 25630241 Cytoplasm Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037057 RLGI00348 XLOC_010514 lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037058 RLGI00349 XLOC_010017 lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00037059 RLGI00349 XLOC_010017 lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037060 RLGI00349 XLOC_010017 lncRNA Homo sapiens 25630241 Nucleus Hela cell qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00037061 RLGI00350 XLOC_009233 lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00037062 RLGI00351 XLOC_006922 lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00037063 RLGI00351 XLOC_006922 lncRNA Homo sapiens 25630241 Nucleus Hela cell qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00037064 RLGI00351 XLOC_006922 lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00037065 RLGI00352 XLOC_005764 lncRNA Homo sapiens 25630241 Nucleus Foreskin fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00037066 RLGI00352 XLOC_005764 lncRNA Homo sapiens 25630241 Nucleus Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037067 RLGI00353 XLOC_004803 lncRNA Homo sapiens 25630241 Cytoplasm Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037068 RLGI00353 XLOC_004803 lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037069 RLGI00354 XLOC_003526 lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00037070 RLGI00354 XLOC_003526 lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037071 RLGI00355 XLOC_002746 lncRNA Homo sapiens 25630241 Cytoplasm Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037072 RLGI00355 XLOC_002746 lncRNA Homo sapiens 25630241 Nucleus Hela cell qRT-PCR|Fluorescence in situ hybridization "Figure 3: Most lincRNAs are predominantly localized to the nucleus. (a) Boxplots describing the distribution of the fraction of molecules localized to the nucleus (Y axis) for each validated lncRNA-cell pair (X axis, orange: HeLa, blue: hFF, purple: hLF). Red bar: medians. Whiskers are at 1.5* the inner quartile range. Data are collected from Figure 3. " RLID00037073 RLGI00355 XLOC_002746 lncRNA Homo sapiens 25630241 Nucleus Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037074 RLGI00355 XLOC_002746 lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037075 RLGI00356 XLOC_002094 lncRNA Homo sapiens 25630241 Cytoplasm Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037076 RLGI00356 XLOC_002094 lncRNA Homo sapiens 25630241 Nucleus Lung fibroblast Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037077 RLGI00357 vGluT3 mRNA Columba livia 25116931 Nucleus Neuron|Retina In situ hybridization In situ hybridization revealed that the vGluT3 mRNA was expressed in neurons of the caudal linear nucleus (LC) of the brain and in amacrine cells of the inner nuclear layer of the retina. Double staining showed that the signals for the vGluT3 mRNA and serotonin colocalized in cells of the inner nuclear layer (Fig. 4E). RLID00037078 RLGI00358 Val-TAC tRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037079 RLGI00359 Val-GTG tRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "In cellular RNA, we observed fragments located at the 5�or 3′end of the mature tRNA (Table 3). However, the most abundant tRNA hits in shuttle RNA were all located at the 5′end of mature tRNAs. Data are collected from Table 3: Most abundant tRNA fragments in cellular and shuttle RNA. " RLID00037080 RLGI00360 Val-GTA tRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "In cellular RNA, we observed fragments located at the 5�or 3′end of the mature tRNA (Table 3). However, the most abundant tRNA hits in shuttle RNA were all located at the 5′end of mature tRNAs. Data are collected from Table 3: Most abundant tRNA fragments in cellular and shuttle RNA. " RLID00037081 RLGI00361 Val-CAC tRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037082 RLGI00362 UsnRNAs lncRNA Homo sapiens 22855529 Nucleus Hela cell In situ hybridization "Nuclear speckle-associated RNAs include uridine-rich small nuclear RNAs (UsnRNAs), 7SK RNA, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) long ncRNA (lncRNA), and a population of uncharacterized poly(A)+ RNAs (Spector and Lamond, 2011 blue right-pointing triangle). " RLID00037083 RLGI00363 UQCRB mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037084 RLGI00364 Ul snRNA Mus musculus 2967782 Nucleus Oocyte|Embryo In situ hybridization "In general Ul RNA transcripts appeared to be in both nuclear and cytoplasmic compartments, but when grain counts were carried out on larger photographs of blastocyst sections, the grain density was higher over the nuclei than over the cytoplasm. " RLID00037085 RLGI00364 Ul snRNA Mus musculus 2967782 Cytoplasm Oocyte|Embryo In situ hybridization "In general Ul RNA transcripts appeared to be in both nuclear and cytoplasmic compartments, but when grain counts were carried out on larger photographs of blastocyst sec- tions, the grain density was higher over the nuclei than over the cytoplasm. " RLID00037086 RLGI00365 UBE2V1 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037087 RLGI00366 U6 snRNA Rattus norvegicus 25792744 Nucleus Myocardium qRT-PCR "For both cytosolic isolation methods, immunoblotting showed enrichment of cytosolic proteins and depletion of nuclear/nucleolar proteins in cytosolic fractions, whereas qPCR demonstrated that the small ncRNAs 7SK and U6 were predominantly in the nuclear fraction (Fig. 1, E-H). " RLID00037088 RLGI00367 U6 snRNA Cricetulus griseus 16644724 Nucleus Ovary cell RT-PCR|Northern blot "FIGURE 5. XBP1 mRNA splicing occurs in the cytoplasm. CHO/mXBP1ΔC(un)-d2EGFP reporter cells were treated with Tm for 4 h and then RNAs were isolated from total (T), nuclear (N), and cytoplasmic (C) fractions and used for RT-PCR analysis (A). To demonstrate the quality of the fractionation, nucleoplasmic (N) and cytoplasmic (C) RNAs were monitored by Northern blot analysis for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (B), tRNALys (C), and U6 small nuclear RNA (D). All RNAs shown were isolated from the same experiment. GADPH is shown as a loading control (E). The image of RNA stained with ethidium bromide in a formaldehyde/agarose gel demonstrates the quality of the RNA. N.B. indicates Northern blot. " RLID00037089 RLGI00368 U6 snRNA Mus musculus 18410515 Synapse ForeBrain qRT-PCR "We noted that levels of all RNAs measured, including ribosomal 18S RNA, U6, CAMK2a and BC1, as well as mature microRNAs and their precursors, were lower in synaptosomes relative to that observed in synaptoneurosomes. " RLID00037090 RLGI00369 U5 snRNA Pisum sativum 2030967 Nucleus Pea epicotyl tissue Next-generation sequencing "To identify the snRNA structural variants stably expressed in pea nuclei, we have constructed a cDNA library enriched in pea snRNAs. Initial screening of the cDNA library has led to the isolation of numerous Ul, U2, U4 and U5 snRNA clones. Sequence analysis of the clones has allowed us to demonstrate that four of the five snRNAs required for splicing are represented by sequence variants expressed in pea nuclei. " RLID00037091 RLGI00370 U49 snoRNA Zea mays 9664033 Nucleolus Seed In situ hybridization "Fig. 2. Confocal images of maize root sections labelled with an antibody to fibrillarin (green) and by fluorescence in situ hybridization to each of the four novel snoRNAs (red). In each case the right hand panel shows the superimposition of the two labels. (A) U49 (box C/D) shows a similar pattern to fibrillarin, although the nucleolar cavity region is often labelled by the snoRNA probe (arrow). The coiled bodies are clearly labelled by anti-fibrillarin, but very weakly labelled by the snoRNA probe (arrowhead). (B) snoR1 (box C/D) shows a complementary labelling pattern to fibrillarin, and the nucleolar cavity is usually strongly labelled (arrow in red panel). The coiled bodies are not labelled by the snoRNA probe (arrowhead in green panel). (C) snoR2 (box H/ACA) labels a very similar region to fibrillarin, but the coiled bodies are not labelled (arrowhead in green panel). The nucleolar cavity is unlabelled by the snoRNA probe. (D) snoR3 (box C/D) shows a very similar labelling pattern to fibrillarin, but, again, the coiled bodies are unlabelled (arrowhead in green panel). Bar, 10um. Data are collected from Figure 2. " RLID00037092 RLGI00371 U4 snRNA Pisum sativum 2030967 Nucleus Pea epicotyl tissue Next-generation sequencing "To identify the snRNA structural variants stably expressed in pea nuclei, we have constructed a cDNA library enriched in pea snRNAs. Initial screening of the cDNA library has led to the isolation of numerous Ul, U2, U4 and U5 snRNA clones. Sequence analysis of the clones has allowed us to demonstrate that four of the five snRNAs required for splicing are represented by sequence variants expressed in pea nuclei. " RLID00037093 RLGI00372 U3 snoRNA Solanum tuberosum 7816606 Nucleolus Leaf|Ovule|Silk In situ hybridization Control in situ hybridisations were carried out using oligonucleotides complementary to plant Ul snRNA and U3 snoRNA sequences and showed specific labelling to the nucleoplasm and nucleoli respectively RLID00037094 RLGI00373 U3 snoRNA Zea mays 7816606 Nucleolus Leaf|Ovule|Silk In situ hybridization Control in situ hybridisations were carried out using oligonucleotides complementary to plant Ul snRNA and U3 snoRNA sequences and showed specific labelling to the nucleoplasm and nucleoli respectively RLID00037095 RLGI00374 U3 snoRNA Olea europaea 9352223 Nucleus Microsporocytes In situ hybridization "The presence of U3 snoRNA, as shown by in situ hybridization in nuclear bodies from plant material, is also evidence that these structures are coiled bodies. " RLID00037096 RLGI00375 U2 snRNA Pisum sativum 2030967 Nucleus Pea epicotyl tissue Next-generation sequencing "To identify the snRNA structural variants stably expressed in pea nuclei, we have constructed a cDNA library enriched in pea snRNAs. Initial screening of the cDNA library has led to the isolation of numerous Ul, U2, U4 and U5 snRNA clones. Sequence analysis of the clones has allowed us to demonstrate that four of the five snRNAs required for splicing are represented by sequence variants expressed in pea nuclei. " RLID00037097 RLGI00376 U2 snRNA Human herpesvirus 4 1332043 Nucleus Raji cell In situ hybridization "In contrast, use of the same technique indicated an exclusively nuclear location for cellular U2 RNA. " RLID00037098 RLGI00377 U2 snRNA Bos taurus 1571156 Nucleus Oocyte In situ hybridization "The U2 antisense distribution was confined almost exclusively to the nuclei, since in embryo sections where a nucleus was not included in the plane of section (Fig. 2A; four-cell em- bryo, with only three nuclei in the plane of section), only a small number of silver grains in that region of the section were observed. " RLID00037099 RLGI00378 U2 snRNA Allium cepa 22526497 Nucleus Meristematic cell Fluorescence in situ hybridization "U2 snRNA was detected by in situ hybridisation. Although the overall signal intensity was weak, we were able to detect U2 snRNA which was localised at the chromatin periphery and in the condensed chromatin (Supplemental data Fig. S2b, c). " RLID00037100 RLGI00378 U2 snRNA Allium cepa 22526497 Nucleus Meristematic cell Fluorescence in situ hybridization Fig.1f Localisation U2 snRNA. The bright spots are Cajal bodies (arrows). Diffuse staining of the nucleoplasm is also observed. Data are collected from Figure 1F. RLID00037101 RLGI00379 U1 snoRNA Solanum tuberosum 7816606 Nucleoplasm Leaf|Ovule|Silk In situ hybridization Control in situ hybridisations were carried out using oligonucleotides complementary to plant Ul snRNA and U3 snoRNA sequences and showed specific labelling to the nucleoplasm and nucleoli respectively RLID00037102 RLGI00380 U1 snoRNA Zea mays 7816606 Nucleoplasm Leaf|Ovule|Silk In situ hybridization Control in situ hybridisations were carried out using oligonucleotides complementary to plant Ul snRNA and U3 snoRNA sequences and showed specific labelling to the nucleoplasm and nucleoli respectively RLID00037103 RLGI00381 U1 snRNA Pisum sativum 2030967 Nucleus Pea epicotyl tissue Next-generation sequencing "To identify the snRNA structural variants stably expressed in pea nuclei, we have constructed a cDNA library enriched in pea snRNAs. Initial screening of the cDNA library has led to the isolation of numerous Ul, U2, U4 and U5 snRNA clones. Sequence analysis of the clones has allowed us to demonstrate that four of the five snRNAs required for splicing are represented by sequence variants expressed in pea nuclei. " RLID00037104 RLGI00382 tyrosine hydroxylase mRNA Rattus norvegicus 7753814 Axon Hypothalamus In situ hybridization There is evidence to suggest that tyrosine hydroxylase mRNA is stored in the axons of magnocellular neurons in the internal zone of the median eminence and that this is transferred back into the perikaryon following the application of an acute osmotic stimulus. RLID00037105 RLGI00383 Ty1 mRNA Saccharomyces cerevisiae 24603646 Endoplasmic reticulum Yeast Northern blot "The association of Ty1 RNA with SRP-RNC complexes and the presence of Gag in the ER lumen suggest that Gag is co-translationally translocated to the ER lumen. SRP directs nascent polypeptides to the ER lumen by binding to the SRP receptor and delivering the nascent peptides to the ER translocon, (Figure 1). Together, the results demonstrate that retrosomes are dynamic foci formed by the coalescence of Ty1 RNA translation complexes at the ER. " RLID00037106 RLGI00383 Ty1 mRNA Saccharomyces cerevisiae 24603646 Cytoplasm Yeast Northern blot "Since Gag also associates with SRP-RNC complexes in the cytoplasm (Figure 4B), the most plausible scenario to explain these findings is that Gag, once it folds into a stable conformation in the ER lumen, is retrotranslocated to the cytoplasm, where it associates with Ty1 RNA on SRP-RNC complexes. " RLID00037107 RLGI00384 tubulin mRNA Gallus gallus 2738094 Lamellipodium Skeletal Myoblast|Fibroblast Immunocytochemistry|In situ hybridization "Conversely only 35 % of tubulin or vimentin messages were found in lamellipodia. Two cells, analyzed for hybridization to tubulin and vimentin mRNAs showed a perinuclear localization (65% of the messages), consistent with previous work cited above. " RLID00037108 RLGI00384 tubulin mRNA Gallus gallus 3698103 Cytoplasm Embryo blasts|Fibroblast In situ hybridization "Actin mRNA concentrations were highest at cell extremities, generally in lamellipodia, where grain densities were up to 16-fold higher than in areas near the nucleus. Vimentin mRNA, unlike actin mRNA, was distributed near the nucleus. Tubulin mRNA appeared most concentrated in the peripheral cytoplasm. These results demonstrate that cytoplasmic mRNAs are localized in specific, nonrandom cellular patterns and that localized concentrations of specific proteins may result from corresponding localization of their respective mRNAs. Hence, actin mRNA distribution may result in increased concentration of actin filaments in lamellipodia of motile cells. " RLID00037109 RLGI00385 TUBBA4 mRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00037110 RLGI00386 TRNY.3 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647887 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229472 RLID00037111 RLGI00387 TRNY.2 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647864 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229432 RLID00037112 RLGI00388 TRNY.1 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647912 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229427 RLID00037113 RLGI00389 TRNY https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647967 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229558 RLID00037114 RLGI00390 TRNW https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648076 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229594 RLID00037115 RLGI00390 TRNW https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647959 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229486 RLID00037116 RLGI00391 TRNV.3 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648057 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229384 RLID00037117 RLGI00392 TRNV.2 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647979 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229624 RLID00037118 RLGI00393 TRNV.1 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648036 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229578 RLID00037119 RLGI00394 TRNT.2 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647972 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229573 RLID00037120 RLGI00395 TRNT.1 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648017 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229560 RLID00037121 RLGI00396 TRNS.5 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647847 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229509 RLID00037122 RLGI00397 TRNS.4 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647917 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229471 RLID00037123 RLGI00398 TRNS.3 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648083 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229571 RLID00037124 RLGI00398 TRNS.3 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647954 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229435 RLID00037125 RLGI00400 TRNS.2 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648010 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229563 RLID00037126 RLGI00400 TRNS.2 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647856 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229426 RLID00037127 RLGI00402 TRNS.1 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648033 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229543 RLID00037128 RLGI00403 TRNR.3 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647971 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229648 RLID00037129 RLGI00404 TRNR.2 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647988 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229631 RLID00037130 RLGI00405 TRNR.1 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648032 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229545 RLID00037131 RLGI00406 TRNQ https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648030 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229540 RLID00037132 RLGI00406 TRNQ https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647922 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229488 RLID00037133 RLGI00408 TRNP https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647834 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229428 RLID00037134 RLGI00409 TRNN.2 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648012 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229647 RLID00037135 RLGI00410 TRNN.1 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647977 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229632 RLID00037136 RLGI00411 TRNN https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647945 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229431 RLID00037137 RLGI00412 TRNM.2 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647822 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229527 RLID00037138 RLGI00413 TRNM https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647994 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229579 RLID00037139 RLGI00414 TRNL.4 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648074 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229388 RLID00037140 RLGI00415 TRNL.3 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648002 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229636 RLID00037141 RLGI00416 TRNL.2 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648035 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229621 RLID00037142 RLGI00417 TRNL.1 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648013 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229574 RLID00037143 RLGI00418 TRNK.2 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647849 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229463 RLID00037144 RLGI00419 TRNK https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648066 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229537 RLID00037145 RLGI00420 TRNI.4 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648001 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229391 RLID00037146 RLGI00421 TRNI.3 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647976 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229382 RLID00037147 RLGI00422 TRNI.2 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648062 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229626 RLID00037148 RLGI00423 TRNI.1 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648088 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229618 RLID00037149 RLGI00424 TRNI https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647931 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229439 RLID00037150 RLGI00425 TRNH https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647964 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229535 RLID00037151 RLGI00426 TRNG.2 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648059 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229565 RLID00037152 RLGI00427 TRNG.1 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648058 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229544 RLID00037153 RLGI00428 TRNFM https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648005 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229566 RLID00037154 RLGI00429 TRNE https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648019 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229559 RLID00037155 RLGI00429 TRNE https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647892 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229473 RLID00037156 RLGI00431 TRND https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648009 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229557 RLID00037157 RLGI00431 TRND https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647861 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229500 RLID00037158 RLGI00431 TRND https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647861 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229500 RLID00037159 RLGI00434 TRNC https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648023 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229554 RLID00037160 RLGI00434 TRNC https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000647878 tRNA Arabidopsis thaliana 22140109 Mitochondrion - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229429 RLID00037161 RLGI00436 tRNAVal-TAC tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037162 RLGI00436 tRNAVal-TAC tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037163 RLGI00438 tRNAVal-CAC tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037164 RLGI00438 tRNAVal-CAC tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037165 RLGI00440 tRNAVal-AAC tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037166 RLGI00440 tRNAVal-AAC tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037167 RLGI00442 tRNATyr-GTA tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037168 RLGI00442 tRNATyr-GTA tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037169 RLGI00444 tRNATrp-CCA tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037170 RLGI00444 tRNATrp-CCA tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037171 RLGI00446 tRNAThr-TGT tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037172 RLGI00446 tRNAThr-TGT tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037173 RLGI00448 tRNAThr-CGT tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037174 RLGI00448 tRNAThr-CGT tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037175 RLGI00450 tRNAThr-AGT tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037176 RLGI00450 tRNAThr-AGT tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037177 RLGI00452 tRNASer-TGA tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037178 RLGI00452 tRNASer-TGA tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037179 RLGI00454 tRNASer-GCT tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037180 RLGI00454 tRNASer-GCT tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037181 RLGI00456 tRNASer-CGA tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037182 RLGI00456 tRNASer-CGA tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037183 RLGI00458 tRNASer-AGA tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037184 RLGI00458 tRNASer-AGA tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037185 RLGI00460 tRNAPro-TGG tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037186 RLGI00460 tRNAPro-TGG tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037187 RLGI00462 tRNAPro-CGG tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037188 RLGI00462 tRNAPro-CGG tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037189 RLGI00464 tRNAPro-AGG tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037190 RLGI00464 tRNAPro-AGG tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037191 RLGI00466 tRNAPhe-GAA tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037192 RLGI00466 tRNAPhe-GAA tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037193 RLGI00468 tRNAMet-CAT tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037194 RLGI00468 tRNAMet-CAT tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037195 RLGI00470 tRNALys-TTT tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037196 RLGI00470 tRNALys-TTT tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037197 RLGI00472 tRNALys-CTT tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037198 RLGI00472 tRNALys-CTT tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037199 RLGI00474 tRNALeu-TAG tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037200 RLGI00474 tRNALeu-TAG tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037201 RLGI00476 tRNALeu-TAA tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037202 RLGI00476 tRNALeu-TAA tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037203 RLGI00478 tRNALeu-CAG tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037204 RLGI00478 tRNALeu-CAG tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037205 RLGI00480 tRNALeu-CAA tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037206 RLGI00480 tRNALeu-CAA tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037207 RLGI00482 tRNALeu-AAG tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037208 RLGI00482 tRNALeu-AAG tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037209 RLGI00484 tRNAIle-TAT tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037210 RLGI00485 tRNAIle-AAT tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037211 RLGI00485 tRNAIle-AAT tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037212 RLGI00487 tRNAHis-GTG tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037213 RLGI00487 tRNAHis-GTG tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037214 RLGI00489 tRNAGly-TCC tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037215 RLGI00489 tRNAGly-TCC tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037216 RLGI00491 tRNAGly-GCC tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037217 RLGI00491 tRNAGly-GCC tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037218 RLGI00493 tRNAGly-CCC tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037219 RLGI00493 tRNAGly-CCC tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037220 RLGI00495 tRNAGlu-TTC tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037221 RLGI00495 tRNAGlu-TTC tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037222 RLGI00497 tRNAGlu-CTC tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037223 RLGI00497 tRNAGlu-CTC tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037224 RLGI00499 tRNA-GlnUUG tRNA Homo sapiens 21854988 Mitochondrion - qRT-PCR "We found several nuclear-encoded tRNA species to be enriched within mitoplasts relative to mitochondrial preparations, including the previously detected tRNA-GlnUUG, an enrichment that was confirmed by qRT-PCR (Figure 3F,G). " RLID00037225 RLGI00500 tRNAGln-TTG tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037226 RLGI00500 tRNAGln-TTG tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037227 RLGI00502 tRNAGln-CTG tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037228 RLGI00502 tRNAGln-CTG tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037229 RLGI00504 tRNA-derived_pseudogene tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037230 RLGI00504 tRNA-derived_pseudogene tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037231 RLGI00506 tRNACys-GCA tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037232 RLGI00506 tRNACys-GCA tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037233 RLGI00508 tRNAAsp-GTC tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037234 RLGI00508 tRNAAsp-GTC tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037235 RLGI00510 tRNAAsn-GTT tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037236 RLGI00510 tRNAAsn-GTT tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037237 RLGI00512 tRNAAsn-ATT tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037238 RLGI00512 tRNAAsn-ATT snoRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037239 RLGI00514 tRNAArg-TCT tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037240 RLGI00514 tRNAArg-TCT tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037241 RLGI00516 tRNAArg-TCG tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037242 RLGI00516 tRNAArg-TCG tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037243 RLGI00518 tRNAArg-CCT tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037244 RLGI00518 tRNAArg-CCT tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037245 RLGI00520 tRNAArg-CCG tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037246 RLGI00520 tRNAArg-CCG tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037247 RLGI00522 tRNAArg-ACG tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037248 RLGI00522 tRNAArg-ACG tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037249 RLGI00524 tRNAAla-TGC tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037250 RLGI00524 tRNAAla-TGC tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037251 RLGI00526 tRNAAla-CGC tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037252 RLGI00526 tRNAAla-CGC tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037253 RLGI00528 tRNAAla-AGC tRNA Homo sapiens 20498841 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037254 RLGI00528 tRNAAla-AGC tRNA Homo sapiens 20498841 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing "Table S1: The N/C values of diverse sRNAs. sRNAs with raw read counts (non-normalized) more than 10 in at least one library were listed. N/C indicates the ratio of nuclear sRNA library count to cytoplasmic sRNA library count of each unique sequence. Nuclear and cytoplasmic indicate the read counts in the nuclear and cytoplasmic sRNA libraries, respectively. Read count of each sRNA were normalized to reads per million (RPM). Data are collected from Table S1. " RLID00037255 RLGI00530 TRNA.2 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648024 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229381 RLID00037256 RLGI00531 TRNA.1 https://www.arabidopsis.org/servlets/TairObject?type=gene&id=1000648047 tRNA Arabidopsis thaliana 22140109 Chloroplast - TAIR Data are collected from TAIR database: https://www.arabidopsis.org/servlets/TairObject?type=locus&id=500229627 RLID00037257 RLGI00532 Tm-5 mRNA Rattus norvegicus 8581312 Axon Embryoneuron In situ hybridization Tm-5 mRNA is localized to the axonal pole of differentiating embryonic rat neurons. RLID00037258 RLGI00533 TIGD1 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037259 RLGI00534 TDRD3 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037260 RLGI00535 SYS mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037261 RLGI00536 SYP mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037262 RLGI00537 SYE mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037263 RLGI00538 SUCLA2 mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037264 RLGI00539 subunit A mRNA Manduca sexta 8786331 Ribosome Epithelium In situ hybridization "In situ hybridization showed an even distribution of proteolipid mRNA throughout the cytosol in both cell types of the midgut (Fig. 2A), whereas subunit A mRNA was concentrated in the apical regions (Fig. 1A). Proteolipid mRNA distribution paralleled that of rough endoplasmic reticulum, whereas subunit A mRNA distribution paralleled that of free ribosomes: rough endoplasmic reticulum was abundant around the central nucleus but also extended into the entire cytosol, whereas free ribosomes were highly concentrated at the apical portion of the cell (Fig. 5A-C). In Malpighian tubules, however, subunit A mRNA (Fig. 3A) as well as the proteolipid mRNA (not shown) were evenly distributed. " RLID00037265 RLGI00540 STI3 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037266 RLGI00541 SSUSB mRNA Lemna 12242353 Nucleus Roots|Fronds RNA Gel Blot "While both small subunit genes encoding SSU1 and SSU5B were transcribed at comparable levels in root and frond nuclei, SSU1 mRNA accumulated to high levels in both roots and fronds in contrast to SSU5B mRNA, which was of very low abundance in the roots compared with the fronds. " RLID00037267 RLGI00542 SSU1 mRNA Lemna 12242353 Nucleus Roots|Fronds RNA Gel Blot "While both small subunit genes encoding SSU1 and SSU5B were transcribed at comparable levels in root and frond nuclei, SSU1 mRNA accumulated to high levels in both roots and fronds in contrast to SSU5B mRNA, which was of very low abundance in the roots compared with the fronds. " RLID00037268 RLGI00543 SSA mRNA Oryza sativa 19508424 Endoplasmic reticulum Endosperm RT-PCR In situ RT-PCR using SSA-specific primers revealed that the distribution of SSA RNA was restricted solely to the cisternal ER (Figure 3a). RLID00037269 RLGI00544 SRRP35 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037270 RLGI00545 s-rexs mRNA Rattus norvegicus 8793864 Axon Cerebral cortex neuron Subtractive hybridization "In certain populations of adult brain neurons, most of s-rexs mRNA and a substantial amount of s-rexb mRNA are localized to the axonal pole of the cell body. " RLID00037271 RLGI00546 s-rexb mRNA Rattus norvegicus 8793864 Axon Cerebral cortex Subtractive hybridization "In certain populations of adult brain neurons, most of s-rexs mRNA and a substantial amount of s-rexb mRNA are localized to the axonal pole of the cell body. " RLID00037272 RLGI00547 snoR3 snoRNA Zea mays 9664033 Nucleolus Seed In situ hybridization "Fig. 2. Confocal images of maize root sections labelled with an antibody to fibrillarin (green) and by fluorescence in situ hybridization to each of the four novel snoRNAs (red). In each case the right hand panel shows the superimposition of the two labels. (A) U49 (box C/D) shows a similar pattern to fibrillarin, although the nucleolar cavity region is often labelled by the snoRNA probe (arrow). The coiled bodies are clearly labelled by anti-fibrillarin, but very weakly labelled by the snoRNA probe (arrowhead). (B) snoR1 (box C/D) shows a complementary labelling pattern to fibrillarin, and the nucleolar cavity is usually strongly labelled (arrow in red panel). The coiled bodies are not labelled by the snoRNA probe (arrowhead in green panel). (C) snoR2 (box H/ACA) labels a very similar region to fibrillarin, but the coiled bodies are not labelled (arrowhead in green panel). The nucleolar cavity is unlabelled by the snoRNA probe. (D) snoR3 (box C/D) shows a very similar labelling pattern to fibrillarin, but, again, the coiled bodies are unlabelled (arrowhead in green panel). Bar, 10um. Data are collected from Figure 2. " RLID00037273 RLGI00548 snoR2 snoRNA Zea mays 9664033 Nucleolus Seed In situ hybridization "Fig. 2. Confocal images of maize root sections labelled with an antibody to fibrillarin (green) and by fluorescence in situ hybridization to each of the four novel snoRNAs (red). In each case the right hand panel shows the superimposition of the two labels. (A) U49 (box C/D) shows a similar pattern to fibrillarin, although the nucleolar cavity region is often labelled by the snoRNA probe (arrow). The coiled bodies are clearly labelled by anti-fibrillarin, but very weakly labelled by the snoRNA probe (arrowhead). (B) snoR1 (box C/D) shows a complementary labelling pattern to fibrillarin, and the nucleolar cavity is usually strongly labelled (arrow in red panel). The coiled bodies are not labelled by the snoRNA probe (arrowhead in green panel). (C) snoR2 (box H/ACA) labels a very similar region to fibrillarin, but the coiled bodies are not labelled (arrowhead in green panel). The nucleolar cavity is unlabelled by the snoRNA probe. (D) snoR3 (box C/D) shows a very similar labelling pattern to fibrillarin, but, again, the coiled bodies are unlabelled (arrowhead in green panel). Bar, 10um. Data are collected from Figure 2. " RLID00037274 RLGI00549 snoR1 snoRNA Zea mays 9664033 Nucleolus Seed In situ hybridization "Fig. 2. Confocal images of maize root sections labelled with an antibody to fibrillarin (green) and by fluorescence in situ hybridization to each of the four novel snoRNAs (red). In each case the right hand panel shows the superimposition of the two labels. (A) U49 (box C/D) shows a similar pattern to fibrillarin, although the nucleolar cavity region is often labelled by the snoRNA probe (arrow). The coiled bodies are clearly labelled by anti-fibrillarin, but very weakly labelled by the snoRNA probe (arrowhead). (B) snoR1 (box C/D) shows a complementary labelling pattern to fibrillarin, and the nucleolar cavity is usually strongly labelled (arrow in red panel). The coiled bodies are not labelled by the snoRNA probe (arrowhead in green panel). (C) snoR2 (box H/ACA) labels a very similar region to fibrillarin, but the coiled bodies are not labelled (arrowhead in green panel). The nucleolar cavity is unlabelled by the snoRNA probe. (D) snoR3 (box C/D) shows a very similar labelling pattern to fibrillarin, but, again, the coiled bodies are unlabelled (arrowhead in green panel). Bar, 10um. Data are collected from Figure 2. " RLID00037275 RLGI00550 sno-lncRNA5 lncRNA Homo sapiens 22959273 Nucleus Human cell lines In situ hybridization "Figure 3. Nuclear Localization of snolncRNAs (A) Each PWS region sno-lncRNAexhibits strong nuclear accumulation in PA1 cells. RNA ISH (green) was performed with individual probes recognizing the internal sequence of each snolncRNA, or with pooled probes recognizing all PWS regionsno-lncRNAs (bottom right). Representative images are shown. DAPI is in blue and the white scale bar in all images denotes 10mm. (B) Sno-lncRNAs do not accumulate in either nucleoli or CBs. Costaining of sno-lncRNAs (green) and marker proteins for nucleoli (Nucleolin, red) and CBs (Coilin, red), respectively in H9 cells. Representative images are shown. (C) Sno-lncRNAs accumulate at a single chromosomal locus. Double FISH ofsno-lncRNAs (green) and its adjacent DNA region (red) in both PA1 and H9 cells. A single Z stack of representative images acquired with an Olympus IX70 DeltaVision Deconvolution System microscope is shown. (D) Total RNA from PA1 cells was separated into cytoplasmic (not shown), nuclear soluble, and nuclear insoluble fractions. Bar plots represent relative abundance of RNAs in the nuclear soluble and insoluble fractions as measured by RT-qPCR. Data are collected from Figure 3. " RLID00037276 RLGI00551 sno-lncRNA4 lncRNA Homo sapiens 22959273 Nucleus Human cell lines In situ hybridization "Figure 3. Nuclear Localization of snolncRNAs (A) Each PWS region sno-lncRNAexhibits strong nuclear accumulation in PA1 cells. RNA ISH (green) was performed with individual probes recognizing the internal sequence of each snolncRNA, or with pooled probes recognizing all PWS regionsno-lncRNAs (bottom right). Representative images are shown. DAPI is in blue and the white scale bar in all images denotes 10mm. (B) Sno-lncRNAs do not accumulate in either nucleoli or CBs. Costaining of sno-lncRNAs (green) and marker proteins for nucleoli (Nucleolin, red) and CBs (Coilin, red), respectively in H9 cells. Representative images are shown. (C) Sno-lncRNAs accumulate at a single chromosomal locus. Double FISH ofsno-lncRNAs (green) and its adjacent DNA region (red) in both PA1 and H9 cells. A single Z stack of representative images acquired with an Olympus IX70 DeltaVision Deconvolution System microscope is shown. (D) Total RNA from PA1 cells was separated into cytoplasmic (not shown), nuclear soluble, and nuclear insoluble fractions. Bar plots represent relative abundance of RNAs in the nuclear soluble and insoluble fractions as measured by RT-qPCR. Data are collected from Figure 3. " RLID00037277 RLGI00552 sno-lncRNA3 lncRNA Homo sapiens 22959273 Nucleus Human cell lines In situ hybridization "Figure 3. Nuclear Localization of snolncRNAs (A) Each PWS region sno-lncRNAexhibits strong nuclear accumulation in PA1 cells. RNA ISH (green) was performed with individual probes recognizing the internal sequence of each snolncRNA, or with pooled probes recognizing all PWS regionsno-lncRNAs (bottom right). Representative images are shown. DAPI is in blue and the white scale bar in all images denotes 10mm. (B) Sno-lncRNAs do not accumulate in either nucleoli or CBs. Costaining of sno-lncRNAs (green) and marker proteins for nucleoli (Nucleolin, red) and CBs (Coilin, red), respectively in H9 cells. Representative images are shown. (C) Sno-lncRNAs accumulate at a single chromosomal locus. Double FISH ofsno-lncRNAs (green) and its adjacent DNA region (red) in both PA1 and H9 cells. A single Z stack of representative images acquired with an Olympus IX70 DeltaVision Deconvolution System microscope is shown. (D) Total RNA from PA1 cells was separated into cytoplasmic (not shown), nuclear soluble, and nuclear insoluble fractions. Bar plots represent relative abundance of RNAs in the nuclear soluble and insoluble fractions as measured by RT-qPCR. Data are collected from Figure 3. " RLID00037278 RLGI00553 sno-lncRNA2 lncRNA Homo sapiens 22959273 Nucleus Human cell lines In situ hybridization "Figure 3. Nuclear Localization of snolncRNAs (A) Each PWS region sno-lncRNAexhibits strong nuclear accumulation in PA1 cells. RNA ISH (green) was performed with individual probes recognizing the internal sequence of each snolncRNA, or with pooled probes recognizing all PWS regionsno-lncRNAs (bottom right). Representative images are shown. DAPI is in blue and the white scale bar in all images denotes 10mm. (B) Sno-lncRNAs do not accumulate in either nucleoli or CBs. Costaining of sno-lncRNAs (green) and marker proteins for nucleoli (Nucleolin, red) and CBs (Coilin, red), respectively in H9 cells. Representative images are shown. (C) Sno-lncRNAs accumulate at a single chromosomal locus. Double FISH ofsno-lncRNAs (green) and its adjacent DNA region (red) in both PA1 and H9 cells. A single Z stack of representative images acquired with an Olympus IX70 DeltaVision Deconvolution System microscope is shown. (D) Total RNA from PA1 cells was separated into cytoplasmic (not shown), nuclear soluble, and nuclear insoluble fractions. Bar plots represent relative abundance of RNAs in the nuclear soluble and insoluble fractions as measured by RT-qPCR. Data are collected from Figure 3. " RLID00037279 RLGI00554 sno-lncRNA1 lncRNA Homo sapiens 22959273 Nucleus Human cell lines In situ hybridization "Figure 3. Nuclear Localization of snolncRNAs (A) Each PWS region sno-lncRNAexhibits strong nuclear accumulation in PA1 cells. RNA ISH (green) was performed with individual probes recognizing the internal sequence of each snolncRNA, or with pooled probes recognizing all PWS regionsno-lncRNAs (bottom right). Representative images are shown. DAPI is in blue and the white scale bar in all images denotes 10mm. (B) Sno-lncRNAs do not accumulate in either nucleoli or CBs. Costaining of sno-lncRNAs (green) and marker proteins for nucleoli (Nucleolin, red) and CBs (Coilin, red), respectively in H9 cells. Representative images are shown. (C) Sno-lncRNAs accumulate at a single chromosomal locus. Double FISH ofsno-lncRNAs (green) and its adjacent DNA region (red) in both PA1 and H9 cells. A single Z stack of representative images acquired with an Olympus IX70 DeltaVision Deconvolution System microscope is shown. (D) Total RNA from PA1 cells was separated into cytoplasmic (not shown), nuclear soluble, and nuclear insoluble fractions. Bar plots represent relative abundance of RNAs in the nuclear soluble and insoluble fractions as measured by RT-qPCR. Data are collected from Figure 3. " RLID00037280 RLGI00555 SncmtRNA lncRNA Homo sapiens 21347712 Nucleolus Kidney In situ hybridizationq|Electron microscopy "In normal human kidney and mouse testis the SncmtRNA and the ASncmtRNAs were found outside the organelle and especially localized in the nucleus associated to heterochromatin. In cancer cells, only the SncmtRNA was expressed and was found associated to heterochromatin and nucleoli. " RLID00037281 RLGI00555 SncmtRNA lncRNA Mus musculus 21347712 Nucleolus Testis In situ hybridizationq|Electron microscopy "In normal human kidney and mouse testis the SncmtRNA and the ASncmtRNAs were found outside the organelle and especially localized in the nucleus associated to heterochromatin. In cancer cells, only the SncmtRNA was expressed and was found associated to heterochromatin and nucleoli. " RLID00037282 RLGI00555 SncmtRNA lncRNA Homo sapiens 21347712 Nucleus Kidney In situ hybridizationq|Electron microscopy "In normal human kidney and mouse testis the SncmtRNA and the ASncmtRNAs were found outside the organelle and especially localized in the nucleus associated to heterochromatin. In cancer cells, only the SncmtRNA was expressed and was found associated to heterochromatin and nucleoli. " RLID00037283 RLGI00555 SncmtRNA lncRNA Mus musculus 21347712 Nucleus Testis In situ hybridizationq|Electron microscopy "In normal human kidney and mouse testis the SncmtRNA and the ASncmtRNAs were found outside the organelle and especially localized in the nucleus associated to heterochromatin. In cancer cells, only the SncmtRNA was expressed and was found associated to heterochromatin and nucleoli. " RLID00037284 RLGI00559 shlncRNA-EC6 lncRNA Mus musculus 24200680 Nucleus Liver erythroid cell qRT-PCR We focus on 12 such candidates and find that they are nuclear-localized and exhibit complex developmental expression patterns. Data are collected from Figure 6. RLID00037285 RLGI00561 SCL6 mRNA Arabidopsis thaliana 23622241 Ribosome - RT-PCR "MiRNA target transcripts, such as AGO1, PHB, CSD2, SPL3, SCL6, and TCP4, showed a significant increase in membrane-bound polysomes (MBPs) association in the double mutant, whereas non-target transcripts such as UBQ5, eIF4A, ACTIN8, At2g01570, At5g28770, and At5g66770 were similarly distributed along membrane-bound polysomes (MBPs) fractions in wild type and amp1 lamp1 (Fig 6E). " RLID00037286 RLGI00562 RkB DNA-binding protein mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00037287 RLGI00564 RZE1 lncRNA Saccharomyces cerevisiae 26588844 Nucleus Yeast Fluorescence in situ hybridization We therefore decided to examine the subcellular localization of RZE1 transcripts in the wild-type cells under a mating-inducing condition. We found that RZE1 was predominantly localized in the nucleus (29.3% cytoplasmic: 70.6% nuclear distribution; n = 514) (Fig 7H and S2 Table). RLID00037288 RLGI00564 RZE1 mRNA Saccharomyces cerevisiae 26588844 Cytoplasm Yeast Fluorescence in situ hybridization We therefore decided to examine the subcellular localization of RZE1 transcripts in the wild-type cells under a mating-inducing condition. We found that RZE1 was predominantly localized in the nucleus (29.3% cytoplasmic: 70.6% nuclear distribution; n = 514) (Fig 7H and S2 Table). RLID00037289 RLGI00566 RpVegT mRNA Rana pipiens 15515051 Vegetal Oocyte In situ hybridization "As with RpDazl, RpVegT RNA was localized to a region of the cortex of the clear previtellogenic oocyte (Fig. 4c), although the localization was not as sharply delineated as for RpDazl(Fig. 4a). " RLID00037290 RLGI00567 RPL34 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037291 RLGI00568 RPL12p mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037292 RLGI00569 RPL12m mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037293 RLGI00570 RPL12c mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037294 RLGI00571 RpDazl mRNA Rana pipiens 15515051 Vegetal Oocyte In situ hybridization "To see whether this localization is conserved, the location of RpDazl RNA was examined by in situ hybridization. In full-grown oocytes, RpDazl RNA was localized to the vegetal cortex (Fig. 3a), as in X. laevis. Fig. 3. Whole mount in situ hybridization for RpDazl RNA. " RLID00037295 RLGI00572 RNase P RNA mRNA Saccharomyces cerevisiae 20691904 Mitochondrion Yeast RT-PCR "Figure 4: PNPASE Augments RNase P, 5S rRNA, and MRP RNA Import into Yeast Mitochondria. Data are collected from Figur 4. " RLID00037296 RLGI00573 RH63320-dg mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037297 RLGI00574 RH57802 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037298 RLGI00575 RH55307 mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037299 RLGI00576 RH53041 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037300 RLGI00576 RH53041 mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037301 RLGI00578 RH49548 mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037302 RLGI00578 RH49548 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037303 RLGI00578 RH49548 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037304 RLGI00578 RH49548 mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037305 RLGI00582 RH48308 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037306 RLGI00583 RH47707 mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037307 RLGI00583 RH47707 mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037308 RLGI00585 RH47344 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037309 RLGI00586 RH46030 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037310 RLGI00587 RH43693 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037311 RLGI00587 RH43693 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037312 RLGI00589 RH41467 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037313 RLGI00590 RH39561 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037314 RLGI00591 RH35946 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037315 RLGI00591 RH35946 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037316 RLGI00591 RH35946 mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037317 RLGI00594 RH34608 mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037318 RLGI00595 RH33996-dg mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037319 RLGI00596 RH33270 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037320 RLGI00597 RH28486 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037321 RLGI00598 RH26018 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037322 RLGI00598 RH26018 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037323 RLGI00600 RH25742 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037324 RLGI00600 RH25742 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037325 RLGI00600 RH25742 mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037326 RLGI00603 RH25161 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037327 RLGI00604 RH19967 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037328 RLGI00605 RH19630 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037329 RLGI00606 RH19246 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037330 RLGI00607 RH18418 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037331 RLGI00607 RH18418 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037332 RLGI00609 RH13993 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037333 RLGI00611 RH13061 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037334 RLGI00611 RH13061 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037335 RLGI00611 RH13061 mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037336 RLGI00611 RH13161 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037337 RLGI00614 RH07382 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037338 RLGI00614 RH07382 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037339 RLGI00616 RH06493 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037340 RLGI00617 RH04454 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037341 RLGI00618 RH01124 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037342 RLGI00618 RH01124 mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037343 RLGI00620 RE74714 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037344 RLGI00621 RE72565 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037345 RLGI00622 RE61907 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037346 RLGI00623 RE53686 mRNA Drosophila melanogaster 25838129 Anterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037347 RLGI00623 RE53686 mRNA Drosophila melanogaster 25838129 Posterior Follicle cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037348 RLGI00625 RE36972 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037349 RLGI00625 RE36972 mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037350 RLGI00627 RE36565 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037351 RLGI00628 RE31004 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037352 RLGI00629 RE29470 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037353 RLGI00629 RE29470 mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037354 RLGI00631 RE25729 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037355 RLGI00632 RE18879 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037356 RLGI00633 RE17905 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037357 RLGI00633 RE17905 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037358 RLGI00635 RE17686 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037359 RLGI00636 RE14971 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037360 RLGI00637 RE12750 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037361 RLGI00638 RE11569 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037362 RLGI00638 RE11569 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037363 RLGI00640 RE08153 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037364 RLGI00641 RaxOS lncRNA Mus musculus 15703187 Nucleus Embryonic tissue In situ hybridization|RT-PCR "We detected the expression in adult retina (postnatal day 30, P30) of Six3OS, Six6OS, Otx2OS, CrxOS and RaxOS (Fig. 3 and data not shown). In general, these transcripts were all expressed at higher levels in the inner nuclear layer (INL) and in the ganglion cell layer (GCL). " RLID00037365 RLGI00642 RACK1 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037366 RLGI00643 RAB32 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037367 RLGI00644 psbA mRNA Nicotiana tabacum 8612593 Chloroplast Tobacco Gel mobility shift PsbA mRNA is the most actively translated chloroplast transcript in vivo under light-grown conditions and fusion to lacZ mRNA renders the translation product soluble and eliminates possible effects of the 3'- UTR of psbA mRNA on translation initiation. RLID00037368 RLGI00645 proteolipid mRNA Manduca sexta 8786331 Endoplasmic reticulum Epithelium In situ hybridization "In situ hybridization showed an even distribution of proteolipid mRNA throughout the cytosol in both cell types of the midgut (Fig. 2A), whereas subunit A mRNA was concentrated in the apical regions (Fig. 1A). Proteolipid mRNA distribution paralleled that of rough endoplasmic reticulum, whereas subunit A mRNA distribution paralleled that of free ribosomes: rough endoplasmic reticulum was abundant around the central nucleus but also extended into the entire cytosol, whereas free ribosomes were highly concentrated at the apical portion of the cell (Fig. 5A-C). In Malpighian tubules, however, subunit A mRNA (Fig. 3A) as well as the proteolipid mRNA (not shown) were evenly distributed. " RLID00037369 RLGI00645 proteolipid mRNA Manduca sexta 8786331 Cytosol Epithelium In situ hybridization "In situ hybridization showed an even distribution of proteolipid mRNA throughout the cytosol in both cell types of the midgut (Fig. 2A), whereas subunit A mRNA was concentrated in the apical regions (Fig. 1A). Proteolipid mRNA distribution paralleled that of rough endoplasmic reticulum, whereas subunit A mRNA distribution paralleled that of free ribosomes: rough endoplasmic reticulum was abundant around the central nucleus but also extended into the entire cytosol, whereas free ribosomes were highly concentrated at the apical portion of the cell (Fig. 5A-C). In Malpighian tubules, however, subunit A mRNA (Fig. 3A) as well as the proteolipid mRNA (not shown) were evenly distributed. " RLID00037370 RLGI00647 Prolamine mRNA Oryza sativa 14523246 Endoplasmic reticulum Endosperm RT-PCR "Prolamine and glutelin RNAs are localized to two subdomains of the cortical endoplasmic reticulum (ER), the protein body ER and the cisternal ER, in developing rice seeds. " RLID00037371 RLGI00647 prolamine mRNA Oryza sativa 11048726 Endoplasmic reticulum Endosperm RT-PCR These results indicate that prolamine and glutelin RNAs are distributed on spatially distinct ER subdomains and that prolamine RNAs are localized specifically to the prolamine protein bodies. RLID00037372 RLGI00649 pro alpha 2 collagen mRNA Mus musculus 2405055 Cytoplasm Liver In situ hybridization "In normal mouse liver, pro α2 cob mRNA was detected in a subset of sinusoidal lining cells and was localized to the cytoplasm. " RLID00037373 RLGI00650 PPIAL4Fv2 mRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037374 RLGI00650 PPIAL4Fv2 mRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037375 RLGI00652 PPIAL4Fv1 mRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037376 RLGI00652 PPIAL4Fv1 mRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037377 RLGI00654 PPARbeta mRNA Homo sapiens 10195695 Cytoplasm Skin In situ hybridization Fig. 5. Distribution of PPARbeta mRNA in normal human epidermis. Sections of normal human skin were analyzed by in situ hybridization with a digoxigenin-labeled antisense PPARb probe and an anti-digoxigenenin antibody. The highest level of PPARbeta mRNA expression was found in the upper spinous and granular layers as indicated by the prominent staining of the cytoplasm of cells in the suprabasal layers of the epidermis. RLID00037378 RLGI00655 PPARbeta mRNA Rattus norvegicus 11036239 Cytoplasm Purkinje cell In situ hybridization The in situ hybridization assays showed that PPARbeta transcripts were localized in the cytoplasm of the Purkinje cells. Fig. 4. In situ hybridization detection of PPARb mRNA in cerebellar sections. RLID00037379 RLGI00656 piR-61648 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037380 RLGI00657 piR-60565 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037381 RLGI00658 piR-59293 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037382 RLGI00659 piR-57816 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037383 RLGI00660 piR-57142 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037384 RLGI00661 piR-55361 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037385 RLGI00662 piR-52207 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037386 RLGI00663 piR-48209 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037387 RLGI00664 piR-41405 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037388 RLGI00665 piR-39980 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037389 RLGI00666 piR-39858 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037390 RLGI00667 piR-38581 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037391 RLGI00668 piR-36095 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037392 RLGI00669 piR-35982 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037393 RLGI00670 piR-34896 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037394 RLGI00671 piR-33863 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037395 RLGI00672 piR-32679 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037396 RLGI00673 piR-31068 piRNA Homo sapiens 23302638 Exosome Saliva Next-generation sequencing "Table 5. Ten Most Highly Expressed piRNAs of Exosome I, Exosome II and WS. Data are collected from Table 5. " RLID00037397 RLGI00674 piR-014923 piRNA Homo sapiens 25376581 Exosome Saliva DDPCR "To test the presence of piRNAs in exosomes, 2 highly expressed piRNAs (piR-001184 and piR-014923) were chosen for ddPCR analysis (Fig. 3C). Both piRNAs were identified in at least 2 individuals, which demonstrated predominant localization in exosomal RNA fractions. " RLID00037398 RLGI00675 piR-001184 piRNA Homo sapiens 25376581 Exosome Saliva DDPCR "To test the presence of piRNAs in exosomes, 2 highly expressed piRNAs (piR-001184 and piR-014923) were chosen for ddPCR analysis (Fig. 3C). Both piRNAs were identified in at least 2 individuals, which demonstrated predominant localization in exosomal RNA fractions. " RLID00037399 RLGI00676 PHLP mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037400 RLGI00677 PhCRT mRNA Petunia hybrida 25732863 Cytoplasm Pollen tube Fluorescence in situ hybridization "In elongated tubes of different lengths, PhCRT mRNA was diffusely distributed throughout the cytoplasm of the tube shank, extending from the base to the subapical zone (Fig. 2c, d). " RLID00037401 RLGI00677 PhCRT mRNA Petunia hybrida 25732863 Ribosome Pollen tube Fluorescence in situ hybridization "As germination proceeded, the hybridization and immunolabeling signals were prominent in the cytoplasm of outgrowing pollen tubes (Figs. 2b and 3b). By performing optical sectioning, we observed that PhCRT transcripts accumulated at the base of outgrowing tubes, where they formed rings or collars in the cortical cytoplasm (bracketed region and arrows in Fig. 2b-b' ). In elongated tubes of different lengths, PhCRT mRNA was diffusely distributed throughout the cytoplasm of the tube shank, extending from the base to the subapical zone (Fig. 2c, d). The above results led us to propose that the common sites of PhCRT mRNA, CRT, and 18S rRNA localization in germinating pollen and growing pollen tubes are enriched in ER membrane-bound ribosomes. Together, our results show that the regions in which PhCRT mRNA, CRT protein, and 18S rRNA are localized are also rich in RER. " RLID00037402 RLGI00677 PhCRT mRNA Petunia hybrida 25732863 Endoplasmic reticulum Pollen tube Fluorescence in situ hybridization "As germination proceeded, the hybridization and immunolabeling signals were prominent in the cytoplasm of outgrowing pollen tubes (Figs. 2b and 3b). By performing optical sectioning, we observed that PhCRT transcripts accumulated at the base of outgrowing tubes, where they formed rings or collars in the cortical cytoplasm (bracketed region and arrows in Fig. 2b-b' ). In elongated tubes of different lengths, PhCRT mRNA was diffusely distributed throughout the cytoplasm of the tube shank, extending from the base to the subapical zone (Fig. 2c, d). The above results led us to propose that the common sites of PhCRT mRNA, CRT, and 18S rRNA localization in germinating pollen and growing pollen tubes are enriched in ER membrane-bound ribosomes. Together, our results show that the regions in which PhCRT mRNA, CRT protein, and 18S rRNA are localized are also rich in RER. " RLID00037403 RLGI00680 PH05 mRNA Saccharomyces cerevisiae 8405926 Ribosome Yeast Northern blot "Fig. 1. Segregation of secretory protein mRNA to membrane- bound ribosomes. Northern blot analysis with CYH2, PRC1 and PH05. DNA fragments from the genes CYH2, PRC1 and PH05 hybridized to a Northern blot of 1 ug poly(A)+-RNA from membrane-bound (MBP) and free polysomes (FP). Data are collected from Figure 1. " RLID00037404 RLGI00681 per mRNA Ephestia kuehniella 25637625 Nucleus Eye photoreceptors In situ hybridization "In contrast, a clear daily rhythm in the intensity of nuclear per mRNA expression was found in the eye photoreceptors (Figure 4B). " RLID00037405 RLGI00682 PEM mRNA Ascidian 17570671 Centrosome Embryo Immunostaining "Immunostaining showed that the protein is also present in the posterior cortex and the in centrosome-attracting body (CAB) and that the localization is extraction-resistant. Here we show that PEM of Ascidian is required for correct orientation of early-cleavage planes and subsequent unequal cell divisions because it repeatedly pulls a centrosome toward the posterior cortex and the CAB, respectively, where PEM mRNA and protein are localized. " RLID00037406 RLGI00682 PEM mRNA Ascidian 17570671 Cell cortex Embryo Immunostaining "Then, it is highly concentrated into the CAB during cleavages by the eight-cell stage. PEM mRNA is anchored to cortical ER and relocates together with cortical ER. " RLID00037407 RLGI00682 PEM mRNA Ascidian 17570671 Vegetal Embryo Immunostaining "In the unfertilized egg, it is distributed in a gradient, with the highest concentration at the vegetal pole. Just after fertilization, the first phase of ooplasmic movement brings PEM mRNA to the vegetal pole. " RLID00037408 RLGI00685 PDH-E2 mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037409 RLGI00686 PDH-E1-Alpha mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037410 RLGI00687 pA6 mRNA Doryteuthis pealeii 9272637 Axon Nervous|skeletal muscle In situ hybridization The axonal localization of pA6 mRNA was unequivocally established by in situ hybridization histochemistry. RLID00037411 RLGI00688 oviduct mRNA Ovis aries 8579840 Apical Ampulla oviduct In situ hybridization "The cellular location of the oviduct protein mRNA varied depending on the position of epithelial cells in longitudinal mucosal folds. In epithelial cells at the free margins of folds, the oviduct protein mRNA was contained predominantly in the apical cytoplasm, although specific reaction product was present in peri-nuclear regions (Fig. 2A). " RLID00037412 RLGI00689 Nucleobindin precursor mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00037413 RLGI00691 nRCC mRNA Drosophila melanogaster 25565208 Mitochondrion HEK293T Fluorescence in situ hybridization "In HEK293T cells, the nRCC mRNAs homologous to those regulated by PINK1 in flies were found in highly purified mito (Figure 2A, B; S2A). " RLID00037414 RLGI00692 NNOS mRNA Rattus norvegicus 11020337 Nucleus Brain In situ hybridization "NNOS mRNA was not found in the normal ND neurons, but was shown in the normal RN (red nucleus) neurons. The normal RN neurons displayed mild nNOS mRNA expression (Fig. 12a). " RLID00037415 RLGI00693 NK-1 mRNA Felis catus 10521569 Cytoplasm ForeBrain In situ hybridization NK-1 mRNA was localized in the cytoplasm but not nuclei of cat forebrain neurons. RLID00037416 RLGI00694 Neutral amino acid transporter mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00037417 RLGI00695 NEP mRNA Mus musculus 8026647 Cytoplasm Enterocytes In situ hybridization "Interestingly, there was only one peak position for NEP mRNA which was located in the cytoplasm above the nucleus. " RLID00037418 RLGI00696 NDM29 lncRNA Homo sapiens 20581224 Cytoplasm Neuroblastoma cell Microarray "The subcellular localization of NDM29 was then determined by real-time RT-PCR, measuring the amount of NDM29 RNA in the cytosolic and in the nuclear fractions of SKNBE2 cells. We found 71% of NDM29 RNA in the cytosol and 29% in the nucleus. " RLID00037419 RLGI00696 NDM29 lncRNA Homo sapiens 20581224 Nucleus Neuroblastoma cell Microarray "The subcellular localization of NDM29 was then determined by real-time RT-PCR, measuring the amount of NDM29 RNA in the cytosolic and in the nuclear fractions of SKNBE2 cells. We found 71% of NDM29 RNA in the cytosol and 29% in the nucleus. " RLID00037420 RLGI00698 ncHoxD4 lncRNA Homo sapiens 23133536 Cytoplasm Breast cancer cell In situ hybridization "RNA probes for ncHoxA1, ncHoxD4, and HOTAIR were created and found to create a dot-like pattern in the cytoplasm surrounding the nucleus upon in situ hybridization (Figure 1). " RLID00037421 RLGI00699 ncHoxA1 lncRNA Homo sapiens 23133536 Cytoplasm Breast cancer cell In situ hybridization "RNA probes for ncHoxA1, ncHoxD4, and HOTAIR were created and found to create a dot-like pattern in the cytoplasm surrounding the nucleus upon in situ hybridization (Figure 1). " RLID00037422 RLGI00700 NADP-ME mRNA Nicotiana tabacum 24484954 Chloroplast Leaf qRT-PCR The amount of NADP-ME protein and transcription of mRNA for chloroplastic NADP-ME isoform were increased indicating their enhanced synthesis de novo. RLID00037423 RLGI00701 nad9 mRNA Solanum tuberosum 8614643 Mitochondrion Tubers In situ hybridization|Northern blot|RT-PCR "Using two primer pairs that will either specifically amplify the larger transcript or amplify both the larger and the smaller transcripts in RT-PCR analyses it was found that the larger nad9 transcripts are partially edited, while the smaller transcripts are fully edited. Both the larger and the smaller transcripts were found to be associated with mitochondrial polysomes. " RLID00037424 RLGI00702 Na+/Cl taurine transporter mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "In examining the relative distribution of mRNAs between the total and ER-associated RNA pools, mRNAs were categorized into three classes: mRNAs present in the ER-associated pool but below the limit of detection in total RNA (ER-membrane-enriched); mRNAs present in total RNA but absent in ER-associated RNA (cytosol-enriched); and mRNAs present in both pools, but enriched fourfold or greater in ER-associated RNA (ER membrane and cytosol; Fig. 5B; Table 2). In Table 2, 10 representative mRNAs from each class are listed. " RLID00037425 RLGI00703 Na+ channel mRNA mRNA Rattus norvegicus 8833997 Cell body GFL neuron In situ hybridization In situ hybridization with dissociated GFL neurons maintained in primary culture verified that Na+ channel mRNA is confined to the cell body. RLID00037426 RLGI00707 mtlrRNA rRNA Xenopus laevis 11784096 Germ plasm Oocyte In situ hybridization "The germ plasm is a specialized region of oocyte cytoplasm that contains determinants of germ cell fate. In Xenopus oocytes, the germ plasm is a part of the METRO region of mitochondrial cloud. It contains the germinal granules and a variety of coding and noncoding RNAs that include Xcat2, Xlsirts, Xdazl, DEADSouth, Xpat, Xwnt11, fatVg, B7/Fingers, C10/XFACS, and mitochondrial large and small rRNA. We analyzed the distribution of these 11 different RNAs within the various compartments of germ plasm during Xenopus oogenesis and development by using whole-mount electron microscopy in situ hybridization. " RLID00037427 RLGI00707 mtlrRNA rRNA Xenopus laevis 11784096 Mitochondrion Oocyte In situ hybridization "The fourth pattern included mtlrRNA and mtsrRNA that were present in the mitochondria and also in the cytoplasm (Table 1; Kloc et al., 2001b). " RLID00037428 RLGI00707 mtlrRNA rRNA Xenopus laevis 11784096 Cytoplasm Oocyte In situ hybridization "The fourth pattern included mtlrRNA and mtsrRNA that were present in the mitochondria and also in the cytoplasm (Table 1; Kloc et al., 2001b). " RLID00037429 RLGI00707 mtsrRNA rRNA Xenopus laevis 11784096 Germ plasm Oocyte In situ hybridization "The germ plasm is a specialized region of oocyte cytoplasm that contains determinants of germ cell fate. In Xenopus oocytes, the germ plasm is a part of the METRO region of mitochondrial cloud. It contains the germinal granules and a variety of coding and noncoding RNAs that include Xcat2, Xlsirts, Xdazl, DEADSouth, Xpat, Xwnt11, fatVg, B7/Fingers, C10/XFACS, and mitochondrial large and small rRNA. We analyzed the distribution of these 11 different RNAs within the various compartments of germ plasm during Xenopus oogenesis and development by using whole-mount electron microscopy in situ hybridization. " RLID00037430 RLGI00707 mtsrRNA rRNA Xenopus laevis 11784096 Mitochondrion Oocyte In situ hybridization "The fourth pattern included mtlrRNA and mtsrRNA that were present in the mitochondria and also in the cytoplasm (Table 1; Kloc et al., 2001b). " RLID00037431 RLGI00707 mtsrRNA rRNA Xenopus laevis 11784096 Cytoplasm Oocyte In situ hybridization "The fourth pattern included mtlrRNA and mtsrRNA that were present in the mitochondria and also in the cytoplasm (Table 1; Kloc et al., 2001b). " RLID00037432 RLGI00710 MRPL16 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037433 RLGI00711 MRP RNA mRNA Saccharomyces cerevisiae 20691904 Mitochondrion Yeast RT-PCR "Figure 4: PNPASE Augments RNase P, 5S rRNA, and MRP RNA Import into Yeast Mitochondria. Data are collected from Figur 4. " RLID00037434 RLGI00712 MRAK088388 lncRNA Rattus norvegicus 24702795 Cytoplasm Lung tissue qRT-PCR|In situ hybridization "MRAK088388 and MRAK081523 were analysed as long-intergenic non-coding RNAs (lincRNAs), and identified as orthologues of mouse lncRNAs AK088388 and AK081523, respectively. qRT-PCR and in situ hybridization (ISH) showed that they were significantly up-regulated, and located in the cytoplasm of interstitial lung cells. " RLID00037435 RLGI00713 MRAK081523 lncRNA Rattus norvegicus 24702795 Cytoplasm Lung tissue qRT-PCR|In situ hybridization "MRAK088388 and MRAK081523 were analysed as long-intergenic non-coding RNAs (lincRNAs), and identified as orthologues of mouse lncRNAs AK088388 and AK081523, respectively. qRT-PCR and in situ hybridization (ISH) showed that they were significantly up-regulated, and located in the cytoplasm of interstitial lung cells. " RLID00037436 RLGI00714 MOCS2B mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037437 RLGI00715 MHM lncRNA Gallus gallus 22546690 Nucleus Embryonic cell In situ hybridizationq|Northern blot "The long non-coding RNA, MHM, is localised in the nucleus of female chick embryos. " RLID00037438 RLGI00716 MDH mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037439 RLGI00717 MAP2C mRNA Mus musculus 8647897 Cell body Mature neuron In situ hybridization "Initially, each was detected in axons and dendrites, although tau persisted only in axons, whereas MAP2C and MAP2 were restricted to cell bodies and dendrites. " RLID00037440 RLGI00717 MAP2C mRNA Mus musculus 8647897 Dendrite Mature neuron In situ hybridization "Initially, each was detected in axons and dendrites, although tau persisted only in axons, whereas MAP2C and MAP2 were restricted to cell bodies and dendrites. " RLID00037441 RLGI00719 macho 1 mRNA Ascidian 14573512 Cell cortex Eggs|Zygotes|Embryo In situ hybridization The postplasmic RNAs macho 1 and HrPEM were located on the cER network and could be detached from it. We also suggest that the RNAs segregate and concentrate in posterior blastomeres through compaction of the cER to form the CAB. RLID00037442 RLGI00720 Lys-AAG tRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "In cellular RNA, we observed fragments located at the 5�or 3′end of the mature tRNA (Table 3). However, the most abundant tRNA hits in shuttle RNA were all located at the 5′end of mature tRNAs. Data are collected from Table 3: Most abundant tRNA fragments in cellular and shuttle RNA. " RLID00037443 RLGI00721 Lys-AAA tRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "In cellular RNA, we observed fragments located at the 5�or 3′end of the mature tRNA (Table 3). However, the most abundant tRNA hits in shuttle RNA were all located at the 5′end of mature tRNAs. Data are collected from Table 3: Most abundant tRNA fragments in cellular and shuttle RNA. " RLID00037444 RLGI00722 Lys tRNA Cricetulus griseus 16644724 Nucleus Ovary cell RT-PCR|Northern blot "FIGURE 5. XBP1 mRNA splicing occurs in the cytoplasm. CHO/mXBP1ΔC(un)-d2EGFP reporter cells were treated with Tm for 4 h and then RNAs were isolated from total (T), nuclear (N), and cytoplasmic (C) fractions and used for RT-PCR analysis (A). To demonstrate the quality of the fractionation, nucleoplasmic (N) and cytoplasmic (C) RNAs were monitored by Northern blot analysis for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (B), tRNALys (C), and U6 small nuclear RNA (D). All RNAs shown were isolated from the same experiment. GADPH is shown as a loading control (E). The image of RNA stained with ethidium bromide in a formaldehyde/agarose gel demonstrates the quality of the RNA. N.B. indicates Northern blot. " RLID00037445 RLGI00722 Lys tRNA Cricetulus griseus 16644724 Cytoplasm Ovary cell RT-PCR|Northern blot "FIGURE 5. XBP1 mRNA splicing occurs in the cytoplasm. CHO/mXBP1ΔC(un)-d2EGFP reporter cells were treated with Tm for 4 h and then RNAs were isolated from total (T), nuclear (N), and cytoplasmic (C) fractions and used for RT-PCR analysis (A). To demonstrate the quality of the fractionation, nucleoplasmic (N) and cytoplasmic (C) RNAs were monitored by Northern blot analysis for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (B), tRNALys (C), and U6 small nuclear RNA (D). All RNAs shown were isolated from the same experiment. GADPH is shown as a loading control (E). The image of RNA stained with ethidium bromide in a formaldehyde/agarose gel demonstrates the quality of the RNA. N.B. indicates Northern blot. " RLID00037446 RLGI00724 LUAT lncRNA Mus musculus 24365181 Cytoplasm Thymocytes Next-generation sequencing "Assessment of subcellular localization of LUATs using recently published RNA-seq data obtained from fractionated chromatin-associated, nucleoplasmic and cytoplasmic transcripts (Bhatt et al.), showed that they remains mainly associated with the chromatin fraction (Additional file 5: Figure S3), " RLID00037447 RLGI00724 LUAT lncRNA Mus musculus 24365181 Nucleoplasm Thymocytes Next-generation sequencing "Assessment of subcellular localization of LUATs using recently published RNA-seq data obtained from fractionated chromatin-associated, nucleoplasmic and cytoplasmic transcripts (Bhatt et al.), showed that they remains mainly associated with the chromatin fraction (Additional file 5: Figure S3), " RLID00037448 RLGI00724 LUAT lncRNA Mus musculus 24365181 Nucleus Thymocytes Next-generation sequencing "Assessment of subcellular localization of LUATs using recently published RNA-seq data obtained from fractionated chromatin-associated, nucleoplasmic and cytoplasmic transcripts (Bhatt et al.), showed that they remains mainly associated with the chromatin fraction (Additional file 5: Figure S3), " RLID00037449 RLGI00727 lnc-996 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037450 RLGI00727 lnc-996 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037451 RLGI00729 lnc-994 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037452 RLGI00729 lnc-994 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037453 RLGI00731 lnc-962 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037454 RLGI00731 lnc-962 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037455 RLGI00733 lnc-861 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037456 RLGI00733 lnc-861 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037457 RLGI00735 lnc-803 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037458 RLGI00735 lnc-803 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037459 RLGI00737 lnc-793 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037460 RLGI00737 lnc-793 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037461 RLGI00739 lnc-776 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037462 RLGI00739 lnc-776 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037463 RLGI00741 lnc-686b lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037464 RLGI00741 lnc-686b lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037465 RLGI00743 lnc-686a lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037466 RLGI00743 lnc-686a lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037467 RLGI00745 lnc-666 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037468 RLGI00745 lnc-666 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037469 RLGI00747 lnc-613 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037470 RLGI00747 lnc-613 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037471 RLGI00749 lnc-561 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037472 RLGI00749 lnc-561 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037473 RLGI00751 lnc-509 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037474 RLGI00751 lnc-509 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037475 RLGI00753 lnc-460 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037476 RLGI00753 lnc-460 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037477 RLGI00755 lnc-456b lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037478 RLGI00755 lnc-456b lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037479 RLGI00757 lnc-456a lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037480 RLGI00757 lnc-456a lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037481 RLGI00759 lnc-405 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037482 RLGI00759 lnc-405 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037483 RLGI00761 lnc-389 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037484 RLGI00761 lnc-389 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037485 RLGI00763 lnc-312b lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037486 RLGI00763 lnc-312b lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037487 RLGI00765 lnc-312a lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037488 RLGI00765 lnc-312a lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037489 RLGI00767 lnc-31 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037490 RLGI00767 lnc-31 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037491 RLGI00769 lnc-267 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037492 RLGI00769 lnc-267 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037493 RLGI00771 lnc-254 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037494 RLGI00771 lnc-254 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037495 RLGI00773 lnc-214 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037496 RLGI00773 lnc-214 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037497 RLGI00775 lnc-182 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037498 RLGI00775 lnc-182 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037499 RLGI00777 lnc-165 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037500 RLGI00777 lnc-165 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037501 RLGI00779 lnc-149 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037502 RLGI00779 lnc-149 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037503 RLGI00781 lnc-083 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037504 RLGI00781 lnc-083 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037505 RLGI00783 lnc-082 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037506 RLGI00783 lnc-082 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037507 RLGI00785 lnc-058 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037508 RLGI00785 lnc-058 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037509 RLGI00787 lnc-049 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037510 RLGI00787 lnc-049 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037511 RLGI00789 lnc-023 lncRNA Mus musculus 25512605 Nucleus C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037512 RLGI00789 lnc-023 lncRNA Mus musculus 25512605 Cytoplasm C2C12 cell qRT-PCR "FIG 3: Subcellular distribution of the novel lncRNAs. Histograms show the quantifications of sqRT-PCR performed on RNA extracted from cytoplasmic (Cyt) and nuclear (N) fractions of myoblasts maintained under GM or DM (day 2) conditions. Results of a representative experiment are shown in Fig. S3 in the supplemental material. (A) Graphs show the cytoplasmic/nuclear partitioning of the lncRNAs, considering their expression conditions in GM or DM. The red shadow highlights the region of the graph occupied by lncRNAs with a bipartite subcellular distribution as defined by cytoplasmic/nuclear partitioning of control transcripts (see below). (B) Graphs show the quantification of the subcellular localization of control transcripts used to test the quality of the cytoplasmic/nuclear fractionation under GM or DM conditions: precursor (pre-Gapdh) and mature Gapdh mRNA, Rnu1-2 (U1) snRNA, and Snord55 (sno55). The red shadow defines the cytoplasmic/nuclear partition region in which no evident cytoplasmic/nuclear distribution can be assigned. Error bars represent standard deviations of data from multiple independent experiments. " RLID00037513 RLGI00794 lincRNA-uc003opf.1 lncRNA Homo sapiens 23872665 Cytoplasm Esophageal squamous cell qRT-PCR "To determine the cellular localization of lincRNA-uc003opf.1, we fractionated ESCC cell lines into nuclear and cytoplasmic fractions. We can thoroughly separate nucleus from cytoplasm, as indicated by the results showing that GAPDH mRNA was exclusively detected in the cytoplasmic fraction, whereas the transcriptional level of nucleus-retained U6 was predominantly found in the nuclear fraction. For EC9706 cell line, qRT-PCR analysis revealed that (mean +/- SD) 40.3 +/- 17.3% lincRNA-uc003opf.1 was detected in the nuclear fraction, and 59.7 +/- 17.3% resided in the cytoplasm fraction. We got the similar results in TE-1 cell line that 39.7 +/- 9.5% and 60.3 +/- 9.5% lincRNA-uc003opf.1 were detected in the nuclear fraction and the cytoplasm fraction, respectively (Figure 1A). " RLID00037514 RLGI00794 lincRNA-uc003opf.1 lncRNA Homo sapiens 23872665 Nucleus Esophageal squamous cell qRT-PCR "To determine the cellular localization of lincRNA-uc003opf.1, we fractionated ESCC cell lines into nuclear and cytoplasmic fractions. We can thoroughly separate nucleus from cytoplasm, as indicated by the results showing that GAPDH mRNA was exclusively detected in the cytoplasmic fraction, whereas the transcriptional level of nucleus-retained U6 was predominantly found in the nuclear fraction. For EC9706 cell line, qRT-PCR analysis revealed that (mean +/- SD) 40.3 +/- 17.3% lincRNA-uc003opf.1 was detected in the nuclear fraction, and 59.7 +/- 17.3% resided in the cytoplasm fraction. We got the similar results in TE-1 cell line that 39.7 +/- 9.5% and 60.3 +/- 9.5% lincRNA-uc003opf.1 were detected in the nuclear fraction and the cytoplasm fraction, respectively (Figure 1A). " RLID00037515 RLGI00796 LD42239-dg mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037516 RLGI00796 LD42239-dg mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037517 RLGI00798 LD40851-dg mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037518 RLGI00798 LD40851-dg mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037519 RLGI00798 LD40851-dg mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037520 RLGI00801 LD40851-dg mRNA Drosophila melanogaster 25838129 Nucleus Oocyte In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037521 RLGI00801 LD40851-dg mRNA Drosophila melanogaster 25838129 Posterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037522 RLGI00803 LD26231-dg mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037523 RLGI00803 LD26231-dg mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037524 RLGI00805 lacZ mRNA Saccharomyces cerevisiae 15899876 Cellular bud Yeast In situ hybridization Measurement of the percentage of budding yeast cells with bud-localized lacZ mRNA fused to wild-type or mutated localization elements. RLID00037525 RLGI00806 kiss2 mRNA Anoplopoma fimbria 26386183 Cytoplasm Oocyte In situ hybridization "In situ hybridization revealed that kiss2 mRNA was localized to cytoplasm of perinucleolus stage oocytes, suggesting it could play a local role in oogenesis or could be synthesized and stored within oocytes as maternal mRNA. " RLID00037526 RLGI00807 Kinesin mRNA Doryteuthis pealeii 8207422 Axon Loligo pealii In situ hybridization Kinesin mRNA is a component of a select group of mRNAs present in the squid giant axon. RLID00037527 RLGI00808 IVD mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037528 RLGI00809 InsP3receptor mRNA Rattus norvegicus 7773006 Dendrite Neuron In situ hybridization "Table 1. As of 1994, mRNAs that have been localized within dendrites by in situ hybridization. Data are collected from Table 1. " RLID00037529 RLGI00810 inf5 mRNA Drosophila melanogaster 25838129 Anterior Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037530 RLGI00811 inf195 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037531 RLGI00812 inf183 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037532 RLGI00813 inf126 mRNA Drosophila melanogaster 25838129 Cytoplasm Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037533 RLGI00813 inf126 mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037534 RLGI00815 IDH mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037535 RLGI00816 Hsp90 mRNA Mus musculus 12923260 Ribosome B cell S1 nuclease protection assays "Oligonucleotide probes were designed to hybridize with mRNAs encoding representative members of three classes of protein: soluble (GAPDH, Hsp90, and LDH), ER resident membrane (Sec61a and calnexin), and ER resident lumenal (BiP, calreticulin, and GRP94). " RLID00037536 RLGI00817 hSNF2a mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00037537 RLGI00818 hsa-miRPlus_28993 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037538 RLGI00819 hsa-miRPlus_28575 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037539 RLGI00820 hsa-miRPlus_28431 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037540 RLGI00821 hsa-miRPlus_28232 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037541 RLGI00822 hsa-miRPlus_27839 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037542 RLGI00823 hsa-miRPlus_27564 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037543 RLGI00824 hsa-miRPlus_27561 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037544 RLGI00825 hsa-miRPlus_27560 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037545 RLGI00826 hsa-miRPlus_21472 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037546 RLGI00827 hsa-miRPlus_17952 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037547 RLGI00828 hsa-miRPlus_17945 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037548 RLGI00829 hsa-miRPlus_17921 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037549 RLGI00830 hsa-miRPlus_17900 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037550 RLGI00831 hsa-miRPlus_17896 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037551 RLGI00832 hsa-miRPlus_17890 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037552 RLGI00833 hsa-miRPlus_17869 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037553 RLGI00834 hsa-miRPlus_17865 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037554 RLGI00835 hsa-miRPlus_17861 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037555 RLGI00836 hsa-miRPlus_17832 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037556 RLGI00837 hsa-miRPlus_11201 miRNA Homo sapiens 24009880 Exosome Mast cell Microarray "In the exosomes, 116 microRNAs were identified and 134 microRNAs were identified in the donor HMC-1 cells (Fig. 3a and 3b, Table I and Additional Information, Table S16). Data are collected from Table 1. " RLID00037557 RLGI00838 hsa-miRPIus_42526 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00037558 RLGI00839 hsa-miRPIus_42487 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00037559 RLGI00840 hsa-miRPIus_17858 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00037560 RLGI00841 hsa-miRPIus_17848 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00037561 RLGI00842 hsa-miRPIus_17841 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00037562 RLGI00843 hsa-miRPIus_17824 miRNA Homo sapiens 22529849 Exosome Saliva - Table 1: Exosomal miRNAs as potential biomarkers and therapeutic targets. Data are collected from Table 1. RLID00037563 RLGI00844 hsa-miR-BART18-3p miRNA Homo sapiens 24858071 Circulating Serum Microarray "Prediction of targets of differentially expressed miRNA and function annotation in peripheral blood of GBM patients. To understand the potential functions of significantly differentially expressed miRNA in the GBM, and to further explore the function of these predicted target genes, we selected the most upregulated coherent 12 miRNAs (hsa-miR-4726-5p, hsa-miR-1255b-2-3p, hsa-miR-340-5p, hsa-miR-4275, hsa-miR-4712-3p, hsa-miR-576-5p, hsa-miR-1299, hsa-miR-4268, hsa-miR-3591-5p, hsa-miR-626, hsa-miR-BART18-3p, hsa-miR-3169), and the most downregulated coherent 8 miRNAs (hsa-miR-320b, hsa-let-7g-5p, hsa-miR-486-5p, hsa-miR-7-5p, hsa-miR-4524b-5p, hsa-miR-3171, hsa-miR-1246, hsa-miR-1273g-3p) to perform Gene Ontology analysis and pathway analysis. " RLID00037564 RLGI00845 HrWnt-5 mRNA mRNA Xenopus laevis 9694628 Vegetal Embryo In situ hybridization "HrWnt-5mRNA is present in the vegetal cortex in unfertilized eggs. After fertilization, HrWnt-5 mRNA movesto the equatorial region to form a crescent-like structure. after which the mRNA is concentrated inthe posteriormost region of the embryo. " RLID00037565 RLGI00846 Hr-PEM1 mRNA Ascidian 16207760 Cell cortex Embryo RT-PCR "The Hr-PEM1 mRNA-rich region always coincided with the small cER-rich region (Fig. 8B, arrowheads). These observations indicate that POPK-1 is required for proper concentration and positioning of cER, and that it affects the mRNA distribution via cER movements. " RLID00037566 RLGI00846 Hr-PEM1 mRNA Ascidian 18062956 Cell cortex Oocyte In situ hybridization We have previously shown that PEM-1 mRNA is associated with a network of rough cortical Endoplasmic Reticulum (cER) polarized along the animal-vegetal (a-v) axis forming a cER-mRNA domain in mature oocytes. RLID00037567 RLGI00848 Hr-PEM mRNA Ascidian 17570671 Posterior Embryo Immunostaining "Furthermore, detailed analysis of the Hr-PEM knockdown embryos revealed that Hr-PEM also controls orientation of the cleavage planes as early as at the second and third cleavages, which are almost equal in size, by attracting one centrosome to the posterior-vegetal region where Hr-PEM mRNA and the protein are localized. " RLID00037568 RLGI00849 HrPEM mRNA Ascidian 14573512 Cell cortex Eggs|Zygotes|Embryo In situ hybridization The postplasmic RNAs macho 1 and HrPEM were located on the cER network and could be detached from it. We also suggest that the RNAs segregate and concentrate in posterior blastomeres through compaction of the cER to form the CAB. RLID00037569 RLGI00850 HL05382-dg mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037570 RLGI00851 Histone deacetylase mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00037571 RLGI00852 Heme synthetase mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00037572 RLGI00853 HDV RNA mRNA Homo sapiens 9622127 Nucleoplasm Hepatoma cell In situ hybridizationq|Microscopy "The human hepatoma cell line Huh7 was stably transfected with wild-type HDV cDNA and the viral RNAs were localized by in situ hybridization and fluorescence confocal microscopy. HDV RNA is detected throughout the nucleoplasm, with additional concentration in focal structures closely associated with nuclear speckles or clusters of interchromatin granules. " RLID00037573 RLGI00853 HDV RNA mRNA Homo sapiens 9622127 Nucleus Hepatoma cell In situ hybridizationq|Microscopy "The human hepatoma cell line Huh7 was stably transfected with wild-type HDV cDNA and the viral RNAs were localized by in situ hybridization and fluorescence confocal microscopy. HDV RNA is detected throughout the nucleoplasm, with additional concentration in focal structures closely associated with nuclear speckles or clusters of interchromatin granules. " RLID00037574 RLGI00855 HCRSV RNA mRNA Hibiscus cannabinus 23155403 Nucleus Seedling In situ hybridization "Hibiscus chlorotic ringspot virus (HCRSV) RNA was detected in the nucleus of infected cells, as shown by fluorescent in situ hybridization. " RLID00037575 RLGI00856 HAC1p mRNA Homo sapiens 12923260 Endoplasmic reticulum Jurkat cell - "The Hac1p mRNA, which displays noncanonical partitioning to the endoplasmic reticulum, is one useful example of an mRNA whose localization may serve important roles in metabolic regulation. " RLID00037576 RLGI00857 H2 mRNA Cavia porcellus 9284338 Axon Brain In situ hybridization "In many brain areas, the distribution of the H2 receptor and its messenger RNAs appeared to parallel that known for histaminergic axons. " RLID00037577 RLGI00858 GUS mRNA Oryza sativa 11048726 Endoplasmic reticulum Endosperm RT-PCR "While GUS transcripts are localized to the PB-ER in GUS::prolamine plants (Fig. 3b), such a distribution pattern was not evident in GUS::glutelin plants (Fig. 3c). These results confirm the RNA signal dependence of prolamine RNA localization to the PB-ER. " RLID00037578 RLGI00859 granzymeA mRNA Homo sapiens 2157676 Cytoplasm LAK cell In situ hybridization The presence of PI and granzymeA mRNA in the cytoplasm was confirmed by in situ hybridization using specific antisense probes. RLID00037579 RLGI00860 GPXR mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037580 RLGI00861 Gly-GGY tRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "In cellular RNA, we observed fragments located at the 5â€?or 3′end of the mature tRNA (Table 3). However, the most abundant tRNA hits in shuttle RNA were all located at the 5′end of mature tRNAs. Data are collected from Table 3: Most abundant tRNA fragments in cellular and shuttle RNA. " RLID00037581 RLGI00862 Gly-GGG tRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037582 RLGI00862 Gly-GGG tRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037583 RLGI00864 Gly-GGC tRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037584 RLGI00864 Gly-GGC tRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037585 RLGI00866 Gly-GGA tRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "In cellular RNA, we observed fragments located at the 5â€?or 3′end of the mature tRNA (Table 3). However, the most abundant tRNA hits in shuttle RNA were all located at the 5′end of mature tRNAs. Data are collected from Table 3: Most abundant tRNA fragments in cellular and shuttle RNA. " RLID00037586 RLGI00867 Gly-GCCv2 tRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037587 RLGI00868 Gly-GCCv1 tRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037588 RLGI00869 Gly-CCCv2 tRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037589 RLGI00869 Gly-CCCv2 tRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037590 RLGI00871 Gly-CCCv1 tRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037591 RLGI00871 Gly-CCCv1 tRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037592 RLGI00873 glutelin mRNA Oryza sativa 11048726 Endoplasmic reticulum Endosperm RT-PCR These results indicate that prolamine and glutelin RNAs are distributed on spatially distinct ER subdomains and that prolamine RNAs are localized specifically to the prolamine protein bodies. RLID00037593 RLGI00873 glutelin mRNA Oryza sativa 14523246 Endoplasmic reticulum Endosperm RT-PCR "Prolamine and glutelin RNAs are localized to two subdomains of the cortical endoplasmic reticulum (ER), the protein body ER and the cisternal ER, in developing rice seeds. " RLID00037594 RLGI00873 glutelin mRNA Oryza sativa 19605415 Endoplasmic reticulum Endosperm RT-PCR "Fig. 1 shows the schematic representation of the 10 kDa delta-zein transgenes containing various segments of the glutelin transcript sequences as well as their spatial distribution to the PB-ER and cisternal ER as viewed by in situ RT-PCR using the 10 kDa delta-zein-specific primers. In the absence of glutelin sequences, the 10 kDa delta-zein RNA is targeted to the PB-ER in transgenic rice endosperm cells (Hamada et al. 2003b). The presence of intact glutelin transcript sequences as part of the 3â€?UTR resulted in re-directing RNA targeting to the cisternal ER. " RLID00037595 RLGI00876 Glu-GAG tRNA Mus musculus 22821563 Extracellular vesicle T cell Next-generation sequencing "In cellular RNA, we observed fragments located at the 5â€?or 3′end of the mature tRNA (Table 3). However, the most abundant tRNA hits in shuttle RNA were all located at the 5′end of mature tRNAs. Data are collected from Table 3: Most abundant tRNA fragments in cellular and shuttle RNA. " RLID00037596 RLGI00877 Glu-GAG tRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037597 RLGI00877 Glu-GAG tRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037598 RLGI00879 Glu-GAA tRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037599 RLGI00879 Glu-GAA tRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037600 RLGI00881 Glu-CTCv2 tRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037601 RLGI00881 Glu-CTCv2 tRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037602 RLGI00883 Glu-CTCv1 tRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037603 RLGI00883 Glu-CTCv1 tRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037604 RLGI00885 Glu-CTC tRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037605 RLGI00885 Glu-CTC tRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037606 RLGI00887 GH-RBP mRNA Rattus norvegicus 8022524 Cytoplasm Anterior pituitary In situ hybridization "RGH-RBP mRNA was readily identified in the cytoplasmic matrix, associated with the endoplasmic reticulum and the nucleus of the somatotrophs, the lactotrophs and the gonadotrophs. " RLID00037607 RLGI00888 GH23462 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037608 RLGI00889 GH06646-dg mRNA Drosophila melanogaster 25838129 Nucleus Embryo In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037609 RLGI00890 GGGGCC microsatellite repeat RNA mRNA Rattus norvegicus 26650351 Cell body Spinal cord neuron In situ hybridization "We confirmed that iPSNs contained nuclear GGGGCC RNA foci, but also found that 78 ± 12% SD (carrier 1; n=25 neurons) and 75 ± 11% SD (carrier 2; n=23) of iPSNs that contained nuclear GGGGCC RNA foci also contained neuritic GGGGCC RNA particles by in situ hybridization (Figure 1A,L). The GGGGCC RNA particles were detected both proximally and distally at over 45 μm from the cell body in neurites and were, in some cases, lined up, consistent with possible association with a cytoskeletal track (Figure 1A-B). In addition, GGGGCC repeat RNA particles were detected in the cell body in nearly all iPSNs that also contained GGGGCC RNA nuclear foci (Figure 1C, also Almeida et al., 2013). " RLID00037610 RLGI00890 GGGGCC microsatellite repeat RNA mRNA Rattus norvegicus 26650351 Nucleus Spinal cord neuron In situ hybridization "We confirmed that iPSNs contained nuclear GGGGCC RNA foci, but also found that 78 ± 12% SD (carrier 1; n=25 neurons) and 75 ± 11% SD (carrier 2; n=23) of iPSNs that contained nuclear GGGGCC RNA foci also contained neuritic GGGGCC RNA particles by in situ hybridization (Figure 1A,L). The GGGGCC RNA particles were detected both proximally and distally at over 45 μm from the cell body in neurites and were, in some cases, lined up, consistent with possible association with a cytoskeletal track (Figure 1A-B). In addition, GGGGCC repeat RNA particles were detected in the cell body in nearly all iPSNs that also contained GGGGCC RNA nuclear foci (Figure 1C, also Almeida et al., 2013). " RLID00037611 RLGI00892 gD mRNA Bovine herpesvirus 1 25529439 Cytoplasm COS-7 cell qRT-PCR "We demonstrated interactions of VP8 with bICP0, gB, gC and gD mRNAs by RNA-immunoprecipitation and qPCR, both in the nucleus and cytoplasm of COS-7 cells. " RLID00037612 RLGI00892 gD mRNA Bovine herpesvirus 1 25529439 Nucleus COS-7 cell qRT-PCR "We demonstrated interactions of VP8 with bICP0, gB, gC and gD mRNAs by RNA-immunoprecipitation and qPCR, both in the nucleus and cytoplasm of COS-7 cells. " RLID00037613 RLGI00894 gC mRNA Bovine herpesvirus 1 25529439 Cytoplasm COS-7 cell qRT-PCR "We demonstrated interactions of VP8 with bICP0, gB, gC and gD mRNAs by RNA-immunoprecipitation and qPCR, both in the nucleus and cytoplasm of COS-7 cells. " RLID00037614 RLGI00894 gC mRNA Bovine herpesvirus 1 25529439 Nucleus COS-7 cell qRT-PCR "We demonstrated interactions of VP8 with bICP0, gB, gC and gD mRNAs by RNA-immunoprecipitation and qPCR, both in the nucleus and cytoplasm of COS-7 cells. " RLID00037615 RLGI00896 gB mRNA Bovine herpesvirus 1 25529439 Cytoplasm COS-7 cell qRT-PCR "We demonstrated interactions of VP8 with bICP0, gB, gC and gD mRNAs by RNA-immunoprecipitation and qPCR, both in the nucleus and cytoplasm of COS-7 cells. " RLID00037616 RLGI00896 gB mRNA Bovine herpesvirus 1 25529439 Nucleus COS-7 cell qRT-PCR "We demonstrated interactions of VP8 with bICP0, gB, gC and gD mRNAs by RNA-immunoprecipitation and qPCR, both in the nucleus and cytoplasm of COS-7 cells. " RLID00037617 RLGI00898 GASS lncRNA Homo sapiens 25630241 Nucleus Hela cell Florescence micrograph "Figure 2: LncRNAs exhibit a variety of cellular localization patterns. Florescence micrographs of representative expressing cells for each of 34 lncRNAs with a validated probe set. LncRNA-cell pairs are classified to cellular localization types I to V as described in the Methods (marked by their border color). Magenta stars mark five lncRNAs that are presented in two different cell types and two different classes (see same row for comparison). Scale bar, 5 um; when a scale bar is not specified, reference the scale bar within the top left image. Top panel: fraction of each classification for each type across the full set of 70 valid lncRNA-cell pairs imaged. Data are collected from Figure 2. " RLID00037618 RLGI00899 GAPDH mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037619 RLGI00900 ferritin H chain mRNA mRNA Rattus norvegicus 10860832 Cell body Hippocampus In situ hybridization "The ferritin H chain mRNA was found to be highly enriched in the synaptosomes. In situ hybridization for the ferritin H chain mRNA in the cultured dissociated neurons and in the hippocampal brain slices demonstrated its existence in the dendritic region. These data clearly indicate the selective translocation of the ferritin H chain mRNA into the dendrites and suggested the local expression of ferritin at the synapse. Therefore, the mRNAs of the ferritin H chain are located in the cell bodies and in the dendrites of the dentate gyrus neurons. " RLID00037620 RLGI00900 ferritin H chain mRNA mRNA Rattus norvegicus 10860832 Dendrite Hippocampus In situ hybridization "The ferritin H chain mRNA was found to be highly enriched in the synaptosomes. In situ hybridization for the ferritin H chain mRNA in the cultured dissociated neurons and in the hippocampal brain slices demonstrated its existence in the dendritic region. These data clearly indicate the selective translocation of the ferritin H chain mRNA into the dendrites and suggested the local expression of ferritin at the synapse. Therefore, the mRNAs of the ferritin H chain are located in the cell bodies and in the dendrites of the dentate gyrus neurons. " RLID00037621 RLGI00902 FAK1 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037622 RLGI00903 ERAIm454-557 mRNA Homo sapiens 26068456 Cytoplasm MCF-7 cell RT-PCR "In the acute ER stress condition, the spliced mRNA of both ERAIm454-557 and endogenous XBP1 was significantly increased in the cytoplasm but not in the nucleus. " RLID00037623 RLGI00904 elastase I mRNA Rattus norvegicus 6918221 Endoplasmic reticulum Acinar cell In situ hybridization "The mRNA for elastase I is localized in the rough endoplasmic reticulum of acinar cells, as expected for the site of synthesis of an exocrine secretory enzyme. " RLID00037624 RLGI00905 eIF4E1 mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037625 RLGI00906 eEF1-Alpha mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037626 RLGI00907 EEF1A1 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037627 RLGI00908 ecNOS mRNA Rattus norvegicus 9290578 Cytoplasm Vascular endothelial cell In situ hybridization In situ hybridization showed that ecNOS mRNA was expressed in the cytoplasm of vascular endothelial cells in control and endotoxin-treated rats. RLID00037628 RLGI00909 EBER-2 mRNA Human herpesvirus 4 1332043 Nucleus Raji cell In situ hybridization "In situ hybridization of fluorescent oligodeoxynucleotides complementary to either EBER-1 or EBER-2 in Raji cells gave a strong pattern of staining, as illustrated in Fig. 1. Both probes revealed an essentially identical subcellular distribution for the two RNAs, with staining of both nucleus and cytoplasm. " RLID00037629 RLGI00909 EBER-2 mRNA Human herpesvirus 4 1332043 Cytoplasm Raji cell In situ hybridization "In situ hybridization of fluorescent oligodeoxynucleotides complementary to either EBER-1 or EBER-2 in Raji cells gave a strong pattern of staining, as illustrated in Fig. 1. Both probes revealed an essentially identical subcellular distribution for the two RNAs, with staining of both nucleus and cytoplasm. " RLID00037630 RLGI00911 EBER-1 mRNA Human herpesvirus 4 1332043 Cytoplasm Raji cell In situ hybridization "In situ hybridization of fluorescent oligodeoxynucleotides complementary to either EBER-1 or EBER-2 in Raji cells gave a strong pattern of staining, as illustrated in Fig. 1. Both probes revealed an essentially identical subcellular distribution for the two RNAs, with staining of both nucleus and cytoplasm. " RLID00037631 RLGI00911 EBER-1 mRNA Human herpesvirus 4 1332043 Nucleus Raji cell In situ hybridization "In situ hybridization of fluorescent oligodeoxynucleotides complementary to either EBER-1 or EBER-2 in Raji cells gave a strong pattern of staining, as illustrated in Fig. 1. Both probes revealed an essentially identical subcellular distribution for the two RNAs, with staining of both nucleus and cytoplasm. " RLID00037632 RLGI00913 E2 snoRNA Rattus norvegicus 19628621 Nucleolus Myoblast qRT-PCR "Thus, a known snoRNA, E2 (Mishra and Eliceiri 1997), was present at highest levels in the nucleolus-enriched fraction, while a Ro small RNA family member, Y1 RNA, was detected at highest levels in the cytoplasmic fraction, as expected for this known cytoplasm-concentrated RNA species (Fig. 1B;Hendrick et al. 1981). " RLID00037633 RLGI00914 E19 mRNA Rattus norvegicus 9724458 Axon Olfactory In situ hybridization We had previous evidence that between E13 and E19 CGRP mRNA was present at the level of olfactory axons but the resolution of light-microscope in situ hybridization did not permit the axons to be distinguished from the closely apposed ensheathing cells RLID00037634 RLGI00915 E13 mRNA Rattus norvegicus 9724458 Axon Olfactory In situ hybridization We had previous evidence that between E13 and E19 CGRP mRNA was present at the level of olfactory axons but the resolution of light-microscope in situ hybridization did not permit the axons to be distinguished from the closely apposed ensheathing cells RLID00037635 RLGI00916 DPH4 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037636 RLGI00917 DHFR mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037637 RLGI00918 DECTIN-1 mRNA Mus musculus 11491532 Dendrite Dendritic cell - The DECTIN-1 gene is highly expressed at the mRNA level in dendritic cells and is not further up-regulated during the maturation of these cells with tumor necrosis factor-alpha. RLID00037638 RLGI00919 cy-tRNA Phe tRNA Plasmodium falciparum 25391660 Cytoplasm - Northern blot "We also show that cytoplasmic tRNA Cys and tRNA Phe are imported into the P. falciparum mitochondria, implying that the parasite mitochondria probably import charged tRNAs from the cytoplasmic pool. Likewise, cy-tRNA Phe in charged (cy-Phe-tRNA Phe ) and uncharged forms was found in both cytoplasmic and organelle partitions (Figure 4E). This suggests the import of cy-Phe-tRNA Phe into the parasite mitochondria (Figure 4E). " RLID00037639 RLGI00920 cy-tRNA Phe tRNA Plasmodium falciparum 25391660 Mitochondrion - Northern blot "We also show that cytoplasmic tRNA Cys and tRNA Phe are imported into the P. falciparum mitochondria, implying that the parasite mitochondria probably import charged tRNAs from the cytoplasmic pool. Likewise, cy-tRNA Phe in charged (cy-Phe-tRNA Phe ) and uncharged forms was found in both cytoplasmic and organelle partitions (Figure 4E). This suggests the import of cy-Phe-tRNA Phe into the parasite mitochondria (Figure 4E). " RLID00037640 RLGI00921 cy-tRNA Cys tRNA Plasmodium falciparum 25391660 Cytoplasm - Northern blot "We also show that cytoplasmic tRNA Cys and tRNA Phe are imported into the P. falciparum mitochondria, implying that the parasite mitochondria probably import charged tRNAs from the cytoplasmic pool. Our data show that cy-tRNA Cys was evident in both cellular and organelle RNA fractions, suggesting its presence in both cytoplasm and mitochondria (Figure 4B). " RLID00037641 RLGI00922 cy-tRNA Cys tRNA Plasmodium falciparum 25391660 Mitochondrion - Northern blot "We also show that cytoplasmic tRNA Cys and tRNA Phe are imported into the P. falciparum mitochondria, implying that the parasite mitochondria probably import charged tRNAs from the cytoplasmic pool. Our data show that cy-tRNA Cys was evident in both cellular and organelle RNA fractions, suggesting its presence in both cytoplasm and mitochondria (Figure 4B). " RLID00037642 RLGI00923 Cytochrome p450 mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00037643 RLGI00924 CYP8B1 mRNA Chlorocebus sabaeus 23271194 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "Note that only ALPP, and not CYP8B1 mRNA, is maintained on the ER after ribosomes are disassembled with puromycin or HHT (Figures 2-3).ote that only ALPP, and not CYP8B1 mRNA, is maintained on the ER after ribosomes are disassembled with puromycin or HHT (Figures 2-3). " RLID00037644 RLGI00925 CYP8B1 mRNA Chlorocebus sabaeus 23271194 Cytoplasm COS-7 cell Fluorescence in situ hybridization "Our data clearly shows that for both ALPP and CYP8B1, about 60% of the cytoplasmic mRNA is associated with the ER. Since both of these mRNAs encode proteins that are processed in the ER-lumen, our results are consistent with the idea that such mRNAs are translated on the surface of the ER. " RLID00037645 RLGI00928 CS mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037646 RLGI00929 cry mRNA Nicotiana tabacum 7632920 Cytoplasm Protoplast Northern blot We provide evidence that this low cytoplasmic cry IA(b) mRNA level is not due to a rapid turnover but rather results from a marginal import flow of cry messenger into the cytoplasm. RLID00037647 RLGI00930 Cox I mRNA Mus musculus 25847616 Mitochondrion Liver Next-generation sequencing|qRT-PCR "MtDNA encoded Cox I, an RNA known to be localized within the mitochondrial matrix, served as a positive control. " RLID00037648 RLGI00931 Copia 837/947 mRNA Drosophila melanogaster 17923096 Nucleus Embryo In situ hybridization Table S6: Correlations in mRNA patterns and protein function/localization. Data are collected from Table S6. RLID00037649 RLGI00932 Clytia Poc1 mRNA Clytia hemisphaerica 21098654 Perinuclear Gonads In situ hybridization "Within the oocyte, Poc1 mRNA appeared concentrated in a patchy distribution around the nucleus (=germinal vesicle). " RLID00037650 RLGI00933 CLCK3 mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00037651 RLGI00934 CKCS2 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037652 RLGI00935 Ci-PEM1 mRNA Ascidian 15923652 Cell cortex Embryo In situ hybridization "The fluorescent signal for Ci-PEM1 RNAs colocalizes with this vegetal cER network (Fig. 2IIC1,C2) as described for Halocynthia (Sardet et al., 2003). " RLID00037653 RLGI00936 C-I 30 mRNA Drosophila melanogaster 25565208 Mitochondrion HEK293T Fluorescence in situ hybridization "Mito localization of mammalian C-I 30 mRNA was further confirmed using the MS2-GFP/MS2-bs tagging system (Bertrand et al., 1998) (Fig. S2B, C). " RLID00037654 RLGI00937 chr6.trna61-MetCAT tRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00037655 RLGI00938 chr5.trna5-ValAAC tRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00037656 RLGI00939 chr5.trna11-LysCTT tRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00037657 RLGI00940 chr17.trna28-CysGCA tRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00037658 RLGI00941 chr17.trna10-GlyTCC tRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00037659 RLGI00942 chr16.trna10-LysCTT tRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00037660 RLGI00943 chr13.trna3-GluTTC tRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00037661 RLGI00944 chr1.trna54-GluCTC tRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00037662 RLGI00945 chr1.trna33-GlyGCC tRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00037663 RLGI00946 chr1.trna124-GlyCCC tRNA Homo sapiens 24205503 Exosome HeLa cell Next-generation sequencing Table 1: RNA representation in exosomes versus parental HeLa cells: top 10 RNA transcripts organized by RNA type. Values for cells and exosome preparations represent mean counts of mapped reads to reference transcripts from three replicate cell lysates. Accession numbers and gene symbols were obtained from NCBI RefSeq annotation. Data are collected from Table 1. RLID00037664 RLGI00947 Cde2-related kinase mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray|Northern blot "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00037665 RLGI00948 CDCH mRNA Lymnaea stagnalis 1431053 Lysosome Neuropeptidergic cell In situ hybridization "As was the case for the 28s rRNA sequences, CDCH mRNA was also found to be present in lysosomal structures. Gold label was also observed in the nucleus, mostly associated with heterochromatin, and some of these particles were localized in the vicinity of the nuclear membrane. " RLID00037666 RLGI00948 CDCH mRNA Lymnaea stagnalis 1431053 Nucleus Neuropeptidergic cell In situ hybridization "Figure 2. Detection of CDCH mRNA in (a) a Lowicryl section and (b) an ultra-thin cryosection with digoxigenin-labeled 18-mer CDCH oligonucleotide. Most of the gold labels are associated with RER. M, mitochondrion; R, rough endoplasmic reticulum; N. nucleus. Bars = 0.5pm. Data are collected from Figure 2. " RLID00037667 RLGI00948 CDCH mRNA Lymnaea stagnalis 1431053 Endoplasmic reticulum Neuropeptidergic cell In situ hybridization "Figure 2. Detection of CDCH mRNA in (a) a Lowicryl section and (b) an ultra-thin cryosection with digoxigenin-labeled 18-mer CDCH oligonucleotide. Most of the gold labels are associated with RER. M, mitochondrion; R, rough endoplasmic reticulum; N. nucleus. Bars = 0.5pm. Data are collected from Figure 2. " RLID00037668 RLGI00948 CDCH mRNA Lymnaea stagnalis 1431053 Mitochondrion Neuropeptidergic cell In situ hybridization "Figure 2. Detection of CDCH mRNA in (a) a Lowicryl section and (b) an ultra-thin cryosection with digoxigenin-labeled 18-mer CDCH oligonucleotide. Most of the gold labels are associated with RER. M, mitochondrion; R, rough endoplasmic reticulum; N. nucleus. Bars = 0.5pm. Data are collected from Figure 2. " RLID00037669 RLGI00948 CDCH mRNA Lymnaea stagnalis 8353303 Axon Neuron In situ hybridization "Gold labeling was observed in secretion granules, and double labeling experiments showed that these granules also contain CDCH. This specific intragranular localization suggest that CDCH mRNA is transported through the axon and released by exocytosis in the haemolymph. " RLID00037670 RLGI00953 CCM2 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037671 RLGI00954 CCDC2 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037672 RLGI00955 CaMKII-alpha mRNA Rattus norvegicus 12121312 Dendrite Hippocampus In situ hybridization "Nonstimulated rats: BDNF, TrkB, and CaMKII-beta mRNAs localized in the soma and in the proximal dendrites of hippocampal pyramidal cells, and in the soma only of dentate gyrus (DG) granule cells; CaMKII-a mRNA localized throughout the dendritic length in neurons of all hippocampal subfields. In contrast, CaMKII-beta (Figs. 1C and 2D), BDNF (Figs. 1E and 2G), and TrkB mRNAs (Figs.1G and 2J) were localized in the soma and in the proximal dendrites of hippocampal pyramidal cells, and in the soma only of DG granule cells. " RLID00037673 RLGI00956 CaMKII-beta mRNA Rattus norvegicus 12121312 Dendrite Hippocampus In situ hybridization "Pilocarpine seizures: increased staining levels of CaMKII-alpha mRNA throughout the whole dendritic length in all hippocampal subfields; induction of CaMKII-beta, BDNF, and TrkB mRNAs dendritic targeting in CA1, CA3, and DG neurons. Data provide evidence that BDNF, TrkB, and CaMKII-beta and -alpha mRNAs are accumulated in the dendrites of specific hippocampal neurons during pilocarpine seizures and kindling development. " RLID00037674 RLGI00957 CaM I mRNA Rattus norvegicus 8833091 Dendrite Brain In situ hybridization "In cerebral cortical neurons, the 4.0-kb CaM I mRNA was detected in apical dendrites at postnatal day (PD) 5 to 15. Our results demonstrate that the 4.0-kb CaM I transcript is localized to apical dendrites of neurons during postnatal development of the rat brain. Figure 4 illustrates the localization of the 4.0-kb CaM I mRNA in apical dendrites of pyramidal cortical neurons at PD 5 (Cx) and PD 15 (Cx, arrowheads). " RLID00037675 RLGI00958 calreticulin (CRT) mRNA Petunia hybrida 14564059 Endoplasmic reticulum Pollen tube In situ hybridization "The mRNA transcripts of the CRT gene were localized mainly on the surface of endoplasmic reticulum (ER) membranes, both in transmitting cells and in the tip cytoplasm of pollen tubes. " RLID00037676 RLGI00958 calreticulin (CRT) mRNA Petunia hybrida 14564059 Cytoplasm Pollen tube In situ hybridization "The mRNA transcripts of the CRT gene were localized mainly on the surface of endoplasmic reticulum (ER) membranes, both in transmitting cells and in the tip cytoplasm of pollen tubes. " RLID00037677 RLGI00960 calreticulin (CRT) mRNA Hyacinthus orientalis 26354004 Endoplasmic reticulum Embryo Fluorescence in situ hybridization "CRT mRNA and the protein localize mainly to the endoplasmic reticulum (ER) and Golgi compartments of the cells, which are involved in sexual reproduction events, such as those in sister synergids, the egg cell, the central cell, zygote and the developing endosperm. " RLID00037678 RLGI00960 calreticulin (CRT) mRNA Hyacinthus orientalis 26354004 Golgi apparatus Embryo Fluorescence in situ hybridization "CRT mRNA and the protein localize mainly to the endoplasmic reticulum (ER) and Golgi compartments of the cells, which are involved in sexual reproduction events, such as those in sister synergids, the egg cell, the central cell, zygote and the developing endosperm. " RLID00037679 RLGI00960 calreticulin (CRT) mRNA Hyacinthus orientalis 26354004 Cytoplasm Embryo Fluorescence in situ hybridization "The presence of CRT transcripts was still localized predominantly in the cytoplasm of investigated cells (Fig. 1e-g); however, few fluorescent spots were also observed around or within their nuclei (Fig. 1e, f, arrows) and nucleoli (Fig. 1e, f, arrowheads). " RLID00037680 RLGI00960 calreticulin (CRT) mRNA Hyacinthus orientalis 26354004 Nucleus Embryo Fluorescence in situ hybridization "The presence of CRT transcripts was still localized predominantly in the cytoplasm of investigated cells (Fig. 1e-g); however, few fluorescent spots were also observed around or within their nuclei (Fig. 1e, f, arrows) and nucleoli (Fig. 1e, f, arrowheads). " RLID00037681 RLGI00960 calreticulin (CRT) mRNA Hyacinthus orientalis 26354004 Nucleolus Embryo Fluorescence in situ hybridization "The presence of CRT transcripts was still localized predominantly in the cytoplasm of investigated cells (Fig. 1e-g); however, few fluorescent spots were also observed around or within their nuclei (Fig. 1e, f, arrows) and nucleoli (Fig. 1e, f, arrowheads). " RLID00037682 RLGI00965 CagDazl mRNA Carassius auratus gibelio 19504540 Germ plasm Oocyte In situ hybridization "In addition, in situ hybridization and immunofluorescence localization demonstrated its specific expression in germ cells, and both its transcript and protein were localized to germ plasm. Then, co-localization of CagDazl and mitochondrial cloud was found, confirming that CagDazl transcript and its protein are germ plasm component and move via METRO pathway during oogenesis. " RLID00037683 RLGI00965 CagDazl mRNA Carassius auratus gibelio 19504540 Mitochondrion Oocyte In situ hybridization "In addition, in situ hybridization and immunofluorescence localization demonstrated its specific expression in germ cells, and both its transcript and protein were localized to germ plasm. Then, co-localization of CagDazl and mitochondrial cloud was found, confirming that CagDazl transcript and its protein are germ plasm component and move via METRO pathway during oogenesis. " RLID00037684 RLGI00967 C5T1 lncRNA Homo sapiens 26673966 Nucleus Huh7 cell qRT-PCR We also found the identified transcripts (C5T1lncRNA) to be highly enriched in the nucleus in contrast to their neighbouring coding C5 gene (Figure 2b). RLID00037685 RLGI00968 C10/XFACS mRNA Xenopus laevis 11784096 Germ plasm Oocyte In situ hybridization "The germ plasm is a specialized region of oocyte cytoplasm that contains determinants of germ cell fate. In Xenopus oocytes, the germ plasm is a part of the METRO region of mitochondrial cloud. It contains the germinal granules and a variety of coding and noncoding RNAs that include Xcat2, Xlsirts, Xdazl, DEADSouth, Xpat, Xwnt11, fatVg, B7/Fingers, C10/XFACS, and mitochondrial large and small rRNA. We analyzed the distribution of these 11 different RNAs within the various compartments of germ plasm during Xenopus oogenesis and development by using whole-mount electron microscopy in situ hybridization. " RLID00037686 RLGI00969 b-tubulin mRNA Rattus norvegicus 9322162 Dendrite Neuron In situ hybridization "The mRNAs for b-tubulin, neurofilament 68, and F1/GAP43 were restricted to the region of the cell body and very proximal dendrites in most neurons. " RLID00037687 RLGI00969 b-tubulin mRNA Rattus norvegicus 9322162 Cell body Neuron In situ hybridization "The mRNAs for b-tubulin, neurofilament 68, and F1/GAP43 were restricted to the region of the cell body and very proximal dendrites in most neurons. " RLID00037688 RLGI00971 btsz-2poly mRNA Drosophila melanogaster 14581614 Apical Follicle cell In situ hybridization "When we examined btsz-2poly and btsz-2myc mRNA expression in follicle cells, we found that transcripts localized to the follicle cell apical plasma membrane in a manner indistinguishable from an untagged btsz-2 construct. " RLID00037689 RLGI00972 btsz-2myc mRNA Drosophila melanogaster 14581614 Apical Follicle cell In situ hybridization "When we examined btsz-2poly and btsz-2myc mRNA expression in follicle cells, we found that transcripts localized to the follicle cell apical plasma membrane in a manner indistinguishable from an untagged btsz-2 construct. " RLID00037690 RLGI00973 bt884 mRNA Nicotiana tabacum 7632920 Cytoplasm Protoplast Northern blot "Based on a steady state level of about one transcript per cell, the nucleo-cytoplasmic flow rate of bt884 mRNA should be less than 1 transcript per 10h. " RLID00037691 RLGI00973 bt884 mRNA Nicotiana tabacum 7632920 Nucleus Protoplast Northern blot "Based on a steady state level of about one transcript per cell, the nucleo-cytoplasmic flow rate of bt884 mRNA should be less than 1 transcript per 10h. " RLID00037692 RLGI00975 box C/D snoRNA Rattus norvegicus 25792744 Cytoplasm Myocardium Next-generation sequencing|qRT-PCR "RNA-sequencing analysis reveals that box C/D snoRNAs as a class are present in the cytoplasm, where their levels are dynamically regulated by NADPH oxidase. " RLID00037693 RLGI00976 beta-F1-ATPase mRNA Rattus norvegicus 9065777 Cytoplasm Hepatocytes Electron microscopy|ISH "In contrast, beta-F1-ATPase mRNA appears in rounded electron-dense clusters, often in close proximity to mitochondria. " RLID00037694 RLGI00977 bed mRNA Drosophila melanogaster 8895662 Anterior Embryo In situ hybridization Bed mRNA is tightly localized to the anterior pole of the prospective embryo during oogenesis such that none is detectable elsewhere in the egg. RLID00037695 RLGI00978 BC1 mRNA Bos taurus 12654521 Dendrite NG108-15 cell Luciferase assay "BC1 RNA is localized to dendritic domains as ribonucleoprotein particles, and it has been suggested to play a functional role in translational regulation of dendritic mRNAs. " RLID00037696 RLGI00979 B7/Fingers mRNA Xenopus laevis 11784096 Germ plasm Oocyte In situ hybridization "The germ plasm is a specialized region of oocyte cytoplasm that contains determinants of germ cell fate. In Xenopus oocytes, the germ plasm is a part of the METRO region of mitochondrial cloud. It contains the germinal granules and a variety of coding and noncoding RNAs that include Xcat2, Xlsirts, Xdazl, DEADSouth, Xpat, Xwnt11, fatVg, B7/Fingers, C10/XFACS, and mitochondrial large and small rRNA. We analyzed the distribution of these 11 different RNAs within the various compartments of germ plasm during Xenopus oogenesis and development by using whole-mount electron microscopy in situ hybridization. " RLID00037697 RLGI00980 ATP5p mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037698 RLGI00981 ATP5m mRNA Solanum tuberosum 20506035 Cytosol Potato tuber qRT-PCR Table 1: Function and mitochondrial association of 17 cytosolic mRNAs. Data are collected from Table 1. RLID00037699 RLGI00982 ATP synthase mRNA Rattus norvegicus 17785519 Axon Dorsal root ganglia qRT-PCR Axonal mRNA levels for each of the 50 transcripts were determined using axonal RNA isolates for reverse transcription followed by quantitative PCR (qPCR). The qPCR results are detailed in Table I. These data show both ligand and transcript specificity for the regulation of axonal mRNA levels. RLID00037700 RLGI00983 AteIF4E mRNA Arabidopsis thaliana 17662723 Chloroplast Seedling In situ hybridization|RT-PCR "The disappearance of the exogenously added cpSRP43 protein and AteIF4E RNA after protease and RNase action, whereas the LseIF4E mRNA was still detectable, strongly suggests that it is located inside the chloroplast envelope. " RLID00037701 RLGI00984 AT03385 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037702 RLGI00985 AT02159 mRNA Drosophila melanogaster 25838129 Nucleus Nurse cell In situ hybridization Data come from DOT (Dresden Ovary Table) database: http://tomancak-srv1.mpi-cbg.de/DOT/main.html RLID00037703 RLGI00986 Asp-GAC tRNA Homo sapiens 25135963 Exosome Serum Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037704 RLGI00986 Asp-GAC tRNA Homo sapiens 25135963 Exosome Urine Next-generation sequencing "When summarizing total counts per sample type, we calculated mean raw counts per RNA-Seq library and then ranked them from high to low for miRNA, mRNA, ncRNA and tRNA categories. The top 12 are listed in table 1. Data are collected from Table 1: RNA representation in serum- and urine-derived exosomes: top 12 RNA transcripts organized by RNA type. Values represent mean counts of mapped reads to reference transcripts. " RLID00037705 RLGI00988 aPKC mRNA Ascidian 16569661 Cytoplasm Embryo Northern blot The aPKC mRNA is equally present in all cell lineages and is distributed ubiquitously throughout the cytoplasm of all blastomeres. RLID00037706 RLGI00989 ANFR-C mRNA Rattus norvegicus 8745272 Cytoplasm Pituitary gland In situ hybridization "Atrial Natriuretic Factor (ANF) action is mediated by highly selective and specific receptors. Three subtypes have been characterized and cloned: ANF receptor-A, -B and -C. These subtypes are all expressed in the anterior pituitary of the rat. In the present study, the mRNA for each subtype was detected by in situ hybridization. The amounts of ANFR-A and -B mRNA were found to be similar, and to be twice that of ANFR-C mRNA. At the ultrastructural level, the three types of ANFR mRNA were expressed in three anterior pituitary cell types, namely lactotrophs, corticotrophs, and gonadotrophs, identified by their hormonal content. No signal was revealed in somatotrophs or thyrotrophs. The different forms of mRNA were similar in terms of subcellular localization: in the cytoplasmic matrix and the nuclear euchromatin. These data indicate that the anterior pituitary is an important target tissue for ANF action. " RLID00037707 RLGI00989 ANFR-C mRNA Rattus norvegicus 8745272 Nucleus Pituitary gland In situ hybridization "Atrial Natriuretic Factor (ANF) action is mediated by highly selective and specific receptors. Three subtypes have been characterized and cloned: ANF receptor-A, -B and -C. These subtypes are all expressed in the anterior pituitary of the rat. In the present study, the mRNA for each subtype was detected by in situ hybridization. The amounts of ANFR-A and -B mRNA were found to be similar, and to be twice that of ANFR-C mRNA. At the ultrastructural level, the three types of ANFR mRNA were expressed in three anterior pituitary cell types, namely lactotrophs, corticotrophs, and gonadotrophs, identified by their hormonal content. No signal was revealed in somatotrophs or thyrotrophs. The different forms of mRNA were similar in terms of subcellular localization: in the cytoplasmic matrix and the nuclear euchromatin. These data indicate that the anterior pituitary is an important target tissue for ANF action. " RLID00037708 RLGI00991 ANFR-B mRNA Rattus norvegicus 8745272 Cytoplasm Pituitary gland In situ hybridization "Atrial Natriuretic Factor (ANF) action is mediated by highly selective and specific receptors. Three subtypes have been characterized and cloned: ANF receptor-A, -B and -C. These subtypes are all expressed in the anterior pituitary of the rat. In the present study, the mRNA for each subtype was detected by in situ hybridization. The amounts of ANFR-A and -B mRNA were found to be similar, and to be twice that of ANFR-C mRNA. At the ultrastructural level, the three types of ANFR mRNA were expressed in three anterior pituitary cell types, namely lactotrophs, corticotrophs, and gonadotrophs, identified by their hormonal content. No signal was revealed in somatotrophs or thyrotrophs. The different forms of mRNA were similar in terms of subcellular localization: in the cytoplasmic matrix and the nuclear euchromatin. These data indicate that the anterior pituitary is an important target tissue for ANF action. " RLID00037709 RLGI00991 ANFR-B mRNA Rattus norvegicus 8745272 Nucleus Pituitary gland In situ hybridization "Atrial Natriuretic Factor (ANF) action is mediated by highly selective and specific receptors. Three subtypes have been characterized and cloned: ANF receptor-A, -B and -C. These subtypes are all expressed in the anterior pituitary of the rat. In the present study, the mRNA for each subtype was detected by in situ hybridization. The amounts of ANFR-A and -B mRNA were found to be similar, and to be twice that of ANFR-C mRNA. At the ultrastructural level, the three types of ANFR mRNA were expressed in three anterior pituitary cell types, namely lactotrophs, corticotrophs, and gonadotrophs, identified by their hormonal content. No signal was revealed in somatotrophs or thyrotrophs. The different forms of mRNA were similar in terms of subcellular localization: in the cytoplasmic matrix and the nuclear euchromatin. These data indicate that the anterior pituitary is an important target tissue for ANF action. " RLID00037710 RLGI00993 ANFR-A mRNA Rattus norvegicus 8745272 Cytoplasm Pituitary gland In situ hybridization "Atrial Natriuretic Factor (ANF) action is mediated by highly selective and specific receptors. Three subtypes have been characterized and cloned: ANF receptor-A, -B and -C. These subtypes are all expressed in the anterior pituitary of the rat. In the present study, the mRNA for each subtype was detected by in situ hybridization. The amounts of ANFR-A and -B mRNA were found to be similar, and to be twice that of ANFR-C mRNA. At the ultrastructural level, the three types of ANFR mRNA were expressed in three anterior pituitary cell types, namely lactotrophs, corticotrophs, and gonadotrophs, identified by their hormonal content. No signal was revealed in somatotrophs or thyrotrophs. The different forms of mRNA were similar in terms of subcellular localization: in the cytoplasmic matrix and the nuclear euchromatin. These data indicate that the anterior pituitary is an important target tissue for ANF action. " RLID00037711 RLGI00993 ANFR-A mRNA Rattus norvegicus 8745272 Nucleus Pituitary gland In situ hybridization "Atrial Natriuretic Factor (ANF) action is mediated by highly selective and specific receptors. Three subtypes have been characterized and cloned: ANF receptor-A, -B and -C. These subtypes are all expressed in the anterior pituitary of the rat. In the present study, the mRNA for each subtype was detected by in situ hybridization. The amounts of ANFR-A and -B mRNA were found to be similar, and to be twice that of ANFR-C mRNA. At the ultrastructural level, the three types of ANFR mRNA were expressed in three anterior pituitary cell types, namely lactotrophs, corticotrophs, and gonadotrophs, identified by their hormonal content. No signal was revealed in somatotrophs or thyrotrophs. The different forms of mRNA were similar in terms of subcellular localization: in the cytoplasmic matrix and the nuclear euchromatin. These data indicate that the anterior pituitary is an important target tissue for ANF action. " RLID00037712 RLGI00995 ALPP mRNA Chlorocebus sabaeus 23271194 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "Note that only ALPP, and not CYP8B1 mRNA, is maintained on the ER after ribosomes are disassembled with puromycin or HHT (Figures 2-3).ote that only ALPP, and not CYP8B1 mRNA, is maintained on the ER after ribosomes are disassembled with puromycin or HHT (Figures 2-3). " RLID00037713 RLGI00995 ALPP mRNA Chlorocebus sabaeus 23271194 Cytoplasm COS-7 cell Fluorescence in situ hybridization "Our data clearly shows that for both ALPP and CYP8B1, about 60% of the cytoplasmic mRNA is associated with the ER. Since both of these mRNAs encode proteins that are processed in the ER-lumen, our results are consistent with the idea that such mRNAs are translated on the surface of the ER. " RLID00037714 RLGI00997 alpha-F1-ATPase mRNA Rattus norvegicus 9065777 Cytoplasm Hepatocytes Electron microscopy|ISH Alpha-F1-ATPase mRNA is dispersed and scattered in the cytoplasm. RLID00037715 RLGI00998 AKR7A5 mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037716 RLGI00999 AF2 mRNA Homo sapiens 24019514 Endoplasmic reticulum COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmids containing either ALPP, t-ftz, or the AF1, AF2 fusion constructs and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (Ctrl), puromycin (Puro), or HHT for 30 min and then extracted with either digitonin alone, or for puromycin-treated cells, with 20 mM EDTA. The cells were then fixed, stained for mRNA using specific FISH probes (ALPP probe for AF1, ftz probe for AF2), and imaged. FIGURE 2B: quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 2. " RLID00037717 RLGI00999 AF2 mRNA Homo sapiens 24019514 Nucleus COS-7 cell Fluorescence in situ hybridization "COS-7 cells were transfected with plasmids containing either ALPP, t-ftz, or the AF1, AF2 fusion constructs and allowed to express mRNA for 18-24 h. The cells were then treated with DMSO (Ctrl), puromycin (Puro), or HHT for 30 min and then extracted with either digitonin alone, or for puromycin-treated cells, with 20 mM EDTA. The cells were then fixed, stained for mRNA using specific FISH probes (ALPP probe for AF1, ftz probe for AF2), and imaged. FIGURE 2B: quantification of the fluorescence intensities of mRNA in the ER and nucleus. Data are collected from Figure 2. " RLID00037718 RLGI01001 ADORA2BP mRNA Canis lupus familiaris 18845542 Pseudopodium MSV-MDCK-INV cell Microarray "A cohort of 242 identified genes enriched 1.6-fold in the pseudopodial fraction is listed in Table 1 and functionally grouped. The number of genes/group is presented as a pie chart (Fig. 4B). Of particular interest is the abundance of proteins involved in signaling and protein translation. Indeed, a large number of pseudopod-enriched mRNAs encode ribosomal proteins (Table 1). TABLE 1: mRNAs enriched 1.6-fold in the pseudopodial fraction relative to cell body. Data are collected from Table 1. " RLID00037719 RLGI01002 7SL lncRNA Mus musculus 26464439 Axon Motoneuron In situ hybridization|qRT-PCR "In contrast, 7SL RNA was enriched in the axonal compared to the somatodendritic cytoplasm. Importantly, 7SL was readily detectable in motor axons which is in line with our whole transcriptome profiling data. " RLID00037720 RLGI01003 7SK snRNA Rattus norvegicus 25792744 Nucleus Myocardium qRT-PCR "For both cytosolic isolation methods, immunoblotting showed enrichment of cytosolic proteins and depletion of nuclear/nucleolar proteins in cytosolic fractions, whereas qPCR demonstrated that the small ncRNAs 7SK and U6 were predominantly in the nuclear fraction (Fig. 1, E-H). " RLID00037721 RLGI01004 75S mRNA Chironomus 148971 Cytoplasm Salivary gland cell Electrophoretic analysis "After a pulse of RNA precursor to the living animal, labeled Balbiani ring 75S RNA is found mainly in the cytoplasm located closer to the nuclear envelope, with smaller amounts toward the periphery of the cell. nuclear envelope, with smaller amounts toward the periphery of the cell. Thus the 75S RNA located closer to the nuclear envelope is the most recently exported 75S RNA. " RLID00037722 RLGI01005 5S rRNA rRNA Saccharomyces cerevisiae 20691904 Mitochondrion Yeast RT-PCR "Figure 4: PNPASE Augments RNase P, 5S rRNA, and MRP RNA Import into Yeast Mitochondria. Data are collected from Figur 4. " RLID00037723 RLGI01006 28S rRNA Lymnaea stagnalis 1431053 Nucleolus Neuropeptidergic cell In situ hybridization "Figure 3. Detection of 28s rRNA in an ultra-thin cryosection with a digoxigenin- labeled plasmid probe, showing dense labeling of a nucleolus. N, nucleus; n=nucleolus. Bar = 0.5vm. Data are collected from Figure 3. " RLID00037724 RLGI01006 28S rRNA Lymnaea stagnalis 1431053 Lysosome Neuropeptidergic cell In situ hybridization "Figure 4. Influence of fixation on the detection of 28s rRNA in ultra-thin cryosections of CDCs with a digoxigenin-labeled 28s oligonucleotide probe. (a) Localization of gold label in a lysosomal structure in addition to gold label associated with RER when tissue was fixed in 1% formaldehyde, 0.Wo glutaraldehyde. (b) Lysosomes were devoid of gold label after hybridization on formaldehyde-fixed tissue. L, lysosome; R, rough endoplasmic reticulum; N, nucleus. Bars = 0.5pm. Data are collected from Figure 4. " RLID00037725 RLGI01009 26S RNA mRNA Gallus gallus 837448 Ribosome Fibroblast Radioactive labeling "Here we show that during infection, the 26s RNA is found mainly in membrane-bound polysomes which synthesize all three virion structural proteins. " RLID00037726 RLGI01010 18S rRNA Petunia hybrida 25732863 Cytoplasm Pollen tube Fluorescence in situ hybridization "As germination proceeded, 18S rRNA preferentially accumulated in the cytoplasm of the outgrowing pollen tube (Fig. 4b). " RLID00037727 RLGI01010 18S rRNA Petunia hybrida 25732863 Ribosome Pollen tube Fluorescence in situ hybridization "The above results led us to propose that the common sites of PhCRT mRNA, CRT, and 18S rRNA localization in germinating pollen and growing pollen tubes are enriched in ER membrane-bound ribosomes. Together, our results show that the regions in which PhCRT mRNA, CRT protein, and 18S rRNA are localized are also rich in RER. " RLID00037728 RLGI01010 18S rRNA Petunia hybrida 25732863 Endoplasmic reticulum Pollen tube Fluorescence in situ hybridization "The above results led us to propose that the common sites of PhCRT mRNA, CRT, and 18S rRNA localization in germinating pollen and growing pollen tubes are enriched in ER membrane-bound ribosomes. Together, our results show that the regions in which PhCRT mRNA, CRT protein, and 18S rRNA are localized are also rich in RER. " RLID00037729 RLGI01013 18S rRNA Beta vulgaris 8718677 Cytoplasm Pachytene meiocytes In situ hybridization "Both RNA-RNA and DNA-RNA hybridizations in sections of sugar beet anthers resulted in a very specific localization of 18 S rRNA fragments. Light microscopic observations showed that the most intense hybridization signal was visualized in the nucleoli, and less conspicuous labeling could be seen in the cytoplasm. Some labeling was also found in the nucleoplasm, whereas vacuoles and cell walls were clearly devoid of silverdeposits (Fig. 2A,B). " RLID00037730 RLGI01013 18S rRNA Beta vulgaris 8718677 Nucleolus Pachytene meiocytes In situ hybridization "Both RNA-RNA and DNA-RNA hybridizations in sections of sugar beet anthers resulted in a very specific localization of 18 S rRNA fragments. Light microscopic observations showed that the most intense hybridization signal was visualized in the nucleoli, and less conspicuous labeling could be seen in the cytoplasm. Some labeling was also found in the nucleoplasm, whereas vacuoles and cell walls were clearly devoid of silverdeposits (Fig. 2A,B). " RLID00037731 RLGI01013 18S rRNA Beta vulgaris 8718677 Nucleoplasm Pachytene meiocytes In situ hybridization "Both RNA-RNA and DNA-RNA hybridizations in sections of sugar beet anthers resulted in a very specific localization of 18 S rRNA fragments. Light microscopic observations showed that the most intense hybridization signal was visualized in the nucleoli, and less conspicuous labeling could be seen in the cytoplasm. Some labeling was also found in the nucleoplasm, whereas vacuoles and cell walls were clearly devoid of silverdeposits (Fig. 2A,B). " RLID00037732 RLGI01016 16S rRNA Homo sapiens 21854988 Mitochondrion 143B cell Next-generation sequencing "Table S2, Relating to Figure 2, (Sheet A) Expression of annotated mRNA, tRNA and rRNA in 143B cells whole mitochondria and mitoplast preparations determined by RNA sequencing (reads per million per kb), and expression levels relative to total mitochondrial gene expression, and ratio of sense/antisense transcription relative to each gene indicated. Data are collected from Figure 2. " RLID00037733 RLGI01017 12S rRNA Homo sapiens 21854988 Mitochondrion 143B cell Next-generation sequencing "Table S2, Relating to Figure 2, (Sheet A) Expression of annotated mRNA, tRNA and rRNA in 143B cells whole mitochondria and mitoplast preparations determined by RNA sequencing (reads per million per kb), and expression levels relative to total mitochondrial gene expression, and ratio of sense/antisense transcription relative to each gene indicated. Data are collected from Figure 2. " RLID00037734 RLGI01018 lincRNA-EC2 lncRNA Mus musculus 24200680 Nucleus Liver erythroid cell qRT-PCR We focus on 12 such candidates and find that they are nuclear-localized and exhibit complex developmental expression patterns. Data are collected from Figure 6. RLID00037735 RLGI01019 lincRNA-EC4 lncRNA Mus musculus 24200680 Nucleus Liver erythroid cell qRT-PCR We focus on 12 such candidates and find that they are nuclear-localized and exhibit complex developmental expression patterns. Data are collected from Figure 6. RLID00037736 RLGI01020 lincRNA-EC5 lncRNA Mus musculus 24200680 Nucleus Liver erythroid cell qRT-PCR We focus on 12 such candidates and find that they are nuclear-localized and exhibit complex developmental expression patterns. Data are collected from Figure 6. RLID00037737 RLGI01021 lincRNA-EC8 lncRNA Mus musculus 24200680 Nucleus Liver erythroid cell qRT-PCR We focus on 12 such candidates and find that they are nuclear-localized and exhibit complex developmental expression patterns. Data are collected from Figure 6. RLID00037738 RLGI01022 lincRNA-EC9 lncRNA Mus musculus 24200680 Nucleus Liver erythroid cell qRT-PCR We focus on 12 such candidates and find that they are nuclear-localized and exhibit complex developmental expression patterns. Data are collected from Figure 6. RLID00037739 RLGI01023 lncCyt b lncRNA Homo sapiens 22028365 Mitochondrion HeLa cell qRT-PCR|RNA-seq|Northern blot "The regions of the mitochondrial genome complementary to the genes that encode ND5, ND6, and Cyt b mRNAs were found to have high levels of lncRNAs (Fig. 1B). " RLID00037740 RLGI01024 lncND5 lncRNA Homo sapiens 22028365 Mitochondrion HeLa cell qRT-PCR|RNA-seq|Northern blot "The regions of the mitochondrial genome complementary to the genes that encode ND5, ND6, and Cyt b mRNAs were found to have high levels of lncRNAs (Fig. 1B). " RLID00037741 RLGI01025 lncND6 lncRNA Homo sapiens 22028365 Mitochondrion HeLa cell qRT-PCR|RNA-seq|Northern blot "The regions of the mitochondrial genome complementary to the genes that encode ND5, ND6, and Cyt b mRNAs were found to have high levels of lncRNAs (Fig. 1B). " RLID00037742 RLGI01026 lncRNA-LALR1 lncRNA Mus musculus 23483581 Cytoplasm Liver In situ hybridization The transcript of lncRNA-LALR1 was mainly located in the nucleus and cytoplasm of hepatocytes and was up-regulated at 18 hours after surgery. RLID00037743 RLGI01027 lncRNA-hLALR1 lncRNA Homo sapiens 23483581 Nucleus Liver In situ hybridization The transcript of lncRNA-LALR1 was mainly located in the nucleus and cytoplasm of hepatocytes and was up-regulated at 18 hours after surgery. RLID00037744 RLGI01028 lncRNA-LALR1 lncRNA Mus musculus 23483581 Nucleus Liver In situ hybridization The transcript of lncRNA-LALR1 was mainly located in the nucleus and cytoplasm of hepatocytes and was up-regulated at 18 hours after surgery. RLID00037745 RLGI01030 CLCK3 mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00037746 RLGI01031 Cde2-related kinase mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00037747 RLGI01032 hSNF2a mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00037748 RLGI01033 Heme synthetase mRNA Homo sapiens 12923260 Ribosome Jurkat cell Microarray "TABLE 2.Enrichment of mRNAs in free and ER-bound polysomes. Stratagene 1.2K human cDNA microarrays were screened with probes developed against either the total RNA pool or the ER-membrane-enriched RNA pool of Jurkat cells. Representative gene products enriched in the ER polysome fraction, free polysome fraction, or distributed between both pools are provided. For the latter, candidate gene products were selected on the basis of their noncanonical distribution on the ER-membrane-bound polysomes. The data are collected from Table 2. " RLID00037749 RLGI01034 pair-rule mRNA Drosophila melanogaster 15852043 Apical Embryo - "The best-characterized example is the PAIR-RULE mRNAs, which localize to the apical cytoplasm above the nuclei of D. melanogaster syncytial blastoderm embryos (FIG. 1c) " RLID00037750 RLGI01035 PpCSD1 mRNA Physcomitrella patens 23749811 Chloroplast Protonemata RT-PCR "To examine the effect of copper deficiency on expression of CuZn-SOD genes, reverse transcription PCR (RT-PCR) was performed after culture for 30 d (Fig. 3). Copper deficiency resulted in the repression of two chloroplastic CuZn-SOD genes (PpCSD1 and PpCSD2), but did not affect the expression of two cytosolic CuZn-SOD genes (PpCSD3 and PpCSD4). Expression of the extracellular and chloroplastic Fe-SOD genes (PpFSD1 and PpFSD2) and the mitochondrial Mn-SOD gene (PpMSD) was unaffected by copper deficiency. Because the cytosolic PpFSD3 showed a degenerated gene structure, it seemed likely to be a pseudogene. However, its expression was strongly induced by copper deficiency. This observation will be discussed, along with the copper responsive cis-element, in the Discussion. " RLID00037751 RLGI01036 PpCSD2 mRNA Physcomitrella patens 23749811 Chloroplast Protonemata RT-PCR "To examine the effect of copper deficiency on expression of CuZn-SOD genes, reverse transcription PCR (RT-PCR) was performed after culture for 30 d (Fig. 3). Copper deficiency resulted in the repression of two chloroplastic CuZn-SOD genes (PpCSD1 and PpCSD2), but did not affect the expression of two cytosolic CuZn-SOD genes (PpCSD3 and PpCSD4). Expression of the extracellular and chloroplastic Fe-SOD genes (PpFSD1 and PpFSD2) and the mitochondrial Mn-SOD gene (PpMSD) was unaffected by copper deficiency. Because the cytosolic PpFSD3 showed a degenerated gene structure, it seemed likely to be a pseudogene. However, its expression was strongly induced by copper deficiency. This observation will be discussed, along with the copper responsive cis-element, in the Discussion. " RLID00037752 RLGI01037 PpCSD3 mRNA Physcomitrella patens 23749811 Cytosol Protonemata RT-PCR "To examine the effect of copper deficiency on expression of CuZn-SOD genes, reverse transcription PCR (RT-PCR) was performed after culture for 30 d (Fig. 3). Copper deficiency resulted in the repression of two chloroplastic CuZn-SOD genes (PpCSD1 and PpCSD2), but did not affect the expression of two cytosolic CuZn-SOD genes (PpCSD3 and PpCSD4). Expression of the extracellular and chloroplastic Fe-SOD genes (PpFSD1 and PpFSD2) and the mitochondrial Mn-SOD gene (PpMSD) was unaffected by copper deficiency. Because the cytosolic PpFSD3 showed a degenerated gene structure, it seemed likely to be a pseudogene. However, its expression was strongly induced by copper deficiency. This observation will be discussed, along with the copper responsive cis-element, in the Discussion. " RLID00037753 RLGI01038 PpCSD4 mRNA Physcomitrella patens 23749811 Cytosol Protonemata RT-PCR "To examine the effect of copper deficiency on expression of CuZn-SOD genes, reverse transcription PCR (RT-PCR) was performed after culture for 30 d (Fig. 3). Copper deficiency resulted in the repression of two chloroplastic CuZn-SOD genes (PpCSD1 and PpCSD2), but did not affect the expression of two cytosolic CuZn-SOD genes (PpCSD3 and PpCSD4). Expression of the extracellular and chloroplastic Fe-SOD genes (PpFSD1 and PpFSD2) and the mitochondrial Mn-SOD gene (PpMSD) was unaffected by copper deficiency. Because the cytosolic PpFSD3 showed a degenerated gene structure, it seemed likely to be a pseudogene. However, its expression was strongly induced by copper deficiency. This observation will be discussed, along with the copper responsive cis-element, in the Discussion. " RLID00037754 RLGI01039 PpFSD2 mRNA Physcomitrella patens 23749811 Chloroplast Protonemata RT-PCR "To examine the effect of copper deficiency on expression of CuZn-SOD genes, reverse transcription PCR (RT-PCR) was performed after culture for 30 d (Fig. 3). Copper deficiency resulted in the repression of two chloroplastic CuZn-SOD genes (PpCSD1 and PpCSD2), but did not affect the expression of two cytosolic CuZn-SOD genes (PpCSD3 and PpCSD4). Expression of the extracellular and chloroplastic Fe-SOD genes (PpFSD1 and PpFSD2) and the mitochondrial Mn-SOD gene (PpMSD) was unaffected by copper deficiency. Because the cytosolic PpFSD3 showed a degenerated gene structure, it seemed likely to be a pseudogene. However, its expression was strongly induced by copper deficiency. This observation will be discussed, along with the copper responsive cis-element, in the Discussion. " RLID00037755 RLGI01040 PpMSD mRNA Physcomitrella patens 23749811 Mitochondrion Protonemata RT-PCR "To examine the effect of copper deficiency on expression of CuZn-SOD genes, reverse transcription PCR (RT-PCR) was performed after culture for 30 d (Fig. 3). Copper deficiency resulted in the repression of two chloroplastic CuZn-SOD genes (PpCSD1 and PpCSD2), but did not affect the expression of two cytosolic CuZn-SOD genes (PpCSD3 and PpCSD4). Expression of the extracellular and chloroplastic Fe-SOD genes (PpFSD1 and PpFSD2) and the mitochondrial Mn-SOD gene (PpMSD) was unaffected by copper deficiency. Because the cytosolic PpFSD3 showed a degenerated gene structure, it seemed likely to be a pseudogene. However, its expression was strongly induced by copper deficiency. This observation will be discussed, along with the copper responsive cis-element, in the Discussion. " RLID00037756 RLGI01041 Cox2 Divergent lncRNA Mus musculus 23898399 Nucleus 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00037757 RLGI01041 Cox2 Divergent lncRNA Mus musculus 23898399 Cytoplasm 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00037758 RLGI01042 Gp96 Convergent lncRNA Mus musculus 23898399 Nucleus 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00037759 RLGI01042 Gp96 Convergent lncRNA Mus musculus 23898399 Cytoplasm 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00037760 RLGI01043 H2-T23/24AS lncRNA Mus musculus 23898399 Nucleus 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00037761 RLGI01043 H2-T23/24AS lncRNA Mus musculus 23898399 Cytoplasm 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00037762 RLGI01044 Pbrm1 Convergent lncRNA Mus musculus 23898399 Nucleus 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00037763 RLGI01045 "Scripture 16,612 " lncRNA Mus musculus 23898399 Nucleus 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00037764 RLGI01046 "Scripture 60,588 " lncRNA Mus musculus 23898399 Nucleus 293T cell qRT-PCR "Gapdh was tested as a control and found to be evenly distributed between the nucleus and cytoplasm with little transcript found on the chromatin. Likewise, Cox2 Divergent, Gp96 Convergent, and H2-T23/24AS were evenly distributed between nucleus and cytoplasm. HoxA11AS was mostly nuclear with some transcript found in the cytoplasm, but not on the chromatin. Interestingly, Lethe, Pbrm1 Convergent, Scripture 16,612 and Scripture 60,588 were found mostly on the chromatin, with a smaller fraction in the nucleus. " RLID00037765 U58494 U58494 http://www.ncbi.nlm.nih.gov/nuccore/U58494 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00037766 U58671 U58671 http://www.ncbi.nlm.nih.gov/nuccore/U58671 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00037767 X15624 X15624 http://www.ncbi.nlm.nih.gov/nuccore/X15624 lncRNA Homo sapiens 23663360 Exosome Plasma Next-generation sequencing "To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences). " RLID00037768 X53630 X53630 http://www.ncbi.nlm.nih.gov/nuccore/X53630 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00037769 X57780 X57780 http://www.ncbi.nlm.nih.gov/nuccore/X57780 mRNA Mus musculus 22406755 Nucleus Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00037770 X96606 X96606 http://www.ncbi.nlm.nih.gov/nuccore/X96606 mRNA Mus musculus 17486113 Exosome Mast cell Microarray "The identified mRNA in exosomes was approximately 8% of the mRNA detected in the donor cells (16,000 mRNA; Fig. 3a-d; see Supplementary Information, Table S2, and see Accession numbers in Methods). Data are collected from Table S2. " RLID00037771 Y14821 Y14821 http://www.ncbi.nlm.nih.gov/nuccore/Y14821 lncRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00037772 Y14822 Y14822 http://www.ncbi.nlm.nih.gov/nuccore/Y14822 mRNA Mus musculus 22406755 Cytoplasm Neuroblastoma cell Microarray "Array analysis revealed 499 lncRNAs that were significantly enriched in the cytoplasm and 191 in the nucleus. Intersection with lincRNAs and lncRNAs listed in lncRNAdb revealed a number of known and uncharacterized localizations of lncRNAs, including nuclear enrichment of Adapt33, Zfas1, and several other snoRNA host genes. Taken together, these results support the widespread trafficking of lncRNAs to different subcellular locations. All normalized stability and localization array data is available in Supplemental S2. " RLID00037773 10984 KCNQ1OT1 http://www.ncbi.nlm.nih.gov/gene/?term=10984 "KCNQ1-AS2, KCNQ10T1, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012" lncRNA Homo sapiens 17917697 Nucleus NHFs(normal human fibroblast cell lines) FISH "We next performed RNA/DNA FISH on normal human lymphoblasts (NHF) and normal human fibroblasts (NHF, NHF2, NTI-4, TIG-1-20) to confirm the physiological state of LIT1 RNA in human cells. LIT1 RNA signals were observed in almost all interphase nuclei of the lymphoblast cell line (97% of interphase nuclei) and of four fibroblast cell lines." RLID00037774 10984 KCNQ1OT1 http://www.ncbi.nlm.nih.gov/gene/?term=10984 "KCNQ1-AS2, KCNQ10T1, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012" lncRNA Homo sapiens 17917697 Nucleus CHO11P-8(Chinese hamster ovary hybrid cells) FISH The RNA/DNA FISH shows that the LIT1 RNA signal co-localized with DNA in these CHO hybrid interphase nuclei. We detected a single LIT1 RNA signal in the nuclei of CHO11P-8 hybrid cells. RLID00037775 100038448 Gm10840 http://www.ncbi.nlm.nih.gov/gene/?term=100038448 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037776 100042484 4732419C18Rik http://www.ncbi.nlm.nih.gov/gene/?term=100042484 Gm3866 lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037777 100043309 4732414G09Rik http://www.ncbi.nlm.nih.gov/gene/?term=100043309 lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037778 100043902 Six3os1 http://www.ncbi.nlm.nih.gov/gene/?term=100043902 "Rncr1, Six3os, D17Mgi26, E130112H22Rik" lncRNA Mus musculus 18184812 Cytoplasm Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. The possibility that these intronic ncRNAs are solely a consequence of persevering nonfunctional lariats is unlikely because we also observe (i) intronic ncRNAs expressed in the cytoplasm, (ii) nonexpressed intronic ncRNAs of highly expressed host protein-coding genes, and (iii) intronic ncRNAs that exhibit a discordant expression profile to their host protein-coding gene." RLID00037779 100503924 Fcor http://www.ncbi.nlm.nih.gov/gene/?term=100503924 2400009B08Rik mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037780 100504593 Gm13431 http://www.ncbi.nlm.nih.gov/gene/?term=100504593 lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037781 100526471 Mir3069 http://www.ncbi.nlm.nih.gov/gene/?term=100526471 "mir-3069, mmu-mir-3069" miRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037782 100579148 Gm17409 http://www.ncbi.nlm.nih.gov/gene/?term=100579148 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037783 102640635 Gm26615 http://www.ncbi.nlm.nih.gov/gene/?term=102640635 lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037784 103012 Firre http://www.ncbi.nlm.nih.gov/gene/?term=103012 "AW048145, 5830467J12Rik, 6720401G13Rik" lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037785 140795 P2ry14 http://www.ncbi.nlm.nih.gov/gene/?term=140795 "A330108O13Rik, Gpr105, P2Y14" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037786 15405 Hoxa9 http://www.ncbi.nlm.nih.gov/gene/?term=15405 "D6a9, Hox-1.7" mRNA Mus musculus 18184812 Cytoplasm Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. The possibility that these intronic ncRNAs are solely a consequence of persevering nonfunctional lariats is unlikely because we also observe (i) intronic ncRNAs expressed in the cytoplasm, (ii) nonexpressed intronic ncRNAs of highly expressed host protein-coding genes, and (iii) intronic ncRNAs that exhibit a discordant expression profile to their host protein-coding gene." RLID00037787 16201 Ilf3 http://www.ncbi.nlm.nih.gov/gene/?term=16201 "MBII-26, MPHOSPH4, NF90, NFAR" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037788 17263 Meg3 http://www.ncbi.nlm.nih.gov/gene/?term=17263 "Gtl2, R74756, R75394, AI425946, AW108224, D12Bwg1266e, 2900016C05Rik, 3110050O07Rik, 6330408G06Rik" lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037789 17755 Map1b http://www.ncbi.nlm.nih.gov/gene/?term=17755 "A230055D22, AI843217, LC1, MAP5, Mtap-5, Mtap1b, Mtap5" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037790 18484 Pam http://www.ncbi.nlm.nih.gov/gene/?term=18484 PHM mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037791 19085 Prkar1b http://www.ncbi.nlm.nih.gov/gene/?term=19085 "AI385716, RIbeta" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037792 19091 Prkg1 http://www.ncbi.nlm.nih.gov/gene/?term=19091 "AW125416, CGKI, Gm19690b, Prkgr1b, Prkg1" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037793 20238 Atxn1 http://www.ncbi.nlm.nih.gov/gene/?term=20238 "2900016G23Rik, Atx1, C85907, Gm10786, Sca1" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037794 207278 Fchsd2 http://www.ncbi.nlm.nih.gov/gene/?term=207278 "BC034086, R74866, Sh3md3, mKIAA0769" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037795 208941 Gm4755 http://www.ncbi.nlm.nih.gov/gene/?term=208941 F730043H23 lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037796 210274 Shank2 http://www.ncbi.nlm.nih.gov/gene/?term=210274 "ProSAP1, mKIAA1022" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037797 210933 Adgrb3 http://www.ncbi.nlm.nih.gov/gene/?term=210933 "A830096D10Rik, Bai3" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037798 211712 Pcdh9 http://www.ncbi.nlm.nih.gov/gene/?term=211712 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037799 228012 Tlk1 http://www.ncbi.nlm.nih.gov/gene/?term=228012 4930545J15Rik mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037800 238161 Akap6 http://www.ncbi.nlm.nih.gov/gene/?term=238161 "AI482140, Akapalpha, Akapbeta, PRKA" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037801 23965 Tenm3 http://www.ncbi.nlm.nih.gov/gene/?term=23965 "2610100B16Rik, Odz1, Odz3, Ten-m3, mKIAA1455" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037802 268723 A830039N20Rik http://www.ncbi.nlm.nih.gov/gene/?term=268723 lncRNA Mus musculus 18184812 Cytoplasm Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. The possibility that these intronic ncRNAs are solely a consequence of persevering nonfunctional lariats is unlikely because we also observe (i) intronic ncRNAs expressed in the cytoplasm, (ii) nonexpressed intronic ncRNAs of highly expressed host protein-coding genes, and (iii) intronic ncRNAs that exhibit a discordant expression profile to their host protein-coding gene." RLID00037803 268755 Mir124a-1hg http://www.ncbi.nlm.nih.gov/gene/?term=268755 "Rncr3, mir-3078, mir-124-1, A930011O12Rik" lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037804 268906 LOC268906 http://www.ncbi.nlm.nih.gov/gene/?term=268906 mRNA Mus musculus 18184812 Cytoplasm Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. The possibility that these intronic ncRNAs are solely a consequence of persevering nonfunctional lariats is unlikely because we also observe (i) intronic ncRNAs expressed in the cytoplasm, (ii) nonexpressed intronic ncRNAs of highly expressed host protein-coding genes, and (iii) intronic ncRNAs that exhibit a discordant expression profile to their host protein-coding gene." RLID00037805 30046 Zfp292 http://www.ncbi.nlm.nih.gov/gene/?term=30046 "5730450D02Rik, 5830493J20Rik, 9430062L07Rik, AI449016, Krox-10, Zfp-15, Zfp15, Zn-15, Zn-16, mKIAA0530" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037806 319622 Itpripl2 http://www.ncbi.nlm.nih.gov/gene/?term=319622 "C130081G24, E030018N11Rik" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037807 319982 5930430L01Rik http://www.ncbi.nlm.nih.gov/gene/?term=319982 lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037808 320019 Ptgs2os http://www.ncbi.nlm.nih.gov/gene/?term=320019 7530420F21Rik lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037809 320138 A130050O07Rik http://www.ncbi.nlm.nih.gov/gene/?term=320138 unknown Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037810 320800 9230112E08Rik http://www.ncbi.nlm.nih.gov/gene/?term=320800 lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037811 329562 A530013C23Rik http://www.ncbi.nlm.nih.gov/gene/?term=329562 lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037812 330173 2610524H06Rik http://www.ncbi.nlm.nih.gov/gene/?term=330173 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037813 330183 Gm16063 http://www.ncbi.nlm.nih.gov/gene/?term=330183 G630008E18 lncRNA Mus musculus 18184812 Cytoplasm Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. The possibility that these intronic ncRNAs are solely a consequence of persevering nonfunctional lariats is unlikely because we also observe (i) intronic ncRNAs expressed in the cytoplasm, (ii) nonexpressed intronic ncRNAs of highly expressed host protein-coding genes, and (iii) intronic ncRNAs that exhibit a discordant expression profile to their host protein-coding gene." RLID00037814 384569 Nova2 http://www.ncbi.nlm.nih.gov/gene/?term=384569 Gm1424 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037815 433485 Syndig1 http://www.ncbi.nlm.nih.gov/gene/?term=433485 "AW123113, DSPC2, Gm14134, H2C20orf39, Tmem90b" mRNA Mus musculus 18184812 Cytoplasm Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. The possibility that these intronic ncRNAs are solely a consequence of persevering nonfunctional lariats is unlikely because we also observe (i) intronic ncRNAs expressed in the cytoplasm, (ii) nonexpressed intronic ncRNAs of highly expressed host protein-coding genes, and (iii) intronic ncRNAs that exhibit a discordant expression profile to their host protein-coding gene." RLID00037816 433966 5730422E09Rik http://www.ncbi.nlm.nih.gov/gene/?term=433966 lncRNA Mus musculus 18184812 Cytoplasm Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. The possibility that these intronic ncRNAs are solely a consequence of persevering nonfunctional lariats is unlikely because we also observe (i) intronic ncRNAs expressed in the cytoplasm, (ii) nonexpressed intronic ncRNAs of highly expressed host protein-coding genes, and (iii) intronic ncRNAs that exhibit a discordant expression profile to their host protein-coding gene." RLID00037817 434008 Tmem178b http://www.ncbi.nlm.nih.gov/gene/?term=434008 "EG434008, Gm5567" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037818 434353 A330074K22Rik http://www.ncbi.nlm.nih.gov/gene/?term=434353 lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037819 50505 Ercc4 http://www.ncbi.nlm.nih.gov/gene/?term=50505 "AI606920, Xpf" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037820 50794 Klf13 http://www.ncbi.nlm.nih.gov/gene/?term=50794 "0610043C13Rik, 9430029L20Rik, Bteb3, FKLF-2, FKLF2, NSLP1, RFLAT-1, RFLAT1" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037821 52480 Snhg14 http://www.ncbi.nlm.nih.gov/gene/?term=52480 "Lncat, Pwcr1, Gm42386, Gm42387, Gm42388, Gm42389, Gm42390, Gm42391, Gm45921, AU018661, Ube3a-ATS, D7Ertd715e, U-Ube3a-ATS, lincRNA-EC50, C230091D08Rik" lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037822 544874 LOC544874 http://www.ncbi.nlm.nih.gov/gene/?term=544874 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037823 625175 1700028E10Rik http://www.ncbi.nlm.nih.gov/gene/?term=625175 "Gm6561, A630054D14" lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037824 63830 Kcnq1ot1 http://www.ncbi.nlm.nih.gov/gene/?term=63830 "Lit1, Tssc8, Kvlqt1-as" lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037825 66602 1700020I14Rik http://www.ncbi.nlm.nih.gov/gene/?term=66602 "Cyrano, AI451541, AI585852, AW538376, AW558897, 1190006L01Rik, 4933437I03Rik" lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037826 66662 Fbxl12os http://www.ncbi.nlm.nih.gov/gene/?term=66662 5730577I03Rik lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037827 68127 B230217C12Rik http://www.ncbi.nlm.nih.gov/gene/?term=68127 AI840637 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037828 68434 1010001N08Rik http://www.ncbi.nlm.nih.gov/gene/?term=68434 Gata6as lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037829 69077 Psmd11 http://www.ncbi.nlm.nih.gov/gene/?term=69077 "1700089D09Rik, 1810019E17Rik, 2610024G20Rik, 2810055C24Rik, C78232, P44.5, S9" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037830 69865 A1cf http://www.ncbi.nlm.nih.gov/gene/?term=69865 "1810073H04Rik, ACF64, ACF65, ASP, Acf, MCM, MerCreMer, Tg(Myh6-cre/Esr1*)1Jmk, mer" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037831 69953 2810025M15Rik http://www.ncbi.nlm.nih.gov/gene/?term=69953 AI429618 lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037832 71373 Prr16 http://www.ncbi.nlm.nih.gov/gene/?term=71373 "5430406M13Rik, AI607429" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037833 73941 4930412L05Rik http://www.ncbi.nlm.nih.gov/gene/?term=73941 LeXis lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037834 74184 2310065F04Rik http://www.ncbi.nlm.nih.gov/gene/?term=74184 linc-Myh lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037835 75745 Rian http://www.ncbi.nlm.nih.gov/gene/?term=75745 "Meg8, 5530401N18Rik, C130089L09Rik" lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037836 76100 5830454E08Rik http://www.ncbi.nlm.nih.gov/gene/?term=76100 lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037837 76626 Msi2 http://www.ncbi.nlm.nih.gov/gene/?term=76626 "1700105C15Rik, AI451722, AI563628, AW489193h, Msi2" mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037838 77866 E130102H24Rik http://www.ncbi.nlm.nih.gov/gene/?term=77866 lncRNA Mus musculus 18184812 Cytoplasm Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. The possibility that these intronic ncRNAs are solely a consequence of persevering nonfunctional lariats is unlikely because we also observe (i) intronic ncRNAs expressed in the cytoplasm, (ii) nonexpressed intronic ncRNAs of highly expressed host protein-coding genes, and (iii) intronic ncRNAs that exhibit a discordant expression profile to their host protein-coding gene." RLID00037839 AK018559 AK018559 https://www.ncbi.nlm.nih.gov/nuccore/AK018559 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037840 AK032777 AK032777 https://www.ncbi.nlm.nih.gov/nuccore/AK032777 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037841 AK033161 AK033161 https://www.ncbi.nlm.nih.gov/nuccore/AK033161 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037842 AK033985 AK033985 https://www.ncbi.nlm.nih.gov/nuccore/AK033985 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037843 AK035692 AK035692 https://www.ncbi.nlm.nih.gov/nuccore/AK035692 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037844 AK038224 AK038224 https://www.ncbi.nlm.nih.gov/nuccore/AK038224 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037845 AK039341 AK039341 https://www.ncbi.nlm.nih.gov/nuccore/AK039341 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037846 AK039686 AK039686 https://www.ncbi.nlm.nih.gov/nuccore/AK039686 mRNA Mus musculus 18184812 Cytoplasm Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. The possibility that these intronic ncRNAs are solely a consequence of persevering nonfunctional lariats is unlikely because we also observe (i) intronic ncRNAs expressed in the cytoplasm, (ii) nonexpressed intronic ncRNAs of highly expressed host protein-coding genes, and (iii) intronic ncRNAs that exhibit a discordant expression profile to their host protein-coding gene." RLID00037847 AK046764 AK046764 https://www.ncbi.nlm.nih.gov/nuccore/AK046764 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037848 AK046779 AK046779 https://www.ncbi.nlm.nih.gov/nuccore/AK046779 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037849 AK052663 AK052663 https://www.ncbi.nlm.nih.gov/nuccore/AK052663 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037850 AK053343 AK053343 https://www.ncbi.nlm.nih.gov/nuccore/AK053343 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037851 AK076684 AK076684 https://www.ncbi.nlm.nih.gov/nuccore/AK076684 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037852 AK078603 AK078603 https://www.ncbi.nlm.nih.gov/nuccore/AK078603 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037853 AK082015 AK082015 https://www.ncbi.nlm.nih.gov/nuccore/AK082015 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037854 BE649186 BE649186 https://www.ncbi.nlm.nih.gov/nuccore/BE649186 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037855 DV657041 DV657041 https://www.ncbi.nlm.nih.gov/nuccore/DV657041 mRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. We used previously characterized ncRNAs and mRNAs with known subcellular expression profiles as crude markers of subcellular compartments. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037856 ENSMUSG00000087615 Pnpla1os http://www.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000087615 Gm16190 lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037857 ENSMUSG00000093385 A330044P14Rik http://www.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000093385 lncRNA Mus musculus 18184812 Nucleus Cerebellar Purkinje cell ISH "Using in situ hybridization data from the Allen Brain Atlas, we identified 849 ncRNAs (of 1,328 examined) that are expressed in the adult mouse brain and found that the majority were associated with specific neuroanatomical regions, cell types, or subcellular compartments. Data were collected from supplemental meterial SI Table 1. From the 88 (10% of expressed ncRNAs) that were expressed in Purkinje cells, 25 (29%) showed a nuclear restricted expression profile, a further 54 (61%) appeared as foci or speckles, and the remaining 9 (10%) were diffusely expressed throughout the soma." RLID00037858 101101691 Hm629797 http://www.ncbi.nlm.nih.gov/gene/?term=101101691 Mrhl lncRNA Mus musculus 18515546 Nucleus Testis and liver RT-PCR "The nuclear localization of mrhl RNA was not surprising, as many noncoding RNAs have been shown earlier to exhibit definite nuclear-localization patterns mediating potent regulatory events such as regulation of coding genes (CTN), imprinting (H19, Air), and dosage compensation (Xist, roX)." RLID00037859 66961 Neat1 http://www.ncbi.nlm.nih.gov/gene/?term=66961 "VINC, 2310043N10Rik" lncRNA Mus musculus 19106332 Nucleus C2C12 RNA-FISH The Men ¦Å/¦Â (also known as Neat1) transcripts are localized to nuclear paraspeckles and directly interact with NONO. RLID00037860 55384 MEG3 http://www.ncbi.nlm.nih.gov/gene/?term=55384 "FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1" lncRNA Homo sapiens 20404130 Nucleus Fibroblast cells qPCR "Interestingly, we have identified two intergenic CARs in the DLK1-DIO3-imprinted domain; one of them overlaps with the maternally expressed ncRNA MEG3, indicating that, like Kcnq1ot1 and Airn ncRNAs, MEG3 may play a role in regulation of imprinting of flanking genes in the DLK1-DIO3 domain. We also investigated the subcellular localization of the validated CARs and found that all transcripts except one were clearly localized to the nuclear compartment, which is in agreement with the chromatin-associated functions of these transcripts." RLID00037861 10178876 yar http://www.ncbi.nlm.nih.gov/gene/?term=10178876 anon-1Be; CR42744; Dmel\CR42744 lncRNA Drosophila melanogaster 21775470 Cytoplasm Embryos RNA-FISH "The function of lncRNAs depends upon their subcellular location. As lncRNAs can localize to the nucleus and cytoplasm, we determined which subcellular compartment contains yar. Finally, these data imply that spliced yar RNAs are cytoplasmic, a conclusion that is supported by analyses of Ras64B RNA." RLID00037862 100129387 GABPB1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100129387 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037863 100505881 MAGI2-AS3 http://www.ncbi.nlm.nih.gov/gene/?term=100505881 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037864 100506965 PWAR6 http://www.ncbi.nlm.nih.gov/gene/?term=100506965 "HBT8, PAR-6" lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037865 11336 EXOC3 http://www.ncbi.nlm.nih.gov/gene/?term=11336 "SEC6, SEC6L1, Sec6p" mRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We excluded the 23,241 clusters that were predicted to be protein-coding mRNAs, and also removed the 4,888 clusters for which the gene locus was covered by sequence information available only from the RefSeq or the Ensembl, or by just one 5¡ä-EST. Ultimately, we obtained 3,180 clusters as candidates likely to encode ncRNAs. Data were collected from supplemental meterial Table S2. we defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5¨C2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Among the 29 candidates, 25 were localized in the nucleus Data were collected from supplemental meterial Table S4." RLID00037866 148189 LINC00662 http://www.ncbi.nlm.nih.gov/gene/?term=148189 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037867 148189 LINC00662 http://www.ncbi.nlm.nih.gov/gene/?term=148189 lncRNA Homo sapiens 22532836 Cytoplasm HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037868 157627 LINC00599 http://www.ncbi.nlm.nih.gov/gene/?term=157627 Rncr3 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037869 267017 HLA-Z http://www.ncbi.nlm.nih.gov/gene/?term=267017 HLA-Z1 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037870 267017 HLA-Z http://www.ncbi.nlm.nih.gov/gene/?term=267017 HLA-Z1 lncRNA Homo sapiens 22532836 Cytoplasm HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037871 339290 LINC00667 http://www.ncbi.nlm.nih.gov/gene/?term=339290 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037872 375035 SFT2D2 http://www.ncbi.nlm.nih.gov/gene/?term=375035 "UNQ512, dJ747L4.C1.2" mRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We excluded the 23,241 clusters that were predicted to be protein-coding mRNAs, and also removed the 4,888 clusters for which the gene locus was covered by sequence information available only from the RefSeq or the Ensembl, or by just one 5¡ä-EST. Ultimately, we obtained 3,180 clusters as candidates likely to encode ncRNAs. Data were collected from supplemental meterial Table S2. we defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5¨C2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Among the 29 candidates, 25 were localized in the nucleus Data were collected from supplemental meterial Table S4." RLID00037873 378805 LINC-PINT http://www.ncbi.nlm.nih.gov/gene/?term=378805 "LincRNA-Pint, MKLN1-AS1, PINT" lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037874 4026 LPP http://www.ncbi.nlm.nih.gov/gene/?term=4026 mRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We excluded the 23,241 clusters that were predicted to be protein-coding mRNAs, and also removed the 4,888 clusters for which the gene locus was covered by sequence information available only from the RefSeq or the Ensembl, or by just one 5¡ä-EST. Ultimately, we obtained 3,180 clusters as candidates likely to encode ncRNAs. Data were collected from supplemental meterial Table S2. we defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5¨C2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Among the 29 candidates, 25 were localized in the nucleus Data were collected from supplemental meterial Table S4." RLID00037875 414777 HCG18 http://www.ncbi.nlm.nih.gov/gene/?term=414777 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037876 4719 NDUFS1 http://www.ncbi.nlm.nih.gov/gene/?term=4719 CI-75k; CI-75Kd; PRO1304 mRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We excluded the 23,241 clusters that were predicted to be protein-coding mRNAs, and also removed the 4,888 clusters for which the gene locus was covered by sequence information available only from the RefSeq or the Ensembl, or by just one 5¡ä-EST. Ultimately, we obtained 3,180 clusters as candidates likely to encode ncRNAs. Data were collected from supplemental meterial Table S2. we defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5¨C2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Among the 29 candidates, 25 were localized in the nucleus Data were collected from supplemental meterial Table S4." RLID00037877 492311 IGIP http://www.ncbi.nlm.nih.gov/gene/?term=492311 C5orf53 mRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We excluded the 23,241 clusters that were predicted to be protein-coding mRNAs, and also removed the 4,888 clusters for which the gene locus was covered by sequence information available only from the RefSeq or the Ensembl, or by just one 5¡ä-EST. Ultimately, we obtained 3,180 clusters as candidates likely to encode ncRNAs. Data were collected from supplemental meterial Table S2. we defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5¨C2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Among the 29 candidates, 25 were localized in the nucleus Data were collected from supplemental meterial Table S4." RLID00037878 55449 DHRS4-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=55449 "AS1DHRS4, C14orf167, C14orf67, DHRS4AS1, PRO1488" lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037879 55449 DHRS4-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=55449 "AS1DHRS4, C14orf167, C14orf67, DHRS4AS1, PRO1488" lncRNA Homo sapiens 22532836 Cytoplasm HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037880 55819 RNF130 http://www.ncbi.nlm.nih.gov/gene/?term=55819 "G1RZFP, GOLIATH, GP" mRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We excluded the 23,241 clusters that were predicted to be protein-coding mRNAs, and also removed the 4,888 clusters for which the gene locus was covered by sequence information available only from the RefSeq or the Ensembl, or by just one 5¡ä-EST. Ultimately, we obtained 3,180 clusters as candidates likely to encode ncRNAs. Data were collected from supplemental meterial Table S2. we defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5¨C2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Among the 29 candidates, 25 were localized in the nucleus Data were collected from supplemental meterial Table S4." RLID00037881 644873 LINC01184 http://www.ncbi.nlm.nih.gov/gene/?term=644873 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037882 7273 TTN http://www.ncbi.nlm.nih.gov/gene/?term=7273 "CMD1G, CMH9, CMPD4, EOMFC, HMERF, LGMD2J, MYLK5, SALMY, TMD" mRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We excluded the 23,241 clusters that were predicted to be protein-coding mRNAs, and also removed the 4,888 clusters for which the gene locus was covered by sequence information available only from the RefSeq or the Ensembl, or by just one 5¡ä-EST. Ultimately, we obtained 3,180 clusters as candidates likely to encode ncRNAs. Data were collected from supplemental meterial Table S2. we defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5¨C2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Among the 29 candidates, 25 were localized in the nucleus Data were collected from supplemental meterial Table S4." RLID00037883 729082 OIP5-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=729082 "cyrano, linc-OIP5" lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037884 729678 LINC00847 http://www.ncbi.nlm.nih.gov/gene/?term=729678 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037885 729678 LINC00847 http://www.ncbi.nlm.nih.gov/gene/?term=729678 lncRNA Homo sapiens 22532836 Cytoplasm HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037886 84281 C2orf88 http://www.ncbi.nlm.nih.gov/gene/?term=84281 smAKAP mRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We excluded the 23,241 clusters that were predicted to be protein-coding mRNAs, and also removed the 4,888 clusters for which the gene locus was covered by sequence information available only from the RefSeq or the Ensembl, or by just one 5¡ä-EST. Ultimately, we obtained 3,180 clusters as candidates likely to encode ncRNAs. Data were collected from supplemental meterial Table S2. we defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5¨C2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Among the 29 candidates, 25 were localized in the nucleus Data were collected from supplemental meterial Table S4." RLID00037887 84981 MIR22HG http://www.ncbi.nlm.nih.gov/gene/?term=84981 C17orf91 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037888 ENSG00000174093 RP11-1407O15.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000174093 mRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We excluded the 23,241 clusters that were predicted to be protein-coding mRNAs, and also removed the 4,888 clusters for which the gene locus was covered by sequence information available only from the RefSeq or the Ensembl, or by just one 5¡ä-EST. Ultimately, we obtained 3,180 clusters as candidates likely to encode ncRNAs. Data were collected from supplemental meterial Table S2. we defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5¨C2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Among the 29 candidates, 25 were localized in the nucleus Data were collected from supplemental meterial Table S4." RLID00037889 ENSG00000216775 RP1-152L7.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000216775 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037890 ENSG00000223745 RP4-717I23.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000223745 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037891 ENSG00000233137 RP11-220I1.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000233137 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037892 ENSG00000259976 RP11-553L6.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259976 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037893 ENSG00000268205 CTC-444N24.11 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000268205 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037894 ENSG00000272761 RP11-572C15.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272761 lncRNA Homo sapiens 22532836 Nucleus HeLa cells qRT-PCR "We identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Data can be seen from Table 1. We defined the subcellular localization of the transcripts as: N/C ratio >2, nuclear localization; N/C ratio 0.5-2, nuclear and cytoplasmic localization; and N/C ratio <0.5, cytoplasmic localization. Data were collected from supplemental meterial Table S4." RLID00037895 50652 PCA3 http://www.ncbi.nlm.nih.gov/gene/?term=50652 "DD3, NCRNA00019, PCAT3" lncRNA Homo sapiens 23130941 Nucleus Prostate cancer cell lines qRT-PCR We determined the cell compartment localization of PCA3 in LNCaP cells by differential centrifugation and qRT-PCR. Our data showed that PCA3 expression was mainly restricted to the nuclear and microsomal compartments of LNCaP cells. RLID00037896 37820 PPP1R15 http://www.ncbi.nlm.nih.gov/gene/?term=37820 "Dmel_CG3825, CG3825, Dm-GADD34, Dmel\CG3825, GADD34, Gadd34, dGADD34, dPPP1R15, gadd34" mRNA Drosophila melanogaster 23135994 Endoplasmic Reticulum Drosophila S2 cells RT-PCR "The vast majority of mRNAs that were strongly associated with the ER were degraded faster during ER stress in an Ire1-dependent manner, suggesting that RIDD is the default pathway for ER-localized mRNAs during stress.Data were collected from supplemental meterials." RLID00037897 41983 Manf http://www.ncbi.nlm.nih.gov/gene/?term=41983 "Dmel_CG7013, ARP-like, CG7013, DmMANF, DmManf, Dmel\CG7013, MANF, anon-EST:ParkEST188" mRNA Drosophila melanogaster 23135994 Endoplasmic Reticulum Drosophila S2 cells RT-PCR "The vast majority of mRNAs that were strongly associated with the ER were degraded faster during ER stress in an Ire2-dependent manner, suggesting that RIDD is the default pathway for ER-localized mRNAs during stress.Data were collected from supplemental meterials." RLID00037898 43832 PlexA http://www.ncbi.nlm.nih.gov/gene/?term=43832 "Dmel_CG11081, BcDNA:GM05237, CG11081, D-Plex A, DPlexA, Dmel\CG11081, Plex11, lincRNA.927, plex, plex A, plexA, PlexA" mRNA Drosophila melanogaster 23135994 Endoplasmic Reticulum Drosophila S2 cells RT-PCR "The vast majority of mRNAs that were strongly associated with the ER were degraded faster during ER stress in an Ire3-dependent manner, suggesting that RIDD is the default pathway for ER-localized mRNAs during stress.Data were collected from supplemental meterials." RLID00037899 100289178 GNG12-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100289178 lncRNA Homo sapiens 23871723 Nucleus HB2 cells RT-qPCR We also investigated the cellular localization of GNG12-AS1 and found that it is predominantly present in the nucleus. RLID00037900 103012 Firre http://www.ncbi.nlm.nih.gov/gene/?term=103012 "AW048145, 5830467J12Rik, 6720401G13Rik" lncRNA Mus musculus 24463464 Nucleus Lung fibroblast cell lines RNA-FISH "Notably, Firre exhibits strong expression foci near its site of transcription in both male and female mouse and human ESCs (mESCs, hESCs). Thus, Firre is nuclear-localized and forms expression foci on both X-chromosomes prior to, and after X-chromosome inactivation." RLID00037901 286467 FIRRE http://www.ncbi.nlm.nih.gov/gene/?term=286467 LINC01200 lncRNA Homo sapiens 24463464 Nucleus Lung fibroblast cell lines RNA-FISH "Notably, Firre exhibits strong expression foci near its site of transcription in both male and female mouse and human ESCs (mESCs, hESCs). Thus, Firre is nuclear-localized and forms expression foci on both X-chromosomes prior to, and after X-chromosome inactivation." RLID00037902 103164605 Paupar http://www.ncbi.nlm.nih.gov/gene/?term=103164605 lncRNA Mus musculus 24488179 Nucleus N2A cells qRT-PCR "In these cells, we found Paupar RNA, but not a control mRNA, to be nuclear-enriched and located mainly in the chromatin fraction, and noted that ENCODE data show human Paupar to be similarly present in the nucleus and chromatin." RLID00037903 100507056 CCAT1 http://www.ncbi.nlm.nih.gov/gene/?term=CCAT1 CARLo-5; onco-lncRNA-40 lncRNA Homo sapiens 24662484 Cytoplasm Colorectal cancers RNA fractionation "In contrast, when a probe recognizing both isoforms of CCAT1 was used in the ISH, we found that fluorescent signals appeared in both cytoplasm and nucleus, suggesting that CCAT1-S is located in the cytoplasm." RLID00037904 100507056 CCAT1 http://www.ncbi.nlm.nih.gov/gene/?term=CCAT1 CARLo-5; onco-lncRNA-40 lncRNA Homo sapiens 24662484 Cytoplasm Colorectal cancers RNA-FISH "In contrast, when a probe recognizing both isoforms of CCAT1 was used in the ISH, we found that fluorescent signals appeared in both cytoplasm and nucleus, suggesting that CCAT1-S is located in the cytoplasm." RLID00037905 83729 INHBE http://www.ncbi.nlm.nih.gov/gene/?term=83729 mRNA Homo sapiens 24726458 Nucleus Rh36 cell RT-PCR "Through nuclear/cytoplasmic fractionation of Rh36 and CCA cells, followed by RNA isolation and real©\time RT/PCR, we found that the unspliced GLI1AS RNAs are preferentially retained in the nucleus, while the spliced GLI1AS RNAs transported to the cytoplasm." RLID00037906 83729 INHBE http://www.ncbi.nlm.nih.gov/gene/?term=83729 mRNA Homo sapiens 24726458 Cytoplasm Rh36 cell RT-PCR "Through nuclear/cytoplasmic fractionation of Rh36 and CCA cells, followed by RNA isolation and real©\time RT/PCR, we found that the unspliced GLI1AS RNAs are preferentially retained in the nucleus, while the spliced GLI1AS RNAs transported to the cytoplasm." RLID00037907 100048912 CDKN2B-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100048912 "ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS" lncRNA Homo sapiens 24810364 Nucleus BGC-823 qRT-PCR "We found a considerable increase in ANRIL expression in the nucleus versus the cytosol, thus suggesting that ANRIL is mainly localized in the nucleus and play a major regulatory function at the transcriptional level." RLID00037908 100048912 CDKN2B-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100048912 "ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS" lncRNA Homo sapiens 24810364 Nucleus SGC-7901 qRT-PCR "We found a considerable increase in ANRIL expression in the nucleus versus the cytosol, thus suggesting that ANRIL is mainly localized in the nucleus and play a major regulatory function at the transcriptional level." RLID00037909 283131 NEAT1 http://www.ncbi.nlm.nih.gov/gene/?term=283131 "LINC00084, NCRNA00084, TncRNA, VINC" lncRNA Homo sapiens 25155612 Nucleus BJ cell RNA-FISH "RNA FISH in BJ cells confirmed the punctate, nuclear localization of NEAT1 RNA." RLID00037910 400500 BCAR4 http://www.ncbi.nlm.nih.gov/gene/?term=400500 lncRNA Homo sapiens 25416949 Nucleus MDA-MB-231 RNA-FISH "We next examined the subcellular localization of BCAR4 by RNA FISH and real-time RT-qPCR analyses on fractionated RNA, finding that the BCAR4 transcript is predominately localized in the nucleus." RLID00037911 400500 BCAR4 http://www.ncbi.nlm.nih.gov/gene/?term=400500 lncRNA Homo sapiens 25416949 Nucleus MDA-MB-231 RT-qPCR "We next examined the subcellular localization of BCAR4 by RNA FISH and real-time RT-qPCR analyses on fractionated RNA, finding that the BCAR4 transcript is predominately localized in the nucleus." RLID00037912 147093 LINC00974 http://www.ncbi.nlm.nih.gov/gene/?term=147093 lncRNA Homo sapiens 25476897 Cytoplasm Huh7 cell lines/HepG2 cell lines RT-PCR The transcript for Linc00974 was located primarily in the cytoplasm of Huh7 and HepG2 cell lines according to the results of RT-PCR amplified with separated cytoplasm RNA and nuclear RNA. RLID00037913 23576 DDAH1 http://www.ncbi.nlm.nih.gov/gene/?term=23576 "DDAH, DDAH-1, DDAHI, HEL-S-16" mRNA Homo sapiens 25601475 Cytoplasm WI38-derived cells IMR90 and IMR90 hTERT MEK1-ER cell line qRT-PCR "Cell fractionation experiments showed that VAD was almost exclusively found in the chromatin fraction both in proliferative and senescent cells, whereas, as expected, mRNAs, such as the DDAH1-S mRNAs, were predominantly cytoplasmic." RLID00037914 105221694 BISPR http://www.ncbi.nlm.nih.gov/gene/?term=105221694 lncBST2 lncRNA Homo sapiens 25688240 Nucleus Primary human keratinocytes absence of IFN RT-qPCR "We analyzed the subcellular localization of BISPR, which showed that in the absence of IFN it was predominantly nuclear, while after IFN induction the RNA was present in both compartments." RLID00037915 105416157 NKILA http://www.ncbi.nlm.nih.gov/gene/?term=105416157 lncRNA Homo sapiens 25759022 Cytoplasm Breast Cancer Cells qRT-PCR "Confocal microscopy for fluorescent in situ hybridization (FISH) showed that NKILA located primarily in the cytoplasm, which was confirmed by nuclear/cytoplasm fractionation, suggesting that NKILA may exert its biological function in the cytoplasm." RLID00037916 105500046 Gm30731 http://www.ncbi.nlm.nih.gov/gene/?term=105500046 "Pnky, lnc-pou3f2" lncRNA Mus musculus 25800779 Nucleus Embryonic tissue RNA-FISH "Consistent with the nuclear fractionation studies, in situ hybridization (ISH) for Pnky demonstrated predominantly nuclear localization of the transcript." RLID00037917 283460 HNF1A-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=283460 "C12orf27, HAS1, NCRNA00262" lncRNA Homo sapiens 25863539 Nucleus NSCLC cell lines( including both adenocarcinoma and squamous carcinoma subtypes) qRT-PCR "We observed a considerable increase in HNF1A-AS1 expression in the nucleus versus the cytosol, thus suggesting that HNF1A-AS1 was mainly localized in the nucleus and maybe played a major regulatory function at the transcriptional level." RLID00037918 54485 Dll4 http://www.ncbi.nlm.nih.gov/gene/?term=54485 Delta4 mRNA Mus musculus 25914805 Nucleus "Endothelial cell line," RT-PCR Dll4-AS transcripts were localized in both cytoplasm and nucleus of mouse Ecs. RLID00037919 54485 Dll4 http://www.ncbi.nlm.nih.gov/gene/?term=54485 Delta4 mRNA Mus musculus 25914805 Cytoplasm "Endothelial cell line," RT-PCR Dll4-AS transcripts were localized in both cytoplasm and nucleus of mouse Ecs. RLID00037920 100124700 HOTAIR http://www.ncbi.nlm.nih.gov/gene/?term=100124700 "HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072" lncRNA Homo sapiens 26136075 Nucleus Gastric cancer tissues qRT-PCR "Furthermore, we verified that HOTAIR was located both in the nucleus and cytoplasm of gastric cancer cells, and RNA immunoprecipitation (RIP) assays showed that HOTAIR could bind to PRC2." RLID00037921 100124700 HOTAIR http://www.ncbi.nlm.nih.gov/gene/?term=100124700 "HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072" lncRNA Homo sapiens 26136075 Cytoplasm Gastric cancer tissues qRT-PCR "Furthermore, we verified that HOTAIR was located both in the nucleus and cytoplasm of gastric cancer cells, and RNA immunoprecipitation (RIP) assays showed that HOTAIR could bind to PRC2." RLID00037922 1000 CDH2 http://www.ncbi.nlm.nih.gov/gene/?term=1000 "CD325, CDHN, CDw325, NCAD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037923 10005 ACOT8 http://www.ncbi.nlm.nih.gov/gene/?term=10005 "HNAACTE, NAP1, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037924 10005 ACOT8 http://www.ncbi.nlm.nih.gov/gene/?term=10005 "HNAACTE, NAP1, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00037925 1001 CDH3 http://www.ncbi.nlm.nih.gov/gene/?term=1001 "CDHP, HJMD, PCAD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037926 1001 CDH3 http://www.ncbi.nlm.nih.gov/gene/?term=1001 "CDHP, HJMD, PCAD" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00037927 10010 TANK http://www.ncbi.nlm.nih.gov/gene/?term=10010 "I-TRAF, ITRAF, TRAF2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037928 100101467 ZSCAN30 http://www.ncbi.nlm.nih.gov/gene/?term=100101467 "ZNF-WYM, ZNF397OS, ZNF917" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037929 100128494 LOC100128494 http://www.ncbi.nlm.nih.gov/gene/?term=100128494 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037930 100128494 LOC100128494 http://www.ncbi.nlm.nih.gov/gene/?term=100128494 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037931 100129518 SOD2-OT1 http://www.ncbi.nlm.nih.gov/gene/?term=100129518 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037932 100129917 LOC100129917 http://www.ncbi.nlm.nih.gov/gene/?term=100129917 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037933 100129917 LOC100129917 http://www.ncbi.nlm.nih.gov/gene/?term=100129917 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037934 100129961 CCNT2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100129961 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037935 100131713 RPL29P11 http://www.ncbi.nlm.nih.gov/gene/?term=100131713 RPL29_2_362 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037936 100131713 RPL29P11 http://www.ncbi.nlm.nih.gov/gene/?term=100131713 RPL29_2_362 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037937 100132618 ZRANB2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100132618 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037938 100132891 MSC-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100132891 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037939 100134713 NDUFB2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100134713 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037940 100134713 NDUFB2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100134713 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037941 10018 BCL2L11 http://www.ncbi.nlm.nih.gov/gene/?term=10018 "BAM, BIM, BOD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037942 10018 BCL2L11 http://www.ncbi.nlm.nih.gov/gene/?term=10018 "BAM, BIM, BOD" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00037943 10019 SH2B3 http://www.ncbi.nlm.nih.gov/gene/?term=10019 "IDDM20, LNK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037944 10019 SH2B3 http://www.ncbi.nlm.nih.gov/gene/?term=10019 "IDDM20, LNK" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00037945 100271358 RPS15AP16 http://www.ncbi.nlm.nih.gov/gene/?term=100271358 RPS15A_7_402 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037946 100271358 RPS15AP16 http://www.ncbi.nlm.nih.gov/gene/?term=100271358 RPS15A_7_402 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037947 100288831 SRGAP3-AS3 http://www.ncbi.nlm.nih.gov/gene/?term=100288831 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037948 100288831 SRGAP3-AS3 http://www.ncbi.nlm.nih.gov/gene/?term=100288831 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037949 10040 TOM1L1 http://www.ncbi.nlm.nih.gov/gene/?term=10040 SRCASM mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037950 10043 TOM1 http://www.ncbi.nlm.nih.gov/gene/?term=10043 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037951 10043 TOM1 http://www.ncbi.nlm.nih.gov/gene/?term=10043 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00037952 10046 MAMLD1 http://www.ncbi.nlm.nih.gov/gene/?term=10046 "CG1, CXorf6, F18, HYSP2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037953 10048 RANBP9 http://www.ncbi.nlm.nih.gov/gene/?term=10048 "BPM-L, BPM90, RANBPM, RanBP7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037954 10048 RANBP9 http://www.ncbi.nlm.nih.gov/gene/?term=10048 "BPM-L, BPM90, RANBPM, RanBP7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00037955 10049 DNAJB6 http://www.ncbi.nlm.nih.gov/gene/?term=10049 "DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, MRJ, MSJ-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037956 10049 DNAJB6 http://www.ncbi.nlm.nih.gov/gene/?term=10049 "DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, MRJ, MSJ-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00037957 100505585 LOC100505585 http://www.ncbi.nlm.nih.gov/gene/?term=100505585 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037958 100505585 LOC100505585 http://www.ncbi.nlm.nih.gov/gene/?term=100505585 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037959 100505624 GTF3C2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100505624 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037960 100505624 GTF3C2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100505624 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037961 100505876 CEBPZOS http://www.ncbi.nlm.nih.gov/gene/?term=100505876 CEBPZ-AS1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037962 100505876 CEBPZOS http://www.ncbi.nlm.nih.gov/gene/?term=100505876 CEBPZ-AS1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00037963 100506020 ARAP1-AS2 http://www.ncbi.nlm.nih.gov/gene/?term=100506020 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037964 100506020 ARAP1-AS2 http://www.ncbi.nlm.nih.gov/gene/?term=100506020 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037965 100506100 LOC100506100 http://www.ncbi.nlm.nih.gov/gene/?term=100506100 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037966 100506100 LOC100506100 http://www.ncbi.nlm.nih.gov/gene/?term=100506100 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037967 100506243 KRBOX1 http://www.ncbi.nlm.nih.gov/gene/?term=100506243 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037968 100506403 LOC100506403 http://www.ncbi.nlm.nih.gov/gene/?term=100506403 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037969 100506403 LOC100506403 http://www.ncbi.nlm.nih.gov/gene/?term=100506403 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037970 100506779 TSPOAP1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506779 BZRAP1-AS1 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037971 100506779 TSPOAP1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506779 BZRAP1-AS1 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037972 100507582 BHLHE40-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100507582 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037973 100507582 BHLHE40-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100507582 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037974 10051 SMC4 http://www.ncbi.nlm.nih.gov/gene/?term=10051 "CAP-C, CAPC, SMC-4L1, SMC4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037975 10081 PDCD7 http://www.ncbi.nlm.nih.gov/gene/?term=10081 "ES18, HES18" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037976 10082 GPC6 http://www.ncbi.nlm.nih.gov/gene/?term=10082 OMIMD1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037977 10082 GPC6 http://www.ncbi.nlm.nih.gov/gene/?term=10082 OMIMD1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00037978 10085 EDIL3 http://www.ncbi.nlm.nih.gov/gene/?term=10085 DEL1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037979 10085 EDIL3 http://www.ncbi.nlm.nih.gov/gene/?term=10085 DEL1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00037980 100873952 SZT2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100873952 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037981 100873952 SZT2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100873952 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037982 100874040 PEX5L-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874040 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037983 100874040 PEX5L-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874040 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037984 100874048 DGUOK-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874048 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037985 100874048 DGUOK-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874048 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037986 100874075 ARAP1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874075 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037987 100874075 ARAP1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874075 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037988 100874108 A2ML1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874108 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037989 100874108 A2ML1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874108 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037990 100874212 MYCBP2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874212 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037991 100874212 MYCBP2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874212 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037992 100874515 POLR2KP1 http://www.ncbi.nlm.nih.gov/gene/?term=100874515 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037993 10098 TSPAN5 http://www.ncbi.nlm.nih.gov/gene/?term=10098 "NET-4, NET4, TM4SF9, TSPAN-5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037994 10098 TSPAN5 http://www.ncbi.nlm.nih.gov/gene/?term=10098 "NET-4, NET4, TM4SF9, TSPAN-5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00037995 100996485 C5orf66 http://www.ncbi.nlm.nih.gov/gene/?term=100996485 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00037996 100996485 C5orf66 http://www.ncbi.nlm.nih.gov/gene/?term=100996485 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00037997 100996693 LOC100996693 http://www.ncbi.nlm.nih.gov/gene/?term=100996693 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00037998 100996693 LOC100996693 http://www.ncbi.nlm.nih.gov/gene/?term=100996693 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00037999 10111 RAD50 http://www.ncbi.nlm.nih.gov/gene/?term=10111 "NBSLD2, hRad50, RAD50" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038000 10114 HIPK3 http://www.ncbi.nlm.nih.gov/gene/?term=10114 "DYRK6, FIST3, PKY, YAK1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038001 1012 CDH13 http://www.ncbi.nlm.nih.gov/gene/?term=1012 "CDHH, P105" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038002 1012 CDH13 http://www.ncbi.nlm.nih.gov/gene/?term=1012 "CDHH, P105" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038003 10138 YAF2 http://www.ncbi.nlm.nih.gov/gene/?term=10138 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038004 10138 YAF2 http://www.ncbi.nlm.nih.gov/gene/?term=10138 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038005 10142 AKAP9 http://www.ncbi.nlm.nih.gov/gene/?term=10142 "AKAP-9, AKAP350, AKAP450, CG-NAP, HYPERION, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038006 10142 AKAP9 http://www.ncbi.nlm.nih.gov/gene/?term=10142 "AKAP-9, AKAP350, AKAP450, CG-NAP, HYPERION, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038007 10144 FAM13A http://www.ncbi.nlm.nih.gov/gene/?term=10144 "ARHGAP481, FAM13A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038008 10144 FAM13A http://www.ncbi.nlm.nih.gov/gene/?term=10144 "ARHGAP481, FAM13A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038009 10149 ADGRG2 http://www.ncbi.nlm.nih.gov/gene/?term=10149 "CBAVDX, EDDM6, GPR64, HE6, TM7LN2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038010 10149 ADGRG2 http://www.ncbi.nlm.nih.gov/gene/?term=10149 "CBAVDX, EDDM6, GPR64, HE6, TM7LN2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038011 10150 MBNL2 http://www.ncbi.nlm.nih.gov/gene/?term=10150 "MBLL, MBLL39, PRO2032" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038012 10150 MBNL2 http://www.ncbi.nlm.nih.gov/gene/?term=10150 "MBLL, MBLL39, PRO2032" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038013 10159 ATP6AP2 http://www.ncbi.nlm.nih.gov/gene/?term=10159 "APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, HT028, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038014 10160 FARP1 http://www.ncbi.nlm.nih.gov/gene/?term=10160 "CDEP-IT1, PLEKHC2, PPP1R75, FARP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038015 10160 FARP1 http://www.ncbi.nlm.nih.gov/gene/?term=10160 "CDEP-IT1, PLEKHC2, PPP1R75, FARP1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038016 10165 SLC25A13 http://www.ncbi.nlm.nih.gov/gene/?term=10165 "ARALAR2, CITRIN, CTLN2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038017 10165 SLC25A13 http://www.ncbi.nlm.nih.gov/gene/?term=10165 "ARALAR2, CITRIN, CTLN2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038018 10180 RBM6 http://www.ncbi.nlm.nih.gov/gene/?term=10180 "3G2, DEF-3, DEF3, HLC-11, NY-LU-12, g16" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038019 10180 RBM6 http://www.ncbi.nlm.nih.gov/gene/?term=10180 "3G2, DEF-3, DEF3, HLC-11, NY-LU-12, g16" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038020 10181 RBM5 http://www.ncbi.nlm.nih.gov/gene/?term=10181 "G15, H37, LUCA15, RMB5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038021 10181 RBM5 http://www.ncbi.nlm.nih.gov/gene/?term=10181 "G15, H37, LUCA15, RMB5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038022 10186 LHFPL6 http://www.ncbi.nlm.nih.gov/gene/?term=10186 LHFP mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038023 10186 LHFPL6 http://www.ncbi.nlm.nih.gov/gene/?term=10186 LHFP mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038024 10188 TNK2 http://www.ncbi.nlm.nih.gov/gene/?term=10188 "ACK, ACK-1, ACK1, p21cdc42Hs" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038025 101926987 DLGAP4-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101926987 CCAT7 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038026 101926987 DLGAP4-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101926987 CCAT7 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038027 101927267 LOC101927267 http://www.ncbi.nlm.nih.gov/gene/?term=101927267 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038028 101927267 LOC101927267 http://www.ncbi.nlm.nih.gov/gene/?term=101927267 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038029 101927492 UTAT33 http://www.ncbi.nlm.nih.gov/gene/?term=101927492 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038030 101927550 LOC101927550 http://www.ncbi.nlm.nih.gov/gene/?term=101927550 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038031 101927550 LOC101927550 http://www.ncbi.nlm.nih.gov/gene/?term=101927550 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038032 101927718 DSG1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101927718 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038033 101927751 LOC101927751 http://www.ncbi.nlm.nih.gov/gene/?term=101927751 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038034 101928069 LOC101928069 http://www.ncbi.nlm.nih.gov/gene/?term=101928069 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038035 101928069 LOC101928069 http://www.ncbi.nlm.nih.gov/gene/?term=101928069 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038036 101928168 LOC101928168 http://www.ncbi.nlm.nih.gov/gene/?term=101928168 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038037 101928168 LOC101928168 http://www.ncbi.nlm.nih.gov/gene/?term=101928168 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038038 101928168 LOC101928168 http://www.ncbi.nlm.nih.gov/gene/?term=101928168 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038039 101928731 LOC101928731 http://www.ncbi.nlm.nih.gov/gene/?term=101928731 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038040 101928731 LOC101928731 http://www.ncbi.nlm.nih.gov/gene/?term=101928731 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038041 101928988 LOC101928988 http://www.ncbi.nlm.nih.gov/gene/?term=101928988 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038042 101928988 LOC101928988 http://www.ncbi.nlm.nih.gov/gene/?term=101928988 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038043 101929315 LOC101929315 http://www.ncbi.nlm.nih.gov/gene/?term=101929315 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038044 101929315 LOC101929315 http://www.ncbi.nlm.nih.gov/gene/?term=101929315 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038045 101929335 ADAMTS9-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101929335 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038046 101929335 ADAMTS9-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101929335 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038047 101929529 LOC101929529 http://www.ncbi.nlm.nih.gov/gene/?term=101929529 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038048 101929529 LOC101929529 http://www.ncbi.nlm.nih.gov/gene/?term=101929529 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038049 101929760 PIK3IP1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101929760 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038050 101929760 PIK3IP1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101929760 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038051 101930123 LOC101930123 http://www.ncbi.nlm.nih.gov/gene/?term=101930123 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038052 10196 PRMT3 http://www.ncbi.nlm.nih.gov/gene/?term=10196 HRMT1L3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038053 10196 PRMT3 http://www.ncbi.nlm.nih.gov/gene/?term=10196 HRMT1L3 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038054 10207 PATJ http://www.ncbi.nlm.nih.gov/gene/?term=10207 "Cipp, INADL, InaD-like, hINADL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038055 10217 CTDSPL http://www.ncbi.nlm.nih.gov/gene/?term=10217 "C3orf8, HYA22, PSR1, RBSP3, SCP3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038056 10217 CTDSPL http://www.ncbi.nlm.nih.gov/gene/?term=10217 "C3orf8, HYA22, PSR1, RBSP3, SCP3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038057 1022 CDK7 http://www.ncbi.nlm.nih.gov/gene/?term=1022 "CAK, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038058 10235 RASGRP2 http://www.ncbi.nlm.nih.gov/gene/?term=10235 "CALDAG-GEFI, CDC25L" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038059 10235 RASGRP2 http://www.ncbi.nlm.nih.gov/gene/?term=10235 "CALDAG-GEFI, CDC25L" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038060 10260 DENND4A http://www.ncbi.nlm.nih.gov/gene/?term=10260 "IRLB, MYCPBP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038061 1027 CDKN1B http://www.ncbi.nlm.nih.gov/gene/?term=1027 "CDKN4, KIP1, MEN1B, MEN4, P27KIP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038062 1027 CDKN1B http://www.ncbi.nlm.nih.gov/gene/?term=1027 "CDKN4, KIP1, MEN1B, MEN4, P27KIP1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038063 102723465 ELF3-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=102723465 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038064 102723465 ELF3-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=102723465 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038065 102723566 LOC102723566 http://www.ncbi.nlm.nih.gov/gene/?term=102723566 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038066 102723566 LOC102723566 http://www.ncbi.nlm.nih.gov/gene/?term=102723566 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038067 102725138 LOC102725138 http://www.ncbi.nlm.nih.gov/gene/?term=102725138 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038068 102725138 LOC102725138 http://www.ncbi.nlm.nih.gov/gene/?term=102725138 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038069 10274 STAG1 http://www.ncbi.nlm.nih.gov/gene/?term=10274 "SA1, SCC3A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038070 10277 UBE4B http://www.ncbi.nlm.nih.gov/gene/?term=10277 "E4, HDNB1, UBOX3, UFD2, UFD2A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038071 10277 UBE4B http://www.ncbi.nlm.nih.gov/gene/?term=10277 "E4, HDNB1, UBOX3, UFD2, UFD2A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038072 10283 CWC27 http://www.ncbi.nlm.nih.gov/gene/?term=10283 "NY-CO-10, RPSKA, SDCCAG-10, SDCCAG10" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038073 10283 CWC27 http://www.ncbi.nlm.nih.gov/gene/?term=10283 "NY-CO-10, RPSKA, SDCCAG-10, SDCCAG10" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038074 10290 SPEG http://www.ncbi.nlm.nih.gov/gene/?term=10290 "APEG-1, APEG1, BPEG, CNM5alpha, SPEGbeta, SPEG" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038075 10290 SPEG http://www.ncbi.nlm.nih.gov/gene/?term=10290 "APEG-1, APEG1, BPEG, CNM5alpha, SPEGbeta, SPEG" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038076 10299 MARCH6 http://www.ncbi.nlm.nih.gov/gene/?term=10299 "DOA10, MARCH-VI, RNF176, TEB4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038077 10299 MARCH6 http://www.ncbi.nlm.nih.gov/gene/?term=10299 "DOA10, MARCH-VI, RNF176, TEB4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038078 1030 CDKN2B http://www.ncbi.nlm.nih.gov/gene/?term=1030 "CDK4I, INK4B, MTS2, P15, TP15, p15INK4b" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038079 10313 RTN3 http://www.ncbi.nlm.nih.gov/gene/?term=10313 "ASYIP, HAP, NSPL2, NSPLII-A1, RTN3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038080 10313 RTN3 http://www.ncbi.nlm.nih.gov/gene/?term=10313 "ASYIP, HAP, NSPL2, NSPLII-A1, RTN3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038081 10314 LANCL1 http://www.ncbi.nlm.nih.gov/gene/?term=10314 "GPR69A, p40" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038082 10318 TNIP1 http://www.ncbi.nlm.nih.gov/gene/?term=10318 "ABIN-1, NAF1, VAN, nip40-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038083 10318 TNIP1 http://www.ncbi.nlm.nih.gov/gene/?term=10318 "ABIN-1, NAF1, VAN, nip40-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038084 10327 AKR1A1 http://www.ncbi.nlm.nih.gov/gene/?term=10327 "ALDR1, ALR, ARM, DD3, HEL-S-6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038085 10336 PCGF3 http://www.ncbi.nlm.nih.gov/gene/?term=10336 "DONG1, RNF3, RNF3A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038086 10336 PCGF3 http://www.ncbi.nlm.nih.gov/gene/?term=10336 "DONG1, RNF3, RNF3A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038087 10371 SEMA3A http://www.ncbi.nlm.nih.gov/gene/?term=10371 "COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD, coll-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038088 10390 CEPT1 http://www.ncbi.nlm.nih.gov/gene/?term=10390 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038089 10392 NOD1 http://www.ncbi.nlm.nih.gov/gene/?term=10392 "CARD4, CLR7.1, NLRC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038090 10392 NOD1 http://www.ncbi.nlm.nih.gov/gene/?term=10392 "CARD4, CLR7.1, NLRC1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038091 10393 ANAPC10 http://www.ncbi.nlm.nih.gov/gene/?term=10393 "APC10, DOC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038092 10395 DLC1 http://www.ncbi.nlm.nih.gov/gene/?term=10395 "ARHGAP7, HP, STARD12, p122-RhoGAP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038093 10397 NDRG1 http://www.ncbi.nlm.nih.gov/gene/?term=10397 "CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038094 10397 NDRG1 http://www.ncbi.nlm.nih.gov/gene/?term=10397 "CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038095 10402 ST3GAL6 http://www.ncbi.nlm.nih.gov/gene/?term=10402 "SIAT10, ST3GALVI" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038096 10402 ST3GAL6 http://www.ncbi.nlm.nih.gov/gene/?term=10402 "SIAT10, ST3GALVI" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038097 10404 CPQ http://www.ncbi.nlm.nih.gov/gene/?term=10404 "LDP, PGCP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038098 10404 CPQ http://www.ncbi.nlm.nih.gov/gene/?term=10404 "LDP, PGCP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038099 10406 WFDC2 http://www.ncbi.nlm.nih.gov/gene/?term=10406 "EDDM4, HE4, WAP5, dJ461P17.6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038100 10406 WFDC2 http://www.ncbi.nlm.nih.gov/gene/?term=10406 "EDDM4, HE4, WAP5, dJ461P17.6" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038101 10408 MYCNOS http://www.ncbi.nlm.nih.gov/gene/?term=10408 "MYCN-AS1, N-CYM, NCYM, NYCM" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038102 10408 MYCNOS http://www.ncbi.nlm.nih.gov/gene/?term=10408 "MYCN-AS1, N-CYM, NCYM, NYCM" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038103 10409 BASP1 http://www.ncbi.nlm.nih.gov/gene/?term=10409 "CAP-23, CAP23, NAP-22, NAP22" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038104 10409 BASP1 http://www.ncbi.nlm.nih.gov/gene/?term=10409 "CAP-23, CAP23, NAP-22, NAP22" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038105 10425 ARIH2 http://www.ncbi.nlm.nih.gov/gene/?term=10425 "ARI2, TRIAD1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038106 10425 ARIH2 http://www.ncbi.nlm.nih.gov/gene/?term=10425 "ARI2, TRIAD1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038107 10428 CFDP1 http://www.ncbi.nlm.nih.gov/gene/?term=10428 "BCNT, BUCENTAUR, CENP-29, CP27, SWC5, Yeti, p97" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038108 10428 CFDP1 http://www.ncbi.nlm.nih.gov/gene/?term=10428 "BCNT, BUCENTAUR, CENP-29, CP27, SWC5, Yeti, p97" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038109 10447 FAM3C http://www.ncbi.nlm.nih.gov/gene/?term=10447 "GS3786, ILEI" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038110 10447 FAM3C http://www.ncbi.nlm.nih.gov/gene/?term=10447 "GS3786, ILEI" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038111 10449 ACAA2 http://www.ncbi.nlm.nih.gov/gene/?term=10449 DSAEC mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038112 10451 VAV3 http://www.ncbi.nlm.nih.gov/gene/?term=10451 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038113 10451 VAV3 http://www.ncbi.nlm.nih.gov/gene/?term=10451 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038114 10452 TOMM40 http://www.ncbi.nlm.nih.gov/gene/?term=10452 "C19orf1, D19S1177E, PER-EC1, PEREC1, TOM40" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038115 10452 TOMM40 http://www.ncbi.nlm.nih.gov/gene/?term=10452 "C19orf1, D19S1177E, PER-EC1, PEREC1, TOM40" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038116 10460 TACC3 http://www.ncbi.nlm.nih.gov/gene/?term=10460 "ERIC-1, ERIC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038117 10460 TACC3 http://www.ncbi.nlm.nih.gov/gene/?term=10460 "ERIC-1, ERIC1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038118 10463 SLC30A9 http://www.ncbi.nlm.nih.gov/gene/?term=10463 "BILAPES, C4orf1, GAC63, HUEL, ZNT9" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038119 10463 SLC30A9 http://www.ncbi.nlm.nih.gov/gene/?term=10463 "BILAPES, C4orf1, GAC63, HUEL, ZNT9" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038120 10465 PPIH http://www.ncbi.nlm.nih.gov/gene/?term=10465 "CYP-20, CYPH, SnuCyp-20, USA-CYP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038121 10465 PPIH http://www.ncbi.nlm.nih.gov/gene/?term=10465 "CYP-20, CYPH, SnuCyp-20, USA-CYP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038122 10466 COG5 http://www.ncbi.nlm.nih.gov/gene/?term=10466 "CDG2I, GOLTC1, GTC90" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038123 10466 COG5 http://www.ncbi.nlm.nih.gov/gene/?term=10466 "CDG2I, GOLTC1, GTC90" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038124 10483 SEC23B http://www.ncbi.nlm.nih.gov/gene/?term=10483 "CDA-II, CDAII, CDAN2, CWS7, HEMPAS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038125 10483 SEC23B http://www.ncbi.nlm.nih.gov/gene/?term=10483 "CDA-II, CDAII, CDAN2, CWS7, HEMPAS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038126 10489 LRRC41 http://www.ncbi.nlm.nih.gov/gene/?term=10489 "MUF1, PP7759" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038127 10489 LRRC41 http://www.ncbi.nlm.nih.gov/gene/?term=10489 "MUF1, PP7759" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038128 10499 NCOA2 http://www.ncbi.nlm.nih.gov/gene/?term=10499 "GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038129 10512 SEMA3C http://www.ncbi.nlm.nih.gov/gene/?term=10512 "SEMAE, SemE" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038130 10512 SEMA3C http://www.ncbi.nlm.nih.gov/gene/?term=10512 "SEMAE, SemE" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038131 10513 APPBP2 http://www.ncbi.nlm.nih.gov/gene/?term=10513 "APP-BP2, HS.84084, PAT1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038132 10521 DDX17 http://www.ncbi.nlm.nih.gov/gene/?term=10521 "P72, RH70" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038133 10521 DDX17 http://www.ncbi.nlm.nih.gov/gene/?term=10521 "P72, RH70" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038134 10522 DEAF1 http://www.ncbi.nlm.nih.gov/gene/?term=10522 "MRD24, NUDR, SPN, ZMYND5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038135 10522 DEAF1 http://www.ncbi.nlm.nih.gov/gene/?term=10522 "MRD24, NUDR, SPN, ZMYND5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038136 10533 ATG7 http://www.ncbi.nlm.nih.gov/gene/?term=10533 "APG7-LIKE, APG7L, GSA7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038137 10533 ATG7 http://www.ncbi.nlm.nih.gov/gene/?term=10533 "APG7-LIKE, APG7L, GSA7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038138 105375095 LOC105375095 http://www.ncbi.nlm.nih.gov/gene/?term=105375095 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038139 105375095 LOC105375095 http://www.ncbi.nlm.nih.gov/gene/?term=105375095 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038140 10539 GLRX3 http://www.ncbi.nlm.nih.gov/gene/?term=10539 "GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038141 10539 GLRX3 http://www.ncbi.nlm.nih.gov/gene/?term=10539 "GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038142 10549 PRDX4 http://www.ncbi.nlm.nih.gov/gene/?term=10549 "AOE37-2, AOE372, HEL-S-97n, PRX-4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038143 10564 ARFGEF2 http://www.ncbi.nlm.nih.gov/gene/?term=10564 "BIG2, PVNH2, dJ1164I10.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038144 10564 ARFGEF2 http://www.ncbi.nlm.nih.gov/gene/?term=10564 "BIG2, PVNH2, dJ1164I10.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038145 10565 ARFGEF1 http://www.ncbi.nlm.nih.gov/gene/?term=10565 "ARFGEP1, BIG1, P200" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038146 10576 CCT2 http://www.ncbi.nlm.nih.gov/gene/?term=10576 "99D8.1, CCT-beta, CCTB, HEL-S-100n, PRO1633, TCP-1-beta" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038147 10576 CCT2 http://www.ncbi.nlm.nih.gov/gene/?term=10576 "99D8.1, CCT-beta, CCTB, HEL-S-100n, PRO1633, TCP-1-beta" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038148 10579 TACC2 http://www.ncbi.nlm.nih.gov/gene/?term=10579 "AZU-1, ECTACC" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038149 10579 TACC2 http://www.ncbi.nlm.nih.gov/gene/?term=10579 "AZU-1, ECTACC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038150 10580 SORBS1 http://www.ncbi.nlm.nih.gov/gene/?term=10580 "CAP, FLAF2, R85FL, SH3D5, SH3P12, SORB1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038151 10580 SORBS1 http://www.ncbi.nlm.nih.gov/gene/?term=10580 "CAP, FLAF2, R85FL, SH3D5, SH3P12, SORB1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038152 1060 CENPC http://www.ncbi.nlm.nih.gov/gene/?term=1060 "CENP-C1, MIF2, hcp-4, CENPC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038153 1060 CENPC http://www.ncbi.nlm.nih.gov/gene/?term=1060 "CENP-C1, MIF2, hcp-4, CENPC" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038154 10602 CDC42EP3 http://www.ncbi.nlm.nih.gov/gene/?term=10602 "BORG2, CEP3, UB1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038155 10602 CDC42EP3 http://www.ncbi.nlm.nih.gov/gene/?term=10602 "BORG2, CEP3, UB1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038156 106144526 PLA2G4C-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=106144526 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038157 106144526 PLA2G4C-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=106144526 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038158 10620 ARID3B http://www.ncbi.nlm.nih.gov/gene/?term=10620 "BDP, DRIL2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038159 10640 EXOC5 http://www.ncbi.nlm.nih.gov/gene/?term=10640 "HSEC10, PRO1912, SEC10, SEC10L1, SEC10P" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038160 10643 IGF2BP3 http://www.ncbi.nlm.nih.gov/gene/?term=10643 "CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038161 10658 CELF1 http://www.ncbi.nlm.nih.gov/gene/?term=10658 "BRUNOL2, CUG-BP, CUGBP, CUGBP1, EDEN-BP, NAB50, NAPOR, hNab50" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038162 10659 CELF2 http://www.ncbi.nlm.nih.gov/gene/?term=10659 "BRUNOL3, CELF-2, CUG-BP2, CUGBP2, ETR-3, ETR3, NAPOR" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038163 10659 CELF2 http://www.ncbi.nlm.nih.gov/gene/?term=10659 "BRUNOL3, CELF-2, CUG-BP2, CUGBP2, ETR-3, ETR3, NAPOR" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038164 10667 FARS2 http://www.ncbi.nlm.nih.gov/gene/?term=10667 "COXPD14, FARS1, HSPC320, PheRS, SPG77" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038165 10678 B3GNT2 http://www.ncbi.nlm.nih.gov/gene/?term=10678 "3-Gn-T1, 3-Gn-T2, B3GN-T2, B3GNT, B3GNT-2, B3GNT1, BETA3GNT, BGNT2, BGnT-2, beta-1, beta3Gn-T1, beta3Gn-T2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038166 10678 B3GNT2 http://www.ncbi.nlm.nih.gov/gene/?term=10678 "3-Gn-T1, 3-Gn-T2, B3GN-T2, B3GNT, B3GNT-2, B3GNT1, BETA3GNT, BGNT2, BGnT-2, beta-1, beta3Gn-T1, beta3Gn-T2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038167 107 ADCY1 http://www.ncbi.nlm.nih.gov/gene/?term=107 "AC1, DFNB44" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038168 107 ADCY1 http://www.ncbi.nlm.nih.gov/gene/?term=107 "AC1, DFNB44" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038169 10721 POLQ http://www.ncbi.nlm.nih.gov/gene/?term=10721 PRO0327 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038170 10721 POLQ http://www.ncbi.nlm.nih.gov/gene/?term=10721 PRO0327 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038171 10725 NFAT5 http://www.ncbi.nlm.nih.gov/gene/?term=10725 "NF-AT5, NFATL1, NFATZ, OREBP, TONEBP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038172 10725 NFAT5 http://www.ncbi.nlm.nih.gov/gene/?term=10725 "NF-AT5, NFATL1, NFATZ, OREBP, TONEBP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038173 10735 STAG2 http://www.ncbi.nlm.nih.gov/gene/?term=10735 "SA-2, SA2, SCC3B, bA517O1.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038174 10735 STAG2 http://www.ncbi.nlm.nih.gov/gene/?term=10735 "SA-2, SA2, SCC3B, bA517O1.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038175 10745 PHTF1 http://www.ncbi.nlm.nih.gov/gene/?term=10745 PHTF mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038176 10745 PHTF1 http://www.ncbi.nlm.nih.gov/gene/?term=10745 PHTF mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038177 10758 TRAF3IP2 http://www.ncbi.nlm.nih.gov/gene/?term=10758 "ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038178 10758 TRAF3IP2 http://www.ncbi.nlm.nih.gov/gene/?term=10758 "ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038179 10771 ZMYND11 http://www.ncbi.nlm.nih.gov/gene/?term=10771 "BRAM1, BS69, MRD30" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038180 10771 ZMYND11 http://www.ncbi.nlm.nih.gov/gene/?term=10771 "BRAM1, BS69, MRD30" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038181 10776 ARPP19 http://www.ncbi.nlm.nih.gov/gene/?term=10776 "ARPP-16, ARPP-19, ARPP16, ENSAL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038182 10776 ARPP19 http://www.ncbi.nlm.nih.gov/gene/?term=10776 "ARPP-16, ARPP-19, ARPP16, ENSAL" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038183 10777 ARPP21 http://www.ncbi.nlm.nih.gov/gene/?term=10777 "ARPP-21, R3HDM3, RCS, TARPP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038184 10777 ARPP21 http://www.ncbi.nlm.nih.gov/gene/?term=10777 "ARPP-21, R3HDM3, RCS, TARPP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038185 10783 NEK6 http://www.ncbi.nlm.nih.gov/gene/?term=10783 SID6-1512 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038186 10783 NEK6 http://www.ncbi.nlm.nih.gov/gene/?term=10783 SID6-1512 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038187 10785 WDR4 http://www.ncbi.nlm.nih.gov/gene/?term=10785 "TRM82, TRMT82" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038188 10785 WDR4 http://www.ncbi.nlm.nih.gov/gene/?term=10785 "TRM82, TRMT82" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038189 107986404 LOC107986404 http://www.ncbi.nlm.nih.gov/gene/?term=107986404 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038190 10801 SEPT9 http://www.ncbi.nlm.nih.gov/gene/?term=10801 "AF17q25, MSF, MSF1, NAPB, PNUTL4, SINT1, SeptD1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038191 10801 SEPT9 http://www.ncbi.nlm.nih.gov/gene/?term=10801 "AF17q25, MSF, MSF1, NAPB, PNUTL4, SINT1, SeptD1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038192 10818 FRS2 http://www.ncbi.nlm.nih.gov/gene/?term=10818 "FRS1AA, FRS2alpha, SNT, SNT-1, SNT1, FRS2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038193 10818 FRS2 http://www.ncbi.nlm.nih.gov/gene/?term=10818 "FRS1AA, FRS2alpha, SNT, SNT-1, SNT1, FRS2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038194 10825 NEU3 http://www.ncbi.nlm.nih.gov/gene/?term=10825 SIAL3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038195 10825 NEU3 http://www.ncbi.nlm.nih.gov/gene/?term=10825 SIAL3 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038196 10847 SRCAP http://www.ncbi.nlm.nih.gov/gene/?term=10847 "DOMO1, EAF1, FLHS, SWR1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038197 10847 SRCAP http://www.ncbi.nlm.nih.gov/gene/?term=10847 "DOMO1, EAF1, FLHS, SWR1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038198 10867 TSPAN9 http://www.ncbi.nlm.nih.gov/gene/?term=10867 "NET-5, NET5, PP1057" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038199 10867 TSPAN9 http://www.ncbi.nlm.nih.gov/gene/?term=10867 "NET-5, NET5, PP1057" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038200 10873 ME3 http://www.ncbi.nlm.nih.gov/gene/?term=10873 NADP-ME mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038201 10873 ME3 http://www.ncbi.nlm.nih.gov/gene/?term=10873 NADP-ME mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038202 10890 RAB10 http://www.ncbi.nlm.nih.gov/gene/?term=10890 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038203 10890 RAB10 http://www.ncbi.nlm.nih.gov/gene/?term=10890 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038204 10892 MALT1 http://www.ncbi.nlm.nih.gov/gene/?term=10892 "IMD12, MLT, MLT1, PCASP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038205 10904 BLCAP http://www.ncbi.nlm.nih.gov/gene/?term=10904 BC10 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038206 10904 BLCAP http://www.ncbi.nlm.nih.gov/gene/?term=10904 BC10 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038207 10905 MAN1A2 http://www.ncbi.nlm.nih.gov/gene/?term=10905 MAN1B mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038208 10905 MAN1A2 http://www.ncbi.nlm.nih.gov/gene/?term=10905 MAN1B mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038209 10907 TXNL4A http://www.ncbi.nlm.nih.gov/gene/?term=10907 "BMKS, DIB1, DIM1, SNRNP15, TXNL4, U5-15kD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038210 10915 TCERG1 http://www.ncbi.nlm.nih.gov/gene/?term=10915 "CA150, TAF2S, Urn1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038211 10927 SPIN1 http://www.ncbi.nlm.nih.gov/gene/?term=10927 "SPIN, TDRD24" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038212 10927 SPIN1 http://www.ncbi.nlm.nih.gov/gene/?term=10927 "SPIN, TDRD24" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038213 10933 MORF4L1 http://www.ncbi.nlm.nih.gov/gene/?term=10933 "Eaf3, FWP006, HsT17725, MEAF3, MORFRG15, MRG15, S863-6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038214 10945 KDELR1 http://www.ncbi.nlm.nih.gov/gene/?term=10945 "ERD2, ERD2.1, HDEL, PM23" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038215 10972 TMED10 http://www.ncbi.nlm.nih.gov/gene/?term=10972 "P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, p24d1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038216 109864269 LOC109864269 http://www.ncbi.nlm.nih.gov/gene/?term=109864269 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038217 109864269 LOC109864269 http://www.ncbi.nlm.nih.gov/gene/?term=109864269 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038218 11010 GLIPR1 http://www.ncbi.nlm.nih.gov/gene/?term=11010 "CRISP7, GLIPR, RTVP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038219 11010 GLIPR1 http://www.ncbi.nlm.nih.gov/gene/?term=11010 "CRISP7, GLIPR, RTVP1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038220 11011 TLK2 http://www.ncbi.nlm.nih.gov/gene/?term=11011 "HsHPK, PKU-ALPHA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038221 11014 KDELR2 http://www.ncbi.nlm.nih.gov/gene/?term=11014 "ELP-1, ERD2.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038222 11014 KDELR2 http://www.ncbi.nlm.nih.gov/gene/?term=11014 "ELP-1, ERD2.2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038223 11016 ATF7 http://www.ncbi.nlm.nih.gov/gene/?term=11016 ATFA mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038224 1102 RCBTB2 http://www.ncbi.nlm.nih.gov/gene/?term=1102 "CHC1L, RLG" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038225 1102 RCBTB2 http://www.ncbi.nlm.nih.gov/gene/?term=1102 "CHC1L, RLG" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038226 11030 RBPMS http://www.ncbi.nlm.nih.gov/gene/?term=11030 HERMES mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038227 11030 RBPMS http://www.ncbi.nlm.nih.gov/gene/?term=11030 HERMES mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038228 11031 RAB31 http://www.ncbi.nlm.nih.gov/gene/?term=11031 Rab22B mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038229 11034 DSTN http://www.ncbi.nlm.nih.gov/gene/?term=11034 "ACTDP, ADF, HEL32, bA462D18.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038230 11034 DSTN http://www.ncbi.nlm.nih.gov/gene/?term=11034 "ACTDP, ADF, HEL32, bA462D18.2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038231 11044 PAPD7 http://www.ncbi.nlm.nih.gov/gene/?term=11044 "LAK-1, LAK1, POLK, POLS, TRF4, TRF4-1, TRF41, TUTASE5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038232 11044 PAPD7 http://www.ncbi.nlm.nih.gov/gene/?term=11044 "LAK-1, LAK1, POLK, POLS, TRF4, TRF4-1, TRF41, TUTASE5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038233 1105 CHD1 http://www.ncbi.nlm.nih.gov/gene/?term=1105 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038234 11052 CPSF6 http://www.ncbi.nlm.nih.gov/gene/?term=11052 "CFIM, CFIM68, CFIM72, HPBRII-4, HPBRII-7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038235 11052 CPSF6 http://www.ncbi.nlm.nih.gov/gene/?term=11052 "CFIM, CFIM68, CFIM72, HPBRII-4, HPBRII-7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038236 11054 OGFR http://www.ncbi.nlm.nih.gov/gene/?term=11054 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038237 11054 OGFR http://www.ncbi.nlm.nih.gov/gene/?term=11054 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038238 11057 ABHD2 http://www.ncbi.nlm.nih.gov/gene/?term=11057 "HS1-2, LABH2, PHPS1-2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038239 11057 ABHD2 http://www.ncbi.nlm.nih.gov/gene/?term=11057 "HS1-2, LABH2, PHPS1-2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038240 11059 WWP1 http://www.ncbi.nlm.nih.gov/gene/?term=11059 "AIP5, Tiul1, hSDRP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038241 1106 CHD2 http://www.ncbi.nlm.nih.gov/gene/?term=1106 EEOC mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038242 1106 CHD2 http://www.ncbi.nlm.nih.gov/gene/?term=1106 EEOC mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038243 11083 DIDO1 http://www.ncbi.nlm.nih.gov/gene/?term=11083 "BYE1, C20orf158, DATF-1, DATF1, DIDO2, DIDO3, DIO-1, DIO1, dJ885L7.8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038244 11083 DIDO1 http://www.ncbi.nlm.nih.gov/gene/?term=11083 "BYE1, C20orf158, DATF-1, DATF1, DIDO2, DIDO3, DIO-1, DIO1, dJ885L7.8" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038245 11094 CACFD1 http://www.ncbi.nlm.nih.gov/gene/?term=11094 "C9orf7, D9S2135, FLOWER" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038246 11097 NUPL2 http://www.ncbi.nlm.nih.gov/gene/?term=11097 "CG1, NLP-1, NLP_1, hCG1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038247 11103 KRR1 http://www.ncbi.nlm.nih.gov/gene/?term=11103 "HRB2, RIP-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038248 11107 PRDM5 http://www.ncbi.nlm.nih.gov/gene/?term=11107 "BCS2, PFM2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038249 11113 CIT http://www.ncbi.nlm.nih.gov/gene/?term=11113 "CITK, CRIK, MCPH17, STK21" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038250 11113 CIT http://www.ncbi.nlm.nih.gov/gene/?term=11113 "CITK, CRIK, MCPH17, STK21" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038251 1112 FOXN3 http://www.ncbi.nlm.nih.gov/gene/?term=1112 "C14orf116, CHES1, PRO1635" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038252 1112 FOXN3 http://www.ncbi.nlm.nih.gov/gene/?term=1112 "C14orf116, CHES1, PRO1635" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038253 11124 FAF1 http://www.ncbi.nlm.nih.gov/gene/?term=11124 "CGI-03, HFAF1s, UBXD12, UBXN3A, hFAF1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038254 11127 KIF3A http://www.ncbi.nlm.nih.gov/gene/?term=11127 "FLA10, KLP-20" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038255 11127 KIF3A http://www.ncbi.nlm.nih.gov/gene/?term=11127 "FLA10, KLP-20" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038256 11138 TBC1D8 http://www.ncbi.nlm.nih.gov/gene/?term=11138 "AD3, GRAMD8, HBLP1A, VRP, TBC1D8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038257 11138 TBC1D8 http://www.ncbi.nlm.nih.gov/gene/?term=11138 "AD3, GRAMD8, HBLP1A, VRP, TBC1D8" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038258 11146 GLMN http://www.ncbi.nlm.nih.gov/gene/?term=11146 "FAP, FAP48, FAP68, FKBPAP, GLML, GVM, VMGLOM" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038259 11157 LSM6 http://www.ncbi.nlm.nih.gov/gene/?term=11157 YDR378C mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038260 11157 LSM6 http://www.ncbi.nlm.nih.gov/gene/?term=11157 YDR378C mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038261 11167 FSTL1 http://www.ncbi.nlm.nih.gov/gene/?term=11167 "FRP, FSL1, MIR198, OCC-1, OCC1, tsc36" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038262 11167 FSTL1 http://www.ncbi.nlm.nih.gov/gene/?term=11167 "FRP, FSL1, MIR198, OCC-1, OCC1, tsc36" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038263 11177 BAZ1A http://www.ncbi.nlm.nih.gov/gene/?term=11177 "ACF1, WALp1, WCRF180, hACF1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038264 11177 BAZ1A http://www.ncbi.nlm.nih.gov/gene/?term=11177 "ACF1, WALp1, WCRF180, hACF1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038265 11183 MAP4K5 http://www.ncbi.nlm.nih.gov/gene/?term=11183 "GCKR, KHS, KHS1, MAPKKKK5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038266 11183 MAP4K5 http://www.ncbi.nlm.nih.gov/gene/?term=11183 "GCKR, KHS, KHS1, MAPKKKK5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038267 11186 RASSF1 http://www.ncbi.nlm.nih.gov/gene/?term=11186 "123F2, NORE2AA, RDA32, REH3P21, RASSF1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038268 11186 RASSF1 http://www.ncbi.nlm.nih.gov/gene/?term=11186 "123F2, NORE2AA, RDA32, REH3P21, RASSF1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038269 11196 SEC23IP http://www.ncbi.nlm.nih.gov/gene/?term=11196 "MSTP053, P125, P125A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038270 11198 SUPT16H http://www.ncbi.nlm.nih.gov/gene/?term=11198 "CDC68, FACTP140, SPT16, SPT16/CDC68" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038271 11198 SUPT16H http://www.ncbi.nlm.nih.gov/gene/?term=11198 "CDC68, FACTP140, SPT16, SPT16/CDC68" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038272 11200 CHEK2 http://www.ncbi.nlm.nih.gov/gene/?term=11200 "CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038273 11214 AKAP13 http://www.ncbi.nlm.nih.gov/gene/?term=11214 "AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038274 11214 AKAP13 http://www.ncbi.nlm.nih.gov/gene/?term=11214 "AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038275 11215 AKAP11 http://www.ncbi.nlm.nih.gov/gene/?term=11215 "AKAP-11, AKAP220, PPP1R44, PRKA11" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038276 11216 AKAP10 http://www.ncbi.nlm.nih.gov/gene/?term=11216 "AKAP-10, D-AKAP-2, D-AKAP2, PRKA10" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038277 11216 AKAP10 http://www.ncbi.nlm.nih.gov/gene/?term=11216 "AKAP-10, D-AKAP-2, D-AKAP2, PRKA10" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038278 11228 RASSF8 http://www.ncbi.nlm.nih.gov/gene/?term=11228 "C12orf2, HOJ1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038279 11228 RASSF8 http://www.ncbi.nlm.nih.gov/gene/?term=11228 "C12orf2, HOJ1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038280 11234 HPS5 http://www.ncbi.nlm.nih.gov/gene/?term=11234 "AIBP63, BLOC2S2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038281 11234 HPS5 http://www.ncbi.nlm.nih.gov/gene/?term=11234 "AIBP63, BLOC2S2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038282 11238 CA5B http://www.ncbi.nlm.nih.gov/gene/?term=11238 CA-VB mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038283 11238 CA5B http://www.ncbi.nlm.nih.gov/gene/?term=11238 CA-VB mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038284 1124 CHN2 http://www.ncbi.nlm.nih.gov/gene/?term=1124 "ARHGAP3, BCH-3, RHOGAP3, CHN2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038285 1124 CHN2 http://www.ncbi.nlm.nih.gov/gene/?term=1124 "ARHGAP3, BCH-3, RHOGAP3, CHN2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038286 112479 ERI2 http://www.ncbi.nlm.nih.gov/gene/?term=112479 "EXOD1, ZGRF5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038287 112479 ERI2 http://www.ncbi.nlm.nih.gov/gene/?term=112479 "EXOD1, ZGRF5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038288 112752 IFT43 http://www.ncbi.nlm.nih.gov/gene/?term=112752 "C14orf179, CED3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038289 11276 SYNRG http://www.ncbi.nlm.nih.gov/gene/?term=11276 "SYNG, AP1GBP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038290 11278 KLF12 http://www.ncbi.nlm.nih.gov/gene/?term=11278 "AP-2rep, AP2REP, HSPC122" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038291 1130 LYST http://www.ncbi.nlm.nih.gov/gene/?term=1130 "CHS, CHS1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038292 11311 VPS45 http://www.ncbi.nlm.nih.gov/gene/?term=11311 "H1, H1VPS45, SCN5A, VPS45B, VPS54A, VSP45, VSP45A, VPS45" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038293 113174 SAAL1 http://www.ncbi.nlm.nih.gov/gene/?term=113174 SPACIA1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038294 113174 SAAL1 http://www.ncbi.nlm.nih.gov/gene/?term=113174 SPACIA1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038295 113251 LARP4 http://www.ncbi.nlm.nih.gov/gene/?term=113251 PP13296 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038296 113251 LARP4 http://www.ncbi.nlm.nih.gov/gene/?term=113251 PP13296 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038297 11329 STK38 http://www.ncbi.nlm.nih.gov/gene/?term=11329 "NDR, NDR1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038298 11332 ACOT7 http://www.ncbi.nlm.nih.gov/gene/?term=11332 "ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038299 11332 ACOT7 http://www.ncbi.nlm.nih.gov/gene/?term=11332 "ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038300 11336 EXOC3 http://www.ncbi.nlm.nih.gov/gene/?term=11336 "SEC6, SEC6L1, Sec6p" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038301 11343 MGLL http://www.ncbi.nlm.nih.gov/gene/?term=11343 "HU-K5, HUK5, MAGL, MGL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038302 11343 MGLL http://www.ncbi.nlm.nih.gov/gene/?term=11343 "HU-K5, HUK5, MAGL, MGL" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038303 113451 AZIN2 http://www.ncbi.nlm.nih.gov/gene/?term=113451 "ADC, AZI2, AZIB1, ODC-p, ODC1L, ODCp" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038304 11346 SYNPO http://www.ncbi.nlm.nih.gov/gene/?term=11346 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038305 11346 SYNPO http://www.ncbi.nlm.nih.gov/gene/?term=11346 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038306 114049 BUD23 http://www.ncbi.nlm.nih.gov/gene/?term=114049 "HASJ4442, HUSSY-3, MERM1, PP3381, WBMT, WBSCR22" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038307 114049 BUD23 http://www.ncbi.nlm.nih.gov/gene/?term=114049 "HASJ4442, HUSSY-3, MERM1, PP3381, WBMT, WBSCR22" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038308 114134 SLC2A13 http://www.ncbi.nlm.nih.gov/gene/?term=114134 HMIT mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038309 114327 EFHC1 http://www.ncbi.nlm.nih.gov/gene/?term=114327 "EJM1, dJ304B14.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038310 114327 EFHC1 http://www.ncbi.nlm.nih.gov/gene/?term=114327 "EJM1, dJ304B14.2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038311 1147 CHUK http://www.ncbi.nlm.nih.gov/gene/?term=1147 "IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038312 114784 CSMD2 http://www.ncbi.nlm.nih.gov/gene/?term=114784 "dJ1007G16.1, dJ1007G16.2, dJ947L8.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038313 114784 CSMD2 http://www.ncbi.nlm.nih.gov/gene/?term=114784 "dJ1007G16.1, dJ1007G16.2, dJ947L8.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038314 114788 CSMD3 http://www.ncbi.nlm.nih.gov/gene/?term=114788 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038315 114788 CSMD3 http://www.ncbi.nlm.nih.gov/gene/?term=114788 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038316 114793 FMNL2 http://www.ncbi.nlm.nih.gov/gene/?term=114793 FHOD2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038317 114793 FMNL2 http://www.ncbi.nlm.nih.gov/gene/?term=114793 FHOD2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038318 114805 GALNT13 http://www.ncbi.nlm.nih.gov/gene/?term=114805 GalNAc-T13 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038319 114805 GALNT13 http://www.ncbi.nlm.nih.gov/gene/?term=114805 GalNAc-T13 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038320 114879 OSBPL5 http://www.ncbi.nlm.nih.gov/gene/?term=114879 "OBPH1, ORP5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038321 114879 OSBPL5 http://www.ncbi.nlm.nih.gov/gene/?term=114879 "OBPH1, ORP5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038322 114884 OSBPL10 http://www.ncbi.nlm.nih.gov/gene/?term=114884 "ORP10, OSBP9" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038323 114884 OSBPL10 http://www.ncbi.nlm.nih.gov/gene/?term=114884 "ORP10, OSBP9" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038324 114905 C1QTNF7 http://www.ncbi.nlm.nih.gov/gene/?term=114905 "CTRP7, ZACRP7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038325 114905 C1QTNF7 http://www.ncbi.nlm.nih.gov/gene/?term=114905 "CTRP7, ZACRP7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038326 115 ADCY9 http://www.ncbi.nlm.nih.gov/gene/?term=115 "AC9, ACIX" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038327 115 ADCY9 http://www.ncbi.nlm.nih.gov/gene/?term=115 "AC9, ACIX" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038328 115294 PCMTD1 http://www.ncbi.nlm.nih.gov/gene/?term=115294 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038329 115294 PCMTD1 http://www.ncbi.nlm.nih.gov/gene/?term=115294 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038330 115350 FCRL1 http://www.ncbi.nlm.nih.gov/gene/?term=115350 "CD307a, FCRH1, IFGP1, IRTA5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038331 115350 FCRL1 http://www.ncbi.nlm.nih.gov/gene/?term=115350 "CD307a, FCRH1, IFGP1, IRTA5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038332 115825 WDFY2 http://www.ncbi.nlm.nih.gov/gene/?term=115825 "PROF, WDF2, ZFYVE22" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038333 116159 CYYR1 http://www.ncbi.nlm.nih.gov/gene/?term=116159 C21orf95 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038334 116159 CYYR1 http://www.ncbi.nlm.nih.gov/gene/?term=116159 C21orf95 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038335 116225 ZMYND19 http://www.ncbi.nlm.nih.gov/gene/?term=116225 MIZIP mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038336 116225 ZMYND19 http://www.ncbi.nlm.nih.gov/gene/?term=116225 MIZIP mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038337 116372 LYPD1 http://www.ncbi.nlm.nih.gov/gene/?term=116372 "LYPDC1, PHTS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038338 116372 LYPD1 http://www.ncbi.nlm.nih.gov/gene/?term=116372 "LYPDC1, PHTS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038339 116461 TSEN15 http://www.ncbi.nlm.nih.gov/gene/?term=116461 "C1orf19, PCH2F, sen15" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038340 116461 TSEN15 http://www.ncbi.nlm.nih.gov/gene/?term=116461 "C1orf19, PCH2F, sen15" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038341 116985 ARAP1 http://www.ncbi.nlm.nih.gov/gene/?term=116985 CENTD2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038342 116985 ARAP1 http://www.ncbi.nlm.nih.gov/gene/?term=116985 CENTD2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038343 116987 AGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=116987 "AGAP-1, CENTG2, GGAP1, cnt-g2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038344 116988 AGAP3 http://www.ncbi.nlm.nih.gov/gene/?term=116988 "AGAP-3, CENTG3, CRAG, MRIP-1, cnt-g3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038345 117583 PARD3B http://www.ncbi.nlm.nih.gov/gene/?term=117583 "ALS2CR19, PAR3B, PAR3L, PAR3beta" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038346 117583 PARD3B http://www.ncbi.nlm.nih.gov/gene/?term=117583 "ALS2CR19, PAR3B, PAR3L, PAR3beta" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038347 118812 MORN4 http://www.ncbi.nlm.nih.gov/gene/?term=118812 "C10orf83, bA548K23.4, rtp" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038348 118812 MORN4 http://www.ncbi.nlm.nih.gov/gene/?term=118812 "C10orf83, bA548K23.4, rtp" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038349 119391 GSTO2 http://www.ncbi.nlm.nih.gov/gene/?term=119391 "GSTO 2-2, bA127L20.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038350 1198 CLK3 http://www.ncbi.nlm.nih.gov/gene/?term=1198 "PHCLK3, PHCLK3/152" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038351 1198 CLK3 http://www.ncbi.nlm.nih.gov/gene/?term=1198 "PHCLK3, PHCLK3/152" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038352 120 ADD3 http://www.ncbi.nlm.nih.gov/gene/?term=120 "ADDL, CPSQ3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038353 120 ADD3 http://www.ncbi.nlm.nih.gov/gene/?term=120 "ADDL, CPSQ3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038354 1207 CLNS1A http://www.ncbi.nlm.nih.gov/gene/?term=1207 "CLCI, CLNS1B, ICln" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038355 1207 CLNS1A http://www.ncbi.nlm.nih.gov/gene/?term=1207 "CLCI, CLNS1B, ICln" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038356 121260 SLC15A4 http://www.ncbi.nlm.nih.gov/gene/?term=121260 "FP12591, PHT1, PTR4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038357 121260 SLC15A4 http://www.ncbi.nlm.nih.gov/gene/?term=121260 "FP12591, PHT1, PTR4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038358 121665 SPPL3 http://www.ncbi.nlm.nih.gov/gene/?term=121665 "IMP2, MDHV1887, PRO4332, PSH1, PSL4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038359 122945 NOXRED1 http://www.ncbi.nlm.nih.gov/gene/?term=122945 C14orf148 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038360 122945 NOXRED1 http://www.ncbi.nlm.nih.gov/gene/?term=122945 C14orf148 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038361 122953 JDP2 http://www.ncbi.nlm.nih.gov/gene/?term=122953 JUNDM2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038362 122953 JDP2 http://www.ncbi.nlm.nih.gov/gene/?term=122953 JUNDM2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038363 123016 TTC8 http://www.ncbi.nlm.nih.gov/gene/?term=123016 "BBS8, RP51" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038364 123169 LEO1 http://www.ncbi.nlm.nih.gov/gene/?term=123169 RDL mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038365 123169 LEO1 http://www.ncbi.nlm.nih.gov/gene/?term=123169 RDL mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038366 123591 TMEM266 http://www.ncbi.nlm.nih.gov/gene/?term=123591 "C15orf27, HVRP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038367 123591 TMEM266 http://www.ncbi.nlm.nih.gov/gene/?term=123591 "C15orf27, HVRP1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038368 1236 CCR7 http://www.ncbi.nlm.nih.gov/gene/?term=1236 "BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038369 1236 CCR7 http://www.ncbi.nlm.nih.gov/gene/?term=1236 "BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038370 123775 C16orf46 http://www.ncbi.nlm.nih.gov/gene/?term=123775 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038371 123775 C16orf46 http://www.ncbi.nlm.nih.gov/gene/?term=123775 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038372 123811 FOPNL http://www.ncbi.nlm.nih.gov/gene/?term=123811 "C16orf63, FOR20, PHSECRG2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038373 124152 IQCK http://www.ncbi.nlm.nih.gov/gene/?term=124152 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038374 124152 IQCK http://www.ncbi.nlm.nih.gov/gene/?term=124152 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038375 124402 UBALD1 http://www.ncbi.nlm.nih.gov/gene/?term=124402 "FAM100A, PP11303" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038376 124402 UBALD1 http://www.ncbi.nlm.nih.gov/gene/?term=124402 "FAM100A, PP11303" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038377 124454 EARS2 http://www.ncbi.nlm.nih.gov/gene/?term=124454 "COXPD12, MSE1, gluRS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038378 124454 EARS2 http://www.ncbi.nlm.nih.gov/gene/?term=124454 "COXPD12, MSE1, gluRS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038379 124460 SNX20 http://www.ncbi.nlm.nih.gov/gene/?term=124460 SLIC1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038380 124460 SNX20 http://www.ncbi.nlm.nih.gov/gene/?term=124460 SLIC1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038381 124540 MSI2 http://www.ncbi.nlm.nih.gov/gene/?term=124540 MSI2H mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038382 124540 MSI2 http://www.ncbi.nlm.nih.gov/gene/?term=124540 MSI2H mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038383 124935 SLC43A2 http://www.ncbi.nlm.nih.gov/gene/?term=124935 LAT4 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038384 124935 SLC43A2 http://www.ncbi.nlm.nih.gov/gene/?term=124935 LAT4 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038385 124936 CYB5D2 http://www.ncbi.nlm.nih.gov/gene/?term=124936 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038386 124936 CYB5D2 http://www.ncbi.nlm.nih.gov/gene/?term=124936 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038387 124989 EFCAB13 http://www.ncbi.nlm.nih.gov/gene/?term=124989 C17orf57 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038388 125488 TTC39C http://www.ncbi.nlm.nih.gov/gene/?term=125488 "C18orf17, HsT2697" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038389 1271 CNTFR http://www.ncbi.nlm.nih.gov/gene/?term=1271 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038390 1271 CNTFR http://www.ncbi.nlm.nih.gov/gene/?term=1271 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038391 127294 MYOM3 http://www.ncbi.nlm.nih.gov/gene/?term=127294 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038392 127294 MYOM3 http://www.ncbi.nlm.nih.gov/gene/?term=127294 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038393 1281 COL3A1 http://www.ncbi.nlm.nih.gov/gene/?term=1281 EDS4A mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038394 1282 COL4A1 http://www.ncbi.nlm.nih.gov/gene/?term=1282 "BSVD, RATOR" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038395 1282 COL4A1 http://www.ncbi.nlm.nih.gov/gene/?term=1282 "BSVD, RATOR" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038396 128338 DRAM2 http://www.ncbi.nlm.nih.gov/gene/?term=128338 "CORD21, PRO180, TMEM77, WWFQ154" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038397 1284 COL4A2 http://www.ncbi.nlm.nih.gov/gene/?term=1284 "ICH, POREN2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038398 128553 TSHZ2 http://www.ncbi.nlm.nih.gov/gene/?term=128553 "C20orf17, OVC10-2, TSH2, ZABC2, ZNF218" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038399 128553 TSHZ2 http://www.ncbi.nlm.nih.gov/gene/?term=128553 "C20orf17, OVC10-2, TSH2, ZABC2, ZNF218" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038400 1287 COL4A5 http://www.ncbi.nlm.nih.gov/gene/?term=1287 "ASLN, ATS, CA54" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038401 1287 COL4A5 http://www.ncbi.nlm.nih.gov/gene/?term=1287 "ASLN, ATS, CA54" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038402 1288 COL4A6 http://www.ncbi.nlm.nih.gov/gene/?term=1288 "CXDELq22.3, DELXq22.3, DFNX6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038403 1288 COL4A6 http://www.ncbi.nlm.nih.gov/gene/?term=1288 "CXDELq22.3, DELXq22.3, DFNX6" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038404 128866 CHMP4B http://www.ncbi.nlm.nih.gov/gene/?term=128866 "C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038405 128869 PIGU http://www.ncbi.nlm.nih.gov/gene/?term=128869 "CDC91L1, GAB1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038406 128869 PIGU http://www.ncbi.nlm.nih.gov/gene/?term=128869 "CDC91L1, GAB1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038407 1289 COL5A1 http://www.ncbi.nlm.nih.gov/gene/?term=1289 EDSC mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038408 1289 COL5A1 http://www.ncbi.nlm.nih.gov/gene/?term=1289 EDSC mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038409 130074 FAM168B http://www.ncbi.nlm.nih.gov/gene/?term=130074 MANI mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038410 1303 COL12A1 http://www.ncbi.nlm.nih.gov/gene/?term=1303 "BA209D8.1, BTHLM2L, DJ234P15.1, UCMD2, COL12A1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038411 130872 AHSA2 http://www.ncbi.nlm.nih.gov/gene/?term=130872 "AHA1, Hch1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038412 130872 AHSA2 http://www.ncbi.nlm.nih.gov/gene/?term=130872 "AHA1, Hch1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038413 1312 COMT http://www.ncbi.nlm.nih.gov/gene/?term=1312 HEL-S-98n mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038414 1312 COMT http://www.ncbi.nlm.nih.gov/gene/?term=1312 HEL-S-98n mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038415 1315 COPB1 http://www.ncbi.nlm.nih.gov/gene/?term=1315 COPB mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038416 1317 SLC31A1 http://www.ncbi.nlm.nih.gov/gene/?term=1317 "COPT1, CTR1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038417 1317 SLC31A1 http://www.ncbi.nlm.nih.gov/gene/?term=1317 "COPT1, CTR1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038418 132 ADK http://www.ncbi.nlm.nih.gov/gene/?term=132 AK mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038419 132001 TAMM41 http://www.ncbi.nlm.nih.gov/gene/?term=132001 "C3orf31, RAM41, TAM41" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038420 132864 CPEB2 http://www.ncbi.nlm.nih.gov/gene/?term=132864 "CPE-BP2, CPEB-2, hCPEB-2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038421 133015 PACRGL http://www.ncbi.nlm.nih.gov/gene/?term=133015 C4orf28 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038422 133015 PACRGL http://www.ncbi.nlm.nih.gov/gene/?term=133015 C4orf28 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038423 134430 WDR36 http://www.ncbi.nlm.nih.gov/gene/?term=134430 "GLC1G, TA-WDRP, TAWDRP, UTP21" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038424 1345 COX6C http://www.ncbi.nlm.nih.gov/gene/?term=1345 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038425 1345 COX6C http://www.ncbi.nlm.nih.gov/gene/?term=1345 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038426 134957 STXBP5 http://www.ncbi.nlm.nih.gov/gene/?term=134957 "LGL3, LLGL3, Nbla04300" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038427 1353 COX11 http://www.ncbi.nlm.nih.gov/gene/?term=1353 COX11P mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038428 136 ADORA2B http://www.ncbi.nlm.nih.gov/gene/?term=136 ADORA2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038429 138241 C9orf85 http://www.ncbi.nlm.nih.gov/gene/?term=138241 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038430 138241 C9orf85 http://www.ncbi.nlm.nih.gov/gene/?term=138241 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038431 138428 PTRH1 http://www.ncbi.nlm.nih.gov/gene/?term=138428 "C9orf115, PTH1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038432 138428 PTRH1 http://www.ncbi.nlm.nih.gov/gene/?term=138428 "C9orf115, PTH1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038433 1387 CREBBP http://www.ncbi.nlm.nih.gov/gene/?term=1387 "CBP, KAT3A, RSTS, RSTS1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038434 1387 CREBBP http://www.ncbi.nlm.nih.gov/gene/?term=1387 "CBP, KAT3A, RSTS, RSTS1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038435 1398 CRK http://www.ncbi.nlm.nih.gov/gene/?term=1398 "CRKII, p38" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038436 1398 CRK http://www.ncbi.nlm.nih.gov/gene/?term=1398 "CRKII, p38" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038437 140609 NEK7 http://www.ncbi.nlm.nih.gov/gene/?term=140609 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038438 140609 NEK7 http://www.ncbi.nlm.nih.gov/gene/?term=140609 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038439 1408 CRY2 http://www.ncbi.nlm.nih.gov/gene/?term=1408 "HCRY2, PHLL2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038440 1408 CRY2 http://www.ncbi.nlm.nih.gov/gene/?term=1408 "HCRY2, PHLL2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038441 140885 SIRPA http://www.ncbi.nlm.nih.gov/gene/?term=140885 "BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038442 140885 SIRPA http://www.ncbi.nlm.nih.gov/gene/?term=140885 "BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038443 143187 VTI1A http://www.ncbi.nlm.nih.gov/gene/?term=143187 "MMDS3, MVti1, VTI1RP2, Vti1-rp2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038444 143187 VTI1A http://www.ncbi.nlm.nih.gov/gene/?term=143187 "MMDS3, MVti1, VTI1RP2, Vti1-rp2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038445 1432 MAPK14 http://www.ncbi.nlm.nih.gov/gene/?term=1432 "CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038446 1432 MAPK14 http://www.ncbi.nlm.nih.gov/gene/?term=1432 "CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038447 143458 LDLRAD3 http://www.ncbi.nlm.nih.gov/gene/?term=143458 LRAD3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038448 143458 LDLRAD3 http://www.ncbi.nlm.nih.gov/gene/?term=143458 LRAD3 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038449 143686 SESN3 http://www.ncbi.nlm.nih.gov/gene/?term=143686 SEST3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038450 143686 SESN3 http://www.ncbi.nlm.nih.gov/gene/?term=143686 SEST3 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038451 143879 KBTBD3 http://www.ncbi.nlm.nih.gov/gene/?term=143879 BKLHD3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038452 143879 KBTBD3 http://www.ncbi.nlm.nih.gov/gene/?term=143879 BKLHD3 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038453 144097 C11orf84 http://www.ncbi.nlm.nih.gov/gene/?term=144097 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038454 144108 SPTY2D1 http://www.ncbi.nlm.nih.gov/gene/?term=144108 Spt2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038455 144108 SPTY2D1 http://www.ncbi.nlm.nih.gov/gene/?term=144108 Spt2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038456 144402 CPNE8 http://www.ncbi.nlm.nih.gov/gene/?term=144402 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038457 1452 CSNK1A1 http://www.ncbi.nlm.nih.gov/gene/?term=1452 "CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038458 1452 CSNK1A1 http://www.ncbi.nlm.nih.gov/gene/?term=1452 "CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038459 1453 CSNK1D http://www.ncbi.nlm.nih.gov/gene/?term=1453 "ASPS, CKIdelta, FASPS2, HCKID" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038460 1453 CSNK1D http://www.ncbi.nlm.nih.gov/gene/?term=1453 "ASPS, CKIdelta, FASPS2, HCKID" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038461 145581 LRFN5 http://www.ncbi.nlm.nih.gov/gene/?term=145581 "C14orf146, FIGLER8, SALM5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038462 145581 LRFN5 http://www.ncbi.nlm.nih.gov/gene/?term=145581 "C14orf146, FIGLER8, SALM5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038463 145694 LOC145694 http://www.ncbi.nlm.nih.gov/gene/?term=145694 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00038464 145694 LOC145694 http://www.ncbi.nlm.nih.gov/gene/?term=145694 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00038465 1457 CSNK2A1 http://www.ncbi.nlm.nih.gov/gene/?term=1457 "CK2A1, CKII, CSNK2A3, Cka1, Cka2, OCNDS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038466 1486 CTBS http://www.ncbi.nlm.nih.gov/gene/?term=1486 CTB mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038467 1488 CTBP2 http://www.ncbi.nlm.nih.gov/gene/?term=1488 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038468 1488 CTBP2 http://www.ncbi.nlm.nih.gov/gene/?term=1488 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038469 149076 ZNF362 http://www.ncbi.nlm.nih.gov/gene/?term=149076 "RN, lin-29" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038470 1491 CTH http://www.ncbi.nlm.nih.gov/gene/?term=1491 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038471 1491 CTH http://www.ncbi.nlm.nih.gov/gene/?term=1491 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038472 1495 CTNNA1 http://www.ncbi.nlm.nih.gov/gene/?term=1495 "CAP102, MDPT2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038473 150709 ANKAR http://www.ncbi.nlm.nih.gov/gene/?term=150709 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038474 151188 ARL6IP6 http://www.ncbi.nlm.nih.gov/gene/?term=151188 "AIP-6, AIP6, PFAAP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038475 151195 CCNYL1 http://www.ncbi.nlm.nih.gov/gene/?term=151195 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038476 151195 CCNYL1 http://www.ncbi.nlm.nih.gov/gene/?term=151195 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038477 1512 CTSH http://www.ncbi.nlm.nih.gov/gene/?term=1512 "ACC-4, ACC-5, ACC4, ACC5, CPSB" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038478 1512 CTSH http://www.ncbi.nlm.nih.gov/gene/?term=1512 "ACC-4, ACC-5, ACC4, ACC5, CPSB" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038479 151963 MB21D2 http://www.ncbi.nlm.nih.gov/gene/?term=151963 C3orf59 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038480 151963 MB21D2 http://www.ncbi.nlm.nih.gov/gene/?term=151963 C3orf59 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038481 152002 XXYLT1 http://www.ncbi.nlm.nih.gov/gene/?term=152002 C3orf21 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038482 152006 RNF38 http://www.ncbi.nlm.nih.gov/gene/?term=152006 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038483 152100 CMC1 http://www.ncbi.nlm.nih.gov/gene/?term=152100 C3orf68 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038484 152185 SPICE1 http://www.ncbi.nlm.nih.gov/gene/?term=152185 "CCDC52, SPICE" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038485 152189 CMTM8 http://www.ncbi.nlm.nih.gov/gene/?term=152189 "CKLFSF8, CKLFSF8-V2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038486 152189 CMTM8 http://www.ncbi.nlm.nih.gov/gene/?term=152189 "CKLFSF8, CKLFSF8-V2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038487 1523 CUX1 http://www.ncbi.nlm.nih.gov/gene/?term=1523 "CASP, CDP, CDP/Cut, CDP1, COY1, CUTL1, CUX, Clox, Cux/CDP, GOLIM6, Nbla10317, p100, p110, p200, p75" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038488 1523 CUX1 http://www.ncbi.nlm.nih.gov/gene/?term=1523 "CASP, CDP, CDP/Cut, CDP1, COY1, CUTL1, CUX, Clox, Cux/CDP, GOLIM6, Nbla10317, p100, p110, p200, p75" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038489 152485 ZNF827 http://www.ncbi.nlm.nih.gov/gene/?term=152485 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038490 152485 ZNF827 http://www.ncbi.nlm.nih.gov/gene/?term=152485 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038491 152503 SH3D19 http://www.ncbi.nlm.nih.gov/gene/?term=152503 "EBP, EVE1, Eve-1, Kryn, SH3P19" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038492 152503 SH3D19 http://www.ncbi.nlm.nih.gov/gene/?term=152503 "EBP, EVE1, Eve-1, Kryn, SH3P19" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038493 152579 SCFD2 http://www.ncbi.nlm.nih.gov/gene/?term=152579 STXBP1L1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038494 152579 SCFD2 http://www.ncbi.nlm.nih.gov/gene/?term=152579 STXBP1L1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038495 152789 JAKMIP1 http://www.ncbi.nlm.nih.gov/gene/?term=152789 "Gababrbp, JAMIP1, MARLIN1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038496 152789 JAKMIP1 http://www.ncbi.nlm.nih.gov/gene/?term=152789 "Gababrbp, JAMIP1, MARLIN1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038497 153129 SLC38A9 http://www.ncbi.nlm.nih.gov/gene/?term=153129 URLC11 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038498 153241 CEP120 http://www.ncbi.nlm.nih.gov/gene/?term=153241 "CCDC100, SRTD13" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038499 153241 CEP120 http://www.ncbi.nlm.nih.gov/gene/?term=153241 "CCDC100, SRTD13" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038500 157570 ESCO2 http://www.ncbi.nlm.nih.gov/gene/?term=157570 "2410004I17Rik, EFO2, RBS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038501 157570 ESCO2 http://www.ncbi.nlm.nih.gov/gene/?term=157570 "2410004I17Rik, EFO2, RBS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038502 157680 VPS13B http://www.ncbi.nlm.nih.gov/gene/?term=157680 "CHS1, COH1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038503 157680 VPS13B http://www.ncbi.nlm.nih.gov/gene/?term=157680 "CHS1, COH1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038504 157922 CAMSAP1 http://www.ncbi.nlm.nih.gov/gene/?term=157922 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038505 158135 TTLL11 http://www.ncbi.nlm.nih.gov/gene/?term=158135 "C9orf20, bA244O19.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038506 158158 RASEF http://www.ncbi.nlm.nih.gov/gene/?term=158158 RAB45 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038507 158158 RASEF http://www.ncbi.nlm.nih.gov/gene/?term=158158 RAB45 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038508 158358 KIAA2026 http://www.ncbi.nlm.nih.gov/gene/?term=158358 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038509 158358 KIAA2026 http://www.ncbi.nlm.nih.gov/gene/?term=158358 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038510 158399 ZNF483 http://www.ncbi.nlm.nih.gov/gene/?term=158399 "ZKSCAN16, ZSCAN48" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038511 158399 ZNF483 http://www.ncbi.nlm.nih.gov/gene/?term=158399 "ZKSCAN16, ZSCAN48" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038512 158405 KIAA1958 http://www.ncbi.nlm.nih.gov/gene/?term=158405 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038513 1588 CYP19A1 http://www.ncbi.nlm.nih.gov/gene/?term=1588 "ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038514 1588 CYP19A1 http://www.ncbi.nlm.nih.gov/gene/?term=1588 "ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038515 159 ADSS http://www.ncbi.nlm.nih.gov/gene/?term=159 "ADEH 2, ADSS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038516 159 ADSS http://www.ncbi.nlm.nih.gov/gene/?term=159 "ADEH 2, ADSS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038517 1601 DAB2 http://www.ncbi.nlm.nih.gov/gene/?term=1601 "DOC-2, DOC2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038518 160335 TMTC2 http://www.ncbi.nlm.nih.gov/gene/?term=160335 IBDBP1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038519 160335 TMTC2 http://www.ncbi.nlm.nih.gov/gene/?term=160335 IBDBP1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038520 1604 CD55 http://www.ncbi.nlm.nih.gov/gene/?term=1604 "CHAPLE, CR, CROM, DAF, TC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038521 160518 DENND5B http://www.ncbi.nlm.nih.gov/gene/?term=160518 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038522 160518 DENND5B http://www.ncbi.nlm.nih.gov/gene/?term=160518 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038523 1612 DAPK1 http://www.ncbi.nlm.nih.gov/gene/?term=1612 "DAPK, ROCO3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038524 1612 DAPK1 http://www.ncbi.nlm.nih.gov/gene/?term=1612 "DAPK, ROCO3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038525 161742 SPRED1 http://www.ncbi.nlm.nih.gov/gene/?term=161742 "NFLS, PPP1R147, hSpred1, spred-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038526 162514 TRPV3 http://www.ncbi.nlm.nih.gov/gene/?term=162514 "FNEPPK2, OLMS, VRL3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038527 162514 TRPV3 http://www.ncbi.nlm.nih.gov/gene/?term=162514 "FNEPPK2, OLMS, VRL3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038528 163 AP2B1 http://www.ncbi.nlm.nih.gov/gene/?term=163 "ADTB2, AP105B, AP2-BETA, CLAPB1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038529 163115 ZNF781 http://www.ncbi.nlm.nih.gov/gene/?term=163115 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038530 1635 DCTD http://www.ncbi.nlm.nih.gov/gene/?term=1635 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038531 1635 DCTD http://www.ncbi.nlm.nih.gov/gene/?term=1635 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038532 163702 IFNLR1 http://www.ncbi.nlm.nih.gov/gene/?term=163702 "CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038533 1657 DMXL1 http://www.ncbi.nlm.nih.gov/gene/?term=1657 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038534 165918 RNF168 http://www.ncbi.nlm.nih.gov/gene/?term=165918 hRNF168 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038535 1660 DHX9 http://www.ncbi.nlm.nih.gov/gene/?term=1660 "DDX9, LKP, NDH2, NDHII, RHA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038536 1662 DDX10 http://www.ncbi.nlm.nih.gov/gene/?term=1662 "Dbp4, HRH-J8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038537 166614 DCLK2 http://www.ncbi.nlm.nih.gov/gene/?term=166614 "CL2, CLICK-II, CLICK2, CLIK2, DCAMKL2, DCDC3, DCDC3B, DCK2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038538 167153 PAPD4 http://www.ncbi.nlm.nih.gov/gene/?term=167153 "GLD2, TUT2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038539 170463 SSBP4 http://www.ncbi.nlm.nih.gov/gene/?term=170463 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038540 170463 SSBP4 http://www.ncbi.nlm.nih.gov/gene/?term=170463 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038541 171023 ASXL1 http://www.ncbi.nlm.nih.gov/gene/?term=171023 "BOPS, MDS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038542 1738 DLD http://www.ncbi.nlm.nih.gov/gene/?term=1738 "DLDDH, E3, GCSL, LAD, PHE3, DLD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038543 1738 DLD http://www.ncbi.nlm.nih.gov/gene/?term=1738 "DLDDH, E3, GCSL, LAD, PHE3, DLD" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038544 1739 DLG1 http://www.ncbi.nlm.nih.gov/gene/?term=1739 "DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038545 1760 DMPK http://www.ncbi.nlm.nih.gov/gene/?term=1760 "DM, DM1, DM1PK, DMK, MDPK, MT-PK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038546 1760 DMPK http://www.ncbi.nlm.nih.gov/gene/?term=1760 "DM, DM1, DM1PK, DMK, MDPK, MT-PK" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038547 1773 DNASE1 http://www.ncbi.nlm.nih.gov/gene/?term=1773 "DNL1, DRNI" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038548 1773 DNASE1 http://www.ncbi.nlm.nih.gov/gene/?term=1773 "DNL1, DRNI" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038549 1774 DNASE1L1 http://www.ncbi.nlm.nih.gov/gene/?term=1774 "DNAS1L1, DNASEX, DNL1L, G4.8, XIB" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038550 1774 DNASE1L1 http://www.ncbi.nlm.nih.gov/gene/?term=1774 "DNAS1L1, DNASEX, DNL1L, G4.8, XIB" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038551 1780 DYNC1I1 http://www.ncbi.nlm.nih.gov/gene/?term=1780 "DNCI1, DNCIC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038552 1780 DYNC1I1 http://www.ncbi.nlm.nih.gov/gene/?term=1780 "DNCI1, DNCIC1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038553 1781 DYNC1I2 http://www.ncbi.nlm.nih.gov/gene/?term=1781 "DIC74, DNCI2, IC2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038554 1785 DNM2 http://www.ncbi.nlm.nih.gov/gene/?term=1785 "CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, LCCS5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038555 1785 DNM2 http://www.ncbi.nlm.nih.gov/gene/?term=1785 "CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, LCCS5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038556 1788 DNMT3A http://www.ncbi.nlm.nih.gov/gene/?term=1788 "DNMT3A2, M.HsaIIIA, TBRS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038557 1788 DNMT3A http://www.ncbi.nlm.nih.gov/gene/?term=1788 "DNMT3A2, M.HsaIIIA, TBRS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038558 1809 DPYSL3 http://www.ncbi.nlm.nih.gov/gene/?term=1809 "CRMP-4, CRMP4, DRP-3, DRP3, LCRMP, ULIP, ULIP-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038559 1809 DPYSL3 http://www.ncbi.nlm.nih.gov/gene/?term=1809 "CRMP-4, CRMP4, DRP-3, DRP3, LCRMP, ULIP, ULIP-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038560 1827 RCAN1 http://www.ncbi.nlm.nih.gov/gene/?term=1827 "ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038561 1827 RCAN1 http://www.ncbi.nlm.nih.gov/gene/?term=1827 "ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038562 1847 DUSP5 http://www.ncbi.nlm.nih.gov/gene/?term=1847 "DUSP, HVH3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038563 1847 DUSP5 http://www.ncbi.nlm.nih.gov/gene/?term=1847 "DUSP, HVH3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038564 1859 DYRK1A http://www.ncbi.nlm.nih.gov/gene/?term=1859 "DYRK, DYRK1, HP86, MNB, MNBH, MRD7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038565 1859 DYRK1A http://www.ncbi.nlm.nih.gov/gene/?term=1859 "DYRK, DYRK1, HP86, MNB, MNBH, MRD7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038566 1870 E2F2 http://www.ncbi.nlm.nih.gov/gene/?term=1870 E2F-2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038567 1870 E2F2 http://www.ncbi.nlm.nih.gov/gene/?term=1870 E2F-2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038568 1879 EBF1 http://www.ncbi.nlm.nih.gov/gene/?term=1879 "COE1, EBF, O/E-1, OLF1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038569 1909 EDNRA http://www.ncbi.nlm.nih.gov/gene/?term=1909 "ET-A, ETA, ETA-R, ETAR, ETRA, MFDA, hET-AR" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038570 1912 PHC2 http://www.ncbi.nlm.nih.gov/gene/?term=1912 "EDR2, HPH2, PH2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038571 192669 AGO3 http://www.ncbi.nlm.nih.gov/gene/?term=192669 EIF2C3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038572 192669 AGO3 http://www.ncbi.nlm.nih.gov/gene/?term=192669 EIF2C3 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038573 192670 AGO4 http://www.ncbi.nlm.nih.gov/gene/?term=192670 EIF2C4 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038574 192670 AGO4 http://www.ncbi.nlm.nih.gov/gene/?term=192670 EIF2C4 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038575 1936 EEF1D http://www.ncbi.nlm.nih.gov/gene/?term=1936 "EF-1D, EF1D, FP1047" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038576 1936 EEF1D http://www.ncbi.nlm.nih.gov/gene/?term=1936 "EF-1D, EF1D, FP1047" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038577 1946 EFNA5 http://www.ncbi.nlm.nih.gov/gene/?term=1946 "AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038578 1946 EFNA5 http://www.ncbi.nlm.nih.gov/gene/?term=1946 "AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038579 1956 EGFR http://www.ncbi.nlm.nih.gov/gene/?term=1956 "ERBB, ERBB1, HER1, NISBD2, PIG61, mENA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038580 195828 ZNF367 http://www.ncbi.nlm.nih.gov/gene/?term=195828 "AFF29, CDC14B, ZFF29" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038581 195828 ZNF367 http://www.ncbi.nlm.nih.gov/gene/?term=195828 "AFF29, CDC14B, ZFF29" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038582 196074 METTL15 http://www.ncbi.nlm.nih.gov/gene/?term=196074 METT5D1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038583 196074 METTL15 http://www.ncbi.nlm.nih.gov/gene/?term=196074 METT5D1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038584 196294 IMMP1L http://www.ncbi.nlm.nih.gov/gene/?term=196294 "IMMP1, IMP1, IMP1-LIKE" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038585 196463 PLBD2 http://www.ncbi.nlm.nih.gov/gene/?term=196463 P76 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038586 196463 PLBD2 http://www.ncbi.nlm.nih.gov/gene/?term=196463 P76 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038587 196740 VSTM4 http://www.ncbi.nlm.nih.gov/gene/?term=196740 C10orf72 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038588 196740 VSTM4 http://www.ncbi.nlm.nih.gov/gene/?term=196740 C10orf72 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038589 196951 FAM227B http://www.ncbi.nlm.nih.gov/gene/?term=196951 C15orf33 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038590 197131 UBR1 http://www.ncbi.nlm.nih.gov/gene/?term=197131 JBS mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038591 197358 NLRC3 http://www.ncbi.nlm.nih.gov/gene/?term=197358 "CLR16.2, NOD3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038592 197358 NLRC3 http://www.ncbi.nlm.nih.gov/gene/?term=197358 "CLR16.2, NOD3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038593 1977 EIF4E http://www.ncbi.nlm.nih.gov/gene/?term=1977 "AUTS19, CBP1, EIF4EL1, EIF4F, eIF-4E, EIF4E" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038594 1977 EIF4E http://www.ncbi.nlm.nih.gov/gene/?term=1977 "AUTS19, CBP1, EIF4EL1, EIF4F, eIF-4E, EIF4E" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038595 1979 EIF4EBP2 http://www.ncbi.nlm.nih.gov/gene/?term=1979 "4EBP2, PHASII" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038596 1979 EIF4EBP2 http://www.ncbi.nlm.nih.gov/gene/?term=1979 "4EBP2, PHASII" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038597 1998 ELF2 http://www.ncbi.nlm.nih.gov/gene/?term=1998 "EU32, NERF, NERF-1A, NERF-1B, NERF-1a,b, NERF-2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038598 2004 ELK3 http://www.ncbi.nlm.nih.gov/gene/?term=2004 "ERP, NET, SAP-2, SAP2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038599 200734 SPRED2 http://www.ncbi.nlm.nih.gov/gene/?term=200734 Spred-2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038600 200895 DHFR2 http://www.ncbi.nlm.nih.gov/gene/?term=200895 "DHFRL1, DHFRP4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038601 200895 DHFR2 http://www.ncbi.nlm.nih.gov/gene/?term=200895 "DHFRL1, DHFRP4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038602 2009 EML1 http://www.ncbi.nlm.nih.gov/gene/?term=2009 "BH, ELP79, EMAP, EMAPL, HuEMAP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038603 2011 MARK2 http://www.ncbi.nlm.nih.gov/gene/?term=2011 "EMK-1, EMK1, PAR-1, Par-1b, Par1b" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038604 2011 MARK2 http://www.ncbi.nlm.nih.gov/gene/?term=2011 "EMK-1, EMK1, PAR-1, Par-1b, Par1b" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038605 201134 CEP112 http://www.ncbi.nlm.nih.gov/gene/?term=201134 "CCDC46, MACOCO" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038606 201134 CEP112 http://www.ncbi.nlm.nih.gov/gene/?term=201134 "CCDC46, MACOCO" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038607 201163 FLCN http://www.ncbi.nlm.nih.gov/gene/?term=201163 "BHD, FLCL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038608 201163 FLCN http://www.ncbi.nlm.nih.gov/gene/?term=201163 "BHD, FLCL" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038609 2012 EMP1 http://www.ncbi.nlm.nih.gov/gene/?term=2012 "CL-20, EMP-1, TMP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038610 201266 SLC39A11 http://www.ncbi.nlm.nih.gov/gene/?term=201266 "C17orf26, ZIP-11, ZIP11" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038611 201266 SLC39A11 http://www.ncbi.nlm.nih.gov/gene/?term=201266 "C17orf26, ZIP-11, ZIP11" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038612 201595 STT3B http://www.ncbi.nlm.nih.gov/gene/?term=201595 "CDG1X, SIMP, STT3-B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038613 201627 DENND6A http://www.ncbi.nlm.nih.gov/gene/?term=201627 "AFI1A, FAM116A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038614 2017 CTTN http://www.ncbi.nlm.nih.gov/gene/?term=2017 EMS1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038615 2017 CTTN http://www.ncbi.nlm.nih.gov/gene/?term=2017 EMS1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038616 202052 DNAJC18 http://www.ncbi.nlm.nih.gov/gene/?term=202052 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038617 202052 DNAJC18 http://www.ncbi.nlm.nih.gov/gene/?term=202052 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038618 202243 CCDC125 http://www.ncbi.nlm.nih.gov/gene/?term=202243 KENAE mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038619 203238 CCDC171 http://www.ncbi.nlm.nih.gov/gene/?term=203238 "C9orf93, bA536D16.1, bA778P13.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038620 203238 CCDC171 http://www.ncbi.nlm.nih.gov/gene/?term=203238 "C9orf93, bA536D16.1, bA778P13.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038621 2033 EP300 http://www.ncbi.nlm.nih.gov/gene/?term=2033 "KAT3B, RSTS2, p300" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038622 2033 EP300 http://www.ncbi.nlm.nih.gov/gene/?term=2033 "KAT3B, RSTS2, p300" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038623 2034 EPAS1 http://www.ncbi.nlm.nih.gov/gene/?term=2034 "ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038624 2034 EPAS1 http://www.ncbi.nlm.nih.gov/gene/?term=2034 "ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038625 2035 EPB41 http://www.ncbi.nlm.nih.gov/gene/?term=2035 "4.1R, EL1, HE" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038626 2035 EPB41 http://www.ncbi.nlm.nih.gov/gene/?term=2035 "4.1R, EL1, HE" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038627 2036 EPB41L1 http://www.ncbi.nlm.nih.gov/gene/?term=2036 "4.1N, MRD11" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038628 2038 EPB42 http://www.ncbi.nlm.nih.gov/gene/?term=2038 "PA, SPH5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038629 2038 EPB42 http://www.ncbi.nlm.nih.gov/gene/?term=2038 "PA, SPH5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038630 204 AK2 http://www.ncbi.nlm.nih.gov/gene/?term=204 ADK2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038631 204 AK2 http://www.ncbi.nlm.nih.gov/gene/?term=204 ADK2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038632 2043 EPHA4 http://www.ncbi.nlm.nih.gov/gene/?term=2043 "HEK8, SEK, TYRO1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038633 2044 EPHA5 http://www.ncbi.nlm.nih.gov/gene/?term=2044 "CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038634 2044 EPHA5 http://www.ncbi.nlm.nih.gov/gene/?term=2044 "CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038635 2048 EPHB2 http://www.ncbi.nlm.nih.gov/gene/?term=2048 "CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038636 2048 EPHB2 http://www.ncbi.nlm.nih.gov/gene/?term=2048 "CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038637 204962 SLC44A5 http://www.ncbi.nlm.nih.gov/gene/?term=204962 CTL5 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038638 205564 SENP5 http://www.ncbi.nlm.nih.gov/gene/?term=205564 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038639 2060 EPS15 http://www.ncbi.nlm.nih.gov/gene/?term=2060 "AF-1P, AF1P, MLLT5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038640 2066 ERBB4 http://www.ncbi.nlm.nih.gov/gene/?term=2066 "ALS19, HER4, p180erbB4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038641 2068 ERCC2 http://www.ncbi.nlm.nih.gov/gene/?term=2068 "COFS2, EM9, TFIIH, TTD, TTD1, XPD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038642 2068 ERCC2 http://www.ncbi.nlm.nih.gov/gene/?term=2068 "COFS2, EM9, TFIIH, TTD, TTD1, XPD" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038643 2078 ERG http://www.ncbi.nlm.nih.gov/gene/?term=2078 "erg-3, p55" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038644 2100 ESR2 http://www.ncbi.nlm.nih.gov/gene/?term=2100 "ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038645 2100 ESR2 http://www.ncbi.nlm.nih.gov/gene/?term=2100 "ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038646 2103 ESRRB http://www.ncbi.nlm.nih.gov/gene/?term=2103 "DFNB35, ERR2, ERRb, ESRL2, NR3B2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038647 2103 ESRRB http://www.ncbi.nlm.nih.gov/gene/?term=2103 "DFNB35, ERR2, ERRb, ESRL2, NR3B2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038648 2107 ETF1 http://www.ncbi.nlm.nih.gov/gene/?term=2107 "D5S1995, ERF, ERF1, RF1, SUP45L1, TB3-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038649 2108 ETFA http://www.ncbi.nlm.nih.gov/gene/?term=2108 "EMA, GA2, MADD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038650 2114 ETS2 http://www.ncbi.nlm.nih.gov/gene/?term=2114 ETS2IT1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038651 2120 ETV6 http://www.ncbi.nlm.nih.gov/gene/?term=2120 "TEL, TEL/ABL, THC5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038652 2120 ETV6 http://www.ncbi.nlm.nih.gov/gene/?term=2120 "TEL, TEL/ABL, THC5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038653 2121 EVC http://www.ncbi.nlm.nih.gov/gene/?term=2121 "DWF-11, EVCL, EVC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038654 2121 EVC http://www.ncbi.nlm.nih.gov/gene/?term=2121 "DWF-11, EVCL, EVC" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038655 2131 EXT1 http://www.ncbi.nlm.nih.gov/gene/?term=2131 "EXT, LGCR, LGS, TRPS2, TTV" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038656 2131 EXT1 http://www.ncbi.nlm.nih.gov/gene/?term=2131 "EXT, LGCR, LGS, TRPS2, TTV" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038657 2132 EXT2 http://www.ncbi.nlm.nih.gov/gene/?term=2132 "SOTV, SSMS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038658 2132 EXT2 http://www.ncbi.nlm.nih.gov/gene/?term=2132 "SOTV, SSMS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038659 214 ALCAM http://www.ncbi.nlm.nih.gov/gene/?term=214 "CD166, MEMD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038660 214 ALCAM http://www.ncbi.nlm.nih.gov/gene/?term=214 "CD166, MEMD" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038661 2140 EYA3 http://www.ncbi.nlm.nih.gov/gene/?term=2140 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038662 2146 EZH2 http://www.ncbi.nlm.nih.gov/gene/?term=2146 "ENX-1, ENX1b, KMT6, KMT6A, WVS, WVS2, EZH2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038663 2162 F13A1 http://www.ncbi.nlm.nih.gov/gene/?term=2162 F13A mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038664 2162 F13A1 http://www.ncbi.nlm.nih.gov/gene/?term=2162 F13A mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038665 2170 FABP3 http://www.ncbi.nlm.nih.gov/gene/?term=2170 "FABP11, H-FABP, M-FABP, MDGI, O-FABP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038666 2170 FABP3 http://www.ncbi.nlm.nih.gov/gene/?term=2170 "FABP11, H-FABP, M-FABP, MDGI, O-FABP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038667 2176 FANCC http://www.ncbi.nlm.nih.gov/gene/?term=2176 "FA3, FAC, FACC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038668 2180 ACSL1 http://www.ncbi.nlm.nih.gov/gene/?term=2180 "ACS1, FACL1, FACL2, LACS, LACS1, LACS2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038669 2180 ACSL1 http://www.ncbi.nlm.nih.gov/gene/?term=2180 "ACS1, FACL1, FACL2, LACS, LACS1, LACS2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038670 2186 BPTF http://www.ncbi.nlm.nih.gov/gene/?term=2186 "FAC1, FALZ, NURF301" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038671 219333 USP12 http://www.ncbi.nlm.nih.gov/gene/?term=219333 "UBH1L1, USP12" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038672 219333 USP12 http://www.ncbi.nlm.nih.gov/gene/?term=219333 "UBH1L1, USP12" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038673 2195 FAT1 http://www.ncbi.nlm.nih.gov/gene/?term=2195 "CDHF7, CDHR8, FAT, ME5, hFat1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038674 219771 CCNY http://www.ncbi.nlm.nih.gov/gene/?term=219771 "C10orf9, CBCP1, CCNX, CFP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038675 219771 CCNY http://www.ncbi.nlm.nih.gov/gene/?term=219771 "C10orf9, CBCP1, CCNX, CFP1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038676 220 ALDH1A3 http://www.ncbi.nlm.nih.gov/gene/?term=220 "ALDH1A6, ALDH6, MCOP8, RALDH3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038677 220 ALDH1A3 http://www.ncbi.nlm.nih.gov/gene/?term=220 "ALDH1A6, ALDH6, MCOP8, RALDH3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038678 2200 FBN1 http://www.ncbi.nlm.nih.gov/gene/?term=2200 "ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFLS, MFS1, OCTD, SGS, SSKS, WMS, WMS2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038679 2200 FBN1 http://www.ncbi.nlm.nih.gov/gene/?term=2200 "ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFLS, MFS1, OCTD, SGS, SSKS, WMS, WMS2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038680 220002 CYB561A3 http://www.ncbi.nlm.nih.gov/gene/?term=220002 "CYBASC3, LCYTB" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038681 220002 CYB561A3 http://www.ncbi.nlm.nih.gov/gene/?term=220002 "CYBASC3, LCYTB" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038682 2201 FBN2 http://www.ncbi.nlm.nih.gov/gene/?term=2201 "CCA, DA9, EOMD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038683 221035 REEP3 http://www.ncbi.nlm.nih.gov/gene/?term=221035 "C10orf74, Yip2b" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038684 221037 JMJD1C http://www.ncbi.nlm.nih.gov/gene/?term=221037 "KDM3C, TRIP-8, TRIP8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038685 221395 ADGRF5 http://www.ncbi.nlm.nih.gov/gene/?term=221395 "GPR116, KPG_001" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038686 221395 ADGRF5 http://www.ncbi.nlm.nih.gov/gene/?term=221395 "GPR116, KPG_001" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038687 221496 LEMD2 http://www.ncbi.nlm.nih.gov/gene/?term=221496 "CTRCT42, NET25, dJ482C21.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038688 221496 LEMD2 http://www.ncbi.nlm.nih.gov/gene/?term=221496 "CTRCT42, NET25, dJ482C21.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038689 221895 JAZF1 http://www.ncbi.nlm.nih.gov/gene/?term=221895 "TIP27, ZNF802" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038690 221895 JAZF1 http://www.ncbi.nlm.nih.gov/gene/?term=221895 "TIP27, ZNF802" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038691 2222 FDFT1 http://www.ncbi.nlm.nih.gov/gene/?term=2222 "DGPT, ERG9, SQS, SS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038692 222487 ADGRG3 http://www.ncbi.nlm.nih.gov/gene/?term=222487 "GPR97, PB99, PGR26" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038693 222487 ADGRG3 http://www.ncbi.nlm.nih.gov/gene/?term=222487 "GPR97, PB99, PGR26" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038694 222663 SCUBE3 http://www.ncbi.nlm.nih.gov/gene/?term=222663 CEGF3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038695 2241 FER http://www.ncbi.nlm.nih.gov/gene/?term=2241 "PPP1R74, TYK3, p94-Fer" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038696 2262 GPC5 http://www.ncbi.nlm.nih.gov/gene/?term=2262 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038697 2272 FHIT http://www.ncbi.nlm.nih.gov/gene/?term=2272 "AP3Aase, FRA3B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038698 2272 FHIT http://www.ncbi.nlm.nih.gov/gene/?term=2272 "AP3Aase, FRA3B" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038699 2274 FHL2 http://www.ncbi.nlm.nih.gov/gene/?term=2274 "AAG11, DRAL, FHL-2, SLIM-3, SLIM3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038700 2274 FHL2 http://www.ncbi.nlm.nih.gov/gene/?term=2274 "AAG11, DRAL, FHL-2, SLIM-3, SLIM3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038701 22800 RRAS2 http://www.ncbi.nlm.nih.gov/gene/?term=22800 TC21 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038702 22821 RASA3 http://www.ncbi.nlm.nih.gov/gene/?term=22821 "GAP1IP4BP, GAPIII" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038703 22828 SCAF8 http://www.ncbi.nlm.nih.gov/gene/?term=22828 RBM16 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038704 22828 SCAF8 http://www.ncbi.nlm.nih.gov/gene/?term=22828 RBM16 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038705 22834 ZNF652 http://www.ncbi.nlm.nih.gov/gene/?term=22834 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038706 22834 ZNF652 http://www.ncbi.nlm.nih.gov/gene/?term=22834 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038707 22836 RHOBTB3 http://www.ncbi.nlm.nih.gov/gene/?term=22836 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038708 22846 VASH1 http://www.ncbi.nlm.nih.gov/gene/?term=22846 KIAA1036 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038709 22859 ADGRL1 http://www.ncbi.nlm.nih.gov/gene/?term=22859 "CIRL1, CL1, LEC2, LPHN1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038710 22859 ADGRL1 http://www.ncbi.nlm.nih.gov/gene/?term=22859 "CIRL1, CL1, LEC2, LPHN1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038711 22862 FNDC3A http://www.ncbi.nlm.nih.gov/gene/?term=22862 "FNDC3, HUGO, bA203I16.1, bA203I16.5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038712 22862 FNDC3A http://www.ncbi.nlm.nih.gov/gene/?term=22862 "FNDC3, HUGO, bA203I16.1, bA203I16.5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038713 22864 R3HDM2 http://www.ncbi.nlm.nih.gov/gene/?term=22864 "CAG6, PR01365" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038714 22870 PPP6R1 http://www.ncbi.nlm.nih.gov/gene/?term=22870 "KIAA1115, PP6R1, SAP190, SAPS1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038715 22870 PPP6R1 http://www.ncbi.nlm.nih.gov/gene/?term=22870 "KIAA1115, PP6R1, SAP190, SAPS1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038716 22872 SEC31A http://www.ncbi.nlm.nih.gov/gene/?term=22872 "ABP125, ABP130, HSPC275, HSPC334, SEC31L1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038717 22872 SEC31A http://www.ncbi.nlm.nih.gov/gene/?term=22872 "ABP125, ABP130, HSPC275, HSPC334, SEC31L1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038718 22873 DZIP1 http://www.ncbi.nlm.nih.gov/gene/?term=22873 "DZIP, DZIPt1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038719 22876 INPP5F http://www.ncbi.nlm.nih.gov/gene/?term=22876 "MSTP007, MSTPO47, SAC2, hSAC2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038720 22876 INPP5F http://www.ncbi.nlm.nih.gov/gene/?term=22876 "MSTP007, MSTPO47, SAC2, hSAC2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038721 22882 ZHX2 http://www.ncbi.nlm.nih.gov/gene/?term=22882 "AFR1, RAF" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038722 22887 FOXJ3 http://www.ncbi.nlm.nih.gov/gene/?term=22887 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038723 22887 FOXJ3 http://www.ncbi.nlm.nih.gov/gene/?term=22887 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038724 22898 DENND3 http://www.ncbi.nlm.nih.gov/gene/?term=22898 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038725 22898 DENND3 http://www.ncbi.nlm.nih.gov/gene/?term=22898 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038726 22903 BTBD3 http://www.ncbi.nlm.nih.gov/gene/?term=22903 dJ742J24.1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038727 22905 EPN2 http://www.ncbi.nlm.nih.gov/gene/?term=22905 EHB21 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038728 22905 EPN2 http://www.ncbi.nlm.nih.gov/gene/?term=22905 EHB21 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038729 22909 FAN1 http://www.ncbi.nlm.nih.gov/gene/?term=22909 "KIAA1018, KMIN, MTMR15, hFAN1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038730 22909 FAN1 http://www.ncbi.nlm.nih.gov/gene/?term=22909 "KIAA1018, KMIN, MTMR15, hFAN1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038731 22913 RALY http://www.ncbi.nlm.nih.gov/gene/?term=22913 "HNRPCL2, P542" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038732 22913 RALY http://www.ncbi.nlm.nih.gov/gene/?term=22913 "HNRPCL2, P542" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038733 22920 KIFAP3 http://www.ncbi.nlm.nih.gov/gene/?term=22920 "FLA3, KAP-1, KAP-3, KAP3, SMAP, Smg-GDS, dJ190I16.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038734 22920 KIFAP3 http://www.ncbi.nlm.nih.gov/gene/?term=22920 "FLA3, KAP-1, KAP-3, KAP3, SMAP, Smg-GDS, dJ190I16.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038735 22926 ATF6 http://www.ncbi.nlm.nih.gov/gene/?term=22926 "ACHM7A, ATF6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038736 22926 ATF6 http://www.ncbi.nlm.nih.gov/gene/?term=22926 "ACHM7A, ATF6" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038737 22936 ELL2 http://www.ncbi.nlm.nih.gov/gene/?term=22936 MRCCAT1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038738 22948 CCT5 http://www.ncbi.nlm.nih.gov/gene/?term=22948 "CCT-epsilon, CCTE, HEL-S-69, PNAS-102, TCP-1-epsilon" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038739 22948 CCT5 http://www.ncbi.nlm.nih.gov/gene/?term=22948 "CCT-epsilon, CCTE, HEL-S-69, PNAS-102, TCP-1-epsilon" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038740 22978 NT5C2 http://www.ncbi.nlm.nih.gov/gene/?term=22978 "GMP, NT5B, PNT5, SPG45, SPG65, cN-II" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038741 22982 DIP2C http://www.ncbi.nlm.nih.gov/gene/?term=22982 KIAA0934 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038742 22982 DIP2C http://www.ncbi.nlm.nih.gov/gene/?term=22982 KIAA0934 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038743 22985 ACIN1 http://www.ncbi.nlm.nih.gov/gene/?term=22985 "ACINUS, ACN, fSAP152" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038744 22985 ACIN1 http://www.ncbi.nlm.nih.gov/gene/?term=22985 "ACINUS, ACN, fSAP152" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038745 22998 LIMCH1 http://www.ncbi.nlm.nih.gov/gene/?term=22998 "LIMCH1A, LMO7B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038746 22998 LIMCH1 http://www.ncbi.nlm.nih.gov/gene/?term=22998 "LIMCH1A, LMO7B" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038747 23005 MAPKBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23005 "JNKBP-1, JNKBP1, NPHP20" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038748 23011 RAB21 http://www.ncbi.nlm.nih.gov/gene/?term=23011 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038749 23022 PALLD http://www.ncbi.nlm.nih.gov/gene/?term=23022 "CGI-151, CGI151, MYN, PNCA1, SIH002" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038750 23022 PALLD http://www.ncbi.nlm.nih.gov/gene/?term=23022 "CGI-151, CGI151, MYN, PNCA1, SIH002" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038751 23023 TMCC1 http://www.ncbi.nlm.nih.gov/gene/?term=23023 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038752 23023 TMCC1 http://www.ncbi.nlm.nih.gov/gene/?term=23023 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038753 23024 PDZRN3 http://www.ncbi.nlm.nih.gov/gene/?term=23024 "LNX3, SEMACAP3, SEMCAP3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038754 23024 PDZRN3 http://www.ncbi.nlm.nih.gov/gene/?term=23024 "LNX3, SEMACAP3, SEMCAP3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038755 23032 USP33 http://www.ncbi.nlm.nih.gov/gene/?term=23032 VDU1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038756 23041 MON2 http://www.ncbi.nlm.nih.gov/gene/?term=23041 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038757 23043 TNIK http://www.ncbi.nlm.nih.gov/gene/?term=23043 MRT54 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038758 23043 TNIK http://www.ncbi.nlm.nih.gov/gene/?term=23043 MRT54 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038759 23048 FNBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23048 FBP17 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038760 23048 FNBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23048 FBP17 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038761 23049 SMG1 http://www.ncbi.nlm.nih.gov/gene/?term=23049 "61E3.4, ATX, LIP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038762 23054 NCOA6 http://www.ncbi.nlm.nih.gov/gene/?term=23054 "AIB3, ASC2, NRC, PRIP, RAP250, TRBP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038763 23054 NCOA6 http://www.ncbi.nlm.nih.gov/gene/?term=23054 "AIB3, ASC2, NRC, PRIP, RAP250, TRBP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038764 23063 WAPL http://www.ncbi.nlm.nih.gov/gene/?term=23063 "FOE, KIAA0261, WAPAL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038765 23063 WAPL http://www.ncbi.nlm.nih.gov/gene/?term=23063 "FOE, KIAA0261, WAPAL" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038766 23072 HECW1 http://www.ncbi.nlm.nih.gov/gene/?term=23072 NEDL1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038767 23072 HECW1 http://www.ncbi.nlm.nih.gov/gene/?term=23072 NEDL1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038768 23077 MYCBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23077 "Myc-bp2, PAM, Phr" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038769 23077 MYCBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23077 "Myc-bp2, PAM, Phr" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038770 23080 AVL9 http://www.ncbi.nlm.nih.gov/gene/?term=23080 KIAA0241 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038771 23081 KDM4C http://www.ncbi.nlm.nih.gov/gene/?term=23081 "GASC1, JHDM3C, JMJD2C, TDRD14C" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038772 23086 EXPH5 http://www.ncbi.nlm.nih.gov/gene/?term=23086 "SLAC2-B, SLAC2B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038773 23086 EXPH5 http://www.ncbi.nlm.nih.gov/gene/?term=23086 "SLAC2-B, SLAC2B" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038774 23092 ARHGAP26 http://www.ncbi.nlm.nih.gov/gene/?term=23092 "GRAF, GRAF1, OPHN1L, OPHN1L1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038775 23095 KIF1B http://www.ncbi.nlm.nih.gov/gene/?term=23095 "CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038776 23095 KIF1B http://www.ncbi.nlm.nih.gov/gene/?term=23095 "CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038777 23097 CDK19 http://www.ncbi.nlm.nih.gov/gene/?term=23097 "CDC2L6, CDK11, bA346C16.3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038778 23097 CDK19 http://www.ncbi.nlm.nih.gov/gene/?term=23097 "CDC2L6, CDK11, bA346C16.3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038779 23101 MCF2L2 http://www.ncbi.nlm.nih.gov/gene/?term=23101 ARHGEF22 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038780 23101 MCF2L2 http://www.ncbi.nlm.nih.gov/gene/?term=23101 ARHGEF22 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038781 23102 TBC1D2B http://www.ncbi.nlm.nih.gov/gene/?term=23102 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038782 23102 TBC1D2B http://www.ncbi.nlm.nih.gov/gene/?term=23102 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038783 23108 RAP1GAP2 http://www.ncbi.nlm.nih.gov/gene/?term=23108 "GARNL4, RAP1GA3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038784 23108 RAP1GAP2 http://www.ncbi.nlm.nih.gov/gene/?term=23108 "GARNL4, RAP1GA3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038785 23111 SPART http://www.ncbi.nlm.nih.gov/gene/?term=23111 "SPG20, TAHCCP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038786 23111 SPART http://www.ncbi.nlm.nih.gov/gene/?term=23111 "SPG20, TAHCCP1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038787 23118 TAB2 http://www.ncbi.nlm.nih.gov/gene/?term=23118 "CHTD2, MAP3K7IP2, TAB-2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038788 23126 POGZ http://www.ncbi.nlm.nih.gov/gene/?term=23126 "MRD37, WHSUS, ZNF280E, ZNF635, ZNF635m" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038789 23126 POGZ http://www.ncbi.nlm.nih.gov/gene/?term=23126 "MRD37, WHSUS, ZNF280E, ZNF635, ZNF635m" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038790 23131 GPATCH8 http://www.ncbi.nlm.nih.gov/gene/?term=23131 "GPATC8, KIAA0553" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038791 23131 GPATCH8 http://www.ncbi.nlm.nih.gov/gene/?term=23131 "GPATC8, KIAA0553" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038792 23142 DCUN1D4 http://www.ncbi.nlm.nih.gov/gene/?term=23142 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038793 23142 DCUN1D4 http://www.ncbi.nlm.nih.gov/gene/?term=23142 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038794 23143 LRCH1 http://www.ncbi.nlm.nih.gov/gene/?term=23143 "CHDC1, NP81" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038795 23143 LRCH1 http://www.ncbi.nlm.nih.gov/gene/?term=23143 "CHDC1, NP81" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038796 23144 ZC3H3 http://www.ncbi.nlm.nih.gov/gene/?term=23144 ZC3HDC3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038797 23155 CLCC1 http://www.ncbi.nlm.nih.gov/gene/?term=23155 MCLC mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038798 23155 CLCC1 http://www.ncbi.nlm.nih.gov/gene/?term=23155 MCLC mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038799 23161 SNX13 http://www.ncbi.nlm.nih.gov/gene/?term=23161 RGS-PX1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038800 23168 RTF1 http://www.ncbi.nlm.nih.gov/gene/?term=23168 "GTL7, KIAA0252" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038801 23172 ABRAXAS2 http://www.ncbi.nlm.nih.gov/gene/?term=23172 "ABRO1, FAM175B, KIAA0157" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038802 23174 ZCCHC14 http://www.ncbi.nlm.nih.gov/gene/?term=23174 "BDG-29, BDG29" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038803 23174 ZCCHC14 http://www.ncbi.nlm.nih.gov/gene/?term=23174 "BDG-29, BDG29" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038804 23177 CEP68 http://www.ncbi.nlm.nih.gov/gene/?term=23177 KIAA0582 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038805 23177 CEP68 http://www.ncbi.nlm.nih.gov/gene/?term=23177 KIAA0582 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038806 23178 PASK http://www.ncbi.nlm.nih.gov/gene/?term=23178 "PASKIN, STK37" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038807 23178 PASK http://www.ncbi.nlm.nih.gov/gene/?term=23178 "PASKIN, STK37" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038808 23180 RFTN1 http://www.ncbi.nlm.nih.gov/gene/?term=23180 "MIG2, PIB10, PIG9, RAFTLIN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038809 23180 RFTN1 http://www.ncbi.nlm.nih.gov/gene/?term=23180 "MIG2, PIB10, PIG9, RAFTLIN" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038810 23185 LARP4B http://www.ncbi.nlm.nih.gov/gene/?term=23185 "KIAA0217, LARP5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038811 23185 LARP4B http://www.ncbi.nlm.nih.gov/gene/?term=23185 "KIAA0217, LARP5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038812 23187 PHLDB1 http://www.ncbi.nlm.nih.gov/gene/?term=23187 LL5A mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038813 23187 PHLDB1 http://www.ncbi.nlm.nih.gov/gene/?term=23187 LL5A mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038814 23195 MDN1 http://www.ncbi.nlm.nih.gov/gene/?term=23195 Rea1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038815 23195 MDN1 http://www.ncbi.nlm.nih.gov/gene/?term=23195 Rea1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038816 23196 FAM120A http://www.ncbi.nlm.nih.gov/gene/?term=23196 "C9orf10, HBVPTPAP, OSSA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038817 23196 FAM120A http://www.ncbi.nlm.nih.gov/gene/?term=23196 "C9orf10, HBVPTPAP, OSSA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038818 23198 PSME4 http://www.ncbi.nlm.nih.gov/gene/?term=23198 PA200 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038819 23198 PSME4 http://www.ncbi.nlm.nih.gov/gene/?term=23198 PA200 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038820 23199 GSE1 http://www.ncbi.nlm.nih.gov/gene/?term=23199 "CRHSP24, KIAA0182" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038821 23199 GSE1 http://www.ncbi.nlm.nih.gov/gene/?term=23199 "CRHSP24, KIAA0182" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038822 23213 SULF1 http://www.ncbi.nlm.nih.gov/gene/?term=23213 SULF-1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038823 23213 SULF1 http://www.ncbi.nlm.nih.gov/gene/?term=23213 SULF-1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038824 23214 XPO6 http://www.ncbi.nlm.nih.gov/gene/?term=23214 "EXP6, RANBP20" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038825 23214 XPO6 http://www.ncbi.nlm.nih.gov/gene/?term=23214 "EXP6, RANBP20" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038826 23216 TBC1D1 http://www.ncbi.nlm.nih.gov/gene/?term=23216 "TBC, TBC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038827 23216 TBC1D1 http://www.ncbi.nlm.nih.gov/gene/?term=23216 "TBC, TBC1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038828 23224 SYNE2 http://www.ncbi.nlm.nih.gov/gene/?term=23224 "EDMD5, KASH2, NUA, NUANCE, Nesp2, Nesprin-2, SYNE-2, TROPH" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038829 23230 VPS13A http://www.ncbi.nlm.nih.gov/gene/?term=23230 "CHAC, CHOREIN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038830 23230 VPS13A http://www.ncbi.nlm.nih.gov/gene/?term=23230 "CHAC, CHOREIN" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038831 23231 SEL1L3 http://www.ncbi.nlm.nih.gov/gene/?term=23231 Sel-1L3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038832 23231 SEL1L3 http://www.ncbi.nlm.nih.gov/gene/?term=23231 Sel-1L3 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038833 23236 PLCB1 http://www.ncbi.nlm.nih.gov/gene/?term=23236 "EIEE12, PI-PLC, PLC-154, PLC-I, PLC-beta-1, PLC154A, PLCB1B, PLCB1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038834 23236 PLCB1 http://www.ncbi.nlm.nih.gov/gene/?term=23236 "EIEE12, PI-PLC, PLC-154, PLC-I, PLC-beta-1, PLC154A, PLCB1B, PLCB1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038835 23240 TMEM131L http://www.ncbi.nlm.nih.gov/gene/?term=23240 KIAA0922 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038836 23240 TMEM131L http://www.ncbi.nlm.nih.gov/gene/?term=23240 KIAA0922 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038837 23242 COBL http://www.ncbi.nlm.nih.gov/gene/?term=23242 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038838 23244 PDS5A http://www.ncbi.nlm.nih.gov/gene/?term=23244 "PIG54, SCC-112, SCC112" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038839 23244 PDS5A http://www.ncbi.nlm.nih.gov/gene/?term=23244 "PIG54, SCC-112, SCC112" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038840 23247 KIAA0556 http://www.ncbi.nlm.nih.gov/gene/?term=23247 JBTS26 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038841 23247 KIAA0556 http://www.ncbi.nlm.nih.gov/gene/?term=23247 JBTS26 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038842 23248 RPRD2 http://www.ncbi.nlm.nih.gov/gene/?term=23248 "HSPC099, KIAA0460" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038843 23248 RPRD2 http://www.ncbi.nlm.nih.gov/gene/?term=23248 "HSPC099, KIAA0460" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038844 23250 ATP11A http://www.ncbi.nlm.nih.gov/gene/?term=23250 "ATPIH, ATPIS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038845 23250 ATP11A http://www.ncbi.nlm.nih.gov/gene/?term=23250 "ATPIH, ATPIS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038846 23253 ANKRD12 http://www.ncbi.nlm.nih.gov/gene/?term=23253 "ANCO-2, ANCO1, GAC-1, Nbla00144" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038847 23255 MTCL1 http://www.ncbi.nlm.nih.gov/gene/?term=23255 "CCDC165, KIAA0802, SOGA2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038848 23255 MTCL1 http://www.ncbi.nlm.nih.gov/gene/?term=23255 "CCDC165, KIAA0802, SOGA2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038849 23256 SCFD1 http://www.ncbi.nlm.nih.gov/gene/?term=23256 "C14orf163, RA410, SLY1, SLY1P, STXBP1L2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038850 23256 SCFD1 http://www.ncbi.nlm.nih.gov/gene/?term=23256 "C14orf163, RA410, SLY1, SLY1P, STXBP1L2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038851 23261 CAMTA1 http://www.ncbi.nlm.nih.gov/gene/?term=23261 CANPMR mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038852 23261 CAMTA1 http://www.ncbi.nlm.nih.gov/gene/?term=23261 CANPMR mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038853 23263 MCF2L http://www.ncbi.nlm.nih.gov/gene/?term=23263 "ARHGEF14, DBS, OST" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038854 23263 MCF2L http://www.ncbi.nlm.nih.gov/gene/?term=23263 "ARHGEF14, DBS, OST" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038855 23272 FAM208A http://www.ncbi.nlm.nih.gov/gene/?term=23272 "C3orf63, RAP140, TASOR, se89-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038856 23275 POFUT2 http://www.ncbi.nlm.nih.gov/gene/?term=23275 "C21orf80, FUT13" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038857 23275 POFUT2 http://www.ncbi.nlm.nih.gov/gene/?term=23275 "C21orf80, FUT13" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038858 23276 KLHL18 http://www.ncbi.nlm.nih.gov/gene/?term=23276 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038859 23279 NUP160 http://www.ncbi.nlm.nih.gov/gene/?term=23279 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038860 23286 WWC1 http://www.ncbi.nlm.nih.gov/gene/?term=23286 "HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038861 23286 WWC1 http://www.ncbi.nlm.nih.gov/gene/?term=23286 "HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038862 23291 FBXW11 http://www.ncbi.nlm.nih.gov/gene/?term=23291 "BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038863 23291 FBXW11 http://www.ncbi.nlm.nih.gov/gene/?term=23291 "BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038864 23294 ANKS1A http://www.ncbi.nlm.nih.gov/gene/?term=23294 ANKS1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038865 23294 ANKS1A http://www.ncbi.nlm.nih.gov/gene/?term=23294 ANKS1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038866 23301 EHBP1 http://www.ncbi.nlm.nih.gov/gene/?term=23301 "HPC12, NACSIN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038867 23304 UBR2 http://www.ncbi.nlm.nih.gov/gene/?term=23304 "C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038868 23304 UBR2 http://www.ncbi.nlm.nih.gov/gene/?term=23304 "C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038869 23315 SLC9A8 http://www.ncbi.nlm.nih.gov/gene/?term=23315 "NHE-8, NHE8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038870 23315 SLC9A8 http://www.ncbi.nlm.nih.gov/gene/?term=23315 "NHE-8, NHE8" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038871 23328 SASH1 http://www.ncbi.nlm.nih.gov/gene/?term=23328 "SH3D6A, dJ323M4.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038872 23332 CLASP1 http://www.ncbi.nlm.nih.gov/gene/?term=23332 MAST1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038873 23332 CLASP1 http://www.ncbi.nlm.nih.gov/gene/?term=23332 MAST1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038874 23339 VPS39 http://www.ncbi.nlm.nih.gov/gene/?term=23339 "TLP, VAM6, hVam6p" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038875 23345 SYNE1 http://www.ncbi.nlm.nih.gov/gene/?term=23345 "8B, ARCA1, C6orf98, CPG2, EDMD4, KASH1, MYNE1, Nesp1, SCAR8, dJ45H2.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038876 23352 UBR4 http://www.ncbi.nlm.nih.gov/gene/?term=23352 "RBAF600, ZUBR1, p600" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038877 23362 PSD3 http://www.ncbi.nlm.nih.gov/gene/?term=23362 "EFA6D, EFA6R, HCA67" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038878 23362 PSD3 http://www.ncbi.nlm.nih.gov/gene/?term=23362 "EFA6D, EFA6R, HCA67" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038879 23369 PUM2 http://www.ncbi.nlm.nih.gov/gene/?term=23369 "PUMH2, PUML2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038880 23386 NUDCD3 http://www.ncbi.nlm.nih.gov/gene/?term=23386 NudCL mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038881 23386 NUDCD3 http://www.ncbi.nlm.nih.gov/gene/?term=23386 NudCL mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038882 23387 SIK3 http://www.ncbi.nlm.nih.gov/gene/?term=23387 "L19, QSK, SIK-3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038883 23389 MED13L http://www.ncbi.nlm.nih.gov/gene/?term=23389 "MRFACD, PROSIT240, THRAP2, TRAP240L" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038884 23389 MED13L http://www.ncbi.nlm.nih.gov/gene/?term=23389 "MRFACD, PROSIT240, THRAP2, TRAP240L" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038885 23394 ADNP http://www.ncbi.nlm.nih.gov/gene/?term=23394 "ADNP1, HVDAS, MRD28" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038886 23394 ADNP http://www.ncbi.nlm.nih.gov/gene/?term=23394 "ADNP1, HVDAS, MRD28" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038887 23403 FBXO46 http://www.ncbi.nlm.nih.gov/gene/?term=23403 "20D7-FC4, FBXO34L, Fbx46" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038888 23406 COTL1 http://www.ncbi.nlm.nih.gov/gene/?term=23406 CLP mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038889 23406 COTL1 http://www.ncbi.nlm.nih.gov/gene/?term=23406 CLP mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038890 23431 AP4E1 http://www.ncbi.nlm.nih.gov/gene/?term=23431 "CPSQ4, SPG51, STUT1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038891 23438 HARS2 http://www.ncbi.nlm.nih.gov/gene/?term=23438 "HARSL, HARSR, HO3, PRLTS2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038892 23446 SLC44A1 http://www.ncbi.nlm.nih.gov/gene/?term=23446 "CD92, CDW92, CHTL1, CTL1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038893 23446 SLC44A1 http://www.ncbi.nlm.nih.gov/gene/?term=23446 "CD92, CDW92, CHTL1, CTL1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038894 23468 CBX5 http://www.ncbi.nlm.nih.gov/gene/?term=23468 "HEL25, HP1, HP1A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038895 23468 CBX5 http://www.ncbi.nlm.nih.gov/gene/?term=23468 "HEL25, HP1, HP1A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038896 23473 CAPN7 http://www.ncbi.nlm.nih.gov/gene/?term=23473 "CALPAIN7, PALBH" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038897 23473 CAPN7 http://www.ncbi.nlm.nih.gov/gene/?term=23473 "CALPAIN7, PALBH" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038898 23478 SEC11A http://www.ncbi.nlm.nih.gov/gene/?term=23478 "1810012E07Rik, SEC11L1, SPC18, SPCS4A, sid2895" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038899 23484 LEPROTL1 http://www.ncbi.nlm.nih.gov/gene/?term=23484 "HSPC112, Vps55, my047" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038900 23499 MACF1 http://www.ncbi.nlm.nih.gov/gene/?term=23499 "ABP620, ACF7, MACF, OFC4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038901 23499 MACF1 http://www.ncbi.nlm.nih.gov/gene/?term=23499 "ABP620, ACF7, MACF, OFC4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038902 23515 MORC3 http://www.ncbi.nlm.nih.gov/gene/?term=23515 "NXP2, ZCW5, ZCWCC3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038903 23515 MORC3 http://www.ncbi.nlm.nih.gov/gene/?term=23515 "NXP2, ZCW5, ZCWCC3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038904 23517 SKIV2L2 http://www.ncbi.nlm.nih.gov/gene/?term=23517 "Dob1, KIAA0052, Mtr4, fSAP118" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038905 23518 R3HDM1 http://www.ncbi.nlm.nih.gov/gene/?term=23518 R3HDM mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038906 23518 R3HDM1 http://www.ncbi.nlm.nih.gov/gene/?term=23518 R3HDM mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038907 23522 KAT6B http://www.ncbi.nlm.nih.gov/gene/?term=23522 "GTPTS, MORF, MOZ2, MYST4, ZC2HC6B, qkf, querkopf" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038908 23522 KAT6B http://www.ncbi.nlm.nih.gov/gene/?term=23522 "GTPTS, MORF, MOZ2, MYST4, ZC2HC6B, qkf, querkopf" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038909 23524 SRRM2 http://www.ncbi.nlm.nih.gov/gene/?term=23524 "300-KD, CWF21, Cwc21, HSPC075, SRL300, SRm300" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038910 23527 ACAP2 http://www.ncbi.nlm.nih.gov/gene/?term=23527 "CENTB2, CNT-B2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038911 23527 ACAP2 http://www.ncbi.nlm.nih.gov/gene/?term=23527 "CENTB2, CNT-B2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038912 23530 NNT http://www.ncbi.nlm.nih.gov/gene/?term=23530 GCCD4 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038913 23530 NNT http://www.ncbi.nlm.nih.gov/gene/?term=23530 GCCD4 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038914 23543 RBFOX2 http://www.ncbi.nlm.nih.gov/gene/?term=23543 "FOX2, Fox-2, HNRBP2, HRNBP2, RBM9, RTA, dJ106I20.3, fxh" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038915 23543 RBFOX2 http://www.ncbi.nlm.nih.gov/gene/?term=23543 "FOX2, Fox-2, HNRBP2, HRNBP2, RBM9, RTA, dJ106I20.3, fxh" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038916 23576 DDAH1 http://www.ncbi.nlm.nih.gov/gene/?term=23576 "DDAH, DDAH-1, DDAHI, HEL-S-16" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038917 23576 DDAH1 http://www.ncbi.nlm.nih.gov/gene/?term=23576 "DDAH, DDAH-1, DDAHI, HEL-S-16" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038918 23593 HEBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23593 "C6ORF34B, C6orf34, PP23, SOUL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038919 23597 ACOT9 http://www.ncbi.nlm.nih.gov/gene/?term=23597 "ACATE2, CGI-16, MT-ACT48, MTACT48" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038920 23597 ACOT9 http://www.ncbi.nlm.nih.gov/gene/?term=23597 "ACATE2, CGI-16, MT-ACT48, MTACT48" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038921 23608 MKRN1 http://www.ncbi.nlm.nih.gov/gene/?term=23608 RNF61 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038922 23613 ZMYND8 http://www.ncbi.nlm.nih.gov/gene/?term=23613 "PRKCBP1, PRO2893, RACK7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038923 23613 ZMYND8 http://www.ncbi.nlm.nih.gov/gene/?term=23613 "PRKCBP1, PRO2893, RACK7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038924 23633 KPNA6 http://www.ncbi.nlm.nih.gov/gene/?term=23633 "IPOA7, KPNA7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038925 23633 KPNA6 http://www.ncbi.nlm.nih.gov/gene/?term=23633 "IPOA7, KPNA7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038926 23643 LY96 http://www.ncbi.nlm.nih.gov/gene/?term=23643 "ESOP-1, MD-2, MD2, ly-96" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038927 23643 LY96 http://www.ncbi.nlm.nih.gov/gene/?term=23643 "ESOP-1, MD-2, MD2, ly-96" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038928 23648 SSBP3 http://www.ncbi.nlm.nih.gov/gene/?term=23648 "CSDP, SSDP, SSDP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038929 23648 SSBP3 http://www.ncbi.nlm.nih.gov/gene/?term=23648 "CSDP, SSDP, SSDP1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038930 23657 SLC7A11 http://www.ncbi.nlm.nih.gov/gene/?term=23657 "CCBR1, xCT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038931 23657 SLC7A11 http://www.ncbi.nlm.nih.gov/gene/?term=23657 "CCBR1, xCT" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038932 23673 STX12 http://www.ncbi.nlm.nih.gov/gene/?term=23673 "STX13, STX14" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038933 23683 PRKD3 http://www.ncbi.nlm.nih.gov/gene/?term=23683 "EPK2, PKC-NU, PKD3, PRKCN, nPKC-NU" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038934 23705 CADM1 http://www.ncbi.nlm.nih.gov/gene/?term=23705 "BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, SYNCAM, TSLC1, sTSLC-1, sgIGSF, synCAM1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038935 23731 TMEM245 http://www.ncbi.nlm.nih.gov/gene/?term=23731 "C9orf5, CG-2, CG2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038936 23731 TMEM245 http://www.ncbi.nlm.nih.gov/gene/?term=23731 "C9orf5, CG-2, CG2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038937 23762 OSBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23762 "HLM, ORP-4, ORP4, OSBPL1, OSBPL4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038938 23762 OSBP2 http://www.ncbi.nlm.nih.gov/gene/?term=23762 "HLM, ORP-4, ORP4, OSBPL1, OSBPL4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038939 23780 APOL2 http://www.ncbi.nlm.nih.gov/gene/?term=23780 "APOL-II, APOL3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038940 23780 APOL2 http://www.ncbi.nlm.nih.gov/gene/?term=23780 "APOL-II, APOL3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038941 23786 BCL2L13 http://www.ncbi.nlm.nih.gov/gene/?term=23786 "BCL-RAMBO, Bcl2-L-13, MIL1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038942 23786 BCL2L13 http://www.ncbi.nlm.nih.gov/gene/?term=23786 "BCL-RAMBO, Bcl2-L-13, MIL1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038943 23788 MTCH2 http://www.ncbi.nlm.nih.gov/gene/?term=23788 "HSPC032, MIMP, SLC25A50" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038944 23788 MTCH2 http://www.ncbi.nlm.nih.gov/gene/?term=23788 "HSPC032, MIMP, SLC25A50" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038945 238 ALK http://www.ncbi.nlm.nih.gov/gene/?term=238 "CD246, NBLST3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038946 238 ALK http://www.ncbi.nlm.nih.gov/gene/?term=238 "CD246, NBLST3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038947 240 ALOX5 http://www.ncbi.nlm.nih.gov/gene/?term=240 "5-LO, 5-LOX, 5LPG, LOG5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038948 240 ALOX5 http://www.ncbi.nlm.nih.gov/gene/?term=240 "5-LO, 5-LOX, 5LPG, LOG5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038949 249 ALPL http://www.ncbi.nlm.nih.gov/gene/?term=249 "AP-TNAP, APTNAP, HOPS, TNAP, TNSALP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038950 249 ALPL http://www.ncbi.nlm.nih.gov/gene/?term=249 "AP-TNAP, APTNAP, HOPS, TNAP, TNSALP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038951 2495 FTH1 http://www.ncbi.nlm.nih.gov/gene/?term=2495 "FHC, FTH, FTHL6, HFE5, PIG15, PLIF" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038952 2495 FTH1 http://www.ncbi.nlm.nih.gov/gene/?term=2495 "FHC, FTH, FTHL6, HFE5, PIG15, PLIF" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038953 25 ABL1 http://www.ncbi.nlm.nih.gov/gene/?term=25 "ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038954 25 ABL1 http://www.ncbi.nlm.nih.gov/gene/?term=25 "ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038955 2534 FYN http://www.ncbi.nlm.nih.gov/gene/?term=2534 "SLK, SYN, p59-FYN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038956 253430 IPMK http://www.ncbi.nlm.nih.gov/gene/?term=253430 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038957 253559 CADM2 http://www.ncbi.nlm.nih.gov/gene/?term=253559 "IGSF4D, NECL3, Necl-3, SynCAM 2, synCAM2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038958 253769 WDR27 http://www.ncbi.nlm.nih.gov/gene/?term=253769 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038959 253769 WDR27 http://www.ncbi.nlm.nih.gov/gene/?term=253769 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038960 253782 CERS6 http://www.ncbi.nlm.nih.gov/gene/?term=253782 "CERS5, LASS6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038961 253827 MSRB3 http://www.ncbi.nlm.nih.gov/gene/?term=253827 DFNB74 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038962 253827 MSRB3 http://www.ncbi.nlm.nih.gov/gene/?term=253827 DFNB74 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038963 253959 RALGAPA1 http://www.ncbi.nlm.nih.gov/gene/?term=253959 "GARNL1, GRIPE, RalGAPalpha1, TULIP1, p240" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038964 253980 KCTD13 http://www.ncbi.nlm.nih.gov/gene/?term=253980 "BACURD1, FKSG86, PDIP1, POLDIP1, hBACURD1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038965 253980 KCTD13 http://www.ncbi.nlm.nih.gov/gene/?term=253980 "BACURD1, FKSG86, PDIP1, POLDIP1, hBACURD1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038966 255967 PAN3 http://www.ncbi.nlm.nih.gov/gene/?term=255967 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038967 2568 GABRP http://www.ncbi.nlm.nih.gov/gene/?term=2568 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038968 2568 GABRP http://www.ncbi.nlm.nih.gov/gene/?term=2568 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038969 256949 KANK3 http://www.ncbi.nlm.nih.gov/gene/?term=256949 ANKRD47 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038970 257397 TAB3 http://www.ncbi.nlm.nih.gov/gene/?term=257397 "MAP3K7IP3, NAP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038971 25771 TBC1D22A http://www.ncbi.nlm.nih.gov/gene/?term=25771 "C22orf4, HSC79E021" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038972 25771 TBC1D22A http://www.ncbi.nlm.nih.gov/gene/?term=25771 "C22orf4, HSC79E021" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038973 25809 TTLL1 http://www.ncbi.nlm.nih.gov/gene/?term=25809 "C22orf7, HS323M22B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038974 25809 TTLL1 http://www.ncbi.nlm.nih.gov/gene/?term=25809 "C22orf7, HS323M22B" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038975 25814 ATXN10 http://www.ncbi.nlm.nih.gov/gene/?term=25814 "E46L, HUMEEP, SCA10" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038976 25814 ATXN10 http://www.ncbi.nlm.nih.gov/gene/?term=25814 "E46L, HUMEEP, SCA10" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038977 25816 TNFAIP8 http://www.ncbi.nlm.nih.gov/gene/?term=25816 "GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038978 25816 TNFAIP8 http://www.ncbi.nlm.nih.gov/gene/?term=25816 "GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038979 25820 ARIH1 http://www.ncbi.nlm.nih.gov/gene/?term=25820 "ARI, HARI, HHARI, UBCH7BP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038980 25825 BACE2 http://www.ncbi.nlm.nih.gov/gene/?term=25825 "AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038981 25825 BACE2 http://www.ncbi.nlm.nih.gov/gene/?term=25825 "AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038982 25829 TMEM184B http://www.ncbi.nlm.nih.gov/gene/?term=25829 "C22orf5, FM08, HS5O6A, HSPC256" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038983 25829 TMEM184B http://www.ncbi.nlm.nih.gov/gene/?term=25829 "C22orf5, FM08, HS5O6A, HSPC256" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038984 25831 HECTD1 http://www.ncbi.nlm.nih.gov/gene/?term=25831 EULIR mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038985 25831 HECTD1 http://www.ncbi.nlm.nih.gov/gene/?term=25831 EULIR mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038986 25836 NIPBL http://www.ncbi.nlm.nih.gov/gene/?term=25836 "CDLS, CDLS1, IDN3, IDN3-B, Scc2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038987 2585 GALK2 http://www.ncbi.nlm.nih.gov/gene/?term=2585 GK2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038988 25862 USP49 http://www.ncbi.nlm.nih.gov/gene/?term=25862 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038989 25884 CHRDL2 http://www.ncbi.nlm.nih.gov/gene/?term=25884 "BNF1, CHL2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038990 25884 CHRDL2 http://www.ncbi.nlm.nih.gov/gene/?term=25884 "BNF1, CHL2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038991 25885 POLR1A http://www.ncbi.nlm.nih.gov/gene/?term=25885 "A190, RPA1, RPO14, AFDCIN, RPA194, RPO1-4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038992 25885 POLR1A http://www.ncbi.nlm.nih.gov/gene/?term=25885 "A190, RPA1, RPO14, AFDCIN, RPA194, RPO1-4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038993 25896 INTS7 http://www.ncbi.nlm.nih.gov/gene/?term=25896 "C1orf73, INT7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038994 25896 INTS7 http://www.ncbi.nlm.nih.gov/gene/?term=25896 "C1orf73, INT7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038995 2590 GALNT2 http://www.ncbi.nlm.nih.gov/gene/?term=2590 GalNAc-T2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038996 2590 GALNT2 http://www.ncbi.nlm.nih.gov/gene/?term=2590 GalNAc-T2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038997 25911 DPCD http://www.ncbi.nlm.nih.gov/gene/?term=25911 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00038998 25911 DPCD http://www.ncbi.nlm.nih.gov/gene/?term=25911 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00038999 25920 NELFB http://www.ncbi.nlm.nih.gov/gene/?term=25920 "COBRA1, NELF-B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039000 25920 NELFB http://www.ncbi.nlm.nih.gov/gene/?term=25920 "COBRA1, NELF-B" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039001 259230 SGMS1 http://www.ncbi.nlm.nih.gov/gene/?term=259230 "MOB, MOB1, SMS1, TMEM23, hmob33" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039002 259230 SGMS1 http://www.ncbi.nlm.nih.gov/gene/?term=259230 "MOB, MOB1, SMS1, TMEM23, hmob33" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039003 25925 ZNF521 http://www.ncbi.nlm.nih.gov/gene/?term=25925 "EHZF, Evi3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039004 25925 ZNF521 http://www.ncbi.nlm.nih.gov/gene/?term=25925 "EHZF, Evi3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039005 259266 ASPM http://www.ncbi.nlm.nih.gov/gene/?term=259266 "ASP, Calmbp1, MCPH5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039006 25929 GEMIN5 http://www.ncbi.nlm.nih.gov/gene/?term=25929 GEMIN-5 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039007 25929 GEMIN5 http://www.ncbi.nlm.nih.gov/gene/?term=25929 GEMIN-5 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039008 25932 CLIC4 http://www.ncbi.nlm.nih.gov/gene/?term=25932 "CLIC4L, H1, MTCLIC, huH1, p64H1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039009 25932 CLIC4 http://www.ncbi.nlm.nih.gov/gene/?term=25932 "CLIC4L, H1, MTCLIC, huH1, p64H1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039010 25936 NSL1 http://www.ncbi.nlm.nih.gov/gene/?term=25936 "C1orf48, DC8, MIS14" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039011 25936 NSL1 http://www.ncbi.nlm.nih.gov/gene/?term=25936 "C1orf48, DC8, MIS14" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039012 25948 KBTBD2 http://www.ncbi.nlm.nih.gov/gene/?term=25948 BKLHD1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039013 25948 KBTBD2 http://www.ncbi.nlm.nih.gov/gene/?term=25948 BKLHD1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039014 25959 KANK2 http://www.ncbi.nlm.nih.gov/gene/?term=25959 "ANKRD25, MXRA3, PPKWH, SIP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039015 25959 KANK2 http://www.ncbi.nlm.nih.gov/gene/?term=25959 "ANKRD25, MXRA3, PPKWH, SIP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039016 25961 NUDT13 http://www.ncbi.nlm.nih.gov/gene/?term=25961 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039017 25961 NUDT13 http://www.ncbi.nlm.nih.gov/gene/?term=25961 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039018 25966 C2CD2 http://www.ncbi.nlm.nih.gov/gene/?term=25966 "C21orf25, C21orf258, TMEM24L" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039019 25966 C2CD2 http://www.ncbi.nlm.nih.gov/gene/?term=25966 "C21orf25, C21orf258, TMEM24L" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039020 25984 KRT23 http://www.ncbi.nlm.nih.gov/gene/?term=25984 "CK23, HAIK1, K23" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039021 25984 KRT23 http://www.ncbi.nlm.nih.gov/gene/?term=25984 "CK23, HAIK1, K23" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039022 25999 CLIP3 http://www.ncbi.nlm.nih.gov/gene/?term=25999 "CLIPR-59, CLIPR59, RSNL1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039023 25999 CLIP3 http://www.ncbi.nlm.nih.gov/gene/?term=25999 "CLIPR-59, CLIPR59, RSNL1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039024 26002 MOXD1 http://www.ncbi.nlm.nih.gov/gene/?term=26002 "MOX, PRO5780, dJ248E1.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039025 26003 GORASP2 http://www.ncbi.nlm.nih.gov/gene/?term=26003 "GOLPH6, GRASP55, GRS2, p59" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039026 26003 GORASP2 http://www.ncbi.nlm.nih.gov/gene/?term=26003 "GOLPH6, GRASP55, GRS2, p59" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039027 26005 C2CD3 http://www.ncbi.nlm.nih.gov/gene/?term=26005 OFD14 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039028 26010 SPATS2L http://www.ncbi.nlm.nih.gov/gene/?term=26010 "DNAPTP6, SGNP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039029 26013 L3MBTL1 http://www.ncbi.nlm.nih.gov/gene/?term=26013 "H-L(3)MBT, L3MBTL, ZC2HC3, dJ138B7.3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039030 26019 UPF2 http://www.ncbi.nlm.nih.gov/gene/?term=26019 "HUPF2, RENT2, smg-3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039031 26019 UPF2 http://www.ncbi.nlm.nih.gov/gene/?term=26019 "HUPF2, RENT2, smg-3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039032 26031 OSBPL3 http://www.ncbi.nlm.nih.gov/gene/?term=26031 "ORP-3, ORP3, OSBP3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039033 26031 OSBPL3 http://www.ncbi.nlm.nih.gov/gene/?term=26031 "ORP-3, ORP3, OSBP3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039034 260425 MAGI3 http://www.ncbi.nlm.nih.gov/gene/?term=260425 "MAGI-3, dJ730K3.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039035 26047 CNTNAP2 http://www.ncbi.nlm.nih.gov/gene/?term=26047 "AUTS15, CASPR2, CDFE, NRXN4, PTHSL1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039036 26047 CNTNAP2 http://www.ncbi.nlm.nih.gov/gene/?term=26047 "AUTS15, CASPR2, CDFE, NRXN4, PTHSL1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039037 26053 AUTS2 http://www.ncbi.nlm.nih.gov/gene/?term=26053 "FBRSL2, MRD26" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039038 26053 AUTS2 http://www.ncbi.nlm.nih.gov/gene/?term=26053 "FBRSL2, MRD26" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039039 26054 SENP6 http://www.ncbi.nlm.nih.gov/gene/?term=26054 "SSP1, SUSP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039040 26057 ANKRD17 http://www.ncbi.nlm.nih.gov/gene/?term=26057 "GTAR, MASK2, NY-BR-16" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039041 26057 ANKRD17 http://www.ncbi.nlm.nih.gov/gene/?term=26057 "GTAR, MASK2, NY-BR-16" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039042 26058 GIGYF2 http://www.ncbi.nlm.nih.gov/gene/?term=26058 "GYF2, PARK11, PERQ2, PERQ3, TNRC15" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039043 26058 GIGYF2 http://www.ncbi.nlm.nih.gov/gene/?term=26058 "GYF2, PARK11, PERQ2, PERQ3, TNRC15" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039044 26059 ERC2 http://www.ncbi.nlm.nih.gov/gene/?term=26059 "CAST, CAST1, ELKSL, SPBC110, Spc110" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039045 26059 ERC2 http://www.ncbi.nlm.nih.gov/gene/?term=26059 "CAST, CAST1, ELKSL, SPBC110, Spc110" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039046 26064 RAI14 http://www.ncbi.nlm.nih.gov/gene/?term=26064 "NORPEG, RAI13" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039047 26065 LSM14A http://www.ncbi.nlm.nih.gov/gene/?term=26065 "C19orf13, FAM61A, RAP55, RAP55A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039048 26065 LSM14A http://www.ncbi.nlm.nih.gov/gene/?term=26065 "C19orf13, FAM61A, RAP55, RAP55A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039049 26091 HERC4 http://www.ncbi.nlm.nih.gov/gene/?term=26091 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039050 26091 HERC4 http://www.ncbi.nlm.nih.gov/gene/?term=26091 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039051 26133 TRPC4AP http://www.ncbi.nlm.nih.gov/gene/?term=26133 "C20orf188, PPP1R158, TRRP4AP, TRUSS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039052 26137 ZBTB20 http://www.ncbi.nlm.nih.gov/gene/?term=26137 "DPZF, HOF, ODA-8S, PRIMS, ZNF288" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039053 26137 ZBTB20 http://www.ncbi.nlm.nih.gov/gene/?term=26137 "DPZF, HOF, ODA-8S, PRIMS, ZNF288" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039054 26146 TRAF3IP1 http://www.ncbi.nlm.nih.gov/gene/?term=26146 "IFT54, MIP-T3, MIPT3, SLSN9" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039055 26164 MTG2 http://www.ncbi.nlm.nih.gov/gene/?term=26164 "GTPBP5, ObgH1, dJ1005F21.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039056 26164 MTG2 http://www.ncbi.nlm.nih.gov/gene/?term=26164 "GTPBP5, ObgH1, dJ1005F21.2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039057 26205 GMEB2 http://www.ncbi.nlm.nih.gov/gene/?term=26205 "GMEB-2, P79PIF, PIF79" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039058 26205 GMEB2 http://www.ncbi.nlm.nih.gov/gene/?term=26205 "GMEB-2, P79PIF, PIF79" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039059 26207 PITPNC1 http://www.ncbi.nlm.nih.gov/gene/?term=26207 "M-RDGB-beta, MRDGBbeta, RDGB-BETA, RDGBB, RDGBB1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039060 26207 PITPNC1 http://www.ncbi.nlm.nih.gov/gene/?term=26207 "M-RDGB-beta, MRDGBbeta, RDGB-BETA, RDGBB, RDGBB1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039061 2621 GAS6 http://www.ncbi.nlm.nih.gov/gene/?term=2621 "AXLLG, AXSF" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039062 2621 GAS6 http://www.ncbi.nlm.nih.gov/gene/?term=2621 "AXLLG, AXSF" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039063 26229 B3GAT3 http://www.ncbi.nlm.nih.gov/gene/?term=26229 "GLCATI, JDSCD, glcUAT-I" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039064 26229 B3GAT3 http://www.ncbi.nlm.nih.gov/gene/?term=26229 "GLCATI, JDSCD, glcUAT-I" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039065 26235 FBXL4 http://www.ncbi.nlm.nih.gov/gene/?term=26235 "FBL4, FBL5, MTDPS13" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039066 26256 CABYR http://www.ncbi.nlm.nih.gov/gene/?term=26256 "CABYRac, CABYRc/d, CABYRe, CBP86, CT88, FSP-2, FSP2, CABYR" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039067 26256 CABYR http://www.ncbi.nlm.nih.gov/gene/?term=26256 "CABYRac, CABYRc/d, CABYRe, CBP86, CT88, FSP-2, FSP2, CABYR" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039068 26259 FBXW8 http://www.ncbi.nlm.nih.gov/gene/?term=26259 "FBW6, FBW8, FBX29, FBXO29, FBXW6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039069 26259 FBXW8 http://www.ncbi.nlm.nih.gov/gene/?term=26259 "FBW6, FBW8, FBX29, FBXO29, FBXW6" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039070 26268 FBXO9 http://www.ncbi.nlm.nih.gov/gene/?term=26268 "FBX9, NY-REN-57, VCIA1, dJ341E18.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039071 2627 GATA6 http://www.ncbi.nlm.nih.gov/gene/?term=2627 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039072 26275 HIBCH http://www.ncbi.nlm.nih.gov/gene/?term=26275 HIBYLCOAH mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039073 26276 VPS33B http://www.ncbi.nlm.nih.gov/gene/?term=26276 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039074 26276 VPS33B http://www.ncbi.nlm.nih.gov/gene/?term=26276 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039075 26289 AK5 http://www.ncbi.nlm.nih.gov/gene/?term=26289 AK6 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039076 26289 AK5 http://www.ncbi.nlm.nih.gov/gene/?term=26289 AK6 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039077 26297 SERGEF http://www.ncbi.nlm.nih.gov/gene/?term=26297 "DELGEF, Gnefr" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039078 26297 SERGEF http://www.ncbi.nlm.nih.gov/gene/?term=26297 "DELGEF, Gnefr" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039079 26505 CNNM3 http://www.ncbi.nlm.nih.gov/gene/?term=26505 ACDP3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039080 26505 CNNM3 http://www.ncbi.nlm.nih.gov/gene/?term=26505 ACDP3 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039081 2651 GCNT2 http://www.ncbi.nlm.nih.gov/gene/?term=2651 "CCAT, CTRCT13C, GCNT5, IGNT, II, NACGT1, NAGCT1, ULG3, bA360O19.2, bA421M1.1, GCNT2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039082 2651 GCNT2 http://www.ncbi.nlm.nih.gov/gene/?term=2651 "CCAT, CTRCT13C, GCNT5, IGNT, II, NACGT1, NAGCT1, ULG3, bA360O19.2, bA421M1.1, GCNT2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039083 26512 INTS6 http://www.ncbi.nlm.nih.gov/gene/?term=26512 "DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039084 26524 LATS2 http://www.ncbi.nlm.nih.gov/gene/?term=26524 KPM mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039085 2661 GDF9 http://www.ncbi.nlm.nih.gov/gene/?term=2661 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039086 2661 GDF9 http://www.ncbi.nlm.nih.gov/gene/?term=2661 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039087 26610 ELP4 http://www.ncbi.nlm.nih.gov/gene/?term=26610 "AN, AN2, C11orf19, PAX6NEB, PAXNEB, dJ68P15A.1, hELP4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039088 26610 ELP4 http://www.ncbi.nlm.nih.gov/gene/?term=26610 "AN, AN2, C11orf19, PAX6NEB, PAXNEB, dJ68P15A.1, hELP4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039089 2669 GEM http://www.ncbi.nlm.nih.gov/gene/?term=2669 KIR mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039090 2669 GEM http://www.ncbi.nlm.nih.gov/gene/?term=2669 KIR mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039091 26750 RPS6KC1 http://www.ncbi.nlm.nih.gov/gene/?term=26750 "RPK118, RSKL1, S6K-delta-1, S6PKh1, humS6PKh1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039092 26750 RPS6KC1 http://www.ncbi.nlm.nih.gov/gene/?term=26750 "RPK118, RSKL1, S6K-delta-1, S6PKh1, humS6PKh1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039093 26751 SH3YL1 http://www.ncbi.nlm.nih.gov/gene/?term=26751 RAY mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039094 26751 SH3YL1 http://www.ncbi.nlm.nih.gov/gene/?term=26751 RAY mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039095 2683 B4GALT1 http://www.ncbi.nlm.nih.gov/gene/?term=2683 "B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039096 26960 NBEA http://www.ncbi.nlm.nih.gov/gene/?term=26960 "BCL8B, LYST2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039097 26984 SEC22A http://www.ncbi.nlm.nih.gov/gene/?term=26984 SEC22L2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039098 26986 PABPC1 http://www.ncbi.nlm.nih.gov/gene/?term=26986 "PAB1, PABP, PABP1, PABPC2, PABPL1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039099 26986 PABPC1 http://www.ncbi.nlm.nih.gov/gene/?term=26986 "PAB1, PABP, PABP1, PABPC2, PABPL1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039100 27020 NPTN http://www.ncbi.nlm.nih.gov/gene/?term=27020 "GP55, GP65, SDFR1, SDR1, np55, np65" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039101 27020 NPTN http://www.ncbi.nlm.nih.gov/gene/?term=27020 "GP55, GP65, SDFR1, SDR1, np55, np65" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039102 27032 ATP2C1 http://www.ncbi.nlm.nih.gov/gene/?term=27032 "ATP2C1A, BCPM, HHD, PMR1, SPCA1, hSPCA1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039103 27044 SND1 http://www.ncbi.nlm.nih.gov/gene/?term=27044 "TDRD11, Tudor-SN, p100" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039104 27044 SND1 http://www.ncbi.nlm.nih.gov/gene/?term=27044 "TDRD11, Tudor-SN, p100" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039105 27067 STAU2 http://www.ncbi.nlm.nih.gov/gene/?term=27067 "39K2, 39K3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039106 27067 STAU2 http://www.ncbi.nlm.nih.gov/gene/?term=27067 "39K2, 39K3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039107 27068 PPA2 http://www.ncbi.nlm.nih.gov/gene/?term=27068 "HSPC124, SCFAI, SCFI, SID6-306" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039108 27068 PPA2 http://www.ncbi.nlm.nih.gov/gene/?term=27068 "HSPC124, SCFAI, SCFI, SID6-306" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039109 27086 FOXP1 http://www.ncbi.nlm.nih.gov/gene/?term=27086 "12CC4, HSPC215, MFH, QRF1, hFKH1B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039110 27086 FOXP1 http://www.ncbi.nlm.nih.gov/gene/?term=27086 "12CC4, HSPC215, MFH, QRF1, hFKH1B" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039111 27132 CPNE7 http://www.ncbi.nlm.nih.gov/gene/?term=27132 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039112 27132 CPNE7 http://www.ncbi.nlm.nih.gov/gene/?term=27132 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039113 27136 MORC1 http://www.ncbi.nlm.nih.gov/gene/?term=27136 "CT33, MORC, ZCW6" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039114 27183 VPS4A http://www.ncbi.nlm.nih.gov/gene/?term=27183 "SKD1, SKD1A, SKD2, VPS4, VPS4-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039115 27183 VPS4A http://www.ncbi.nlm.nih.gov/gene/?term=27183 "SKD1, SKD1A, SKD2, VPS4, VPS4-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039116 27230 SERP1 http://www.ncbi.nlm.nih.gov/gene/?term=27230 RAMP4 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039117 27230 SERP1 http://www.ncbi.nlm.nih.gov/gene/?term=27230 RAMP4 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039118 27246 RNF115 http://www.ncbi.nlm.nih.gov/gene/?term=27246 "BCA2, ZNF364" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039119 27246 RNF115 http://www.ncbi.nlm.nih.gov/gene/?term=27246 "BCA2, ZNF364" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039120 27250 PDCD4 http://www.ncbi.nlm.nih.gov/gene/?term=27250 H731 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039121 27303 RBMS3 http://www.ncbi.nlm.nih.gov/gene/?term=27303 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039122 27303 RBMS3 http://www.ncbi.nlm.nih.gov/gene/?term=27303 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039123 27327 TNRC6A http://www.ncbi.nlm.nih.gov/gene/?term=27327 "CAGH26, GW1, GW182, TNRC6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039124 27332 ZNF638 http://www.ncbi.nlm.nih.gov/gene/?term=27332 "NP220, ZFML, Zfp638" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039125 27332 ZNF638 http://www.ncbi.nlm.nih.gov/gene/?term=27332 "NP220, ZFML, Zfp638" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039126 2734 GLG1 http://www.ncbi.nlm.nih.gov/gene/?term=2734 "CFR-1, ESL-1, MG-160, MG160" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039127 2734 GLG1 http://www.ncbi.nlm.nih.gov/gene/?term=2734 "CFR-1, ESL-1, MG-160, MG160" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039128 27347 STK39 http://www.ncbi.nlm.nih.gov/gene/?term=27347 "DCHT, PASK, SPAK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039129 27347 STK39 http://www.ncbi.nlm.nih.gov/gene/?term=27347 "DCHT, PASK, SPAK" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039130 2736 GLI2 http://www.ncbi.nlm.nih.gov/gene/?term=2736 "CJS, HPE9, PHS2, THP1, THP2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039131 2736 GLI2 http://www.ncbi.nlm.nih.gov/gene/?term=2736 "CJS, HPE9, PHS2, THP1, THP2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039132 27436 EML4 http://www.ncbi.nlm.nih.gov/gene/?term=27436 "C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039133 27436 EML4 http://www.ncbi.nlm.nih.gov/gene/?term=27436 "C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039134 2744 GLS http://www.ncbi.nlm.nih.gov/gene/?term=2744 "AAD20, GAC, GAM1, KGA, GLS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039135 2744 GLS http://www.ncbi.nlm.nih.gov/gene/?term=2744 "AAD20, GAC, GAM1, KGA, GLS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039136 2760 GM2A http://www.ncbi.nlm.nih.gov/gene/?term=2760 "GM2-AP, SAP-3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039137 2760 GM2A http://www.ncbi.nlm.nih.gov/gene/?term=2760 "GM2-AP, SAP-3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039138 2762 GMDS http://www.ncbi.nlm.nih.gov/gene/?term=2762 "GMD, SDR3E1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039139 2762 GMDS http://www.ncbi.nlm.nih.gov/gene/?term=2762 "GMD, SDR3E1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039140 2768 GNA12 http://www.ncbi.nlm.nih.gov/gene/?term=2768 "NNX3, RMP, gep" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039141 2768 GNA12 http://www.ncbi.nlm.nih.gov/gene/?term=2768 "NNX3, RMP, gep" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039142 2771 GNAI2 http://www.ncbi.nlm.nih.gov/gene/?term=2771 "GIPB, H_LUCA15.1, H_LUCA16.1, GNAI2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039143 2776 GNAQ http://www.ncbi.nlm.nih.gov/gene/?term=2776 "CMC1, G-ALPHA-q, GAQ, SWS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039144 2782 GNB1 http://www.ncbi.nlm.nih.gov/gene/?term=2782 MRD42 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039145 2782 GNB1 http://www.ncbi.nlm.nih.gov/gene/?term=2782 MRD42 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039146 2820 GPD2 http://www.ncbi.nlm.nih.gov/gene/?term=2820 "GDH2, GPDM, mGPDH" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039147 2820 GPD2 http://www.ncbi.nlm.nih.gov/gene/?term=2820 "GDH2, GPDM, mGPDH" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039148 28232 SLCO3A1 http://www.ncbi.nlm.nih.gov/gene/?term=28232 "OATP-D, OATP-RP3, OATP3A1, OATPD, OATPRP3, SLC21A11" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039149 28232 SLCO3A1 http://www.ncbi.nlm.nih.gov/gene/?term=28232 "OATP-D, OATP-RP3, OATP3A1, OATPD, OATPRP3, SLC21A11" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039150 283450 HECTD4 http://www.ncbi.nlm.nih.gov/gene/?term=283450 "C12orf51, POTAGE" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039151 283450 HECTD4 http://www.ncbi.nlm.nih.gov/gene/?term=283450 "C12orf51, POTAGE" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039152 283459 GATC http://www.ncbi.nlm.nih.gov/gene/?term=283459 15E1.2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039153 283459 GATC http://www.ncbi.nlm.nih.gov/gene/?term=283459 15E1.2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039154 283635 FAM177A1 http://www.ncbi.nlm.nih.gov/gene/?term=283635 C14orf24 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039155 283635 FAM177A1 http://www.ncbi.nlm.nih.gov/gene/?term=283635 C14orf24 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039156 283807 FBXL22 http://www.ncbi.nlm.nih.gov/gene/?term=283807 Fbl22 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039157 283807 FBXL22 http://www.ncbi.nlm.nih.gov/gene/?term=283807 Fbl22 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039158 284001 CCDC57 http://www.ncbi.nlm.nih.gov/gene/?term=284001 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039159 284001 CCDC57 http://www.ncbi.nlm.nih.gov/gene/?term=284001 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039160 284004 HEXDC http://www.ncbi.nlm.nih.gov/gene/?term=284004 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039161 284004 HEXDC http://www.ncbi.nlm.nih.gov/gene/?term=284004 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039162 284119 CAVIN1 http://www.ncbi.nlm.nih.gov/gene/?term=284119 "CAVIN, CGL4, FKSG13, PTRF, cavin-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039163 284119 CAVIN1 http://www.ncbi.nlm.nih.gov/gene/?term=284119 "CAVIN, CGL4, FKSG13, PTRF, cavin-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039164 284273 ZADH2 http://www.ncbi.nlm.nih.gov/gene/?term=284273 PRG-3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039165 284521 OR2L13 http://www.ncbi.nlm.nih.gov/gene/?term=284521 OR2L14 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039166 284521 OR2L13 http://www.ncbi.nlm.nih.gov/gene/?term=284521 OR2L14 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039167 284618 RUSC1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=284618 C1orf104 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00039168 284618 RUSC1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=284618 C1orf104 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00039169 284996 RNF149 http://www.ncbi.nlm.nih.gov/gene/?term=284996 DNAPTP2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039170 284996 RNF149 http://www.ncbi.nlm.nih.gov/gene/?term=284996 DNAPTP2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039171 285 ANGPT2 http://www.ncbi.nlm.nih.gov/gene/?term=285 "AGPT2, ANG2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039172 285148 IAH1 http://www.ncbi.nlm.nih.gov/gene/?term=285148 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039173 285362 SUMF1 http://www.ncbi.nlm.nih.gov/gene/?term=285362 "AAPA3037, FGE, UNQ3037" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039174 285362 SUMF1 http://www.ncbi.nlm.nih.gov/gene/?term=285362 "AAPA3037, FGE, UNQ3037" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039175 285513 GPRIN3 http://www.ncbi.nlm.nih.gov/gene/?term=285513 GRIN3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039176 285943 HOXA-AS2 http://www.ncbi.nlm.nih.gov/gene/?term=285943 HOXA3as lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00039177 285943 HOXA-AS2 http://www.ncbi.nlm.nih.gov/gene/?term=285943 HOXA3as lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00039178 286053 NSMCE2 http://www.ncbi.nlm.nih.gov/gene/?term=286053 "C8orf36, MMS21, NSE2, ZMIZ7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039179 286053 NSMCE2 http://www.ncbi.nlm.nih.gov/gene/?term=286053 "C8orf36, MMS21, NSE2, ZMIZ7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039180 2869 GRK5 http://www.ncbi.nlm.nih.gov/gene/?term=2869 GPRK5 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039181 2869 GRK5 http://www.ncbi.nlm.nih.gov/gene/?term=2869 GPRK5 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039182 287 ANK2 http://www.ncbi.nlm.nih.gov/gene/?term=287 "ANK-2, LQT4, brank-2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039183 288 ANK3 http://www.ncbi.nlm.nih.gov/gene/?term=288 "ANKYRIN-G, MRT37" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039184 288 ANK3 http://www.ncbi.nlm.nih.gov/gene/?term=288 "ANKYRIN-G, MRT37" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039185 2887 GRB10 http://www.ncbi.nlm.nih.gov/gene/?term=2887 "GRB-IR, Grb-10, IRBP, MEG1, RSS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039186 2887 GRB10 http://www.ncbi.nlm.nih.gov/gene/?term=2887 "GRB-IR, Grb-10, IRBP, MEG1, RSS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039187 2889 RAPGEF1 http://www.ncbi.nlm.nih.gov/gene/?term=2889 "C3G, GRF2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039188 2889 RAPGEF1 http://www.ncbi.nlm.nih.gov/gene/?term=2889 "C3G, GRF2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039189 2892 GRIA3 http://www.ncbi.nlm.nih.gov/gene/?term=2892 "GLUR-C, GLUR-K3, GLUR3, GLURC, GluA3, MRX94" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039190 2892 GRIA3 http://www.ncbi.nlm.nih.gov/gene/?term=2892 "GLUR-C, GLUR-K3, GLUR3, GLURC, GluA3, MRX94" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039191 28955 DEXI http://www.ncbi.nlm.nih.gov/gene/?term=28955 MYLE mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039192 28955 DEXI http://www.ncbi.nlm.nih.gov/gene/?term=28955 MYLE mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039193 28957 MRPS28 http://www.ncbi.nlm.nih.gov/gene/?term=28957 "HSPC007, MRP-S28, MRP-S35, MRPS35" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039194 28969 BZW2 http://www.ncbi.nlm.nih.gov/gene/?term=28969 "HSPC028, MST017, MSTP017" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039195 28969 BZW2 http://www.ncbi.nlm.nih.gov/gene/?term=28969 "HSPC028, MST017, MSTP017" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039196 28971 AAMDC http://www.ncbi.nlm.nih.gov/gene/?term=28971 "C11orf67, CK067, PTD015" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039197 28971 AAMDC http://www.ncbi.nlm.nih.gov/gene/?term=28971 "C11orf67, CK067, PTD015" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039198 28977 MRPL42 http://www.ncbi.nlm.nih.gov/gene/?term=28977 "HSPC204, L31MT, L42MT, MRP-L31, MRP-L42, MRP-S32, MRPL31, MRPS32, PTD007, RPML31, S32MT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039199 28984 RGCC http://www.ncbi.nlm.nih.gov/gene/?term=28984 "C13orf15, RGC-32, RGC32, bA157L14.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039200 28984 RGCC http://www.ncbi.nlm.nih.gov/gene/?term=28984 "C13orf15, RGC-32, RGC32, bA157L14.2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039201 28988 DBNL http://www.ncbi.nlm.nih.gov/gene/?term=28988 "ABP1, HIP-55, HIP55, SH3P7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039202 28988 DBNL http://www.ncbi.nlm.nih.gov/gene/?term=28988 "ABP1, HIP-55, HIP55, SH3P7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039203 28992 MACROD1 http://www.ncbi.nlm.nih.gov/gene/?term=28992 LRP16 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039204 28992 MACROD1 http://www.ncbi.nlm.nih.gov/gene/?term=28992 LRP16 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039205 28996 HIPK2 http://www.ncbi.nlm.nih.gov/gene/?term=28996 PRO0593 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039206 28996 HIPK2 http://www.ncbi.nlm.nih.gov/gene/?term=28996 PRO0593 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039207 29 ABR http://www.ncbi.nlm.nih.gov/gene/?term=29 MDB mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039208 29 ABR http://www.ncbi.nlm.nih.gov/gene/?term=29 MDB mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039209 29028 ATAD2 http://www.ncbi.nlm.nih.gov/gene/?term=29028 "ANCCA, CT137, PRO2000" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039210 29028 ATAD2 http://www.ncbi.nlm.nih.gov/gene/?term=29028 "ANCCA, CT137, PRO2000" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039211 29035 C16orf72 http://www.ncbi.nlm.nih.gov/gene/?term=29035 PRO0149 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039212 29035 C16orf72 http://www.ncbi.nlm.nih.gov/gene/?term=29035 PRO0149 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039213 29062 WDR91 http://www.ncbi.nlm.nih.gov/gene/?term=29062 "HSPC049, SORF-1, SORF1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039214 29062 WDR91 http://www.ncbi.nlm.nih.gov/gene/?term=29062 "HSPC049, SORF-1, SORF1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039215 29072 SETD2 http://www.ncbi.nlm.nih.gov/gene/?term=29072 "HBP231, HIF-1, HIP-1, HSPC069, HYPB, KMT3A, LLS, SET2, p231HBP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039216 29072 SETD2 http://www.ncbi.nlm.nih.gov/gene/?term=29072 "HBP231, HIF-1, HIP-1, HSPC069, HYPB, KMT3A, LLS, SET2, p231HBP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039217 2908 NR3C1 http://www.ncbi.nlm.nih.gov/gene/?term=2908 "GCCR, GCR, GCRST, GR, GRL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039218 2908 NR3C1 http://www.ncbi.nlm.nih.gov/gene/?term=2908 "GCCR, GCR, GCRST, GR, GRL" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039219 29102 DROSHA http://www.ncbi.nlm.nih.gov/gene/?term=29102 "ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039220 29115 SAP30BP http://www.ncbi.nlm.nih.gov/gene/?term=29115 "HCNGP, HTRG, HTRP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039221 29115 SAP30BP http://www.ncbi.nlm.nih.gov/gene/?term=29115 "HCNGP, HTRG, HTRP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039222 29116 MYLIP http://www.ncbi.nlm.nih.gov/gene/?term=29116 "IDOL, MIR" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039223 29116 MYLIP http://www.ncbi.nlm.nih.gov/gene/?term=29116 "IDOL, MIR" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039224 29123 ANKRD11 http://www.ncbi.nlm.nih.gov/gene/?term=29123 "ANCO-1, ANCO1, LZ16, T13" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039225 29123 ANKRD11 http://www.ncbi.nlm.nih.gov/gene/?term=29123 "ANCO-1, ANCO1, LZ16, T13" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039226 2932 GSK3B http://www.ncbi.nlm.nih.gov/gene/?term=2932 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039227 2932 GSK3B http://www.ncbi.nlm.nih.gov/gene/?term=2932 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039228 2934 GSN http://www.ncbi.nlm.nih.gov/gene/?term=2934 "ADF, AGEL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039229 2934 GSN http://www.ncbi.nlm.nih.gov/gene/?term=2934 "ADF, AGEL" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039230 2965 GTF2H1 http://www.ncbi.nlm.nih.gov/gene/?term=2965 "BTF2, P62, TFB1, TFIIH" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039231 2965 GTF2H1 http://www.ncbi.nlm.nih.gov/gene/?term=2965 "BTF2, P62, TFB1, TFIIH" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039232 2969 GTF2I http://www.ncbi.nlm.nih.gov/gene/?term=2969 "WBS, DIWS, SPIN, IB291, BAP135, BTKAP1, TFII-I, WBSCR6, GTFII-I" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039233 2971 GTF3A http://www.ncbi.nlm.nih.gov/gene/?term=2971 "AP2, TFIIIA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039234 2975 GTF3C1 http://www.ncbi.nlm.nih.gov/gene/?term=2975 "TFIIIC, TFIIIC220, TFIIICalpha" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039235 2975 GTF3C1 http://www.ncbi.nlm.nih.gov/gene/?term=2975 "TFIIIC, TFIIIC220, TFIIICalpha" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039236 29766 TMOD3 http://www.ncbi.nlm.nih.gov/gene/?term=29766 UTMOD mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039237 29766 TMOD3 http://www.ncbi.nlm.nih.gov/gene/?term=29766 UTMOD mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039238 2977 GUCY1A2 http://www.ncbi.nlm.nih.gov/gene/?term=2977 "GC-SA2, GUC1A2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039239 2978 GUCA1A http://www.ncbi.nlm.nih.gov/gene/?term=2978 "C6orf131, COD3, CORD14, GCAP, GCAP1, GUCA, GUCA1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039240 2978 GUCA1A http://www.ncbi.nlm.nih.gov/gene/?term=2978 "C6orf131, COD3, CORD14, GCAP, GCAP1, GUCA, GUCA1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039241 29780 PARVB http://www.ncbi.nlm.nih.gov/gene/?term=29780 CGI-56 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039242 29780 PARVB http://www.ncbi.nlm.nih.gov/gene/?term=29780 CGI-56 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039243 29789 OLA1 http://www.ncbi.nlm.nih.gov/gene/?term=29789 "DOC45, GBP45, GTBP9, GTPBP9, PTD004" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039244 29789 OLA1 http://www.ncbi.nlm.nih.gov/gene/?term=29789 "DOC45, GBP45, GTBP9, GTPBP9, PTD004" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039245 29801 ZDHHC8 http://www.ncbi.nlm.nih.gov/gene/?term=29801 "DHHC8, ZDHHCL1, ZNF378" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039246 29855 UBN1 http://www.ncbi.nlm.nih.gov/gene/?term=29855 "VT, VT4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039247 29855 UBN1 http://www.ncbi.nlm.nih.gov/gene/?term=29855 "VT, VT4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039248 29880 ALG5 http://www.ncbi.nlm.nih.gov/gene/?term=29880 bA421P11.2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039249 29880 ALG5 http://www.ncbi.nlm.nih.gov/gene/?term=29880 bA421P11.2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039250 29894 CPSF1 http://www.ncbi.nlm.nih.gov/gene/?term=29894 "CPSF160, HSU37012, P/cl.18" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039251 29894 CPSF1 http://www.ncbi.nlm.nih.gov/gene/?term=29894 "CPSF160, HSU37012, P/cl.18" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039252 29896 TRA2A http://www.ncbi.nlm.nih.gov/gene/?term=29896 "AWMS1, HSU53209" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039253 29904 EEF2K http://www.ncbi.nlm.nih.gov/gene/?term=29904 "HSU93850, eEF-2K" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039254 29906 ST8SIA5 http://www.ncbi.nlm.nih.gov/gene/?term=29906 "SIAT8-E, SIAT8E, ST8SiaV" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039255 29956 CERS2 http://www.ncbi.nlm.nih.gov/gene/?term=29956 "L3, LASS2, SP260, TMSG1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039256 29956 CERS2 http://www.ncbi.nlm.nih.gov/gene/?term=29956 "L3, LASS2, SP260, TMSG1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039257 29960 MRM2 http://www.ncbi.nlm.nih.gov/gene/?term=29960 "FJH1, FTSJ2, HEL97, RRMJ2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039258 29960 MRM2 http://www.ncbi.nlm.nih.gov/gene/?term=29960 "FJH1, FTSJ2, HEL97, RRMJ2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039259 29966 STRN3 http://www.ncbi.nlm.nih.gov/gene/?term=29966 "PPP2R6B, S/G2NA, SG2NA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039260 29980 DONSON http://www.ncbi.nlm.nih.gov/gene/?term=29980 "B17, C21orf60, MIMIS, MISSLA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039261 29980 DONSON http://www.ncbi.nlm.nih.gov/gene/?term=29980 "B17, C21orf60, MIMIS, MISSLA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039262 29990 PILRB http://www.ncbi.nlm.nih.gov/gene/?term=29990 "FDFACT1, FDFACT2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039263 29990 PILRB http://www.ncbi.nlm.nih.gov/gene/?term=29990 "FDFACT1, FDFACT2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039264 29992 PILRA http://www.ncbi.nlm.nih.gov/gene/?term=29992 FDF03 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039265 29992 PILRA http://www.ncbi.nlm.nih.gov/gene/?term=29992 FDF03 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039266 30 ACAA1 http://www.ncbi.nlm.nih.gov/gene/?term=30 "ACAA, PTHIO, THIO" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039267 30001 ERO1A http://www.ncbi.nlm.nih.gov/gene/?term=30001 "ERO1-L, ERO1-L-alpha, ERO1-alpha, ERO1L, ERO1LA, Ero1alpha" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039268 30001 ERO1A http://www.ncbi.nlm.nih.gov/gene/?term=30001 "ERO1-L, ERO1-L-alpha, ERO1-alpha, ERO1L, ERO1LA, Ero1alpha" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039269 3017 HIST1H2BD http://www.ncbi.nlm.nih.gov/gene/?term=3017 "H2B.1B, H2B/b, H2BFB, HIRIP2, dJ221C16.6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039270 302 ANXA2 http://www.ncbi.nlm.nih.gov/gene/?term=302 "ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039271 302 ANXA2 http://www.ncbi.nlm.nih.gov/gene/?term=302 "ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039272 3054 HCFC1 http://www.ncbi.nlm.nih.gov/gene/?term=3054 "CFF, HCF, HCF-1, HCF1, HFC1, MRX3, PPP1R89, VCAF" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039273 3055 HCK http://www.ncbi.nlm.nih.gov/gene/?term=3055 "JTK9, p59Hck, p61Hck" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039274 3055 HCK http://www.ncbi.nlm.nih.gov/gene/?term=3055 "JTK9, p59Hck, p61Hck" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039275 3064 HTT http://www.ncbi.nlm.nih.gov/gene/?term=3064 "HD, IT15, LOMARS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039276 3064 HTT http://www.ncbi.nlm.nih.gov/gene/?term=3064 "HD, IT15, LOMARS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039277 3069 HDLBP http://www.ncbi.nlm.nih.gov/gene/?term=3069 "HBP, PRO2900, VGL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039278 3069 HDLBP http://www.ncbi.nlm.nih.gov/gene/?term=3069 "HBP, PRO2900, VGL" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039279 3074 HEXB http://www.ncbi.nlm.nih.gov/gene/?term=3074 "ENC-1AS, HEL-248, HEL-S-111" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039280 30811 HUNK http://www.ncbi.nlm.nih.gov/gene/?term=30811 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039281 30811 HUNK http://www.ncbi.nlm.nih.gov/gene/?term=30811 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039282 30833 NT5C http://www.ncbi.nlm.nih.gov/gene/?term=30833 "DNT, DNT1, HEL74, P5N2, PN-I, PN-II, UMPH2, cdN, dNT-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039283 30833 NT5C http://www.ncbi.nlm.nih.gov/gene/?term=30833 "DNT, DNT1, HEL74, P5N2, PN-I, PN-II, UMPH2, cdN, dNT-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039284 30844 EHD4 http://www.ncbi.nlm.nih.gov/gene/?term=30844 PAST4 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039285 30844 EHD4 http://www.ncbi.nlm.nih.gov/gene/?term=30844 PAST4 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039286 3092 HIP1 http://www.ncbi.nlm.nih.gov/gene/?term=3092 "HIP-I, ILWEQ, SHON, SHONbeta, SHONgamma" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039287 3092 HIP1 http://www.ncbi.nlm.nih.gov/gene/?term=3092 "HIP-I, ILWEQ, SHON, SHONbeta, SHONgamma" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039288 3093 UBE2K http://www.ncbi.nlm.nih.gov/gene/?term=3093 "E2-25K, HIP2, HYPG, LIG, UBC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039289 3093 UBE2K http://www.ncbi.nlm.nih.gov/gene/?term=3093 "E2-25K, HIP2, HYPG, LIG, UBC1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039290 3096 HIVEP1 http://www.ncbi.nlm.nih.gov/gene/?term=3096 "CIRIP, CRYBP1, GAAP, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40, ZNF40A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039291 3096 HIVEP1 http://www.ncbi.nlm.nih.gov/gene/?term=3096 "CIRIP, CRYBP1, GAAP, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40, ZNF40A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039292 31 ACACA http://www.ncbi.nlm.nih.gov/gene/?term=31 "ACC, ACAC, ACC1, ACCA, ACACAD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039293 310 ANXA7 http://www.ncbi.nlm.nih.gov/gene/?term=310 "ANX7, SNX, SYNEXIN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039294 3104 ZBTB48 http://www.ncbi.nlm.nih.gov/gene/?term=3104 "HKR3, TZAP, ZNF855, pp9964" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039295 3104 ZBTB48 http://www.ncbi.nlm.nih.gov/gene/?term=3104 "HKR3, TZAP, ZNF855, pp9964" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039296 317648 NOP14-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=317648 "C4orf10, RES4-24" lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00039297 317648 NOP14-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=317648 "C4orf10, RES4-24" lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00039298 3183 HNRNPC http://www.ncbi.nlm.nih.gov/gene/?term=3183 "C1, C2, HNRNP, HNRPC, SNRPC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039299 3184 HNRNPD http://www.ncbi.nlm.nih.gov/gene/?term=3184 "AUF1, AUF1A, HNRPD, P37, hnRNPD0" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039300 3185 HNRNPF http://www.ncbi.nlm.nih.gov/gene/?term=3185 "HNRPF, OK/SW-cl.23, mcs94-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039301 3185 HNRNPF http://www.ncbi.nlm.nih.gov/gene/?term=3185 "HNRPF, OK/SW-cl.23, mcs94-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039302 3213 HOXB3 http://www.ncbi.nlm.nih.gov/gene/?term=3213 "HOX2, HOX2G, Hox-2.7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039303 3213 HOXB3 http://www.ncbi.nlm.nih.gov/gene/?term=3213 "HOX2, HOX2G, Hox-2.7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039304 3216 HOXB6 http://www.ncbi.nlm.nih.gov/gene/?term=3216 "HOX2, HOX2B, HU-2, Hox-2.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039305 3216 HOXB6 http://www.ncbi.nlm.nih.gov/gene/?term=3216 "HOX2, HOX2B, HU-2, Hox-2.2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039306 323 APBB2 http://www.ncbi.nlm.nih.gov/gene/?term=323 "FE65L, FE65L1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039307 323 APBB2 http://www.ncbi.nlm.nih.gov/gene/?term=323 "FE65L, FE65L1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039308 3241 HPCAL1 http://www.ncbi.nlm.nih.gov/gene/?term=3241 "BDR1, HLP2, VILIP-3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039309 3241 HPCAL1 http://www.ncbi.nlm.nih.gov/gene/?term=3241 "BDR1, HLP2, VILIP-3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039310 3291 HSD11B2 http://www.ncbi.nlm.nih.gov/gene/?term=3291 "AME, AME1, HSD11K, HSD2, SDR9C3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039311 3291 HSD11B2 http://www.ncbi.nlm.nih.gov/gene/?term=3291 "AME, AME1, HSD11K, HSD2, SDR9C3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039312 3339 HSPG2 http://www.ncbi.nlm.nih.gov/gene/?term=3339 "HSPG, PLC, PRCAN, SJA, SJS, SJS1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039313 3339 HSPG2 http://www.ncbi.nlm.nih.gov/gene/?term=3339 "HSPG, PLC, PRCAN, SJA, SJS, SJS1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039314 334 APLP2 http://www.ncbi.nlm.nih.gov/gene/?term=334 "APLP-2, APPH, APPL2, CDEBP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039315 3340 NDST1 http://www.ncbi.nlm.nih.gov/gene/?term=3340 "HSST, MRT46, NST1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039316 3371 TNC http://www.ncbi.nlm.nih.gov/gene/?term=3371 "150-225, DFNA56, GMEM, GP, HXB, JI, TN, TN-C" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039317 337867 UBAC2 http://www.ncbi.nlm.nih.gov/gene/?term=337867 PHGDHL1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039318 337867 UBAC2 http://www.ncbi.nlm.nih.gov/gene/?term=337867 PHGDHL1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039319 339487 ZBTB8OS http://www.ncbi.nlm.nih.gov/gene/?term=339487 "ARCH, ARCH2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039320 3418 IDH2 http://www.ncbi.nlm.nih.gov/gene/?term=3418 "D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039321 344148 NCKAP5 http://www.ncbi.nlm.nih.gov/gene/?term=344148 "ERIH1, ERIH2, NAP5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039322 3455 IFNAR2 http://www.ncbi.nlm.nih.gov/gene/?term=3455 "IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039323 346389 MACC1 http://www.ncbi.nlm.nih.gov/gene/?term=346389 "7A5, SH3BP4L" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039324 3480 IGF1R http://www.ncbi.nlm.nih.gov/gene/?term=3480 "CD221, IGFIR, IGFR, JTK13" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039325 3480 IGF1R http://www.ncbi.nlm.nih.gov/gene/?term=3480 "CD221, IGFIR, IGFR, JTK13" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039326 3482 IGF2R http://www.ncbi.nlm.nih.gov/gene/?term=3482 "CD222, CI-M6PR, CIMPR, M6P-R, M6P/IGF2R, MPR 300, MPR1, MPR300, MPRI" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039327 3482 IGF2R http://www.ncbi.nlm.nih.gov/gene/?term=3482 "CD222, CI-M6PR, CIMPR, M6P-R, M6P/IGF2R, MPR 300, MPR1, MPR300, MPRI" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039328 3487 IGFBP4 http://www.ncbi.nlm.nih.gov/gene/?term=3487 "BP-4, HT29-IGFBP, IBP4, IGFBP-4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039329 3487 IGFBP4 http://www.ncbi.nlm.nih.gov/gene/?term=3487 "BP-4, HT29-IGFBP, IBP4, IGFBP-4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039330 348793 WDR53 http://www.ncbi.nlm.nih.gov/gene/?term=348793 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039331 3490 IGFBP7 http://www.ncbi.nlm.nih.gov/gene/?term=3490 "AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039332 3490 IGFBP7 http://www.ncbi.nlm.nih.gov/gene/?term=3490 "AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039333 351 APP http://www.ncbi.nlm.nih.gov/gene/?term=351 "AAA, ABETA, ABPP, AD1I, CTFgamma, CVAP, PN-II, PN2, preA4, APP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039334 3516 RBPJ http://www.ncbi.nlm.nih.gov/gene/?term=3516 "AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-JK, RBPSUH, SUH, csl, RBPJ" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039335 3603 IL16 http://www.ncbi.nlm.nih.gov/gene/?term=3603 "LCF, NIL16, PRIL16, prIL-16" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039336 3603 IL16 http://www.ncbi.nlm.nih.gov/gene/?term=3603 "LCF, NIL16, PRIL16, prIL-16" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039337 3606 IL18 http://www.ncbi.nlm.nih.gov/gene/?term=3606 "IGIF, IL-18, IL-1g, IL1F4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039338 3606 IL18 http://www.ncbi.nlm.nih.gov/gene/?term=3606 "IGIF, IL-18, IL-1g, IL1F4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039339 3607 FOXK2 http://www.ncbi.nlm.nih.gov/gene/?term=3607 "ILF, ILF-1, ILF1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039340 3607 FOXK2 http://www.ncbi.nlm.nih.gov/gene/?term=3607 "ILF, ILF-1, ILF1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039341 3613 IMPA2 http://www.ncbi.nlm.nih.gov/gene/?term=3613 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039342 3613 IMPA2 http://www.ncbi.nlm.nih.gov/gene/?term=3613 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039343 3632 INPP5A http://www.ncbi.nlm.nih.gov/gene/?term=3632 5PTASE mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039344 3632 INPP5A http://www.ncbi.nlm.nih.gov/gene/?term=3632 5PTASE mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039345 3643 INSR http://www.ncbi.nlm.nih.gov/gene/?term=3643 "CD220, HHF5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039346 3643 INSR http://www.ncbi.nlm.nih.gov/gene/?term=3643 "CD220, HHF5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039347 3646 EIF3E http://www.ncbi.nlm.nih.gov/gene/?term=3646 "EIF3-P48, EIF3S6, INT6, eIF3-p46" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039348 3655 ITGA6 http://www.ncbi.nlm.nih.gov/gene/?term=3655 "CD49fB, VLA-6, ITGA6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039349 3655 ITGA6 http://www.ncbi.nlm.nih.gov/gene/?term=3655 "CD49fB, VLA-6, ITGA6" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039350 3658 IREB2 http://www.ncbi.nlm.nih.gov/gene/?term=3658 "ACO3, IRP2, IRP2AD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039351 3660 IRF2 http://www.ncbi.nlm.nih.gov/gene/?term=3660 IRF-2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039352 3660 IRF2 http://www.ncbi.nlm.nih.gov/gene/?term=3660 IRF-2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039353 3667 IRS1 http://www.ncbi.nlm.nih.gov/gene/?term=3667 HIRS-1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039354 3667 IRS1 http://www.ncbi.nlm.nih.gov/gene/?term=3667 HIRS-1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039355 3675 ITGA3 http://www.ncbi.nlm.nih.gov/gene/?term=3675 "CD49C, FRP-2, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039356 3675 ITGA3 http://www.ncbi.nlm.nih.gov/gene/?term=3675 "CD49C, FRP-2, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039357 3680 ITGA9 http://www.ncbi.nlm.nih.gov/gene/?term=3680 "ALPHA-RLC, ITGA4L, RLC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039358 3680 ITGA9 http://www.ncbi.nlm.nih.gov/gene/?term=3680 "ALPHA-RLC, ITGA4L, RLC" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039359 3696 ITGB8 http://www.ncbi.nlm.nih.gov/gene/?term=3696 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039360 3704 ITPA http://www.ncbi.nlm.nih.gov/gene/?term=3704 "C20orf37, HLC14-06-P, ITPase, My049, NTPase, dJ794I6.3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039361 3704 ITPA http://www.ncbi.nlm.nih.gov/gene/?term=3704 "C20orf37, HLC14-06-P, ITPase, My049, NTPase, dJ794I6.3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039362 3705 ITPK1 http://www.ncbi.nlm.nih.gov/gene/?term=3705 ITRPK1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039363 3705 ITPK1 http://www.ncbi.nlm.nih.gov/gene/?term=3705 ITRPK1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039364 3708 ITPR1 http://www.ncbi.nlm.nih.gov/gene/?term=3708 "ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039365 3709 ITPR2 http://www.ncbi.nlm.nih.gov/gene/?term=3709 "ANHD, CFAP48, INSP3R2, IP3R2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039366 3709 ITPR2 http://www.ncbi.nlm.nih.gov/gene/?term=3709 "ANHD, CFAP48, INSP3R2, IP3R2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039367 3712 IVD http://www.ncbi.nlm.nih.gov/gene/?term=3712 ACAD2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039368 3712 IVD http://www.ncbi.nlm.nih.gov/gene/?term=3712 ACAD2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039369 3716 JAK1 http://www.ncbi.nlm.nih.gov/gene/?term=3716 "JAK1AB, JTK3, JAK1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039370 3716 JAK1 http://www.ncbi.nlm.nih.gov/gene/?term=3716 "JAK1AB, JTK3, JAK1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039371 3720 JARID2 http://www.ncbi.nlm.nih.gov/gene/?term=3720 JMJ mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039372 3735 KARS http://www.ncbi.nlm.nih.gov/gene/?term=3735 "CMTRIB, DFNB891, KARS2, KRS, KARS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039373 3735 KARS http://www.ncbi.nlm.nih.gov/gene/?term=3735 "CMTRIB, DFNB891, KARS2, KRS, KARS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039374 3737 KCNA2 http://www.ncbi.nlm.nih.gov/gene/?term=3737 "EIEE32, HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039375 3737 KCNA2 http://www.ncbi.nlm.nih.gov/gene/?term=3737 "EIEE32, HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039376 374378 GALNT18 http://www.ncbi.nlm.nih.gov/gene/?term=374378 "GALNACT18, GALNT15, GALNTL4, GalNAc-T15, GalNAc-T18" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039377 374378 GALNT18 http://www.ncbi.nlm.nih.gov/gene/?term=374378 "GALNACT18, GALNT15, GALNTL4, GalNAc-T15, GalNAc-T18" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039378 374618 TEX9 http://www.ncbi.nlm.nih.gov/gene/?term=374618 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039379 374618 TEX9 http://www.ncbi.nlm.nih.gov/gene/?term=374618 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039380 374654 KIF7 http://www.ncbi.nlm.nih.gov/gene/?term=374654 "ACLS, AGBK, HLS2, JBTS12, UNQ340" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039381 374868 ATP9B http://www.ncbi.nlm.nih.gov/gene/?term=374868 "ATPASEP, ATPIIB, HUSSY-20, NEO1L, hMMR1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039382 374868 ATP9B http://www.ncbi.nlm.nih.gov/gene/?term=374868 "ATPASEP, ATPIIB, HUSSY-20, NEO1L, hMMR1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039383 3749 KCNC4 http://www.ncbi.nlm.nih.gov/gene/?term=3749 "C1orf30, HKSHIIIC, KSHIIIC, KV3.4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039384 3749 KCNC4 http://www.ncbi.nlm.nih.gov/gene/?term=3749 "C1orf30, HKSHIIIC, KSHIIIC, KV3.4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039385 375 ARF1 http://www.ncbi.nlm.nih.gov/gene/?term=375 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039386 375190 FAM228B http://www.ncbi.nlm.nih.gov/gene/?term=375190 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039387 375190 FAM228B http://www.ncbi.nlm.nih.gov/gene/?term=375190 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039388 378 ARF4 http://www.ncbi.nlm.nih.gov/gene/?term=378 ARF2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039389 3784 KCNQ1 http://www.ncbi.nlm.nih.gov/gene/?term=3784 "ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, KVLQT1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, WRS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039390 3784 KCNQ1 http://www.ncbi.nlm.nih.gov/gene/?term=3784 "ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, KVLQT1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, WRS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039391 3786 KCNQ3 http://www.ncbi.nlm.nih.gov/gene/?term=3786 "BFNC2, EBN2, KV7.3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039392 3786 KCNQ3 http://www.ncbi.nlm.nih.gov/gene/?term=3786 "BFNC2, EBN2, KV7.3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039393 3796 KIF2A http://www.ncbi.nlm.nih.gov/gene/?term=3796 "CDCBM3, HK2, KIF2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039394 3796 KIF2A http://www.ncbi.nlm.nih.gov/gene/?term=3796 "CDCBM3, HK2, KIF2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039395 3831 KLC1 http://www.ncbi.nlm.nih.gov/gene/?term=3831 "KLC, KNS2, KNS2A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039396 3831 KLC1 http://www.ncbi.nlm.nih.gov/gene/?term=3831 "KLC, KNS2, KNS2A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039397 3837 KPNB1 http://www.ncbi.nlm.nih.gov/gene/?term=3837 "IMB1, IPO1, IPOB, Impnb, NTF97" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039398 3837 KPNB1 http://www.ncbi.nlm.nih.gov/gene/?term=3837 "IMB1, IPO1, IPOB, Impnb, NTF97" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039399 3839 KPNA3 http://www.ncbi.nlm.nih.gov/gene/?term=3839 "IPOA4, SRP1, SRP1gamma, SRP4, hSRP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039400 3840 KPNA4 http://www.ncbi.nlm.nih.gov/gene/?term=3840 "IPOA3, QIP1, SRP3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039401 3840 KPNA4 http://www.ncbi.nlm.nih.gov/gene/?term=3840 "IPOA3, QIP1, SRP3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039402 3842 TNPO1 http://www.ncbi.nlm.nih.gov/gene/?term=3842 "IPO2, KPNB2, MIP, MIP1, TRN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039403 3842 TNPO1 http://www.ncbi.nlm.nih.gov/gene/?term=3842 "IPO2, KPNB2, MIP, MIP1, TRN" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039404 3845 KRAS http://www.ncbi.nlm.nih.gov/gene/?term=3845 "C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, KI-RAS1, KRAS2, NS, NS3, RALD, RASK2, c-Ki-ras2, KRAS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039405 387 RHOA http://www.ncbi.nlm.nih.gov/gene/?term=387 "ARH12, ARHA, RHO12, RHOH12" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039406 387129 NPSR1 http://www.ncbi.nlm.nih.gov/gene/?term=387129 "ASRT2, GPR154, GPRA, NPSR, PGR14, VRR1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039407 387129 NPSR1 http://www.ncbi.nlm.nih.gov/gene/?term=387129 "ASRT2, GPR154, GPRA, NPSR, PGR14, VRR1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039408 3899 AFF3 http://www.ncbi.nlm.nih.gov/gene/?term=3899 "LAF4, MLLT2-like" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039409 3899 AFF3 http://www.ncbi.nlm.nih.gov/gene/?term=3899 "LAF4, MLLT2-like" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039410 390 RND3 http://www.ncbi.nlm.nih.gov/gene/?term=390 "ARHE, Rho8, RhoE, memB" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039411 3910 LAMA4 http://www.ncbi.nlm.nih.gov/gene/?term=3910 "CMD1JJ, LAMA3*-1, LAMA4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039412 3910 LAMA4 http://www.ncbi.nlm.nih.gov/gene/?term=3910 "CMD1JJ, LAMA3*-1, LAMA4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039413 3912 LAMB1 http://www.ncbi.nlm.nih.gov/gene/?term=3912 "CLM, LIS5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039414 3912 LAMB1 http://www.ncbi.nlm.nih.gov/gene/?term=3912 "CLM, LIS5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039415 3933 LCN1 http://www.ncbi.nlm.nih.gov/gene/?term=3933 "PMFA, TLC, TP, VEGP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039416 3933 LCN1 http://www.ncbi.nlm.nih.gov/gene/?term=3933 "PMFA, TLC, TP, VEGP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039417 3936 LCP1 http://www.ncbi.nlm.nih.gov/gene/?term=3936 "CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039418 3936 LCP1 http://www.ncbi.nlm.nih.gov/gene/?term=3936 "CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039419 3983 ABLIM1 http://www.ncbi.nlm.nih.gov/gene/?term=3983 "ABLIM, LIMAB1, LIMATIN, abLIM-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039420 3985 LIMK2 http://www.ncbi.nlm.nih.gov/gene/?term=3985 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039421 399665 FAM102A http://www.ncbi.nlm.nih.gov/gene/?term=399665 "C9orf132, EEIG1, SYM-3A, bA203J24.7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039422 399665 FAM102A http://www.ncbi.nlm.nih.gov/gene/?term=399665 "C9orf132, EEIG1, SYM-3A, bA203J24.7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039423 3998 LMAN1 http://www.ncbi.nlm.nih.gov/gene/?term=3998 "ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039424 4008 LMO7 http://www.ncbi.nlm.nih.gov/gene/?term=4008 "FBX20, FBXO20b, LOMP, LMO7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039425 4012 LNPEP http://www.ncbi.nlm.nih.gov/gene/?term=4012 "CAP, IRAP, P-LAP, PLAP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039426 4012 LNPEP http://www.ncbi.nlm.nih.gov/gene/?term=4012 "CAP, IRAP, P-LAP, PLAP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039427 4026 LPP http://www.ncbi.nlm.nih.gov/gene/?term=4026 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039428 404266 HOXB-AS3 http://www.ncbi.nlm.nih.gov/gene/?term=404266 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00039429 404266 HOXB-AS3 http://www.ncbi.nlm.nih.gov/gene/?term=404266 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00039430 4045 LSAMP http://www.ncbi.nlm.nih.gov/gene/?term=4045 "IGLON3, LAMP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039431 4045 LSAMP http://www.ncbi.nlm.nih.gov/gene/?term=4045 "IGLON3, LAMP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039432 404550 C16orf74 http://www.ncbi.nlm.nih.gov/gene/?term=404550 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039433 404550 C16orf74 http://www.ncbi.nlm.nih.gov/gene/?term=404550 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039434 4074 M6PR http://www.ncbi.nlm.nih.gov/gene/?term=4074 "CD-M6PR, CD-MPR, MPR 46, MPR-46, MPR46, SMPR" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039435 4074 M6PR http://www.ncbi.nlm.nih.gov/gene/?term=4074 "CD-M6PR, CD-MPR, MPR 46, MPR-46, MPR46, SMPR" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039436 408 ARRB1 http://www.ncbi.nlm.nih.gov/gene/?term=408 "ARB1, ARR1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039437 408 ARRB1 http://www.ncbi.nlm.nih.gov/gene/?term=408 "ARB1, ARR1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039438 4084 MXD1 http://www.ncbi.nlm.nih.gov/gene/?term=4084 "BHLHC58, MAD, MAD1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039439 4088 SMAD3 http://www.ncbi.nlm.nih.gov/gene/?term=4088 "HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039440 4088 SMAD3 http://www.ncbi.nlm.nih.gov/gene/?term=4088 "HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039441 4091 SMAD6 http://www.ncbi.nlm.nih.gov/gene/?term=4091 "AOVD2, HsT17432, MADH6, MADH7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039442 4091 SMAD6 http://www.ncbi.nlm.nih.gov/gene/?term=4091 "AOVD2, HsT17432, MADH6, MADH7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039443 4093 SMAD9 http://www.ncbi.nlm.nih.gov/gene/?term=4093 "MADH6, MADH9, PPH2, SMAD8, SMAD8/9, SMAD8A, SMAD8B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039444 4093 SMAD9 http://www.ncbi.nlm.nih.gov/gene/?term=4093 "MADH6, MADH9, PPH2, SMAD8, SMAD8/9, SMAD8A, SMAD8B" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039445 4121 MAN1A1 http://www.ncbi.nlm.nih.gov/gene/?term=4121 "HUMM3, HUMM9, MAN9" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039446 4121 MAN1A1 http://www.ncbi.nlm.nih.gov/gene/?term=4121 "HUMM3, HUMM9, MAN9" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039447 4124 MAN2A1 http://www.ncbi.nlm.nih.gov/gene/?term=4124 "AMan II, GOLIM7, MANA2, MANII" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039448 4133 MAP2 http://www.ncbi.nlm.nih.gov/gene/?term=4133 "MAP2AB, MAP2C, MAP2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039449 4140 MARK3 http://www.ncbi.nlm.nih.gov/gene/?term=4140 "CTAK1, KP78, PAR1A, Par-1a" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039450 4140 MARK3 http://www.ncbi.nlm.nih.gov/gene/?term=4140 "CTAK1, KP78, PAR1A, Par-1a" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039451 414777 HCG18 http://www.ncbi.nlm.nih.gov/gene/?term=414777 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00039452 414777 HCG18 http://www.ncbi.nlm.nih.gov/gene/?term=414777 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00039453 4149 MAX http://www.ncbi.nlm.nih.gov/gene/?term=4149 bHLHd4 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039454 4154 MBNL1 http://www.ncbi.nlm.nih.gov/gene/?term=4154 "EXP, MBNL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039455 4163 MCC http://www.ncbi.nlm.nih.gov/gene/?term=4163 MCC1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039456 4163 MCC http://www.ncbi.nlm.nih.gov/gene/?term=4163 MCC1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039457 4193 MDM2 http://www.ncbi.nlm.nih.gov/gene/?term=4193 "ACTFS, HDMX, hdm2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039458 4194 MDM4 http://www.ncbi.nlm.nih.gov/gene/?term=4194 "HDMX, MDMX, MRP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039459 4204 MECP2 http://www.ncbi.nlm.nih.gov/gene/?term=4204 "AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039460 4204 MECP2 http://www.ncbi.nlm.nih.gov/gene/?term=4204 "AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039461 4205 MEF2A http://www.ncbi.nlm.nih.gov/gene/?term=4205 "ADCAD1, RSRFC4, RSRFC9, mef2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039462 4208 MEF2C http://www.ncbi.nlm.nih.gov/gene/?term=4208 "C5DELq14.3, DEL5q14.3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039463 4209 MEF2D http://www.ncbi.nlm.nih.gov/gene/?term=4209 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039464 4209 MEF2D http://www.ncbi.nlm.nih.gov/gene/?term=4209 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039465 4215 MAP3K3 http://www.ncbi.nlm.nih.gov/gene/?term=4215 "MAPKKK3, MEKK3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039466 4217 MAP3K5 http://www.ncbi.nlm.nih.gov/gene/?term=4217 "ASK1, MAPKKK5, MEKK5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039467 4232 MEST http://www.ncbi.nlm.nih.gov/gene/?term=4232 PEG1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039468 4233 MET http://www.ncbi.nlm.nih.gov/gene/?term=4233 "AUTS9, DFNB97, HGFR, RCCP2, c-Met" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039469 4255 MGMT http://www.ncbi.nlm.nih.gov/gene/?term=4255 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039470 4255 MGMT http://www.ncbi.nlm.nih.gov/gene/?term=4255 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039471 4259 MGST3 http://www.ncbi.nlm.nih.gov/gene/?term=4259 GST-III mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039472 4281 MID1 http://www.ncbi.nlm.nih.gov/gene/?term=4281 "BBBG1, FXY, GBBB1, MIDIN, OGS1, OS, OSX, RNF59, TRIM18, XPRF, ZNFXY" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039473 4289 MKLN1 http://www.ncbi.nlm.nih.gov/gene/?term=4289 TWA2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039474 4289 MKLN1 http://www.ncbi.nlm.nih.gov/gene/?term=4289 TWA2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039475 4292 MLH1 http://www.ncbi.nlm.nih.gov/gene/?term=4292 "COCA2, FCC2, HNPCC, HNPCC2, hMLH1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039476 4292 MLH1 http://www.ncbi.nlm.nih.gov/gene/?term=4292 "COCA2, FCC2, HNPCC, HNPCC2, hMLH1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039477 4299 AFF1 http://www.ncbi.nlm.nih.gov/gene/?term=4299 "AF4, MLLT2, PBM1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039478 4299 AFF1 http://www.ncbi.nlm.nih.gov/gene/?term=4299 "AF4, MLLT2, PBM1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039479 4300 MLLT3 http://www.ncbi.nlm.nih.gov/gene/?term=4300 "AF9, YEATS3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039480 4300 MLLT3 http://www.ncbi.nlm.nih.gov/gene/?term=4300 "AF9, YEATS3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039481 4306 NR3C2 http://www.ncbi.nlm.nih.gov/gene/?term=4306 "MCR, MLR, MRVIT, NR3C2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039482 4306 NR3C2 http://www.ncbi.nlm.nih.gov/gene/?term=4306 "MCR, MLR, MRVIT, NR3C2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039483 4331 MNAT1 http://www.ncbi.nlm.nih.gov/gene/?term=4331 "CAP35, MAT1, RNF66, TFB3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039484 4350 MPG http://www.ncbi.nlm.nih.gov/gene/?term=4350 "AAG, ADPG, APNG, CRA36.1, MDG, Mid1, PIG11, PIG16, anpg" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039485 4350 MPG http://www.ncbi.nlm.nih.gov/gene/?term=4350 "AAG, ADPG, APNG, CRA36.1, MDG, Mid1, PIG11, PIG16, anpg" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039486 4353 MPO http://www.ncbi.nlm.nih.gov/gene/?term=4353 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039487 4353 MPO http://www.ncbi.nlm.nih.gov/gene/?term=4353 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039488 440957 SMIM4 http://www.ncbi.nlm.nih.gov/gene/?term=440957 C3orf78 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039489 440957 SMIM4 http://www.ncbi.nlm.nih.gov/gene/?term=440957 C3orf78 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039490 442582 STAG3L2 http://www.ncbi.nlm.nih.gov/gene/?term=442582 "STAG3L1, STAG3L3, STAG3L2P" lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00039491 442582 STAG3L2 http://www.ncbi.nlm.nih.gov/gene/?term=442582 "STAG3L1, STAG3L3, STAG3L2P" lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00039492 444 ASPH http://www.ncbi.nlm.nih.gov/gene/?term=444 "AAH, BAH, CASQ2BP1, FDLAB, HAAH, JCTN, junctin" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039493 445 ASS1 http://www.ncbi.nlm.nih.gov/gene/?term=445 "ASS, CTLN1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039494 445 ASS1 http://www.ncbi.nlm.nih.gov/gene/?term=445 "ASS, CTLN1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039495 4482 MSRA http://www.ncbi.nlm.nih.gov/gene/?term=4482 PMSR mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039496 4482 MSRA http://www.ncbi.nlm.nih.gov/gene/?term=4482 PMSR mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039497 4507 MTAP http://www.ncbi.nlm.nih.gov/gene/?term=4507 "BDMF, DMSFH, DMSMFH, HEL-249, LGMBF, MSAP, c86fus" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039498 4507 MTAP http://www.ncbi.nlm.nih.gov/gene/?term=4507 "BDMF, DMSFH, DMSMFH, HEL-249, LGMBF, MSAP, c86fus" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039499 4542 MYO1F http://www.ncbi.nlm.nih.gov/gene/?term=4542 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039500 4542 MYO1F http://www.ncbi.nlm.nih.gov/gene/?term=4542 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039501 4552 MTRR http://www.ncbi.nlm.nih.gov/gene/?term=4552 "MSR, cblE" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039502 4627 MYH9 http://www.ncbi.nlm.nih.gov/gene/?term=4627 "BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039503 4627 MYH9 http://www.ncbi.nlm.nih.gov/gene/?term=4627 "BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039504 4629 MYH11 http://www.ncbi.nlm.nih.gov/gene/?term=4629 "AAT4, FAA4, SMHC, SMMHC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039505 4651 MYO10 http://www.ncbi.nlm.nih.gov/gene/?term=4651 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039506 4651 MYO10 http://www.ncbi.nlm.nih.gov/gene/?term=4651 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039507 4659 PPP1R12A http://www.ncbi.nlm.nih.gov/gene/?term=4659 "M130, MBS, MYPT1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039508 4660 PPP1R12B http://www.ncbi.nlm.nih.gov/gene/?term=4660 "MYPT2, PP1bp55" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039509 4660 PPP1R12B http://www.ncbi.nlm.nih.gov/gene/?term=4660 "MYPT2, PP1bp55" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039510 4666 NACA http://www.ncbi.nlm.nih.gov/gene/?term=4666 "HSD48, NAC-alpha1, skNAC, NACA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039511 4666 NACA http://www.ncbi.nlm.nih.gov/gene/?term=4666 "HSD48, NAC-alpha1, skNAC, NACA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039512 4670 HNRNPM http://www.ncbi.nlm.nih.gov/gene/?term=4670 "CEAR4, HNRPM, HNRPM4, HTGR1, NAGR1, hnRNP M, HNRNPM" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039513 4670 HNRNPM http://www.ncbi.nlm.nih.gov/gene/?term=4670 "CEAR4, HNRPM, HNRPM4, HTGR1, NAGR1, hnRNP M, HNRNPM" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039514 4678 NASP http://www.ncbi.nlm.nih.gov/gene/?term=4678 "FLB7527, HMDRA1, PRO1999" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039515 4678 NASP http://www.ncbi.nlm.nih.gov/gene/?term=4678 "FLB7527, HMDRA1, PRO1999" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039516 4684 NCAM1 http://www.ncbi.nlm.nih.gov/gene/?term=4684 "CD56, MSK39, NCAM" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039517 4684 NCAM1 http://www.ncbi.nlm.nih.gov/gene/?term=4684 "CD56, MSK39, NCAM" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039518 4685 NCAM2 http://www.ncbi.nlm.nih.gov/gene/?term=4685 NCAM21 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039519 4695 NDUFA2 http://www.ncbi.nlm.nih.gov/gene/?term=4695 "B8, CD14, CIB8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039520 4695 NDUFA2 http://www.ncbi.nlm.nih.gov/gene/?term=4695 "B8, CD14, CIB8" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039521 4705 NDUFA10 http://www.ncbi.nlm.nih.gov/gene/?term=4705 "CI-42KD, CI-42k" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039522 4705 NDUFA10 http://www.ncbi.nlm.nih.gov/gene/?term=4705 "CI-42KD, CI-42k" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039523 4716 NDUFB10 http://www.ncbi.nlm.nih.gov/gene/?term=4716 PDSW mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039524 4716 NDUFB10 http://www.ncbi.nlm.nih.gov/gene/?term=4716 PDSW mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039525 4719 NDUFS1 http://www.ncbi.nlm.nih.gov/gene/?term=4719 "CI-75Kd, CI-75k, PRO1304" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039526 4719 NDUFS1 http://www.ncbi.nlm.nih.gov/gene/?term=4719 "CI-75Kd, CI-75k, PRO1304" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039527 4725 NDUFS5 http://www.ncbi.nlm.nih.gov/gene/?term=4725 "CI-15k, CI15K" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039528 473 RERE http://www.ncbi.nlm.nih.gov/gene/?term=473 "ARG, ARP, ATN1L, DNB1, NEDBEH" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039529 473 RERE http://www.ncbi.nlm.nih.gov/gene/?term=473 "ARG, ARP, ATN1L, DNB1, NEDBEH" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039530 4733 DRG1 http://www.ncbi.nlm.nih.gov/gene/?term=4733 NEDD3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039531 4735 SEPT2 http://www.ncbi.nlm.nih.gov/gene/?term=4735 "DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039532 4739 NEDD9 http://www.ncbi.nlm.nih.gov/gene/?term=4739 "CAS-L, CAS2, CASL, CASS2, HEF1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039533 4739 NEDD9 http://www.ncbi.nlm.nih.gov/gene/?term=4739 "CAS-L, CAS2, CASL, CASS2, HEF1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039534 4771 NF2 http://www.ncbi.nlm.nih.gov/gene/?term=4771 "ACN, BANF, SCH" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039535 4771 NF2 http://www.ncbi.nlm.nih.gov/gene/?term=4771 "ACN, BANF, SCH" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039536 4774 NFIA http://www.ncbi.nlm.nih.gov/gene/?term=4774 "BRMUTD, CTF, NF-I/A, NF1-A, NFI-A, NFI-L" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039537 4774 NFIA http://www.ncbi.nlm.nih.gov/gene/?term=4774 "BRMUTD, CTF, NF-I/A, NF1-A, NFI-A, NFI-L" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039538 4781 NFIB http://www.ncbi.nlm.nih.gov/gene/?term=4781 "CTF, HMGIC/NFIB, NF-I/B, NF1-B, NFI-B, NFI-RED2, NFIB3, NFIB" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039539 4784 NFIX http://www.ncbi.nlm.nih.gov/gene/?term=4784 "CTF, MRSHSS, NF-I/X, NF1-X, NF1A, SOTOS2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039540 4784 NFIX http://www.ncbi.nlm.nih.gov/gene/?term=4784 "CTF, MRSHSS, NF-I/X, NF1-X, NF1A, SOTOS2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039541 4799 NFX1 http://www.ncbi.nlm.nih.gov/gene/?term=4799 "NFX2, TEG-42, Tex42" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039542 4802 NFYC http://www.ncbi.nlm.nih.gov/gene/?term=4802 "CBF-C, CBFC, H1TF2A, HAP5, HSM, NF-YC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039543 4802 NFYC http://www.ncbi.nlm.nih.gov/gene/?term=4802 "CBF-C, CBFC, H1TF2A, HAP5, HSM, NF-YC" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039544 4809 SNU13 http://www.ncbi.nlm.nih.gov/gene/?term=4809 "15.5K, FA-1, FA1, NHP2L1, NHPX, OTK27, SNRNP15-5, SPAG12, SSFA1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039545 4809 SNU13 http://www.ncbi.nlm.nih.gov/gene/?term=4809 "15.5K, FA-1, FA1, NHP2L1, NHPX, OTK27, SNRNP15-5, SPAG12, SSFA1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039546 4814 NINJ1 http://www.ncbi.nlm.nih.gov/gene/?term=4814 "NIN1, NINJURIN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039547 4814 NINJ1 http://www.ncbi.nlm.nih.gov/gene/?term=4814 "NIN1, NINJURIN" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039548 483 ATP1B3 http://www.ncbi.nlm.nih.gov/gene/?term=483 "ATPB-3, CD298" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039549 483 ATP1B3 http://www.ncbi.nlm.nih.gov/gene/?term=483 "ATPB-3, CD298" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039550 4837 NNMT http://www.ncbi.nlm.nih.gov/gene/?term=4837 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039551 4837 NNMT http://www.ncbi.nlm.nih.gov/gene/?term=4837 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039552 4848 CNOT2 http://www.ncbi.nlm.nih.gov/gene/?term=4848 "CDC36, HSPC131, NOT2, NOT2H" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039553 4848 CNOT2 http://www.ncbi.nlm.nih.gov/gene/?term=4848 "CDC36, HSPC131, NOT2, NOT2H" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039554 4850 CNOT4 http://www.ncbi.nlm.nih.gov/gene/?term=4850 "CLONE243, NOT4, NOT4H" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039555 488 ATP2A2 http://www.ncbi.nlm.nih.gov/gene/?term=488 "ATP2B, DAR, DD, SERCA2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039556 488 ATP2A2 http://www.ncbi.nlm.nih.gov/gene/?term=488 "ATP2B, DAR, DD, SERCA2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039557 490 ATP2B1 http://www.ncbi.nlm.nih.gov/gene/?term=490 "PMCA1, PMCA1kb" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039558 4919 ROR1 http://www.ncbi.nlm.nih.gov/gene/?term=4919 "NTRKR1, dJ537F10.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039559 4919 ROR1 http://www.ncbi.nlm.nih.gov/gene/?term=4919 "NTRKR1, dJ537F10.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039560 4927 NUP88 http://www.ncbi.nlm.nih.gov/gene/?term=4927 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039561 4929 NR4A2 http://www.ncbi.nlm.nih.gov/gene/?term=4929 "HZF-3, NOT, NURR1, RNR1, TINUR" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039562 4929 NR4A2 http://www.ncbi.nlm.nih.gov/gene/?term=4929 "HZF-3, NOT, NURR1, RNR1, TINUR" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039563 4947 OAZ2 http://www.ncbi.nlm.nih.gov/gene/?term=4947 AZ2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039564 4976 OPA1 http://www.ncbi.nlm.nih.gov/gene/?term=4976 "BERHS, MGM1, MTDPS14, NPG, NTG, largeG" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039565 4976 OPA1 http://www.ncbi.nlm.nih.gov/gene/?term=4976 "BERHS, MGM1, MTDPS14, NPG, NTG, largeG" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039566 5046 PCSK6 http://www.ncbi.nlm.nih.gov/gene/?term=5046 "PACE4, SPC4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039567 5046 PCSK6 http://www.ncbi.nlm.nih.gov/gene/?term=5046 "PACE4, SPC4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039568 5048 PAFAH1B1 http://www.ncbi.nlm.nih.gov/gene/?term=5048 "LIS1, LIS2, MDCR, MDS, NudF, PAFAH" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039569 50488 MINK1 http://www.ncbi.nlm.nih.gov/gene/?term=50488 "B55, MAP4K6, MINK, YSK2, ZC3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039570 50515 CHST11 http://www.ncbi.nlm.nih.gov/gene/?term=50515 "C4ST, C4ST-1, C4ST1, HSA269537" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039571 50515 CHST11 http://www.ncbi.nlm.nih.gov/gene/?term=50515 "C4ST, C4ST-1, C4ST1, HSA269537" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039572 5058 PAK1 http://www.ncbi.nlm.nih.gov/gene/?term=5058 PAKalpha mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039573 50618 ITSN2 http://www.ncbi.nlm.nih.gov/gene/?term=50618 "PRO2015, SH3D1B, SH3P18, SWA, SWAP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039574 50640 PNPLA8 http://www.ncbi.nlm.nih.gov/gene/?term=50640 "IPLA2-2, IPLA2G, MMLA, PNPLA-gamma, iPLA2gamma" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039575 50650 ARHGEF3 http://www.ncbi.nlm.nih.gov/gene/?term=50650 "GEF3, STA3, XPLN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039576 50650 ARHGEF3 http://www.ncbi.nlm.nih.gov/gene/?term=50650 "GEF3, STA3, XPLN" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039577 5066 PAM http://www.ncbi.nlm.nih.gov/gene/?term=5066 "PAL, PHM" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039578 5066 PAM http://www.ncbi.nlm.nih.gov/gene/?term=5066 "PAL, PHM" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039579 5069 PAPPA http://www.ncbi.nlm.nih.gov/gene/?term=5069 "ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A1, PAPPA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039580 5069 PAPPA http://www.ncbi.nlm.nih.gov/gene/?term=5069 "ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A1, PAPPA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039581 50717 DCAF8 http://www.ncbi.nlm.nih.gov/gene/?term=50717 "GAN2, H326, WDR42A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039582 50717 DCAF8 http://www.ncbi.nlm.nih.gov/gene/?term=50717 "GAN2, H326, WDR42A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039583 50807 ASAP1 http://www.ncbi.nlm.nih.gov/gene/?term=50807 "AMAP1, CENTB4, DDEF1, PAG2, PAP, ZG14P" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039584 50807 ASAP1 http://www.ncbi.nlm.nih.gov/gene/?term=50807 "AMAP1, CENTB4, DDEF1, PAG2, PAP, ZG14P" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039585 50810 HDGFL3 http://www.ncbi.nlm.nih.gov/gene/?term=50810 "CGI-142, HDGF-2, HDGF2, HDGFRP3, HRP-3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039586 50863 NTM http://www.ncbi.nlm.nih.gov/gene/?term=50863 "CEPU-1, HNT, IGLON2, NTRI" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039587 50863 NTM http://www.ncbi.nlm.nih.gov/gene/?term=50863 "CEPU-1, HNT, IGLON2, NTRI" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039588 5087 PBX1 http://www.ncbi.nlm.nih.gov/gene/?term=5087 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039589 5087 PBX1 http://www.ncbi.nlm.nih.gov/gene/?term=5087 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039590 5090 PBX3 http://www.ncbi.nlm.nih.gov/gene/?term=5090 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039591 5090 PBX3 http://www.ncbi.nlm.nih.gov/gene/?term=5090 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039592 5094 PCBP2 http://www.ncbi.nlm.nih.gov/gene/?term=5094 "HNRNPE2, HNRPE2, hnRNP-E2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039593 5095 PCCA http://www.ncbi.nlm.nih.gov/gene/?term=5095 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039594 5095 PCCA http://www.ncbi.nlm.nih.gov/gene/?term=5095 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039595 51010 EXOSC3 http://www.ncbi.nlm.nih.gov/gene/?term=51010 "CGI-102, PCH1B, RRP40, Rrp40p, bA3J10.7, hRrp-40, p10" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039596 51053 GMNN http://www.ncbi.nlm.nih.gov/gene/?term=51053 "Gem, MGORS6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039597 51053 GMNN http://www.ncbi.nlm.nih.gov/gene/?term=51053 "Gem, MGORS6" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039598 51065 RPS27L http://www.ncbi.nlm.nih.gov/gene/?term=51065 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039599 51065 RPS27L http://www.ncbi.nlm.nih.gov/gene/?term=51065 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039600 51069 MRPL2 http://www.ncbi.nlm.nih.gov/gene/?term=51069 "CGI-22, MRP-L14, RPML14" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039601 51069 MRPL2 http://www.ncbi.nlm.nih.gov/gene/?term=51069 "CGI-22, MRP-L14, RPML14" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039602 51072 MEMO1 http://www.ncbi.nlm.nih.gov/gene/?term=51072 "C2orf4, CGI-27, MEMO, NS5ATP7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039603 51072 MEMO1 http://www.ncbi.nlm.nih.gov/gene/?term=51072 "C2orf4, CGI-27, MEMO, NS5ATP7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039604 51076 CUTC http://www.ncbi.nlm.nih.gov/gene/?term=51076 CGI-32 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039605 51076 CUTC http://www.ncbi.nlm.nih.gov/gene/?term=51076 CGI-32 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039606 51088 KLHL5 http://www.ncbi.nlm.nih.gov/gene/?term=51088 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039607 51112 TRAPPC12 http://www.ncbi.nlm.nih.gov/gene/?term=51112 "CGI-87, TTC-15, TTC15" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039608 51112 TRAPPC12 http://www.ncbi.nlm.nih.gov/gene/?term=51112 "CGI-87, TTC-15, TTC15" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039609 51115 RMDN1 http://www.ncbi.nlm.nih.gov/gene/?term=51115 "CGI-90, FAM82B, RMD-1, RMD1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039610 51115 RMDN1 http://www.ncbi.nlm.nih.gov/gene/?term=51115 "CGI-90, FAM82B, RMD-1, RMD1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039611 51124 IER3IP1 http://www.ncbi.nlm.nih.gov/gene/?term=51124 "MEDS, HSPC039, PRO2309" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039612 51124 IER3IP1 http://www.ncbi.nlm.nih.gov/gene/?term=51124 "MEDS, HSPC039, PRO2309" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039613 51222 ZNF219 http://www.ncbi.nlm.nih.gov/gene/?term=51222 ZFP219 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039614 51222 ZNF219 http://www.ncbi.nlm.nih.gov/gene/?term=51222 ZFP219 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039615 51228 GLTP http://www.ncbi.nlm.nih.gov/gene/?term=51228 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039616 51228 GLTP http://www.ncbi.nlm.nih.gov/gene/?term=51228 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039617 51230 PHF20 http://www.ncbi.nlm.nih.gov/gene/?term=51230 "C20orf104, GLEA2, HCA58, NZF, TDRD20A, TZP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039618 51230 PHF20 http://www.ncbi.nlm.nih.gov/gene/?term=51230 "C20orf104, GLEA2, HCA58, NZF, TDRD20A, TZP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039619 51232 CRIM1 http://www.ncbi.nlm.nih.gov/gene/?term=51232 "CRIM-1, S52" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039620 51247 PAIP2 http://www.ncbi.nlm.nih.gov/gene/?term=51247 "PAIP-2A, PAIP2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039621 51247 PAIP2 http://www.ncbi.nlm.nih.gov/gene/?term=51247 "PAIP-2A, PAIP2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039622 51257 MARCH2 http://www.ncbi.nlm.nih.gov/gene/?term=51257 "HSPC240, MARCH-II, RNF172" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039623 51257 MARCH2 http://www.ncbi.nlm.nih.gov/gene/?term=51257 "HSPC240, MARCH-II, RNF172" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039624 51306 FAM13B http://www.ncbi.nlm.nih.gov/gene/?term=51306 "ARHGAP49, C5orf51, KHCHP, N61, FAM13B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039625 51312 SLC25A37 http://www.ncbi.nlm.nih.gov/gene/?term=51312 "HT015, MFRN, MFRN1, MSC, MSCP, PRO1278, PRO1584, PRO2217" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039626 51312 SLC25A37 http://www.ncbi.nlm.nih.gov/gene/?term=51312 "HT015, MFRN, MFRN1, MSC, MSCP, PRO1278, PRO1584, PRO2217" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039627 51315 KRCC1 http://www.ncbi.nlm.nih.gov/gene/?term=51315 CHBP2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039628 51317 PHF21A http://www.ncbi.nlm.nih.gov/gene/?term=51317 "BHC80, BM-006" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039629 51317 PHF21A http://www.ncbi.nlm.nih.gov/gene/?term=51317 "BHC80, BM-006" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039630 51319 RSRC1 http://www.ncbi.nlm.nih.gov/gene/?term=51319 "BM-011, SFRS21, SRrp53" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039631 51322 WAC http://www.ncbi.nlm.nih.gov/gene/?term=51322 "BM-016, DESSH, PRO1741, Wwp4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039632 51341 ZBTB7A http://www.ncbi.nlm.nih.gov/gene/?term=51341 "FBI-1, FBI1, LRF, TIP21, ZBTB7, ZNF857A, pokemon" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039633 51341 ZBTB7A http://www.ncbi.nlm.nih.gov/gene/?term=51341 "FBI-1, FBI1, LRF, TIP21, ZBTB7, ZNF857A, pokemon" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039634 51347 TAOK3 http://www.ncbi.nlm.nih.gov/gene/?term=51347 "DPK, JIK, MAP3K18, hKFC-A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039635 51347 TAOK3 http://www.ncbi.nlm.nih.gov/gene/?term=51347 "DPK, JIK, MAP3K18, hKFC-A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039636 51363 CHST15 http://www.ncbi.nlm.nih.gov/gene/?term=51363 "BRAG, GALNAC4S-6ST" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039637 51363 CHST15 http://www.ncbi.nlm.nih.gov/gene/?term=51363 "BRAG, GALNAC4S-6ST" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039638 51366 UBR5 http://www.ncbi.nlm.nih.gov/gene/?term=51366 "DD5, EDD, EDD1, HYD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039639 51366 UBR5 http://www.ncbi.nlm.nih.gov/gene/?term=51366 "DD5, EDD, EDD1, HYD" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039640 51379 CRLF3 http://www.ncbi.nlm.nih.gov/gene/?term=51379 "CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039641 51379 CRLF3 http://www.ncbi.nlm.nih.gov/gene/?term=51379 "CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039642 51382 ATP6V1D http://www.ncbi.nlm.nih.gov/gene/?term=51382 "ATP6M, VATD, VMA8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039643 51382 ATP6V1D http://www.ncbi.nlm.nih.gov/gene/?term=51382 "ATP6M, VATD, VMA8" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039644 5139 PDE3A http://www.ncbi.nlm.nih.gov/gene/?term=5139 "CGI-PDE, CGI-PDE A, CGI-PDE-A, HTNB" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039645 51397 COMMD10 http://www.ncbi.nlm.nih.gov/gene/?term=51397 PTD002 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039646 51397 COMMD10 http://www.ncbi.nlm.nih.gov/gene/?term=51397 PTD002 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039647 51422 PRKAG2 http://www.ncbi.nlm.nih.gov/gene/?term=51422 "AAKG, AAKG2, CMH6, H91620p, WPWS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039648 51422 PRKAG2 http://www.ncbi.nlm.nih.gov/gene/?term=51422 "AAKG, AAKG2, CMH6, H91620p, WPWS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039649 5144 PDE4D http://www.ncbi.nlm.nih.gov/gene/?term=5144 "ACRDYS2, DPDE3, HSPDE4D, PDE43N2, STRK1, PDE4D" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039650 5144 PDE4D http://www.ncbi.nlm.nih.gov/gene/?term=5144 "ACRDYS2, DPDE3, HSPDE4D, PDE43N2, STRK1, PDE4D" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039651 51441 YTHDF2 http://www.ncbi.nlm.nih.gov/gene/?term=51441 "CAHL, HGRG8, NY-REN-2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039652 51441 YTHDF2 http://www.ncbi.nlm.nih.gov/gene/?term=51441 "CAHL, HGRG8, NY-REN-2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039653 51455 REV1 http://www.ncbi.nlm.nih.gov/gene/?term=51455 "AIBP80L, REV1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039654 5146 PDE6C http://www.ncbi.nlm.nih.gov/gene/?term=5146 "ACHM5, COD4, PDEA2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039655 5146 PDE6C http://www.ncbi.nlm.nih.gov/gene/?term=5146 "ACHM5, COD4, PDEA2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039656 51496 CTDSPL2 http://www.ncbi.nlm.nih.gov/gene/?term=51496 "HSPC058, HSPC129" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039657 51497 NELFCD http://www.ncbi.nlm.nih.gov/gene/?term=51497 "HSPC130, NELF-C, NELF-D, TH1, TH1L" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039658 51497 NELFCD http://www.ncbi.nlm.nih.gov/gene/?term=51497 "HSPC130, NELF-C, NELF-D, TH1, TH1L" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039659 51507 RTFDC1 http://www.ncbi.nlm.nih.gov/gene/?term=51507 "C20orf43, CDAO5, HSPC164, SHUJUN-3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039660 51507 RTFDC1 http://www.ncbi.nlm.nih.gov/gene/?term=51507 "C20orf43, CDAO5, HSPC164, SHUJUN-3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039661 5152 PDE9A http://www.ncbi.nlm.nih.gov/gene/?term=5152 HSPDE9A2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039662 5152 PDE9A http://www.ncbi.nlm.nih.gov/gene/?term=5152 HSPDE9A2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039663 51586 MED15 http://www.ncbi.nlm.nih.gov/gene/?term=51586 "ARC105, CAG7A, CTG7A, PCQAP, TIG-1, TIG1, TNRC7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039664 51586 MED15 http://www.ncbi.nlm.nih.gov/gene/?term=51586 "ARC105, CAG7A, CTG7A, PCQAP, TIG-1, TIG1, TNRC7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039665 51592 TRIM33 http://www.ncbi.nlm.nih.gov/gene/?term=51592 "ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039666 5160 PDHA1 http://www.ncbi.nlm.nih.gov/gene/?term=5160 "PDHA, PDHAD, PDHCE1A, PHE1A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039667 5160 PDHA1 http://www.ncbi.nlm.nih.gov/gene/?term=5160 "PDHA, PDHAD, PDHCE1A, PHE1A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039668 51602 NOP58 http://www.ncbi.nlm.nih.gov/gene/?term=51602 "HSPC120, NOP5, NOP5/NOP58" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039669 51603 METTL13 http://www.ncbi.nlm.nih.gov/gene/?term=51603 "5630401D24Rik, CGI-01, KIAA0859, feat" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039670 51604 PIGT http://www.ncbi.nlm.nih.gov/gene/?term=51604 "CGI-06, MCAHS3, NDAP, PNH2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039671 51604 PIGT http://www.ncbi.nlm.nih.gov/gene/?term=51604 "CGI-06, MCAHS3, NDAP, PNH2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039672 51621 KLF13 http://www.ncbi.nlm.nih.gov/gene/?term=51621 "BTEB3, FKLF2, NSLP1, RFLAT-1, RFLAT1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039673 51621 KLF13 http://www.ncbi.nlm.nih.gov/gene/?term=51621 "BTEB3, FKLF2, NSLP1, RFLAT-1, RFLAT1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039674 51646 YPEL5 http://www.ncbi.nlm.nih.gov/gene/?term=51646 CGI-127 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039675 51663 ZFR http://www.ncbi.nlm.nih.gov/gene/?term=51663 "SPG711, ZFR" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039676 51663 ZFR http://www.ncbi.nlm.nih.gov/gene/?term=51663 "SPG711, ZFR" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039677 5168 ENPP2 http://www.ncbi.nlm.nih.gov/gene/?term=5168 "ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039678 5168 ENPP2 http://www.ncbi.nlm.nih.gov/gene/?term=5168 "ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039679 51701 NLK http://www.ncbi.nlm.nih.gov/gene/?term=51701 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039680 51704 GPRC5B http://www.ncbi.nlm.nih.gov/gene/?term=51704 "RAIG-2, RAIG2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039681 51704 GPRC5B http://www.ncbi.nlm.nih.gov/gene/?term=51704 "RAIG-2, RAIG2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039682 51741 WWOX http://www.ncbi.nlm.nih.gov/gene/?term=51741 "D16S432E, EIEE28, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039683 51742 ARID4B http://www.ncbi.nlm.nih.gov/gene/?term=51742 "BCAA, BRCAA1, RBBP1L1, RBP1L1, SAP180" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039684 51742 ARID4B http://www.ncbi.nlm.nih.gov/gene/?term=51742 "BCAA, BRCAA1, RBBP1L1, RBP1L1, SAP180" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039685 51762 RAB8B http://www.ncbi.nlm.nih.gov/gene/?term=51762 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039686 51762 RAB8B http://www.ncbi.nlm.nih.gov/gene/?term=51762 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039687 51773 RSF1 http://www.ncbi.nlm.nih.gov/gene/?term=51773 "HBXAP, RSF-1, XAP8, p325" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039688 5195 PEX14 http://www.ncbi.nlm.nih.gov/gene/?term=5195 "NAPP2, PBD13A, Pex14p, dJ734G22.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039689 5210 PFKFB4 http://www.ncbi.nlm.nih.gov/gene/?term=5210 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039690 5210 PFKFB4 http://www.ncbi.nlm.nih.gov/gene/?term=5210 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039691 5212 VIT http://www.ncbi.nlm.nih.gov/gene/?term=5212 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039692 5218 CDK14 http://www.ncbi.nlm.nih.gov/gene/?term=5218 "PFTAIRE1, PFTK1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039693 5218 CDK14 http://www.ncbi.nlm.nih.gov/gene/?term=5218 "PFTAIRE1, PFTK1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039694 523 ATP6V1A http://www.ncbi.nlm.nih.gov/gene/?term=523 "ARCL2D, ATP6A11, HO68, VA68, VPP2, Vma1, ATP6V1A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039695 5287 PIK3C2B http://www.ncbi.nlm.nih.gov/gene/?term=5287 C2-PI3K mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039696 5289 PIK3C3 http://www.ncbi.nlm.nih.gov/gene/?term=5289 "VPS34, Vps34, hVps34" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039697 5295 PIK3R1 http://www.ncbi.nlm.nih.gov/gene/?term=5295 "AGM7, GRB1, IMD36, p85, p85-ALPHA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039698 5295 PIK3R1 http://www.ncbi.nlm.nih.gov/gene/?term=5295 "AGM7, GRB1, IMD36, p85, p85-ALPHA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039699 5305 PIP4K2A http://www.ncbi.nlm.nih.gov/gene/?term=5305 "PI5P4KA, PIP5K2A, PIP5KII-alpha, PIP5KIIA, PIPK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039700 5305 PIP4K2A http://www.ncbi.nlm.nih.gov/gene/?term=5305 "PI5P4KA, PIP5K2A, PIP5KII-alpha, PIP5KIIA, PIPK" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039701 5311 PKD2 http://www.ncbi.nlm.nih.gov/gene/?term=5311 "APKD2, PC2, PKD4, Pc-2, TRPP2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039702 5311 PKD2 http://www.ncbi.nlm.nih.gov/gene/?term=5311 "APKD2, PC2, PKD4, Pc-2, TRPP2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039703 5321 PLA2G4A http://www.ncbi.nlm.nih.gov/gene/?term=5321 "PLA2G4, cPLA2, cPLA2-alpha" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039704 5321 PLA2G4A http://www.ncbi.nlm.nih.gov/gene/?term=5321 "PLA2G4, cPLA2, cPLA2-alpha" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039705 5336 PLCG2 http://www.ncbi.nlm.nih.gov/gene/?term=5336 "APLAID, FCAS3, PLC-IV, PLC-gamma-2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039706 5336 PLCG2 http://www.ncbi.nlm.nih.gov/gene/?term=5336 "APLAID, FCAS3, PLC-IV, PLC-gamma-2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039707 53371 NUP54 http://www.ncbi.nlm.nih.gov/gene/?term=53371 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039708 53371 NUP54 http://www.ncbi.nlm.nih.gov/gene/?term=53371 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039709 535 ATP6V0A1 http://www.ncbi.nlm.nih.gov/gene/?term=535 "ATP6N1, ATP6N1A, Stv1, VPP1, Vph1, a1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039710 5359 PLSCR1 http://www.ncbi.nlm.nih.gov/gene/?term=5359 MMTRA1B mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039711 53624 Cldn7 http://www.ncbi.nlm.nih.gov/gene/?term=53624 mRNA Mus musculus 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039712 53624 Cldn7 http://www.ncbi.nlm.nih.gov/gene/?term=53624 mRNA Mus musculus 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039713 5373 PMM2 http://www.ncbi.nlm.nih.gov/gene/?term=5373 "CDG1, CDG1a, CDGS, PMI, PMI1, PMM 2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039714 5378 PMS1 http://www.ncbi.nlm.nih.gov/gene/?term=5378 "HNPCC3, MLH2, PMSL1, hPMS1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039715 5378 PMS1 http://www.ncbi.nlm.nih.gov/gene/?term=5378 "HNPCC3, MLH2, PMSL1, hPMS1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039716 5396 PRRX1 http://www.ncbi.nlm.nih.gov/gene/?term=5396 "AGOTC, PHOX1, PMX1, PRX-1, PRX1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039717 5396 PRRX1 http://www.ncbi.nlm.nih.gov/gene/?term=5396 "AGOTC, PHOX1, PMX1, PRX-1, PRX1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039718 54020 SLC37A1 http://www.ncbi.nlm.nih.gov/gene/?term=54020 G3PP mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039719 5423 POLB http://www.ncbi.nlm.nih.gov/gene/?term=5423 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039720 5423 POLB http://www.ncbi.nlm.nih.gov/gene/?term=5423 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039721 5425 POLD2 http://www.ncbi.nlm.nih.gov/gene/?term=5425 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039722 5425 POLD2 http://www.ncbi.nlm.nih.gov/gene/?term=5425 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039723 5427 POLE2 http://www.ncbi.nlm.nih.gov/gene/?term=5427 DPE2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039724 5427 POLE2 http://www.ncbi.nlm.nih.gov/gene/?term=5427 DPE2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039725 5429 POLH http://www.ncbi.nlm.nih.gov/gene/?term=5429 "RAD30, RAD30A, XP-V, XPV" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039726 54420 Cldn8 http://www.ncbi.nlm.nih.gov/gene/?term=54420 AI648025 mRNA Mus musculus 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039727 54420 Cldn8 http://www.ncbi.nlm.nih.gov/gene/?term=54420 AI648025 mRNA Mus musculus 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039728 54434 SSH1 http://www.ncbi.nlm.nih.gov/gene/?term=54434 SSH1L mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039729 54434 SSH1 http://www.ncbi.nlm.nih.gov/gene/?term=54434 SSH1L mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039730 54443 ANLN http://www.ncbi.nlm.nih.gov/gene/?term=54443 "FSGS8, Scraps, scra" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039731 5445 PON2 http://www.ncbi.nlm.nih.gov/gene/?term=5445 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039732 5445 PON2 http://www.ncbi.nlm.nih.gov/gene/?term=5445 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039733 54453 RIN2 http://www.ncbi.nlm.nih.gov/gene/?term=54453 "MACS, RASSF4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039734 54453 RIN2 http://www.ncbi.nlm.nih.gov/gene/?term=54453 "MACS, RASSF4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039735 54476 RNF216 http://www.ncbi.nlm.nih.gov/gene/?term=54476 "CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039736 54476 RNF216 http://www.ncbi.nlm.nih.gov/gene/?term=54476 "CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039737 54477 PLEKHA5 http://www.ncbi.nlm.nih.gov/gene/?term=54477 "PEPP-2, PEPP2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039738 54477 PLEKHA5 http://www.ncbi.nlm.nih.gov/gene/?term=54477 "PEPP-2, PEPP2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039739 54495 TMX3 http://www.ncbi.nlm.nih.gov/gene/?term=54495 "PDIA13, TXNDC10" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039740 54495 TMX3 http://www.ncbi.nlm.nih.gov/gene/?term=54495 "PDIA13, TXNDC10" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039741 54498 SMOX http://www.ncbi.nlm.nih.gov/gene/?term=54498 "C20orf16, PAO, PAO-1, PAO1, PAOH, PAOH1, SMO" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039742 54498 SMOX http://www.ncbi.nlm.nih.gov/gene/?term=54498 "C20orf16, PAO, PAO-1, PAO1, PAOH, PAOH1, SMO" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039743 545 ATR http://www.ncbi.nlm.nih.gov/gene/?term=545 "FCTCS, FRP1, MEC1, SCKL, SCKL1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039744 545 ATR http://www.ncbi.nlm.nih.gov/gene/?term=545 "FCTCS, FRP1, MEC1, SCKL, SCKL1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039745 54502 RBM47 http://www.ncbi.nlm.nih.gov/gene/?term=54502 NET18 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039746 54502 RBM47 http://www.ncbi.nlm.nih.gov/gene/?term=54502 NET18 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039747 54504 CPVL http://www.ncbi.nlm.nih.gov/gene/?term=54504 HVLP mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039748 54517 PUS7 http://www.ncbi.nlm.nih.gov/gene/?term=54517 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039749 54536 EXOC6 http://www.ncbi.nlm.nih.gov/gene/?term=54536 "EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039750 54536 EXOC6 http://www.ncbi.nlm.nih.gov/gene/?term=54536 "EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039751 54540 FAM193B http://www.ncbi.nlm.nih.gov/gene/?term=54540 IRIZIO mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039752 54540 FAM193B http://www.ncbi.nlm.nih.gov/gene/?term=54540 IRIZIO mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039753 54566 EPB41L4B http://www.ncbi.nlm.nih.gov/gene/?term=54566 "CG1, EHM2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039754 54566 EPB41L4B http://www.ncbi.nlm.nih.gov/gene/?term=54566 "CG1, EHM2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039755 54617 INO80 http://www.ncbi.nlm.nih.gov/gene/?term=54617 "INO80A, INOC1, hINO80" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039756 5464 PPA1 http://www.ncbi.nlm.nih.gov/gene/?term=5464 "HEL-S-66p, IOPPP, PP, PP1, SID6-8061" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039757 54677 CROT http://www.ncbi.nlm.nih.gov/gene/?term=54677 COT mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039758 54677 CROT http://www.ncbi.nlm.nih.gov/gene/?term=54677 COT mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039759 5468 PPARG http://www.ncbi.nlm.nih.gov/gene/?term=5468 "CIMT1, GLM1, NR1C31, PPARG2, PPARgamma, PPARG" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039760 5468 PPARG http://www.ncbi.nlm.nih.gov/gene/?term=5468 "CIMT1, GLM1, NR1C31, PPARG2, PPARgamma, PPARG" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039761 5471 PPAT http://www.ncbi.nlm.nih.gov/gene/?term=5471 "ATASE, GPAT, PRAT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039762 54715 RBFOX1 http://www.ncbi.nlm.nih.gov/gene/?term=54715 "2BP1, A2BP1, FOX-1, FOX1, HRNBP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039763 54715 RBFOX1 http://www.ncbi.nlm.nih.gov/gene/?term=54715 "2BP1, A2BP1, FOX-1, FOX1, HRNBP1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039764 54726 OTUD4 http://www.ncbi.nlm.nih.gov/gene/?term=54726 "DUBA6, HIN1, HSHIN1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039765 54749 EPDR1 http://www.ncbi.nlm.nih.gov/gene/?term=54749 "EPDR, MERP-1, MERP1, UCC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039766 54751 FBLIM1 http://www.ncbi.nlm.nih.gov/gene/?term=54751 "CAL, FBLP-1, FBLP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039767 54751 FBLIM1 http://www.ncbi.nlm.nih.gov/gene/?term=54751 "CAL, FBLP-1, FBLP1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039768 54764 ZRANB1 http://www.ncbi.nlm.nih.gov/gene/?term=54764 TRABID mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039769 54764 ZRANB1 http://www.ncbi.nlm.nih.gov/gene/?term=54764 TRABID mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039770 54765 TRIM44 http://www.ncbi.nlm.nih.gov/gene/?term=54765 "AN3, DIPB, HSA249128, MC7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039771 54765 TRIM44 http://www.ncbi.nlm.nih.gov/gene/?term=54765 "AN3, DIPB, HSA249128, MC7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039772 54776 PPP1R12C http://www.ncbi.nlm.nih.gov/gene/?term=54776 "AAVS1, LENG3, MBS85, p84, p85" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039773 54776 PPP1R12C http://www.ncbi.nlm.nih.gov/gene/?term=54776 "AAVS1, LENG3, MBS85, p84, p85" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039774 54778 RNF111 http://www.ncbi.nlm.nih.gov/gene/?term=54778 "ARK, hRNF111" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039775 54778 RNF111 http://www.ncbi.nlm.nih.gov/gene/?term=54778 "ARK, hRNF111" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039776 54796 BNC2 http://www.ncbi.nlm.nih.gov/gene/?term=54796 BSN2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039777 54800 KLHL24 http://www.ncbi.nlm.nih.gov/gene/?term=54800 "DRE1, EBSSH, KRIP6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039778 54800 KLHL24 http://www.ncbi.nlm.nih.gov/gene/?term=54800 "DRE1, EBSSH, KRIP6" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039779 54805 CNNM2 http://www.ncbi.nlm.nih.gov/gene/?term=54805 "ACDP2, HOMG6, HOMGSMR" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039780 54806 AHI1 http://www.ncbi.nlm.nih.gov/gene/?term=54806 "AHI-1, JBTS3, ORF1, dJ71N10.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039781 54806 AHI1 http://www.ncbi.nlm.nih.gov/gene/?term=54806 "AHI-1, JBTS3, ORF1, dJ71N10.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039782 54808 DYM http://www.ncbi.nlm.nih.gov/gene/?term=54808 "DMC, SMC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039783 54808 DYM http://www.ncbi.nlm.nih.gov/gene/?term=54808 "DMC, SMC" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039784 54812 AFTPH http://www.ncbi.nlm.nih.gov/gene/?term=54812 Nbla10388 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039785 54815 GATAD2A http://www.ncbi.nlm.nih.gov/gene/?term=54815 p66alpha mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039786 54815 GATAD2A http://www.ncbi.nlm.nih.gov/gene/?term=54815 p66alpha mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039787 54819 ZCCHC10 http://www.ncbi.nlm.nih.gov/gene/?term=54819 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039788 54819 ZCCHC10 http://www.ncbi.nlm.nih.gov/gene/?term=54819 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039789 54828 BCAS3 http://www.ncbi.nlm.nih.gov/gene/?term=54828 "GAOB1, MAAB" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039790 54828 BCAS3 http://www.ncbi.nlm.nih.gov/gene/?term=54828 "GAOB1, MAAB" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039791 54840 APTX http://www.ncbi.nlm.nih.gov/gene/?term=54840 "AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039792 54872 PIGG http://www.ncbi.nlm.nih.gov/gene/?term=54872 "GPI7, LAS21, MRT53, PRO4405, RLGS1930" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039793 54873 PALMD http://www.ncbi.nlm.nih.gov/gene/?term=54873 "C1orf11, PALML" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039794 54875 CNTLN http://www.ncbi.nlm.nih.gov/gene/?term=54875 "C9orf101, C9orf39, bA340N12.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039795 54875 CNTLN http://www.ncbi.nlm.nih.gov/gene/?term=54875 "C9orf101, C9orf39, bA340N12.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039796 54880 BCOR http://www.ncbi.nlm.nih.gov/gene/?term=54880 "ANOP2, MAA2, MCOPS2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039797 54880 BCOR http://www.ncbi.nlm.nih.gov/gene/?term=54880 "ANOP2, MAA2, MCOPS2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039798 54893 MTMR10 http://www.ncbi.nlm.nih.gov/gene/?term=54893 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039799 54894 RNF43 http://www.ncbi.nlm.nih.gov/gene/?term=54894 "RNF124, SSPCS, URCC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039800 54894 RNF43 http://www.ncbi.nlm.nih.gov/gene/?term=54894 "RNF124, SSPCS, URCC" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039801 54897 CASZ1 http://www.ncbi.nlm.nih.gov/gene/?term=54897 "CAS11, CST, SRG, ZNF693, dJ734G22.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039802 54897 CASZ1 http://www.ncbi.nlm.nih.gov/gene/?term=54897 "CAS11, CST, SRG, ZNF693, dJ734G22.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039803 549 AUH http://www.ncbi.nlm.nih.gov/gene/?term=549 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039804 54901 CDKAL1 http://www.ncbi.nlm.nih.gov/gene/?term=54901 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039805 54902 TTC19 http://www.ncbi.nlm.nih.gov/gene/?term=54902 "2010204O13Rik, MC3DN2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039806 54902 TTC19 http://www.ncbi.nlm.nih.gov/gene/?term=54902 "2010204O13Rik, MC3DN2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039807 54914 FOCAD http://www.ncbi.nlm.nih.gov/gene/?term=54914 KIAA1797 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039808 54914 FOCAD http://www.ncbi.nlm.nih.gov/gene/?term=54914 KIAA1797 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039809 54927 CHCHD3 http://www.ncbi.nlm.nih.gov/gene/?term=54927 "MINOS3, Mic19, PPP1R22" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039810 54927 CHCHD3 http://www.ncbi.nlm.nih.gov/gene/?term=54927 "MINOS3, Mic19, PPP1R22" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039811 54947 LPCAT2 http://www.ncbi.nlm.nih.gov/gene/?term=54947 "AGPAT11, AYTL1, LysoPAFAT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039812 5496 PPM1G http://www.ncbi.nlm.nih.gov/gene/?term=5496 "PP2CG, PP2CGAMMA, PPP2CG" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039813 5496 PPM1G http://www.ncbi.nlm.nih.gov/gene/?term=5496 "PP2CG, PP2CGAMMA, PPP2CG" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039814 54995 OXSM http://www.ncbi.nlm.nih.gov/gene/?term=54995 "CEM1, FASN2D, KASI, KS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039815 54995 OXSM http://www.ncbi.nlm.nih.gov/gene/?term=54995 "CEM1, FASN2D, KASI, KS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039816 55002 TMCO3 http://www.ncbi.nlm.nih.gov/gene/?term=55002 C13orf11 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039817 55002 TMCO3 http://www.ncbi.nlm.nih.gov/gene/?term=55002 C13orf11 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039818 55003 PAK1IP1 http://www.ncbi.nlm.nih.gov/gene/?term=55003 "MAK11, PIP1, WDR84, bA421M1.5, hPIP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039819 55003 PAK1IP1 http://www.ncbi.nlm.nih.gov/gene/?term=55003 "MAK11, PIP1, WDR84, bA421M1.5, hPIP1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039820 55022 PID1 http://www.ncbi.nlm.nih.gov/gene/?term=55022 "HMFN2073, NYGGF4, P-CLI1, PCLI1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039821 55022 PID1 http://www.ncbi.nlm.nih.gov/gene/?term=55022 "HMFN2073, NYGGF4, P-CLI1, PCLI1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039822 55030 FBXO34 http://www.ncbi.nlm.nih.gov/gene/?term=55030 "CGI-301, Fbx34" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039823 55031 USP47 http://www.ncbi.nlm.nih.gov/gene/?term=55031 TRFP mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039824 55031 USP47 http://www.ncbi.nlm.nih.gov/gene/?term=55031 TRFP mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039825 55034 MOCOS http://www.ncbi.nlm.nih.gov/gene/?term=55034 "HMCS, MCS, MOS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039826 55034 MOCOS http://www.ncbi.nlm.nih.gov/gene/?term=55034 "HMCS, MCS, MOS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039827 55040 EPN3 http://www.ncbi.nlm.nih.gov/gene/?term=55040 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039828 55040 EPN3 http://www.ncbi.nlm.nih.gov/gene/?term=55040 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039829 55071 C9orf40 http://www.ncbi.nlm.nih.gov/gene/?term=55071 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039830 55075 UACA http://www.ncbi.nlm.nih.gov/gene/?term=55075 NUCLING mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039831 55095 SAMD4B http://www.ncbi.nlm.nih.gov/gene/?term=55095 "SMGB, Smaug2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039832 55095 SAMD4B http://www.ncbi.nlm.nih.gov/gene/?term=55095 "SMGB, Smaug2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039833 5510 PPP1R7 http://www.ncbi.nlm.nih.gov/gene/?term=5510 SDS22 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039834 5510 PPP1R7 http://www.ncbi.nlm.nih.gov/gene/?term=5510 SDS22 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039835 55100 WDR70 http://www.ncbi.nlm.nih.gov/gene/?term=55100 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039836 55103 RALGPS2 http://www.ncbi.nlm.nih.gov/gene/?term=55103 dJ595C2.1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039837 55103 RALGPS2 http://www.ncbi.nlm.nih.gov/gene/?term=55103 dJ595C2.1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039838 55105 GPATCH2 http://www.ncbi.nlm.nih.gov/gene/?term=55105 "CT110, GPATC2, PPP1R30, Pfa1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039839 55107 ANO1 http://www.ncbi.nlm.nih.gov/gene/?term=55107 "DOG1, ORAOV2, TAOS2, TMEM16A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039840 55107 ANO1 http://www.ncbi.nlm.nih.gov/gene/?term=55107 "DOG1, ORAOV2, TAOS2, TMEM16A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039841 55112 WDR60 http://www.ncbi.nlm.nih.gov/gene/?term=55112 "FAP163, SRPS6, SRTD8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039842 55129 ANO10 http://www.ncbi.nlm.nih.gov/gene/?term=55129 "SCAR10, TMEM16K" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039843 55132 LARP1B http://www.ncbi.nlm.nih.gov/gene/?term=55132 LARP2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039844 55144 LRRC8D http://www.ncbi.nlm.nih.gov/gene/?term=55144 LRRC5 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039845 55160 ARHGEF10L http://www.ncbi.nlm.nih.gov/gene/?term=55160 GrinchGEF mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039846 55160 ARHGEF10L http://www.ncbi.nlm.nih.gov/gene/?term=55160 GrinchGEF mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039847 55164 SHQ1 http://www.ncbi.nlm.nih.gov/gene/?term=55164 "GRIM-1, Shq1p" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039848 55164 SHQ1 http://www.ncbi.nlm.nih.gov/gene/?term=55164 "GRIM-1, Shq1p" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039849 55182 RNF220 http://www.ncbi.nlm.nih.gov/gene/?term=55182 C1orf164 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039850 55182 RNF220 http://www.ncbi.nlm.nih.gov/gene/?term=55182 C1orf164 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039851 55183 RIF1 http://www.ncbi.nlm.nih.gov/gene/?term=55183 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039852 55184 DZANK1 http://www.ncbi.nlm.nih.gov/gene/?term=55184 "ANKRD64, C20orf12, C20orf84, bA189K21.1, bA189K21.8, dJ568F9.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039853 55184 DZANK1 http://www.ncbi.nlm.nih.gov/gene/?term=55184 "ANKRD64, C20orf12, C20orf84, bA189K21.1, bA189K21.8, dJ568F9.2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039854 55187 VPS13D http://www.ncbi.nlm.nih.gov/gene/?term=55187 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039855 55187 VPS13D http://www.ncbi.nlm.nih.gov/gene/?term=55187 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039856 55188 RIC8B http://www.ncbi.nlm.nih.gov/gene/?term=55188 "RIC8, hSyn" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039857 55193 PBRM1 http://www.ncbi.nlm.nih.gov/gene/?term=55193 "BAF180, PB1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039858 55193 PBRM1 http://www.ncbi.nlm.nih.gov/gene/?term=55193 "BAF180, PB1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039859 55195 CCDC198 http://www.ncbi.nlm.nih.gov/gene/?term=55195 C14orf105 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039860 55198 APPL2 http://www.ncbi.nlm.nih.gov/gene/?term=55198 DIP13B mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039861 55198 APPL2 http://www.ncbi.nlm.nih.gov/gene/?term=55198 DIP13B mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039862 55200 PLEKHG6 http://www.ncbi.nlm.nih.gov/gene/?term=55200 MyoGEF mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039863 55200 PLEKHG6 http://www.ncbi.nlm.nih.gov/gene/?term=55200 MyoGEF mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039864 55206 SBNO1 http://www.ncbi.nlm.nih.gov/gene/?term=55206 "MOP3, Sno" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039865 55230 USP40 http://www.ncbi.nlm.nih.gov/gene/?term=55230 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039866 55230 USP40 http://www.ncbi.nlm.nih.gov/gene/?term=55230 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039867 55234 SMU1 http://www.ncbi.nlm.nih.gov/gene/?term=55234 "BWD, SMU-1, fSAP57" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039868 55234 SMU1 http://www.ncbi.nlm.nih.gov/gene/?term=55234 "BWD, SMU-1, fSAP57" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039869 5524 PTPA http://www.ncbi.nlm.nih.gov/gene/?term=5524 "PP2A, PPP2R4, PR53" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039870 5524 PTPA http://www.ncbi.nlm.nih.gov/gene/?term=5524 "PP2A, PPP2R4, PR53" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039871 55249 YY1AP1 http://www.ncbi.nlm.nih.gov/gene/?term=55249 "GRNG, HCCA1, HCCA2, YY1AP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039872 55252 ASXL2 http://www.ncbi.nlm.nih.gov/gene/?term=55252 "ASXH2, SHAPNS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039873 55255 WDR41 http://www.ncbi.nlm.nih.gov/gene/?term=55255 MSTP048 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039874 55256 ADI1 http://www.ncbi.nlm.nih.gov/gene/?term=55256 "APL1, ARD, Fe-ARD, HMFT1638, MTCBP1, Ni-ARD, SIPL, mtnD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039875 5527 PPP2R5C http://www.ncbi.nlm.nih.gov/gene/?term=5527 "B56G, B56gamma, PR61G" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039876 5527 PPP2R5C http://www.ncbi.nlm.nih.gov/gene/?term=5527 "B56G, B56gamma, PR61G" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039877 55275 VPS53 http://www.ncbi.nlm.nih.gov/gene/?term=55275 "HCCS1, PCH2E, hVps53L, pp13624" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039878 55275 VPS53 http://www.ncbi.nlm.nih.gov/gene/?term=55275 "HCCS1, PCH2E, hVps53L, pp13624" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039879 55284 UBE2W http://www.ncbi.nlm.nih.gov/gene/?term=55284 "UBC-16, UBC16" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039880 5529 PPP2R5E http://www.ncbi.nlm.nih.gov/gene/?term=5529 "B56E, B56epsilon" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039881 55291 PPP6R3 http://www.ncbi.nlm.nih.gov/gene/?term=55291 "C11orf23, PP6R3, SAP190, SAPL, SAPLa, SAPS3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039882 55291 PPP6R3 http://www.ncbi.nlm.nih.gov/gene/?term=55291 "C11orf23, PP6R3, SAP190, SAPL, SAPLa, SAPS3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039883 55294 FBXW7 http://www.ncbi.nlm.nih.gov/gene/?term=55294 "AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039884 55294 FBXW7 http://www.ncbi.nlm.nih.gov/gene/?term=55294 "AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039885 55298 RNF121 http://www.ncbi.nlm.nih.gov/gene/?term=55298 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039886 5530 PPP3CA http://www.ncbi.nlm.nih.gov/gene/?term=5530 "CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039887 5530 PPP3CA http://www.ncbi.nlm.nih.gov/gene/?term=5530 "CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039888 553115 PEF1 http://www.ncbi.nlm.nih.gov/gene/?term=553115 "ABP32A, PEF1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039889 553115 PEF1 http://www.ncbi.nlm.nih.gov/gene/?term=553115 "ABP32A, PEF1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039890 55339 WDR33 http://www.ncbi.nlm.nih.gov/gene/?term=55339 "NET14, WDC146" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039891 55342 STRBP http://www.ncbi.nlm.nih.gov/gene/?term=55342 "HEL162, ILF3L, SPNR, p74" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039892 55351 STK32B http://www.ncbi.nlm.nih.gov/gene/?term=55351 "HSA250839, STK32, STKG6, YANK2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039893 55351 STK32B http://www.ncbi.nlm.nih.gov/gene/?term=55351 "HSA250839, STK32, STKG6, YANK2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039894 55366 LGR4 http://www.ncbi.nlm.nih.gov/gene/?term=55366 "BNMD17, GPR48" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039895 55422 ZNF331 http://www.ncbi.nlm.nih.gov/gene/?term=55422 "RITA, ZNF361, ZNF463" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039896 55422 ZNF331 http://www.ncbi.nlm.nih.gov/gene/?term=55422 "RITA, ZNF361, ZNF463" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039897 55486 PARL http://www.ncbi.nlm.nih.gov/gene/?term=55486 "PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039898 55486 PARL http://www.ncbi.nlm.nih.gov/gene/?term=55486 "PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039899 55500 ETNK1 http://www.ncbi.nlm.nih.gov/gene/?term=55500 "EKI, EKI 1, EKI1, Nbla10396" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039900 55506 H2AFY2 http://www.ncbi.nlm.nih.gov/gene/?term=55506 macroH2A2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039901 55534 MAML3 http://www.ncbi.nlm.nih.gov/gene/?term=55534 "CAGH3, ERDA3, GDN, MAM-2, MAM2, TNRC3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039902 55534 MAML3 http://www.ncbi.nlm.nih.gov/gene/?term=55534 "CAGH3, ERDA3, GDN, MAM-2, MAM2, TNRC3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039903 55556 ENOSF1 http://www.ncbi.nlm.nih.gov/gene/?term=55556 "RTS, TYMSAS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039904 55556 ENOSF1 http://www.ncbi.nlm.nih.gov/gene/?term=55556 "RTS, TYMSAS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039905 55561 CDC42BPG http://www.ncbi.nlm.nih.gov/gene/?term=55561 "DMPK2, HSMDPKIN, KAPPA-200, MRCKG, MRCKgamma" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039906 55561 CDC42BPG http://www.ncbi.nlm.nih.gov/gene/?term=55561 "DMPK2, HSMDPKIN, KAPPA-200, MRCKG, MRCKgamma" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039907 55565 ZNF821 http://www.ncbi.nlm.nih.gov/gene/?term=55565 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039908 55568 GALNT10 http://www.ncbi.nlm.nih.gov/gene/?term=55568 "GALNACT10, PPGALNACT10, PPGANTASE10" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039909 55568 GALNT10 http://www.ncbi.nlm.nih.gov/gene/?term=55568 "GALNACT10, PPGALNACT10, PPGANTASE10" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039910 55589 BMP2K http://www.ncbi.nlm.nih.gov/gene/?term=55589 "BIKE, HRIHFB2017" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039911 55593 OTUD5 http://www.ncbi.nlm.nih.gov/gene/?term=55593 DUBA mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039912 55593 OTUD5 http://www.ncbi.nlm.nih.gov/gene/?term=55593 DUBA mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039913 55614 KIF16B http://www.ncbi.nlm.nih.gov/gene/?term=55614 "C20orf23, KISC20ORF, SNX23" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039914 55616 ASAP3 http://www.ncbi.nlm.nih.gov/gene/?term=55616 "ACAP4, CENTB6, DDEFL1, UPLC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039915 55616 ASAP3 http://www.ncbi.nlm.nih.gov/gene/?term=55616 "ACAP4, CENTB6, DDEFL1, UPLC1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039916 55619 DOCK10 http://www.ncbi.nlm.nih.gov/gene/?term=55619 "DRIP2, Nbla10300, ZIZ3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039917 55619 DOCK10 http://www.ncbi.nlm.nih.gov/gene/?term=55619 "DRIP2, Nbla10300, ZIZ3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039918 55626 AMBRA1 http://www.ncbi.nlm.nih.gov/gene/?term=55626 "DCAF3, WDR94" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039919 55626 AMBRA1 http://www.ncbi.nlm.nih.gov/gene/?term=55626 "DCAF3, WDR94" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039920 55628 ZNF407 http://www.ncbi.nlm.nih.gov/gene/?term=55628 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039921 55634 KRBOX4 http://www.ncbi.nlm.nih.gov/gene/?term=55634 ZNF673 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039922 55634 KRBOX4 http://www.ncbi.nlm.nih.gov/gene/?term=55634 ZNF673 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039923 55651 NHP2 http://www.ncbi.nlm.nih.gov/gene/?term=55651 "DKCB2P, NOLA2, NHP2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039924 55651 NHP2 http://www.ncbi.nlm.nih.gov/gene/?term=55651 "DKCB2P, NOLA2, NHP2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039925 55652 SLC48A1 http://www.ncbi.nlm.nih.gov/gene/?term=55652 "HRG-1, HRG1, hHRG-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039926 55666 NPLOC4 http://www.ncbi.nlm.nih.gov/gene/?term=55666 NPL4 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039927 55666 NPLOC4 http://www.ncbi.nlm.nih.gov/gene/?term=55666 NPL4 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039928 55667 DENND4C http://www.ncbi.nlm.nih.gov/gene/?term=55667 "C9orf55, C9orf55B, RAB10GEF, bA513M16.3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039929 55677 IWS1 http://www.ncbi.nlm.nih.gov/gene/?term=55677 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039930 55677 IWS1 http://www.ncbi.nlm.nih.gov/gene/?term=55677 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039931 55680 RUFY2 http://www.ncbi.nlm.nih.gov/gene/?term=55680 "RABIP4R, ZFYVE13" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039932 55680 RUFY2 http://www.ncbi.nlm.nih.gov/gene/?term=55680 "RABIP4R, ZFYVE13" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039933 55687 TRMU http://www.ncbi.nlm.nih.gov/gene/?term=55687 "LCAL3, MTO2, MTU1, TRMT, TRMT1, TRNT1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039934 55687 TRMU http://www.ncbi.nlm.nih.gov/gene/?term=55687 "LCAL3, MTO2, MTU1, TRMT, TRMT1, TRNT1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039935 55690 PACS1 http://www.ncbi.nlm.nih.gov/gene/?term=55690 "MRD17, SHMS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039936 55691 FRMD4A http://www.ncbi.nlm.nih.gov/gene/?term=55691 "CCAFCA, FRMD4, bA295P9.4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039937 55691 FRMD4A http://www.ncbi.nlm.nih.gov/gene/?term=55691 "CCAFCA, FRMD4, bA295P9.4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039938 55697 VAC14 http://www.ncbi.nlm.nih.gov/gene/?term=55697 "ArPIKfyve, TAX1BP2, TRX" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039939 55697 VAC14 http://www.ncbi.nlm.nih.gov/gene/?term=55697 "ArPIKfyve, TAX1BP2, TRX" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039940 55704 CCDC88A http://www.ncbi.nlm.nih.gov/gene/?term=55704 "APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212, PEHO, PEHOL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039941 55720 TSR1 http://www.ncbi.nlm.nih.gov/gene/?term=55720 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039942 55720 TSR1 http://www.ncbi.nlm.nih.gov/gene/?term=55720 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039943 55727 BTBD7 http://www.ncbi.nlm.nih.gov/gene/?term=55727 FUP1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039944 55731 FAM222B http://www.ncbi.nlm.nih.gov/gene/?term=55731 C17orf63 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039945 55740 ENAH http://www.ncbi.nlm.nih.gov/gene/?term=55740 "ENA, MENA, NDPP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039946 55740 ENAH http://www.ncbi.nlm.nih.gov/gene/?term=55740 "ENA, MENA, NDPP1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039947 55748 CNDP2 http://www.ncbi.nlm.nih.gov/gene/?term=55748 "CN2, CPGL, HEL-S-13, HsT2298, PEPA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039948 55748 CNDP2 http://www.ncbi.nlm.nih.gov/gene/?term=55748 "CN2, CPGL, HEL-S-13, HsT2298, PEPA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039949 55758 RCOR3 http://www.ncbi.nlm.nih.gov/gene/?term=55758 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039950 55760 DHX32 http://www.ncbi.nlm.nih.gov/gene/?term=55760 "DDX32, DHLP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039951 55760 DHX32 http://www.ncbi.nlm.nih.gov/gene/?term=55760 "DDX32, DHLP1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039952 55761 TTC17 http://www.ncbi.nlm.nih.gov/gene/?term=55761 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039953 55763 EXOC1 http://www.ncbi.nlm.nih.gov/gene/?term=55763 "BM-102, SEC3, SEC3L1, SEC3P" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039954 55764 IFT122 http://www.ncbi.nlm.nih.gov/gene/?term=55764 "CED, CED1, SPG, WDR10, WDR10p, WDR140" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039955 55764 IFT122 http://www.ncbi.nlm.nih.gov/gene/?term=55764 "CED, CED1, SPG, WDR10, WDR10p, WDR140" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039956 55768 NGLY1 http://www.ncbi.nlm.nih.gov/gene/?term=55768 "CDDG, CDG1V, PNG1, PNGase" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039957 55769 ZNF83 http://www.ncbi.nlm.nih.gov/gene/?term=55769 "HPF1, ZNF816B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039958 55770 EXOC2 http://www.ncbi.nlm.nih.gov/gene/?term=55770 "SEC5, SEC5L1, Sec5p" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039959 55773 TBC1D23 http://www.ncbi.nlm.nih.gov/gene/?term=55773 NS4ATP1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039960 5578 PRKCA http://www.ncbi.nlm.nih.gov/gene/?term=5578 "AAG6, PKC-alpha, PKCA, PRKACA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039961 5578 PRKCA http://www.ncbi.nlm.nih.gov/gene/?term=5578 "AAG6, PKC-alpha, PKCA, PRKACA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039962 55789 DEPDC1B http://www.ncbi.nlm.nih.gov/gene/?term=55789 "BRCC3, XTP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039963 55789 DEPDC1B http://www.ncbi.nlm.nih.gov/gene/?term=55789 "BRCC3, XTP1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039964 55790 CSGALNACT1 http://www.ncbi.nlm.nih.gov/gene/?term=55790 "CSGalNAcT-1, ChGn, ChGn-1, beta4GalNAcT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039965 55790 CSGALNACT1 http://www.ncbi.nlm.nih.gov/gene/?term=55790 "CSGalNAcT-1, ChGn, ChGn-1, beta4GalNAcT" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039966 55791 LRIF1 http://www.ncbi.nlm.nih.gov/gene/?term=55791 "C1orf103, RIF1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039967 55796 MBNL3 http://www.ncbi.nlm.nih.gov/gene/?term=55796 "CHCR, MBLX, MBLX39, MBXL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039968 55796 MBNL3 http://www.ncbi.nlm.nih.gov/gene/?term=55796 "CHCR, MBLX, MBLX39, MBXL" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039969 55799 CACNA2D3 http://www.ncbi.nlm.nih.gov/gene/?term=55799 HSA272268 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039970 55799 CACNA2D3 http://www.ncbi.nlm.nih.gov/gene/?term=55799 HSA272268 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039971 55800 SCN3B http://www.ncbi.nlm.nih.gov/gene/?term=55800 "ATFB16, BRGDA7, HSA243396, SCNB3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039972 55800 SCN3B http://www.ncbi.nlm.nih.gov/gene/?term=55800 "ATFB16, BRGDA7, HSA243396, SCNB3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039973 55806 HR http://www.ncbi.nlm.nih.gov/gene/?term=55806 "ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039974 55806 HR http://www.ncbi.nlm.nih.gov/gene/?term=55806 "ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039975 55812 SPATA7 http://www.ncbi.nlm.nih.gov/gene/?term=55812 "HEL-S-296, HSD-3.1, HSD3, LCA3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039976 55812 SPATA7 http://www.ncbi.nlm.nih.gov/gene/?term=55812 "HEL-S-296, HSD-3.1, HSD3, LCA3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039977 55824 PAG1 http://www.ncbi.nlm.nih.gov/gene/?term=55824 "CBP, PAG" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039978 55824 PAG1 http://www.ncbi.nlm.nih.gov/gene/?term=55824 "CBP, PAG" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039979 55827 DCAF6 http://www.ncbi.nlm.nih.gov/gene/?term=55827 "1200006M05Rik, ARCAP, IQWD1, MSTP055, NRIP, PC326" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039980 55827 DCAF6 http://www.ncbi.nlm.nih.gov/gene/?term=55827 "1200006M05Rik, ARCAP, IQWD1, MSTP055, NRIP, PC326" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039981 5583 PRKCH http://www.ncbi.nlm.nih.gov/gene/?term=5583 "PKC-L, PKCL, PRKCL, nPKC-eta" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039982 55841 WWC3 http://www.ncbi.nlm.nih.gov/gene/?term=55841 BM042 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039983 55841 WWC3 http://www.ncbi.nlm.nih.gov/gene/?term=55841 BM042 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039984 55857 KIZ http://www.ncbi.nlm.nih.gov/gene/?term=55857 "C20orf19, HT013, Kizuna, NCRNA00153, PLK1S1, RP69" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039985 55858 TMEM165 http://www.ncbi.nlm.nih.gov/gene/?term=55858 "CDG2K, FT27, GDT1, TMPT27, TPARL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039986 55858 TMEM165 http://www.ncbi.nlm.nih.gov/gene/?term=55858 "CDG2K, FT27, GDT1, TMPT27, TPARL" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039987 5586 PKN2 http://www.ncbi.nlm.nih.gov/gene/?term=5586 "PAK2, PRK2, PRKCL2, PRO2042, Pak-2, STK7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039988 5586 PKN2 http://www.ncbi.nlm.nih.gov/gene/?term=5586 "PAK2, PRK2, PRKCL2, PRO2042, Pak-2, STK7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039989 55862 ECHDC1 http://www.ncbi.nlm.nih.gov/gene/?term=55862 "HEL-S-76, MMCD, dJ351K20.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039990 55869 HDAC8 http://www.ncbi.nlm.nih.gov/gene/?term=55869 "CDA07, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039991 55869 HDAC8 http://www.ncbi.nlm.nih.gov/gene/?term=55869 "CDA07, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039992 55884 WSB2 http://www.ncbi.nlm.nih.gov/gene/?term=55884 SBA2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039993 55884 WSB2 http://www.ncbi.nlm.nih.gov/gene/?term=55884 SBA2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039994 55902 ACSS2 http://www.ncbi.nlm.nih.gov/gene/?term=55902 "ACAS2, ACECS, ACS, ACSA, dJ1161H23.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039995 55902 ACSS2 http://www.ncbi.nlm.nih.gov/gene/?term=55902 "ACAS2, ACECS, ACS, ACSA, dJ1161H23.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039996 55904 KMT2E http://www.ncbi.nlm.nih.gov/gene/?term=55904 "HDCMC04P, MLL5, NKp44L" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039997 55920 RCC2 http://www.ncbi.nlm.nih.gov/gene/?term=55920 TD-60 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00039998 55920 RCC2 http://www.ncbi.nlm.nih.gov/gene/?term=55920 TD-60 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00039999 55930 MYO5C http://www.ncbi.nlm.nih.gov/gene/?term=55930 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040000 55930 MYO5C http://www.ncbi.nlm.nih.gov/gene/?term=55930 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040001 55967 NDUFA12 http://www.ncbi.nlm.nih.gov/gene/?term=55967 "B17.2, DAP13" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040002 55967 NDUFA12 http://www.ncbi.nlm.nih.gov/gene/?term=55967 "B17.2, DAP13" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040003 5597 MAPK6 http://www.ncbi.nlm.nih.gov/gene/?term=5597 "ERK3, HsT17250, PRKM6, p97MAPK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040004 55970 GNG12 http://www.ncbi.nlm.nih.gov/gene/?term=55970 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040005 55970 GNG12 http://www.ncbi.nlm.nih.gov/gene/?term=55970 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040006 55973 BCAP29 http://www.ncbi.nlm.nih.gov/gene/?term=55973 BAP29 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040007 56034 PDGFC http://www.ncbi.nlm.nih.gov/gene/?term=56034 "FALLOTEIN, SCDGF" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040008 56034 PDGFC http://www.ncbi.nlm.nih.gov/gene/?term=56034 "FALLOTEIN, SCDGF" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040009 5607 MAP2K5 http://www.ncbi.nlm.nih.gov/gene/?term=5607 "HsT17454, MAPKK5, MEK5, PRKMK5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040010 5607 MAP2K5 http://www.ncbi.nlm.nih.gov/gene/?term=5607 "HsT17454, MAPKK5, MEK5, PRKMK5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040011 5611 DNAJC3 http://www.ncbi.nlm.nih.gov/gene/?term=5611 "ACPHD, ERdj6, HP58, P58, P58IPK, PRKRI" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040012 5613 PRKX http://www.ncbi.nlm.nih.gov/gene/?term=5613 PKX1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040013 56172 ANKH http://www.ncbi.nlm.nih.gov/gene/?term=56172 "ANK, CCAL2, CMDJ, CPPDD, HANK, MANK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040014 56204 FAM214A http://www.ncbi.nlm.nih.gov/gene/?term=56204 KIAA1370 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040015 56204 FAM214A http://www.ncbi.nlm.nih.gov/gene/?term=56204 KIAA1370 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040016 56243 KIAA1217 http://www.ncbi.nlm.nih.gov/gene/?term=56243 "ETL4, SKT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040017 56243 KIAA1217 http://www.ncbi.nlm.nih.gov/gene/?term=56243 "ETL4, SKT" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040018 56261 GPCPD1 http://www.ncbi.nlm.nih.gov/gene/?term=56261 "EDI3, GDE5, GDPD6, PREI4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040019 56270 WDR45B http://www.ncbi.nlm.nih.gov/gene/?term=56270 "WDR45L, WIPI-3, WIPI3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040020 56270 WDR45B http://www.ncbi.nlm.nih.gov/gene/?term=56270 "WDR45L, WIPI-3, WIPI3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040021 56288 PARD3 http://www.ncbi.nlm.nih.gov/gene/?term=56288 "ASIP, Baz, PAR3, PAR3alpha, PARD-3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, PARD3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040022 56288 PARD3 http://www.ncbi.nlm.nih.gov/gene/?term=56288 "ASIP, Baz, PAR3, PAR3alpha, PARD-3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, PARD3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040023 56474 CTPS2 http://www.ncbi.nlm.nih.gov/gene/?term=56474 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040024 56474 CTPS2 http://www.ncbi.nlm.nih.gov/gene/?term=56474 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040025 56478 EIF4ENIF1 http://www.ncbi.nlm.nih.gov/gene/?term=56478 "4E-T, Clast4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040026 56478 EIF4ENIF1 http://www.ncbi.nlm.nih.gov/gene/?term=56478 "4E-T, Clast4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040027 5649 RELN http://www.ncbi.nlm.nih.gov/gene/?term=5649 "ETL7, LIS2, PRO1598, RL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040028 5649 RELN http://www.ncbi.nlm.nih.gov/gene/?term=5649 "ETL7, LIS2, PRO1598, RL" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040029 56623 INPP5E http://www.ncbi.nlm.nih.gov/gene/?term=56623 "CORS1, CPD4, JBTS1, MORMS, PPI5PIV, pharbin" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040030 56623 INPP5E http://www.ncbi.nlm.nih.gov/gene/?term=56623 "CORS1, CPD4, JBTS1, MORMS, PPI5PIV, pharbin" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040031 56660 KCNK12 http://www.ncbi.nlm.nih.gov/gene/?term=56660 "K2p12.1, THIK-2, THIK2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040032 5682 PSMA1 http://www.ncbi.nlm.nih.gov/gene/?term=5682 "NU, HC2, PROS30, HEL-S-275" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040033 5682 PSMA1 http://www.ncbi.nlm.nih.gov/gene/?term=5682 "NU, HC2, PROS30, HEL-S-275" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040034 56850 GRIPAP1 http://www.ncbi.nlm.nih.gov/gene/?term=56850 GRASP-1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040035 56850 GRIPAP1 http://www.ncbi.nlm.nih.gov/gene/?term=56850 GRASP-1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040036 56886 UGGT1 http://www.ncbi.nlm.nih.gov/gene/?term=56886 "HUGT1, UGCGL1, UGT1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040037 56886 UGGT1 http://www.ncbi.nlm.nih.gov/gene/?term=56886 "HUGT1, UGCGL1, UGT1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040038 56889 TM9SF3 http://www.ncbi.nlm.nih.gov/gene/?term=56889 "EP70-P-iso, SMBP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040039 56889 TM9SF3 http://www.ncbi.nlm.nih.gov/gene/?term=56889 "EP70-P-iso, SMBP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040040 56894 AGPAT3 http://www.ncbi.nlm.nih.gov/gene/?term=56894 "LPAAT-GAMMA1, LPAAT3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040041 56894 AGPAT3 http://www.ncbi.nlm.nih.gov/gene/?term=56894 "LPAAT-GAMMA1, LPAAT3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040042 56899 ANKS1B http://www.ncbi.nlm.nih.gov/gene/?term=56899 "AIDA, AIDA-1, ANKS2, EB-1, EB1, cajalin-2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040043 56947 MFF http://www.ncbi.nlm.nih.gov/gene/?term=56947 "C2orf33, EMPF2, GL004" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040044 56947 MFF http://www.ncbi.nlm.nih.gov/gene/?term=56947 "C2orf33, EMPF2, GL004" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040045 5695 PSMB7 http://www.ncbi.nlm.nih.gov/gene/?term=5695 Z mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040046 5695 PSMB7 http://www.ncbi.nlm.nih.gov/gene/?term=5695 Z mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040047 56957 OTUD7B http://www.ncbi.nlm.nih.gov/gene/?term=56957 "ZA20D1, CEZANNE" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040048 56987 BBX http://www.ncbi.nlm.nih.gov/gene/?term=56987 "ARTC1, HBP2, HSPC339, MDS001" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040049 56987 BBX http://www.ncbi.nlm.nih.gov/gene/?term=56987 "ARTC1, HBP2, HSPC339, MDS001" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040050 56992 KIF15 http://www.ncbi.nlm.nih.gov/gene/?term=56992 "HKLP2, KLP2, KNSL7, NY-BR-62" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040051 56995 TULP4 http://www.ncbi.nlm.nih.gov/gene/?term=56995 TUSP mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040052 56995 TULP4 http://www.ncbi.nlm.nih.gov/gene/?term=56995 TUSP mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040053 56997 COQ8A http://www.ncbi.nlm.nih.gov/gene/?term=56997 "ADCK3, ARCA2, CABC1, COQ10D4, COQ8, SCAR9" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040054 56997 COQ8A http://www.ncbi.nlm.nih.gov/gene/?term=56997 "ADCK3, ARCA2, CABC1, COQ10D4, COQ8, SCAR9" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040055 57007 ACKR3 http://www.ncbi.nlm.nih.gov/gene/?term=57007 "CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040056 57020 C16orf62 http://www.ncbi.nlm.nih.gov/gene/?term=57020 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040057 57020 C16orf62 http://www.ncbi.nlm.nih.gov/gene/?term=57020 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040058 57060 PCBP4 http://www.ncbi.nlm.nih.gov/gene/?term=57060 "CBP, LIP4, MCG10" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040059 57060 PCBP4 http://www.ncbi.nlm.nih.gov/gene/?term=57060 "CBP, LIP4, MCG10" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040060 5707 PSMD1 http://www.ncbi.nlm.nih.gov/gene/?term=5707 "P112, Rpn2, S1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040061 57111 RAB25 http://www.ncbi.nlm.nih.gov/gene/?term=57111 "CATX-8, RAB11C" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040062 57111 RAB25 http://www.ncbi.nlm.nih.gov/gene/?term=57111 "CATX-8, RAB11C" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040063 57142 RTN4 http://www.ncbi.nlm.nih.gov/gene/?term=57142 "ASY, NI220/250, NOGO, NSP, NSP-CL, Nbla00271, Nbla10545, RTN-X-A, RTN4-B1, RTN4-B2, RTN4-C, RTN4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040064 57146 TMEM159 http://www.ncbi.nlm.nih.gov/gene/?term=57146 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040065 57147 SCYL3 http://www.ncbi.nlm.nih.gov/gene/?term=57147 "PACE-1, PACE1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040066 57147 SCYL3 http://www.ncbi.nlm.nih.gov/gene/?term=57147 "PACE-1, PACE1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040067 57154 SMURF1 http://www.ncbi.nlm.nih.gov/gene/?term=57154 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040068 57154 SMURF1 http://www.ncbi.nlm.nih.gov/gene/?term=57154 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040069 57169 ZNFX1 http://www.ncbi.nlm.nih.gov/gene/?term=57169 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040070 57169 ZNFX1 http://www.ncbi.nlm.nih.gov/gene/?term=57169 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040071 57178 ZMIZ1 http://www.ncbi.nlm.nih.gov/gene/?term=57178 "MIZ, RAI17, TRAFIP10, ZIMP10" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040072 57178 ZMIZ1 http://www.ncbi.nlm.nih.gov/gene/?term=57178 "MIZ, RAI17, TRAFIP10, ZIMP10" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040073 57181 SLC39A10 http://www.ncbi.nlm.nih.gov/gene/?term=57181 LZT-Hs2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040074 57181 SLC39A10 http://www.ncbi.nlm.nih.gov/gene/?term=57181 LZT-Hs2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040075 57217 TTC7A http://www.ncbi.nlm.nih.gov/gene/?term=57217 "GIDID, MINAT, TTC7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040076 57217 TTC7A http://www.ncbi.nlm.nih.gov/gene/?term=57217 "GIDID, MINAT, TTC7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040077 57223 PPP4R3B http://www.ncbi.nlm.nih.gov/gene/?term=57223 "PSY2, smk1, FLFL2, SMEK2, PP4R3B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040078 5728 PTEN http://www.ncbi.nlm.nih.gov/gene/?term=5728 "10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC11, PTENbeta, TEP1, PTEN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040079 57325 KAT14 http://www.ncbi.nlm.nih.gov/gene/?term=57325 "ATAC2, CRP2BP, CSRP2BP, PRO1194, dJ717M23.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040080 57325 KAT14 http://www.ncbi.nlm.nih.gov/gene/?term=57325 "ATAC2, CRP2BP, CSRP2BP, PRO1194, dJ717M23.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040081 57405 SPC25 http://www.ncbi.nlm.nih.gov/gene/?term=57405 "AD024, SPBC25, hSpc25" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040082 57408 LRTM1 http://www.ncbi.nlm.nih.gov/gene/?term=57408 HT017 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040083 57408 LRTM1 http://www.ncbi.nlm.nih.gov/gene/?term=57408 HT017 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040084 57414 RHBDD2 http://www.ncbi.nlm.nih.gov/gene/?term=57414 "NPD007, RHBDL7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040085 57414 RHBDD2 http://www.ncbi.nlm.nih.gov/gene/?term=57414 "NPD007, RHBDL7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040086 57448 BIRC6 http://www.ncbi.nlm.nih.gov/gene/?term=57448 "APOLLON, BRUCE" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040087 57448 BIRC6 http://www.ncbi.nlm.nih.gov/gene/?term=57448 "APOLLON, BRUCE" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040088 57458 TMCC3 http://www.ncbi.nlm.nih.gov/gene/?term=57458 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040089 57458 TMCC3 http://www.ncbi.nlm.nih.gov/gene/?term=57458 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040090 57459 GATAD2B http://www.ncbi.nlm.nih.gov/gene/?term=57459 "MRD18, P66beta, p68" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040091 57459 GATAD2B http://www.ncbi.nlm.nih.gov/gene/?term=57459 "MRD18, P66beta, p68" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040092 5747 PTK2 http://www.ncbi.nlm.nih.gov/gene/?term=5747 "FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040093 5747 PTK2 http://www.ncbi.nlm.nih.gov/gene/?term=5747 "FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040094 57473 ZNF512B http://www.ncbi.nlm.nih.gov/gene/?term=57473 GM632 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040095 57473 ZNF512B http://www.ncbi.nlm.nih.gov/gene/?term=57473 GM632 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040096 57478 USP31 http://www.ncbi.nlm.nih.gov/gene/?term=57478 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040097 57488 ESYT2 http://www.ncbi.nlm.nih.gov/gene/?term=57488 "CHR2SYT, E-Syt2, FAM62B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040098 57488 ESYT2 http://www.ncbi.nlm.nih.gov/gene/?term=57488 "CHR2SYT, E-Syt2, FAM62B" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040099 57492 ARID1B http://www.ncbi.nlm.nih.gov/gene/?term=57492 "6A3-5, BAF250B, BRIGHT, CSS1, DAN15, ELD/OSA1, MRD12, OSA2, P250R" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040100 57492 ARID1B http://www.ncbi.nlm.nih.gov/gene/?term=57492 "6A3-5, BAF250B, BRIGHT, CSS1, DAN15, ELD/OSA1, MRD12, OSA2, P250R" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040101 57498 KIDINS220 http://www.ncbi.nlm.nih.gov/gene/?term=57498 "ARMS, SINO" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040102 57507 ZNF608 http://www.ncbi.nlm.nih.gov/gene/?term=57507 NY-REN-36 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040103 57507 ZNF608 http://www.ncbi.nlm.nih.gov/gene/?term=57507 NY-REN-36 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040104 57510 XPO5 http://www.ncbi.nlm.nih.gov/gene/?term=57510 exp5 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040105 57510 XPO5 http://www.ncbi.nlm.nih.gov/gene/?term=57510 exp5 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040106 57521 RPTOR http://www.ncbi.nlm.nih.gov/gene/?term=57521 "KOG1, Mip1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040107 57521 RPTOR http://www.ncbi.nlm.nih.gov/gene/?term=57521 "KOG1, Mip1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040108 57522 SRGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=57522 "ARHGAP13, NMTC2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040109 57522 SRGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=57522 "ARHGAP13, NMTC2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040110 57552 NCEH1 http://www.ncbi.nlm.nih.gov/gene/?term=57552 "AADACL1, NCEH" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040111 57552 NCEH1 http://www.ncbi.nlm.nih.gov/gene/?term=57552 "AADACL1, NCEH" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040112 57559 STAMBPL1 http://www.ncbi.nlm.nih.gov/gene/?term=57559 "ALMalpha, AMSH-FP, AMSH-LP, bA399O19.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040113 57559 STAMBPL1 http://www.ncbi.nlm.nih.gov/gene/?term=57559 "ALMalpha, AMSH-FP, AMSH-LP, bA399O19.2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040114 57563 KLHL8 http://www.ncbi.nlm.nih.gov/gene/?term=57563 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040115 57563 KLHL8 http://www.ncbi.nlm.nih.gov/gene/?term=57563 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040116 57568 SIPA1L2 http://www.ncbi.nlm.nih.gov/gene/?term=57568 SPAL2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040117 57590 WDFY1 http://www.ncbi.nlm.nih.gov/gene/?term=57590 "FENS-1, WDF1, ZFYVE17" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040118 57590 WDFY1 http://www.ncbi.nlm.nih.gov/gene/?term=57590 "FENS-1, WDF1, ZFYVE17" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040119 57591 MKL1 http://www.ncbi.nlm.nih.gov/gene/?term=57591 "BSAC, MAL, MKL, MRTF-A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040120 57591 MKL1 http://www.ncbi.nlm.nih.gov/gene/?term=57591 "BSAC, MAL, MKL, MRTF-A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040121 57609 DIP2B http://www.ncbi.nlm.nih.gov/gene/?term=57609 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040122 57609 DIP2B http://www.ncbi.nlm.nih.gov/gene/?term=57609 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040123 57620 STIM2 http://www.ncbi.nlm.nih.gov/gene/?term=57620 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040124 57628 DPP10 http://www.ncbi.nlm.nih.gov/gene/?term=57628 "DPL2, DPPY, DPRP-3, DPRP3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040125 57628 DPP10 http://www.ncbi.nlm.nih.gov/gene/?term=57628 "DPL2, DPPY, DPRP-3, DPRP3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040126 57630 SH3RF1 http://www.ncbi.nlm.nih.gov/gene/?term=57630 "POSH, RNF142, SH3MD2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040127 57645 POGK http://www.ncbi.nlm.nih.gov/gene/?term=57645 "BASS2, KRBOX2, LST003" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040128 57654 UVSSA http://www.ncbi.nlm.nih.gov/gene/?term=57654 "KIAA1530, UVSS3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040129 57654 UVSSA http://www.ncbi.nlm.nih.gov/gene/?term=57654 "KIAA1530, UVSS3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040130 57669 EPB41L5 http://www.ncbi.nlm.nih.gov/gene/?term=57669 "BE37, YMO1, YRT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040131 57677 ZFP14 http://www.ncbi.nlm.nih.gov/gene/?term=57677 ZNF531 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040132 5768 QSOX1 http://www.ncbi.nlm.nih.gov/gene/?term=5768 "Q6, QSCN6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040133 57693 ZNF317 http://www.ncbi.nlm.nih.gov/gene/?term=57693 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040134 57698 SHTN1 http://www.ncbi.nlm.nih.gov/gene/?term=57698 "KIAA1598, shootin-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040135 57698 SHTN1 http://www.ncbi.nlm.nih.gov/gene/?term=57698 "KIAA1598, shootin-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040136 57706 DENND1A http://www.ncbi.nlm.nih.gov/gene/?term=57706 "FAM31A, KIAA1608" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040137 57706 DENND1A http://www.ncbi.nlm.nih.gov/gene/?term=57706 "FAM31A, KIAA1608" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040138 57721 METTL14 http://www.ncbi.nlm.nih.gov/gene/?term=57721 hMETTL14 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040139 57724 EPG5 http://www.ncbi.nlm.nih.gov/gene/?term=57724 "HEEW1, KIAA1632, VICIS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040140 57724 EPG5 http://www.ncbi.nlm.nih.gov/gene/?term=57724 "HEEW1, KIAA1632, VICIS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040141 5775 PTPN4 http://www.ncbi.nlm.nih.gov/gene/?term=5775 "MEG, PTPMEG, PTPMEG1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040142 5775 PTPN4 http://www.ncbi.nlm.nih.gov/gene/?term=5775 "MEG, PTPMEG, PTPMEG1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040143 57787 MARK4 http://www.ncbi.nlm.nih.gov/gene/?term=57787 "MARK4LS, MARKL1, MARKL1L, PAR-1D, MARK4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040144 57787 MARK4 http://www.ncbi.nlm.nih.gov/gene/?term=57787 "MARK4LS, MARKL1, MARKL1L, PAR-1D, MARK4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040145 57795 BRINP2 http://www.ncbi.nlm.nih.gov/gene/?term=57795 "DBCCR1L2, FAM5B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040146 57795 BRINP2 http://www.ncbi.nlm.nih.gov/gene/?term=57795 "DBCCR1L2, FAM5B" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040147 57799 RAB40C http://www.ncbi.nlm.nih.gov/gene/?term=57799 "RARL, RASL8C" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040148 5782 PTPN12 http://www.ncbi.nlm.nih.gov/gene/?term=5782 "PTP-PEST, PTPG1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040149 57822 GRHL3 http://www.ncbi.nlm.nih.gov/gene/?term=57822 "SOM, TFCP2L4, VWS2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040150 57822 GRHL3 http://www.ncbi.nlm.nih.gov/gene/?term=57822 "SOM, TFCP2L4, VWS2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040151 5783 PTPN13 http://www.ncbi.nlm.nih.gov/gene/?term=5783 "FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040152 5784 PTPN14 http://www.ncbi.nlm.nih.gov/gene/?term=5784 "PEZ, PTP36" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040153 5789 PTPRD http://www.ncbi.nlm.nih.gov/gene/?term=5789 "HPTP, HPTPD, HPTPDELTA, PTPD, RPTPDELTA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040154 5789 PTPRD http://www.ncbi.nlm.nih.gov/gene/?term=5789 "HPTP, HPTPD, HPTPDELTA, PTPD, RPTPDELTA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040155 5791 PTPRE http://www.ncbi.nlm.nih.gov/gene/?term=5791 "HPTPE, PTPE, R-PTP-EPSILON" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040156 5791 PTPRE http://www.ncbi.nlm.nih.gov/gene/?term=5791 "HPTPE, PTPE, R-PTP-EPSILON" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040157 5793 PTPRG http://www.ncbi.nlm.nih.gov/gene/?term=5793 "HPTPG, PTPG, R-PTP-GAMMA, RPTPG" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040158 5793 PTPRG http://www.ncbi.nlm.nih.gov/gene/?term=5793 "HPTPG, PTPG, R-PTP-GAMMA, RPTPG" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040159 5795 PTPRJ http://www.ncbi.nlm.nih.gov/gene/?term=5795 "CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040160 5795 PTPRJ http://www.ncbi.nlm.nih.gov/gene/?term=5795 "CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040161 5796 PTPRK http://www.ncbi.nlm.nih.gov/gene/?term=5796 R-PTP-kappa mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040162 5797 PTPRM http://www.ncbi.nlm.nih.gov/gene/?term=5797 "PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040163 5797 PTPRM http://www.ncbi.nlm.nih.gov/gene/?term=5797 "PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040164 5799 PTPRN2 http://www.ncbi.nlm.nih.gov/gene/?term=5799 "IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040165 5799 PTPRN2 http://www.ncbi.nlm.nih.gov/gene/?term=5799 "IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040166 58155 PTBP2 http://www.ncbi.nlm.nih.gov/gene/?term=58155 "PTBLP, brPTB, nPTB" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040167 58155 PTBP2 http://www.ncbi.nlm.nih.gov/gene/?term=58155 "PTBLP, brPTB, nPTB" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040168 5819 NECTIN2 http://www.ncbi.nlm.nih.gov/gene/?term=5819 "CD112, HVEB, PRR2, PVRL2, PVRR2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040169 5819 NECTIN2 http://www.ncbi.nlm.nih.gov/gene/?term=5819 "CD112, HVEB, PRR2, PVRL2, PVRR2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040170 5829 PXN http://www.ncbi.nlm.nih.gov/gene/?term=5829 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040171 5829 PXN http://www.ncbi.nlm.nih.gov/gene/?term=5829 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040172 58506 SCAF1 http://www.ncbi.nlm.nih.gov/gene/?term=58506 SRA1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040173 58506 SCAF1 http://www.ncbi.nlm.nih.gov/gene/?term=58506 SRA1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040174 58508 KMT2C http://www.ncbi.nlm.nih.gov/gene/?term=58508 "HALR, MLL3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040175 58508 KMT2C http://www.ncbi.nlm.nih.gov/gene/?term=58508 "HALR, MLL3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040176 58513 EPS15L1 http://www.ncbi.nlm.nih.gov/gene/?term=58513 EPS15R mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040177 58513 EPS15L1 http://www.ncbi.nlm.nih.gov/gene/?term=58513 EPS15R mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040178 5862 RAB2A http://www.ncbi.nlm.nih.gov/gene/?term=5862 "LHX, RAB2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040179 5868 RAB5A http://www.ncbi.nlm.nih.gov/gene/?term=5868 RAB5 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040180 5869 RAB5B http://www.ncbi.nlm.nih.gov/gene/?term=5869 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040181 5870 RAB6A http://www.ncbi.nlm.nih.gov/gene/?term=5870 RAB6 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040182 5870 RAB6A http://www.ncbi.nlm.nih.gov/gene/?term=5870 RAB6 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040183 5887 RAD23B http://www.ncbi.nlm.nih.gov/gene/?term=5887 "HHR23B, HR23B, P58" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040184 5890 RAD51B http://www.ncbi.nlm.nih.gov/gene/?term=5890 "R51H2, RAD51L1, REC2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040185 5890 RAD51B http://www.ncbi.nlm.nih.gov/gene/?term=5890 "R51H2, RAD51L1, REC2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040186 5906 RAP1A http://www.ncbi.nlm.nih.gov/gene/?term=5906 "C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040187 5910 RAP1GDS1 http://www.ncbi.nlm.nih.gov/gene/?term=5910 "GDS1, SmgGDS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040188 5918 RARRES1 http://www.ncbi.nlm.nih.gov/gene/?term=5918 "LXNL, PERG-1, TIG1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040189 5921 RASA1 http://www.ncbi.nlm.nih.gov/gene/?term=5921 "CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120, p120GAP, p120RASGAP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040190 5921 RASA1 http://www.ncbi.nlm.nih.gov/gene/?term=5921 "CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120, p120GAP, p120RASGAP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040191 5924 RASGRF2 http://www.ncbi.nlm.nih.gov/gene/?term=5924 "GRF2, RAS-GRF2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040192 5924 RASGRF2 http://www.ncbi.nlm.nih.gov/gene/?term=5924 "GRF2, RAS-GRF2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040193 5925 RB1 http://www.ncbi.nlm.nih.gov/gene/?term=5925 "OSRC, PPP1R130, RB, p105-Rb, pRb, pp110" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040194 5925 RB1 http://www.ncbi.nlm.nih.gov/gene/?term=5925 "OSRC, PPP1R130, RB, p105-Rb, pRb, pp110" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040195 59271 EVA1C http://www.ncbi.nlm.nih.gov/gene/?term=59271 "B18, B19, C21orf63, C21orf64, FAM176C, PRED34, SUE21" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040196 59271 EVA1C http://www.ncbi.nlm.nih.gov/gene/?term=59271 "B18, B19, C21orf63, C21orf64, FAM176C, PRED34, SUE21" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040197 59277 NTN4 http://www.ncbi.nlm.nih.gov/gene/?term=59277 PRO3091 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040198 59277 NTN4 http://www.ncbi.nlm.nih.gov/gene/?term=59277 PRO3091 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040199 59345 GNB4 http://www.ncbi.nlm.nih.gov/gene/?term=59345 CMTD1F mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040200 5937 RBMS1 http://www.ncbi.nlm.nih.gov/gene/?term=5937 "C2orf12, HCC-4, MSSP, MSSP-1, MSSP-2, MSSP-3, SCR2, YC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040201 596 BCL2 http://www.ncbi.nlm.nih.gov/gene/?term=596 "Bcl-2, PPP1R50" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040202 596 BCL2 http://www.ncbi.nlm.nih.gov/gene/?term=596 "Bcl-2, PPP1R50" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040203 5980 REV3L http://www.ncbi.nlm.nih.gov/gene/?term=5980 "POLZ, REV3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040204 5980 REV3L http://www.ncbi.nlm.nih.gov/gene/?term=5980 "POLZ, REV3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040205 5991 RFX3 http://www.ncbi.nlm.nih.gov/gene/?term=5991 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040206 5991 RFX3 http://www.ncbi.nlm.nih.gov/gene/?term=5991 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040207 5994 RFXAP http://www.ncbi.nlm.nih.gov/gene/?term=5994 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040208 5998 RGS3 http://www.ncbi.nlm.nih.gov/gene/?term=5998 "C2PA, RGP3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040209 5998 RGS3 http://www.ncbi.nlm.nih.gov/gene/?term=5998 "C2PA, RGP3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040210 6009 RHEB http://www.ncbi.nlm.nih.gov/gene/?term=6009 RHEB2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040211 6009 RHEB http://www.ncbi.nlm.nih.gov/gene/?term=6009 RHEB2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040212 604 BCL6 http://www.ncbi.nlm.nih.gov/gene/?term=604 "BCL5A, LAZ3, ZBTB27, ZNF51, BCL6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040213 604 BCL6 http://www.ncbi.nlm.nih.gov/gene/?term=604 "BCL5A, LAZ3, ZBTB27, ZNF51, BCL6" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040214 60412 EXOC4 http://www.ncbi.nlm.nih.gov/gene/?term=60412 "SEC8, SEC8L1, Sec8p" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040215 60412 EXOC4 http://www.ncbi.nlm.nih.gov/gene/?term=60412 "SEC8, SEC8L1, Sec8p" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040216 60468 BACH2 http://www.ncbi.nlm.nih.gov/gene/?term=60468 BTBD25 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040217 60468 BACH2 http://www.ncbi.nlm.nih.gov/gene/?term=60468 BTBD25 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040218 60490 PPCDC http://www.ncbi.nlm.nih.gov/gene/?term=60490 "MDS018, PPC-DC, coaC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040219 60490 PPCDC http://www.ncbi.nlm.nih.gov/gene/?term=60490 "MDS018, PPC-DC, coaC" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040220 605 BCL7A http://www.ncbi.nlm.nih.gov/gene/?term=605 BCL7 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040221 605 BCL7A http://www.ncbi.nlm.nih.gov/gene/?term=605 BCL7 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040222 6051 RNPEP http://www.ncbi.nlm.nih.gov/gene/?term=6051 "AP-B, APB" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040223 6051 RNPEP http://www.ncbi.nlm.nih.gov/gene/?term=6051 "AP-B, APB" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040224 60526 LDAH http://www.ncbi.nlm.nih.gov/gene/?term=60526 "C2orf43, hLDAH" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040225 60526 LDAH http://www.ncbi.nlm.nih.gov/gene/?term=60526 "C2orf43, hLDAH" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040226 60561 RINT1 http://www.ncbi.nlm.nih.gov/gene/?term=60561 RINT-1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040227 60598 KCNK15 http://www.ncbi.nlm.nih.gov/gene/?term=60598 "K2p15.1, KCNK11, KCNK14, KT3.3, TASK-5, TASK5, dJ781B1.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040228 60598 KCNK15 http://www.ncbi.nlm.nih.gov/gene/?term=60598 "K2p15.1, KCNK11, KCNK14, KT3.3, TASK-5, TASK5, dJ781B1.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040229 60684 TRAPPC11 http://www.ncbi.nlm.nih.gov/gene/?term=60684 "C4orf41, FOIGR, GRY, LGMD2S" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040230 60685 ZFAND3 http://www.ncbi.nlm.nih.gov/gene/?term=60685 TEX27 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040231 60685 ZFAND3 http://www.ncbi.nlm.nih.gov/gene/?term=60685 TEX27 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040232 607 BCL9 http://www.ncbi.nlm.nih.gov/gene/?term=607 LGS mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040233 607 BCL9 http://www.ncbi.nlm.nih.gov/gene/?term=607 LGS mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040234 6091 ROBO1 http://www.ncbi.nlm.nih.gov/gene/?term=6091 "DUTT1, SAX3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040235 6093 ROCK1 http://www.ncbi.nlm.nih.gov/gene/?term=6093 "P160ROCK, ROCK-I" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040236 6095 RORA http://www.ncbi.nlm.nih.gov/gene/?term=6095 "NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040237 6095 RORA http://www.ncbi.nlm.nih.gov/gene/?term=6095 "NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040238 613 BCR http://www.ncbi.nlm.nih.gov/gene/?term=613 "ALL1, CML, D22S11, D22S662, PHL, BCR" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040239 613 BCR http://www.ncbi.nlm.nih.gov/gene/?term=613 "ALL1, CML, D22S11, D22S662, PHL, BCR" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040240 6160 RPL31 http://www.ncbi.nlm.nih.gov/gene/?term=6160 L31 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040241 6164 RPL34 http://www.ncbi.nlm.nih.gov/gene/?term=6164 L34 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040242 6188 RPS3 http://www.ncbi.nlm.nih.gov/gene/?term=6188 S3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040243 6188 RPS3 http://www.ncbi.nlm.nih.gov/gene/?term=6188 S3 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040244 6196 RPS6KA2 http://www.ncbi.nlm.nih.gov/gene/?term=6196 "HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, p90RSK2, pp90RSK3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040245 6196 RPS6KA2 http://www.ncbi.nlm.nih.gov/gene/?term=6196 "HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, p90RSK2, pp90RSK3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040246 6197 RPS6KA3 http://www.ncbi.nlm.nih.gov/gene/?term=6197 "CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040247 6203 RPS9 http://www.ncbi.nlm.nih.gov/gene/?term=6203 S9 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040248 6203 RPS9 http://www.ncbi.nlm.nih.gov/gene/?term=6203 S9 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040249 6232 RPS27 http://www.ncbi.nlm.nih.gov/gene/?term=6232 "DBA17, MPS-1, MPS1, S27" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040250 6232 RPS27 http://www.ncbi.nlm.nih.gov/gene/?term=6232 "DBA17, MPS-1, MPS1, S27" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040251 6234 RPS28 http://www.ncbi.nlm.nih.gov/gene/?term=6234 "DBA15, S28" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040252 6234 RPS28 http://www.ncbi.nlm.nih.gov/gene/?term=6234 "DBA15, S28" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040253 6259 RYK http://www.ncbi.nlm.nih.gov/gene/?term=6259 "D3S3195, JTK5, JTK5A1, RYK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040254 6310 ATXN1 http://www.ncbi.nlm.nih.gov/gene/?term=6310 "ATX1, D6S504E, SCA1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040255 6310 ATXN1 http://www.ncbi.nlm.nih.gov/gene/?term=6310 "ATX1, D6S504E, SCA1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040256 6311 ATXN2 http://www.ncbi.nlm.nih.gov/gene/?term=6311 "ATX2, SCA2, TNRC13" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040257 6323 SCN1A http://www.ncbi.nlm.nih.gov/gene/?term=6323 "EIEE6, FEB3, FEB3A, FHM3, GEFSP2, HBSCI, NAC1, Nav1.1, SCN1, SMEI" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040258 636 BICD1 http://www.ncbi.nlm.nih.gov/gene/?term=636 BICD mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040259 636 BICD1 http://www.ncbi.nlm.nih.gov/gene/?term=636 BICD mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040260 63877 FAM204A http://www.ncbi.nlm.nih.gov/gene/?term=63877 "C10orf84, bA319I23.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040261 63877 FAM204A http://www.ncbi.nlm.nih.gov/gene/?term=63877 "C10orf84, bA319I23.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040262 63893 UBE2O http://www.ncbi.nlm.nih.gov/gene/?term=63893 E2-230K mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040263 63893 UBE2O http://www.ncbi.nlm.nih.gov/gene/?term=63893 E2-230K mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040264 63898 SH2D4A http://www.ncbi.nlm.nih.gov/gene/?term=63898 "PPP1R38, SH2A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040265 6390 SDHB http://www.ncbi.nlm.nih.gov/gene/?term=6390 "CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040266 63901 FAM111A http://www.ncbi.nlm.nih.gov/gene/?term=63901 "GCLEB, KCS2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040267 6392 SDHD http://www.ncbi.nlm.nih.gov/gene/?term=6392 "PGL, CBT1, CWS3, PGL1, QPs3, SDH4, cybS, CII-4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040268 6392 SDHD http://www.ncbi.nlm.nih.gov/gene/?term=6392 "PGL, CBT1, CWS3, PGL1, QPs3, SDH4, cybS, CII-4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040269 6397 SEC14L1 http://www.ncbi.nlm.nih.gov/gene/?term=6397 "PRELID4A, SEC14L" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040270 6397 SEC14L1 http://www.ncbi.nlm.nih.gov/gene/?term=6397 "PRELID4A, SEC14L" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040271 63971 KIF13A http://www.ncbi.nlm.nih.gov/gene/?term=63971 "RBKIN, bA500C11.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040272 63971 KIF13A http://www.ncbi.nlm.nih.gov/gene/?term=63971 "RBKIN, bA500C11.2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040273 63976 PRDM16 http://www.ncbi.nlm.nih.gov/gene/?term=63976 "CMD1LL, KMT8F, LVNC8, MEL1, PFM13" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040274 63976 PRDM16 http://www.ncbi.nlm.nih.gov/gene/?term=63976 "CMD1LL, KMT8F, LVNC8, MEL1, PFM13" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040275 64067 NPAS3 http://www.ncbi.nlm.nih.gov/gene/?term=64067 "MOP6, PASD6, bHLHe12" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040276 64067 NPAS3 http://www.ncbi.nlm.nih.gov/gene/?term=64067 "MOP6, PASD6, bHLHe12" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040277 64081 PBLD http://www.ncbi.nlm.nih.gov/gene/?term=64081 "HEL-S-306, MAWBP, MAWDBP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040278 64081 PBLD http://www.ncbi.nlm.nih.gov/gene/?term=64081 "HEL-S-306, MAWBP, MAWDBP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040279 64083 GOLPH3 http://www.ncbi.nlm.nih.gov/gene/?term=64083 "GOPP1, GPP34, MIDAS, Vps74" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040280 64083 GOLPH3 http://www.ncbi.nlm.nih.gov/gene/?term=64083 "GOPP1, GPP34, MIDAS, Vps74" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040281 64087 MCCC2 http://www.ncbi.nlm.nih.gov/gene/?term=64087 MCCB mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040282 64087 MCCC2 http://www.ncbi.nlm.nih.gov/gene/?term=64087 MCCB mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040283 64097 EPB41L4A http://www.ncbi.nlm.nih.gov/gene/?term=64097 "EPB41L4, NBL4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040284 64097 EPB41L4A http://www.ncbi.nlm.nih.gov/gene/?term=64097 "EPB41L4, NBL4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040285 64101 LRRC4 http://www.ncbi.nlm.nih.gov/gene/?term=64101 "NAG14, NGL-2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040286 64101 LRRC4 http://www.ncbi.nlm.nih.gov/gene/?term=64101 "NAG14, NGL-2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040287 64115 VSIR http://www.ncbi.nlm.nih.gov/gene/?term=64115 "B7-H5, B7H5, C10orf54, DD1alpha, GI24, PD-1H, PP2135, SISP1, VISTA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040288 64115 VSIR http://www.ncbi.nlm.nih.gov/gene/?term=64115 "B7-H5, B7H5, C10orf54, DD1alpha, GI24, PD-1H, PP2135, SISP1, VISTA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040289 64116 SLC39A8 http://www.ncbi.nlm.nih.gov/gene/?term=64116 "BIGM103, CDG2N, LZT-Hs6, PP3105, ZIP8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040290 64116 SLC39A8 http://www.ncbi.nlm.nih.gov/gene/?term=64116 "BIGM103, CDG2N, LZT-Hs6, PP3105, ZIP8" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040291 64122 FN3K http://www.ncbi.nlm.nih.gov/gene/?term=64122 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040292 64122 FN3K http://www.ncbi.nlm.nih.gov/gene/?term=64122 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040293 6415 SELENOW http://www.ncbi.nlm.nih.gov/gene/?term=6415 "SEPW1, selW" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040294 6415 SELENOW http://www.ncbi.nlm.nih.gov/gene/?term=6415 "SEPW1, selW" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040295 64172 OSGEPL1 http://www.ncbi.nlm.nih.gov/gene/?term=64172 "OSGEPL, Qri7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040296 6429 SRSF4 http://www.ncbi.nlm.nih.gov/gene/?term=6429 "SFRS4, SRP75" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040297 6429 SRSF4 http://www.ncbi.nlm.nih.gov/gene/?term=6429 "SFRS4, SRP75" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040298 64324 NSD1 http://www.ncbi.nlm.nih.gov/gene/?term=64324 "ARA267, KMT3B, SOTOS, SOTOS1, STO" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040299 64324 NSD1 http://www.ncbi.nlm.nih.gov/gene/?term=64324 "ARA267, KMT3B, SOTOS, SOTOS1, STO" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040300 64327 LMBR1 http://www.ncbi.nlm.nih.gov/gene/?term=64327 "ACHP, C7orf2, DIF14, LSS, PPD2, THYP, TPT, ZRS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040301 64327 LMBR1 http://www.ncbi.nlm.nih.gov/gene/?term=64327 "ACHP, C7orf2, DIF14, LSS, PPD2, THYP, TPT, ZRS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040302 6433 SFSWAP http://www.ncbi.nlm.nih.gov/gene/?term=6433 "SFRS8, SWAP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040303 6433 SFSWAP http://www.ncbi.nlm.nih.gov/gene/?term=6433 "SFRS8, SWAP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040304 643314 KIAA0754 http://www.ncbi.nlm.nih.gov/gene/?term=643314 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040305 643314 KIAA0754 http://www.ncbi.nlm.nih.gov/gene/?term=643314 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040306 64332 NFKBIZ http://www.ncbi.nlm.nih.gov/gene/?term=64332 "IKBZ, INAP, MAIL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040307 64359 NXN http://www.ncbi.nlm.nih.gov/gene/?term=64359 "NRX, TRG-4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040308 64374 SIL1 http://www.ncbi.nlm.nih.gov/gene/?term=64374 "BAP, MSS, ULG5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040309 64374 SIL1 http://www.ncbi.nlm.nih.gov/gene/?term=64374 "BAP, MSS, ULG5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040310 64398 MPP5 http://www.ncbi.nlm.nih.gov/gene/?term=64398 PALS1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040311 64417 TMEM267 http://www.ncbi.nlm.nih.gov/gene/?term=64417 C5orf28 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040312 64417 TMEM267 http://www.ncbi.nlm.nih.gov/gene/?term=64417 C5orf28 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040313 64419 MTMR14 http://www.ncbi.nlm.nih.gov/gene/?term=64419 C3orf29 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040314 64419 MTMR14 http://www.ncbi.nlm.nih.gov/gene/?term=64419 C3orf29 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040315 64430 PCNX4 http://www.ncbi.nlm.nih.gov/gene/?term=64430 "C14orf135, FBP2, PCNXL4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040316 64430 PCNX4 http://www.ncbi.nlm.nih.gov/gene/?term=64430 "C14orf135, FBP2, PCNXL4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040317 64431 ACTR6 http://www.ncbi.nlm.nih.gov/gene/?term=64431 "ARP6, CDA12, HSPC281, MSTP136, hARP6, hARPX" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040318 64431 ACTR6 http://www.ncbi.nlm.nih.gov/gene/?term=64431 "ARP6, CDA12, HSPC281, MSTP136, hARP6, hARPX" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040319 6446 SGK1 http://www.ncbi.nlm.nih.gov/gene/?term=6446 SGK mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040320 6446 SGK1 http://www.ncbi.nlm.nih.gov/gene/?term=6446 SGK mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040321 6453 ITSN1 http://www.ncbi.nlm.nih.gov/gene/?term=6453 "ITSN, SH3D1A, SH3P17" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040322 645513 LOC645513 http://www.ncbi.nlm.nih.gov/gene/?term=645513 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00040323 645513 LOC645513 http://www.ncbi.nlm.nih.gov/gene/?term=645513 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00040324 64743 WDR13 http://www.ncbi.nlm.nih.gov/gene/?term=64743 MG21 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040325 64743 WDR13 http://www.ncbi.nlm.nih.gov/gene/?term=64743 MG21 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040326 64746 ACBD3 http://www.ncbi.nlm.nih.gov/gene/?term=64746 "GCP60, GOCAP1, GOLPH1, PAP7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040327 64746 ACBD3 http://www.ncbi.nlm.nih.gov/gene/?term=64746 "GCP60, GOCAP1, GOLPH1, PAP7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040328 64754 SMYD3 http://www.ncbi.nlm.nih.gov/gene/?term=64754 "KMT3E, ZMYND1, ZNFN3A1, bA74P14.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040329 64754 SMYD3 http://www.ncbi.nlm.nih.gov/gene/?term=64754 "KMT3E, ZMYND1, ZNFN3A1, bA74P14.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040330 64756 ATPAF1 http://www.ncbi.nlm.nih.gov/gene/?term=64756 "ATP11, ATP11p" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040331 64756 ATPAF1 http://www.ncbi.nlm.nih.gov/gene/?term=64756 "ATP11, ATP11p" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040332 64764 CREB3L2 http://www.ncbi.nlm.nih.gov/gene/?term=64764 BBF2H7 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040333 64770 CCDC14 http://www.ncbi.nlm.nih.gov/gene/?term=64770 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040334 64778 FNDC3B http://www.ncbi.nlm.nih.gov/gene/?term=64778 "FAD104, PRO4979, YVTM2421" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040335 64778 FNDC3B http://www.ncbi.nlm.nih.gov/gene/?term=64778 "FAD104, PRO4979, YVTM2421" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040336 64779 MTHFSD http://www.ncbi.nlm.nih.gov/gene/?term=64779 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040337 64779 MTHFSD http://www.ncbi.nlm.nih.gov/gene/?term=64779 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040338 64786 TBC1D15 http://www.ncbi.nlm.nih.gov/gene/?term=64786 RAB7-GAP mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040339 6482 ST3GAL1 http://www.ncbi.nlm.nih.gov/gene/?term=6482 "Gal-NAc6S, SIAT4A, SIATFL, ST3GalA, ST3GalA.1, ST3GalIA, ST3GalIA,1, ST3O" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040340 6482 ST3GAL1 http://www.ncbi.nlm.nih.gov/gene/?term=6482 "Gal-NAc6S, SIAT4A, SIATFL, ST3GalA, ST3GalA.1, ST3GalIA, ST3GalIA,1, ST3O" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040341 6484 ST3GAL4 http://www.ncbi.nlm.nih.gov/gene/?term=6484 "CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST-4, ST3GalA.2, ST3GalIV, STZ, gal-NAc6S" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040342 6484 ST3GAL4 http://www.ncbi.nlm.nih.gov/gene/?term=6484 "CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST-4, ST3GalA.2, ST3GalIV, STZ, gal-NAc6S" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040343 64848 YTHDC2 http://www.ncbi.nlm.nih.gov/gene/?term=64848 CAHL mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040344 64848 YTHDC2 http://www.ncbi.nlm.nih.gov/gene/?term=64848 CAHL mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040345 64854 USP46 http://www.ncbi.nlm.nih.gov/gene/?term=64854 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040346 64854 USP46 http://www.ncbi.nlm.nih.gov/gene/?term=64854 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040347 64855 FAM129B http://www.ncbi.nlm.nih.gov/gene/?term=64855 "C9orf88, MEG-3, MINERVA, OC58, bA356B19.6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040348 64855 FAM129B http://www.ncbi.nlm.nih.gov/gene/?term=64855 "C9orf88, MEG-3, MINERVA, OC58, bA356B19.6" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040349 6487 ST3GAL3 http://www.ncbi.nlm.nih.gov/gene/?term=6487 "EIEE15, MRT12, SIAT6, ST3GALII, ST3Gal III, ST3GalIII, ST3N" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040350 649 BMP1 http://www.ncbi.nlm.nih.gov/gene/?term=649 "OI13, PCOLC, PCP, PCP2, TLD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040351 649 BMP1 http://www.ncbi.nlm.nih.gov/gene/?term=649 "OI13, PCOLC, PCP, PCP2, TLD" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040352 64921 CASD1 http://www.ncbi.nlm.nih.gov/gene/?term=64921 "C7orf12, NBLA04196, SOAT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040353 64924 SLC30A5 http://www.ncbi.nlm.nih.gov/gene/?term=64924 "ZNT5, ZNTL1, ZTL1, ZnT-5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040354 6498 SKIL http://www.ncbi.nlm.nih.gov/gene/?term=6498 "SNO, SnoA, SnoI, SnoN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040355 6498 SKIL http://www.ncbi.nlm.nih.gov/gene/?term=6498 "SNO, SnoA, SnoI, SnoN" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040356 64981 MRPL34 http://www.ncbi.nlm.nih.gov/gene/?term=64981 L34mt mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040357 64981 MRPL34 http://www.ncbi.nlm.nih.gov/gene/?term=64981 L34mt mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040358 6503 SLA http://www.ncbi.nlm.nih.gov/gene/?term=6503 "SLA1P, SLA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040359 6503 SLA http://www.ncbi.nlm.nih.gov/gene/?term=6503 "SLA1P, SLA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040360 65055 REEP1 http://www.ncbi.nlm.nih.gov/gene/?term=65055 "C2orf23, HMN5B, SPG31, Yip2a" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040361 65055 REEP1 http://www.ncbi.nlm.nih.gov/gene/?term=65055 "C2orf23, HMN5B, SPG31, Yip2a" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040362 65056 GPBP1 http://www.ncbi.nlm.nih.gov/gene/?term=65056 "GPBP, SSH6, VASCULIN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040363 6507 SLC1A3 http://www.ncbi.nlm.nih.gov/gene/?term=6507 "EA6, EAAT1, GLAST, GLAST1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040364 6507 SLC1A3 http://www.ncbi.nlm.nih.gov/gene/?term=6507 "EA6, EAAT1, GLAST, GLAST1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040365 65125 WNK1 http://www.ncbi.nlm.nih.gov/gene/?term=65125 "HSAN2, HSN2, KDP, PPP1R167, PRKWNK1, PSK, p65" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040366 6522 SLC4A2 http://www.ncbi.nlm.nih.gov/gene/?term=6522 "AE2, BND3L, EPB3L1, HKB3, NBND3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040367 6522 SLC4A2 http://www.ncbi.nlm.nih.gov/gene/?term=6522 "AE2, BND3L, EPB3L1, HKB3, NBND3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040368 65268 WNK2 http://www.ncbi.nlm.nih.gov/gene/?term=65268 "NY-CO-43, P/OKcl.13, PRKWNK2, SDCCAG43" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040369 654433 PAX8-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=654433 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00040370 654433 PAX8-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=654433 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00040371 6546 SLC8A1 http://www.ncbi.nlm.nih.gov/gene/?term=6546 NCX1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040372 6546 SLC8A1 http://www.ncbi.nlm.nih.gov/gene/?term=6546 NCX1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040373 6558 SLC12A2 http://www.ncbi.nlm.nih.gov/gene/?term=6558 "BSC, BSC2, NKCC1, PPP1R141" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040374 6573 SLC19A1 http://www.ncbi.nlm.nih.gov/gene/?term=6573 "CHMD, FOLT, IFC1, REFC, RFC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040375 659 BMPR2 http://www.ncbi.nlm.nih.gov/gene/?term=659 "BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040376 6595 SMARCA2 http://www.ncbi.nlm.nih.gov/gene/?term=6595 "BAF190, BRM, NCBRS, SNF2, SNF2L2, SNF2LA, SWI2, Sth1p, hBRM, hSNF2a" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040377 65983 GRAMD2B http://www.ncbi.nlm.nih.gov/gene/?term=65983 "GRAMD3, NS3TP2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040378 65983 GRAMD2B http://www.ncbi.nlm.nih.gov/gene/?term=65983 "GRAMD3, NS3TP2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040379 6599 SMARCC1 http://www.ncbi.nlm.nih.gov/gene/?term=6599 "BAF155, CRACC1, Rsc8, SRG3, SWI3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040380 66005 CHID1 http://www.ncbi.nlm.nih.gov/gene/?term=66005 "GL008, SI-CLP, SICLP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040381 66005 CHID1 http://www.ncbi.nlm.nih.gov/gene/?term=66005 "GL008, SI-CLP, SICLP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040382 664 BNIP3 http://www.ncbi.nlm.nih.gov/gene/?term=664 NIP3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040383 6643 SNX2 http://www.ncbi.nlm.nih.gov/gene/?term=6643 TRG-9 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040384 6646 SOAT1 http://www.ncbi.nlm.nih.gov/gene/?term=6646 "ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040385 6646 SOAT1 http://www.ncbi.nlm.nih.gov/gene/?term=6646 "ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040386 6648 SOD2 http://www.ncbi.nlm.nih.gov/gene/?term=6648 "IPO-B, IPOB, MNSOD, MVCD6, Mn-SOD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040387 6651 SON http://www.ncbi.nlm.nih.gov/gene/?term=6651 "BASS1, C21orf50, DBP-5, NREBP3, TOKIMS, SON" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040388 6651 SON http://www.ncbi.nlm.nih.gov/gene/?term=6651 "BASS1, C21orf50, DBP-5, NREBP3, TOKIMS, SON" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040389 6687 SPG7 http://www.ncbi.nlm.nih.gov/gene/?term=6687 "CAR, CMAR, PGN, SPG5C" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040390 6687 SPG7 http://www.ncbi.nlm.nih.gov/gene/?term=6687 "CAR, CMAR, PGN, SPG5C" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040391 6688 SPI1 http://www.ncbi.nlm.nih.gov/gene/?term=6688 "OF, PU.1, SFPI1, SPI-1, SPI-A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040392 6688 SPI1 http://www.ncbi.nlm.nih.gov/gene/?term=6688 "OF, PU.1, SFPI1, SPI-1, SPI-A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040393 6695 SPOCK1 http://www.ncbi.nlm.nih.gov/gene/?term=6695 "SPOCK, TESTICAN, TIC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040394 6695 SPOCK1 http://www.ncbi.nlm.nih.gov/gene/?term=6695 "SPOCK, TESTICAN, TIC1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040395 671 BPI http://www.ncbi.nlm.nih.gov/gene/?term=671 "BPIFD1, rBPI" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040396 671 BPI http://www.ncbi.nlm.nih.gov/gene/?term=671 "BPIFD1, rBPI" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040397 6711 SPTBN1 http://www.ncbi.nlm.nih.gov/gene/?term=6711 "ELF, HEL102, SPTB2, betaSpII" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040398 6711 SPTBN1 http://www.ncbi.nlm.nih.gov/gene/?term=6711 "ELF, HEL102, SPTB2, betaSpII" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040399 6717 SRI http://www.ncbi.nlm.nih.gov/gene/?term=6717 "CP-22, CP22, SCN, V19" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040400 6721 SREBF2 http://www.ncbi.nlm.nih.gov/gene/?term=6721 "SREBP-2, SREBP2, bHLHd2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040401 6721 SREBF2 http://www.ncbi.nlm.nih.gov/gene/?term=6721 "SREBP-2, SREBP2, bHLHd2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040402 6729 SRP54 http://www.ncbi.nlm.nih.gov/gene/?term=6729 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040403 6729 SRP54 http://www.ncbi.nlm.nih.gov/gene/?term=6729 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040404 673 BRAF http://www.ncbi.nlm.nih.gov/gene/?term=673 "B-RAF1, B-raf1, NS7, RAFB1, BRAF" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040405 673 BRAF http://www.ncbi.nlm.nih.gov/gene/?term=673 "B-RAF1, B-raf1, NS7, RAFB1, BRAF" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040406 6733 SRPK2 http://www.ncbi.nlm.nih.gov/gene/?term=6733 SFRSK2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040407 6733 SRPK2 http://www.ncbi.nlm.nih.gov/gene/?term=6733 SFRSK2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040408 6777 STAT5B http://www.ncbi.nlm.nih.gov/gene/?term=6777 STAT5 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040409 6780 STAU1 http://www.ncbi.nlm.nih.gov/gene/?term=6780 "PPP1R150, STAU" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040410 6780 STAU1 http://www.ncbi.nlm.nih.gov/gene/?term=6780 "PPP1R150, STAU" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040411 6790 AURKA http://www.ncbi.nlm.nih.gov/gene/?term=6790 "AIK, ARK1, AURA, BTAK, PPP1R47, STK15, STK6, STK7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040412 6792 CDKL5 http://www.ncbi.nlm.nih.gov/gene/?term=6792 "CFAP247, EIEE2, ISSX, STK9" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040413 6793 STK10 http://www.ncbi.nlm.nih.gov/gene/?term=6793 "LOK, PRO2729" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040414 6793 STK10 http://www.ncbi.nlm.nih.gov/gene/?term=6793 "LOK, PRO2729" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040415 6811 STX5 http://www.ncbi.nlm.nih.gov/gene/?term=6811 "SED5A, STX5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040416 6812 STXBP1 http://www.ncbi.nlm.nih.gov/gene/?term=6812 "MUNC18-1, NSEC1, P67, RBSEC1, UNC18" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040417 6812 STXBP1 http://www.ncbi.nlm.nih.gov/gene/?term=6812 "MUNC18-1, NSEC1, P67, RBSEC1, UNC18" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040418 6827 SUPT4H1 http://www.ncbi.nlm.nih.gov/gene/?term=6827 "SPT4, SPT4H, SUPT4H, Supt4a" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040419 6827 SUPT4H1 http://www.ncbi.nlm.nih.gov/gene/?term=6827 "SPT4, SPT4H, SUPT4H, Supt4a" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040420 683 BST1 http://www.ncbi.nlm.nih.gov/gene/?term=683 CD157 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040421 6840 SVIL http://www.ncbi.nlm.nih.gov/gene/?term=6840 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040422 6840 SVIL http://www.ncbi.nlm.nih.gov/gene/?term=6840 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040423 6857 SYT1 http://www.ncbi.nlm.nih.gov/gene/?term=6857 "P65, SVP65, SYT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040424 6865 TACR2 http://www.ncbi.nlm.nih.gov/gene/?term=6865 "NK2R, NKNAR, SKR, TAC2R" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040425 6865 TACR2 http://www.ncbi.nlm.nih.gov/gene/?term=6865 "NK2R, NKNAR, SKR, TAC2R" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040426 6868 ADAM17 http://www.ncbi.nlm.nih.gov/gene/?term=6868 "ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040427 6868 ADAM17 http://www.ncbi.nlm.nih.gov/gene/?term=6868 "ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040428 6894 TARBP1 http://www.ncbi.nlm.nih.gov/gene/?term=6894 "TRM3, TRMT3, TRP-185, TRP185" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040429 6902 TBCA http://www.ncbi.nlm.nih.gov/gene/?term=6902 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040430 6902 TBCA http://www.ncbi.nlm.nih.gov/gene/?term=6902 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040431 6904 TBCD http://www.ncbi.nlm.nih.gov/gene/?term=6904 "PEBAT, SSD-1, tfcD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040432 6907 TBL1X http://www.ncbi.nlm.nih.gov/gene/?term=6907 "EBI, SMAP55, TBL1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040433 6916 TBXAS1 http://www.ncbi.nlm.nih.gov/gene/?term=6916 "BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040434 6916 TBXAS1 http://www.ncbi.nlm.nih.gov/gene/?term=6916 "BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040435 6920 TCEA3 http://www.ncbi.nlm.nih.gov/gene/?term=6920 "TFIIS, TFIIS.H" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040436 6920 TCEA3 http://www.ncbi.nlm.nih.gov/gene/?term=6920 "TFIIS, TFIIS.H" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040437 6934 TCF7L2 http://www.ncbi.nlm.nih.gov/gene/?term=6934 "TCF-4, TCF4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040438 6934 TCF7L2 http://www.ncbi.nlm.nih.gov/gene/?term=6934 "TCF-4, TCF4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040439 6935 ZEB1 http://www.ncbi.nlm.nih.gov/gene/?term=6935 "AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040440 6936 GCFC2 http://www.ncbi.nlm.nih.gov/gene/?term=6936 "C2orf3, DNABF, GCF, TCF9" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040441 6936 GCFC2 http://www.ncbi.nlm.nih.gov/gene/?term=6936 "C2orf3, DNABF, GCF, TCF9" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040442 6938 TCF12 http://www.ncbi.nlm.nih.gov/gene/?term=6938 "CRS3, HEB, HTF4, HsT17266, TCF-12, bHLHb20" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040443 6942 TCF20 http://www.ncbi.nlm.nih.gov/gene/?term=6942 "AR1, SPBP, TCF-20" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040444 6942 TCF20 http://www.ncbi.nlm.nih.gov/gene/?term=6942 "AR1, SPBP, TCF-20" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040445 6993 DYNLT1 http://www.ncbi.nlm.nih.gov/gene/?term=6993 "CW-1, TCTEL1, tctex-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040446 6993 DYNLT1 http://www.ncbi.nlm.nih.gov/gene/?term=6993 "CW-1, TCTEL1, tctex-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040447 6996 TDG http://www.ncbi.nlm.nih.gov/gene/?term=6996 hTDG mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040448 7003 TEAD1 http://www.ncbi.nlm.nih.gov/gene/?term=7003 "AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040449 7003 TEAD1 http://www.ncbi.nlm.nih.gov/gene/?term=7003 "AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040450 7004 TEAD4 http://www.ncbi.nlm.nih.gov/gene/?term=7004 "EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040451 7009 TMBIM6 http://www.ncbi.nlm.nih.gov/gene/?term=7009 "BAXI1, BI-1, TEGT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040452 7009 TMBIM6 http://www.ncbi.nlm.nih.gov/gene/?term=7009 "BAXI1, BI-1, TEGT" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040453 7020 TFAP2A http://www.ncbi.nlm.nih.gov/gene/?term=7020 "AP-2, AP-2alpha, AP2TF, BOFS, TFAP2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040454 7020 TFAP2A http://www.ncbi.nlm.nih.gov/gene/?term=7020 "AP-2, AP-2alpha, AP2TF, BOFS, TFAP2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040455 7024 TFCP2 http://www.ncbi.nlm.nih.gov/gene/?term=7024 "LBP1C, LSF, LSF1D, SEFC, TFCP2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040456 7024 TFCP2 http://www.ncbi.nlm.nih.gov/gene/?term=7024 "LBP1C, LSF, LSF1D, SEFC, TFCP2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040457 7038 TG http://www.ncbi.nlm.nih.gov/gene/?term=7038 "AITD3N, TG" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040458 7038 TG http://www.ncbi.nlm.nih.gov/gene/?term=7038 "AITD3N, TG" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040459 7040 TGFB1 http://www.ncbi.nlm.nih.gov/gene/?term=7040 "CED, DPD1, LAP, TGFB, TGFbeta" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040460 7040 TGFB1 http://www.ncbi.nlm.nih.gov/gene/?term=7040 "CED, DPD1, LAP, TGFB, TGFbeta" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040461 7045 TGFBI http://www.ncbi.nlm.nih.gov/gene/?term=7045 "BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040462 7049 TGFBR3 http://www.ncbi.nlm.nih.gov/gene/?term=7049 "BGCAN, betaglycan" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040463 7049 TGFBR3 http://www.ncbi.nlm.nih.gov/gene/?term=7049 "BGCAN, betaglycan" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040464 7052 TGM2 http://www.ncbi.nlm.nih.gov/gene/?term=7052 "TG(C), TGC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040465 706 TSPO http://www.ncbi.nlm.nih.gov/gene/?term=706 "BPBS, BZRP, DBI, IBP, MBR, PBR, PBS, PKBS, PTBR, mDRC, pk18" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040466 706 TSPO http://www.ncbi.nlm.nih.gov/gene/?term=706 "BPBS, BZRP, DBI, IBP, MBR, PBR, PBS, PKBS, PTBR, mDRC, pk18" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040467 7068 THRB http://www.ncbi.nlm.nih.gov/gene/?term=7068 "C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR11, THRB2, THRB" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040468 7068 THRB http://www.ncbi.nlm.nih.gov/gene/?term=7068 "C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR11, THRB2, THRB" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040469 7072 TIA1 http://www.ncbi.nlm.nih.gov/gene/?term=7072 "TIA-1, WDM" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040470 7072 TIA1 http://www.ncbi.nlm.nih.gov/gene/?term=7072 "TIA-1, WDM" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040471 7074 TIAM1 http://www.ncbi.nlm.nih.gov/gene/?term=7074 TIAM-1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040472 7074 TIAM1 http://www.ncbi.nlm.nih.gov/gene/?term=7074 TIAM-1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040473 7078 TIMP3 http://www.ncbi.nlm.nih.gov/gene/?term=7078 "HSMRK222, K222, K222TA2, SFD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040474 7078 TIMP3 http://www.ncbi.nlm.nih.gov/gene/?term=7078 "HSMRK222, K222, K222TA2, SFD" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040475 7082 TJP1 http://www.ncbi.nlm.nih.gov/gene/?term=7082 ZO-1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040476 7082 TJP1 http://www.ncbi.nlm.nih.gov/gene/?term=7082 ZO-1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040477 7091 TLE4 http://www.ncbi.nlm.nih.gov/gene/?term=7091 "BCE-1, BCE1, E(spI), ESG, ESG4, GRG4, Grg-4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040478 7091 TLE4 http://www.ncbi.nlm.nih.gov/gene/?term=7091 "BCE-1, BCE1, E(spI), ESG, ESG4, GRG4, Grg-4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040479 7145 TNS1 http://www.ncbi.nlm.nih.gov/gene/?term=7145 "MST091, MST122, MST127, MSTP091, MSTP122, MSTP127, MXRA6, PPP1R155, TNS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040480 7145 TNS1 http://www.ncbi.nlm.nih.gov/gene/?term=7145 "MST091, MST122, MST127, MSTP091, MSTP122, MSTP127, MXRA6, PPP1R155, TNS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040481 7150 TOP1 http://www.ncbi.nlm.nih.gov/gene/?term=7150 TOPI mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040482 7150 TOP1 http://www.ncbi.nlm.nih.gov/gene/?term=7150 TOPI mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040483 716 C1S http://www.ncbi.nlm.nih.gov/gene/?term=716 EDSPD2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040484 7163 TPD52 http://www.ncbi.nlm.nih.gov/gene/?term=7163 "D52, N8L, PC-1, PrLZ, hD52" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040485 7163 TPD52 http://www.ncbi.nlm.nih.gov/gene/?term=7163 "D52, N8L, PC-1, PrLZ, hD52" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040486 7168 TPM1 http://www.ncbi.nlm.nih.gov/gene/?term=7168 "C15orf13, CMD1Y, CMH3, HEL-S-265, HTM-alpha, LVNC9, TMSA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040487 7170 TPM3 http://www.ncbi.nlm.nih.gov/gene/?term=7170 "CAPM1, CFTD, HEL-189, HEL-S-82p, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TM5, TPMsk3, TRK, hscp30" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040488 7170 TPM3 http://www.ncbi.nlm.nih.gov/gene/?term=7170 "CAPM1, CFTD, HEL-189, HEL-S-82p, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TM5, TPMsk3, TRK, hscp30" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040489 7171 TPM4 http://www.ncbi.nlm.nih.gov/gene/?term=7171 HEL-S-108 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040490 7171 TPM4 http://www.ncbi.nlm.nih.gov/gene/?term=7171 HEL-S-108 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040491 7182 NR2C2 http://www.ncbi.nlm.nih.gov/gene/?term=7182 "TAK1, TR4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040492 7182 NR2C2 http://www.ncbi.nlm.nih.gov/gene/?term=7182 "TAK1, TR4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040493 7204 TRIO http://www.ncbi.nlm.nih.gov/gene/?term=7204 "ARHGEF23, MEBAS, MRD44, tgat" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040494 7204 TRIO http://www.ncbi.nlm.nih.gov/gene/?term=7204 "ARHGEF23, MEBAS, MRD44, tgat" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040495 7226 TRPM2 http://www.ncbi.nlm.nih.gov/gene/?term=7226 "EREG1, KNP3, LTRPC2, LTrpC-2, NUDT9H, NUDT9L1, TRPC7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040496 7226 TRPM2 http://www.ncbi.nlm.nih.gov/gene/?term=7226 "EREG1, KNP3, LTRPC2, LTrpC-2, NUDT9H, NUDT9L1, TRPC7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040497 7227 TRPS1 http://www.ncbi.nlm.nih.gov/gene/?term=7227 "GC79, LGCR" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040498 7227 TRPS1 http://www.ncbi.nlm.nih.gov/gene/?term=7227 "GC79, LGCR" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040499 726 CAPN5 http://www.ncbi.nlm.nih.gov/gene/?term=726 "ADNIV, HTRA3, VRNI, nCL-3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040500 7265 TTC1 http://www.ncbi.nlm.nih.gov/gene/?term=7265 TPR1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040501 7265 TTC1 http://www.ncbi.nlm.nih.gov/gene/?term=7265 TPR1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040502 7267 TTC3 http://www.ncbi.nlm.nih.gov/gene/?term=7267 "DCRR1, RNF105, TPRDIII" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040503 7294 TXK http://www.ncbi.nlm.nih.gov/gene/?term=7294 "BTKL, PSCTK5, PTK4, RLK, TKL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040504 7295 TXN http://www.ncbi.nlm.nih.gov/gene/?term=7295 "TRDX, TRX, TRX1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040505 7297 TYK2 http://www.ncbi.nlm.nih.gov/gene/?term=7297 "IMD35, JTK1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040506 7297 TYK2 http://www.ncbi.nlm.nih.gov/gene/?term=7297 "IMD35, JTK1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040507 730094 C16orf52 http://www.ncbi.nlm.nih.gov/gene/?term=730094 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040508 730094 C16orf52 http://www.ncbi.nlm.nih.gov/gene/?term=730094 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040509 7319 UBE2A http://www.ncbi.nlm.nih.gov/gene/?term=7319 "HHR6A, MRXS30, MRXSN, RAD6A, UBC2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040510 7320 UBE2B http://www.ncbi.nlm.nih.gov/gene/?term=7320 "E2-17kDa, HHR6B, HR6B, RAD6B, UBC2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040511 7323 UBE2D3 http://www.ncbi.nlm.nih.gov/gene/?term=7323 "E2(17)KB3, UBC4/5, UBCH5C" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040512 7328 UBE2H http://www.ncbi.nlm.nih.gov/gene/?term=7328 "E2-20K, GID3, UBC8, UBCH, UBCH2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040513 7328 UBE2H http://www.ncbi.nlm.nih.gov/gene/?term=7328 "E2-20K, GID3, UBC8, UBCH, UBCH2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040514 7332 UBE2L3 http://www.ncbi.nlm.nih.gov/gene/?term=7332 "E2-F1, L-UBC, UBCH7, UbcM4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040515 7332 UBE2L3 http://www.ncbi.nlm.nih.gov/gene/?term=7332 "E2-F1, L-UBC, UBCH7, UbcM4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040516 7337 UBE3A http://www.ncbi.nlm.nih.gov/gene/?term=7337 "ANCR, AS, E6-AP, EPVE6AP, HPVE6A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040517 7360 UGP2 http://www.ncbi.nlm.nih.gov/gene/?term=7360 "UDPG, UDPGP, UDPGP2, UGP1, UGPP1, UGPP2, pHC379" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040518 7371 UCK2 http://www.ncbi.nlm.nih.gov/gene/?term=7371 "TSA903, UK, UMPK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040519 7374 UNG http://www.ncbi.nlm.nih.gov/gene/?term=7374 "DGU, HIGM4, HIGM5, UDG1, UNG15, UNG2, UNG" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040520 7374 UNG http://www.ncbi.nlm.nih.gov/gene/?term=7374 "DGU, HIGM4, HIGM5, UDG1, UNG15, UNG2, UNG" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040521 7388 UQCRH http://www.ncbi.nlm.nih.gov/gene/?term=7388 "QCR6, UQCR8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040522 7388 UQCRH http://www.ncbi.nlm.nih.gov/gene/?term=7388 "QCR6, UQCR8" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040523 7390 UROS http://www.ncbi.nlm.nih.gov/gene/?term=7390 UROIIIS mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040524 7390 UROS http://www.ncbi.nlm.nih.gov/gene/?term=7390 UROIIIS mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040525 7410 VAV2 http://www.ncbi.nlm.nih.gov/gene/?term=7410 VAV-2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040526 7410 VAV2 http://www.ncbi.nlm.nih.gov/gene/?term=7410 VAV-2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040527 7414 VCL http://www.ncbi.nlm.nih.gov/gene/?term=7414 "CMD1W, CMH15, HEL114, MV, MVCL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040528 7461 CLIP2 http://www.ncbi.nlm.nih.gov/gene/?term=7461 "CLIP, CLIP-115, CYLN2, WBSCR3, WBSCR4, WSCR3, WSCR4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040529 7461 CLIP2 http://www.ncbi.nlm.nih.gov/gene/?term=7461 "CLIP, CLIP-115, CYLN2, WBSCR3, WBSCR4, WSCR3, WSCR4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040530 7468 NSD2 http://www.ncbi.nlm.nih.gov/gene/?term=7468 "KMT3F, KMT3G, MMSET, REIIBP, TRX5, WHS, WHSC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040531 7485 WRB http://www.ncbi.nlm.nih.gov/gene/?term=7485 "CHD5, GET1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040532 7508 XPC http://www.ncbi.nlm.nih.gov/gene/?term=7508 "RAD4, XP3C, p125, XPC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040533 7508 XPC http://www.ncbi.nlm.nih.gov/gene/?term=7508 "RAD4, XP3C, p125, XPC" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040534 7520 XRCC5 http://www.ncbi.nlm.nih.gov/gene/?term=7520 "KARP-1, KARP1, KU80, KUB2, Ku86, NFIV" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040535 7520 XRCC5 http://www.ncbi.nlm.nih.gov/gene/?term=7520 "KARP-1, KARP1, KU80, KUB2, Ku86, NFIV" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040536 7525 YES1 http://www.ncbi.nlm.nih.gov/gene/?term=7525 "HsT441, P61-YES, Yes, c-yes" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040537 7528 YY1 http://www.ncbi.nlm.nih.gov/gene/?term=7528 "DELTA, GADEVS, INO80S, NF-E1, UCRBP, YIN-YANG-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040538 7528 YY1 http://www.ncbi.nlm.nih.gov/gene/?term=7528 "DELTA, GADEVS, INO80S, NF-E1, UCRBP, YIN-YANG-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040539 753 LDLRAD4 http://www.ncbi.nlm.nih.gov/gene/?term=753 C18orf1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040540 753 LDLRAD4 http://www.ncbi.nlm.nih.gov/gene/?term=753 C18orf1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040541 7531 YWHAE http://www.ncbi.nlm.nih.gov/gene/?term=7531 "14-3-3E, HEL2, KCIP-1, MDCR, MDS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040542 7531 YWHAE http://www.ncbi.nlm.nih.gov/gene/?term=7531 "14-3-3E, HEL2, KCIP-1, MDCR, MDS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040543 7534 YWHAZ http://www.ncbi.nlm.nih.gov/gene/?term=7534 "14-3-3-zeta, HEL-S-3, HEL-S-93, HEL4, KCIP-1, YWHAD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040544 7534 YWHAZ http://www.ncbi.nlm.nih.gov/gene/?term=7534 "14-3-3-zeta, HEL-S-3, HEL-S-93, HEL4, KCIP-1, YWHAD" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040545 7541 ZBTB14 http://www.ncbi.nlm.nih.gov/gene/?term=7541 "ZF5, ZFP-161, ZFP-5, ZFP161, ZNF478" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040546 7541 ZBTB14 http://www.ncbi.nlm.nih.gov/gene/?term=7541 "ZF5, ZFP-161, ZFP-5, ZFP161, ZNF478" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040547 7556 ZNF10 http://www.ncbi.nlm.nih.gov/gene/?term=7556 KOX1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040548 7586 ZKSCAN1 http://www.ncbi.nlm.nih.gov/gene/?term=7586 "KOX18, PHZ-37, ZNF139, ZNF36, ZSCAN33" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040549 7629 ZNF76 http://www.ncbi.nlm.nih.gov/gene/?term=7629 "D6S229E, ZNF523, Zfp523" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040550 7629 ZNF76 http://www.ncbi.nlm.nih.gov/gene/?term=7629 "D6S229E, ZNF523, Zfp523" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040551 7678 ZNF124 http://www.ncbi.nlm.nih.gov/gene/?term=7678 "HZF-16, HZF16, ZK7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040552 7678 ZNF124 http://www.ncbi.nlm.nih.gov/gene/?term=7678 "HZF-16, HZF16, ZK7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040553 7704 ZBTB16 http://www.ncbi.nlm.nih.gov/gene/?term=7704 "PLZF, ZNF145" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040554 7704 ZBTB16 http://www.ncbi.nlm.nih.gov/gene/?term=7704 "PLZF, ZNF145" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040555 7706 TRIM25 http://www.ncbi.nlm.nih.gov/gene/?term=7706 "EFP, RNF147, Z147, ZNF147" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040556 7706 TRIM25 http://www.ncbi.nlm.nih.gov/gene/?term=7706 "EFP, RNF147, Z147, ZNF147" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040557 776 CACNA1D http://www.ncbi.nlm.nih.gov/gene/?term=776 "CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, PASNA, SANDD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040558 776 CACNA1D http://www.ncbi.nlm.nih.gov/gene/?term=776 "CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, PASNA, SANDD" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040559 7776 ZNF236 http://www.ncbi.nlm.nih.gov/gene/?term=7776 "ZNF236AB, ZNF236" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040560 781 CACNA2D1 http://www.ncbi.nlm.nih.gov/gene/?term=781 "CACNA2, CACNL2A, CCHL2A, LINC01112, lncRNA-N3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040561 7869 SEMA3B http://www.ncbi.nlm.nih.gov/gene/?term=7869 "LUCA-1, SEMA5, SEMAA, SemA, semaV" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040562 7869 SEMA3B http://www.ncbi.nlm.nih.gov/gene/?term=7869 "LUCA-1, SEMA5, SEMAA, SemA, semaV" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040563 7871 SLMAP http://www.ncbi.nlm.nih.gov/gene/?term=7871 SLAP mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040564 7871 SLMAP http://www.ncbi.nlm.nih.gov/gene/?term=7871 SLAP mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040565 78991 PCYOX1L http://www.ncbi.nlm.nih.gov/gene/?term=78991 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040566 78991 PCYOX1L http://www.ncbi.nlm.nih.gov/gene/?term=78991 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040567 79018 GID4 http://www.ncbi.nlm.nih.gov/gene/?term=79018 "C17orf39, VID24" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040568 79018 GID4 http://www.ncbi.nlm.nih.gov/gene/?term=79018 "C17orf39, VID24" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040569 7905 REEP5 http://www.ncbi.nlm.nih.gov/gene/?term=7905 "C5orf18, D5S346, DP1, TB2, YOP1, Yip2e" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040570 79083 MLPH http://www.ncbi.nlm.nih.gov/gene/?term=79083 SLAC2-A mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040571 79083 MLPH http://www.ncbi.nlm.nih.gov/gene/?term=79083 SLAC2-A mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040572 79091 METTL22 http://www.ncbi.nlm.nih.gov/gene/?term=79091 C16orf68 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040573 79091 METTL22 http://www.ncbi.nlm.nih.gov/gene/?term=79091 C16orf68 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040574 79158 GNPTAB http://www.ncbi.nlm.nih.gov/gene/?term=79158 "GNPTA, ICD" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040575 79158 GNPTAB http://www.ncbi.nlm.nih.gov/gene/?term=79158 "GNPTA, ICD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040576 79573 TTC13 http://www.ncbi.nlm.nih.gov/gene/?term=79573 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040577 79577 CDC73 http://www.ncbi.nlm.nih.gov/gene/?term=79577 "C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040578 79577 CDC73 http://www.ncbi.nlm.nih.gov/gene/?term=79577 "C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040579 79596 RNF219 http://www.ncbi.nlm.nih.gov/gene/?term=79596 C13orf7 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040580 79596 RNF219 http://www.ncbi.nlm.nih.gov/gene/?term=79596 C13orf7 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040581 79618 HMBOX1 http://www.ncbi.nlm.nih.gov/gene/?term=79618 "HNF1LA, HOT1, PBHNF" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040582 79618 HMBOX1 http://www.ncbi.nlm.nih.gov/gene/?term=79618 "HNF1LA, HOT1, PBHNF" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040583 79639 TMEM53 http://www.ncbi.nlm.nih.gov/gene/?term=79639 NET4 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040584 79639 TMEM53 http://www.ncbi.nlm.nih.gov/gene/?term=79639 NET4 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040585 79648 MCPH1 http://www.ncbi.nlm.nih.gov/gene/?term=79648 "BRIT1, MCT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040586 79648 MCPH1 http://www.ncbi.nlm.nih.gov/gene/?term=79648 "BRIT1, MCT" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040587 79658 ARHGAP10 http://www.ncbi.nlm.nih.gov/gene/?term=79658 "GRAF2, PS-GAP, PSGAP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040588 79658 ARHGAP10 http://www.ncbi.nlm.nih.gov/gene/?term=79658 "GRAF2, PS-GAP, PSGAP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040589 79668 PARP8 http://www.ncbi.nlm.nih.gov/gene/?term=79668 "ARTD16, pART16" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040590 79675 FASTKD1 http://www.ncbi.nlm.nih.gov/gene/?term=79675 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040591 79677 SMC6 http://www.ncbi.nlm.nih.gov/gene/?term=79677 "SMC-6L1, hSMC6, SMC6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040592 79684 MSANTD2 http://www.ncbi.nlm.nih.gov/gene/?term=79684 C11orf61 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040593 79701 OGFOD3 http://www.ncbi.nlm.nih.gov/gene/?term=79701 C17orf101 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040594 79701 OGFOD3 http://www.ncbi.nlm.nih.gov/gene/?term=79701 C17orf101 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040595 79705 LRRK1 http://www.ncbi.nlm.nih.gov/gene/?term=79705 "RIPK6, Roco1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040596 79705 LRRK1 http://www.ncbi.nlm.nih.gov/gene/?term=79705 "RIPK6, Roco1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040597 79709 COLGALT1 http://www.ncbi.nlm.nih.gov/gene/?term=79709 GLT25D1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040598 79709 COLGALT1 http://www.ncbi.nlm.nih.gov/gene/?term=79709 GLT25D1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040599 79712 GTDC1 http://www.ncbi.nlm.nih.gov/gene/?term=79712 "Hmat-Xa, mat-Xa" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040600 79712 GTDC1 http://www.ncbi.nlm.nih.gov/gene/?term=79712 "Hmat-Xa, mat-Xa" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040601 79718 TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/?term=79718 "C21, DC42, IRA1, MRD41, TBLR1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040602 79718 TBL1XR1 http://www.ncbi.nlm.nih.gov/gene/?term=79718 "C21, DC42, IRA1, MRD41, TBLR1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040603 79720 VPS37B http://www.ncbi.nlm.nih.gov/gene/?term=79720 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040604 79720 VPS37B http://www.ncbi.nlm.nih.gov/gene/?term=79720 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040605 79729 SH3D21 http://www.ncbi.nlm.nih.gov/gene/?term=79729 C1orf113 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040606 79729 SH3D21 http://www.ncbi.nlm.nih.gov/gene/?term=79729 C1orf113 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040607 79731 NARS2 http://www.ncbi.nlm.nih.gov/gene/?term=79731 "DFNB94, SLM5, asnRS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040608 79731 NARS2 http://www.ncbi.nlm.nih.gov/gene/?term=79731 "DFNB94, SLM5, asnRS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040609 79746 ECHDC3 http://www.ncbi.nlm.nih.gov/gene/?term=79746 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040610 79746 ECHDC3 http://www.ncbi.nlm.nih.gov/gene/?term=79746 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040611 79752 ZFAND1 http://www.ncbi.nlm.nih.gov/gene/?term=79752 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040612 79752 ZFAND1 http://www.ncbi.nlm.nih.gov/gene/?term=79752 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040613 79753 SNIP1 http://www.ncbi.nlm.nih.gov/gene/?term=79753 "PML1, PMRED" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040614 79753 SNIP1 http://www.ncbi.nlm.nih.gov/gene/?term=79753 "PML1, PMRED" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040615 79807 GSTCD http://www.ncbi.nlm.nih.gov/gene/?term=79807 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040616 79807 GSTCD http://www.ncbi.nlm.nih.gov/gene/?term=79807 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040617 79811 SLTM http://www.ncbi.nlm.nih.gov/gene/?term=79811 Met mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040618 79811 SLTM http://www.ncbi.nlm.nih.gov/gene/?term=79811 Met mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040619 79817 MOB3B http://www.ncbi.nlm.nih.gov/gene/?term=79817 "C9orf35, MOB1D, MOBKL2B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040620 79817 MOB3B http://www.ncbi.nlm.nih.gov/gene/?term=79817 "C9orf35, MOB1D, MOBKL2B" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040621 79823 CAMKMT http://www.ncbi.nlm.nih.gov/gene/?term=79823 "C2orf34, CLNMT, CaM KMT, Cam, KMT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040622 79823 CAMKMT http://www.ncbi.nlm.nih.gov/gene/?term=79823 "C2orf34, CLNMT, CaM KMT, Cam, KMT" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040623 79832 QSER1 http://www.ncbi.nlm.nih.gov/gene/?term=79832 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040624 79837 PIP4K2C http://www.ncbi.nlm.nih.gov/gene/?term=79837 PIP5K2C mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040625 79837 PIP4K2C http://www.ncbi.nlm.nih.gov/gene/?term=79837 PIP5K2C mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040626 79848 CSPP1 http://www.ncbi.nlm.nih.gov/gene/?term=79848 "CSPP, JBTS21" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040627 79866 BORA http://www.ncbi.nlm.nih.gov/gene/?term=79866 C13orf34 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040628 79866 BORA http://www.ncbi.nlm.nih.gov/gene/?term=79866 C13orf34 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040629 79873 NUDT18 http://www.ncbi.nlm.nih.gov/gene/?term=79873 MTH3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040630 79873 NUDT18 http://www.ncbi.nlm.nih.gov/gene/?term=79873 MTH3 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040631 79875 THSD4 http://www.ncbi.nlm.nih.gov/gene/?term=79875 "ADAMTSL-6, ADAMTSL6, FVSY9334, PRO34005" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040632 79877 DCAKD http://www.ncbi.nlm.nih.gov/gene/?term=79877 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040633 79877 DCAKD http://www.ncbi.nlm.nih.gov/gene/?term=79877 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040634 79899 PRR5L http://www.ncbi.nlm.nih.gov/gene/?term=79899 PROTOR2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040635 79899 PRR5L http://www.ncbi.nlm.nih.gov/gene/?term=79899 PROTOR2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040636 79906 MORN1 http://www.ncbi.nlm.nih.gov/gene/?term=79906 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040637 79932 KIAA0319L http://www.ncbi.nlm.nih.gov/gene/?term=79932 "AAVR, AAVRL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040638 79934 COQ8B http://www.ncbi.nlm.nih.gov/gene/?term=79934 "ADCK4, NPHS9" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040639 79934 COQ8B http://www.ncbi.nlm.nih.gov/gene/?term=79934 "ADCK4, NPHS9" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040640 80003 PCNX2 http://www.ncbi.nlm.nih.gov/gene/?term=80003 PCNXL2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040641 80006 TRAPPC13 http://www.ncbi.nlm.nih.gov/gene/?term=80006 C5orf44 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040642 80012 PHC3 http://www.ncbi.nlm.nih.gov/gene/?term=80012 "EDR3, HPH3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040643 80012 PHC3 http://www.ncbi.nlm.nih.gov/gene/?term=80012 "EDR3, HPH3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040644 80014 WWC2 http://www.ncbi.nlm.nih.gov/gene/?term=80014 BOMB mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040645 80014 WWC2 http://www.ncbi.nlm.nih.gov/gene/?term=80014 BOMB mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040646 80017 DGLUCY http://www.ncbi.nlm.nih.gov/gene/?term=80017 C14orf159 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040647 80017 DGLUCY http://www.ncbi.nlm.nih.gov/gene/?term=80017 C14orf159 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040648 80036 TRPM3 http://www.ncbi.nlm.nih.gov/gene/?term=80036 "GON-2, LTRPC3, MLSN2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040649 80055 PGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=80055 "Bst1, ISPD3024, MRT42, SPG67" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040650 80108 ZFP2 http://www.ncbi.nlm.nih.gov/gene/?term=80108 "ZNF751, zfp-2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040651 80108 ZFP2 http://www.ncbi.nlm.nih.gov/gene/?term=80108 "ZNF751, zfp-2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040652 80129 CCDC170 http://www.ncbi.nlm.nih.gov/gene/?term=80129 "C6orf97, bA282P11.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040653 80129 CCDC170 http://www.ncbi.nlm.nih.gov/gene/?term=80129 "C6orf97, bA282P11.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040654 80144 FRAS1 http://www.ncbi.nlm.nih.gov/gene/?term=80144 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040655 80144 FRAS1 http://www.ncbi.nlm.nih.gov/gene/?term=80144 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040656 80145 THOC7 http://www.ncbi.nlm.nih.gov/gene/?term=80145 "NIF3L1BP1, fSAP24, hTREX30" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040657 80149 ZC3H12A http://www.ncbi.nlm.nih.gov/gene/?term=80149 "MCPIP, MCPIP-1, MCPIP1, Reg1, dJ423B22.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040658 80149 ZC3H12A http://www.ncbi.nlm.nih.gov/gene/?term=80149 "MCPIP, MCPIP-1, MCPIP1, Reg1, dJ423B22.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040659 80173 IFT74 http://www.ncbi.nlm.nih.gov/gene/?term=80173 "BBS20, CCDC2, CMG-1, CMG1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040660 80173 IFT74 http://www.ncbi.nlm.nih.gov/gene/?term=80173 "BBS20, CCDC2, CMG-1, CMG1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040661 80184 CEP290 http://www.ncbi.nlm.nih.gov/gene/?term=80184 "3H11Ag, BBS14, CT87, JBTS5, LCA10, MKS4, NPHP6, POC3, SLSN6, rd16" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040662 80184 CEP290 http://www.ncbi.nlm.nih.gov/gene/?term=80184 "3H11Ag, BBS14, CT87, JBTS5, LCA10, MKS4, NPHP6, POC3, SLSN6, rd16" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040663 80204 FBXO11 http://www.ncbi.nlm.nih.gov/gene/?term=80204 "FBX11, PRMT9, UBR6, UG063H01, VIT1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040664 80204 FBXO11 http://www.ncbi.nlm.nih.gov/gene/?term=80204 "FBX11, PRMT9, UBR6, UG063H01, VIT1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040665 80205 CHD9 http://www.ncbi.nlm.nih.gov/gene/?term=80205 "AD013, CHD-9, CReMM, KISH2, PRIC320" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040666 80212 CCDC92 http://www.ncbi.nlm.nih.gov/gene/?term=80212 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040667 80212 CCDC92 http://www.ncbi.nlm.nih.gov/gene/?term=80212 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040668 80218 NAA50 http://www.ncbi.nlm.nih.gov/gene/?term=80218 "MAK3, NAT13, NAT13P, NAT5, NAT5P, SAN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040669 80223 RAB11FIP1 http://www.ncbi.nlm.nih.gov/gene/?term=80223 "NOEL1A, RCP, rab11-FIP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040670 80230 RUFY1 http://www.ncbi.nlm.nih.gov/gene/?term=80230 "RABIP4, ZFYVE12" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040671 80230 RUFY1 http://www.ncbi.nlm.nih.gov/gene/?term=80230 "RABIP4, ZFYVE12" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040672 80232 WDR26 http://www.ncbi.nlm.nih.gov/gene/?term=80232 "CDW2, GID7, MIP2, SKDEAS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040673 80262 C16orf70 http://www.ncbi.nlm.nih.gov/gene/?term=80262 "C16orf6, LIN10, lin-10" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040674 80264 ZNF430 http://www.ncbi.nlm.nih.gov/gene/?term=80264 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040675 8028 MLLT10 http://www.ncbi.nlm.nih.gov/gene/?term=8028 AF10 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040676 8028 MLLT10 http://www.ncbi.nlm.nih.gov/gene/?term=8028 AF10 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040677 80314 EPC1 http://www.ncbi.nlm.nih.gov/gene/?term=80314 Epl1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040678 80314 EPC1 http://www.ncbi.nlm.nih.gov/gene/?term=80314 Epl1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040679 80315 CPEB4 http://www.ncbi.nlm.nih.gov/gene/?term=80315 "CPE-BP4, hCPEB-4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040680 80315 CPEB4 http://www.ncbi.nlm.nih.gov/gene/?term=80315 "CPE-BP4, hCPEB-4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040681 8034 SLC25A16 http://www.ncbi.nlm.nih.gov/gene/?term=8034 "D10S105E, GDA, GDC, HGT.1, ML7, hML7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040682 8034 SLC25A16 http://www.ncbi.nlm.nih.gov/gene/?term=8034 "D10S105E, GDA, GDC, HGT.1, ML7, hML7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040683 8036 SHOC2 http://www.ncbi.nlm.nih.gov/gene/?term=8036 "SIAA0862, SOC2, SUR8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040684 8036 SHOC2 http://www.ncbi.nlm.nih.gov/gene/?term=8036 "SIAA0862, SOC2, SUR8" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040685 8038 ADAM12 http://www.ncbi.nlm.nih.gov/gene/?term=8038 "ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040686 8038 ADAM12 http://www.ncbi.nlm.nih.gov/gene/?term=8038 "ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040687 80745 THUMPD2 http://www.ncbi.nlm.nih.gov/gene/?term=80745 C2orf8 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040688 80745 THUMPD2 http://www.ncbi.nlm.nih.gov/gene/?term=80745 C2orf8 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040689 80746 TSEN2 http://www.ncbi.nlm.nih.gov/gene/?term=80746 "PCH2B, SEN2, SEN2L" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040690 80746 TSEN2 http://www.ncbi.nlm.nih.gov/gene/?term=80746 "PCH2B, SEN2, SEN2L" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040691 80777 CYB5B http://www.ncbi.nlm.nih.gov/gene/?term=80777 "CYB5-M, CYPB5M, OMB5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040692 80777 CYB5B http://www.ncbi.nlm.nih.gov/gene/?term=80777 "CYB5-M, CYPB5M, OMB5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040693 80778 ZNF34 http://www.ncbi.nlm.nih.gov/gene/?term=80778 KOX32 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040694 80778 ZNF34 http://www.ncbi.nlm.nih.gov/gene/?term=80778 KOX32 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040695 80790 CMIP http://www.ncbi.nlm.nih.gov/gene/?term=80790 TCMIP mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040696 80790 CMIP http://www.ncbi.nlm.nih.gov/gene/?term=80790 TCMIP mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040697 80824 DUSP16 http://www.ncbi.nlm.nih.gov/gene/?term=80824 "MKP-7, MKP7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040698 80895 ILKAP http://www.ncbi.nlm.nih.gov/gene/?term=80895 "ILKAP23, PP2C-DELTA, PPM1O, ILKAP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040699 80895 ILKAP http://www.ncbi.nlm.nih.gov/gene/?term=80895 "ILKAP23, PP2C-DELTA, PPM1O, ILKAP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040700 8091 HMGA2 http://www.ncbi.nlm.nih.gov/gene/?term=8091 "BABL, HMGI-C, HMGIC, LIPO, STQTL9" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040701 8091 HMGA2 http://www.ncbi.nlm.nih.gov/gene/?term=8091 "BABL, HMGI-C, HMGIC, LIPO, STQTL9" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040702 81 ACTN4 http://www.ncbi.nlm.nih.gov/gene/?term=81 "ACTININ-4, FSGS, FSGS1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040703 81 ACTN4 http://www.ncbi.nlm.nih.gov/gene/?term=81 "ACTININ-4, FSGS, FSGS1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040704 8128 ST8SIA2 http://www.ncbi.nlm.nih.gov/gene/?term=8128 "HsT19690, SIAT8-B, SIAT8B, ST8SIA-II, ST8SiaII, STX" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040705 8128 ST8SIA2 http://www.ncbi.nlm.nih.gov/gene/?term=8128 "HsT19690, SIAT8-B, SIAT8B, ST8SIA-II, ST8SiaII, STX" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040706 8131 NPRL3 http://www.ncbi.nlm.nih.gov/gene/?term=8131 "C16orf35, CGTHBA, FFEVF3, HS-40, MARE, NPR3, RMD11" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040707 8148 TAF15 http://www.ncbi.nlm.nih.gov/gene/?term=8148 "Npl3, RBP56, TAF2N, TAFII68" lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00040708 8148 TAF15 http://www.ncbi.nlm.nih.gov/gene/?term=8148 "Npl3, RBP56, TAF2N, TAFII68" lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00040709 81490 PTDSS2 http://www.ncbi.nlm.nih.gov/gene/?term=81490 PSS2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040710 81490 PTDSS2 http://www.ncbi.nlm.nih.gov/gene/?term=81490 PSS2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040711 81502 HM13 http://www.ncbi.nlm.nih.gov/gene/?term=81502 "H13, IMP1, IMPAS, IMPAS-1, MSTP086, PSENL3, PSL3, SPP, SPPL1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040712 81502 HM13 http://www.ncbi.nlm.nih.gov/gene/?term=81502 "H13, IMP1, IMPAS, IMPAS-1, MSTP086, PSENL3, PSL3, SPP, SPPL1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040713 81565 NDEL1 http://www.ncbi.nlm.nih.gov/gene/?term=81565 "EOPA, MITAP1, NDE1L1, NDE2, NUDEL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040714 81565 NDEL1 http://www.ncbi.nlm.nih.gov/gene/?term=81565 "EOPA, MITAP1, NDE1L1, NDE2, NUDEL" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040715 81603 TRIM8 http://www.ncbi.nlm.nih.gov/gene/?term=81603 "GERP, RNF27" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040716 81603 TRIM8 http://www.ncbi.nlm.nih.gov/gene/?term=81603 "GERP, RNF27" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040717 81605 URM1 http://www.ncbi.nlm.nih.gov/gene/?term=81605 C9orf74 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040718 81605 URM1 http://www.ncbi.nlm.nih.gov/gene/?term=81605 C9orf74 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040719 81606 LBH http://www.ncbi.nlm.nih.gov/gene/?term=81606 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040720 81606 LBH http://www.ncbi.nlm.nih.gov/gene/?term=81606 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040721 81607 NECTIN4 http://www.ncbi.nlm.nih.gov/gene/?term=81607 "EDSS1, LNIR, PRR4, PVRL4, nectin-4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040722 81607 NECTIN4 http://www.ncbi.nlm.nih.gov/gene/?term=81607 "EDSS1, LNIR, PRR4, PVRL4, nectin-4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040723 81608 FIP1L1 http://www.ncbi.nlm.nih.gov/gene/?term=81608 "FIP1, Rhe, hFip1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040724 81608 FIP1L1 http://www.ncbi.nlm.nih.gov/gene/?term=81608 "FIP1, Rhe, hFip1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040725 81609 SNX27 http://www.ncbi.nlm.nih.gov/gene/?term=81609 "MRT1, MY014" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040726 81609 SNX27 http://www.ncbi.nlm.nih.gov/gene/?term=81609 "MRT1, MY014" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040727 81619 TSPAN14 http://www.ncbi.nlm.nih.gov/gene/?term=81619 "DC-TM4F2, TM4SF14" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040728 81619 TSPAN14 http://www.ncbi.nlm.nih.gov/gene/?term=81619 "DC-TM4F2, TM4SF14" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040729 81688 C6orf62 http://www.ncbi.nlm.nih.gov/gene/?term=81688 "Nbla00237, XTP12, dJ30M3.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040730 81693 AMN http://www.ncbi.nlm.nih.gov/gene/?term=81693 "PRO1028, amnionless" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040731 81693 AMN http://www.ncbi.nlm.nih.gov/gene/?term=81693 "PRO1028, amnionless" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040732 817 CAMK2D http://www.ncbi.nlm.nih.gov/gene/?term=817 CAMKD mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040733 817 CAMK2D http://www.ncbi.nlm.nih.gov/gene/?term=817 CAMKD mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040734 81790 RNF170 http://www.ncbi.nlm.nih.gov/gene/?term=81790 "ADSA, SNAX1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040735 81790 RNF170 http://www.ncbi.nlm.nih.gov/gene/?term=81790 "ADSA, SNAX1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040736 81846 SBF2 http://www.ncbi.nlm.nih.gov/gene/?term=81846 "CMT4B2, DENND7B, MTMR13" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040737 8202 NCOA3 http://www.ncbi.nlm.nih.gov/gene/?term=8202 "ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040738 8202 NCOA3 http://www.ncbi.nlm.nih.gov/gene/?term=8202 "ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040739 8218 CLTCL1 http://www.ncbi.nlm.nih.gov/gene/?term=8218 "CHC22, CLH22, CLTCL, CLTD" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040740 8218 CLTCL1 http://www.ncbi.nlm.nih.gov/gene/?term=8218 "CHC22, CLH22, CLTCL, CLTD" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040741 8224 SYN3 http://www.ncbi.nlm.nih.gov/gene/?term=8224 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040742 8224 SYN3 http://www.ncbi.nlm.nih.gov/gene/?term=8224 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040743 8289 ARID1A http://www.ncbi.nlm.nih.gov/gene/?term=8289 "B120, BAF250, BAF250a, BM029, C1orf4, CSS2, ELD, MRD14, OSA1, P270, SMARCF1, hELD, hOSA1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040744 8291 DYSF http://www.ncbi.nlm.nih.gov/gene/?term=8291 "FER1L1, LGMD2B, MMD1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040745 8291 DYSF http://www.ncbi.nlm.nih.gov/gene/?term=8291 "FER1L1, LGMD2B, MMD1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040746 8295 TRRAP http://www.ncbi.nlm.nih.gov/gene/?term=8295 "PAF350/400, PAF400, STAF40, TR-AP, Tra1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040747 8295 TRRAP http://www.ncbi.nlm.nih.gov/gene/?term=8295 "PAF350/400, PAF400, STAF40, TR-AP, Tra1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040748 8301 PICALM http://www.ncbi.nlm.nih.gov/gene/?term=8301 "CALM, CLTH, LAP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040749 8301 PICALM http://www.ncbi.nlm.nih.gov/gene/?term=8301 "CALM, CLTH, LAP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040750 831 CAST http://www.ncbi.nlm.nih.gov/gene/?term=831 "BS-17, PLACK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040751 831 CAST http://www.ncbi.nlm.nih.gov/gene/?term=831 "BS-17, PLACK" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040752 8312 AXIN1 http://www.ncbi.nlm.nih.gov/gene/?term=8312 "AXIN, PPP1R49" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040753 8312 AXIN1 http://www.ncbi.nlm.nih.gov/gene/?term=8312 "AXIN, PPP1R49" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040754 8313 AXIN2 http://www.ncbi.nlm.nih.gov/gene/?term=8313 "AXIL, ODCRCS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040755 8313 AXIN2 http://www.ncbi.nlm.nih.gov/gene/?term=8313 "AXIL, ODCRCS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040756 83439 TCF7L1 http://www.ncbi.nlm.nih.gov/gene/?term=83439 "TCF-3, TCF3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040757 83439 TCF7L1 http://www.ncbi.nlm.nih.gov/gene/?term=83439 "TCF-3, TCF3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040758 83478 ARHGAP24 http://www.ncbi.nlm.nih.gov/gene/?term=83478 "FILGAP, RC-GAP72, RCGAP72, p73, p73RhoGAP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040759 83478 ARHGAP24 http://www.ncbi.nlm.nih.gov/gene/?term=83478 "FILGAP, RC-GAP72, RCGAP72, p73, p73RhoGAP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040760 83479 DDX59 http://www.ncbi.nlm.nih.gov/gene/?term=83479 "OFD5, ZNHIT5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040761 83479 DDX59 http://www.ncbi.nlm.nih.gov/gene/?term=83479 "OFD5, ZNHIT5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040762 83548 COG3 http://www.ncbi.nlm.nih.gov/gene/?term=83548 SEC34 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040763 83605 CCM2 http://www.ncbi.nlm.nih.gov/gene/?term=83605 "C7orf22, OSM, PP10187" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040764 83605 CCM2 http://www.ncbi.nlm.nih.gov/gene/?term=83605 "C7orf22, OSM, PP10187" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040765 83636 C19orf12 http://www.ncbi.nlm.nih.gov/gene/?term=83636 "MPAN, NBIA3, NBIA4, SPG43" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040766 83636 C19orf12 http://www.ncbi.nlm.nih.gov/gene/?term=83636 "MPAN, NBIA3, NBIA4, SPG43" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040767 83641 FAM107B http://www.ncbi.nlm.nih.gov/gene/?term=83641 "C10orf45, HITS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040768 83641 FAM107B http://www.ncbi.nlm.nih.gov/gene/?term=83641 "C10orf45, HITS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040769 83642 SELENOO http://www.ncbi.nlm.nih.gov/gene/?term=83642 SELO mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040770 83642 SELENOO http://www.ncbi.nlm.nih.gov/gene/?term=83642 SELO mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040771 83648 FAM167A http://www.ncbi.nlm.nih.gov/gene/?term=83648 "C8orf13, D8S265" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040772 83648 FAM167A http://www.ncbi.nlm.nih.gov/gene/?term=83648 "C8orf13, D8S265" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040773 83660 TLN2 http://www.ncbi.nlm.nih.gov/gene/?term=83660 ILWEQ mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040774 83660 TLN2 http://www.ncbi.nlm.nih.gov/gene/?term=83660 ILWEQ mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040775 83667 SESN2 http://www.ncbi.nlm.nih.gov/gene/?term=83667 "HI95, SES2, SEST2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040776 83692 CD99L2 http://www.ncbi.nlm.nih.gov/gene/?term=83692 "CD99B, MIC2L1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040777 83692 CD99L2 http://www.ncbi.nlm.nih.gov/gene/?term=83692 "CD99B, MIC2L1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040778 83696 TRAPPC9 http://www.ncbi.nlm.nih.gov/gene/?term=83696 "IBP, IKBKBBP, MRT13, NIBP, T1, TRS120" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040779 83696 TRAPPC9 http://www.ncbi.nlm.nih.gov/gene/?term=83696 "IBP, IKBKBBP, MRT13, NIBP, T1, TRS120" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040780 83716 CRISPLD2 http://www.ncbi.nlm.nih.gov/gene/?term=83716 "CRISP11, LCRISP2, LGL1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040781 83716 CRISPLD2 http://www.ncbi.nlm.nih.gov/gene/?term=83716 "CRISP11, LCRISP2, LGL1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040782 83758 RBP5 http://www.ncbi.nlm.nih.gov/gene/?term=83758 "CRBP-III, CRBP3, CRBPIII, HRBPiso" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040783 83758 RBP5 http://www.ncbi.nlm.nih.gov/gene/?term=83758 "CRBP-III, CRBP3, CRBPIII, HRBPiso" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040784 83759 RBM4B http://www.ncbi.nlm.nih.gov/gene/?term=83759 "RBM30, RBM4L, ZCCHC15, ZCCHC21B, ZCRB3B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040785 83759 RBM4B http://www.ncbi.nlm.nih.gov/gene/?term=83759 "RBM30, RBM4L, ZCCHC15, ZCCHC21B, ZCRB3B" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040786 83878 USHBP1 http://www.ncbi.nlm.nih.gov/gene/?term=83878 "AIEBP, MCC2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040787 83878 USHBP1 http://www.ncbi.nlm.nih.gov/gene/?term=83878 "AIEBP, MCC2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040788 83938 LRMDA http://www.ncbi.nlm.nih.gov/gene/?term=83938 "C10orf11, CDA017" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040789 83938 LRMDA http://www.ncbi.nlm.nih.gov/gene/?term=83938 "C10orf11, CDA017" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040790 8394 PIP5K1A http://www.ncbi.nlm.nih.gov/gene/?term=8394 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040791 8394 PIP5K1A http://www.ncbi.nlm.nih.gov/gene/?term=8394 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040792 8395 PIP5K1B http://www.ncbi.nlm.nih.gov/gene/?term=8395 "MSS4, STM7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040793 8395 PIP5K1B http://www.ncbi.nlm.nih.gov/gene/?term=8395 "MSS4, STM7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040794 83989 FAM172A http://www.ncbi.nlm.nih.gov/gene/?term=83989 C5orf21 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040795 83992 CTTNBP2 http://www.ncbi.nlm.nih.gov/gene/?term=83992 "C7orf8, CORTBP2, Orf4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040796 84002 B3GNT5 http://www.ncbi.nlm.nih.gov/gene/?term=84002 "B3GN-T5, beta3Gn-T5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040797 84033 OBSCN http://www.ncbi.nlm.nih.gov/gene/?term=84033 "ARHGEF30, UNC89" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040798 84056 KATNAL1 http://www.ncbi.nlm.nih.gov/gene/?term=84056 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040799 84059 ADGRV1 http://www.ncbi.nlm.nih.gov/gene/?term=84059 "FEB4, GPR98, MASS1, USH2B, USH2C, VLGR1, VLGR1b" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040800 84062 DTNBP1 http://www.ncbi.nlm.nih.gov/gene/?term=84062 "BLOC1S8, DBND, HPS7, My031, SDY" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040801 84064 HDHD2 http://www.ncbi.nlm.nih.gov/gene/?term=84064 "3110052N05Rik, HEL-S-301" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040802 84064 HDHD2 http://www.ncbi.nlm.nih.gov/gene/?term=84064 "3110052N05Rik, HEL-S-301" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040803 84081 NSRP1 http://www.ncbi.nlm.nih.gov/gene/?term=84081 "CCDC55, HSPC095, NSrp70" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040804 841 CASP8 http://www.ncbi.nlm.nih.gov/gene/?term=841 "ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040805 841 CASP8 http://www.ncbi.nlm.nih.gov/gene/?term=841 "ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040806 8412 BCAR3 http://www.ncbi.nlm.nih.gov/gene/?term=8412 "NSP2, SH2D3B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040807 8412 BCAR3 http://www.ncbi.nlm.nih.gov/gene/?term=8412 "NSP2, SH2D3B" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040808 84138 SLC7A6OS http://www.ncbi.nlm.nih.gov/gene/?term=84138 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040809 84138 SLC7A6OS http://www.ncbi.nlm.nih.gov/gene/?term=84138 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040810 84153 RNASEH2C http://www.ncbi.nlm.nih.gov/gene/?term=84153 "AGS3, AYP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040811 84153 RNASEH2C http://www.ncbi.nlm.nih.gov/gene/?term=84153 "AGS3, AYP1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040812 84168 ANTXR1 http://www.ncbi.nlm.nih.gov/gene/?term=84168 "ATR, GAPO, TEM8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040813 84168 ANTXR1 http://www.ncbi.nlm.nih.gov/gene/?term=84168 "ATR, GAPO, TEM8" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040814 84186 ZCCHC7 http://www.ncbi.nlm.nih.gov/gene/?term=84186 "AIR1, HSPC086" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040815 84186 ZCCHC7 http://www.ncbi.nlm.nih.gov/gene/?term=84186 "AIR1, HSPC086" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040816 84187 TMEM164 http://www.ncbi.nlm.nih.gov/gene/?term=84187 bB360B22.3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040817 84187 TMEM164 http://www.ncbi.nlm.nih.gov/gene/?term=84187 bB360B22.3 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040818 84251 SGIP1 http://www.ncbi.nlm.nih.gov/gene/?term=84251 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040819 84251 SGIP1 http://www.ncbi.nlm.nih.gov/gene/?term=84251 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040820 84253 GARNL3 http://www.ncbi.nlm.nih.gov/gene/?term=84253 bA356B19.1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040821 84253 GARNL3 http://www.ncbi.nlm.nih.gov/gene/?term=84253 bA356B19.1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040822 84254 CAMKK1 http://www.ncbi.nlm.nih.gov/gene/?term=84254 CAMKKA mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040823 84254 CAMKK1 http://www.ncbi.nlm.nih.gov/gene/?term=84254 CAMKKA mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040824 84255 SLC37A3 http://www.ncbi.nlm.nih.gov/gene/?term=84255 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040825 84260 TCHP http://www.ncbi.nlm.nih.gov/gene/?term=84260 TpMs mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040826 84268 RPAIN http://www.ncbi.nlm.nih.gov/gene/?term=84268 "HRIP, RIP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040827 84275 SLC25A33 http://www.ncbi.nlm.nih.gov/gene/?term=84275 "BMSC-MCP, PNC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040828 8428 STK24 http://www.ncbi.nlm.nih.gov/gene/?term=8428 "HEL-S-95, MST3, MST3B, STE20, STK3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040829 8428 STK24 http://www.ncbi.nlm.nih.gov/gene/?term=8428 "HEL-S-95, MST3, MST3B, STE20, STK3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040830 84300 UQCC2 http://www.ncbi.nlm.nih.gov/gene/?term=84300 "C6orf125, C6orf126, Cbp6, M19, MNF1, bA6B20.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040831 84300 UQCC2 http://www.ncbi.nlm.nih.gov/gene/?term=84300 "C6orf125, C6orf126, Cbp6, M19, MNF1, bA6B20.2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040832 84316 NAA38 http://www.ncbi.nlm.nih.gov/gene/?term=84316 "LSMD1, PFAAP2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040833 84319 CMSS1 http://www.ncbi.nlm.nih.gov/gene/?term=84319 C3orf26 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040834 84320 ACBD6 http://www.ncbi.nlm.nih.gov/gene/?term=84320 MGC2404 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040835 84329 HVCN1 http://www.ncbi.nlm.nih.gov/gene/?term=84329 "HV1, VSOP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040836 84329 HVCN1 http://www.ncbi.nlm.nih.gov/gene/?term=84329 "HV1, VSOP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040837 84333 PCGF5 http://www.ncbi.nlm.nih.gov/gene/?term=84333 RNF159 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040838 84335 AKT1S1 http://www.ncbi.nlm.nih.gov/gene/?term=84335 "Lobe, PRAS40" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040839 84335 AKT1S1 http://www.ncbi.nlm.nih.gov/gene/?term=84335 "Lobe, PRAS40" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040840 8434 RECK http://www.ncbi.nlm.nih.gov/gene/?term=8434 ST15 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00040841 84340 GFM2 http://www.ncbi.nlm.nih.gov/gene/?term=84340 "EF-G2mt, EFG2, MRRF2, MST027, MSTP027, RRF2, RRF2mt, hEFG2, mEF-G 2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040842 84376 HOOK3 http://www.ncbi.nlm.nih.gov/gene/?term=84376 HK3 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040843 84418 CYSTM1 http://www.ncbi.nlm.nih.gov/gene/?term=84418 "C5orf32, ORF1-FL49" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040844 84418 CYSTM1 http://www.ncbi.nlm.nih.gov/gene/?term=84418 "C5orf32, ORF1-FL49" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040845 84435 ADGRA1 http://www.ncbi.nlm.nih.gov/gene/?term=84435 GPR123 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040846 84435 ADGRA1 http://www.ncbi.nlm.nih.gov/gene/?term=84435 GPR123 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040847 84441 MAML2 http://www.ncbi.nlm.nih.gov/gene/?term=84441 "MAM-3, MAM2, MAM3, MLL-MAML2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040848 84441 MAML2 http://www.ncbi.nlm.nih.gov/gene/?term=84441 "MAM-3, MAM2, MAM3, MLL-MAML2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040849 84449 ZNF333 http://www.ncbi.nlm.nih.gov/gene/?term=84449 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040850 84455 EFCAB7 http://www.ncbi.nlm.nih.gov/gene/?term=84455 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040851 84498 FAM120B http://www.ncbi.nlm.nih.gov/gene/?term=84498 "CCPG, KIAA1838, PGCC1, dJ894D12.1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040852 84498 FAM120B http://www.ncbi.nlm.nih.gov/gene/?term=84498 "CCPG, KIAA1838, PGCC1, dJ894D12.1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040853 8451 CUL4A http://www.ncbi.nlm.nih.gov/gene/?term=8451 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040854 8451 CUL4A http://www.ncbi.nlm.nih.gov/gene/?term=8451 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040855 8452 CUL3 http://www.ncbi.nlm.nih.gov/gene/?term=8452 "CUL-3, PHA2E" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040856 84524 ZC3H8 http://www.ncbi.nlm.nih.gov/gene/?term=84524 "Fliz1, ZC3HDC8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040857 84530 SRRM4 http://www.ncbi.nlm.nih.gov/gene/?term=84530 "KIAA1853, MU-MB-2.76, nSR100" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040858 84530 SRRM4 http://www.ncbi.nlm.nih.gov/gene/?term=84530 "KIAA1853, MU-MB-2.76, nSR100" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040859 8458 TTF2 http://www.ncbi.nlm.nih.gov/gene/?term=8458 "HuF2, ZGRF6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040860 8458 TTF2 http://www.ncbi.nlm.nih.gov/gene/?term=8458 "HuF2, ZGRF6" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040861 84623 KIRREL3 http://www.ncbi.nlm.nih.gov/gene/?term=84623 "KIRRE, MRD4, NEPH2, PRO4502" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040862 84623 KIRREL3 http://www.ncbi.nlm.nih.gov/gene/?term=84623 "KIRRE, MRD4, NEPH2, PRO4502" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040863 84650 EBPL http://www.ncbi.nlm.nih.gov/gene/?term=84650 EBRP mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040864 84650 EBPL http://www.ncbi.nlm.nih.gov/gene/?term=84650 EBRP mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040865 84656 GLYR1 http://www.ncbi.nlm.nih.gov/gene/?term=84656 "BM045, HIBDL, N-PAC, NP60" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040866 84656 GLYR1 http://www.ncbi.nlm.nih.gov/gene/?term=84656 "BM045, HIBDL, N-PAC, NP60" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040867 84668 FAM126A http://www.ncbi.nlm.nih.gov/gene/?term=84668 "DRCTNNB1A, HCC, HLD5, HYCC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040868 84668 FAM126A http://www.ncbi.nlm.nih.gov/gene/?term=84668 "DRCTNNB1A, HCC, HLD5, HYCC1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040869 84695 LOXL3 http://www.ncbi.nlm.nih.gov/gene/?term=84695 LOXL mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040870 84695 LOXL3 http://www.ncbi.nlm.nih.gov/gene/?term=84695 LOXL mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040871 8470 SORBS2 http://www.ncbi.nlm.nih.gov/gene/?term=8470 "ARGBP2, PRO0618" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040872 8470 SORBS2 http://www.ncbi.nlm.nih.gov/gene/?term=8470 "ARGBP2, PRO0618" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040873 84859 LRCH3 http://www.ncbi.nlm.nih.gov/gene/?term=84859 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040874 84869 CBR4 http://www.ncbi.nlm.nih.gov/gene/?term=84869 SDR45C1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040875 84869 CBR4 http://www.ncbi.nlm.nih.gov/gene/?term=84869 SDR45C1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040876 84893 FBXO18 http://www.ncbi.nlm.nih.gov/gene/?term=84893 "FBH1, Fbx18, hFBH1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040877 84893 FBXO18 http://www.ncbi.nlm.nih.gov/gene/?term=84893 "FBH1, Fbx18, hFBH1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040878 84898 PLXDC2 http://www.ncbi.nlm.nih.gov/gene/?term=84898 TEM7R mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040879 84909 C9orf3 http://www.ncbi.nlm.nih.gov/gene/?term=84909 "AOPEP, AP-O, APO, C90RF3, ONPEP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040880 84909 C9orf3 http://www.ncbi.nlm.nih.gov/gene/?term=84909 "AOPEP, AP-O, APO, C90RF3, ONPEP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040881 8491 MAP4K3 http://www.ncbi.nlm.nih.gov/gene/?term=8491 "GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040882 8491 MAP4K3 http://www.ncbi.nlm.nih.gov/gene/?term=8491 "GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040883 84910 TMEM87B http://www.ncbi.nlm.nih.gov/gene/?term=84910 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040884 84910 TMEM87B http://www.ncbi.nlm.nih.gov/gene/?term=84910 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040885 84918 LRP11 http://www.ncbi.nlm.nih.gov/gene/?term=84918 "MANSC3, bA350J20.3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040886 84918 LRP11 http://www.ncbi.nlm.nih.gov/gene/?term=84918 "MANSC3, bA350J20.3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040887 84942 WDR73 http://www.ncbi.nlm.nih.gov/gene/?term=84942 "GAMOS, HSPC264" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040888 84951 TNS4 http://www.ncbi.nlm.nih.gov/gene/?term=84951 "CTEN, PP14434" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040889 84951 TNS4 http://www.ncbi.nlm.nih.gov/gene/?term=84951 "CTEN, PP14434" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040890 84961 FBXL20 http://www.ncbi.nlm.nih.gov/gene/?term=84961 "Fbl2, Fbl20" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040891 84961 FBXL20 http://www.ncbi.nlm.nih.gov/gene/?term=84961 "Fbl2, Fbl20" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040892 84966 IGSF21 http://www.ncbi.nlm.nih.gov/gene/?term=84966 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040893 84966 IGSF21 http://www.ncbi.nlm.nih.gov/gene/?term=84966 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040894 8500 PPFIA1 http://www.ncbi.nlm.nih.gov/gene/?term=8500 "LIP.1, LIP1, LIPRIN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040895 8500 PPFIA1 http://www.ncbi.nlm.nih.gov/gene/?term=8500 "LIP.1, LIP1, LIPRIN" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040896 8527 DGKD http://www.ncbi.nlm.nih.gov/gene/?term=8527 "DGKdelta, dgkd-2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040897 8527 DGKD http://www.ncbi.nlm.nih.gov/gene/?term=8527 "DGKdelta, dgkd-2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040898 85301 COL27A1 http://www.ncbi.nlm.nih.gov/gene/?term=85301 STLS mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040899 85301 COL27A1 http://www.ncbi.nlm.nih.gov/gene/?term=85301 STLS mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040900 85446 ZFHX2 http://www.ncbi.nlm.nih.gov/gene/?term=85446 "ZFH-5, ZNF409" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040901 85446 ZFHX2 http://www.ncbi.nlm.nih.gov/gene/?term=85446 "ZFH-5, ZNF409" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040902 85456 TNKS1BP1 http://www.ncbi.nlm.nih.gov/gene/?term=85456 TAB182 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040903 85456 TNKS1BP1 http://www.ncbi.nlm.nih.gov/gene/?term=85456 TAB182 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040904 8546 AP3B1 http://www.ncbi.nlm.nih.gov/gene/?term=8546 "ADTB3, ADTB3A, HPS, HPS2, PE" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040905 8546 AP3B1 http://www.ncbi.nlm.nih.gov/gene/?term=8546 "ADTB3, ADTB3A, HPS, HPS2, PE" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040906 85461 TANC1 http://www.ncbi.nlm.nih.gov/gene/?term=85461 "ROLSB, TANC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040907 85461 TANC1 http://www.ncbi.nlm.nih.gov/gene/?term=85461 "ROLSB, TANC" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040908 85464 SSH2 http://www.ncbi.nlm.nih.gov/gene/?term=85464 "SSH-2, SSH-2L" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040909 85464 SSH2 http://www.ncbi.nlm.nih.gov/gene/?term=85464 "SSH-2, SSH-2L" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040910 85476 GFM1 http://www.ncbi.nlm.nih.gov/gene/?term=85476 "COXPD1, EFG, EFG1, EFGM, EGF1, GFM, hEFG1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040911 85476 GFM1 http://www.ncbi.nlm.nih.gov/gene/?term=85476 "COXPD1, EFG, EFG1, EFGM, EGF1, GFM, hEFG1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040912 8554 PIAS1 http://www.ncbi.nlm.nih.gov/gene/?term=8554 "DDXBP1, GBP, GU/RH-II, ZMIZ3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040913 8554 PIAS1 http://www.ncbi.nlm.nih.gov/gene/?term=8554 "DDXBP1, GBP, GU/RH-II, ZMIZ3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040914 8562 DENR http://www.ncbi.nlm.nih.gov/gene/?term=8562 "DRP, DRP1, SMAP-3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040915 8569 MKNK1 http://www.ncbi.nlm.nih.gov/gene/?term=8569 MNK1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040916 8573 CASK http://www.ncbi.nlm.nih.gov/gene/?term=8573 "CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8, hCASK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040917 8573 CASK http://www.ncbi.nlm.nih.gov/gene/?term=8573 "CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8, hCASK" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040918 861 RUNX1 http://www.ncbi.nlm.nih.gov/gene/?term=861 "AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040919 861 RUNX1 http://www.ncbi.nlm.nih.gov/gene/?term=861 "AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040920 8611 PLPP1 http://www.ncbi.nlm.nih.gov/gene/?term=8611 "LLP1a, LPP1, PAP-2a, PAP2, PPAP2A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040921 8611 PLPP1 http://www.ncbi.nlm.nih.gov/gene/?term=8611 "LLP1a, LPP1, PAP-2a, PAP2, PPAP2A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040922 8614 STC2 http://www.ncbi.nlm.nih.gov/gene/?term=8614 "STC-2, STCRP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040923 8614 STC2 http://www.ncbi.nlm.nih.gov/gene/?term=8614 "STC-2, STCRP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040924 8618 CADPS http://www.ncbi.nlm.nih.gov/gene/?term=8618 "CADPS1, CAPS, CAPS1, UNC-31" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040925 8618 CADPS http://www.ncbi.nlm.nih.gov/gene/?term=8618 "CADPS1, CAPS, CAPS1, UNC-31" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040926 862 RUNX1T1 http://www.ncbi.nlm.nih.gov/gene/?term=862 "AML1-MTG8, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040927 8621 CDK13 http://www.ncbi.nlm.nih.gov/gene/?term=8621 "CDC2L, CDC2L5, CHDFIDD, CHED, hCDK13" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040928 8621 CDK13 http://www.ncbi.nlm.nih.gov/gene/?term=8621 "CDC2L, CDC2L5, CHDFIDD, CHED, hCDK13" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040929 8622 PDE8B http://www.ncbi.nlm.nih.gov/gene/?term=8622 "ADSD, PPNAD3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040930 8648 NCOA1 http://www.ncbi.nlm.nih.gov/gene/?term=8648 "F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040931 8658 TNKS http://www.ncbi.nlm.nih.gov/gene/?term=8658 "ARTD5, PARP-5a, PARP5A, PARPL, TIN1, TINF11, pART5, TNKS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040932 8658 TNKS http://www.ncbi.nlm.nih.gov/gene/?term=8658 "ARTD5, PARP-5a, PARP5A, PARPL, TIN1, TINF11, pART5, TNKS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040933 8660 IRS2 http://www.ncbi.nlm.nih.gov/gene/?term=8660 IRS-2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040934 8665 EIF3F http://www.ncbi.nlm.nih.gov/gene/?term=8665 "EIF3S5, eIF3-p47" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040935 8672 EIF4G3 http://www.ncbi.nlm.nih.gov/gene/?term=8672 "eIF-4G 3, eIF4G 3, eIF4GII" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040936 8672 EIF4G3 http://www.ncbi.nlm.nih.gov/gene/?term=8672 "eIF-4G 3, eIF4G 3, eIF4GII" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040937 868 CBLB http://www.ncbi.nlm.nih.gov/gene/?term=868 "Cbl-b, Nbla00127, RNF56" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040938 868 CBLB http://www.ncbi.nlm.nih.gov/gene/?term=868 "Cbl-b, Nbla00127, RNF56" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040939 8725 URI1 http://www.ncbi.nlm.nih.gov/gene/?term=8725 "C19orf2, NNX3, PPP1R19, RMP, URI" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040940 8743 TNFSF10 http://www.ncbi.nlm.nih.gov/gene/?term=8743 "APO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040941 8743 TNFSF10 http://www.ncbi.nlm.nih.gov/gene/?term=8743 "APO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040942 8745 ADAM23 http://www.ncbi.nlm.nih.gov/gene/?term=8745 "MDC-3, MDC3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040943 8763 CD164 http://www.ncbi.nlm.nih.gov/gene/?term=8763 "DFNA66, MGC-24, MGC-24v, MUC-24, endolyn" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040944 8763 CD164 http://www.ncbi.nlm.nih.gov/gene/?term=8763 "DFNA66, MGC-24, MGC-24v, MUC-24, endolyn" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040945 8764 TNFRSF14 http://www.ncbi.nlm.nih.gov/gene/?term=8764 "ATAR, CD270, HVEA, HVEM, LIGHTR, TR2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040946 8764 TNFRSF14 http://www.ncbi.nlm.nih.gov/gene/?term=8764 "ATAR, CD270, HVEA, HVEM, LIGHTR, TR2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040947 8766 RAB11A http://www.ncbi.nlm.nih.gov/gene/?term=8766 YL8 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040948 8766 RAB11A http://www.ncbi.nlm.nih.gov/gene/?term=8766 YL8 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040949 8773 SNAP23 http://www.ncbi.nlm.nih.gov/gene/?term=8773 "HsT17016, SNAP-23A, SNAP23B, SNAP23" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040950 8801 SUCLG2 http://www.ncbi.nlm.nih.gov/gene/?term=8801 "G-SCS, GBETA, GTPSCS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040951 8813 DPM1 http://www.ncbi.nlm.nih.gov/gene/?term=8813 "CDGIE, MPDS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040952 8813 DPM1 http://www.ncbi.nlm.nih.gov/gene/?term=8813 "CDGIE, MPDS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040953 8828 NRP2 http://www.ncbi.nlm.nih.gov/gene/?term=8828 "NP2, NPN2, PRO2714, VEGF165R2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040954 8853 ASAP2 http://www.ncbi.nlm.nih.gov/gene/?term=8853 "AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040955 8869 ST3GAL5 http://www.ncbi.nlm.nih.gov/gene/?term=8869 "SATI, SIAT9, SIATGM3S, SPDRS, ST3Gal V, ST3GalV" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040956 8869 ST3GAL5 http://www.ncbi.nlm.nih.gov/gene/?term=8869 "SATI, SIAT9, SIATGM3S, SPDRS, ST3Gal V, ST3GalV" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040957 8878 SQSTM1 http://www.ncbi.nlm.nih.gov/gene/?term=8878 "A170, DMRV, FTDALS3, NADGP, OSIL, PDB3, ZIP3, p60, p62, p62B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040958 8878 SQSTM1 http://www.ncbi.nlm.nih.gov/gene/?term=8878 "A170, DMRV, FTDALS3, NADGP, OSIL, PDB3, ZIP3, p60, p62, p62B" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040959 8883 NAE1 http://www.ncbi.nlm.nih.gov/gene/?term=8883 "A-116A10.1, APPBP1, HPP1, ula-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040960 8883 NAE1 http://www.ncbi.nlm.nih.gov/gene/?term=8883 "A-116A10.1, APPBP1, HPP1, ula-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040961 8887 TAX1BP1 http://www.ncbi.nlm.nih.gov/gene/?term=8887 "CALCOCO3, T6BP, TXBP151" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040962 8887 TAX1BP1 http://www.ncbi.nlm.nih.gov/gene/?term=8887 "CALCOCO3, T6BP, TXBP151" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040963 8925 HERC1 http://www.ncbi.nlm.nih.gov/gene/?term=8925 "MDFPMR, p532, p619" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040964 8925 HERC1 http://www.ncbi.nlm.nih.gov/gene/?term=8925 "MDFPMR, p532, p619" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040965 8932 MBD2 http://www.ncbi.nlm.nih.gov/gene/?term=8932 "DMTase, NY-CO-41" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040966 8935 SKAP2 http://www.ncbi.nlm.nih.gov/gene/?term=8935 "PRAP, RA70, SAPS, SCAP2, SKAP-HOM, SKAP55R" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040967 8942 KYNU http://www.ncbi.nlm.nih.gov/gene/?term=8942 KYNUU mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040968 8976 WASL http://www.ncbi.nlm.nih.gov/gene/?term=8976 "N-WASP, NWASP, WASPB" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040969 8976 WASL http://www.ncbi.nlm.nih.gov/gene/?term=8976 "N-WASP, NWASP, WASPB" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040970 89796 NAV1 http://www.ncbi.nlm.nih.gov/gene/?term=89796 "POMFIL3, STEERIN1, UNC53H1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040971 89797 NAV2 http://www.ncbi.nlm.nih.gov/gene/?term=89797 "HELAD1, POMFIL2, RAINB1, STEERIN2, UNC53H2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040972 89797 NAV2 http://www.ncbi.nlm.nih.gov/gene/?term=89797 "HELAD1, POMFIL2, RAINB1, STEERIN2, UNC53H2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040973 8992 ATP6V0E1 http://www.ncbi.nlm.nih.gov/gene/?term=8992 "ATP6H, ATP6V0E, M9.2, Vma21, Vma21p" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040974 8992 ATP6V0E1 http://www.ncbi.nlm.nih.gov/gene/?term=8992 "ATP6H, ATP6V0E, M9.2, Vma21, Vma21p" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040975 89927 C16orf45 http://www.ncbi.nlm.nih.gov/gene/?term=89927 MINP mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040976 89927 C16orf45 http://www.ncbi.nlm.nih.gov/gene/?term=89927 MINP mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040977 8994 LIMD1 http://www.ncbi.nlm.nih.gov/gene/?term=8994 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040978 8994 LIMD1 http://www.ncbi.nlm.nih.gov/gene/?term=8994 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040979 9014 TAF1B http://www.ncbi.nlm.nih.gov/gene/?term=9014 "MGC:9349, RAF1B, RAFI63, SL1, TAFI63" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040980 90141 EFCAB11 http://www.ncbi.nlm.nih.gov/gene/?term=90141 C14orf143 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040981 90141 EFCAB11 http://www.ncbi.nlm.nih.gov/gene/?term=90141 C14orf143 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040982 90203 SNX21 http://www.ncbi.nlm.nih.gov/gene/?term=90203 "C20orf161, PP3993, SNX-L, dJ337O18.4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040983 90203 SNX21 http://www.ncbi.nlm.nih.gov/gene/?term=90203 "C20orf161, PP3993, SNX-L, dJ337O18.4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040984 90268 OTULIN http://www.ncbi.nlm.nih.gov/gene/?term=90268 "AIPDS, FAM105B, GUM" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040985 9031 BAZ1B http://www.ncbi.nlm.nih.gov/gene/?term=9031 "WBSCR10, WBSCR9, WSTF" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040986 90355 C5orf30 http://www.ncbi.nlm.nih.gov/gene/?term=90355 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040987 90355 C5orf30 http://www.ncbi.nlm.nih.gov/gene/?term=90355 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040988 9039 UBA3 http://www.ncbi.nlm.nih.gov/gene/?term=9039 "NAE2, UBE1C, hUBA3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040989 9039 UBA3 http://www.ncbi.nlm.nih.gov/gene/?term=9039 "NAE2, UBE1C, hUBA3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040990 90427 BMF http://www.ncbi.nlm.nih.gov/gene/?term=90427 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040991 90427 BMF http://www.ncbi.nlm.nih.gov/gene/?term=90427 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040992 9044 BTAF1 http://www.ncbi.nlm.nih.gov/gene/?term=9044 "MOT1, TAF(II)170, TAF172, TAFII170" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040993 9044 BTAF1 http://www.ncbi.nlm.nih.gov/gene/?term=9044 "MOT1, TAF(II)170, TAF172, TAFII170" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00040994 9052 GPRC5A http://www.ncbi.nlm.nih.gov/gene/?term=9052 "GPCR5A, PEIG-1, RAI3, RAIG1, TIG1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040995 9057 SLC7A6 http://www.ncbi.nlm.nih.gov/gene/?term=9057 "LAT-2, LAT3, y+LAT-2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040996 9061 PAPSS1 http://www.ncbi.nlm.nih.gov/gene/?term=9061 "ATPSK1, PAPSS, SK1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040997 90627 STARD13 http://www.ncbi.nlm.nih.gov/gene/?term=90627 "ARHGAP37, DLC2, GT650, LINC00464" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040998 9063 PIAS2 http://www.ncbi.nlm.nih.gov/gene/?term=9063 "ARIP3, DIP, MIZ1, PIASX, SIZ2, ZMIZ4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00040999 90799 CEP95 http://www.ncbi.nlm.nih.gov/gene/?term=90799 CCDC45 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041000 90799 CEP95 http://www.ncbi.nlm.nih.gov/gene/?term=90799 CCDC45 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041001 91 ACVR1B http://www.ncbi.nlm.nih.gov/gene/?term=91 "ACTRIB, ACVRLK4, ALK4, SKR2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041002 91 ACVR1B http://www.ncbi.nlm.nih.gov/gene/?term=91 "ACTRIB, ACVRLK4, ALK4, SKR2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041003 9100 USP10 http://www.ncbi.nlm.nih.gov/gene/?term=9100 UBPO mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041004 9100 USP10 http://www.ncbi.nlm.nih.gov/gene/?term=9100 UBPO mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041005 9101 USP8 http://www.ncbi.nlm.nih.gov/gene/?term=9101 "HumORF8, SPG59, UBPY" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041006 9101 USP8 http://www.ncbi.nlm.nih.gov/gene/?term=9101 "HumORF8, SPG59, UBPY" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041007 91012 CERS5 http://www.ncbi.nlm.nih.gov/gene/?term=91012 "LASS5, Trh4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041008 91012 CERS5 http://www.ncbi.nlm.nih.gov/gene/?term=91012 "LASS5, Trh4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041009 9112 MTA1 http://www.ncbi.nlm.nih.gov/gene/?term=9112 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041010 9112 MTA1 http://www.ncbi.nlm.nih.gov/gene/?term=9112 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041011 9113 LATS1 http://www.ncbi.nlm.nih.gov/gene/?term=9113 "WARTS, wts" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041012 9113 LATS1 http://www.ncbi.nlm.nih.gov/gene/?term=9113 "WARTS, wts" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041013 9125 CNOT9 http://www.ncbi.nlm.nih.gov/gene/?term=9125 "CAF40, CT129, RCD-1, RCD1, RQCD1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041014 9129 PRPF3 http://www.ncbi.nlm.nih.gov/gene/?term=9129 "HPRP3, HPRP3P, PRP3, Prp3p, RP18, SNRNP90" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041015 9129 PRPF3 http://www.ncbi.nlm.nih.gov/gene/?term=9129 "HPRP3, HPRP3P, PRP3, Prp3p, RP18, SNRNP90" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041016 9131 AIFM1 http://www.ncbi.nlm.nih.gov/gene/?term=9131 "AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041017 9131 AIFM1 http://www.ncbi.nlm.nih.gov/gene/?term=9131 "AIF, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, NADMR, NAMSD, PDCD8" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041018 9135 RABEP1 http://www.ncbi.nlm.nih.gov/gene/?term=9135 "RAB5EP, RABPT5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041019 9135 RABEP1 http://www.ncbi.nlm.nih.gov/gene/?term=9135 "RAB5EP, RABPT5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041020 9138 ARHGEF1 http://www.ncbi.nlm.nih.gov/gene/?term=9138 "GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041021 9138 ARHGEF1 http://www.ncbi.nlm.nih.gov/gene/?term=9138 "GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041022 9147 NEMF http://www.ncbi.nlm.nih.gov/gene/?term=9147 "NY-CO-1, SDCCAG1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041023 9148 NEURL1 http://www.ncbi.nlm.nih.gov/gene/?term=9148 "NEUR1, NEURL, RNF67, bA416N2.1, neu, neu-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041024 9148 NEURL1 http://www.ncbi.nlm.nih.gov/gene/?term=9148 "NEUR1, NEURL, RNF67, bA416N2.1, neu, neu-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041025 91523 PCED1B http://www.ncbi.nlm.nih.gov/gene/?term=91523 FAM113B mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041026 91523 PCED1B http://www.ncbi.nlm.nih.gov/gene/?term=91523 FAM113B mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041027 9159 PCSK7 http://www.ncbi.nlm.nih.gov/gene/?term=9159 "LPC, PC7, PC8, SPC7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041028 9159 PCSK7 http://www.ncbi.nlm.nih.gov/gene/?term=9159 "LPC, PC7, PC8, SPC7" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041029 9169 SCAF11 http://www.ncbi.nlm.nih.gov/gene/?term=9169 "CASP11, SFRS2IP, SIP1, SRRP129, SRSF2IP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041030 9169 SCAF11 http://www.ncbi.nlm.nih.gov/gene/?term=9169 "CASP11, SFRS2IP, SIP1, SRRP129, SRSF2IP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041031 9173 IL1RL1 http://www.ncbi.nlm.nih.gov/gene/?term=9173 "DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041032 9173 IL1RL1 http://www.ncbi.nlm.nih.gov/gene/?term=9173 "DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041033 9180 OSMR http://www.ncbi.nlm.nih.gov/gene/?term=9180 "IL-31R-beta, IL-31RBB, PLCA1, OSMR" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041034 9180 OSMR http://www.ncbi.nlm.nih.gov/gene/?term=9180 "IL-31R-beta, IL-31RBB, PLCA1, OSMR" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041035 91833 WDR20 http://www.ncbi.nlm.nih.gov/gene/?term=91833 DMR mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041036 91833 WDR20 http://www.ncbi.nlm.nih.gov/gene/?term=91833 DMR mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041037 91949 COG7 http://www.ncbi.nlm.nih.gov/gene/?term=91949 CDG2E mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041038 91949 COG7 http://www.ncbi.nlm.nih.gov/gene/?term=91949 CDG2E mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041039 92 ACVR2A http://www.ncbi.nlm.nih.gov/gene/?term=92 "ACTRII, ACVR2" lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041040 9200 HACD1 http://www.ncbi.nlm.nih.gov/gene/?term=9200 "CAP, PTPLA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041041 9200 HACD1 http://www.ncbi.nlm.nih.gov/gene/?term=9200 "CAP, PTPLA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041042 92017 SNX29 http://www.ncbi.nlm.nih.gov/gene/?term=92017 "A-388D4.1, RUNDC2A" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041043 92017 SNX29 http://www.ncbi.nlm.nih.gov/gene/?term=92017 "A-388D4.1, RUNDC2A" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041044 9202 ZMYM4 http://www.ncbi.nlm.nih.gov/gene/?term=9202 "CDIR, MYM, ZNF198L3, ZNF262" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041045 9202 ZMYM4 http://www.ncbi.nlm.nih.gov/gene/?term=9202 "CDIR, MYM, ZNF198L3, ZNF262" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041046 9208 LRRFIP1 http://www.ncbi.nlm.nih.gov/gene/?term=9208 "FLAP-1, FLAP1, FLIIAP1, GCF-2, GCF2, HUFI-1, TRIP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041047 9208 LRRFIP1 http://www.ncbi.nlm.nih.gov/gene/?term=9208 "FLAP-1, FLAP1, FLIIAP1, GCF-2, GCF2, HUFI-1, TRIP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041048 92106 OXNAD1 http://www.ncbi.nlm.nih.gov/gene/?term=92106 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041049 92106 OXNAD1 http://www.ncbi.nlm.nih.gov/gene/?term=92106 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041050 9218 VAPA http://www.ncbi.nlm.nih.gov/gene/?term=9218 "VAP-33, VAP-A, VAP33, hVAP-33" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041051 9223 MAGI1 http://www.ncbi.nlm.nih.gov/gene/?term=9223 "AIP-3, AIP3, BAIAP1, BAP-1, BAP1, MAGI-1, Magi1d, TNRC19, WWP3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041052 9223 MAGI1 http://www.ncbi.nlm.nih.gov/gene/?term=9223 "AIP-3, AIP3, BAIAP1, BAP-1, BAP1, MAGI-1, Magi1d, TNRC19, WWP3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041053 92259 MRPS36 http://www.ncbi.nlm.nih.gov/gene/?term=92259 "DC47, MRP-S36" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041054 92259 MRPS36 http://www.ncbi.nlm.nih.gov/gene/?term=92259 "DC47, MRP-S36" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041055 9229 DLGAP1 http://www.ncbi.nlm.nih.gov/gene/?term=9229 "DAP-1, DAP-1-ALPHA, DAP-1-BETA, DAP1A, DLGAP1B, GKAP, SAPAP1, DLGAP1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041056 9231 DLG5 http://www.ncbi.nlm.nih.gov/gene/?term=9231 "LP-DLG, P-DLG5, PDLG" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041057 9231 DLG5 http://www.ncbi.nlm.nih.gov/gene/?term=9231 "LP-DLG, P-DLG5, PDLG" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041058 92399 MRRF http://www.ncbi.nlm.nih.gov/gene/?term=92399 "MRFF, MTRRF, RRF" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041059 9249 DHRS3 http://www.ncbi.nlm.nih.gov/gene/?term=9249 "DD83.1, RDH17, Rsdr1, SDR1, SDR16C1, retSDR1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041060 9249 DHRS3 http://www.ncbi.nlm.nih.gov/gene/?term=9249 "DD83.1, RDH17, Rsdr1, SDR1, SDR16C1, retSDR1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041061 9252 RPS6KA5 http://www.ncbi.nlm.nih.gov/gene/?term=9252 "MSK1, MSPK1, RLPK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041062 9252 RPS6KA5 http://www.ncbi.nlm.nih.gov/gene/?term=9252 "MSK1, MSPK1, RLPK" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041063 92521 SPECC1 http://www.ncbi.nlm.nih.gov/gene/?term=92521 "CYTSB, HCMOGT-1, HCMOGT1, NSP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041064 92521 SPECC1 http://www.ncbi.nlm.nih.gov/gene/?term=92521 "CYTSB, HCMOGT-1, HCMOGT1, NSP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041065 92591 ASB16 http://www.ncbi.nlm.nih.gov/gene/?term=92591 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041066 92591 ASB16 http://www.ncbi.nlm.nih.gov/gene/?term=92591 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041067 9261 MAPKAPK2 http://www.ncbi.nlm.nih.gov/gene/?term=9261 "MAPKAP-K2, MK-2, MK2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041068 9261 MAPKAPK2 http://www.ncbi.nlm.nih.gov/gene/?term=9261 "MAPKAP-K2, MK-2, MK2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041069 9263 STK17A http://www.ncbi.nlm.nih.gov/gene/?term=9263 DRAK1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041070 9265 CYTH3 http://www.ncbi.nlm.nih.gov/gene/?term=9265 "ARNO3, GRP1, PSCD3, cytohesin-3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041071 9265 CYTH3 http://www.ncbi.nlm.nih.gov/gene/?term=9265 "ARNO3, GRP1, PSCD3, cytohesin-3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041072 9267 CYTH1 http://www.ncbi.nlm.nih.gov/gene/?term=9267 "B2-1, CYTOHESIN-1, D17S811E, PSCD1, SEC7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041073 92675 DTD1 http://www.ncbi.nlm.nih.gov/gene/?term=92675 "C20orf88, DUE-B, DUEB, HARS2, pqn-68" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041074 92675 DTD1 http://www.ncbi.nlm.nih.gov/gene/?term=92675 "C20orf88, DUE-B, DUEB, HARS2, pqn-68" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041075 92737 DNER http://www.ncbi.nlm.nih.gov/gene/?term=92737 "UNQ26, bet" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041076 92737 DNER http://www.ncbi.nlm.nih.gov/gene/?term=92737 "UNQ26, bet" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041077 928 CD9 http://www.ncbi.nlm.nih.gov/gene/?term=928 "BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041078 928 CD9 http://www.ncbi.nlm.nih.gov/gene/?term=928 "BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041079 9282 MED14 http://www.ncbi.nlm.nih.gov/gene/?term=9282 "CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, RGR1, TRAP170" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041080 92822 ZNF276 http://www.ncbi.nlm.nih.gov/gene/?term=92822 "CENP-Z, CENPZ, ZADT, ZFP276, ZNF477" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041081 92822 ZNF276 http://www.ncbi.nlm.nih.gov/gene/?term=92822 "CENP-Z, CENPZ, ZADT, ZFP276, ZNF477" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041082 92906 HNRNPLL http://www.ncbi.nlm.nih.gov/gene/?term=92906 "HNRPLL, SRRF" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041083 92906 HNRNPLL http://www.ncbi.nlm.nih.gov/gene/?term=92906 "HNRPLL, SRRF" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041084 9310 ZNF235 http://www.ncbi.nlm.nih.gov/gene/?term=9310 "ANF270, HZF6, ZFP93, ZNF270" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041085 9310 ZNF235 http://www.ncbi.nlm.nih.gov/gene/?term=9310 "ANF270, HZF6, ZFP93, ZNF270" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041086 93145 OLFM2 http://www.ncbi.nlm.nih.gov/gene/?term=93145 "NOE2, NOELIN2, NOELIN2_V1, OlfC" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041087 93145 OLFM2 http://www.ncbi.nlm.nih.gov/gene/?term=93145 "NOE2, NOELIN2, NOELIN2_V1, OlfC" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041088 9320 TRIP12 http://www.ncbi.nlm.nih.gov/gene/?term=9320 "TRIP-12, ULF" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041089 9320 TRIP12 http://www.ncbi.nlm.nih.gov/gene/?term=9320 "TRIP-12, ULF" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041090 9334 B4GALT5 http://www.ncbi.nlm.nih.gov/gene/?term=9334 "B4Gal-T5, BETA4-GALT-IV, beta4Gal-T5, beta4GalT-V, gt-V" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041091 9352 TXNL1 http://www.ncbi.nlm.nih.gov/gene/?term=9352 "HEL-S-114, TRP32, TXL-1, TXNL, Txl" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041092 9352 TXNL1 http://www.ncbi.nlm.nih.gov/gene/?term=9352 "HEL-S-114, TRP32, TXL-1, TXNL, Txl" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041093 9353 SLIT2 http://www.ncbi.nlm.nih.gov/gene/?term=9353 "SLIL3, Slit-2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041094 9360 PPIG http://www.ncbi.nlm.nih.gov/gene/?term=9360 "CARS-Cyp, CYP, SCAF10, SRCyp" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041095 9360 PPIG http://www.ncbi.nlm.nih.gov/gene/?term=9360 "CARS-Cyp, CYP, SCAF10, SRCyp" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041096 93611 FBXO44 http://www.ncbi.nlm.nih.gov/gene/?term=93611 "FBG3, FBX30, FBX6A, Fbx44, Fbxo6a" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041097 93611 FBXO44 http://www.ncbi.nlm.nih.gov/gene/?term=93611 "FBG3, FBX30, FBX6A, Fbx44, Fbxo6a" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041098 93627 TBCK http://www.ncbi.nlm.nih.gov/gene/?term=93627 "HSPC302, IHPRF3L, TBCK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041099 93627 TBCK http://www.ncbi.nlm.nih.gov/gene/?term=93627 "HSPC302, IHPRF3L, TBCK" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041100 93664 CADPS2 http://www.ncbi.nlm.nih.gov/gene/?term=93664 CAPS2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041101 93664 CADPS2 http://www.ncbi.nlm.nih.gov/gene/?term=93664 CAPS2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041102 9373 PLAA http://www.ncbi.nlm.nih.gov/gene/?term=9373 "DOA1, NDMSBA, PLA2P, PLAP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041103 9373 PLAA http://www.ncbi.nlm.nih.gov/gene/?term=9373 "DOA1, NDMSBA, PLA2P, PLAP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041104 9378 NRXN1 http://www.ncbi.nlm.nih.gov/gene/?term=9378 "Hs.22998, PTHSL2, SCZD17" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041105 9378 NRXN1 http://www.ncbi.nlm.nih.gov/gene/?term=9378 "Hs.22998, PTHSL2, SCZD17" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041106 9397 NMT2 http://www.ncbi.nlm.nih.gov/gene/?term=9397 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041107 9397 NMT2 http://www.ncbi.nlm.nih.gov/gene/?term=9397 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041108 9403 SELENOF http://www.ncbi.nlm.nih.gov/gene/?term=9403 42993 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041109 9403 SELENOF http://www.ncbi.nlm.nih.gov/gene/?term=9403 42993 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041110 94104 PAXBP1 http://www.ncbi.nlm.nih.gov/gene/?term=94104 "BM020, C21orf66, FSAP105, GCFC, GCFC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041111 94104 PAXBP1 http://www.ncbi.nlm.nih.gov/gene/?term=94104 "BM020, C21orf66, FSAP105, GCFC, GCFC1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041112 94134 ARHGAP12 http://www.ncbi.nlm.nih.gov/gene/?term=94134 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041113 94134 ARHGAP12 http://www.ncbi.nlm.nih.gov/gene/?term=94134 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041114 9414 TJP2 http://www.ncbi.nlm.nih.gov/gene/?term=9414 "C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041115 94239 H2AFV http://www.ncbi.nlm.nih.gov/gene/?term=94239 "H2A.Z-2, H2AV" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041116 94239 H2AFV http://www.ncbi.nlm.nih.gov/gene/?term=94239 "H2A.Z-2, H2AV" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041117 9439 MED23 http://www.ncbi.nlm.nih.gov/gene/?term=9439 "ARC130, CRSP130, CRSP133, CRSP3, DRIP130, MRT18, SUR-2, SUR2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041118 9441 MED26 http://www.ncbi.nlm.nih.gov/gene/?term=9441 "CRSP7, CRSP70" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041119 9441 MED26 http://www.ncbi.nlm.nih.gov/gene/?term=9441 "CRSP7, CRSP70" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041120 9442 MED27 http://www.ncbi.nlm.nih.gov/gene/?term=9442 "CRAP34, CRSP34, CRSP8, MED3, TRAP37" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041121 9442 MED27 http://www.ncbi.nlm.nih.gov/gene/?term=9442 "CRAP34, CRSP34, CRSP8, MED3, TRAP37" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041122 9444 QKI http://www.ncbi.nlm.nih.gov/gene/?term=9444 "Hqk, QK, QK1, QK3, hqkI" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041123 9444 QKI http://www.ncbi.nlm.nih.gov/gene/?term=9444 "Hqk, QK, QK1, QK3, hqkI" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041124 9446 GSTO1 http://www.ncbi.nlm.nih.gov/gene/?term=9446 "GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041125 9451 EIF2AK3 http://www.ncbi.nlm.nih.gov/gene/?term=9451 "PEK, PERK, WRS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041126 9453 GGPS1 http://www.ncbi.nlm.nih.gov/gene/?term=9453 "GGPPS, GGPPS1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041127 9462 RASAL2 http://www.ncbi.nlm.nih.gov/gene/?term=9462 NGAP mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041128 9467 SH3BP5 http://www.ncbi.nlm.nih.gov/gene/?term=9467 "SAB, SH3BP-5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041129 9467 SH3BP5 http://www.ncbi.nlm.nih.gov/gene/?term=9467 "SAB, SH3BP-5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041130 9474 ATG5 http://www.ncbi.nlm.nih.gov/gene/?term=9474 "APG5, APG5-LIKE, APG5L, ASP, SCAR25, hAPG5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041131 9474 ATG5 http://www.ncbi.nlm.nih.gov/gene/?term=9474 "APG5, APG5-LIKE, APG5L, ASP, SCAR25, hAPG5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041132 9478 CABP1 http://www.ncbi.nlm.nih.gov/gene/?term=9478 "CALBRAIN, HCALB_BR" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041133 9478 CABP1 http://www.ncbi.nlm.nih.gov/gene/?term=9478 "CALBRAIN, HCALB_BR" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041134 949 SCARB1 http://www.ncbi.nlm.nih.gov/gene/?term=949 "CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041135 9497 SLC4A7 http://www.ncbi.nlm.nih.gov/gene/?term=9497 "NBC2, NBC3, NBCN1, SBC2, SLC4A6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041136 9501 RPH3AL http://www.ncbi.nlm.nih.gov/gene/?term=9501 NOC2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041137 9501 RPH3AL http://www.ncbi.nlm.nih.gov/gene/?term=9501 NOC2 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041138 9509 ADAMTS2 http://www.ncbi.nlm.nih.gov/gene/?term=9509 "ADAM-TS2, ADAMTS-2, ADAMTS-3, NPI, PC I-NP, PCI-NP, PCINP, PCPNI, PNPI" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041139 9509 ADAMTS2 http://www.ncbi.nlm.nih.gov/gene/?term=9509 "ADAM-TS2, ADAMTS-2, ADAMTS-3, NPI, PC I-NP, PCI-NP, PCINP, PCPNI, PNPI" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041140 9516 LITAF http://www.ncbi.nlm.nih.gov/gene/?term=9516 "PIG7, SIMPLE, TP53I7" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041141 9517 SPTLC2 http://www.ncbi.nlm.nih.gov/gene/?term=9517 "HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041142 9517 SPTLC2 http://www.ncbi.nlm.nih.gov/gene/?term=9517 "HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041143 9524 TECR http://www.ncbi.nlm.nih.gov/gene/?term=9524 "GPSN2, MRT14, SC2, TER" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041144 9524 TECR http://www.ncbi.nlm.nih.gov/gene/?term=9524 "GPSN2, MRT14, SC2, TER" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041145 9531 BAG3 http://www.ncbi.nlm.nih.gov/gene/?term=9531 "BAG-3, BIS, CAIR-1, MFM6" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041146 9531 BAG3 http://www.ncbi.nlm.nih.gov/gene/?term=9531 "BAG-3, BIS, CAIR-1, MFM6" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041147 9537 TP53I11 http://www.ncbi.nlm.nih.gov/gene/?term=9537 PIG11 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041148 9542 NRG2 http://www.ncbi.nlm.nih.gov/gene/?term=9542 "DON1, HRG2, NTAK" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041149 9542 NRG2 http://www.ncbi.nlm.nih.gov/gene/?term=9542 "DON1, HRG2, NTAK" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041150 9553 MRPL33 http://www.ncbi.nlm.nih.gov/gene/?term=9553 "C2orf1, L33mt, MRP-L33, RPL33L" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041151 9553 MRPL33 http://www.ncbi.nlm.nih.gov/gene/?term=9553 "C2orf1, L33mt, MRP-L33, RPL33L" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041152 9555 H2AFY http://www.ncbi.nlm.nih.gov/gene/?term=9555 "H2A.y, H2A/y, H2AF12M, MACROH2A1.1, mH2A1, macroH2A1.2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041153 9555 H2AFY http://www.ncbi.nlm.nih.gov/gene/?term=9555 "H2A.y, H2A/y, H2AF12M, MACROH2A1.1, mH2A1, macroH2A1.2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041154 9557 CHD1L http://www.ncbi.nlm.nih.gov/gene/?term=9557 "ALC1, CHDL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041155 9569 GTF2IRD1 http://www.ncbi.nlm.nih.gov/gene/?term=9569 "BEN, CREAM1, GTF3, MUSTRD1, RBAP2, WBS, WBSCR11, WBSCR12, hMusTRD1alpha1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041156 9569 GTF2IRD1 http://www.ncbi.nlm.nih.gov/gene/?term=9569 "BEN, CREAM1, GTF3, MUSTRD1, RBAP2, WBS, WBSCR11, WBSCR12, hMusTRD1alpha1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041157 957 ENTPD5 http://www.ncbi.nlm.nih.gov/gene/?term=957 "CD39L4, NTPDase-5, PCPH" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041158 957 ENTPD5 http://www.ncbi.nlm.nih.gov/gene/?term=957 "CD39L4, NTPDase-5, PCPH" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041159 9577 BABAM2 http://www.ncbi.nlm.nih.gov/gene/?term=9577 "BRCC4, BRCC45, BRE" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041160 9577 BABAM2 http://www.ncbi.nlm.nih.gov/gene/?term=9577 "BRCC4, BRCC45, BRE" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041161 9584 RBM39 http://www.ncbi.nlm.nih.gov/gene/?term=9584 "CAPER, CAPERalpha, FSAP59, HCC1, RNPC2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041162 9584 RBM39 http://www.ncbi.nlm.nih.gov/gene/?term=9584 "CAPER, CAPERalpha, FSAP59, HCC1, RNPC2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041163 9590 AKAP12 http://www.ncbi.nlm.nih.gov/gene/?term=9590 "AKAP250, SSeCKS" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041164 9590 AKAP12 http://www.ncbi.nlm.nih.gov/gene/?term=9590 "AKAP250, SSeCKS" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041165 960 CD44 http://www.ncbi.nlm.nih.gov/gene/?term=960 "CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041166 9611 NCOR1 http://www.ncbi.nlm.nih.gov/gene/?term=9611 "N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041167 9612 NCOR2 http://www.ncbi.nlm.nih.gov/gene/?term=9612 "CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041168 9612 NCOR2 http://www.ncbi.nlm.nih.gov/gene/?term=9612 "CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041169 9628 RGS6 http://www.ncbi.nlm.nih.gov/gene/?term=9628 "GAP, HA117, S914" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041170 9628 RGS6 http://www.ncbi.nlm.nih.gov/gene/?term=9628 "GAP, HA117, S914" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041171 9630 GNA14 http://www.ncbi.nlm.nih.gov/gene/?term=9630 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041172 9630 GNA14 http://www.ncbi.nlm.nih.gov/gene/?term=9630 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041173 9643 MORF4L2 http://www.ncbi.nlm.nih.gov/gene/?term=9643 "MORFL2, MRGX" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041174 9644 SH3PXD2A http://www.ncbi.nlm.nih.gov/gene/?term=9644 "FISH, SH3MD1, TKS5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041175 9644 SH3PXD2A http://www.ncbi.nlm.nih.gov/gene/?term=9644 "FISH, SH3MD1, TKS5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041176 9647 PPM1F http://www.ncbi.nlm.nih.gov/gene/?term=9647 "CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041177 9647 PPM1F http://www.ncbi.nlm.nih.gov/gene/?term=9647 "CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041178 9649 RALGPS1 http://www.ncbi.nlm.nih.gov/gene/?term=9649 "RALGEF2A, RALGPS1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041179 9649 RALGPS1 http://www.ncbi.nlm.nih.gov/gene/?term=9649 "RALGEF2A, RALGPS1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041180 965 CD58 http://www.ncbi.nlm.nih.gov/gene/?term=965 "LFA-3, LFA3, ag3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041181 965 CD58 http://www.ncbi.nlm.nih.gov/gene/?term=965 "LFA-3, LFA3, ag3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041182 9650 MTFR1 http://www.ncbi.nlm.nih.gov/gene/?term=9650 "CHPPR, FAM54A2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041183 9650 MTFR1 http://www.ncbi.nlm.nih.gov/gene/?term=9650 "CHPPR, FAM54A2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041184 9657 IQCB1 http://www.ncbi.nlm.nih.gov/gene/?term=9657 "NPHP5, PIQ, SLSN5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041185 9657 IQCB1 http://www.ncbi.nlm.nih.gov/gene/?term=9657 "NPHP5, PIQ, SLSN5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041186 9667 SAFB2 http://www.ncbi.nlm.nih.gov/gene/?term=9667 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041187 9667 SAFB2 http://www.ncbi.nlm.nih.gov/gene/?term=9667 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041188 9675 TTI1 http://www.ncbi.nlm.nih.gov/gene/?term=9675 "KIAA0406, smg-10" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041189 9675 TTI1 http://www.ncbi.nlm.nih.gov/gene/?term=9675 "KIAA0406, smg-10" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041190 96764 TGS1 http://www.ncbi.nlm.nih.gov/gene/?term=96764 "NCOA6IP, PIMT, PIPMT" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041191 96764 TGS1 http://www.ncbi.nlm.nih.gov/gene/?term=96764 "NCOA6IP, PIMT, PIPMT" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041192 9678 PHF14 http://www.ncbi.nlm.nih.gov/gene/?term=9678 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041193 9686 VGLL4 http://www.ncbi.nlm.nih.gov/gene/?term=9686 VGL-4 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041194 9686 VGLL4 http://www.ncbi.nlm.nih.gov/gene/?term=9686 VGL-4 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041195 9687 GREB1 http://www.ncbi.nlm.nih.gov/gene/?term=9687 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041196 9687 GREB1 http://www.ncbi.nlm.nih.gov/gene/?term=9687 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041197 9690 UBE3C http://www.ncbi.nlm.nih.gov/gene/?term=9690 HECTH2 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041198 9694 EMC2 http://www.ncbi.nlm.nih.gov/gene/?term=9694 "KIAA0103, TTC35" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041199 9695 EDEM1 http://www.ncbi.nlm.nih.gov/gene/?term=9695 EDEM mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041200 9698 PUM1 http://www.ncbi.nlm.nih.gov/gene/?term=9698 "HSPUM, PUMH, PUMH1, PUML1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041201 9698 PUM1 http://www.ncbi.nlm.nih.gov/gene/?term=9698 "HSPUM, PUMH, PUMH1, PUML1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041202 9702 CEP57 http://www.ncbi.nlm.nih.gov/gene/?term=9702 "MVA2, PIG8, TSP57" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041203 9727 RAB11FIP3 http://www.ncbi.nlm.nih.gov/gene/?term=9727 "CART1, Rab11-FIP3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041204 9727 RAB11FIP3 http://www.ncbi.nlm.nih.gov/gene/?term=9727 "CART1, Rab11-FIP3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041205 9734 HDAC9 http://www.ncbi.nlm.nih.gov/gene/?term=9734 "HD7, HD7b, HD9, HDAC, HDAC7, HDAC7BB, HDAC9FL, HDRP, MITR, HDAC9" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041206 9734 HDAC9 http://www.ncbi.nlm.nih.gov/gene/?term=9734 "HD7, HD7b, HD9, HDAC, HDAC7, HDAC7BB, HDAC9FL, HDRP, MITR, HDAC9" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041207 9736 USP34 http://www.ncbi.nlm.nih.gov/gene/?term=9736 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041208 9746 CLSTN3 http://www.ncbi.nlm.nih.gov/gene/?term=9746 "CDHR14, CSTN3, alcbeta" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041209 9746 CLSTN3 http://www.ncbi.nlm.nih.gov/gene/?term=9746 "CDHR14, CSTN3, alcbeta" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041210 9750 RIPOR2 http://www.ncbi.nlm.nih.gov/gene/?term=9750 "C6orf32, DFNB104, DIFF40, DIFF48, FAM65B, MYONAP, PL48" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041211 9750 RIPOR2 http://www.ncbi.nlm.nih.gov/gene/?term=9750 "C6orf32, DFNB104, DIFF40, DIFF48, FAM65B, MYONAP, PL48" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041212 9759 HDAC4 http://www.ncbi.nlm.nih.gov/gene/?term=9759 "AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041213 9759 HDAC4 http://www.ncbi.nlm.nih.gov/gene/?term=9759 "AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041214 9766 SUSD6 http://www.ncbi.nlm.nih.gov/gene/?term=9766 "DRAGO, KIAA0247" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041215 9768 PCLAF http://www.ncbi.nlm.nih.gov/gene/?term=9768 "KIAA0101, L5, NS5ATP9, OEATC, OEATC-1, OEATC1, PAF, PAF15, p15(PAF), p15/PAF, p15PAF" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041216 9768 PCLAF http://www.ncbi.nlm.nih.gov/gene/?term=9768 "KIAA0101, L5, NS5ATP9, OEATC, OEATC-1, OEATC1, PAF, PAF15, p15(PAF), p15/PAF, p15PAF" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041217 9772 TMEM94 http://www.ncbi.nlm.nih.gov/gene/?term=9772 KIAA0195 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041218 9778 KIAA0232 http://www.ncbi.nlm.nih.gov/gene/?term=9778 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041219 9778 KIAA0232 http://www.ncbi.nlm.nih.gov/gene/?term=9778 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041220 9779 TBC1D5 http://www.ncbi.nlm.nih.gov/gene/?term=9779 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041221 9779 TBC1D5 http://www.ncbi.nlm.nih.gov/gene/?term=9779 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041222 9781 RNF144A http://www.ncbi.nlm.nih.gov/gene/?term=9781 "RNF144, UBCE7IP4, hUIP4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041223 9781 RNF144A http://www.ncbi.nlm.nih.gov/gene/?term=9781 "RNF144, UBCE7IP4, hUIP4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041224 9782 MATR3 http://www.ncbi.nlm.nih.gov/gene/?term=9782 "ALS21, MPD2, VCPDM" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041225 9782 MATR3 http://www.ncbi.nlm.nih.gov/gene/?term=9782 "ALS21, MPD2, VCPDM" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041226 9783 RIMS3 http://www.ncbi.nlm.nih.gov/gene/?term=9783 "NIM3, RIM3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041227 9783 RIMS3 http://www.ncbi.nlm.nih.gov/gene/?term=9783 "NIM3, RIM3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041228 9786 KIAA0586 http://www.ncbi.nlm.nih.gov/gene/?term=9786 "JBTS23, SRTD14, Talpid3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041229 9786 KIAA0586 http://www.ncbi.nlm.nih.gov/gene/?term=9786 "JBTS23, SRTD14, Talpid3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041230 9791 PTDSS1 http://www.ncbi.nlm.nih.gov/gene/?term=9791 "LMHD, PSS1, PSSA" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041231 9793 CKAP5 http://www.ncbi.nlm.nih.gov/gene/?term=9793 "CHTOG, MSPS, TOG, TOGp, ch-TOG" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041232 9793 CKAP5 http://www.ncbi.nlm.nih.gov/gene/?term=9793 "CHTOG, MSPS, TOG, TOGp, ch-TOG" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041233 9794 MAML1 http://www.ncbi.nlm.nih.gov/gene/?term=9794 "Mam-1, Mam1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041234 9794 MAML1 http://www.ncbi.nlm.nih.gov/gene/?term=9794 "Mam-1, Mam1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041235 9798 IST1 http://www.ncbi.nlm.nih.gov/gene/?term=9798 OLC1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041236 9798 IST1 http://www.ncbi.nlm.nih.gov/gene/?term=9798 OLC1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041237 98 ACYP2 http://www.ncbi.nlm.nih.gov/gene/?term=98 "ACYM, ACYP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041238 98 ACYP2 http://www.ncbi.nlm.nih.gov/gene/?term=98 "ACYM, ACYP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041239 9801 MRPL19 http://www.ncbi.nlm.nih.gov/gene/?term=9801 "L19mt, MRP-L15, MRP-L19, MRPL15, RLX1, RPML15" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041240 9805 SCRN1 http://www.ncbi.nlm.nih.gov/gene/?term=9805 SES1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041241 9805 SCRN1 http://www.ncbi.nlm.nih.gov/gene/?term=9805 SES1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041242 9811 CTIF http://www.ncbi.nlm.nih.gov/gene/?term=9811 "Gm672, KIAA0427" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041243 9811 CTIF http://www.ncbi.nlm.nih.gov/gene/?term=9811 "Gm672, KIAA0427" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041244 9815 GIT2 http://www.ncbi.nlm.nih.gov/gene/?term=9815 "CAT-2, CAT2, PKL" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041245 9815 GIT2 http://www.ncbi.nlm.nih.gov/gene/?term=9815 "CAT-2, CAT2, PKL" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041246 9819 TSC22D2 http://www.ncbi.nlm.nih.gov/gene/?term=9819 "TILZ4a, TILZ4b, TILZ4c" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041247 9844 ELMO1 http://www.ncbi.nlm.nih.gov/gene/?term=9844 "CED-12, CED12, ELMO-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041248 9844 ELMO1 http://www.ncbi.nlm.nih.gov/gene/?term=9844 "CED-12, CED12, ELMO-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041249 9847 C2CD5 http://www.ncbi.nlm.nih.gov/gene/?term=9847 "CDP138, KIAA0528" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041250 9855 FARP2 http://www.ncbi.nlm.nih.gov/gene/?term=9855 "FIR, FRG, PLEKHC3" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041251 9855 FARP2 http://www.ncbi.nlm.nih.gov/gene/?term=9855 "FIR, FRG, PLEKHC3" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041252 9877 ZC3H11A http://www.ncbi.nlm.nih.gov/gene/?term=9877 ZC3HDC11A mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041253 9877 ZC3H11A http://www.ncbi.nlm.nih.gov/gene/?term=9877 ZC3HDC11A mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041254 9882 TBC1D4 http://www.ncbi.nlm.nih.gov/gene/?term=9882 "AS160, NIDDM5" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041255 9882 TBC1D4 http://www.ncbi.nlm.nih.gov/gene/?term=9882 "AS160, NIDDM5" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041256 9886 RHOBTB1 http://www.ncbi.nlm.nih.gov/gene/?term=9886 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041257 9887 SMG7 http://www.ncbi.nlm.nih.gov/gene/?term=9887 "C1orf16, EST1C, SGA56M" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041258 9887 SMG7 http://www.ncbi.nlm.nih.gov/gene/?term=9887 "C1orf16, EST1C, SGA56M" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041259 9895 TECPR2 http://www.ncbi.nlm.nih.gov/gene/?term=9895 "KIAA0329, SPG49" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041260 9897 WASHC5 http://www.ncbi.nlm.nih.gov/gene/?term=9897 "KIAA0196, RTSC, RTSC1, SPG8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041261 9901 SRGAP3 http://www.ncbi.nlm.nih.gov/gene/?term=9901 "ARHGAP14, MEGAP, SRGAP2, WRP" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041262 9901 SRGAP3 http://www.ncbi.nlm.nih.gov/gene/?term=9901 "ARHGAP14, MEGAP, SRGAP2, WRP" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041263 9904 RBM19 http://www.ncbi.nlm.nih.gov/gene/?term=9904 Mrd1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041264 9910 RABGAP1L http://www.ncbi.nlm.nih.gov/gene/?term=9910 "HHL, TBC1D18" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041265 9912 ARHGAP44 http://www.ncbi.nlm.nih.gov/gene/?term=9912 "NPC-A-10, RICH2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041266 9912 ARHGAP44 http://www.ncbi.nlm.nih.gov/gene/?term=9912 "NPC-A-10, RICH2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041267 9922 IQSEC1 http://www.ncbi.nlm.nih.gov/gene/?term=9922 "ARF-GEP100, ARFGEP100, BRAG2, GEP100" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041268 9922 IQSEC1 http://www.ncbi.nlm.nih.gov/gene/?term=9922 "ARF-GEP100, ARFGEP100, BRAG2, GEP100" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041269 9926 LPGAT1 http://www.ncbi.nlm.nih.gov/gene/?term=9926 "FAM34A, FAM34A1, NET8" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041270 9943 OXSR1 http://www.ncbi.nlm.nih.gov/gene/?term=9943 OSR1 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041271 9943 OXSR1 http://www.ncbi.nlm.nih.gov/gene/?term=9943 OSR1 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041272 9945 GFPT2 http://www.ncbi.nlm.nih.gov/gene/?term=9945 "GFAT, GFAT 2, GFAT2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041273 9945 GFPT2 http://www.ncbi.nlm.nih.gov/gene/?term=9945 "GFAT, GFAT 2, GFAT2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041274 9948 WDR1 http://www.ncbi.nlm.nih.gov/gene/?term=9948 "AIP1, HEL-S-52, NORI-1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041275 9948 WDR1 http://www.ncbi.nlm.nih.gov/gene/?term=9948 "AIP1, HEL-S-52, NORI-1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041276 9949 AMMECR1 http://www.ncbi.nlm.nih.gov/gene/?term=9949 "AMMERC1, MFHIEN" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041277 9949 AMMECR1 http://www.ncbi.nlm.nih.gov/gene/?term=9949 "AMMERC1, MFHIEN" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041278 9953 HS3ST3B1 http://www.ncbi.nlm.nih.gov/gene/?term=9953 "3-OST-3B, 3OST3B1, h3-OST-3B" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041279 9957 HS3ST1 http://www.ncbi.nlm.nih.gov/gene/?term=9957 "3OST, 3OST1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041280 9957 HS3ST1 http://www.ncbi.nlm.nih.gov/gene/?term=9957 "3OST, 3OST1" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041281 9958 USP15 http://www.ncbi.nlm.nih.gov/gene/?term=9958 "UNPH-2, UNPH4" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041282 9958 USP15 http://www.ncbi.nlm.nih.gov/gene/?term=9958 "UNPH-2, UNPH4" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041283 9961 MVP http://www.ncbi.nlm.nih.gov/gene/?term=9961 "LRP, VAULT1" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041284 9962 SLC23A2 http://www.ncbi.nlm.nih.gov/gene/?term=9962 "NBTL1, SLC23A1, SVCT2, YSPL2, hSVCT2" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041285 9962 SLC23A2 http://www.ncbi.nlm.nih.gov/gene/?term=9962 "NBTL1, SLC23A1, SVCT2, YSPL2, hSVCT2" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041286 9967 THRAP3 http://www.ncbi.nlm.nih.gov/gene/?term=9967 "BCLAF2, TRAP150" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041287 9969 MED13 http://www.ncbi.nlm.nih.gov/gene/?term=9969 "ARC250, DRIP250, HSPC221, THRAP1, TRAP240" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041288 999 CDH1 http://www.ncbi.nlm.nih.gov/gene/?term=999 "Arc-1, CD324, CDHE, ECAD, LCAM, UVO" mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041289 999 CDH1 http://www.ncbi.nlm.nih.gov/gene/?term=999 "Arc-1, CD324, CDHE, ECAD, LCAM, UVO" mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041290 ENSG00000178642 AL513477.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000178642 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041291 ENSG00000178642 AL513477.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000178642 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041292 ENSG00000197585 AC107218.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000197585 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041293 ENSG00000197585 AC107218.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000197585 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041294 ENSG00000197604 AC022532.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000197604 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041295 ENSG00000197604 AC022532.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000197604 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041296 ENSG00000203691 AC092811.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000203691 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041297 ENSG00000204044 RP11-465L10.10 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000204044 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041298 ENSG00000204044 RP11-465L10.10 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000204044 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041299 ENSG00000204620 AC115618.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000204620 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041300 ENSG00000204620 AC115618.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000204620 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041301 ENSG00000217075 AC007401.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000217075 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041302 ENSG00000217075 AC007401.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000217075 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041303 ENSG00000222007 AC064874.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000222007 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041304 ENSG00000222007 AC064874.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000222007 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041305 ENSG00000223774 RP11-307B6.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000223774 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041306 ENSG00000223774 RP11-307B6.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000223774 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041307 ENSG00000224063 AC007319.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224063 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041308 ENSG00000224152 AC009506.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224152 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041309 ENSG00000224152 AC009506.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224152 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041310 ENSG00000225075 RP11-426L16.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225075 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041311 ENSG00000225075 RP11-426L16.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225075 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041312 ENSG00000225138 CTD-2228K2.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225138 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041313 ENSG00000225138 CTD-2228K2.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225138 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041314 ENSG00000225721 RP11-269F19.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225721 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041315 ENSG00000225721 RP11-269F19.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225721 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041316 ENSG00000225798 AC025918.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225798 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041317 ENSG00000225798 AC025918.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225798 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041318 ENSG00000225886 RP11-288L9.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225886 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041319 ENSG00000225886 RP11-288L9.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225886 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041320 ENSG00000226648 RP1-1J6.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000226648 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041321 ENSG00000227155 RP11-165F24.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000227155 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041322 ENSG00000227155 RP11-165F24.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000227155 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041323 ENSG00000228060 RP11-69E11.8 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228060 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041324 ENSG00000228061 Z83001.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228061 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041325 ENSG00000228061 Z83001.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228061 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041326 ENSG00000228124 RP1-122O8.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228124 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041327 ENSG00000228124 RP1-122O8.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228124 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041328 ENSG00000228274 RP3-508I15.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228274 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041329 ENSG00000228274 RP3-508I15.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228274 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041330 ENSG00000228737 AC008781.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228737 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041331 ENSG00000228737 AC008781.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228737 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041332 ENSG00000229044 RP11-266K22.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000229044 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041333 ENSG00000229044 RP11-266K22.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000229044 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041334 ENSG00000229821 RP11-567E21.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000229821 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041335 ENSG00000229821 RP11-567E21.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000229821 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041336 ENSG00000230325 RP11-385F5.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230325 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041337 ENSG00000230325 RP11-385F5.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230325 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041338 ENSG00000230424 RP1-43E13.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230424 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041339 ENSG00000230424 RP1-43E13.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230424 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041340 ENSG00000230733 AC092171.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230733 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041341 ENSG00000230733 AC092171.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230733 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041342 ENSG00000231064 RP11-263K19.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000231064 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041343 ENSG00000231064 RP11-263K19.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000231064 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041344 ENSG00000231840 AC073342.12 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000231840 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041345 ENSG00000231840 AC073342.12 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000231840 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041346 ENSG00000231993 RP1-85F18.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000231993 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041347 ENSG00000232194 RP1-313L4.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000232194 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041348 ENSG00000232194 RP1-313L4.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000232194 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041349 ENSG00000232623 AP000266.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000232623 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041350 ENSG00000232623 AP000266.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000232623 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041351 ENSG00000234055 RP11-247A12.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234055 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041352 ENSG00000234084 RP3-388E23.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234084 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041353 ENSG00000234084 RP3-388E23.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234084 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041354 ENSG00000234136 AC055764.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234136 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041355 ENSG00000234136 AC055764.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234136 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041356 ENSG00000234428 RP11-666F17.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234428 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041357 ENSG00000234428 RP11-666F17.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234428 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041358 ENSG00000234961 RP11-124N14.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234961 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041359 ENSG00000234961 RP11-124N14.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234961 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041360 ENSG00000235085 AC091153.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000235085 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041361 ENSG00000235085 AC091153.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000235085 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041362 ENSG00000235513 RP4-756G23.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000235513 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041363 ENSG00000235790 RP11-73M7.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000235790 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041364 ENSG00000235790 RP11-73M7.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000235790 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041365 ENSG00000236015 AC011290.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236015 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041366 ENSG00000236015 AC011290.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236015 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041367 ENSG00000236031 RP11-269F20.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236031 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041368 ENSG00000236031 RP11-269F20.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236031 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041369 ENSG00000236364 RP11-525G13.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236364 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041370 ENSG00000236364 RP11-525G13.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236364 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041371 ENSG00000236432 AC097662.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236432 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041372 ENSG00000236432 AC097662.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236432 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041373 ENSG00000236498 AC107081.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236498 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041374 ENSG00000236498 AC107081.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236498 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041375 ENSG00000236526 RP4-742J24.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236526 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041376 ENSG00000236782 RP11-96L14.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236782 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041377 ENSG00000236782 RP11-96L14.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236782 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041378 ENSG00000237234 RP1-142L7.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237234 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041379 ENSG00000237234 RP1-142L7.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237234 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041380 ENSG00000237719 RP1-179N16.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237719 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041381 ENSG00000237781 RP11-54A4.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237781 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041382 ENSG00000237781 RP11-54A4.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237781 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041383 ENSG00000237978 RP11-385J1.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237978 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041384 ENSG00000237978 RP11-385J1.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237978 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041385 ENSG00000238221 RP11-69L16.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000238221 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041386 ENSG00000238246 RP11-575A19.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000238246 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041387 ENSG00000238279 BX470102.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000238279 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041388 ENSG00000238279 BX470102.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000238279 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041389 ENSG00000240291 RP11-499P20.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000240291 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041390 ENSG00000240291 RP11-499P20.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000240291 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041391 ENSG00000240401 AC012358.8 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000240401 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041392 ENSG00000240401 AC012358.8 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000240401 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041393 ENSG00000240449 RP4-584D14.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000240449 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041394 ENSG00000240449 RP4-584D14.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000240449 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041395 ENSG00000240499 RP5-1101C3.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000240499 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041396 ENSG00000240499 RP5-1101C3.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000240499 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041397 ENSG00000240553 RP1-184J9.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000240553 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041398 ENSG00000240553 RP1-184J9.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000240553 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041399 ENSG00000242798 RP11-506M12.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000242798 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041400 ENSG00000242798 RP11-506M12.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000242798 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041401 ENSG00000242861 RP11-285F7.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000242861 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041402 ENSG00000242861 RP11-285F7.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000242861 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041403 ENSG00000243018 RP5-1070G24.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000243018 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041404 ENSG00000243018 RP5-1070G24.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000243018 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041405 ENSG00000243415 RP11-274H2.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000243415 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041406 ENSG00000244513 CTD-2013N24.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000244513 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041407 ENSG00000244513 CTD-2013N24.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000244513 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041408 ENSG00000246889 AP000487.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000246889 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041409 ENSG00000247925 RP3-510L9.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000247925 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041410 ENSG00000247925 RP3-510L9.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000247925 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041411 ENSG00000248445 CTB-118N6.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000248445 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041412 ENSG00000248647 RP11-331K21.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000248647 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041413 ENSG00000248647 RP11-331K21.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000248647 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041414 ENSG00000248710 RP11-432B6.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000248710 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041415 ENSG00000249084 RP11-376O6.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000249084 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041416 ENSG00000250309 CTC-345K18.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250309 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041417 ENSG00000250309 CTC-345K18.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250309 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041418 ENSG00000250751 RP11-613C6.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250751 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041419 ENSG00000250751 RP11-613C6.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250751 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041420 ENSG00000251186 RP11-689P11.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000251186 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041421 ENSG00000251186 RP11-689P11.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000251186 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041422 ENSG00000251307 RP11-506H20.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000251307 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041423 ENSG00000251307 RP11-506H20.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000251307 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041424 ENSG00000253667 RP11-30L15.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253667 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041425 ENSG00000253736 RP11-779O18.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253736 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041426 ENSG00000253921 CTB-113P19.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253921 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041427 ENSG00000253921 CTB-113P19.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253921 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041428 ENSG00000253972 RP11-4K16.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253972 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041429 ENSG00000253972 RP11-4K16.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253972 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041430 ENSG00000254459 RP11-91P24.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254459 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041431 ENSG00000254459 RP11-91P24.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254459 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041432 ENSG00000254548 RP11-429J17.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254548 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041433 ENSG00000254548 RP11-429J17.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254548 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041434 ENSG00000254733 RP11-317J19.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254733 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041435 ENSG00000254733 RP11-317J19.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254733 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041436 ENSG00000254966 RP11-1081L13.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254966 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041437 ENSG00000254966 RP11-1081L13.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254966 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041438 ENSG00000254981 RP11-350N15.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254981 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041439 ENSG00000254981 RP11-350N15.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254981 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041440 ENSG00000255125 RP11-685M7.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255125 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041441 ENSG00000255201 RP11-350N15.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255201 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041442 ENSG00000255201 RP11-350N15.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255201 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041443 ENSG00000255206 RP11-403D15.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255206 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041444 ENSG00000255443 RP1-68D18.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255443 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041445 ENSG00000255443 RP1-68D18.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255443 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041446 ENSG00000255539 CTA-797E19.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255539 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041447 ENSG00000255655 RP11-256L11.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255655 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041448 ENSG00000255692 RP1-127H14.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255692 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041449 ENSG00000255817 RP11-196H14.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255817 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041450 ENSG00000255817 RP11-196H14.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255817 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041451 ENSG00000255872 RP11-613M10.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255872 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041452 ENSG00000255872 RP11-613M10.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255872 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041453 ENSG00000255965 RP11-408I18.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255965 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041454 ENSG00000255965 RP11-408I18.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255965 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041455 ENSG00000256824 RP11-21A7A.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000256824 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041456 ENSG00000256824 RP11-21A7A.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000256824 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041457 ENSG00000257042 RP11-993B23.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000257042 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041458 ENSG00000257042 RP11-993B23.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000257042 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041459 ENSG00000257222 RP11-554E23.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000257222 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041460 ENSG00000257342 RP11-571M6.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000257342 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041461 ENSG00000257342 RP11-571M6.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000257342 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041462 ENSG00000257497 RP11-585P4.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000257497 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041463 ENSG00000257681 RP11-341G23.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000257681 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041464 ENSG00000257681 RP11-341G23.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000257681 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041465 ENSG00000258260 RP11-977G19.14 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000258260 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041466 ENSG00000258260 RP11-977G19.14 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000258260 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041467 ENSG00000258365 RP11-1105G2.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000258365 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041468 ENSG00000258365 RP11-1105G2.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000258365 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041469 ENSG00000258515 RP11-203M5.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000258515 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041470 ENSG00000258646 RP11-950C14.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000258646 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041471 ENSG00000258646 RP11-950C14.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000258646 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041472 ENSG00000258745 RP11-218E20.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000258745 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041473 ENSG00000258789 RP11-507K2.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000258789 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041474 ENSG00000258959 RP11-1017G21.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000258959 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041475 ENSG00000259081 RP11-488C13.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259081 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041476 ENSG00000259081 RP11-488C13.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259081 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041477 ENSG00000259088 CTD-2017C7.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259088 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041478 ENSG00000259088 CTD-2017C7.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259088 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041479 ENSG00000259279 CTD-2033D15.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259279 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041480 ENSG00000259279 CTD-2033D15.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259279 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041481 ENSG00000259322 RP11-762H8.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259322 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041482 ENSG00000259367 RP11-815J21.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259367 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041483 ENSG00000259367 RP11-815J21.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259367 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041484 ENSG00000259407 RP11-158M2.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259407 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041485 ENSG00000259407 RP11-158M2.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259407 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041486 ENSG00000259546 RP11-351M8.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259546 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041487 ENSG00000259577 RP11-430B1.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259577 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041488 ENSG00000259577 RP11-430B1.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259577 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041489 ENSG00000259627 RP11-244F12.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259627 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041490 ENSG00000259627 RP11-244F12.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259627 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041491 ENSG00000259723 RP5-823G15.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259723 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041492 ENSG00000259723 RP5-823G15.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259723 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041493 ENSG00000259755 RP11-505E24.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259755 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041494 ENSG00000259755 RP11-505E24.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259755 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041495 ENSG00000259901 RP5-991G20.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259901 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041496 ENSG00000259901 RP5-991G20.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259901 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041497 ENSG00000259939 RP11-77H9.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259939 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041498 ENSG00000259939 RP11-77H9.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259939 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041499 ENSG00000259940 CTD-3203P2.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000259940 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041500 ENSG00000260095 RP11-715J22.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260095 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041501 ENSG00000260095 RP11-715J22.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260095 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041502 ENSG00000260121 RP5-1142A6.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260121 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041503 ENSG00000260121 RP5-1142A6.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260121 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041504 ENSG00000260349 RP11-473I1.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260349 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041505 ENSG00000260349 RP11-473I1.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260349 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041506 ENSG00000260350 RP11-152P23.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260350 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041507 ENSG00000260350 RP11-152P23.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260350 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041508 ENSG00000260465 RP11-63M22.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260465 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041509 ENSG00000260465 RP11-63M22.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260465 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041510 ENSG00000260773 RP11-352G18.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260773 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041511 ENSG00000260853 RP11-264B17.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260853 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041512 ENSG00000260853 RP11-264B17.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260853 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041513 ENSG00000260927 RP11-459F6.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260927 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041514 ENSG00000260927 RP11-459F6.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000260927 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041515 ENSG00000261235 RP11-510J16.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000261235 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041516 ENSG00000261235 RP11-510J16.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000261235 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041517 ENSG00000261669 CTD-2515A14.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000261669 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041518 ENSG00000261669 CTD-2515A14.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000261669 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041519 ENSG00000261762 RP11-650L12.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000261762 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041520 ENSG00000261898 RP11-314A20.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000261898 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041521 ENSG00000261898 RP11-314A20.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000261898 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041522 ENSG00000262580 RP11-334C17.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000262580 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041523 ENSG00000262580 RP11-334C17.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000262580 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041524 ENSG00000263272 CTC-524C5.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000263272 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041525 ENSG00000263272 CTC-524C5.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000263272 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041526 ENSG00000263300 RP5-1029F21.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000263300 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041527 ENSG00000264031 RP11-68I3.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000264031 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041528 ENSG00000264031 RP11-68I3.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000264031 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041529 ENSG00000264044 RP11-192H23.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000264044 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041530 ENSG00000264044 RP11-192H23.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000264044 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041531 ENSG00000265445 RP11-849N15.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000265445 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041532 ENSG00000265490 RP11-806L2.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000265490 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041533 ENSG00000265907 RP11-737O24.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000265907 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041534 ENSG00000265907 RP11-737O24.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000265907 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041535 ENSG00000266903 CTB-171A8.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000266903 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041536 ENSG00000266978 CTD-2369P2.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000266978 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041537 ENSG00000266978 CTD-2369P2.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000266978 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041538 ENSG00000267009 RP11-120M18.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267009 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041539 ENSG00000267009 RP11-120M18.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267009 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041540 ENSG00000267025 AC015849.19 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267025 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041541 ENSG00000267025 AC015849.19 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267025 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041542 ENSG00000267049 AC002398.13 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267049 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041543 ENSG00000267049 AC002398.13 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267049 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041544 ENSG00000267249 RP11-973H7.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267249 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041545 ENSG00000267342 RP11-552F3.10 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267342 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041546 ENSG00000267342 RP11-552F3.10 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267342 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041547 ENSG00000267375 CTB-186G2.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267375 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041548 ENSG00000267375 CTB-186G2.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267375 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041549 ENSG00000267379 CTC-548K16.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267379 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041550 ENSG00000267379 CTC-548K16.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267379 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041551 ENSG00000267436 AC005786.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267436 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041552 ENSG00000267436 AC005786.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267436 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041553 ENSG00000267476 RP11-126O1.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267476 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041554 ENSG00000267787 RP11-35G9.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267787 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041555 ENSG00000267954 AP000349.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267954 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041556 ENSG00000268015 CTD-2525I3.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000268015 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041557 ENSG00000268015 CTD-2525I3.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000268015 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041558 ENSG00000268069 AC004466.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000268069 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041559 ENSG00000268069 AC004466.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000268069 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041560 ENSG00000268172 AL590452.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000268172 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041561 ENSG00000268189 AC005785.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000268189 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041562 ENSG00000268189 AC005785.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000268189 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041563 ENSG00000268833 AC011513.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000268833 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041564 ENSG00000268846 AC018867.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000268846 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041565 ENSG00000268846 AC018867.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000268846 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041566 ENSG00000268896 RP11-256I23.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000268896 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041567 ENSG00000269151 AC007193.8 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000269151 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041568 ENSG00000269151 AC007193.8 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000269151 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041569 ENSG00000269176 RP11-727F15.12 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000269176 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041570 ENSG00000269176 RP11-727F15.12 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000269176 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041571 ENSG00000269305 AL158147.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000269305 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041572 ENSG00000269305 AL158147.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000269305 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041573 ENSG00000269496 AC007919.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000269496 mRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). We also noted that a considerable fraction of mRNAs (16%) were detected exclusively in the nucleus." RLID00041574 ENSG00000269496 AC007919.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000269496 mRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). These mRNAs may include transcripts with a very rapid cytoplasmic turnover, those that are inefficiently transported to the cytoplasm, or those that are selectively retained in the nucleus as part of a post-transcriptional mechanism to regulate gene expression." RLID00041575 ENSG00000270110 RP5-1139B12.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000270110 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041576 ENSG00000270110 RP5-1139B12.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000270110 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041577 ENSG00000270706 CTD-2301A4.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000270706 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041578 ENSG00000270706 CTD-2301A4.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000270706 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041579 ENSG00000271554 RP4-665N4.8 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000271554 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041580 ENSG00000271554 RP4-665N4.8 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000271554 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041581 ENSG00000271725 RP11-761I4.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000271725 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041582 ENSG00000271725 RP11-761I4.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000271725 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041583 ENSG00000271774 RP4-678D15.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000271774 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041584 ENSG00000271774 RP4-678D15.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000271774 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041585 ENSG00000271795 CTC-251D13.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000271795 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041586 ENSG00000271806 RP5-892K4.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000271806 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041587 ENSG00000271806 RP5-892K4.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000271806 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041588 ENSG00000271870 RP11-97C16.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000271870 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041589 ENSG00000271870 RP11-97C16.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000271870 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041590 ENSG00000271984 RP3-337O18.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000271984 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041591 ENSG00000271984 RP3-337O18.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000271984 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041592 ENSG00000272054 RP11-423P10.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272054 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041593 ENSG00000272072 CTA-363E19.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272072 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041594 ENSG00000272072 CTA-363E19.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272072 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041595 ENSG00000272173 U47924.31 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272173 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041596 ENSG00000272173 U47924.31 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272173 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041597 ENSG00000272182 RP11-802O23.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272182 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041598 ENSG00000272182 RP11-802O23.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272182 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041599 ENSG00000272356 RP5-1112D6.8 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272356 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041600 ENSG00000272367 CTC-428H11.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272367 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041601 ENSG00000272582 RP5-1039K5.17 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272582 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041602 ENSG00000272582 RP5-1039K5.17 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272582 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041603 ENSG00000272760 RP11-5C23.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272760 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041604 ENSG00000272789 RP11-286H15.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272789 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041605 ENSG00000272789 RP11-286H15.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272789 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041606 ENSG00000272910 RP11-15L13.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272910 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041607 ENSG00000272910 RP11-15L13.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272910 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041608 ENSG00000272918 CTB-152G17.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272918 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041609 ENSG00000272918 CTB-152G17.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272918 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041610 ENSG00000272990 RP11-305K5.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272990 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041611 ENSG00000272990 RP11-305K5.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272990 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041612 ENSG00000273137 RP3-402G11.28 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000273137 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041613 ENSG00000273449 RP11-218F10.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000273449 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041614 ENSG00000273449 RP11-218F10.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000273449 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041615 ENSG00000273466 RP11-548H3.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000273466 lncRNA Homo sapiens 26151857 Nucleus HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). Forty-one percent of the intronic lncRNAs and 25% of the antisense lncRNAs were detected exclusively in the nuclei of HeLa cells." RLID00041616 ENSG00000273466 RP11-548H3.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000273466 lncRNA Homo sapiens 26151857 Cytoplasm HeLa cells 44k oligoarray "We used a re-annotated version of a previously described custom-designed 44k intron-exon oligoarray19 that interrogates 6,322 intragenic transcripts with the same orientation as the respective mRNAs (intronic lncRNAs), as well as 10,482 transcripts with an antisense orientation relative to the mRNAs (antisense lncRNAs) and 6,360 protein-coding mRNAs. Data were collected from GEO(GSE62989, GSE62984, GSE62963, GSE62985, GSE62959, GSE62955, and GSE62958). It is interesting to note that the majority of the lncRNAs (58% and 73% of the intronic and antisense lncRNAs, respectively) were also detected in the cytoplasm." RLID00041617 51352 WT1-AS http://www.ncbi.nlm.nih.gov/gene/?term=51352 "WIT1, WIT-1, WT1AS, WT1-AS1" lncRNA Homo sapiens 26462627 Nucleus Huh7 and HepG2 cells FISH The transcript of WT1-AS was located primarily in the nucleus of Huh7 and HepG2 cells. RLID00041618 77395 9530018H14Rik http://www.ncbi.nlm.nih.gov/gene/?term=77395 lncRNA-HIT mRNA Mus musculus 26633036 Nucleus Embryo RNA-FISH Analysis of LncRNA-HIT's subcellular localization by single molecule RNA FISH detected the lncRNA in the nucleus where it was distributed diffusely and in larger foci in the limb bud mesenchyme. RLID00041619 647979 NORAD http://www.ncbi.nlm.nih.gov/gene/?term=647979 LINC00657 lncRNA Homo sapiens 26724866 Cytoplasm cell lines RT-PCR "Furthermore, subcellular fractionation and single molecule RNA FISH demonstrated a nearly exclusively cytoplasmic localization of the NORAD RNA." RLID00041620 100316868 HOTTIP http://www.ncbi.nlm.nih.gov/gene/?term=100316868 "HOXA-AS6, HOXA13-AS1, NCRNA00213" lncRNA Homo sapiens 26807954 Nucleus HepG2 cell lines/SMMC7721 qRT-PCR HOTTIP was detected predominantly in the nuclear fraction as U6RNA did in HCC cells. RLID00041621 100302740 FAS-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100302740 "SAF, FASAS, FAS-AS" lncRNA Homo sapiens 26885613 Nucleus HeLa cells qPCR We show that Saf is localized in the nucleus where it interacts with Fas receptor pre-mRNA and human splicing factor 45 (SPF45) to facilitate alternative splicing and exclusion of exon 6. RLID00041622 100302740 FAS-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100302740 "SAF, FASAS, FAS-AS" lncRNA Homo sapiens 26885613 Nucleus HeLa cells qPCR We show that Saf is localized in the nucleus where it interacts with Fas receptor pre-mRNA and human splicing factor 45 (SPF45) to facilitate alternative splicing and exclusion of exon 6. RLID00041623 4498 MT1JP http://www.ncbi.nlm.nih.gov/gene/?term=4498 "MT1, MT1J, MT1NP, MTB" lncRNA Homo sapiens 26909858 Cytoplasm L02 cells RNA-FISH "We first determined the subcellular distribution of MT1JP by RNA fluorescence in situ hybridization (RNA-FISH), and found that most of the MT1JP transcripts were located in the cytoplasm. " RLID00041624 4498 MT1JP http://www.ncbi.nlm.nih.gov/gene/?term=4498 "MT1, MT1J, MT1NP, MTB" lncRNA Homo sapiens 26909858 Cytoplasm L02 cells qRT-PCR "Moreover, we confirmed this observation by quantifying the expression ratio of MT1JP in cytoplasmic and nuclear fractions with qRT-PCR." RLID00041625 100048912 CDKN2B-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100048912 "ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS" lncRNA Homo sapiens 26937624 Nucleus NCM356 qRT-PCR "We identified 329 lncRNAs with increased and 126 lncRNAs with decreased expression in active UC tissues compared with normal control tissues, including the most significantly upregulated (BC012900, AK001903, and AK023330) and downregulated (BC029135, CDKN2B-AS1, and BC062296) transcripts. The microarray raw data and normalized data have been deposited in NCBI Gene Expression Omnibus (GEO) database under accession number GSE 72221. We found that most of the lncRNAs are localized to the nucleus." RLID00041626 114041 B3GALT5-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=114041 C21orf88 lncRNA Homo sapiens 26937624 Cytoplasm NCM356 qRT-PCR "The NCode human noncoding RNA (ncRNA) Microarray V2 (Invitrogen) was used to assess the expression of 17,112 lncRNAs and 22,074 mRNA in individual RNA samples from each patient.The microarray raw data and normalized data have been deposited in NCBI Gene Expression Omnibus (GEO) database under accession number GSE72221. Most lncRNAs demonstrate predominant nuclear expression, whereas DIOA3AS and BC062296 demonstrated higher abundance in cytoplasm." RLID00041627 114041 B3GALT5-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=114041 C21orf88 lncRNA Homo sapiens 26937624 Nucleus NCM356 qRT-PCR "The NCode human noncoding RNA (ncRNA) Microarray V2 (Invitrogen) was used to assess the expression of 17,112 lncRNAs and 22,074 mRNA in individual RNA samples from each patient. The microarray raw data and normalized data have been deposited in NCBI Gene Expression Omnibus (GEO) database under accession number GSE72221. We found that most of the lncRNAs are localized to the nucleus." RLID00041628 1846 DUSP4 http://www.ncbi.nlm.nih.gov/gene/?term=1846 "HVH2, MKP-2, MKP2, TYP" mRNA Homo sapiens 26937624 Nucleus NCM356 qRT-PCR "The NCode human noncoding RNA (ncRNA) Microarray V2 (Invitrogen) was used to assess the expression of 17,112 lncRNAs and 22,074 mRNA in individual RNA samples from each patient. The microarray raw data and normalized data have been deposited in NCBI Gene Expression Omnibus (GEO) database under accession number GSE72221. We found that most of the lncRNAs are localized to the nucleus." RLID00041629 301 ANXA1 http://www.ncbi.nlm.nih.gov/gene/?term=301 "ANX1, LPC1" mRNA Homo sapiens 26937624 Nucleus NCM356 qRT-PCR "The NCode human noncoding RNA (ncRNA) Microarray V2 (Invitrogen) was used to assess the expression of 17,112 lncRNAs and 22,074 mRNA in individual RNA samples from each patient. The microarray raw data and normalized data have been deposited in NCBI Gene Expression Omnibus (GEO) database under accession number GSE72221. We found that most of the lncRNAs are localized to the nucleus." RLID00041630 3624 INHBA http://www.ncbi.nlm.nih.gov/gene/?term=3624 "EDF, FRP" mRNA Homo sapiens 26937624 Nucleus NCM356 qRT-PCR "The NCode human noncoding RNA (ncRNA) Microarray V2 (Invitrogen) was used to assess the expression of 17,112 lncRNAs and 22,074 mRNA in individual RNA samples from each patient. The microarray raw data and normalized data have been deposited in NCBI Gene Expression Omnibus (GEO) database under accession number GSE72221. We found that most of the lncRNAs are localized to the nucleus." RLID00041631 3752 KCND3 http://www.ncbi.nlm.nih.gov/gene/?term=3752 "BRGDA9L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22, KCND3" mRNA Homo sapiens 26937624 Nucleus NCM356 qRT-PCR "The NCode human noncoding RNA (ncRNA) Microarray V2 (Invitrogen) was used to assess the expression of 17,112 lncRNAs and 22,074 mRNA in individual RNA samples from each patient. The microarray raw data and normalized data have been deposited in NCBI Gene Expression Omnibus (GEO) database under accession number GSE72221. We found that most of the lncRNAs are localized to the nucleus." RLID00041632 64150 DIO3OS http://www.ncbi.nlm.nih.gov/gene/?term=64150 "DIO3-OS, DIO3-AS1, C14orf134, NCRNA00041" lncRNA Homo sapiens 26937624 Cytoplasm NCM356 qRT-PCR "The NCode human noncoding RNA (ncRNA) Microarray V2 (Invitrogen) was used to assess the expression of 17,112 lncRNAs and 22,074 mRNA in individual RNA samples from each patient. The microarray raw data and normalized data have been deposited in NCBI Gene Expression Omnibus (GEO) database under accession number GSE72221. Most lncRNAs demonstrate predominant nuclear expression, whereas DIOA3AS and BC062296 demonstrated higher abundance in cytoplasm." RLID00041633 643236 TMEM72 http://www.ncbi.nlm.nih.gov/gene/?term=643236 "C10orf127, KSP37" mRNA Homo sapiens 26937624 Nucleus NCM356 qRT-PCR "The NCode human noncoding RNA (ncRNA) Microarray V2 (Invitrogen) was used to assess the expression of 17,112 lncRNAs and 22,074 mRNA in individual RNA samples from each patient. The microarray raw data and normalized data have been deposited in NCBI Gene Expression Omnibus (GEO) database under accession number GSE72221. We found that most of the lncRNAs are localized to the nucleus." RLID00041634 AK024366 AK024366 https://www.ncbi.nlm.nih.gov/nuccore/AK024366 mRNA Homo sapiens 26937624 Nucleus NCM356 qRT-PCR "We identified 329 lncRNAs with increased and 126 lncRNAs with decreased expression in active UC tissues compared with normal control tissues, including the most significantly upregulated (BC012900, AK001903, and AK023330) and downregulated (BC029135, CDKN2B-AS1, and BC062296) transcripts. The microarray raw data and normalized data have been deposited in NCBI Gene Expression Omnibus (GEO) database under accession number GSE72221. We found that most of the lncRNAs are localized to the nucleus." RLID00041635 BC046210 BC046210 https://www.ncbi.nlm.nih.gov/nuccore/BC046210 mRNA Homo sapiens 26937624 Nucleus NCM356 qRT-PCR "The NCode human noncoding RNA (ncRNA) Microarray V2 (Invitrogen) was used to assess the expression of 17,112 lncRNAs and 22,074 mRNA in individual RNA samples from each patient. The microarray raw data and normalized data have been deposited in NCBI Gene Expression Omnibus (GEO) database under accession number GSE72221. We found that most of the lncRNAs are localized to the nucleus." RLID00041636 10178800 CR18854 http://www.ncbi.nlm.nih.gov/gene/?term=10178800 CG13122; CG18854; Dmel\CR18854 lncRNA Drosophila melanogaster 26944682 Cytoplasm embryo RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041637 10178829 CR32218 http://www.ncbi.nlm.nih.gov/gene/?term=10178829 CG8037; Dmel\CR32218 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 4-9 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041638 10178834 CR42646 http://www.ncbi.nlm.nih.gov/gene/?term=10178834 CR41445; Dmel\CR42646 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 6-9 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041639 10178834 CR42646 http://www.ncbi.nlm.nih.gov/gene/?term=10178834 CR41445; Dmel\CR42646 lncRNA Drosophila melanogaster 26944682 Nucleus Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041640 10178917 CR31044 http://www.ncbi.nlm.nih.gov/gene/?term=10178917 BcDNA:SD09455; CG31044; Dmel\CR31044; pri-mir-279_mir-996 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 1-7 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041641 10178917 CR31044 http://www.ncbi.nlm.nih.gov/gene/?term=10178917 BcDNA:SD09455; CG31044; Dmel\CR31044; pri-mir-279_mir-996 lncRNA Drosophila melanogaster 26944682 Nucleus Embryo stage 1-7 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041642 10178937 pncr014:3L http://www.ncbi.nlm.nih.gov/gene/?term=10178937 BEST:LD13184; CR33944; CR42871; Dmel\CR42871 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 1-5 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041643 10178937 pncr014:3L http://www.ncbi.nlm.nih.gov/gene/?term=10178937 BEST:LD13184; CR33944; CR42871; Dmel\CR42871 lncRNA Drosophila melanogaster 26944682 Nucleus Embryo stage 6-7 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041644 10178944 CR32690 http://www.ncbi.nlm.nih.gov/gene/?term=10178944 BEST:LP10814; CG32690; Dmel\CR32690 lncRNA Drosophila melanogaster 26944682 Nucleus Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041645 10178956 pncr014:3L http://www.ncbi.nlm.nih.gov/gene/?term=10178956 BEST:LD13184; CR33944; CR42871; Dmel\CR42871 lncRNA Drosophila melanogaster 26944682 Nucleus Embryo stage 8-9 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041646 10178964 CR42862 http://www.ncbi.nlm.nih.gov/gene/?term=10178964 anon-EST:fe1H7; BcDNA:GH06422; CG13878; CG16971; CG32477; CR32477; Dmel\CR42862 lncRNA Drosophila melanogaster 26944682 Nucleus Embryo stage 4-9 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041647 12797878 CR43464 http://www.ncbi.nlm.nih.gov/gene/?term=12797878 Dmel\CR43464 lncRNA Drosophila melanogaster 26944682 Nucleus Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041648 12797878 CR43464 http://www.ncbi.nlm.nih.gov/gene/?term=12797878 Dmel\CR43464 lncRNA Drosophila melanogaster 26944682 Nucleus larva intestine RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041649 12797885 CR31386 http://www.ncbi.nlm.nih.gov/gene/?term=12797885 BcDNA:RE39877; CG31386; Dmel\CR31386 lncRNA Drosophila melanogaster 26944682 Cytoplasm embryo RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041650 12797909 CR43159 http://www.ncbi.nlm.nih.gov/gene/?term=12797909 Dmel\CR43159 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 6-7 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041651 12797932 CR32194 http://www.ncbi.nlm.nih.gov/gene/?term=12797932 BcDNA:RE06388; CG32194; Dmel\CR32194 lncRNA Drosophila melanogaster 26944682 Cytoplasm embryo RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041652 12797935 CR32027 http://www.ncbi.nlm.nih.gov/gene/?term=12797935 BcDNA:RE02231; CG32027; Dmel\CR32027 lncRNA Drosophila melanogaster 26944682 Cytoplasm embryo RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041653 12798215 CR43463 http://www.ncbi.nlm.nih.gov/gene/?term=12798215 anon-35Aa; Dmel\CR43463 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 6-9 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041654 12798248 CR31781 http://www.ncbi.nlm.nih.gov/gene/?term=12798248 BcDNA:GH27691; BcDNA:LP04536; CG15131; CG15132; CG31781; Dmel\CR31781 lncRNA Drosophila melanogaster 26944682 Cytoplasm embryo RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041655 12798274 CR43476 http://www.ncbi.nlm.nih.gov/gene/?term=12798274 Dmel\CR43476 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 6-9 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041656 12798274 CR43476 http://www.ncbi.nlm.nih.gov/gene/?term=12798274 Dmel\CR43476 lncRNA Drosophila melanogaster 26944682 Nucleus Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041657 12798336 CR30121 http://www.ncbi.nlm.nih.gov/gene/?term=12798336 BcDNA:GH12850; CG30121; Dmel\CR30121 lncRNA Drosophila melanogaster 26944682 Nucleus Embryo stage 1-3 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041658 12798336 CR30121 http://www.ncbi.nlm.nih.gov/gene/?term=12798336 BcDNA:GH12850; CG30121; Dmel\CR30121 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 4-5 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041659 12798336 CR30121 http://www.ncbi.nlm.nih.gov/gene/?term=12798336 BcDNA:GH12850; CG30121; Dmel\CR30121 lncRNA Drosophila melanogaster 26944682 Nucleus Embryo stage 6-7 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041660 12798359 CR32252 http://www.ncbi.nlm.nih.gov/gene/?term=12798359 BcDNA:AT23419; CG32252; Dmel\CR32252 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 6-9 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041661 12798366 CR43470 http://www.ncbi.nlm.nih.gov/gene/?term=12798366 Dmel\CR43470 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 1-7 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041662 12798470 CR43426 http://www.ncbi.nlm.nih.gov/gene/?term=12798470 Dmel\CR43426 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 8-9 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041663 12798483 CR43429 http://www.ncbi.nlm.nih.gov/gene/?term=12798483 Dmel\CR43429 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 6-7 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041664 12798562 CR31647 http://www.ncbi.nlm.nih.gov/gene/?term=12798562 BcDNA:RE16275; CG31647; Dmel\CR31647 lncRNA Drosophila melanogaster 26944682 Cytoplasm embryo RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041665 12798562 CR31647 http://www.ncbi.nlm.nih.gov/gene/?term=12798562 BcDNA:RE16275; CG31647; Dmel\CR31647 lncRNA Drosophila melanogaster 26944682 Cytoplasm Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041666 12798562 CR31647 http://www.ncbi.nlm.nih.gov/gene/?term=12798562 BcDNA:RE16275; CG31647; Dmel\CR31647 lncRNA Drosophila melanogaster 26944682 Cytoplasm Larva muscle RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041667 14462359 CR44029 http://www.ncbi.nlm.nih.gov/gene/?term=14462359 Dmel\CR44029 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 1-7 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041668 14462440 CR42651 http://www.ncbi.nlm.nih.gov/gene/?term=14462440 CG42651; Dmel\CR42651; pri-mir-10 lncRNA Drosophila melanogaster 26944682 Nucleus Embryo stage 4-6 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041669 14462514 CR44052 http://www.ncbi.nlm.nih.gov/gene/?term=14462514 Dmel\CR44052 lncRNA Drosophila melanogaster 26944682 Nucleus Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041670 14462516 CR44097 http://www.ncbi.nlm.nih.gov/gene/?term=14462516 Dmel\CR44097 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 4-7 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041671 14462604 CR43964 http://www.ncbi.nlm.nih.gov/gene/?term=14462604 Dmel\CR43964 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 1-3 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041672 14462655 CR43649 http://www.ncbi.nlm.nih.gov/gene/?term=14462655 Dmel\CR43649 lncRNA Drosophila melanogaster 26944682 Cytoplasm Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041673 14462890 CR43872 http://www.ncbi.nlm.nih.gov/gene/?term=14462890 CG43872; Dmel\CR43872 lncRNA Drosophila melanogaster 26944682 Nucleus Embryo stage 1-3 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041674 14462890 CR43872 http://www.ncbi.nlm.nih.gov/gene/?term=14462890 CG43872; Dmel\CR43872 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 1-5 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041675 14462918 CR40053 http://www.ncbi.nlm.nih.gov/gene/?term=14462918 BcDNA:AT11374; CG40053; Dmel\CR40053 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 4-5 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041676 14462918 CR40053 http://www.ncbi.nlm.nih.gov/gene/?term=14462918 BcDNA:AT11374; CG40053; Dmel\CR40053 lncRNA Drosophila melanogaster 26944682 Nucleus Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041677 19835082 CR32111 http://www.ncbi.nlm.nih.gov/gene/?term=19835082 CG32111; Dmel\CR32111 lncRNA Drosophila melanogaster 26944682 Cytoplasm Larva ring glands RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041678 19835193 CR44898 http://www.ncbi.nlm.nih.gov/gene/?term=19835193 Dmel\CR44898 lncRNA Drosophila melanogaster 26944682 Cytoplasm Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041679 19835321 CR44872 http://www.ncbi.nlm.nih.gov/gene/?term=19835321 Dmel\CR44872 lncRNA Drosophila melanogaster 26944682 Nucleus Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041680 19835567 CR45018 http://www.ncbi.nlm.nih.gov/gene/?term=19835567 Dmel\CR45018 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 1-7 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041681 19835581 CR45030 http://www.ncbi.nlm.nih.gov/gene/?term=19835581 Dmel\CR45030 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 4-7 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041682 19835588 CR44690 http://www.ncbi.nlm.nih.gov/gene/?term=19835588 Dmel\CR44690 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 1-5 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041683 19835588 CR44690 http://www.ncbi.nlm.nih.gov/gene/?term=19835588 Dmel\CR44690 lncRNA Drosophila melanogaster 26944682 Cytoplasm Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041684 19835926 CR44945 http://www.ncbi.nlm.nih.gov/gene/?term=19835926 Dmel\CR44945; lincRNA.798 lncRNA Drosophila melanogaster 26944682 Cytoplasm Larva salivary gland RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041685 19835965 CR44931 http://www.ncbi.nlm.nih.gov/gene/?term=19835965 Dmel\CR44931; lincRNA.699 lncRNA Drosophila melanogaster 26944682 Nucleus Embryo stage 4-5 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041686 26067084 CR32582 http://www.ncbi.nlm.nih.gov/gene/?term=26067084 BcDNA:SD27303; CG32582; Dmel\CR32582; mdcds_55373 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 4-5 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041687 26067100 CR43174 http://www.ncbi.nlm.nih.gov/gene/?term=26067100 CG43173; CG43174; CR43173; Dmel\CR43174; mdcds_28406 lncRNA Drosophila melanogaster 26944682 Cytoplasm embryo RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041688 26067356 flam http://www.ncbi.nlm.nih.gov/gene/?term=26067356 COM; COM/flam; CR46037; Dmel\CR46037; lincRNA.1041 lncRNA Drosophila melanogaster 26944682 Nucleus Emrbyo stage 1-17 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041689 26067356 flam http://www.ncbi.nlm.nih.gov/gene/?term=26067356 COM; COM/flam; CR46037; Dmel\CR46037; lincRNA.1041 lncRNA Drosophila melanogaster 26944682 Nucleus Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041690 26067356 flam http://www.ncbi.nlm.nih.gov/gene/?term=26067356 COM; COM/flam; CR46037; Dmel\CR46037; lincRNA.1041 lncRNA Drosophila melanogaster 26944682 Nucleus Larva intestine RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041691 26067356 flam http://www.ncbi.nlm.nih.gov/gene/?term=26067356 COM; COM/flam; CR46037; Dmel\CR46037; lincRNA.1041 lncRNA Drosophila melanogaster 26944682 Cytoplasm Larva salivary gland RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041692 26067493 CR46179 http://www.ncbi.nlm.nih.gov/gene/?term=26067493 CG12717-related; Dmel\CR46179 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 1-3 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041693 3772088 pncr002:3R http://www.ncbi.nlm.nih.gov/gene/?term=3772088 BcDNA:LP03188; CR33938; Dmel\CR33938 lncRNA Drosophila melanogaster 26944682 Cytoplasm Larva salivary gland RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041694 3772102 CR32205 http://www.ncbi.nlm.nih.gov/gene/?term=3772102 BcDNA:RE73739; Dmel\CR32205; hp-CR32205 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 4-9 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041695 3772110 iab-4 http://www.ncbi.nlm.nih.gov/gene/?term=3772110 CR31271; Dmel\CR31271; I; iab; pri-mir-iab-4_mir-iab-4as lncRNA Drosophila melanogaster 26944682 Nucleus embryo RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041696 3772220 bxd http://www.ncbi.nlm.nih.gov/gene/?term=3772220 CR31273; CR31277; Dmel\CR31273 lncRNA Drosophila melanogaster 26944682 Nucleus embryo RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041697 3772292 pncr017:3R http://www.ncbi.nlm.nih.gov/gene/?term=3772292 BcDNA:SD10988; CR33945; Dmel\CR33945 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 6-7 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041698 3772297 CR32730 http://www.ncbi.nlm.nih.gov/gene/?term=3772297 BcDNA:RE54930; Dmel\CR32730; MRE32 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 4-9 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041699 3772376 roX1 http://www.ncbi.nlm.nih.gov/gene/?term=3772376 BcDNA:GH10432; chrX:3706836..3706970; CR32777; Dmel\CR32777; EG:EG0002.2; roX; rox-1; rox1; RoX1 lncRNA Drosophila melanogaster 26944682 Nucleus embryo RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041700 3772405 Cyp9f3Psi http://www.ncbi.nlm.nih.gov/gene/?term=3772405 9f3p; CG17875; CR17875; Cyp9f3; Cyp9f3p; Dmel\CR17875 lncRNA Drosophila melanogaster 26944682 Cytoplasm embryo RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041701 3772463 CR32385 http://www.ncbi.nlm.nih.gov/gene/?term=3772463 anon-WO0118547.23; BcDNA:LD18889; Dmel\CR32385; LD18889 lncRNA Drosophila melanogaster 26944682 Cytoplasm Larva salivary gland RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041702 3772538 CR33941 http://www.ncbi.nlm.nih.gov/gene/?term=3772538 BcDNA:GM01028; CG13303; CR33941; CT32596; Dmel\CG33941; MRE3; pncr013:4 mRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 1-3 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041703 3772538 CR33941 http://www.ncbi.nlm.nih.gov/gene/?term=3772538 BcDNA:GM01028; CG13303; CR33941; CT32596; Dmel\CG33941; MRE3; pncr013:4 mRNA Drosophila melanogaster 26944682 Nucleus Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041704 3772546 CR31969 http://www.ncbi.nlm.nih.gov/gene/?term=3772546 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 6-17 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041705 3885572 CR33963 http://www.ncbi.nlm.nih.gov/gene/?term=3885572 BcDNA:GH04518; Dmel\CR33963 lncRNA Drosophila melanogaster 26944682 Nucleus Embryo stage 4-5 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041706 3885572 CR33963 http://www.ncbi.nlm.nih.gov/gene/?term=3885572 BcDNA:GH04518; Dmel\CR33963 lncRNA Drosophila melanogaster 26944682 Cytoplasm Larva salivary gland RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041707 3885608 CR33987 http://www.ncbi.nlm.nih.gov/gene/?term=3885608 Dmel\CR33987 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 6-17 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041708 5740822 CR31032 http://www.ncbi.nlm.nih.gov/gene/?term=5740822 BcDNA:GH15189; CG31032; Dmel\CR31032 lncRNA Drosophila melanogaster 26944682 Nucleus Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041709 5740822 CR31032 http://www.ncbi.nlm.nih.gov/gene/?term=5740822 BcDNA:GH15189; CG31032; Dmel\CR31032 lncRNA Drosophila melanogaster 26944682 Cytoplasm Larva salivary gland RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041710 8673968 CR18166 http://www.ncbi.nlm.nih.gov/gene/?term=8673968 BEST:GH02584; CG13372; CG18166; Dmel\CR18166 lncRNA Drosophila melanogaster 26944682 Cytoplasm embryo RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041711 8674102 CR42549 http://www.ncbi.nlm.nih.gov/gene/?term=8674102 Dmel\CR42549 lncRNA Drosophila melanogaster 26944682 Nucleus Embryo stage 10-17 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041712 8674102 CR42549 http://www.ncbi.nlm.nih.gov/gene/?term=8674102 Dmel\CR42549 lncRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 6-7 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041713 8674102 CR42549 http://www.ncbi.nlm.nih.gov/gene/?term=8674102 Dmel\CR42549 lncRNA Drosophila melanogaster 26944682 Nucleus Larva fat body RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041714 8674102 CR42549 http://www.ncbi.nlm.nih.gov/gene/?term=8674102 Dmel\CR42549 lncRNA Drosophila melanogaster 26944682 Nucleus Larva intestine RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041715 U80893 U80893 https://www.ncbi.nlm.nih.gov/nuccore/U80893 mRNA Drosophila melanogaster 26944682 Cytoplasm Embryo stage 6-9 RNA-FISH "To see whether this prevalence is unique to early Drosophila embryos, we examined ~8000 transcripts over the full course of embryogenesis and ~800 transcripts in late third instar larval tissues. Data were collected from Fly-FISH database(http://fly-fish.ccbr.utoronto.ca). All were also seen to be redeployed in mesoderm and gut tissues during mid-embryogenesis, but localization at these stages was exclusively cytoplasmic." RLID00041716 55000 TUG1 http://www.ncbi.nlm.nih.gov/gene/?term=55000 "TI-227H, LINC00080, NCRNA00080" lncRNA Homo sapiens 26975529 Cytoplasm 22RV1 RNA-FISH "Among those sp-lncRNAs that were targeted by more than eight experimentally validated PTEN-regulating miRNAs, we chose two sp-lncRNAs lnc-2 (CTB-89H12.4, ENSG00000230551) and lnc-6 (Taurine Upregulated Gene 1 (TUG1), ENSG00000253352) that showed consistently the highest expression in two prostate cancer cell lines (DU145 and 22RV1) with wild-type PTEN for experimental validation. Indeed, lnc-2 and lnc-6 were predominantly localized in the cytoplasm in the DU145 and 22Rv1 cell lines, whereas lnc-7 was not. Data were collected from supplementary data 5." RLID00041717 55000 TUG1 http://www.ncbi.nlm.nih.gov/gene/?term=55000 "TI-227H, LINC00080, NCRNA00080" lncRNA Homo sapiens 26975529 Cytoplasm DU145 RNA-FISH "Among those sp-lncRNAs that were targeted by more than eight experimentally validated PTEN-regulating miRNAs, we chose two sp-lncRNAs lnc-2 (CTB-89H12.4, ENSG00000230551) and lnc-6 (Taurine Upregulated Gene 1 (TUG1), ENSG00000253352) that showed consistently the highest expression in two prostate cancer cell lines (DU145 and 22RV1) with wild-type PTEN for experimental validation. Indeed, lnc-2 and lnc-6 were predominantly localized in the cytoplasm in the DU145 and 22Rv1 cell lines, whereas lnc-7 was not. Data were collected from supplementary data 5." RLID00041718 ENSG00000230551 CTB-89H12.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230551 lncRNA Homo sapiens 26975529 Cytoplasm 22RV1 RNA-FISH "Among those sp-lncRNAs that were targeted by more than eight experimentally validated PTEN-regulating miRNAs, we chose two sp-lncRNAs lnc-2 (CTB-89H12.4, ENSG00000230551) and lnc-6 (Taurine Upregulated Gene 1 (TUG1), ENSG00000253352) that showed consistently the highest expression in two prostate cancer cell lines (DU145 and 22RV1) with wild-type PTEN for experimental validation. Indeed, lnc-2 and lnc-6 were predominantly localized in the cytoplasm in the DU145 and 22Rv1 cell lines, whereas lnc-7 was not. Data were collected from supplementary data 5." RLID00041719 ENSG00000230551 CTB-89H12.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230551 lncRNA Homo sapiens 26975529 Cytoplasm 22RV1 qRT-PCR "Among those sp-lncRNAs that were targeted by more than eight experimentally validated PTEN-regulating miRNAs, we chose two sp-lncRNAs lnc-2 (CTB-89H12.4, ENSG00000230551) and lnc-6 (Taurine Upregulated Gene 1 (TUG1), ENSG00000253352) that showed consistently the highest expression in two prostate cancer cell lines (DU145 and 22RV1) with wild-type PTEN for experimental validation. Indeed, lnc-2 and lnc-6 were predominantly localized in the cytoplasm in the DU145 and 22Rv1 cell lines, whereas lnc-7 was not. Data were collected from supplementary data 5." RLID00041720 ENSG00000230551 CTB-89H12.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230551 lncRNA Homo sapiens 26975529 Cytoplasm DU145 RNA-FISH "Among those sp-lncRNAs that were targeted by more than eight experimentally validated PTEN-regulating miRNAs, we chose two sp-lncRNAs lnc-2 (CTB-89H12.4, ENSG00000230551) and lnc-6 (Taurine Upregulated Gene 1 (TUG1), ENSG00000253352) that showed consistently the highest expression in two prostate cancer cell lines (DU145 and 22RV1) with wild-type PTEN for experimental validation. Indeed, lnc-2 and lnc-6 were predominantly localized in the cytoplasm in the DU145 and 22Rv1 cell lines, whereas lnc-7 was not. Data were collected from supplementary data 5." RLID00041721 ENSG00000230551 CTB-89H12.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230551 lncRNA Homo sapiens 26975529 Cytoplasm DU145 qRT-PCR "Among those sp-lncRNAs that were targeted by more than eight experimentally validated PTEN-regulating miRNAs, we chose two sp-lncRNAs lnc-2 (CTB-89H12.4, ENSG00000230551) and lnc-6 (Taurine Upregulated Gene 1 (TUG1), ENSG00000253352) that showed consistently the highest expression in two prostate cancer cell lines (DU145 and 22RV1) with wild-type PTEN for experimental validation. Indeed, lnc-2 and lnc-6 were predominantly localized in the cytoplasm in the DU145 and 22Rv1 cell lines, whereas lnc-7 was not. Data were collected from supplementary data 5." RLID00041722 ENSG00000267520 RP11-373L24.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267520 lncRNA Homo sapiens 26975529 Nucleus 22RV1 qRT-PCR "Here we identify a lncRNA-mediated sponge regulatory network that affects the expression of many protein-coding prostate cancer driver genes, by integrating analysis of sequence features and gene expression profiles of both lncRNAs and protein-coding genes in tumours. Data were collected from supplementary data 5. One of the validated PTEN sp-lncRNA lnc-6 (TUG1) was previously known to be involved in polycomb repressive complex 2-mediated transcriptional regulation and the three-dimensional organization of the transcription unit in the nucleus." RLID00041723 ENSG00000267520 RP11-373L24.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267520 lncRNA Homo sapiens 26975529 Cytoplasm 22RV1 qRT-PCR "Here we identify a lncRNA-mediated sponge regulatory network that affects the expression of many protein-coding prostate cancer driver genes, by integrating analysis of sequence features and gene expression profiles of both lncRNAs and protein-coding genes in tumours. Data were collected from supplementary data 5. Our findings not only suggest an important role of lncRNA-mediated sponge regulation in cancer, but also underscore the critical influence of cytoplasmic localization on the efficacy of a sponge lncRNA." RLID00041724 ENSG00000267520 RP11-373L24.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267520 lncRNA Homo sapiens 26975529 Nucleus 22RV1 RNA-FISH "Here we identify a lncRNA-mediated sponge regulatory network that affects the expression of many protein-coding prostate cancer driver genes, by integrating analysis of sequence features and gene expression profiles of both lncRNAs and protein-coding genes in tumours. Data were collected from supplementary data 5. One of the validated PTEN sp-lncRNA lnc-6 (TUG1) was previously known to be involved in polycomb repressive complex 2-mediated transcriptional regulation and the three-dimensional organization of the transcription unit in the nucleus." RLID00041725 ENSG00000267520 RP11-373L24.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267520 lncRNA Homo sapiens 26975529 Cytoplasm 22RV1 RNA-FISH "Here we identify a lncRNA-mediated sponge regulatory network that affects the expression of many protein-coding prostate cancer driver genes, by integrating analysis of sequence features and gene expression profiles of both lncRNAs and protein-coding genes in tumours. Data were collected from supplementary data 5. Our findings not only suggest an important role of lncRNA-mediated sponge regulation in cancer, but also underscore the critical influence of cytoplasmic localization on the efficacy of a sponge lncRNA." RLID00041726 ENSG00000267520 RP11-373L24.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267520 lncRNA Homo sapiens 26975529 Nucleus DU145 RNA-FISH "Here we identify a lncRNA-mediated sponge regulatory network that affects the expression of many protein-coding prostate cancer driver genes, by integrating analysis of sequence features and gene expression profiles of both lncRNAs and protein-coding genes in tumours. Data were collected from supplementary data 5. One of the validated PTEN sp-lncRNA lnc-6 (TUG1) was previously known to be involved in polycomb repressive complex 2-mediated transcriptional regulation and the three-dimensional organization of the transcription unit in the nucleus." RLID00041727 ENSG00000267520 RP11-373L24.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267520 lncRNA Homo sapiens 26975529 Cytoplasm DU145 RNA-FISH "Here we identify a lncRNA-mediated sponge regulatory network that affects the expression of many protein-coding prostate cancer driver genes, by integrating analysis of sequence features and gene expression profiles of both lncRNAs and protein-coding genes in tumours. Data were collected from supplementary data 5. Our findings not only suggest an important role of lncRNA-mediated sponge regulation in cancer, but also underscore the critical influence of cytoplasmic localization on the efficacy of a sponge lncRNA." RLID00041728 ENSG00000267520 RP11-373L24.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267520 lncRNA Homo sapiens 26975529 Nucleus DU145 qRT-PCR "Here we identify a lncRNA-mediated sponge regulatory network that affects the expression of many protein-coding prostate cancer driver genes, by integrating analysis of sequence features and gene expression profiles of both lncRNAs and protein-coding genes in tumours. Data were collected from supplementary data 5. One of the validated PTEN sp-lncRNA lnc-6 (TUG1) was previously known to be involved in polycomb repressive complex 2-mediated transcriptional regulation and the three-dimensional organization of the transcription unit in the nucleus." RLID00041729 ENSG00000267520 RP11-373L24.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000267520 lncRNA Homo sapiens 26975529 Cytoplasm DU145 qRT-PCR "Here we identify a lncRNA-mediated sponge regulatory network that affects the expression of many protein-coding prostate cancer driver genes, by integrating analysis of sequence features and gene expression profiles of both lncRNAs and protein-coding genes in tumours. Data were collected from supplementary data 5. Our findings not only suggest an important role of lncRNA-mediated sponge regulation in cancer, but also underscore the critical influence of cytoplasmic localization on the efficacy of a sponge lncRNA." RLID00041730 55611 OTUB1 http://www.ncbi.nlm.nih.gov/gene/?term=55611 "HSPC263, OTB1, OTU1" mRNA Homo sapiens 27019636 Nucleus Gastric cancer tissues qRT-PCR OTUB1-isoform 2 was predominantly localized in the cell nucleus. RLID00041731 100128260 WASIR1 http://www.ncbi.nlm.nih.gov/gene/?term=100128260 NCRNA00286B lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041732 100128292 DLG5-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100128292 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041733 100129387 GABPB1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100129387 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041734 100130476 LOC100130476 http://www.ncbi.nlm.nih.gov/gene/?term=100130476 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041735 100130476 LOC100130476 http://www.ncbi.nlm.nih.gov/gene/?term=100130476 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041736 100131067 CKMT2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100131067 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041737 100132077 LOC100132077 http://www.ncbi.nlm.nih.gov/gene/?term=100132077 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041738 100132774 KDM4A-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100132774 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041739 100132774 KDM4A-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100132774 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041740 100287765 LINC00630 http://www.ncbi.nlm.nih.gov/gene/?term=100287765 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041741 100289098 GS1-124K5.4 http://www.ncbi.nlm.nih.gov/gene/?term=100289098 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041742 100289509 KCNIP2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100289509 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041743 100302692 FTX http://www.ncbi.nlm.nih.gov/gene/?term=100302692 "LINC00182, MIR374AHG, NCRNA00182" lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041744 100306951 PITPNA-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100306951 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041745 100421432 HNRNPA1P44 http://www.ncbi.nlm.nih.gov/gene/?term=100421432 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041746 100505601 PARD3-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100505601 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041747 100505636 MALINC1 http://www.ncbi.nlm.nih.gov/gene/?term=100505636 "MA-linc1, LINC01024" lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041748 100505648 RAD51-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100505648 TODRA lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041749 100505771 MHENCR http://www.ncbi.nlm.nih.gov/gene/?term=100505771 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041750 100505854 APTR http://www.ncbi.nlm.nih.gov/gene/?term=100505854 RSBN1L-AS1 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041751 100505894 TMEM161B-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100505894 linc-POLR3G-8 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041752 100505894 TMEM161B-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100505894 linc-POLR3G-8 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041753 100506025 ISPD-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506025 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041754 100506054 RNASEH1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506054 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041755 100506080 HMGA1P4 http://www.ncbi.nlm.nih.gov/gene/?term=100506080 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041756 100506098 LOC100506098 http://www.ncbi.nlm.nih.gov/gene/?term=100506098 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041757 100506100 LOC100506100 http://www.ncbi.nlm.nih.gov/gene/?term=100506100 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041758 100506211 MIR210HG http://www.ncbi.nlm.nih.gov/gene/?term=100506211 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041759 100506233 RAB30-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506233 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041760 100506233 RAB30-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506233 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041761 100506305 LINC00958 http://www.ncbi.nlm.nih.gov/gene/?term=100506305 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041762 100506311 HOTAIRM1 http://www.ncbi.nlm.nih.gov/gene/?term=100506311 "HOXA-AS1, HOXA1-AS1, NCRNA00179" lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041763 100506314 LOC100506314 http://www.ncbi.nlm.nih.gov/gene/?term=100506314 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041764 100506314 LOC100506314 http://www.ncbi.nlm.nih.gov/gene/?term=100506314 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041765 100506365 OTUD6B-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506365 GS1-251I9.4 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041766 100506365 OTUD6B-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506365 GS1-251I9.4 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041767 100506392 SLC16A1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506392 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041768 100506469 TMEM147-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506469 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041769 100506649 PXN-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506649 EyeLinc4 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041770 100506649 PXN-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506649 EyeLinc4 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041771 100506660 DDX11-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100506660 CONCR lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041772 100506691 LOC100506691 http://www.ncbi.nlm.nih.gov/gene/?term=100506691 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041773 100506691 LOC100506691 http://www.ncbi.nlm.nih.gov/gene/?term=100506691 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041774 100507171 BOLA3-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100507171 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041775 100507194 LINC02525 http://www.ncbi.nlm.nih.gov/gene/?term=100507194 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041776 100507266 STX18-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100507266 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041777 100507316 MINCR http://www.ncbi.nlm.nih.gov/gene/?term=100507316 LINC01604 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041778 100507347 VIM-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100507347 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041779 100507475 IDH1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100507475 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041780 100507487 LOC100507487 http://www.ncbi.nlm.nih.gov/gene/?term=100507487 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041781 100507584 LINC01016 http://www.ncbi.nlm.nih.gov/gene/?term=100507584 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041782 100507602 TRIM52-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100507602 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041783 100508120 GMDS-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100508120 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041784 100508120 GMDS-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100508120 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041785 100509894 CPB2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100509894 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041786 100533182 SEC24B-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100533182 1/2-SBSRNA4 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041787 100652730 LINC00659 http://www.ncbi.nlm.nih.gov/gene/?term=100652730 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041788 100852408 EGFLAM-AS4 http://www.ncbi.nlm.nih.gov/gene/?term=100852408 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041789 100873938 GYG2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100873938 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041790 100873949 IPO9-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100873949 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041791 100873949 IPO9-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100873949 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041792 100874032 PRRT3-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874032 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041793 100874048 DGUOK-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874048 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041794 100874052 LINC00534 http://www.ncbi.nlm.nih.gov/gene/?term=100874052 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041795 100874069 STK24-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874069 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041796 100874110 GLYCTK-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874110 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041797 100874216 ZNF385D-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100874216 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041798 100874278 ERI3-IT1 http://www.ncbi.nlm.nih.gov/gene/?term=100874278 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041799 100874322 BACH1-IT2 http://www.ncbi.nlm.nih.gov/gene/?term=100874322 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041800 100874327 DSCR4-IT1 http://www.ncbi.nlm.nih.gov/gene/?term=100874327 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041801 100874364 HOXC-AS2 http://www.ncbi.nlm.nih.gov/gene/?term=100874364 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041802 100996301 FOXD3-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=100996301 pasFOXD3 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041803 101060264 FOXP4-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101060264 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041804 101060691 NUTM2B-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101060691 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041805 101926888 RALY-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101926888 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041806 101926926 RDH10-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101926926 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041807 101926934 LOC101926934 http://www.ncbi.nlm.nih.gov/gene/?term=101926934 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041808 101927125 ELFN1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101927125 MYCLo-2 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041809 101927221 UBR5-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101927221 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041810 101927289 LINC01237 http://www.ncbi.nlm.nih.gov/gene/?term=101927289 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041811 101927420 LOC101927420 http://www.ncbi.nlm.nih.gov/gene/?term=101927420 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041812 101927459 LINC01608 http://www.ncbi.nlm.nih.gov/gene/?term=101927459 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041813 101927621 LINC01534 http://www.ncbi.nlm.nih.gov/gene/?term=101927621 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041814 101927815 LOC101927815 http://www.ncbi.nlm.nih.gov/gene/?term=101927815 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041815 101927851 LOC101927851 http://www.ncbi.nlm.nih.gov/gene/?term=101927851 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041816 101927905 LINC02449 http://www.ncbi.nlm.nih.gov/gene/?term=101927905 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041817 101928000 LOC101928000 http://www.ncbi.nlm.nih.gov/gene/?term=101928000 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041818 101928000 LOC101928000 http://www.ncbi.nlm.nih.gov/gene/?term=101928000 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041819 101928017 UBXN10-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101928017 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041820 101928100 LOC101928100 http://www.ncbi.nlm.nih.gov/gene/?term=101928100 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041821 101928307 LOC101928307 http://www.ncbi.nlm.nih.gov/gene/?term=101928307 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041822 101928402 LOC101928402 http://www.ncbi.nlm.nih.gov/gene/?term=101928402 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041823 101928725 LOC101928725 http://www.ncbi.nlm.nih.gov/gene/?term=101928725 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041824 101928784 RORA-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101928784 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041825 101928834 LOC101928834 http://www.ncbi.nlm.nih.gov/gene/?term=101928834 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041826 101928857 CTD-3080P12.3 http://www.ncbi.nlm.nih.gov/gene/?term=101928857 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041827 101928973 LINC01732 http://www.ncbi.nlm.nih.gov/gene/?term=101928973 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041828 101929128 LOC101929128 http://www.ncbi.nlm.nih.gov/gene/?term=101929128 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041829 101929147 LOC101929147 http://www.ncbi.nlm.nih.gov/gene/?term=101929147 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041830 101929302 RFX3-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=101929302 CVAT7 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041831 101929378 LINC01876 http://www.ncbi.nlm.nih.gov/gene/?term=101929378 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041832 101929736 LINC01372 http://www.ncbi.nlm.nih.gov/gene/?term=101929736 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041833 101930114 LOC101930114 http://www.ncbi.nlm.nih.gov/gene/?term=101930114 mRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "29% (218/755) of protein-coding mRNAs are classified as heavy polysomal, consistent with their being actively translated and in accordance with previous studies. Data were collected from Supplemental Table S1. Potential protein-coding transcripts had a similar global ribosome-association profile to filtered lncRNA, suggesting that they are not translated efficiently, and underlining the stringency of our lncRNA filtering " RLID00041834 101930370 LOC101930370 http://www.ncbi.nlm.nih.gov/gene/?term=101930370 mRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "29% (218/755) of protein-coding mRNAs are classified as heavy polysomal, consistent with their being actively translated and in accordance with previous studies. Data were collected from Supplemental Table S1. As expected, protein-coding exons have highly elevated conservation. Free cytoplasmic, polysomal, and nuclear lncRNAs exhibit similar rates of nonneutral evolution." RLID00041835 102723517 LOC102723517 http://www.ncbi.nlm.nih.gov/gene/?term=102723517 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041836 102723828 LINC02506 http://www.ncbi.nlm.nih.gov/gene/?term=102723828 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041837 102723927 LINC01238 http://www.ncbi.nlm.nih.gov/gene/?term=102723927 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041838 102724450 LOC102724450 http://www.ncbi.nlm.nih.gov/gene/?term=102724450 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041839 102724954 LINC01032 http://www.ncbi.nlm.nih.gov/gene/?term=102724954 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041840 103352539 LINC01410 http://www.ncbi.nlm.nih.gov/gene/?term=103352539 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041841 103625681 LLPH-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=103625681 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041842 103695435 BBOX1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=103695435 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041843 103724390 LINC01287 http://www.ncbi.nlm.nih.gov/gene/?term=103724390 TCONS_l2_00027522 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041844 104326051 MAFA-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=104326051 TCONS_00014882 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041845 104355136 LINC01033 http://www.ncbi.nlm.nih.gov/gene/?term=104355136 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041846 104355148 CYP4A22-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=104355148 ncRNA-a3 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041847 104355152 LINC01090 http://www.ncbi.nlm.nih.gov/gene/?term=104355152 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041848 105372840 LINC01694 http://www.ncbi.nlm.nih.gov/gene/?term=105372840 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041849 105374524 LOC105374524 http://www.ncbi.nlm.nih.gov/gene/?term=105374524 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041850 105374524 LOC105374524 http://www.ncbi.nlm.nih.gov/gene/?term=105374524 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041851 105375475 LINC02476 http://www.ncbi.nlm.nih.gov/gene/?term=105375475 LVCAT5 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041852 105375606 MNX1-AS2 http://www.ncbi.nlm.nih.gov/gene/?term=105375606 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041853 105375666 LOC105375666 http://www.ncbi.nlm.nih.gov/gene/?term=105375666 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041854 105376736 LOC105376736 http://www.ncbi.nlm.nih.gov/gene/?term=105376736 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041855 105377348 LOC105377348 http://www.ncbi.nlm.nih.gov/gene/?term=105377348 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041856 105378687 LOC105378687 http://www.ncbi.nlm.nih.gov/gene/?term=105378687 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041857 105378763 LINC01748 http://www.ncbi.nlm.nih.gov/gene/?term=105378763 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041858 106480739 RHOA-IT1 http://www.ncbi.nlm.nih.gov/gene/?term=106480739 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041859 106480743 BRWD1-IT1 http://www.ncbi.nlm.nih.gov/gene/?term=106480743 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041860 107986453 LOC107986453 http://www.ncbi.nlm.nih.gov/gene/?term=107986453 mRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "29% (218/755) of protein-coding mRNAs are classified as heavy polysomal, consistent with their being actively translated and in accordance with previous studies. Data were collected from Supplemental Table S1. As expected, protein-coding exons have highly elevated conservation. Free cytoplasmic, polysomal, and nuclear lncRNAs exhibit similar rates of nonneutral evolution." RLID00041861 11257 TP53TG1 http://www.ncbi.nlm.nih.gov/gene/?term=11257 "P53TG1, TP53AP1, P53TG1-D, LINC00096, NCRNA00096" lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041862 150759 LINC00342 http://www.ncbi.nlm.nih.gov/gene/?term=150759 NCRNA00342 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041863 220906 WAC-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=220906 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041864 23642 SNHG1 http://www.ncbi.nlm.nih.gov/gene/?term=23642 "UHG, U22HG, lncRNA16, LINC00057, NCRNA00057" lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041865 23642 SNHG1 http://www.ncbi.nlm.nih.gov/gene/?term=23642 "UHG, U22HG, lncRNA16, LINC00057, NCRNA00057" lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041866 23642 SNHG1 http://www.ncbi.nlm.nih.gov/gene/?term=23642 "UHG, U22HG, lncRNA16, LINC00057, NCRNA00057" lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041867 253039 CUTALP http://www.ncbi.nlm.nih.gov/gene/?term=253039 PSMD5-AS1 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041868 257396 LOC257396 http://www.ncbi.nlm.nih.gov/gene/?term=257396 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041869 283596 SNHG10 http://www.ncbi.nlm.nih.gov/gene/?term=283596 "C14orf62, LINC00063, NCRNA00063" lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041870 283981 LINC00685 http://www.ncbi.nlm.nih.gov/gene/?term=283981 "CXYorf10, NCRNA00107, PPP2R3B-AS1" lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041871 284593 FAM41C http://www.ncbi.nlm.nih.gov/gene/?term=284593 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041872 284930 LOC284930 http://www.ncbi.nlm.nih.gov/gene/?term=284930 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041873 285084 LINC01305 http://www.ncbi.nlm.nih.gov/gene/?term=285084 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041874 340037 PRR7-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=340037 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041875 349408 TLR8-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=349408 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041876 378938 MALAT1 http://www.ncbi.nlm.nih.gov/gene/?term=378938 "HCN, LINC00047, NCRNA00047, NEAT2, PRO2853" lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041877 386597 RNF144A-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=386597 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041878 386627 SAP30L-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=386627 GALNT10-AS1 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041879 387066 SNHG5 http://www.ncbi.nlm.nih.gov/gene/?term=387066 "U50HG, C6orf160, LINC00044, bA33E24.2, NCRNA00044" lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041880 388796 SNHG17 http://www.ncbi.nlm.nih.gov/gene/?term=388796 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041881 388796 SNHG17 http://www.ncbi.nlm.nih.gov/gene/?term=388796 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041882 388796 SNHG17 http://www.ncbi.nlm.nih.gov/gene/?term=388796 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041883 400618 SOX9-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=400618 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041884 401106 LINC00884 http://www.ncbi.nlm.nih.gov/gene/?term=401106 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041885 401264 TRAM2-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=401264 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041886 401312 LOC401312 http://www.ncbi.nlm.nih.gov/gene/?term=401312 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041887 401588 ZNF674-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=401588 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041888 404663 CT49 http://www.ncbi.nlm.nih.gov/gene/?term=404663 "TAG, CT49" lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041889 414765 HCG25 http://www.ncbi.nlm.nih.gov/gene/?term=414765 dJ1033B10.16 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041890 439994 LINC00863 http://www.ncbi.nlm.nih.gov/gene/?term=439994 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041891 440584 SLC2A1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=440584 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041892 441307 HRAT92 http://www.ncbi.nlm.nih.gov/gene/?term=441307 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041893 4478 MSN http://www.ncbi.nlm.nih.gov/gene/?term=4478 "HEL70, IMD50" mRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "29% (218/755) of protein-coding mRNAs are classified as heavy polysomal, consistent with their being actively translated and in accordance with previous studies. Data were collected from Supplemental Table S1. Potential protein-coding transcripts had a similar global ribosome-association profile to filtered lncRNA, suggesting that they are not translated efficiently, and underlining the stringency of our lncRNA filtering " RLID00041894 4478 MSN http://www.ncbi.nlm.nih.gov/gene/?term=4478 "HEL70, IMD50" mRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "29% (218/755) of protein-coding mRNAs are classified as heavy polysomal, consistent with their being actively translated and in accordance with previous studies. Data were collected from Supplemental Table S1. As expected, protein-coding exons have highly elevated conservation. Free cytoplasmic, polysomal, and nuclear lncRNAs exhibit similar rates of nonneutral evolution." RLID00041895 493900 TMEM9B-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=493900 C11orf18 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041896 553103 MIR3936HG http://www.ncbi.nlm.nih.gov/gene/?term=553103 SLC22A5-AS1 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041897 553103 MIR3936HG http://www.ncbi.nlm.nih.gov/gene/?term=553103 SLC22A5-AS1 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041898 57291 DANCR http://www.ncbi.nlm.nih.gov/gene/?term=57291 "AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR" lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041899 57291 DANCR http://www.ncbi.nlm.nih.gov/gene/?term=57291 "AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR" lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041900 58160 NFE4 http://www.ncbi.nlm.nih.gov/gene/?term=58160 NF-E4 mRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "29% (218/755) of protein-coding mRNAs are classified as heavy polysomal, consistent with their being actively translated and in accordance with previous studies. Data were collected from Supplemental Table S1. Potential protein-coding transcripts had a similar global ribosome-association profile to filtered lncRNA, suggesting that they are not translated efficiently, and underlining the stringency of our lncRNA filtering " RLID00041901 60674 GAS5 http://www.ncbi.nlm.nih.gov/gene/?term=60674 "NCRNA00030, SNHG2" lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041902 60674 GAS5 http://www.ncbi.nlm.nih.gov/gene/?term=60674 "NCRNA00030, SNHG2" lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041903 619423 FAM85A http://www.ncbi.nlm.nih.gov/gene/?term=619423 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041904 641638 SNHG6 http://www.ncbi.nlm.nih.gov/gene/?term=641638 "U87HG, HBII-276HG, NCRNA00058" lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041905 641638 SNHG6 http://www.ncbi.nlm.nih.gov/gene/?term=641638 "U87HG, HBII-276HG, NCRNA00058" lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041906 643401 LINC01021 http://www.ncbi.nlm.nih.gov/gene/?term=643401 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041907 643837 LINC01128 http://www.ncbi.nlm.nih.gov/gene/?term=643837 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041908 643837 LINC01128 http://www.ncbi.nlm.nih.gov/gene/?term=643837 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041909 677822 SNORA40 http://www.ncbi.nlm.nih.gov/gene/?term=677822 "ACA40, SNORA40A" lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041910 692148 SCARNA10 http://www.ncbi.nlm.nih.gov/gene/?term=692148 U85 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041911 728769 SCAMP1-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=728769 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041912 729082 OIP5-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=729082 "cyrano, linc-OIP5" lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041913 729178 STXBP5-AS1 http://www.ncbi.nlm.nih.gov/gene/?term=729178 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041914 735301 SNHG9 http://www.ncbi.nlm.nih.gov/gene/?term=735301 NCRNA00062 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041915 7503 XIST http://www.ncbi.nlm.nih.gov/gene/?term=7503 "DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66" lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041916 7503 XIST http://www.ncbi.nlm.nih.gov/gene/?term=7503 "DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66" lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041917 ENSG00000115934 RP11-153K16.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000115934 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041918 ENSG00000189229 AC069277.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000189229 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041919 ENSG00000196295 AC005154.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000196295 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041920 ENSG00000205662 RP11-706O15.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000205662 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041921 ENSG00000213863 XX-C2158C12.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000213863 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041922 ENSG00000216775 RP1-152L7.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000216775 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041923 ENSG00000223379 RP11-374M1.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000223379 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041924 ENSG00000223473 GS1-124K5.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000223473 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041925 ENSG00000223473 GS1-124K5.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000223473 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041926 ENSG00000223812 RP11-197K6.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000223812 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041927 ENSG00000223960 AC009948.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000223960 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041928 ENSG00000224034 RP11-445P17.8 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224034 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041929 ENSG00000224066 RP4-622L5.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224066 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041930 ENSG00000224303 RP11-327I22.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224303 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041931 ENSG00000224505 AC002117.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224505 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041932 ENSG00000224536 RP11-134G8.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224536 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041933 ENSG00000224616 RP11-305E17.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224616 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041934 ENSG00000224635 RP4-564F22.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224635 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041935 ENSG00000224698 RP11-131J3.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224698 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041936 ENSG00000224699 LAMTOR5-AS1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224699 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041937 ENSG00000224790 AP000704.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224790 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041938 ENSG00000224903 AC005534.8 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224903 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041939 ENSG00000224934 RP11-441O15.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224934 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041940 ENSG00000224950 RP5-1086K13.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224950 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041941 ENSG00000224959 AC017002.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000224959 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041942 ENSG00000225135 RP11-361F15.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225135 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041943 ENSG00000225173 XXbac-BPG308K3.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225173 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041944 ENSG00000225205 AC093818.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225205 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041945 ENSG00000225265 RP11-378J18.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225265 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041946 ENSG00000225300 RP11-439E19.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225300 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041947 ENSG00000225335 XXbac-B476C20.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225335 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041948 ENSG00000225411 RP11-764K9.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225411 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041949 ENSG00000225450 RP3-508I15.14 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225450 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041950 ENSG00000225490 RP4-610C12.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225490 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041951 ENSG00000225548 AC098973.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225548 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041952 ENSG00000225793 RP1-234P15.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225793 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041953 ENSG00000225889 AC074289.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225889 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041954 ENSG00000225981 AC102953.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000225981 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041955 ENSG00000226043 AP000705.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000226043 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041956 ENSG00000226308 RP4-813D12.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000226308 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041957 ENSG00000226310 RP3-323P24.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000226310 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041958 ENSG00000226328 CTA-217C2.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000226328 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041959 ENSG00000226465 RP13-401N8.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000226465 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041960 ENSG00000226609 RP11-276E15.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000226609 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041961 ENSG00000226969 RP11-547D24.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000226969 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041962 ENSG00000227070 RP11-191G24.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000227070 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041963 ENSG00000227332 RP11-38M15.11 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000227332 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041964 ENSG00000227598 RP1-167A14.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000227598 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041965 ENSG00000227602 RP3-445N2.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000227602 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041966 ENSG00000227748 RP11-497D6.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000227748 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041967 ENSG00000227932 RP13-16H11.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000227932 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041968 ENSG00000228043 AC097721.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228043 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041969 ENSG00000228065 RP11-222A11.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228065 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041970 ENSG00000228100 AC016912.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228100 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041971 ENSG00000228160 RP13-57D9.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228160 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041972 ENSG00000228235 AP001476.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228235 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041973 ENSG00000228327 RP11-206L10.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228327 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041974 ENSG00000228384 AC007040.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228384 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041975 ENSG00000228541 AC093159.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228541 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041976 ENSG00000228649 AC005682.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228649 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041977 ENSG00000228742 RP5-884M6.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228742 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041978 ENSG00000228989 AC133528.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000228989 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041979 ENSG00000229043 AC091729.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000229043 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041980 ENSG00000229127 AC007038.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000229127 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041981 ENSG00000229299 RP4-583P15.10 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000229299 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041982 ENSG00000229591 RP5-981O7.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000229591 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041983 ENSG00000229801 RP11-353N4.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000229801 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041984 ENSG00000229832 RP11-384C4.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000229832 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041985 ENSG00000229953 RP11-284F21.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000229953 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041986 ENSG00000230074 RP11-195F19.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230074 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041987 ENSG00000230113 AC091177.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230113 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041988 ENSG00000230345 RP13-455A7.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230345 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041989 ENSG00000230648 RP3-406P24.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230648 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041990 ENSG00000230747 AC021188.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230747 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041991 ENSG00000230751 AC007036.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230751 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041992 ENSG00000230880 RP11-417J8.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230880 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041993 ENSG00000230918 AC008063.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000230918 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00041994 ENSG00000231025 RP11-175O19.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000231025 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00041995 ENSG00000231125 AF129075.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000231125 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041996 ENSG00000231481 RP11-292F9.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000231481 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041997 ENSG00000231485 RP4-535B20.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000231485 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041998 ENSG00000231612 RP11-522M21.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000231612 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00041999 ENSG00000231709 RP5-857K21.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000231709 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042000 ENSG00000231808 RP11-143M1.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000231808 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042001 ENSG00000231856 RP11-327P2.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000231856 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042002 ENSG00000231937 RP11-329E24.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000231937 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042003 ENSG00000232006 AC005537.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000232006 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042004 ENSG00000232019 AC074183.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000232019 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042005 ENSG00000232053 AC009784.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000232053 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042006 ENSG00000232093 RP11-307C12.11 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000232093 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042007 ENSG00000232336 RP11-782C8.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000232336 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042008 ENSG00000232874 RP11-135A1.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000232874 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042009 ENSG00000233396 RP11-458D21.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000233396 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042010 ENSG00000233461 RP11-295G20.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000233461 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042011 ENSG00000233547 RP11-57H14.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000233547 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042012 ENSG00000233654 AC093388.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000233654 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042013 ENSG00000233766 AC098617.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000233766 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042014 ENSG00000233875 RP11-61L14.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000233875 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042015 ENSG00000234072 AC074117.10 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234072 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042016 ENSG00000234129 RP11-120D5.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234129 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042017 ENSG00000234142 RP11-276E17.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234142 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042018 ENSG00000234147 RP3-460G2.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234147 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042019 ENSG00000234183 AC004854.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234183 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042020 ENSG00000234225 RP4-704D21.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234225 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042021 ENSG00000234245 RP11-94I2.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234245 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042022 ENSG00000234426 RP11-459O1.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234426 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042023 ENSG00000234584 AC019186.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234584 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042024 ENSG00000234593 RP4-704D23.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234593 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042025 ENSG00000234869 RP3-439F8.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234869 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042026 ENSG00000234902 AC007879.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234902 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042027 ENSG00000234913 XXbac-B476C20.13 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234913 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042028 ENSG00000234936 AC010883.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234936 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042029 ENSG00000234978 RP11-423O2.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234978 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042030 ENSG00000234986 XX-C2158C12.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000234986 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042031 ENSG00000235151 AC114730.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000235151 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042032 ENSG00000235245 RP11-122K13.12 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000235245 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042033 ENSG00000235335 AC016723.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000235335 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042034 ENSG00000235335 AC016723.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000235335 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042035 ENSG00000235781 XXbac-BPG249D20.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000235781 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042036 ENSG00000236140 RP11-89F3.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236140 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042037 ENSG00000236213 AC006369.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236213 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042038 ENSG00000236263 RP11-263K19.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236263 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042039 ENSG00000236519 AL773604.8 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236519 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042040 ENSG00000236537 RP11-732M18.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236537 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042041 ENSG00000236723 RP5-1024G6.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000236723 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042042 ENSG00000237015 CTA-984G1.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237015 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042043 ENSG00000237181 AC147651.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237181 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042044 ENSG00000237253 RP11-666A1.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237253 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042045 ENSG00000237311 RP6-159A1.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237311 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042046 ENSG00000237343 RP11-763B22.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237343 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042047 ENSG00000237410 AP001092.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237410 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042048 ENSG00000237429 RP1-159A19.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237429 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042049 ENSG00000237436 RP11-312B8.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237436 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042050 ENSG00000237587 RP11-327I22.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237587 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042051 ENSG00000237643 RP11-462G2.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237643 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042052 ENSG00000237753 AC079922.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237753 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042053 ENSG00000237886 RP11-611D20.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237886 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042054 ENSG00000237950 RP11-7O11.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237950 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042055 ENSG00000237976 RP11-126K1.6 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237976 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042056 ENSG00000237978 RP11-385J1.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000237978 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042057 ENSG00000238178 RP11-431J24.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000238178 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042058 ENSG00000239213 RP11-85F14.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000239213 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042059 ENSG00000239415 AP001469.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000239415 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042060 ENSG00000239705 RP11-65N13.8 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000239705 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042061 ENSG00000240015 RP11-90P5.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000240015 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042062 ENSG00000240291 RP11-499P20.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000240291 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042063 ENSG00000240562 RP11-59J16.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000240562 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042064 ENSG00000241732 RP11-38P22.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000241732 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042065 ENSG00000241860 RP11-34P13.13 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000241860 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042066 ENSG00000242622 RP11-18H7.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000242622 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042067 ENSG00000244239 AC007009.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000244239 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042068 ENSG00000244625 CTA-211A9.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000244625 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042069 ENSG00000244952 RP11-1000B6.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000244952 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042070 ENSG00000245261 RP3-330M21.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000245261 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042071 ENSG00000246493 RP11-68L18.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000246493 lncRNA Homo sapiens 27090285 Cytoplasm K570 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042072 ENSG00000246792 RP11-68L18.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000246792 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042073 ENSG00000247137 RP11-727A23.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000247137 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042074 ENSG00000247137 RP11-727A23.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000247137 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042075 ENSG00000247728 RP11-932O9.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000247728 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042076 ENSG00000247765 RP11-32B5.7 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000247765 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042077 ENSG00000247810 RP11-103J17.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000247810 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042078 ENSG00000247934 RP11-967K21.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000247934 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042079 ENSG00000248667 CTD-2331D11.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000248667 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042080 ENSG00000248774 RP11-798M19.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000248774 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042081 ENSG00000248783 RP11-308B16.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000248783 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042082 ENSG00000248839 RP11-227H4.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000248839 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042083 ENSG00000249174 RP11-124N3.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000249174 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042084 ENSG00000249356 RP11-21I10.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000249356 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042085 ENSG00000249413 RP11-25H12.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000249413 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042086 ENSG00000249502 AC006160.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000249502 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042087 ENSG00000249639 CTB-138E5.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000249639 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042088 ENSG00000249650 RP11-310P5.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000249650 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042089 ENSG00000250061 RP11-541P9.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250061 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042090 ENSG00000250081 CTD-2116N20.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250081 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042091 ENSG00000250102 RP11-314N14.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250102 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042092 ENSG00000250159 RP11-381K20.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250159 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042093 ENSG00000250159 RP11-381K20.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250159 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042094 ENSG00000250222 CTC-338M12.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250222 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042095 ENSG00000250410 RP11-714G18.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250410 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042096 ENSG00000250453 CTD-2134P3.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250453 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042097 ENSG00000250501 RP11-98O2.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250501 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042098 ENSG00000250604 RP11-597D13.8 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250604 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042099 ENSG00000250764 CTD-2152M20.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250764 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042100 ENSG00000250842 CTC-806A22.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250842 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042101 ENSG00000250874 CTC-480C2.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250874 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042102 ENSG00000250950 RP11-33B1.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000250950 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042103 ENSG00000251061 RP11-789C1.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000251061 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042104 ENSG00000251141 RP11-53O19.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000251141 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042105 ENSG00000251199 RP11-400D2.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000251199 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042106 ENSG00000251259 AC004069.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000251259 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042107 ENSG00000251387 CTB-35F21.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000251387 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042108 ENSG00000251487 RP11-124N3.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000251487 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042109 ENSG00000251637 RP11-119D9.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000251637 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042110 ENSG00000251661 RP11-326C3.11 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000251661 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042111 ENSG00000251676 RP11-614F17.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000251676 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042112 ENSG00000253154 CTA-392E5.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253154 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042113 ENSG00000253194 RP11-351A11.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253194 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042114 ENSG00000253235 RP11-434I12.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253235 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042115 ENSG00000253347 CTD-2026D20.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253347 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042116 ENSG00000253376 RP11-44D19.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253376 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042117 ENSG00000253476 RP11-395I14.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253476 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042118 ENSG00000253636 RP11-531A24.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253636 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042119 ENSG00000253753 AC145123.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253753 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042120 ENSG00000253853 GS1-57L11.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253853 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042121 ENSG00000253865 RP11-394O4.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253865 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042122 ENSG00000253931 RP11-909N17.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253931 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042123 ENSG00000253982 CTD-2336O2.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000253982 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042124 ENSG00000254002 RP11-213G6.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254002 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042125 ENSG00000254067 RP11-122L4.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254067 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042126 ENSG00000254165 RP11-503E24.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254165 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042127 ENSG00000254298 CTB-17P3.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254298 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042128 ENSG00000254458 RP11-867G23.13 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254458 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042129 ENSG00000254461 RP11-755F10.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254461 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042130 ENSG00000254477 AP000640.10 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254477 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042131 ENSG00000254518 RP11-347H15.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254518 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042132 ENSG00000254519 CTD-2210P24.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254519 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042133 ENSG00000254592 RP5-1173A5.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254592 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042134 ENSG00000254639 CTD-2589M5.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254639 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042135 ENSG00000254682 RP11-660L16.2 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254682 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042136 ENSG00000254694 RP11-50B3.4 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254694 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042137 ENSG00000254739 RP13-46H24.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254739 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042138 ENSG00000254760 CTD-2616J11.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254760 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042139 ENSG00000254812 RP11-661A12.12 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254812 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042140 ENSG00000254855 RP11-867G23.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000254855 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042141 ENSG00000255135 RP11-111M22.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255135 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042142 ENSG00000255176 AP002954.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255176 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042143 ENSG00000255224 CTD-3065J16.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255224 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042144 ENSG00000255229 RP11-304M2.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255229 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042145 ENSG00000255237 RP13-317D12.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255237 lncRNA Homo sapiens 27090285 Cytoplasm K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Fifty-four percent of expressed lncRNAs are detected in the cytoplasm." RLID00042146 ENSG00000255318 RP11-655M14.13 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255318 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042147 ENSG00000255471 RP11-736K20.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255471 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042148 ENSG00000255487 RP11-513D5.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255487 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042149 ENSG00000255655 RP11-256L11.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255655 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042150 ENSG00000255893 RP11-685N10.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255893 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042151 ENSG00000255966 RP5-940J5.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000255966 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042152 ENSG00000256101 RP11-90D4.3 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000256101 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042153 ENSG00000256258 RP11-495K9.9 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000256258 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042154 ENSG00000256433 RP1-102E24.8 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000256433 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042155 ENSG00000256473 RP11-437F6.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000256473 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042156 ENSG00000256742 RP13-941N14.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000256742 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042157 ENSG00000256922 RP11-749H20.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000256922 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042158 ENSG00000256940 RP11-783K16.5 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000256940 lncRNA Homo sapiens 27090285 Ribosome K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. Cytoplasmic and ribosomal localization has previously been reported for a number of lncRNA." RLID00042159 ENSG00000256967 RP11-273B20.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000256967 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042160 ENSG00000272328 RP4-594A5.1 http://grch37.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000272328 lncRNA Homo sapiens 27090285 Nucleus K562 cells Microarray "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from Supplemental Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042161 21823 Th http://www.ncbi.nlm.nih.gov/gene/?term=21823 mRNA Mus musculus 27095027 Axons Sympathetic Neurons qRT-PCR We show that TH mRNA is localized to distal axons. RLID00042162 90632 LINC00473 http://www.ncbi.nlm.nih.gov/gene/?term=90632 "C6orf176, bA142J11.1" lncRNA Homo sapiens 27140397 Nucleus FFPE human lung cancer specimens Fractionation assay "Moreover, exogenous LINC00473 showed similar nuclear localization when overexpressed in LKB1-WT H522 cells." RLID00042163 90632 LINC00473 http://www.ncbi.nlm.nih.gov/gene/?term=90632 "C6orf176, bA142J11.1" lncRNA Homo sapiens 27140397 Nucleus FFPE human lung cancer specimens RNA-FISH "Moreover, exogenous LINC00473 showed similar nuclear localization when overexpressed in LKB1-WT H522 cells." RLID00042164 394452 vegt http://www.ncbi.nlm.nih.gov/gene/?term=394452 "Apod, antipodean, brat, tVegT-a, vegt-b, xombi, vegt" mRNA Xenopus tropicalis 27140624 Nucleus Embryo RT-PCR "Therefore, nuclear staining with Anti-VegT in cleavage to blastula stages probably demonstrates the nuclear localization of VegT in embryos of these frogs." RLID00042165 723844 Mir338 http://www.ncbi.nlm.nih.gov/gene/?term=723844 "Mirn338, mir-338, mmu-mir-338" miRNA Mus musculus 27229124 Axons Superior Cervical Ganglion qRT-PCR "Using compartmentalized culture chambers, we also observed that labeled pre-miR-338 localized to distal axons and was also associated with axonal mitochondria." RLID00042166 102635290 Ttc39aos1 http://www.ncbi.nlm.nih.gov/gene/?term=102635290 "Gm12750, lincRNA-EPS" lncRNA Mus musculus 27315481 Nucleus Macrophages RT-qPCR The nuclear localization of lincRNA-EPS was also confirmed using single molecule RNA fluorescent in situ hybridization (FISH) in resting primary BMDMs. RLID00042167 1026 CDKN1A http://www.ncbi.nlm.nih.gov/gene/?term=1026 "CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1" mRNA Homo sapiens 27378782 Nucleus Dermal Fibroblasts qRT-PCR "Moreover, the structures formed by IRAlus are involved in the localization of hLincRNA-p21 in the nucleus, where hLincRNA-p21 colocalizes with paraspeckles." RLID00042168 14714 Gnrh1 http://www.ncbi.nlm.nih.gov/gene/?term=14714 "Gnrh, Gnrh2, LHRH, Lhrh1, Lnrh, hpg" mRNA Mus musculus 27389022 Nucleus cell lines RT-qPCR The localization of Gnrh1 mRNA in both the nucleus and cytoplasm is consistent with the robust Gnrh1 expression and GnRH synthesis in GT1-7 neurons. RLID00042169 14714 Gnrh1 http://www.ncbi.nlm.nih.gov/gene/?term=14714 "Gnrh, Gnrh2, LHRH, Lhrh1, Lnrh, hpg" mRNA Mus musculus 27389022 Cytoplasm cell lines RT-qPCR The localization of Gnrh1 mRNA in both the nucleus and cytoplasm is consistent with the robust Gnrh1 expression and GnRH synthesis in GT1-7 neurons. RLID00042170 27198 B3GNT2 http://www.ncbi.nlm.nih.gov/gene/?term=27198 "B3GNT, BGNT2, B3GNT1, BGnT-2,beta-1, 3-Gn-T1, 3-Gn-T2, B3GN-T2, B3GNT-2, BETA3GNT, beta3Gn-T1, beta3Gn-T2" mRNA Homo sapiens 27477284 Axons DRG neuron qPCR "Immunostaining for nucleolin protein concomitantly with FISH for importin ¦Â1 mRNA revealed extensive axonal colocalization, as compared to similar analyses for ¦Â-actin or GAP43 mRNAs." RLID00042171 400123 LINC00548 http://www.ncbi.nlm.nih.gov/gene/?term=400123 lncRNA Homo sapiens 27572135 Nucleus HeLa and HEK293 cells RNA-FISH "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from supplemental meterial's Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042172 400123 LINC00548 http://www.ncbi.nlm.nih.gov/gene/?term=400123 lncRNA Homo sapiens 27572135 Nucleus HeLa and HEK293 cells qRT-PCR "Here we make a global, absolute estimate of the cytoplasmic and ribosome-associated population of stringently filtered lncRNAs in a human cell line using polysome profiling coupled to spike-in normalized microarray analysis. Data were collected from supplemental meterial's Table S1. From the remaining filtered lncRNA transcripts, an additional 292 transcripts (3.2%, representing 255 or 3.7% genes) were detected in the nucleus based on ENCODE data, and henceforth defined as nuclear-specific." RLID00042173 646982 LINC00598 http://www.ncbi.nlm.nih.gov/gene/?term=646982 lncFOXO1 lncRNA Homo sapiens 27572135 Nucleus HeLa and HEK293 cells RNA-FISH "We observed that linc00598 was mainly located in the nuclear compartment, similarly to Xist, a well-known nuclear lncRNA." RLID00042174 646982 LINC00598 http://www.ncbi.nlm.nih.gov/gene/?term=646982 lncFOXO1 lncRNA Homo sapiens 27572135 Nucleus HeLa and HEK293 cells qRT-PCR "We observed that linc00598 was mainly located in the nuclear compartment, similarly to Xist, a well-known nuclear lncRNA." RLID00042175 12310 Calca http://www.ncbi.nlm.nih.gov/gene/?term=12310 "CA, CGRP-1, CGRP1, Calc, Calc1, Cgrp, Ct, Ctn" mRNA Mus musculus 27665741 Paraspeckles Embryonic Fibroblasts RT-qPCR "In WT-MEFs, Ctn RNA is localized to paraspeckles, as confirmed by co-staining of cells with Neat1." RLID00042176 19782 Rmrp http://www.ncbi.nlm.nih.gov/gene/?term=19782 "Rmrpr, 1110032O22Rik" lncRNA Mus musculus 27699653 Cytoplasm HeLa and HEK293 cells PCR "Our findings indicate that RBPs HuR and GRSF1 govern the cytoplasmic and mitochondrial localization of the lncRNA RMRP, which is encoded by nuclear DNA but has key functions in mitochondria." RLID00042177 19782 Rmrp http://www.ncbi.nlm.nih.gov/gene/?term=19782 "Rmrpr, 1110032O22Rik" lncRNA Mus musculus 27699653 Mitochondria HeLa and HEK293 cells PCR "Our findings indicate that RBPs HuR and GRSF1 govern the cytoplasmic and mitochondrial localization of the lncRNA RMRP, which is encoded by nuclear DNA but has key functions in mitochondria." RLID00042178 57425 U90926 http://www.ncbi.nlm.nih.gov/gene/?term=57425 lncRNA Mus musculus 27780975 Cytoplasm Adipose Tissue FISH FISH results showed that lnc-U90926 was mainly located in the cytoplasm. RLID00042179 68949 Zfas1 http://www.ncbi.nlm.nih.gov/gene/?term=68949 "Zfos1, 1500012F01Rik" mRNA Mus musculus 27871336 Cytoplasm Breast Cancer Cells RT-PCR "Since cellular location will dictate function of lncRNA, cellular fractionation was performed to identify the subcellular localisation of ZFAS1 in MDA-MB-468 and MDA-MB-231 breast cancer cells. As indicated for MDA-MB-468 cell extracts, ZFAS1 was found in both the cytoplasm and nucleus, indicating that ZFAS1 is not restricted to a specific cellular compartment." RLID00042180 68949 Zfas1 http://www.ncbi.nlm.nih.gov/gene/?term=68949 "Zfos1, 1500012F01Rik" mRNA Mus musculus 27871336 Nucleus Breast Cancer Cells RT-PCR "Since cellular location will dictate function of lncRNA, cellular fractionation was performed to identify the subcellular localisation of ZFAS1 in MDA-MB-468 and MDA-MB-231 breast cancer cells. As indicated for MDA-MB-468 cell extracts, ZFAS1 was found in both the cytoplasm and nucleus, indicating that ZFAS1 is not restricted to a specific cellular compartment." RLID00042181 38565 HDAC1 http://www.ncbi.nlm.nih.gov/gene/?term=38565 "Dmel_CG7471, CG7471, DHDAC1, DRpd3, DmHDAC1, Dmel\CG7471, E(var)3-64BC, HDAC, HDAC-1, Hdac, Hdac1, RPD3, Rpd3, Rpd3/HDAC, Su(var)3-26, Su(var)326, Su(var)328, dHDAC-1, dHDAC1, dRPD3, dRpd3, dmHDA401, drpd3, hdac1, l(3)04556, l(3)64Cc, rpd3, rpd[3]" mRNA Drosophila melanogaster 27907135 Nucleus Fat bodies RT-qPCR "The strong Rpd3 signals clearly merged with the Fibrillarin signals, indicating that Rpd3 mainly localizes in the nucleolus." RLID00042182 208715 Hmgcs1 http://www.ncbi.nlm.nih.gov/gene/?term=208715 B130032C06Rik mRNA Mus musculus 28155669 Peroxisome Livers qRT-PCR "The immunoelectron microscopy of rat liver from the same study has shown that the cytosolic fraction of HMG-CoA synthase 1 is detected in the area surrounding peroxisomes, which is consistent with our data on localization of Hmgcs1 mRNA in the vicinity of peroxisome." RLID00042183 15569 Elavl2 http://www.ncbi.nlm.nih.gov/gene/?term=15569 "Hub, mel-N1" mRNA Mus musculus 28300211 Axons Neuronal cell PCR "As our predictions suggest that Elavl2 mRNA is localized in axons of MN, we sought to characterize its protein and mRNA localization." RLID00042184 12737 Cldn1 http://www.ncbi.nlm.nih.gov/gene/?term=12737 AI596271 mRNA Mus musculus 28455726 Tight Junction Mammary Glands qRT-PCR "Here, we briefly review our current understanding of claudin structure and function followed by an examination of changes in claudin mRNA and protein expression and localization through mammary gland development. Claudin-1 is clearly localized to tight junctions in mammary ducts in non-pregnant non-lactating animals." RLID00042185 12739 Cldn3 http://www.ncbi.nlm.nih.gov/gene/?term=12739 "AI182374, Cpetr2, mRVP1" mRNA Mus musculus 28455726 Tight Junction Mammary Glands qRT-PCR "Here, we briefly review our current understanding of claudin structure and function followed by an examination of changes in claudin mRNA and protein expression and localization through mammary gland development. In the lactating mouse both claudin-3 and claudin-8 are localized at the tight junction where they may be important in forming the paracellular barrier." RLID00042186 1366 CLDN7 http://www.ncbi.nlm.nih.gov/gene/?term=1366 "CLDN-7, CEPTRL2, CPETRL2, Hs.84359, claudin-1" mRNA Homo sapiens 28455726 Cytoplasm Mammary Glands qRT-PCR "Here, we briefly review our current understanding of claudin structure and function followed by an examination of changes in claudin mRNA and protein expression and localization through mammary gland development. Claudin-7 remained largely in the soluble fraction after LPS treatment, in keeping with its usual location in cytoplasmic vesicles." RLID00042187 54420 Cldn8 http://www.ncbi.nlm.nih.gov/gene/?term=54420 AI648025 mRNA Mus musculus 28455726 Tight Junction Mammary Glands qRT-PCR "Here, we briefly review our current understanding of claudin structure and function followed by an examination of changes in claudin mRNA and protein expression and localization through mammary gland development. In the lactating mouse both claudin-3 and claudin-8 are localized at the tight junction where they may be important in forming the paracellular barrier." RLID00042188 53413 Exoc7 http://www.ncbi.nlm.nih.gov/gene/?term=53413 "Exo70, sec70" mRNA Mus musculus 28536622 Cytoplasm Vascular Smooth Muscle qRT-PCR "The expression of the Exo70 gene in A7r5 cells was detected by RT-PCR and immunofluorescent staining. The results showed that Exo70 was expressed in A7r5 cells. Additionally, Exo70 expression was mainly localized in the cytoplasm and a small amount in the nucleus." RLID00042189 53413 Exoc7 http://www.ncbi.nlm.nih.gov/gene/?term=53413 "Exo70, sec70" mRNA Mus musculus 28536622 Nucleus Vascular Smooth Muscle qRT-PCR "The expression of the Exo70 gene in A7r5 cells was detected by RT-PCR and immunofluorescent staining. The results showed that Exo70 was expressed in A7r5 cells. Additionally, Exo70 expression was mainly localized in the cytoplasm and a small amount in the nucleus." RLID00042190 724102 SNHG4 http://www.ncbi.nlm.nih.gov/gene/?term=724102 "U19H, NCRNA00059" lncRNA Homo sapiens 9630250 Nucleoplasm HeLa cells qRT-PCR "Because the U19H RNA possesses limited potential for protein coding and shows a predominant nucleoplasmic localization, we suggest that the sole function of the U19H gene is to express the U19 intronic snoRNA."